-- dump date 20140620_084542 -- class Genbank::misc_feature -- table misc_feature_note -- id note 512566000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 512566000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512566000003 Walker A motif; other site 512566000004 ATP binding site [chemical binding]; other site 512566000005 Walker B motif; other site 512566000006 arginine finger; other site 512566000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 512566000008 DnaA box-binding interface [nucleotide binding]; other site 512566000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 512566000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 512566000011 putative DNA binding surface [nucleotide binding]; other site 512566000012 dimer interface [polypeptide binding]; other site 512566000013 beta-clamp/clamp loader binding surface; other site 512566000014 beta-clamp/translesion DNA polymerase binding surface; other site 512566000015 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 512566000016 GTP-binding protein YchF; Reviewed; Region: PRK09601 512566000017 YchF GTPase; Region: YchF; cd01900 512566000018 G1 box; other site 512566000019 GTP/Mg2+ binding site [chemical binding]; other site 512566000020 Switch I region; other site 512566000021 G2 box; other site 512566000022 Switch II region; other site 512566000023 G3 box; other site 512566000024 G4 box; other site 512566000025 G5 box; other site 512566000026 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 512566000027 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 512566000028 putative active site [active] 512566000029 catalytic residue [active] 512566000030 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 512566000031 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 512566000032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512566000033 ATP binding site [chemical binding]; other site 512566000034 putative Mg++ binding site [ion binding]; other site 512566000035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512566000036 nucleotide binding region [chemical binding]; other site 512566000037 ATP-binding site [chemical binding]; other site 512566000038 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 512566000039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512566000040 RNA binding surface [nucleotide binding]; other site 512566000041 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 512566000042 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 512566000043 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 512566000044 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 512566000045 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 512566000046 Ligand Binding Site [chemical binding]; other site 512566000047 TilS substrate C-terminal domain; Region: TilS_C; smart00977 512566000048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512566000049 active site 512566000050 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 512566000051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512566000052 Walker A motif; other site 512566000053 ATP binding site [chemical binding]; other site 512566000054 Walker B motif; other site 512566000055 arginine finger; other site 512566000056 Peptidase family M41; Region: Peptidase_M41; pfam01434 512566000057 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512566000058 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 512566000059 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 512566000060 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 512566000061 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 512566000062 GDP-binding site [chemical binding]; other site 512566000063 ACT binding site; other site 512566000064 IMP binding site; other site 512566000065 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 512566000066 nucleoside/Zn binding site; other site 512566000067 dimer interface [polypeptide binding]; other site 512566000068 catalytic motif [active] 512566000069 Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes. All members...; Region: cytidine_deaminase-like; cl00269 512566000070 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 512566000071 trimer interface [polypeptide binding]; other site 512566000072 active site 512566000073 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512566000074 catalytic core [active] 512566000075 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 512566000076 DNA repair protein RadA; Provisional; Region: PRK11823 512566000077 Walker A motif; other site 512566000078 ATP binding site [chemical binding]; other site 512566000079 Walker B motif; other site 512566000080 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 512566000081 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 512566000082 active site clefts [active] 512566000083 zinc binding site [ion binding]; other site 512566000084 dimer interface [polypeptide binding]; other site 512566000085 Protease prsW family; Region: PrsW-protease; cl15823 512566000086 Protease prsW family; Region: PrsW-protease; cl15823 512566000087 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 512566000088 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 512566000089 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512566000090 active site 512566000091 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 512566000092 DNA polymerase I; Provisional; Region: PRK05755 512566000093 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 512566000094 active site 512566000095 metal binding site 1 [ion binding]; metal-binding site 512566000096 putative 5' ssDNA interaction site; other site 512566000097 metal binding site 3; metal-binding site 512566000098 metal binding site 2 [ion binding]; metal-binding site 512566000099 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 512566000100 putative DNA binding site [nucleotide binding]; other site 512566000101 putative metal binding site [ion binding]; other site 512566000102 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 512566000103 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 512566000104 active site 512566000105 DNA binding site [nucleotide binding] 512566000106 catalytic site [active] 512566000107 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 512566000108 Predicted membrane protein [Function unknown]; Region: COG2855 512566000109 aromatic amino acid aminotransferase; Validated; Region: PRK07309 512566000110 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512566000111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512566000112 homodimer interface [polypeptide binding]; other site 512566000113 catalytic residue [active] 512566000114 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 512566000115 Recombination protein O N terminal; Region: RecO_N; pfam11967 512566000116 Recombination protein O C terminal; Region: RecO_C; pfam02565 512566000117 putative phosphate acyltransferase; Provisional; Region: PRK05331 512566000118 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 512566000119 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 512566000120 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 512566000121 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 512566000122 putative active site [active] 512566000123 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512566000124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566000125 Walker A/P-loop; other site 512566000126 ATP binding site [chemical binding]; other site 512566000127 Q-loop/lid; other site 512566000128 ABC transporter signature motif; other site 512566000129 Walker B; other site 512566000130 D-loop; other site 512566000131 H-loop/switch region; other site 512566000132 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 512566000133 HlyD family secretion protein; Region: HlyD_3; pfam13437 512566000134 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 512566000135 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 512566000136 ATP binding site [chemical binding]; other site 512566000137 active site 512566000138 substrate binding site [chemical binding]; other site 512566000139 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 512566000140 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 512566000141 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 512566000142 dimerization interface [polypeptide binding]; other site 512566000143 ATP binding site [chemical binding]; other site 512566000144 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 512566000145 dimerization interface [polypeptide binding]; other site 512566000146 ATP binding site [chemical binding]; other site 512566000147 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 512566000148 putative active site [active] 512566000149 catalytic triad [active] 512566000150 amidophosphoribosyltransferase; Provisional; Region: PRK07272 512566000151 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 512566000152 active site 512566000153 tetramer interface [polypeptide binding]; other site 512566000154 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512566000155 active site 512566000156 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 512566000157 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 512566000158 dimerization interface [polypeptide binding]; other site 512566000159 putative ATP binding site [chemical binding]; other site 512566000160 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 512566000161 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 512566000162 active site 512566000163 substrate binding site [chemical binding]; other site 512566000164 cosubstrate binding site; other site 512566000165 catalytic site [active] 512566000166 VanZ like family; Region: VanZ; pfam04892 512566000167 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 512566000168 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 512566000169 purine monophosphate binding site [chemical binding]; other site 512566000170 dimer interface [polypeptide binding]; other site 512566000171 putative catalytic residues [active] 512566000172 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 512566000173 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 512566000174 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 512566000175 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 512566000176 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 512566000177 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 512566000178 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 512566000179 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 512566000180 ATP-grasp domain; Region: ATP-grasp; pfam02222 512566000181 adenylosuccinate lyase; Provisional; Region: PRK07492 512566000182 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 512566000183 tetramer interface [polypeptide binding]; other site 512566000184 active site 512566000185 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 512566000186 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 512566000187 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 512566000188 active site 512566000189 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 512566000190 active site 512566000191 G5 domain; Region: G5; pfam07501 512566000192 G5 domain; Region: G5; pfam07501 512566000193 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 512566000194 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 512566000195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512566000196 DNA-binding site [nucleotide binding]; DNA binding site 512566000197 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 512566000198 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 512566000199 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 512566000200 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 512566000201 active site 512566000202 phosphorylation site [posttranslational modification] 512566000203 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 512566000204 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 512566000205 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 512566000206 active pocket/dimerization site; other site 512566000207 active site 512566000208 phosphorylation site [posttranslational modification] 512566000209 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 512566000210 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 512566000211 dimer interface [polypeptide binding]; other site 512566000212 active site 512566000213 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 512566000214 putative active site [active] 512566000215 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 512566000216 active site 512566000217 catalytic residues [active] 512566000218 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 512566000219 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 512566000220 G5 domain; Region: G5; pfam07501 512566000221 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 512566000222 The GLUG motif; Region: Glug; pfam07581 512566000223 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 512566000224 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 512566000225 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 512566000226 putative metal binding site [ion binding]; other site 512566000227 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 512566000228 active site 512566000229 maltose O-acetyltransferase; Provisional; Region: PRK10092 512566000230 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 512566000231 active site 512566000232 substrate binding site [chemical binding]; other site 512566000233 trimer interface [polypeptide binding]; other site 512566000234 CoA binding site [chemical binding]; other site 512566000235 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 512566000236 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 512566000237 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 512566000238 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 512566000239 TrkA-N domain; Region: TrkA_N; pfam02254 512566000240 Fibronectin-binding repeat; Region: SSURE; pfam11966 512566000241 Fibronectin-binding repeat; Region: SSURE; pfam11966 512566000242 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512566000243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512566000244 active site 512566000245 phosphorylation site [posttranslational modification] 512566000246 intermolecular recognition site; other site 512566000247 dimerization interface [polypeptide binding]; other site 512566000248 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512566000249 DNA binding site [nucleotide binding] 512566000250 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512566000251 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512566000252 dimerization interface [polypeptide binding]; other site 512566000253 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512566000254 dimer interface [polypeptide binding]; other site 512566000255 phosphorylation site [posttranslational modification] 512566000256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566000257 ATP binding site [chemical binding]; other site 512566000258 Mg2+ binding site [ion binding]; other site 512566000259 G-X-G motif; other site 512566000260 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 512566000261 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 512566000262 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512566000263 RNA binding surface [nucleotide binding]; other site 512566000264 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 512566000265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566000266 dimer interface [polypeptide binding]; other site 512566000267 conserved gate region; other site 512566000268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512566000269 ABC-ATPase subunit interface; other site 512566000270 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512566000271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566000272 dimer interface [polypeptide binding]; other site 512566000273 conserved gate region; other site 512566000274 putative PBP binding loops; other site 512566000275 ABC-ATPase subunit interface; other site 512566000276 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512566000277 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 512566000278 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 512566000279 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 512566000280 active site residue [active] 512566000281 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 512566000282 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 512566000283 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 512566000284 Predicted membrane protein [Function unknown]; Region: COG4709 512566000285 Predicted transcriptional regulators [Transcription]; Region: COG1695 512566000286 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 512566000287 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 512566000288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512566000289 putative substrate translocation pore; other site 512566000290 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 512566000291 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 512566000292 Ligand binding site; other site 512566000293 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 512566000294 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512566000295 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 512566000296 NAD(P) binding site [chemical binding]; other site 512566000297 homodimer interface [polypeptide binding]; other site 512566000298 substrate binding site [chemical binding]; other site 512566000299 active site 512566000300 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 512566000301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566000302 active site 512566000303 motif I; other site 512566000304 motif II; other site 512566000305 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 512566000306 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 512566000307 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 512566000308 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 512566000309 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 512566000310 putative L-serine binding site [chemical binding]; other site 512566000311 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 512566000312 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 512566000313 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 512566000314 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512566000315 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 512566000316 Walker A/P-loop; other site 512566000317 ATP binding site [chemical binding]; other site 512566000318 Q-loop/lid; other site 512566000319 ABC transporter signature motif; other site 512566000320 Walker B; other site 512566000321 D-loop; other site 512566000322 H-loop/switch region; other site 512566000323 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512566000324 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 512566000325 substrate binding pocket [chemical binding]; other site 512566000326 membrane-bound complex binding site; other site 512566000327 hinge residues; other site 512566000328 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 512566000329 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566000330 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 512566000331 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566000332 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566000333 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566000334 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566000335 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 512566000336 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566000337 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566000338 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 512566000339 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566000340 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 512566000341 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 512566000342 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 512566000343 nudix motif; other site 512566000344 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 512566000345 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 512566000346 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 512566000347 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 512566000348 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 512566000349 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 512566000350 hypothetical protein; Provisional; Region: PRK13667 512566000351 class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949 512566000352 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 512566000353 Glycoprotease family; Region: Peptidase_M22; pfam00814 512566000354 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 512566000355 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512566000356 Coenzyme A binding pocket [chemical binding]; other site 512566000357 UGMP family protein; Validated; Region: PRK09604 512566000358 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 512566000359 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 512566000360 Transposase; Region: DDE_Tnp_ISL3; pfam01610 512566000361 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 512566000362 Helix-turn-helix domain; Region: HTH_38; pfam13936 512566000363 Transposase; Region: DDE_Tnp_ISL3; pfam01610 512566000364 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512566000365 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512566000366 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 512566000367 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 512566000368 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 512566000369 active site 512566000370 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512566000371 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 512566000372 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512566000373 Walker A/P-loop; other site 512566000374 ATP binding site [chemical binding]; other site 512566000375 Q-loop/lid; other site 512566000376 ABC transporter signature motif; other site 512566000377 Walker B; other site 512566000378 D-loop; other site 512566000379 H-loop/switch region; other site 512566000380 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 512566000381 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 512566000382 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 512566000383 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 512566000384 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 512566000385 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 512566000386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566000387 non-specific DNA binding site [nucleotide binding]; other site 512566000388 salt bridge; other site 512566000389 sequence-specific DNA binding site [nucleotide binding]; other site 512566000390 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 512566000391 CAAX protease self-immunity; Region: Abi; pfam02517 512566000392 CAAX protease self-immunity; Region: Abi; pfam02517 512566000393 H+ Antiporter protein; Region: 2A0121; TIGR00900 512566000394 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 512566000395 Predicted membrane protein [Function unknown]; Region: COG4392 512566000396 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 512566000397 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512566000398 substrate binding pocket [chemical binding]; other site 512566000399 membrane-bound complex binding site; other site 512566000400 hinge residues; other site 512566000401 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 512566000402 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 512566000403 hypothetical protein; Provisional; Region: PRK06446 512566000404 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 512566000405 metal binding site [ion binding]; metal-binding site 512566000406 dimer interface [polypeptide binding]; other site 512566000407 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 512566000408 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 512566000409 Walker A/P-loop; other site 512566000410 ATP binding site [chemical binding]; other site 512566000411 Q-loop/lid; other site 512566000412 ABC transporter signature motif; other site 512566000413 Walker B; other site 512566000414 D-loop; other site 512566000415 H-loop/switch region; other site 512566000416 NIL domain; Region: NIL; pfam09383 512566000417 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 512566000418 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 512566000419 Protein of unknown function, DUF624; Region: DUF624; cl02369 512566000420 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 512566000421 HAMP domain; Region: HAMP; pfam00672 512566000422 Histidine kinase; Region: His_kinase; pfam06580 512566000423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566000424 ATP binding site [chemical binding]; other site 512566000425 Mg2+ binding site [ion binding]; other site 512566000426 G-X-G motif; other site 512566000427 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 512566000428 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512566000429 active site 512566000430 phosphorylation site [posttranslational modification] 512566000431 intermolecular recognition site; other site 512566000432 dimerization interface [polypeptide binding]; other site 512566000433 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512566000434 flavoprotein NrdI; Provisional; Region: PRK02551 512566000435 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 512566000436 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 512566000437 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 512566000438 LytTr DNA-binding domain; Region: LytTR; smart00850 512566000439 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 512566000440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566000441 ATP binding site [chemical binding]; other site 512566000442 Mg2+ binding site [ion binding]; other site 512566000443 G-X-G motif; other site 512566000444 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 512566000445 ATP binding site [chemical binding]; other site 512566000446 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 512566000447 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 512566000448 homopentamer interface [polypeptide binding]; other site 512566000449 active site 512566000450 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 512566000451 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 512566000452 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 512566000453 dimerization interface [polypeptide binding]; other site 512566000454 active site 512566000455 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 512566000456 Lumazine binding domain; Region: Lum_binding; pfam00677 512566000457 Lumazine binding domain; Region: Lum_binding; pfam00677 512566000458 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 512566000459 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 512566000460 catalytic motif [active] 512566000461 Zn binding site [ion binding]; other site 512566000462 RibD C-terminal domain; Region: RibD_C; cl17279 512566000463 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 512566000464 RuvA N terminal domain; Region: RuvA_N; pfam01330 512566000465 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 512566000466 CAAX protease self-immunity; Region: Abi; pfam02517 512566000467 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 512566000468 putative dimer interface [polypeptide binding]; other site 512566000469 catalytic triad [active] 512566000470 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 512566000471 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 512566000472 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 512566000473 Cl binding site [ion binding]; other site 512566000474 oligomer interface [polypeptide binding]; other site 512566000475 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 512566000476 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 512566000477 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 512566000478 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 512566000479 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 512566000480 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 512566000481 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 512566000482 active site 512566000483 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 512566000484 ArsC family; Region: ArsC; pfam03960 512566000485 putative catalytic residues [active] 512566000486 thiol/disulfide switch; other site 512566000487 hypothetical protein; Provisional; Region: PRK05473 512566000488 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 512566000489 hypothetical protein; Provisional; Region: PRK13678 512566000490 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 512566000491 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 512566000492 Bacterial lipoprotein; Region: DUF3642; pfam12182 512566000493 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 512566000494 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 512566000495 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 512566000496 putative active site [active] 512566000497 catalytic site [active] 512566000498 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 512566000499 putative active site [active] 512566000500 catalytic site [active] 512566000501 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 512566000502 ATP cone domain; Region: ATP-cone; pfam03477 512566000503 Class III ribonucleotide reductase; Region: RNR_III; cd01675 512566000504 effector binding site; other site 512566000505 active site 512566000506 Zn binding site [ion binding]; other site 512566000507 glycine loop; other site 512566000508 Predicted acetyltransferase [General function prediction only]; Region: COG3981 512566000509 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512566000510 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 512566000511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512566000512 FeS/SAM binding site; other site 512566000513 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 512566000514 active site 512566000515 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 512566000516 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 512566000517 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 512566000518 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 512566000519 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 512566000520 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 512566000521 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 512566000522 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 512566000523 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 512566000524 putative translocon binding site; other site 512566000525 protein-rRNA interface [nucleotide binding]; other site 512566000526 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 512566000527 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 512566000528 G-X-X-G motif; other site 512566000529 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 512566000530 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 512566000531 23S rRNA interface [nucleotide binding]; other site 512566000532 5S rRNA interface [nucleotide binding]; other site 512566000533 putative antibiotic binding site [chemical binding]; other site 512566000534 L25 interface [polypeptide binding]; other site 512566000535 L27 interface [polypeptide binding]; other site 512566000536 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 512566000537 23S rRNA interface [nucleotide binding]; other site 512566000538 putative translocon interaction site; other site 512566000539 signal recognition particle (SRP54) interaction site; other site 512566000540 L23 interface [polypeptide binding]; other site 512566000541 trigger factor interaction site; other site 512566000542 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 512566000543 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 512566000544 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 512566000545 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 512566000546 RNA binding site [nucleotide binding]; other site 512566000547 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 512566000548 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 512566000549 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 512566000550 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 512566000551 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 512566000552 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 512566000553 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 512566000554 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 512566000555 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 512566000556 5S rRNA interface [nucleotide binding]; other site 512566000557 L27 interface [polypeptide binding]; other site 512566000558 23S rRNA interface [nucleotide binding]; other site 512566000559 L5 interface [polypeptide binding]; other site 512566000560 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 512566000561 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 512566000562 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 512566000563 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 512566000564 23S rRNA binding site [nucleotide binding]; other site 512566000565 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 512566000566 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 512566000567 SecY translocase; Region: SecY; pfam00344 512566000568 adenylate kinase; Reviewed; Region: adk; PRK00279 512566000569 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 512566000570 AMP-binding site [chemical binding]; other site 512566000571 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 512566000572 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 512566000573 rRNA binding site [nucleotide binding]; other site 512566000574 predicted 30S ribosome binding site; other site 512566000575 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 512566000576 30S ribosomal protein S11; Validated; Region: PRK05309 512566000577 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 512566000578 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 512566000579 alphaNTD homodimer interface [polypeptide binding]; other site 512566000580 alphaNTD - beta interaction site [polypeptide binding]; other site 512566000581 alphaNTD - beta' interaction site [polypeptide binding]; other site 512566000582 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 512566000583 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 512566000584 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 512566000585 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 512566000586 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512566000587 catalytic core [active] 512566000588 putative PBP binding loops; other site 512566000589 dimer interface [polypeptide binding]; other site 512566000590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512566000591 ABC-ATPase subunit interface; other site 512566000592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512566000593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512566000594 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 512566000595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566000596 Walker A/P-loop; other site 512566000597 ATP binding site [chemical binding]; other site 512566000598 Q-loop/lid; other site 512566000599 ABC transporter signature motif; other site 512566000600 Walker B; other site 512566000601 D-loop; other site 512566000602 H-loop/switch region; other site 512566000603 TOBE domain; Region: TOBE_2; pfam08402 512566000604 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 512566000605 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 512566000606 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512566000607 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512566000608 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 512566000609 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 512566000610 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 512566000611 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 512566000612 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 512566000613 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 512566000614 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 512566000615 active site 512566000616 methionine cluster; other site 512566000617 phosphorylation site [posttranslational modification] 512566000618 metal binding site [ion binding]; metal-binding site 512566000619 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 512566000620 active site 512566000621 P-loop; other site 512566000622 phosphorylation site [posttranslational modification] 512566000623 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 512566000624 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 512566000625 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 512566000626 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 512566000627 dimer interface [polypeptide binding]; other site 512566000628 active site 512566000629 glycine loop; other site 512566000630 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 512566000631 active site 512566000632 intersubunit interactions; other site 512566000633 catalytic residue [active] 512566000634 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 512566000635 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 512566000636 dimer interface [polypeptide binding]; other site 512566000637 active site 512566000638 metal binding site [ion binding]; metal-binding site 512566000639 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 512566000640 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 512566000641 HIGH motif; other site 512566000642 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 512566000643 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512566000644 active site 512566000645 KMSKS motif; other site 512566000646 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 512566000647 tRNA binding surface [nucleotide binding]; other site 512566000648 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 512566000649 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512566000650 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 512566000651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512566000652 Coenzyme A binding pocket [chemical binding]; other site 512566000653 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 512566000654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512566000655 Walker A motif; other site 512566000656 ATP binding site [chemical binding]; other site 512566000657 Walker B motif; other site 512566000658 arginine finger; other site 512566000659 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 512566000660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 512566000661 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 512566000662 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 512566000663 catalytic residue [active] 512566000664 putative FPP diphosphate binding site; other site 512566000665 putative FPP binding hydrophobic cleft; other site 512566000666 dimer interface [polypeptide binding]; other site 512566000667 putative IPP diphosphate binding site; other site 512566000668 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 512566000669 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 512566000670 RIP metalloprotease RseP; Region: TIGR00054 512566000671 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 512566000672 active site 512566000673 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 512566000674 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 512566000675 putative substrate binding region [chemical binding]; other site 512566000676 prolyl-tRNA synthetase; Provisional; Region: PRK09194 512566000677 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 512566000678 dimer interface [polypeptide binding]; other site 512566000679 motif 1; other site 512566000680 active site 512566000681 motif 2; other site 512566000682 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 512566000683 putative deacylase active site [active] 512566000684 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 512566000685 active site 512566000686 motif 3; other site 512566000687 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 512566000688 anticodon binding site; other site 512566000689 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 512566000690 beta-galactosidase; Region: BGL; TIGR03356 512566000691 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 512566000692 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 512566000693 glutaminase active site [active] 512566000694 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 512566000695 dimer interface [polypeptide binding]; other site 512566000696 active site 512566000697 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 512566000698 dimer interface [polypeptide binding]; other site 512566000699 active site 512566000700 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 512566000701 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 512566000702 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 512566000703 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 512566000704 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 512566000705 carbohydrate binding site [chemical binding]; other site 512566000706 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 512566000707 carbohydrate binding site [chemical binding]; other site 512566000708 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 512566000709 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 512566000710 Ca binding site [ion binding]; other site 512566000711 active site 512566000712 catalytic site [active] 512566000713 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 512566000714 S17 interaction site [polypeptide binding]; other site 512566000715 S8 interaction site; other site 512566000716 16S rRNA interaction site [nucleotide binding]; other site 512566000717 streptomycin interaction site [chemical binding]; other site 512566000718 23S rRNA interaction site [nucleotide binding]; other site 512566000719 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 512566000720 30S ribosomal protein S7; Validated; Region: PRK05302 512566000721 elongation factor G; Reviewed; Region: PRK00007 512566000722 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 512566000723 G1 box; other site 512566000724 putative GEF interaction site [polypeptide binding]; other site 512566000725 GTP/Mg2+ binding site [chemical binding]; other site 512566000726 Switch I region; other site 512566000727 G2 box; other site 512566000728 G3 box; other site 512566000729 Switch II region; other site 512566000730 G4 box; other site 512566000731 G5 box; other site 512566000732 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 512566000733 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 512566000734 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 512566000735 DNA polymerase III PolC; Validated; Region: polC; PRK00448 512566000736 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 512566000737 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 512566000738 generic binding surface II; other site 512566000739 generic binding surface I; other site 512566000740 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 512566000741 active site 512566000742 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 512566000743 active site 512566000744 catalytic site [active] 512566000745 substrate binding site [chemical binding]; other site 512566000746 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 512566000747 putative PHP Thumb interface [polypeptide binding]; other site 512566000748 active site 512566000749 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 512566000750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 512566000751 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 512566000752 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 512566000753 Predicted membrane protein [Function unknown]; Region: COG2261 512566000754 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 512566000755 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512566000756 RNA binding surface [nucleotide binding]; other site 512566000757 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 512566000758 active site 512566000759 uracil binding [chemical binding]; other site 512566000760 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 512566000761 trimer interface [polypeptide binding]; other site 512566000762 active site 512566000763 G bulge; other site 512566000764 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 512566000765 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 512566000766 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 512566000767 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 512566000768 active pocket/dimerization site; other site 512566000769 active site 512566000770 phosphorylation site [posttranslational modification] 512566000771 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 512566000772 active site 512566000773 phosphorylation site [posttranslational modification] 512566000774 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 512566000775 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 512566000776 NAD binding site [chemical binding]; other site 512566000777 substrate binding site [chemical binding]; other site 512566000778 catalytic Zn binding site [ion binding]; other site 512566000779 tetramer interface [polypeptide binding]; other site 512566000780 structural Zn binding site [ion binding]; other site 512566000781 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 512566000782 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 512566000783 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566000784 active site 512566000785 motif I; other site 512566000786 motif II; other site 512566000787 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 512566000788 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 512566000789 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 512566000790 dihydropteroate synthase; Region: DHPS; TIGR01496 512566000791 substrate binding pocket [chemical binding]; other site 512566000792 dimer interface [polypeptide binding]; other site 512566000793 inhibitor binding site; inhibition site 512566000794 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 512566000795 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 512566000796 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 512566000797 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 512566000798 homodecamer interface [polypeptide binding]; other site 512566000799 GTP cyclohydrolase I; Provisional; Region: PLN03044 512566000800 active site 512566000801 putative catalytic site residues [active] 512566000802 zinc binding site [ion binding]; other site 512566000803 GTP-CH-I/GFRP interaction surface; other site 512566000804 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 512566000805 homooctamer interface [polypeptide binding]; other site 512566000806 active site 512566000807 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 512566000808 catalytic center binding site [active] 512566000809 ATP binding site [chemical binding]; other site 512566000810 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 512566000811 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 512566000812 23S rRNA interface [nucleotide binding]; other site 512566000813 L3 interface [polypeptide binding]; other site 512566000814 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 512566000815 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512566000816 DNA binding site [nucleotide binding] 512566000817 active site 512566000818 Int/Topo IB signature motif; other site 512566000819 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 