-- dump date 20140620_084636 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 487214000001 SEQ_END SEQ_END NC_010380.1 2245615 2245615 DR NC_010380.1; contig end 2245615..2245615 Streptococcus pneumoniae Hungary19A-6 YP_001693435.1 CDS dnaA NC_010380.1 197 1558 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 197..1558 Streptococcus pneumoniae Hungary19A-6 6028253 YP_001693436.1 CDS dnaN NC_010380.1 1717 2853 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1717..2853 Streptococcus pneumoniae Hungary19A-6 6029212 YP_001693437.1 CDS SPH_0003 NC_010380.1 2918 3112 D identified by match to protein family HMM PF06107; hypothetical protein 2918..3112 Streptococcus pneumoniae Hungary19A-6 6029508 YP_001693438.1 CDS ychF NC_010380.1 3196 4311 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 3196..4311 Streptococcus pneumoniae Hungary19A-6 6028195 YP_001693439.1 CDS pth NC_010380.1 4382 4951 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4382..4951 Streptococcus pneumoniae Hungary19A-6 6029225 YP_001693440.1 CDS mfd NC_010380.1 4952 8461 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580; transcription-repair coupling factor 4952..8461 Streptococcus pneumoniae Hungary19A-6 6029436 YP_001693441.1 CDS SPH_0007 NC_010380.1 8519 8785 D identified by match to protein family HMM PF01479; ribosome-associated heat shock protein implicated in the recycling of the 50S subunit 8519..8785 Streptococcus pneumoniae Hungary19A-6 6028089 YP_001693442.1 CDS SPH_0008 NC_010380.1 8778 9146 D identified by match to protein family HMM PF04977; septum formation initiator 8778..9146 Streptococcus pneumoniae Hungary19A-6 6028571 YP_001693443.1 CDS SPH_0009 NC_010380.1 9151 9273 D hypothetical protein 9151..9273 Streptococcus pneumoniae Hungary19A-6 6028866 YP_001693444.1 CDS SPH_0010 NC_010380.1 9266 10534 D beta-lactamase class A 9266..10534 Streptococcus pneumoniae Hungary19A-6 6027765 YP_001693445.1 CDS SPH_0011 NC_010380.1 10531 11808 D identified by match to protein family HMM PF01171; match to protein family HMM TIGR02432; match to protein family HMM TIGR02433; tRNA(Ile)-lysidine synthase (tRNA(Ile)-lysidinesynthetase) (tRNA(Ile)-2-lysyl-cytidine synthase) 10531..11808 Streptococcus pneumoniae Hungary19A-6 6028196 YP_001693446.1 CDS hpt NC_010380.1 11812 12354 D identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; hypoxanthine phosphoribosyltransferase 11812..12354 Streptococcus pneumoniae Hungary19A-6 6030015 YP_001693447.1 CDS hflB NC_010380.1 12370 14328 D identified by match to protein family HMM PF00004; match to protein family HMM PF01434; match to protein family HMM PF06480; match to protein family HMM TIGR01241; ATP-dependent metallopeptidase HflB 12370..14328 Streptococcus pneumoniae Hungary19A-6 6029031 YP_001693448.1 CDS SPH_0014 NC_010380.1 14450 14929 D competence-specific global transcription modulator 14450..14929 Streptococcus pneumoniae Hungary19A-6 6028713 YP_001693449.1 CDS SPH_0024 NC_010380.1 21502 21738 D hypothetical protein 21502..21738 Streptococcus pneumoniae Hungary19A-6 6027718 YP_001693450.1 CDS purA NC_010380.1 21927 23255 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 21927..23255 Streptococcus pneumoniae Hungary19A-6 6028241 YP_001693451.1 CDS SPH_0026 NC_010380.1 23497 24645 R identified by match to protein family HMM PF00589; integrase complement(23497..24645) Streptococcus pneumoniae Hungary19A-6 6029955 YP_001693452.1 CDS SPH_0028 NC_010380.1 24816 25616 R identified by glimmer; hypothetical protein complement(24816..25616) Streptococcus pneumoniae Hungary19A-6 6029660 YP_001693453.1 CDS SPH_0029 NC_010380.1 25743 26498 R identified by match to protein family HMM PF00717; match to protein family HMM PF01381; phage transcriptional repressor complement(25743..26498) Streptococcus pneumoniae Hungary19A-6 6029444 YP_001693454.1 CDS SPH_0030 NC_010380.1 26672 26878 D identified by match to protein family HMM PF01381; hypothetical protein 26672..26878 Streptococcus pneumoniae Hungary19A-6 6027736 YP_001693455.1 CDS SPH_0031 NC_010380.1 26949 27083 D identified by glimmer; hypothetical protein 26949..27083 Streptococcus pneumoniae Hungary19A-6 6029562 YP_001693456.1 CDS SPH_0033 NC_010380.1 27095 27223 D hypothetical protein 27095..27223 Streptococcus pneumoniae Hungary19A-6 6029427 YP_001693457.1 CDS SPH_0032 NC_010380.1 27186 27863 R hypothetical protein complement(27186..27863) Streptococcus pneumoniae Hungary19A-6 6028428 YP_001693458.1 CDS SPH_0034 NC_010380.1 27918 28631 D identified by match to protein family HMM PF02498; hypothetical protein 27918..28631 Streptococcus pneumoniae Hungary19A-6 6027986 YP_001693459.1 CDS SPH_0035 NC_010380.1 28644 28901 D phage protein 28644..28901 Streptococcus pneumoniae Hungary19A-6 6029075 YP_001693460.1 CDS SPH_0036 NC_010380.1 28987 29307 D hypothetical protein 28987..29307 Streptococcus pneumoniae Hungary19A-6 6029626 YP_001693461.1 CDS SPH_0037 NC_010380.1 29323 29616 D hypothetical protein 29323..29616 Streptococcus pneumoniae Hungary19A-6 6027722 YP_001693462.1 CDS SPH_0038 NC_010380.1 29600 30448 D identified by match to protein family HMM PF04271; match to protein family HMM TIGR01446; match to protein family HMM TIGR01714; hypothetical protein 29600..30448 Streptococcus pneumoniae Hungary19A-6 6028083 YP_001693463.1 CDS SPH_0039 NC_010380.1 30436 30594 D hypothetical protein 30436..30594 Streptococcus pneumoniae Hungary19A-6 6029309 YP_001693464.1 CDS SPH_0040 NC_010380.1 30588 31358 D hypothetical protein 30588..31358 Streptococcus pneumoniae Hungary19A-6 6028332 YP_001693465.1 CDS SPH_0041 NC_010380.1 31373 31567 D identified by glimmer; hypothetical protein 31373..31567 Streptococcus pneumoniae Hungary19A-6 6027914 YP_001693466.1 CDS SPH_0042 NC_010380.1 31567 31794 D hypothetical protein 31567..31794 Streptococcus pneumoniae Hungary19A-6 6028461 YP_001693467.1 CDS SPH_0043 NC_010380.1 31979 32170 D identified by glimmer; hypothetical protein 31979..32170 Streptococcus pneumoniae Hungary19A-6 6027715 YP_001693468.1 CDS SPH_0044 NC_010380.1 32160 32492 D hypothetical protein 32160..32492 Streptococcus pneumoniae Hungary19A-6 6028287 YP_001693469.1 CDS SPH_0045 NC_010380.1 32532 32996 D hypothetical protein 32532..32996 Streptococcus pneumoniae Hungary19A-6 6028930 YP_001693470.1 CDS SPH_0046 NC_010380.1 33105 33647 D identified by match to protein family HMM PF00589; prophage LambdaSa2, site-specific recombinase phage integrase 33105..33647 Streptococcus pneumoniae Hungary19A-6 6029137 YP_001693471.1 CDS SPH_0047 NC_010380.1 34077 34394 D identified by match to protein family HMM PF01844; HNH endonuclease domain-containing protein 34077..34394 Streptococcus pneumoniae Hungary19A-6 6029195 YP_001693472.1 CDS SPH_0048 NC_010380.1 34537 35016 D hypothetical protein 34537..35016 Streptococcus pneumoniae Hungary19A-6 6028108 YP_001693473.1 CDS SPH_0049 NC_010380.1 35009 36721 D identified by match to protein family HMM PF03354; phage terminase, large subunit 35009..36721 Streptococcus pneumoniae Hungary19A-6 6029004 YP_001693474.1 CDS SPH_0050 NC_010380.1 36946 37872 D hypothetical protein 36946..37872 Streptococcus pneumoniae Hungary19A-6 6028205 YP_001693475.1 CDS SPH_0051 NC_010380.1 37919 38461 D identified by match to protein family HMM PF04586; match to protein family HMM TIGR01543; HK97 family phage prohead protease 37919..38461 Streptococcus pneumoniae Hungary19A-6 6029522 YP_001693476.1 CDS SPH_0052 NC_010380.1 38476 39729 D hypothetical protein 38476..39729 Streptococcus pneumoniae Hungary19A-6 6029524 YP_001693477.1 CDS SPH_0053 NC_010380.1 39755 40090 D hypothetical protein 39755..40090 Streptococcus pneumoniae Hungary19A-6 6028395 YP_001693478.1 CDS SPH_0054 NC_010380.1 40087 40392 D identified by match to protein family HMM TIGR01563; phage head-tail adaptor 40087..40392 Streptococcus pneumoniae Hungary19A-6 6030046 YP_001693479.1 CDS SPH_0055 NC_010380.1 40392 40739 D hypothetical protein 40392..40739 Streptococcus pneumoniae Hungary19A-6 6028697 YP_001693480.1 CDS SPH_0056 NC_010380.1 40726 41070 D hypothetical protein 40726..41070 Streptococcus pneumoniae Hungary19A-6 6028447 YP_001693481.1 CDS SPH_0057 NC_010380.1 41084 41752 D identified by match to protein family HMM TIGR01603; phi13 family phage major tail protein 41084..41752 Streptococcus pneumoniae Hungary19A-6 6028385 YP_001693482.1 CDS SPH_0058 NC_010380.1 41754 42230 D hypothetical protein 41754..42230 Streptococcus pneumoniae Hungary19A-6 6028753 YP_001693483.1 CDS SPH_0059 NC_010380.1 42269 42397 D hypothetical protein 42269..42397 Streptococcus pneumoniae Hungary19A-6 6029263 YP_001693484.1 CDS SPH_0060 NC_010380.1 42417 45155 D identified by match to protein family HMM TIGR01760; prophage LambdaSa04, tail tape measure family protein 42417..45155 Streptococcus pneumoniae Hungary19A-6 6029658 YP_001693485.1 CDS SPH_0061 NC_010380.1 45152 45874 D hypothetical protein 45152..45874 Streptococcus pneumoniae Hungary19A-6 6029981 YP_001693486.1 CDS SPH_0062 NC_010380.1 45875 54991 D identified by match to protein family HMM TIGR01665; hypothetical protein 45875..54991 Streptococcus pneumoniae Hungary19A-6 6027755 YP_001693487.1 CDS SPH_0063 NC_010380.1 55085 55288 D hypothetical protein 55085..55288 Streptococcus pneumoniae Hungary19A-6 6028864 YP_001693488.1 CDS SPH_0064 NC_010380.1 55291 55641 D hypothetical protein 55291..55641 Streptococcus pneumoniae Hungary19A-6 6030073 YP_001693489.1 CDS SPH_0065 NC_010380.1 55651 56067 D identified by match to protein family HMM PF05105; match to protein family HMM TIGR01593; holin 1 55651..56067 Streptococcus pneumoniae Hungary19A-6 6029924 YP_001693490.1 CDS SPH_0066 NC_010380.1 56071 56403 D identified by match to protein family HMM TIGR01673; phage holin 56071..56403 Streptococcus pneumoniae Hungary19A-6 6028999 YP_001693491.1 CDS SPH_0067 NC_010380.1 56407 57363 D identified by match to protein family HMM PF01473; match to protein family HMM PF01510; lytic amidase (N-acetylmuramoyl-L-alanine amidase) 56407..57363 Streptococcus pneumoniae Hungary19A-6 6029287 YP_001693492.1 CDS SPH_0068 NC_010380.1 57526 57681 R identified by glimmer; hypothetical protein complement(57526..57681) Streptococcus pneumoniae Hungary19A-6 6029785 YP_001693493.1 CDS SPH_0069 NC_010380.1 58253 58720 D identified by match to protein family HMM PF00383; tRNA-specific adenosine deaminase 58253..58720 Streptococcus pneumoniae Hungary19A-6 6028677 YP_001693494.1 CDS SPH_0070 NC_010380.1 58929 60071 R identified by match to protein family HMM PF00589; integrase complement(58929..60071) Streptococcus pneumoniae Hungary19A-6 6028844 YP_001693495.1 CDS SPH_0071 NC_010380.1 60190 60540 R hypothetical protein complement(60190..60540) Streptococcus pneumoniae Hungary19A-6 6029080 YP_001693496.1 CDS SPH_0072 NC_010380.1 60554 60934 R identified by match to protein family HMM PF06114; hypothetical protein complement(60554..60934) Streptococcus pneumoniae Hungary19A-6 6030076 YP_001693497.1 CDS SPH_0073 NC_010380.1 60956 61312 R identified by match to protein family HMM PF01381; repressor protein complement(60956..61312) Streptococcus pneumoniae Hungary19A-6 6029692 YP_001693498.1 CDS SPH_0074 NC_010380.1 61588 61773 D repressor 61588..61773 Streptococcus pneumoniae Hungary19A-6 6029285 YP_001693499.1 CDS SPH_0075 NC_010380.1 61775 62473 D identified by match to protein family HMM PF03374; match to protein family HMM PF08346; phage antirepressor protein 61775..62473 Streptococcus pneumoniae Hungary19A-6 6028673 YP_001693500.1 CDS SPH_0076 NC_010380.1 62659 63000 D phage replication protein 