-- dump date 20140620_084541 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 512566000001 SEQ_END SEQ_END NC_011072.1 2078953 2078953 DR NC_011072.1; contig end 2078953..2078953 Streptococcus pneumoniae G54 YP_002036722.1 CDS dnaA NC_011072.1 197 1558 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 197..1558 Streptococcus pneumoniae G54 6479623 YP_002036723.1 CDS dnaN NC_011072.1 1717 2853 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1717..2853 Streptococcus pneumoniae G54 6480778 YP_002036724.1 CDS SPG_0003 NC_011072.1 2918 3112 D identified by match to protein family HMM PF06107; hypothetical protein 2918..3112 Streptococcus pneumoniae G54 6479471 YP_002036725.1 CDS SPG_0004 NC_011072.1 3196 4311 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 3196..4311 Streptococcus pneumoniae G54 6479709 YP_002036726.1 CDS pth NC_011072.1 4382 4951 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4382..4951 Streptococcus pneumoniae G54 6479159 YP_002036727.1 CDS mfd NC_011072.1 4952 8461 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580; transcription-repair coupling factor 4952..8461 Streptococcus pneumoniae G54 6479186 YP_002036728.1 CDS SPG_0007 NC_011072.1 8519 8785 D identified by match to protein family HMM PF01479; S4 domain 8519..8785 Streptococcus pneumoniae G54 6479927 YP_002036729.1 CDS SPG_0008 NC_011072.1 8778 9146 D identified by match to protein family HMM PF04977; septum formation initiator 8778..9146 Streptococcus pneumoniae G54 6479742 YP_002036730.1 CDS SPG_0009 NC_011072.1 9151 9273 D hypothetical protein 9151..9273 Streptococcus pneumoniae G54 6479659 YP_002036731.1 CDS SPG_0010 NC_011072.1 9266 10534 D hypothetical protein 9266..10534 Streptococcus pneumoniae G54 6480346 YP_002036732.1 CDS tilS NC_011072.1 10531 11808 D identified by match to protein family HMM PF01171; match to protein family HMM TIGR02432; match to protein family HMM TIGR02433; tRNA(Ile)-lysidine synthase 10531..11808 Streptococcus pneumoniae G54 6480232 YP_002036733.1 CDS hpt NC_011072.1 11812 12354 D identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; hypoxanthine-guanine phosphoribosyltransferase 11812..12354 Streptococcus pneumoniae G54 6480008 YP_002036734.1 CDS SPG_0013 NC_011072.1 12370 14328 D identified by match to protein family HMM PF00004; match to protein family HMM PF01434; match to protein family HMM PF06480; match to protein family HMM TIGR01241; cell division protein FtsH 12370..14328 Streptococcus pneumoniae G54 6480187 YP_002036735.1 CDS SPG_0014 NC_011072.1 14450 14929 D transcriptional regulator ComX1 14450..14929 Streptococcus pneumoniae G54 6480223 YP_002036736.1 CDS SPG_0021 NC_011072.1 20407 20724 R IS1167 transposase complement(20407..20724) Streptococcus pneumoniae G54 6480113 YP_002036737.1 CDS SPG_0022 NC_011072.1 20757 20900 R IS1167 transposase complement(20757..20900) Streptococcus pneumoniae G54 6480207 YP_002036738.1 CDS SPG_0023 NC_011072.1 20948 21154 R IS1167 transposase complement(20948..21154) Streptococcus pneumoniae G54 6479125 YP_002036739.1 CDS SPG_0024 NC_011072.1 21470 21706 D identified by glimmer; putative; hypothetical protein 21470..21706 Streptococcus pneumoniae G54 6479635 YP_002036740.1 CDS purA NC_011072.1 21895 23223 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 21895..23223 Streptococcus pneumoniae G54 6479952 YP_002036741.1 CDS SPG_0026 NC_011072.1 23424 23744 D contains potential frameshift; identified by match to protein family HMM PF00383; cytosine/adenosine deaminase 23424..23744 Streptococcus pneumoniae G54 6478825 YP_002036742.1 CDS SPG_0027 NC_011072.1 23710 23826 D contains potential frameshift; cytosine/adenosine deaminase 23710..23826 Streptococcus pneumoniae G54 6479762 YP_002036743.1 CDS dut NC_011072.1 24077 24520 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 24077..24520 Streptococcus pneumoniae G54 6479988 YP_002036744.1 CDS SPG_0029 NC_011072.1 24480 25037 D identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein 24480..25037 Streptococcus pneumoniae G54 6479002 YP_002036745.1 CDS radA NC_011072.1 25150 26412 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 25150..26412 Streptococcus pneumoniae G54 6479294 YP_002036746.1 CDS SPG_0031 NC_011072.1 26485 26982 D identified by match to protein family HMM PF00484; hypothetical protein 26485..26982 Streptococcus pneumoniae G54 6480370 YP_002036747.1 CDS SPG_0032 NC_011072.1 27007 27537 D contains potential frameshift; hypothetical protein 27007..27537 Streptococcus pneumoniae G54 6479579 YP_002036748.1 CDS SPG_0033 NC_011072.1 27530 27661 D contains potential frameshift; hypothetical protein 27530..27661 Streptococcus pneumoniae G54 6480066 YP_002036749.1 CDS prs1 NC_011072.1 27806 28774 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 27806..28774 Streptococcus pneumoniae G54 6480158 YP_002036750.1 CDS SPG_0035 NC_011072.1 29315 29548 R hypothetical protein complement(29315..29548) Streptococcus pneumoniae G54 6480480 YP_002036751.1 CDS SPG_0036 NC_011072.1 29541 29657 R identified by glimmer; putative; hypothetical protein complement(29541..29657) Streptococcus pneumoniae G54 6479882 YP_002036752.1 CDS SPG_0037 NC_011072.1 29872 30186 R hypothetical protein complement(29872..30186) Streptococcus pneumoniae G54 6478774 YP_002036753.1 CDS polA NC_011072.1 30478 33111 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 30478..33111 Streptococcus pneumoniae G54 6479502 YP_002036754.1 CDS SPG_0039 NC_011072.1 33196 33633 D identified by glimmer; putative; hypothetical protein 33196..33633 Streptococcus pneumoniae G54 6480801 YP_002036755.1 CDS SPG_0040 NC_011072.1 33816 34826 R identified by match to protein family HMM PF03601; hypothetical protein complement(33816..34826) Streptococcus pneumoniae G54 6480199 YP_002036756.1 CDS SPG_0041 NC_011072.1 34975 36144 D catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 34975..36144 Streptococcus pneumoniae G54 6478850 YP_002036757.1 CDS recO NC_011072.1 36141 36911 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 36141..36911 Streptococcus pneumoniae G54 6480494 YP_002036758.1 CDS SPG_0043 NC_011072.1 36908 37900 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 36908..37900 Streptococcus pneumoniae G54 6479529 YP_002036759.1 CDS SPG_0044 NC_011072.1 37906 38139 D acyl carrier protein 37906..38139 Streptococcus pneumoniae G54 6478663 YP_002036760.1 CDS SPG_0045 NC_011072.1 38182 38475 D transposase 38182..38475 Streptococcus pneumoniae G54 6479113 YP_002036761.1 CDS SPG_0046 NC_011072.1 38678 38908 D identified by match to protein family HMM TIGR01847; hypothetical protein 38678..38908 Streptococcus pneumoniae G54 6479931 YP_002036762.1 CDS SPG_0047 NC_011072.1 38911 39036 D identified by glimmer; putative; hypothetical protein 38911..39036 Streptococcus pneumoniae G54 6479323 YP_002036763.1 CDS comA NC_011072.1 39623 41776 D identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193; transport/processing ATP-binding protein ComA 39623..41776 Streptococcus pneumoniae G54 6479211 YP_002036764.1 CDS comB NC_011072.1 41789 43138 D identified by match to protein family HMM TIGR01000; competence factor transport protein ComB 41789..43138 Streptococcus pneumoniae G54 6479544 YP_002036765.1 CDS purC NC_011072.1 43308 44015 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 43308..44015 Streptococcus pneumoniae G54 6479608 YP_002036766.1 CDS purL NC_011072.1 44072 47797 D identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857; phosphoribosylformylglycinamide synthetase 44072..47797 Streptococcus pneumoniae G54 6479310 YP_002036767.1 CDS purF NC_011072.1 47890 49332 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 47890..49332 Streptococcus pneumoniae G54 6478668 YP_002036768.1 CDS purM NC_011072.1 49369 50391 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 49369..50391 Streptococcus pneumoniae G54 6480229 YP_002036769.1 CDS purN NC_011072.1 50388 50933 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 50388..50933 Streptococcus pneumoniae G54 6478742 YP_002036770.1 CDS SPG_0055 NC_011072.1 51017 51526 D identified by match to protein family HMM PF04892; hypothetical protein 51017..51526 Streptococcus pneumoniae G54 6479163 YP_002036771.1 CDS purH NC_011072.1 51551 53098 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 51551..53098 Streptococcus pneumoniae G54 6479017 YP_002036772.1 CDS purD NC_011072.1 53220 54482 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 53220..54482 Streptococcus pneumoniae G54 6480009 YP_002036773.1 CDS purE NC_011072.1 54885 55373 D identified by match to protein family HMM PF00731; match to protein family HMM TIGR01162; phosphoribosylaminoimidazole carboxylase catalytic subunit 54885..55373 Streptococcus pneumoniae G54 6479555 YP_002036774.1 CDS purK NC_011072.1 55360 56451 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 55360..56451 Streptococcus pneumoniae G54 6480634 YP_002036775.1 CDS SPG_0060 NC_011072.1 56461 56688 D identified by glimmer; putative; hypothetical protein 56461..56688 Streptococcus pneumoniae G54 6479567 YP_002036776.1 CDS purB NC_011072.1 56751 58049 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 56751..58049 Streptococcus pneumoniae G54 6479736 YP_002036777.1 CDS SPG_0062 NC_011072.1 58104 62042 R identified by match to protein family HMM PF00728; match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-N-acetylhexosaminidase complement(58104..62042) Streptococcus pneumoniae G54 6478652 YP_002036778.1 CDS SPG_0063 NC_011072.1 62357 63100 R identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator complement(62357..63100) Streptococcus pneumoniae G54 6479531 YP_002036779.1 CDS SPG_0064 NC_011072.1 63421 65208 D identified by match to protein family HMM PF01301; match to protein family HMM PF02449; beta-galactosidase 63421..65208 Streptococcus pneumoniae G54 6479805 YP_002036780.1 CDS SPG_0065 NC_011072.1 65205 65681 D identified by match to protein family HMM PF03830; PTS system transporter subunit IIB 65205..65681 Streptococcus pneumoniae G54 6478829 YP_002036781.1 CDS SPG_0066 NC_011072.1 65709 66614 D identified by match to protein family HMM PF03609; PTS system transporter subunit IIC 65709..66614 Streptococcus pneumoniae G54 6479467 YP_002036782.1 CDS SPG_0067 NC_011072.1 66601 67416 D identified by match to protein family HMM PF03613; PTS system transporter subunit IID 66601..67416 Streptococcus pneumoniae G54 6480744 YP_002036783.1 CDS SPG_0068 NC_011072.1 67423 67827 D identified by match to protein family HMM PF03610; PTS system transporter subunit IIA 67423..67827 Streptococcus pneumoniae G54 6480096 YP_002036784.1 CDS SPG_0069 NC_011072.1 68126 69292 D identified by match to protein family HMM PF01380; putative AgaS family sugar isomerase 68126..69292 Streptococcus pneumoniae G54 6480037 YP_002036785.1 CDS SPG_0070 NC_011072.1 69408 70445 D identified by match to protein family HMM PF01263; aldose-1-epimerase 69408..70445 Streptococcus pneumoniae G54 6480193 YP_002036786.1 CDS SPG_0071 NC_011072.1 70607 71119 D hypothetical protein 70607..71119 Streptococcus pneumoniae G54 6480168 YP_002036787.1 CDS cbpI NC_011072.1 71140 71775 D identified by match to protein family HMM PF01473; choline binding protein I 71140..71775 Streptococcus pneumoniae G54 6480667 YP_002036788.1 CDS SPG_0073 NC_011072.1 71778 71894 R identified by glimmer; putative; hypothetical protein complement(71778..71894) Streptococcus pneumoniae G54 6479116 YP_002036789.1 CDS zmpC NC_011072.1 72227 77797 D identified by match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM PF07581; zinc metalloprotease ZmpC 72227..77797 Streptococcus pneumoniae G54 6479482 YP_002036790.1 CDS SPG_0075 NC_011072.1 77900 78013 D hypothetical protein 77900..78013 Streptococcus pneumoniae G54 6479719 YP_002036791.1 CDS SPG_0076 NC_011072.1 78153 79007 D identified by match to protein family HMM PF00903; hypothetical protein 78153..79007 Streptococcus pneumoniae G54 6480099 YP_002036792.1 CDS SPG_0077 NC_011072.1 79113 79670 D acetyltransferase 79113..79670 Streptococcus pneumoniae G54 6480769 YP_002036793.1 CDS SPG_0078 NC_011072.1 79887 80651 D identified by match to protein family HMM PF01048; phosphorylase, Pnp/Udp family protein 79887..80651 Streptococcus pneumoniae G54 6478871 YP_002036794.1 CDS SPG_0079 NC_011072.1 81264 82643 D identified by match to protein family HMM PF02386; potassium uptake protein, Trk family protein 81264..82643 Streptococcus pneumoniae G54 6480024 YP_002036795.1 CDS SPG_0080 NC_011072.1 82657 83322 D identified by match to protein family HMM PF02254; Trk transporter NAD+ binding protein 82657..83322 Streptococcus pneumoniae G54 6479606 YP_002036796.1 CDS SPG_0081 NC_011072.1 83677 83850 D family 2 glycosyl transferase 83677..83850 Streptococcus pneumoniae G54 6479638 YP_002036797.1 CDS SPG_0082 NC_011072.1 83917 84327 D family 2 glycosyl transferase 83917..84327 Streptococcus pneumoniae G54 6480144 YP_002036798.1 CDS SPG_0083 NC_011072.1 84443 86104 D identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; cell wall surface anchor family protein 84443..86104 Streptococcus pneumoniae G54 6480367 YP_002036799.1 CDS SPG_0084 NC_011072.1 86271 86969 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator 86271..86969 Streptococcus pneumoniae G54 6480528 YP_002036800.1 CDS SPG_0085 NC_011072.1 86966 88018 D identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; histidine kinase 86966..88018 Streptococcus pneumoniae G54 6479985 YP_002036801.1 CDS rpsD NC_011072.1 88213 88824 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 88213..88824 Streptococcus pneumoniae G54 6479014 YP_002036802.1 CDS SPG_0087 NC_011072.1 89564 89824 D identified by glimmer; putative; hypothetical protein 89564..89824 Streptococcus pneumoniae G54 6479394 YP_002036803.1 CDS SPG_0088 NC_011072.1 89778 89999 D hypothetical protein 89778..89999 Streptococcus pneumoniae G54 6478751 YP_002036804.1 CDS SPG_0089 NC_011072.1 90318 91247 D identified by match to protein family HMM PF00528; ABC transporter permease 90318..91247 Streptococcus pneumoniae G54 6479019 YP_002036805.1 CDS SPG_0090 NC_011072.1 91261 92184 D identified by match to protein family HMM PF00528; ABC transporter permease 91261..92184 Streptococcus pneumoniae G54 6479641 YP_002036806.1 CDS SPG_0091 NC_011072.1 92394 93869 D identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein 92394..93869 Streptococcus pneumoniae G54 6480720 YP_002036807.1 CDS SPG_0092 NC_011072.1 94141 95127 D identified by glimmer; putative; hypothetical protein 94141..95127 Streptococcus pneumoniae G54 6479563 YP_002036808.1 CDS SPG_0093 NC_011072.1 95249 96109 D hypothetical protein 95249..96109 Streptococcus pneumoniae G54 6478807 YP_002036809.1 CDS SPG_0094 NC_011072.1 96181 97245 R identified by glimmer; putative; hypothetical protein complement(96181..97245) Streptococcus pneumoniae G54 6480519 YP_002036810.1 CDS SPG_0095 NC_011072.1 97308 98219 R hypothetical protein complement(97308..98219) Streptococcus pneumoniae G54 6479233 YP_002036811.1 CDS SPG_0096 NC_011072.1 98212 98805 R hypothetical protein complement(98212..98805) Streptococcus pneumoniae G54 6480632 YP_002036812.1 CDS SPG_0097 NC_011072.1 98792 99118 R identified by match to protein family HMM PF03551; PadR family transcriptional regulator complement(98792..99118) Streptococcus pneumoniae G54 6479573 YP_002036813.1 CDS SPG_0098 NC_011072.1 99257 100423 R identified by match to protein family HMM PF07690; transporter complement(99257..100423) Streptococcus pneumoniae G54 6478762 YP_002036814.1 CDS SPG_0099 NC_011072.1 100574 101638 D identified by match to protein family HMM PF00535; glycosyl transferase 100574..101638 Streptococcus pneumoniae G54 6479774 YP_002036815.1 CDS SPG_0100 NC_011072.1 101680 103530 D identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; capsular polysaccharide biosynthesis protein 101680..103530 Streptococcus pneumoniae G54 6480189 YP_002036816.1 CDS SPG_0101 NC_011072.1 103925 104557 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; haloacid dehalogenase-like hydrolase complement(103925..104557) Streptococcus pneumoniae G54 6479246 YP_002036817.1 CDS sdhA NC_011072.1 104579 105451 R identified by match to protein family HMM PF03313; match to protein family HMM TIGR00718; L-serine dehydratase subunit alpha complement(104579..105451) Streptococcus pneumoniae G54 6479316 YP_002036818.1 CDS sdhB NC_011072.1 105460 106131 R identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719; L-serine dehydratase subunit alpha complement(105460..106131) Streptococcus pneumoniae G54 6478802 YP_002036819.1 CDS SPG_0104 NC_011072.1 106372 106959 D identified by match to protein family HMM PF01476; LysM domain-containing protein 106372..106959 Streptococcus pneumoniae G54 6479851 YP_002036820.1 CDS SPG_0105 NC_011072.1 108094 110202 D identified by match to protein family HMM TIGR01654; ABC transporter membrane-spanning permease 108094..110202 Streptococcus pneumoniae G54 6480658 YP_002036821.1 CDS SPG_0106 NC_011072.1 110199 110840 D identified by match to protein family HMM PF00005; match to protein family HMM TIGR03608; ABC transporter ATP-binding protein 110199..110840 Streptococcus pneumoniae G54 6479272 YP_002036822.1 CDS SPG_0107 NC_011072.1 111047 111853 D identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein 111047..111853 Streptococcus pneumoniae G54 6479257 YP_002036823.1 CDS argG NC_011072.1 111870 112289 D identified by match to protein family HMM PF00764; argininosuccinate synthase 111870..112289 Streptococcus pneumoniae G54 6480574 YP_002036824.1 CDS SPG_0109 NC_011072.1 112577 112897 R hypothetical protein complement(112577..112897) Streptococcus pneumoniae G54 6478959 YP_002036825.1 CDS SPG_0110 NC_011072.1 113661 114014 D hypothetical protein 113661..114014 Streptococcus pneumoniae G54 6478778 YP_002036826.1 CDS SPG_0111 NC_011072.1 114011 114739 D identified by glimmer; putative; hypothetical protein 114011..114739 Streptococcus pneumoniae G54 6478875 YP_002036827.1 CDS SPG_0112 NC_011072.1 114893 115105 D hypothetical protein 114893..115105 Streptococcus pneumoniae G54 6479312 YP_002036828.1 CDS SPG_0113 NC_011072.1 115479 115604 D hypothetical protein 115479..115604 Streptococcus pneumoniae G54 6479900 YP_002036829.1 CDS SPG_0114 NC_011072.1 115987 117045 D hypothetical protein 115987..117045 Streptococcus pneumoniae G54 6478986 YP_002036830.1 CDS SPG_0115 NC_011072.1 117359 118333 D hypothetical protein 117359..118333 Streptococcus pneumoniae G54 6480203 YP_002036831.1 CDS SPG_0116 NC_011072.1 118807 119181 D hypothetical protein 118807..119181 Streptococcus pneumoniae G54 6479157 YP_002036832.1 CDS SPG_0117 NC_011072.1 119389 120291 D hypothetical protein 119389..120291 Streptococcus pneumoniae G54 6479523 YP_002036833.1 CDS SPG_0118 NC_011072.1 120347 120700 D hypothetical protein 120347..120700 Streptococcus pneumoniae G54 6479879 YP_002036834.1 CDS SPG_0119 NC_011072.1 120697 121425 D identified by glimmer; putative; hypothetical protein 120697..121425 Streptococcus pneumoniae G54 6478707 YP_002036835.1 CDS SPG_0120 NC_011072.1 122657 122809 D hypothetical protein 122657..122809 Streptococcus pneumoniae G54 6479490 YP_002036836.1 CDS pspA NC_011072.1 123363 125492 D identified by match to protein family HMM PF01473; surface protein A 123363..125492 Streptococcus pneumoniae G54 6480167 YP_002036837.1 CDS SPG_0122 NC_011072.1 125742 125870 D identified by glimmer; putative; hypothetical protein 125742..125870 Streptococcus pneumoniae G54 6479690 YP_002036838.1 CDS mnmA NC_011072.1 125893 127014 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 125893..127014 Streptococcus pneumoniae G54 6478673 YP_002036839.1 CDS SPG_0124 NC_011072.1 127155 127610 D identified by match to protein family HMM PF00293; NUDIX family hydrolase 127155..127610 Streptococcus pneumoniae G54 6479724 YP_002036840.1 CDS gidA NC_011072.1 127620 129533 D GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 127620..129533 Streptococcus pneumoniae G54 6480060 YP_002036841.1 CDS SPG_0126 NC_011072.1 129728 131407 R identified by match to protein family HMM PF00753; match to protein family HMM PF07521; match to protein family HMM TIGR00649; hypothetical protein complement(129728..131407) Streptococcus pneumoniae G54 6479853 YP_002036842.1 CDS SPG_0127 NC_011072.1 131409 131642 R identified by match to protein family HMM PF07288; hypothetical protein complement(131409..131642) Streptococcus pneumoniae G54 6480628 YP_002036843.1 CDS cibB NC_011072.1 132460 132612 R identified by match to protein family HMM TIGR01847; competence induced bacteriocin B complement(132460..132612) Streptococcus pneumoniae G54 6478957 YP_002036844.1 CDS cibA NC_011072.1 132614 132799 R Guiral PNAS 2005. 102(24):8710-8715; competence induced bacteriocin A CibA complement(132614..132799) Streptococcus pneumoniae G54 6480328 YP_002036845.1 CDS SPG_0130 NC_011072.1 132977 133660 D identified by match to protein family HMM PF00814; hypothetical protein 132977..133660 Streptococcus pneumoniae G54 6480504 YP_002036846.1 CDS SPG_0131 NC_011072.1 133657 134094 D identified by match to protein family HMM PF00583; match to protein family HMM TIGR01575; ribosomal-protein-alanine acetyltransferase 133657..134094 Streptococcus pneumoniae G54 6479126 YP_002036847.1 CDS SPG_0132 NC_011072.1 134084 135094 D in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 134084..135094 Streptococcus pneumoniae G54 6480130 YP_002036848.1 CDS SPG_0133 NC_011072.1 135134 135448 R IS1167 transposase complement(135134..135448) Streptococcus pneumoniae G54 6480627 YP_002036849.1 CDS SPG_0134 NC_011072.1 135439 136416 R identified by match to protein family HMM PF01610; IS1167 transposase complement(135439..136416) Streptococcus pneumoniae G54 6479694 YP_002036850.1 CDS SPG_0135 NC_011072.1 137637 138191 D contains potential frameshift; group 1 family glycosyl transferase 137637..138191 Streptococcus pneumoniae G54 6480693 YP_002036851.1 CDS SPG_0136 NC_011072.1 138169 138843 D contains potential frameshift; identified by match to protein family HMM PF00534; group 1 family glycosyl transferase 138169..138843 Streptococcus pneumoniae G54 6480285 YP_002036852.1 CDS SPG_0137 NC_011072.1 138836 139708 D identified by match to protein family HMM PF00535; group 2 family glycosyl transferase 138836..139708 Streptococcus pneumoniae G54 6480661 YP_002036853.1 CDS SPG_0138 NC_011072.1 139795 141411 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 139795..141411 Streptococcus pneumoniae G54 6480324 YP_002036854.1 CDS SPG_0139 NC_011072.1 142065 142847 D identified by match to protein family HMM PF01609; IS1380-Spn1 transposase 142065..142847 Streptococcus pneumoniae G54 6479261 YP_002036855.1 CDS SPG_0140 NC_011072.1 142992 143402 D IS1380-Spn1 transposase 142992..143402 Streptococcus pneumoniae G54 6480296 YP_002036856.1 CDS SPG_0141 NC_011072.1 143809 144558 D identified by match to protein family HMM PF02585; hypothetical protein 143809..144558 Streptococcus pneumoniae G54 6480724 YP_002036857.1 CDS SPG_0142 NC_011072.1 144571 145743 D identified by match to protein family HMM PF00984; match to protein family HMM PF03721; match to protein family HMM TIGR03026; UDP-glucose 6-dehydrogenase 144571..145743 Streptococcus pneumoniae G54 6479408 YP_002036858.1 CDS SPG_0143 NC_011072.1 146138 147001 D identified by match to protein family HMM TIGR01716; transcriptional regulator 146138..147001 Streptococcus pneumoniae G54 6479537 YP_002036859.1 CDS SPG_0144 NC_011072.1 147292 147525 D hypothetical protein 147292..147525 Streptococcus pneumoniae G54 6480549 YP_002036860.1 CDS SPG_0145 NC_011072.1 147547 148224 D identified by match to protein family HMM PF02517; CAAX amino terminal protease family 147547..148224 Streptococcus pneumoniae G54 6479980 YP_002036861.1 CDS SPG_0146 NC_011072.1 148236 148901 D identified by match to protein family HMM PF02517; CAAX amino terminal protease family 148236..148901 Streptococcus pneumoniae G54 6478700 YP_002036862.1 CDS SPG_0147 NC_011072.1 148973 150199 D hypothetical protein 148973..150199 Streptococcus pneumoniae G54 6480703 YP_002036863.1 CDS SPG_0148 NC_011072.1 150449 151117 D identified by match to protein family HMM PF03591; hypothetical protein 150449..151117 Streptococcus pneumoniae G54 6479761 YP_002036864.1 CDS SPG_0149 NC_011072.1 151107 151430 D identified by match to protein family HMM PF05437; hypothetical protein 151107..151430 Streptococcus pneumoniae G54 6479823 YP_002036865.1 CDS SPG_0150 NC_011072.1 151534 152364 D identified by match to protein family HMM PF00497; ABC transporter ATP-binding protein/ substrate-binding protein 151534..152364 Streptococcus pneumoniae G54 6480576 YP_002036866.1 CDS SPG_0151 NC_011072.1 152518 153372 D identified by match to protein family HMM PF03180; ABC transporter substrate binding protein 152518..153372 Streptococcus pneumoniae G54 6479227 YP_002036867.1 CDS SPG_0152 NC_011072.1 153472 154845 D identified by match to protein family HMM PF01546; match to protein family HMM PF07687; M20/M25/M40 family peptidase 153472..154845 Streptococcus pneumoniae G54 6479300 YP_002036868.1 CDS SPG_0153 NC_011072.1 154838 155899 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 154838..155899 Streptococcus pneumoniae G54 6480299 YP_002036869.1 CDS SPG_0154 NC_011072.1 155901 156593 D identified by match to protein family HMM PF00528; ABC transporter permease 155901..156593 Streptococcus pneumoniae G54 6479209 YP_002036870.1 CDS SPG_0155 NC_011072.1 156623 157192 R identified by match to protein family HMM TIGR02185; hypothetical protein complement(156623..157192) Streptococcus pneumoniae G54 6480405 YP_002036871.1 CDS SPG_0156 NC_011072.1 157327 157941 D identified by match to protein family HMM PF04854; hypothetical protein 157327..157941 Streptococcus pneumoniae G54 6480136 YP_002036872.1 CDS SPG_0157 NC_011072.1 157991 159589 D identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF06580; histidine kinase 157991..159589 Streptococcus pneumoniae G54 6479411 YP_002036873.1 CDS SPG_0158 NC_011072.1 159601 160887 D identified by match to protein family HMM PF00072; match to protein family HMM PF00165; response regulator 159601..160887 Streptococcus pneumoniae G54 6478817 YP_002036874.1 CDS SPG_0159 NC_011072.1 160939 161472 D hypothetical protein 160939..161472 Streptococcus pneumoniae G54 6480710 YP_002036875.1 CDS SPG_0160 NC_011072.1 161550 162020 D has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; flavoprotein NrdI 161550..162020 Streptococcus pneumoniae G54 6480812 YP_002036876.1 CDS SPG_0161 NC_011072.1 162313 163575 R hypothetical protein complement(162313..163575) Streptococcus pneumoniae G54 6480172 YP_002036877.1 CDS SPG_0162 NC_011072.1 163885 164343 R identified by glimmer; putative; hypothetical protein complement(163885..164343) Streptococcus pneumoniae G54 6480492 YP_002036878.1 CDS SPG_0163 NC_011072.1 164340 164780 R identified by match to protein family HMM PF04397; hypothetical protein complement(164340..164780) Streptococcus pneumoniae G54 6479275 YP_002036879.1 CDS SPG_0164 NC_011072.1 164896 165075 D hypothetical protein 164896..165075 Streptococcus pneumoniae G54 6479677 YP_002036880.1 CDS mutL NC_011072.1 165136 167085 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 165136..167085 Streptococcus pneumoniae G54 6479554 YP_002036881.1 CDS ribH NC_011072.1 167410 167877 R RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase complement(167410..167877) Streptococcus pneumoniae G54 6479334 YP_002036882.1 CDS SPG_0167 NC_011072.1 167878 169083 R identified by match to protein family HMM PF00925; match to protein family HMM PF00926; match to protein family HMM TIGR00505; match to protein family HMM TIGR00506; 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II complement(167878..169083) Streptococcus pneumoniae G54 6479887 YP_002036883.1 CDS SPG_0168 NC_011072.1 169103 169738 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(169103..169738) Streptococcus pneumoniae G54 6480051 YP_002036884.1 CDS SPG_0169 NC_011072.1 169723 170823 R identified by match to protein family HMM PF00383; match to protein family HMM PF01872; match to protein family HMM TIGR00227; match to protein family HMM TIGR00326; riboflavin biosynthesis protein complement(169723..170823) Streptococcus pneumoniae G54 6479495 YP_002036885.1 CDS ruvA NC_011072.1 171228 171821 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 171228..171821 Streptococcus pneumoniae G54 6479374 YP_002036886.1 CDS tag NC_011072.1 171831 172394 D identified by match to protein family HMM PF03352; DNA-3-methyladenine glycosylase I 171831..172394 Streptococcus pneumoniae G54 6479654 YP_002036887.1 CDS SPG_0172 NC_011072.1 172391 173068 D identified by match to protein family HMM PF02517; CAAX amino terminal protease family 172391..173068 Streptococcus pneumoniae G54 6480003 YP_002036888.1 CDS SPG_0173 NC_011072.1 173205 174236 R identified by match to protein family HMM PF02016; MccC family protein complement(173205..174236) Streptococcus pneumoniae G54 6478824 YP_002036889.1 CDS SPG_0174 NC_011072.1 174491 175174 R identified by match to protein family HMM PF06570; hypothetical protein complement(174491..175174) Streptococcus pneumoniae G54 6480205 YP_002036890.1 CDS SPG_0175 NC_011072.1 175186 176130 R identified by match to protein family HMM PF01544; CorA-like Mg2+ transporter protein complement(175186..176130) Streptococcus pneumoniae G54 6478698 YP_002036891.1 CDS uvrA NC_011072.1 176262 179093 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 176262..179093 Streptococcus pneumoniae G54 6479048 YP_002036892.1 CDS SPG_0177 NC_011072.1 179086 180147 D identified by match to protein family HMM PF00557; match to protein family HMM PF01321; M24 family peptidase 179086..180147 Streptococcus pneumoniae G54 6479220 YP_002036893.1 CDS spxA NC_011072.1 180279 180677 D the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 180279..180677 Streptococcus pneumoniae G54 6479388 YP_002036894.1 CDS SPG_0179 NC_011072.1 180743 181312 D identified by glimmer; putative; hypothetical protein 180743..181312 Streptococcus pneumoniae G54 6479196 YP_002036895.1 CDS SPG_0180 NC_011072.1 181399 181665 D identified by glimmer; putative; hypothetical protein 181399..181665 Streptococcus pneumoniae G54 6479574 YP_002036896.1 CDS SPG_0181 NC_011072.1 181669 182088 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 181669..182088 Streptococcus pneumoniae G54 6479840 YP_002036897.1 CDS SPG_0182 NC_011072.1 182104 182409 D identified by match to protein family HMM PF06949; hypothetical protein 182104..182409 Streptococcus pneumoniae G54 6480784 YP_002036898.1 CDS SPG_0183 NC_011072.1 182542 182718 R identified by glimmer; putative; hypothetical protein complement(182542..182718) Streptococcus pneumoniae G54 6480339 YP_002036899.1 CDS SPG_0184 NC_011072.1 182863 184119 D identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; dihydrofolate folylpolyglutamate synthetase 182863..184119 Streptococcus pneumoniae G54 6479571 YP_002036900.1 CDS SPG_0185 NC_011072.1 184116 184661 D hypothetical protein 184116..184661 Streptococcus pneumoniae G54 6479198 YP_002036901.1 CDS cls NC_011072.1 184807 186339 D identified by match to protein family HMM PF00614; cardiolipin synthase 184807..186339 Streptococcus pneumoniae G54 6480188 YP_002036902.1 CDS SPG_0187 NC_011072.1 186417 186560 D hypothetical protein 186417..186560 Streptococcus pneumoniae G54 6478920 YP_002036903.1 CDS SPG_0188 NC_011072.1 186597 188135 D identified by glimmer; putative; hypothetical protein 186597..188135 Streptococcus pneumoniae G54 6480313 YP_002036904.1 CDS nrdD NC_011072.1 188255 190462 D Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 188255..190462 Streptococcus pneumoniae G54 6480612 YP_002036905.1 CDS SPG_0190 NC_011072.1 190474 190614 D hypothetical protein 190474..190614 Streptococcus pneumoniae G54 6480238 YP_002036906.1 CDS SPG_0191 NC_011072.1 190658 191164 D identified by match to protein family HMM PF00583; GNAT family acetyltransferase 190658..191164 Streptococcus pneumoniae G54 6479403 YP_002036907.1 CDS nrdG NC_011072.1 191157 191747 D identified by match to protein family HMM PF04055; match to protein family HMM TIGR02491; anaerobic ribonucleoside-triphosphate reductase activating protein 191157..191747 Streptococcus pneumoniae G54 6480063 YP_002036908.1 CDS SPG_0193 NC_011072.1 191744 192361 D identified by glimmer; putative; hypothetical protein 191744..192361 Streptococcus pneumoniae G54 6480758 YP_002036909.1 CDS rpsJ NC_011072.1 192627 192935 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 192627..192935 Streptococcus pneumoniae G54 6480404 YP_002036910.1 CDS rplC NC_011072.1 193151 193777 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 193151..193777 Streptococcus pneumoniae G54 6479160 YP_002036911.1 CDS rplD NC_011072.1 193802 194425 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 193802..194425 Streptococcus pneumoniae G54 6480532 YP_002036912.1 CDS rplW NC_011072.1 194425 194721 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 194425..194721 Streptococcus pneumoniae G54 6480711 YP_002036913.1 CDS rplB NC_011072.1 194739 195572 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 194739..195572 Streptococcus pneumoniae G54 6480429 YP_002036914.1 CDS rpsS NC_011072.1 195676 195957 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 195676..195957 Streptococcus pneumoniae G54 6479725 YP_002036915.1 CDS rplV NC_011072.1 195969 196313 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 195969..196313 Streptococcus pneumoniae G54 6479170 YP_002036916.1 CDS rpsC NC_011072.1 196326 196979 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 196326..196979 Streptococcus pneumoniae G54 6480762 YP_002036917.1 CDS rplP NC_011072.1 196983 197396 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 196983..197396 Streptococcus pneumoniae G54 6478763 YP_002036918.1 CDS rpmC NC_011072.1 197406 197612 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 197406..197612 Streptococcus pneumoniae G54 6479833 YP_002036919.1 CDS rpsQ NC_011072.1 197637 197897 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 197637..197897 Streptococcus pneumoniae G54 6479352 YP_002036920.1 CDS rplN NC_011072.1 197923 198291 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 197923..198291 Streptococcus pneumoniae G54 6479277 YP_002036921.1 CDS rplX NC_011072.1 198369 198674 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 198369..198674 Streptococcus pneumoniae G54 6478787 YP_002036922.1 CDS rplE NC_011072.1 198698 199240 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 198698..199240 Streptococcus pneumoniae G54 6479049 YP_002036923.1 CDS rpsN NC_011072.1 199258 199527 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 199258..199527 Streptococcus pneumoniae G54 6480224 YP_002036924.1 CDS rpsH NC_011072.1 199812 200210 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 199812..200210 Streptococcus pneumoniae G54 6479964 YP_002036925.1 CDS rplF NC_011072.1 200402 200938 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 200402..200938 Streptococcus pneumoniae G54 6478745 YP_002036926.1 CDS rplR NC_011072.1 201022 201378 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 201022..201378 Streptococcus pneumoniae G54 6478749 YP_002036927.1 CDS rpsE NC_011072.1 201396 201890 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 201396..201890 Streptococcus pneumoniae G54 6479278 YP_002036928.1 CDS rpmD NC_011072.1 201904 202086 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 201904..202086 Streptococcus pneumoniae G54 6479239 YP_002036929.1 CDS rplO NC_011072.1 202231 202671 D late assembly protein; 50S ribosomal protein L15 202231..202671 Streptococcus pneumoniae G54 6480274 YP_002036930.1 CDS secY NC_011072.1 202684 203994 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 202684..203994 Streptococcus pneumoniae G54 6480810 YP_002036931.1 CDS adk NC_011072.1 204145 204783 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 204145..204783 Streptococcus pneumoniae G54 6480446 YP_002036932.1 CDS infA NC_011072.1 204900 205118 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 204900..205118 Streptococcus pneumoniae G54 6478943 YP_002036933.2 CDS rpsM NC_011072.1 <205356 205643 D truncated; contains potential frameshift; identified by match to protein family HMM PF00416; 30S ribosomal protein S13 <205356..205643 Streptococcus pneumoniae G54 6480000 YP_002036934.1 CDS rpsK NC_011072.1 205661 206044 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 205661..206044 Streptococcus pneumoniae G54 6478720 YP_002036935.1 CDS rpoA NC_011072.1 206087 207022 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 206087..207022 Streptococcus pneumoniae G54 6480400 YP_002036936.1 CDS rplQ NC_011072.1 207034 207420 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 207034..207420 Streptococcus pneumoniae G54 6480275 YP_002036937.1 CDS SPG_0222 NC_011072.1 207685 207951 D ACT domain-containing protein; hypothetical protein 207685..207951 Streptococcus pneumoniae G54 6479546 YP_002036938.1 CDS SPG_0223 NC_011072.1 207961 209298 D identified by match to protein family HMM PF05167; hypothetical protein 207961..209298 Streptococcus pneumoniae G54 6479758 YP_002036939.1 CDS SPG_0224 NC_011072.1 209542 210234 D identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein 209542..210234 Streptococcus pneumoniae G54 6480558 YP_002036940.1 CDS pitA1 NC_011072.1 210337 210750 R contains potential frameshift; Ulijasz AT, J Bacteriol. 2004 Dec;186(23):8123-36.; iron ABC transporter permease complement(210337..210750) Streptococcus pneumoniae G54 6480485 YP_002036941.1 CDS pitA2 NC_011072.1 210747 211319 R contains potential frameshift; Ulijasz AT, J Bacteriol. 2004 Dec;186(23):8123-36.; iron ABC transporter permease complement(210747..211319) Streptococcus pneumoniae G54 6478852 YP_002036942.1 CDS pitD NC_011072.1 211346 211714 R Ulijasz AT, J Bacteriol. 2004 Dec;186(23):8123-36.; iron ABC transporter permease complement(211346..211714) Streptococcus pneumoniae G54 6478752 YP_002036943.1 CDS pitB NC_011072.1 211962 213053 R Ulijasz AT, J Bacteriol. 2004 Dec;186(23):8123-36.; identified by match to protein family HMM PF00005; match to protein family HMM PF08402; iron ABC transporter ATP-binding protein complement(211962..213053) Streptococcus pneumoniae G54 6478810 YP_002036944.1 CDS SPG_0229 NC_011072.1 213066 213434 R contains potential frameshift; iron ABC transporter iron-binding protein complement(213066..213434) Streptococcus pneumoniae G54 6480763 YP_002036945.1 CDS SPG_0230 NC_011072.1 213579 214187 R contains potential frameshift; iron ABC transporter iron-binding protein complement(213579..214187) Streptococcus pneumoniae G54 6480053 YP_002036946.1 CDS SPG_0231 NC_011072.1 214404 214601 R identified by match to protein family HMM PF00165; hypothetical protein complement(214404..214601) Streptococcus pneumoniae G54 6480278 YP_002036947.1 CDS SPG_0232 NC_011072.1 214676 215452 R identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494; glycyl-radical enzyme activating family protein complement(214676..215452) Streptococcus pneumoniae G54 6478828 YP_002036948.1 CDS SPG_0233 NC_011072.1 215574 216320 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; transcriptional regulator 215574..216320 Streptococcus pneumoniae G54 6480288 YP_002036949.1 CDS SPG_0234 NC_011072.1 216333 217313 D identified by match to protein family HMM PF04198; transcriptional regulator 216333..217313 Streptococcus pneumoniae G54 6479214 YP_002036950.1 CDS SPG_0235 NC_011072.1 217508 217828 D identified by match to protein family HMM PF02255; PTS system transporter subunit IIA 217508..217828 Streptococcus pneumoniae G54 6479545 YP_002036951.1 CDS SPG_0236 NC_011072.1 217874 218182 D identified by match to protein family HMM PF02302; PTS system transporter subunit IIB 217874..218182 Streptococcus pneumoniae G54 6480355 YP_002036952.1 CDS SPG_0237 NC_011072.1 218199 219497 D identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; PTS system transporter subunit IIC 218199..219497 Streptococcus pneumoniae G54 6480306 YP_002036953.1 CDS SPG_0238 NC_011072.1 219648 222086 D identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01774; pyruvate formate-lyase 219648..222086 Streptococcus pneumoniae G54 6479921 YP_002036954.1 CDS SPG_0239 NC_011072.1 222105 222773 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 222105..222773 Streptococcus pneumoniae G54 6480548 YP_002036955.1 CDS gldA NC_011072.1 222791 223879 D forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 222791..223879 Streptococcus pneumoniae G54 6480484 YP_002036956.1 CDS leuS NC_011072.1 224334 226835 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 224334..226835 Streptococcus pneumoniae G54 6479470 YP_002036957.1 CDS SPG_0242 NC_011072.1 227029 227724 D identified by match to protein family HMM PF00583; GNAT family acetyltransferase 227029..227724 Streptococcus pneumoniae G54 6480171 YP_002036958.1 CDS SPG_0243 NC_011072.1 227736 228152 D identified by match to protein family HMM PF00583; GNAT family acetyltransferase 227736..228152 Streptococcus pneumoniae G54 6479247 YP_002036959.1 CDS ruvB NC_011072.1 229193 230191 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 229193..230191 Streptococcus pneumoniae G54 6479488 YP_002036960.1 CDS SPG_0245 NC_011072.1 230172 230744 D identified by match to protein family HMM PF06042; hypothetical protein 230172..230744 Streptococcus pneumoniae G54 6478739 YP_002036961.1 CDS SPG_0246 NC_011072.1 230975 231733 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 230975..231733 Streptococcus pneumoniae G54 6480231 YP_002036962.1 CDS cdsA NC_011072.1 231742 232545 D identified by match to protein family HMM PF01148; phosphatidate cytidylyltransferase 231742..232545 Streptococcus pneumoniae G54 6480029 YP_002036963.1 CDS SPG_0248 NC_011072.1 232567 233826 D identified by match to protein family HMM PF02163; match to protein family HMM TIGR00054; M50 family peptidase 232567..233826 Streptococcus pneumoniae G54 6479819 YP_002036964.1 CDS proS NC_011072.1 233839 235692 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 233839..235692 Streptococcus pneumoniae G54 6479978 YP_002036965.1 CDS SPG_0250 NC_011072.1 235791 237170 D identified by match to protein family HMM PF00232; glycosyl hydrolase family protein 235791..237170 Streptococcus pneumoniae G54 6479206 YP_002036966.1 CDS glmS NC_011072.1 237363 239171 D Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 237363..239171 Streptococcus pneumoniae G54 6479949 YP_002036967.1 CDS SPG_0252 NC_011072.1 239290 240339 D identified by glimmer; putative; hypothetical protein 239290..240339 Streptococcus pneumoniae G54 6479173 YP_002036968.1 CDS pulA NC_011072.1 240439 244281 R identified by match to protein family HMM PF00128; match to protein family HMM PF00746; match to protein family HMM PF02922; match to protein family HMM PF03714; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; match to protein family HMM TIGR02102; alkaline amylopullulanase complement(240439..244281) Streptococcus pneumoniae G54 6478891 YP_002036969.1 CDS rpsL NC_011072.1 244698 245111 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 244698..245111 Streptococcus pneumoniae G54 6480725 YP_002036970.1 CDS rpsG NC_011072.1 245131 245601 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 245131..245601 Streptococcus pneumoniae G54 6480217 YP_002036971.1 CDS SPG_0256 NC_011072.1 246026 248107 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 246026..248107 Streptococcus pneumoniae G54 6479012 YP_002036972.1 CDS polC NC_011072.1 248211 252602 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 248211..252602 Streptococcus pneumoniae G54 6479387 YP_002036973.1 CDS SPG_0258 NC_011072.1 252704 252967 D identified by match to protein family HMM PF04221; match to protein family HMM TIGR02384; RelB/DinJ family addiction module antitoxin 252704..252967 Streptococcus pneumoniae G54 6480178 YP_002036974.1 CDS SPG_0259 NC_011072.1 252960 253238 D identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; RelE/StbE family addiction module toxin 252960..253238 Streptococcus pneumoniae G54 6479441 YP_002036975.1 CDS SPG_0260 NC_011072.1 253259 253411 D hypothetical protein 253259..253411 Streptococcus pneumoniae G54 6478819 YP_002036976.1 CDS SPG_0261 NC_011072.1 253433 254674 D identified by match to protein family HMM PF02073; aminopeptidase PepS 253433..254674 Streptococcus pneumoniae G54 6479820 YP_002036977.1 CDS SPG_0262 NC_011072.1 254684 254914 D identified by match to protein family HMM PF04226; hypothetical protein 254684..254914 Streptococcus pneumoniae G54 6479181 YP_002036978.1 CDS SPG_0263 NC_011072.1 255227 255949 D identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A 255227..255949 Streptococcus pneumoniae G54 6480799 YP_002036979.1 CDS SPG_0264 NC_011072.1 256166 257500 D identified by match to protein family HMM PF03051; aminopeptidase C 256166..257500 Streptococcus pneumoniae G54 6479454 YP_002036980.1 CDS SPG_0265 NC_011072.1 257556 258467 R identified by match to protein family HMM PF03613; match to protein family HMM TIGR00828; PTS system transporter subunit IID complement(257556..258467) Streptococcus pneumoniae G54 6480401 YP_002036981.1 CDS SPG_0266 NC_011072.1 258491 259294 R identified by match to protein family HMM PF03609; PTS system transporter subunit IIC complement(258491..259294) Streptococcus pneumoniae G54 6479477 YP_002036982.1 CDS SPG_0267 NC_011072.1 259322 260311 R identified by match to protein family HMM PF03610; match to protein family HMM PF03830; PTS system transporter subunit IIAB complement(259322..260311) Streptococcus pneumoniae G54 6479514 YP_002036983.1 CDS adhP NC_011072.1 260545 261564 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(260545..261564) Streptococcus pneumoniae G54 6479951 YP_002036984.1 CDS SPG_0269 NC_011072.1 261673 261819 R identified by glimmer; putative; hypothetical protein complement(261673..261819) Streptococcus pneumoniae G54 6478642 YP_002036985.1 CDS SPG_0270 NC_011072.1 261903 262286 R contains potential frameshift; identified by match to protein family HMM PF08282; hydrolase complement(261903..262286) Streptococcus pneumoniae G54 6478662 YP_002036986.1 CDS SPG_0271 NC_011072.1 262381 262716 R contains potential frameshift; hydrolase complement(262381..262716) Streptococcus pneumoniae G54 6480823 YP_002036987.1 CDS SPG_0272 NC_011072.1 262906 264324 D identified by match to protein family HMM PF00860; putative permease 262906..264324 Streptococcus pneumoniae G54 6480183 YP_002036988.1 CDS SPG_0273 NC_011072.1 264377 265084 D identified by match to protein family HMM PF02517; CAAX amino terminal protease family 264377..265084 Streptococcus pneumoniae G54 6479755 YP_002036989.1 CDS sulA NC_011072.1 265179 266153 D identified by match to protein family HMM PF00809; match to protein family HMM TIGR01496; dihydropteroate synthase 265179..266153 Streptococcus pneumoniae G54 6480800 YP_002036990.1 CDS sulB NC_011072.1 266155 267477 D identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; dihydrofolate synthetase 266155..267477 Streptococcus pneumoniae G54 6480722 YP_002036991.1 CDS folE NC_011072.1 267458 268012 D involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 267458..268012 Streptococcus pneumoniae G54 6479991 YP_002036992.1 CDS sulD NC_011072.1 268055 268867 D identified by match to protein family HMM PF01288; match to protein family HMM PF02152; match to protein family HMM TIGR00525; match to protein family HMM TIGR00526; match to protein family HMM TIGR01498; bifunctional folate synthesis protein 268055..268867 Streptococcus pneumoniae G54 6479597 YP_002036993.1 CDS SPG_0278 NC_011072.1 268912 269229 R hypothetical protein complement(268912..269229) Streptococcus pneumoniae G54 6478776 YP_002036994.1 CDS rplM NC_011072.1 269750 270031 D contains potential frameshift; identified by match to protein family HMM PF00572; match to protein family HMM TIGR01066; 50S ribosomal protein L13 269750..270031 Streptococcus pneumoniae G54 6480085 YP_002036995.1 CDS rpsI NC_011072.1 270050 270442 D forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 270050..270442 Streptococcus pneumoniae G54 6478844 YP_002036996.1 CDS SPG_0281 NC_011072.1 270703 271125 R identified by match to protein family HMM PF00589; phage integrase family integrase/recombinase complement(270703..271125) Streptococcus pneumoniae G54 6480093 YP_002036997.1 CDS SPG_0282 NC_011072.1 271272 271448 D hypothetical protein 271272..271448 Streptococcus pneumoniae G54 6480716 YP_002036998.1 CDS SPG_0283 NC_011072.1 271849 274062 D identified by match to protein family HMM PF01055; family 31 glycosyl hydrolase 271849..274062 Streptococcus pneumoniae G54 6478683 YP_002036999.1 CDS SPG_0284 NC_011072.1 274284 274760 R identified by match to protein family HMM PF00255; glutathione peroxidase complement(274284..274760) Streptococcus pneumoniae G54 6479598 YP_002037000.1 CDS hyl NC_011072.1 274983 278186 D identified by match to protein family HMM PF00746; match to protein family HMM PF02018; match to protein family HMM PF02278; match to protein family HMM PF02884; match to protein family HMM PF08124; match to protein family HMM TIGR01167; hyaluronate lyase Hyl 274983..278186 Streptococcus pneumoniae G54 6479778 YP_002037001.1 CDS SPG_0286 NC_011072.1 278802 278927 D IS200S transposase 278802..278927 Streptococcus pneumoniae G54 6479156 YP_002037002.1 CDS eda NC_011072.1 279303 279932 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(279303..279932) Streptococcus pneumoniae G54 6480602 YP_002037003.1 CDS SPG_0288 NC_011072.1 279942 280943 R carbohydrate kinase, PfkB family; identified by match to protein family HMM PF00294; 2-dehydro-3-deoxygluconatekinase complement(279942..280943) Streptococcus pneumoniae G54 6479924 YP_002037004.1 CDS SPG_0289 NC_011072.1 280974 281615 R identified by match to protein family HMM PF02502; hypothetical protein complement(280974..281615) Streptococcus pneumoniae G54 6478809 YP_002037005.1 CDS SPG_0290 NC_011072.1 281634 282449 R Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase complement(281634..282449) Streptococcus pneumoniae G54 6479760 YP_002037006.1 CDS SPG_0291 NC_011072.1 282720 283148 D identified by match to protein family HMM PF03610; PTS system transporter subunit IIA 282720..283148 Streptococcus pneumoniae G54 6479453 YP_002037007.1 CDS SPG_0292 NC_011072.1 283160 284350 D identified by match to protein family HMM PF07470; unsaturated glucuronyl hydrolase 283160..284350 Streptococcus pneumoniae G54 6480449 YP_002037008.1 CDS SPG_0293 NC_011072.1 284361 284852 D identified by match to protein family HMM PF03830; PTS system transporter subunit IIB 284361..284852 Streptococcus pneumoniae G54 6478884 YP_002037009.1 CDS SPG_0294 NC_011072.1 284867 285646 D identified by match to protein family HMM PF03609; PTS system transporter subunit IIC 284867..285646 Streptococcus pneumoniae G54 6480633 YP_002037010.1 CDS SPG_0295 NC_011072.1 285633 286451 D identified by match to protein family HMM PF03613; PTS system transporter subunit IID 285633..286451 Streptococcus pneumoniae G54 6479182 YP_002037011.1 CDS SPG_0296 NC_011072.1 286451 286744 D identified by match to protein family HMM PF02699; match to protein family HMM TIGR00739; preprotein translocase subunit 286451..286744 Streptococcus pneumoniae G54 6479816 YP_002037012.1 CDS SPG_0297 NC_011072.1 286766 288667 D identified by match to protein family HMM PF07940; hypothetical protein 286766..288667 Streptococcus pneumoniae G54 6479089 YP_002037013.1 CDS regR NC_011072.1 288727 289728 D Chapuy-Regaud,S.; (2003)Inf.