512566000820 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 512566000821 putative active site [active] 512566000822 putative catalytic site [active] 512566000823 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 512566000824 catalytic residues [active] 512566000825 dimer interface [polypeptide binding]; other site 512566000826 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 512566000827 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 512566000828 substrate binding site [chemical binding]; other site 512566000829 catalytic residues [active] 512566000830 Transposase IS200 like; Region: Y1_Tnp; cl00848 512566000831 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 512566000832 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 512566000833 active site 512566000834 intersubunit interface [polypeptide binding]; other site 512566000835 catalytic residue [active] 512566000836 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 512566000837 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 512566000838 substrate binding site [chemical binding]; other site 512566000839 ATP binding site [chemical binding]; other site 512566000840 hypothetical protein; Provisional; Region: PRK09273 512566000841 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 512566000842 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 512566000843 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 512566000844 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 512566000845 NADP binding site [chemical binding]; other site 512566000846 homodimer interface [polypeptide binding]; other site 512566000847 active site 512566000848 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 512566000849 active pocket/dimerization site; other site 512566000850 active site 512566000851 phosphorylation site [posttranslational modification] 512566000852 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 512566000853 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 512566000854 active site 512566000855 phosphorylation site [posttranslational modification] 512566000856 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 512566000857 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 512566000858 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 512566000859 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 512566000860 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512566000861 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512566000862 DNA binding site [nucleotide binding] 512566000863 domain linker motif; other site 512566000864 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 512566000865 putative dimerization interface [polypeptide binding]; other site 512566000866 putative ligand binding site [chemical binding]; other site 512566000867 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 512566000868 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566000869 non-specific DNA binding site [nucleotide binding]; other site 512566000870 salt bridge; other site 512566000871 sequence-specific DNA binding site [nucleotide binding]; other site 512566000872 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 512566000873 MraW methylase family; Region: Methyltransf_5; pfam01795 512566000874 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 512566000875 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 512566000876 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 512566000877 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 512566000878 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 512566000879 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 512566000880 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 512566000881 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 512566000882 Mg++ binding site [ion binding]; other site 512566000883 putative catalytic motif [active] 512566000884 putative substrate binding site [chemical binding]; other site 512566000885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512566000886 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 512566000887 Walker A motif; other site 512566000888 ATP binding site [chemical binding]; other site 512566000889 Walker B motif; other site 512566000890 arginine finger; other site 512566000891 UvrB/uvrC motif; Region: UVR; pfam02151 512566000892 MoxR-like ATPases [General function prediction only]; Region: COG0714 512566000893 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512566000894 Walker A motif; other site 512566000895 ATP binding site [chemical binding]; other site 512566000896 Walker B motif; other site 512566000897 arginine finger; other site 512566000898 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 512566000899 LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854 512566000900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 512566000901 hypothetical protein; Provisional; Region: PRK13663 512566000902 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 512566000903 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 512566000904 Ca binding site [ion binding]; other site 512566000905 active site 512566000906 catalytic site [active] 512566000907 DNA polymerase processivity factor; Region: DNA_PPF; pfam02916 512566000908 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 512566000909 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 512566000910 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 512566000911 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 512566000912 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 512566000913 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 512566000914 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 512566000915 Bacterial sugar transferase; Region: Bac_transf; pfam02397 512566000916 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 512566000917 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 512566000918 LicD family; Region: LicD; pfam04991 512566000919 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 512566000920 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 512566000921 active site 512566000922 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 512566000923 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 512566000924 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 512566000925 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 512566000926 active site 512566000927 homodimer interface [polypeptide binding]; other site 512566000928 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 512566000929 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 512566000930 substrate binding site; other site 512566000931 tetramer interface; other site 512566000932 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 512566000933 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 512566000934 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 512566000935 NAD binding site [chemical binding]; other site 512566000936 substrate binding site [chemical binding]; other site 512566000937 homodimer interface [polypeptide binding]; other site 512566000938 active site 512566000939 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 512566000940 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 512566000941 NADP binding site [chemical binding]; other site 512566000942 active site 512566000943 putative substrate binding site [chemical binding]; other site 512566000944 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 512566000945 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 512566000946 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 512566000947 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 512566000948 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 512566000949 peptide binding site [polypeptide binding]; other site 512566000950 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 512566000951 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 512566000952 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512566000953 Transglycosylase; Region: Transgly; pfam00912 512566000954 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 512566000955 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 512566000956 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 512566000957 hypothetical protein; Provisional; Region: PRK13660 512566000958 cell division protein GpsB; Provisional; Region: PRK14127 512566000959 DivIVA domain; Region: DivI1A_domain; TIGR03544 512566000960 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 512566000961 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 512566000962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 512566000963 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 512566000964 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 512566000965 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 512566000966 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512566000967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512566000968 active site 512566000969 phosphorylation site [posttranslational modification] 512566000970 intermolecular recognition site; other site 512566000971 dimerization interface [polypeptide binding]; other site 512566000972 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512566000973 DNA binding site [nucleotide binding] 512566000974 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 512566000975 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 512566000976 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 512566000977 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 512566000978 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 512566000979 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 512566000980 diphosphomevalonate decarboxylase; Region: PLN02407 512566000981 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 512566000982 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 512566000983 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 512566000984 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 512566000985 homotetramer interface [polypeptide binding]; other site 512566000986 FMN binding site [chemical binding]; other site 512566000987 homodimer contacts [polypeptide binding]; other site 512566000988 putative active site [active] 512566000989 putative substrate binding site [chemical binding]; other site 512566000990 Predicted membrane protein [Function unknown]; Region: COG4758 512566000991 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 512566000992 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512566000993 Histidine kinase; Region: HisKA_3; pfam07730 512566000994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566000995 ATP binding site [chemical binding]; other site 512566000996 Mg2+ binding site [ion binding]; other site 512566000997 G-X-G motif; other site 512566000998 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512566000999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512566001000 active site 512566001001 phosphorylation site [posttranslational modification] 512566001002 intermolecular recognition site; other site 512566001003 dimerization interface [polypeptide binding]; other site 512566001004 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512566001005 DNA binding residues [nucleotide binding] 512566001006 dimerization interface [polypeptide binding]; other site 512566001007 A new structural DNA glycosylase; Region: AlkD_like; cl11434 512566001008 A new structural DNA glycosylase; Region: AlkD_like; cl11434 512566001009 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 512566001010 active site 512566001011 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 512566001012 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 512566001013 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566001014 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566001015 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 512566001016 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 512566001017 Integrase core domain; Region: rve_2; pfam13333 512566001018 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 512566001019 Integrase core domain; Region: rve; pfam00665 512566001020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 512566001021 Helix-turn-helix domain; Region: HTH_28; pfam13518 512566001022 Transposase; Region: HTH_Tnp_1; cl17663 512566001023 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 512566001024 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 512566001025 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 512566001026 active site 512566001027 P-loop; other site 512566001028 phosphorylation site [posttranslational modification] 512566001029 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 512566001030 active site 512566001031 P-loop; other site 512566001032 phosphorylation site [posttranslational modification] 512566001033 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 512566001034 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 512566001035 active site 512566001036 P-loop; other site 512566001037 phosphorylation site [posttranslational modification] 512566001038 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 512566001039 active site 512566001040 phosphorylation site [posttranslational modification] 512566001041 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 512566001042 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 512566001043 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 512566001044 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 512566001045 trigger factor; Provisional; Region: tig; PRK01490 512566001046 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 512566001047 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 512566001048 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 512566001049 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 512566001050 DNA binding site [nucleotide binding] 512566001051 AAA domain; Region: AAA_30; pfam13604 512566001052 Family description; Region: UvrD_C_2; pfam13538 512566001053 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 512566001054 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 512566001055 Catalytic site [active] 512566001056 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 512566001057 ribonuclease HIII; Provisional; Region: PRK00996 512566001058 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 512566001059 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 512566001060 RNA/DNA hybrid binding site [nucleotide binding]; other site 512566001061 active site 512566001062 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 512566001063 Colicin V production protein; Region: Colicin_V; pfam02674 512566001064 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 512566001065 MutS domain III; Region: MutS_III; pfam05192 512566001066 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 512566001067 Walker A/P-loop; other site 512566001068 ATP binding site [chemical binding]; other site 512566001069 Q-loop/lid; other site 512566001070 ABC transporter signature motif; other site 512566001071 Walker B; other site 512566001072 D-loop; other site 512566001073 H-loop/switch region; other site 512566001074 Smr domain; Region: Smr; pfam01713 512566001075 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 512566001076 amino acid carrier protein; Region: agcS; TIGR00835 512566001077 Uncharacterized conserved protein [Function unknown]; Region: COG2128 512566001078 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 512566001079 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 512566001080 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 512566001081 gating phenylalanine in ion channel; other site 512566001082 seryl-tRNA synthetase; Provisional; Region: PRK05431 512566001083 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 512566001084 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 512566001085 dimer interface [polypeptide binding]; other site 512566001086 active site 512566001087 motif 1; other site 512566001088 motif 2; other site 512566001089 motif 3; other site 512566001090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 512566001091 aspartate kinase; Reviewed; Region: PRK09034 512566001092 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 512566001093 putative catalytic residues [active] 512566001094 putative nucleotide binding site [chemical binding]; other site 512566001095 putative aspartate binding site [chemical binding]; other site 512566001096 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 512566001097 allosteric regulatory residue; other site 512566001098 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 512566001099 enoyl-CoA hydratase; Provisional; Region: PRK07260 512566001100 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 512566001101 substrate binding site [chemical binding]; other site 512566001102 oxyanion hole (OAH) forming residues; other site 512566001103 trimer interface [polypeptide binding]; other site 512566001104 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512566001105 MarR family; Region: MarR_2; pfam12802 512566001106 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 512566001107 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 512566001108 dimer interface [polypeptide binding]; other site 512566001109 active site 512566001110 CoA binding pocket [chemical binding]; other site 512566001111 acyl carrier protein; Provisional; Region: acpP; PRK00982 512566001112 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 512566001113 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 512566001114 FMN binding site [chemical binding]; other site 512566001115 substrate binding site [chemical binding]; other site 512566001116 putative catalytic residue [active] 512566001117 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 512566001118 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 512566001119 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 512566001120 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 512566001121 NAD(P) binding site [chemical binding]; other site 512566001122 homotetramer interface [polypeptide binding]; other site 512566001123 homodimer interface [polypeptide binding]; other site 512566001124 active site 512566001125 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 512566001126 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 512566001127 dimer interface [polypeptide binding]; other site 512566001128 active site 512566001129 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 512566001130 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 512566001131 carboxyltransferase (CT) interaction site; other site 512566001132 biotinylation site [posttranslational modification]; other site 512566001133 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 512566001134 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 512566001135 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 512566001136 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 512566001137 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 512566001138 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 512566001139 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 512566001140 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 512566001141 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 512566001142 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 512566001143 putative RNA binding site [nucleotide binding]; other site 512566001144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 512566001145 elongation factor P; Validated; Region: PRK00529 512566001146 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 512566001147 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 512566001148 RNA binding site [nucleotide binding]; other site 512566001149 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 512566001150 RNA binding site [nucleotide binding]; other site 512566001151 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 512566001152 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 512566001153 GatB domain; Region: GatB_Yqey; pfam02637 512566001154 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 512566001155 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 512566001156 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 512566001157 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 512566001158 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 512566001159 G1 box; other site 512566001160 putative GEF interaction site [polypeptide binding]; other site 512566001161 GTP/Mg2+ binding site [chemical binding]; other site 512566001162 Switch I region; other site 512566001163 G2 box; other site 512566001164 G3 box; other site 512566001165 Switch II region; other site 512566001166 G4 box; other site 512566001167 G5 box; other site 512566001168 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 512566001169 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 512566001170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 512566001171 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 512566001172 DAK2 domain; Region: Dak2; pfam02734 512566001173 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 512566001174 Transposase; Region: DDE_Tnp_ISL3; pfam01610 512566001175 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 512566001176 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 512566001177 PYR/PP interface [polypeptide binding]; other site 512566001178 dimer interface [polypeptide binding]; other site 512566001179 TPP binding site [chemical binding]; other site 512566001180 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 512566001181 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 512566001182 TPP-binding site [chemical binding]; other site 512566001183 dimer interface [polypeptide binding]; other site 512566001184 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 512566001185 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 512566001186 putative valine binding site [chemical binding]; other site 512566001187 dimer interface [polypeptide binding]; other site 512566001188 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 512566001189 ketol-acid reductoisomerase; Provisional; Region: PRK05479 512566001190 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 512566001191 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 512566001192 threonine dehydratase; Validated; Region: PRK08639 512566001193 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 512566001194 tetramer interface [polypeptide binding]; other site 512566001195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512566001196 catalytic residue [active] 512566001197 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 512566001198 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 512566001199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566001200 Walker A/P-loop; other site 512566001201 ATP binding site [chemical binding]; other site 512566001202 Q-loop/lid; other site 512566001203 ABC transporter signature motif; other site 512566001204 Walker B; other site 512566001205 D-loop; other site 512566001206 H-loop/switch region; other site 512566001207 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512566001208 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 512566001209 substrate binding pocket [chemical binding]; other site 512566001210 membrane-bound complex binding site; other site 512566001211 hinge residues; other site 512566001212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566001213 dimer interface [polypeptide binding]; other site 512566001214 conserved gate region; other site 512566001215 putative PBP binding loops; other site 512566001216 ABC-ATPase subunit interface; other site 512566001217 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 512566001218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 512566001219 Transposase; Region: DEDD_Tnp_IS110; pfam01548 512566001220 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 512566001221 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 512566001222 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 512566001223 active site 512566001224 DNA polymerase IV; Validated; Region: PRK02406 512566001225 DNA binding site [nucleotide binding] 512566001226 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 512566001227 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 512566001228 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512566001229 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 512566001230 non-specific DNA interactions [nucleotide binding]; other site 512566001231 DNA binding site [nucleotide binding] 512566001232 sequence specific DNA binding site [nucleotide binding]; other site 512566001233 putative cAMP binding site [chemical binding]; other site 512566001234 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512566001235 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512566001236 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 512566001237 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 512566001238 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 512566001239 methionine cluster; other site 512566001240 active site 512566001241 phosphorylation site [posttranslational modification] 512566001242 metal binding site [ion binding]; metal-binding site 512566001243 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 512566001244 beta-galactosidase; Region: BGL; TIGR03356 512566001245 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 512566001246 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 512566001247 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 512566001248 active site 512566001249 P-loop; other site 512566001250 phosphorylation site [posttranslational modification] 512566001251 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 512566001252 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 512566001253 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 512566001254 TrkA-N domain; Region: TrkA_N; pfam02254 512566001255 TrkA-C domain; Region: TrkA_C; pfam02080 512566001256 TrkA-N domain; Region: TrkA_N; pfam02254 512566001257 TrkA-C domain; Region: TrkA_C; pfam02080 512566001258 Uncharacterized conserved protein [Function unknown]; Region: COG1912 512566001259 hypothetical protein; Provisional; Region: PRK13661 512566001260 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 512566001261 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 512566001262 Walker A/P-loop; other site 512566001263 ATP binding site [chemical binding]; other site 512566001264 Q-loop/lid; other site 512566001265 ABC transporter signature motif; other site 512566001266 Walker B; other site 512566001267 D-loop; other site 512566001268 H-loop/switch region; other site 512566001269 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 512566001270 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 512566001271 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 512566001272 Walker A/P-loop; other site 512566001273 ATP binding site [chemical binding]; other site 512566001274 Q-loop/lid; other site 512566001275 ABC transporter signature motif; other site 512566001276 Walker B; other site 512566001277 D-loop; other site 512566001278 H-loop/switch region; other site 512566001279 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 512566001280 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 512566001281 Predicted membrane protein [Function unknown]; Region: COG3601 512566001282 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 512566001283 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 512566001284 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 512566001285 active site 512566001286 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512566001287 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512566001288 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 512566001289 CTP synthetase; Validated; Region: pyrG; PRK05380 512566001290 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 512566001291 Catalytic site [active] 512566001292 active site 512566001293 UTP binding site [chemical binding]; other site 512566001294 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 512566001295 active site 512566001296 putative oxyanion hole; other site 512566001297 catalytic triad [active] 512566001298 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 512566001299 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 512566001300 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 512566001301 PhoU domain; Region: PhoU; pfam01895 512566001302 PhoU domain; Region: PhoU; pfam01895 512566001303 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 512566001304 Glycosyl hydrolase family 85; Region: Glyco_hydro_85; pfam03644 512566001305 active site 512566001306 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 512566001307 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 512566001308 G5 domain; Region: G5; pfam07501 512566001309 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 512566001310 Phosphoglycerate kinase; Region: PGK; pfam00162 512566001311 substrate binding site [chemical binding]; other site 512566001312 hinge regions; other site 512566001313 ADP binding site [chemical binding]; other site 512566001314 catalytic site [active] 512566001315 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 512566001316 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 512566001317 Predicted membrane protein [Function unknown]; Region: COG4129 512566001318 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 512566001319 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 512566001320 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512566001321 DNA binding residues [nucleotide binding] 512566001322 putative dimer interface [polypeptide binding]; other site 512566001323 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 512566001324 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 512566001325 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 512566001326 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 512566001327 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 512566001328 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 512566001329 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 512566001330 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 512566001331 HsdM N-terminal domain; Region: HsdM_N; pfam12161 512566001332 Methyltransferase domain; Region: Methyltransf_26; pfam13659 512566001333 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 512566001334 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 512566001335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512566001336 ATP binding site [chemical binding]; other site 512566001337 putative Mg++ binding site [ion binding]; other site 512566001338 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 512566001339 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 512566001340 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 512566001341 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 512566001342 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 512566001343 dimer interface [polypeptide binding]; other site 512566001344 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 512566001345 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 512566001346 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 512566001347 nucleotide binding site [chemical binding]; other site 512566001348 NEF interaction site [polypeptide binding]; other site 512566001349 SBD interface [polypeptide binding]; other site 512566001350 chaperone protein DnaJ; Provisional; Region: PRK14276 512566001351 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 512566001352 HSP70 interaction site [polypeptide binding]; other site 512566001353 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 512566001354 substrate binding site [polypeptide binding]; other site 512566001355 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 512566001356 Zn binding sites [ion binding]; other site 512566001357 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 512566001358 substrate binding site [polypeptide binding]; other site 512566001359 dimer interface [polypeptide binding]; other site 512566001360 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 512566001361 HIT family signature motif; other site 512566001362 catalytic residue [active] 512566001363 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 512566001364 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512566001365 Walker A/P-loop; other site 512566001366 ATP binding site [chemical binding]; other site 512566001367 Q-loop/lid; other site 512566001368 ABC transporter signature motif; other site 512566001369 Walker B; other site 512566001370 D-loop; other site 512566001371 H-loop/switch region; other site 512566001372 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 512566001373 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 512566001374 LytTr DNA-binding domain; Region: LytTR; pfam04397 512566001375 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 512566001376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512566001377 active site 512566001378 phosphorylation site [posttranslational modification] 512566001379 intermolecular recognition site; other site 512566001380 dimerization interface [polypeptide binding]; other site 512566001381 LytTr DNA-binding domain; Region: LytTR; pfam04397 512566001382 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 512566001383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566001384 ATP binding site [chemical binding]; other site 512566001385 Mg2+ binding site [ion binding]; other site 512566001386 G-X-G motif; other site 512566001387 COMC family; Region: ComC; pfam03047 512566001388 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 512566001389 HlyD family secretion protein; Region: HlyD_3; pfam13437 512566001390 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 512566001391 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 512566001392 putative active site [active] 512566001393 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512566001394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566001395 Walker A/P-loop; other site 512566001396 ATP binding site [chemical binding]; other site 512566001397 Q-loop/lid; other site 512566001398 ABC transporter signature motif; other site 512566001399 Walker B; other site 512566001400 D-loop; other site 512566001401 H-loop/switch region; other site 512566001402 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 512566001403 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 512566001404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 512566001405 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 512566001406 CAAX protease self-immunity; Region: Abi; pfam02517 512566001407 CAAX protease self-immunity; Region: Abi; pfam02517 512566001408 Phosphotransferase enzyme family; Region: APH; pfam01636 512566001409 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 512566001410 substrate binding site [chemical binding]; other site 512566001411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566001412 S-adenosylmethionine binding site [chemical binding]; other site 512566001413 ribosome maturation protein RimP; Reviewed; Region: PRK00092 512566001414 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 512566001415 putative oligomer interface [polypeptide binding]; other site 512566001416 putative RNA binding site [nucleotide binding]; other site 512566001417 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 512566001418 NusA N-terminal domain; Region: NusA_N; pfam08529 512566001419 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 512566001420 RNA binding site [nucleotide binding]; other site 512566001421 homodimer interface [polypeptide binding]; other site 512566001422 NusA-like KH domain; Region: KH_5; pfam13184 512566001423 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 512566001424 G-X-X-G motif; other site 512566001425 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 512566001426 putative RNA binding cleft [nucleotide binding]; other site 512566001427 hypothetical protein; Provisional; Region: PRK07283 512566001428 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 512566001429 translation initiation factor IF-2; Region: IF-2; TIGR00487 512566001430 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 512566001431 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 512566001432 G1 box; other site 512566001433 putative GEF interaction site [polypeptide binding]; other site 512566001434 GTP/Mg2+ binding site [chemical binding]; other site 512566001435 Switch I region; other site 512566001436 G2 box; other site 512566001437 G3 box; other site 512566001438 Switch II region; other site 512566001439 G4 box; other site 512566001440 G5 box; other site 512566001441 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 512566001442 Translation-initiation factor 2; Region: IF-2; pfam11987 512566001443 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 512566001444 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 512566001445 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 512566001446 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 512566001447 Uncharacterized conserved protein [Function unknown]; Region: COG2461 512566001448 Family of unknown function (DUF438); Region: DUF438; pfam04282 512566001449 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 512566001450 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 512566001451 putative active site [active] 512566001452 heme pocket [chemical binding]; other site 512566001453 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 512566001454 hypothetical protein; Provisional; Region: PRK07758 512566001455 Flavin Reductases; Region: FlaRed; cl00801 512566001456 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 512566001457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512566001458 AAA domain; Region: AAA_18; pfam13238 512566001459 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 512566001460 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512566001461 active site 512566001462 HIGH motif; other site 512566001463 nucleotide binding site [chemical binding]; other site 512566001464 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 512566001465 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 512566001466 active site 512566001467 KMSKS motif; other site 512566001468 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 512566001469 tRNA binding surface [nucleotide binding]; other site 512566001470 anticodon binding site; other site 512566001471 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 512566001472 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 512566001473 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 512566001474 Fic/DOC family; Region: Fic; pfam02661 512566001475 Integrase core domain; Region: rve; pfam00665 512566001476 Integrase core domain; Region: rve_2; pfam13333 512566001477 HTH-like domain; Region: HTH_21; pfam13276 512566001478 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 512566001479 Homeodomain-like domain; Region: HTH_23; cl17451 512566001480 transcriptional antiterminator BglG; Provisional; Region: PRK09772 512566001481 CAT RNA binding domain; Region: CAT_RBD; smart01061 512566001482 PRD domain; Region: PRD; pfam00874 512566001483 PRD domain; Region: PRD; pfam00874 512566001484 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 512566001485 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 512566001486 active site turn [active] 512566001487 phosphorylation site [posttranslational modification] 512566001488 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 512566001489 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 512566001490 HPr interaction site; other site 512566001491 glycerol kinase (GK) interaction site [polypeptide binding]; other site 512566001492 active site 512566001493 phosphorylation site [posttranslational modification] 512566001494 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 512566001495 beta-galactosidase; Region: BGL; TIGR03356 512566001496 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 512566001497 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 512566001498 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 512566001499 dimer interface [polypeptide binding]; other site 512566001500 motif 1; other site 512566001501 active site 512566001502 motif 2; other site 512566001503 motif 3; other site 512566001504 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 512566001505 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512566001506 Coenzyme A binding pocket [chemical binding]; other site 512566001507 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 512566001508 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 512566001509 putative tRNA-binding site [nucleotide binding]; other site 512566001510 B3/4 domain; Region: B3_4; pfam03483 512566001511 tRNA synthetase B5 domain; Region: B5; smart00874 512566001512 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 512566001513 dimer interface [polypeptide binding]; other site 512566001514 motif 1; other site 512566001515 motif 3; other site 512566001516 motif 2; other site 512566001517 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 512566001518 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512566001519 putative catalytic site [active] 512566001520 putative metal binding site [ion binding]; other site 512566001521 putative phosphate binding site [ion binding]; other site 512566001522 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 512566001523 Helix-turn-helix domain; Region: HTH_38; pfam13936 512566001524 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 512566001525 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566001526 non-specific DNA binding site [nucleotide binding]; other site 512566001527 salt bridge; other site 512566001528 sequence-specific DNA binding site [nucleotide binding]; other site 512566001529 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 512566001530 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 512566001531 THF binding site; other site 512566001532 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 512566001533 substrate binding site [chemical binding]; other site 512566001534 THF binding site; other site 512566001535 zinc-binding site [ion binding]; other site 512566001536 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 512566001537 FAD binding site [chemical binding]; other site 512566001538 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 512566001539 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 512566001540 RNase E interface [polypeptide binding]; other site 512566001541 trimer interface [polypeptide binding]; other site 512566001542 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 512566001543 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 512566001544 RNase E interface [polypeptide binding]; other site 512566001545 trimer interface [polypeptide binding]; other site 512566001546 active site 512566001547 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 512566001548 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 512566001549 RNA binding site [nucleotide binding]; other site 512566001550 domain interface; other site 512566001551 serine O-acetyltransferase; Region: cysE; TIGR01172 512566001552 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 512566001553 trimer interface [polypeptide binding]; other site 512566001554 active site 512566001555 substrate binding site [chemical binding]; other site 512566001556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512566001557 Coenzyme A binding pocket [chemical binding]; other site 512566001558 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512566001559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512566001560 Coenzyme A binding pocket [chemical binding]; other site 512566001561 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 512566001562 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 512566001563 active site 512566001564 HIGH motif; other site 512566001565 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 512566001566 KMSKS motif; other site 512566001567 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 512566001568 tRNA binding surface [nucleotide binding]; other site 512566001569 anticodon binding site; other site 512566001570 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 512566001571 active site 512566001572 metal binding site [ion binding]; metal-binding site 512566001573 dimerization interface [polypeptide binding]; other site 512566001574 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 512566001575 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 512566001576 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 512566001577 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512566001578 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 512566001579 FtsX-like permease family; Region: FtsX; pfam02687 512566001580 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512566001581 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512566001582 Walker A/P-loop; other site 512566001583 ATP binding site [chemical binding]; other site 512566001584 Q-loop/lid; other site 512566001585 ABC transporter signature motif; other site 512566001586 Walker B; other site 512566001587 D-loop; other site 512566001588 H-loop/switch region; other site 512566001589 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 512566001590 FtsX-like permease family; Region: FtsX; pfam02687 512566001591 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512566001592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512566001593 active site 512566001594 phosphorylation site [posttranslational modification] 512566001595 intermolecular recognition site; other site 512566001596 dimerization interface [polypeptide binding]; other site 512566001597 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512566001598 DNA binding site [nucleotide binding] 512566001599 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512566001600 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512566001601 dimerization interface [polypeptide binding]; other site 512566001602 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512566001603 dimer interface [polypeptide binding]; other site 512566001604 phosphorylation site [posttranslational modification] 512566001605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566001606 ATP binding site [chemical binding]; other site 512566001607 Mg2+ binding site [ion binding]; other site 512566001608 G-X-G motif; other site 512566001609 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 512566001610 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 512566001611 intersubunit interface [polypeptide binding]; other site 512566001612 active site 512566001613 zinc binding site [ion binding]; other site 512566001614 Na+ binding site [ion binding]; other site 512566001615 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 512566001616 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 512566001617 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 512566001618 FAD binding pocket [chemical binding]; other site 512566001619 FAD binding motif [chemical binding]; other site 512566001620 phosphate binding motif [ion binding]; other site 512566001621 beta-alpha-beta structure motif; other site 512566001622 NAD binding pocket [chemical binding]; other site 512566001623 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566001624 dimer interface [polypeptide binding]; other site 512566001625 conserved gate region; other site 512566001626 putative PBP binding loops; other site 512566001627 ABC-ATPase subunit interface; other site 512566001628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566001629 dimer interface [polypeptide binding]; other site 512566001630 conserved gate region; other site 512566001631 putative PBP binding loops; other site 512566001632 ABC-ATPase subunit interface; other site 512566001633 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 512566001634 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512566001635 substrate binding pocket [chemical