62659..63000 Streptococcus pneumoniae Hungary19A-6 6029375 YP_001693501.1 CDS SPH_0077 NC_010380.1 63157 63423 D hypothetical protein 63157..63423 Streptococcus pneumoniae Hungary19A-6 6029190 YP_001693502.1 CDS SPH_0078 NC_010380.1 63507 63959 D hypothetical protein 63507..63959 Streptococcus pneumoniae Hungary19A-6 6027946 YP_001693503.1 CDS SPH_0079 NC_010380.1 63965 64666 D identified by match to protein family HMM PF04404; Erf protein 63965..64666 Streptococcus pneumoniae Hungary19A-6 6028610 YP_001693504.1 CDS SPH_0080 NC_010380.1 64669 65661 D identified by match to protein family HMM PF07083; hypothetical protein 64669..65661 Streptococcus pneumoniae Hungary19A-6 6028568 YP_001693505.1 CDS SPH_0081 NC_010380.1 65683 65859 D hypothetical protein 65683..65859 Streptococcus pneumoniae Hungary19A-6 6029109 YP_001693506.1 CDS SPH_0082 NC_010380.1 65849 66394 D identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621; single-stranded DNA-binding protein (SSB) (helix-destabilizingprotein) 65849..66394 Streptococcus pneumoniae Hungary19A-6 6029115 YP_001693507.1 CDS SPH_0083 NC_010380.1 66420 67187 D identified by glimmer; hypothetical protein 66420..67187 Streptococcus pneumoniae Hungary19A-6 6029209 YP_001693508.1 CDS SPH_0084 NC_010380.1 67192 67560 D identified by glimmer; hypothetical protein 67192..67560 Streptococcus pneumoniae Hungary19A-6 6028181 YP_001693509.1 CDS SPH_0085 NC_010380.1 67595 67798 D hypothetical protein 67595..67798 Streptococcus pneumoniae Hungary19A-6 6029512 YP_001693510.1 CDS SPH_0086 NC_010380.1 67852 68286 D hypothetical protein 67852..68286 Streptococcus pneumoniae Hungary19A-6 6029849 YP_001693511.1 CDS SPH_0087 NC_010380.1 68288 69025 D hypothetical protein 68288..69025 Streptococcus pneumoniae Hungary19A-6 6028591 YP_001693512.1 CDS SPH_0088 NC_010380.1 69042 69254 D hypothetical protein 69042..69254 Streptococcus pneumoniae Hungary19A-6 6028938 YP_001693513.1 CDS SPH_0089 NC_010380.1 69508 69666 D RUS 69508..69666 Streptococcus pneumoniae Hungary19A-6 6027760 YP_001693514.1 CDS SPH_0090 NC_010380.1 69668 69874 D hypothetical protein 69668..69874 Streptococcus pneumoniae Hungary19A-6 6028496 YP_001693515.1 CDS SPH_0091 NC_010380.1 69924 70238 D hypothetical protein 69924..70238 Streptococcus pneumoniae Hungary19A-6 6030025 YP_001693516.1 CDS SPH_0092 NC_010380.1 70240 70740 D identified by match to protein family HMM PF07852; hypothetical protein 70240..70740 Streptococcus pneumoniae Hungary19A-6 6027932 YP_001693517.1 CDS SPH_0093 NC_010380.1 70740 71033 D hypothetical protein 70740..71033 Streptococcus pneumoniae Hungary19A-6 6027771 YP_001693518.1 CDS SPH_0094 NC_010380.1 71033 71425 D hypothetical protein 71033..71425 Streptococcus pneumoniae Hungary19A-6 6028750 YP_001693519.1 CDS SPH_0095 NC_010380.1 71497 72585 D identified by match to protein family HMM PF02195; hypothetical protein 71497..72585 Streptococcus pneumoniae Hungary19A-6 6027837 YP_001693520.1 CDS SPH_0097 NC_010380.1 72566 73312 D hypothetical protein 72566..73312 Streptococcus pneumoniae Hungary19A-6 6027798 YP_001693521.1 CDS SPH_0096 NC_010380.1 73278 73454 R identified by glimmer; hypothetical protein complement(73278..73454) Streptococcus pneumoniae Hungary19A-6 6028541 YP_001693522.1 CDS SPH_0098 NC_010380.1 73516 73974 D hypothetical protein 73516..73974 Streptococcus pneumoniae Hungary19A-6 6029245 YP_001693523.1 CDS SPH_0099 NC_010380.1 73964 75274 D identified by match to protein family HMM PF04466; match to protein family HMM PF07570; match to protein family HMM TIGR01547; PBSX family phage terminase large subunit 73964..75274 Streptococcus pneumoniae Hungary19A-6 6029566 YP_001693524.1 CDS SPH_0100 NC_010380.1 75287 76855 D identified by match to protein family HMM PF05126; match to protein family HMM TIGR01542; phage minor capsid protein 75287..76855 Streptococcus pneumoniae Hungary19A-6 6028801 YP_001693525.1 CDS SPH_0101 NC_010380.1 76842 77015 D hypothetical protein 76842..77015 Streptococcus pneumoniae Hungary19A-6 6028145 YP_001693526.1 CDS SPH_0102 NC_010380.1 77058 78209 D identified by match to protein family HMM PF06152; phage minor capsid protein 2 77058..78209 Streptococcus pneumoniae Hungary19A-6 6029747 YP_001693527.1 CDS SPH_0103 NC_010380.1 78348 78911 D identified by match to protein family HMM PF06810; phage minor structural protein GP20 78348..78911 Streptococcus pneumoniae Hungary19A-6 6028329 YP_001693528.1 CDS SPH_0104 NC_010380.1 78929 79810 D major capsid protein 78929..79810 Streptococcus pneumoniae Hungary19A-6 6029229 YP_001693529.1 CDS SPH_0105 NC_010380.1 79821 80054 D hypothetical protein 79821..80054 Streptococcus pneumoniae Hungary19A-6 6029003 YP_001693530.1 CDS SPH_0106 NC_010380.1 80097 80489 D hypothetical protein 80097..80489 Streptococcus pneumoniae Hungary19A-6 6029332 YP_001693531.1 CDS SPH_0107 NC_010380.1 80479 80850 D minor capsid protein 2 80479..80850 Streptococcus pneumoniae Hungary19A-6 6030084 YP_001693532.1 CDS SPH_0108 NC_010380.1 80850 81194 D minor capsid protein 80850..81194 Streptococcus pneumoniae Hungary19A-6 6029962 YP_001693533.1 CDS SPH_0109 NC_010380.1 81194 81601 D minor capsid protein 81194..81601 Streptococcus pneumoniae Hungary19A-6 6029917 YP_001693534.1 CDS SPH_0110 NC_010380.1 81598 82047 D major tail shaft protein 81598..82047 Streptococcus pneumoniae Hungary19A-6 6029769 YP_001693535.1 CDS SPH_0111 NC_010380.1 82112 82600 D hypothetical protein 82112..82600 Streptococcus pneumoniae Hungary19A-6 6028808 YP_001693536.1 CDS SPH_0112 NC_010380.1 82613 83182 D identified by match to protein family HMM PF06854; phage protein 82613..83182 Streptococcus pneumoniae Hungary19A-6 6029873 YP_001693537.1 CDS SPH_0113 NC_010380.1 83175 86456 D identified by match to protein family HMM TIGR02675; phage protein 83175..86456 Streptococcus pneumoniae Hungary19A-6 6028123 YP_001693538.1 CDS SPH_0114 NC_010380.1 86486 87967 D identified by match to protein family HMM PF05709; match to protein family HMM TIGR01633; tail protein 86486..87967 Streptococcus pneumoniae Hungary19A-6 6027704 YP_001693539.1 CDS SPH_0115 NC_010380.1 87969 94910 D identified by match to protein family HMM TIGR01665; phage minor structural protein 87969..94910 Streptococcus pneumoniae Hungary19A-6 6029819 YP_001693540.1 CDS SPH_0116 NC_010380.1 94921 96969 D identified by match to protein family HMM PF05895; structural protein 94921..96969 Streptococcus pneumoniae Hungary19A-6 6028653 YP_001693541.1 CDS SPH_0117 NC_010380.1 97029 97292 D hypothetical protein 97029..97292 Streptococcus pneumoniae Hungary19A-6 6029763 YP_001693542.1 CDS SPH_0118 NC_010380.1 97302 97718 D identified by match to protein family HMM PF05105; match to protein family HMM TIGR01593; holin 1 97302..97718 Streptococcus pneumoniae Hungary19A-6 6028511 YP_001693543.1 CDS SPH_0119 NC_010380.1 97722 98054 D identified by match to protein family HMM TIGR01673; phage holin 97722..98054 Streptococcus pneumoniae Hungary19A-6 6029454 YP_001693544.1 CDS dut NC_010380.1 99296 99739 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 99296..99739 Streptococcus pneumoniae Hungary19A-6 6028336 YP_001693545.1 CDS SPH_0123 NC_010380.1 99699 100256 D identified by match to protein family HMM PF00300; phosphoglycerate mutase 99699..100256 Streptococcus pneumoniae Hungary19A-6 6029442 YP_001693546.1 CDS radA NC_010380.1 100369 101631 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 100369..101631 Streptococcus pneumoniae Hungary19A-6 6028526 YP_001693547.1 CDS SPH_0125 NC_010380.1 101704 102201 D identified by match to protein family HMM PF00484; carbonate dehydratase 101704..102201 Streptococcus pneumoniae Hungary19A-6 6029648 YP_001693548.1 CDS SPH_0126 NC_010380.1 102222 103037 D hypothetical protein 102222..103037 Streptococcus pneumoniae Hungary19A-6 6029426 YP_001693549.1 CDS SPH_0127 NC_010380.1 103182 104150 D rppk; phosphoribosylpyrophosphate synthetase; p-rib-pp synthetase; prpp synthetase; catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 103182..104150 Streptococcus pneumoniae Hungary19A-6 6028326 YP_001693550.1 CDS SPH_0128 NC_010380.1 104692 104925 R hypothetical protein complement(104692..104925) Streptococcus pneumoniae Hungary19A-6 6028487 YP_001693551.1 CDS SPH_0129 NC_010380.1 104918 105034 R hypothetical protein complement(104918..105034) Streptococcus pneumoniae Hungary19A-6 6028373 YP_001693552.1 CDS SPH_0130 NC_010380.1 105249 105506 R hypothetical protein complement(105249..105506) Streptococcus pneumoniae Hungary19A-6 6027691 YP_001693553.1 CDS SPH_0131 NC_010380.1 105855 108488 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 105855..108488 Streptococcus pneumoniae Hungary19A-6 6028714 YP_001693554.1 CDS SPH_0132 NC_010380.1 108573 109010 D identified by match to protein family HMM PF02629; CoA binding protein 108573..109010 Streptococcus pneumoniae Hungary19A-6 6028933 YP_001693555.1 CDS SPH_0133 NC_010380.1 109051 109401 D identified by glimmer; hypothetical protein 109051..109401 Streptococcus pneumoniae Hungary19A-6 6027754 YP_001693556.1 CDS SPH_0134 NC_010380.1 109420 110430 R identified by match to protein family HMM PF03601; membrane protein Spr0034 complement(109420..110430) Streptococcus pneumoniae Hungary19A-6 6029230 YP_001693557.1 CDS SPH_0135 NC_010380.1 110579 111748 D catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 110579..111748 Streptococcus pneumoniae Hungary19A-6 6028246 YP_001693558.1 CDS recO NC_010380.1 111745 112515 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 111745..112515 Streptococcus pneumoniae Hungary19A-6 6029781 YP_001693559.1 CDS plsX NC_010380.1 112512 113504 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 112512..113504 Streptococcus pneumoniae Hungary19A-6 6027959 YP_001693560.1 CDS SPH_0138 NC_010380.1 113510 113743 D hypothetical protein 113510..113743 Streptococcus pneumoniae Hungary19A-6 6029823 YP_001693561.1 CDS SPH_0139 NC_010380.1 113786 114079 D mobile genetic element 113786..114079 Streptococcus pneumoniae Hungary19A-6 6028608 YP_001693562.1 CDS SPH_0140 NC_010380.1 114282 114512 D identified by match to protein family HMM TIGR01847; hypothetical protein 114282..114512 Streptococcus pneumoniae Hungary19A-6 6029122 YP_001693563.1 CDS SPH_0141 NC_010380.1 114515 114640 D identified by glimmer; hypothetical protein 114515..114640 Streptococcus pneumoniae Hungary19A-6 6028427 YP_001693564.1 CDS SPH_0142 NC_010380.1 115263 116156 D identified by match to protein family HMM PF01381; XRE family transcriptional regulator 115263..116156 Streptococcus pneumoniae Hungary19A-6 6029953 YP_001693565.1 CDS SPH_0143 NC_010380.1 116699 116995 D hypothetical protein 116699..116995 Streptococcus pneumoniae Hungary19A-6 6029978 YP_001693566.1 CDS SPH_0144 NC_010380.1 117002 118138 D hypothetical protein 117002..118138 Streptococcus pneumoniae Hungary19A-6 6028824 YP_001693567.1 CDS SPH_0145 NC_010380.1 118375 118617 D identified by glimmer; hypothetical protein 118375..118617 Streptococcus pneumoniae Hungary19A-6 6027936 YP_001693568.1 CDS SPH_0146 NC_010380.1 118614 119210 D identified by glimmer; hypothetical protein 118614..119210 Streptococcus pneumoniae Hungary19A-6 6029203 YP_001693569.1 CDS SPH_0147 NC_010380.1 119191 119682 D identified by glimmer; hypothetical protein 119191..119682 Streptococcus pneumoniae Hungary19A-6 6030058 YP_001693570.1 CDS SPH_0148 NC_010380.1 120062 122215 D identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193; transport/processing ATP-binding protein ComA 120062..122215 Streptococcus pneumoniae Hungary19A-6 6029866 YP_001693571.1 