& Imm. 71: 2615-2625; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sugar binding transcriptional regulator RegR 288727..289728 Streptococcus pneumoniae G54 6480263 YP_002037014.1 CDS SPG_0299 NC_011072.1 289838 290173 R hypothetical protein complement(289838..290173) Streptococcus pneumoniae G54 6478737 YP_002037015.1 CDS SPG_0300 NC_011072.1 290184 290426 R hypothetical protein complement(290184..290426) Streptococcus pneumoniae G54 6479780 YP_002037016.1 CDS SPG_0301 NC_011072.1 290437 290979 R identified by glimmer; putative; hypothetical protein complement(290437..290979) Streptococcus pneumoniae G54 6480340 YP_002037017.1 CDS SPG_0302 NC_011072.1 290995 291189 R identified by match to protein family HMM PF01381; transcriptional regulator complement(290995..291189) Streptococcus pneumoniae G54 6479648 YP_002037018.1 CDS mraW NC_011072.1 291355 292305 D identified by match to protein family HMM PF01795; match to protein family HMM TIGR00006; S-adenosyl-methyltransferase MraW 291355..292305 Streptococcus pneumoniae G54 6479519 YP_002037019.1 CDS SPG_0304 NC_011072.1 292317 292634 D identified by match to protein family HMM TIGR02209; cell division protein FtsL 292317..292634 Streptococcus pneumoniae G54 6480088 YP_002037020.1 CDS pbp2X NC_011072.1 292638 294890 D identified by match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM PF03793; penicillin-binding protein 2X 292638..294890 Streptococcus pneumoniae G54 6480227 YP_002037021.1 CDS mraY NC_011072.1 294892 295872 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 294892..295872 Streptococcus pneumoniae G54 6479297 YP_002037022.1 CDS SPG_0307 NC_011072.1 296084 296200 D hypothetical protein 296084..296200 Streptococcus pneumoniae G54 6480382 YP_002037023.1 CDS SPG_0308 NC_011072.1 296481 298586 D identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; ATP-dependent Clp protease ATP-binding subunit 296481..298586 Streptococcus pneumoniae G54 6479860 YP_002037024.1 CDS luxS NC_011072.1 298882 299364 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(298882..299364) Streptococcus pneumoniae G54 6480079 YP_002037025.1 CDS SPG_0310 NC_011072.1 299459 300943 R identified by match to protein family HMM PF08903; hypothetical protein complement(299459..300943) Streptococcus pneumoniae G54 6479611 YP_002037026.1 CDS dexB NC_011072.1 301096 302703 D identified by match to protein family HMM PF00128; glucan 1,6-alpha-glucosidase 301096..302703 Streptococcus pneumoniae G54 6479030 YP_002037027.1 CDS SPG_0312 NC_011072.1 302862 303035 D identified by glimmer; putative; hypothetical protein 302862..303035 Streptococcus pneumoniae G54 6479767 YP_002037028.1 CDS SPG_0313 NC_011072.1 303258 303383 D identified by glimmer; putative; hypothetical protein 303258..303383 Streptococcus pneumoniae G54 6478757 YP_002037029.1 CDS cpsA NC_011072.1 303775 305220 D Bentley, S.D.; 2006 PLOS Genetics 2: 0262-0269 Guidolin,A.; 1994 Inf.Imm. 62:5384-5396; identified by match to protein family HMM PF02916; match to protein family HMM PF03816; match to protein family HMM TIGR00350; integral membrane regulatory protein Wzg 303775..305220 Streptococcus pneumoniae G54 6478997 YP_002037030.1 CDS cpsB NC_011072.1 305222 305953 D Bentley, S.D.; 2006 PLOS Genetics 2: 0262-0269 Guidolin,A.; 1994 Inf.Imm. 62:5384-5396; identified by match to protein family HMM PF02811; tyrosine-protein phosphatase wzh 305222..305953 Streptococcus pneumoniae G54 6479425 YP_002037031.1 CDS cpsC NC_011072.1 305962 306654 D Bentley, S.D.; 2006 PLOS Genetics 2: 0262-0269 Guidolin,A.; 1994 Inf.Imm. 62:5384-5396; identified by match to protein family HMM PF02706; match to protein family HMM TIGR01006; capsular polysaccharide biosynthesis protein Wzh 305962..306654 Streptococcus pneumoniae G54 6478888 YP_002037032.1 CDS cpsD NC_011072.1 306664 307347 D Bentley, S.D.; 2006 PLOS Genetics 2: 0262-0269 Guidolin,A.; 1994 Inf.Imm. 62:5384-5396; identified by match to protein family HMM TIGR01007; tyrosine-protein kinase wze 306664..307347 Streptococcus pneumoniae G54 6480202 YP_002037033.1 CDS cpsE NC_011072.1 307363 308730 D identified by match to protein family HMM PF02397; match to protein family HMM TIGR03025; undecaprenylphosphate glucosephosphotransferase WchA 307363..308730 Streptococcus pneumoniae G54 6480307 YP_002037034.1 CDS cpsF NC_011072.1 308734 309477 D Bentley, S.D.; 2006 PLOS Genetics 2: 0262-0269 Guidolin,A.; 1994 Inf.Imm. 62:5384-5396; identified by match to protein family HMM PF03808; match to protein family HMM TIGR00696; UDP-N-acetyl-D-mannosamine transferase wchO 308734..309477 Streptococcus pneumoniae G54 6479979 YP_002037035.1 CDS cpsG NC_011072.1 309474 310298 D Bentley, S.D.; 2006 PLOS Genetics 2: 0262-0269 Guidolin,A.; 1994 Inf.Imm. 62:5384-5396; identified by match to protein family HMM PF04991; putative LicD-family phosphotransferase wchP 309474..310298 Streptococcus pneumoniae G54 6479304 YP_002037036.1 CDS cpsH NC_011072.1 310300 311178 D Bentley, S.D.; 2006 PLOS Genetics 2: 0262-0269 Guidolin,A.; 1994 Inf.Imm. 62:5384-5396; identified by match to protein family HMM PF00535; putative rhamnosyl transferase wchQ 310300..311178 Streptococcus pneumoniae G54 6480781 YP_002037037.1 CDS cpsI NC_011072.1 311179 312516 D Bentley, S.D.; 2006 PLOS Genetics 2: 0262-0269 Guidolin,A.; 1994 Inf.Imm. 62:5384-5396; oligosaccharide repeat unit polymerase Wzy 311179..312516 Streptococcus pneumoniae G54 6479031 YP_002037038.1 CDS cpsJ NC_011072.1 312539 313960 D Bentley, S.D.; 2006 PLOS Genetics 2: 0262-0269 Guidolin,A.; 1994 Inf.Imm. 62:5384-5396; flippase Wzx 312539..313960 Streptococcus pneumoniae G54 6479267 YP_002037039.1 CDS cpsK NC_011072.1 314024 315112 D Bentley, S.D.; 2006 PLOS Genetics 2: 0262-0269 Guidolin,A.; 1994 Inf.Imm. 62:5384-5396; identified by match to protein family HMM PF02350; match to protein family HMM TIGR00236; UDP-N-acetylglucosamine 2-epimerase mnaA 314024..315112 Streptococcus pneumoniae G54 6480146 YP_002037040.1 CDS cpsL NC_011072.1 315151 316020 D Bentley, S.D.; 2006 PLOS Genetics 2: 0262-0269 Guidolin,A.; 1994 Inf.Imm. 62:5384-5396; identified by match to protein family HMM PF00483; match to protein family HMM TIGR01207; glucose-1-phosphate thymidyl transferase rmlA 315151..316020 Streptococcus pneumoniae G54 6479905 YP_002037041.1 CDS cpsM NC_011072.1 316021 316617 D Bentley, S.D.; 2006 PLOS Genetics 2: 0262-0269 Guidolin,A.; 1994 Inf.Imm. 62:5384-5396; identified by match to protein family HMM PF00908; dTDP-4-keto-6-deoxyglucose-3,5-epimerase RmlC 316021..316617 Streptococcus pneumoniae G54 6479199 YP_002037042.1 CDS cpsN NC_011072.1 316627 317676 D identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181; dTDP-glucose 4,6-dehydratase RmlB 316627..317676 Streptococcus pneumoniae G54 6480561 YP_002037043.1 CDS cpsO NC_011072.1 317742 318593 D Bentley, S.D.; 2006 PLOS Genetics 2: 0262-0269 Guidolin,A.; 1994 Inf.Imm. 62:5384-5396; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01214; dTDP-4-keto-L-rhamnose reductase RmlD 317742..318593 Streptococcus pneumoniae G54 6479051 YP_002037044.1 CDS SPG_0329 NC_011072.1 318656 319102 D identified by match to protein family HMM PF03050; IS66-Spn1 transposase 318656..319102 Streptococcus pneumoniae G54 6480476 YP_002037045.1 CDS SPG_0330 NC_011072.1 319412 319624 D IS66-Spn1 transposase 319412..319624 Streptococcus pneumoniae G54 6480226 YP_002037046.1 CDS SPG_0331 NC_011072.1 319695 319853 D IS66-Spn1 transposase 319695..319853 Streptococcus pneumoniae G54 6480395 YP_002037047.1 CDS aliA NC_011072.1 320052 322034 D identified by match to protein family HMM PF00496; oligopeptide ABC transporter substrate-binding protein 320052..322034 Streptococcus pneumoniae G54 6479093 YP_002037048.1 CDS SPG_0333 NC_011072.1 322335 327638 D identified by match to protein family HMM PF00754; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; cell wall surface anchor family protein 322335..327638 Streptococcus pneumoniae G54 6480777 YP_002037049.1 CDS SPG_0334 NC_011072.1 327805 329964 R identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 1A complement(327805..329964) Streptococcus pneumoniae G54 6479083 YP_002037050.1 CDS recU NC_011072.1 329961 330557 R functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease complement(329961..330557) Streptococcus pneumoniae G54 6479961 YP_002037051.1 CDS SPG_0336 NC_011072.1 330623 331150 D identified by match to protein family HMM PF06908; hypothetical protein 330623..331150 Streptococcus pneumoniae G54 6478688 YP_002037052.1 CDS SPG_0337 NC_011072.1 331220 331549 D identified by match to protein family HMM PF05103; hypothetical protein 331220..331549 Streptococcus pneumoniae G54 6479542 YP_002037053.1 CDS SPG_0338 NC_011072.1 331554 331667 R identified by glimmer; putative; hypothetical protein complement(331554..331667) Streptococcus pneumoniae G54 6479486 YP_002037054.1 CDS SPG_0339 NC_011072.1 332035 333192 D identified by match to protein family HMM PF01170; hypothetical protein 332035..333192 Streptococcus pneumoniae G54 6478853 YP_002037055.1 CDS SPG_0340 NC_011072.1 333205 334599 D hypothetical protein 333205..334599 Streptococcus pneumoniae G54 6480478 YP_002037056.1 CDS gnd NC_011072.1 334675 336099 D catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 334675..336099 Streptococcus pneumoniae G54 6479673 YP_002037057.1 CDS ritR NC_011072.1 336111 336800 D Ulijasz et al., J Bacteriol. 2004 186(23):8123-36.; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; RitR response regulator 336111..336800 Streptococcus pneumoniae G54 6479772 YP_002037058.1 CDS cbpC NC_011072.1 336898 337917 D identified by match to protein family HMM PF01473; choline-binding protein C 336898..337917 Streptococcus pneumoniae G54 6479692 YP_002037059.1 CDS SPG_0344 NC_011072.1 338035 339267 R hypothetical protein complement(338035..339267) Streptococcus pneumoniae G54 6478894 YP_002037060.1 CDS SPG_0345 NC_011072.1 340966 341145 D identified by match to protein family HMM PF01473; hypothetical protein 340966..341145 Streptococcus pneumoniae G54 6480640 YP_002037061.1 CDS mvaK1 NC_011072.1 341267 342145 D identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR00549; mevalonate kinase 341267..342145 Streptococcus pneumoniae G54 6480697 YP_002037062.1 CDS mvaD NC_011072.1 342127 343080 D identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR01240; mevalonate diphosphate decarboxylase 342127..343080 Streptococcus pneumoniae G54 6478709 YP_002037063.1 CDS mvaK2 NC_011072.1 343067 344074 D identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR01220; phosphomevalonate kinase 343067..344074 Streptococcus pneumoniae G54 6479747 YP_002037064.1 CDS SPG_0349 NC_011072.1 344058 345068 D catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 344058..345068 Streptococcus pneumoniae G54 6480774 YP_002037065.1 CDS SPG_0350 NC_011072.1 345146 345844 D hypothetical protein 345146..345844 Streptococcus pneumoniae G54 6480820 YP_002037066.1 CDS SPG_0351 NC_011072.1 345841 346836 D identified by match to protein family HMM PF02518; match to protein family HMM PF07730; histidine kinase 345841..346836 Streptococcus pneumoniae G54 6478990 YP_002037067.1 CDS SPG_0352 NC_011072.1 346850 347482 D identified by match to protein family HMM PF00072; match to protein family HMM PF00196; match to protein family HMM PF08281; response regulator 346850..347482 Streptococcus pneumoniae G54 6480209 YP_002037068.1 CDS SPG_0353 NC_011072.1 347696 347914 D hypothetical protein 347696..347914 Streptococcus pneumoniae G54 6479484 YP_002037069.1 CDS SPG_0354 NC_011072.1 347969 348241 D DNA alkylation repair enzyme 347969..348241 Streptococcus pneumoniae G54 6479588 YP_002037070.1 CDS SPG_0355 NC_011072.1 348391 348630 D hypothetical protein 348391..348630 Streptococcus pneumoniae G54 6478958 YP_002037071.1 CDS cbpG NC_011072.1 348711 349532 D identified by match to protein family HMM PF00089; match to protein family HMM PF01473; choline binding protein G 348711..349532 Streptococcus pneumoniae G54 6479228 YP_002037072.1 CDS SPG_0357 NC_011072.1 349551 349976 D choline-binding protein F, point mutation 349551..349976 Streptococcus pneumoniae G54 6479375 YP_002037073.1 CDS SPG_0358 NC_011072.1 350094 350573 D identified by match to protein family HMM PF01473; choline-binding protein F, point mutation 350094..350573 Streptococcus pneumoniae G54 6479728 YP_002037074.1 CDS SPG_0359 NC_011072.1 350701 350850 R IS3-Spn1 transposase complement(350701..350850) Streptococcus pneumoniae G54 6479528 YP_002037075.1 CDS SPG_0360 NC_011072.1 350834 351187 R IS3-Spn1 transposase complement(350834..351187) Streptococcus pneumoniae G54 6480672 YP_002037076.1 CDS SPG_0361 NC_011072.1 351409 351924 R identified by match to protein family HMM PF01527; IS3-Spn1 transposase complement(351409..351924) Streptococcus pneumoniae G54 6478676 YP_002037077.1 CDS SPG_0362 NC_011072.1 352133 353890 D identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00851; PTS system transporter subunit IIBC 352133..353890 Streptococcus pneumoniae G54 6478783 YP_002037078.1 CDS SPG_0363 NC_011072.1 353914 355869 D identified by match to protein family HMM PF08279; putative transcriptional regulator MtlR 353914..355869 Streptococcus pneumoniae G54 6480162 YP_002037079.1 CDS SPG_0364 NC_011072.1 355871 356308 D identified by match to protein family HMM PF00359; PTS system transporter subunit IIA 355871..356308 Streptococcus pneumoniae G54 6479903 YP_002037080.1 CDS SPG_0365 NC_011072.1 356370 357506 D identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol-1-phosphate 5-dehydrogenase 356370..357506 Streptococcus pneumoniae G54 6478924 YP_002037081.1 CDS SPG_0366 NC_011072.1 357875 357988 D hypothetical protein 357875..357988 Streptococcus pneumoniae G54 6480277 YP_002037082.1 CDS tig NC_011072.1 358292 359575 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 358292..359575 Streptococcus pneumoniae G54 6479243 YP_002037083.1 CDS SPG_0368 NC_011072.1 359623 361989 R identified by match to protein family HMM TIGR01448; helicase, RecD/TraA family complement(359623..361989) Streptococcus pneumoniae G54 6480593 YP_002037084.1 CDS SPG_0369 NC_011072.1 362268 362882 R identified by match to protein family HMM PF00717; match to protein family HMM TIGR02227; signal peptidase I complement(362268..362882) Streptococcus pneumoniae G54 6479485 YP_002037085.1 CDS rnhC NC_011072.1 362886 363767 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII complement(362886..363767) Streptococcus pneumoniae G54 6480457 YP_002037086.1 CDS SPG_0371 NC_011072.1 363854 364156 D hypothetical protein 363854..364156 Streptococcus pneumoniae G54 6478804 YP_002037087.1 CDS cvpA NC_011072.1 364153 364701 D identified by match to protein family HMM PF02674; CvpA family protein 364153..364701 Streptococcus pneumoniae G54 6480502 YP_002037088.1 CDS SPG_0373 NC_011072.1 364805 367141 D function of MutS2 is unknown. It should not be considered a DNA mismactch repair. MutS2 lineage is currently functionally uncharacterized.; identified by match to protein family HMM PF00488; match to protein family HMM PF01713; match to protein family HMM TIGR01069; MutS2 family protein 364805..367141 Streptococcus pneumoniae G54 6480503 YP_002037089.1 CDS SPG_0374 NC_011072.1 367483 368805 D identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835; sodium:alanine symporter family 367483..368805 Streptococcus pneumoniae G54 6479197 YP_002037090.1 CDS SPG_0375 NC_011072.1 369023 369571 D identified by glimmer; putative; hypothetical protein 369023..369571 Streptococcus pneumoniae G54 6479027 YP_002037091.1 CDS SPG_0376 NC_011072.1 369681 370580 D identified by match to protein family HMM PF03595; exfoliative toxin A 369681..370580 Streptococcus pneumoniae G54 6479732 YP_002037092.1 CDS serS NC_011072.1 370605 371879 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(370605..371879) Streptococcus pneumoniae G54 6478792 YP_002037093.1 CDS SPG_0378 NC_011072.1 372093 372464 R identified by match to protein family HMM PF06115; hypothetical protein complement(372093..372464) Streptococcus pneumoniae G54 6479716 YP_002037094.1 CDS SPG_0379 NC_011072.1 372467 373831 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase complement(372467..373831) Streptococcus pneumoniae G54 6480699 YP_002037095.1 CDS SPG_0380 NC_011072.1 373915 374208 R hypothetical protein complement(373915..374208) Streptococcus pneumoniae G54 6480143 YP_002037096.1 CDS fabM NC_011072.1 374200 375009 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 374200..375009 Streptococcus pneumoniae G54 6479178 YP_002037097.1 CDS fabT NC_011072.1 375080 375514 D Sullavik, M.C. 1995 Mol.Med.1:436-446; identified by match to protein family HMM PF01047; match to protein family HMM PF03965; fatty acid biosynthesis transcriptional regulator 375080..375514 Streptococcus pneumoniae G54 6480534 YP_002037098.1 CDS fabH NC_011072.1 375514 376488 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 375514..376488 Streptococcus pneumoniae G54 6479318 YP_002037099.1 CDS acpP NC_011072.1 376548 376772 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 376548..376772 Streptococcus pneumoniae G54 6478650 YP_002037100.1 CDS fabK NC_011072.1 376891 377865 D identified by match to protein family HMM PF03060; match to protein family HMM TIGR03151; enoyl-acyl carrier protein (ACP) reductase II 376891..377865 Streptococcus pneumoniae G54 6479959 YP_002037101.1 CDS fabD NC_011072.1 377858 378778 D identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128; malonyl CoA-acyl carrier protein transacylase 377858..378778 Streptococcus pneumoniae G54 6480245 YP_002037102.1 CDS fabG NC_011072.1 378812 379543 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 378812..379543 Streptococcus pneumoniae G54 6479712 YP_002037103.1 CDS fabF NC_011072.1 379565 380800 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 379565..380800 Streptococcus pneumoniae G54 6480617 YP_002037104.1 CDS accB NC_011072.1 380803 381288 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 380803..381288 Streptococcus pneumoniae G54 6479122 YP_002037105.1 CDS fabZ NC_011072.1 381285 381707 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 381285..381707 Streptococcus pneumoniae G54 6478702 YP_002037106.1 CDS accC NC_011072.1 381719 383086 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 381719..383086 Streptococcus pneumoniae G54 6479414 YP_002037107.1 CDS accD NC_011072.1 383123 383989 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 383123..383989 Streptococcus pneumoniae G54 6480447 YP_002037108.1 CDS accA NC_011072.1 383986 384753 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha 383986..384753 Streptococcus pneumoniae G54 6479706 YP_002037109.1 CDS SPG_0394 NC_011072.1 384912 385097 D hypothetical protein 384912..385097 Streptococcus pneumoniae G54 6480375 YP_002037110.1 CDS SPG_0395 NC_011072.1 385154 385588 D hypothetical protein 385154..385588 Streptococcus pneumoniae G54 6480538 YP_002037111.1 CDS nusB NC_011072.1 385887 386309 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(385887..386309) Streptococcus pneumoniae G54 6479729 YP_002037112.1 CDS SPG_0397 NC_011072.1 386302 386691 R identified by match to protein family HMM PF03780; hypothetical protein complement(386302..386691) Streptococcus pneumoniae G54 6480016 YP_002037113.1 CDS SPG_0398 NC_011072.1 386713 387273 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(386713..387273) Streptococcus pneumoniae G54 6479080 YP_002037114.1 CDS gatB NC_011072.1 387402 388844 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(387402..388844) Streptococcus pneumoniae G54 6480643 YP_002037115.1 CDS gatA NC_011072.1 388844 390310 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(388844..390310) Streptococcus pneumoniae G54 6479893 YP_002037116.1 CDS gatC NC_011072.1 390310 390612 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(390310..390612) Streptococcus pneumoniae G54 6480091 YP_002037117.1 CDS prfC NC_011072.1 390825 392369 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 390825..392369 Streptococcus pneumoniae G54 6480235 YP_002037118.1 CDS rpmB NC_011072.1 393085 393273 D required for 70S ribosome assembly; 50S ribosomal protein L28 393085..393273 Streptococcus pneumoniae G54 6478832 YP_002037119.1 CDS SPG_0404 NC_011072.1 393430 393795 D identified by match to protein family HMM PF03780; hypothetical protein 393430..393795 Streptococcus pneumoniae G54 6479286 YP_002037120.1 CDS SPG_0405 NC_011072.1 393798 395465 D identified by match to protein family HMM PF02734; match to protein family HMM TIGR03599; hypothetical protein 393798..395465 Streptococcus pneumoniae G54 6480406 YP_002037121.1 CDS SPG_0406 NC_011072.1 395509 396765 R identified by match to protein family HMM PF01610; IS1167 transposase complement(395509..396765) Streptococcus pneumoniae G54 6479440 YP_002037122.1 CDS SPG_0407 NC_011072.1 397089 398789 D catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit 397089..398789 Streptococcus pneumoniae G54 6479465 YP_002037123.1 CDS ilvH NC_011072.1 398782 399258 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 398782..399258 Streptococcus pneumoniae G54 6479824 YP_002037124.1 CDS SPG_0409 NC_011072.1 399324 400346 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 399324..400346 Streptococcus pneumoniae G54 6480153 YP_002037125.1 CDS SPG_0410 NC_011072.1 400453 400689 D hypothetical protein 400453..400689 Streptococcus pneumoniae G54 6479789 YP_002037126.1 CDS SPG_0411 NC_011072.1 400927 401283 D hypothetical protein 400927..401283 Streptococcus pneumoniae G54 6479429 YP_002037127.1 CDS SPG_0412 NC_011072.1 401333 402583 D catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 401333..402583 Streptococcus pneumoniae G54 6480671 YP_002037128.1 CDS SPG_0413 NC_011072.1 402725 402913 D hypothetical protein 402725..402913 Streptococcus pneumoniae G54 6479174 YP_002037129.1 CDS SPG_0414 NC_011072.1 403454 403669 D hypothetical protein 403454..403669 Streptococcus pneumoniae G54 6479580 YP_002037130.1 CDS SPG_0415 NC_011072.1 403868 404632 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(403868..404632) Streptococcus pneumoniae G54 6480152 YP_002037131.1 CDS SPG_0416 NC_011072.1 404632 406197 R identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter amino acid-binding protein/permease complement(404632..406197) Streptococcus pneumoniae G54 6479696 YP_002037132.1 CDS SPG_0418 NC_011072.1 406335 408224 D hypothetical protein 406335..408224 Streptococcus pneumoniae G54 6478711 YP_002037133.1 CDS SPG_0417 NC_011072.1 408221 408391 R hypothetical protein complement(408221..408391) Streptococcus pneumoniae G54 6480677 YP_002037134.1 CDS SPG_0419 NC_011072.1 408423 409553 R identified by match to protein family HMM PF02371; transposase complement(408423..409553) Streptococcus pneumoniae G54 6480361 YP_002037135.1 CDS SPG_0420 NC_011072.1 409640 409777 D identified by glimmer; putative; hypothetical protein 409640..409777 Streptococcus pneumoniae G54 6479733 YP_002037136.1 CDS bacA NC_011072.1 409808 410653 D BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 409808..410653 Streptococcus pneumoniae G54 6478854 YP_002037137.1 CDS SPG_0422 NC_011072.1 410646 410774 D hypothetical protein 410646..410774 Streptococcus pneumoniae G54 6480423 YP_002037138.1 CDS dinB NC_011072.1 410800 411861 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(410800..411861) Streptococcus pneumoniae G54 6478655 YP_002037139.1 CDS SPG_0424 NC_011072.1 412209 414533 D identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255; formate acetyltransferase 412209..414533 Streptococcus pneumoniae G54 6480045 YP_002037140.1 CDS SPG_0425 NC_011072.1 414900 415118 R hypothetical protein complement(414900..415118) Streptococcus pneumoniae G54 6479095 YP_002037141.1 CDS SPG_0426 NC_011072.1 415445 415729 R hypothetical protein complement(415445..415729) Streptococcus pneumoniae G54 6480755 YP_002037142.1 CDS SPG_0427 NC_011072.1 416949 417086 D hypothetical protein 416949..417086 Streptococcus pneumoniae G54 6479720 YP_002037143.1 CDS SPG_0428 NC_011072.1 417326 418549 R identified by match to protein family HMM PF00480; ROK family protein complement(417326..418549) Streptococcus pneumoniae G54 6479448 YP_002037144.1 CDS SPG_0429 NC_011072.1 418717 420039 D identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; PTS system transporter subunit IIC 418717..420039 Streptococcus pneumoniae G54 6480004 YP_002037145.1 CDS SPG_0430 NC_011072.1 420041 420235 D contains potential frameshift; hypothetical protein 420041..420235 Streptococcus pneumoniae G54 6479735 YP_002037146.1 CDS SPG_0431 NC_011072.1 420288 421928 D contains potential frameshift; hypothetical protein 420288..421928 Streptococcus pneumoniae G54 6479356 YP_002037147.1 CDS SPG_0432 NC_011072.1 422096 422440 D identified by match to protein family HMM PF02255; PTS system transporter subunit IIA 422096..422440 Streptococcus pneumoniae G54 6479007 YP_002037148.1 CDS SPG_0433 NC_011072.1 422450 423862 D catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 422450..423862 Streptococcus pneumoniae G54 6479803 YP_002037149.1 CDS SPG_0434 NC_011072.1 423931 425610 D identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00410; PTS system transporter subunit IIBC 423931..425610 Streptococcus pneumoniae G54 6479535 YP_002037150.1 CDS SPG_0435 NC_011072.1 425735 427174 R identified by match to protein family HMM PF02386; Trk transporter membrane-spanning protein complement(425735..427174) Streptococcus pneumoniae G54 6478965 YP_002037151.1 CDS trkA NC_011072.1 427178 428527 R involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component complement(427178..428527) Streptococcus pneumoniae G54 6479509 YP_002037152.1 CDS SPG_0437 NC_011072.1 428716 429564 D identified by match to protein family HMM PF01887; hypothetical protein 428716..429564 Streptococcus pneumoniae G54 6479551 YP_002037153.1 CDS SPG_0438 NC_011072.1 429579 430127 D identified by match to protein family HMM PF07155; hypothetical protein 429579..430127 Streptococcus pneumoniae G54 6480389 YP_002037154.1 CDS SPG_0439 NC_011072.1 430448 432130 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 430448..432130 Streptococcus pneumoniae G54 6479566 YP_002037155.1 CDS SPG_0440 NC_011072.1 432115 432945 D identified by match to protein family HMM PF02361; cobalt transport protein 432115..432945 Streptococcus pneumoniae G54 6480304 YP_002037156.1 CDS SPG_0441 NC_011072.1 433138 433641 D identified by match to protein family HMM PF00588; TrmH family RNA methyltransferase 433138..433641 Streptococcus pneumoniae G54 6480105 YP_002037157.1 CDS SPG_0442 NC_011072.1 434094 434657 D hypothetical protein 434094..434657 Streptococcus pneumoniae G54 6480386 YP_002037158.1 CDS SPG_0443 NC_011072.1 434647 435297 D identified by match to protein family HMM PF01569; hypothetical protein 434647..435297 Streptococcus pneumoniae G54 6479715 YP_002037159.1 CDS SPG_0444 NC_011072.1 435325 435714 D hypothetical protein 435325..435714 Streptococcus pneumoniae G54 6480336 YP_002037160.1 CDS SPG_0445 NC_011072.1 435719 436168 D hypothetical protein 435719..436168 Streptococcus pneumoniae G54 6478729 YP_002037161.1 CDS rpoE NC_011072.1 436296 436883 D participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 436296..436883 Streptococcus pneumoniae G54 6478647 YP_002037162.1 CDS SPG_0447 NC_011072.1 436973 437098 R hypothetical protein complement(436973..437098) Streptococcus pneumoniae G54 6478654 YP_002037163.1 CDS pyrG NC_011072.1 437273 438880 D CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 437273..438880 Streptococcus pneumoniae G54 6480533 YP_002037164.1 CDS SPG_0449 NC_011072.1 439439 441070 R identified by match to protein family HMM PF02690; match to protein family HMM TIGR00704; Na/Pi-cotransporter II-related protein complement(439439..441070) Streptococcus pneumoniae G54 6480083 YP_002037165.1 CDS SPG_0450 NC_011072.1 441435 444923 D identified by match to protein family HMM PF00754; match to protein family HMM PF03644; match to protein family HMM PF07523; endo-beta-N-acetylglucosaminidase 441435..444923 Streptococcus pneumoniae G54 6479783 YP_002037166.1 CDS SPG_0451 NC_011072.1 444990 446342 D identified by match to protein family HMM PF00746; match to protein family HMM PF07501; match to protein family HMM PF07554; match to protein family HMM TIGR01167; endo-beta-N-acetylglucosaminidase 444990..446342 Streptococcus pneumoniae G54 6478911 YP_002037167.1 CDS pgk NC_011072.1 446432 447628 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 446432..447628 Streptococcus pneumoniae G54 6480365 YP_002037168.1 CDS SPG_0453 NC_011072.1 447906 448247 R IS1380-Spn1 transposase complement(447906..448247) Streptococcus pneumoniae G54 6480752 YP_002037169.1 CDS SPG_0454 NC_011072.1 448222 449121 R identified by match to protein family HMM PF01609; IS1380-Spn1 transposase complement(448222..449121) Streptococcus pneumoniae G54 6478837 YP_002037170.1 CDS SPG_0455 NC_011072.1 449093 449278 R IS1380-Spn1 transposase complement(449093..449278) Streptococcus pneumoniae G54 6479749 YP_002037171.1 CDS SPG_0456 NC_011072.1 449498 450025 D hypothetical protein 449498..450025 Streptococcus pneumoniae G54 6479680 YP_002037172.1 CDS glnR NC_011072.1 450102 450458 D identified by match to protein family HMM PF00376; HTH-type transcriptional regulator GlnR 450102..450458 Streptococcus pneumoniae G54 6478682 YP_002037173.1 CDS glnA NC_011072.1 450495 451841 D identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; type I glutamine synthetase 450495..451841 Streptococcus pneumoniae G54 6478869 YP_002037174.1 CDS SPG_0459 NC_011072.1 452021 452170 D identified by glimmer; putative; hypothetical protein 452021..452170 Streptococcus pneumoniae G54 6479032 YP_002037175.1 CDS SPG_0460 NC_011072.1 452623 453921 D identified by match to protein family HMM PF01420; type I restriction-modification system subunit S 452623..453921 Streptococcus pneumoniae G54 6480318 YP_002037176.1 CDS SPG_0461 NC_011072.1 454332 455426 R identified by match to protein family HMM PF01420; Type I restriction modification DNA specificity domain complement(454332..455426) Streptococcus pneumoniae G54 6479723 YP_002037177.1 CDS SPG_0462 NC_011072.1 455426 456889 R identified by match to protein family HMM PF02384; match to protein family HMM PF05175; type I restriction-modification system subunit M complement(455426..456889) Streptococcus pneumoniae G54 6479512 YP_002037178.1 CDS SPG_0463 NC_011072.1 456902 459235 R identified by match to protein family HMM PF00270; match to protein family HMM PF04313; match to protein family HMM PF04851; match to protein family HMM PF08463; type I restriction-modification system subunit R complement(456902..459235) Streptococcus pneumoniae G54 6478790 YP_002037179.1 CDS SPG_0464 NC_011072.1 459585 459713 R hypothetical protein complement(459585..459713) Streptococcus pneumoniae G54 6480190 YP_002037180.1 CDS SPG_0465 NC_011072.1 459920 460351 D hypothetical protein 459920..460351 Streptococcus pneumoniae G54 6480475 YP_002037181.1 CDS hrcA NC_011072.1 460515 461549 D Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 460515..461549 Streptococcus pneumoniae G54 6479559 YP_002037182.1 CDS grpE NC_011072.1 461576 462100 D with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 461576..462100 Streptococcus pneumoniae G54 6478712 YP_002037183.1 CDS dnaK NC_011072.1 462580 464403 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 462580..464403 Streptococcus pneumoniae G54 6480525 YP_002037184.1 CDS dnaJ NC_011072.1 465033 466169 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 465033..466169 Streptococcus pneumoniae G54 6480236 YP_002037185.1 CDS SPG_0470 NC_011072.1 466536 466823 R hypothetical protein complement(466536..466823) Streptococcus pneumoniae G54 6480572 YP_002037186.1 CDS SPG_0471 NC_011072.1 466833 467243 R identified by match to protein family HMM PF01230; histidine triad domain-containing protein complement(466833..467243) Streptococcus pneumoniae G54 6479404 YP_002037187.1 CDS SPG_0472 NC_011072.1 467311 468042 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 467311..468042 Streptococcus pneumoniae G54 6480358 YP_002037188.1 CDS SPG_0473 NC_011072.1 468039 469088 D identified by match to protein family HMM PF05975; ABC transporter permease 468039..469088 Streptococcus pneumoniae G54 6479812 YP_002037189.1 CDS blpT NC_011072.1 469256 469585 R De Saizieu, A.; 2000 J.Bact 182:4696-4703; BlpT protein complement(469256..469585) Streptococcus pneumoniae G54 6480266 YP_002037190.1 CDS blpS NC_011072.1 469862 470200 D De Saizieu, A.; 2000 J.Bact 182:4696-4703; identified by match to protein family HMM PF04397; BlpS protein 469862..470200 Streptococcus pneumoniae G54 6480803 YP_002037191.1 CDS blpR NC_011072.1 470205 470942 D de Saizieu A J Bacteriol. 2000 Sep;182(17):4696-703.; identified by match to protein family HMM PF00072; match to protein family HMM PF04397; BlpR response regulator TCS13 470205..470942 Streptococcus pneumoniae G54 6480802 YP_002037192.1 CDS blpH NC_011072.1 470956 472296 D de Saizieu A J Bacteriol. 2000 Sep;182(17):4696-703.; identified by match to protein family HMM PF02518; BlpH histidine kinase TCS13 470956..472296 Streptococcus pneumoniae G54 6479862 YP_002037193.1 CDS blpC NC_011072.1 472367 472495 R De Saizieu, A.; 2000 J.Bact 182:4696-4703; identified by match to protein family HMM PF08128; match to protein family HMM TIGR01847; bacteriocin BlpC complement(472367..472495) Streptococcus pneumoniae G54 6478978 YP_002037194.1 CDS blpB NC_011072.1 472552 473913 R De Saizieu, A.; 2000 J.Bact 182:4696-4703; identified by match to protein family HMM TIGR01000; BlpC ABC transporter complement(472552..473913) Streptococcus pneumoniae G54 6478771 YP_002037195.1 CDS blpA NC_011072.1 473924 476077 R De Saizieu, A.; 2000 J.Bact 182:4696-4703; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193; ABC transporter ATP-binding protein BlpA complement(473924..476077) Streptococcus pneumoniae G54 6480344 YP_002037196.1 CDS blpPQ NC_011072.1 476358 476561 D bacteriocin BlpPQ 476358..476561 Streptococcus pneumoniae G54 6479533 YP_002037197.1 CDS SPG_0482 NC_011072.1 476879 477082 D identified by glimmer; putative; hypothetical protein 476879..477082 Streptococcus pneumoniae G54 6479966 YP_002037198.1 CDS SPG_0483 NC_011072.1 477656 477820 D hypothetical protein 477656..477820 Streptococcus pneumoniae G54 6479592 YP_002037199.1 CDS SPG_0484 NC_011072.1 478116 478487 D IS1381 transposase OrfA 478116..478487 Streptococcus pneumoniae G54 6479594 YP_002037200.1 CDS SPG_0485 NC_011072.1 478575 478874 D IS1381 transposase OrfB 478575..478874 Streptococcus pneumoniae G54 6479329 YP_002037201.1 CDS blpM NC_011072.1 479024 479278 D De Saizieu, A.; 2000 J.Bact 182:4696-4703; identified by match to protein family HMM TIGR01847; bacteriocin BlpM 479024..479278 Streptococcus pneumoniae G54 6478902 YP_002037202.1 CDS blpN NC_011072.1 479294 479497 D De Saizieu, A.; 2000 J.Bact 182:4696-4703; bacteriocin BlpN 479294..479497 Streptococcus pneumoniae G54 6479800 YP_002037203.1 CDS SPG_0488 NC_011072.1 479516 479725 D bacteriocin Blp 479516..479725 Streptococcus pneumoniae G54 6480154 YP_002037204.1 CDS blpO NC_011072.1 479741 479890 D De Saizieu, A.; 2000 J.Bact 182:4696-4703; identified by match to protein family HMM TIGR01847; bacteriocin BlpO 479741..479890 Streptococcus pneumoniae G54 6479433 YP_002037205.1 CDS SPG_0490 NC_011072.1 479872 479991 D hypothetical protein 479872..479991 Streptococcus pneumoniae G54 6480717 YP_002037206.1 CDS SPG_0491 NC_011072.1 479994 480113 D hypothetical protein 479994..480113 Streptococcus pneumoniae G54 6479518 YP_002037207.1 CDS blpX NC_011072.1 480899 481282 D De Saizieu, A.; 2000 J.Bact 182:4696-4703; immunity protein BlpX 480899..481282 Streptococcus pneumoniae G54 6479491 YP_002037208.1 CDS SPG_0493 NC_011072.1 481334 482023 D De Saizieu, A.; 2000 J.Bact 182:4696-4703; identified by match to protein family HMM PF02517; immunity protein BlpY 481334..482023 Streptococcus pneumoniae G54 6480398 YP_002037209.1 CDS blpZ NC_011072.1 482065 482313 D De Saizieu, A.; 2000 J.Bact 182:4696-4703; BlpZ protein 482065..482313 Streptococcus pneumoniae G54 6479143 YP_002037210.1 CDS SPG_0495 NC_011072.1 482343 482954 D identified by match to protein family HMM PF02517; CAAX amino terminal protease family 482343..482954 Streptococcus pneumoniae G54 6480824 YP_002037211.1 CDS SPG_0496 NC_011072.1 483115 483909 D identified by match to protein family HMM PF01636; phosphotransferase enzyme family protein 483115..483909 Streptococcus pneumoniae G54 6480603 YP_002037212.1 CDS trmB NC_011072.1 483906 484541 D tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 483906..484541 Streptococcus pneumoniae G54 6479439 YP_002037213.1 CDS SPG_0498 NC_011072.1 484667 485146 D in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 484667..485146 Streptococcus pneumoniae G54 6480656 YP_002037214.1 CDS nusA NC_011072.1 485190 486326 D modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 485190..486326 Streptococcus pneumoniae G54 6479707 YP_002037215.1 CDS SPG_0500 NC_011072.1 486348 486641 D identified by match to protein family HMM PF04296; hypothetical protein 486348..486641 Streptococcus pneumoniae G54 6479620 YP_002037216.1 CDS SPG_0501 NC_011072.1 486634 486933 D identified by match to protein family HMM PF01248; hypothetical protein 486634..486933 Streptococcus pneumoniae G54 6479201 YP_002037217.1 CDS infB NC_011072.1 486950 489742 D Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 486950..489742 Streptococcus pneumoniae G54 6478715 YP_002037218.1 CDS rbfA NC_011072.1 489993 490343 D associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 489993..490343 Streptococcus pneumoniae G54 6479582 YP_002037219.1 CDS SPG_0504 NC_011072.1 490631 491977 D identified by match to protein family HMM PF01609; IS1380-Spn1 transposase 490631..491977 Streptococcus pneumoniae G54 6478916 YP_002037220.1 CDS SPG_0505 NC_011072.1 492330 493109 D hypothetical protein 492330..493109 Streptococcus pneumoniae G54 6480772 YP_002037221.1 CDS SPG_0506 NC_011072.1 493180 493293 D hypothetical protein 493180..493293 Streptococcus pneumoniae G54 6478848 YP_002037222.1 CDS SPG_0507 NC_011072.1 493290 493442 D identified by glimmer; putative; hypothetical protein 493290..493442 Streptococcus pneumoniae G54 6479896 YP_002037223.1 CDS SPG_0508 NC_011072.1 493755 493988 D identified by match to protein family HMM PF08984; hypothetical protein 493755..493988 Streptococcus pneumoniae G54 6479560 YP_002037224.1 CDS SPG_0509 NC_011072.1 493988 495322 D identified by match to protein family HMM PF01814; match to protein family HMM PF04282; hypothetical protein 493988..495322 Streptococcus pneumoniae G54 6480321 YP_002037225.1 CDS SPG_0510 NC_011072.1 495332 495586 D identified by glimmer; putative; hypothetical protein 495332..495586 Streptococcus pneumoniae G54 6480222 YP_002037226.1 CDS SPG_0511 NC_011072.1 495682 495855 D hypothetical protein 495682..495855 Streptococcus pneumoniae G54 6478795 YP_002037227.1 CDS SPG_0512 NC_011072.1 495915 496076 D hypothetical protein 495915..496076 Streptococcus pneumoniae G54 6479022 YP_002037228.1 CDS SPG_0513 NC_011072.1 496620 496937 D identified by glimmer; putative; hypothetical protein 496620..496937 Streptococcus pneumoniae G54 6478660 YP_002037229.1 CDS SPG_0514 NC_011072.1 496924 497484 D identified by match to protein family HMM PF00583; GNAT family acetyltransferase 496924..497484 Streptococcus pneumoniae G54 6479714 YP_002037230.1 CDS SPG_0515 NC_011072.1 497484 498062 D identified by glimmer; putative; hypothetical protein 497484..498062 Streptococcus pneumoniae G54 6480621 YP_002037231.1 CDS valS NC_011072.1 498055 500706 D valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 498055..500706 Streptococcus pneumoniae G54 6479302 YP_002037232.1 CDS SPG_0517 NC_011072.1 500776 501072 D contains potential frameshift; hypothetical protein 500776..501072 Streptococcus pneumoniae G54 6479460 YP_002037233.1 CDS SPG_0518 NC_011072.1 501171 501530 D contains potential frameshift; hypothetical protein 501171..501530 Streptococcus pneumoniae G54 6479151 YP_002037234.1 CDS SPG_0519 NC_011072.1 501809 502612 D identified by match to protein family HMM PF02661; cell filamentation protein Fic-related protein 501809..502612 Streptococcus pneumoniae G54 6480114 YP_002037235.1 CDS SPG_0520 NC_011072.1 502728 502946 R IS3-Spn1 transposase complement(502728..502946) Streptococcus pneumoniae G54 6478843 YP_002037236.1 CDS SPG_0521 NC_011072.1 503224 503553 R IS3-Spn1 transposase complement(503224..503553) Streptococcus pneumoniae G54 6480509 YP_002037237.1 CDS SPG_0522 NC_011072.1 503553 503720 R degenarate transposase complement(503553..503720) Streptococcus pneumoniae G54 6480544 YP_002037238.1 CDS SPG_0523 NC_011072.1 503857 504069 R IS3-Spn1 transposase complement(503857..504069) Streptococcus pneumoniae G54 6479449 YP_002037239.1 CDS licT NC_011072.1 504611 505450 D identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator LicT 504611..505450 Streptococcus pneumoniae G54 6479273 YP_002037240.1 CDS SPG_0525 NC_011072.1 505468 507306 D identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00830; match to protein family HMM TIGR01995; PTS system transporter subunit IIBCA 505468..507306 Streptococcus pneumoniae G54 6479078 YP_002037241.1 CDS SPG_0526 NC_011072.1 507319 508734 D identified by match to protein family HMM PF00232; beta-glucosidase 507319..508734 Streptococcus pneumoniae G54 6480694 YP_002037242.1 CDS pheS NC_011072.1 509284 510372 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 509284..510372 Streptococcus pneumoniae G54 6479187 YP_002037243.1 CDS SPG_0528 NC_011072.1 510372 510869 D identified by match to protein family HMM PF00583; GNAT family acetyltransferase 510372..510869 Streptococcus pneumoniae G54 6480111 YP_002037244.1 CDS pheT NC_011072.1 510946 513351 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 510946..513351 Streptococcus pneumoniae G54 6480019 YP_002037245.1 CDS SPG_0530 NC_011072.1 513419 514426 R identified by match to protein family HMM PF03372; hypothetical protein complement(513419..514426) Streptococcus pneumoniae G54 6479530 YP_002037246.1 CDS SPG_0531 NC_011072.1 514582 514806 D IS1239, transposase 514582..514806 Streptococcus pneumoniae G54 6479998 YP_002037247.1 CDS SPG_0532 NC_011072.1 514869 514988 D transposase 514869..514988 Streptococcus pneumoniae G54 6480487 YP_002037248.1 CDS SPG_0533 NC_011072.1 515110 515376 D contains potential frameshift; identified by match to protein family HMM PF01381; hypothetical protein 515110..515376 Streptococcus pneumoniae G54 6480439 YP_002037249.1 CDS SPG_0534 NC_011072.1 515637 517886 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 515637..517886 Streptococcus pneumoniae G54 6478777 YP_002037250.1 CDS metF NC_011072.1 517950 518816 D identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; 5,10-methylenetetrahydrofolate reductase 517950..518816 Streptococcus pneumoniae G54 6479221 YP_002037251.1 CDS SPG_0536 NC_011072.1 519501 521714 D identified by match to protein family HMM PF00013; match to protein family HMM PF00575; match to protein family HMM PF01138; match to protein family HMM PF03725; match to protein family HMM PF03726; polynucleotide phosphorylase/polyadenylase 519501..521714 Streptococcus pneumoniae G54 6479793 YP_002037252.1 CDS cysE NC_011072.1 521730 522347 D identified by match to protein family HMM TIGR01172; serine O-acetyltransferase 521730..522347 Streptococcus pneumoniae G54 6479933 YP_002037253.1 CDS SPG_0538 NC_011072.1 522359 523243 D identified by match to protein family HMM PF00583; GNAT family acetyltransferase 522359..523243 Streptococcus pneumoniae G54 6478811 YP_002037254.1 CDS cysS NC_011072.1 523325 524668 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 523325..524668 Streptococcus pneumoniae G54 6479543 YP_002037255.1 CDS SPG_0540 NC_011072.1 524661 525047 D identified by match to protein family HMM PF00636; hypothetical protein 524661..525047 Streptococcus pneumoniae G54 6479787 YP_002037256.1 CDS SPG_0541 NC_011072.1 525051 525935 D identified by glimmer; putative; hypothetical protein 525051..525935 Streptococcus pneumoniae G54 6478789 YP_002037257.1 CDS SPG_0542 NC_011072.1 526072 526671 D hypothetical protein 526072..526671 Streptococcus pneumoniae G54 6479558 YP_002037258.1 CDS SPG_0543 NC_011072.1 526817 526987 D putative group II intron protein 526817..526987 Streptococcus pneumoniae G54 6478708 YP_002037259.1 CDS SPG_0544 NC_011072.1 527340 528617 D identified by match to protein family HMM PF02687; ABC transporter permease 527340..528617 Streptococcus pneumoniae G54 6480243 YP_002037260.1 CDS SPG_0545 NC_011072.1 528630 529277 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 528630..529277 Streptococcus pneumoniae G54 6479524 YP_002037261.1 CDS SPG_0546 NC_011072.1 529329 530708 D identified by match to protein family HMM PF02687; ABC transporter permease 529329..530708 Streptococcus pneumoniae G54 6479428 YP_002037262.1 CDS vncR NC_011072.1 531020 531676 D Haas W J Bacteriol. 2004 186(24):8463-71.; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; VncR response regulator TCS10 531020..531676 Streptococcus pneumoniae G54 6479506 YP_002037263.1 CDS vncS NC_011072.1 531673 533001 D Haas W J Bacteriol. 