binding]; other site 512566001636 membrane-bound complex binding site; other site 512566001637 hinge residues; other site 512566001638 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 512566001639 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 512566001640 Walker A/P-loop; other site 512566001641 ATP binding site [chemical binding]; other site 512566001642 Q-loop/lid; other site 512566001643 ABC transporter signature motif; other site 512566001644 Walker B; other site 512566001645 D-loop; other site 512566001646 H-loop/switch region; other site 512566001647 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 512566001648 DHH family; Region: DHH; pfam01368 512566001649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 512566001650 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 512566001651 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 512566001652 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 512566001653 Predicted esterase [General function prediction only]; Region: COG0627 512566001654 S-formylglutathione hydrolase; Region: PLN02442 512566001655 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 512566001656 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 512566001657 FemAB family; Region: FemAB; pfam02388 512566001658 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 512566001659 active site 512566001660 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 512566001661 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 512566001662 GIY-YIG motif/motif A; other site 512566001663 active site 512566001664 catalytic site [active] 512566001665 putative DNA binding site [nucleotide binding]; other site 512566001666 metal binding site [ion binding]; metal-binding site 512566001667 UvrB/uvrC motif; Region: UVR; pfam02151 512566001668 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 512566001669 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 512566001670 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 512566001671 active site 512566001672 metal binding site [ion binding]; metal-binding site 512566001673 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 512566001674 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512566001675 substrate binding pocket [chemical binding]; other site 512566001676 membrane-bound complex binding site; other site 512566001677 hinge residues; other site 512566001678 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 512566001679 FMN binding site [chemical binding]; other site 512566001680 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 512566001681 dimer interface [polypeptide binding]; other site 512566001682 dipeptidase PepV; Reviewed; Region: PRK07318 512566001683 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 512566001684 active site 512566001685 metal binding site [ion binding]; metal-binding site 512566001686 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 512566001687 putative uracil binding site [chemical binding]; other site 512566001688 putative active site [active] 512566001689 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 512566001690 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 512566001691 active site residue [active] 512566001692 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 512566001693 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 512566001694 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 512566001695 putative oligomer interface [polypeptide binding]; other site 512566001696 putative active site [active] 512566001697 metal binding site [ion binding]; metal-binding site 512566001698 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 512566001699 nucleotide binding site/active site [active] 512566001700 HIT family signature motif; other site 512566001701 catalytic residue [active] 512566001702 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 512566001703 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 512566001704 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 512566001705 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 512566001706 23S rRNA interface [nucleotide binding]; other site 512566001707 L7/L12 interface [polypeptide binding]; other site 512566001708 putative thiostrepton binding site; other site 512566001709 L25 interface [polypeptide binding]; other site 512566001710 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 512566001711 mRNA/rRNA interface [nucleotide binding]; other site 512566001712 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 512566001713 Transposase; Region: DDE_Tnp_ISL3; pfam01610 512566001714 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 512566001715 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 512566001716 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 512566001717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566001718 Walker A/P-loop; other site 512566001719 ATP binding site [chemical binding]; other site 512566001720 Q-loop/lid; other site 512566001721 ABC transporter signature motif; other site 512566001722 Walker B; other site 512566001723 D-loop; other site 512566001724 H-loop/switch region; other site 512566001725 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 512566001726 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 512566001727 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 512566001728 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 512566001729 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 512566001730 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 512566001731 putative active site [active] 512566001732 catalytic triad [active] 512566001733 PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819 512566001734 PA/protease or protease-like domain interface [polypeptide binding]; other site 512566001735 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 512566001736 catalytic residues [active] 512566001737 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 512566001738 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 512566001739 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 512566001740 active site 512566001741 phosphorylation site [posttranslational modification] 512566001742 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 512566001743 active site 512566001744 P-loop; other site 512566001745 phosphorylation site [posttranslational modification] 512566001746 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 512566001747 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 512566001748 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 512566001749 F0F1 ATP synthase subunit B; Validated; Region: PRK08475 512566001750 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 512566001751 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 512566001752 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 512566001753 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 512566001754 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 512566001755 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 512566001756 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 512566001757 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 512566001758 G5 domain; Region: G5; pfam07501 512566001759 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 512566001760 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 512566001761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 512566001762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 512566001763 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 512566001764 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 512566001765 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 512566001766 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 512566001767 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 512566001768 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 512566001769 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 512566001770 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 512566001771 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 512566001772 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 512566001773 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 512566001774 catalytic residues [active] 512566001775 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 512566001776 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 512566001777 SelR domain; Region: SelR; pfam01641 512566001778 Response regulator receiver domain; Region: Response_reg; pfam00072 512566001779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512566001780 active site 512566001781 phosphorylation site [posttranslational modification] 512566001782 intermolecular recognition site; other site 512566001783 dimerization interface [polypeptide binding]; other site 512566001784 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512566001785 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512566001786 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 512566001787 Cache domain; Region: Cache_1; pfam02743 512566001788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 512566001789 dimerization interface [polypeptide binding]; other site 512566001790 Histidine kinase; Region: His_kinase; pfam06580 512566001791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566001792 ATP binding site [chemical binding]; other site 512566001793 Mg2+ binding site [ion binding]; other site 512566001794 G-X-G motif; other site 512566001795 hypothetical protein; Provisional; Region: PRK13690 512566001796 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 512566001797 G5 domain; Region: G5; pfam07501 512566001798 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 512566001799 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 512566001800 aminodeoxychorismate synthase; Provisional; Region: PRK07508 512566001801 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 512566001802 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 512566001803 substrate-cofactor binding pocket; other site 512566001804 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 512566001805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512566001806 catalytic residue [active] 512566001807 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512566001808 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 512566001809 Excalibur calcium-binding domain; Region: Excalibur; smart00894 512566001810 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 512566001811 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512566001812 nucleotide binding site [chemical binding]; other site 512566001813 thymidylate synthase; Reviewed; Region: thyA; PRK01827 512566001814 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 512566001815 dimerization interface [polypeptide binding]; other site 512566001816 active site 512566001817 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 512566001818 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 512566001819 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 512566001820 GTPases [General function prediction only]; Region: HflX; COG2262 512566001821 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 512566001822 HflX GTPase family; Region: HflX; cd01878 512566001823 G1 box; other site 512566001824 GTP/Mg2+ binding site [chemical binding]; other site 512566001825 Switch I region; other site 512566001826 G2 box; other site 512566001827 G3 box; other site 512566001828 Switch II region; other site 512566001829 G4 box; other site 512566001830 G5 box; other site 512566001831 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 512566001832 ribonuclease Z; Region: RNase_Z; TIGR02651 512566001833 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 512566001834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512566001835 NAD(P) binding site [chemical binding]; other site 512566001836 active site 512566001837 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512566001838 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512566001839 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 512566001840 dimerization interface [polypeptide binding]; other site 512566001841 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 512566001842 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 512566001843 active site residue [active] 512566001844 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 512566001845 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 512566001846 RNA binding surface [nucleotide binding]; other site 512566001847 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 512566001848 active site 512566001849 uracil binding [chemical binding]; other site 512566001850 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 512566001851 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 512566001852 G1 box; other site 512566001853 putative GEF interaction site [polypeptide binding]; other site 512566001854 GTP/Mg2+ binding site [chemical binding]; other site 512566001855 Switch I region; other site 512566001856 G2 box; other site 512566001857 G3 box; other site 512566001858 Switch II region; other site 512566001859 G4 box; other site 512566001860 G5 box; other site 512566001861 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 512566001862 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 512566001863 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 512566001864 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 512566001865 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 512566001866 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 512566001867 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 512566001868 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 512566001869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566001870 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 512566001871 Walker A/P-loop; other site 512566001872 ATP binding site [chemical binding]; other site 512566001873 Q-loop/lid; other site 512566001874 ABC transporter signature motif; other site 512566001875 Walker B; other site 512566001876 D-loop; other site 512566001877 H-loop/switch region; other site 512566001878 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 512566001879 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 512566001880 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 512566001881 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 512566001882 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 512566001883 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 512566001884 homodimer interface [polypeptide binding]; other site 512566001885 active site 512566001886 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 512566001887 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 512566001888 Cell division protein FtsQ; Region: FtsQ; pfam03799 512566001889 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 512566001890 active site 512566001891 dimer interface [polypeptide binding]; other site 512566001892 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512566001893 active site 512566001894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566001895 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 512566001896 Walker A/P-loop; other site 512566001897 ATP binding site [chemical binding]; other site 512566001898 Q-loop/lid; other site 512566001899 ABC transporter signature motif; other site 512566001900 Walker B; other site 512566001901 D-loop; other site 512566001902 H-loop/switch region; other site 512566001903 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512566001904 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 512566001905 substrate binding pocket [chemical binding]; other site 512566001906 membrane-bound complex binding site; other site 512566001907 hinge residues; other site 512566001908 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 512566001909 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 512566001910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566001911 ABC transporter signature motif; other site 512566001912 Walker B; other site 512566001913 D-loop; other site 512566001914 H-loop/switch region; other site 512566001915 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 512566001916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566001917 Walker A/P-loop; other site 512566001918 ATP binding site [chemical binding]; other site 512566001919 Q-loop/lid; other site 512566001920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512566001921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566001922 dimer interface [polypeptide binding]; other site 512566001923 conserved gate region; other site 512566001924 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 512566001925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566001926 dimer interface [polypeptide binding]; other site 512566001927 conserved gate region; other site 512566001928 putative PBP binding loops; other site 512566001929 ABC-ATPase subunit interface; other site 512566001930 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 512566001931 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 512566001932 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 512566001933 dimer interface [polypeptide binding]; other site 512566001934 putative anticodon binding site; other site 512566001935 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 512566001936 motif 1; other site 512566001937 active site 512566001938 motif 2; other site 512566001939 motif 3; other site 512566001940 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 512566001941 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 512566001942 teramer interface [polypeptide binding]; other site 512566001943 active site 512566001944 FMN binding site [chemical binding]; other site 512566001945 catalytic residues [active] 512566001946 Putative transcription activator [Transcription]; Region: TenA; COG0819 512566001947 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 512566001948 substrate binding site [chemical binding]; other site 512566001949 multimerization interface [polypeptide binding]; other site 512566001950 ATP binding site [chemical binding]; other site 512566001951 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 512566001952 thiamine phosphate binding site [chemical binding]; other site 512566001953 active site 512566001954 pyrophosphate binding site [ion binding]; other site 512566001955 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 512566001956 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 512566001957 Walker A/P-loop; other site 512566001958 ATP binding site [chemical binding]; other site 512566001959 ABC transporter; Region: ABC_tran; pfam00005 512566001960 Q-loop/lid; other site 512566001961 ABC transporter signature motif; other site 512566001962 Walker B; other site 512566001963 D-loop; other site 512566001964 H-loop/switch region; other site 512566001965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566001966 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 512566001967 Walker A/P-loop; other site 512566001968 ATP binding site [chemical binding]; other site 512566001969 Q-loop/lid; other site 512566001970 ABC transporter signature motif; other site 512566001971 Walker B; other site 512566001972 D-loop; other site 512566001973 H-loop/switch region; other site 512566001974 Putative transcription activator [Transcription]; Region: TenA; COG0819 512566001975 Predicted membrane protein [Function unknown]; Region: COG4732 512566001976 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 512566001977 substrate binding site [chemical binding]; other site 512566001978 multimerization interface [polypeptide binding]; other site 512566001979 ATP binding site [chemical binding]; other site 512566001980 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 512566001981 thiamine phosphate binding site [chemical binding]; other site 512566001982 active site 512566001983 pyrophosphate binding site [ion binding]; other site 512566001984 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 512566001985 dimer interface [polypeptide binding]; other site 512566001986 substrate binding site [chemical binding]; other site 512566001987 ATP binding site [chemical binding]; other site 512566001988 Predicted transcriptional regulator [Transcription]; Region: COG3682 512566001989 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 512566001990 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 512566001991 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 512566001992 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 512566001993 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 512566001994 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 512566001995 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 512566001996 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 512566001997 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 512566001998 PYR/PP interface [polypeptide binding]; other site 512566001999 dimer interface [polypeptide binding]; other site 512566002000 tetramer interface [polypeptide binding]; other site 512566002001 TPP binding site [chemical binding]; other site 512566002002 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 512566002003 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 512566002004 TPP-binding site [chemical binding]; other site 512566002005 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512566002006 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 512566002007 active site 512566002008 DDE superfamily endonuclease; Region: DDE_3; pfam13358 512566002009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 512566002010 Winged helix-turn helix; Region: HTH_33; pfam13592 512566002011 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 512566002012 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 512566002013 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 512566002014 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 512566002015 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 512566002016 Na2 binding site [ion binding]; other site 512566002017 putative substrate binding site 1 [chemical binding]; other site 512566002018 Na binding site 1 [ion binding]; other site 512566002019 putative substrate binding site 2 [chemical binding]; other site 512566002020 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 512566002021 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512566002022 DNA binding residues [nucleotide binding] 512566002023 dimer interface [polypeptide binding]; other site 512566002024 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 512566002025 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 512566002026 putative active site [active] 512566002027 nucleotide binding site [chemical binding]; other site 512566002028 nudix motif; other site 512566002029 putative metal binding site [ion binding]; other site 512566002030 HI0933-like protein; Region: HI0933_like; pfam03486 512566002031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 512566002032 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 512566002033 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512566002034 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512566002035 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 512566002036 catalytic motif [active] 512566002037 Zn binding site [ion binding]; other site 512566002038 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512566002039 active site 512566002040 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 512566002041 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 512566002042 oligomer interface [polypeptide binding]; other site 512566002043 active site residues [active] 512566002044 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 512566002045 hypothetical protein; Provisional; Region: PRK02302 512566002046 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 512566002047 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 512566002048 putative ligand binding site [chemical binding]; other site 512566002049 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512566002050 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 512566002051 TM-ABC transporter signature motif; other site 512566002052 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 512566002053 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 512566002054 TM-ABC transporter signature motif; other site 512566002055 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 512566002056 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 512566002057 Walker A/P-loop; other site 512566002058 ATP binding site [chemical binding]; other site 512566002059 Q-loop/lid; other site 512566002060 ABC transporter signature motif; other site 512566002061 Walker B; other site 512566002062 D-loop; other site 512566002063 H-loop/switch region; other site 512566002064 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 512566002065 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 512566002066 Walker A/P-loop; other site 512566002067 ATP binding site [chemical binding]; other site 512566002068 Q-loop/lid; other site 512566002069 ABC transporter signature motif; other site 512566002070 Walker B; other site 512566002071 D-loop; other site 512566002072 H-loop/switch region; other site 512566002073 FOG: CBS domain [General function prediction only]; Region: COG0517 512566002074 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 512566002075 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 512566002076 peptide chain release factor 2; Region: prfB; TIGR00020 512566002077 PCRF domain; Region: PCRF; pfam03462 512566002078 RF-1 domain; Region: RF-1; pfam00472 512566002079 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 512566002080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566002081 Walker A/P-loop; other site 512566002082 ATP binding site [chemical binding]; other site 512566002083 Q-loop/lid; other site 512566002084 ABC transporter signature motif; other site 512566002085 Walker B; other site 512566002086 D-loop; other site 512566002087 H-loop/switch region; other site 512566002088 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 512566002089 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 512566002090 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 512566002091 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 512566002092 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 512566002093 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 512566002094 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 512566002095 active site turn [active] 512566002096 phosphorylation site [posttranslational modification] 512566002097 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 512566002098 HPr interaction site; other site 512566002099 glycerol kinase (GK) interaction site [polypeptide binding]; other site 512566002100 active site 512566002101 phosphorylation site [posttranslational modification] 512566002102 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512566002103 putative metal binding site [ion binding]; other site 512566002104 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512566002105 putative catalytic site [active] 512566002106 putative phosphate binding site [ion binding]; other site 512566002107 putative metal binding site [ion binding]; other site 512566002108 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 512566002109 DEAD-like helicases superfamily; Region: DEXDc; smart00487 512566002110 ATP binding site [chemical binding]; other site 512566002111 Mg++ binding site [ion binding]; other site 512566002112 motif III; other site 512566002113 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512566002114 nucleotide binding region [chemical binding]; other site 512566002115 ATP-binding site [chemical binding]; other site 512566002116 S-adenosylmethionine synthetase; Validated; Region: PRK05250 512566002117 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 512566002118 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 512566002119 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 512566002120 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 512566002121 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 512566002122 active site 512566002123 FMN binding site [chemical binding]; other site 512566002124 substrate binding site [chemical binding]; other site 512566002125 catalytic residues [active] 512566002126 homodimer interface [polypeptide binding]; other site 512566002127 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 512566002128 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 512566002129 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 512566002130 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 512566002131 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 512566002132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 512566002133 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 512566002134 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512566002135 FeS/SAM binding site; other site 512566002136 VanZ like family; Region: VanZ; pfam04892 512566002137 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 512566002138 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512566002139 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512566002140 ABC transporter; Region: ABC_tran_2; pfam12848 512566002141 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512566002142 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 512566002143 active site 512566002144 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 512566002145 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 512566002146 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 512566002147 KH domain; Region: KH_4; pfam13083 512566002148 G-X-X-G motif; other site 512566002149 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 512566002150 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 512566002151 RimM N-terminal domain; Region: RimM; pfam01782 512566002152 PRC-barrel domain; Region: PRC; pfam05239 512566002153 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 512566002154 ATP cone domain; Region: ATP-cone; pfam03477 512566002155 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 512566002156 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 512566002157 glutathione reductase; Validated; Region: PRK06116 512566002158 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512566002159 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512566002160 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 512566002161 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 512566002162 HlyD family secretion protein; Region: HlyD_3; pfam13437 512566002163 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512566002164 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512566002165 Walker A/P-loop; other site 512566002166 ATP binding site [chemical binding]; other site 512566002167 Q-loop/lid; other site 512566002168 ABC transporter signature motif; other site 512566002169 Walker B; other site 512566002170 D-loop; other site 512566002171 H-loop/switch region; other site 512566002172 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512566002173 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 512566002174 FtsX-like permease family; Region: FtsX; pfam02687 512566002175 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 512566002176 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 512566002177 active site 512566002178 HIGH motif; other site 512566002179 KMSKS motif; other site 512566002180 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 512566002181 tRNA binding surface [nucleotide binding]; other site 512566002182 anticodon binding site; other site 512566002183 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 512566002184 dimer interface [polypeptide binding]; other site 512566002185 putative tRNA-binding site [nucleotide binding]; other site 512566002186 Predicted transcriptional regulators [Transcription]; Region: COG1695 512566002187 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 512566002188 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512566002189 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512566002190 active site 512566002191 catalytic tetrad [active] 512566002192 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 512566002193 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 512566002194 classical (c) SDRs; Region: SDR_c; cd05233 512566002195 NAD(P) binding site [chemical binding]; other site 512566002196 active site 512566002197 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 512566002198 nudix motif; other site 512566002199 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 512566002200 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 512566002201 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 512566002202 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 512566002203 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 512566002204 Zn binding site [ion binding]; other site 512566002205 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512566002206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512566002207 active site 512566002208 phosphorylation site [posttranslational modification] 512566002209 intermolecular recognition site; other site 512566002210 dimerization interface [polypeptide binding]; other site 512566002211 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512566002212 DNA binding site [nucleotide binding] 512566002213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512566002214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512566002215 dimer interface [polypeptide binding]; other site 512566002216 phosphorylation site [posttranslational modification] 512566002217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566002218 ATP binding site [chemical binding]; other site 512566002219 Mg2+ binding site [ion binding]; other site 512566002220 G-X-G motif; other site 512566002221 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 512566002222 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 512566002223 Peptidase family U32; Region: Peptidase_U32; pfam01136 512566002224 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 512566002225 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 512566002226 active site 512566002227 catalytic site [active] 512566002228 substrate binding site [chemical binding]; other site 512566002229 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512566002230 ATP binding site [chemical binding]; other site 512566002231 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 512566002232 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 512566002233 DJ-1 family protein; Region: not_thiJ; TIGR01383 512566002234 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 512566002235 conserved cys residue [active] 512566002236 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 512566002237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566002238 motif II; other site 512566002239 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 512566002240 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566002241 Mg2+ binding site [ion binding]; other site 512566002242 G-X-G motif; other site 512566002243 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 512566002244 anchoring element; other site 512566002245 dimer interface [polypeptide binding]; other site 512566002246 ATP binding site [chemical binding]; other site 512566002247 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 512566002248 active site 512566002249 putative metal-binding site [ion binding]; other site 512566002250 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 512566002251 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 512566002252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 512566002253 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 512566002254 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 512566002255 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 512566002256 Transposase; Region: HTH_Tnp_IS630; pfam01710 512566002257 Helix-turn-helix domain; Region: HTH_28; pfam13518 512566002258 DDE superfamily endonuclease; Region: DDE_3; pfam13358 512566002259 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 512566002260 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512566002261 Walker A motif; other site 512566002262 ATP binding site [chemical binding]; other site 512566002263 Walker B motif; other site 512566002264 arginine finger; other site 512566002265 UvrB/uvrC motif; Region: UVR; pfam02151 512566002266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512566002267 Walker A motif; other site 512566002268 ATP binding site [chemical binding]; other site 512566002269 Walker B motif; other site 512566002270 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 512566002271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 512566002272 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 512566002273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566002274 dimer interface [polypeptide binding]; other site 512566002275 conserved gate region; other site 512566002276 putative PBP binding loops; other site 512566002277 ABC-ATPase subunit interface; other site 512566002278 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 512566002279 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 512566002280 Walker A/P-loop; other site 512566002281 ATP binding site [chemical binding]; other site 512566002282 Q-loop/lid; other site 512566002283 ABC transporter signature motif; other site 512566002284 Walker B; other site 512566002285 D-loop; other site 512566002286 H-loop/switch region; other site 512566002287 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 512566002288 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 512566002289 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 512566002290 homodimer interface [polypeptide binding]; other site 512566002291 NADP binding site [chemical binding]; other site 512566002292 substrate binding site [chemical binding]; other site 512566002293 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 512566002294 putative substrate binding site [chemical binding]; other site 512566002295 putative ATP binding site [chemical binding]; other site 512566002296 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 512566002297 tetramer (dimer of dimers) interface [polypeptide binding]; other site 512566002298 active site 512566002299 dimer interface [polypeptide binding]; other site 512566002300 phosphopentomutase; Provisional; Region: PRK05362 512566002301 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 512566002302 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 512566002303 purine nucleoside phosphorylase; Provisional; Region: PRK08202 512566002304 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 512566002305 nucleophilic elbow; other site 512566002306 catalytic triad; other site 512566002307 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 512566002308 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 512566002309 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 512566002310 topology modulation protein; Provisional; Region: PRK07261 512566002311 AAA domain; Region: AAA_17; pfam13207 512566002312 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 512566002313 pantothenate kinase; Provisional; Region: PRK05439 512566002314 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 512566002315 ATP-binding site [chemical binding]; other site 512566002316 CoA-binding site [chemical binding]; other site 512566002317 Mg2+-binding site [ion binding]; other site 512566002318 Methyltransferase domain; Region: Methyltransf_31; pfam13847 512566002319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566002320 S-adenosylmethionine binding site [chemical binding]; other site 512566002321 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 512566002322 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 512566002323 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 512566002324 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 512566002325 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 512566002326 intersubunit interface [polypeptide binding]; other site 512566002327 active site 512566002328 catalytic residue [active] 512566002329 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 512566002330 active site 512566002331 catalytic motif [active] 512566002332 Zn binding site [ion binding]; other site 512566002333 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 512566002334 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 512566002335 ligand binding site [chemical binding]; other site 512566002336 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 512566002337 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 512566002338 Walker A/P-loop; other site 512566002339 ATP binding site [chemical binding]; other site 512566002340 Q-loop/lid; other site 512566002341 ABC transporter signature motif; other site 512566002342 Walker B; other site 512566002343 D-loop; other site 512566002344 H-loop/switch region; other site 512566002345 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 512566002346 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512566002347 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 512566002348 TM-ABC transporter signature motif; other site 512566002349 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512566002350 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 512566002351 TM-ABC transporter signature motif; other site 512566002352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 512566002353 Helix-turn-helix domain; Region: HTH_28; pfam13518 512566002354 HTH-like domain; Region: HTH_21; pfam13276 512566002355 Integrase core domain; Region: rve; pfam00665 512566002356 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 512566002357 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 512566002358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566002359 Mg2+ binding site [ion binding]; other site 512566002360 G-X-G motif; other site 512566002361 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 512566002362 anchoring element; other site 512566002363 dimer interface [polypeptide binding]; other site 512566002364 ATP binding site [chemical binding]; other site 512566002365 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 512566002366 active site 512566002367 putative metal-binding site [ion binding]; other site 512566002368 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 512566002369 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 512566002370 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 512566002371 CAP-like domain; other site 512566002372 active site 512566002373 primary dimer interface [polypeptide binding]; other site 512566002374 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512566002375 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 512566002376 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 512566002377 homodimer interface [polypeptide binding]; other site 512566002378 substrate-cofactor binding pocket; other site 512566002379 catalytic residue [active] 512566002380 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 512566002381 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 512566002382 Predicted membrane protein [Function unknown]; Region: COG3819 512566002383 Predicted membrane protein [Function unknown]; Region: COG3817 512566002384 Protein of unknown function (DUF979); Region: DUF979; pfam06166 512566002385 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 512566002386 putative substrate binding pocket [chemical binding]; other site 512566002387 AC domain interface; other site 512566002388 catalytic triad [active] 512566002389 AB domain interface; other site 512566002390 interchain disulfide; other site 512566002391 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 512566002392 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 512566002393 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 512566002394 RNA binding site [nucleotide binding]; other site 512566002395 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 512566002396 RNA binding site [nucleotide binding]; other site 512566002397 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 512566002398 RNA binding site [nucleotide binding]; other site 512566002399 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 512566002400 RNA binding site [nucleotide binding]; other site 512566002401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 512566002402 Transposase; Region: DDE_Tnp_ISL3; pfam01610 512566002403 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 512566002404 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 512566002405 GAF domain; Region: GAF_2; pfam13185 512566002406 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 512566002407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512566002408 Walker A motif; other site 512566002409 ATP binding site [chemical binding]; other site 512566002410 Walker B motif; other site 512566002411 arginine finger; other site 512566002412 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 512566002413 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 512566002414 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 512566002415 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 512566002416 Walker A/P-loop; other site 512566002417 ATP binding site [chemical binding]; other site 512566002418 Q-loop/lid; other site 512566002419 ABC transporter signature motif; other site 512566002420 Walker B; other site 512566002421 D-loop; other site 512566002422 H-loop/switch region; other site 512566002423 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 512566002424 FeS assembly protein SufD; Region: sufD; TIGR01981 512566002425 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 512566002426 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 512566002427 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512566002428 catalytic residue [active] 512566002429 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 512566002430 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 512566002431 trimerization site [polypeptide binding]; other site 512566002432 active site 512566002433 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 512566002434 FeS assembly protein SufB; Region: sufB; TIGR01980 512566002435 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 512566002436 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 512566002437 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 512566002438 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 512566002439 Domain of unknown function DUF20; Region: UPF0118; pfam01594 512566002440 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 512566002441 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 512566002442 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 512566002443 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 512566002444 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 512566002445 putative substrate binding site [chemical binding]; other site 512566002446 putative ATP binding site [chemical binding]; other site 512566002447 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 512566002448 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 512566002449 active site 512566002450 phosphorylation site [posttranslational modification] 512566002451 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 512566002452 active site 512566002453 P-loop; other site 512566002454 phosphorylation site [posttranslational modification] 512566002455 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 512566002456 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 512566002457 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 512566002458 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512566002459 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 512566002460 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 512566002461 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 512566002462 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 512566002463 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512566002464 catalytic residue [active] 512566002465 