CDS SPH_0149 NC_010380.1 122228 123577 D identified by match to protein family HMM TIGR01000; transport protein ComB 122228..123577 Streptococcus pneumoniae Hungary19A-6 6029033 YP_001693572.1 CDS purC NC_010380.1 123746 124453 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 123746..124453 Streptococcus pneumoniae Hungary19A-6 6028631 YP_001693573.1 CDS SPH_0151 NC_010380.1 124464 124598 D phosphoribosylaminoimidazole-succinocarboxamide synthase (saicar synthetase) 124464..124598 Streptococcus pneumoniae Hungary19A-6 6029184 YP_001693574.1 CDS SPH_0152 NC_010380.1 124655 128380 D identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857; phosphoribosylformylglycinamidine synthase 124655..128380 Streptococcus pneumoniae Hungary19A-6 6027922 YP_001693575.1 CDS purF NC_010380.1 128473 129915 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 128473..129915 Streptococcus pneumoniae Hungary19A-6 6028915 YP_001693576.1 CDS purM NC_010380.1 129952 130974 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 129952..130974 Streptococcus pneumoniae Hungary19A-6 6028090 YP_001693577.1 CDS purN NC_010380.1 130971 131516 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 130971..131516 Streptococcus pneumoniae Hungary19A-6 6029194 YP_001693578.1 CDS SPH_0156 NC_010380.1 131600 132109 D identified by match to protein family HMM PF04892; teicoplanin resistance protein 131600..132109 Streptococcus pneumoniae Hungary19A-6 6029816 YP_001693579.1 CDS purH NC_010380.1 132134 133681 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 132134..133681 Streptococcus pneumoniae Hungary19A-6 6029721 YP_001693580.1 CDS purD NC_010380.1 133803 135065 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 133803..135065 Streptococcus pneumoniae Hungary19A-6 6030048 YP_001693581.1 CDS SPH_0159 NC_010380.1 135322 135438 D hypothetical protein 135322..135438 Streptococcus pneumoniae Hungary19A-6 6028382 YP_001693582.1 CDS purE NC_010380.1 135468 135956 D identified by match to protein family HMM PF00731; match to protein family HMM TIGR01162; phosphoribosylaminoimidazole carboxylase, catalytic subunit 135468..135956 Streptococcus pneumoniae Hungary19A-6 6028473 YP_001693583.1 CDS purK NC_010380.1 135943 137034 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 135943..137034 Streptococcus pneumoniae Hungary19A-6 6029259 YP_001693584.1 CDS SPH_0162 NC_010380.1 137044 137271 D hypothetical protein 137044..137271 Streptococcus pneumoniae Hungary19A-6 6028963 YP_001693585.1 CDS purB NC_010380.1 137334 138632 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 137334..138632 Streptococcus pneumoniae Hungary19A-6 6028146 YP_001693586.1 CDS SPH_0164 NC_010380.1 138687 142625 R identified by match to protein family HMM PF00728; match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-N-acetylhexosaminidase complement(138687..142625) Streptococcus pneumoniae Hungary19A-6 6029699 YP_001693587.1 CDS SPH_0165 NC_010380.1 142940 143683 R identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator complement(142940..143683) Streptococcus pneumoniae Hungary19A-6 6029403 YP_001693588.1 CDS SPH_0166 NC_010380.1 144004 145791 D identified by match to protein family HMM PF01301; match to protein family HMM PF02449; beta-galactosidase 144004..145791 Streptococcus pneumoniae Hungary19A-6 6028886 YP_001693589.1 CDS SPH_0167 NC_010380.1 145788 146264 D identified by match to protein family HMM PF03830; phosphotransferase system sugar-specific eiib component 145788..146264 Streptococcus pneumoniae Hungary19A-6 6028953 YP_001693590.1 CDS SPH_0168 NC_010380.1 146292 147197 D identified by match to protein family HMM PF03609; phosphotransferase system sugar-specific EIIC component 146292..147197 Streptococcus pneumoniae Hungary19A-6 6029050 YP_001693591.1 CDS SPH_0169 NC_010380.1 147184 147999 D identified by match to protein family HMM PF03613; PTS system, IID component 147184..147999 Streptococcus pneumoniae Hungary19A-6 6028305 YP_001693592.1 CDS SPH_0170 NC_010380.1 148006 148410 D identified by match to protein family HMM PF03610; phosphotransferase system sugar-specific EII component 148006..148410 Streptococcus pneumoniae Hungary19A-6 6029370 YP_001693593.1 CDS SPH_0171 NC_010380.1 148663 149829 D identified by match to protein family HMM PF01380; hypothetical protein 148663..149829 Streptococcus pneumoniae Hungary19A-6 6028493 YP_001693594.1 CDS SPH_0172 NC_010380.1 149945 150982 D identified by match to protein family HMM PF01263; aldose 1-epimerase 149945..150982 Streptococcus pneumoniae Hungary19A-6 6028868 YP_001693595.1 CDS SPH_0173 NC_010380.1 151189 152043 D identified by match to protein family HMM PF00903; glyoxalase 151189..152043 Streptococcus pneumoniae Hungary19A-6 6029465 YP_001693596.1 CDS SPH_0174 NC_010380.1 152193 152450 D identified by match to protein family HMM PF02583; hypothetical protein 152193..152450 Streptococcus pneumoniae Hungary19A-6 6029401 YP_001693597.1 CDS SPH_0175 NC_010380.1 152618 152854 R chlorohydrolase complement(152618..152854) Streptococcus pneumoniae Hungary19A-6 6029416 YP_001693598.1 CDS SPH_0176 NC_010380.1 153194 153313 R coenzyme A disulfide reductase complement(153194..153313) Streptococcus pneumoniae Hungary19A-6 6028553 YP_001693599.1 CDS SPH_0177 NC_010380.1 153425 154189 D identified by match to protein family HMM PF01048; phosphorylase Pnp/Udp family protein 153425..154189 Streptococcus pneumoniae Hungary19A-6 6028161 YP_001693600.1 CDS SPH_0178 NC_010380.1 154445 154585 D hypothetical protein 154445..154585 Streptococcus pneumoniae Hungary19A-6 6029681 YP_001693601.1 CDS SPH_0179 NC_010380.1 154754 156133 D identified by match to protein family HMM PF02386; Trk transporter membrane-spanning protein - K+ transport 154754..156133 Streptococcus pneumoniae Hungary19A-6 6029841 YP_001693602.1 CDS SPH_0180 NC_010380.1 156147 156812 D identified by match to protein family HMM PF02254; Trk family potassium uptake protein 156147..156812 Streptococcus pneumoniae Hungary19A-6 6029296 YP_001693603.1 CDS SPH_0181 NC_010380.1 156947 157060 D identified by glimmer; hypothetical protein 156947..157060 Streptococcus pneumoniae Hungary19A-6 6029250 YP_001693604.1 CDS SPH_0184 NC_010380.1 158254 161283 D identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; cell wall surface anchor family protein 158254..161283 Streptococcus pneumoniae Hungary19A-6 6029348 YP_001693605.1 CDS SPH_0185 NC_010380.1 161450 162148 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator SaeR 161450..162148 Streptococcus pneumoniae Hungary19A-6 6030030 YP_001693606.1 CDS SPH_0186 NC_010380.1 162145 163197 D identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; histidine kinase 162145..163197 Streptococcus pneumoniae Hungary19A-6 6028692 YP_001693607.1 CDS rpsD NC_010380.1 163392 164003 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 163392..164003 Streptococcus pneumoniae Hungary19A-6 6028486 YP_001693608.1 CDS SPH_0188 NC_010380.1 164189 164347 D transposase 164189..164347 Streptococcus pneumoniae Hungary19A-6 6029240 YP_001693609.1 CDS SPH_0189 NC_010380.1 164771 165031 D hypothetical protein 164771..165031 Streptococcus pneumoniae Hungary19A-6 6029277 YP_001693610.1 CDS SPH_0190 NC_010380.1 164985 165206 D hypothetical protein 164985..165206 Streptococcus pneumoniae Hungary19A-6 6028311 YP_001693611.1 CDS SPH_0191 NC_010380.1 165495 166454 D identified by match to protein family HMM PF00528; ABC transporter membrane-spanning permease - sugar transport 165495..166454 Streptococcus pneumoniae Hungary19A-6 6029422 YP_001693612.1 CDS SPH_0192 NC_010380.1 166468 167391 D identified by match to protein family HMM PF00528; protein LplC 166468..167391 Streptococcus pneumoniae Hungary19A-6 6029606 YP_001693613.1 CDS SPH_0193 NC_010380.1 167649 169124 D identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein 167649..169124 Streptococcus pneumoniae Hungary19A-6 6028668 YP_001693614.1 CDS SPH_0194 NC_010380.1 169396 170382 D identified by match to protein family HMM PF00581; hypothetical protein 169396..170382 Streptococcus pneumoniae Hungary19A-6 6029731 YP_001693615.1 CDS SPH_0195 NC_010380.1 170504 171223 D identified by glimmer; hypothetical protein 170504..171223 Streptococcus pneumoniae Hungary19A-6 6028918 YP_001693616.1 CDS SPH_0196 NC_010380.1 171502 172566 R hypothetical protein complement(171502..172566) Streptococcus pneumoniae Hungary19A-6 6028605 YP_001693617.1 CDS SPH_0197 NC_010380.1 172629 173540 R hypothetical protein complement(172629..173540) Streptococcus pneumoniae Hungary19A-6 6029720 YP_001693618.1 CDS SPH_0198 NC_010380.1 173533 174126 R hypothetical protein complement(173533..174126) Streptococcus pneumoniae Hungary19A-6 6029779 YP_001693619.1 CDS SPH_0199 NC_010380.1 174113 174439 R identified by match to protein family HMM PF03551; transcription regulator complement(174113..174439) Streptococcus pneumoniae Hungary19A-6 6029437 YP_001693620.1 CDS SPH_0200 NC_010380.1 174578 175744 R identified by match to protein family HMM PF07690; cyanate permease complement(174578..175744) Streptococcus pneumoniae Hungary19A-6 6028743 YP_001693621.1 CDS SPH_0201 NC_010380.1 175895 176959 D identified by match to protein family HMM PF00535; glycosyl transferase 175895..176959 Streptococcus pneumoniae Hungary19A-6 6028484 YP_001693622.1 CDS SPH_0202 NC_010380.1 177001 178851 D identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; CapD protein, required for the biosynthesis of type 1 capsular polysaccharide 177001..178851 Streptococcus pneumoniae Hungary19A-6 6028467 YP_001693623.1 CDS SPH_0203 NC_010380.1 178971 179087 D identified by glimmer; hypothetical protein 178971..179087 Streptococcus pneumoniae Hungary19A-6 6029614 YP_001693624.1 CDS SPH_0204 NC_010380.1 179112 179744 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; phosphoglycolate phosphatase complement(179112..179744) Streptococcus pneumoniae Hungary19A-6 6029969 YP_001693625.1 CDS sdaAA NC_010380.1 179766 180638 R identified by match to protein family HMM PF03313; match to protein family HMM TIGR00718; L-serine dehydratase, iron-sulfur-dependent, alpha subunit complement(179766..180638) Streptococcus pneumoniae Hungary19A-6 6029340 YP_001693626.1 CDS sdaAB NC_010380.1 180647 181318 R identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719; L-serine dehydratase, iron-sulfur-dependent, beta subunit complement(180647..181318) Streptococcus pneumoniae Hungary19A-6 6029013 YP_001693627.1 CDS SPH_0207 NC_010380.1 181560 182147 D identified by match to protein family HMM PF01476; LysM domain-containing protein 181560..182147 Streptococcus pneumoniae Hungary19A-6 6029682 YP_001693628.1 CDS SPH_0208 NC_010380.1 182199 183062 R identified by match to protein family HMM PF01381; helix-turn-helix domain-containing protein complement(182199..183062) Streptococcus pneumoniae Hungary19A-6 6028375 YP_001693629.1 CDS SPH_0209 NC_010380.1 183226 183339 D hypothetical protein 183226..183339 Streptococcus pneumoniae Hungary19A-6 6029956 YP_001693630.1 CDS SPH_0210 NC_010380.1 183385 183972 D identified by glimmer; hypothetical protein 183385..183972 Streptococcus pneumoniae Hungary19A-6 6028643 YP_001693631.1 CDS SPH_0211 NC_010380.1 184385 184633 D identified by match to protein family HMM TIGR01653; bacteriocin 184385..184633 Streptococcus pneumoniae Hungary19A-6 6029901 YP_001693632.1 CDS SPH_0212 NC_010380.1 184688 186796 D identified by match to protein family HMM TIGR01654; ABC transporter membrane-spanning permease - amino acid transport 184688..186796 Streptococcus