2004 186(24):8463-71.; identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; VncS histidine kinase TCS10 531673..533001 Streptococcus pneumoniae G54 6479569 YP_002037264.1 CDS fba NC_011072.1 533142 534023 D catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 533142..534023 Streptococcus pneumoniae G54 6480256 YP_002037265.1 CDS SPG_0550 NC_011072.1 534345 535535 R identified by match to protein family HMM PF00175; match to protein family HMM PF00970; match to protein family HMM PF01794; oxidoreductase complement(534345..535535) Streptococcus pneumoniae G54 6480407 YP_002037266.1 CDS SPG_0551 NC_011072.1 535830 536489 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; ABC transporter permease complement(535830..536489) Streptococcus pneumoniae G54 6480173 YP_002037267.1 CDS SPG_0552 NC_011072.1 536499 537176 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; ABC transporter permease complement(536499..537176) Streptococcus pneumoniae G54 6480128 YP_002037268.1 CDS SPG_0553 NC_011072.1 537189 537983 R identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein complement(537189..537983) Streptococcus pneumoniae G54 6480279 YP_002037269.1 CDS SPG_0554 NC_011072.1 537994 538752 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(537994..538752) Streptococcus pneumoniae G54 6479699 YP_002037270.1 CDS recJ NC_011072.1 539029 541251 D identified by match to protein family HMM PF01368; match to protein family HMM PF02272; match to protein family HMM TIGR00644; single-stranded-DNA-specific exonuclease RecJ 539029..541251 Streptococcus pneumoniae G54 6479624 YP_002037271.1 CDS SPG_0556 NC_011072.1 541426 543087 D identified by match to protein family HMM PF00753; match to protein family HMM PF07521; hypothetical protein 541426..543087 Streptococcus pneumoniae G54 6478806 YP_002037272.1 CDS SPG_0557 NC_011072.1 543156 543935 D identified by match to protein family HMM PF00756; esterase 543156..543935 Streptococcus pneumoniae G54 6479287 YP_002037273.1 CDS SPG_0558 NC_011072.1 544047 545267 D identified by match to protein family HMM PF02388; serine/alanine-adding enzyme MurM 544047..545267 Streptococcus pneumoniae G54 6479474 YP_002037274.1 CDS SPG_0559 NC_011072.1 545272 546504 D identified by match to protein family HMM PF02388; alanine adding enzyme 545272..546504 Streptococcus pneumoniae G54 6478716 YP_002037275.1 CDS SPG_0560 NC_011072.1 546583 547284 D identified by match to protein family HMM PF00413; hypothetical protein 546583..547284 Streptococcus pneumoniae G54 6479960 YP_002037276.1 CDS uvrC NC_011072.1 547324 549171 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 547324..549171 Streptococcus pneumoniae G54 6480458 YP_002037277.1 CDS SPG_0562 NC_011072.1 549221 549994 D hypothetical protein 549221..549994 Streptococcus pneumoniae G54 6479285 YP_002037278.1 CDS SPG_0563 NC_011072.1 550176 550976 R identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein complement(550176..550976) Streptococcus pneumoniae G54 6479493 YP_002037279.1 CDS SPG_0564 NC_011072.1 551147 551302 D contains potential frameshift; nitroreductase 551147..551302 Streptococcus pneumoniae G54 6480261 YP_002037280.1 CDS SPG_0565 NC_011072.1 551325 551753 D contains potential frameshift; identified by match to protein family HMM PF00881; nitroreductase 551325..551753 Streptococcus pneumoniae G54 6480583 YP_002037281.1 CDS SPG_0566 NC_011072.1 551766 553166 D divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 551766..553166 Streptococcus pneumoniae G54 6478687 YP_002037282.1 CDS SPG_0567 NC_011072.1 553220 553798 D identified by match to protein family HMM PF03167; hypothetical protein 553220..553798 Streptococcus pneumoniae G54 6479450 YP_002037283.1 CDS SPG_0568 NC_011072.1 553958 554110 D hypothetical protein 553958..554110 Streptococcus pneumoniae G54 6479025 YP_002037284.1 CDS SPG_0569 NC_011072.1 554111 554245 D hypothetical protein 554111..554245 Streptococcus pneumoniae G54 6478952 YP_002037285.1 CDS SPG_0570 NC_011072.1 554416 555741 D identified by match to protein family HMM PF05525; match to protein family HMM TIGR00796; branched-chain amino acid transport protein 554416..555741 Streptococcus pneumoniae G54 6479798 YP_002037286.1 CDS SPG_0571 NC_011072.1 555839 556876 D identified by match to protein family HMM PF05343; hypothetical protein 555839..556876 Streptococcus pneumoniae G54 6479136 YP_002037287.1 CDS SPG_0572 NC_011072.1 556878 557339 D identified by match to protein family HMM PF01230; histidine triad domain-containing protein 556878..557339 Streptococcus pneumoniae G54 6479084 YP_002037288.1 CDS SPG_0573 NC_011072.1 557365 558081 D identified by match to protein family HMM PF02557; D-alanyl-D-alanine carboxypeptidase 557365..558081 Streptococcus pneumoniae G54 6480100 YP_002037289.1 CDS rplK NC_011072.1 558390 558815 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 558390..558815 Streptococcus pneumoniae G54 6479480 YP_002037290.1 CDS rplA NC_011072.1 559023 559712 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 559023..559712 Streptococcus pneumoniae G54 6479390 YP_002037291.1 CDS SPG_0576 NC_011072.1 559801 560328 R IS1167 transposase complement(559801..560328) Streptococcus pneumoniae G54 6480704 YP_002037292.1 CDS SPG_0577 NC_011072.1 560609 561127 R IS1167 transposase complement(560609..561127) Streptococcus pneumoniae G54 6480289 YP_002037293.1 CDS SPG_0578 NC_011072.1 562049 562267 D hypothetical protein 562049..562267 Streptococcus pneumoniae G54 6479213 YP_002037294.1 CDS SPG_0579 NC_011072.1 563311 564303 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 563311..564303 Streptococcus pneumoniae G54 6480543 YP_002037295.1 CDS SPG_0580 NC_011072.1 564305 565123 D identified by match to protein family HMM PF06182; ABC transporter permease 564305..565123 Streptococcus pneumoniae G54 6480584 YP_002037296.1 CDS SPG_0581 NC_011072.1 565125 565910 D identified by match to protein family HMM PF06182; ABC transporter permease 565125..565910 Streptococcus pneumoniae G54 6480038 YP_002037297.1 CDS SPG_0582 NC_011072.1 565949 566227 D identified by glimmer; putative; hypothetical protein 565949..566227 Streptococcus pneumoniae G54 6478747 YP_002037298.1 CDS SPG_0583 NC_011072.1 566212 566409 D hypothetical protein 566212..566409 Streptococcus pneumoniae G54 6479703 YP_002037299.1 CDS prtA NC_011072.1 567097 573528 D identified by match to protein family HMM PF00082; match to protein family HMM PF00746; match to protein family HMM PF02225; match to protein family HMM PF05922; match to protein family HMM PF06280; match to protein family HMM TIGR01167; serine protease 567097..573528 Streptococcus pneumoniae G54 6478885 YP_002037300.1 CDS SPG_0585 NC_011072.1 574154 574630 D identified by match to protein family HMM PF00359; PTS system transporter subunit IIA 574154..574630 Streptococcus pneumoniae G54 6479203 YP_002037301.1 CDS SPG_0586 NC_011072.1 574668 574973 D PTS system transporter subunit IIB 574668..574973 Streptococcus pneumoniae G54 6479252 YP_002037302.1 CDS SPG_0587 NC_011072.1 575021 576496 D identified by match to protein family HMM PF03611; PTS system transporter subunit IIC 575021..576496 Streptococcus pneumoniae G54 6479541 YP_002037303.1 CDS SPG_0588 NC_011072.1 576846 583547 D identified by match to protein family HMM PF00703; match to protein family HMM PF00746; match to protein family HMM PF02836; match to protein family HMM PF02837; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07532; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-galactosidase 576846..583547 Streptococcus pneumoniae G54 6480768 YP_002037304.1 CDS SPG_0589 NC_011072.1 583804 584025 R transposase complement(583804..584025) Streptococcus pneumoniae G54 6479262 YP_002037305.1 CDS SPG_0590 NC_011072.1 583994 584407 R transposase complement(583994..584407) Streptococcus pneumoniae G54 6480705 YP_002037306.1 CDS SPG_0591 NC_011072.1 584407 584652 R transposase complement(584407..584652) Streptococcus pneumoniae G54 6480276 YP_002037307.1 CDS SPG_0592 NC_011072.1 584863 585222 R identified by glimmer; putative; hypothetical protein complement(584863..585222) Streptococcus pneumoniae G54 6480331 YP_002037308.1 CDS SPG_0593 NC_011072.1 585314 585766 D hypothetical protein 585314..585766 Streptococcus pneumoniae G54 6479977 YP_002037309.1 CDS SPG_0594 NC_011072.1 585824 586270 D identified by glimmer; putative; hypothetical protein 585824..586270 Streptococcus pneumoniae G54 6479475 YP_002037310.1 CDS SPG_0595 NC_011072.1 586254 586811 D identified by match to protein family HMM PF06962; hypothetical protein 586254..586811 Streptococcus pneumoniae G54 6479636 YP_002037311.1 CDS SPG_0596 NC_011072.1 586804 587058 D hypothetical protein 586804..587058 Streptococcus pneumoniae G54 6480553 YP_002037312.1 CDS SPG_0597 NC_011072.1 587070 589124 D identified by match to protein family HMM PF00999; monovalent cation:proton antiporter-2 (CPA2) family transporter 587070..589124 Streptococcus pneumoniae G54 6478718 YP_002037313.1 CDS SPG_0598 NC_011072.1 589303 590163 D identified by match to protein family HMM PF03631; ribonuclease BN 589303..590163 Streptococcus pneumoniae G54 6478890 YP_002037314.1 CDS SPG_0599 NC_011072.1 590374 591084 D identified by match to protein family HMM PF02683; cytochrome c-type biogenesis protein CcdA 590374..591084 Streptococcus pneumoniae G54 6480122 YP_002037315.1 CDS SPG_0600 NC_011072.1 591104 591670 D identified by match to protein family HMM PF00578; match to protein family HMM PF08534; thioredoxin family protein 591104..591670 Streptococcus pneumoniae G54 6480440 YP_002037316.1 CDS SPG_0601 NC_011072.1 591681 592793 D identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; peptide methionine sulfoxide reductase MsrA/msrB 591681..592793 Streptococcus pneumoniae G54 6479599 YP_002037317.1 CDS SPG_0602 NC_011072.1 593061 593798 D identified by match to protein family HMM PF00072; match to protein family HMM PF00165; response regulator 593061..593798 Streptococcus pneumoniae G54 6478846 YP_002037318.1 CDS SPG_0603 NC_011072.1 593795 595486 D identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF02743; match to protein family HMM PF06580; histidine kinase 593795..595486 Streptococcus pneumoniae G54 6479886 YP_002037319.1 CDS SPG_0604 NC_011072.1 595602 596165 D identified by match to protein family HMM PF04260; match to protein family HMM TIGR01440; hypothetical protein 595602..596165 Streptococcus pneumoniae G54 6480822 YP_002037320.1 CDS zmpB NC_011072.1 596187 601799 D identified by match to protein family HMM PF00746; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM TIGR01167; zinc metalloprotease ZmpB 596187..601799 Streptococcus pneumoniae G54 6479105 YP_002037321.1 CDS SPG_0606 NC_011072.1 601873 603594 D identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553; para-aminobenzoate synthases component I 601873..603594 Streptococcus pneumoniae G54 6479873 YP_002037322.1 CDS SPG_0607 NC_011072.1 603595 604212 D hypothetical protein 603595..604212 Streptococcus pneumoniae G54 6479869 YP_002037323.1 CDS SPG_0608 NC_011072.1 604262 605188 D contains potential frameshift; identified by match to protein family HMM PF01473; match to protein family HMM PF05901; choline binding protein 604262..605188 Streptococcus pneumoniae G54 6478759 YP_002037324.1 CDS gki NC_011072.1 605369 606346 D identified by match to protein family HMM PF00480; match to protein family HMM TIGR00744; glucokinase 605369..606346 Streptococcus pneumoniae G54 6479613 YP_002037325.1 CDS thyA NC_011072.1 606443 607282 D ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 606443..607282 Streptococcus pneumoniae G54 6480095 YP_002037326.1 CDS SPG_0611 NC_011072.1 607330 607500 R hypothetical protein complement(607330..607500) Streptococcus pneumoniae G54 6479695 YP_002037327.1 CDS miaA NC_011072.1 607621 608505 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 607621..608505 Streptococcus pneumoniae G54 6478678 YP_002037328.1 CDS SPG_0613 NC_011072.1 608498 609736 D identified by match to protein family HMM PF01926; match to protein family HMM TIGR00231; match to protein family HMM TIGR03156; GTP-binding proten HflX 608498..609736 Streptococcus pneumoniae G54 6480695 YP_002037329.1 CDS SPG_0614 NC_011072.1 609729 610352 D identified by glimmer; putative; hypothetical protein 609729..610352 Streptococcus pneumoniae G54 6480221 YP_002037330.1 CDS rnz NC_011072.1 610367 611296 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 610367..611296 Streptococcus pneumoniae G54 6479177 YP_002037331.1 CDS SPG_0616 NC_011072.1 611317 612072 D identified by match to protein family HMM PF00106; match to protein family HMM PF08659; short chain dehydrogenase/reductase family oxidoreductase 611317..612072 Streptococcus pneumoniae G54 6479818 YP_002037332.1 CDS SPG_0617 NC_011072.1 612126 613094 R identified by match to protein family HMM PF00126; transcriptional regulator complement(612126..613094) Streptococcus pneumoniae G54 6478883 YP_002037333.1 CDS SPG_0618 NC_011072.1 613098 613367 D identified by match to protein family HMM PF06014; hypothetical protein 613098..613367 Streptococcus pneumoniae G54 6479054 YP_002037334.1 CDS SPG_0619 NC_011072.1 613367 613747 D identified by match to protein family HMM PF00581; rhodanese-like domain 613367..613747 Streptococcus pneumoniae G54 6480141 YP_002037335.1 CDS SPG_0620 NC_011072.1 613836 614063 D hypothetical protein 613836..614063 Streptococcus pneumoniae G54 6479068 YP_002037336.1 CDS SPG_0621 NC_011072.1 614103 614828 R identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A complement(614103..614828) Streptococcus pneumoniae G54 6480325 YP_002037337.1 CDS SPG_0622 NC_011072.1 614990 615796 D contains potential frameshift; identified by match to protein family HMM PF00009; match to protein family HMM TIGR00231; elongation factor Tu family protein 614990..615796 Streptococcus pneumoniae G54 6479250 YP_002037338.1 CDS SPG_0623 NC_011072.1 615753 616832 D contains potential frameshift; identified by match to protein family HMM PF00679; elongation factor Tu family protein 615753..616832 Streptococcus pneumoniae G54 6479086 YP_002037339.1 CDS SPG_0624 NC_011072.1 616852 617106 D hypothetical protein 616852..617106 Streptococcus pneumoniae G54 6479330 YP_002037340.1 CDS SPG_0625 NC_011072.1 617469 617768 D identified by match to protein family HMM TIGR01653; hypothetical protein 617469..617768 Streptococcus pneumoniae G54 6480713 YP_002037341.1 CDS SPG_0626 NC_011072.1 617839 619860 D identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; hypothetical protein 617839..619860 Streptococcus pneumoniae G54 6479056 YP_002037342.1 CDS SPG_0627 NC_011072.1 619862 620503 D identified by match to protein family HMM PF00005; match to protein family HMM TIGR03608; ABC transporter ATP-binding protein 619862..620503 Streptococcus pneumoniae G54 6480210 YP_002037343.1 CDS murD NC_011072.1 620607 621959 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 620607..621959 Streptococcus pneumoniae G54 6479863 YP_002037344.1 CDS murG NC_011072.1 621963 623021 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 621963..623021 Streptococcus pneumoniae G54 6480790 YP_002037345.1 CDS SPG_0630 NC_011072.1 623031 624230 D identified by match to protein family HMM PF03799; match to protein family HMM PF08478; cell division protein DivIB 623031..624230 Streptococcus pneumoniae G54 6479268 YP_002037346.1 CDS pyrF NC_011072.1 624463 625164 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 624463..625164 Streptococcus pneumoniae G54 6480766 YP_002037347.1 CDS pyrE NC_011072.1 625198 625830 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 625198..625830 Streptococcus pneumoniae G54 6479041 YP_002037348.1 CDS SPG_0633 NC_011072.1 626063 626413 D contains potential frameshift; hypothetical protein 626063..626413 Streptococcus pneumoniae G54 6480163 YP_002037349.1 CDS SPG_0634 NC_011072.1 626509 627273 D identified by glimmer; putative; hypothetical protein 626509..627273 Streptococcus pneumoniae G54 6480610 YP_002037350.1 CDS SPG_0635 NC_011072.1 627273 628025 D identified by glimmer; putative; hypothetical protein 627273..628025 Streptococcus pneumoniae G54 6480131 YP_002037351.1 CDS SPG_0636 NC_011072.1 628029 628733 D hypothetical protein 628029..628733 Streptococcus pneumoniae G54 6479785 YP_002037352.1 CDS SPG_0637 NC_011072.1 628730 629377 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 628730..629377 Streptococcus pneumoniae G54 6480536 YP_002037353.1 CDS SPG_0638 NC_011072.1 629457 630005 R contains potential frameshift; ABC transporter substrate binding protein complement(629457..630005) Streptococcus pneumoniae G54 6478772 YP_002037354.1 CDS SPG_0639 NC_011072.1 630080 630193 R contains potential frameshift; ABC transporter substrate binding protein complement(630080..630193) Streptococcus pneumoniae G54 6479107 YP_002037355.1 CDS SPG_0640 NC_011072.1 630171 630323 R contains potential frameshift; ABC transporter substrate binding protein complement(630171..630323) Streptococcus pneumoniae G54 6479071 YP_002037356.1 CDS SPG_0641 NC_011072.1 630335 630730 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(630335..630730) Streptococcus pneumoniae G54 6478677 YP_002037357.1 CDS SPG_0642 NC_011072.1 630830 631093 R ABC transporter ATP-binding protein complement(630830..631093) Streptococcus pneumoniae G54 6480025 YP_002037358.1 CDS SPG_0643 NC_011072.1 631094 631381 R ABC transporter permease complement(631094..631381) Streptococcus pneumoniae G54 6478859 YP_002037359.1 CDS SPG_0644 NC_011072.1 631391 631771 R identified by match to protein family HMM TIGR01726; ABC transporter permease complement(631391..631771) Streptococcus pneumoniae G54 6480332 YP_002037360.1 CDS SPG_0645 NC_011072.1 631731 632411 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; ABC transporter permease complement(631731..632411) Streptococcus pneumoniae G54 6480269 YP_002037361.1 CDS SPG_0646 NC_011072.1 632626 632772 D hypothetical protein 632626..632772 Streptococcus pneumoniae G54 6479008 YP_002037362.1 CDS lysS NC_011072.1 632900 634390 D class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 632900..634390 Streptococcus pneumoniae G54 6479058 YP_002037363.1 CDS SPG_0648 NC_011072.1 635014 636150 D identified by match to protein family HMM PF01070; match to protein family HMM TIGR02708; L-lactate oxidase 635014..636150 Streptococcus pneumoniae G54 6479888 YP_002037364.1 CDS SPG_0649 NC_011072.1 636707 637375 D identified by match to protein family HMM PF03070; TENA/THI-4 family transcriptional regulator 636707..637375 Streptococcus pneumoniae G54 6479377 YP_002037365.1 CDS thiM NC_011072.1 637702 638484 D catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 637702..638484 Streptococcus pneumoniae G54 6479907 YP_002037366.1 CDS thiE NC_011072.1 638486 639115 D identified by match to protein family HMM PF02581; match to protein family HMM TIGR00693; thiamine-phosphate pyrophosphorylase 638486..639115 Streptococcus pneumoniae G54 6479686 YP_002037367.1 CDS SPG_0652 NC_011072.1 639674 640234 D ABC transporter permease 639674..640234 Streptococcus pneumoniae G54 6479407 YP_002037368.1 CDS SPG_0653 NC_011072.1 640235 641620 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 640235..641620 Streptococcus pneumoniae G54 6479255 YP_002037369.1 CDS SPG_0654 NC_011072.1 641622 642272 D hypothetical protein 641622..642272 Streptococcus pneumoniae G54 6480719 YP_002037370.1 CDS SPG_0655 NC_011072.1 642283 642975 D identified by match to protein family HMM PF03070; transcriptional activator TenA 642283..642975 Streptococcus pneumoniae G54 6479145 YP_002037371.1 CDS thiW NC_011072.1 642980 643504 D identified by match to protein family HMM TIGR02359; ThiW protein 642980..643504 Streptococcus pneumoniae G54 6480566 YP_002037372.1 CDS SPG_0657 NC_011072.1 643504 644307 D identified by match to protein family HMM PF02110; hydroxyethylthiazole kinase 643504..644307 Streptococcus pneumoniae G54 6480663 YP_002037373.1 CDS thiE NC_011072.1 644300 644932 D Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 644300..644932 Streptococcus pneumoniae G54 6479461 YP_002037374.1 CDS thiD NC_011072.1 645141 645932 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(645141..645932) Streptococcus pneumoniae G54 6478646 YP_002037375.1 CDS SPG_0660 NC_011072.1 646298 646693 D identified by match to protein family HMM PF03965; match to protein family HMM TIGR02698; transcriptional regulator 646298..646693 Streptococcus pneumoniae G54 6480310 YP_002037376.1 CDS SPG_0661 NC_011072.1 646704 647075 D hypothetical protein 646704..647075 Streptococcus pneumoniae G54 6479756 YP_002037377.1 CDS SPG_0662 NC_011072.1 647085 649328 D identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM PF08282; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525; E1-E2 family cation-transporting ATPase 647085..649328 Streptococcus pneumoniae G54 6480753 YP_002037378.1 CDS spxB NC_011072.1 649535 651310 D identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR02720; pyruvate oxidase 649535..651310 Streptococcus pneumoniae G54 6479320 YP_002037379.1 CDS SPG_0664 NC_011072.1 651421 651768 D identified by match to protein family HMM PF00903; hypothetical protein 651421..651768 Streptococcus pneumoniae G54 6479536 YP_002037380.1 CDS SPG_0665 NC_011072.1 651980 652393 R IS630-SpnII transposase complement(651980..652393) Streptococcus pneumoniae G54 6478831 YP_002037381.1 CDS SPG_0666 NC_011072.1 652425 652691 R IS630-SpnII transposase complement(652425..652691) Streptococcus pneumoniae G54 6478691 YP_002037382.1 CDS SPG_0667 NC_011072.1 653206 653490 D contains potential frameshift; identified by glimmer; putative; hypothetical protein 653206..653490 Streptococcus pneumoniae G54 6480384 YP_002037383.1 CDS SPG_0668 NC_011072.1 653622 654566 D identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218; mannose-6-phosphate isomerase 653622..654566 Streptococcus pneumoniae G54 6480018 YP_002037384.1 CDS SPG_0669 NC_011072.1 654587 656065 R identified by match to protein family HMM PF00209; sodium-dependent transporter complement(654587..656065) Streptococcus pneumoniae G54 6479806 YP_002037385.1 CDS SPG_0670 NC_011072.1 656170 656919 D identified by match to protein family HMM PF00376; match to protein family HMM PF07739; match to protein family HMM PF09278; MerR family transcriptional regulator 656170..656919 Streptococcus pneumoniae G54 6478914 YP_002037386.1 CDS SPG_0671 NC_011072.1 656939 657394 R identified by match to protein family HMM PF00293; MutT/nudix family protein complement(656939..657394) Streptococcus pneumoniae G54 6480081 YP_002037387.1 CDS SPG_0672 NC_011072.1 657414 658589 R identified by match to protein family HMM PF03486; match to protein family HMM TIGR00275; hypothetical protein complement(657414..658589) Streptococcus pneumoniae G54 6480420 YP_002037388.1 CDS SPG_0673 NC_011072.1 658648 659493 R identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; hypothetical protein complement(658648..659493) Streptococcus pneumoniae G54 6479142 YP_002037389.1 CDS SPG_0674 NC_011072.1 659618 660175 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 659618..660175 Streptococcus pneumoniae G54 6480259 YP_002037390.1 CDS SPG_0675 NC_011072.1 660194 660661 D identified by match to protein family HMM PF00383; cytidine and deoxycytidylate deaminase family protein 660194..660661 Streptococcus pneumoniae G54 6479422 YP_002037391.1 CDS upp NC_011072.1 660729 661379 D Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 660729..661379 Streptococcus pneumoniae G54 6478644 YP_002037392.1 CDS SPG_0677 NC_011072.1 661553 661996 D contains potential frameshift; identified by match to protein family HMM PF00574; ATP-dependent Clp protease proteolytic subunit 661553..661996 Streptococcus pneumoniae G54 6478913 YP_002037393.1 CDS SPG_0678 NC_011072.1 662013 662144 D contains potential frameshift; ATP-dependent Clp protease proteolytic subunit 662013..662144 Streptococcus pneumoniae G54 6480552 YP_002037394.1 CDS SPG_0679 NC_011072.1 662223 662471 D identified by glimmer; putative; hypothetical protein 662223..662471 Streptococcus pneumoniae G54 6479072 YP_002037395.1 CDS livJ NC_011072.1 662572 663732 D identified by match to protein family HMM PF01094; branched-chain amino acid ABC transporter periplasmic protein 662572..663732 Streptococcus pneumoniae G54 6479844 YP_002037396.1 CDS livH NC_011072.1 664000 664869 D identified by match to protein family HMM PF02653; branched-chain amino acid ABC transporter permease 664000..664869 Streptococcus pneumoniae G54 6478820 YP_002037397.1 CDS livM NC_011072.1 664873 665829 D identified by match to protein family HMM PF02653; branched-chain amino acid ABC transporter permease 664873..665829 Streptococcus pneumoniae G54 6480749 YP_002037398.1 CDS livG NC_011072.1 665829 666593 D identified by match to protein family HMM PF00005; branched-chain amino acid ABC transporter ATP-binding protein 665829..666593 Streptococcus pneumoniae G54 6480391 YP_002037399.1 CDS livF NC_011072.1 666593 667303 D identified by match to protein family HMM PF00005; branched-chain amino acid ABC transporter ATP-binding protein 666593..667303 Streptococcus pneumoniae G54 6479765 YP_002037400.1 CDS SPG_0685 NC_011072.1 667611 668267 D identified by match to protein family HMM PF00571; acetoin utilization protein AcuB 667611..668267 Streptococcus pneumoniae G54 6480443 YP_002037401.1 CDS prfB NC_011072.1 668481 669470 D recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 668481..669470 Streptococcus pneumoniae G54 6479498 YP_002037402.1 CDS ftsE NC_011072.1 669488 670180 D identified by match to protein family HMM PF00005; match to protein family HMM TIGR02673; cell division ATP-binding protein FtsE 669488..670180 Streptococcus pneumoniae G54 6479423 YP_002037403.1 CDS SPG_0688 NC_011072.1 670173 671099 D identified by match to protein family HMM PF02687; Cell division protein FtsX 670173..671099 Streptococcus pneumoniae G54 6479644 YP_002037404.1 CDS SPG_0689 NC_011072.1 671385 671897 D contains potential frameshift; PTS system transporter subunit IIBCA 671385..671897 Streptococcus pneumoniae G54 6479948 YP_002037405.1 CDS SPG_0690 NC_011072.1 672079 673566 D contains potential frameshift; identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; PTS system transporter subunit IIBCA 672079..673566 Streptococcus pneumoniae G54 6479079 YP_002037406.1 CDS SPG_0691 NC_011072.1 673618 673950 D contains potential frameshift; identified by glimmer; putative; hypothetical protein 673618..673950 Streptococcus pneumoniae G54 6479185 YP_002037407.1 CDS SPG_0692 NC_011072.1 673964 674434 D contains potential frameshift; hypothetical protein 673964..674434 Streptococcus pneumoniae G54 6480393 YP_002037408.1 CDS SPG_0693 NC_011072.1 674574 675917 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; ATP-dependent RNA helicase 674574..675917 Streptococcus pneumoniae G54 6479405 YP_002037409.1 CDS metK NC_011072.1 676294 677484 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 676294..677484 Streptococcus pneumoniae G54 6480305 YP_002037410.1 CDS SPG_0695 NC_011072.1 678037 678972 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 678037..678972 Streptococcus pneumoniae G54 6480573 YP_002037411.1 CDS holA NC_011072.1 679006 680043 D required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 679006..680043 Streptococcus pneumoniae G54 6479350 YP_002037412.1 CDS sodA NC_011072.1 680216 680821 D identified by match to protein family HMM PF00081; match to protein family HMM PF02777; manganese-dependent superoxide dismutase 680216..680821 Streptococcus pneumoniae G54 6478940 YP_002037413.1 CDS SPG_0698 NC_011072.1 680978 681508 D identified by glimmer; putative; hypothetical protein 680978..681508 Streptococcus pneumoniae G54 6478643 YP_002037414.1 CDS SPG_0699 NC_011072.1 681529 682614 D 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 681529..682614 Streptococcus pneumoniae G54 6479892 YP_002037415.1 CDS SPG_0700 NC_011072.1 682713 683096 D identified by match to protein family HMM PF04892; hypothetical protein 682713..683096 Streptococcus pneumoniae G54 6479099 YP_002037416.1 CDS SPG_0701 NC_011072.1 683098 684639 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 683098..684639 Streptococcus pneumoniae G54 6479415 YP_002037417.1 CDS SPG_0702 NC_011072.1 684696 685499 R identified by match to protein family HMM PF00160; peptidyl-prolyl cis-trans isomerase, cyclophilin-type complement(684696..685499) Streptococcus pneumoniae G54 6479698 YP_002037418.1 CDS SPG_0703 NC_011072.1 685613 685804 R hypothetical protein complement(685613..685804) Streptococcus pneumoniae G54 6479974 YP_002037419.1 CDS SPG_0704 NC_011072.1 686283 686483 R hypothetical protein complement(686283..686483) Streptococcus pneumoniae G54 6478725 YP_002037420.1 CDS rpsP NC_011072.1 686662 686934 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 686662..686934 Streptococcus pneumoniae G54 6480247 YP_002037421.1 CDS SPG_0706 NC_011072.1 686954 687193 D hypothetical protein 686954..687193 Streptococcus pneumoniae G54 6478818 YP_002037422.1 CDS SPG_0707 NC_011072.1 687770 688558 D identified by match to protein family HMM PF00561; hypothetical protein 687770..688558 Streptococcus pneumoniae G54 6478768 YP_002037423.1 CDS rimM NC_011072.1 688589 689107 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 688589..689107 Streptococcus pneumoniae G54 6479299 YP_002037424.1 CDS trmD NC_011072.1 689097 689816 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 689097..689816 Streptococcus pneumoniae G54 6480218 YP_002037425.1 CDS SPG_0710 NC_011072.1 689828 690166 D identified by glimmer; putative; hypothetical protein 689828..690166 Streptococcus pneumoniae G54 6480185 YP_002037426.1 CDS SPG_0711 NC_011072.1 690196 690516 R identified by glimmer; putative; hypothetical protein complement(690196..690516) Streptococcus pneumoniae G54 6479062 YP_002037427.1 CDS SPG_0712 NC_011072.1 690614 690829 D hypothetical protein 690614..690829 Streptococcus pneumoniae G54 6479224 YP_002037428.1 CDS bioY NC_011072.1 691034 691570 R identified by match to protein family HMM PF02632; biotin synthase complement(691034..691570) Streptococcus pneumoniae G54 6480779 YP_002037429.1 CDS gor NC_011072.1 691766 693112 R catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase complement(691766..693112) Streptococcus pneumoniae G54 6479997 YP_002037430.1 CDS SPG_0715 NC_011072.1 693398 694597 D identified by match to protein family HMM TIGR01730; RND family efflux transporter 693398..694597 Streptococcus pneumoniae G54 6479953 YP_002037431.1 CDS SPG_0716 NC_011072.1 694581 695282 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 694581..695282 Streptococcus pneumoniae G54 6480738 YP_002037432.1 CDS SPG_0717 NC_011072.1 695284 696543 D identified by match to protein family HMM PF02687; ABC transporter permease 695284..696543 Streptococcus pneumoniae G54 6480815 YP_002037433.1 CDS metG NC_011072.1 696667 698664 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 696667..698664 Streptococcus pneumoniae G54 6479856 YP_002037434.1 CDS SPG_0719 NC_011072.1 699085 699405 D identified by match to protein family HMM PF03551; PadR family transcriptional regulator 699085..699405 Streptococcus pneumoniae G54 6480392 YP_002037435.1 CDS SPG_0720 NC_011072.1 699409 700224 D hypothetical protein 699409..700224 Streptococcus pneumoniae G54 6479494 YP_002037436.1 CDS SPG_0721 NC_011072.1 700299 701225 D identified by match to protein family HMM PF00248; aldo/keto reductase family oxidoreductase 700299..701225 Streptococcus pneumoniae G54 6480787 YP_002037437.1 CDS SPG_0722 NC_011072.1 701321 701557 D hypothetical protein 701321..701557 Streptococcus pneumoniae G54 6480255 YP_002037438.1 CDS fabG NC_011072.1 701550 702248 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 701550..702248 Streptococcus pneumoniae G54 6479313 YP_002037439.1 CDS SPG_0724 NC_011072.1 702259 702759 D identified by match to protein family HMM PF00293; MutT/nudix family protein 702259..702759 Streptococcus pneumoniae G54 6479859 YP_002037440.1 CDS SPG_0725 NC_011072.1 702737 703606 D identified by match to protein family HMM PF02896; hypothetical protein 702737..703606 Streptococcus pneumoniae G54 6479950 YP_002037441.1 CDS SPG_0726 NC_011072.1 703581 704021 D identified by match to protein family HMM PF06171; hypothetical protein 703581..704021 Streptococcus pneumoniae G54 6478938 YP_002037442.1 CDS SPG_0727 NC_011072.1 704144 706690 D identified by match to protein family HMM PF01433; aminopeptidase N 704144..706690 Streptococcus pneumoniae G54 6479565 YP_002037443.1 CDS ciaR NC_011072.1 706799 707473 D Guenzi Mol Microbiol. 1994 12(3):505-15.; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; CiaR response regulator TCS05 706799..707473 Streptococcus pneumoniae G54 6479630 YP_002037444.1 CDS ciaH NC_011072.1 707463 708797 D Guenzi Mol Microbiol. 1994 12(3):505-15.; identified by match to protein family HMM PF00512; match to protein family HMM PF02518; CiaH histidine kinase TCS05 707463..708797 Streptococcus pneumoniae G54 6479194 YP_002037445.1 CDS SPG_0730 NC_011072.1 708831 709118 R hypothetical protein complement(708831..709118) Streptococcus pneumoniae G54 6479226 YP_002037446.1 CDS SPG_0731 NC_011072.1 709258 710187 D identified by glimmer; putative; hypothetical protein 709258..710187 Streptococcus pneumoniae G54 6480410 YP_002037447.1 CDS SPG_0732 NC_011072.1 710387 712837 D unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 710387..712837 Streptococcus pneumoniae G54 6478887 YP_002037448.1 CDS SPG_0733 NC_011072.1 712874 714097 D identified by match to protein family HMM PF01098; FtsW/RodA/SpoVE family cell cycle protein 712874..714097 Streptococcus pneumoniae G54 6478733 YP_002037449.1 CDS SPG_0734 NC_011072.1 714108 714662 D identified by match to protein family HMM PF01965; match to protein family HMM TIGR01383; 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein 714108..714662 Streptococcus pneumoniae G54 6480180 YP_002037450.1 CDS SPG_0735 NC_011072.1 714747 715310 D identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; haloacid dehalogenase-like hydrolase 714747..715310 Streptococcus pneumoniae G54 6480381 YP_002037451.1 CDS gyrB NC_011072.1 715325 717271 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 715325..717271 Streptococcus pneumoniae G54 6479188 YP_002037452.1 CDS ezrA NC_011072.1 717353 719080 D acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 717353..719080 Streptococcus pneumoniae G54 6479754 YP_002037453.1 CDS SPG_0738 NC_011072.1 719810 720133 R identified by match to protein family HMM PF05717; IS66-Spn1 transposase complement(719810..720133) Streptococcus pneumoniae G54 6479029 YP_002037454.1 CDS SPG_0739 NC_011072.1 720394 720693 R identified by match to protein family HMM PF08860; hypothetical protein complement(720394..720693) Streptococcus pneumoniae G54 6479586 YP_002037455.1 CDS SPG_0740 NC_011072.1 720858 721121 R contains potential frameshift; hypothetical protein complement(720858..721121) Streptococcus pneumoniae G54 6480041 YP_002037456.1 CDS SPG_0741 NC_011072.1 721391 721741 D identified by match to protein family HMM PF01710; IS630-Spn1 transposase 721391..721741 Streptococcus pneumoniae G54 6478975 YP_002037457.1 CDS SPG_0742 NC_011072.1 721900 722040 D IS630-Spn1 transposase 721900..722040 Streptococcus pneumoniae G54 6480372 YP_002037458.1 CDS SPG_0743 NC_011072.1 722550 724808 R identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; ATP-dependent Clp protease ATP-binding subunit ClpE complement(722550..724808) Streptococcus pneumoniae G54 6480594 YP_002037459.1 CDS SPG_0744 NC_011072.1 725037 725267 R identified by match to protein family HMM PF08796; hypothetical protein complement(725037..725267) Streptococcus pneumoniae G54 6479131 YP_002037460.1 CDS SPG_0745 NC_011072.1 725457 726140 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 725457..726140 Streptococcus pneumoniae G54 6478822 YP_002037461.1 CDS SPG_0746 NC_011072.1 726140 726874 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 726140..726874 Streptococcus pneumoniae G54 6479427 YP_002037462.1 CDS SPG_0747 NC_011072.1 727007 727885 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 727007..727885 Streptococcus pneumoniae G54 6480721 YP_002037463.1 CDS SPG_0748 NC_011072.1 728027 728899 D identified by match to protein family HMM PF01256; match to protein family HMM TIGR00196; YjeF-like protein 728027..728899 Streptococcus pneumoniae G54 6479026 YP_002037464.1 CDS ripA NC_011072.1 729181 729864 D Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 729181..729864 Streptococcus pneumoniae G54 6478730 YP_002037465.1 CDS SPG_0750 NC_011072.1 729878 731089 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 729878..731089 Streptococcus pneumoniae G54 6480030 YP_002037466.1 CDS SPG_0751 NC_011072.1 731091 731633 D identified by match to protein family HMM PF08002; hypothetical protein 731091..731633 Streptococcus pneumoniae G54 6479766 YP_002037467.1 CDS pnp NC_011072.1 731649 732458 D catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 731649..732458 Streptococcus pneumoniae G54 6480067 YP_002037468.1 CDS SPG_0753 NC_011072.1 732934 733329 D hypothetical protein 732934..733329 Streptococcus pneumoniae G54 6478838 YP_002037469.1 CDS SPG_0754 NC_011072.1 733339 733914 D hypothetical protein 733339..733914 Streptococcus pneumoniae G54 6480311 YP_002037470.1 CDS SPG_0755 NC_011072.1 733939 734451 D hypothetical protein 733939..734451 Streptococcus pneumoniae G54 6478680 YP_002037471.1 CDS deoD NC_011072.1 735105 735815 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 735105..735815 Streptococcus pneumoniae G54 6478788 YP_002037472.1 CDS SPG_0757 NC_011072.1 735838 736362 R topology modulation protein complement(735838..736362) Streptococcus pneumoniae G54 6478666 YP_002037473.1 CDS rpsT NC_011072.1 736415 736651 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(736415..736651) Streptococcus pneumoniae G54 6480155 YP_002037474.1 CDS coaA NC_011072.1 736719 737639 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(736719..737639) Streptococcus pneumoniae G54 6480197 YP_002037475.1 CDS SPG_0760 NC_011072.1 737829 738065 D hypothetical protein 737829..738065 Streptococcus pneumoniae G54 6479629 YP_002037476.1 CDS SPG_0761 NC_011072.1 738439 739029 D identified by match to protein family HMM PF05175; methyltransferase small domain 738439..739029 Streptococcus pneumoniae G54 6479614 YP_002037477.1 CDS pdp NC_011072.1 739026 740303 D Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 739026..740303 Streptococcus pneumoniae G54 6479894 YP_002037478.1 CDS deoC NC_011072.1 740321 740983 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 740321..740983 Streptococcus pneumoniae G54 6478793 YP_002037479.1 CDS SPG_0764 NC_011072.1 740970 741359 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 740970..741359 Streptococcus pneumoniae G54 6480462 YP_002037480.1 CDS SPG_0765 NC_011072.1 741450 742502 D identified by match to protein family HMM PF02608; membrane protein 741450..742502 Streptococcus pneumoniae G54 6479418 YP_002037481.1 CDS SPG_0766 NC_011072.1 742646 744181 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 742646..744181 Streptococcus pneumoniae G54 6479417 YP_002037482.1 CDS SPG_0767 NC_011072.1 744174 745232 D identified by match to protein family HMM PF02653; ABC transporter permease 744174..745232 Streptococcus pneumoniae G54 6480619 YP_002037483.1 CDS SPG_0768 NC_011072.1 745235 746191 D identified by match to protein family HMM PF02653; ABC transporter permease 745235..746191 Streptococcus pneumoniae G54 6479557 YP_002037484.1 CDS SPG_0769 NC_011072.1 746275 746487 D IS3-Spn1 transposase 746275..746487 Streptococcus pneumoniae G54 6479353 YP_002037485.1 CDS SPG_0770 NC_011072.1 746624 746791 D IS3-Spn1 transposase 746624..746791 Streptococcus pneumoniae G54 6479229 YP_002037486.1 CDS SPG_0771 NC_011072.1 746791 747525 D identified by match to protein family HMM PF00665; IS3-Spn1 transposase 746791..747525 Streptococcus pneumoniae G54 6480371 YP_002037487.1 CDS SPG_0772 NC_011072.1 747657 748298 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY complement(747657..748298) Streptococcus pneumoniae G54 6478656 YP_002037488.1 CDS parE NC_011072.1 748434 750377 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 748434..750377 Streptococcus pneumoniae G54 6480455 YP_002037489.1 CDS SPG_0774 NC_011072.1 750498 750623 D hypothetical protein 750498..750623 Streptococcus pneumoniae G54 6479164 YP_002037490.1 CDS parC NC_011072.1 750797 753268 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 750797..753268 Streptococcus pneumoniae G54 6479292 YP_002037491.1 CDS SPG_0776 NC_011072.1 753378 754400 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 753378..754400 Streptococcus pneumoniae G54 6479757 YP_002037492.1 CDS SPG_0777 NC_011072.1 754456 755160 D identified by glimmer; putative; hypothetical protein 754456..755160 Streptococcus pneumoniae G54 6479343 YP_002037493.1 CDS SPG_0778 NC_011072.1 755225 755914 D identified by glimmer; putative; hypothetical protein 755225..755914 Streptococcus pneumoniae G54 6479971 YP_002037494.1 CDS SPG_0779 NC_011072.1 755911 756834 D identified by glimmer; putative; hypothetical protein 755911..756834 Streptococcus pneumoniae G54 6479868 YP_002037495.1 CDS SPG_0780 NC_011072.1 756849 757493 D catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 756849..757493 Streptococcus pneumoniae G54 6480655 YP_002037496.1 CDS SPG_0781 NC_011072.1 757661 757891 D hypothetical protein 757661..757891 Streptococcus pneumoniae G54 6479657 YP_002037497.1 CDS rpsA NC_011072.1 758264 759466 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 758264..759466 Streptococcus pneumoniae G54 6480373 YP_002037498.1 CDS SPG_0785 NC_011072.1 759550 760068 R IS1167 transposase complement(759550..760068) Streptococcus pneumoniae G54 6480062 YP_002037499.1 CDS SPG_0786 NC_011072.1 760349 760867 R IS1167 transposase complement(760349..760867) Streptococcus pneumoniae G54 6479235 YP_002037500.1 CDS SPG_0787 NC_011072.1 761060 761557 D hypothetical protein 761060..761557 Streptococcus pneumoniae G54 6478744 YP_002037501.1 CDS dnaX NC_011072.1 761557 763212 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 761557..763212 Streptococcus pneumoniae G54 6480733 YP_002037502.1 CDS SPG_0789 NC_011072.1 763312 763434 D hypothetical protein 763312..763434 Streptococcus pneumoniae G54 6480747 YP_002037503.1 CDS SPG_0790 NC_011072.1 763584 764354 D identified by match to protein family HMM PF00005; match to protein family HMM TIGR01978; FeS assembly ATPase SufC 763584..764354 Streptococcus pneumoniae G54 6479234 YP_002037504.1 CDS SPG_0791 NC_011072.1 764382 765644 D identified by match to protein family HMM PF01458; match to protein family HMM TIGR01981; FeS assembly protein SufD 764382..765644 Streptococcus pneumoniae G54 6479941 YP_002037505.1 CDS SPG_0792 NC_011072.1 765655 766881 D identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM TIGR01979; cysteine desulfurase 765655..766881 Streptococcus pneumoniae G54 6478923 YP_002037506.1 CDS SPG_0793 NC_011072.1 766868 767308 D identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994; NifU family protein 766868..767308 Streptococcus pneumoniae G54 6479309 YP_002037507.1 CDS SPG_0794 NC_011072.1 767362 768774 D identified by match to protein family HMM PF01458; match to protein family HMM TIGR01980; FeS assembly protein SufB 767362..768774 Streptococcus pneumoniae G54 6480341 YP_002037508.1 CDS SPG_0795 NC_011072.1 769005 770246 R identified by match to protein family HMM PF00144; match to protein family HMM PF00768; match to protein family HMM PF07943; penicillin-binding protein 3, D-alanyl-D-alanine carboxypeptidase complement(769005..770246) Streptococcus pneumoniae G54 6480531 YP_002037509.1 CDS SPG_0796 NC_011072.1 770349 771458 D identified by match to protein family HMM PF01594; hypothetical protein 770349..771458 Streptococcus pneumoniae G54 6479916 YP_002037510.1 CDS SPG_0799 NC_011072.1 772871 773611 D identified by similarity to GB:AAK75002.1; match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; transcriptional repressor fructose operon 772871..773611 Streptococcus pneumoniae G54 6480685 YP_002037511.1 CDS SPG_0800 NC_011072.1 773608 774519 D identified by match to protein family HMM PF00294; match to protein family HMM TIGR03168; 1-phosphofructokinase 773608..774519 Streptococcus pneumoniae G54 6479295 YP_002037512.1 CDS SPG_0801 NC_011072.1 774516 776468 D identified by match to protein family HMM PF00359; match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR00848; match to protein family HMM TIGR01427; PTS system transporter subunit IIBCA 774516..776468 Streptococcus pneumoniae G54 6478905 YP_002037513.1 CDS SPG_0802 NC_011072.1 776489 776638 D identified by glimmer; putative; hypothetical protein 776489..776638 Streptococcus pneumoniae G54 6479241 YP_002037514.1 CDS SPG_0803 NC_011072.1 776554 778857 D identified by match to protein family HMM PF01580; FtsK/SpoIIIE family 776554..778857 Streptococcus pneumoniae G54 6480438 YP_002037515.1 CDS SPG_0804 NC_011072.1 778902 779330 R hypothetical protein complement(778902..779330) Streptococcus pneumoniae G54 6479821 YP_002037516.1 CDS SPG_0805 NC_011072.1 779468 780610 D identified by match to protein family HMM PF00266; class V aminotransferase 779468..780610 Streptococcus pneumoniae G54 6478801 YP_002037517.1 CDS thiI NC_011072.1 780619 781833 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 780619..781833 Streptococcus pneumoniae G54 6480585 YP_002037518.1 CDS SPG_0807 NC_011072.1 781968 782540 D contains potential frameshift; identified by glimmer; putative; hypothetical protein 781968..782540 Streptococcus pneumoniae G54 6480241 YP_002037519.1 CDS SPG_0808 NC_011072.1 782599 782781 D contains potential frameshift; hypothetical protein 782599..782781 Streptococcus pneumoniae G54 6479120 YP_002037520.1 CDS SPG_0809 NC_011072.1 782803 783138 D hypothetical protein 782803..783138 Streptococcus pneumoniae G54 6479682 YP_002037521.1 CDS SPG_0810 NC_011072.1 783138 783542 D hypothetical protein 783138..783542 Streptococcus pneumoniae G54 6479183 YP_002037522.1 CDS SPG_0811 NC_011072.1 783555 784721 D identified by glimmer; putative; hypothetical protein 783555..784721 Streptococcus pneumoniae G54 6480352 YP_002037523.1 CDS SPG_0812 NC_011072.1 785229 786722 D identified by similarity to GB:AAK99594.1; match to protein family HMM PF02384; type I restriction-modification system subunit M 785229..786722 Streptococcus pneumoniae G54 6480806 YP_002037524.1 CDS SPG_0813 NC_011072.1 786735 787856 D identified by match to protein family HMM PF01420; type I restriction-modification system subunit S 786735..787856 Streptococcus pneumoniae G54 6478697 YP_002037525.1 CDS SPG_0814 NC_011072.1 787916 788152 D hypothetical protein 787916..788152 Streptococcus pneumoniae G54 6480796 YP_002037526.1 CDS SPG_0815 NC_011072.1 788149 788562 D identified by match to protein family HMM PF05012; match to protein family HMM TIGR01550; prophage maintenance system killer protein 788149..788562 Streptococcus pneumoniae G54 6479647 YP_002037527.1 CDS SPG_0816 NC_011072.1 788680 789645 D identified by match to protein family HMM PF00589; match to protein family HMM PF02899; phage integrase family integrase/recombinase 788680..789645 Streptococcus pneumoniae G54 6478956 YP_002037528.1 CDS SPG_0817 NC_011072.1 789679 790254 D identified by match to protein family HMM PF01420; Type I restriction modification DNA specificity domain 789679..790254 Streptococcus pneumoniae G54 6480177 YP_002037529.1 CDS SPG_0818 NC_011072.1 790284 793634 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04313; match to protein family HMM PF04851; type I restriction-modification system subunit R 790284..793634 Streptococcus pneumoniae G54 6480637 YP_002037530.1 CDS argR1 NC_011072.1 794221 794691 R identified by match to protein family HMM PF01316; match to protein family HMM PF02863; arginine repressor complement(794221..794691) Streptococcus pneumoniae G54 6480450 YP_002037531.1 CDS SPG_0820 NC_011072.1 794708 796981 R catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase complement(794708..796981) Streptococcus pneumoniae G54 6479115 YP_002037532.1 CDS dnaE NC_011072.1 797329 800430 D Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 797329..800430 Streptococcus pneumoniae G54 6479775 YP_002037533.1 CDS pfkA NC_011072.1 800513 801520 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 800513..801520 Streptococcus pneumoniae G54 6478722 YP_002037534.1 CDS SPG_0823 NC_011072.1 801579 802136 D contains potential frameshift; identified by match to protein family HMM PF00224; pyruvate kinase 801579..802136 Streptococcus pneumoniae G54 6479101 YP_002037535.1 CDS SPG_0824 NC_011072.1 802133 803083 D contains potential frameshift; identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; pyruvate kinase 802133..803083 Streptococcus pneumoniae G54 6478870 YP_002037536.1 CDS SPG_0825 NC_011072.1 804157 804303 R identified by glimmer; putative; hypothetical protein complement(804157..804303) Streptococcus pneumoniae G54 6480445 YP_002037537.1 CDS SPG_0826 NC_011072.1 804848 805720 D hypothetical protein 804848..805720 Streptococcus pneumoniae G54 6478935 YP_002037538.1 CDS SPG_0827 NC_011072.1 805827 806210 R degenarate transposase complement(805827..806210) Streptococcus pneumoniae G54 6479776 YP_002037539.1 CDS SPG_0828 NC_011072.1 806353 806664 D hypothetical protein 806353..806664 Streptococcus pneumoniae G54 6478944 YP_002037540.1 CDS SPG_0829 NC_011072.1 806668 807384 D hypothetical protein 806668..807384 Streptococcus pneumoniae G54 6479240 YP_002037541.1 CDS SPG_0830 NC_011072.1 807513 808328 R identified by glimmer; putative; hypothetical protein complement(807513..808328) Streptococcus pneumoniae G54 6479075 YP_002037542.1 CDS SPG_0831 NC_011072.1 808325 809230 R identified by match to protein family HMM PF03773; hypothetical protein complement(808325..809230) Streptococcus pneumoniae G54 6480469 YP_002037543.1 CDS SPG_0832 NC_011072.1 809231 809362 R hypothetical protein complement(809231..809362) Streptococcus pneumoniae G54 6479730 YP_002037544.1 CDS SPG_0833 NC_011072.1 809642 811771 D identified by similarity to GB:AAK99612.1; match to protein family HMM PF00575; S1 RNA binding domain 809642..811771 Streptococcus pneumoniae G54 6479763 YP_002037545.1 CDS SPG_0834 NC_011072.1 812035 812187 D identified by glimmer; putative; hypothetical protein 812035..812187 Streptococcus pneumoniae G54 6478939 YP_002037546.1 CDS SPG_0835 NC_011072.1 812266 812538 D identified by match to protein family HMM PF04024; hypothetical protein 812266..812538 Streptococcus pneumoniae G54 6480481 YP_002037547.1 CDS SPG_0836 NC_011072.1 813512 814270 D identified by match to protein family HMM PF00005; match to protein family HMM TIGR03608; ABC transporter ATP-binding protein 813512..814270 Streptococcus pneumoniae G54 6480044 YP_002037548.1 CDS SPG_0837 NC_011072.1 814272 816260 D identified by match to protein family HMM PF02687; ABC transporter permease 814272..816260 Streptococcus pneumoniae G54 6478856 YP_002037549.1 CDS SPG_0838 NC_011072.1 816302 816892 R identified by match to protein family HMM PF01988; hypothetical protein complement(816302..816892) Streptococcus pneumoniae G54 6480219 YP_002037550.1 CDS SPG_0839 NC_011072.1 816918 818015 R identified by match to protein family HMM PF00665; IS1239 transposase complement(816918..818015) Streptococcus pneumoniae G54 6479782 YP_002037551.1 CDS cad NC_011072.1 818630 820105 D identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM PF01276; match to protein family HMM PF03711; arginine