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 512566002466 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 512566002467 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 512566002468 Ligand Binding Site [chemical binding]; other site 512566002469 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 512566002470 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 512566002471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 512566002472 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 512566002473 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 512566002474 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 512566002475 HsdM N-terminal domain; Region: HsdM_N; pfam12161 512566002476 Methyltransferase domain; Region: Methyltransf_26; pfam13659 512566002477 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 512566002478 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 512566002479 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 512566002480 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 512566002481 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 512566002482 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 512566002483 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 512566002484 active site 512566002485 catalytic residues [active] 512566002486 DNA binding site [nucleotide binding] 512566002487 Int/Topo IB signature motif; other site 512566002488 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 512566002489 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 512566002490 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 512566002491 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 512566002492 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 512566002493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512566002494 ATP binding site [chemical binding]; other site 512566002495 putative Mg++ binding site [ion binding]; other site 512566002496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 512566002497 Arginine repressor [Transcription]; Region: ArgR; COG1438 512566002498 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 512566002499 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 512566002500 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 512566002501 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 512566002502 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 512566002503 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 512566002504 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 512566002505 active site 512566002506 PHP Thumb interface [polypeptide binding]; other site 512566002507 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 512566002508 generic binding surface II; other site 512566002509 generic binding surface I; other site 512566002510 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 512566002511 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 512566002512 active site 512566002513 ADP/pyrophosphate binding site [chemical binding]; other site 512566002514 dimerization interface [polypeptide binding]; other site 512566002515 allosteric effector site; other site 512566002516 fructose-1,6-bisphosphate binding site; other site 512566002517 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 512566002518 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 512566002519 domain interfaces; other site 512566002520 active site 512566002521 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 512566002522 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 512566002523 Predicted membrane protein [Function unknown]; Region: COG3689 512566002524 Predicted permeases [General function prediction only]; Region: COG0701 512566002525 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 512566002526 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 512566002527 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 512566002528 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 512566002529 RNA binding site [nucleotide binding]; other site 512566002530 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 512566002531 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512566002532 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512566002533 Walker A/P-loop; other site 512566002534 ATP binding site [chemical binding]; other site 512566002535 Q-loop/lid; other site 512566002536 ABC transporter signature motif; other site 512566002537 Walker B; other site 512566002538 D-loop; other site 512566002539 H-loop/switch region; other site 512566002540 FtsX-like permease family; Region: FtsX; pfam02687 512566002541 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 512566002542 Helix-turn-helix domain; Region: HTH_38; pfam13936 512566002543 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 512566002544 Integrase core domain; Region: rve; pfam00665 512566002545 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 512566002546 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 512566002547 homodimer interface [polypeptide binding]; other site 512566002548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512566002549 catalytic residue [active] 512566002550 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 512566002551 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 512566002552 Transposase; Region: DEDD_Tnp_IS110; pfam01548 512566002553 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 512566002554 spermidine synthase; Provisional; Region: PRK00811 512566002555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566002556 S-adenosylmethionine binding site [chemical binding]; other site 512566002557 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 512566002558 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 512566002559 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 512566002560 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 512566002561 dimer interface [polypeptide binding]; other site 512566002562 active site 512566002563 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 512566002564 catalytic residues [active] 512566002565 substrate binding site [chemical binding]; other site 512566002566 agmatine deiminase; Provisional; Region: PRK13551 512566002567 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 512566002568 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 512566002569 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 512566002570 putative active site; other site 512566002571 catalytic triad [active] 512566002572 putative dimer interface [polypeptide binding]; other site 512566002573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566002574 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 512566002575 active site 512566002576 motif I; other site 512566002577 motif II; other site 512566002578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566002579 CAAX protease self-immunity; Region: Abi; pfam02517 512566002580 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 512566002581 Transcriptional regulator [Transcription]; Region: LysR; COG0583 512566002582 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 512566002583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 512566002584 dimerization interface [polypeptide binding]; other site 512566002585 lipoprotein signal peptidase; Provisional; Region: PRK14797 512566002586 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 512566002587 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512566002588 RNA binding surface [nucleotide binding]; other site 512566002589 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 512566002590 active site 512566002591 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 512566002592 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 512566002593 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 512566002594 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 512566002595 nucleotide binding site [chemical binding]; other site 512566002596 homotetrameric interface [polypeptide binding]; other site 512566002597 putative phosphate binding site [ion binding]; other site 512566002598 putative allosteric binding site; other site 512566002599 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 512566002600 PUA domain; Region: PUA; pfam01472 512566002601 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 512566002602 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 512566002603 putative catalytic cysteine [active] 512566002604 pyrroline-5-carboxylate reductase; Region: PLN02688 512566002605 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 512566002606 thymidylate kinase; Validated; Region: tmk; PRK00698 512566002607 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 512566002608 TMP-binding site; other site 512566002609 ATP-binding site [chemical binding]; other site 512566002610 DNA polymerase III subunit delta'; Validated; Region: PRK07276 512566002611 DNA polymerase III subunit delta'; Validated; Region: PRK08485 512566002612 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 512566002613 Predicted methyltransferases [General function prediction only]; Region: COG0313 512566002614 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 512566002615 putative SAM binding site [chemical binding]; other site 512566002616 putative homodimer interface [polypeptide binding]; other site 512566002617 Uncharacterized conserved protein [Function unknown]; Region: COG4283 512566002618 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 512566002619 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 512566002620 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 512566002621 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 512566002622 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 512566002623 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 512566002624 Glucose inhibited division protein A; Region: GIDA; pfam01134 512566002625 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 512566002626 putative nucleotide binding site [chemical binding]; other site 512566002627 uridine monophosphate binding site [chemical binding]; other site 512566002628 homohexameric interface [polypeptide binding]; other site 512566002629 ribosome recycling factor; Reviewed; Region: frr; PRK00083 512566002630 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 512566002631 hinge region; other site 512566002632 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 512566002633 S1 domain; Region: S1_2; pfam13509 512566002634 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 512566002635 hypothetical protein; Provisional; Region: PRK13672 512566002636 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 512566002637 PhoH-like protein; Region: PhoH; pfam02562 512566002638 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512566002639 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512566002640 SLBB domain; Region: SLBB; pfam10531 512566002641 comEA protein; Region: comE; TIGR01259 512566002642 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 512566002643 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 512566002644 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 512566002645 Competence protein; Region: Competence; pfam03772 512566002646 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 512566002647 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 512566002648 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 512566002649 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512566002650 Walker A/P-loop; other site 512566002651 ATP binding site [chemical binding]; other site 512566002652 Q-loop/lid; other site 512566002653 ABC transporter signature motif; other site 512566002654 Walker B; other site 512566002655 D-loop; other site 512566002656 H-loop/switch region; other site 512566002657 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 512566002658 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 512566002659 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 512566002660 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 512566002661 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 512566002662 23S rRNA binding site [nucleotide binding]; other site 512566002663 L21 binding site [polypeptide binding]; other site 512566002664 L13 binding site [polypeptide binding]; other site 512566002665 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512566002666 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 512566002667 dimer interface [polypeptide binding]; other site 512566002668 active site 512566002669 metal binding site [ion binding]; metal-binding site 512566002670 glutathione binding site [chemical binding]; other site 512566002671 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 512566002672 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 512566002673 FAD binding pocket [chemical binding]; other site 512566002674 FAD binding motif [chemical binding]; other site 512566002675 phosphate binding motif [ion binding]; other site 512566002676 beta-alpha-beta structure motif; other site 512566002677 NAD binding pocket [chemical binding]; other site 512566002678 Iron coordination center [ion binding]; other site 512566002679 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 512566002680 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 512566002681 heterodimer interface [polypeptide binding]; other site 512566002682 active site 512566002683 FMN binding site [chemical binding]; other site 512566002684 homodimer interface [polypeptide binding]; other site 512566002685 substrate binding site [chemical binding]; other site 512566002686 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 512566002687 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 512566002688 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 512566002689 Domain of unknown function (DUF814); Region: DUF814; pfam05670 512566002690 metal-binding heat shock protein; Provisional; Region: PRK00016 512566002691 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 512566002692 GTPase Era; Reviewed; Region: era; PRK00089 512566002693 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 512566002694 G1 box; other site 512566002695 GTP/Mg2+ binding site [chemical binding]; other site 512566002696 Switch I region; other site 512566002697 G2 box; other site 512566002698 Switch II region; other site 512566002699 G3 box; other site 512566002700 G4 box; other site 512566002701 G5 box; other site 512566002702 KH domain; Region: KH_2; pfam07650 512566002703 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 512566002704 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 512566002705 DNA binding site [nucleotide binding] 512566002706 catalytic residue [active] 512566002707 H2TH interface [polypeptide binding]; other site 512566002708 putative catalytic residues [active] 512566002709 turnover-facilitating residue; other site 512566002710 intercalation triad [nucleotide binding]; other site 512566002711 8OG recognition residue [nucleotide binding]; other site 512566002712 putative reading head residues; other site 512566002713 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 512566002714 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 512566002715 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 512566002716 dephospho-CoA kinase; Region: TIGR00152 512566002717 CoA-binding site [chemical binding]; other site 512566002718 ATP-binding [chemical binding]; other site 512566002719 drug efflux system protein MdtG; Provisional; Region: PRK09874 512566002720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512566002721 putative substrate translocation pore; other site 512566002722 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 512566002723 ribonuclease R; Region: RNase_R; TIGR02063 512566002724 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 512566002725 RNB domain; Region: RNB; pfam00773 512566002726 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 512566002727 RNA binding site [nucleotide binding]; other site 512566002728 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 512566002729 SmpB-tmRNA interface; other site 512566002730 tellurite resistance protein TehB; Provisional; Region: PRK12335 512566002731 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 512566002732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566002733 S-adenosylmethionine binding site [chemical binding]; other site 512566002734 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 512566002735 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 512566002736 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 512566002737 active site 512566002738 Zn binding site [ion binding]; other site 512566002739 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 512566002740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566002741 S-adenosylmethionine binding site [chemical binding]; other site 512566002742 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 512566002743 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 512566002744 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 512566002745 Integrase core domain; Region: rve; pfam00665 512566002746 Integrase core domain; Region: rve_2; pfam13333 512566002747 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 512566002748 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512566002749 catalytic core [active] 512566002750 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 512566002751 putative deacylase active site [active] 512566002752 Predicted membrane protein [Function unknown]; Region: COG2035 512566002753 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 512566002754 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 512566002755 active site 512566002756 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 512566002757 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 512566002758 Substrate binding site; other site 512566002759 Mg++ binding site; other site 512566002760 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 512566002761 active site 512566002762 substrate binding site [chemical binding]; other site 512566002763 CoA binding site [chemical binding]; other site 512566002764 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 512566002765 dimer interface [polypeptide binding]; other site 512566002766 ADP-ribose binding site [chemical binding]; other site 512566002767 active site 512566002768 nudix motif; other site 512566002769 metal binding site [ion binding]; metal-binding site 512566002770 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 512566002771 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 512566002772 MarR family; Region: MarR_2; cl17246 512566002773 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 512566002774 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 512566002775 active site 512566002776 catalytic site [active] 512566002777 substrate binding site [chemical binding]; other site 512566002778 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 512566002779 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 512566002780 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 512566002781 putative active site [active] 512566002782 catalytic site [active] 512566002783 putative metal binding site [ion binding]; other site 512566002784 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 512566002785 Helix-turn-helix domain; Region: HTH_28; pfam13518 512566002786 Winged helix-turn helix; Region: HTH_29; pfam13551 512566002787 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 512566002788 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 512566002789 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 512566002790 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 512566002791 catalytic residues [active] 512566002792 amino acid transporter; Region: 2A0306; TIGR00909 512566002793 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 512566002794 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 512566002795 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 512566002796 metal binding site [ion binding]; metal-binding site 512566002797 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 512566002798 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 512566002799 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 512566002800 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 512566002801 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 512566002802 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 512566002803 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 512566002804 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 512566002805 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 512566002806 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 512566002807 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 512566002808 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 512566002809 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 512566002810 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 512566002811 metal binding site [ion binding]; metal-binding site 512566002812 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 512566002813 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 512566002814 active site 512566002815 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 512566002816 active site 512566002817 N-terminal domain interface [polypeptide binding]; other site 512566002818 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 512566002819 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 512566002820 Predicted membrane protein [Function unknown]; Region: COG2246 512566002821 GtrA-like protein; Region: GtrA; pfam04138 512566002822 Predicted membrane protein [Function unknown]; Region: COG4708 512566002823 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 512566002824 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 512566002825 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 512566002826 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 512566002827 dimer interface [polypeptide binding]; other site 512566002828 active site 512566002829 catalytic residue [active] 512566002830 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 512566002831 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 512566002832 trmE is a tRNA modification GTPase; Region: trmE; cd04164 512566002833 G1 box; other site 512566002834 GTP/Mg2+ binding site [chemical binding]; other site 512566002835 Switch I region; other site 512566002836 G2 box; other site 512566002837 Switch II region; other site 512566002838 G3 box; other site 512566002839 G4 box; other site 512566002840 G5 box; other site 512566002841 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 512566002842 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 512566002843 active site 1 [active] 512566002844 dimer interface [polypeptide binding]; other site 512566002845 hexamer interface [polypeptide binding]; other site 512566002846 active site 2 [active] 512566002847 thymidine kinase; Provisional; Region: PRK04296 512566002848 peptide chain release factor 1; Validated; Region: prfA; PRK00591 512566002849 This domain is found in peptide chain release factors; Region: PCRF; smart00937 512566002850 RF-1 domain; Region: RF-1; pfam00472 512566002851 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 512566002852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566002853 S-adenosylmethionine binding site [chemical binding]; other site 512566002854 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 512566002855 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 512566002856 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512566002857 Coenzyme A binding pocket [chemical binding]; other site 512566002858 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 512566002859 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 512566002860 dimer interface [polypeptide binding]; other site 512566002861 active site 512566002862 glycine-pyridoxal phosphate binding site [chemical binding]; other site 512566002863 folate binding site [chemical binding]; other site 512566002864 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 512566002865 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 512566002866 Lysozyme-like; Region: Lysozyme_like; pfam13702 512566002867 catalytic residue [active] 512566002868 Predicted secreted protein [Function unknown]; Region: COG4086 512566002869 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 512566002870 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 512566002871 TRAM domain; Region: TRAM; cl01282 512566002872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566002873 S-adenosylmethionine binding site [chemical binding]; other site 512566002874 Predicted transcriptional regulator [Transcription]; Region: COG3655 512566002875 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 512566002876 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 512566002877 siderophore binding site; other site 512566002878 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 512566002879 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512566002880 ABC-ATPase subunit interface; other site 512566002881 dimer interface [polypeptide binding]; other site 512566002882 putative PBP binding regions; other site 512566002883 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512566002884 ABC-ATPase subunit interface; other site 512566002885 dimer interface [polypeptide binding]; other site 512566002886 putative PBP binding regions; other site 512566002887 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 512566002888 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 512566002889 Walker A/P-loop; other site 512566002890 ATP binding site [chemical binding]; other site 512566002891 Q-loop/lid; other site 512566002892 ABC transporter signature motif; other site 512566002893 Walker B; other site 512566002894 D-loop; other site 512566002895 H-loop/switch region; other site 512566002896 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 512566002897 MobA/MobL family; Region: MobA_MobL; pfam03389 512566002898 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 512566002899 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 512566002900 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 512566002901 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 512566002902 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 512566002903 catalytic residues [active] 512566002904 catalytic nucleophile [active] 512566002905 Recombinase; Region: Recombinase; pfam07508 512566002906 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 512566002907 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 512566002908 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 512566002909 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 512566002910 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 512566002911 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 512566002912 homodimer interface [polypeptide binding]; other site 512566002913 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 512566002914 active site 512566002915 homodimer interface [polypeptide binding]; other site 512566002916 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 512566002917 Lantibiotic streptin immunity protein; Region: Streptin-Immun; pfam11083 512566002918 Helix-turn-helix domain; Region: HTH_19; pfam12844 512566002919 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 512566002920 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 512566002921 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 512566002922 NAD binding site [chemical binding]; other site 512566002923 UDP-glucose 4-epimerase; Region: PLN02240 512566002924 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 512566002925 NAD binding site [chemical binding]; other site 512566002926 homodimer interface [polypeptide binding]; other site 512566002927 active site 512566002928 substrate binding site [chemical binding]; other site 512566002929 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 512566002930 Ferroportin1 (FPN1); Region: FPN1; pfam06963 512566002931 H+ Antiporter protein; Region: 2A0121; TIGR00900 512566002932 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512566002933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566002934 sequence-specific DNA binding site [nucleotide binding]; other site 512566002935 salt bridge; other site 512566002936 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 512566002937 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 512566002938 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 512566002939 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 512566002940 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 512566002941 zinc binding site [ion binding]; other site 512566002942 putative ligand binding site [chemical binding]; other site 512566002943 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512566002944 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 512566002945 TM-ABC transporter signature motif; other site 512566002946 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 512566002947 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566002948 Walker A/P-loop; other site 512566002949 ATP binding site [chemical binding]; other site 512566002950 Q-loop/lid; other site 512566002951 ABC transporter signature motif; other site 512566002952 Walker B; other site 512566002953 D-loop; other site 512566002954 H-loop/switch region; other site 512566002955 DNA primase; Validated; Region: dnaG; PRK05667 512566002956 CHC2 zinc finger; Region: zf-CHC2; pfam01807 512566002957 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 512566002958 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 512566002959 active site 512566002960 metal binding site [ion binding]; metal-binding site 512566002961 interdomain interaction site; other site 512566002962 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 512566002963 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 512566002964 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 512566002965 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512566002966 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 512566002967 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 512566002968 DNA binding residues [nucleotide binding] 512566002969 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 512566002970 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512566002971 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 512566002972 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512566002973 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 512566002974 putative ADP-binding pocket [chemical binding]; other site 512566002975 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 512566002976 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 512566002977 GTPase CgtA; Reviewed; Region: obgE; PRK12297 512566002978 GTP1/OBG; Region: GTP1_OBG; pfam01018 512566002979 Obg GTPase; Region: Obg; cd01898 512566002980 G1 box; other site 512566002981 GTP/Mg2+ binding site [chemical binding]; other site 512566002982 Switch I region; other site 512566002983 G2 box; other site 512566002984 G3 box; other site 512566002985 Switch II region; other site 512566002986 G4 box; other site 512566002987 G5 box; other site 512566002988 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 512566002989 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 512566002990 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 512566002991 hinge; other site 512566002992 active site 512566002993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512566002994 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512566002995 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 512566002996 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512566002997 DNA-binding site [nucleotide binding]; DNA binding site 512566002998 DRTGG domain; Region: DRTGG; pfam07085 512566002999 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 512566003000 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 512566003001 active site 2 [active] 512566003002 active site 1 [active] 512566003003 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 512566003004 active site 512566003005 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 512566003006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 512566003007 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 512566003008 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 512566003009 Part of AAA domain; Region: AAA_19; pfam13245 512566003010 Family description; Region: UvrD_C_2; pfam13538 512566003011 hypothetical protein; Reviewed; Region: PRK00024 512566003012 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 512566003013 MPN+ (JAMM) motif; other site 512566003014 Zinc-binding site [ion binding]; other site 512566003015 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 512566003016 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 512566003017 catalytic triad [active] 512566003018 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 512566003019 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 512566003020 CoA binding domain; Region: CoA_binding; pfam02629 512566003021 Putative amino acid metabolism; Region: DUF1831; pfam08866 512566003022 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 512566003023 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 512566003024 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512566003025 catalytic residue [active] 512566003026 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 512566003027 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 512566003028 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512566003029 active site 512566003030 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 512566003031 putative active site [active] 512566003032 putative metal binding residues [ion binding]; other site 512566003033 signature motif; other site 512566003034 putative triphosphate binding site [ion binding]; other site 512566003035 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 512566003036 synthetase active site [active] 512566003037 NTP binding site [chemical binding]; other site 512566003038 metal binding site [ion binding]; metal-binding site 512566003039 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 512566003040 ATP-NAD kinase; Region: NAD_kinase; pfam01513 512566003041 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 512566003042 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 512566003043 RNA binding surface [nucleotide binding]; other site 512566003044 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 512566003045 active site 512566003046 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 512566003047 hypothetical protein; Validated; Region: PRK00153 512566003048 Predicted membrane protein [Function unknown]; Region: COG3619 512566003049 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 512566003050 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 512566003051 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 512566003052 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 512566003053 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 512566003054 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 512566003055 active site 512566003056 Riboflavin kinase; Region: Flavokinase; smart00904 512566003057 Uncharacterized conserved protein [Function unknown]; Region: COG1284 512566003058 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 512566003059 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 512566003060 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 512566003061 EDD domain protein, DegV family; Region: DegV; TIGR00762 512566003062 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 512566003063 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 512566003064 IHF dimer interface [polypeptide binding]; other site 512566003065 IHF - DNA interface [nucleotide binding]; other site 512566003066 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 512566003067 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512566003068 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512566003069 ABC transporter; Region: ABC_tran_2; pfam12848 512566003070 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512566003071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566003072 non-specific DNA binding site [nucleotide binding]; other site 512566003073 salt bridge; other site 512566003074 sequence-specific DNA binding site [nucleotide binding]; other site 512566003075 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 512566003076 H+ Antiporter protein; Region: 2A0121; TIGR00900 512566003077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512566003078 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 512566003079 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 512566003080 nucleotide binding pocket [chemical binding]; other site 512566003081 K-X-D-G motif; other site 512566003082 catalytic site [active] 512566003083 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 512566003084 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 512566003085 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 512566003086 Dimer interface [polypeptide binding]; other site 512566003087 BRCT sequence motif; other site 512566003088 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 512566003089 pullulanase, type I; Region: pulA_typeI; TIGR02104 512566003090 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 512566003091 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 512566003092 Ca binding site [ion binding]; other site 512566003093 active site 512566003094 catalytic site [active] 512566003095 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 512566003096 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 512566003097 tetrameric interface [polypeptide binding]; other site 512566003098 activator binding site; other site 512566003099 NADP binding site [chemical binding]; other site 512566003100 substrate binding site [chemical binding]; other site 512566003101 catalytic residues [active] 512566003102 glycogen branching enzyme; Provisional; Region: PRK12313 512566003103 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 512566003104 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 512566003105 active site 512566003106 catalytic site [active] 512566003107 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 512566003108 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 512566003109 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 512566003110 ligand binding site; other site 512566003111 oligomer interface; other site 512566003112 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 512566003113 dimer interface [polypeptide binding]; other site 512566003114 N-terminal domain interface [polypeptide binding]; other site 512566003115 sulfate 1 binding site; other site 512566003116 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 512566003117 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 512566003118 active site 512566003119 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 512566003120 dimer interface [polypeptide binding]; other site 512566003121 N-terminal domain interface [polypeptide binding]; other site 512566003122 sulfate 1 binding site; other site 512566003123 glycogen synthase; Provisional; Region: glgA; PRK00654 512566003124 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 512566003125 ADP-binding pocket [chemical binding]; other site 512566003126 homodimer interface [polypeptide binding]; other site 512566003127 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 512566003128 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 512566003129 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 512566003130 Uncharacterized conserved protein [Function unknown]; Region: COG5506 512566003131 enolase; Provisional; Region: eno; PRK00077 512566003132 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 512566003133 dimer interface [polypeptide binding]; other site 512566003134 metal binding site [ion binding]; metal-binding site 512566003135 substrate binding pocket [chemical binding]; other site 512566003136 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512566003137 DNA binding site [nucleotide binding] 512566003138 active site 512566003139 Int/Topo IB signature motif; other site 512566003140 Helix-turn-helix domain; Region: HTH_28; pfam13518 512566003141 Winged helix-turn helix; Region: HTH_29; pfam13551 512566003142 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 512566003143 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 512566003144 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 512566003145 Part of AAA domain; Region: AAA_19; pfam13245 512566003146 Family description; Region: UvrD_C_2; pfam13538 512566003147 Family description; Region: UvrD_C_2; pfam13538 512566003148 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 512566003149 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 512566003150 G5 domain; Region: G5; pfam07501 512566003151 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 512566003152 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 512566003153 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 512566003154 G5 domain; Region: G5; pfam07501 512566003155 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 512566003156 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 512566003157 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 512566003158 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 512566003159 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 512566003160 GTP/Mg2+ binding site [chemical binding]; other site 512566003161 G4 box; other site 512566003162 G5 box; other site 512566003163 G1 box; other site 512566003164 Switch I region; other site 512566003165 G2 box; other site 512566003166 G3 box; other site 512566003167 Switch II region; other site 512566003168 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 512566003169 RNA/DNA hybrid binding site [nucleotide binding]; other site 512566003170 active site 512566003171 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 512566003172 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 512566003173 Cl- selectivity filter; other site 512566003174 Cl- binding residues [ion binding]; other site 512566003175 pore gating glutamate residue; other site 512566003176 dimer interface [polypeptide binding]; other site 512566003177 H+/Cl- coupling transport residue; other site 512566003178 TrkA-C domain; Region: TrkA_C; pfam02080 512566003179 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 512566003180 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512566003181 active site 512566003182 DNA binding site [nucleotide binding] 512566003183 Int/Topo IB signature motif; other site 512566003184 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 512566003185 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 512566003186 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 512566003187 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 512566003188 E3 interaction surface; other site 512566003189 lipoyl attachment site [posttranslational modification]; other site 512566003190 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 512566003191 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 512566003192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512566003193 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 512566003194 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 512566003195 e3 binding domain; Region: E3_binding; pfam02817 512566003196 e3 binding domain; Region: E3_binding; pfam02817 512566003197 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 512566003198 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 512566003199 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 512566003200 alpha subunit interface [polypeptide binding]; other site 512566003201 TPP binding site [chemical binding]; other site 512566003202 heterodimer interface [polypeptide binding]; other site 512566003203 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 512566003204 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 512566003205 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 512566003206 tetramer interface [polypeptide binding]; other site 512566003207 TPP-binding site [chemical binding]; other site 512566003208 heterodimer interface [polypeptide binding]; other site 512566003209 phosphorylation loop region [posttranslational modification] 512566003210 multidrug efflux protein; Reviewed; Region: PRK01766 512566003211 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 512566003212 cation binding site [ion binding]; other site 512566003213 dihydroorotase; Validated; Region: pyrC; PRK09357 512566003214 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512566003215 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 512566003216 active site 512566003217 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 512566003218 putative active site [active] 512566003219 nucleotide binding site [chemical binding]; other site 512566003220 nudix motif; other site 512566003221 putative metal binding site [ion binding]; other site 512566003222 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 512566003223 ligand binding site [chemical binding]; other site 512566003224 active site 512566003225 UGI interface [polypeptide binding]; other site 512566003226 catalytic site [active] 512566003227 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 512566003228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566003229 motif II; other site 512566003230 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 512566003231 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 512566003232 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 512566003233 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 512566003234 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 512566003235 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 512566003236 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 512566003237 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 512566003238 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 512566003239 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 512566003240 dimerization domain swap beta strand [polypeptide binding]; other site 512566003241 regulatory protein interface [polypeptide binding]; other site 512566003242 active site 512566003243 regulatory phosphorylation site [posttranslational modification]; other site 512566003244 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 512566003245 catalytic residues [active] 512566003246 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 512566003247 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 512566003248 Class I ribonucleotide reductase; Region: RNR_I; cd01679 512566003249 active site 512566003250 dimer interface [polypeptide binding]; other site 512566003251 catalytic residues [active] 512566003252 effector binding site; other site 512566003253 R2 peptide binding site; other site 512566003254 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 512566003255 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 512566003256 dimer interface [polypeptide binding]; other site 512566003257 putative radical transfer pathway; other site 512566003258 diiron center [ion binding]; other site 512566003259 tyrosyl radical; other site 512566003260 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 512566003261 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 512566003262 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 512566003263 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 512566003264 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 512566003265 beta-galactosidase; Region: BGL; TIGR03356 512566003266 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 512566003267 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 512566003268 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 512566003269 active site 512566003270 P-loop; other site 512566003271 phosphorylation site [posttranslational modification] 512566003272 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 512566003273 methionine cluster; other site 512566003274 active site 512566003275 phosphorylation site [posttranslational modification] 512566003276 metal binding site [ion binding]; metal-binding site 512566003277 CAT RNA binding domain; Region: CAT_RBD; smart01061 512566003278 transcriptional antiterminator BglG; Provisional; Region: PRK09772 512566003279 PRD domain; Region: PRD; pfam00874 512566003280 PRD domain; Region: PRD; pfam00874 512566003281 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 512566003282 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 512566003283 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 512566003284 putative substrate binding site [chemical binding]; other site 512566003285 putative ATP binding site [chemical binding]; other site 512566003286 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 512566003287 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 512566003288 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 512566003289 catalytic residues [active] 512566003290 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 512566003291 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 512566003292 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 512566003293 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 512566003294 active site 512566003295 P-loop; other site 512566003296 phosphorylation site [posttranslational modification] 512566003297 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 512566003298 active site 512566003299 phosphorylation site [posttranslational modification] 512566003300 GTP-binding protein LepA; Provisional; Region: PRK05433 512566003301 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 512566003302 G1 box; other site 512566003303 putative GEF interaction site [polypeptide binding]; other site 512566003304 GTP/Mg2+ binding site [chemical binding]; other site 512566003305 Switch I region; other site 512566003306 G2 box; other site 512566003307 G3 box; other site 512566003308 Switch II region; other site 512566003309 G4 box; other site 512566003310 G5 box; other site 512566003311 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 512566003312 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 512566003313 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 512566003314 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 512566003315 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 512566003316 active site 512566003317 metal binding site [ion binding]; metal-binding site 512566003318 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 512566003319 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 512566003320 Walker A/P-loop; other site 512566003321 ATP binding site [chemical binding]; other site 512566003322 Q-loop/lid; other site 512566003323 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 512566003324 ABC transporter signature motif; other site 512566003325 Walker B; other site 512566003326 D-loop; other site 512566003327 H-loop/switch region; other site 512566003328 Arginine repressor [Transcription]; Region: ArgR; COG1438 512566003329 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 512566003330 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 512566003331 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 512566003332 S4 RNA-binding domain; Region: S4; smart00363 512566003333 RNA binding surface [nucleotide binding]; other site 512566003334 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 512566003335 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 512566003336 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 512566003337 substrate binding pocket [chemical binding]; other site 512566003338 chain length determination region; other site 512566003339 substrate-Mg2+ binding site; other site 512566003340 catalytic residues [active] 512566003341 aspartate-rich region 1; other site 512566003342 active site lid residues [active] 512566003343 aspartate-rich region 2; other site 512566003344 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 512566003345 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 512566003346 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 512566003347 generic binding surface II; other site 512566003348 generic binding surface I; other site 512566003349 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 512566003350 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 512566003351 Sugar specificity; other site 512566003352 Pyrimidine base specificity; other site 512566003353 ATP-binding site [chemical binding]; other site 512566003354 Enterocin A Immunity; Region: EntA_Immun; pfam08951 512566003355 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 512566003356 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 512566003357 RNA binding site [nucleotide binding]; other site 512566003358 active site 512566003359 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 512566003360 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 512566003361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 512566003362 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 512566003363 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 512566003364 hypothetical protein; Provisional; Region: PRK05939 512566003365 homodimer interface [polypeptide binding]; other site 512566003366 substrate-cofactor binding pocket; other site 512566003367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512566003368 catalytic residue [active] 512566003369 Dppa2/4 conserved region; Region: DCR; pfam14047 512566003370 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 512566003371 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 512566003372 active site 512566003373 catalytic site [active] 512566003374 DNA gyrase subunit A; Validated; Region: PRK05560 512566003375 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 512566003376 CAP-like domain; other site 512566003377 active site 512566003378 primary dimer interface [polypeptide binding]; other site 512566003379 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512566003380 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512566003381 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512566003382 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512566003383 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512566003384 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512566003385 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 512566003386 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 512566003387 tetramer (dimer of dimers) interface [polypeptide binding]; other site 512566003388 NAD binding site [chemical binding]; other site 512566003389 dimer interface [polypeptide binding]; other site 512566003390 substrate binding site [chemical binding]; other site 512566003391 Ion channel; Region: Ion_trans_2; pfam07885 512566003392 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 512566003393 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 512566003394 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 512566003395 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 512566003396 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 512566003397 putative active site [active] 512566003398 heme pocket [chemical binding]; other site 512566003399 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512566003400 dimer interface [polypeptide binding]; other site 512566003401 phosphorylation site [posttranslational modification] 512566003402 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566003403 ATP binding site [chemical binding]; other site 512566003404 Mg2+ binding site [ion binding]; other site 512566003405 G-X-G motif; other site 512566003406 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512566003407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512566003408 active site 512566003409 phosphorylation site [posttranslational modification] 512566003410 intermolecular recognition site; other site 512566003411 dimerization interface [polypeptide binding]; other site 512566003412 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512566003413 DNA binding site [nucleotide binding] 512566003414 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 512566003415 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 512566003416 minor groove reading motif; other site 512566003417 helix-hairpin-helix signature motif; other site 512566003418 substrate binding pocket [chemical binding]; other site 512566003419 active site 512566003420 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 512566003421 DNA binding and oxoG recognition site [nucleotide binding] 512566003422 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 512566003423 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 512566003424 Potassium binding sites [ion binding]; other site 512566003425 Cesium cation binding sites [ion binding]; other site 512566003426 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 512566003427 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 512566003428 Flavoprotein; Region: Flavoprotein; pfam02441 512566003429 Predicted membrane protein [Function unknown]; Region: COG4684 512566003430 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 512566003431 HTH domain; Region: HTH_11; pfam08279 512566003432 3H domain; Region: 3H; pfam02829 512566003433 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 512566003434 putative active site [active] 512566003435 nucleotide binding site [chemical binding]; other site 512566003436 nudix motif; other site 512566003437 putative metal binding site [ion binding]; other site 512566003438 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 512566003439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512566003440 Coenzyme A binding pocket [chemical binding]; other site 512566003441 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 512566003442 excinuclease ABC subunit B; Provisional; Region: PRK05298 512566003443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512566003444 ATP binding site [chemical binding]; other site 512566003445 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512566003446 nucleotide binding region [chemical binding]; other site 512566003447 ATP-binding site [chemical binding]; other site 512566003448 Ultra-violet resistance protein B; Region: UvrB; pfam12344 512566003449 UvrB/uvrC motif; Region: UVR; pfam02151 512566003450 CAAX protease self-immunity; Region: Abi; pfam02517 512566003451 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512566003452 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 512566003453 substrate binding pocket [chemical binding]; other site 512566003454 membrane-bound complex binding site; other site 512566003455 hinge residues; other site 512566003456 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512566003457 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 512566003458 substrate binding pocket [chemical binding]; other site 512566003459 membrane-bound complex binding site; other site 512566003460 hinge residues; other site 512566003461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566003462 dimer interface [polypeptide binding]; other site 512566003463 conserved gate region; other site 512566003464 putative PBP binding loops; other site 512566003465 ABC-ATPase subunit interface; other site 512566003466 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 512566003467 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 512566003468 Walker A/P-loop; other site 512566003469 ATP binding site [chemical binding]; other site 512566003470 Q-loop/lid; other site 512566003471 ABC transporter signature motif; other site 512566003472 Walker B; other site 512566003473 D-loop; other site 512566003474 H-loop/switch region; other site 512566003475 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 512566003476 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 512566003477 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 512566003478 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 512566003479 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 512566003480 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 512566003481 P loop; other site 512566003482 GTP binding site [chemical binding]; other site 512566003483 sugar phosphate phosphatase; Provisional; Region: PRK10513 512566003484 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566003485 motif II; other site 512566003486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566003487 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 512566003488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566003489 active site 512566003490 motif I; other site 512566003491 motif II; other site 512566003492 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 512566003493 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 512566003494 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 512566003495 Walker A/P-loop; other site 512566003496 ATP binding site [chemical binding]; other site 512566003497 Q-loop/lid; other site 512566003498 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 512566003499 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 512566003500 ABC transporter signature motif; other site 512566003501 Walker B; other site 512566003502 D-loop; other site 512566003503 H-loop/switch region; other site 512566003504 ribonuclease III; Reviewed; Region: rnc; PRK00102 512566003505 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 512566003506 dimerization interface [polypeptide binding]; other site 512566003507 active site 512566003508 metal binding site [ion binding]; metal-binding site 512566003509 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 512566003510 dsRNA binding site [nucleotide binding]; other site 512566003511 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 512566003512 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 512566003513 active site 512566003514 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 512566003515 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 512566003516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512566003517 Walker A motif; other site 512566003518 ATP binding site [chemical binding]; other site 512566003519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 512566003520 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 512566003521 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 512566003522 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 512566003523 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 512566003524 substrate binding site [chemical binding]; other site 512566003525 Predicted membrane protein [Function unknown]; Region: COG3326 512566003526 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 512566003527 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 512566003528 2-isopropylmalate synthase; Validated; Region: PRK00915 512566003529 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 512566003530 metal binding site [ion binding]; metal-binding site 512566003531 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 512566003532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 512566003533 CutC family; Region: CutC; cl01218 512566003534 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 512566003535 DNA topoisomerase I; Validated; Region: PRK05582 512566003536 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 512566003537 active site 512566003538 interdomain interaction site; other site 512566003539 putative metal-binding site [ion binding]; other site 512566003540 nucleotide binding site [chemical binding]; other site 512566003541 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 512566003542 domain I; other site 512566003543 DNA binding groove [nucleotide binding] 512566003544 phosphate binding site [ion binding]; other site 512566003545 domain II; other site 512566003546 domain III; other site 512566003547 nucleotide binding site [chemical binding]; other site 512566003548 catalytic site [active] 512566003549 domain IV; other site 512566003550 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 512566003551 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 512566003552 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 512566003553 Predicted membrane protein [Function unknown]; Region: COG1808 512566003554 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 512566003555 DNA protecting protein DprA; Region: dprA; TIGR00732 512566003556 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 512566003557 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 512566003558 active site 512566003559 metal-binding site 512566003560 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 512566003561 Phosphotransferase enzyme family; Region: APH; pfam01636 512566003562 active site 512566003563 substrate binding site [chemical binding]; other site 512566003564 ATP binding site [chemical binding]; other site 512566003565 dimer interface [polypeptide binding]; other site 512566003566 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 512566003567 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 512566003568 putative NAD(P) binding site [chemical binding]; other site 512566003569 putative catalytic Zn binding site [ion binding]; other site 512566003570 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 512566003571 substrate binding site; other site 512566003572 dimer interface; other site 512566003573 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 512566003574 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 512566003575 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 512566003576 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 512566003577 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 512566003578 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 512566003579 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 512566003580 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 512566003581 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 512566003582 ATP-grasp domain; Region: ATP-grasp_4; cl17255 512566003583 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 512566003584 IMP binding site; other site 512566003585 dimer interface [polypeptide binding]; other site 512566003586 interdomain contacts; other site 512566003587 partial ornithine binding site; other site 512566003588 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 512566003589 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 512566003590 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 512566003591 catalytic site [active] 512566003592 subunit interface [polypeptide binding]; other site 512566003593 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 512566003594 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 512566003595 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 512566003596 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 512566003597 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512566003598 active site 512566003599 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 512566003600 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 512566003601 minor groove reading motif; other site 512566003602 helix-hairpin-helix signature motif; other site 512566003603 substrate binding pocket [chemical binding]; other site 512566003604 active site 512566003605 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 512566003606 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 512566003607 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512566003608 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512566003609 heat shock protein HtpX; Provisional; Region: PRK04897 512566003610 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 512566003611 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 512566003612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566003613 S-adenosylmethionine binding site [chemical binding]; other site 512566003614 uracil transporter; Provisional; Region: PRK10720 512566003615 signal recognition particle protein; Provisional; Region: PRK10867 512566003616 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 512566003617 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 512566003618 P loop; other site 512566003619 GTP binding site [chemical binding]; other site 512566003620 Signal peptide binding domain; Region: SRP_SPB; pfam02978 512566003621 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 512566003622 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 512566003623 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 512566003624 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 512566003625 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 512566003626 Zn2+ binding site [ion binding]; other site 512566003627 Mg2+ binding site [ion binding]; other site 512566003628 sugar phosphate phosphatase; Provisional; Region: PRK10513 512566003629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566003630 active site 512566003631 motif I; other site 512566003632 motif II; other site 512566003633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566003634 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 512566003635 camphor resistance protein CrcB; Provisional; Region: PRK14229 512566003636 camphor resistance protein CrcB; Provisional; Region: PRK14221 512566003637 hypothetical protein; Provisional; Region: PRK07248 512566003638 flavodoxin; Validated; Region: PRK07308 512566003639 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 512566003640 DHH family; Region: DHH; pfam01368 512566003641 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 512566003642 Winged helix-turn helix; Region: HTH_29; pfam13551 512566003643 Homeodomain-like domain; Region: HTH_23; pfam13384 512566003644 Homeodomain-like domain; Region: HTH_32; pfam13565 512566003645 glutamate dehydrogenase; Provisional; Region: PRK09414 512566003646 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 512566003647 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 512566003648 NAD(P) binding site [chemical binding]; other site 512566003649 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566003650 ABC transporter signature motif; other site 512566003651 Walker B; other site 512566003652 D-loop; other site 512566003653 H-loop/switch region; other site 512566003654 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 512566003655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 512566003656 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 512566003657 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 512566003658 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 512566003659 DDE superfamily endonuclease; Region: DDE_3; pfam13358 512566003660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 512566003661 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 512566003662 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 512566003663 V-type ATP synthase subunit B; Provisional; Region: PRK04196 512566003664 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 512566003665 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 512566003666 Walker A motif homologous position; other site 512566003667 Walker B motif; other site 512566003668 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 512566003669 V-type ATP synthase subunit A; Provisional; Region: PRK04192 512566003670 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 512566003671 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 512566003672 Walker A motif/ATP binding site; other site 512566003673 Walker B motif; other site 512566003674 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 512566003675 V-type ATP synthase subunit F; Provisional; Region: PRK01395 512566003676 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 512566003677 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 512566003678 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 512566003679 V-type ATP synthase subunit K; Validated; Region: PRK06558 512566003680 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 512566003681 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 512566003682 V-type ATP synthase subunit I; Validated; Region: PRK05771 512566003683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512566003684 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512566003685 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512566003686 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 512566003687 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512566003688 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 512566003689 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 512566003690 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 512566003691 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 512566003692 Asp-box motif; other site 512566003693 catalytic site [active] 512566003694 Domain of unknown function (DUF386); Region: DUF386; pfam04074 512566003695 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 512566003696 Na binding site [ion binding]; other site 512566003697 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 512566003698 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 512566003699 inhibitor site; inhibition site 512566003700 active site 512566003701 dimer interface [polypeptide binding]; other site 512566003702 catalytic residue [active] 512566003703 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 512566003704 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 512566003705 putative active site cavity [active] 512566003706 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 512566003707 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 512566003708 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 512566003709 putative active site [active] 512566003710 CAAX protease self-immunity; Region: Abi; pfam02517 512566003711 Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393 512566003712 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 512566003713 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 512566003714 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 512566003715 G1 box; other site 512566003716 putative GEF interaction site [polypeptide binding]; other site 512566003717 GTP/Mg2+ binding site [chemical binding]; other site 512566003718 Switch I region; other site 512566003719 G2 box; other site 512566003720 G3 box; other site 512566003721 Switch II region; other site 512566003722 G4 box; other site 512566003723 G5 box; other site 512566003724 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 512566003725 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 512566003726 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 512566003727 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 512566003728 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 512566003729 N-acetyl-D-glucosamine binding site [chemical binding]; other site 512566003730 catalytic residue [active] 512566003731 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 512566003732 NlpC/P60 family; Region: NLPC_P60; pfam00877 512566003733 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 512566003734 Haemolysin-III related; Region: HlyIII; cl03831 512566003735 AAA-like domain; Region: AAA_10; pfam12846 512566003736 TcpE family; Region: TcpE; pfam12648 512566003737 Antirestriction protein (ArdA); Region: ArdA; pfam07275 512566003738 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 512566003739 Transposase; Region: DDE_Tnp_ISL3; pfam01610 512566003740 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 512566003741 Transposase; Region: DDE_Tnp_ISL3; pfam01610 512566003742 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 512566003743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566003744 S-adenosylmethionine binding site [chemical binding]; other site 512566003745 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566003746 non-specific DNA binding site [nucleotide binding]; other site 512566003747 salt bridge; other site 512566003748 sequence-specific DNA binding site [nucleotide binding]; other site 512566003749 Replication initiation factor; Region: Rep_trans; pfam02486 512566003750 Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764 512566003751 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 512566003752 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 512566003753 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 512566003754 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 512566003755 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512566003756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566003757 non-specific DNA binding site [nucleotide binding]; other site 512566003758 salt bridge; other site 512566003759 sequence-specific DNA binding site [nucleotide binding]; other site 512566003760 Lantibiotic streptin immunity protein; Region: Streptin-Immun; pfam11083 512566003761 Lantibiotic streptin immunity protein; Region: Streptin-Immun; pfam11083 512566003762 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 512566003763 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 512566003764 Divergent AAA domain; Region: AAA_4; pfam04326 512566003765 Part of AAA domain; Region: AAA_19; pfam13245 512566003766 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 512566003767 Family description; Region: UvrD_C_2; pfam13538 512566003768 AAA ATPase domain; Region: AAA_15; pfam13175 512566003769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566003770 Walker A/P-loop; other site 512566003771 ATP binding site [chemical binding]; other site 512566003772 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 512566003773 putative active site [active] 512566003774 putative metal-binding site [ion binding]; other site 512566003775 Domain of unknown function (DUF4071); Region: DUF4071; pfam13281 512566003776 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 512566003777 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 512566003778 active site 512566003779 DNA binding site [nucleotide binding] 512566003780 Int/Topo IB signature motif; other site 512566003781 Zeta toxin; Region: Zeta_toxin; pfam06414 512566003782 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 512566003783 Transposase; Region: DDE_Tnp_ISL3; pfam01610 512566003784 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 512566003785 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 512566003786 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 512566003787 Toprim-like; Region: Toprim_2; pfam13155 512566003788 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512566003789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566003790 non-specific DNA binding site [nucleotide binding]; other site 512566003791 salt bridge; other site 512566003792 sequence-specific DNA binding site [nucleotide binding]; other site 512566003793 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 512566003794 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512566003795 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512566003796 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 512566003797 Walker A/P-loop; other site 512566003798 ATP binding site [chemical binding]; other site 512566003799 Q-loop/lid; other site 512566003800 ABC transporter signature motif; other site 512566003801 Walker B; other site 512566003802 D-loop; other site 512566003803 H-loop/switch region; other site 512566003804 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 512566003805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566003806 S-adenosylmethionine binding site [chemical binding]; other site 512566003807 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 512566003808 DEAD-like helicases superfamily; Region: DEXDc; smart00487 512566003809 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 512566003810 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 512566003811 helicase superfamily c-terminal domain; Region: HELICc; smart00490 512566003812 Peptidase family M23; Region: Peptidase_M23; pfam01551 512566003813 CHAP domain; Region: CHAP; pfam05257 512566003814 AAA-like domain; Region: AAA_10; pfam12846 512566003815 PrgI family protein; Region: PrgI; pfam12666 512566003816 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 512566003817 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 512566003818 Walker A motif; other site 512566003819 ATP binding site [chemical binding]; other site 512566003820 Walker B motif; other site 512566003821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566003822 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 512566003823 Walker A/P-loop; other site 512566003824 ATP binding site [chemical binding]; other site 512566003825 Q-loop/lid; other site 512566003826 ABC transporter signature motif; other site 512566003827 Walker B; other site 512566003828 D-loop; other site 512566003829 H-loop/switch region; other site 512566003830 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 512566003831 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 512566003832 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 512566003833 CAAX protease self-immunity; Region: Abi; pfam02517 512566003834 Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393 512566003835 ArsC family; Region: ArsC; pfam03960 512566003836 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 512566003837 cofactor binding site; other site 512566003838 DNA binding site [nucleotide binding] 512566003839 substrate interaction site [chemical binding]; other site 512566003840 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 512566003841 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 512566003842 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 512566003843 core dimer interface [polypeptide binding]; other site 512566003844 L10 interface [polypeptide binding]; other site 512566003845 L11 interface [polypeptide binding]; other site 512566003846 putative EF-Tu interaction site [polypeptide binding]; other site 512566003847 putative EF-G interaction site [polypeptide binding]; other site 512566003848 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 512566003849 23S rRNA interface [nucleotide binding]; other site 512566003850 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 512566003851 chlorohydrolase; Validated; Region: PRK06687 512566003852 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 512566003853 active site 512566003854 putative substrate binding pocket [chemical binding]; other site 512566003855 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512566003856 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512566003857 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 512566003858 Walker A/P-loop; other site 512566003859 ATP binding site [chemical binding]; other site 512566003860 Q-loop/lid; other site 512566003861 ABC transporter signature motif; other site 512566003862 Walker B; other site 512566003863 D-loop; other site 512566003864 H-loop/switch region; other site 512566003865 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512566003866 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512566003867 APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination; Region: APC10-like; cl02148 512566003868 putative ligand binding site [chemical binding]; other site 512566003869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566003870 Walker A/P-loop; other site 512566003871 ATP binding site [chemical binding]; other site 512566003872 Q-loop/lid; other site 512566003873 ABC transporter signature motif; other site 512566003874 Walker B; other site 512566003875 D-loop; other site 512566003876 H-loop/switch region; other site 512566003877 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 512566003878 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 512566003879 SelR domain; Region: SelR; pfam01641 512566003880 homoserine kinase; Provisional; Region: PRK01212 512566003881 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 512566003882 homoserine dehydrogenase; Provisional; Region: PRK06349 512566003883 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 512566003884 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 512566003885 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 512566003886 adaptor protein; Provisional; Region: PRK02315 512566003887 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 512566003888 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 512566003889 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 512566003890 active site 512566003891 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 512566003892 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 512566003893 putative ADP-binding pocket [chemical binding]; other site 512566003894 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 512566003895 Transcriptional regulator [Transcription]; Region: LytR; COG1316 512566003896 prephenate dehydratase; Provisional; Region: PRK11898 512566003897 Prephenate dehydratase; Region: PDT; pfam00800 512566003898 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 512566003899 putative L-Phe binding site [chemical binding]; other site 512566003900 shikimate kinase; Reviewed; Region: aroK; PRK00131 512566003901 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 512566003902 ADP binding site [chemical binding]; other site 512566003903 magnesium binding site [ion binding]; other site 512566003904 putative shikimate binding site; other site 512566003905 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 512566003906 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 512566003907 hinge; other site 512566003908 active site 512566003909 hypothetical protein; Provisional; Region: PRK13676 512566003910 prephenate dehydrogenase; Validated; Region: PRK06545 512566003911 prephenate dehydrogenase; Validated; Region: PRK08507 512566003912 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 512566003913 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 512566003914 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 512566003915 Tetramer interface [polypeptide binding]; other site 512566003916 active site 512566003917 FMN-binding site [chemical binding]; other site 512566003918 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 512566003919 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 512566003920 active site 512566003921 dimer interface [polypeptide binding]; other site 512566003922 metal binding site [ion binding]; metal-binding site 512566003923 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 512566003924 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 512566003925 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 512566003926 shikimate binding site; other site 512566003927 NAD(P) binding site [chemical binding]; other site 512566003928 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 512566003929 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 512566003930 active site 512566003931 catalytic residue [active] 512566003932 dimer interface [polypeptide binding]; other site 512566003933 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 512566003934 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 512566003935 putative RNA binding site [nucleotide binding]; other site 512566003936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566003937 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 512566003938 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512566003939 Walker A/P-loop; other site 512566003940 ATP binding site [chemical binding]; other site 512566003941 Q-loop/lid; other site 512566003942 ABC transporter signature motif; other site 512566003943 Walker B; other site 512566003944 D-loop; other site 512566003945 H-loop/switch region; other site 512566003946 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 512566003947 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 512566003948 active site 512566003949 Na/Ca binding site [ion binding]; other site 512566003950 catalytic site [active] 512566003951 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 512566003952 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 512566003953 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 512566003954 motif 1; other site 512566003955 active site 512566003956 motif 2; other site 512566003957 motif 3; other site 512566003958 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 512566003959 DHHA1 domain; Region: DHHA1; pfam02272 512566003960 Uncharacterized conserved protein [Function unknown]; Region: COG4894 512566003961 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 512566003962 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 512566003963 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 512566003964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566003965 dimer interface [polypeptide binding]; other site 512566003966 conserved gate region; other site 512566003967 putative PBP binding loops; other site 512566003968 ABC-ATPase subunit interface; other site 512566003969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566003970 dimer interface [polypeptide binding]; other site 512566003971 conserved gate region; other site 512566003972 putative PBP binding loops; other site 512566003973 ABC-ATPase subunit interface; other site 512566003974 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 512566003975 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 512566003976 Walker A/P-loop; other site 512566003977 ATP binding site [chemical binding]; other site 512566003978 Q-loop/lid; other site 512566003979 ABC transporter signature motif; other site 512566003980 Walker B; other site 512566003981 D-loop; other site 512566003982 H-loop/switch region; other site 512566003983 TOBE domain; Region: TOBE_2; pfam08402 512566003984 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 512566003985 FAD binding domain; Region: FAD_binding_4; pfam01565 512566003986 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 512566003987 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 512566003988 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 512566003989 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 512566003990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512566003991 DNA-binding site [nucleotide binding]; DNA binding site 512566003992 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512566003993 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 512566003994 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 512566003995 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512566003996 catalytic residue [active] 512566003997 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512566003998 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 512566003999 substrate binding pocket [chemical binding]; other site 512566004000 membrane-bound complex binding site; other site 512566004001 hinge residues; other site 512566004002 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 512566004003 PhoU domain; Region: PhoU; pfam01895 512566004004 PhoU domain; Region: PhoU; pfam01895 512566004005 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 512566004006 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 512566004007 Walker A/P-loop; other site 512566004008 ATP binding site [chemical binding]; other site 512566004009 Q-loop/lid; other site 512566004010 ABC transporter signature motif; other site 512566004011 Walker B; other site 512566004012 D-loop; other site 512566004013 H-loop/switch region; other site 512566004014 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 512566004015 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 512566004016 Walker A/P-loop; other site 512566004017 ATP binding site [chemical binding]; other site 512566004018 Q-loop/lid; other site 512566004019 ABC transporter signature motif; other site 512566004020 Walker B; other site 512566004021 D-loop; other site 512566004022 H-loop/switch region; other site 512566004023 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 512566004024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566004025 dimer interface [polypeptide binding]; other site 512566004026 conserved gate region; other site 512566004027 putative PBP binding loops; other site 512566004028 ABC-ATPase subunit interface; other site 512566004029 sulfate transport protein; Provisional; Region: cysT; CHL00187 512566004030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566004031 dimer interface [polypeptide binding]; other site 512566004032 conserved gate region; other site 512566004033 putative PBP binding loops; other site 512566004034 ABC-ATPase subunit interface; other site 512566004035 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 512566004036 phosphate binding protein; Region: ptsS_2; TIGR02136 512566004037 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 512566004038 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566004039 S-adenosylmethionine binding site [chemical binding]; other site 512566004040 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 512566004041 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 512566004042 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 512566004043 active site 512566004044 hypothetical protein; Provisional; Region: PRK04387 512566004045 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 512566004046 ArsC family; Region: ArsC; pfam03960 512566004047 putative catalytic residues [active] 512566004048 thiol/disulfide switch; other site 512566004049 Predicted membrane protein [Function unknown]; Region: COG4478 512566004050 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 512566004051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566004052 active site 512566004053 motif I; other site 512566004054 motif II; other site 512566004055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566004056 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 512566004057 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 512566004058 active site 512566004059 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 512566004060 active site 512566004061 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 512566004062 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512566004063 FeS/SAM binding site; other site 512566004064 HemN C-terminal domain; Region: HemN_C; pfam06969 512566004065 YtxH-like protein; Region: YtxH; pfam12732 512566004066 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 512566004067 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 512566004068 HPr kinase/phosphorylase; Provisional; Region: PRK05428 512566004069 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 512566004070 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 512566004071 Hpr binding site; other site 512566004072 active site 512566004073 homohexamer subunit interaction site [polypeptide binding]; other site 512566004074 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 512566004075 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 512566004076 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 512566004077 active site 512566004078 trimer interface [polypeptide binding]; other site 512566004079 allosteric site; other site 512566004080 active site lid [active] 512566004081 hexamer (dimer of trimers) interface [polypeptide binding]; other site 512566004082 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 512566004083 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 512566004084 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 512566004085 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566004086 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512566004087 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 512566004088 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 512566004089 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 512566004090 homodimer interface [polypeptide binding]; other site 512566004091 NAD binding pocket [chemical binding]; other site 512566004092 ATP binding pocket [chemical binding]; other site 512566004093 Mg binding site [ion binding]; other site 512566004094 active-site loop [active] 512566004095 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 512566004096 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 512566004097 active site 512566004098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566004099 non-specific DNA binding site [nucleotide binding]; other site 512566004100 salt bridge; other site 512566004101 sequence-specific DNA binding site [nucleotide binding]; other site 512566004102 