pneumoniae Hungary19A-6 6029536 YP_001693633.1 CDS SPH_0213 NC_010380.1 186793 187434 D identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease MacB 186793..187434 Streptococcus pneumoniae Hungary19A-6 6029282 YP_001693634.1 CDS SPH_0214 NC_010380.1 187641 188447 D identified by match to protein family HMM PF00497; ABC transporter solute-binding protein - amino acid transport 187641..188447 Streptococcus pneumoniae Hungary19A-6 6027764 YP_001693635.1 CDS argG NC_010380.1 188464 189660 D catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 188464..189660 Streptococcus pneumoniae Hungary19A-6 6029570 YP_001693636.1 CDS argH NC_010380.1 189689 191080 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 189689..191080 Streptococcus pneumoniae Hungary19A-6 6029814 YP_001693637.1 CDS SPH_0217 NC_010380.1 191369 191584 R hypothetical protein complement(191369..191584) Streptococcus pneumoniae Hungary19A-6 6030074 YP_001693638.1 CDS SPH_0218 NC_010380.1 192447 192818 D hypothetical protein 192447..192818 Streptococcus pneumoniae Hungary19A-6 6029936 YP_001693639.1 CDS SPH_0219 NC_010380.1 192826 193038 D hypothetical protein 192826..193038 Streptococcus pneumoniae Hungary19A-6 6028122 YP_001693640.1 CDS SPH_0220 NC_010380.1 193412 193537 D hypothetical protein 193412..193537 Streptococcus pneumoniae Hungary19A-6 6028209 YP_001693641.1 CDS SPH_0221 NC_010380.1 193518 193655 D identified by glimmer; hypothetical protein 193518..193655 Streptococcus pneumoniae Hungary19A-6 6030065 YP_001693642.1 CDS SPH_0222 NC_010380.1 193843 194901 D hypothetical protein 193843..194901 Streptococcus pneumoniae Hungary19A-6 6028754 YP_001693643.1 CDS SPH_0223 NC_010380.1 195216 196193 D identified by glimmer; hypothetical protein 195216..196193 Streptococcus pneumoniae Hungary19A-6 6029988 YP_001693644.1 CDS SPH_0224 NC_010380.1 196665 197039 D hypothetical protein 196665..197039 Streptococcus pneumoniae Hungary19A-6 6029820 YP_001693645.1 CDS SPH_0225 NC_010380.1 197046 197228 D hypothetical protein 197046..197228 Streptococcus pneumoniae Hungary19A-6 6029460 YP_001693646.1 CDS SPH_0226 NC_010380.1 197247 198149 D hypothetical protein 197247..198149 Streptococcus pneumoniae Hungary19A-6 6029288 YP_001693647.1 CDS SPH_0227 NC_010380.1 198205 198558 D hypothetical protein 198205..198558 Streptococcus pneumoniae Hungary19A-6 6030011 YP_001693648.1 CDS SPH_0228 NC_010380.1 198555 199283 D hypothetical protein 198555..199283 Streptococcus pneumoniae Hungary19A-6 6029557 YP_001693649.1 CDS SPH_0229 NC_010380.1 200515 200658 D hypothetical protein 200515..200658 Streptococcus pneumoniae Hungary19A-6 6029107 YP_001693650.1 CDS SPH_0230 NC_010380.1 200673 200990 R identified by glimmer; hypothetical protein complement(200673..200990) Streptococcus pneumoniae Hungary19A-6 6027855 YP_001693651.1 CDS SPH_0231 NC_010380.1 200944 201084 D identified by glimmer; hypothetical protein 200944..201084 Streptococcus pneumoniae Hungary19A-6 6029071 YP_001693652.1 CDS SPH_0232 NC_010380.1 201209 203326 D identified by match to protein family HMM PF01473; hypothetical protein 201209..203326 Streptococcus pneumoniae Hungary19A-6 6027778 YP_001693653.1 CDS SPH_0233 NC_010380.1 203567 203704 D identified by glimmer; hypothetical protein 203567..203704 Streptococcus pneumoniae Hungary19A-6 6028579 YP_001693654.1 CDS mnmA NC_010380.1 203726 204847 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 203726..204847 Streptococcus pneumoniae Hungary19A-6 6027696 YP_001693655.1 CDS SPH_0235 NC_010380.1 204988 205443 D identified by match to protein family HMM PF00293; MutT/nudix family protein 204988..205443 Streptococcus pneumoniae Hungary19A-6 6029999 YP_001693656.1 CDS gidA NC_010380.1 205453 207366 D GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 205453..207366 Streptococcus pneumoniae Hungary19A-6 6028234 YP_001693657.1 CDS SPH_0237 NC_010380.1 207745 209424 R identified by match to protein family HMM PF00753; match to protein family HMM PF07521; match to protein family HMM TIGR00649; metallo-beta-lactamase superfamily protein complement(207745..209424) Streptococcus pneumoniae Hungary19A-6 6028989 YP_001693658.1 CDS SPH_0238 NC_010380.1 209426 209659 R identified by match to protein family HMM PF07288; hypothetical protein complement(209426..209659) Streptococcus pneumoniae Hungary19A-6 6028778 YP_001693659.1 CDS SPH_0239 NC_010380.1 209985 210230 R identified by glimmer; hypothetical protein complement(209985..210230) Streptococcus pneumoniae Hungary19A-6 6028812 YP_001693660.1 CDS SPH_0240 NC_010380.1 210477 210629 R identified by match to protein family HMM TIGR01847; bacteriocin-type signal sequence domain-containing protein complement(210477..210629) Streptococcus pneumoniae Hungary19A-6 6027859 YP_001693661.1 CDS SPH_0241 NC_010380.1 210631 210816 R hypothetical protein complement(210631..210816) Streptococcus pneumoniae Hungary19A-6 6029173 YP_001693662.1 CDS SPH_0242 NC_010380.1 210994 211677 D identified by match to protein family HMM PF00814; glycoprotein endopeptidase 210994..211677 Streptococcus pneumoniae Hungary19A-6 6029589 YP_001693663.1 CDS rimI NC_010380.1 211674 212111 D identified by match to protein family HMM PF00583; match to protein family HMM TIGR01575; ribosomal-protein-alanine acetyltransferase 211674..212111 Streptococcus pneumoniae Hungary19A-6 6027983 YP_001693664.1 CDS SPH_0244 NC_010380.1 212101 213111 D in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 212101..213111 Streptococcus pneumoniae Hungary19A-6 6028717 YP_001693665.1 CDS SPH_0247 NC_010380.1 215164 215367 R degenerative transposase complement(215164..215367) Streptococcus pneumoniae Hungary19A-6 6027818 YP_001693666.1 CDS SPH_0248 NC_010380.1 215718 216932 D identified by match to protein family HMM PF00534; glycosyl transferase, group 1 family protein 215718..216932 Streptococcus pneumoniae Hungary19A-6 6028365 YP_001693667.1 CDS SPH_0249 NC_010380.1 216925 217878 D identified by match to protein family HMM PF00535; glycosyl transferase 216925..217878 Streptococcus pneumoniae Hungary19A-6 6028995 YP_001693668.1 CDS SPH_0250 NC_010380.1 217888 219504 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 217888..219504 Streptococcus pneumoniae Hungary19A-6 6028776 YP_001693669.1 CDS SPH_0251 NC_010380.1 220205 220855 D identified by glimmer; hypothetical protein 220205..220855 Streptococcus pneumoniae Hungary19A-6 6028821 YP_001693670.1 CDS SPH_0252 NC_010380.1 220966 222138 D identified by match to protein family HMM PF00984; match to protein family HMM PF03721; match to protein family HMM TIGR03026; UDP-glucose 6-dehydrogenase 220966..222138 Streptococcus pneumoniae Hungary19A-6 6028987 YP_001693671.1 CDS SPH_0253 NC_010380.1 222533 223396 D identified by match to protein family HMM TIGR01716; MutR 222533..223396 Streptococcus pneumoniae Hungary19A-6 6029558 YP_001693672.1 CDS SPH_0254 NC_010380.1 223687 223884 D identified by glimmer; hypothetical protein 223687..223884 Streptococcus pneumoniae Hungary19A-6 6028667 YP_001693673.1 CDS SPH_0255 NC_010380.1 223952 224617 D identified by match to protein family HMM PF02517; CAAX amino protease 223952..224617 Streptococcus pneumoniae Hungary19A-6 6029448 YP_001693674.1 CDS SPH_0256 NC_010380.1 224689 225915 D identified by match to protein family HMM PF07690; transporter major facilitator family protein 224689..225915 Streptococcus pneumoniae Hungary19A-6 6028172 YP_001693675.1 CDS SPH_0257 NC_010380.1 226191 226478 R identified by glimmer; hypothetical protein complement(226191..226478) Streptococcus pneumoniae Hungary19A-6 6029870 YP_001693676.1 CDS SPH_0258 NC_010380.1 226549 227205 D identified by match to protein family HMM PF03591; branched-chain amino acid permease 226549..227205 Streptococcus pneumoniae Hungary19A-6 6028576 YP_001693677.1 CDS SPH_0259 NC_010380.1 227195 227518 D identified by match to protein family HMM PF05437; branched-chain amino acid transport protein AzlD 227195..227518 Streptococcus pneumoniae Hungary19A-6 6027951 YP_001693678.1 CDS SPH_0260 NC_010380.1 227622 228452 D identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein - amino acid transport 227622..228452 Streptococcus pneumoniae Hungary19A-6 6029609 YP_001693679.1 CDS SPH_0261 NC_010380.1 228606 229460 D identified by match to protein family HMM PF03180; lipoprotein 228606..229460 Streptococcus pneumoniae Hungary19A-6 6028310 YP_001693680.1 CDS SPH_0262 NC_010380.1 229560 230933 D identified by match to protein family HMM PF01546; match to protein family HMM PF07687; acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase 229560..230933 Streptococcus pneumoniae Hungary19A-6 6028133 YP_001693681.1 CDS SPH_0263 NC_010380.1 230926 231987 D identified by match to protein family HMM PF00005; methionine import ATP-binding protein MetN 230926..231987 Streptococcus pneumoniae Hungary19A-6 6028901 YP_001693682.1 CDS SPH_0264 NC_010380.1 231989 232681 D identified by match to protein family HMM PF00528; ABC transporter permease 231989..232681 Streptococcus pneumoniae Hungary19A-6 6027711 YP_001693683.1 CDS SPH_0265 NC_010380.1 232711 233280 R identified by match to protein family HMM TIGR02185; membrane-bound protein complement(232711..233280) Streptococcus pneumoniae Hungary19A-6 6029568 YP_001693684.1 CDS SPH_0266 NC_010380.1 233415 234029 D identified by match to protein family HMM PF04854; hypothetical protein 233415..234029 Streptococcus pneumoniae Hungary19A-6 6029949 YP_001693685.1 CDS SPH_0267 NC_010380.1 234079 235677 D identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF06580; sensor histidine kinase 234079..235677 Streptococcus pneumoniae Hungary19A-6 6027839 YP_001693686.1 CDS SPH_0268 NC_010380.1 235689 236975 D identified by match to protein family HMM PF00072; match to protein family HMM PF00165; response regulator 235689..236975 Streptococcus pneumoniae Hungary19A-6 6027726 YP_001693687.1 CDS SPH_0269 NC_010380.1 237027 237560 D hypothetical protein 237027..237560 Streptococcus pneumoniae Hungary19A-6 6029528 YP_001693688.1 CDS SPH_0271 NC_010380.1 237638 238108 D has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; flavoprotein NrdI 237638..238108 Streptococcus pneumoniae Hungary19A-6 6028843 YP_001693689.1 CDS SPH_0270 NC_010380.1 238105 238236 R hypothetical protein complement(238105..238236) Streptococcus pneumoniae Hungary19A-6 6029335 YP_001693690.1 CDS SPH_0272 NC_010380.1 238414 239760 R identified by match to protein family HMM PF01609; Spn1 transposase complement(238414..239760) Streptococcus pneumoniae Hungary19A-6 6028403 YP_001693691.1 CDS SPH_0273 NC_010380.1 240110 241372 R manganese transporter NRAMP complement(240110..241372) Streptococcus pneumoniae Hungary19A-6 6028767 YP_001693692.1 CDS SPH_0274 NC_010380.1 241682 242140 R hypothetical protein complement(241682..242140) Streptococcus pneumoniae Hungary19A-6 6028269 YP_001693693.1 CDS SPH_0275 NC_010380.1 242137 242577 R identified by match to protein family HMM PF04397; response regulator complement(242137..242577) Streptococcus pneumoniae Hungary19A-6 6028465 YP_001693694.1 CDS SPH_0276 NC_010380.1 242665 242790 R identified by glimmer; hypothetical protein complement(242665..242790) Streptococcus pneumoniae Hungary19A-6 6029933 YP_001693695.1 CDS mutL NC_010380.1 242933 244882 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 242933..244882 Streptococcus pneumoniae Hungary19A-6 6029678 YP_001693696.1 CDS ribH NC_010380.1 245207 245674 R RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase complement(245207..245674) Streptococcus pneumoniae Hungary19A-6 