decarboxylase 818630..820105 Streptococcus pneumoniae G54 6479087 YP_002037552.1 CDS SPG_0840 NC_011072.1 820071 820196 R hypothetical protein complement(820071..820196) Streptococcus pneumoniae G54 6480343 YP_002037553.1 CDS SPG_0842 NC_011072.1 820228 821358 R identified by match to protein family HMM PF02371; transposase complement(820228..821358) Streptococcus pneumoniae G54 6480794 YP_002037554.1 CDS SPG_0843 NC_011072.1 821445 821582 D identified by glimmer; putative; hypothetical protein 821445..821582 Streptococcus pneumoniae G54 6479548 YP_002037555.1 CDS speE NC_011072.1 821613 822473 D catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 821613..822473 Streptococcus pneumoniae G54 6480094 YP_002037556.1 CDS SPG_0845 NC_011072.1 822470 823729 D identified by match to protein family HMM PF03435; saccharopine dehydrogenase 822470..823729 Streptococcus pneumoniae G54 6478836 YP_002037557.1 CDS nspC NC_011072.1 823729 824856 D identified by match to protein family HMM PF00278; match to protein family HMM TIGR01047; carboxynorspermidine decarboxylase 823729..824856 Streptococcus pneumoniae G54 6479010 YP_002037558.1 CDS SPG_0847 NC_011072.1 824853 825992 D catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis; agmatine deiminase 824853..825992 Streptococcus pneumoniae G54 6480351 YP_002037559.1 CDS SPG_0848 NC_011072.1 825949 826824 D identified by match to protein family HMM PF00795; match to protein family HMM TIGR03381; N-carbamoylputrescine amidase 825949..826824 Streptococcus pneumoniae G54 6480698 YP_002037560.1 CDS SPG_0849 NC_011072.1 827005 827814 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(827005..827814) Streptococcus pneumoniae G54 6480646 YP_002037561.1 CDS SPG_0850 NC_011072.1 828086 828307 D hypothetical protein 828086..828307 Streptococcus pneumoniae G54 6480506 YP_002037562.1 CDS SPG_0851 NC_011072.1 828361 829032 D identified by match to protein family HMM PF02517; CAAX amino terminal protease family 828361..829032 Streptococcus pneumoniae G54 6479100 YP_002037563.1 CDS SPG_0852 NC_011072.1 829083 829280 R hypothetical protein complement(829083..829280) Streptococcus pneumoniae G54 6480421 YP_002037564.1 CDS smrC NC_011072.1 829273 830181 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; regulator of CbpE 829273..830181 Streptococcus pneumoniae G54 6480129 YP_002037565.1 CDS SPG_0854 NC_011072.1 830178 830639 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 830178..830639 Streptococcus pneumoniae G54 6479263 YP_002037566.1 CDS SPG_0855 NC_011072.1 830629 831516 D identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase D 830629..831516 Streptococcus pneumoniae G54 6480732 YP_002037567.1 CDS cbpE NC_011072.1 831519 833402 D identified by match to protein family HMM PF00753; match to protein family HMM PF01473; choline binding protein E 831519..833402 Streptococcus pneumoniae G54 6478968 YP_002037568.1 CDS SPG_0857 NC_011072.1 833503 834090 D contains potential frameshift; identified by match to protein family HMM PF00696; match to protein family HMM TIGR01027; glutamate 5-kinase 833503..834090 Streptococcus pneumoniae G54 6480501 YP_002037569.1 CDS SPG_0858 NC_011072.1 834062 834613 D contains potential frameshift; identified by match to protein family HMM PF01472; glutamate 5-kinase 834062..834613 Streptococcus pneumoniae G54 6479274 YP_002037570.1 CDS proA NC_011072.1 834623 835885 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 834623..835885 Streptococcus pneumoniae G54 6479070 YP_002037571.1 CDS proC NC_011072.1 835889 836686 D identified by match to protein family HMM PF01210; match to protein family HMM PF03807; match to protein family HMM TIGR00112; pyrroline-5-carboxylate reductase 835889..836686 Streptococcus pneumoniae G54 6480589 YP_002037572.1 CDS tmk NC_011072.1 836906 837544 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 836906..837544 Streptococcus pneumoniae G54 6479365 YP_002037573.1 CDS holB NC_011072.1 837541 838431 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 837541..838431 Streptococcus pneumoniae G54 6480228 YP_002037574.1 CDS SPG_0863 NC_011072.1 838471 838788 D in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 838471..838788 Streptococcus pneumoniae G54 6480011 YP_002037575.1 CDS SPG_0864 NC_011072.1 838791 839660 D identified by match to protein family HMM PF00590; match to protein family HMM TIGR00096; hypothetical protein 838791..839660 Streptococcus pneumoniae G54 6480771 YP_002037576.1 CDS SPG_0865 NC_011072.1 839887 840405 D identified by match to protein family HMM PF08020; hypothetical protein 839887..840405 Streptococcus pneumoniae G54 6480601 YP_002037577.1 CDS SPG_0866 NC_011072.1 840514 840651 D phage protein, point mutation 840514..840651 Streptococcus pneumoniae G54 6480042 YP_002037578.1 CDS SPG_0868 NC_011072.1 840658 841161 D phage protein, point mutation 840658..841161 Streptococcus pneumoniae G54 6479340 YP_002037579.1 CDS SPG_0867 NC_011072.1 841150 841539 R identified by match to protein family HMM PF01609; transposase complement(841150..841539) Streptococcus pneumoniae G54 6479970 YP_002037580.1 CDS SPG_0869 NC_011072.1 841767 841955 R degenarate transposase complement(841767..841955) Streptococcus pneumoniae G54 6478934 YP_002037581.1 CDS SPG_0870 NC_011072.1 842449 843783 D TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 842449..843783 Streptococcus pneumoniae G54 6479171 YP_002037582.1 CDS pyrH NC_011072.1 843867 844604 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 843867..844604 Streptococcus pneumoniae G54 6478670 YP_002037583.1 CDS frr NC_011072.1 844613 845170 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 844613..845170 Streptococcus pneumoniae G54 6478949 YP_002037584.1 CDS SPG_0873 NC_011072.1 845191 846084 D hypothetical protein 845191..846084 Streptococcus pneumoniae G54 6478904 YP_002037585.1 CDS SPG_0874 NC_011072.1 846093 846308 D identified by match to protein family HMM PF06855; hypothetical protein 846093..846308 Streptococcus pneumoniae G54 6479057 YP_002037586.1 CDS SPG_0875 NC_011072.1 846394 847398 D identified by match to protein family HMM PF02562; PhoH family protein 846394..847398 Streptococcus pneumoniae G54 6479282 YP_002037587.1 CDS SPG_0876 NC_011072.1 847506 848075 D identified by match to protein family HMM PF00583; GNAT family acetyltransferase 847506..848075 Streptococcus pneumoniae G54 6480090 YP_002037588.1 CDS comEA NC_011072.1 848143 848793 D identified by match to protein family HMM PF00633; match to protein family HMM TIGR00426; match to protein family HMM TIGR01259; competence protein ComEA 848143..848793 Streptococcus pneumoniae G54 6479091 YP_002037589.1 CDS comEC NC_011072.1 848777 851017 D identified by match to protein family HMM PF03772; match to protein family HMM TIGR00360; match to protein family HMM TIGR00361; competence protein ComEC 848777..851017 Streptococcus pneumoniae G54 6480098 YP_002037590.1 CDS SPG_0879 NC_011072.1 851238 851384 D hypothetical protein 851238..851384 Streptococcus pneumoniae G54 6479858 YP_002037591.1 CDS SPG_0880 NC_011072.1 851416 852003 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 851416..852003 Streptococcus pneumoniae G54 6479154 YP_002037592.1 CDS SPG_0881 NC_011072.1 852007 853167 D identified by glimmer; putative; hypothetical protein 852007..853167 Streptococcus pneumoniae G54 6479848 YP_002037593.1 CDS SPG_0882 NC_011072.1 853206 853340 R identified by glimmer; putative; hypothetical protein complement(853206..853340) Streptococcus pneumoniae G54 6479121 YP_002037594.1 CDS infC NC_011072.1 853469 854026 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 853469..854026 Streptococcus pneumoniae G54 6479399 YP_002037595.1 CDS rpmI NC_011072.1 854059 854259 D identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001; 50S ribosomal protein L35 854059..854259 Streptococcus pneumoniae G54 6479180 YP_002037596.1 CDS rplT NC_011072.1 854311 854670 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 854311..854670 Streptococcus pneumoniae G54 6478849 YP_002037597.1 CDS lguL NC_011072.1 854728 855108 D identified by match to protein family HMM PF00903; lactoylglutathione lyase 854728..855108 Streptococcus pneumoniae G54 6479499 YP_002037598.1 CDS pyrDII NC_011072.1 855358 856158 D responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+); dihydroorotate dehydrogenase electron transfer subunit 855358..856158 Streptococcus pneumoniae G54 6480527 YP_002037599.1 CDS SPG_0888 NC_011072.1 856169 857107 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 856169..857107 Streptococcus pneumoniae G54 6479627 YP_002037600.1 CDS lytB NC_011072.1 857206 859314 D identified by match to protein family HMM PF01473; match to protein family HMM PF01832; endo-beta-N-acetylglucosaminidase 857206..859314 Streptococcus pneumoniae G54 6479000 YP_002037601.1 CDS flpA NC_011072.1 859375 861030 R identified by match to protein family HMM PF05670; match to protein family HMM PF05833; fibronectin-binding protein-like protein A complement(859375..861030) Streptococcus pneumoniae G54 6479038 YP_002037602.1 CDS SPG_0891 NC_011072.1 861135 861632 D identified by match to protein family HMM PF02130; match to protein family HMM TIGR00043; putative metalloprotease 861135..861632 Streptococcus pneumoniae G54 6480213 YP_002037603.1 CDS dgkA NC_011072.1 861613 862008 D identified by match to protein family HMM PF01219; diacylglycerol kinase 861613..862008 Streptococcus pneumoniae G54 6479926 YP_002037604.1 CDS era NC_011072.1 862025 862924 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 862025..862924 Streptococcus pneumoniae G54 6478987 YP_002037605.1 CDS fpg NC_011072.1 862973 863797 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 862973..863797 Streptococcus pneumoniae G54 6479345 YP_002037606.1 CDS coaE NC_011072.1 863797 864402 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 863797..864402 Streptococcus pneumoniae G54 6480516 YP_002037607.1 CDS SPG_0896 NC_011072.1 864389 865588 D identified by match to protein family HMM PF07690; multi-drug resistance efflux pump 864389..865588 Streptococcus pneumoniae G54 6480301 YP_002037608.1 CDS secG NC_011072.1 865777 866010 D identified by match to protein family HMM PF03840; match to protein family HMM TIGR00810; preprotein translocase subunit SecG 865777..866010 Streptococcus pneumoniae G54 6478936 YP_002037609.1 CDS rnr NC_011072.1 866112 868466 D also known as vacB; identified by match to protein family HMM PF00575; match to protein family HMM PF00773; match to protein family HMM PF08206; match to protein family HMM TIGR00358; match to protein family HMM TIGR02063; ribonuclease R 866112..868466 Streptococcus pneumoniae G54 6480348 YP_002037610.1 CDS smpB NC_011072.1 868429 868896 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 868429..868896 Streptococcus pneumoniae G54 6480416 YP_002037611.1 CDS tehB NC_011072.1 868912 869772 D with TehA confers resistance to tellurite; tellurite resistance protein TehB 868912..869772 Streptococcus pneumoniae G54 6480092 YP_002037612.1 CDS coiA NC_011072.1 869845 870798 D identified by match to protein family HMM PF06054; competence protein CoiA 869845..870798 Streptococcus pneumoniae G54 6478960 YP_002037613.1 CDS pepB NC_011072.1 870817 872619 D identified by match to protein family HMM PF01432; match to protein family HMM PF08439; match to protein family HMM TIGR00181; group B oligopeptidase PepB 870817..872619 Streptococcus pneumoniae G54 6479445 YP_002037614.1 CDS SPG_0903 NC_011072.1 872621 873334 D identified by match to protein family HMM PF01596; match to protein family HMM PF08241; hypothetical protein 872621..873334 Streptococcus pneumoniae G54 6480435 YP_002037615.1 CDS SPG_0904 NC_011072.1 873401 874060 D contains potential frameshift; foldase protein PrsA 873401..874060 Streptococcus pneumoniae G54 6479169 YP_002037616.1 CDS SPG_0905 NC_011072.1 874044 874169 D contains potential frameshift; foldase protein PrsA 874044..874169 Streptococcus pneumoniae G54 6479346 YP_002037617.1 CDS SPG_0906 NC_011072.1 874205 874336 D contains potential frameshift; foldase protein PrsA 874205..874336 Streptococcus pneumoniae G54 6479047 YP_002037618.1 CDS SPG_0907 NC_011072.1 874525 874794 R IS3-Spn1 transposase complement(874525..874794) Streptococcus pneumoniae G54 6478906 YP_002037619.1 CDS SPG_0908 NC_011072.1 874794 874928 R IS3-Spn1 transposase complement(874794..874928) Streptococcus pneumoniae G54 6479384 YP_002037620.1 CDS SPG_0909 NC_011072.1 875555 876175 R identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein complement(875555..876175) Streptococcus pneumoniae G54 6478684 YP_002037621.1 CDS SPG_0910 NC_011072.1 876175 876657 R identified by match to protein family HMM PF04073; regulatory protein complement(876175..876657) Streptococcus pneumoniae G54 6479889 YP_002037622.1 CDS SPG_0911 NC_011072.1 876657 877499 R identified by match to protein family HMM PF04018; hypothetical protein complement(876657..877499) Streptococcus pneumoniae G54 6479777 YP_002037623.1 CDS SPG_0912 NC_011072.1 877594 878382 R identified by glimmer; putative; hypothetical protein complement(877594..878382) Streptococcus pneumoniae G54 6479298 YP_002037624.1 CDS glmU NC_011072.1 878526 879905 D forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 878526..879905 Streptococcus pneumoniae G54 6479065 YP_002037625.1 CDS SPG_0914 NC_011072.1 879915 880460 D identified by match to protein family HMM PF00293; NUDIX family hydrolase 879915..880460 Streptococcus pneumoniae G54 6479386 YP_002037626.1 CDS SPG_0915 NC_011072.1 880472 880786 D hypothetical protein 880472..880786 Streptococcus pneumoniae G54 6480201 YP_002037627.1 CDS SPG_0916 NC_011072.1 880803 881495 D enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 880803..881495 Streptococcus pneumoniae G54 6479043 YP_002037628.1 CDS SPG_0917 NC_011072.1 881572 882063 D identified by match to protein family HMM PF04394; hypothetical protein 881572..882063 Streptococcus pneumoniae G54 6479764 YP_002037629.1 CDS SPG_0918 NC_011072.1 882161 882751 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 882161..882751 Streptococcus pneumoniae G54 6479361 YP_002037630.1 CDS SPG_0919 NC_011072.1 882760 884523 D identified by match to protein family HMM PF03009; hypothetical protein 882760..884523 Streptococcus pneumoniae G54 6480754 YP_002037631.1 CDS SPG_0920 NC_011072.1 884814 886160 D identified by match to protein family HMM PF01609; IS1380-Spn1 transposase 884814..886160 Streptococcus pneumoniae G54 6478937 YP_002037632.1 CDS SPG_0921 NC_011072.1 886445 886774 D identified by match to protein family HMM PF01710; IS630-Spn1 transposase 886445..886774 Streptococcus pneumoniae G54 6479293 YP_002037633.1 CDS SPG_0922 NC_011072.1 887254 887454 D hypothetical protein 887254..887454 Streptococcus pneumoniae G54 6478814 YP_002037634.1 CDS SPG_0923 NC_011072.1 887479 887895 D hypothetical protein 887479..887895 Streptococcus pneumoniae G54 6480015 YP_002037635.1 CDS SPG_0924 NC_011072.1 888126 888833 D identified by match to protein family HMM PF02683; cytochrome c-type biogenesis protein CcdA 888126..888833 Streptococcus pneumoniae G54 6479792 YP_002037636.1 CDS SPG_0925 NC_011072.1 888844 889401 D identified by match to protein family HMM PF00578; match to protein family HMM PF08534; thioredoxin family protein 888844..889401 Streptococcus pneumoniae G54 6479626 YP_002037637.1 CDS SPG_0926 NC_011072.1 889775 891166 D identified by match to protein family HMM PF00324; amino acid permease 889775..891166 Streptococcus pneumoniae G54 6479383 YP_002037638.1 CDS SPG_0927 NC_011072.1 891309 892226 D identified by match to protein family HMM PF01297; adhesion lipoprotein 891309..892226 Streptococcus pneumoniae G54 6478925 YP_002037639.1 CDS phtD NC_011072.1 892234 894084 D contains potential frameshift; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; histidine triad protein D 892234..894084 Streptococcus pneumoniae G54 6479018 YP_002037640.1 CDS phtD NC_011072.1 894104 894781 D contains potential frameshift; histidine triad protein D 894104..894781 Streptococcus pneumoniae G54 6479675 YP_002037641.1 CDS phtD NC_011072.1 894991 898110 D contains potential frameshift; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; histidine triad protein D 894991..898110 Streptococcus pneumoniae G54 6479504 YP_002037642.1 CDS phtE NC_011072.1 898940 899509 D identified by match to protein family HMM PF04270; histidine triad protein E 898940..899509 Streptococcus pneumoniae G54 6478833 YP_002037643.1 CDS SPG_0932 NC_011072.1 899804 900433 D identified by glimmer; putative; hypothetical protein 899804..900433 Streptococcus pneumoniae G54 6479634 YP_002037644.1 CDS SPG_0933 NC_011072.1 900469 900864 R contains potential frameshift; peptidase T complement(900469..900864) Streptococcus pneumoniae G54 6478989 YP_002037645.1 CDS SPG_0934 NC_011072.1 900842 901693 R contains potential frameshift; identified by match to protein family HMM PF07687; match to protein family HMM TIGR01882; peptidase T complement(900842..901693) Streptococcus pneumoniae G54 6480586 YP_002037646.1 CDS hemH NC_011072.1 901940 902941 D identified by match to protein family HMM PF00762; match to protein family HMM TIGR00109; ferrochelatase 901940..902941 Streptococcus pneumoniae G54 6478955 YP_002037647.1 CDS mscL NC_011072.1 902983 903360 R identified by match to protein family HMM PF01741; match to protein family HMM TIGR00220; large conductance mechanosensitive channel protein complement(902983..903360) Streptococcus pneumoniae G54 6480756 YP_002037648.1 CDS SPG_0937 NC_011072.1 903442 903873 R identified by match to protein family HMM PF04138; GtrA family protein complement(903442..903873) Streptococcus pneumoniae G54 6480709 YP_002037649.1 CDS SPG_0938 NC_011072.1 903996 904505 D identified by match to protein family HMM PF06177; hypothetical protein 903996..904505 Streptococcus pneumoniae G54 6479669 YP_002037650.1 CDS asd NC_011072.1 905020 906096 D catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 905020..906096 Streptococcus pneumoniae G54 6480648 YP_002037651.1 CDS dapA NC_011072.1 906152 907087 D catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 906152..907087 Streptococcus pneumoniae G54 6479398 YP_002037652.1 CDS trmE NC_011072.1 907134 908507 R in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE complement(907134..908507) Streptococcus pneumoniae G54 6480418 YP_002037653.1 CDS SPG_0943 NC_011072.1 908645 908827 R 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase complement(908645..908827) Streptococcus pneumoniae G54 6480786 YP_002037654.1 CDS tdk NC_011072.1 908951 909541 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 908951..909541 Streptococcus pneumoniae G54 6479656 YP_002037655.1 CDS prfA NC_011072.1 909538 910617 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 909538..910617 Streptococcus pneumoniae G54 6479368 YP_002037656.1 CDS SPG_0946 NC_011072.1 910617 911456 D identified by match to protein family HMM PF05175; match to protein family HMM PF08241; match to protein family HMM PF08242; match to protein family HMM TIGR00536; methyltransferase, HemK family protein 910617..911456 Streptococcus pneumoniae G54 6480568 YP_002037657.1 CDS SPG_0947 NC_011072.1 911440 912042 D identified by match to protein family HMM PF01300; match to protein family HMM TIGR00057; Sua5/YciO/YrdC/YwlC family protein 911440..912042 Streptococcus pneumoniae G54 6479552 YP_002037658.1 CDS SPG_0948 NC_011072.1 912044 912475 D identified by match to protein family HMM PF00583; GNAT family acetyltransferase 912044..912475 Streptococcus pneumoniae G54 6479936 YP_002037659.1 CDS glyA NC_011072.1 912537 913793 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 912537..913793 Streptococcus pneumoniae G54 6479492 YP_002037660.1 CDS SPG_0950 NC_011072.1 913801 914775 D hypothetical protein 913801..914775 Streptococcus pneumoniae G54 6480200 YP_002037661.1 CDS SPG_0951 NC_011072.1 914775 915389 D hypothetical protein 914775..915389 Streptococcus pneumoniae G54 6479689 YP_002037662.1 CDS SPG_0952 NC_011072.1 915463 916437 D identified by match to protein family HMM PF06207; hypothetical protein 915463..916437 Streptococcus pneumoniae G54 6480748 YP_002037663.1 CDS SPG_0953 NC_011072.1 916511 918142 D identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA 916511..918142 Streptococcus pneumoniae G54 6480557 YP_002037664.1 CDS SPG_0954 NC_011072.1 918880 919098 D hypothetical protein 918880..919098 Streptococcus pneumoniae G54 6480322 YP_002037665.1 CDS SPG_0955 NC_011072.1 919102 919371 D identified by glimmer; putative; hypothetical protein 919102..919371 Streptococcus pneumoniae G54 6479679 YP_002037666.1 CDS piaA NC_011072.1 919492 920517 D Ulijasz AT, J Bacteriol. 2004 Dec;186(23):8123-36; identified by match to protein family HMM PF01497; iron ABC transporter iron-binding protein 919492..920517 Streptococcus pneumoniae G54 6478755 YP_002037667.1 CDS piaB NC_011072.1 920507 921514 D Ulijasz AT, J Bacteriol. 2004 Dec;186(23):8123-36.; identified by match to protein family HMM PF01032; iron ABC transporter permease 920507..921514 Streptococcus pneumoniae G54 6479522 YP_002037668.1 CDS piaC NC_011072.1 921514 922521 D Ulijasz AT, J Bacteriol. 2004 Dec;186(23):8123-36.; identified by match to protein family HMM PF01032; iron ABC transporter permease 921514..922521 Streptococcus pneumoniae G54 6480364 YP_002037669.1 CDS piaD NC_011072.1 922521 923315 D Ulijasz AT, J Bacteriol. 2004 Dec;186(23):8123-36.; identified by match to protein family HMM PF00005; iron ABC transporter ATP-binding protein 922521..923315 Streptococcus pneumoniae G54 6478915 YP_002037670.1 CDS SPG_0960 NC_011072.1 924188 924502 D hypothetical protein 924188..924502 Streptococcus pneumoniae G54 6479911 YP_002037671.1 CDS SPG_0961 NC_011072.1 924812 926452 D identified by match to protein family HMM PF03389; nickase 924812..926452 Streptococcus pneumoniae G54 6478726 YP_002037672.1 CDS SPG_0962 NC_011072.1 926885 927412 D hypothetical protein 926885..927412 Streptococcus pneumoniae G54 6480706 YP_002037673.1 CDS SPG_0963 NC_011072.1 927539 928051 D identified by match to protein family HMM TIGR01714; phage replisome organizer, N-terminal region 927539..928051 Streptococcus pneumoniae G54 6480181 YP_002037674.1 CDS SPG_0964 NC_011072.1 928136 928267 D hypothetical protein 928136..928267 Streptococcus pneumoniae G54 6478932 YP_002037675.1 CDS SPG_0965 NC_011072.1 928951 929112 D hypothetical protein 928951..929112 Streptococcus pneumoniae G54 6480664 YP_002037676.1 CDS SPG_0966 NC_011072.1 929204 930883 D identified by match to protein family HMM PF00239; match to protein family HMM PF07508; resolvase family protein site-specific recombinase 929204..930883 Streptococcus pneumoniae G54 6478857 YP_002037677.1 CDS SPG_0967 NC_011072.1 931151 931717 D identified by similarity to RF:ZP_00404330.1; hypothetical protein 931151..931717 Streptococcus pneumoniae G54 6479451 YP_002037678.1 CDS SPG_0968 NC_011072.1 932038 932226 D hypothetical protein 932038..932226 Streptococcus pneumoniae G54 6479507 YP_002037679.1 CDS SPG_0969 NC_011072.1 932288 933046 D hypothetical protein 932288..933046 Streptococcus pneumoniae G54 6479077 YP_002037680.1 CDS SPG_0970 NC_011072.1 933104 933958 D identified by match to protein family HMM PF03747; hydrolase 933104..933958 Streptococcus pneumoniae G54 6480302 YP_002037681.1 CDS SPG_0971 NC_011072.1 934070 934954 D identified by match to protein family HMM PF00781; match to protein family HMM TIGR00147; hypothetical protein 934070..934954 Streptococcus pneumoniae G54 6479880 YP_002037682.1 CDS SPG_0972 NC_011072.1 935117 936244 D identified by match to protein family HMM PF00128; match to protein family HMM PF02903; neopullulanase 935117..936244 Streptococcus pneumoniae G54 6479400 YP_002037683.1 CDS SPG_0973 NC_011072.1 936241 936567 D contains potential frameshift; relaxase/mobilization nuclease domain 936241..936567 Streptococcus pneumoniae G54 6479969 YP_002037684.1 CDS SPG_0974 NC_011072.1 936603 936803 D contains potential frameshift; relaxase 936603..936803 Streptococcus pneumoniae G54 6480650 YP_002037685.1 CDS SPG_0975 NC_011072.1 936825 937529 D identified by glimmer; putative; hypothetical protein 936825..937529 Streptococcus pneumoniae G54 6479069 YP_002037686.1 CDS SPG_0976 NC_011072.1 937570 938421 R identified by match to protein family HMM TIGR01716; Rgg/GadR/MutR family transcriptional activator complement(937570..938421) Streptococcus pneumoniae G54 6479687 YP_002037687.1 CDS SPG_0977 NC_011072.1 938678 939547 D identified by glimmer; putative; hypothetical protein 938678..939547 Streptococcus pneumoniae G54 6480507 YP_002037688.1 CDS SPG_0978 NC_011072.1 939534 940256 D identified by glimmer; putative; hypothetical protein 939534..940256 Streptococcus pneumoniae G54 6480035 YP_002037689.1 CDS SPG_0979 NC_011072.1 940581 940784 D hypothetical protein 940581..940784 Streptococcus pneumoniae G54 6479838 YP_002037690.1 CDS SPG_0980 NC_011072.1 940788 941882 D identified by glimmer; putative; hypothetical protein 940788..941882 Streptococcus pneumoniae G54 6480002 YP_002037691.1 CDS SPG_0981 NC_011072.1 941885 942556 D identified by glimmer; putative; hypothetical protein 941885..942556 Streptococcus pneumoniae G54 6480795 YP_002037692.1 CDS SPG_0982 NC_011072.1 942558 943586 D identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase 942558..943586 Streptococcus pneumoniae G54 6479701 YP_002037693.1 CDS SPG_0983 NC_011072.1 943610 944854 D identified by glimmer; putative; hypothetical protein 943610..944854 Streptococcus pneumoniae G54 6479367 YP_002037694.1 CDS SPG_0984 NC_011072.1 944856 945263 D ABC transporter permease 944856..945263 Streptococcus pneumoniae G54 6480629 YP_002037695.1 CDS SPG_0985 NC_011072.1 945273 946067 D ABC transporter permease 945273..946067 Streptococcus pneumoniae G54 6479928 YP_002037696.1 CDS SPG_0986 NC_011072.1 946747 946968 D identified by match to protein family HMM PF01381; hypothetical protein 946747..946968 Streptococcus pneumoniae G54 6479914 YP_002037697.1 CDS SPG_0987 NC_011072.1 947416 947610 D degenarate transposase 947416..947610 Streptococcus pneumoniae G54 6479242 YP_002037698.1 CDS SPG_0988 NC_011072.1 947874 949103 D identified by match to protein family HMM PF01098; cell division protein FtsW 947874..949103 Streptococcus pneumoniae G54 6480514 YP_002037699.1 CDS ppc NC_011072.1 949123 951819 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 949123..951819 Streptococcus pneumoniae G54 6480017 YP_002037700.1 CDS SPG_0990 NC_011072.1 952232 953236 D identified by match to protein family HMM PF04392; hypothetical protein 952232..953236 Streptococcus pneumoniae G54 6478866 YP_002037701.1 CDS SPG_0991 NC_011072.1 953305 954171 D identified by match to protein family HMM PF02653; ABC transporter permease 953305..954171 Streptococcus pneumoniae G54 6479332 YP_002037702.1 CDS SPG_0992 NC_011072.1 954168 954926 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 954168..954926 Streptococcus pneumoniae G54 6478803 YP_002037703.1 CDS dnaG NC_011072.1 955016 956776 D synthesizes RNA primers at the replication forks; DNA primase 955016..956776 Streptococcus pneumoniae G54 6479674 YP_002037704.1 CDS rpoD NC_011072.1 956779 957888 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 956779..957888 Streptococcus pneumoniae G54 6480054 YP_002037705.1 CDS SPG_0995 NC_011072.1 957902 958231 D identified by match to protein family HMM PF01883; hypothetical protein 957902..958231 Streptococcus pneumoniae G54 6478918 YP_002037706.1 CDS SPG_0996 NC_011072.1 958346 959389 D identified by match to protein family HMM PF00534; group 1 family glycosyl transferase 958346..959389 Streptococcus pneumoniae G54 6478922 YP_002037707.1 CDS SPG_0997 NC_011072.1 959405 960730 D identified by match to protein family HMM PF00534; group 1 family glycosyl transferase 959405..960730 Streptococcus pneumoniae G54 6480014 YP_002037708.1 CDS SPG_0998 NC_011072.1 960761 960937 D identified by match to protein family HMM PF04024; hypothetical protein 960761..960937 Streptococcus pneumoniae G54 6479841 YP_002037709.1 CDS SPG_0999 NC_011072.1 960996 961130 D hypothetical protein 960996..961130 Streptococcus pneumoniae G54 6478970 YP_002037710.1 CDS obgE NC_011072.1 961200 962504 D essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 961200..962504 Streptococcus pneumoniae G54 6480599 YP_002037711.1 CDS SPG_1001 NC_011072.1 962514 962672 D hypothetical protein 962514..962672 Streptococcus pneumoniae G54 6479920 YP_002037712.1 CDS murA1 NC_011072.1 963815 965074 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 963815..965074 Streptococcus pneumoniae G54 6478931 YP_002037713.1 CDS SPG_1003 NC_011072.1 965090 965641 D identified by match to protein family HMM PF00583; GNAT family acetyltransferase 965090..965641 Streptococcus pneumoniae G54 6479663 YP_002037714.1 CDS SPG_1004 NC_011072.1 965634 966911 D identified by match to protein family HMM PF00571; match to protein family HMM PF03061; match to protein family HMM PF07085; match to protein family HMM PF08279; hypothetical protein 965634..966911 Streptococcus pneumoniae G54 6479123 YP_002037715.1 CDS SPG_1005 NC_011072.1 966927 967787 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 966927..967787 Streptococcus pneumoniae G54 6478653 YP_002037716.1 CDS SPG_1006 NC_011072.1 968012 968566 D degenarate transposase 968012..968566 Streptococcus pneumoniae G54 6480630 YP_002037717.1 CDS SPG_1007 NC_011072.1 968583 968972 D identified by match to protein family HMM PF01609; degenarate transposase 968583..968972 Streptococcus pneumoniae G54 6478972 YP_002037718.1 CDS pcrA NC_011072.1 969164 971455 D identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073; ATP-dependent DNA helicase PcrA 969164..971455 Streptococcus pneumoniae G54 6479335 YP_002037719.1 CDS radC NC_011072.1 971498 972178 D Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 971498..972178 Streptococcus pneumoniae G54 6479564 YP_002037720.1 CDS SPG_1009 NC_011072.1 972175 972864 R identified by match to protein family HMM PF00117; match to protein family HMM PF07722; glutamine amidotransferase complement(972175..972864) Streptococcus pneumoniae G54 6478847 YP_002037721.1 CDS SPG_1011 NC_011072.1 972882 973523 R modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex complement(972882..973523) Streptococcus pneumoniae G54 6480013 YP_002037722.1 CDS SPG_1012 NC_011072.1 973606 973821 R hypothetical protein complement(973606..973821) Streptococcus pneumoniae G54 6480591 YP_002037723.1 CDS SPG_1013 NC_011072.1 973829 974176 R identified by match to protein family HMM PF08866; hypothetical protein complement(973829..974176) Streptococcus pneumoniae G54 6480411 YP_002037724.1 CDS SPG_1014 NC_011072.1 974181 975296 R identified by match to protein family HMM PF00266; class V aminotransferase complement(974181..975296) Streptococcus pneumoniae G54 6479855 YP_002037725.1 CDS prs2 NC_011072.1 975306 976265 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(975306..976265) Streptococcus pneumoniae G54 6480323 YP_002037726.1 CDS SPG_1016 NC_011072.1 976378 976947 R identified by match to protein family HMM PF01928; adenylate cyclase complement(976378..976947) Streptococcus pneumoniae G54 6479612 YP_002037727.1 CDS SPG_1017 NC_011072.1 977075 977746 D identified by match to protein family HMM PF04607; pyrophosphokinase family protein 977075..977746 Streptococcus pneumoniae G54 6479442 YP_002037728.1 CDS ppnK NC_011072.1 977730 978548 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 977730..978548 Streptococcus pneumoniae G54 6480792 YP_002037729.1 CDS SPG_1019 NC_011072.1 978545 979441 D identified by match to protein family HMM PF00849; match to protein family HMM TIGR00005; RluD subfamily ribosomal large subunit pseudouridine synthase 978545..979441 Streptococcus pneumoniae G54 6479256 YP_002037730.1 CDS eutD NC_011072.1 979485 980459 D in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 979485..980459 Streptococcus pneumoniae G54 6479521 YP_002037731.1 CDS SPG_1021 NC_011072.1 980859 981158 R identified by match to protein family HMM PF02575; match to protein family HMM TIGR00103; hypothetical protein complement(980859..981158) Streptococcus pneumoniae G54 6479814 YP_002037732.1 CDS SPG_1022 NC_011072.1 981560 982258 D identified by match to protein family HMM PF06912; hypothetical protein 981560..982258 Streptococcus pneumoniae G54 6480283 YP_002037733.1 CDS rplU NC_011072.1 982570 982761 D identified by match to protein family HMM PF00829; match to protein family HMM TIGR00061; 50S ribosomal protein L21 982570..982761 Streptococcus pneumoniae G54 6479137 YP_002037734.1 CDS SPG_1024 NC_011072.1 982777 983121 D identified by match to protein family HMM PF04327; hypothetical protein 982777..983121 Streptococcus pneumoniae G54 6478864 YP_002037735.1 CDS rpmA NC_011072.1 983138 983431 D involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 983138..983431 Streptococcus pneumoniae G54 6480428 YP_002037736.1 CDS SPG_1026 NC_011072.1 983636 983842 R hypothetical protein complement(983636..983842) Streptococcus pneumoniae G54 6479296 YP_002037737.1 CDS SPG_1027 NC_011072.1 983814 983939 R hypothetical protein complement(983814..983939) Streptococcus pneumoniae G54 6478841 YP_002037738.1 CDS mreA NC_011072.1 984277 985194 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 984277..985194 Streptococcus pneumoniae G54 6479331 YP_002037739.1 CDS SPG_1029 NC_011072.1 985287 986135 R identified by match to protein family HMM PF02588; hypothetical protein complement(985287..986135) Streptococcus pneumoniae G54 6479406 YP_002037740.1 CDS SPG_1030 NC_011072.1 986277 987116 D identified by glimmer; putative; hypothetical protein 986277..987116 Streptococcus pneumoniae G54 6479500 YP_002037741.1 CDS hup NC_011072.1 987222 987497 D identified by match to protein family HMM PF00216; DNA-binding protein HU 987222..987497 Streptococcus pneumoniae G54 6479601 YP_002037742.1 CDS SPG_1032 NC_011072.1 987922 989823 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 987922..989823 Streptococcus pneumoniae G54 6480486 YP_002037743.1 CDS SPG_1033 NC_011072.1 989826 990689 D identified by match to protein family HMM TIGR01716; transcriptional activator MutR 989826..990689 Streptococcus pneumoniae G54 6479130 YP_002037744.1 CDS SPG_1034 NC_011072.1 990769 991947 D identified by match to protein family HMM PF07690; major facilitator family transporter 990769..991947 Streptococcus pneumoniae G54 6479797 YP_002037745.1 CDS ligA NC_011072.1 992040 993998 D this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 992040..993998 Streptococcus pneumoniae G54 6480652 YP_002037746.1 CDS SPG_1036 NC_011072.1 994110 996206 D contains potential frameshift; identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02104; thermostable pullulanase 994110..996206 Streptococcus pneumoniae G54 6479469 YP_002037747.1 CDS SPG_1037 NC_011072.1 996262 996390 D contains potential frameshift; thermostable pullulanase 996262..996390 Streptococcus pneumoniae G54 6479650 YP_002037748.1 CDS SPG_1038 NC_011072.1 996935 998359 D identified by match to protein family HMM PF00171; NADP-dependent glyceraldehyde-3-phosphate dehydrogenase 996935..998359 Streptococcus pneumoniae G54 6479190 YP_002037749.1 CDS glgB NC_011072.1 998735 1000663 D catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 998735..1000663 Streptococcus pneumoniae G54 6480080 YP_002037750.1 CDS glgC NC_011072.1 1000653 1001795 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1000653..1001795 Streptococcus pneumoniae G54 6478921 YP_002037751.1 CDS glgD NC_011072.1 1001785 1002924 D Spatafora,G.A. 1992 Inf.& Imm.; identified by match to protein family HMM PF00483; match to protein family HMM TIGR02092; glucose-1-phosphate adenylyltransferase subunit GlgD 1001785..1002924 Streptococcus pneumoniae G54 6480089 YP_002037752.1 CDS glgA NC_011072.1 1002921 1004354 D catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 1002921..1004354 Streptococcus pneumoniae G54 6480317 YP_002037753.1 CDS SPG_1043 NC_011072.1 1004413 1004784 D phosphoserine phosphatase 1004413..1004784 Streptococcus pneumoniae G54 6478948 YP_002037754.1 CDS SPG_1044 NC_011072.1 1004900 1005058 D hypothetical protein 1004900..1005058 Streptococcus pneumoniae G54 6479607 YP_002037755.1 CDS SPG_1046 NC_011072.1 1005067 1006182 D identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase 1005067..1006182 Streptococcus pneumoniae G54 6479303 YP_002037756.1 CDS SPG_1045 NC_011072.1 1006179 1006625 R identified by match to protein family HMM PF07997; hypothetical protein complement(1006179..1006625) Streptococcus pneumoniae G54 6480212 YP_002037757.1 CDS eno NC_011072.1 1006789 1008093 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1006789..1008093 Streptococcus pneumoniae G54 6480472 YP_002037758.1 CDS SPG_1048 NC_011072.1 1008231 1008677 R identified by match to protein family HMM PF00589; phage integrase family site-specific recombinase complement(1008231..1008677) Streptococcus pneumoniae G54 6479052 YP_002037759.1 CDS SPG_1049 NC_011072.1 1009094 1009423 R identified by match to protein family HMM PF01710; IS630-Spn1 transposase complement(1009094..1009423) Streptococcus pneumoniae G54 6480026 YP_002037760.1 CDS rexB NC_011072.1 1009949 1013224 D identified by match to protein family HMM TIGR02774; exonuclease RexB 1009949..1013224 Streptococcus pneumoniae G54 6480349 YP_002037761.1 CDS rexA NC_011072.1 1013221 1016871 D identified by match to protein family HMM PF00580; match to protein family HMM TIGR02785; exonuclease RexA 1013221..1016871 Streptococcus pneumoniae G54 6479678 YP_002037762.1 CDS SPG_1052 NC_011072.1 1017266 1018444 D hypothetical protein 1017266..1018444 Streptococcus pneumoniae G54 6478773 YP_002037763.1 CDS igA NC_011072.1 1018653 1024490 D identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM PF07581; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; immunoglobulin A1 protease 1018653..1024490 Streptococcus pneumoniae G54 6478876 YP_002037764.1 CDS zmpD NC_011072.1 1024534 1029771 D identified by match to protein family HMM PF00746; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM TIGR01167; zinc metalloprotease ZmpD 1024534..1029771 Streptococcus pneumoniae G54 6480369 YP_002037765.1 CDS SPG_1055 NC_011072.1 1029938 1031284 D identified by match to protein family HMM PF01609; IS1380-Spn1 transposase 1029938..1031284 Streptococcus pneumoniae G54 6479637 YP_002037766.1 CDS SPG_1056 NC_011072.1 1031470 1031631 R identified by glimmer; putative; hypothetical protein complement(1031470..1031631) Streptococcus pneumoniae G54 6479547 YP_002037767.1 CDS rbgA NC_011072.1 1031699 1032550 D essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1031699..1032550 Streptococcus pneumoniae G54 6478872 YP_002037768.1 CDS rnhB NC_011072.1 1032537 1033316 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1032537..1033316 Streptococcus pneumoniae G54 6479193 YP_002037769.1 CDS SPG_1059 NC_011072.1 1033332 1034882 D identified by match to protein family HMM PF00654; match to protein family HMM PF02080; voltage-gated chloride channel family protein 1033332..1034882 Streptococcus pneumoniae G54 6480312 YP_002037770.1 CDS xerS NC_011072.1 1035466 1036536 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1035466..1036536 Streptococcus pneumoniae G54 6479503 YP_002037771.1 CDS lplA NC_011072.1 1036603 1037592 R Morris,T.W. 1994 Journ.Biol.Chem.; identified by match to protein family HMM PF03099; match to protein family HMM TIGR00545; lipoate protein ligase A complement(1036603..1037592) Streptococcus pneumoniae G54 6479064 YP_002037772.1 CDS lpdA NC_011072.1 1037656 1039359 R identified by match to protein family HMM PF00070; match to protein family HMM PF00364; match to protein family HMM PF01134; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350; dihydrolipoyl dehydrogenase complement(1037656..1039359) Streptococcus pneumoniae G54 6480186 YP_002037773.1 CDS SPG_1063 NC_011072.1 1039405 1040448 R unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain; dihydrolipoamide acetyltransferase complement(1039405..1040448) Streptococcus pneumoniae G54 6479279 YP_002037774.1 CDS SPG_1064 NC_011072.1 1040666 1041658 R identified by match to protein family HMM PF02779; match to protein family HMM PF02780; acetoin dehydrogenase E1 component subunit beta complement(1040666..1041658) Streptococcus pneumoniae G54 6479667 YP_002037775.1 CDS SPG_1065 NC_011072.1 1041674 1042642 R identified by match to protein family HMM PF00676; TPP-dependent acetoin dehydrogenase subunit alpha complement(1041674..1042642) Streptococcus pneumoniae G54 6478839 YP_002037776.1 CDS SPG_1066 NC_011072.1 1042796 1044157 R identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; MATE efflux family protein complement(1042796..1044157) Streptococcus pneumoniae G54 6480757 YP_002037777.1 CDS pyrC NC_011072.1 1044442 1045710 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1044442..1045710) Streptococcus pneumoniae G54 6480563 YP_002037778.1 CDS mutX NC_011072.1 1045723 1046187 R identified by match to protein family HMM PF00293; mutator mutT protein complement(1045723..1046187) Streptococcus pneumoniae G54 6480061 YP_002037779.1 CDS SPG_1069 NC_011072.1 1046197 1046850 R Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase complement(1046197..1046850) Streptococcus pneumoniae G54 6480239 YP_002037780.1 CDS SPG_1070 NC_011072.1 1046986 1047588 R hypothetical protein complement(1046986..1047588) Streptococcus pneumoniae G54 6480137 YP_002037781.1 CDS SPG_1071 NC_011072.1 1047646 1048359 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; match to protein family HMM TIGR02254; haloacid dehalogenase-like hydrolase complement(1047646..1048359) Streptococcus pneumoniae G54 6479967 YP_002037782.1 CDS SPG_1072 NC_011072.1 1048756 1048986 R identified by match to protein family HMM PF03610; PTS system transporter subunit IIA complement(1048756..1048986) Streptococcus pneumoniae G54 6479166 YP_002037783.1 CDS phtA/B NC_011072.1 1049408 1051930 R Adamou JE, Infect Immun. 2001 Feb;69(2):949-58. c; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; histidine triad protein PhtA/B complement(1049408..1051930) Streptococcus pneumoniae G54 6479992 YP_002037784.1 CDS ptsI NC_011072.1 1052183 1053916 R identified by match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR01417; phosphoenolpyruvate-protein phosphotransferase complement(1052183..1053916) Streptococcus pneumoniae G54 6479576 YP_002037785.1 CDS ptsH NC_011072.1 1053922 1054185 R identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; phosphocarrier protein HPr complement(1053922..1054185) Streptococcus pneumoniae G54 6478930 YP_002037786.1 CDS nrdH NC_011072.1 1054536 1054754 D identified by match to protein family HMM PF00462; match to protein family HMM TIGR02194; NrdH-redoxin 1054536..1054754 Streptococcus pneumoniae G54 6479324 YP_002037787.1 CDS nrdA NC_011072.1 1054835 1056994 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1054835..1056994 Streptococcus pneumoniae G54 6478973 YP_002037788.1 CDS nrdF NC_011072.1 1057182 1058144 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1057182..1058144 Streptococcus pneumoniae G54 6478889 YP_002037789.1 CDS SPG_1079 NC_011072.1 1058326 1059087 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; lactose phosphotransferase system repressor 1058326..1059087 Streptococcus pneumoniae G54 6479925 YP_002037790.1 CDS SPG_1080 NC_011072.1 1059366 1059545 R hypothetical protein complement(1059366..1059545) Streptococcus pneumoniae G54 6479934 YP_002037791.1 CDS lacG NC_011072.1 1059668 1061074 R catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase complement(1059668..1061074) Streptococcus pneumoniae G54 6479739 YP_002037792.1 CDS SPG_1082 NC_011072.1 1061289 1062980 R identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00394; match to protein family HMM TIGR00410; match to protein family HMM TIGR00853; PTS system transporter subunit IIBC complement(1061289..1062980) Streptococcus pneumoniae G54 6479996 YP_002037793.1 CDS SPG_1083 NC_011072.1 1062980 1063297 R identified by match to protein family HMM PF02255; match to protein family HMM TIGR00823; PTS system transporter subunit IIA complement(1062980..1063297) Streptococcus pneumoniae G54 6478769 YP_002037794.1 CDS SPG_1084 NC_011072.1 1063333 1064169 R identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator LacT complement(1063333..1064169) Streptococcus pneumoniae G54 6480109 YP_002037795.1 CDS lacD NC_011072.1 1064403 1065383 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase complement(1064403..1065383) Streptococcus pneumoniae G54 6479088 YP_002037796.1 CDS lacC NC_011072.1 1065385 1066314 R catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase complement(1065385..1066314) Streptococcus pneumoniae G54 6478686 YP_002037797.1 CDS lacB NC_011072.1 1066325 1066840 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB complement(1066325..1066840) Streptococcus pneumoniae G54 6480347 YP_002037798.1 CDS lacA NC_011072.1 1066871 1067296 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA complement(1066871..1067296) Streptococcus pneumoniae G54 6480700 YP_002037799.1 CDS SPG_1089 NC_011072.1 1067453 1067797 R identified by glimmer; putative; hypothetical protein complement(1067453..1067797) Streptococcus pneumoniae G54 6478842 YP_002037800.1 CDS SPG_1090 NC_011072.1 1068007 1068354 R transposase complement(1068007..1068354) Streptococcus pneumoniae G54 6480108 YP_002037801.1 CDS SPG_1091 NC_011072.1 1068371 1068769 R transposase complement(1068371..1068769) Streptococcus pneumoniae G54 6480770 YP_002037802.1 CDS SPG_1092 NC_011072.1 1068777 1069079 R PTS system transporter subunit IIB complement(1068777..1069079) Streptococcus pneumoniae G54 6479175 YP_002037803.1 CDS SPG_1093 NC_011072.1 1069117 1069503 R PTS system transporter subunit IIA complement(1069117..1069503) Streptococcus pneumoniae G54 6479328 YP_002037804.1 CDS SPG_1094 NC_011072.1 1070140 1071963 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(1070140..1071963) Streptococcus pneumoniae G54 6480437 YP_002037805.1 CDS SPG_1095 NC_011072.1 1072042 1072770 R identified by match to protein family HMM PF00149; Ser/Thr protein phosphatase family protein complement(1072042..1072770) Streptococcus pneumoniae G54 6480623 YP_002037806.1 CDS recN NC_011072.1 1072772 1074439 R identified by match to protein family HMM PF02463; match to protein family HMM TIGR00634; DNA repair protein RecN complement(1072772..1074439) Streptococcus pneumoniae G54 6479402 YP_002037807.1 CDS SPG_1097 NC_011072.1 1074446 1074877 R identified by match to protein family HMM PF01316; match to protein family HMM PF02863; transcriptional repressor complement(1074446..1074877) Streptococcus pneumoniae G54 6480290 YP_002037808.1 CDS SPG_1098 NC_011072.1 1074870 1075685 R identified by match to protein family HMM PF01479; match to protein family HMM PF01728; match to protein family HMM TIGR00478; hemolysin A complement(1074870..1075685) Streptococcus pneumoniae G54 6480669 YP_002037809.1 CDS ispA NC_011072.1 1075678 1076553 R identified by match to protein family HMM PF00348; geranyltranstransferase complement(1075678..1076553) Streptococcus pneumoniae G54 6480678 YP_002037810.1 CDS xseB NC_011072.1 1076550 1076762 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(1076550..1076762) Streptococcus pneumoniae G54 6478873 YP_002037811.1 CDS xseA NC_011072.1 1076740 1078080 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(1076740..1078080) Streptococcus pneumoniae G54 6480522 YP_002037812.1 CDS udk NC_011072.1 1078208 1078846 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(1078208..1078846) Streptococcus pneumoniae G54 6479473 YP_002037813.1 CDS SPG_1103 NC_011072.1 1078954 1079256 R hypothetical protein complement(1078954..1079256) Streptococcus pneumoniae G54 6480556 YP_002037814.1 CDS truB NC_011072.1 1079497 1080375 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(1079497..1080375) Streptococcus pneumoniae G54 6478830 YP_002037815.1 CDS SPG_1105 NC_011072.1 1080476 1083661 R hypothetical protein complement(1080476..1083661) Streptococcus pneumoniae G54 6480539 YP_002037816.1 CDS SPG_1106 NC_011072.1 1083673 1084947 R hypothetical protein complement(1083673..1084947) Streptococcus pneumoniae G54 6479036 YP_002037817.1 CDS SPG_1107 NC_011072.1 1085043 1086158 R identified by match to protein family HMM PF01041; match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326; O-acetylhomoserine sulfhydrylase complement(1085043..1086158) Streptococcus pneumoniae G54 6478896 YP_002037818.1 CDS SPG_1108 NC_011072.1 1086180 1086302 R hypothetical protein complement(1086180..1086302) Streptococcus pneumoniae G54 6480292 YP_002037819.1 CDS SPG_1109 NC_011072.1 1086450 1087247 R identified by match to protein family HMM PF01226; FNT family transporter complement(1086450..1087247) Streptococcus pneumoniae G54 6478728 YP_002037820.1 CDS SPG_1110 NC_011072.1 1087491 1088234 R identified by match to protein family HMM PF04203; match to protein family HMM TIGR01076; sortase family protein complement(1087491..1088234) Streptococcus pneumoniae G54 6479718 YP_002037821.1 CDS gyrA NC_011072.1 1088234 1090702 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(1088234..1090702) Streptococcus pneumoniae G54 6479317 YP_002037822.1 CDS ldh NC_011072.1 1090896 1091882 D Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1090896..1091882 Streptococcus pneumoniae G54 6480459 YP_002037823.1 CDS SPG_1113 NC_011072.1 1092171 1092914 R identified by