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566004103 ABC transporter; Region: ABC_tran; pfam00005 512566004104 Q-loop/lid; other site 512566004105 ABC transporter signature motif; other site 512566004106 Walker B; other site 512566004107 D-loop; other site 512566004108 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 512566004109 Peptidase family U32; Region: Peptidase_U32; pfam01136 512566004110 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 512566004111 Peptidase family U32; Region: Peptidase_U32; pfam01136 512566004112 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 512566004113 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 512566004114 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 512566004115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566004116 S-adenosylmethionine binding site [chemical binding]; other site 512566004117 GMP synthase; Reviewed; Region: guaA; PRK00074 512566004118 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 512566004119 AMP/PPi binding site [chemical binding]; other site 512566004120 candidate oxyanion hole; other site 512566004121 catalytic triad [active] 512566004122 potential glutamine specificity residues [chemical binding]; other site 512566004123 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 512566004124 ATP Binding subdomain [chemical binding]; other site 512566004125 Dimerization subdomain; other site 512566004126 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 512566004127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512566004128 DNA-binding site [nucleotide binding]; DNA binding site 512566004129 UTRA domain; Region: UTRA; pfam07702 512566004130 EamA-like transporter family; Region: EamA; pfam00892 512566004131 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 512566004132 Beta-lactamase; Region: Beta-lactamase; pfam00144 512566004133 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 512566004134 active site 512566004135 catalytic triad [active] 512566004136 oxyanion hole [active] 512566004137 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 512566004138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566004139 active site 512566004140 motif I; other site 512566004141 motif II; other site 512566004142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566004143 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 512566004144 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 512566004145 putative active site [active] 512566004146 putative metal binding site [ion binding]; other site 512566004147 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 512566004148 active site 512566004149 catalytic residues [active] 512566004150 metal binding site [ion binding]; metal-binding site 512566004151 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 512566004152 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 512566004153 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 512566004154 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 512566004155 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512566004156 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512566004157 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 512566004158 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 512566004159 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 512566004160 Walker A/P-loop; other site 512566004161 ATP binding site [chemical binding]; other site 512566004162 Q-loop/lid; other site 512566004163 ABC transporter signature motif; other site 512566004164 Walker B; other site 512566004165 D-loop; other site 512566004166 H-loop/switch region; other site 512566004167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512566004168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566004169 ABC-ATPase subunit interface; other site 512566004170 putative PBP binding loops; other site 512566004171 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 512566004172 putative ArsC-like catalytic residues; other site 512566004173 putative TRX-like catalytic residues [active] 512566004174 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 512566004175 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 512566004176 DNA binding site [nucleotide binding] 512566004177 active site 512566004178 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 512566004179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512566004180 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 512566004181 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 512566004182 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 512566004183 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 512566004184 predicted active site [active] 512566004185 catalytic triad [active] 512566004186 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 512566004187 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 512566004188 active site 512566004189 multimer interface [polypeptide binding]; other site 512566004190 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 512566004191 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 512566004192 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 512566004193 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 512566004194 ApbE family; Region: ApbE; pfam02424 512566004195 Predicted flavoprotein [General function prediction only]; Region: COG0431 512566004196 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 512566004197 Predicted flavoprotein [General function prediction only]; Region: COG0431 512566004198 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 512566004199 PAS domain; Region: PAS_10; pfam13596 512566004200 hypothetical protein; Provisional; Region: PRK02539 512566004201 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 512566004202 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 512566004203 DALR anticodon binding domain; Region: DALR_1; pfam05746 512566004204 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 512566004205 dimer interface [polypeptide binding]; other site 512566004206 motif 1; other site 512566004207 active site 512566004208 motif 2; other site 512566004209 motif 3; other site 512566004210 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 512566004211 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 512566004212 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 512566004213 active site 512566004214 catalytic tetrad [active] 512566004215 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 512566004216 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 512566004217 NodB motif; other site 512566004218 active site 512566004219 catalytic site [active] 512566004220 Zn binding site [ion binding]; other site 512566004221 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 512566004222 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512566004223 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 512566004224 DEAD-like helicases superfamily; Region: DEXDc; smart00487 512566004225 ATP binding site [chemical binding]; other site 512566004226 putative Mg++ binding site [ion binding]; other site 512566004227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512566004228 nucleotide binding region [chemical binding]; other site 512566004229 ATP-binding site [chemical binding]; other site 512566004230 DDE superfamily endonuclease; Region: DDE_3; pfam13358 512566004231 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 512566004232 Winged helix-turn helix; Region: HTH_29; pfam13551 512566004233 elongation factor Tu; Reviewed; Region: PRK00049 512566004234 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 512566004235 G1 box; other site 512566004236 GEF interaction site [polypeptide binding]; other site 512566004237 GTP/Mg2+ binding site [chemical binding]; other site 512566004238 Switch I region; other site 512566004239 G2 box; other site 512566004240 G3 box; other site 512566004241 Switch II region; other site 512566004242 G4 box; other site 512566004243 G5 box; other site 512566004244 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 512566004245 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 512566004246 Antibiotic Binding Site [chemical binding]; other site 512566004247 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 512566004248 amphipathic channel; other site 512566004249 Asn-Pro-Ala signature motifs; other site 512566004250 MucBP domain; Region: MucBP; pfam06458 512566004251 DDE superfamily endonuclease; Region: DDE_3; pfam13358 512566004252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 512566004253 Transposase; Region: HTH_Tnp_IS630; pfam01710 512566004254 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 512566004255 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 512566004256 active site 512566004257 substrate binding site [chemical binding]; other site 512566004258 metal binding site [ion binding]; metal-binding site 512566004259 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 512566004260 catalytic residues [active] 512566004261 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 512566004262 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 512566004263 substrate binding pocket [chemical binding]; other site 512566004264 membrane-bound complex binding site; other site 512566004265 hinge residues; other site 512566004266 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512566004267 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566004268 Walker A/P-loop; other site 512566004269 ATP binding site [chemical binding]; other site 512566004270 Q-loop/lid; other site 512566004271 ABC transporter signature motif; other site 512566004272 Walker B; other site 512566004273 D-loop; other site 512566004274 H-loop/switch region; other site 512566004275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566004276 dimer interface [polypeptide binding]; other site 512566004277 conserved gate region; other site 512566004278 putative PBP binding loops; other site 512566004279 ABC-ATPase subunit interface; other site 512566004280 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 512566004281 binding surface 512566004282 TPR motif; other site 512566004283 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 512566004284 Domain of unknown function DUF20; Region: UPF0118; pfam01594 512566004285 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 512566004286 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 512566004287 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 512566004288 gamma subunit interface [polypeptide binding]; other site 512566004289 epsilon subunit interface [polypeptide binding]; other site 512566004290 LBP interface [polypeptide binding]; other site 512566004291 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 512566004292 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 512566004293 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 512566004294 alpha subunit interaction interface [polypeptide binding]; other site 512566004295 Walker A motif; other site 512566004296 ATP binding site [chemical binding]; other site 512566004297 Walker B motif; other site 512566004298 inhibitor binding site; inhibition site 512566004299 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 512566004300 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 512566004301 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 512566004302 core domain interface [polypeptide binding]; other site 512566004303 delta subunit interface [polypeptide binding]; other site 512566004304 epsilon subunit interface [polypeptide binding]; other site 512566004305 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 512566004306 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 512566004307 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 512566004308 beta subunit interaction interface [polypeptide binding]; other site 512566004309 Walker A motif; other site 512566004310 ATP binding site [chemical binding]; other site 512566004311 Walker B motif; other site 512566004312 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 512566004313 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 512566004314 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 512566004315 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 512566004316 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 512566004317 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 512566004318 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 512566004319 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 512566004320 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 512566004321 Helix-turn-helix domain; Region: HTH_38; pfam13936 512566004322 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 512566004323 Integrase core domain; Region: rve; pfam00665 512566004324 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512566004325 Coenzyme A binding pocket [chemical binding]; other site 512566004326 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 512566004327 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 512566004328 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 512566004329 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 512566004330 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 512566004331 dimerization interface [polypeptide binding]; other site 512566004332 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 512566004333 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512566004334 Coenzyme A binding pocket [chemical binding]; other site 512566004335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512566004336 Coenzyme A binding pocket [chemical binding]; other site 512566004337 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 512566004338 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 512566004339 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 512566004340 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 512566004341 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 512566004342 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 512566004343 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512566004344 ATP binding site [chemical binding]; other site 512566004345 putative Mg++ binding site [ion binding]; other site 512566004346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512566004347 nucleotide binding region [chemical binding]; other site 512566004348 ATP-binding site [chemical binding]; other site 512566004349 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 512566004350 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512566004351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512566004352 homodimer interface [polypeptide binding]; other site 512566004353 catalytic residue [active] 512566004354 cystathionine gamma-synthase; Reviewed; Region: PRK07269 512566004355 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 512566004356 homodimer interface [polypeptide binding]; other site 512566004357 substrate-cofactor binding pocket; other site 512566004358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512566004359 catalytic residue [active] 512566004360 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512566004361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566004362 Q-loop/lid; other site 512566004363 ABC transporter signature motif; other site 512566004364 Walker B; other site 512566004365 D-loop; other site 512566004366 H-loop/switch region; other site 512566004367 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512566004368 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512566004369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566004370 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512566004371 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512566004372 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 512566004373 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 512566004374 peptide binding site [polypeptide binding]; other site 512566004375 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 512566004376 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 512566004377 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 512566004378 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 512566004379 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 512566004380 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 512566004381 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 512566004382 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 512566004383 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 512566004384 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 512566004385 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 512566004386 DHH family; Region: DHH; pfam01368 512566004387 DHHA2 domain; Region: DHHA2; pfam02833 512566004388 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 512566004389 GIY-YIG motif/motif A; other site 512566004390 putative active site [active] 512566004391 putative metal binding site [ion binding]; other site 512566004392 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 512566004393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566004394 S-adenosylmethionine binding site [chemical binding]; other site 512566004395 hypothetical protein; Provisional; Region: PRK07252 512566004396 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 512566004397 RNA binding site [nucleotide binding]; other site 512566004398 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566004399 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 512566004400 active site 512566004401 motif I; other site 512566004402 motif II; other site 512566004403 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566004404 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 512566004405 active site 512566004406 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 512566004407 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 512566004408 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 512566004409 dimer interface [polypeptide binding]; other site 512566004410 ssDNA binding site [nucleotide binding]; other site 512566004411 tetramer (dimer of dimers) interface [polypeptide binding]; other site 512566004412 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 512566004413 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 512566004414 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 512566004415 putative dimer interface [polypeptide binding]; other site 512566004416 putative anticodon binding site; other site 512566004417 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 512566004418 homodimer interface [polypeptide binding]; other site 512566004419 motif 1; other site 512566004420 motif 2; other site 512566004421 active site 512566004422 motif 3; other site 512566004423 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 512566004424 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 512566004425 aspartate aminotransferase; Provisional; Region: PRK05764 512566004426 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512566004427 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512566004428 homodimer interface [polypeptide binding]; other site 512566004429 catalytic residue [active] 512566004430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 512566004431 Predicted flavoprotein [General function prediction only]; Region: COG0431 512566004432 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 512566004433 hypothetical protein; Validated; Region: PRK02101 512566004434 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 512566004435 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 512566004436 active site 512566004437 catalytic residues [active] 512566004438 metal binding site [ion binding]; metal-binding site 512566004439 putative S-transferase; Provisional; Region: PRK11752 512566004440 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 512566004441 C-terminal domain interface [polypeptide binding]; other site 512566004442 GSH binding site (G-site) [chemical binding]; other site 512566004443 dimer interface [polypeptide binding]; other site 512566004444 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 512566004445 N-terminal domain interface [polypeptide binding]; other site 512566004446 dimer interface [polypeptide binding]; other site 512566004447 substrate binding pocket (H-site) [chemical binding]; other site 512566004448 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 512566004449 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 512566004450 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 512566004451 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 512566004452 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 512566004453 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 512566004454 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 512566004455 Cation efflux family; Region: Cation_efflux; pfam01545 512566004456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 512566004457 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 512566004458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566004459 Walker A/P-loop; other site 512566004460 ATP binding site [chemical binding]; other site 512566004461 Q-loop/lid; other site 512566004462 ABC transporter signature motif; other site 512566004463 Walker B; other site 512566004464 D-loop; other site 512566004465 H-loop/switch region; other site 512566004466 ABC transporter; Region: ABC_tran_2; pfam12848 512566004467 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512566004468 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 512566004469 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 512566004470 active site 512566004471 NTP binding site [chemical binding]; other site 512566004472 metal binding triad [ion binding]; metal-binding site 512566004473 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 512566004474 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 512566004475 dihydrodipicolinate reductase; Provisional; Region: PRK00048 512566004476 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 512566004477 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 512566004478 EDD domain protein, DegV family; Region: DegV; TIGR00762 512566004479 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 512566004480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 512566004481 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 512566004482 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 512566004483 active site 512566004484 substrate binding site [chemical binding]; other site 512566004485 metal binding site [ion binding]; metal-binding site 512566004486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 512566004487 YbbR-like protein; Region: YbbR; pfam07949 512566004488 Uncharacterized conserved protein [Function unknown]; Region: COG1624 512566004489 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 512566004490 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 512566004491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512566004492 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512566004493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 512566004494 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 512566004495 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 512566004496 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 512566004497 dimer interface [polypeptide binding]; other site 512566004498 phosphate binding site [ion binding]; other site 512566004499 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 512566004500 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 512566004501 homotrimer interaction site [polypeptide binding]; other site 512566004502 putative active site [active] 512566004503 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 512566004504 G1 box; other site 512566004505 GTP/Mg2+ binding site [chemical binding]; other site 512566004506 Switch I region; other site 512566004507 G2 box; other site 512566004508 G3 box; other site 512566004509 Switch II region; other site 512566004510 G4 box; other site 512566004511 G5 box; other site 512566004512 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 512566004513 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 512566004514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512566004515 Walker A motif; other site 512566004516 ATP binding site [chemical binding]; other site 512566004517 Walker B motif; other site 512566004518 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 512566004519 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 512566004520 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 512566004521 folate binding site [chemical binding]; other site 512566004522 NADP+ binding site [chemical binding]; other site 512566004523 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 512566004524 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 512566004525 dimerization interface [polypeptide binding]; other site 512566004526 DPS ferroxidase diiron center [ion binding]; other site 512566004527 ion pore; other site 512566004528 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 512566004529 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 512566004530 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 512566004531 active site 512566004532 triosephosphate isomerase; Provisional; Region: PRK14567 512566004533 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 512566004534 substrate binding site [chemical binding]; other site 512566004535 dimer interface [polypeptide binding]; other site 512566004536 catalytic triad [active] 512566004537 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 512566004538 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 512566004539 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 512566004540 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 512566004541 proposed active site lysine [active] 512566004542 conserved cys residue [active] 512566004543 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512566004544 active site 512566004545 Methyltransferase domain; Region: Methyltransf_31; pfam13847 512566004546 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566004547 S-adenosylmethionine binding site [chemical binding]; other site 512566004548 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 512566004549 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 512566004550 Walker A/P-loop; other site 512566004551 ATP binding site [chemical binding]; other site 512566004552 Q-loop/lid; other site 512566004553 ABC transporter signature motif; other site 512566004554 Walker B; other site 512566004555 D-loop; other site 512566004556 H-loop/switch region; other site 512566004557 TOBE domain; Region: TOBE_2; pfam08402 512566004558 Isochorismatase family; Region: Isochorismatase; pfam00857 512566004559 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 512566004560 catalytic triad [active] 512566004561 conserved cis-peptide bond; other site 512566004562 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 512566004563 CodY GAF-like domain; Region: CodY; pfam06018 512566004564 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512566004565 putative DNA binding site [nucleotide binding]; other site 512566004566 putative Zn2+ binding site [ion binding]; other site 512566004567 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 512566004568 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 512566004569 ATP binding site [chemical binding]; other site 512566004570 Mg++ binding site [ion binding]; other site 512566004571 motif III; other site 512566004572 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512566004573 nucleotide binding region [chemical binding]; other site 512566004574 ATP-binding site [chemical binding]; other site 512566004575 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 512566004576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512566004577 putative substrate translocation pore; other site 512566004578 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 512566004579 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 512566004580 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512566004581 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 512566004582 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 512566004583 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 512566004584 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 512566004585 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 512566004586 catalytic triad [active] 512566004587 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 512566004588 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 512566004589 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 512566004590 active site 512566004591 putative transposase OrfB; Reviewed; Region: PHA02517 512566004592 HTH-like domain; Region: HTH_21; pfam13276 512566004593 Integrase core domain; Region: rve; pfam00665 512566004594 Integrase core domain; Region: rve_2; pfam13333 512566004595 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 512566004596 Helix-turn-helix domain; Region: HTH_28; pfam13518 512566004597 Predicted membrane protein [Function unknown]; Region: COG4720 512566004598 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 512566004599 dimer interface [polypeptide binding]; other site 512566004600 substrate binding site [chemical binding]; other site 512566004601 ATP binding site [chemical binding]; other site 512566004602 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 512566004603 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 512566004604 dimerization interface 3.5A [polypeptide binding]; other site 512566004605 active site 512566004606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512566004607 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 512566004608 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 512566004609 PhnA protein; Region: PhnA; pfam03831 512566004610 cytidylate kinase; Provisional; Region: cmk; PRK00023 512566004611 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 512566004612 CMP-binding site; other site 512566004613 The sites determining sugar specificity; other site 512566004614 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 512566004615 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 512566004616 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 512566004617 Ligand binding site; other site 512566004618 Putative Catalytic site; other site 512566004619 DXD motif; other site 512566004620 UDP-glucose 4-epimerase; Region: PLN02240 512566004621 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 512566004622 NAD binding site [chemical binding]; other site 512566004623 homodimer interface [polypeptide binding]; other site 512566004624 active site 512566004625 substrate binding site [chemical binding]; other site 512566004626 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 512566004627 Uncharacterized conserved protein [Function unknown]; Region: COG0327 512566004628 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 512566004629 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 512566004630 Family of unknown function (DUF633); Region: DUF633; pfam04816 512566004631 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 512566004632 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 512566004633 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 512566004634 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566004635 motif II; other site 512566004636 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 512566004637 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 512566004638 putative acyl-acceptor binding pocket; other site 512566004639 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 512566004640 Cadmium resistance transporter; Region: Cad; pfam03596 512566004641 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 512566004642 16S/18S rRNA binding site [nucleotide binding]; other site 512566004643 S13e-L30e interaction site [polypeptide binding]; other site 512566004644 25S rRNA binding site [nucleotide binding]; other site 512566004645 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 512566004646 NADH(P)-binding; Region: NAD_binding_10; pfam13460 512566004647 NAD binding site [chemical binding]; other site 512566004648 substrate binding site [chemical binding]; other site 512566004649 putative active site [active] 512566004650 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 512566004651 metal binding site [ion binding]; metal-binding site 512566004652 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 512566004653 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 512566004654 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 512566004655 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 512566004656 active site 512566004657 dimer interface [polypeptide binding]; other site 512566004658 motif 1; other site 512566004659 motif 2; other site 512566004660 motif 3; other site 512566004661 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 512566004662 anticodon binding site; other site 512566004663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512566004664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566004665 ATP binding site [chemical binding]; other site 512566004666 Mg2+ binding site [ion binding]; other site 512566004667 G-X-G motif; other site 512566004668 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512566004669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512566004670 active site 512566004671 phosphorylation site [posttranslational modification] 512566004672 intermolecular recognition site; other site 512566004673 dimerization interface [polypeptide binding]; other site 512566004674 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512566004675 DNA binding site [nucleotide binding] 512566004676 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 512566004677 nucleophilic elbow; other site 512566004678 catalytic triad; other site 512566004679 Predicted transcriptional regulator [Transcription]; Region: COG1959 512566004680 Transcriptional regulator; Region: Rrf2; pfam02082 512566004681 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 512566004682 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 512566004683 active site 512566004684 metal binding site [ion binding]; metal-binding site 512566004685 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 512566004686 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 512566004687 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 512566004688 FeoA domain; Region: FeoA; pfam04023 512566004689 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 512566004690 putative active site [active] 512566004691 dimerization interface [polypeptide binding]; other site 512566004692 putative tRNAtyr binding site [nucleotide binding]; other site 512566004693 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 512566004694 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 512566004695 Zn2+ binding site [ion binding]; other site 512566004696 Mg2+ binding site [ion binding]; other site 512566004697 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 512566004698 synthetase active site [active] 512566004699 NTP binding site [chemical binding]; other site 512566004700 metal binding site [ion binding]; metal-binding site 512566004701 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 512566004702 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 512566004703 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 512566004704 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 512566004705 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 512566004706 active site 512566004707 Zn binding site [ion binding]; other site 512566004708 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 512566004709 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 512566004710 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 512566004711 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512566004712 ABC-ATPase subunit interface; other site 512566004713 dimer interface [polypeptide binding]; other site 512566004714 putative PBP binding regions; other site 512566004715 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 512566004716 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 512566004717 metal binding site [ion binding]; metal-binding site 512566004718 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 512566004719 dimer interface [polypeptide binding]; other site 512566004720 catalytic triad [active] 512566004721 peroxidatic and resolving cysteines [active] 512566004722 FtsX-like permease family; Region: FtsX; pfam02687 512566004723 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 512566004724 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 512566004725 FtsX-like permease family; Region: FtsX; pfam02687 512566004726 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512566004727 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512566004728 Walker A/P-loop; other site 512566004729 ATP binding site [chemical binding]; other site 512566004730 Q-loop/lid; other site 512566004731 ABC transporter signature motif; other site 512566004732 Walker B; other site 512566004733 D-loop; other site 512566004734 H-loop/switch region; other site 512566004735 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512566004736 catalytic core [active] 512566004737 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 512566004738 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 512566004739 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512566004740 active site 512566004741 HIGH motif; other site 512566004742 nucleotide binding site [chemical binding]; other site 512566004743 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 512566004744 active site 512566004745 KMSKS motif; other site 512566004746 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 512566004747 tRNA binding surface [nucleotide binding]; other site 512566004748 anticodon binding site; other site 512566004749 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 512566004750 DivIVA domain; Region: DivI1A_domain; TIGR03544 512566004751 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 512566004752 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 512566004753 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 512566004754 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512566004755 RNA binding surface [nucleotide binding]; other site 512566004756 YGGT family; Region: YGGT; pfam02325 512566004757 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 512566004758 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 512566004759 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 512566004760 catalytic residue [active] 512566004761 cell division protein FtsZ; Validated; Region: PRK09330 512566004762 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 512566004763 nucleotide binding site [chemical binding]; other site 512566004764 SulA interaction site; other site 512566004765 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 512566004766 Cell division protein FtsA; Region: FtsA; smart00842 512566004767 Cell division protein FtsA; Region: FtsA; pfam14450 512566004768 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 512566004769 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 512566004770 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 512566004771 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 512566004772 nudix motif; other site 512566004773 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 512566004774 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 512566004775 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 512566004776 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 512566004777 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 512566004778 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 512566004779 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 512566004780 recombination protein RecR; Reviewed; Region: recR; PRK00076 512566004781 RecR protein; Region: RecR; pfam02132 512566004782 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 512566004783 putative active site [active] 512566004784 putative metal-binding site [ion binding]; other site 512566004785 tetramer interface [polypeptide binding]; other site 512566004786 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 512566004787 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 512566004788 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 512566004789 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 512566004790 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 512566004791 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 512566004792 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 512566004793 putative active site [active] 512566004794 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512566004795 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512566004796 nucleotide binding site [chemical binding]; other site 512566004797 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 512566004798 Class I aldolases; Region: Aldolase_Class_I; cl17187 512566004799 catalytic residue [active] 512566004800 Protein of unknown function, DUF624; Region: DUF624; pfam04854 512566004801 Domain of unknown function (DUF386); Region: DUF386; pfam04074 512566004802 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512566004803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566004804 dimer interface [polypeptide binding]; other site 512566004805 conserved gate region; other site 512566004806 putative PBP binding loops; other site 512566004807 ABC-ATPase subunit interface; other site 512566004808 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 512566004809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512566004810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566004811 putative PBP binding loops; other site 512566004812 dimer interface [polypeptide binding]; other site 512566004813 ABC-ATPase subunit interface; other site 512566004814 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512566004815 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512566004816 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 512566004817 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 512566004818 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 512566004819 active site turn [active] 512566004820 phosphorylation site [posttranslational modification] 512566004821 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 512566004822 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 512566004823 putative active site cavity [active] 512566004824 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 512566004825 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 512566004826 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 512566004827 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 512566004828 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 512566004829 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 512566004830 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 512566004831 Asp-box motif; other site 512566004832 catalytic site [active] 512566004833 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512566004834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566004835 dimer interface [polypeptide binding]; other site 512566004836 conserved gate region; other site 512566004837 putative PBP binding loops; other site 512566004838 ABC-ATPase subunit interface; other site 512566004839 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 512566004840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566004841 dimer interface [polypeptide binding]; other site 512566004842 conserved gate region; other site 512566004843 putative PBP binding loops; other site 512566004844 ABC-ATPase subunit interface; other site 512566004845 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512566004846 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512566004847 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 512566004848 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 512566004849 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 512566004850 catalytic site [active] 512566004851 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 512566004852 Asp-box motif; other site 512566004853 Asp-box motif; other site 512566004854 catalytic site [active] 512566004855 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 512566004856 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 512566004857 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 512566004858 ssDNA binding site; other site 512566004859 generic binding surface II; other site 512566004860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512566004861 ATP binding site [chemical binding]; other site 512566004862 putative Mg++ binding site [ion binding]; other site 512566004863 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512566004864 nucleotide binding region [chemical binding]; other site 512566004865 ATP-binding site [chemical binding]; other site 512566004866 alanine racemase; Reviewed; Region: alr; PRK00053 512566004867 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 512566004868 active site 512566004869 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 512566004870 dimer interface [polypeptide binding]; other site 512566004871 substrate binding site [chemical binding]; other site 512566004872 catalytic residues [active] 512566004873 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 512566004874 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 512566004875 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 512566004876 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 512566004877 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 512566004878 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 512566004879 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 512566004880 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512566004881 nucleotide binding region [chemical binding]; other site 512566004882 ATP-binding site [chemical binding]; other site 512566004883 SEC-C motif; Region: SEC-C; pfam02810 512566004884 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 512566004885 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512566004886 Walker A/P-loop; other site 512566004887 ATP binding site [chemical binding]; other site 512566004888 Q-loop/lid; other site 512566004889 ABC transporter signature motif; other site 512566004890 Walker B; other site 512566004891 D-loop; other site 512566004892 H-loop/switch region; other site 512566004893 GTP-binding protein Der; Reviewed; Region: PRK00093 512566004894 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 512566004895 G1 box; other site 512566004896 GTP/Mg2+ binding site [chemical binding]; other site 512566004897 Switch I region; other site 512566004898 G2 box; other site 512566004899 Switch II region; other site 512566004900 G3 box; other site 512566004901 G4 box; other site 512566004902 G5 box; other site 512566004903 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 512566004904 G1 box; other site 512566004905 GTP/Mg2+ binding site [chemical binding]; other site 512566004906 Switch I region; other site 512566004907 G2 box; other site 512566004908 G3 box; other site 512566004909 Switch II region; other site 512566004910 G4 box; other site 512566004911 G5 box; other site 512566004912 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 512566004913 dimer interface [polypeptide binding]; other site 512566004914 FMN binding site [chemical binding]; other site 512566004915 NADPH bind site [chemical binding]; other site 512566004916 primosomal protein DnaI; Reviewed; Region: PRK08939 512566004917 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 512566004918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512566004919 Walker A motif; other site 512566004920 ATP binding site [chemical binding]; other site 512566004921 Walker B motif; other site 512566004922 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 512566004923 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 512566004924 ATP cone domain; Region: ATP-cone; pfam03477 512566004925 Predicted transcriptional regulators [Transcription]; Region: COG1725 512566004926 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512566004927 