6028494 YP_001693697.1 CDS SPH_0279 NC_010380.1 245675 246880 R identified by match to protein family HMM PF00925; match to protein family HMM PF00926; match to protein family HMM TIGR00505; match to protein family HMM TIGR00506; riboflavin biosynthesis protein ribAB complement(245675..246880) Streptococcus pneumoniae Hungary19A-6 6027695 YP_001693698.1 CDS ribE NC_010380.1 246900 247535 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(246900..247535) Streptococcus pneumoniae Hungary19A-6 6028687 YP_001693699.1 CDS ribD NC_010380.1 247520 248620 R identified by match to protein family HMM PF00383; match to protein family HMM PF01872; match to protein family HMM TIGR00227; match to protein family HMM TIGR00326; riboflavin biosynthesis protein RibD complement(247520..248620) Streptococcus pneumoniae Hungary19A-6 6028879 YP_001693700.1 CDS ruvA NC_010380.1 249025 249618 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 249025..249618 Streptococcus pneumoniae Hungary19A-6 6030021 YP_001693701.1 CDS SPH_0283 NC_010380.1 249628 250191 D identified by match to protein family HMM PF03352; DNA-3-methyladenine glycosylase 1 249628..250191 Streptococcus pneumoniae Hungary19A-6 6029576 YP_001693702.1 CDS SPH_0284 NC_010380.1 250188 250865 D identified by match to protein family HMM PF02517; CAAX amino protease 250188..250865 Streptococcus pneumoniae Hungary19A-6 6027831 YP_001693703.1 CDS SPH_0285 NC_010380.1 251002 252033 R identified by match to protein family HMM PF02016; MccC family protein complement(251002..252033) Streptococcus pneumoniae Hungary19A-6 6027985 YP_001693704.1 CDS SPH_0286 NC_010380.1 252094 252246 D hypothetical protein 252094..252246 Streptococcus pneumoniae Hungary19A-6 6029182 YP_001693705.1 CDS SPH_0287 NC_010380.1 252288 252971 R identified by match to protein family HMM PF06570; hypothetical protein complement(252288..252971) Streptococcus pneumoniae Hungary19A-6 6028920 YP_001693706.1 CDS SPH_0288 NC_010380.1 252983 253927 R identified by match to protein family HMM PF01544; magnesium and cobalt transporter complement(252983..253927) Streptococcus pneumoniae Hungary19A-6 6028792 YP_001693707.1 CDS SPH_0289 NC_010380.1 254088 255254 R identified by match to protein family HMM PF00589; prophage Sa05, site-specific recombinase phage integrase complement(254088..255254) Streptococcus pneumoniae Hungary19A-6 6029333 YP_001693708.1 CDS SPH_0290 NC_010380.1 255339 256853 R identified by match to protein family HMM PF04326; ATPase AAA complement(255339..256853) Streptococcus pneumoniae Hungary19A-6 6029452 YP_001693709.1 CDS SPH_0291 NC_010380.1 257014 257727 R identified by match to protein family HMM PF01381; DNA-binding phage protein complement(257014..257727) Streptococcus pneumoniae Hungary19A-6 6029585 YP_001693710.1 CDS SPH_0292 NC_010380.1 257928 258065 D hypothetical protein 257928..258065 Streptococcus pneumoniae Hungary19A-6 6029130 YP_001693711.1 CDS SPH_0293 NC_010380.1 258125 258751 D hypothetical protein 258125..258751 Streptococcus pneumoniae Hungary19A-6 6028752 YP_001693712.1 CDS SPH_0294 NC_010380.1 259225 259575 D hypothetical protein 259225..259575 Streptococcus pneumoniae Hungary19A-6 6029942 YP_001693713.1 CDS SPH_0295 NC_010380.1 259572 259772 D hypothetical protein 259572..259772 Streptococcus pneumoniae Hungary19A-6 6029869 YP_001693714.1 CDS SPH_0296 NC_010380.1 259774 259989 D hypothetical protein 259774..259989 Streptococcus pneumoniae Hungary19A-6 6028121 YP_001693715.1 CDS SPH_0297 NC_010380.1 259986 260327 D phage protein 259986..260327 Streptococcus pneumoniae Hungary19A-6 6027804 YP_001693716.1 CDS SPH_0298 NC_010380.1 260320 260601 D phage protein 260320..260601 Streptococcus pneumoniae Hungary19A-6 6028296 YP_001693717.1 CDS SPH_0299 NC_010380.1 260736 261602 D identified by match to protein family HMM PF08708; phage protein 260736..261602 Streptococcus pneumoniae Hungary19A-6 6028822 YP_001693718.1 CDS SPH_0300 NC_010380.1 261655 263124 D identified by match to protein family HMM PF08706; match to protein family HMM TIGR01613; prophage Sa05, P4 family DNA primase 261655..263124 Streptococcus pneumoniae Hungary19A-6 6028348 YP_001693719.1 CDS SPH_0301 NC_010380.1 263487 263654 D identified by glimmer; hypothetical protein 263487..263654 Streptococcus pneumoniae Hungary19A-6 6027950 YP_001693720.1 CDS SPH_0302 NC_010380.1 263738 264268 D phage protein 263738..264268 Streptococcus pneumoniae Hungary19A-6 6028672 YP_001693721.1 CDS SPH_0303 NC_010380.1 264339 264848 D hypothetical protein 264339..264848 Streptococcus pneumoniae Hungary19A-6 6029884 YP_001693722.1 CDS SPH_0304 NC_010380.1 266055 266474 D identified by match to protein family HMM PF08281; phage protein 266055..266474 Streptococcus pneumoniae Hungary19A-6 6030060 YP_001693723.1 CDS uvrA NC_010380.1 266963 269794 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 266963..269794 Streptococcus pneumoniae Hungary19A-6 6029145 YP_001693724.1 CDS SPH_0306 NC_010380.1 269787 270848 D identified by match to protein family HMM PF00557; match to protein family HMM PF01321; Xaa-Pro dipeptidase 269787..270848 Streptococcus pneumoniae Hungary19A-6 6028059 YP_001693725.1 CDS spxA NC_010380.1 270980 271378 D the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 270980..271378 Streptococcus pneumoniae Hungary19A-6 6027995 YP_001693726.1 CDS SPH_0308 NC_010380.1 271444 272013 D lipoprotein 271444..272013 Streptococcus pneumoniae Hungary19A-6 6028154 YP_001693727.1 CDS SPH_0309 NC_010380.1 272100 272366 D identified by match to protein family HMM PF06135; hypothetical protein 272100..272366 Streptococcus pneumoniae Hungary19A-6 6029786 YP_001693728.1 CDS SPH_0310 NC_010380.1 272370 272789 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 272370..272789 Streptococcus pneumoniae Hungary19A-6 6030080 YP_001693729.1 CDS SPH_0311 NC_010380.1 272805 273110 D identified by match to protein family HMM PF06949; hypothetical protein 272805..273110 Streptococcus pneumoniae Hungary19A-6 6029445 YP_001693730.1 CDS SPH_0312 NC_010380.1 273247 273372 R identified by glimmer; hypothetical protein complement(273247..273372) Streptococcus pneumoniae Hungary19A-6 6028037 YP_001693731.1 CDS SPH_0313 NC_010380.1 273523 274773 D identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; dihydrofolate:folylpolyglutamate synthetase 273523..274773 Streptococcus pneumoniae Hungary19A-6 6027843 YP_001693732.1 CDS SPH_0314 NC_010380.1 274857 275312 D lipoprotein 274857..275312 Streptococcus pneumoniae Hungary19A-6 6029374 YP_001693733.1 CDS SPH_0315 NC_010380.1 275458 276990 D identified by match to protein family HMM PF00614; cardiolipin synthase 275458..276990 Streptococcus pneumoniae Hungary19A-6 6030051 YP_001693734.1 CDS SPH_0316 NC_010380.1 277248 278786 D competence-induced protein Ccs4 277248..278786 Streptococcus pneumoniae Hungary19A-6 6028257 YP_001693735.1 CDS nrdD NC_010380.1 278906 281113 D Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 278906..281113 Streptococcus pneumoniae Hungary19A-6 6027879 YP_001693736.1 CDS SPH_0318 NC_010380.1 281125 281265 D hypothetical protein 281125..281265 Streptococcus pneumoniae Hungary19A-6 6029641 YP_001693737.1 CDS SPH_0319 NC_010380.1 281309 281815 D identified by match to protein family HMM PF00583; acetyltransferase 281309..281815 Streptococcus pneumoniae Hungary19A-6 6028354 YP_001693738.1 CDS nrdG NC_010380.1 281808 282398 D identified by match to protein family HMM PF04055; match to protein family HMM TIGR02491; anaerobic ribonucleoside-triphosphate reductase activating protein 281808..282398 Streptococcus pneumoniae Hungary19A-6 6029481 YP_001693739.1 CDS SPH_0321 NC_010380.1 282395 283012 D identified by match to protein family HMM PF00485; phosphoribulokinase/uridine kinase 282395..283012 Streptococcus pneumoniae Hungary19A-6 6029852 YP_001693740.1 CDS rpsJ NC_010380.1 283279 283587 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 283279..283587 Streptococcus pneumoniae Hungary19A-6 6029192 YP_001693741.1 CDS rplC NC_010380.1 283804 284430 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 283804..284430 Streptococcus pneumoniae Hungary19A-6 6028458 YP_001693742.1 CDS rplD NC_010380.1 284455 285078 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 284455..285078 Streptococcus pneumoniae Hungary19A-6 6029670 YP_001693743.1 CDS rplW NC_010380.1 285078 285374 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 285078..285374 Streptococcus pneumoniae Hungary19A-6 6028187 YP_001693744.1 CDS rplB NC_010380.1 285392 286225 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 285392..286225 Streptococcus pneumoniae Hungary19A-6 6029762 YP_001693745.1 CDS rpsS NC_010380.1 286329 286610 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 286329..286610 Streptococcus pneumoniae Hungary19A-6 6028674 YP_001693746.1 CDS rplV NC_010380.1 286622 286966 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 286622..286966 Streptococcus pneumoniae Hungary19A-6 6027968 YP_001693747.1 CDS rpsC NC_010380.1 286979 287632 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 286979..287632 Streptococcus pneumoniae Hungary19A-6 6027890 YP_001693748.1 CDS rplP NC_010380.1 287636 288049 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 287636..288049 Streptococcus pneumoniae Hungary19A-6 6029750 YP_001693749.1 CDS rpmC NC_010380.1 288059 288265 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 288059..288265 Streptococcus pneumoniae Hungary19A-6 6028357 YP_001693750.1 CDS rpsQ NC_010380.1 288290 288550 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 288290..288550 Streptococcus pneumoniae Hungary19A-6 6028217 YP_001693751.1 CDS rplN NC_010380.1 288576 288944 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 288576..288944 Streptococcus pneumoniae Hungary19A-6 6030069 YP_001693752.1 CDS rplX NC_010380.1 288991 289326 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 288991..289326 Streptococcus pneumoniae Hungary19A-6 6028702 YP_001693753.1 CDS rplE NC_010380.1 289350 289892 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 289350..289892 Streptococcus pneumoniae Hungary19A-6 6027763 YP_001693754.1 CDS rpsN NC_010380.1 289910 290179 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 289910..290179 Streptococcus pneumoniae Hungary19A-6 6029364 YP_001693755.1 CDS rpsH NC_010380.1 290464 290862 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 290464..290862 Streptococcus pneumoniae Hungary19A-6 6028260 YP_001693756.1 CDS rplF NC_010380.1 291054 291590 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 291054..291590 Streptococcus pneumoniae Hungary19A-6 6028507 YP_001693757.1 CDS rplR NC_010380.1 291674 292030 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 291674..292030 Streptococcus pneumoniae Hungary19A-6 6028228 YP_001693758.1 CDS rpsE NC_010380.1 292048 292542 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 292048..292542 Streptococcus pneumoniae Hungary19A-6 6029791 YP_001693759.1 CDS rpmD NC_010380.1 292556 292738 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 292556..292738 Streptococcus pneumoniae Hungary19A-6 6029809 YP_001693760.1 CDS rplO NC_010380.1 292883 293323 D late assembly protein; 50S ribosomal protein L15 292883..293323 Streptococcus pneumoniae Hungary19A-6 6027815 YP_001693761.1 CDS secY NC_010380.1 293336 294646 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 293336..294646 Streptococcus pneumoniae Hungary19A-6 6029549 YP_001693762.1 CDS adk NC_010380.1 294797 295435 D ATP-AMP transphosphorylase; AK; Superoxide-inducible protein 