match to protein family HMM PF00520; match to protein family HMM PF07885; transporter, cation channel family complement(1092171..1092914) Streptococcus pneumoniae G54 6478732 YP_002037824.1 CDS SPG_1114 NC_011072.1 1092961 1093215 R identified by glimmer; putative; hypothetical protein complement(1092961..1093215) Streptococcus pneumoniae G54 6480508 YP_002037825.1 CDS SPG_1115 NC_011072.1 1093217 1093459 R hypothetical protein complement(1093217..1093459) Streptococcus pneumoniae G54 6479665 YP_002037826.1 CDS SPG_1116 NC_011072.1 1093550 1094359 R identified by match to protein family HMM PF00753; VicX protein complement(1093550..1094359) Streptococcus pneumoniae G54 6480707 YP_002037827.1 CDS micB NC_011072.1 1094361 1095710 R identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM TIGR00229; histidine kinase complement(1094361..1095710) Streptococcus pneumoniae G54 6479595 YP_002037828.1 CDS micA NC_011072.1 1095703 1096407 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator complement(1095703..1096407) Streptococcus pneumoniae G54 6479167 YP_002037829.1 CDS mutY NC_011072.1 1096463 1097638 R identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01084; A/G-specific adenine glycosylase complement(1096463..1097638) Streptococcus pneumoniae G54 6479603 YP_002037830.1 CDS fhs NC_011072.1 1097966 1099636 R catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase complement(1097966..1099636) Streptococcus pneumoniae G54 6479244 YP_002037831.1 CDS coaB NC_011072.1 1099866 1100555 D identified by match to protein family HMM PF04127; match to protein family HMM TIGR02114; phosphopantothenate--cysteine ligase 1099866..1100555 Streptococcus pneumoniae G54 6480425 YP_002037832.1 CDS coaC NC_011072.1 1100567 1101118 D decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 1100567..1101118 Streptococcus pneumoniae G54 6480303 YP_002037833.1 CDS SPG_1123 NC_011072.1 1101102 1101665 D hypothetical protein 1101102..1101665 Streptococcus pneumoniae G54 6479290 YP_002037834.1 CDS SPG_1124 NC_011072.1 1101948 1102475 D hypothetical protein 1101948..1102475 Streptococcus pneumoniae G54 6480078 YP_002037835.1 CDS SPG_1126 NC_011072.1 1102487 1103002 D identified by match to protein family HMM PF02829; match to protein family HMM PF08279; transcriptional regulator 1102487..1103002 Streptococcus pneumoniae G54 6479270 YP_002037836.1 CDS SPG_1125 NC_011072.1 1102999 1103466 R identified by match to protein family HMM PF00293; mutT/nudix family protein complement(1102999..1103466) Streptococcus pneumoniae G54 6478877 YP_002037837.1 CDS SPG_1127 NC_011072.1 1103540 1104028 R identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1103540..1104028) Streptococcus pneumoniae G54 6480562 YP_002037838.1 CDS SPG_1128 NC_011072.1 1103994 1104557 R GNAT family acetyltransferase complement(1103994..1104557) Streptococcus pneumoniae G54 6479045 YP_002037839.1 CDS uvrB NC_011072.1 1104567 1106555 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B complement(1104567..1106555) Streptococcus pneumoniae G54 6480467 YP_002037840.1 CDS SPG_1130 NC_011072.1 1106632 1107585 R identified by match to protein family HMM PF02517; CAAX amino terminal protease family complement(1106632..1107585) Streptococcus pneumoniae G54 6479534 YP_002037841.1 CDS glnP NC_011072.1 1107758 1109923 D identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; ABC transporter amino acid-binding protein/permease 1107758..1109923 Streptococcus pneumoniae G54 6479830 YP_002037842.1 CDS glnQ NC_011072.1 1109923 1110663 D identified by match to protein family HMM PF00005; glutamine ABC transporter ATP-binding protein 1109923..1110663 Streptococcus pneumoniae G54 6479681 YP_002037843.1 CDS zwf NC_011072.1 1110812 1112299 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1110812..1112299 Streptococcus pneumoniae G54 6478710 YP_002037844.1 CDS ftsY NC_011072.1 1112345 1113622 R identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM TIGR00064; signal recognition particle-docking protein FtsY complement(1112345..1113622) Streptococcus pneumoniae G54 6480730 YP_002037845.1 CDS SPG_1135 NC_011072.1 1113626 1114444 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1113626..1114444) Streptococcus pneumoniae G54 6479162 YP_002037846.1 CDS SPG_1136 NC_011072.1 1114444 1115238 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1114444..1115238) Streptococcus pneumoniae G54 6479283 YP_002037847.1 CDS SPG_1137 NC_011072.1 1115235 1118774 R identified by match to protein family HMM PF02463; match to protein family HMM PF06470; chromosome segregation protein smc complement(1115235..1118774) Streptococcus pneumoniae G54 6480471 YP_002037848.1 CDS rnc NC_011072.1 1118765 1119463 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(1118765..1119463) Streptococcus pneumoniae G54 6480464 YP_002037849.1 CDS guaC NC_011072.1 1119781 1120767 R identified by match to protein family HMM PF00478; match to protein family HMM TIGR01306; guanosine 5'-monophosphate oxidoreductase complement(1119781..1120767) Streptococcus pneumoniae G54 6480426 YP_002037850.1 CDS SPG_1141 NC_011072.1 1120942 1122168 R hypothetical protein complement(1120942..1122168) Streptococcus pneumoniae G54 6479152 YP_002037851.1 CDS SPG_1142 NC_011072.1 1122245 1123837 R putative endonuclease complement(1122245..1123837) Streptococcus pneumoniae G54 6479359 YP_002037852.1 CDS SPG_1143 NC_011072.1 1123871 1124176 R putative endonuclease complement(1123871..1124176) Streptococcus pneumoniae G54 6480535 YP_002037853.1 CDS SPG_1144 NC_011072.1 1124342 1124503 R hypothetical protein complement(1124342..1124503) Streptococcus pneumoniae G54 6480262 YP_002037854.1 CDS SPG_1145 NC_011072.1 1124493 1124666 R hypothetical protein complement(1124493..1124666) Streptococcus pneumoniae G54 6479291 YP_002037855.1 CDS SPG_1146 NC_011072.1 1124766 1124909 R hypothetical protein complement(1124766..1124909) Streptococcus pneumoniae G54 6479596 YP_002037856.1 CDS SPG_1147 NC_011072.1 1125128 1125487 R hypothetical protein complement(1125128..1125487) Streptococcus pneumoniae G54 6479871 YP_002037857.1 CDS SPG_1148 NC_011072.1 1125491 1125760 R identified by match to protein family HMM PF06961; hypothetical protein complement(1125491..1125760) Streptococcus pneumoniae G54 6480123 YP_002037858.1 CDS SPG_1149 NC_011072.1 1125757 1126548 R identified by similarity to SP:Q8DPJ4; match to protein family HMM PF00180; match to protein family HMM TIGR00169; 3-isopropylmalate dehydrogenase complement(1125757..1126548) Streptococcus pneumoniae G54 6478658 YP_002037859.1 CDS SPG_1150 NC_011072.1 1126639 1126794 R 3-isopropylmalate dehydrogenase complement(1126639..1126794) Streptococcus pneumoniae G54 6479133 YP_002037860.1 CDS SPG_1151 NC_011072.1 1126806 1127900 R identified by match to protein family HMM PF00682; match to protein family HMM PF08502; 2-isopropylmalate synthase complement(1126806..1127900) Streptococcus pneumoniae G54 6479016 YP_002037861.1 CDS SPG_1152 NC_011072.1 1127919 1128575 R identified by match to protein family HMM PF04237; hypothetical protein complement(1127919..1128575) Streptococcus pneumoniae G54 6479265 YP_002037863.1 CDS SPG_1154 NC_011072.1 1129112 1129252 R contains potential frameshift; copper homeostasis protein CutC complement(1129112..1129252) Streptococcus pneumoniae G54 6478962 YP_002037864.1 CDS SPG_1155 NC_011072.1 1129345 1129704 R identified by match to protein family HMM PF04304; hypothetical protein complement(1129345..1129704) Streptococcus pneumoniae G54 6479999 YP_002037865.1 CDS topA NC_011072.1 1129810 1131897 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(1129810..1131897) Streptococcus pneumoniae G54 6480675 YP_002037866.1 CDS SPG_1157 NC_011072.1 1132064 1133083 R identified by match to protein family HMM PF04087; hypothetical protein complement(1132064..1133083) Streptococcus pneumoniae G54 6479053 YP_002037867.1 CDS SPG_1158 NC_011072.1 1133007 1133141 D identified by glimmer; putative; hypothetical protein 1133007..1133141 Streptococcus pneumoniae G54 6479942 YP_002037868.1 CDS SPG_1159 NC_011072.1 1133651 1133893 R identified by glimmer; putative; hypothetical protein complement(1133651..1133893) Streptococcus pneumoniae G54 6480097 YP_002037869.1 CDS dprA NC_011072.1 1133991 1134839 R DNA processing chain A: Also known as smf protein (name of uncharacterized protein in E. coli); identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732; DNA processing Smf protein complement(1133991..1134839) Streptococcus pneumoniae G54 6478648 YP_002037870.1 CDS SPG_1161 NC_011072.1 1134925 1135614 R identified by match to protein family HMM PF00483; CTP:phosphocholine cytidylyltransferase complement(1134925..1135614) Streptococcus pneumoniae G54 6480121 YP_002037871.1 CDS SPG_1162 NC_011072.1 1135626 1136504 R identified by match to protein family HMM PF00892; LicB protein complement(1135626..1136504) Streptococcus pneumoniae G54 6479066 YP_002037872.1 CDS SPG_1163 NC_011072.1 1136494 1137363 R identified by match to protein family HMM PF01633; match to protein family HMM PF01636; choline kinase complement(1136494..1137363) Streptococcus pneumoniae G54 6480639 YP_002037873.1 CDS SPG_1164 NC_011072.1 1137380 1138402 R identified by match to protein family HMM PF08240; alcohol dehydrogenase complement(1137380..1138402) Streptococcus pneumoniae G54 6479976 YP_002037874.1 CDS ispD NC_011072.1 1138407 1139114 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(1138407..1139114) Streptococcus pneumoniae G54 6479371 YP_002037875.1 CDS SPG_1166 NC_011072.1 1139450 1140937 D identified by match to protein family HMM PF01943; polysaccharide biosynthesis protein 1139450..1140937 Streptococcus pneumoniae G54 6479655 YP_002037876.1 CDS SPG_1167 NC_011072.1 1140947 1141750 D identified by match to protein family HMM PF04991; phosphotransferase LicD1 1140947..1141750 Streptococcus pneumoniae G54 6479572 YP_002037877.1 CDS SPG_1168 NC_011072.1 1141752 1142561 D identified by match to protein family HMM PF04991; phosphotransferase LicD2 1141752..1142561 Streptococcus pneumoniae G54 6480804 YP_002037878.1 CDS carB NC_011072.1 1142837 1146013 R four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit complement(1142837..1146013) Streptococcus pneumoniae G54 6479397 YP_002037879.1 CDS carA NC_011072.1 1146326 1147405 R catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit complement(1146326..1147405) Streptococcus pneumoniae G54 6479426 YP_002037880.1 CDS pyrB NC_011072.1 1147455 1148378 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit complement(1147455..1148378) Streptococcus pneumoniae G54 6479617 YP_002037881.1 CDS pyrR NC_011072.1 1148397 1148918 R regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase complement(1148397..1148918) Streptococcus pneumoniae G54 6480023 YP_002037882.1 CDS nth NC_011072.1 1149128 1149757 R identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01083; endonuclease III complement(1149128..1149757) Streptococcus pneumoniae G54 6480740 YP_002037883.1 CDS SPG_1174 NC_011072.1 1149757 1150299 R identified by match to protein family HMM PF02620; hypothetical protein complement(1149757..1150299) Streptococcus pneumoniae G54 6479431 YP_002037884.1 CDS SPG_1175 NC_011072.1 1150469 1150609 D identified by glimmer; putative; hypothetical protein 1150469..1150609 Streptococcus pneumoniae G54 6480825 YP_002037885.1 CDS SPG_1176 NC_011072.1 1151024 1152583 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1151024..1152583 Streptococcus pneumoniae G54 6478659 YP_002037886.1 CDS SPG_1177 NC_011072.1 1152732 1153631 R putative metalloprotease; heat shock protein HtpX complement(1152732..1153631) Streptococcus pneumoniae G54 6480609 YP_002037887.1 CDS SPG_1178 NC_011072.1 1153633 1154193 R identified by match to protein family HMM PF04011; cytoplasmic membrane protein complement(1153633..1154193) Streptococcus pneumoniae G54 6479711 YP_002037888.1 CDS gidB NC_011072.1 1154287 1155000 D glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1154287..1155000 Streptococcus pneumoniae G54 6478813 YP_002037889.1 CDS pyrP NC_011072.1 1155254 1156537 D identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; uracil permease (pyrP) 1155254..1156537 Streptococcus pneumoniae G54 6478826 YP_002037890.1 CDS SPG_1181 NC_011072.1 1156732 1158303 R identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959; signal recognition particle protein complement(1156732..1158303) Streptococcus pneumoniae G54 6478671 YP_002037891.1 CDS SPG_1182 NC_011072.1 1158315 1158647 R identified by glimmer; putative; putative DNA-binding protein complement(1158315..1158647) Streptococcus pneumoniae G54 6478675 YP_002037892.1 CDS SPG_1183 NC_011072.1 1158738 1159115 R identified by match to protein family HMM PF09148; hypothetical protein complement(1158738..1159115) Streptococcus pneumoniae G54 6479913 YP_002037893.1 CDS SPG_1184 NC_011072.1 1159187 1160491 D identified by match to protein family HMM PF01966; hypothetical protein 1159187..1160491 Streptococcus pneumoniae G54 6480309 YP_002037894.1 CDS SPG_1185 NC_011072.1 1160504 1161310 D identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 1160504..1161310 Streptococcus pneumoniae G54 6480433 YP_002037895.1 CDS rplS NC_011072.1 1161480 1161827 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(1161480..1161827) Streptococcus pneumoniae G54 6480159 YP_002037896.1 CDS SPG_1188 NC_011072.1 1161946 1162275 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1161946..1162275) Streptococcus pneumoniae G54 6480182 YP_002037897.1 CDS SPG_1189 NC_011072.1 1162269 1162643 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1162269..1162643) Streptococcus pneumoniae G54 6479412 YP_002037898.1 CDS SPG_1190 NC_011072.1 1162640 1162906 R identified by match to protein family HMM PF01817; match to protein family HMM TIGR01805; hypothetical protein complement(1162640..1162906) Streptococcus pneumoniae G54 6478835 YP_002037899.1 CDS SPG_1191 NC_011072.1 1163022 1163465 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(1163022..1163465) Streptococcus pneumoniae G54 6479802 YP_002037900.1 CDS SPG_1192 NC_011072.1 1163569 1164504 D identified by match to protein family HMM PF01368; hypothetical protein 1163569..1164504 Streptococcus pneumoniae G54 6480491 YP_002037901.1 CDS rpmE2 NC_011072.1 1164600 1164842 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 1164600..1164842 Streptococcus pneumoniae G54 6480702 YP_002037902.1 CDS SPG_1194 NC_011072.1 1164899 1165117 R identified by glimmer; putative; hypothetical protein complement(1164899..1165117) Streptococcus pneumoniae G54 6480127 YP_002037903.1 CDS SPG_1195 NC_011072.1 1165114 1165275 R transposase complement(1165114..1165275) Streptococcus pneumoniae G54 6478964 YP_002037904.1 CDS SPG_1196 NC_011072.1 1165425 1165676 R IS630-SpnII transposase complement(1165425..1165676) Streptococcus pneumoniae G54 6478897 YP_002037905.1 CDS gdhA NC_011072.1 1166202 1167548 D converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1166202..1167548 Streptococcus pneumoniae G54 6480746 YP_002037906.1 CDS SPG_1198 NC_011072.1 1168054 1168224 R hypothetical protein complement(1168054..1168224) Streptococcus pneumoniae G54 6479876 YP_002037907.1 CDS SPG_1199 NC_011072.1 1168237 1168683 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1168237..1168683) Streptococcus pneumoniae G54 6479684 YP_002037908.1 CDS SPG_1200 NC_011072.1 1168873 1169220 R transposase complement(1168873..1169220) Streptococcus pneumoniae G54 6478721 YP_002037909.1 CDS SPG_1201 NC_011072.1 1169237 1169635 R transposase complement(1169237..1169635) Streptococcus pneumoniae G54 6480072 YP_002037910.1 CDS SPG_1202 NC_011072.1 1169728 1169886 R IS66-Spn1 transposase complement(1169728..1169886) Streptococcus pneumoniae G54 6479028 YP_002037911.1 CDS SPG_1203 NC_011072.1 1170149 1170319 R IS66-Spn1 transposase complement(1170149..1170319) Streptococcus pneumoniae G54 6479245 YP_002037912.1 CDS SPG_1204 NC_011072.1 1170481 1170792 R IS66-Spn1 transposase complement(1170481..1170792) Streptococcus pneumoniae G54 6480010 YP_002037913.1 CDS SPG_1205 NC_011072.1 1170954 1171106 D IS630-SpnII transposase 1170954..1171106 Streptococcus pneumoniae G54 6479380 YP_002037914.1 CDS SPG_1206 NC_011072.1 1171375 1171698 R identified by match to protein family HMM PF05717; IS66-Spn1 transposase complement(1171375..1171698) Streptococcus pneumoniae G54 6478971 YP_002037915.1 CDS SPG_1207 NC_011072.1 1171679 1171918 R IS66-Spn1 transposase complement(1171679..1171918) Streptococcus pneumoniae G54 6479811 YP_002037916.1 CDS ntpD NC_011072.1 1172137 1172748 R produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit D complement(1172137..1172748) Streptococcus pneumoniae G54 6479288 YP_002037917.1 CDS ntpB NC_011072.1 1172771 1174156 R produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit B complement(1172771..1174156) Streptococcus pneumoniae G54 6479508 YP_002037918.1 CDS ntpA NC_011072.1 1174157 1175932 R produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit A complement(1174157..1175932) Streptococcus pneumoniae G54 6480551 YP_002037919.1 CDS ntpG NC_011072.1 1175995 1176315 R produces ATP from ADP in the presence of a proton gradient across the membrane; the F subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit F complement(1175995..1176315) Streptococcus pneumoniae G54 6480315 YP_002037920.1 CDS ntpC NC_011072.1 1176305 1177312 R Takase, K. (1994) Journ. Biol. Chem. 269(15) 11037-11044; identified by match to protein family HMM PF01992; V-type sodium ATP synthase subunit C complement(1176305..1177312) Streptococcus pneumoniae G54 6480148 YP_002037921.1 CDS ntpE NC_011072.1 1177377 1177958 R Takase, K. (1994) Journ. Biol. Chem. 269(15) 11037-11044; V-type sodium ATP synthase subunit E complement(1177377..1177958) Streptococcus pneumoniae G54 6480452 YP_002037922.1 CDS ntpK NC_011072.1 1177992 1178468 R produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits; V-type ATP synthase subunit K complement(1177992..1178468) Streptococcus pneumoniae G54 6480750 YP_002037923.1 CDS ntpI NC_011072.1 1178484 1180475 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I is part of the membrane proton channel.; V-type ATP synthase subunit I complement(1178484..1180475) Streptococcus pneumoniae G54 6480271 YP_002037924.1 CDS SPG_1216 NC_011072.1 1180465 1180788 R identified by glimmer; putative; hypothetical protein complement(1180465..1180788) Streptococcus pneumoniae G54 6479393 YP_002037925.1 CDS SPG_1217 NC_011072.1 1180813 1181703 R identified by match to protein family HMM PF00480; ROK family protein complement(1180813..1181703) Streptococcus pneumoniae G54 6479231 YP_002037926.1 CDS SPG_1218 NC_011072.1 1181860 1182969 R identified by similarity to RF:ZP_00403965.1; match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; match to protein family HMM PF03447; hypothetical protein complement(1181860..1182969) Streptococcus pneumoniae G54 6479348 YP_002037927.1 CDS nanC NC_011072.1 1183009 1185231 R identified by match to protein family HMM PF02012; match to protein family HMM PF02973; neuraminidase C complement(1183009..1185231) Streptococcus pneumoniae G54 6478950 YP_002037928.1 CDS SPG_1220 NC_011072.1 1185233 1185691 R identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein complement(1185233..1185691) Streptococcus pneumoniae G54 6480645 YP_002037929.1 CDS SPG_1221 NC_011072.1 1185710 1187251 R identified by match to protein family HMM PF00474; match to protein family HMM TIGR00813; sodium symporter family protein complement(1185710..1187251) Streptococcus pneumoniae G54 6479446 YP_002037930.1 CDS SPG_1222 NC_011072.1 1187279 1188196 R identified by match to protein family HMM PF00701; dihydrodipicolinate synthetase family complement(1187279..1188196) Streptococcus pneumoniae G54 6480505 YP_002037931.1 CDS SPG_1223 NC_011072.1 1188221 1188922 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(1188221..1188922) Streptococcus pneumoniae G54 6480466 YP_002037932.1 CDS SPG_1224 NC_011072.1 1188927 1189736 R identified by match to protein family HMM PF01380; match to protein family HMM PF01418; RpiR family transcriptional regulator complement(1188927..1189736) Streptococcus pneumoniae G54 6479527 YP_002037933.1 CDS SPG_1225 NC_011072.1 1190136 1190723 R identified by match to protein family HMM PF02517; Tn5253 CAAX amino terminal protease family complement(1190136..1190723) Streptococcus pneumoniae G54 6479260 YP_002037934.1 CDS SPG_1226 NC_011072.1 1190850 1190966 R hypothetical protein complement(1190850..1190966) Streptococcus pneumoniae G54 6479751 YP_002037935.1 CDS SPG_1227 NC_011072.1 1190980 1191360 R Tn5253 hypothetical protein complement(1190980..1191360) Streptococcus pneumoniae G54 6479561 YP_002037936.1 CDS SPG_1228 NC_011072.1 1191353 1191676 R Tn5253 hypothetical protein complement(1191353..1191676) Streptococcus pneumoniae G54 6478929 YP_002037937.1 CDS SPG_1229 NC_011072.1 1191684 1191938 R identified by glimmer; putative; hypothetical protein complement(1191684..1191938) Streptococcus pneumoniae G54 6480427 YP_002037938.1 CDS SPG_1230 NC_011072.1 1191935 1192108 R hypothetical protein complement(1191935..1192108) Streptococcus pneumoniae G54 6480055 YP_002037939.1 CDS SPG_1231 NC_011072.1 1192417 1194336 R identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM PF03764; match to protein family HMM TIGR00231; tetracycline resistance protein TetM complement(1192417..1194336) Streptococcus pneumoniae G54 6480448 YP_002037940.1 CDS SPG_1232 NC_011072.1 1194713 1195630 R identified by similarity to RF:YP_133682.1; Tn5251 hypothetical protein complement(1194713..1195630) Streptococcus pneumoniae G54 6479003 YP_002037941.1 CDS SPG_1233 NC_011072.1 1195645 1196646 R identified by match to protein family HMM PF00877; Tn5251 lipoprotein NLP/P60 family complement(1195645..1196646) Streptococcus pneumoniae G54 6479955 YP_002037942.1 CDS SPG_1234 NC_011072.1 1196643 1198754 R Tn5251 membrane protein putative complement(1196643..1198754) Streptococcus pneumoniae G54 6478966 YP_002037943.1 CDS SPG_1235 NC_011072.1 1198823 1201270 R Tn5251 hypothetical protein complement(1198823..1201270) Streptococcus pneumoniae G54 6478834 YP_002037944.1 CDS SPG_1236 NC_011072.1 1201254 1201646 R Tn5251 hypothetical protein complement(1201254..1201646) Streptococcus pneumoniae G54 6478701 YP_002037945.1 CDS SPG_1237 NC_011072.1 1201735 1202232 R identified by match to protein family HMM PF07275; Tn5251 hypothetical protein complement(1201735..1202232) Streptococcus pneumoniae G54 6479731 YP_002037946.1 CDS SPG_1238 NC_011072.1 1202349 1202570 R Tn5251 hypothetical protein complement(1202349..1202570) Streptococcus pneumoniae G54 6478840 YP_002037947.1 CDS SPG_1239 NC_011072.1 1202750 1203397 D identified by match to protein family HMM PF01610; transposase 1202750..1203397 Streptococcus pneumoniae G54 6480565 YP_002037948.1 CDS SPG_1240 NC_011072.1 1203357 1203983 D identified by match to protein family HMM PF01610; transposase 1203357..1203983 Streptococcus pneumoniae G54 6479748 YP_002037949.1 CDS ermB NC_011072.1 1204240 1204977 R identified by match to protein family HMM PF00398; rRNA adenine N-6-methyltransferase ErmB complement(1204240..1204977) Streptococcus pneumoniae G54 6479254 YP_002037950.1 CDS SPG_1242 NC_011072.1 1205234 1206652 R identified by match to protein family HMM PF01381; match to protein family HMM PF02486; match to protein family HMM PF07764; Tn5251 transcriptional regulator Cro/CI family complement(1205234..1206652) Streptococcus pneumoniae G54 6479108 YP_002037951.1 CDS SPG_1243 NC_011072.1 1206830 1208215 R identified by match to protein family HMM PF01580; Tn5251 FtsK/SpoIIIE family protein complement(1206830..1208215) Streptococcus pneumoniae G54 6480116 YP_002037952.1 CDS SPG_1244 NC_011072.1 1208244 1208627 R identified by match to protein family HMM PF06125; Tn5251 hypothetical protein complement(1208244..1208627) Streptococcus pneumoniae G54 6480169 YP_002037953.1 CDS SPG_1245 NC_011072.1 1208646 1208960 R identified by match to protein family HMM PF06125; Tn5251 hypothetical protein complement(1208646..1208960) Streptococcus pneumoniae G54 6479306 YP_002037954.1 CDS SPG_1246 NC_011072.1 1209362 1209475 R identified by glimmer; putative; hypothetical protein complement(1209362..1209475) Streptococcus pneumoniae G54 6478996 YP_002037955.1 CDS SPG_1247 NC_011072.1 1209724 1210587 D identified by match to protein family HMM PF01381; putative transcriptional activator 1209724..1210587 Streptococcus pneumoniae G54 6480524 YP_002037956.1 CDS SPG_1248 NC_011072.1 1210692 1210940 R hypothetical protein complement(1210692..1210940) Streptococcus pneumoniae G54 6480451 YP_002037957.1 CDS SPG_1249 NC_011072.1 1211144 1211617 R relaxase complement(1211144..1211617) Streptococcus pneumoniae G54 6480070 YP_002037958.1 CDS SPG_1250 NC_011072.1 1211631 1212968 R identified by match to protein family HMM PF03432; Tn5253 relaxase complement(1211631..1212968) Streptococcus pneumoniae G54 6480020 YP_002037959.1 CDS SPG_1251 NC_011072.1 1212955 1213320 R identified by match to protein family HMM PF05713; Tn5253 hypothetical protein complement(1212955..1213320) Streptococcus pneumoniae G54 6479791 YP_002037960.1 CDS SPG_1252 NC_011072.1 1213325 1213681 R Tn5253 hypothetical protein complement(1213325..1213681) Streptococcus pneumoniae G54 6480444 YP_002037961.1 CDS SPG_1253 NC_011072.1 1214044 1215219 D identified by glimmer; putative; hypothetical protein 1214044..1215219 Streptococcus pneumoniae G54 6479884 YP_002037962.1 CDS SPG_1254 NC_011072.1 1215305 1217122 R identified by match to protein family HMM PF00580; ATP-dependent DNA helicase complement(1215305..1217122) Streptococcus pneumoniae G54 6478645 YP_002037963.1 CDS SPG_1255 NC_011072.1 1217109 1219178 R DNA helicase associated protein complement(1217109..1219178) Streptococcus pneumoniae G54 6479001 YP_002037964.1 CDS SPG_1257 NC_011072.1 1219829 1221079 D identified by glimmer; putative; hypothetical protein 1219829..1221079 Streptococcus pneumoniae G54 6480797 YP_002037965.1 CDS SPG_1256 NC_011072.1 1221076 1221648 R hypothetical protein complement(1221076..1221648) Streptococcus pneumoniae G54 6480068 YP_002037966.1 CDS SPG_1258 NC_011072.1 1221742 1222638 D identified by match to protein family HMM PF00589; match to protein family HMM PF02899; integrase 1221742..1222638 Streptococcus pneumoniae G54 6479866 YP_002037967.1 CDS SPG_1259 NC_011072.1 1223016 1223396 R Tn5253 hypothetical protein complement(1223016..1223396) Streptococcus pneumoniae G54 6479307 YP_002037968.1 CDS SPG_1260 NC_011072.1 1223457 1223597 D transposase 1223457..1223597 Streptococcus pneumoniae G54 6479849 YP_002037969.1 CDS SPG_1261 NC_011072.1 1223756 1223983 R identified by glimmer; putative; hypothetical protein complement(1223756..1223983) Streptococcus pneumoniae G54 6479939 YP_002037970.1 CDS SPG_1262 NC_011072.1 1223974 1224606 R identified by glimmer; putative; hypothetical protein complement(1223974..1224606) Streptococcus pneumoniae G54 6479200 YP_002037971.1 CDS SPG_1263 NC_011072.1 1224688 1224963 R Tn5253 hypothetical protein complement(1224688..1224963) Streptococcus pneumoniae G54 6478855 YP_002037972.1 CDS SPG_1264 NC_011072.1 1225001 1225384 R Tn5253 hypothetical protein complement(1225001..1225384) Streptococcus pneumoniae G54 6480390 YP_002037973.1 CDS SPG_1265 NC_011072.1 1225381 1225614 R Tn5253 hypothetical protein complement(1225381..1225614) Streptococcus pneumoniae G54 6479676 YP_002037974.1 CDS SPG_1266 NC_011072.1 1225665 1226750 R Tn5253 hypothetical protein complement(1225665..1226750) Streptococcus pneumoniae G54 6479688 YP_002037975.1 CDS SPG_1267 NC_011072.1 1226760 1227401 R Tn5253 hypothetical protein complement(1226760..1227401) Streptococcus pneumoniae G54 6478667 YP_002037976.1 CDS SPG_1268 NC_011072.1 1228560 1229423 D identified by match to protein family HMM PF01381; match to protein family HMM TIGR01716; positive transcriptional regulator MutRfamily 1228560..1229423 Streptococcus pneumoniae G54 6479208 YP_002037977.1 CDS SPG_1269 NC_011072.1 1229433 1231016 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding/permease complement(1229433..1231016) Streptococcus pneumoniae G54 6480282 YP_002037978.1 CDS SPG_1270 NC_011072.1 1231407 1231703 R Tn5253 hypothetical protein complement(1231407..1231703) Streptococcus pneumoniae G54 6479149 YP_002037979.1 CDS SPG_1271 NC_011072.1 1231717 1232001 R Tn5253 hypothetical protein complement(1231717..1232001) Streptococcus pneumoniae G54 6478881 YP_002037980.1 CDS SPG_1272 NC_011072.1 1232076 1238300 R identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF02384; match to protein family HMM PF04851; Tn5253 SNF2-related: helicase complement(1232076..1238300) Streptococcus pneumoniae G54 6479628 YP_002037981.1 CDS SPG_1273 NC_011072.1 1238348 1238758 R Tn5253 hypothetical protein complement(1238348..1238758) Streptococcus pneumoniae G54 6480579 YP_002037982.1 CDS SPG_1274 NC_011072.1 1238910 1239476 R hypothetical protein complement(1238910..1239476) Streptococcus pneumoniae G54 6479063 YP_002037983.1 CDS SPG_1275 NC_011072.1 1239715 1242528 R identified by match to protein family HMM PF01551; match to protein family HMM PF05257; Tn5253 hypothetical protein complement(1239715..1242528) Streptococcus pneumoniae G54 6480087 YP_002037984.1 CDS SPG_1276 NC_011072.1 1242540 1244897 R Tn5253 hypothetical protein complement(1242540..1244897) Streptococcus pneumoniae G54 6479266 YP_002037985.1 CDS SPG_1277 NC_011072.1 1244848 1245207 R Tn5253 hypothetical protein complement(1244848..1245207) Streptococcus pneumoniae G54 6480103 YP_002037986.1 CDS SPG_1278 NC_011072.1 1245261 1246115 R Tn5253 hypothetical protein complement(1245261..1246115) Streptococcus pneumoniae G54 6479517 YP_002037987.1 CDS SPG_1279 NC_011072.1 1246132 1246374 R Tn5253 hypothetical protein complement(1246132..1246374) Streptococcus pneumoniae G54 6479947 YP_002037988.1 CDS SPG_1280 NC_011072.1 1246395 1248272 R identified by match to protein family HMM PF02534; Tn5253 TraG protein complement(1246395..1248272) Streptococcus pneumoniae G54 6479883 YP_002037989.1 CDS SPG_1281 NC_011072.1 1248272 1248760 R Tn5253 hypothetical protein complement(1248272..1248760) Streptococcus pneumoniae G54 6480513 YP_002037990.1 CDS SPG_1282 NC_011072.1 1248750 1249049 R Tn5253 bacteriocine putative complement(1248750..1249049) Streptococcus pneumoniae G54 6480149 YP_002037991.1 CDS SPG_1283 NC_011072.1 1249643 1250275 R identified by match to protein family HMM PF00005; match to protein family HMM TIGR03608; bacteriocine associated ABC transporter ATP binding protein complement(1249643..1250275) Streptococcus pneumoniae G54 6479562 YP_002037992.1 CDS SPG_1284 NC_011072.1 1250277 1252286 R identified by match to protein family HMM TIGR01654; bacteriocine associated ABC transporter permease complement(1250277..1252286) Streptococcus pneumoniae G54 6478823 YP_002037993.1 CDS SPG_1285 NC_011072.1 1252941 1253393 R Tn5253 hypothetical protein complement(1252941..1253393) Streptococcus pneumoniae G54 6480125 YP_002037994.1 CDS SPG_1286 NC_011072.1 1253747 1254382 R hypothetical protein complement(1253747..1254382) Streptococcus pneumoniae G54 6479781 YP_002037995.1 CDS SPG_1287 NC_011072.1 1254672 1255259 R identified by match to protein family HMM PF02517; Tn5253 CAAX amino terminal protease family complement(1254672..1255259) Streptococcus pneumoniae G54 6480412 YP_002037996.1 CDS SPG_1288 NC_011072.1 1255262 1255495 R Tn5253 hypothetical protein complement(1255262..1255495) Streptococcus pneumoniae G54 6480479 YP_002037997.1 CDS SPG_1289 NC_011072.1 1255508 1255888 R Tn5253 hypothetical protein complement(1255508..1255888) Streptococcus pneumoniae G54 6478761 YP_002037998.1 CDS SPG_1290 NC_011072.1 1255881 1256330 R Tn5253 hypothetical protein complement(1255881..1256330) Streptococcus pneumoniae G54 6479990 YP_002037999.1 CDS SPG_1291 NC_011072.1 1256314 1257672 R identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675; Tn5253 C-5 cytosine-specific DNA methylase complement(1256314..1257672) Streptococcus pneumoniae G54 6479986 YP_002038000.1 CDS SPG_1292 NC_011072.1 1257771 1258550 R identified by match to protein family HMM PF06970; Tn5253 hypothetical protein complement(1257771..1258550) Streptococcus pneumoniae G54 6479410 YP_002038001.1 CDS SPG_1293 NC_011072.1 1258547 1258720 R Tn5253 hypothetical protein complement(1258547..1258720) Streptococcus pneumoniae G54 6479831 YP_002038002.1 CDS rplL NC_011072.1 1258922 1259290 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(1258922..1259290) Streptococcus pneumoniae G54 6479605 YP_002038003.1 CDS rplJ NC_011072.1 1259366 1259866 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(1259366..1259866) Streptococcus pneumoniae G54 6478901 YP_002038004.1 CDS SPG_1296 NC_011072.1 1260116 1261672 R identified by match to protein family HMM PF01979; match to protein family HMM PF07969; chlorohydrolase complement(1260116..1261672) Streptococcus pneumoniae G54 6479705 YP_002038005.1 CDS SPG_1298 NC_011072.1 1261767 1263515 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding/permease complement(1261767..1263515) Streptococcus pneumoniae G54 6478741 YP_002038006.1 CDS SPG_1299 NC_011072.1 1263517 1265241 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein complement(1263517..1265241) Streptococcus pneumoniae G54 6479639 YP_002038007.1 CDS SPG_1300 NC_011072.1 1265299 1266237 R identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; Peptide methionine sulfoxide reductase complement(1265299..1266237) Streptococcus pneumoniae G54 6479455 YP_002038008.1 CDS thrB NC_011072.1 1266487 1267356 R catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase complement(1266487..1267356) Streptococcus pneumoniae G54 6480767 YP_002038009.1 CDS metM NC_011072.1 1267358 1268644 R catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase complement(1267358..1268644) Streptococcus pneumoniae G54 6479363 YP_002038010.1 CDS SPG_1303 NC_011072.1 1268795 1269532 R enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein complement(1268795..1269532) Streptococcus pneumoniae G54 6480174 YP_002038011.1 CDS SPG_1304 NC_011072.1 1269732 1270766 R hypothetical protein complement(1269732..1270766) Streptococcus pneumoniae G54 6479829 YP_002038012.1 CDS SPG_1305 NC_011072.1 1270795 1272228 R identified by glimmer; putative; hypothetical protein complement(1270795..1272228) Streptococcus pneumoniae G54 6480028 YP_002038013.1 CDS SPG_1306 NC_011072.1 1272244 1273230 R identified by match to protein family HMM PF00535; group 2 family glycosyl transferase complement(1272244..1273230) Streptococcus pneumoniae G54 6479112 YP_002038014.1 CDS SPG_1307 NC_011072.1 1273232 1274332 R identified by match to protein family HMM PF00534; group 1 family glycosyl transferase complement(1273232..1274332) Streptococcus pneumoniae G54 6480281 YP_002038015.1 CDS SPG_1308 NC_011072.1 1274325 1275170 R identified by match to protein family HMM PF04991; phosphotransferase LicD3 complement(1274325..1275170) Streptococcus pneumoniae G54 6480134 YP_002038016.1 CDS SPG_1309 NC_011072.1 1275449 1276723 R identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; LytR family transcriptional regulator complement(1275449..1276723) Streptococcus pneumoniae G54 6480761 YP_002038017.1 CDS SPG_1310 NC_011072.1 1276720 1277568 R catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase complement(1276720..1277568) Streptococcus pneumoniae G54 6480052 YP_002038018.1 CDS SPG_1311 NC_011072.1 1277565 1278041 R identified by match to protein family HMM PF01202; shikimate kinase complement(1277565..1278041) Streptococcus pneumoniae G54 6478942 YP_002038019.1 CDS SPG_1312 NC_011072.1 1278034 1279317 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(1278034..1279317) Streptococcus pneumoniae G54 6479721 YP_002038020.1 CDS SPG_1313 NC_011072.1 1279409 1279747 R identified by match to protein family HMM PF06133; hypothetical protein complement(1279409..1279747) Streptococcus pneumoniae G54 6480184 YP_002038021.1 CDS tyrA NC_011072.1 1279758 1280861 R catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase complement(1279758..1280861) Streptococcus pneumoniae G54 6479437 YP_002038022.1 CDS aroC NC_011072.1 1280871 1282037 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(1280871..1282037) Streptococcus pneumoniae G54 6480237 YP_002038023.1 CDS aroB NC_011072.1 1282047 1283114 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(1282047..1283114) Streptococcus pneumoniae G54 6480607 YP_002038024.1 CDS aroE NC_011072.1 1283133 1283987 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(1283133..1283987) Streptococcus pneumoniae G54 6480260 YP_002038025.1 CDS aroD NC_011072.1 1283977 1284654 R catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase complement(1283977..1284654) Streptococcus pneumoniae G54 6479874 YP_002038026.1 CDS SPG_1319 NC_011072.1 1284651 1285814 R hypothetical protein complement(1284651..1285814) Streptococcus pneumoniae G54 6479364 YP_002038027.1 CDS SPG_1320 NC_011072.1 1286498 1288132 R identified by glimmer; putative; hypothetical protein complement(1286498..1288132) Streptococcus pneumoniae G54 6479556 YP_002038028.1 CDS SPG_1321 NC_011072.1 1288113 1288862 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1288113..1288862) Streptococcus pneumoniae G54 6479526 YP_002038029.1 CDS SPG_1322 NC_011072.1 1289041 1290495 D converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 1289041..1290495 Streptococcus pneumoniae G54 6480788 YP_002038030.1 CDS alaS NC_011072.1 1290585 1293203 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(1290585..1293203) Streptococcus pneumoniae G54 6479878 YP_002038031.1 CDS SPG_1324 NC_011072.1 1293225 1293710 R identified by match to protein family HMM PF04525; hypothetical protein complement(1293225..1293710) Streptococcus pneumoniae G54 6480681 YP_002038032.1 CDS potD NC_011072.1 1294493 1295563 R Ware, D.; (2005) J.Microb. 43:398-405; identified by match to protein family HMM PF01547; spermidine/putrescine ABC transporter spermidine/putrescine-binding protein complement(1294493..1295563) Streptococcus pneumoniae G54 6480374 YP_002038033.1 CDS potC NC_011072.1 1295560 1296333 R Ware, D.; (2005) J.Microb. 43:398-405; identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease complement(1295560..1296333) Streptococcus pneumoniae G54 6479059 YP_002038034.1 CDS potB NC_011072.1 1296330 1297136 R Ware, D.; (2005) J.Microb. 43:398-405; identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease complement(1296330..1297136) Streptococcus pneumoniae G54 6478816 YP_002038035.1 CDS potA NC_011072.1 1297117 1298274 R Ware, D.; (2005) J.Microb. 43:398-405; identified by match to protein family HMM PF00005; match to protein family HMM PF08402; spermidine/putrescine ABC transporter ATP-binding protein complement(1297117..1298274) Streptococcus pneumoniae G54 6480798 YP_002038036.1 CDS murB NC_011072.1 1298332 1299282 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(1298332..1299282) Streptococcus pneumoniae G54 6480432 YP_002038037.1 CDS SPG_1330 NC_011072.1 1299394 1299903 R contains potential frameshift; hypothetical protein complement(1299394..1299903) Streptococcus pneumoniae G54 6480595 YP_002038038.1 CDS SPG_1331 NC_011072.1 1299956 1300147 R contains potential frameshift; hypothetical protein complement(1299956..1300147) Streptococcus pneumoniae G54 6480230 YP_002038039.1 CDS SPG_1332 NC_011072.1 1300157 1300888 R identified by match to protein family HMM PF03306; match to protein family HMM TIGR01252; alpha-acetolactate decarboxylase complement(1300157..1300888) Streptococcus pneumoniae G54 6478734 YP_002038040.1 CDS SPG_1333 NC_011072.1 1301030 1301572 D contains potential frameshift; identified by match to protein family HMM PF00392; GntR family transcriptional regulator 1301030..1301572 Streptococcus pneumoniae G54 6479314 YP_002038041.1 CDS SPG_1334 NC_011072.1 1301569 1302303 D contains potential frameshift; GntR family transcriptional regulator 1301569..1302303 Streptococcus pneumoniae G54 6479132 YP_002038042.1 CDS SPG_1335 NC_011072.1 1302323 1303138 R identified by match to protein family HMM PF00497; ABC transporter amino acid-binding protein complement(1302323..1303138) Streptococcus pneumoniae G54 6479771 YP_002038043.1 CDS phoU NC_011072.1 1303295 1303948 R identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU complement(1303295..1303948) Streptococcus pneumoniae G54 6480638 YP_002038044.1 CDS SPG_1337 NC_011072.1 1303960 1304718 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1303960..1304718) Streptococcus pneumoniae G54 6479046 YP_002038045.1 CDS SPG_1338 NC_011072.1 1304731 1305534 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1304731..1305534) Streptococcus pneumoniae G54 6479168 YP_002038046.1 CDS SPG_1339 NC_011072.1 1305545 1306429 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease complement(1305545..1306429) Streptococcus pneumoniae G54 6479570 YP_002038047.1 CDS SPG_1340 NC_011072.1 1306419 1307336 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease complement(1306419..1307336) Streptococcus pneumoniae G54 6480727 YP_002038048.1 CDS SPG_1341 NC_011072.1 1307336 1308214 R identified by match to protein family HMM PF01547; match to protein family HMM TIGR02136; phosphate binding protein complement(1307336..1308214) Streptococcus pneumoniae G54 6479668 YP_002038049.1 CDS SPG_1342 NC_011072.1 1308444 1308557 D hypothetical protein 1308444..1308557 Streptococcus pneumoniae G54 6480529 YP_002038050.1 CDS SPG_1343 NC_011072.1 1308788 1310092 R identified by match to protein family HMM PF01189; NOL1/NOP2/sun family protein complement(1308788..1310092) Streptococcus pneumoniae G54 6480267 YP_002038051.1 CDS SPG_1344 NC_011072.1 1310093 1310866 R identified by match to protein family HMM PF00459; inositol monophosphatase family protein complement(1310093..1310866) Streptococcus pneumoniae G54 6480132 YP_002038052.1 CDS SPG_1345 NC_011072.1 1310856 1311134 R identified by glimmer; putative; hypothetical protein complement(1310856..1311134) Streptococcus pneumoniae G54 6478999 YP_002038053.1 CDS spxA NC_011072.1 1311134 1311535 R the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx complement(1311134..1311535) Streptococcus pneumoniae G54 6479337 YP_002038054.1 CDS SPG_1347 NC_011072.1 1311745 1312362 R identified by glimmer; putative; hypothetical protein complement(1311745..1312362) Streptococcus pneumoniae G54 6480578 YP_002038055.1 CDS SPG_1348 NC_011072.1 1312352 1313125 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01457; match to protein family HMM TIGR01460; haloacid dehalogenase-like hydrolase complement(1312352..1313125) Streptococcus pneumoniae G54 6480252 YP_002038056.1 CDS SPG_1349 NC_011072.1 1313136 1313873 R identified by match to protein family HMM PF01643; acyl-ACP thioesterase complement(1313136..1313873) Streptococcus pneumoniae G54 6480512 YP_002038057.1 CDS SPG_1350 NC_011072.1 1313878 1315008 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(1313878..1315008) Streptococcus pneumoniae G54 6480473 YP_002038058.1 CDS SPG_1351 NC_011072.1 1315092 1315481 R hypothetical protein complement(1315092..1315481) Streptococcus pneumoniae G54 6478800 YP_002038059.1 CDS SPG_1352 NC_011072.1 1315497 1315880 R identified by match to protein family HMM PF06103; hypothetical protein complement(1315497..1315880) Streptococcus pneumoniae G54 6480814 YP_002038060.1 CDS SPG_1353 NC_011072.1 1315881 1316669 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(1315881..1316669) Streptococcus pneumoniae G54 6480775 YP_002038061.1 CDS hprK NC_011072.1 1316662 1317597 R catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase complement(1316662..1317597) Streptococcus pneumoniae G54 6480165 YP_002038062.1 CDS rpsU NC_011072.1 1317727 1317903 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(1317727..1317903) Streptococcus pneumoniae G54 6480294 YP_002038063.1 CDS nagB NC_011072.1 1318043 1318750 R identified by similarity to RF:NP_358865.1; match to protein family HMM PF01182; glucosamine-6-phosphate deaminase complement(1318043..1318750) Streptococcus pneumoniae G54 6479779 YP_002038064.1 CDS queA NC_011072.1 1318901 1319929 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 1318901..1319929 Streptococcus pneumoniae G54 6479438 YP_002038065.1 CDS SPG_1358 NC_011072.1 1320590 1320979 R identified by match to protein family HMM PF01473; choline binding protein complement(1320590..1320979) Streptococcus pneumoniae G54 6478796 YP_002038066.1 CDS SPG_1359 NC_011072.1 1322440 1322991 R identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1322440..1322991) Streptococcus pneumoniae G54 6479965 YP_002038067.1 CDS nadE NC_011072.1 1323341 1324165 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1323341..1324165) Streptococcus pneumoniae G54 6479289 YP_002038068.1 CDS pncB NC_011072.1 1324162 1325622 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1324162..1325622) Streptococcus pneumoniae G54 6478900 YP_002038069.1 CDS SPG_1362 NC_011072.1 1325738 1326226 R hypothetical protein complement(1325738..1326226) Streptococcus pneumoniae G54 6480166 YP_002038070.1 CDS SPG_1363 NC_011072.1 1326216 1326425 R identified by match to protein family HMM PF01381; hypothetical protein complement(1326216..1326425) Streptococcus pneumoniae G54 6480058 YP_002038071.1 CDS SPG_1364 NC_011072.1 1326810 1327538 R identified by glimmer; putative; hypothetical protein complement(1326810..1327538) Streptococcus pneumoniae G54 6480547 YP_002038072.1 CDS SPG_1365 NC_011072.1 1327554 1327814 R contains potential frameshift; ABC transporter ATP-binding protein complement(1327554..1327814) Streptococcus pneumoniae G54 6480460 YP_002038073.1 CDS SPG_1366 NC_011072.1 1327900 1328274 R contains potential frameshift; ABC transporter ATP-binding protein complement(1327900..1328274) Streptococcus pneumoniae G54 6479039 YP_002038074.1 CDS SPG_1367 NC_011072.1 1328782 1329507 R identified by match to protein family HMM PF01136; protease complement(1328782..1329507) Streptococcus pneumoniae G54 6479743 YP_002038075.1 CDS SPG_1368 NC_011072.1 1329693 1329842 D hypothetical protein 1329693..1329842 Streptococcus pneumoniae G54 6480592 YP_002038076.1 CDS SPG_1369 NC_011072.1 1330097 1331383 R identified by match to protein family HMM PF01136; protease complement(1330097..1331383) Streptococcus pneumoniae G54 6479691 YP_002038077.1 CDS SPG_1370 NC_011072.1 1332007 1332189 D identified by similarity to GB:AAL00089.1; type II restriction endonuclease 1332007..1332189 Streptococcus pneumoniae G54 6479085 YP_002038078.1 CDS SPG_1371 NC_011072.1 1332373 1332561 D type II restriction endonuclease 1332373..1332561 Streptococcus pneumoniae G54 6478695 YP_002038079.1 CDS SPG_1372 NC_011072.1 1332558 1333748 D identified by match to protein family HMM PF01555; type II DNA modification methyltransferase 1332558..1333748 Streptococcus pneumoniae G54 6479372 YP_002038080.1 CDS guaA NC_011072.1 1333824 1335386 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(1333824..1335386) Streptococcus pneumoniae G54 6480659 YP_002038081.1 CDS SPG_1374 NC_011072.1 1335528 1336226 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 1335528..1336226 Streptococcus pneumoniae G54 6479354 YP_002038082.1 CDS SPG_1375 NC_011072.1 1336269 1337165 R identified by match to protein family HMM PF00892; hypothetical protein complement(1336269..1337165) Streptococcus pneumoniae G54 6479801 YP_002038083.1 CDS SPG_1376 NC_011072.1 1337174 1338109 R identified by glimmer; putative; hypothetical protein complement(1337174..1338109) Streptococcus pneumoniae G54 6480644 YP_002038084.1 CDS SPG_1377 NC_011072.1 1338106 1338831 R C3-degrading proteinase complement(1338106..1338831) Streptococcus pneumoniae G54 6478714 YP_002038085.1 CDS SPG_1378 NC_011072.1 1338915 1339550 R identified by match to protein family HMM PF00657; hypothetical protein complement(1338915..1339550) Streptococcus pneumoniae G54 6478738 YP_002038086.1 CDS SPG_1379 NC_011072.1 1339552 1340379 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1339552..1340379) Streptococcus pneumoniae G54 6479664 YP_002038087.1 CDS SPG_1380 NC_011072.1 1340483 1340737 R hypothetical protein complement(1340483..1340737) Streptococcus pneumoniae G54 6480216 YP_002038088.1 CDS SPG_1381 NC_011072.1 1340738 1341454 R identified by glimmer; putative; hypothetical protein complement(1340738..1341454) Streptococcus pneumoniae G54 6478743 YP_002038089.1 CDS def NC_011072.1 1341967 1342578 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1341967..1342578 Streptococcus pneumoniae G54 6480157 YP_002038090.1 CDS SPG_1383 NC_011072.1 1342623 1343351 D identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; TrmH family RNA methyltransferase 1342623..1343351 Streptococcus pneumoniae G54 6479147 YP_002038091.1 CDS trxB NC_011072.1 1343390 1344301 R identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF01266; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01292; thioredoxin reductase complement(1343390..1344301) Streptococcus pneumoniae G54 6479865 YP_002038092.1 CDS SPG_1385 NC_011072.1 1344367 1344591 R hypothetical protein complement(1344367..1344591) Streptococcus pneumoniae G54 6479444 YP_002038093.1 CDS SPG_1386 NC_011072.1 1344669 1345412 R identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein complement(1344669..1345412) Streptococcus pneumoniae G54 6479281 YP_002038094.1 CDS SPG_1387 NC_011072.1 1345412 1346212 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease complement(1345412..1346212) Streptococcus