DNA-binding site [nucleotide binding]; DNA binding site 512566004928 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 512566004929 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512566004930 Walker A/P-loop; other site 512566004931 ATP binding site [chemical binding]; other site 512566004932 Q-loop/lid; other site 512566004933 ABC transporter signature motif; other site 512566004934 Walker B; other site 512566004935 D-loop; other site 512566004936 H-loop/switch region; other site 512566004937 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 512566004938 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 512566004939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566004940 Walker A/P-loop; other site 512566004941 ATP binding site [chemical binding]; other site 512566004942 Q-loop/lid; other site 512566004943 ABC transporter signature motif; other site 512566004944 Walker B; other site 512566004945 D-loop; other site 512566004946 H-loop/switch region; other site 512566004947 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 512566004948 Uncharacterized conserved protein [Function unknown]; Region: COG0398 512566004949 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 512566004950 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512566004951 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512566004952 nucleotide binding site [chemical binding]; other site 512566004953 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 512566004954 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 512566004955 active site turn [active] 512566004956 phosphorylation site [posttranslational modification] 512566004957 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 512566004958 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 512566004959 HPr interaction site; other site 512566004960 glycerol kinase (GK) interaction site [polypeptide binding]; other site 512566004961 active site 512566004962 phosphorylation site [posttranslational modification] 512566004963 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 512566004964 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 512566004965 substrate binding [chemical binding]; other site 512566004966 active site 512566004967 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 512566004968 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512566004969 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512566004970 DNA binding site [nucleotide binding] 512566004971 domain linker motif; other site 512566004972 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 512566004973 dimerization interface [polypeptide binding]; other site 512566004974 ligand binding site [chemical binding]; other site 512566004975 sodium binding site [ion binding]; other site 512566004976 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 512566004977 homodimer interface [polypeptide binding]; other site 512566004978 catalytic residues [active] 512566004979 NAD binding site [chemical binding]; other site 512566004980 substrate binding pocket [chemical binding]; other site 512566004981 flexible flap; other site 512566004982 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 512566004983 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 512566004984 dimer interface [polypeptide binding]; other site 512566004985 active site 512566004986 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 512566004987 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 512566004988 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 512566004989 Uncharacterized conserved protein [Function unknown]; Region: COG3610 512566004990 Uncharacterized conserved protein [Function unknown]; Region: COG2966 512566004991 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 512566004992 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512566004993 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 512566004994 substrate binding site [chemical binding]; other site 512566004995 activation loop (A-loop); other site 512566004996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 512566004997 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 512566004998 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 512566004999 PASTA domain; Region: PASTA; smart00740 512566005000 PASTA domain; Region: PASTA; smart00740 512566005001 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 512566005002 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 512566005003 ATP binding site [chemical binding]; other site 512566005004 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 512566005005 active site 512566005006 16S rRNA methyltransferase B; Provisional; Region: PRK14902 512566005007 NusB family; Region: NusB; pfam01029 512566005008 putative RNA binding site [nucleotide binding]; other site 512566005009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566005010 S-adenosylmethionine binding site [chemical binding]; other site 512566005011 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 512566005012 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 512566005013 putative active site [active] 512566005014 substrate binding site [chemical binding]; other site 512566005015 putative cosubstrate binding site; other site 512566005016 catalytic site [active] 512566005017 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 512566005018 substrate binding site [chemical binding]; other site 512566005019 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 512566005020 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512566005021 ATP binding site [chemical binding]; other site 512566005022 putative Mg++ binding site [ion binding]; other site 512566005023 helicase superfamily c-terminal domain; Region: HELICc; smart00490 512566005024 ATP-binding site [chemical binding]; other site 512566005025 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 512566005026 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 512566005027 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 512566005028 catalytic site [active] 512566005029 G-X2-G-X-G-K; other site 512566005030 hypothetical protein; Provisional; Region: PRK00106 512566005031 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 512566005032 Zn2+ binding site [ion binding]; other site 512566005033 Mg2+ binding site [ion binding]; other site 512566005034 SIR2-like domain; Region: SIR2_2; pfam13289 512566005035 hypothetical protein; Provisional; Region: PRK13670 512566005036 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 512566005037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566005038 S-adenosylmethionine binding site [chemical binding]; other site 512566005039 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 512566005040 Isochorismatase family; Region: Isochorismatase; pfam00857 512566005041 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 512566005042 catalytic triad [active] 512566005043 conserved cis-peptide bond; other site 512566005044 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 512566005045 Zn2+ binding site [ion binding]; other site 512566005046 Mg2+ binding site [ion binding]; other site 512566005047 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 512566005048 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 512566005049 active site 512566005050 (T/H)XGH motif; other site 512566005051 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 512566005052 GTPase YqeH; Provisional; Region: PRK13796 512566005053 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 512566005054 GTP/Mg2+ binding site [chemical binding]; other site 512566005055 G4 box; other site 512566005056 G5 box; other site 512566005057 G1 box; other site 512566005058 Switch I region; other site 512566005059 G2 box; other site 512566005060 G3 box; other site 512566005061 Switch II region; other site 512566005062 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 512566005063 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566005064 active site 512566005065 motif I; other site 512566005066 motif II; other site 512566005067 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 512566005068 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 512566005069 Cl binding site [ion binding]; other site 512566005070 oligomer interface [polypeptide binding]; other site 512566005071 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 512566005072 Mechanosensitive ion channel; Region: MS_channel; pfam00924 512566005073 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 512566005074 serine/threonine transporter SstT; Provisional; Region: PRK14695 512566005075 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 512566005076 Predicted membrane protein [Function unknown]; Region: COG4129 512566005077 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 512566005078 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 512566005079 MarR family; Region: MarR; pfam01047 512566005080 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 512566005081 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 512566005082 catalytic residues [active] 512566005083 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 512566005084 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 512566005085 amphipathic channel; other site 512566005086 Asn-Pro-Ala signature motifs; other site 512566005087 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 512566005088 oligoendopeptidase F; Region: pepF; TIGR00181 512566005089 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 512566005090 Zn binding site [ion binding]; other site 512566005091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 512566005092 RNA methyltransferase, RsmE family; Region: TIGR00046 512566005093 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 512566005094 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 512566005095 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566005096 S-adenosylmethionine binding site [chemical binding]; other site 512566005097 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 512566005098 nudix motif; other site 512566005099 Peptidase family M50; Region: Peptidase_M50; pfam02163 512566005100 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 512566005101 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 512566005102 YcfA-like protein; Region: YcfA; pfam07927 512566005103 recombination factor protein RarA; Reviewed; Region: PRK13342 512566005104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512566005105 Walker A motif; other site 512566005106 ATP binding site [chemical binding]; other site 512566005107 Walker B motif; other site 512566005108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 512566005109 arginine finger; other site 512566005110 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 512566005111 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 512566005112 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 512566005113 substrate binding [chemical binding]; other site 512566005114 active site 512566005115 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 512566005116 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512566005117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566005118 dimer interface [polypeptide binding]; other site 512566005119 conserved gate region; other site 512566005120 putative PBP binding loops; other site 512566005121 ABC-ATPase subunit interface; other site 512566005122 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 512566005123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566005124 dimer interface [polypeptide binding]; other site 512566005125 conserved gate region; other site 512566005126 putative PBP binding loops; other site 512566005127 ABC-ATPase subunit interface; other site 512566005128 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512566005129 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512566005130 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512566005131 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512566005132 DNA binding site [nucleotide binding] 512566005133 domain linker motif; other site 512566005134 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 512566005135 dimerization interface [polypeptide binding]; other site 512566005136 ligand binding site [chemical binding]; other site 512566005137 sodium binding site [ion binding]; other site 512566005138 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 512566005139 Mga helix-turn-helix domain; Region: Mga; pfam05043 512566005140 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 512566005141 Predicted membrane protein [Function unknown]; Region: COG2261 512566005142 Small integral membrane protein [Function unknown]; Region: COG5547 512566005143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 512566005144 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 512566005145 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 512566005146 Uncharacterized conserved protein [Function unknown]; Region: COG1262 512566005147 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 512566005148 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 512566005149 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 512566005150 active site 512566005151 methionine cluster; other site 512566005152 phosphorylation site [posttranslational modification] 512566005153 metal binding site [ion binding]; metal-binding site 512566005154 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 512566005155 active site 512566005156 P-loop; other site 512566005157 phosphorylation site [posttranslational modification] 512566005158 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512566005159 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 512566005160 MarR family; Region: MarR_2; pfam12802 512566005161 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512566005162 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 512566005163 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 512566005164 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512566005165 Coenzyme A binding pocket [chemical binding]; other site 512566005166 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 512566005167 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 512566005168 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 512566005169 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512566005170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566005171 non-specific DNA binding site [nucleotide binding]; other site 512566005172 salt bridge; other site 512566005173 sequence-specific DNA binding site [nucleotide binding]; other site 512566005174 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 512566005175 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 512566005176 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 512566005177 substrate binding site [chemical binding]; other site 512566005178 active site 512566005179 catalytic residues [active] 512566005180 heterodimer interface [polypeptide binding]; other site 512566005181 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 512566005182 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 512566005183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512566005184 catalytic residue [active] 512566005185 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 512566005186 active site 512566005187 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 512566005188 active site 512566005189 ribulose/triose binding site [chemical binding]; other site 512566005190 phosphate binding site [ion binding]; other site 512566005191 substrate (anthranilate) binding pocket [chemical binding]; other site 512566005192 product (indole) binding pocket [chemical binding]; other site 512566005193 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 512566005194 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 512566005195 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 512566005196 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 512566005197 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 512566005198 glutamine binding [chemical binding]; other site 512566005199 catalytic triad [active] 512566005200 anthranilate synthase component I; Provisional; Region: PRK13570 512566005201 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 512566005202 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 512566005203 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512566005204 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512566005205 DNA binding site [nucleotide binding] 512566005206 domain linker motif; other site 512566005207 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 512566005208 putative dimerization interface [polypeptide binding]; other site 512566005209 putative ligand binding site [chemical binding]; other site 512566005210 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 512566005211 MgtC family; Region: MgtC; pfam02308 512566005212 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 512566005213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566005214 dimer interface [polypeptide binding]; other site 512566005215 conserved gate region; other site 512566005216 putative PBP binding loops; other site 512566005217 ABC-ATPase subunit interface; other site 512566005218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566005219 putative PBP binding loops; other site 512566005220 dimer interface [polypeptide binding]; other site 512566005221 ABC-ATPase subunit interface; other site 512566005222 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 512566005223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566005224 Walker A/P-loop; other site 512566005225 ATP binding site [chemical binding]; other site 512566005226 Q-loop/lid; other site 512566005227 ABC transporter signature motif; other site 512566005228 Walker B; other site 512566005229 D-loop; other site 512566005230 H-loop/switch region; other site 512566005231 TOBE domain; Region: TOBE; pfam03459 512566005232 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 512566005233 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 512566005234 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 512566005235 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 512566005236 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 512566005237 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 512566005238 Pectate lyase; Region: Pec_lyase_C; cl01593 512566005239 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 512566005240 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 512566005241 inhibitor-cofactor binding pocket; inhibition site 512566005242 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512566005243 catalytic residue [active] 512566005244 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 512566005245 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512566005246 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512566005247 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 512566005248 Walker A/P-loop; other site 512566005249 ATP binding site [chemical binding]; other site 512566005250 Q-loop/lid; other site 512566005251 ABC transporter signature motif; other site 512566005252 Walker B; other site 512566005253 D-loop; other site 512566005254 H-loop/switch region; other site 512566005255 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512566005256 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 512566005257 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566005258 Walker A/P-loop; other site 512566005259 ATP binding site [chemical binding]; other site 512566005260 Q-loop/lid; other site 512566005261 ABC transporter signature motif; other site 512566005262 Walker B; other site 512566005263 D-loop; other site 512566005264 H-loop/switch region; other site 512566005265 Predicted membrane protein [Function unknown]; Region: COG2323 512566005266 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 512566005267 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 512566005268 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 512566005269 active site 512566005270 putative catalytic site [active] 512566005271 DNA binding site [nucleotide binding] 512566005272 putative phosphate binding site [ion binding]; other site 512566005273 metal binding site A [ion binding]; metal-binding site 512566005274 AP binding site [nucleotide binding]; other site 512566005275 metal binding site B [ion binding]; metal-binding site 512566005276 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 512566005277 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 512566005278 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512566005279 active site 512566005280 xanthine permease; Region: pbuX; TIGR03173 512566005281 Sulfate transporter family; Region: Sulfate_transp; pfam00916 512566005282 DpnII restriction endonuclease; Region: DpnII; pfam04556 512566005283 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 512566005284 DNA methylase; Region: N6_N4_Mtase; pfam01555 512566005285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566005286 S-adenosylmethionine binding site [chemical binding]; other site 512566005287 DNA adenine methylase (dam); Region: dam; TIGR00571 512566005288 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 512566005289 CoenzymeA binding site [chemical binding]; other site 512566005290 subunit interaction site [polypeptide binding]; other site 512566005291 PHB binding site; other site 512566005292 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 512566005293 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 512566005294 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 512566005295 galactokinase; Provisional; Region: PRK05322 512566005296 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 512566005297 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 512566005298 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 512566005299 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 512566005300 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512566005301 DNA binding site [nucleotide binding] 512566005302 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 512566005303 putative dimerization interface [polypeptide binding]; other site 512566005304 putative ligand binding site [chemical binding]; other site 512566005305 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 512566005306 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 512566005307 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 512566005308 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 512566005309 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 512566005310 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 512566005311 DNA binding residues [nucleotide binding] 512566005312 putative dimer interface [polypeptide binding]; other site 512566005313 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 512566005314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512566005315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512566005316 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 512566005317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566005318 dimer interface [polypeptide binding]; other site 512566005319 conserved gate region; other site 512566005320 ABC-ATPase subunit interface; other site 512566005321 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 512566005322 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 512566005323 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 512566005324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566005325 Walker A/P-loop; other site 512566005326 ATP binding site [chemical binding]; other site 512566005327 Q-loop/lid; other site 512566005328 ABC transporter signature motif; other site 512566005329 Walker B; other site 512566005330 D-loop; other site 512566005331 H-loop/switch region; other site 512566005332 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 512566005333 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 512566005334 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 512566005335 Enterocin A Immunity; Region: EntA_Immun; pfam08951 512566005336 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 512566005337 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 512566005338 oligomer interface [polypeptide binding]; other site 512566005339 active site 512566005340 metal binding site [ion binding]; metal-binding site 512566005341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512566005342 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 512566005343 NAD(P) binding site [chemical binding]; other site 512566005344 active site 512566005345 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 512566005346 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512566005347 ABC-ATPase subunit interface; other site 512566005348 dimer interface [polypeptide binding]; other site 512566005349 putative PBP binding regions; other site 512566005350 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512566005351 ABC-ATPase subunit interface; other site 512566005352 dimer interface [polypeptide binding]; other site 512566005353 putative PBP binding regions; other site 512566005354 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 512566005355 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 512566005356 Walker A/P-loop; other site 512566005357 ATP binding site [chemical binding]; other site 512566005358 Q-loop/lid; other site 512566005359 ABC transporter signature motif; other site 512566005360 Walker B; other site 512566005361 D-loop; other site 512566005362 H-loop/switch region; other site 512566005363 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 512566005364 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 512566005365 putative ligand binding residues [chemical binding]; other site 512566005366 hypothetical protein; Validated; Region: PRK00041 512566005367 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 512566005368 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512566005369 RNA binding surface [nucleotide binding]; other site 512566005370 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 512566005371 active site 512566005372 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 512566005373 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 512566005374 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 512566005375 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 512566005376 DNA binding site [nucleotide binding] 512566005377 Int/Topo IB signature motif; other site 512566005378 active site 512566005379 catalytic residues [active] 512566005380 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 512566005381 FOG: CBS domain [General function prediction only]; Region: COG0517 512566005382 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 512566005383 active site 512566005384 metal binding site [ion binding]; metal-binding site 512566005385 homotetramer interface [polypeptide binding]; other site 512566005386 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 512566005387 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 512566005388 active site 512566005389 dimerization interface [polypeptide binding]; other site 512566005390 glutamate racemase; Provisional; Region: PRK00865 512566005391 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 512566005392 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 512566005393 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 512566005394 Ca binding site [ion binding]; other site 512566005395 active site 512566005396 catalytic site [active] 512566005397 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 512566005398 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 512566005399 active site turn [active] 512566005400 phosphorylation site [posttranslational modification] 512566005401 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 512566005402 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 512566005403 HPr interaction site; other site 512566005404 glycerol kinase (GK) interaction site [polypeptide binding]; other site 512566005405 active site 512566005406 phosphorylation site [posttranslational modification] 512566005407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512566005408 DNA-binding site [nucleotide binding]; DNA binding site 512566005409 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 512566005410 UTRA domain; Region: UTRA; pfam07702 512566005411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 512566005412 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 512566005413 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 512566005414 Transposase; Region: DDE_Tnp_ISL3; pfam01610 512566005415 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 512566005416 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512566005417 Walker A/P-loop; other site 512566005418 ATP binding site [chemical binding]; other site 512566005419 Q-loop/lid; other site 512566005420 ABC transporter signature motif; other site 512566005421 Walker B; other site 512566005422 D-loop; other site 512566005423 H-loop/switch region; other site 512566005424 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 512566005425 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 512566005426 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512566005427 Walker A/P-loop; other site 512566005428 ATP binding site [chemical binding]; other site 512566005429 Q-loop/lid; other site 512566005430 ABC transporter signature motif; other site 512566005431 Walker B; other site 512566005432 D-loop; other site 512566005433 H-loop/switch region; other site 512566005434 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512566005435 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 512566005436 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 512566005437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566005438 dimer interface [polypeptide binding]; other site 512566005439 conserved gate region; other site 512566005440 putative PBP binding loops; other site 512566005441 ABC-ATPase subunit interface; other site 512566005442 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 512566005443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566005444 dimer interface [polypeptide binding]; other site 512566005445 conserved gate region; other site 512566005446 putative PBP binding loops; other site 512566005447 ABC-ATPase subunit interface; other site 512566005448 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 512566005449 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 512566005450 peptide binding site [polypeptide binding]; other site 512566005451 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 512566005452 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 512566005453 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 512566005454 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 512566005455 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 512566005456 active site 512566005457 homodimer interface [polypeptide binding]; other site 512566005458 catalytic site [active] 512566005459 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512566005460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566005461 dimer interface [polypeptide binding]; other site 512566005462 conserved gate region; other site 512566005463 putative PBP binding loops; other site 512566005464 ABC-ATPase subunit interface; other site 512566005465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566005466 dimer interface [polypeptide binding]; other site 512566005467 conserved gate region; other site 512566005468 putative PBP binding loops; other site 512566005469 ABC-ATPase subunit interface; other site 512566005470 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512566005471 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512566005472 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 512566005473 Melibiase; Region: Melibiase; pfam02065 512566005474 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 512566005475 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512566005476 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 512566005477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 512566005478 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 512566005479 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512566005480 DNA-binding site [nucleotide binding]; DNA binding site 512566005481 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 512566005482 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 512566005483 TRAM domain; Region: TRAM; pfam01938 512566005484 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 512566005485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566005486 S-adenosylmethionine binding site [chemical binding]; other site 512566005487 recombination regulator RecX; Provisional; Region: recX; PRK14135 512566005488 hypothetical protein; Provisional; Region: PRK13662 512566005489 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 512566005490 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566005491 non-specific DNA binding site [nucleotide binding]; other site 512566005492 salt bridge; other site 512566005493 sequence-specific DNA binding site [nucleotide binding]; other site 512566005494 Methyltransferase domain; Region: Methyltransf_31; pfam13847 512566005495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566005496 S-adenosylmethionine binding site [chemical binding]; other site 512566005497 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 512566005498 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 512566005499 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 512566005500 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 512566005501 ring oligomerisation interface [polypeptide binding]; other site 512566005502 ATP/Mg binding site [chemical binding]; other site 512566005503 stacking interactions; other site 512566005504 hinge regions; other site 512566005505 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 512566005506 oligomerisation interface [polypeptide binding]; other site 512566005507 mobile loop; other site 512566005508 roof hairpin; other site 512566005509 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 512566005510 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 512566005511 dimer interface [polypeptide binding]; other site 512566005512 ssDNA binding site [nucleotide binding]; other site 512566005513 tetramer (dimer of dimers) interface [polypeptide binding]; other site 512566005514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 512566005515 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 512566005516 NAD(P) binding site [chemical binding]; other site 512566005517 active site 512566005518 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 512566005519 putative tRNA-binding site [nucleotide binding]; other site 512566005520 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 512566005521 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 512566005522 catalytic residues [active] 512566005523 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 512566005524 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 512566005525 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 512566005526 LytTr DNA-binding domain; Region: LytTR; pfam04397 512566005527 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 512566005528 active site 512566005529 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 512566005530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4898 512566005531 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 512566005532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566005533 Walker A/P-loop; other site 512566005534 ATP binding site [chemical binding]; other site 512566005535 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 512566005536 Walker A/P-loop; other site 512566005537 ATP binding site [chemical binding]; other site 512566005538 Q-loop/lid; other site 512566005539 ABC transporter signature motif; other site 512566005540 Walker B; other site 512566005541 D-loop; other site 512566005542 H-loop/switch region; other site 512566005543 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512566005544 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512566005545 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512566005546 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512566005547 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 512566005548 hypothetical protein; Provisional; Region: PRK12378 512566005549 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 512566005550 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 512566005551 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 512566005552 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 512566005553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 512566005554 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 512566005555 Domain of unknown function (DUF955); Region: DUF955; cl01076 512566005556 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512566005557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566005558 non-specific DNA binding site [nucleotide binding]; other site 512566005559 salt bridge; other site 512566005560 sequence-specific DNA binding site [nucleotide binding]; other site 512566005561 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 512566005562 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 512566005563 amidase catalytic site [active] 512566005564 Zn binding residues [ion binding]; other site 512566005565 substrate binding site [chemical binding]; other site 512566005566 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566005567 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566005568 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 512566005569 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 512566005570 recombinase A; Provisional; Region: recA; PRK09354 512566005571 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 512566005572 hexamer interface [polypeptide binding]; other site 512566005573 Walker A motif; other site 512566005574 ATP binding site [chemical binding]; other site 512566005575 Walker B motif; other site 512566005576 competence damage-inducible protein A; Provisional; Region: PRK00549 512566005577 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 512566005578 putative MPT binding site; other site 512566005579 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 512566005580 Transcriptional regulator [Transcription]; Region: LytR; COG1316 512566005581 putative acetyltransferase YhhY; Provisional; Region: PRK10140 512566005582 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 512566005583 Coenzyme A binding pocket [chemical binding]; other site 512566005584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 512566005585 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 512566005586 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512566005587 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566005588 non-specific DNA binding site [nucleotide binding]; other site 512566005589 salt bridge; other site 512566005590 sequence-specific DNA binding site [nucleotide binding]; other site 512566005591 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 512566005592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 512566005593 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 512566005594 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512566005595 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 512566005596 Walker A/P-loop; other site 512566005597 ATP binding site [chemical binding]; other site 512566005598 Q-loop/lid; other site 512566005599 ABC transporter signature motif; other site 512566005600 Walker B; other site 512566005601 D-loop; other site 512566005602 H-loop/switch region; other site 512566005603 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 512566005604 active site 512566005605 multimer interface [polypeptide binding]; other site 512566005606 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 512566005607 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 512566005608 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 512566005609 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 512566005610 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 512566005611 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 512566005612 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 512566005613 G-loop; other site 512566005614 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 512566005615 DNA binding site [nucleotide binding] 512566005616 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 512566005617 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 512566005618 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 512566005619 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 512566005620 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 512566005621 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 512566005622 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 512566005623 RPB1 interaction site [polypeptide binding]; other site 512566005624 RPB10 interaction site [polypeptide binding]; other site 512566005625 RPB11 interaction site [polypeptide binding]; other site 512566005626 RPB3 interaction site [polypeptide binding]; other site 512566005627 RPB12 interaction site [polypeptide binding]; other site 512566005628 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 512566005629 Domain of unknown function DUF21; Region: DUF21; pfam01595 512566005630 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 512566005631 Transporter associated domain; Region: CorC_HlyC; smart01091 512566005632 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 512566005633 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 512566005634 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 512566005635 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 512566005636 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 512566005637 hinge; other site 512566005638 active site 512566005639 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 512566005640 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 512566005641 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 512566005642 protein binding site [polypeptide binding]; other site 512566005643 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 512566005644 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 512566005645 active site 512566005646 (T/H)XGH motif; other site 512566005647 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 512566005648 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566005649 S-adenosylmethionine binding site [chemical binding]; other site 512566005650 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 512566005651 dimer interface [polypeptide binding]; other site 512566005652 active site 512566005653 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 512566005654 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 512566005655 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 512566005656 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 512566005657 acylphosphatase; Provisional; Region: PRK14434 512566005658 OxaA-like protein precursor; Provisional; Region: PRK02463 512566005659 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 512566005660 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 512566005661 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 512566005662 FeS/SAM binding site; other site 512566005663 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 512566005664 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 512566005665 active site 512566005666 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 512566005667 substrate binding site [chemical binding]; other site 512566005668 catalytic residues [active] 512566005669 dimer interface [polypeptide binding]; other site 512566005670 pur operon repressor; Provisional; Region: PRK09213 512566005671 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 512566005672 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512566005673 active site 512566005674 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 512566005675 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 512566005676 generic binding surface II; other site 512566005677 generic binding surface I; other site 512566005678 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 512566005679 Zn2+ binding site [ion binding]; other site 512566005680 Mg2+ binding site [ion binding]; other site 512566005681 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 512566005682 RmuC family; Region: RmuC; pfam02646 512566005683 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 512566005684 Thiamine pyrophosphokinase; Region: TPK; cd07995 512566005685 active site 512566005686 dimerization interface [polypeptide binding]; other site 512566005687 thiamine binding site [chemical binding]; other site 512566005688 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 512566005689 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 512566005690 substrate binding site [chemical binding]; other site 512566005691 hexamer interface [polypeptide binding]; other site 512566005692 metal binding site [ion binding]; metal-binding site 512566005693 GTPase RsgA; Reviewed; Region: PRK00098 512566005694 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 512566005695 RNA binding site [nucleotide binding]; other site 512566005696 homodimer interface [polypeptide binding]; other site 512566005697 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 512566005698 GTPase/Zn-binding domain interface [polypeptide binding]; other site 512566005699 GTP/Mg2+ binding site [chemical binding]; other site 512566005700 G4 box; other site 512566005701 G5 box; other site 512566005702 G1 box; other site 512566005703 Switch I region; other site 512566005704 G2 box; other site 512566005705 G3 box; other site 512566005706 Switch II region; other site 512566005707 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 512566005708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566005709 S-adenosylmethionine binding site [chemical binding]; other site 512566005710 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512566005711 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 512566005712 Walker A/P-loop; other site 512566005713 ATP binding site [chemical binding]; other site 512566005714 Q-loop/lid; other site 512566005715 ABC transporter signature motif; other site 512566005716 Walker B; other site 512566005717 D-loop; other site 512566005718 H-loop/switch region; other site 512566005719 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 512566005720 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 512566005721 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 512566005722 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512566005723 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566005724 non-specific DNA binding site [nucleotide binding]; other site 512566005725 salt bridge; other site 512566005726 sequence-specific DNA binding site [nucleotide binding]; other site 512566005727 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 512566005728 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 512566005729 putative active site [active] 512566005730 putative metal binding site [ion binding]; other site 512566005731 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 512566005732 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 512566005733 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 512566005734 active site 512566005735 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 512566005736 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 512566005737 aminotransferase AlaT; Validated; Region: PRK09265 512566005738 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 512566005739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512566005740 homodimer interface [polypeptide binding]; other site 512566005741 catalytic residue [active] 512566005742 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 512566005743 Ligand Binding Site [chemical binding]; other site 512566005744 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566005745 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 512566005746 active site 