16; SOI16; essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 294797..295435 Streptococcus pneumoniae Hungary19A-6 6029084 YP_001693763.1 CDS infA NC_010380.1 295552 295770 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 295552..295770 Streptococcus pneumoniae Hungary19A-6 6028380 YP_001693764.1 CDS rpmJ NC_010380.1 295795 295911 D smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 295795..295911 Streptococcus pneumoniae Hungary19A-6 6027872 YP_001693765.1 CDS rpsM NC_010380.1 295929 296294 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 295929..296294 Streptococcus pneumoniae Hungary19A-6 6028178 YP_001693766.1 CDS rpsK NC_010380.1 296312 296695 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 296312..296695 Streptococcus pneumoniae Hungary19A-6 6029217 YP_001693767.1 CDS rpoA NC_010380.1 296738 297673 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 296738..297673 Streptococcus pneumoniae Hungary19A-6 6028189 YP_001693768.1 CDS rplQ NC_010380.1 297685 298071 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 297685..298071 Streptococcus pneumoniae Hungary19A-6 6028983 YP_001693769.1 CDS SPH_0351 NC_010380.1 298336 298602 D ACT domain-containing protein; hypothetical protein 298336..298602 Streptococcus pneumoniae Hungary19A-6 6027774 YP_001693770.1 CDS SPH_0352 NC_010380.1 298612 299949 D identified by match to protein family HMM PF05167; hypothetical protein 298612..299949 Streptococcus pneumoniae Hungary19A-6 6029642 YP_001693771.1 CDS SPH_0353 NC_010380.1 300239 300931 D identified by match to protein family HMM PF00300; phosphoglycerate mutase 300239..300931 Streptococcus pneumoniae Hungary19A-6 6028964 YP_001693772.1 CDS SPH_0356 NC_010380.1 302676 303767 R identified by match to protein family HMM PF00005; match to protein family HMM PF08402; lactose transport ATP-binding protein LacK complement(302676..303767) Streptococcus pneumoniae Hungary19A-6 6027813 YP_001693773.1 CDS SPH_0362 NC_010380.1 305873 306256 R two-component sensor kinase YesM complement(305873..306256) Streptococcus pneumoniae Hungary19A-6 6027969 YP_001693774.1 CDS SPH_0363 NC_010380.1 306589 307365 R identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494; pyruvate formate-lyase 3 complement(306589..307365) Streptococcus pneumoniae Hungary19A-6 6029532 YP_001693775.1 CDS SPH_0364 NC_010380.1 307488 308234 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; HTH-type transcriptional regulator YciT 307488..308234 Streptococcus pneumoniae Hungary19A-6 6029765 YP_001693776.1 CDS SPH_0365 NC_010380.1 308247 309227 D identified by match to protein family HMM PF04198; transcriptional regulator 308247..309227 Streptococcus pneumoniae Hungary19A-6 6029280 YP_001693777.1 CDS SPH_0366 NC_010380.1 309422 309742 D identified by match to protein family HMM PF02255; phosphotransferase system sugar-specific EIIA component 309422..309742 Streptococcus pneumoniae Hungary19A-6 6029732 YP_001693778.1 CDS SPH_0367 NC_010380.1 309788 310096 D identified by match to protein family HMM PF02302; phosphotransferase system sugar-specific eiib component 309788..310096 Streptococcus pneumoniae Hungary19A-6 6029656 YP_001693779.1 CDS SPH_0368 NC_010380.1 310113 311411 D pts system lichenan-specific eiiccomponent; eiic-lic; identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; lichenan permease IIC component 310113..311411 Streptococcus pneumoniae Hungary19A-6 6029039 YP_001693780.1 CDS SPH_0369 NC_010380.1 311562 314000 D identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01774; pyruvate formate-lyase 311562..314000 Streptococcus pneumoniae Hungary19A-6 6028381 YP_001693781.1 CDS SPH_0370 NC_010380.1 314019 314687 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 314019..314687 Streptococcus pneumoniae Hungary19A-6 6029478 YP_001693782.1 CDS gldA NC_010380.1 314705 315793 D forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 314705..315793 Streptococcus pneumoniae Hungary19A-6 6029764 YP_001693783.1 CDS leuS NC_010380.1 316248 318749 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 316248..318749 Streptococcus pneumoniae Hungary19A-6 6028274 YP_001693784.1 CDS SPH_0373 NC_010380.1 318888 319730 D identified by glimmer; hypothetical protein 318888..319730 Streptococcus pneumoniae Hungary19A-6 6029385 YP_001693785.1 CDS SPH_0374 NC_010380.1 319786 320481 D identified by match to protein family HMM PF00583; acetyltransferase 319786..320481 Streptococcus pneumoniae Hungary19A-6 6027893 YP_001693786.1 CDS SPH_0375 NC_010380.1 320493 320909 D identified by match to protein family HMM PF00583; acetyltransferase 320493..320909 Streptococcus pneumoniae Hungary19A-6 6029354 YP_001693787.1 CDS ruvB NC_010380.1 321950 322948 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 321950..322948 Streptococcus pneumoniae Hungary19A-6 6029855 YP_001693788.1 CDS SPH_0377 NC_010380.1 322929 323501 D identified by match to protein family HMM PF06042; hypothetical protein 322929..323501 Streptococcus pneumoniae Hungary19A-6 6028970 YP_001693789.1 CDS uppS NC_010380.1 323732 324490 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 323732..324490 Streptococcus pneumoniae Hungary19A-6 6029594 YP_001693790.1 CDS cdsA NC_010380.1 324499 325302 D identified by match to protein family HMM PF01148; phosphatidate cytidylyltransferase 324499..325302 Streptococcus pneumoniae Hungary19A-6 6029175 YP_001693791.1 CDS rseP NC_010380.1 325324 326583 D identified by match to protein family HMM PF02163; match to protein family HMM TIGR00054; RIP metalloprotease RseP 325324..326583 Streptococcus pneumoniae Hungary19A-6 6028872 YP_001693792.1 CDS proS NC_010380.1 326596 328449 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 326596..328449 Streptococcus pneumoniae Hungary19A-6 6028077 YP_001693793.1 CDS SPH_0382 NC_010380.1 328548 329927 D identified by match to protein family HMM PF00232; glycosy hydrolase 328548..329927 Streptococcus pneumoniae Hungary19A-6 6030038 YP_001693794.1 CDS glmS NC_010380.1 330119 331927 D Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 330119..331927 Streptococcus pneumoniae Hungary19A-6 6029366 YP_001693795.1 CDS SPH_0384 NC_010380.1 331947 332141 R chlorohydrolase complement(331947..332141) Streptococcus pneumoniae Hungary19A-6 6029294 YP_001693796.1 CDS SPH_0385 NC_010380.1 332198 333247 D identified by match to protein family HMM PF00296; oxidoreductase 332198..333247 Streptococcus pneumoniae Hungary19A-6 6028272 YP_001693797.1 CDS SPH_0386 NC_010380.1 333347 337210 R identified by match to protein family HMM PF00128; match to protein family HMM PF00746; match to protein family HMM PF02922; match to protein family HMM PF03714; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; match to protein family HMM TIGR02102; pullulanase, extracellular complement(333347..337210) Streptococcus pneumoniae Hungary19A-6 6027942 YP_001693798.1 CDS rpsL NC_010380.1 337627 338040 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 337627..338040 Streptococcus pneumoniae Hungary19A-6 6028351 YP_001693799.1 CDS rpsG NC_010380.1 338060 338530 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 338060..338530 Streptococcus pneumoniae Hungary19A-6 6029055 YP_001693800.1 CDS fusA NC_010380.1 338955 341036 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 338955..341036 Streptococcus pneumoniae Hungary19A-6 6028053 YP_001693801.1 CDS polC NC_010380.1 341140 345531 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 341140..345531 Streptococcus pneumoniae Hungary19A-6 6029707 YP_001693802.1 CDS SPH_0391 NC_010380.1 345633 345896 D identified by match to protein family HMM PF04221; match to protein family HMM TIGR02384; addiction module antitoxin 345633..345896 Streptococcus pneumoniae Hungary19A-6 6029397 YP_001693803.1 CDS SPH_0392 NC_010380.1 345889 346167 D identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; DNA damage inducible protein 345889..346167 Streptococcus pneumoniae Hungary19A-6 6029392 YP_001693804.1 CDS SPH_0393 NC_010380.1 346188 346340 D hypothetical protein 346188..346340 Streptococcus pneumoniae Hungary19A-6 6028909 YP_001693805.1 CDS SPH_0394 NC_010380.1 346362 347603 D identified by match to protein family HMM PF02073; aminopeptidase 346362..347603 Streptococcus pneumoniae Hungary19A-6 6029830 YP_001693806.1 CDS SPH_0395 NC_010380.1 347657 348637 R identified by match to protein family HMM PF01844; HNH endonuclease domain-containing protein complement(347657..348637) Streptococcus pneumoniae Hungary19A-6 6029183 YP_001693807.1 CDS SPH_0396 NC_010380.1 348752 349474 D identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; RNA pseudouridine synthase 348752..349474 Streptococcus pneumoniae Hungary19A-6 6029429 YP_001693808.1 CDS SPH_0397 NC_010380.1 349586 350920 D identified by match to protein family HMM PF03051; aminopeptidase 349586..350920 Streptococcus pneumoniae Hungary19A-6 6028142 YP_001693809.1 CDS SPH_0398 NC_010380.1 350976 351887 R identified by match to protein family HMM PF03613; match to protein family HMM TIGR00828; PTS system mannose/fructose/sorbose family EIID subunit complement(350976..351887) Streptococcus pneumoniae Hungary19A-6 6029553 YP_001693810.1 CDS SPH_0399 NC_010380.1 351911 352714 R identified by match to protein family HMM PF03609; PTS system sorbose-specific EIIC component complement(351911..352714) Streptococcus pneumoniae Hungary19A-6 6029367 YP_001693811.1 CDS SPH_0400 NC_010380.1 352742 353731 R identified by match to protein family HMM PF03610; match to protein family HMM PF03830; mannose-specific phosphotransferase system component IIAB complement(352742..353731) Streptococcus pneumoniae Hungary19A-6 6028363 YP_001693812.1 CDS SPH_0401 NC_010380.1 353962 354981 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(353962..354981) Streptococcus pneumoniae Hungary19A-6 6029913 YP_001693813.1 CDS SPH_0402 NC_010380.1 355321 356133 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(355321..356133) Streptococcus pneumoniae Hungary19A-6 6028021 YP_001693814.1 CDS SPH_0403 NC_010380.1 356269 357741 D identified by match to protein family HMM PF00860; xanthine/uracil permease 356269..357741 Streptococcus pneumoniae Hungary19A-6 6027895 YP_001693815.1 CDS SPH_0404 NC_010380.1 357794 358501 D identified by match to protein family HMM PF02517; caax amino protease 357794..358501 Streptococcus pneumoniae Hungary19A-6 6028877 YP_001693816.1 CDS SPH_0405 NC_010380.1 358618 358731 D identified by glimmer; hypothetical protein 358618..358731 Streptococcus pneumoniae Hungary19A-6 6027888 YP_001693817.1 CDS folP NC_010380.1 358746 359726 D identified by match to protein family HMM PF00809; match to protein family HMM TIGR01496; dihydropteroate synthase 358746..359726 Streptococcus pneumoniae Hungary19A-6 6028345 YP_001693818.1 CDS SPH_0407 NC_010380.1 359728 361050 D identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; dihydrofolate synthetase 359728..361050 Streptococcus pneumoniae Hungary19A-6 6029186 YP_001693819.1 CDS folE NC_010380.1 361031 361585 D involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 361031..361585 Streptococcus pneumoniae Hungary19A-6 6029618 YP_001693820.1 CDS SPH_0409 NC_010380.1 361628 362440 D identified by match to protein family HMM PF01288; match to protein family HMM PF02152; match to protein family HMM TIGR00525; match to protein family HMM TIGR00526; match to protein family HMM TIGR01498; bifunctional folate synthesis protein 361628..362440 Streptococcus pneumoniae Hungary19A-6 6029874 YP_001693821.1 CDS SPH_0410 NC_010380.1 362485 362802 R hypothetical protein