pneumoniae G54 6480378 YP_002038095.1 CDS SPG_1388 NC_011072.1 1346370 1346726 R identified by match to protein family HMM PF03960; match to protein family HMM TIGR01617; hypothetical protein complement(1346370..1346726) Streptococcus pneumoniae G54 6480431 YP_002038096.1 CDS SPG_1389 NC_011072.1 1346739 1347251 R identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589; methylated-DNA-[protein]-cysteine S-methyltransferase complement(1346739..1347251) Streptococcus pneumoniae G54 6479264 YP_002038097.1 CDS SPG_1390 NC_011072.1 1347251 1347745 R identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1347251..1347745) Streptococcus pneumoniae G54 6480683 YP_002038098.1 CDS SPG_1391 NC_011072.1 1347880 1348326 D identified by match to protein family HMM PF08876; hypothetical protein 1347880..1348326 Streptococcus pneumoniae G54 6480086 YP_002038099.1 CDS SPG_1392 NC_011072.1 1348323 1348970 D identified by match to protein family HMM PF03006; match to protein family HMM TIGR01065; hemolysin 1348323..1348970 Streptococcus pneumoniae G54 6479685 YP_002038100.1 CDS pdxT NC_011072.1 1348991 1349572 R with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT complement(1348991..1349572) Streptococcus pneumoniae G54 6479585 YP_002038101.1 CDS pdxS NC_011072.1 1349573 1350448 R with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS complement(1349573..1350448) Streptococcus pneumoniae G54 6479602 YP_002038102.1 CDS SPG_1395 NC_011072.1 1350600 1351355 R contains potential frameshift; identified by match to protein family HMM PF02852; NADH oxidase complement(1350600..1351355) Streptococcus pneumoniae G54 6479708 YP_002038103.1 CDS SPG_1396 NC_011072.1 1351405 1351980 R contains potential frameshift; identified by match to protein family HMM PF07992; NADH oxidase complement(1351405..1351980) Streptococcus pneumoniae G54 6480350 YP_002038104.1 CDS SPG_1397 NC_011072.1 1352122 1352277 D identified by glimmer; putative; hypothetical protein 1352122..1352277 Streptococcus pneumoniae G54 6479379 YP_002038105.1 CDS SPG_1398 NC_011072.1 1352274 1353197 D identified by match to protein family HMM PF02424; thiamine biosynthesis protein ApbE 1352274..1353197 Streptococcus pneumoniae G54 6480811 YP_002038106.1 CDS SPG_1399 NC_011072.1 1353257 1353862 D identified by match to protein family HMM PF03358; oxidoreductase 1353257..1353862 Streptococcus pneumoniae G54 6478982 YP_002038107.1 CDS SPG_1400 NC_011072.1 1353881 1355125 D identified by match to protein family HMM PF03358; oxidoreductase 1353881..1355125 Streptococcus pneumoniae G54 6479615 YP_002038108.1 CDS SPG_1401 NC_011072.1 1355242 1355499 R identified by glimmer; putative; hypothetical protein complement(1355242..1355499) Streptococcus pneumoniae G54 6480396 YP_002038109.1 CDS glyS NC_011072.1 1355541 1357577 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(1355541..1357577) Streptococcus pneumoniae G54 6480805 YP_002038110.1 CDS glyQ NC_011072.1 1357837 1358754 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(1357837..1358754) Streptococcus pneumoniae G54 6478764 YP_002038111.1 CDS SPG_1404 NC_011072.1 1358948 1359709 R identified by glimmer; putative; hypothetical protein complement(1358948..1359709) Streptococcus pneumoniae G54 6479759 YP_002038112.1 CDS SPG_1405 NC_011072.1 1359982 1360824 R identified by match to protein family HMM PF00248; aldo/keto reductase family oxidoreductase complement(1359982..1360824) Streptococcus pneumoniae G54 6480809 YP_002038113.1 CDS pgdA NC_011072.1 1361080 1362417 R Vollmer, W. (2000)J.Biol. Chem. 275, 20496-20501.; identified by similarity to GB:CAB96552.1; match to protein family HMM PF01522; peptidoglycan GlcNAc deacetylase PgdA complement(1361080..1362417) Streptococcus pneumoniae G54 6479325 YP_002038114.1 CDS SPG_1407 NC_011072.1 1362853 1363083 R hypothetical protein complement(1362853..1363083) Streptococcus pneumoniae G54 6478845 YP_002038115.1 CDS SPG_1408 NC_011072.1 1363316 1364293 D identified by match to protein family HMM PF01118; match to protein family HMM PF01408; oxidoreductase family protein 1363316..1364293 Streptococcus pneumoniae G54 6480819 YP_002038116.1 CDS SPG_1409 NC_011072.1 1364290 1365372 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; hypothetical protein 1364290..1365372 Streptococcus pneumoniae G54 6479319 YP_002038117.1 CDS SPG_1410 NC_011072.1 1365531 1365944 R IS630-SpnII transposase complement(1365531..1365944) Streptococcus pneumoniae G54 6478657 YP_002038118.1 CDS SPG_1411 NC_011072.1 1365976 1366380 R IS630-SpnII transposase complement(1365976..1366380) Streptococcus pneumoniae G54 6479114 YP_002038119.1 CDS SPG_1412 NC_011072.1 1366353 1366484 R hypothetical protein complement(1366353..1366484) Streptococcus pneumoniae G54 6480545 YP_002038120.1 CDS SPG_1413 NC_011072.1 1366868 1368064 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(1366868..1368064) Streptococcus pneumoniae G54 6478705 YP_002038121.1 CDS SPG_1414 NC_011072.1 1368407 1368529 R identified by glimmer; putative; hypothetical protein complement(1368407..1368529) Streptococcus pneumoniae G54 6479895 YP_002038122.1 CDS SPG_1415 NC_011072.1 1368975 1369844 R identified by match to protein family HMM PF00230; glycerol uptake facilitator protein complement(1368975..1369844) Streptococcus pneumoniae G54 6480673 YP_002038123.1 CDS SPG_1416 NC_011072.1 1370057 1370587 R identified by match to protein family HMM PF00746; match to protein family HMM PF06458; match to protein family HMM TIGR01167; cell wall surface anchor family protein complement(1370057..1370587) Streptococcus pneumoniae G54 6480027 YP_002038124.1 CDS SPG_1417 NC_011072.1 1370545 1371651 R hypothetical protein complement(1370545..1371651) Streptococcus pneumoniae G54 6479790 YP_002038125.1 CDS SPG_1418 NC_011072.1 1371762 1371908 R hypothetical protein complement(1371762..1371908) Streptococcus pneumoniae G54 6478863 YP_002038126.1 CDS SPG_1419 NC_011072.1 1372374 1372907 R IS630-Spn1 transposase complement(1372374..1372907) Streptococcus pneumoniae G54 6479355 YP_002038127.1 CDS SPG_1420 NC_011072.1 1372894 1373109 R transposase complement(1372894..1373109) Streptococcus pneumoniae G54 6479009 YP_002038128.1 CDS SPG_1421 NC_011072.1 1373454 1375172 D identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880; phosphoglucomutase/phosphomannomutase family protein 1373454..1375172 Streptococcus pneumoniae G54 6480668 YP_002038129.1 CDS SPG_1422 NC_011072.1 1375283 1375630 D identified by match to protein family HMM TIGR01295; bacteriocin transport accessory protein 1375283..1375630 Streptococcus pneumoniae G54 6478767 YP_002038130.1 CDS SPG_1423 NC_011072.1 1375908 1376744 R identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein complement(1375908..1376744) Streptococcus pneumoniae G54 6480142 YP_002038131.1 CDS SPG_1424 NC_011072.1 1376757 1377386 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1376757..1377386) Streptococcus pneumoniae G54 6478919 YP_002038132.1 CDS SPG_1425 NC_011072.1 1377396 1378037 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; ABC transporter permease complement(1377396..1378037) Streptococcus pneumoniae G54 6479915 YP_002038133.1 CDS SPG_1426 NC_011072.1 1378183 1379328 R identified by match to protein family HMM PF00515; match to protein family HMM PF07719; hypothetical protein complement(1378183..1379328) Streptococcus pneumoniae G54 6478805 YP_002038134.1 CDS SPG_1427 NC_011072.1 1379403 1380569 R identified by match to protein family HMM PF01594; hypothetical protein complement(1379403..1380569) Streptococcus pneumoniae G54 6480651 YP_002038135.1 CDS SPG_1428 NC_011072.1 1380713 1381726 D hypothetical protein 1380713..1381726 Streptococcus pneumoniae G54 6479305 YP_002038136.1 CDS atpC NC_011072.1 1381771 1382190 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon complement(1381771..1382190) Streptococcus pneumoniae G54 6479741 YP_002038137.1 CDS SPG_1430 NC_011072.1 1382201 1383607 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(1382201..1383607) Streptococcus pneumoniae G54 6479753 YP_002038138.1 CDS SPG_1431 NC_011072.1 1383693 1383974 R contains potential frameshift; Martin-Galiano, A.J. (2001) Mol.Micr. 41(6), 1327-1338; identified by match to protein family HMM PF00231; ATP synthase F1 subunit gamma complement(1383693..1383974) Streptococcus pneumoniae G54 6480022 YP_002038139.1 CDS SPG_1432 NC_011072.1 1383961 1384572 R contains potential frameshift; Martin-Galiano, A.J. (2001) Mol.Micr. 41(6), 1327-1338; identified by match to protein family HMM PF00231; ATP synthase F1 subunit gamma complement(1383961..1384572) Streptococcus pneumoniae G54 6479847 YP_002038140.1 CDS SPG_1433 NC_011072.1 1384588 1386093 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(1384588..1386093) Streptococcus pneumoniae G54 6479401 YP_002038141.1 CDS SPG_1434 NC_011072.1 1386108 1386644 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(1386108..1386644) Streptococcus pneumoniae G54 6479217 YP_002038142.1 CDS atpB NC_011072.1 1386644 1387138 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B complement(1386644..1387138) Streptococcus pneumoniae G54 6479109 YP_002038143.1 CDS atpA NC_011072.1 1387152 1387868 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(1387152..1387868) Streptococcus pneumoniae G54 6479738 YP_002038144.1 CDS atpC NC_011072.1 1387903 1388103 R produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(1387903..1388103) Streptococcus pneumoniae G54 6479910 YP_002038145.1 CDS SPG_1438 NC_011072.1 1388178 1388333 R IS1239 transposase complement(1388178..1388333) Streptococcus pneumoniae G54 6479103 YP_002038146.1 CDS SPG_1439 NC_011072.1 1388355 1389188 R IS1239 transposase complement(1388355..1389188) Streptococcus pneumoniae G54 6479693 YP_002038147.1 CDS SPG_1440 NC_011072.1 1389562 1389960 R identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1389562..1389960) Streptococcus pneumoniae G54 6480110 YP_002038148.1 CDS greA NC_011072.1 1390333 1390815 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1390333..1390815) Streptococcus pneumoniae G54 6480434 YP_002038149.1 CDS SPG_1442 NC_011072.1 1390886 1392541 R identified by match to protein family HMM PF02618; match to protein family HMM TIGR00247; hypothetical protein complement(1390886..1392541) Streptococcus pneumoniae G54 6479923 YP_002038150.1 CDS SPG_1443 NC_011072.1 1392622 1393116 R identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1392622..1393116) Streptococcus pneumoniae G54 6480107 YP_002038151.1 CDS SPG_1444 NC_011072.1 1393113 1393577 R identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1393113..1393577) Streptococcus pneumoniae G54 6480208 YP_002038152.1 CDS murC NC_011072.1 1393587 1394921 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(1393587..1394921) Streptococcus pneumoniae G54 6479129 YP_002038153.1 CDS SPG_1446 NC_011072.1 1394932 1395549 R identified by glimmer; putative; hypothetical protein complement(1394932..1395549) Streptococcus pneumoniae G54 6478679 YP_002038154.1 CDS SPG_1447 NC_011072.1 1395597 1398695 R identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434; match to protein family HMM PF08455; SNF2 family protein complement(1395597..1398695) Streptococcus pneumoniae G54 6479945 YP_002038155.1 CDS SPG_1449 NC_011072.1 1398788 1399954 R identified by match to protein family HMM PF00155; aminotransferase complement(1398788..1399954) Streptococcus pneumoniae G54 6480297 YP_002038156.1 CDS metB NC_011072.1 1399962 1401056 R catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase complement(1399962..1401056) Streptococcus pneumoniae G54 6479351 YP_002038157.1 CDS SPG_1451 NC_011072.1 1401213 1401758 R contains potential frameshift; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1401213..1401758) Streptococcus pneumoniae G54 6479090 YP_002038158.1 CDS SPG_1452 NC_011072.1 1401794 1402333 R contains potential frameshift; identified by glimmer; putative; hypothetical protein complement(1401794..1402333) Streptococcus pneumoniae G54 6480268 YP_002038159.1 CDS SPG_1453 NC_011072.1 1402342 1402635 R contains potential frameshift; identified by glimmer; putative; hypothetical protein complement(1402342..1402635) Streptococcus pneumoniae G54 6479631 YP_002038160.1 CDS SPG_1454 NC_011072.1 1403048 1405006 R identified by match to protein family HMM PF00496; oligopeptide ABC transporter oligopeptide-binding protein complement(1403048..1405006) Streptococcus pneumoniae G54 6479358 YP_002038161.1 CDS SPG_1455 NC_011072.1 1405209 1406831 R identified by match to protein family HMM PF01943; polysaccharide biosynthesis protein complement(1405209..1406831) Streptococcus pneumoniae G54 6479040 YP_002038162.1 CDS murE NC_011072.1 1406937 1408382 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1406937..1408382 Streptococcus pneumoniae G54 6480031 YP_002038163.1 CDS SPG_1457 NC_011072.1 1408428 1408622 R identified by match to protein family HMM PF05532; hypothetical protein complement(1408428..1408622) Streptococcus pneumoniae G54 6479435 YP_002038164.1 CDS SPG_1458 NC_011072.1 1408728 1409318 R identified by match to protein family HMM PF08820; hypothetical protein complement(1408728..1409318) Streptococcus pneumoniae G54 6480387 YP_002038165.1 CDS SPG_1459 NC_011072.1 1409355 1409867 R hypothetical protein complement(1409355..1409867) Streptococcus pneumoniae G54 6478672 YP_002038166.1 CDS ppa NC_011072.1 1409954 1410889 R catalyzes the hydrolysis of pyrophosphate to phosphate; putative manganese-dependent inorganic pyrophosphatase complement(1409954..1410889) Streptococcus pneumoniae G54 6479877 YP_002038167.1 CDS SPG_1461 NC_011072.1 1410917 1411258 R identified by match to protein family HMM PF01541; hypothetical protein complement(1410917..1411258) Streptococcus pneumoniae G54 6480397 YP_002038168.1 CDS SPG_1462 NC_011072.1 1411248 1411997 R identified by match to protein family HMM PF05175; hypothetical protein complement(1411248..1411997) Streptococcus pneumoniae G54 6479204 YP_002038169.1 CDS SPG_1463 NC_011072.1 1412051 1412410 R identified by glimmer; putative; hypothetical protein complement(1412051..1412410) Streptococcus pneumoniae G54 6478754 YP_002038170.1 CDS SPG_1464 NC_011072.1 1412412 1413812 R identified by match to protein family HMM PF00160; match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein/peptidyl-prolyl cis-trans isomerase complement(1412412..1413812) Streptococcus pneumoniae G54 6478908 YP_002038171.1 CDS rpsR NC_011072.1 1414107 1414346 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(1414107..1414346) Streptococcus pneumoniae G54 6479713 YP_002038172.1 CDS SPG_1466 NC_011072.1 1414378 1414848 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1414378..1414848) Streptococcus pneumoniae G54 6479808 YP_002038173.1 CDS rpsF NC_011072.1 1414860 1415150 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(1414860..1415150) Streptococcus pneumoniae G54 6479516 YP_002038174.1 CDS asnC NC_011072.1 1415303 1416646 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(1415303..1416646) Streptococcus pneumoniae G54 6479094 YP_002038175.1 CDS SPG_1469 NC_011072.1 1416665 1417030 R identified by match to protein family HMM PF00903; glyoxalase family protein complement(1416665..1417030) Streptococcus pneumoniae G54 6479740 YP_002038176.1 CDS aspC NC_011072.1 1417023 1418210 R catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase complement(1417023..1418210) Streptococcus pneumoniae G54 6480670 YP_002038177.1 CDS SPG_1471 NC_011072.1 1418207 1418695 R hypothetical protein complement(1418207..1418695) Streptococcus pneumoniae G54 6479843 YP_002038178.1 CDS SPG_1472 NC_011072.1 1418762 1418878 R identified by glimmer; putative; hypothetical protein complement(1418762..1418878) Streptococcus pneumoniae G54 6478862 YP_002038179.1 CDS SPG_1473 NC_011072.1 1419016 1419564 D identified by match to protein family HMM PF02525; match to protein family HMM PF03358; NADPH-dependent FMN reductase 1419016..1419564 Streptococcus pneumoniae G54 6479744 YP_002038180.1 CDS SPG_1474 NC_011072.1 1419842 1420570 R identified by match to protein family HMM PF03883; hypothetical protein complement(1419842..1420570) Streptococcus pneumoniae G54 6478985 YP_002038181.1 CDS SPG_1475 NC_011072.1 1420649 1420813 R hypothetical protein complement(1420649..1420813) Streptococcus pneumoniae G54 6480032 YP_002038182.1 CDS SPG_1476 NC_011072.1 1420980 1422575 R hypothetical protein complement(1420980..1422575) Streptococcus pneumoniae G54 6479128 YP_002038183.1 CDS defA NC_011072.1 1422587 1422997 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(1422587..1422997) Streptococcus pneumoniae G54 6479835 YP_002038184.1 CDS SPG_1478 NC_011072.1 1423113 1423904 R YghU; B2989; one of eight putative glutathione transferase proteins from E. coli; putative glutathione S-transferase YghU complement(1423113..1423904) Streptococcus pneumoniae G54 6479458 YP_002038185.1 CDS SPG_1479 NC_011072.1 1423917 1426613 R identified by match to protein family HMM PF00122; match to protein family HMM PF00689; match to protein family HMM PF00690; match to protein family HMM PF00702; match to protein family HMM TIGR01494; E1-E2 family cation-transporting ATPase complement(1423917..1426613) Streptococcus pneumoniae G54 6480590 YP_002038186.1 CDS SPG_1480 NC_011072.1 1426917 1428101 D identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation efflux family protein 1426917..1428101 Streptococcus pneumoniae G54 6479333 YP_002038187.1 CDS SPG_1481 NC_011072.1 1428244 1430115 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1428244..1430115) Streptococcus pneumoniae G54 6480214 YP_002038188.1 CDS SPG_1482 NC_011072.1 1430112 1431311 R catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase complement(1430112..1431311) Streptococcus pneumoniae G54 6479898 YP_002038189.1 CDS dapB NC_011072.1 1431308 1432075 R catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase complement(1431308..1432075) Streptococcus pneumoniae G54 6480280 YP_002038190.1 CDS SPG_1484 NC_011072.1 1432352 1433200 R identified by glimmer; putative; hypothetical protein complement(1432352..1433200) Streptococcus pneumoniae G54 6480626 YP_002038191.1 CDS SPG_1485 NC_011072.1 1433202 1433576 R identified by match to protein family HMM PF06619; hypothetical protein complement(1433202..1433576) Streptococcus pneumoniae G54 6479549 YP_002038192.1 CDS glmM NC_011072.1 1433650 1435002 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(1433650..1435002) Streptococcus pneumoniae G54 6479117 YP_002038193.1 CDS SPG_1487 NC_011072.1 1435026 1435805 R identified by match to protein family HMM PF07949; hypothetical protein complement(1435026..1435805) Streptococcus pneumoniae G54 6480606 YP_002038194.1 CDS SPG_1488 NC_011072.1 1435792 1436649 R identified by match to protein family HMM PF02457; match to protein family HMM TIGR00159; hypothetical protein complement(1435792..1436649) Streptococcus pneumoniae G54 6480600 YP_002038195.1 CDS SPG_1489 NC_011072.1 1436785 1437753 D identified by match to protein family HMM PF00070; match to protein family HMM PF07992; pyridine nucleotide-disulphide oxidoreductase family protein 1436785..1437753 Streptococcus pneumoniae G54 6479230 YP_002038196.1 CDS SPG_1490 NC_011072.1 1437787 1438698 R identified by match to protein family HMM PF02650; match to protein family HMM TIGR00647; hypothetical protein complement(1437787..1438698) Streptococcus pneumoniae G54 6479505 YP_002038197.1 CDS SPG_1491 NC_011072.1 1438695 1439672 R identified by match to protein family HMM PF01933; match to protein family HMM TIGR01826; hypothetical protein complement(1438695..1439672) Streptococcus pneumoniae G54 6480654 YP_002038198.1 CDS SPG_1492 NC_011072.1 1439669 1440559 R identified by glimmer; putative; hypothetical protein complement(1439669..1440559) Streptococcus pneumoniae G54 6478758 YP_002038199.1 CDS SPG_1493 NC_011072.1 1440611 1440991 R identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004; endoribonuclease L-PSP complement(1440611..1440991) Streptococcus pneumoniae G54 6479381 YP_002038200.1 CDS engB NC_011072.1 1441002 1441589 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(1441002..1441589) Streptococcus pneumoniae G54 6480523 YP_002038201.1 CDS clpX NC_011072.1 1441598 1442830 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1441598..1442830) Streptococcus pneumoniae G54 6480682 YP_002038202.1 CDS SPG_1496 NC_011072.1 1442862 1443032 R hypothetical protein complement(1442862..1443032) Streptococcus pneumoniae G54 6480417 YP_002038203.1 CDS folA NC_011072.1 1443032 1443538 R identified by match to protein family HMM PF00186; dihydrofolate reductase complement(1443032..1443538) Streptococcus pneumoniae G54 6479932 YP_002038204.1 CDS SPG_1498 NC_011072.1 1443668 1444186 R identified by match to protein family HMM PF00210; ferritin-like domain complement(1443668..1444186) Streptococcus pneumoniae G54 6479462 YP_002038205.1 CDS lytC NC_011072.1 1444682 1446154 R identified by match to protein family HMM PF01183; match to protein family HMM PF01473; endo-beta-N-acetylglucosaminidase complement(1444682..1446154) Streptococcus pneumoniae G54 6480618 YP_002038206.1 CDS tpiA NC_011072.1 1446225 1446983 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(1446225..1446983) Streptococcus pneumoniae G54 6480356 YP_002038207.1 CDS SPG_1501 NC_011072.1 1447081 1447758 R identified by match to protein family HMM PF04271; match to protein family HMM TIGR01446; hypothetical protein complement(1447081..1447758) Streptococcus pneumoniae G54 6479436 YP_002038208.1 CDS metA NC_011072.1 1447767 1448711 R catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase complement(1447767..1448711) Streptococcus pneumoniae G54 6480006 YP_002038209.1 CDS SPG_1503 NC_011072.1 1448893 1449405 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(1448893..1449405) Streptococcus pneumoniae G54 6479618 YP_002038210.1 CDS SPG_1504 NC_011072.1 1449492 1450250 R identified by match to protein family HMM PF08241; match to protein family HMM PF08242; hypothetical protein complement(1449492..1450250) Streptococcus pneumoniae G54 6479321 YP_002038211.1 CDS SPG_1505 NC_011072.1 1450751 1451881 R identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; ABC transporter ATP-binding protein complement(1450751..1451881) Streptococcus pneumoniae G54 6480560 YP_002038212.1 CDS SPG_1506 NC_011072.1 1451982 1452104 D hypothetical protein 1451982..1452104 Streptococcus pneumoniae G54 6480456 YP_002038213.1 CDS SPG_1508 NC_011072.1 1452331 1452906 R identified by match to protein family HMM PF00857; isochorismatase family protein complement(1452331..1452906) Streptococcus pneumoniae G54 6480329 YP_002038214.1 CDS codY NC_011072.1 1452906 1453694 R CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY complement(1452906..1453694) Streptococcus pneumoniae G54 6478994 YP_002038215.1 CDS SPG_1510 NC_011072.1 1453958 1455532 R identified by match to protein family HMM PF00270; match to protein family HMM PF00271; ATP-dependent RNA helicase complement(1453958..1455532) Streptococcus pneumoniae G54 6478953 YP_002038216.1 CDS SPG_1511 NC_011072.1 1455731 1456957 R identified by match to protein family HMM PF07690; oxalate:formate antiporter complement(1455731..1456957) Streptococcus pneumoniae G54 6478867 YP_002038217.1 CDS SPG_1512 NC_011072.1 1457150 1458466 D Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 1457150..1458466 Streptococcus pneumoniae G54 6480751 YP_002038218.1 CDS SPG_1513 NC_011072.1 1458565 1459908 D identified by match to protein family HMM PF08245; match to protein family HMM PF08353; hypothetical protein 1458565..1459908 Streptococcus pneumoniae G54 6478969 YP_002038219.1 CDS SPG_1514 NC_011072.1 1459908 1460690 D identified by match to protein family HMM PF07685; hypothetical protein 1459908..1460690 Streptococcus pneumoniae G54 6479540 YP_002038220.1 CDS pepQ NC_011072.1 1460816 1461898 D identified by match to protein family HMM PF00557; match to protein family HMM PF01321; proline dipeptidase PepQ 1460816..1461898 Streptococcus pneumoniae G54 6479067 YP_002038221.1 CDS SPG_1516 NC_011072.1 1462219 1463052 R identified by match to protein family HMM PF00665; IS3-Spn1 transposase complement(1462219..1463052) Streptococcus pneumoniae G54 6479073 YP_002038222.1 CDS SPG_1517 NC_011072.1 1463052 1463219 R contains potential frameshift; transposase IS3-Spn1 complement(1463052..1463219) Streptococcus pneumoniae G54 6479995 YP_002038223.1 CDS SPG_1518 NC_011072.1 1463356 1463568 R contains potential frameshift; IS3-Spn1 transposase complement(1463356..1463568) Streptococcus pneumoniae G54 6479750 YP_002038224.1 CDS SPG_1519 NC_011072.1 1463644 1463763 D identified by glimmer; putative; hypothetical protein 1463644..1463763 Streptococcus pneumoniae G54 6479722 YP_002038225.1 CDS SPG_1520 NC_011072.1 1463792 1464253 R hypothetical protein complement(1463792..1464253) Streptococcus pneumoniae G54 6479640 YP_002038226.1 CDS SPG_1521 NC_011072.1 1464231 1465004 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(1464231..1465004) Streptococcus pneumoniae G54 6479660 YP_002038227.1 CDS truA NC_011072.1 1464994 1465743 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(1464994..1465743) Streptococcus pneumoniae G54 6480225 YP_002038228.1 CDS SPG_1524 NC_011072.1 1465923 1466084 D hypothetical protein 1465923..1466084 Streptococcus pneumoniae G54 6479984 YP_002038229.1 CDS SPG_1523 NC_011072.1 1466056 1467207 R identified by match to protein family HMM PF07690; major facilitator family transporter complement(1466056..1467207) Streptococcus pneumoniae G54 6479700 YP_002038230.1 CDS SPG_1525 NC_011072.1 1467447 1468076 R hypothetical protein complement(1467447..1468076) Streptococcus pneumoniae G54 6480179 YP_002038231.1 CDS SPG_1526 NC_011072.1 1468079 1468417 R identified by match to protein family HMM PF03831; match to protein family HMM PF08274; match to protein family HMM TIGR00686; alkylphosphonate utilization operon protein PhnA complement(1468079..1468417) Streptococcus pneumoniae G54 6478903 YP_002038232.1 CDS cmk NC_011072.1 1468547 1469218 R Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase complement(1468547..1469218) Streptococcus pneumoniae G54 6478928 YP_002038233.1 CDS SPG_1528 NC_011072.1 1469227 1469703 R hypothetical protein complement(1469227..1469703) Streptococcus pneumoniae G54 6480760 YP_002038234.1 CDS SPG_1529 NC_011072.1 1469755 1469961 D ferredoxin 1469755..1469961 Streptococcus pneumoniae G54 6478988 YP_002038235.1 CDS SPG_1530 NC_011072.1 1470012 1470977 R identified by match to protein family HMM PF00535; group 2 family glycosyl transferase complement(1470012..1470977) Streptococcus pneumoniae G54 6479158 YP_002038236.1 CDS SPG_1531 NC_011072.1 1470979 1471998 R identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase complement(1470979..1471998) Streptococcus pneumoniae G54 6479373 YP_002038237.1 CDS SPG_1532 NC_011072.1 1472344 1473447 R identified by match to protein family HMM PF01266; FAD dependent oxidoreductase complement(1472344..1473447) Streptococcus pneumoniae G54 6480808 YP_002038238.1 CDS SPG_1533 NC_011072.1 1473464 1474261 R identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486; hypothetical protein complement(1473464..1474261) Streptococcus pneumoniae G54 6479376 YP_002038239.1 CDS SPG_1534 NC_011072.1 1474248 1474925 R identified by glimmer; putative; hypothetical protein complement(1474248..1474925) Streptococcus pneumoniae G54 6479839 YP_002038240.1 CDS SPG_1535 NC_011072.1 1475027 1477363 R identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; E1-E2 family cation-transporting ATPase complement(1475027..1477363) Streptococcus pneumoniae G54 6478910 YP_002038241.1 CDS SPG_1536 NC_011072.1 1477496 1478245 D identified by match to protein family HMM PF01553; acyltransferase domain-containing protein 1477496..1478245 Streptococcus pneumoniae G54 6480333 YP_002038242.1 CDS SPG_1537 NC_011072.1 1478538 1479152 R identified by match to protein family HMM PF03596; match to protein family HMM TIGR00779; cadmium resistance transporter complement(1478538..1479152) Streptococcus pneumoniae G54 6479587 YP_002038243.1 CDS rpsO NC_011072.1 1479965 1480234 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(1479965..1480234) Streptococcus pneumoniae G54 6479834 YP_002038244.1 CDS SPG_1539 NC_011072.1 1480513 1481004 R hypothetical protein complement(1480513..1481004) Streptococcus pneumoniae G54 6479424 YP_002038245.1 CDS SPG_1540 NC_011072.1 1481067 1481189 D identified by glimmer; putative; hypothetical protein 1481067..1481189 Streptococcus pneumoniae G54 6478954 YP_002038246.1 CDS SPG_1541 NC_011072.1 1481863 1482084 D hypothetical protein 1481863..1482084 Streptococcus pneumoniae G54 6480526 YP_002038247.1 CDS thrS NC_011072.1 1482244 1484187 D catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1482244..1484187 Streptococcus pneumoniae G54 6479179 YP_002038248.1 CDS SPG_1543 NC_011072.1 1484236 1485210 R identified by match to protein family HMM PF02518; histidine kinase complement(1484236..1485210) Streptococcus pneumoniae G54 6478746 YP_002038249.1 CDS SPG_1544 NC_011072.1 1485203 1485880 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator complement(1485203..1485880) Streptococcus pneumoniae G54 6479223 YP_002038250.1 CDS SPG_1545 NC_011072.1 1486036 1487109 D hypothetical protein 1486036..1487109 Streptococcus pneumoniae G54 6480588 YP_002038251.1 CDS SPG_1546 NC_011072.1 1487200 1487502 R hypothetical protein complement(1487200..1487502) Streptococcus pneumoniae G54 6478827 YP_002038252.1 CDS SPG_1547 NC_011072.1 1487570 1488007 R identified by match to protein family HMM PF02082; RRF2 family protein complement(1487570..1488007) Streptococcus pneumoniae G54 6479269 YP_002038253.1 CDS SPG_1548 NC_011072.1 1488083 1488925 R identified by match to protein family HMM PF00149; hypothetical protein complement(1488083..1488925) Streptococcus pneumoniae G54 6479827 YP_002038254.1 CDS dtxR NC_011072.1 1489037 1489687 D identified by match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF02742; match to protein family HMM PF04023; iron-dependent transcriptional regulator 1489037..1489687 Streptococcus pneumoniae G54 6478878 YP_002038255.1 CDS SPG_1550 NC_011072.1 1489668 1489838 D hypothetical protein 1489668..1489838 Streptococcus pneumoniae G54 6479804 YP_002038256.1 CDS SPG_1551 NC_011072.1 1489864 1490541 D identified by glimmer; putative; hypothetical protein 1489864..1490541 Streptococcus pneumoniae G54 6480244 YP_002038257.1 CDS SPG_1552 NC_011072.1 1490643 1491056 D hypothetical protein 1490643..1491056 Streptococcus pneumoniae G54 6480308 YP_002038258.1 CDS SPG_1553 NC_011072.1 1491330 1491491 D hypothetical protein 1491330..1491491 Streptococcus pneumoniae G54 6480001 YP_002038259.1 CDS SPG_1554 NC_011072.1 1491530 1491973 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(1491530..1491973) Streptococcus pneumoniae G54 6478947 YP_002038260.1 CDS SPG_1555 NC_011072.1 1492003 1494225 R identified by match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691; GTP pyrophosphokinase complement(1492003..1494225) Streptococcus pneumoniae G54 6478756 YP_002038261.1 CDS SPG_1556 NC_011072.1 1495219 1495848 D identified by match to protein family HMM PF00753; hypothetical protein 1495219..1495848 Streptococcus pneumoniae G54 6479153 YP_002038262.1 CDS SPG_1557 NC_011072.1 1495971 1497863 R identified by match to protein family HMM PF01431; match to protein family HMM PF05649; endopeptidase O complement(1495971..1497863) Streptococcus pneumoniae G54 6480422 YP_002038263.1 CDS psaB NC_011072.1 1498090 1498812 D Dintilhac A, Mol Microbiol. 1997 Aug;25(4):727-39.; identified by match to protein family HMM PF00005; manganese ABC transporter ATP-binding protein 1498090..1498812 Streptococcus pneumoniae G54 6478858 YP_002038264.1 CDS psaC NC_011072.1 1498809 1499657 D Dintilhac A, Mol Microbiol. 1997 Aug;25(4):727-39.; identified by match to protein family HMM PF00950; manganese ABC transporter permease 1498809..1499657 Streptococcus pneumoniae G54 6480715 YP_002038265.1 CDS psaA NC_011072.1 1499689 1500618 D Dintilhac A, Mol Microbiol. 1997 Aug;25(4):727-39.; identified by match to protein family HMM PF01297; manganese ABC transporter substrate-binding lipoprotein 1499689..1500618 Streptococcus pneumoniae G54 6480660 YP_002038266.1 CDS tpx NC_011072.1 1500741 1501232 D antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1500741..1501232 Streptococcus pneumoniae G54 6479483 YP_002038267.1 CDS SPG_1562 NC_011072.1 1501328 1504036 R identified by match to protein family HMM PF02687; ABC transporter permease complement(1501328..1504036) Streptococcus pneumoniae G54 6480415 YP_002038268.1 CDS SPG_1563 NC_011072.1 1504038 1504739 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1504038..1504739) Streptococcus pneumoniae G54 6480414 YP_002038269.1 CDS SPG_1564 NC_011072.1 1504989 1507400 R hypothetical protein complement(1504989..1507400) Streptococcus pneumoniae G54 6480635 YP_002038270.1 CDS gpmA NC_011072.1 1507453 1508145 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(1507453..1508145) Streptococcus pneumoniae G54 6479975 YP_002038271.1 CDS SPG_1566 NC_011072.1 1508196 1508384 R hypothetical protein complement(1508196..1508384) Streptococcus pneumoniae G54 6480272 YP_002038272.1 CDS SPG_1567 NC_011072.1 1508680 1509042 R identified by glimmer; putative; hypothetical protein complement(1508680..1509042) Streptococcus pneumoniae G54 6479666 YP_002038273.1 CDS ileS NC_011072.1 1509451 1512243 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase complement(1509451..1512243) Streptococcus pneumoniae G54 6479098 YP_002038274.1 CDS SPG_1569 NC_011072.1 1512496 1512612 R identified by glimmer; putative; hypothetical protein complement(1512496..1512612) Streptococcus pneumoniae G54 6479215 YP_002038275.1 CDS SPG_1570 NC_011072.1 1512591 1513379 R identified by match to protein family HMM PF05103; cell division protein DivIVA complement(1512591..1513379) Streptococcus pneumoniae G54 6480461 YP_002038276.1 CDS SPG_1571 NC_011072.1 1513388 1514173 R identified by match to protein family HMM PF01479; YlmH protein complement(1513388..1514173) Streptococcus pneumoniae G54 6479135 YP_002038277.1 CDS SPG_1572 NC_011072.1 1514170 1514433 R identified by match to protein family HMM PF02325; YlmG protein complement(1514170..1514433) Streptococcus pneumoniae G54 6479212 YP_002038278.1 CDS SPG_1573 NC_011072.1 1514433 1514972 R identified by match to protein family HMM PF04472; YlmF protein complement(1514433..1514972) Streptococcus pneumoniae G54 6479619 YP_002038279.1 CDS SPG_1574 NC_011072.1 1514982 1515653 R identified by match to protein family HMM TIGR00044; YlmE protein complement(1514982..1515653) Streptococcus pneumoniae G54 6479050 YP_002038280.1 CDS ftsZ NC_011072.1 1515658 1516917 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(1515658..1516917) Streptococcus pneumoniae G54 6479589 YP_002038281.1 CDS ftsA NC_011072.1 1516934 1518307 R identified by match to protein family HMM PF02491; match to protein family HMM TIGR01174; cell division protein FtsA complement(1516934..1518307) Streptococcus pneumoniae G54 6479621 YP_002038282.1 CDS SPG_1577 NC_011072.1 1518526 1519230 R identified by glimmer; putative; hypothetical protein complement(1518526..1519230) Streptococcus pneumoniae G54 6479917 YP_002038283.1 CDS SPG_1578 NC_011072.1 1519321 1519932 R identified by match to protein family HMM PF00293; MutT/nudix family protein complement(1519321..1519932) Streptococcus pneumoniae G54 6480490 YP_002038284.1 CDS murF NC_011072.1 1519919 1521292 R identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01143; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase complement(1519919..1521292) Streptococcus pneumoniae G54 6479232 YP_002038285.1 CDS ddl NC_011072.1 1521376 1522419 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(1521376..1522419) Streptococcus pneumoniae G54 6479661 YP_002038286.1 CDS recR NC_011072.1 1522595 1523191 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(1522595..1523191) Streptococcus pneumoniae G54 6479311 YP_002038287.1 CDS SPG_1582 NC_011072.1 1523202 1525259 R identified by match to protein family HMM PF00905; match to protein family HMM PF03717; penicillin-binding protein 2B complement(1523202..1525259) Streptococcus pneumoniae G54 6480334 YP_002038288.1 CDS SPG_1583 NC_011072.1 1525459 1526310 D identified by match to protein family HMM PF01380; match to protein family HMM PF01418; phosphosugar-binding transcriptional regulator 1525459..1526310 Streptococcus pneumoniae G54 6478760 YP_002038289.1 CDS SPG_1584 NC_011072.1 1526326 1527210 R identified by match to protein family HMM PF00480; glucokinase complement(1526326..1527210) Streptococcus pneumoniae G54 6479734 YP_002038290.1 CDS SPG_1585 NC_011072.1 1527228 1528145 R Steenbergen, S.M.: J Bacteriol. 2006 Sep;188(17):6195-206.; identified by match to protein family HMM PF00701; N-acetylneuraminate lyase complement(1527228..1528145) Streptococcus pneumoniae G54 6480729 YP_002038291.1 CDS SPG_1586 NC_011072.1 1528314 1528958 R identified by match to protein family HMM PF04854; hypothetical protein complement(1528314..1528958) Streptococcus pneumoniae G54 6480718 YP_002038292.1 CDS SPG_1587 NC_011072.1 1529244 1529378 R hypothetical protein complement(1529244..1529378) Streptococcus pneumoniae G54 6479023 YP_002038293.1 CDS SPG_1588 NC_011072.1 1529694 1530146 R identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein complement(1529694..1530146) Streptococcus pneumoniae G54 6479409 YP_002038294.1 CDS SPG_1589 NC_011072.1 1530419 1531258 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1530419..1531258) Streptococcus pneumoniae G54 6479539 YP_002038295.1 CDS SPG_1590 NC_011072.1 1531274 1532161 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1531274..1532161) Streptococcus pneumoniae G54 6480057 YP_002038296.1 CDS SPG_1591 NC_011072.1 1532393 1533721 R identified by match to protein family HMM PF01547; ABC transporter substrate binding protein complement(1532393..1533721) Streptococcus pneumoniae G54 6480073 YP_002038297.1 CDS SPG_1592 NC_011072.1 1533846 1535363 R identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; PTS system transporter subunit IIBC complement(1533846..1535363) Streptococcus pneumoniae G54 6479532 YP_002038298.1 CDS nanE NC_011072.1 1535382 1536080 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(1535382..1536080) Streptococcus pneumoniae G54 6480608 YP_002038299.1 CDS SPG_1594 NC_011072.1 1536254 1537357 R identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; match to protein family HMM PF03447; oxidoreductase complement(1536254..1537357) Streptococcus pneumoniae G54 6478977 YP_002038300.1 CDS nanB NC_011072.1 1537369 1539462 R identified by match to protein family HMM PF02012; match to protein family HMM PF02973; neuraminidase B complement(1537369..1539462) Streptococcus pneumoniae G54 6478703 YP_002038301.1 CDS SPG_1596 NC_011072.1 1539480 1540313 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1539480..1540313) Streptococcus pneumoniae G54 6478640 YP_002038302.1 CDS SPG_1597 NC_011072.1 1540313 1541197 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1540313..1541197) Streptococcus pneumoniae G54 6480007 YP_002038303.1 CDS SPG_1598 NC_011072.1 1541276 1542613 R identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein complement(1541276..1542613) Streptococcus pneumoniae G54 6479479 YP_002038304.1 CDS SPG_1599 NC_011072.1 1542632 1543084 R identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein complement(1542632..1543084) Streptococcus pneumoniae G54 6478808 YP_002038305.1 CDS nanA NC_011072.1 1544100 1546928 R identified by match to protein family HMM PF02012; match to protein family HMM PF02973; match to protein family HMM TIGR01167; neuraminidase A complement(1544100..1546928) Streptococcus pneumoniae G54 6479746 YP_002038306.1 CDS SPG_1601 NC_011072.1 1547286 1547513 R hypothetical protein complement(1547286..1547513) Streptococcus pneumoniae G54 6479987 YP_002038307.1 CDS axe1 NC_011072.1 1548408 1549388 R identified by match to protein family HMM PF05448; xylan esterase 1 complement(1548408..1549388) Streptococcus pneumoniae G54 6479347 YP_002038308.1 CDS recG NC_011072.1 1549704 1551719 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(1549704..1551719) Streptococcus pneumoniae G54 6480559 YP_002038309.1 CDS alr NC_011072.1 1551738 1552841 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(1551738..1552841) Streptococcus pneumoniae G54 6479457 YP_002038310.1 CDS acpS NC_011072.1 1552831 1553193 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(1552831..1553193) Streptococcus pneumoniae G54 6479104 YP_002038311.1 CDS SPG_1606 NC_011072.1 1553238 1554269 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1553238..1554269) Streptococcus pneumoniae G54 6479024 YP_002038312.1 CDS SPG_1607 NC_011072.1 1554271 1555302 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1554271..1555302) Streptococcus pneumoniae G54 6480293 YP_002038313.1 CDS secA NC_011072.1 1555383 1557896 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(1555383..1557896) Streptococcus pneumoniae G54 6478992 YP_002038314.1 CDS SPG_1609 NC_011072.1 1558042 1558329 R hypothetical protein complement(1558042..1558329) Streptococcus pneumoniae G54 6478669 YP_002038315.1 CDS SPG_1610 NC_011072.1 1558340 1558990 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1558340..1558990) Streptococcus pneumoniae G54 6480765 YP_002038316.1 CDS SPG_1611 NC_011072.1 1558994 1559635 R hypothetical protein complement(1558994..1559635) Streptococcus pneumoniae G54 6479248 YP_002038317.1 CDS SPG_1612 NC_011072.1 1559628 1560419 R identified by glimmer; putative; hypothetical protein complement(1559628..1560419) Streptococcus pneumoniae G54 6480319 YP_002038318.1 CDS SPG_1613 NC_011072.1 1560604 1560939 R hypothetical protein complement(1560604..1560939) Streptococcus pneumoniae G54 6479421 YP_002038319.1 CDS SPG_1614 NC_011072.1 1561079 1561414 R hypothetical protein complement(1561079..1561414) Streptococcus pneumoniae G54 6478798 YP_002038320.1 CDS engA NC_011072.1 1561502 1562812 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(1561502..1562812) Streptococcus pneumoniae G54 6480442 YP_002038321.1 CDS SPG_1616 NC_011072.1 1562826 1563539 R identified by match to protein family HMM PF00881; nitroreductase family protein complement(1562826..1563539) Streptococcus pneumoniae G54 6479590 YP_002038322.1 CDS SPG_1617 NC_011072.1 1563536 1564432 R Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI complement(1563536..1564432) Streptococcus pneumoniae G54 6480540 YP_002038323.1 CDS SPG_1618 NC_011072.1 1564433 1565602 R identified by glimmer; putative; hypothetical protein complement(1564433..1565602) Streptococcus pneumoniae G54 6480140 YP_002038324.1 CDS nrdR NC_011072.1 1565603 1566076 R identified by match to protein family HMM PF03477; match to protein family HMM TIGR00244; transcriptional regulator NrdR complement(1565603..1566076) Streptococcus pneumoniae G54 6479481 YP_002038325.1 CDS SPG_1620 NC_011072.1 1566216 1566581 D identified by match to protein family HMM PF00392; regulatory protein, GntR 1566216..1566581 Streptococcus pneumoniae G54 6480316 YP_002038326.1 CDS SPG_1621 NC_011072.1 1566586 1567281 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1566586..1567281 Streptococcus pneumoniae G54 6478821 YP_002038327.1 CDS SPG_1622 NC_011072.1 1567298 1568065 D ABC transporter ATP-binding protein 1567298..1568065 Streptococcus pneumoniae G54 6479258 YP_002038328.1 CDS SPG_1623 NC_011072.1 1568418 1569617 R ABC transporter permease complement(1568418..1569617) Streptococcus pneumoniae G54 6480734 YP_002038329.1 CDS SPG_1624 NC_011072.1 1569614 1570507 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1569614..1570507) Streptococcus pneumoniae G54 6479553 YP_002038330.1 CDS SPG_1625 NC_011072.1 1571817 1572434 D identified by match to protein family HMM PF09335; hypothetical protein 1571817..1572434 Streptococcus pneumoniae G54 6479662 YP_002038331.1 CDS SPG_1626 NC_011072.1 1572477 1573364 R identified by match to protein family HMM PF00480; fructokinase complement(1572477..1573364) Streptococcus pneumoniae G54 6479794 YP_002038332.1 CDS SPG_1627 NC_011072.1 1573513 1575396 R identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01996; PTS system transporter subunit IIBCA complement(1573513..1575396) Streptococcus pneumoniae G54 6480345 YP_002038333.1 CDS SPG_1628 NC_011072.1 1575523 1575720 R hypothetical protein complement(1575523..1575720) Streptococcus pneumoniae G54 6479280 YP_002038334.1 CDS SPG_1629 NC_011072.1 1575773 1577227 D identified by match to protein family HMM PF00251; match to protein family HMM PF08244; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase 1575773..1577227 Streptococcus pneumoniae G54 6480465 YP_002038335.1 CDS SPG_1630 NC_011072.1 1577208 1578173 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sucrose operon repressor 1577208..1578173 Streptococcus pneumoniae G54 6479127 YP_002038336.1 CDS mvaA NC_011072.1 1578208 1579482 R identified by match to protein family HMM TIGR00532; 3-hydroxy-3-methylglutaryl-coenzyme a reductase complement(1578208..1579482) Streptococcus pneumoniae G54 6480043 YP_002038337.1 CDS mvaS NC_011072.1 1579482 1580678 R Wilding, et. al. (2000) J. Bacteriol. 