512566005747 motif I; other site 512566005748 motif II; other site 512566005749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566005750 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 512566005751 putative nucleotide binding site [chemical binding]; other site 512566005752 putative metal binding site [ion binding]; other site 512566005753 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 512566005754 active site 512566005755 homotetramer interface [polypeptide binding]; other site 512566005756 homodimer interface [polypeptide binding]; other site 512566005757 catabolite control protein A; Region: ccpA; TIGR01481 512566005758 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512566005759 DNA binding site [nucleotide binding] 512566005760 domain linker motif; other site 512566005761 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 512566005762 dimerization interface [polypeptide binding]; other site 512566005763 effector binding site; other site 512566005764 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 512566005765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512566005766 active site 512566005767 phosphorylation site [posttranslational modification] 512566005768 intermolecular recognition site; other site 512566005769 dimerization interface [polypeptide binding]; other site 512566005770 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 512566005771 DNA binding residues [nucleotide binding] 512566005772 dimerization interface [polypeptide binding]; other site 512566005773 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 512566005774 Histidine kinase; Region: HisKA_3; pfam07730 512566005775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566005776 Mg2+ binding site [ion binding]; other site 512566005777 G-X-G motif; other site 512566005778 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 512566005779 ABC-2 type transporter; Region: ABC2_membrane; cl17235 512566005780 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512566005781 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512566005782 Walker A/P-loop; other site 512566005783 ATP binding site [chemical binding]; other site 512566005784 Q-loop/lid; other site 512566005785 ABC transporter signature motif; other site 512566005786 Walker B; other site 512566005787 D-loop; other site 512566005788 H-loop/switch region; other site 512566005789 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512566005790 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 512566005791 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 512566005792 putative homodimer interface [polypeptide binding]; other site 512566005793 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 512566005794 heterodimer interface [polypeptide binding]; other site 512566005795 homodimer interface [polypeptide binding]; other site 512566005796 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 512566005797 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 512566005798 Transglycosylase; Region: Transgly; pfam00912 512566005799 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 512566005800 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 512566005801 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 512566005802 active site 512566005803 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 512566005804 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 512566005805 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 512566005806 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 512566005807 FtsX-like permease family; Region: FtsX; pfam02687 512566005808 Transposase; Region: HTH_Tnp_IS630; pfam01710 512566005809 Helix-turn-helix domain; Region: HTH_28; pfam13518 512566005810 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559 512566005811 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 512566005812 dimerization interface [polypeptide binding]; other site 512566005813 active site 512566005814 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 512566005815 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 512566005816 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 512566005817 Walker A/P-loop; other site 512566005818 ATP binding site [chemical binding]; other site 512566005819 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 512566005820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512566005821 DNA-binding site [nucleotide binding]; DNA binding site 512566005822 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 512566005823 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 512566005824 beta-galactosidase; Region: BGL; TIGR03356 512566005825 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 512566005826 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 512566005827 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 512566005828 active site 512566005829 P-loop; other site 512566005830 phosphorylation site [posttranslational modification] 512566005831 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 512566005832 methionine cluster; other site 512566005833 active site 512566005834 phosphorylation site [posttranslational modification] 512566005835 metal binding site [ion binding]; metal-binding site 512566005836 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 512566005837 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 512566005838 putative catalytic cysteine [active] 512566005839 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 512566005840 putative active site [active] 512566005841 metal binding site [ion binding]; metal-binding site 512566005842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 512566005843 MORN repeat; Region: MORN; cl14787 512566005844 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 512566005845 Low molecular weight phosphatase family; Region: LMWPc; cd00115 512566005846 active site 512566005847 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 512566005848 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 512566005849 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 512566005850 TPP-binding site [chemical binding]; other site 512566005851 dimer interface [polypeptide binding]; other site 512566005852 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 512566005853 PYR/PP interface [polypeptide binding]; other site 512566005854 dimer interface [polypeptide binding]; other site 512566005855 TPP binding site [chemical binding]; other site 512566005856 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 512566005857 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 512566005858 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 512566005859 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 512566005860 PRD domain; Region: PRD; pfam00874 512566005861 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 512566005862 active site 512566005863 P-loop; other site 512566005864 phosphorylation site [posttranslational modification] 512566005865 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 512566005866 Zn2+ binding site [ion binding]; other site 512566005867 intersubunit interface [polypeptide binding]; other site 512566005868 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 512566005869 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 512566005870 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 512566005871 AP (apurinic/apyrimidinic) site pocket; other site 512566005872 DNA interaction; other site 512566005873 Metal-binding active site; metal-binding site 512566005874 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 512566005875 active site 512566005876 dimer interface [polypeptide binding]; other site 512566005877 magnesium binding site [ion binding]; other site 512566005878 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 512566005879 active site 512566005880 phosphorylation site [posttranslational modification] 512566005881 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 512566005882 active site 512566005883 P-loop; other site 512566005884 phosphorylation site [posttranslational modification] 512566005885 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 512566005886 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 512566005887 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 512566005888 G-X-X-G motif; other site 512566005889 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 512566005890 RxxxH motif; other site 512566005891 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 512566005892 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 512566005893 ribonuclease P; Reviewed; Region: rnpA; PRK00499 512566005894 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 512566005895 propionate/acetate kinase; Provisional; Region: PRK12379 512566005896 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 512566005897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566005898 S-adenosylmethionine binding site [chemical binding]; other site 512566005899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566005900 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 512566005901 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 512566005902 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 512566005903 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 512566005904 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 512566005905 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 512566005906 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 512566005907 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 512566005908 Walker A motif; other site 512566005909 ATP binding site [chemical binding]; other site 512566005910 Walker B motif; other site 512566005911 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 512566005912 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 512566005913 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 512566005914 catalytic Zn binding site [ion binding]; other site 512566005915 structural Zn binding site [ion binding]; other site 512566005916 NAD(P) binding site [chemical binding]; other site 512566005917 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 512566005918 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 512566005919 active site 512566005920 dimer interface [polypeptide binding]; other site 512566005921 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 512566005922 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 512566005923 catalytic triad [active] 512566005924 catalytic triad [active] 512566005925 oxyanion hole [active] 512566005926 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 512566005927 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 512566005928 Predicted integral membrane protein [Function unknown]; Region: COG5523 512566005929 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 512566005930 putative substrate binding pocket [chemical binding]; other site 512566005931 AC domain interface; other site 512566005932 catalytic triad [active] 512566005933 AB domain interface; other site 512566005934 interchain disulfide; other site 512566005935 Predicted membrane protein [Function unknown]; Region: COG3759 512566005936 MarR family; Region: MarR; pfam01047 512566005937 Transcriptional regulators [Transcription]; Region: MarR; COG1846 512566005938 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 512566005939 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 512566005940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566005941 motif II; other site 512566005942 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 512566005943 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 512566005944 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 512566005945 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 512566005946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512566005947 catalytic residue [active] 512566005948 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 512566005949 integrase; Provisional; Region: int; PHA02601 512566005950 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 512566005951 Int/Topo IB signature motif; other site 512566005952 HD domain; Region: HD_4; pfam13328 512566005953 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 512566005954 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 512566005955 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 512566005956 active site 512566005957 metal binding site [ion binding]; metal-binding site 512566005958 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 512566005959 active site 512566005960 catalytic motif [active] 512566005961 Zn binding site [ion binding]; other site 512566005962 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 512566005963 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 512566005964 active site 512566005965 HIGH motif; other site 512566005966 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 512566005967 active site 512566005968 KMSKS motif; other site 512566005969 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 512566005970 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 512566005971 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 512566005972 active site 512566005973 dimer interface [polypeptide binding]; other site 512566005974 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 512566005975 dimer interface [polypeptide binding]; other site 512566005976 active site 512566005977 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 512566005978 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 512566005979 catalytic triad [active] 512566005980 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512566005981 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512566005982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566005983 Walker A/P-loop; other site 512566005984 ATP binding site [chemical binding]; other site 512566005985 Q-loop/lid; other site 512566005986 ABC transporter signature motif; other site 512566005987 Walker B; other site 512566005988 D-loop; other site 512566005989 H-loop/switch region; other site 512566005990 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 512566005991 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512566005992 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512566005993 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566005994 Walker A/P-loop; other site 512566005995 ATP binding site [chemical binding]; other site 512566005996 Q-loop/lid; other site 512566005997 ABC transporter signature motif; other site 512566005998 Walker B; other site 512566005999 D-loop; other site 512566006000 H-loop/switch region; other site 512566006001 DNA mismatch repair protein MutS; Region: mutS1; TIGR01070 512566006002 MutS domain I; Region: MutS_I; pfam01624 512566006003 MutS domain II; Region: MutS_II; pfam05188 512566006004 MutS domain III; Region: MutS_III; pfam05192 512566006005 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 512566006006 Walker A/P-loop; other site 512566006007 ATP binding site [chemical binding]; other site 512566006008 Q-loop/lid; other site 512566006009 ABC transporter signature motif; other site 512566006010 Walker B; other site 512566006011 D-loop; other site 512566006012 H-loop/switch region; other site 512566006013 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 512566006014 arginine repressor; Region: argR_whole; TIGR01529 512566006015 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 512566006016 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 512566006017 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 512566006018 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 512566006019 active site 512566006020 HIGH motif; other site 512566006021 KMSK motif region; other site 512566006022 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 512566006023 tRNA binding surface [nucleotide binding]; other site 512566006024 anticodon binding site; other site 512566006025 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 512566006026 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 512566006027 Uncharacterized conserved protein [Function unknown]; Region: COG3542 512566006028 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512566006029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512566006030 active site 512566006031 phosphorylation site [posttranslational modification] 512566006032 intermolecular recognition site; other site 512566006033 dimerization interface [polypeptide binding]; other site 512566006034 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512566006035 DNA binding site [nucleotide binding] 512566006036 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 512566006037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512566006038 dimer interface [polypeptide binding]; other site 512566006039 phosphorylation site [posttranslational modification] 512566006040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566006041 ATP binding site [chemical binding]; other site 512566006042 G-X-G motif; other site 512566006043 PBP superfamily domain; Region: PBP_like_2; cl17296 512566006044 PBP superfamily domain; Region: PBP_like_2; cl17296 512566006045 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 512566006046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566006047 dimer interface [polypeptide binding]; other site 512566006048 conserved gate region; other site 512566006049 putative PBP binding loops; other site 512566006050 ABC-ATPase subunit interface; other site 512566006051 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 512566006052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566006053 dimer interface [polypeptide binding]; other site 512566006054 conserved gate region; other site 512566006055 putative PBP binding loops; other site 512566006056 ABC-ATPase subunit interface; other site 512566006057 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 512566006058 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 512566006059 Walker A/P-loop; other site 512566006060 ATP binding site [chemical binding]; other site 512566006061 Q-loop/lid; other site 512566006062 ABC transporter signature motif; other site 512566006063 Walker B; other site 512566006064 D-loop; other site 512566006065 H-loop/switch region; other site 512566006066 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 512566006067 PhoU domain; Region: PhoU; pfam01895 512566006068 PhoU domain; Region: PhoU; pfam01895 512566006069 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 512566006070 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 512566006071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566006072 non-specific DNA binding site [nucleotide binding]; other site 512566006073 salt bridge; other site 512566006074 sequence-specific DNA binding site [nucleotide binding]; other site 512566006075 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 512566006076 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 512566006077 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 512566006078 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 512566006079 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 512566006080 active site 512566006081 tetramer interface; other site 512566006082 Rhomboid family; Region: Rhomboid; pfam01694 512566006083 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 512566006084 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 512566006085 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 512566006086 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 512566006087 metal binding site [ion binding]; metal-binding site 512566006088 putative dimer interface [polypeptide binding]; other site 512566006089 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 512566006090 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 512566006091 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 512566006092 trimer interface [polypeptide binding]; other site 512566006093 active site 512566006094 substrate binding site [chemical binding]; other site 512566006095 CoA binding site [chemical binding]; other site 512566006096 EamA-like transporter family; Region: EamA; pfam00892 512566006097 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 512566006098 Transglycosylase; Region: Transgly; pfam00912 512566006099 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 512566006100 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 512566006101 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 512566006102 active site 512566006103 HIGH motif; other site 512566006104 dimer interface [polypeptide binding]; other site 512566006105 KMSKS motif; other site 512566006106 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512566006107 RNA binding surface [nucleotide binding]; other site 512566006108 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 512566006109 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 512566006110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512566006111 motif II; other site 512566006112 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 512566006113 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512566006114 S-adenosylmethionine binding site [chemical binding]; other site 512566006115 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 512566006116 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 512566006117 4-alpha-glucanotransferase; Provisional; Region: PRK14508 512566006118 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 512566006119 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512566006120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566006121 dimer interface [polypeptide binding]; other site 512566006122 conserved gate region; other site 512566006123 putative PBP binding loops; other site 512566006124 ABC-ATPase subunit interface; other site 512566006125 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512566006126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566006127 dimer interface [polypeptide binding]; other site 512566006128 conserved gate region; other site 512566006129 putative PBP binding loops; other site 512566006130 ABC-ATPase subunit interface; other site 512566006131 Predicted integral membrane protein [Function unknown]; Region: COG5521 512566006132 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512566006133 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512566006134 DNA binding site [nucleotide binding] 512566006135 domain linker motif; other site 512566006136 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 512566006137 putative dimerization interface [polypeptide binding]; other site 512566006138 putative ligand binding site [chemical binding]; other site 512566006139 Uncharacterized conserved protein [Function unknown]; Region: COG1284 512566006140 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 512566006141 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 512566006142 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 512566006143 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 512566006144 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 512566006145 dimer interface [polypeptide binding]; other site 512566006146 anticodon binding site; other site 512566006147 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 512566006148 homodimer interface [polypeptide binding]; other site 512566006149 motif 1; other site 512566006150 active site 512566006151 motif 2; other site 512566006152 GAD domain; Region: GAD; pfam02938 512566006153 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 512566006154 motif 3; other site 512566006155 CAAX protease self-immunity; Region: Abi; pfam02517 512566006156 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 512566006157 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566006158 non-specific DNA binding site [nucleotide binding]; other site 512566006159 salt bridge; other site 512566006160 sequence-specific DNA binding site [nucleotide binding]; other site 512566006161 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 512566006162 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 512566006163 dimer interface [polypeptide binding]; other site 512566006164 motif 1; other site 512566006165 active site 512566006166 motif 2; other site 512566006167 motif 3; other site 512566006168 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 512566006169 anticodon binding site; other site 512566006170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 512566006171 non-specific DNA binding site [nucleotide binding]; other site 512566006172 salt bridge; other site 512566006173 sequence-specific DNA binding site [nucleotide binding]; other site 512566006174 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 512566006175 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 512566006176 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 512566006177 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 512566006178 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 512566006179 PYR/PP interface [polypeptide binding]; other site 512566006180 dimer interface [polypeptide binding]; other site 512566006181 TPP binding site [chemical binding]; other site 512566006182 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 512566006183 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 512566006184 TPP-binding site [chemical binding]; other site 512566006185 dimer interface [polypeptide binding]; other site 512566006186 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 512566006187 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 512566006188 active site 512566006189 P-loop; other site 512566006190 phosphorylation site [posttranslational modification] 512566006191 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 512566006192 active site 512566006193 phosphorylation site [posttranslational modification] 512566006194 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 512566006195 PRD domain; Region: PRD; pfam00874 512566006196 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 512566006197 active site 512566006198 P-loop; other site 512566006199 phosphorylation site [posttranslational modification] 512566006200 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 512566006201 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 512566006202 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 512566006203 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 512566006204 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 512566006205 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 512566006206 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 512566006207 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 512566006208 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566006209 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566006210 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566006211 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566006212 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566006213 Divergent AAA domain; Region: AAA_4; pfam04326 512566006214 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 512566006215 DDE superfamily endonuclease; Region: DDE_4; cl17710 512566006216 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 512566006217 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 512566006218 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 512566006219 putative active site [active] 512566006220 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 512566006221 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512566006222 nucleotide binding site [chemical binding]; other site 512566006223 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 512566006224 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 512566006225 active site 512566006226 metal binding site [ion binding]; metal-binding site 512566006227 homodimer interface [polypeptide binding]; other site 512566006228 catalytic site [active] 512566006229 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 512566006230 Uncharacterized conserved protein [Function unknown]; Region: COG3538 512566006231 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 512566006232 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 512566006233 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 512566006234 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 512566006235 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 512566006236 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512566006237 arginine deiminase; Provisional; Region: PRK01388 512566006238 ornithine carbamoyltransferase; Validated; Region: PRK02102 512566006239 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 512566006240 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 512566006241 carbamate kinase; Reviewed; Region: PRK12686 512566006242 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 512566006243 putative substrate binding site [chemical binding]; other site 512566006244 nucleotide binding site [chemical binding]; other site 512566006245 nucleotide binding site [chemical binding]; other site 512566006246 homodimer interface [polypeptide binding]; other site 512566006247 Predicted membrane protein [Function unknown]; Region: COG1288 512566006248 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 512566006249 hypothetical protein; Provisional; Region: PRK07205 512566006250 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 512566006251 active site 512566006252 metal binding site [ion binding]; metal-binding site 512566006253 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 512566006254 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 512566006255 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 512566006256 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 512566006257 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 512566006258 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 512566006259 dimer interface [polypeptide binding]; other site 512566006260 active site 512566006261 metal binding site [ion binding]; metal-binding site 512566006262 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 512566006263 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 512566006264 hexamer (dimer of trimers) interface [polypeptide binding]; other site 512566006265 trimer interface [polypeptide binding]; other site 512566006266 substrate binding site [chemical binding]; other site 512566006267 Mn binding site [ion binding]; other site 512566006268 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 512566006269 intersubunit interface [polypeptide binding]; other site 512566006270 active site 512566006271 Zn2+ binding site [ion binding]; other site 512566006272 Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306 512566006273 Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307 512566006274 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 512566006275 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 512566006276 Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306 512566006277 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 512566006278 Melibiase; Region: Melibiase; pfam02065 512566006279 Melibiase; Region: Melibiase; pfam02065 512566006280 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 512566006281 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 512566006282 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512566006283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566006284 dimer interface [polypeptide binding]; other site 512566006285 conserved gate region; other site 512566006286 putative PBP binding loops; other site 512566006287 ABC-ATPase subunit interface; other site 512566006288 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512566006289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512566006290 dimer interface [polypeptide binding]; other site 512566006291 conserved gate region; other site 512566006292 putative PBP binding loops; other site 512566006293 ABC-ATPase subunit interface; other site 512566006294 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 512566006295 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 512566006296 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 512566006297 N- and C-terminal domain interface [polypeptide binding]; other site 512566006298 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 512566006299 active site 512566006300 putative catalytic site [active] 512566006301 metal binding site [ion binding]; metal-binding site 512566006302 ATP binding site [chemical binding]; other site 512566006303 carbohydrate binding site [chemical binding]; other site 512566006304 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 512566006305 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 512566006306 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 512566006307 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 512566006308 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 512566006309 metal binding site [ion binding]; metal-binding site 512566006310 YodA lipocalin-like domain; Region: YodA; pfam09223 512566006311 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 512566006312 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 512566006313 ABC-ATPase subunit interface; other site 512566006314 dimer interface [polypeptide binding]; other site 512566006315 putative PBP binding regions; other site 512566006316 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512566006317 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 512566006318 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512566006319 putative DNA binding site [nucleotide binding]; other site 512566006320 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 512566006321 DltD N-terminal region; Region: DltD_N; pfam04915 512566006322 DltD central region; Region: DltD_M; pfam04918 512566006323 DltD C-terminal region; Region: DltD_C; pfam04914 512566006324 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 512566006325 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 512566006326 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 512566006327 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 512566006328 acyl-activating enzyme (AAE) consensus motif; other site 512566006329 AMP binding site [chemical binding]; other site 512566006330 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 512566006331 H+ Antiporter protein; Region: 2A0121; TIGR00900 512566006332 putative substrate translocation pore; other site 512566006333 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 512566006334 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 512566006335 putative active site [active] 512566006336 putative NTP binding site [chemical binding]; other site 512566006337 putative nucleic acid binding site [nucleotide binding]; other site 512566006338 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 512566006339 proline/glycine betaine transporter; Provisional; Region: PRK10642 512566006340 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 512566006341 amphipathic channel; other site 512566006342 Asn-Pro-Ala signature motifs; other site 512566006343 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 512566006344 glycerol kinase; Provisional; Region: glpK; PRK00047 512566006345 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 512566006346 N- and C-terminal domain interface [polypeptide binding]; other site 512566006347 active site 512566006348 MgATP binding site [chemical binding]; other site 512566006349 catalytic site [active] 512566006350 metal binding site [ion binding]; metal-binding site 512566006351 glycerol binding site [chemical binding]; other site 512566006352 homotetramer interface [polypeptide binding]; other site 512566006353 homodimer interface [polypeptide binding]; other site 512566006354 FBP binding site [chemical binding]; other site 512566006355 protein IIAGlc interface [polypeptide binding]; other site 512566006356 Mga helix-turn-helix domain; Region: Mga; pfam05043 512566006357 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 512566006358 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 512566006359 dimerization interface [polypeptide binding]; other site 512566006360 domain crossover interface; other site 512566006361 redox-dependent activation switch; other site 512566006362 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 512566006363 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 512566006364 FMN binding site [chemical binding]; other site 512566006365 active site 512566006366 catalytic residues [active] 512566006367 substrate binding site [chemical binding]; other site 512566006368 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 512566006369 Homeodomain-like domain; Region: HTH_23; cl17451 512566006370 Transposase; Region: HTH_Tnp_1; cl17663 512566006371 putative transposase OrfB; Reviewed; Region: PHA02517 512566006372 HTH-like domain; Region: HTH_21; pfam13276 512566006373 Integrase core domain; Region: rve; pfam00665 512566006374 Integrase core domain; Region: rve_2; pfam13333 512566006375 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 512566006376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 512566006377 Transposase; Region: DDE_Tnp_ISL3; pfam01610 512566006378 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 512566006379 RICH domain; Region: RICH; pfam05062 512566006380 RICH domain; Region: RICH; pfam05062 512566006381 AF-4 proto-oncoprotein; Region: AF-4; pfam05110 512566006382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 512566006383 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 512566006384 HAMP domain; Region: HAMP; pfam00672 512566006385 dimerization interface [polypeptide binding]; other site 512566006386 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 512566006387 dimer interface [polypeptide binding]; other site 512566006388 phosphorylation site [posttranslational modification] 512566006389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512566006390 ATP binding site [chemical binding]; other site 512566006391 Mg2+ binding site [ion binding]; other site 512566006392 G-X-G motif; other site 512566006393 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 512566006394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512566006395 active site 512566006396 phosphorylation site [posttranslational modification] 512566006397 intermolecular recognition site; other site 512566006398 dimerization interface [polypeptide binding]; other site 512566006399 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 512566006400 DNA binding site [nucleotide binding] 512566006401 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 512566006402 Clp amino terminal domain; Region: Clp_N; pfam02861 512566006403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512566006404 Walker A motif; other site 512566006405 ATP binding site [chemical binding]; other site 512566006406 Walker B motif; other site 512566006407 arginine finger; other site 512566006408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512566006409 Walker A motif; other site 512566006410 ATP binding site [chemical binding]; other site 512566006411 Walker B motif; other site 512566006412 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 512566006413 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 512566006414 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 512566006415 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 512566006416 Walker A/P-loop; other site 512566006417 ATP binding site [chemical binding]; other site 512566006418 Q-loop/lid; other site 512566006419 ABC transporter signature motif; other site 512566006420 Walker B; other site 512566006421 D-loop; other site 512566006422 H-loop/switch region; other site 512566006423 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 512566006424 NMT1/THI5 like; Region: NMT1; pfam09084 512566006425 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 512566006426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 512566006427 putative PBP binding loops; other site 512566006428 ABC-ATPase subunit interface; other site 512566006429 Uncharacterized conserved protein [Function unknown]; Region: COG0011 512566006430 Surface antigen [General function prediction only]; Region: COG3942 512566006431 CHAP domain; Region: CHAP; pfam05257 512566006432 Bacterial SH3 domain; Region: SH3_5; pfam08460 512566006433 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 512566006434 Bacterial SH3 domain; Region: SH3_5; pfam08460 512566006435 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 512566006436 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 512566006437 replicative DNA helicase; Provisional; Region: PRK05748 512566006438 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 512566006439 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 512566006440 Walker A motif; other site 512566006441 ATP binding site [chemical binding]; other site 512566006442 Walker B motif; other site 512566006443 DNA binding loops [nucleotide binding] 512566006444 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 512566006445 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 512566006446 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 512566006447 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 512566006448 DHH family; Region: DHH; pfam01368 512566006449 DHHA1 domain; Region: DHHA1; pfam02272 512566006450 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 512566006451 30S subunit binding site; other site 512566006452 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 512566006453 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512566006454 active site 512566006455 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 512566006456 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512566006457 ATP binding site [chemical binding]; other site 512566006458 putative Mg++ binding site [ion binding]; other site 512566006459 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512566006460 nucleotide binding region [chemical binding]; other site 512566006461 ATP-binding site [chemical binding]; other site 512566006462 Uncharacterized conserved protein [Function unknown]; Region: COG1739 512566006463 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 512566006464 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 512566006465 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 512566006466 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 512566006467 dimer interface [polypeptide binding]; other site 512566006468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 512566006469 catalytic residue [active] 512566006470 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 512566006471 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 512566006472 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 512566006473 DDE superfamily endonuclease; Region: DDE_3; pfam13358 512566006474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 512566006475 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 512566006476 elongation factor Ts; Provisional; Region: tsf; PRK09377 512566006477 UBA/TS-N domain; Region: UBA; pfam00627 512566006478 Elongation factor TS; Region: EF_TS; pfam00889 512566006479 Elongation factor TS; Region: EF_TS; pfam00889 512566006480 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 512566006481 rRNA interaction site [nucleotide binding]; other site 512566006482 S8 interaction site; other site 512566006483 putative laminin-1 binding site; other site 512566006484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 512566006485 Septum formation initiator; Region: DivIC; cl17659 512566006486 Surface antigen [General function prediction only]; Region: COG3942 512566006487 CHAP domain; Region: CHAP; pfam05257 512566006488 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 512566006489 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 512566006490 rod shape-determining protein MreC; Region: MreC; pfam04085 512566006491 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 512566006492 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 512566006493 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 512566006494 Walker A/P-loop; other site 512566006495 ATP binding site [chemical binding]; other site 512566006496 Q-loop/lid; other site 512566006497 ABC transporter signature motif; other site 512566006498 Walker B; other site 512566006499 D-loop; other site 512566006500 H-loop/switch region; other site 512566006501 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 512566006502 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 512566006503 Walker A/P-loop; other site 512566006504 ATP binding site [chemical binding]; other site 512566006505 Q-loop/lid; other site 512566006506 ABC transporter signature motif; other site 512566006507 Walker B; other site 512566006508 D-loop; other site 512566006509 H-loop/switch region; other site 512566006510 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 512566006511 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 512566006512 Helix-turn-helix domain; Region: HTH_25; pfam13413 512566006513 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 512566006514 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 512566006515 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 512566006516 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 512566006517 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 512566006518 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 512566006519 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 512566006520 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 512566006521 Walker A/P-loop; other site 512566006522 ATP binding site [chemical binding]; other site 512566006523 Q-loop/lid; other site 512566006524 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512566006525 ABC transporter signature motif; other site 512566006526 Walker B; other site 512566006527 D-loop; other site 512566006528 H-loop/switch region; other site 512566006529 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 512566006530 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 512566006531 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 512566006532 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 512566006533 active site 512566006534 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 512566006535 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 512566006536 active site 512566006537 HIGH motif; other site 512566006538 dimer interface [polypeptide binding]; other site 512566006539 KMSKS motif; other site 512566006540 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 512566006541 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512566006542 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512566006543 ABC transporter; Region: ABC_tran_2; pfam12848 512566006544 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512566006545 Predicted membrane protein [Function unknown]; Region: COG4485 512566006546 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 512566006547 Predicted membrane protein [Function unknown]; Region: COG1511 512566006548 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 512566006549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 512566006550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 512566006551 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 512566006552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 512566006553 active site 512566006554 phosphorylation site [posttranslational modification] 512566006555 intermolecular recognition site; other site 512566006556 dimerization interface [polypeptide binding]; other site 512566006557 LytTr DNA-binding domain; Region: LytTR; pfam04397 512566006558 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 512566006559 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 512566006560 COMC family; Region: ComC; pfam03047 512566006561 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 512566006562 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 512566006563 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 512566006564 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 512566006565 protein binding site [polypeptide binding]; other site 512566006566 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 512566006567 ParB-like nuclease domain; Region: ParBc; pfam02195 512566006568 KorB domain; Region: KorB; pfam08535