complement(362485..362802) Streptococcus pneumoniae Hungary19A-6 6029272 YP_001693822.1 CDS rplM NC_010380.1 363158 363604 D in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 363158..363604 Streptococcus pneumoniae Hungary19A-6 6028785 YP_001693823.1 CDS rpsI NC_010380.1 363624 364016 D forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 363624..364016 Streptococcus pneumoniae Hungary19A-6 6029583 YP_001693824.1 CDS SPH_0413 NC_010380.1 364279 365157 R identified by match to protein family HMM PF00589; phage integrase integrase/recombinase complement(364279..365157) Streptococcus pneumoniae Hungary19A-6 6028331 YP_001693825.1 CDS SPH_0414 NC_010380.1 365399 366088 R identified by glimmer; hypothetical protein complement(365399..366088) Streptococcus pneumoniae Hungary19A-6 6029959 YP_001693826.1 CDS SPH_0415 NC_010380.1 366175 366585 R hypothetical protein complement(366175..366585) Streptococcus pneumoniae Hungary19A-6 6027952 YP_001693827.1 CDS SPH_0416 NC_010380.1 366642 367532 R identified by glimmer; hypothetical protein complement(366642..367532) Streptococcus pneumoniae Hungary19A-6 6029812 YP_001693828.1 CDS SPH_0417 NC_010380.1 367735 368475 D hypothetical protein 367735..368475 Streptococcus pneumoniae Hungary19A-6 6028997 YP_001693829.1 CDS SPH_0418 NC_010380.1 368591 368947 D identified by glimmer; hypothetical protein 368591..368947 Streptococcus pneumoniae Hungary19A-6 6028298 YP_001693830.1 CDS SPH_0419 NC_010380.1 369502 369723 R phage integrase integrase/recombinase complement(369502..369723) Streptococcus pneumoniae Hungary19A-6 6029395 YP_001693831.1 CDS SPH_0420 NC_010380.1 369828 369947 R hypothetical protein complement(369828..369947) Streptococcus pneumoniae Hungary19A-6 6029662 YP_001693832.1 CDS SPH_0421 NC_010380.1 370279 371487 R ATPase complement(370279..371487) Streptococcus pneumoniae Hungary19A-6 6027713 YP_001693833.1 CDS SPH_0422 NC_010380.1 371575 371700 D identified by glimmer; hypothetical protein 371575..371700 Streptococcus pneumoniae Hungary19A-6 6028543 YP_001693834.1 CDS SPH_0423 NC_010380.1 371892 372068 D hypothetical protein 371892..372068 Streptococcus pneumoniae Hungary19A-6 6029616 YP_001693835.1 CDS SPH_0424 NC_010380.1 372469 374682 D identified by match to protein family HMM PF01055; glycosy hydrolase 372469..374682 Streptococcus pneumoniae Hungary19A-6 6029651 YP_001693836.1 CDS SPH_0425 NC_010380.1 374904 375380 R hydrogen peroxide resistanceprotein 1; oxidant receptor peroxidase 1; glutathione peroxidase 3; phospholipid hydroperoxide glutathione peroxidase 3; phgpx3; identified by match to protein family HMM PF00255; peroxiredoxin Hyr1 complement(374904..375380) Streptococcus pneumoniae Hungary19A-6 6028588 YP_001693837.1 CDS SPH_0426 NC_010380.1 375603 378806 D identified by match to protein family HMM PF00746; match to protein family HMM PF02018; match to protein family HMM PF02278; match to protein family HMM PF02884; match to protein family HMM PF08124; match to protein family HMM TIGR01167; hyaluronate lyase 375603..378806 Streptococcus pneumoniae Hungary19A-6 6029632 YP_001693838.1 CDS SPH_0428 NC_010380.1 379950 380579 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(379950..380579) Streptococcus pneumoniae Hungary19A-6 6027772 YP_001693839.1 CDS SPH_0429 NC_010380.1 380589 381590 R identified by match to protein family HMM PF00294; 2-keto-3-deoxygluconate kinase complement(380589..381590) Streptococcus pneumoniae Hungary19A-6 6029777 YP_001693840.1 CDS SPH_0430 NC_010380.1 381621 382262 R identified by match to protein family HMM PF02502; hypothetical protein complement(381621..382262) Streptococcus pneumoniae Hungary19A-6 6028439 YP_001693841.1 CDS SPH_0431 NC_010380.1 382281 383096 R Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase complement(382281..383096) Streptococcus pneumoniae Hungary19A-6 6028236 YP_001693842.1 CDS SPH_0432 NC_010380.1 383368 383802 D identified by match to protein family HMM PF03610; phosphotransferase system sugar-specific EII component 383368..383802 Streptococcus pneumoniae Hungary19A-6 6028694 YP_001693843.1 CDS SPH_0433 NC_010380.1 383814 385004 D UGL; Glycuronidase; Unsaturated uronic acid hydrolase; Glycosaminoglycan hydrolase; identified by match to protein family HMM PF07470; unsaturated glucuronyl hydrolase 383814..385004 Streptococcus pneumoniae Hungary19A-6 6027693 YP_001693844.1 CDS SPH_0434 NC_010380.1 385015 385506 D pts system n-acetylgalactosamine-specific eiib component 2; eiib-aga'; identified by match to protein family HMM PF03830; N-acetylgalactosamine-specific phosphotransferase enzyme IIB component2 385015..385506 Streptococcus pneumoniae Hungary19A-6 6028764 YP_001693845.1 CDS SPH_0435 NC_010380.1 385521 386300 D identified by match to protein family HMM PF03609; phosphotransferase system sugar-specific EII component 385521..386300 Streptococcus pneumoniae Hungary19A-6 6028802 YP_001693846.1 CDS SPH_0436 NC_010380.1 386287 387105 D identified by match to protein family HMM PF03613; phosphotransferase system sugar-specific EII component 386287..387105 Streptococcus pneumoniae Hungary19A-6 6028815 YP_001693847.1 CDS yajC1 NC_010380.1 387105 387398 D identified by match to protein family HMM PF02699; match to protein family HMM TIGR00739; preprotein translocase, YajC subunit 387105..387398 Streptococcus pneumoniae Hungary19A-6 6029449 YP_001693848.1 CDS SPH_0438 NC_010380.1 387420 389321 D identified by match to protein family HMM PF07940; oligohyaluronate lyase 387420..389321 Streptococcus pneumoniae Hungary19A-6 6030071 YP_001693849.1 CDS SPH_0439 NC_010380.1 389381 390382 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sugar binding transcriptional regulator RegR 389381..390382 Streptococcus pneumoniae Hungary19A-6 6029975 YP_001693850.1 CDS SPH_0440 NC_010380.1 390492 390827 R identified by glimmer; hypothetical protein complement(390492..390827) Streptococcus pneumoniae Hungary19A-6 6028263 YP_001693851.1 CDS SPH_0441 NC_010380.1 390838 391080 R identified by glimmer; hypothetical protein complement(390838..391080) Streptococcus pneumoniae Hungary19A-6 6029034 YP_001693852.1 CDS SPH_0442 NC_010380.1 391091 391633 R hypothetical protein complement(391091..391633) Streptococcus pneumoniae Hungary19A-6 6029824 YP_001693853.1 CDS SPH_0443 NC_010380.1 391649 391843 R identified by match to protein family HMM PF01381; hypothetical protein complement(391649..391843) Streptococcus pneumoniae Hungary19A-6 6028072 YP_001693854.1 CDS mraW NC_010380.1 392011 392961 D identified by match to protein family HMM PF01795; match to protein family HMM TIGR00006; S-adenosyl-methyltransferase MraW 392011..392961 Streptococcus pneumoniae Hungary19A-6 6028937 YP_001693855.1 CDS ftsL NC_010380.1 392973 393290 D identified by match to protein family HMM TIGR02209; cell division protein FtsL 392973..393290 Streptococcus pneumoniae Hungary19A-6 6028563 YP_001693856.1 CDS SPH_0446 NC_010380.1 393294 395546 D identified by match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM PF03793; penicillin-binding protein 2X 393294..395546 Streptococcus pneumoniae Hungary19A-6 6029044 YP_001693857.1 CDS mraY NC_010380.1 395548 396528 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 395548..396528 Streptococcus pneumoniae Hungary19A-6 6029160 YP_001693858.1 CDS SPH_0448 NC_010380.1 396665 396817 D identified by glimmer; hypothetical protein 396665..396817 Streptococcus pneumoniae Hungary19A-6 6030087 YP_001693859.1 CDS SPH_0449 NC_010380.1 397277 399382 D identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; ATP-dependent Clp protease ATP-binding subunit ClpL 397277..399382 Streptococcus pneumoniae Hungary19A-6 6027776 YP_001693860.1 CDS luxS NC_010380.1 399678 400160 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(399678..400160) Streptococcus pneumoniae Hungary19A-6 6029035 YP_001693861.1 CDS SPH_0451 NC_010380.1 400255 401739 R identified by match to protein family HMM PF08903; hypothetical protein complement(400255..401739) Streptococcus pneumoniae Hungary19A-6 6029007 YP_001693862.1 CDS SPH_0452 NC_010380.1 401892 403499 D identified by match to protein family HMM PF00128; trehalose-6-phosphate hydrolase (Alpha,alpha-phosphotrehalase) 401892..403499 Streptococcus pneumoniae Hungary19A-6 6028409 YP_001693863.1 CDS SPH_0453 NC_010380.1 403659 403832 D lipoprotein 403659..403832 Streptococcus pneumoniae Hungary19A-6 6028344 YP_001693864.1 CDS SPH_0454 NC_010380.1 404341 404670 R identified by match to protein family HMM PF01710; transposase complement(404341..404670) Streptococcus pneumoniae Hungary19A-6 6029938 YP_001693865.1 CDS SPH_0455 NC_010380.1 404901 406346 D identified by match to protein family HMM PF02916; match to protein family HMM PF03816; match to protein family HMM TIGR00350; integral membrane regulatory protein Wzg 404901..406346 Streptococcus pneumoniae Hungary19A-6 6028700 YP_001693866.1 CDS SPH_0456 NC_010380.1 406348 407079 D identified by match to protein family HMM PF02811; tyrosine-protein phosphatase CpsB 406348..407079 Streptococcus pneumoniae Hungary19A-6 6030047 YP_001693867.1 CDS SPH_0457 NC_010380.1 407088 407780 D identified by match to protein family HMM PF02706; match to protein family HMM TIGR01006; Cps19aC 407088..407780 Streptococcus pneumoniae Hungary19A-6 6027848 YP_001693868.1 CDS SPH_0458 NC_010380.1 407790 408479 D identified by match to protein family HMM TIGR01007; tyrosine-protein kinase CpsD 407790..408479 Streptococcus pneumoniae Hungary19A-6 6028025 YP_001693869.1 CDS SPH_0459 NC_010380.1 408494 409855 D identified by match to protein family HMM PF02397; match to protein family HMM TIGR03025; galactosyl transferase CpsE 408494..409855 Streptococcus pneumoniae Hungary19A-6 6029102 YP_001693870.1 CDS SPH_0460 NC_010380.1 409861 410604 D identified by match to protein family HMM PF03808; match to protein family HMM TIGR00696; UDP-N-acetyl-D-mannosamine transferase 409861..410604 Streptococcus pneumoniae Hungary19A-6 6028517 YP_001693871.1 CDS SPH_0461 NC_010380.1 410601 411425 D identified by match to protein family HMM PF04991; Cps19aG 410601..411425 Streptococcus pneumoniae Hungary19A-6 6029705 YP_001693872.1 CDS SPH_0462 NC_010380.1 411427 412305 D identified by match to protein family HMM PF00535; glycosyl transferase 411427..412305 Streptococcus pneumoniae Hungary19A-6 6029976 YP_001693873.1 CDS SPH_0463 NC_010380.1 412306 413640 D polysaccharide polymerase Cps19aI 412306..413640 Streptococcus pneumoniae Hungary19A-6 6027761 YP_001693874.1 CDS SPH_0464 NC_010380.1 413668 415092 D identified by match to protein family HMM PF01943; flippase Wzx 413668..415092 Streptococcus pneumoniae Hungary19A-6 6028149 YP_001693875.1 CDS SPH_0465 NC_010380.1 415157 416245 D identified by match to protein family HMM PF02350; match to protein family HMM TIGR00236; UDP-N-acetylglucosamine 2-epimerase 415157..416245 Streptococcus pneumoniae Hungary19A-6 6027988 YP_001693876.1 CDS rfbA NC_010380.1 416408 417277 D identified by match to protein family HMM PF00483; match to protein family HMM TIGR01207; glucose-1-phosphate thymidylyltransferase 416408..417277 Streptococcus pneumoniae Hungary19A-6 6029745 YP_001693877.1 CDS SPH_0467 NC_010380.1 417278 417871 D identified by match to protein family HMM PF00908; dTDP-4-dehydrorhamnose 3,5-epimerase 417278..417871 Streptococcus pneumoniae Hungary19A-6 6027788 YP_001693878.1 CDS rfbB NC_010380.1 417883 418932 D identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181; dTDP-glucose 4,6-dehydratase 417883..418932 Streptococcus pneumoniae Hungary19A-6 6028242 YP_001693879.1 