182, 4319-4327]; identified by match to protein family HMM PF01154; match to protein family HMM PF08540; match to protein family HMM TIGR01835; HMG-CoA synthase complement(1579482..1580678) Streptococcus pneumoniae G54 6479413 YP_002038338.1 CDS SPG_1633 NC_011072.1 1580785 1580982 R hypothetical protein complement(1580785..1580982) Streptococcus pneumoniae G54 6480728 YP_002038339.1 CDS SPG_1634 NC_011072.1 1581101 1581721 R identified by match to protein family HMM PF01609; transposase complement(1581101..1581721) Streptococcus pneumoniae G54 6478794 YP_002038340.1 CDS SPG_1635 NC_011072.1 1581786 1582235 R hypothetical protein complement(1581786..1582235) Streptococcus pneumoniae G54 6480069 YP_002038341.1 CDS SPG_1636 NC_011072.1 1582237 1582995 R identified by match to protein family HMM PF06738; hypothetical protein complement(1582237..1582995) Streptococcus pneumoniae G54 6480039 YP_002038342.1 CDS SPG_1637 NC_011072.1 1583110 1584741 R contains potential frameshift; identified by match to protein family HMM PF00069; match to protein family HMM PF03793; serine/threonine protein kinase complement(1583110..1584741) Streptococcus pneumoniae G54 6480741 YP_002038343.1 CDS SPG_1638 NC_011072.1 1584761 1585090 R contains potential frameshift; serine/threonine protein kinase complement(1584761..1585090) Streptococcus pneumoniae G54 6479788 YP_002038344.1 CDS SPG_1639 NC_011072.1 1585087 1585827 R identified by match to protein family HMM PF00481; protein phosphatase 2C complement(1585087..1585827) Streptococcus pneumoniae G54 6479382 YP_002038345.1 CDS sun NC_011072.1 1585842 1587155 R identified by match to protein family HMM PF01029; match to protein family HMM PF01189; match to protein family HMM TIGR00563; ribosomal RNA small subunit methyltransferase B complement(1585842..1587155) Streptococcus pneumoniae G54 6480631 YP_002038346.1 CDS fmt NC_011072.1 1587148 1588083 R modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase complement(1587148..1588083) Streptococcus pneumoniae G54 6479396 YP_002038347.1 CDS SPG_1642 NC_011072.1 1588096 1590492 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(1588096..1590492) Streptococcus pneumoniae G54 6479055 YP_002038348.1 CDS rpoZ NC_011072.1 1590558 1590869 R Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(1590558..1590869) Streptococcus pneumoniae G54 6480362 YP_002038349.1 CDS gmk NC_011072.1 1590897 1591523 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(1590897..1591523) Streptococcus pneumoniae G54 6480463 YP_002038350.1 CDS SPG_1645 NC_011072.1 1591653 1593266 R identified by match to protein family HMM PF00013; match to protein family HMM PF01966; match to protein family HMM TIGR00277; match to protein family HMM TIGR03319; hypothetical protein complement(1591653..1593266) Streptococcus pneumoniae G54 6479850 YP_002038351.1 CDS SPG_1646 NC_011072.1 1593610 1596357 R hypothetical protein complement(1593610..1596357) Streptococcus pneumoniae G54 6480745 YP_002038352.1 CDS SPG_1647 NC_011072.1 1596705 1597802 R identified by glimmer; putative; hypothetical protein complement(1596705..1597802) Streptococcus pneumoniae G54 6480206 YP_002038353.1 CDS SPG_1648 NC_011072.1 1597812 1598558 R identified by match to protein family HMM PF08241; match to protein family HMM PF08242; hypothetical protein complement(1597812..1598558) Streptococcus pneumoniae G54 6479161 YP_002038354.1 CDS SPG_1649 NC_011072.1 1598661 1599014 R identified by match to protein family HMM PF02410; match to protein family HMM TIGR00090; hypothetical protein complement(1598661..1599014) Streptococcus pneumoniae G54 6480567 YP_002038355.1 CDS SPG_1650 NC_011072.1 1599027 1599527 R isochorismatase family protein complement(1599027..1599527) Streptococcus pneumoniae G54 6479525 YP_002038356.1 CDS SPG_1651 NC_011072.1 1599528 1600121 R identified by match to protein family HMM PF01966; match to protein family HMM TIGR00488; hypothetical protein complement(1599528..1600121) Streptococcus pneumoniae G54 6479501 YP_002038357.1 CDS nadD NC_011072.1 1600121 1600750 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(1600121..1600750) Streptococcus pneumoniae G54 6480468 YP_002038358.1 CDS SPG_1653 NC_011072.1 1600802 1601113 R identified by match to protein family HMM PF01985; match to protein family HMM TIGR00253; hypothetical protein complement(1600802..1601113) Streptococcus pneumoniae G54 6480776 YP_002038359.1 CDS SPG_1654 NC_011072.1 1601327 1602433 R in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH complement(1601327..1602433) Streptococcus pneumoniae G54 6478880 YP_002038360.1 CDS SPG_1655 NC_011072.1 1602436 1602963 R identified by match to protein family HMM TIGR01662; match to protein family HMM TIGR01668; had-superfamily hydrolase (subfamily IIIa) phosphatase complement(1602436..1602963) Streptococcus pneumoniae G54 6480065 YP_002038361.1 CDS SPG_1656 NC_011072.1 1602978 1603886 R identified by match to protein family HMM PF01544; magnesium transporter, CorA family protein complement(1602978..1603886) Streptococcus pneumoniae G54 6479391 YP_002038362.1 CDS SPG_1657 NC_011072.1 1603943 1604503 R identified by match to protein family HMM PF00924; small conductance mechanosensitive ion channel family protein complement(1603943..1604503) Streptococcus pneumoniae G54 6479336 YP_002038363.1 CDS SPG_1658 NC_011072.1 1604707 1604865 D hypothetical protein 1604707..1604865 Streptococcus pneumoniae G54 6480488 YP_002038364.1 CDS SPG_1659 NC_011072.1 1604891 1605850 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 1604891..1605850 Streptococcus pneumoniae G54 6480192 YP_002038365.1 CDS SPG_1660 NC_011072.1 1605918 1606871 D identified by match to protein family HMM PF06081; hypothetical protein 1605918..1606871 Streptococcus pneumoniae G54 6478740 YP_002038366.1 CDS SPG_1661 NC_011072.1 1607016 1607396 D identified by match to protein family HMM PF01047; MarR family transcriptional regulator 1607016..1607396 Streptococcus pneumoniae G54 6480546 YP_002038367.1 CDS SPG_1662 NC_011072.1 1607495 1607716 D hypothetical protein 1607495..1607716 Streptococcus pneumoniae G54 6480124 YP_002038368.1 CDS trx NC_011072.1 1607733 1608047 D identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin 1607733..1608047 Streptococcus pneumoniae G54 6479238 YP_002038369.1 CDS SPG_1664 NC_011072.1 1608352 1608885 D NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 1608352..1608885 Streptococcus pneumoniae G54 6478724 YP_002038370.1 CDS SPG_1665 NC_011072.1 1609229 1609861 R identified by match to protein family HMM PF00230; aquaporin complement(1609229..1609861) Streptococcus pneumoniae G54 6479189 YP_002038371.1 CDS SPG_1666 NC_011072.1 1610007 1610798 R hypothetical protein complement(1610007..1610798) Streptococcus pneumoniae G54 6480791 YP_002038372.1 CDS SPG_1667 NC_011072.1 1610866 1611021 R identified by glimmer; putative; hypothetical protein complement(1610866..1611021) Streptococcus pneumoniae G54 6479935 YP_002038373.1 CDS SPG_1668 NC_011072.1 1611044 1612840 R identified by match to protein family HMM PF01432; match to protein family HMM PF08439; match to protein family HMM TIGR00181; oligoendopeptidase F complement(1611044..1612840) Streptococcus pneumoniae G54 6478812 YP_002038374.1 CDS SPG_1669 NC_011072.1 1612851 1613594 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(1612851..1613594) Streptococcus pneumoniae G54 6480676 YP_002038375.1 CDS SPG_1670 NC_011072.1 1613596 1613862 R contains potential frameshift; ribosomal protein L11 methyltransferase complement(1613596..1613862) Streptococcus pneumoniae G54 6479852 YP_002038376.1 CDS SPG_1671 NC_011072.1 1613855 1614550 R contains potential frameshift; identified by match to protein family HMM PF06325; ribosomal protein L11 methyltransferase complement(1613855..1614550) Streptococcus pneumoniae G54 6478736 YP_002038377.1 CDS SPG_1672 NC_011072.1 1614685 1615113 R identified by match to protein family HMM PF00293; MutT/nudix family protein complement(1614685..1615113) Streptococcus pneumoniae G54 6480569 YP_002038378.1 CDS SPG_1673 NC_011072.1 1615094 1616182 R identified by glimmer; putative; hypothetical protein complement(1615094..1616182) Streptococcus pneumoniae G54 6480537 YP_002038379.1 CDS SPG_1674 NC_011072.1 1616201 1616671 R identified by glimmer; putative; hypothetical protein complement(1616201..1616671) Streptococcus pneumoniae G54 6480082 YP_002038380.1 CDS SPG_1675 NC_011072.1 1616962 1617414 R identified by match to protein family HMM PF03681; hypothetical protein complement(1616962..1617414) Streptococcus pneumoniae G54 6480254 YP_002038381.1 CDS SPG_1676 NC_011072.1 1617451 1617630 R identified by match to protein family HMM PF07927; hypothetical protein complement(1617451..1617630) Streptococcus pneumoniae G54 6478690 YP_002038382.1 CDS SPG_1677 NC_011072.1 1617767 1617946 R hypothetical protein complement(1617767..1617946) Streptococcus pneumoniae G54 6479344 YP_002038383.1 CDS SPG_1678 NC_011072.1 1618150 1618350 R hypothetical protein complement(1618150..1618350) Streptococcus pneumoniae G54 6479005 YP_002038384.1 CDS SPG_1679 NC_011072.1 1618620 1619891 D identified by match to protein family HMM PF00004; recombination factor protein RarA 1618620..1619891 Streptococcus pneumoniae G54 6479752 YP_002038385.1 CDS SPG_1681 NC_011072.1 1620438 1621757 R identified by match to protein family HMM PF00251; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase complement(1620438..1621757) Streptococcus pneumoniae G54 6478980 YP_002038386.1 CDS SPG_1682 NC_011072.1 1621767 1622612 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1621767..1622612) Streptococcus pneumoniae G54 6479061 YP_002038387.1 CDS SPG_1683 NC_011072.1 1622614 1623516 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1622614..1623516) Streptococcus pneumoniae G54 6480126 YP_002038388.1 CDS SPG_1684 NC_011072.1 1623612 1624922 R identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein complement(1623612..1624922) Streptococcus pneumoniae G54 6479717 YP_002038389.1 CDS SPG_1685 NC_011072.1 1625050 1626045 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sucrose operon repressor complement(1625050..1626045) Streptococcus pneumoniae G54 6478933 YP_002038390.1 CDS mgrA NC_011072.1 1626407 1627888 R Hemsley, C.; 2003 J. Bact, 22:6640-6647; identified by match to protein family HMM PF05043; match to protein family HMM PF08270; match to protein family HMM PF08279; match to protein family HMM PF08280; Mga-like repressor A MgrA complement(1626407..1627888) Streptococcus pneumoniae G54 6478782 YP_002038391.1 CDS SPG_1687 NC_011072.1 1628331 1628495 D identified by match to protein family HMM PF04226; hypothetical protein 1628331..1628495 Streptococcus pneumoniae G54 6480284 YP_002038392.1 CDS SPG_1688 NC_011072.1 1628579 1629145 D hypothetical protein 1628579..1629145 Streptococcus pneumoniae G54 6480821 YP_002038393.1 CDS SPG_1689 NC_011072.1 1629157 1629327 D hypothetical protein 1629157..1629327 Streptococcus pneumoniae G54 6480248 YP_002038394.1 CDS SPG_1690 NC_011072.1 1629366 1629974 D identified by match to protein family HMM PF03780; hypothetical protein 1629366..1629974 Streptococcus pneumoniae G54 6479236 YP_002038395.1 CDS SPG_1691 NC_011072.1 1630005 1630208 D identified by match to protein family HMM PF05532; hypothetical protein 1630005..1630208 Streptococcus pneumoniae G54 6480493 YP_002038396.1 CDS SPG_1692 NC_011072.1 1631022 1631141 R identified by glimmer; putative; hypothetical protein complement(1631022..1631141) Streptococcus pneumoniae G54 6479144 YP_002038397.1 CDS SPG_1693 NC_011072.1 1631359 1632129 R identified by glimmer; putative; hypothetical protein complement(1631359..1632129) Streptococcus pneumoniae G54 6480510 YP_002038398.1 CDS SPG_1694 NC_011072.1 1632144 1632770 R identified by match to protein family HMM PF03781; hypothetical protein complement(1632144..1632770) Streptococcus pneumoniae G54 6479271 YP_002038399.1 CDS SPG_1695 NC_011072.1 1632676 1633026 R contains potential frameshift; PTS system transporter subunit IIC complement(1632676..1633026) Streptococcus pneumoniae G54 6479466 YP_002038400.1 CDS SPG_1696 NC_011072.1 1632980 1633279 R contains potential frameshift; PTS system transporter subunit IIC complement(1632980..1633279) Streptococcus pneumoniae G54 6479909 YP_002038401.1 CDS SPG_1697 NC_011072.1 1633289 1633606 R identified by match to protein family HMM PF02255; PTS system transporter subunit IIA complement(1633289..1633606) Streptococcus pneumoniae G54 6479922 YP_002038402.1 CDS SPG_1698 NC_011072.1 1633623 1633940 R identified by match to protein family HMM PF02302; PTS system transporter subunit IIB complement(1633623..1633940) Streptococcus pneumoniae G54 6479420 YP_002038403.1 CDS SPG_1699 NC_011072.1 1633955 1634557 R contains potential frameshift; hypothetical protein complement(1633955..1634557) Streptococcus pneumoniae G54 6479432 YP_002038404.1 CDS SPG_1700 NC_011072.1 1634544 1634852 R contains potential frameshift; hypothetical protein complement(1634544..1634852) Streptococcus pneumoniae G54 6479810 YP_002038405.1 CDS SPG_1701 NC_011072.1 1634855 1636117 R identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; PTS system transporter subunit IIC complement(1634855..1636117) Streptococcus pneumoniae G54 6480368 YP_002038406.1 CDS SPG_1702 NC_011072.1 1636397 1637575 D identified by match to protein family HMM PF00480; transcriptional regulator/sugar kinase 1636397..1637575 Streptococcus pneumoniae G54 6479513 YP_002038407.1 CDS SPG_1703 NC_011072.1 1637803 1638249 R identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1637803..1638249) Streptococcus pneumoniae G54 6479097 YP_002038408.1 CDS SPG_1704 NC_011072.1 1638319 1638978 D identified by match to protein family HMM PF01478; match to protein family HMM PF06750; type 4 prepilin peptidase 1638319..1638978 Streptococcus pneumoniae G54 6479930 YP_002038409.1 CDS SPG_1705 NC_011072.1 1639030 1640181 R identified by match to protein family HMM PF01381; match to protein family HMM PF06114; transcriptional regulator complement(1639030..1640181) Streptococcus pneumoniae G54 6479434 YP_002038410.1 CDS SPG_1706 NC_011072.1 1640196 1640927 R hypothetical protein complement(1640196..1640927) Streptococcus pneumoniae G54 6480377 YP_002038411.1 CDS trpA NC_011072.1 1641229 1642005 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1641229..1642005) Streptococcus pneumoniae G54 6479832 YP_002038412.1 CDS trpB NC_011072.1 1641998 1643221 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1641998..1643221) Streptococcus pneumoniae G54 6480424 YP_002038413.1 CDS trpF NC_011072.1 1643199 1643798 R catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase complement(1643199..1643798) Streptococcus pneumoniae G54 6479550 YP_002038414.1 CDS trpC NC_011072.1 1643785 1644552 R involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase complement(1643785..1644552) Streptococcus pneumoniae G54 6478899 YP_002038415.1 CDS trpD NC_011072.1 1644549 1645553 R Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase complement(1644549..1645553) Streptococcus pneumoniae G54 6480598 YP_002038416.1 CDS trpG NC_011072.1 1645564 1646130 R TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II complement(1645564..1646130) Streptococcus pneumoniae G54 6480379 YP_002038417.1 CDS trpE NC_011072.1 1646127 1647488 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1646127..1647488) Streptococcus pneumoniae G54 6478993 YP_002038418.1 CDS SPG_1714 NC_011072.1 1648809 1649810 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; LacI family transcriptional regulator complement(1648809..1649810) Streptococcus pneumoniae G54 6480409 YP_002038419.1 CDS SPG_1715 NC_011072.1 1650382 1651092 R identified by match to protein family HMM PF02308; hypothetical protein complement(1650382..1651092) Streptococcus pneumoniae G54 6480195 YP_002038420.1 CDS SPG_1716 NC_011072.1 1651095 1652786 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1651095..1652786) Streptococcus pneumoniae G54 6479837 YP_002038421.1 CDS SPG_1717 NC_011072.1 1652798 1653808 R identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; ABC transporter ATP-binding protein complement(1652798..1653808) Streptococcus pneumoniae G54 6479096 YP_002038422.1 CDS SPG_1718 NC_011072.1 1653912 1654979 R ABC transporter substrate-binding protein complement(1653912..1654979) Streptococcus pneumoniae G54 6479872 YP_002038423.1 CDS SPG_1719 NC_011072.1 1655004 1655663 R identified by match to protein family HMM PF08975; hypothetical protein complement(1655004..1655663) Streptococcus pneumoniae G54 6479392 YP_002038424.1 CDS SPG_1720 NC_011072.1 1656685 1658811 R identified by glimmer; putative; hypothetical protein complement(1656685..1658811) Streptococcus pneumoniae G54 6480816 YP_002038425.1 CDS SPG_1721 NC_011072.1 1659974 1661200 R identified by match to protein family HMM PF01041; capsular polysaccharide biosynthesis protein complement(1659974..1661200) Streptococcus pneumoniae G54 6479146 YP_002038426.1 CDS SPG_1722 NC_011072.1 1661243 1661935 R identified by match to protein family HMM PF02397; glycosyl transferase complement(1661243..1661935) Streptococcus pneumoniae G54 6479349 YP_002038427.1 CDS SPG_1723 NC_011072.1 1662108 1663859 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding/permease complement(1662108..1663859) Streptococcus pneumoniae G54 6479148 YP_002038428.1 CDS SPG_1724 NC_011072.1 1663849 1665594 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding/permease complement(1663849..1665594) Streptococcus pneumoniae G54 6479218 YP_002038429.1 CDS SPG_1725 NC_011072.1 1665800 1666177 R identified by match to protein family HMM PF04239; hypothetical protein complement(1665800..1666177) Streptococcus pneumoniae G54 6480511 YP_002038430.1 CDS SPG_1726 NC_011072.1 1666249 1666518 R hypothetical protein complement(1666249..1666518) Streptococcus pneumoniae G54 6480542 YP_002038431.1 CDS SPG_1727 NC_011072.1 1666478 1666705 R hypothetical protein complement(1666478..1666705) Streptococcus pneumoniae G54 6478874 YP_002038432.1 CDS exoA NC_011072.1 1666839 1667666 D identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633; exodeoxyribonuclease III 1666839..1667666 Streptococcus pneumoniae G54 6480240 YP_002038433.1 CDS SPG_1729 NC_011072.1 1667678 1667821 D hypothetical protein 1667678..1667821 Streptococcus pneumoniae G54 6479616 YP_002038434.1 CDS SPG_1730 NC_011072.1 1667932 1668060 D identified by glimmer; putative; hypothetical protein 1667932..1668060 Streptococcus pneumoniae G54 6479195 YP_002038435.1 CDS xpt NC_011072.1 1668938 1669519 D Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 1668938..1669519 Streptococcus pneumoniae G54 6480270 YP_002038436.1 CDS SPG_1732 NC_011072.1 1669519 1670781 D identified by match to protein family HMM PF00860; match to protein family HMM PF00916; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173; xanthine permease 1669519..1670781 Streptococcus pneumoniae G54 6479155 YP_002038437.1 CDS dpnB NC_011072.1 1670868 1671734 R Lacks,S.; J. Mol. Biol. 250 (2), 144-155 (1995); identified by match to protein family HMM PF04556; DpnII endonuclease complement(1670868..1671734) Streptococcus pneumoniae G54 6478882 YP_002038438.1 CDS dpnA NC_011072.1 1671721 1672491 R Lacks,S.; J. Mol. Biol. 250 (2), 144-155 (1995); identified by match to protein family HMM PF01555; DNA adenine methyltransferase DpnII complement(1671721..1672491) Streptococcus pneumoniae G54 6480253 YP_002038439.1 CDS dpnM NC_011072.1 1672517 1673371 R Lacks,S.; J. Mol. Biol. 250 (2), 144-155 (1995); identified by match to protein family HMM PF02086; match to protein family HMM TIGR00571; DNA adenine methyltransferase DpnII complement(1672517..1673371) Streptococcus pneumoniae G54 6480075 YP_002038440.1 CDS SPG_1736 NC_011072.1 1673528 1673932 R identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; hypothetical protein complement(1673528..1673932) Streptococcus pneumoniae G54 6480164 YP_002038441.1 CDS SPG_1737 NC_011072.1 1674002 1675483 R catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase complement(1674002..1675483) Streptococcus pneumoniae G54 6478868 YP_002038442.1 CDS SPG_1738 NC_011072.1 1675502 1676680 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(1675502..1676680) Streptococcus pneumoniae G54 6480580 YP_002038443.1 CDS SPG_1739 NC_011072.1 1676844 1677851 D identified by match to protein family HMM PF00356; galactose operon repressor 1676844..1677851 Streptococcus pneumoniae G54 6480785 YP_002038444.1 CDS SPG_1740 NC_011072.1 1677898 1678341 R contains potential frameshift; alcohol dehydrogenase complement(1677898..1678341) Streptococcus pneumoniae G54 6480250 YP_002038445.1 CDS SPG_1741 NC_011072.1 1678338 1678937 R contains potential frameshift; identified by match to protein family HMM PF08240; alcohol dehydrogenase complement(1678338..1678937) Streptococcus pneumoniae G54 6480138 YP_002038446.1 CDS SPG_1742 NC_011072.1 1678938 1679291 R identified by match to protein family HMM PF00376; MerR family transcriptional regulator complement(1678938..1679291) Streptococcus pneumoniae G54 6479622 YP_002038447.1 CDS SPG_1743 NC_011072.1 1679535 1680425 R identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation efflux family protein complement(1679535..1680425) Streptococcus pneumoniae G54 6478886 YP_002038448.1 CDS SPG_1744 NC_011072.1 1680558 1681094 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 1680558..1681094 Streptococcus pneumoniae G54 6478998 YP_002038449.1 CDS SPG_1745 NC_011072.1 1681260 1682066 R identified by match to protein family HMM PF04973; match to protein family HMM TIGR01528; nicotinamide mononucleotide transporter PnuC complement(1681260..1682066) Streptococcus pneumoniae G54 6479770 YP_002038450.1 CDS SPG_1746 NC_011072.1 1682411 1683931 R identified by match to protein family HMM PF00528; match to protein family HMM PF04069; ABC transporter substrate-binding/permease complement(1682411..1683931) Streptococcus pneumoniae G54 6480662 YP_002038451.1 CDS SPG_1747 NC_011072.1 1683924 1684652 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1683924..1684652) Streptococcus pneumoniae G54 6479222 YP_002038452.1 CDS SPG_1748 NC_011072.1 1684667 1685431 R identified by match to protein family HMM PF07366; hypothetical protein complement(1684667..1685431) Streptococcus pneumoniae G54 6479253 YP_002038453.1 CDS SPG_1749 NC_011072.1 1685435 1685878 R identified by match to protein family HMM PF01047; MarR family transcriptional regulator complement(1685435..1685878) Streptococcus pneumoniae G54 6479060 YP_002038454.1 CDS SPG_1750 NC_011072.1 1686560 1686856 R identified by match to protein family HMM PF08957; hypothetical protein complement(1686560..1686856) Streptococcus pneumoniae G54 6480570 YP_002038455.1 CDS SPG_1751 NC_011072.1 1686878 1687942 R identified by match to protein family HMM PF05343; match to protein family HMM TIGR03107; glutamyl aminopeptidase complement(1686878..1687942) Streptococcus pneumoniae G54 6480388 YP_002038456.1 CDS SPG_1752 NC_011072.1 1688062 1688184 D identified by glimmer; putative; hypothetical protein 1688062..1688184 Streptococcus pneumoniae G54 6478689 YP_002038457.1 CDS SPG_1753 NC_011072.1 1688343 1689044 D identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993; NAD dependent epimerase/dehydratase family protein 1688343..1689044 Streptococcus pneumoniae G54 6479140 YP_002038458.1 CDS SPG_1754 NC_011072.1 1689467 1690426 D identified by match to protein family HMM PF01032; ABC transporter permease 1689467..1690426 Streptococcus pneumoniae G54 6480056 YP_002038459.1 CDS SPG_1755 NC_011072.1 1690416 1691372 D identified by match to protein family HMM PF01032; ABC transporter permease 1690416..1691372 Streptococcus pneumoniae G54 6480215 YP_002038460.1 CDS SPG_1756 NC_011072.1 1691369 1692121 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1691369..1692121 Streptococcus pneumoniae G54 6479011 YP_002038461.1 CDS SPG_1757 NC_011072.1 1692217 1693182 D identified by match to protein family HMM PF01497; ABC transporter substrate binding protein 1692217..1693182 Streptococcus pneumoniae G54 6479646 YP_002038462.1 CDS SPG_1758 NC_011072.1 1693407 1693649 R identified by match to protein family HMM PF01809; match to protein family HMM TIGR00278; hypothetical protein complement(1693407..1693649) Streptococcus pneumoniae G54 6480712 YP_002038463.1 CDS SPG_1759 NC_011072.1 1693649 1694371 R identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal large subunit pseudouridine synthase B complement(1693649..1694371) Streptococcus pneumoniae G54 6479284 YP_002038464.1 CDS scpB NC_011072.1 1694358 1694927 R functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B complement(1694358..1694927) Streptococcus pneumoniae G54 6480242 YP_002038465.1 CDS scpA NC_011072.1 1694946 1695674 R functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A complement(1694946..1695674) Streptococcus pneumoniae G54 6480622 YP_002038466.1 CDS xerD NC_011072.1 1695674 1696414 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD-like protein complement(1695674..1696414) Streptococcus pneumoniae G54 6479459 YP_002038467.1 CDS SPG_1763 NC_011072.1 1696405 1696866 R identified by match to protein family HMM PF00571; hypothetical protein complement(1696405..1696866) Streptococcus pneumoniae G54 6479360 YP_002038468.1 CDS SPG_1764 NC_011072.1 1696863 1697384 R identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040; hypothetical protein complement(1696863..1697384) Streptococcus pneumoniae G54 6479745 YP_002038469.1 CDS SPG_1765 NC_011072.1 1697360 1698331 R HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative fused deoxyribonucleotide triphosphate pyrophosphatase/unknown domain protein complement(1697360..1698331) Streptococcus pneumoniae G54 6480430 YP_002038470.1 CDS murI NC_011072.1 1698328 1699122 R converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase complement(1698328..1699122) Streptococcus pneumoniae G54 6479463 YP_002038471.1 CDS SPG_1767 NC_011072.1 1699329 1699577 R hypothetical protein complement(1699329..1699577) Streptococcus pneumoniae G54 6479074 YP_002038472.1 CDS treC NC_011072.1 1699833 1701458 R identified by match to protein family HMM PF00128; match to protein family HMM TIGR02403; alpha,alpha-phosphotrehalase complement(1699833..1701458) Streptococcus pneumoniae G54 6480257 YP_002038473.1 CDS SPG_1769 NC_011072.1 1701636 1703603 R identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01992; PTS system transporter subunit IIBCA complement(1701636..1703603) Streptococcus pneumoniae G54 6480117 YP_002038474.1 CDS SPG_1770 NC_011072.1 1703788 1704498 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM TIGR02404; transcriptional repressor 1703788..1704498 Streptococcus pneumoniae G54 6480782 YP_002038475.1 CDS SPG_1771 NC_011072.1 1704653 1704889 D IS1167 transposase 1704653..1704889 Streptococcus pneumoniae G54 6479385 YP_002038476.1 CDS SPG_1772 NC_011072.1 1704914 1705171 D IS1167 transposase 1704914..1705171 Streptococcus pneumoniae G54 6479452 YP_002038477.1 CDS SPG_1773 NC_011072.1 1705452 1705979 D IS1167 transposase 1705452..1705979 Streptococcus pneumoniae G54 6480483 YP_002038478.1 CDS SPG_1774 NC_011072.1 1706054 1706980 R identified by match to protein family HMM PF00005; match to protein family HMM PF08352; ABC transporter ATP-binding protein complement(1706054..1706980) Streptococcus pneumoniae G54 6479511 YP_002038479.1 CDS SPG_1775 NC_011072.1 1706991 1708058 R identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; ABC transporter ATP-binding protein complement(1706991..1708058) Streptococcus pneumoniae G54 6479940 YP_002038480.1 CDS SPG_1776 NC_011072.1 1708067 1708993 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1708067..1708993) Streptococcus pneumoniae G54 6480047 YP_002038481.1 CDS SPG_1777 NC_011072.1 1708993 1710489 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1708993..1710489) Streptococcus pneumoniae G54 6479004 YP_002038482.1 CDS SPG_1778 NC_011072.1 1710556 1712535 R identified by match to protein family HMM PF00496; ABC transporter substrate binding protein complement(1710556..1712535) Streptococcus pneumoniae G54 6479981 YP_002038483.1 CDS SPG_1779 NC_011072.1 1713014 1714360 D identified by match to protein family HMM PF01609; IS1380-Spn1 transposase 1713014..1714360 Streptococcus pneumoniae G54 6479609 YP_002038484.1 CDS SPG_1780 NC_011072.1 1714930 1716123 R identified by glimmer; putative; hypothetical protein complement(1714930..1716123) Streptococcus pneumoniae G54 6478770 YP_002038485.1 CDS SPG_1781 NC_011072.1 1716261 1717703 R identified by match to protein family HMM PF00128; sucrose phosphorylase complement(1716261..1717703) Streptococcus pneumoniae G54 6479301 YP_002038486.1 CDS SPG_1782 NC_011072.1 1718061 1718894 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1718061..1718894) Streptococcus pneumoniae G54 6479216 YP_002038487.1 CDS SPG_1783 NC_011072.1 1718908 1719774 R identified by match to protein family HMM PF00528; ABC transporter ATP-binding/permease complement(1718908..1719774) Streptococcus pneumoniae G54 6480077 YP_002038488.1 CDS SPG_1784 NC_011072.1 1719788 1721047 R identified by match to protein family HMM PF01547; ABC transporter sugar-binding protein complement(1719788..1721047) Streptococcus pneumoniae G54 6480249 YP_002038489.1 CDS SPG_1785 NC_011072.1 1721139 1723301 R identified by match to protein family HMM PF02065; alpha-galactosidase AgaN complement(1721139..1723301) Streptococcus pneumoniae G54 6480104 YP_002038490.1 CDS msmR NC_011072.1 1723409 1724269 D identified by match to protein family HMM PF00165; match to protein family HMM PF02311; msm operon regulatory protein 1723409..1724269 Streptococcus pneumoniae G54 6480692 YP_002038491.1 CDS birA NC_011072.1 1724266 1725201 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1724266..1725201 Streptococcus pneumoniae G54 6480295 YP_002038492.1 CDS SPG_1810 NC_011072.1 1732106 1733461 R contains potential frameshift; identified by match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA complement(1732106..1733461) Streptococcus pneumoniae G54 6480454 YP_002038493.1 CDS recX NC_011072.1 1733499 1734275 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1733499..1734275 Streptococcus pneumoniae G54 6478765 YP_002038494.1 CDS SPG_1812 NC_011072.1 1734364 1734897 D identified by match to protein family HMM PF04167; hypothetical protein 1734364..1734897 Streptococcus pneumoniae G54 6479825 YP_002038495.1 CDS SPG_1813 NC_011072.1 1735253 1735459 R hypothetical protein complement(1735253..1735459) Streptococcus pneumoniae G54 6480470 YP_002038496.1 CDS SPG_1814 NC_011072.1 1735771 1736109 R identified by match to protein family HMM PF01381; transcriptional regulator complement(1735771..1736109) Streptococcus pneumoniae G54 6478775 YP_002038497.1 CDS SPG_1815 NC_011072.1 1736122 1736895 R identified by match to protein family HMM PF08241; match to protein family HMM PF08242; hypothetical protein complement(1736122..1736895) Streptococcus pneumoniae G54 6479497 YP_002038498.1 CDS SPG_1816 NC_011072.1 1737422 1737673 R hypothetical protein complement(1737422..1737673) Streptococcus pneumoniae G54 6480587 YP_002038499.1 CDS SPG_1817 NC_011072.1 1737767 1737976 R hypothetical protein complement(1737767..1737976) Streptococcus pneumoniae G54 6479251 YP_002038500.1 CDS groEL NC_011072.1 1738234 1739856 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL complement(1738234..1739856) Streptococcus pneumoniae G54 6478879 YP_002038501.1 CDS groES NC_011072.1 1739872 1740156 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(1739872..1740156) Streptococcus pneumoniae G54 6479520 YP_002038502.1 CDS ssb NC_011072.1 1740426 1740821 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1740426..1740821) Streptococcus pneumoniae G54 6480496 YP_002038503.1 CDS SPG_1821 NC_011072.1 1740899 1741660 R identified by match to protein family HMM PF00106; short chain dehydrogenase/reductase family oxidoreductase complement(1740899..1741660) Streptococcus pneumoniae G54 6479737 YP_002038504.1 CDS SPG_1822 NC_011072.1 1741693 1742319 R identified by match to protein family HMM PF01588; hypothetical protein complement(1741693..1742319) Streptococcus pneumoniae G54 6479172 YP_002038505.1 CDS SPG_1823 NC_011072.1 1742335 1742652 R identified by match to protein family HMM PF00085; thioredoxin family protein complement(1742335..1742652) Streptococcus pneumoniae G54 6479176 YP_002038506.1 CDS SPG_1824 NC_011072.1 1742649 1742939 R hypothetical protein complement(1742649..1742939) Streptococcus pneumoniae G54 6480150 YP_002038507.1 CDS SPG_1825 NC_011072.1 1743233 1743376 R identified by match to protein family HMM PF01473; hypothetical protein complement(1743233..1743376) Streptococcus pneumoniae G54 6479443 YP_002038508.1 CDS SPG_1826 NC_011072.1 1743585 1744259 R hypothetical protein complement(1743585..1744259) Streptococcus pneumoniae G54 6480518 YP_002038509.1 CDS SPG_1827 NC_011072.1 1744265 1744711 R identified by match to protein family HMM PF04397; LytTr DNA-binding domain-containing protein complement(1744265..1744711) Streptococcus pneumoniae G54 6480696 YP_002038510.1 CDS SPG_1828 NC_011072.1 1744825 1745328 R identified by match to protein family HMM PF01569; hypothetical protein complement(1744825..1745328) Streptococcus pneumoniae G54 6480170 YP_002038511.1 CDS SPG_1829 NC_011072.1 1745325 1745687 R hypothetical protein complement(1745325..1745687) Streptococcus pneumoniae G54 6479702 YP_002038512.1 CDS SPG_1830 NC_011072.1 1745753 1746784 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1745753..1746784) Streptococcus pneumoniae G54 6479983 YP_002038513.1 CDS SPG_1831 NC_011072.1 1746791 1747168 R ABC transporter permease complement(1746791..1747168) Streptococcus pneumoniae G54 6480383 YP_002038514.1 CDS SPG_1832 NC_011072.1 1747184 1747612 R ABC transporter permease complement(1747184..1747612) Streptococcus pneumoniae G54 6478766 YP_002038515.1 CDS SPG_1833 NC_011072.1 1747651 1747950 R transcriptional regulator complement(1747651..1747950) Streptococcus pneumoniae G54 6479110 YP_002038516.1 CDS SPG_1834 NC_011072.1 1747963 1748100 R transcriptional regulator complement(1747963..1748100) Streptococcus pneumoniae G54 6479342 YP_002038517.1 CDS SPG_1835 NC_011072.1 1748224 1748940 R identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein complement(1748224..1748940) Streptococcus pneumoniae G54 6478983 YP_002038518.1 CDS ply NC_011072.1 1749821 1751236 R identified by match to protein family HMM PF01289; pneumolysin complement(1749821..1751236) Streptococcus pneumoniae G54 6479683 YP_002038519.1 CDS SPG_1837 NC_011072.1 1751247 1751579 R hypothetical protein complement(1751247..1751579) Streptococcus pneumoniae G54 6479076 YP_002038520.1 CDS SPG_1838 NC_011072.1 1751650 1752258 R hypothetical protein complement(1751650..1752258) Streptococcus pneumoniae G54 6479124 YP_002038521.1 CDS SPG_1839 NC_011072.1 1752271 1752729 R hypothetical protein complement(1752271..1752729) Streptococcus pneumoniae G54 6478907 YP_002038522.1 CDS SPG_1840 NC_011072.1 1752854 1753657 D identified by match to protein family HMM PF01609; transposase 1752854..1753657 Streptococcus pneumoniae G54 6479854 YP_002038523.1 CDS SPG_1841 NC_011072.1 1754395 1754655 R hypothetical protein complement(1754395..1754655) Streptococcus pneumoniae G54 6479378 YP_002038524.1 CDS SPG_1842 NC_011072.1 1754714 1755265 R hypothetical protein complement(1754714..1755265) Streptococcus pneumoniae G54 6479044 YP_002038525.1 CDS SPG_1843 NC_011072.1 1755255 1756250 R hypothetical protein complement(1755255..1756250) Streptococcus pneumoniae G54 6479037 YP_002038526.1 CDS SPG_1844 NC_011072.1 1756658 1757083 R hypothetical protein complement(1756658..1757083) Streptococcus pneumoniae G54 6479308 YP_002038527.1 CDS SPG_1845 NC_011072.1 1757212 1757571 R hypothetical protein complement(1757212..1757571) Streptococcus pneumoniae G54 6479727 YP_002038528.1 CDS SPG_1846 NC_011072.1 1757810 1757971 R type II restriction-modification system regulatory protein complement(1757810..1757971) Streptococcus pneumoniae G54 6478748 YP_002038529.1 CDS lytA NC_011072.1 1758317 1759273 R identified by match to protein family HMM PF01473; match to protein family HMM PF01510; autolysin complement(1758317..1759273) Streptococcus pneumoniae G54 6480363 YP_002038530.1 CDS SPG_1848 NC_011072.1 1759649 1761019 R identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; MATE efflux family protein complement(1759649..1761019) Streptococcus pneumoniae G54 6479472 YP_002038531.1 CDS recA NC_011072.1 1761326 1762492 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(1761326..1762492) Streptococcus pneumoniae G54 6480620 YP_002038532.1 CDS SPG_1850 NC_011072.1 1762547 1763803 R identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; competence damage-inducible protein A complement(1762547..1763803) Streptococcus pneumoniae G54 6478649 YP_002038533.1 CDS SPG_1851 NC_011072.1 1763888 1764904 R identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; transcriptional regulator complement(1763888..1764904) Streptococcus pneumoniae G54 6480265 YP_002038534.1 CDS SPG_1852 NC_011072.1 1764912 1765430 R identified by match to protein family HMM PF00583; GNAT family acetyltransferase complement(1764912..1765430) Streptococcus pneumoniae G54 6479568 YP_002038535.1 CDS SPG_1853 NC_011072.1 1765420 1765863 R identified by match to protein family HMM PF02367; match to protein family HMM TIGR00150; hypothetical protein complement(1765420..1765863) Streptococcus pneumoniae G54 6479773 YP_002038536.1 CDS SPG_1854 NC_011072.1 1765949 1766569 R identified by glimmer; putative; hypothetical protein complement(1765949..1766569) Streptococcus pneumoniae G54 6478727 YP_002038537.1 CDS SPG_1855 NC_011072.1 1766952 1767815 R identified by match to protein family HMM PF01381; transcriptional activator complement(1766952..1767815) Streptococcus pneumoniae G54 6480394 YP_002038538.1 CDS SPG_1856 NC_011072.1 1768487 1768783 D identified by glimmer; putative; hypothetical protein 1768487..1768783 Streptococcus pneumoniae G54 6478909 YP_002038539.1 CDS SPG_1857 NC_011072.1 1768886 1770901 D identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; hypothetical protein 1768886..1770901 Streptococcus pneumoniae G54 6479510 YP_002038540.1 CDS SPG_1858 NC_011072.1 1770903 1771535 D identified by match to protein family HMM PF00005; match to protein family HMM TIGR03608; ABC transporter ATP-binding protein 1770903..1771535 Streptococcus pneumoniae G54 6480666 YP_002038541.1 CDS SPG_1859 NC_011072.1 1771676 1771954 D hypothetical protein 1771676..1771954 Streptococcus pneumoniae G54 6479419 YP_002038542.1 CDS ndk NC_011072.1 1772464 1772877 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(1772464..1772877) Streptococcus pneumoniae G54 6479809 YP_002038543.1 CDS rpoC NC_011072.1 1772988 1776665 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(1772988..1776665) Streptococcus pneumoniae G54 6480071 YP_002038544.1 CDS rpoB NC_011072.1 1776698 1780309 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(1776698..1780309) Streptococcus pneumoniae G54 6479938 YP_002038545.1 CDS SPG_1864 NC_011072.1 1780993 1782324 R identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471; CBS domain membrane protein complement(1780993..1782324) Streptococcus pneumoniae G54 6479583 YP_002038546.1 CDS SPG_1865 NC_011072.1 1782615 1783439 R identified by match to protein family HMM PF01223; DNA-entry nuclease complement(1782615..1783439) Streptococcus pneumoniae G54 6479370 YP_002038547.1 CDS SPG_1866 NC_011072.1 1783478 1783666 R hypothetical protein complement(1783478..1783666) Streptococcus pneumoniae G54 6480033 YP_002038548.1 CDS murA2 NC_011072.1 1783659 1784942 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(1783659..1784942) Streptococcus pneumoniae G54 6479489 YP_002038549.1 CDS SPG_1868 NC_011072.1 1784966 1785196 R identified by glimmer; putative; hypothetical protein complement(1784966..1785196) Streptococcus pneumoniae G54 6478945 YP_002038550.1 CDS SPG_1869 NC_011072.1 1785254 1786291 R hypothetical protein complement(1785254..1786291) Streptococcus pneumoniae G54 6479670 YP_002038551.1 CDS coaD NC_011072.1 1786275 1786763 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(1786275..1786763) Streptococcus pneumoniae G54 6479937 YP_002038552.1 CDS SPG_1871 NC_011072.1 1786753 1787292 R identified by match to protein family HMM PF03602; match to protein family HMM TIGR00095; type II DNA modification methyltransferase complement(1786753..1787292) Streptococcus pneumoniae G54 6478895 YP_002038553.1 CDS asnA NC_011072.1 1787357 1788349 R catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA complement(1787357..1788349) Streptococcus pneumoniae G54 6478674 YP_002038554.1 CDS SPG_1873 NC_011072.1 1788462 1789145 R identified by match to protein family HMM PF01027; hypothetical protein complement(1788462..1789145) Streptococcus pneumoniae G54 6479891 YP_002038555.1 CDS SPG_1874 NC_011072.1 1789201 1789461 R contains potential frameshift; identified by match to protein family HMM PF00588; rRNA/tRNA methylase complement(1789201..1789461) Streptococcus pneumoniae G54 6480342 YP_002038556.1 CDS SPG_1875 NC_011072.1 1789548 1789940 R contains potential frameshift; identified by match to protein family HMM PF08032; rRNA/tRNA methylase complement(1789548..1789940) Streptococcus pneumoniae G54 6480191 YP_002038557.1 CDS SPG_1876 NC_011072.1 1789974 1790252 D catalyzes the hydrolysis of acylphosphate; acylphosphatase 1789974..1790252 Streptococcus pneumoniae G54 6480674 YP_002038558.1 CDS SPG_1877 NC_011072.1 1790330 1791256 D involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor 1790330..1791256 Streptococcus pneumoniae G54 6479111 YP_002038559.1 CDS pflA NC_011072.1 1791331 1792125 R identified by match to protein family HMM PF04055; match to protein family HMM TIGR02493; pyruvate formate-lyase 1-activating enzyme complement(1791331..1792125) Streptococcus pneumoniae G54 6480151 YP_002038560.1 CDS lysA NC_011072.1 1792251 1793501 R identified by match to protein family HMM PF00278; match to protein family HMM PF02784; diaminopimelate decarboxylase complement(1792251..1793501) Streptococcus pneumoniae G54 6479815 YP_002038561.1 CDS purR NC_011072.1 1793568 1794395 R identified by match to protein family HMM PF00156; match to protein family HMM PF09182; match to protein family HMM TIGR01743; pur operon repressor complement(1793568..1794395) Streptococcus pneumoniae G54 6479954 YP_002038562.1 CDS SPG_1881 NC_011072.1 1794662 1795603 R identified by match to protein family HMM PF01336; cmp-binding-factor 1 complement(1794662..1795603) Streptococcus pneumoniae G54 6479106 YP_002038563.1 CDS SPG_1882 NC_011072.1 1795593 1796849 R identified by match to protein family HMM PF02646; hypothetical protein complement(1795593..1796849) Streptococcus pneumoniae G54 6479141 YP_002038564.1 CDS SPG_1883 NC_011072.1 1796851 1797513 R identified by match to protein family HMM PF04263; match to protein family HMM PF04265; match to protein family HMM TIGR01378; Thiamine pyrophosphokinase complement(1796851..1797513) Streptococcus pneumoniae G54 6480577 YP_002038565.1 CDS rpe NC_011072.1 1797476 1798132 R identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163; ribulose-phosphate 3-epimerase complement(1797476..1798132) Streptococcus pneumoniae G54 6479704 YP_002038566.1 CDS SPG_1885 NC_011072.1 1798143 1799021 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(1798143..1799021) Streptococcus pneumoniae G54 6479993 YP_002038567.1 CDS ksgA NC_011072.1 1799023 1799895 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(1799023..1799895) Streptococcus pneumoniae G54 6478731 YP_002038568.1 CDS SPG_1887 NC_011072.1 1800026 1800334 R hypothetical protein complement(1800026..1800334) Streptococcus pneumoniae G54 6480119 YP_002038569.1 CDS SPG_1888 NC_011072.1 1800327 1800968 R identified by match to protein family HMM PF00005; match to protein family HMM TIGR03608; ABC transporter ATP-binding protein complement(1800327..1800968) Streptococcus pneumoniae G54 6478706 YP_002038570.1 CDS SPG_1889 NC_011072.1 1800970 1803000 R identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; bacteriocin-associated integral membrane protein complement(1800970..1803000) Streptococcus pneumoniae G54 6479904 YP_002038571.1 CDS SPG_1890 NC_011072.1 1803077 1803373 R identified by glimmer; putative; hypothetical protein complement(1803077..1803373) Streptococcus pneumoniae G54 6479769 YP_002038572.1 CDS SPG_1891 NC_011072.1 1803693 1804592 R transcriptional regulator PlcR complement(1803693..1804592) Streptococcus pneumoniae G54 6478860 YP_002038573.1 CDS SPG_1892 NC_011072.1 1804664 1805224 R identified by match to protein family HMM PF01751; match to protein family HMM TIGR00334; primase-like protein complement(1804664..1805224) Streptococcus pneumoniae G54 6479807 YP_002038574.1 CDS SPG_1893 NC_011072.1 1805224 1805997 R identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010; TatD family hydrolase complement(1805224..1805997) Streptococcus pneumoniae G54 6478665 YP_002038575.1 CDS SPG_1894 NC_011072.1 1806293 1806967 R identified by match to protein family HMM PF00746; match to protein family HMM TIGR01167; LPXTG-motif cell wall anchor domain complement(1806293..1806967) Streptococcus pneumoniae G54 6480793 YP_002038576.1 CDS rpmH NC_011072.1 1807230 1807364 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(1807230..1807364) Streptococcus pneumoniae G54 6480723 YP_002038577.1 CDS SPG_1896 NC_011072.1 1807509 1808723 R broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT complement(1807509..1808723) Streptococcus pneumoniae G54 6480764 YP_002038578.1 CDS SPG_1897 NC_011072.1 1808879 1809172 R hypothetical protein complement(1808879..1809172) Streptococcus pneumoniae G54 6479846 YP_002038579.1 CDS SPG_1898 NC_011072.1 1809335 1809787 D identified by match to protein family HMM PF00582; hypothetical protein 1809335..1809787 Streptococcus pneumoniae G54 6478799 YP_002038580.1 CDS SPG_1899 NC_011072.1 1809822 1811210 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; hypothetical protein complement(1809822..1811210) Streptococcus pneumoniae G54 6480012 YP_002038581.1 CDS SPG_1900 NC_011072.1 1811276 1812238 D identified by match to protein family HMM PF00710; L-asparaginase 1811276..1812238 Streptococcus pneumoniae G54 6480147 YP_002038582.1 CDS SPG_1901 NC_011072.1 1812444 1813454 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; match to protein family HMM TIGR01481; catabolite control protein CcpA complement(1812444..1813454) Streptococcus pneumoniae G54 6479165 YP_002038583.1 CDS SPG_1902 NC_011072.1 1813879 1814478 R identified by match to protein family HMM PF00072; match to protein family HMM PF00196; response regulator complement(1813879..1814478) Streptococcus pneumoniae G54 6480145 YP_002038584.1 CDS SPG_1903 NC_011072.1 1814480 1815577 R identified by match to protein family HMM PF02518; match to protein family HMM PF07730; histidine kinase complement(1814480..1815577) Streptococcus pneumoniae G54 6480376 YP_002038585.1 CDS SPG_1904 NC_011072.1 1815577 1816314 R identified by match to protein family HMM PF01061; hypothetical protein complement(1815577..1816314) Streptococcus pneumoniae G54 6478926 YP_002038586.1 CDS SPG_1905 NC_011072.1 1816316 1817200 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1816316..1817200) Streptococcus pneumoniae G54 6479796 YP_002038587.1 CDS SPG_1906 NC_011072.1 1817187 1817381 R hypothetical protein complement(1817187..1817381) Streptococcus pneumoniae G54 6479191 YP_002038588.1 CDS SPG_1907 NC_011072.1 1817378 1817584 R hypothetical protein complement(1817378..1817584) Streptococcus pneumoniae G54 6480220 YP_002038589.1 CDS SPG_1922 NC_011072.1 1824265 1824744 R transcriptional regulator ComX2 complement(1824265..1824744) Streptococcus pneumoniae G54 6480605 YP_002038590.1 CDS nusG NC_011072.1 1824866 1825402 R Modulates Rho-dependent transcription termination; transcription antitermination protein NusG complement(1824866..1825402) Streptococcus pneumoniae G54 6479633 YP_002038591.1 CDS secE NC_011072.1 1825457 1825633 R forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(1825457..1825633) Streptococcus pneumoniae G54 6479468 YP_002038592.1 CDS SPG_1925 NC_011072.1 1825848 1828043 R identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 2A complement(1825848..1828043) Streptococcus pneumoniae G54 6480194 YP_002038593.1 CDS SPG_1926 NC_011072.1 1828130 1829005 D identified by match to protein family HMM PF00849; RluD subfamily ribosomal large subunit pseudouridine synthase 1828130..1829005 Streptococcus pneumoniae G54 6478750 YP_002038594.1 CDS gap NC_011072.1 1829072 1830079 R identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; glyceraldehyde-3-phosphate dehydrogenase complement(1829072..1830079) Streptococcus pneumoniae G54 6480300 YP_002038595.1 CDS SPG_1928 NC_011072.1 1830256 1831089 R identified by match to protein family HMM PF02687; ABC transporter permease complement(1830256..1831089) Streptococcus pneumoniae G54 6480357 YP_002038596.1 CDS SPG_1929 NC_011072.1 1831761 1832138 R identified by match to protein family HMM PF01710; IS630-Spn1 transposase complement(1831761..1832138) Streptococcus pneumoniae G54 6479642 YP_002038597.1 CDS nadC NC_011072.1 1832269 1833141 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase complement(1832269..1833141) Streptococcus pneumoniae G54 6479034 YP_002038598.1 CDS SPG_1931 NC_011072.1 1833378 1834688 D identified by match to protein family HMM PF03600; match to protein family HMM PF07158; hypothetical protein 1833378..1834688 Streptococcus pneumoniae G54 6479416 YP_002038599.1 CDS SPG_1932 NC_011072.1 1835054 1835185 R hypothetical protein complement(1835054..1835185) Streptococcus pneumoniae G54 6479249 YP_002038600.1 CDS SPG_1933 NC_011072.1 1835707 1836435 R identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator complement(1835707..1836435) Streptococcus pneumoniae G54 6478951 YP_002038601.1 CDS SPG_1934 NC_011072.1 1836593 1838002 D identified by match to protein family HMM PF00232; glycosyl hydrolase family protein 1836593..1838002 Streptococcus pneumoniae G54 6479632 YP_002038602.1 CDS SPG_1935 NC_011072.1 1838020 1839315 D identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; PTS system transporter subunit IIC 1838020..1839315 Streptococcus pneumoniae G54 6478984 YP_002038603.1 CDS SPG_1936 NC_011072.1 1839320 1839628 D identified by match to protein family HMM PF02302; PTS system transporter subunit IIB 1839320..1839628 Streptococcus pneumoniae G54 6478693 YP_002038604.1 CDS SPG_1937 NC_011072.1 1839625 1839933 D identified by match to protein family HMM PF02255; PTS system transporter subunit IIA 1839625..1839933 Streptococcus pneumoniae G54 6480731 YP_002038605.1 CDS SPG_1938 NC_011072.1 1840722 1843373 R identified by match to protein family HMM PF00465; bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1840722..1843373) Streptococcus pneumoniae G54 6480314 YP_002038606.1 CDS SPG_1939 NC_011072.1 1843576 1843713 R identified by glimmer; putative; hypothetical protein complement(1843576..1843713) Streptococcus pneumoniae G54 6479192 YP_002038607.1 CDS SPG_1940 NC_011072.1 1843673 1844083 R identified by glimmer; putative; hypothetical protein complement(1843673..1844083) Streptococcus pneumoniae G54 6478851 YP_002038608.1 CDS SPG_1941 NC_011072.1 1844085 1844513 R identified by match to protein family HMM PF01451; phosphotyrosine protein phosphatase complement(1844085..1844513) Streptococcus pneumoniae G54 6480326 YP_002038609.1 CDS yajC NC_011072.1 1844559 1844858 R member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC complement(1844559..1844858) Streptococcus pneumoniae G54 6479207 YP_002038610.1 CDS tktA NC_011072.1 1844975 1846951 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(1844975..1846951) Streptococcus pneumoniae G54 6479890 YP_002038611.1 CDS SPG_1944 NC_011072.1 1847064 1848155 R putative L-ascorbate 6-phosphate lactonase complement(1847064..1848155) Streptococcus pneumoniae G54 6480613 YP_002038612.1 CDS SPG_1945 NC_011072.1 1848267 1849940 R identified by match to protein family HMM PF00874; match to protein family HMM PF08279; BglG family transcriptional regulator complement(1848267..1849940) Streptococcus pneumoniae G54 6480614 YP_002038613.1 CDS SPG_1946 NC_011072.1 1850117 1850575 R contains potential frameshift; identified by match to protein family HMM PF00596; L-ribulose-5-phosphate 4-epimerase complement(1850117..1850575) Streptococcus pneumoniae G54 6480102 YP_002038614.1 CDS SPG_1947 NC_011072.1 1850562 1850822 R contains potential frameshift; L-ribulose-5-phosphate 4-epimerase complement(1850562..1850822) Streptococcus pneumoniae G54 6479826 YP_002038615.1 CDS SPG_1948 NC_011072.1 1850824 1851687 R L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase complement(1850824..1851687) Streptococcus pneumoniae G54 6478815 YP_002038616.1 CDS ulaD NC_011072.1 1851691 1852356 R catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase complement(1851691..1852356) Streptococcus pneumoniae G54 6479341 YP_002038617.1 CDS SPG_1950 NC_011072.1 1852373 1852858 R identified by match to protein family HMM PF00359; PTS system transporter subunit IIA complement(1852373..1852858) Streptococcus pneumoniae G54 6479651 YP_002038618.1 CDS SPG_1951 NC_011072.1 1852935 1853216 R identified by match to protein family HMM PF02302; PTS system transporter subunit IIB complement(1852935..1853216) Streptococcus pneumoniae G54 6479581 YP_002038619.1 CDS SPG_1952 NC_011072.1 1853239 1854696 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(1853239..1854696) Streptococcus pneumoniae G54 6480482 YP_002038620.1 CDS SPG_1953 NC_011072.1 1854825 1855448 R hypothetical protein complement(1854825..1855448) Streptococcus pneumoniae G54 6478893 YP_002038621.1 CDS SPG_1954 NC_011072.1 1855499 1856485 R identified by glimmer; putative; hypothetical protein complement(1855499..1856485) Streptococcus pneumoniae G54 6479861 YP_002038622.1 CDS SPG_1955 NC_011072.1 1856504 1857328 R identified by match to protein family HMM PF02096; SpoIIIJ family protein complement(1856504..1857328) Streptococcus pneumoniae G54 6479092 YP_002038623.1 CDS rnpA NC_011072.1 1857303 1857674 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(1857303..1857674) Streptococcus pneumoniae G54 6480520 YP_002038624.1 CDS SPG_1957 NC_011072.1 1857691 1857822 R hypothetical protein complement(1857691..1857822) Streptococcus pneumoniae G54 6478735 YP_002038625.1 CDS ackA NC_011072.1 1857823 1859013 R AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase complement(1857823..1859013) Streptococcus pneumoniae G54 6480477 YP_002038626.1 CDS SPG_1959 NC_011072.1 1859064 1860017 R hypothetical protein complement(1859064..1860017) Streptococcus pneumoniae G54 6480739 YP_002038627.1 CDS SPG_1960 NC_011072.1 1860078 1860458 R identified by glimmer; putative; hypothetical protein complement(1860078..1860458) Streptococcus pneumoniae G54 6480564 YP_002038628.1 CDS SPG_1961 NC_011072.1 1860490 1860672 R hypothetical protein complement(1860490..1860672) Streptococcus pneumoniae G54 6479357 YP_002038629.1 CDS SPG_1962 NC_011072.1 1860809 1861222 R hypothetical protein complement(1860809..1861222) Streptococcus pneumoniae G54 6480046 YP_002038630.1 CDS SPG_1963 NC_011072.1 1861200 1861661 R hypothetical protein complement(1861200..1861661) Streptococcus pneumoniae G54 6479929 YP_002038631.1 CDS SPG_1964 NC_011072.1 1861624 1861926 R identified by glimmer; putative; hypothetical protein complement(1861624..1861926) Streptococcus pneumoniae G54 6480521 YP_002038632.1 CDS SPG_1965 NC_011072.1 1861889 1862293 R identified by match to protein family HMM TIGR02532; competence protein CglD complement(1861889..1862293) Streptococcus pneumoniae G54 6479315 YP_002038633.1 CDS SPG_1966 NC_011072.1 1862286 1862612 R identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532; competence protein CglC complement(1862286..1862612) Streptococcus pneumoniae G54 6480074 YP_002038634.1 CDS SPG_1967 NC_011072.1 1862614 1863630 R identified by match to protein family HMM PF00482; competence protein CglB complement(1862614..1863630) Streptococcus pneumoniae G54 6480813 YP_002038635.1 CDS SPG_1968 NC_011072.1 1863578 1864519 R identified by match to protein family HMM PF00437; competence protein CglA complement(1863578..1864519) Streptococcus pneumoniae G54 6480196 YP_002038636.1 CDS SPG_1969 NC_011072.1 1864595 1864960 R identified by match to protein family HMM PF06279; hypothetical protein complement(1864595..1864960) Streptococcus pneumoniae G54 6479842 YP_002038637.1 CDS SPG_1970 NC_011072.1 1865111 1866169 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; alcohol dehydrogenase complement(1865111..1866169) Streptococcus pneumoniae G54 6479813 YP_002038638.1 CDS nagA NC_011072.1 1866332 1867483 R identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221; N-acetylglucosamine-6-phosphate deacetylase complement(1866332..1867483) Streptococcus pneumoniae G54 6480298 YP_002038639.1 CDS SPG_1972 NC_011072.1 1867636 1869453 R identified by match to protein family HMM PF01757; putative acyltransferase complement(1867636..1869453) Streptococcus pneumoniae G54 6480251 YP_002038640.1 CDS tgt NC_011072.1 1869554 1870696 R Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase complement(1869554..1870696) Streptococcus pneumoniae G54 6479672 YP_002038641.1 CDS SPG_1974 NC_011072.1 1870826 1871683 D identified by match to protein family HMM PF06161; hypothetical protein 1870826..1871683 Streptococcus pneumoniae G54 6480714 YP_002038642.1 CDS SPG_1975 NC_011072.1 1871711 1872355 R catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase complement(1871711..1872355) Streptococcus pneumoniae G54 6480120 YP_002038643.1 CDS SPG_1976 NC_011072.1 1872462 1872821 R identified by match to protein family HMM PF06993; hypothetical protein complement(1872462..1872821) Streptococcus pneumoniae G54 6479875 YP_002038644.1 CDS SPG_1977 NC_011072.1 1872832 1873116 R MarR family transcriptional regulator complement(1872832..1873116) Streptococcus pneumoniae G54 6480582 YP_002038645.1 CDS SPG_1978 NC_011072.1 1873684 1874796 R identified by match to protein family HMM PF01476; LysM domain-containing protein complement(1873684..1874796) Streptococcus pneumoniae G54 6479864 YP_002038646.1 CDS SPG_1979 NC_011072.1 1874962 1875582 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; haloacid dehalogenase-like hydrolase complement(1874962..1875582) Streptococcus pneumoniae G54 6479610 YP_002038647.1 CDS SPG_1980 NC_011072.1 1875586 1876866 R identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; MATE efflux family protein complement(1875586..1876866) Streptococcus pneumoniae G54 6479210 YP_002038648.1 CDS thrC NC_011072.1 1876927 1878411 R catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase complement(1876927..1878411) Streptococcus pneumoniae G54 6478651 YP_002038649.1 CDS SPG_1982 NC_011072.1 1878487 1879764 R hypothetical protein complement(1878487..1879764) Streptococcus pneumoniae G54 6479845 YP_002038650.1 CDS SPG_1983 NC_011072.1 1880027 1880275 R identified by glimmer; putative; hypothetical protein complement(1880027..1880275) Streptococcus pneumoniae G54 6480337 YP_002038651.1 CDS SPG_1984 NC_011072.1 1880435 1880911 D identified by glimmer; putative; hypothetical protein 1880435..1880911 Streptococcus pneumoniae G54 6478641 YP_002038652.1 CDS SPG_1985 NC_011072.1 1881082 1881636 D identified by glimmer; putative; hypothetical protein 1881082..1881636 Streptococcus pneumoniae G54 6480021 YP_002038653.1 CDS SPG_1986 NC_011072.1 1882020 1882295 D hypothetical protein 1882020..1882295 Streptococcus pneumoniae G54 6479369 YP_002038654.1 CDS SPG_1987 NC_011072.1 1882409 1883542 D identified by match to protein family HMM PF00589; phage integrase family site-specific recombinase 1882409..1883542 Streptococcus pneumoniae G54 6480515 YP_002038655.1 CDS SPG_1988 NC_011072.1 1883583 1884020 D identified by glimmer; putative; hypothetical protein 1883583..1884020 Streptococcus pneumoniae G54 6478753 YP_002038656.1 CDS SPG_1989 NC_011072.1 1884236 1884472 D identified by glimmer; putative; hypothetical protein 1884236..1884472 Streptococcus pneumoniae G54 6480338 YP_002038657.1 CDS SPG_1990 NC_011072.1 1884465 1885196 D identified by match to protein family HMM PF00149; Ser/Thr protein phosphatase family protein 1884465..1885196 Streptococcus pneumoniae G54 6479515 YP_002038658.1 CDS SPG_2007 NC_011072.1 1891662 1892096 R identified by match to protein family HMM PF00383; cytidine/deoxycytidylate deaminase family protein complement(1891662..1892096) Streptococcus pneumoniae G54 6478781 YP_002038659.1 CDS gltX NC_011072.1 1892110 1893570 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(1892110..1893570) Streptococcus pneumoniae G54 6480517 YP_002038660.1 CDS pgi NC_011072.1 1893694 1895043 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(1893694..1895043) Streptococcus pneumoniae G54 6480581 YP_002038661.1 CDS SPG_2010 NC_011072.1 1895030 1895209 R hypothetical protein complement(1895030..1895209) Streptococcus pneumoniae G54 6479799 YP_002038662.1 CDS SPG_2011 NC_011072.1 1895213 1895902 R identified by match to protein family HMM PF00117; match to protein family HMM PF07722; glutamine amidotransferase complement(1895213..1895902) Streptococcus pneumoniae G54 6480408 YP_002038663.1 CDS SPG_2012 NC_011072.1 1896041 1897807 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein complement(1896041..1897807) Streptococcus pneumoniae G54 6478685 YP_002038664.1 CDS SPG_2013 NC_011072.1 1898059 1898268 D transposase 1898059..1898268 Streptococcus pneumoniae G54 6479870 YP_002038665.1 CDS SPG_2014 NC_011072.1 1898599 1900293 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding/permease complement(1898599..1900293) Streptococcus pneumoniae G54 6478991 YP_002038666.1 CDS SPG_2015 NC_011072.1 1900440 1902974 R This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS complement(1900440..1902974) Streptococcus pneumoniae G54 6479899 YP_002038667.1 CDS argR2 NC_011072.1 1903025 1903471 R identified by match to protein family HMM PF01316; match to protein family HMM PF02863; match to protein family HMM TIGR01529; arginine repressor complement(1903025..1903471) Streptococcus pneumoniae G54 6480156 YP_002038668.1 CDS argS NC_011072.1 1903607 1905298 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1903607..1905298 Streptococcus pneumoniae G54 6479671 YP_002038669.1 CDS SPG_2018 NC_011072.1 1905489 1905959 R identified by match to protein family HMM PF01609; transposase complement(1905489..1905959) Streptococcus pneumoniae G54 6479906 YP_002038670.1 CDS SPG_2019 NC_011072.1 1906032 1906517 D identified by match to protein family HMM PF06172; hypothetical protein 1906032..1906517 Streptococcus pneumoniae G54 6480118 YP_002038671.1 CDS pnpR NC_011072.1 1906601 1907308 D Novak, J Bacteriol. 1999 181(4):1126-33.; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator PnpR 1906601..1907308 Streptococcus pneumoniae G54 6480657 YP_002038672.1 CDS pnpS NC_011072.1 1907309 1908640 D identified by match to protein family HMM PF00512; match to protein family HMM PF02518; histidine kinase PnpS 1907309..1908640 Streptococcus pneumoniae G54 6480726 YP_002038673.1 CDS SPG_2022 NC_011072.1 1908807 1909682 D ABC transporter binding protein 1908807..1909682 Streptococcus pneumoniae G54 6479389 YP_002038674.1 CDS SPG_2023 NC_011072.1 1909800 1910663 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; ABC transporter permease 1909800..1910663 Streptococcus pneumoniae G54 6479006 YP_002038675.1 CDS SPG_2024 NC_011072.1 1910656 1911471 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; ABC transporter permease 1910656..1911471 Streptococcus pneumoniae G54 6479082 YP_002038676.1 CDS SPG_2025 NC_011072.1 1911473 1912225 D ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1911473..1912225 Streptococcus pneumoniae G54 6479957 YP_002038677.1 CDS SPG_2026 NC_011072.1 1912240 1912890 D identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein 1912240..1912890 Streptococcus pneumoniae G54 6480653 YP_002038678.1 CDS SPG_2027 NC_011072.1 1912958 1913383 D IS1380-Spn1 transposase 1912958..1913383 Streptococcus pneumoniae G54 6480773 YP_002038679.1 CDS SPG_2028 NC_011072.1 1913557 1913937 R identified by glimmer; putative; hypothetical protein complement(1913557..1913937) Streptococcus pneumoniae G54 6479593 YP_002038680.1 CDS gpsA NC_011072.1 1914149 1915165 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1914149..1915165 Streptococcus pneumoniae G54 6480636 YP_002038681.1 CDS galU NC_011072.1 1915187 1916086 D identified by match to protein family HMM PF00483; match to protein family HMM TIGR01099; UTP-glucose-1-phosphate uridylyltransferase 1915187..1916086 Streptococcus pneumoniae G54 6479021 YP_002038682.1 CDS SPG_2031 NC_011072.1 1916153 1916830 R identified by match to protein family HMM PF01694; S54 (rhomboid) family peptidase complement(1916153..1916830) Streptococcus pneumoniae G54 6479015 YP_002038683.1 CDS SPG_2032 NC_011072.1 1916814 1917353 R identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; 5-formyltetrahydrofolate cyclo-ligase family protein complement(1916814..1917353) Streptococcus pneumoniae G54 6479836 YP_002038684.1 CDS SPG_2033 NC_011072.1 1917365 1918495 R identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01891; M20/M25/M40 family peptidase complement(1917365..1918495) Streptococcus pneumoniae G54 6480597 YP_002038685.1 CDS dapD NC_011072.1 1918563 1919261 R identified by match to protein family HMM PF00132; match to protein family HMM PF08503; 2,3,4, 5-tetrahydropyridine-2-carboxylate-aminotransferase complement(1918563..1919261) Streptococcus pneumoniae G54 6479784 YP_002038686.1 CDS SPG_2035 NC_011072.1 1919492 1920403 R identified by match to protein family HMM PF00892; hypothetical protein complement(1919492..1920403) Streptococcus pneumoniae G54 6480736 YP_002038687.1 CDS SPG_2036 NC_011072.1 1920468 1922933 R identified by match to protein family HMM PF00905; match to protein family HMM PF00912; penicillin-binding protein 1B complement(1920468..1922933) Streptococcus pneumoniae G54 6479649 YP_002038688.1 CDS tyrS NC_011072.1 1923075 1924331 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1923075..1924331 Streptococcus pneumoniae G54 6478699 YP_002038689.1 CDS SPG_2038 NC_011072.1 1924409 1926472 R identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01525; E1-E2 family cation-transporting ATPase complement(1924409..1926472) Streptococcus pneumoniae G54 6480327 YP_002038690.1 CDS SPG_2039 NC_011072.1 1926474 1926752 R hypothetical protein complement(1926474..1926752) Streptococcus pneumoniae G54 6478976 YP_002038691.1 CDS SPG_2040 NC_011072.1 1926904 1927752 D identified by match to protein family HMM PF08241; methyltransferase 1926904..1927752 Streptococcus pneumoniae G54 6480211 YP_002038692.1 CDS SPG_2041 NC_011072.1 1928358 1928564 R hypothetical protein complement(1928358..1928564) Streptococcus pneumoniae G54 6479478 YP_002038693.1 CDS SPG_2042 NC_011072.1 1928686 1929213 D hypothetical protein 1928686..1929213 Streptococcus pneumoniae G54 6478694 YP_002038694.1 CDS glgP NC_011072.1 1930258 1932516 R Spatafora,G.A. 1992 Inf.& Imm.; identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093; alpha-glucan phosphorylase complement(1930258..1932516) Streptococcus pneumoniae G54 6478784 YP_002038695.1 CDS malQ NC_011072.1 1932542 1934059 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(1932542..1934059) Streptococcus pneumoniae G54 6479013 YP_002038696.1 CDS malX NC_011072.1 1934609 1935880 D identified by match to protein family HMM PF01547; maltose/maltodextrin ABC transporter maltose/maltodextrin-binding protein 1934609..1935880 Streptococcus pneumoniae G54 6479994 YP_002038697.1 CDS malC NC_011072.1 1935991 1937283 D identified by match to protein family HMM PF00528; match to protein family HMM PF05154; maltodextrin transport system permease MalC 1935991..1937283 Streptococcus pneumoniae G54 6479259 YP_002038698.1 CDS malD NC_011072.1 1937285 1938127 D identified by match to protein family HMM PF00528; maltodextrin ABC transporter permease MalD 1937285..1938127 Streptococcus pneumoniae G54 6480161 YP_002038699.1 CDS malA NC_011072.1 1938380 1939180 D maltodextrose utilization protein MalA 1938380..1939180 Streptococcus pneumoniae G54 6479989 YP_002038700.1 CDS malR NC_011072.1 1939190 1940176 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; maltose operon transcriptional 1939190..1940176 Streptococcus pneumoniae G54 6479972 YP_002038701.1 CDS SPG_2050 NC_011072.1 1940647 1941588 R identified by match to protein family HMM PF02588; hypothetical protein complement(1940647..1941588) Streptococcus pneumoniae G54 6480385 YP_002038702.1 CDS aspS NC_011072.1 1941566 1943329 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(1941566..1943329) Streptococcus pneumoniae G54 6478995 YP_002038703.1 CDS SPG_2052 NC_011072.1 1943681 1943911 R hypothetical protein complement(1943681..1943911) Streptococcus pneumoniae G54 6479591 YP_002038704.1 CDS SPG_2053 NC_011072.1 1943929 1944570 R identified by match to protein family HMM PF02517; CAAX amino terminal protease family complement(1943929..1944570) Streptococcus pneumoniae G54 6479625 YP_002038705.1 CDS SPG_2054 NC_011072.1 1944582 1945316 R hypothetical protein complement(1944582..1945316) Streptococcus pneumoniae G54 6480258 YP_002038706.1 CDS SPG_2055 NC_011072.1 1945319 1945516 R hypothetical protein complement(1945319..1945516) Streptococcus pneumoniae G54 6478704 YP_002038707.1 CDS SPG_2056 NC_011072.1 1945516 1945722 R identified by match to protein family HMM PF01381; hypothetical protein complement(1945516..1945722) Streptococcus pneumoniae G54 6479795 YP_002038708.1 CDS SPG_2057 NC_011072.1 1945732 1946046 R hypothetical protein complement(1945732..1946046) Streptococcus pneumoniae G54 6478664 YP_002038709.1 CDS hisS NC_011072.1 1946388 1947677 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(1946388..1947677) Streptococcus pneumoniae G54 6479184 YP_002038710.1 CDS SPG_2059 NC_011072.1 1947755 1949002 R identified by match to protein family HMM PF07690; major facilitator family transporter complement(1947755..1949002) Streptococcus pneumoniae G54 6480335 YP_002038711.1 CDS SPG_2060 NC_011072.1 1949193 1950044 R identified by match to protein family HMM TIGR01716; Rgg/GadR/MutR family transcriptional activator complement(1949193..1950044) Streptococcus pneumoniae G54 6479225 YP_002038712.1 CDS SPG_2061 NC_011072.1 1950019 1950153 R hypothetical protein complement(1950019..1950153) Streptococcus pneumoniae G54 6480701 YP_002038713.1 CDS SPG_2062 NC_011072.1 1950168 1950509 D identified by match to protein family HMM PF01883; hypothetical protein 1950168..1950509 Streptococcus pneumoniae G54 6478941 YP_002038714.1 CDS SPG_2063 NC_011072.1 1950763 1952466 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(1950763..1952466) Streptococcus pneumoniae G54 6478791 YP_002038715.1 CDS SPG_2064 NC_011072.1 1952699 1953631 R identified by match to protein family HMM PF02779; match to protein family HMM PF02780; transketolase, C-terminal subunit complement(1952699..1953631) Streptococcus pneumoniae G54 6480474 YP_002038716.1 CDS SPG_2065 NC_011072.1 1953628 1954485 R identified by match to protein family HMM PF00456; transketolase N-terminal section complement(1953628..1954485) Streptococcus pneumoniae G54 6479817 YP_002038717.1 CDS ulaA NC_011072.1 1954489 1955835 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(1954489..1955835) Streptococcus pneumoniae G54 6479912 YP_002038718.1 CDS SPG_2067 NC_011072.1 1955848 1956132 R identified by match to protein family HMM PF02302; PTS system transporter subunit IIB complement(1955848..1956132) Streptococcus pneumoniae G54 6479118 YP_002038719.1 CDS SPG_2068 NC_011072.1 1956136 1956489 R contains potential frameshift; identified by match to protein family HMM PF00359; PTS system transporter subunit IIA complement(1956136..1956489) Streptococcus pneumoniae G54 6478974 YP_002038720.1 CDS SPG_2069 NC_011072.1 1956542 1958167 R contains potential frameshift; identified by match to protein family HMM PF00874; BglG family transcriptional regulator complement(1956542..1958167) Streptococcus pneumoniae G54 6479956 YP_002038721.1 CDS SPG_2070 NC_011072.1 1958358 1958810 D contains potential frameshift; hypothetical protein 1958358..1958810 Streptococcus pneumoniae G54 6480064 YP_002038722.1 CDS SPG_2071 NC_011072.1 1958776 1959366 D contains potential frameshift; hypothetical protein 1958776..1959366 Streptococcus pneumoniae G54 6479575 YP_002038723.1 CDS rpmF NC_011072.1 1959722 1959904 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1959722..1959904 Streptococcus pneumoniae G54 6480399 YP_002038724.1 CDS rpmG NC_011072.1 1959920 1960069 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1959920..1960069 Streptococcus pneumoniae G54 6480273 YP_002038725.1 CDS pcpA NC_011072.1 1960549 1962354 R identified by match to protein family HMM PF01473; choline binding protein PcpA complement(1960549..1962354) Streptococcus pneumoniae G54 6479237 YP_002038726.1 CDS SPG_2076 NC_011072.1 1962689 1963054 D identified by match to protein family HMM PF04326; IS1381 transposase 1962689..1963054 Streptococcus pneumoniae G54 6479276 YP_002038727.1 CDS SPG_2077 NC_011072.1 1963199 1963339 D IS1381 transposase 1963199..1963339 Streptococcus pneumoniae G54 6480642 YP_002038728.1 CDS SPG_2078 NC_011072.1 1963369 1963668 D transposase 1963369..1963668 Streptococcus pneumoniae G54 6478713 YP_002038729.1 CDS SPG_2079 NC_011072.1 1963831 1963995 R hypothetical protein complement(1963831..1963995) Streptococcus pneumoniae G54 6479327 YP_002038730.1 CDS SPG_2080 NC_011072.1 1964061 1964192 R identified by glimmer; putative; hypothetical protein complement(1964061..1964192) Streptococcus pneumoniae G54 6480246 YP_002038731.1 CDS SPG_2081 NC_011072.1 1964459 1966339 R identified by match to protein family HMM PF00728; glycosyl hydrolase family protein complement(1964459..1966339) Streptococcus pneumoniae G54 6479946 YP_002038732.1 CDS SPG_2082 NC_011072.1 1966333 1967202 R identified by match to protein family HMM PF00480; ROK family protein complement(1966333..1967202) Streptococcus pneumoniae G54 6479867 YP_002038733.1 CDS SPG_2083 NC_011072.1 1967284 1969929 R identified by match to protein family HMM PF01074; match to protein family HMM PF07748; hypothetical protein complement(1967284..1969929) Streptococcus pneumoniae G54 6478898 YP_002038734.1 CDS SPG_2084 NC_011072.1 1970020 1971300 R identified by match to protein family HMM PF06824; hypothetical protein complement(1970020..1971300) Streptococcus pneumoniae G54 6480530 YP_002038735.1 CDS SPG_2085 NC_011072.1 1971471 1973555 D identified by match to protein family HMM PF07971; match to protein family HMM TIGR01180; alpha-1,2-mannosidase 1971471..1973555 Streptococcus pneumoniae G54 6480737 YP_002038736.1 CDS SPG_2086 NC_011072.1 1973595 1975274 R identified by glimmer; putative; hypothetical protein complement(1973595..1975274) Streptococcus pneumoniae G54 6479902 YP_002038737.1 CDS SPG_2087 NC_011072.1 1975318 1975431 R identified by glimmer; putative; hypothetical protein complement(1975318..1975431) Streptococcus pneumoniae G54 6479962 YP_002038738.1 CDS arcA NC_011072.1 1976028 1977257 D catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 1976028..1977257 Streptococcus pneumoniae G54 6480571 YP_002038739.1 CDS argF NC_011072.1 1977315 1978331 D catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 1977315..1978331 Streptococcus pneumoniae G54 6479430 YP_002038740.1 CDS SPG_2090 NC_011072.1 1978496 1979443 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1978496..1979443 Streptococcus pneumoniae G54 6480076 YP_002038741.1 CDS SPG_2091 NC_011072.1 1979654 1981165 D identified by match to protein family HMM PF03606; hypothetical protein 1979654..1981165 Streptococcus pneumoniae G54 6480320 YP_002038742.1 CDS SPG_2092 NC_011072.1 1981187 1982518 D identified by match to protein family HMM PF01546; match to protein family HMM TIGR01887; hypothetical protein 1981187..1982518 Streptococcus pneumoniae G54 6479885 YP_002038743.1 CDS SPG_2093 NC_011072.1 1982905 1983195 R hypothetical protein complement(1982905..1983195) Streptococcus pneumoniae G54 6478861 YP_002038744.1 CDS SPG_2094 NC_011072.1 1983183 1983434 R identified by glimmer; putative; hypothetical protein complement(1983183..1983434) Streptococcus pneumoniae G54 6480101 YP_002038745.1 CDS SPG_2095 NC_011072.1 1983788 1984687 R identified by match to protein family HMM PF01145; hypothetical protein complement(1983788..1984687) Streptococcus pneumoniae G54 6480550 YP_002038746.1 CDS SPG_2096 NC_011072.1 1984817 1985968 R identified by match to protein family HMM PF00465; alcohol dehydrogenase complement(1984817..1985968) Streptococcus pneumoniae G54 6479102 YP_002038747.1 CDS SPG_2097 NC_011072.1 1986114 1986395 R contains potential frameshift; L-fucose isomerase complement(1986114..1986395) Streptococcus pneumoniae G54 6480366 YP_002038748.1 CDS SPG_2098 NC_011072.1 1986365 1987879 R contains potential frameshift; identified by match to protein family HMM PF02952; match to protein family HMM PF07881; match to protein family HMM PF07882; L-fucose isomerase complement(1986365..1987879) Streptococcus pneumoniae G54 6479857 YP_002038749.1 CDS SPG_2099 NC_011072.1 1987892 1988620 R contains potential frameshift; identified by match to protein family HMM PF00596; L-fuculose-phosphate aldolase complement(1987892..1988620) Streptococcus pneumoniae G54 6480611 YP_002038750.1 CDS SPG_2100 NC_011072.1 1988635 1989783 R contains potential frameshift; blood group cleaving endo-beta-galactosidase complement(1988635..1989783) Streptococcus pneumoniae G54 6478865 YP_002038751.1 CDS SPG_2101 NC_011072.1 1989921 1991651 R contains potential frameshift; identified by match to protein family HMM PF08305; blood group cleaving endo-beta-galactosidase complement(1989921..1991651) Streptococcus pneumoniae G54 6480036 YP_002038752.1 CDS SPG_2102 NC_011072.1 1991662 1993878 R identified by match to protein family HMM PF02065; glycosyl hydrolase family protein complement(1991662..1993878) Streptococcus pneumoniae G54 6479652 YP_002038753.1 CDS SPG_2103 NC_011072.1 1993900 1995771 R identified by glimmer; putative; hypothetical protein complement(1993900..1995771) Streptococcus pneumoniae G54 6480048 YP_002038754.1 CDS SPG_2104 NC_011072.1 1995777 1997096 R identified by match to protein family HMM PF01120; alpha-L-fucosidase complement(1995777..1997096) Streptococcus pneumoniae G54 6479487 YP_002038755.1 CDS SPG_2105 NC_011072.1 1997093 1997932 R identified by match to protein family HMM PF00528; ABC transporter ATP-binding/permease complement(1997093..1997932) Streptococcus pneumoniae G54 6478797 YP_002038756.1 CDS SPG_2106 NC_011072.1 1997935 1998864 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1997935..1998864) Streptococcus pneumoniae G54 6480807 YP_002038757.1 CDS SPG_2107 NC_011072.1 1998951 2000243 R identified by match to protein family HMM PF01547; ABC transporter binding protein complement(1998951..2000243) Streptococcus pneumoniae G54 6479447 YP_002038758.1 CDS SPG_2108 NC_011072.1 2000272 2001675 R identified by match to protein family HMM PF00370; L-fuculose kinase FucK complement(2000272..2001675) Streptococcus pneumoniae G54 6480040 YP_002038759.1 CDS SPG_2109 NC_011072.1 2001851 2002624 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; DeoR family fucose operon regulator 2001851..2002624 Streptococcus pneumoniae G54 6479768 YP_002038760.1 CDS SPG_2110 NC_011072.1 2003410 2004915 R identified by match to protein family HMM PF01297; match to protein family HMM PF09223; zinc ABC transporter zinc-binding lipoprotein complement(2003410..2004915) Streptococcus pneumoniae G54 6479726 YP_002038761.1 CDS SPG_2111 NC_011072.1 2004925 2005731 R identified by match to protein family HMM PF00950; zinc ABC transporter permease complement(2004925..2005731) Streptococcus pneumoniae G54 6479202 YP_002038762.1 CDS SPG_2112 NC_011072.1 2005724 2006428 R identified by match to protein family HMM PF00005; zinc ABC transporter ATP-binding protein complement(2005724..2006428) Streptococcus pneumoniae G54 6480735 YP_002038763.1 CDS SPG_2113 NC_011072.1 2006428 2006868 R identified by match to protein family HMM PF01022; match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF01978; match to protein family HMM PF08279; MarR family transcriptional regulator complement(2006428..2006868) Streptococcus pneumoniae G54 6479081 YP_002038764.1 CDS SPG_2114 NC_011072.1 2006853 2006990 D identified by glimmer; putative; hypothetical protein 2006853..2006990 Streptococcus pneumoniae G54 6479456 YP_002038765.1 CDS dltD NC_011072.1 2007023 2008291 R identified by match to protein family HMM PF04914; match to protein family HMM PF04915; match to protein family HMM PF04918; undecaprenol-phosphate-poly(glycerophosphate subunit) D-alanine complement(2007023..2008291) Streptococcus pneumoniae G54 6480139 YP_002038766.1 CDS dltC NC_011072.1 2008284 2008523 R D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 complement(2008284..2008523) Streptococcus pneumoniae G54 6480665 YP_002038767.1 CDS dltB NC_011072.1 2008537 2009781 R identified by match to protein family HMM PF03062; D-alanine transfer from Dcp to undecaprenol-phosphate complement(2008537..2009781) Streptococcus pneumoniae G54 6479908 YP_002038768.1 CDS dltA NC_011072.1 2009778 2011328 R transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 complement(2009778..2011328) Streptococcus pneumoniae G54 6478979 YP_002038769.1 CDS SPG_2119 NC_011072.1 2011349 2011480 R hypothetical protein complement(2011349..2011480) Streptococcus pneumoniae G54 6479150 YP_002038770.1 CDS SPG_2120 NC_011072.1 2011794 2012972 R hypothetical protein complement(2011794..2012972) Streptococcus pneumoniae G54 6479604 YP_002038771.1 CDS SPG_2121 NC_011072.1 2013429 2014706 R identified by match to protein family HMM PF00078; match to protein family HMM PF08388; putative group II intron protein complement(2013429..2014706) Streptococcus pneumoniae G54 6480291 YP_002038772.1 CDS SPG_2122 NC_011072.1 2015947 2016138 D hypothetical protein 2015947..2016138 Streptococcus pneumoniae G54 6479658 YP_002038773.1 CDS SPG_2123 NC_011072.1 2016540 2016686 R hypothetical protein complement(2016540..2016686) Streptococcus pneumoniae G54 6479395 YP_002038774.1 CDS SPG_2124 NC_011072.1 2016836 2016961 D identified by glimmer; putative; hypothetical protein 2016836..2016961 Streptococcus pneumoniae G54 6479578 YP_002038775.1 CDS SPG_2125 NC_011072.1 2017040 2017744 R identified by match to protein family HMM PF00230; match to protein family HMM TIGR00861; glycerol uptake facilitator protein complement(2017040..2017744) Streptococcus pneumoniae G54 6479697 YP_002038776.1 CDS SPG_2126 NC_011072.1 2017812 2019638 R identified by match to protein family HMM PF01266; alpha-glycerophosphate oxidase complement(2017812..2019638) Streptococcus pneumoniae G54 6479982 YP_002038777.1 CDS glpK NC_011072.1 2019680 2021188 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(2019680..2021188) Streptococcus pneumoniae G54 6480264 YP_002038778.1 CDS SPG_2128 NC_011072.1 2021347 2022756 R identified by match to protein family HMM PF05043; hypothetical protein complement(2021347..2022756) Streptococcus pneumoniae G54 6480780 YP_002038779.1 CDS hslO NC_011072.1 2022939 2023811 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 2022939..2023811 Streptococcus pneumoniae G54 6479963 YP_002038780.1 CDS SPG_2130 NC_011072.1 2023798 2024778 D identified by match to protein family HMM PF00724; match to protein family HMM PF01180; match to protein family HMM PF01207; match to protein family HMM TIGR00737; dihydrouridine synthase 2023798..2024778 Streptococcus pneumoniae G54 6479958 YP_002038781.1 CDS SPG_2131 NC_011072.1 2024874 2025389 D identified by match to protein family HMM PF01527; IS3-Spn1 transposase 2024874..2025389 Streptococcus pneumoniae G54 6479538 YP_002038782.1 CDS SPG_2132 NC_011072.1 2025389 2026222 D identified by match to protein family HMM PF00665; IS3-Spn1 transposase 2025389..2026222 Streptococcus pneumoniae G54 6480106 YP_002038783.1 CDS SPG_2133 NC_011072.1 2026356 2026874 D IS1167 transposase 2026356..2026874 Streptococcus pneumoniae G54 6479973 YP_002038784.1 CDS SPG_2134 NC_011072.1 2026871 2027632 D identified by match to protein family HMM PF01610; IS1167 transposase 2026871..2027632 Streptococcus pneumoniae G54 6478917 YP_002038785.1 CDS pspC NC_011072.1 2027843 2030152 R identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF05062; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; surface protein PspC complement(2027843..2030152) Streptococcus pneumoniae G54 6480115 YP_002038786.1 CDS SPG_2136 NC_011072.1 2030230 2030757 R identified by match to protein family HMM PF04140; Isoprenylcysteine carboxyl methyltransferase (ICMT) family complement(2030230..2030757) Streptococcus pneumoniae G54 6480783 YP_002038787.1 CDS SPG_2137 NC_011072.1 2030852 2032192 R identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; histidine kinase complement(2030852..2032192) Streptococcus pneumoniae G54 6479362 YP_002038788.1 CDS SPG_2138 NC_011072.1 2032189 2032842 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator complement(2032189..2032842) Streptococcus pneumoniae G54 6480160 YP_002038789.1 CDS SPG_2139 NC_011072.1 2033131 2033265 R identified by glimmer; putative; hypothetical protein complement(2033131..2033265) Streptococcus pneumoniae G54 6480059 YP_002038790.1 CDS SPG_2140 NC_011072.1 2033282 2033413 D identified by glimmer; putative; hypothetical protein 2033282..2033413 Streptococcus pneumoniae G54 6479464 YP_002038791.1 CDS SPG_2141 NC_011072.1 2033484 2035916 R identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; ATP-dependent Clp protease ATP-binding subunit complement(2033484..2035916) Streptococcus pneumoniae G54 6479119 YP_002038792.1 CDS ctsR NC_011072.1 2035918 2036376 R identified by match to protein family HMM PF05848; transcriptional regulator CtsR complement(2035918..2036376) Streptococcus pneumoniae G54 6479033 YP_002038793.1 CDS SPG_2143 NC_011072.1 2036495 2037223 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(2036495..2037223) Streptococcus pneumoniae G54 6480575 YP_002038794.1 CDS SPG_2144 NC_011072.1 2037223 2038230 R identified by match to protein family HMM PF09084; ABC transporter substrate binding protein complement(2037223..2038230) Streptococcus pneumoniae G54 6479828 YP_002038795.1 CDS SPG_2145 NC_011072.1 2038268 2039017 R identified by match to protein family HMM PF00528; ABC transporter permease complement(2038268..2039017) Streptococcus pneumoniae G54 6480489 YP_002038796.1 CDS SPG_2146 NC_011072.1 2038989 2039279 R hypothetical protein complement(2038989..2039279) Streptococcus pneumoniae G54 6479496 YP_002038797.1 CDS cbpD NC_011072.1 2039534 2040832 R identified by match to protein family HMM PF01473; match to protein family HMM PF05257; match to protein family HMM PF08460; choline binding protein D complement(2039534..2040832) Streptococcus pneumoniae G54 6478692 YP_002038798.1 CDS SPG_2148 NC_011072.1 2040970 2041236 R identified by match to protein family HMM PF06257; hypothetical protein complement(2040970..2041236) Streptococcus pneumoniae G54 6479219 YP_002038799.1 CDS dnaB NC_011072.1 2041238 2042590 R unwinds double stranded DNA; replicative DNA helicase complement(2041238..2042590) Streptococcus pneumoniae G54 6478927 YP_002038800.1 CDS rplI NC_011072.1 2042633 2043085 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(2042633..2043085) Streptococcus pneumoniae G54 6480495 YP_002038801.1 CDS SPG_2151 NC_011072.1 2043082 2045055 R identified by match to protein family HMM PF01368; match to protein family HMM PF02272; DHH 1 family protein complement(2043082..2045055) Streptococcus pneumoniae G54 6479366 YP_002038802.1 CDS yfiA NC_011072.1 2045191 2045739 R identified by match to protein family HMM PF02482; match to protein family HMM TIGR00741; ribosomal subunit interface protein complement(2045191..2045739) Streptococcus pneumoniae G54 6479042 YP_002038803.1 CDS SPG_2153 NC_011072.1 2045819 2046481 R competence protein ComF complement(2045819..2046481) Streptococcus pneumoniae G54 6479476 YP_002038804.1 CDS SPG_2154 NC_011072.1 2046478 2047776 R identified by match to protein family HMM PF00271; match to protein family HMM PF04851; helicase complement(2046478..2047776) Streptococcus pneumoniae G54 6479786 YP_002038805.1 CDS SPG_2155 NC_011072.1 2047832 2048467 D identified by match to protein family HMM PF01205; match to protein family HMM PF09186; match to protein family HMM TIGR00257; hypothetical protein 2047832..2048467 Streptococcus pneumoniae G54 6479205 YP_002038806.1 CDS SPG_2156 NC_011072.1 2048752 2049672 D identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; cysteine synthase 2048752..2049672 Streptococcus pneumoniae G54 6480541 YP_002038807.1 CDS SPG_2157 NC_011072.1 2049869 2050267 R identified by match to protein family HMM PF03050; IS66-Spn1 transposase complement(2049869..2050267) Streptococcus pneumoniae G54 6480413 YP_002038808.1 CDS SPG_2158 NC_011072.1 2050300 2050545 D IS630-SpnII transposase 2050300..2050545 Streptococcus pneumoniae G54 6479901 YP_002038809.1 CDS SPG_2159 NC_011072.1 2050686 2051009 R identified by match to protein family HMM PF05717; IS66-Spn1 transposase complement(2050686..2051009) Streptococcus pneumoniae G54 6479134 YP_002038810.1 CDS tsf NC_011072.1 2051255 2052295 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(2051255..2052295) Streptococcus pneumoniae G54 6480198 YP_002038811.1 CDS rpsB NC_011072.1 2052374 2053153 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(2052374..2053153) Streptococcus pneumoniae G54 6480649 YP_002038812.1 CDS SPG_2162 NC_011072.1 2053377 2054555 R identified by match to protein family HMM PF05257; CHAP domain-containing protein complement(2053377..2054555) Streptococcus pneumoniae G54 6478912 YP_002038813.1 CDS SPG_2163 NC_011072.1 2054649 2055143 R identified by match to protein family HMM PF04093; match to protein family HMM TIGR03426; cell-shape determining protein MreD complement(2054649..2055143) Streptococcus pneumoniae G54 6479577 YP_002038814.1 CDS SPG_2164 NC_011072.1 2055143 2055961 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(2055143..2055961) Streptococcus pneumoniae G54 6478719 YP_002038815.1 CDS SPG_2165 NC_011072.1 2056020 2056814 R identified by match to protein family HMM PF02361; ABC transporter permease complement(2056020..2056814) Streptococcus pneumoniae G54 6480436 YP_002038816.1 CDS cbiO NC_011072.1 2056807 2057646 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2056807..2057646) Streptococcus pneumoniae G54 6479326 YP_002038817.1 CDS cbiO NC_011072.1 2057631 2058458 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2057631..2058458) Streptococcus pneumoniae G54 6479322 YP_002038818.1 CDS pgsA NC_011072.1 2058455 2059000 R identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase complement(2058455..2059000) Streptococcus pneumoniae G54 6479710 YP_002038819.1 CDS SPG_2169 NC_011072.1 2059011 2059832 R hypothetical protein complement(2059011..2059832) Streptococcus pneumoniae G54 6480204 YP_002038820.1 CDS SPG_2170 NC_011072.1 2059874 2061157 R identified by match to protein family HMM PF00675; match to protein family HMM PF05193; M16 family peptidase complement(2059874..2061157) Streptococcus pneumoniae G54 6479645 YP_002038821.1 CDS SPG_2171 NC_011072.1 2061154 2062404 R identified by match to protein family HMM PF05193; M16 family peptidase complement(2061154..2062404) Streptococcus pneumoniae G54 6478892 YP_002038822.1 CDS SPG_2172 NC_011072.1 2062563 2062931 D identified by glimmer; putative; hypothetical protein 2062563..2062931 Streptococcus pneumoniae G54 6480596 YP_002038823.1 CDS recF NC_011072.1 2062934 2064031 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2062934..2064031 Streptococcus pneumoniae G54 6479600 YP_002038824.1 CDS SPG_2174 NC_011072.1 2064082 2065560 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2064082..2065560) Streptococcus pneumoniae G54 6480034 YP_002038825.1 CDS trpS NC_011072.1 2065712 2066737 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II complement(2065712..2066737) Streptococcus pneumoniae G54 6479968 YP_002038826.1 CDS SPG_2176 NC_011072.1 2066943 2068565 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 2066943..2068565 Streptococcus pneumoniae G54 6479643 YP_002038827.1 CDS SPG_2177 NC_011072.1 2068627 2071179 D ABC transporter permease 2068627..2071179 Streptococcus pneumoniae G54 6480441 YP_002038828.1 CDS SPG_2178 NC_011072.1 2071622 2071960 R hypothetical protein complement(2071622..2071960) Streptococcus pneumoniae G54 6480789 YP_002038829.1 CDS SPG_2179 NC_011072.1 2072045 2072812 R identified by glimmer; putative; hypothetical protein complement(2072045..2072812) Streptococcus pneumoniae G54 6479897 YP_002038830.1 CDS SPG_2180 NC_011072.1 2072991 2073533 D identified by match to protein family HMM PF00440; hypothetical protein 2072991..2073533 Streptococcus pneumoniae G54 6479035 YP_002038831.1 CDS comE NC_011072.1 2073776 2074528 R identified by match to protein family HMM PF00072; match to protein family HMM PF04397; ComE response regulator TCS12 complement(2073776..2074528) Streptococcus pneumoniae G54 6480616 YP_002038832.1 CDS comD NC_011072.1 2074525 2075850 R identified by match to protein family HMM PF02518; ComD histidine kinase TCS12 complement(2074525..2075850) Streptococcus pneumoniae G54 6478696 YP_002038833.1 CDS comC NC_011072.1 2075871 2075996 R identified by match to protein family HMM PF03047; competence-stimulating peptide type 1 complement(2075871..2075996) Streptococcus pneumoniae G54 6478779 YP_002038834.1 CDS SPG_2187 NC_011072.1 2076278 2076757 R SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(2076278..2076757) Streptococcus pneumoniae G54 6479584 YP_002038835.1 CDS SPG_2188 NC_011072.1 2076940 2078121 D identified by match to protein family HMM PF00089; serine protease 2076940..2078121 Streptococcus pneumoniae G54 6480135 YP_002038836.1 CDS SPG_2189 NC_011072.1 2078179 2078937 D identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; ParB-like partition protein 2078179..2078937 Streptococcus pneumoniae G54 6478723 SPG_0015 tRNA SPG_0015 NC_011072.1 15023 15094 D tRNA-Glu 15023..15094 Streptococcus pneumoniae G54 6480084 SPG_0017 tRNA SPG_0017 NC_011072.1 16944 17016 D tRNA-Ala 16944..17016 Streptococcus pneumoniae G54 6480686 SPG_0020 tRNA SPG_0020 NC_011072.1 20240 20313 D tRNA-Asn 20240..20313 Streptococcus pneumoniae G54 6480680 SPG_0782 tRNA SPG_0782 NC_011072.1 757941 758021 D tRNA-Tyr 757941..758021 Streptococcus pneumoniae G54 6478681 SPG_0783 tRNA SPG_0783 NC_011072.1 758031 758102 D tRNA-Gln 758031..758102 Streptococcus pneumoniae G54 6480353 SPG_0798 tRNA SPG_0798 NC_011072.1 772621 772708 R tRNA-Ser complement(772621..772708) Streptococcus pneumoniae G54 6480498 SPG_0939 tRNA SPG_0939 NC_011072.1 904605 904677 D tRNA-Thr 904605..904677 Streptococcus pneumoniae G54 6478946 SPG_1139 tRNA SPG_1139 NC_011072.1 1119646 1119717 R tRNA-Arg complement(1119646..1119717) Streptococcus pneumoniae G54 6480641 SPG_1186 tRNA SPG_1186 NC_011072.1 1161366 1161437 R tRNA-Arg complement(1161366..1161437) Streptococcus pneumoniae G54 6478661 SPG_1507 tRNA SPG_1507 NC_011072.1 1452164 1452249 R tRNA-Leu complement(1452164..1452249) Streptococcus pneumoniae G54 6479020 SPG_1680 tRNA SPG_1680 NC_011072.1 1620156 1620228 D tRNA-Lys 1620156..1620228 Streptococcus pneumoniae G54 6479881 SPG_1788 tRNA SPG_1788 NC_011072.1 1725327 1725414 R tRNA-Ser complement(1725327..1725414) Streptococcus pneumoniae G54 6478961 SPG_1789 tRNA SPG_1789 NC_011072.1 1725421 1725494 R tRNA-Ile complement(1725421..1725494) Streptococcus pneumoniae G54 6480500 SPG_1790 tRNA SPG_1790 NC_011072.1 1725530 1725600 R tRNA-Gly complement(1725530..1725600) Streptococcus pneumoniae G54 6480402 SPG_1791 tRNA SPG_1791 NC_011072.1 1725620 1725692 R tRNA-Phe complement(1725620..1725692) Streptococcus pneumoniae G54 6480330 SPG_1792 tRNA SPG_1792 NC_011072.1 1725696 1725769 R tRNA-Met complement(1725696..1725769) Streptococcus pneumoniae G54 6480688 SPG_1793 tRNA SPG_1793 NC_011072.1 1725780 1725869 R tRNA-Ser complement(1725780..1725869) Streptococcus pneumoniae G54 6478780 SPG_1794 tRNA SPG_1794 NC_011072.1 1725880 1725953 R tRNA-Met complement(1725880..1725953) Streptococcus pneumoniae G54 6480286 SPG_1795 tRNA SPG_1795 NC_011072.1 1725967 1726040 R tRNA-Met complement(1725967..1726040) Streptococcus pneumoniae G54 6480690 SPG_1796 tRNA SPG_1796 NC_011072.1 1726046 1726119 R tRNA-Pro complement(1726046..1726119) Streptococcus pneumoniae G54 6480615 SPG_1797 tRNA SPG_1797 NC_011072.1 1726135 1726208 R tRNA-Arg complement(1726135..1726208) Streptococcus pneumoniae G54 6480005 SPG_1798 tRNA SPG_1798 NC_011072.1 1726218 1726303 R tRNA-Leu complement(1726218..1726303) Streptococcus pneumoniae G54 6480233 SPG_1799 tRNA SPG_1799 NC_011072.1 1726311 1726382 R tRNA-Gly complement(1726311..1726382) Streptococcus pneumoniae G54 6480604 SPG_1800 tRNA SPG_1800 NC_011072.1 1726405 1726477 R tRNA-Thr complement(1726405..1726477) Streptococcus pneumoniae G54 6479943 SPG_1801 tRNA SPG_1801 NC_011072.1 1726496 1726578 R tRNA-Leu complement(1726496..1726578) Streptococcus pneumoniae G54 6479918 SPG_1802 tRNA SPG_1802 NC_011072.1 1726584 1726656 R tRNA-Lys complement(1726584..1726656) Streptococcus pneumoniae G54 6480403 SPG_1803 tRNA SPG_1803 NC_011072.1 1726681 1726753 R tRNA-Asp complement(1726681..1726753) Streptococcus pneumoniae G54 6480691 SPG_1804 tRNA SPG_1804 NC_011072.1 1726756 1726828 R tRNA-Val complement(1726756..1726828) Streptococcus pneumoniae G54 6478981 SPG_1807 tRNA SPG_1807 NC_011072.1 1730051 1730123 R tRNA-Ala complement(1730051..1730123) Streptococcus pneumoniae G54 6480554 SPG_1809 tRNA SPG_1809 NC_011072.1 1731973 1732044 R tRNA-Glu complement(1731973..1732044) Streptococcus pneumoniae G54 6480759 SPG_1863 tRNA SPG_1863 NC_011072.1 1780725 1780795 D tRNA-Cys 1780725..1780795 Streptococcus pneumoniae G54 6479822 SPG_1908 tRNA SPG_1908 NC_011072.1 1818173 1818246 R tRNA-Pro complement(1818173..1818246) Streptococcus pneumoniae G54 6478963 SPG_1909 tRNA SPG_1909 NC_011072.1 1818262 1818335 R tRNA-Arg complement(1818262..1818335) Streptococcus pneumoniae G54 6480817 SPG_1910 tRNA SPG_1910 NC_011072.1 1818345 1818430 R tRNA-Leu complement(1818345..1818430) Streptococcus pneumoniae G54 6480499 SPG_1911 tRNA SPG_1911 NC_011072.1 1818438 1818509 R tRNA-Gly complement(1818438..1818509) Streptococcus pneumoniae G54 6480419 SPG_1912 tRNA SPG_1912 NC_011072.1 1818532 1818604 R tRNA-Thr complement(1818532..1818604) Streptococcus pneumoniae G54 6480354 SPG_1913 tRNA SPG_1913 NC_011072.1 1818623 1818704 R tRNA-Leu complement(1818623..1818704) Streptococcus pneumoniae G54 6480684 SPG_1914 tRNA SPG_1914 NC_011072.1 1818710 1818782 R tRNA-Lys complement(1818710..1818782) Streptococcus pneumoniae G54 6480360 SPG_1915 tRNA SPG_1915 NC_011072.1 1818807 1818879 R tRNA-Asp complement(1818807..1818879) Streptococcus pneumoniae G54 6480453 SPG_1916 tRNA SPG_1916 NC_011072.1 1818882 1818954 R tRNA-Val complement(1818882..1818954) Streptococcus pneumoniae G54 6480689 SPG_1919 tRNA SPG_1919 NC_011072.1 1822177 1822249 R tRNA-Ala complement(1822177..1822249) Streptococcus pneumoniae G54 6480497 SPG_1921 tRNA SPG_1921 NC_011072.1 1824100 1824171 R tRNA-Glu complement(1824100..1824171) Streptococcus pneumoniae G54 6480687 SPG_1991 tRNA SPG_1991 NC_011072.1 1885307 1885390 R tRNA-Leu complement(1885307..1885390) Streptococcus pneumoniae G54 6480380 SPG_1992 tRNA SPG_1992 NC_011072.1 1885400 1885471 R tRNA-Gln complement(1885400..1885471) Streptococcus pneumoniae G54 6478785 SPG_1993 tRNA SPG_1993 NC_011072.1 1885482 1885554 R tRNA-His complement(1885482..1885554) Streptococcus pneumoniae G54 6478786 SPG_1994 tRNA SPG_1994 NC_011072.1 1885569 1885639 R tRNA-Trp complement(1885569..1885639) Streptococcus pneumoniae G54 6479139 SPG_1995 tRNA SPG_1995 NC_011072.1 1885644 1885724 R tRNA-Tyr complement(1885644..1885724) Streptococcus pneumoniae G54 6480818 SPG_1996 tRNA SPG_1996 NC_011072.1 1885737 1885809 R tRNA-Phe complement(1885737..1885809) Streptococcus pneumoniae G54 6479138 SPG_1997 tRNA SPG_1997 NC_011072.1 1885813 1885886 R tRNA-Met complement(1885813..1885886) Streptococcus pneumoniae G54 6480647 SPG_1998 tRNA SPG_1998 NC_011072.1 1885897 1885986 R tRNA-Ser complement(1885897..1885986) Streptococcus pneumoniae G54 6480175 SPG_1999 tRNA SPG_1999 NC_011072.1 1886069 1886142 R tRNA-Ile complement(1886069..1886142) Streptococcus pneumoniae G54 6479653 SPG_2000 tRNA SPG_2000 NC_011072.1 1886180 1886249 R tRNA-Asp complement(1886180..1886249) Streptococcus pneumoniae G54 6479944 SPG_2001 tRNA SPG_2001 NC_011072.1 1886252 1886324 R tRNA-Val complement(1886252..1886324) Streptococcus pneumoniae G54 6480287 SPG_2004 tRNA SPG_2004 NC_011072.1 1889547 1889619 R tRNA-Ala complement(1889547..1889619) Streptococcus pneumoniae G54 6480049 SPG_2006 tRNA SPG_2006 NC_011072.1 1891469 1891540 R tRNA-Glu complement(1891469..1891540) Streptococcus pneumoniae G54 6480555 SPG_2181 tRNA SPG_2181 NC_011072.1 2073574 2073647 R tRNA-Asn complement(2073574..2073647) Streptococcus pneumoniae G54 6479339 SPG_2182 tRNA SPG_2182 NC_011072.1 2073653 2073724 R tRNA-Glu complement(2073653..2073724) Streptococcus pneumoniae G54 6480708 SPG_2186 tRNA SPG_2186 NC_011072.1 2076161 2076234 R tRNA-Arg complement(2076161..2076234) Streptococcus pneumoniae G54 6478967 SPG_0016 rRNA rrsA NC_011072.1 15360 16817 D 16S ribosomal RNA 15360..16817 Streptococcus pneumoniae G54 6480176 SPG_0018 rRNA rrlA NC_011072.1 17141 20042 D 23S ribosomal RNA 17141..20042 Streptococcus pneumoniae G54 6480743 SPG_0019 rRNA rrfA NC_011072.1 20119 20234 D 5S ribosomal RNA 20119..20234 Streptococcus pneumoniae G54 6480624 SPG_1805 rRNA rrfB NC_011072.1 1726833 1726948 R 5S ribosomal RNA complement(1726833..1726948) Streptococcus pneumoniae G54 6480133 SPG_1806 rRNA rrlB NC_011072.1 1727025 1729926 R 23S ribosomal RNA complement(1727025..1729926) Streptococcus pneumoniae G54 6480050 SPG_1808 rRNA rrsB NC_011072.1 1730250 1731707 R 16S ribosomal RNA complement(1730250..1731707) Streptococcus pneumoniae G54 6480742 SPG_1917 rRNA rrfC NC_011072.1 1818959 1819074 R 5S ribosomal RNA complement(1818959..1819074) Streptococcus pneumoniae G54 6480234 SPG_1918 rRNA rrlC NC_011072.1 1819151 1822052 R 23S ribosomal RNA complement(1819151..1822052) Streptococcus pneumoniae G54 6480625 SPG_1920 rRNA rrsC NC_011072.1 1822376 1823833 R 16S ribosomal RNA complement(1822376..1823833) Streptococcus pneumoniae G54 6480359 SPG_2002 rRNA rrfD NC_011072.1 1886329 1886444 R 5S ribosomal RNA complement(1886329..1886444) Streptococcus pneumoniae G54 6480112 SPG_2003 rRNA rrlD NC_011072.1 1886521 1889422 R 23S ribosomal RNA complement(1886521..1889422) Streptococcus pneumoniae G54 6480679 SPG_2005 rRNA rrsD NC_011072.1 1889746 1891203 R 16S ribosomal RNA complement(1889746..1891203) Streptococcus pneumoniae G54 6479919