CDS rfbD NC_010380.1 418998 419849 D identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01214; dTDP-4-dehydrorhamnose reductase 418998..419849 Streptococcus pneumoniae Hungary19A-6 6028197 YP_001693880.1 CDS SPH_0474 NC_010380.1 422552 424534 D identified by match to protein family HMM PF00496; oligopeptide binding protein 422552..424534 Streptococcus pneumoniae Hungary19A-6 6028273 YP_001693881.1 CDS SPH_0475 NC_010380.1 424907 430138 D identified by match to protein family HMM PF00754; match to protein family HMM TIGR01167; endo-alpha-N-acetylgalactosaminidase 424907..430138 Streptococcus pneumoniae Hungary19A-6 6029564 YP_001693882.1 CDS SPH_0476 NC_010380.1 430305 432464 R identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 1A complement(430305..432464) Streptococcus pneumoniae Hungary19A-6 6029274 YP_001693883.1 CDS recU NC_010380.1 432461 433057 R functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease complement(432461..433057) Streptococcus pneumoniae Hungary19A-6 6027878 YP_001693884.1 CDS SPH_0478 NC_010380.1 433124 433651 D identified by match to protein family HMM PF06908; hypothetical protein 433124..433651 Streptococcus pneumoniae Hungary19A-6 6028221 YP_001693885.1 CDS SPH_0479 NC_010380.1 433721 434062 D identified by match to protein family HMM PF05103; cell division initiation protein 433721..434062 Streptococcus pneumoniae Hungary19A-6 6028597 YP_001693886.1 CDS SPH_0480 NC_010380.1 434548 435705 D identified by match to protein family HMM PF01170; methyltransferase 434548..435705 Streptococcus pneumoniae Hungary19A-6 6028756 YP_001693887.1 CDS SPH_0481 NC_010380.1 435718 437130 D hypothetical protein 435718..437130 Streptococcus pneumoniae Hungary19A-6 6028735 YP_001693888.1 CDS gnd NC_010380.1 437206 438630 D catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 437206..438630 Streptococcus pneumoniae Hungary19A-6 6029131 YP_001693889.1 CDS SPH_0483 NC_010380.1 438642 439331 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator 438642..439331 Streptococcus pneumoniae Hungary19A-6 6028453 YP_001693890.1 CDS SPH_0484 NC_010380.1 439430 440449 D identified by match to protein family HMM PF01473; choline-binding protein F 439430..440449 Streptococcus pneumoniae Hungary19A-6 6027712 YP_001693891.1 CDS SPH_0485 NC_010380.1 440567 441799 R identified by match to protein family HMM PF07690; transporter major facilitator family protein complement(440567..441799) Streptococcus pneumoniae Hungary19A-6 6028054 YP_001693892.1 CDS SPH_0487 NC_010380.1 443536 443658 D identified by match to protein family HMM PF01473; choline-binding protein F 443536..443658 Streptococcus pneumoniae Hungary19A-6 6028730 YP_001693893.1 CDS mvk NC_010380.1 443780 444658 D identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR00549; mevalonate kinase 443780..444658 Streptococcus pneumoniae Hungary19A-6 6028947 YP_001693894.1 CDS mvaD NC_010380.1 444640 445593 D identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR01240; diphosphomevalonate decarboxylase 444640..445593 Streptococcus pneumoniae Hungary19A-6 6028612 YP_001693895.1 CDS SPH_0490 NC_010380.1 445580 446587 D identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR01220; phosphomevalonate kinase 445580..446587 Streptococcus pneumoniae Hungary19A-6 6029701 YP_001693896.1 CDS fni NC_010380.1 446571 447581 D catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 446571..447581 Streptococcus pneumoniae Hungary19A-6 6027808 YP_001693897.1 CDS SPH_0492 NC_010380.1 447658 448356 D hypothetical protein 447658..448356 Streptococcus pneumoniae Hungary19A-6 6029542 YP_001693898.1 CDS SPH_0493 NC_010380.1 448353 449348 D identified by match to protein family HMM PF02518; match to protein family HMM PF07730; histidine kinase 448353..449348 Streptococcus pneumoniae Hungary19A-6 6028075 YP_001693899.1 CDS SPH_0494 NC_010380.1 449362 449994 D identified by match to protein family HMM PF00072; match to protein family HMM PF00196; match to protein family HMM PF08281; response regulator 449362..449994 Streptococcus pneumoniae Hungary19A-6 6028118 YP_001693900.1 CDS SPH_0498 NC_010380.1 450914 451153 D hypothetical protein 450914..451153 Streptococcus pneumoniae Hungary19A-6 6028314 YP_001693901.1 CDS SPH_0501 NC_010380.1 452082 453104 D identified by match to protein family HMM PF01473; choline binding protein F 452082..453104 Streptococcus pneumoniae Hungary19A-6 6028513 YP_001693902.1 CDS SPH_0502 NC_010380.1 453234 454067 R identified by match to protein family HMM PF00665; integrase core subunit complement(453234..454067) Streptococcus pneumoniae Hungary19A-6 6028048 YP_001693903.1 CDS SPH_0504 NC_010380.1 454714 456483 D identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00851; pts system mannitol-specific eiicb component (eiicb-mtl) (eii-mtl) 454714..456483 Streptococcus pneumoniae Hungary19A-6 6029829 YP_001693904.1 CDS SPH_0505 NC_010380.1 456507 458462 D identified by match to protein family HMM PF08279; transcriptional regulator MtlR 456507..458462 Streptococcus pneumoniae Hungary19A-6 6029148 YP_001693905.1 CDS SPH_0506 NC_010380.1 458464 458901 D pts system mannitol-specific eiia component; eiia-mtl; eiii-mtl; identified by match to protein family HMM PF00359; mannitol-specific phosphotransferase enzyme IIA component 458464..458901 Streptococcus pneumoniae Hungary19A-6 6028446 YP_001693906.1 CDS SPH_0507 NC_010380.1 458963 460099 D identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol-1-phosphate 5-dehydrogenase 458963..460099 Streptococcus pneumoniae Hungary19A-6 6028640 YP_001693907.1 CDS SPH_0508 NC_010380.1 460443 460556 D hypothetical protein 460443..460556 Streptococcus pneumoniae Hungary19A-6 6028542 YP_001693908.1 CDS tig NC_010380.1 460860 462143 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 460860..462143 Streptococcus pneumoniae Hungary19A-6 6028038 YP_001693909.1 CDS SPH_0510 NC_010380.1 462191 464557 R identified by match to protein family HMM TIGR01448; RecD/TraA family helicase complement(462191..464557) Streptococcus pneumoniae Hungary19A-6 6028954 YP_001693910.1 CDS lepB NC_010380.1 464791 465405 R identified by match to protein family HMM PF00717; match to protein family HMM TIGR02227; signal peptidase I complement(464791..465405) Streptococcus pneumoniae Hungary19A-6 6027705 YP_001693911.1 CDS rnhC NC_010380.1 465417 466289 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII complement(465417..466289) Streptococcus pneumoniae Hungary19A-6 6029188 YP_001693912.1 CDS SPH_0513 NC_010380.1 466376 466678 D hypothetical protein 466376..466678 Streptococcus pneumoniae Hungary19A-6 6027806 YP_001693913.1 CDS cvpA NC_010380.1 466675 467223 D identified by match to protein family HMM PF02674; CvpA family protein 466675..467223 Streptococcus pneumoniae Hungary19A-6 6029768 YP_001693914.1 CDS SPH_0515 NC_010380.1 467327 469663 D identified by match to protein family HMM PF00488; match to protein family HMM PF01713; match to protein family HMM TIGR01069; MutS2 family protein 467327..469663 Streptococcus pneumoniae Hungary19A-6 6029231 YP_001693915.1 CDS SPH_0516 NC_010380.1 470010 471332 D identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835; D-alanine glycine permease 470010..471332 Streptococcus pneumoniae Hungary19A-6 6029621 YP_001693916.1 CDS SPH_0517 NC_010380.1 471550 472098 D identified by match to protein family HMM PF02627; match to protein family HMM TIGR00778; macrophage infectivity potentiator protein 471550..472098 Streptococcus pneumoniae Hungary19A-6 6028746 YP_001693917.1 CDS SPH_0518 NC_010380.1 472208 473107 D identified by match to protein family HMM PF03595; exfoliative toxin A 472208..473107 Streptococcus pneumoniae Hungary19A-6 6029241 YP_001693918.1 CDS serS NC_010380.1 473132 474406 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(473132..474406) Streptococcus pneumoniae Hungary19A-6 6029671 YP_001693919.1 CDS SPH_0520 NC_010380.1 474620 474991 R identified by match to protein family HMM PF06115; ManO complement(474620..474991) Streptococcus pneumoniae Hungary19A-6 6029992 YP_001693920.1 CDS SPH_0521 NC_010380.1 474994 476358 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase complement(474994..476358) Streptococcus pneumoniae Hungary19A-6 6029544 YP_001693921.1 CDS SPH_0522 NC_010380.1 476536 476691 R hypothetical protein complement(476536..476691) Streptococcus pneumoniae Hungary19A-6 6027873 YP_001693922.1 CDS SPH_0523 NC_010380.1 476683 477468 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 476683..477468 Streptococcus pneumoniae Hungary19A-6 6029772 YP_001693923.1 CDS SPH_0524 NC_010380.1 477562 477996 D identified by match to protein family HMM PF01047; match to protein family HMM PF03965; transcriptional regulator 477562..477996 Streptococcus pneumoniae Hungary19A-6 6028500 YP_001693924.1 CDS SPH_0525 NC_010380.1 477996 478970 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 477996..478970 Streptococcus pneumoniae Hungary19A-6 6028126 YP_001693925.1 CDS acpP NC_010380.1 479030 479254 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 479030..479254 Streptococcus pneumoniae Hungary19A-6 6029459 YP_001693926.1 CDS SPH_0527 NC_010380.1 479373 480347 D identified by match to protein family HMM PF03060; match to protein family HMM TIGR03151; enoyl-(acyl-carrier-protein) reductase II 479373..480347 Streptococcus pneumoniae Hungary19A-6 6028294 YP_001693927.1 CDS fabD NC_010380.1 480340 481260 D identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128; malonyl CoA-acyl carrier protein transacylase 480340..481260 Streptococcus pneumoniae Hungary19A-6 6030052 YP_001693928.1 CDS fabG NC_010380.1 481294 482025 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 481294..482025 Streptococcus pneumoniae Hungary19A-6 6027884 YP_001693929.1 CDS SPH_0531 NC_010380.1 482047 483282 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 482047..483282 Streptococcus pneumoniae Hungary19A-6 6028353 YP_001693930.1 CDS accB NC_010380.1 483285 483770 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 483285..483770 Streptococcus pneumoniae Hungary19A-6 6027835 YP_001693931.1 CDS fabZ NC_010380.1 483767 484189 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 483767..484189 Streptococcus pneumoniae Hungary19A-6 6028584 YP_001693932.1 CDS accC NC_010380.1 484201 485568 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 484201..485568 Streptococcus pneumoniae Hungary19A-6 6029623 YP_001693933.1 CDS accD NC_010380.1 485605 486471 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 485605..486471 Streptococcus pneumoniae Hungary19A-6 6027972 YP_001693934.1 CDS accA NC_010380.1 486468 487235 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha 486468..487235 Streptococcus pneumoniae Hungary19A-6 6028107 YP_001693935.1 CDS SPH_0537 NC_010380.1 487498 487683 D hypothetical protein 487498..487683 Streptococcus pneumoniae Hungary19A-6 6029903 YP_001693936.1 CDS SPH_0538 NC_010380.1 487740 488174 D hypothetical protein 487740..488174 Streptococcus pneumoniae Hungary19A-6 6028663 YP_001693937.1 CDS nusB NC_010380.1 488472 488894 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(488472..488894) Streptococcus pneumoniae Hungary19A-6 6029711 YP_001693938.1 CDS SPH_0540 NC_010380.1 488887 489276 R identified by match to protein family HMM PF03780; Gls24 family general stress protein complement(488887..489276) Streptococcus pneumoniae Hungary19A-6 6028907 YP_001693939.1 CDS efp NC_010380.1 489298 489858 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(489298..489858) Streptococcus pneumoniae Hungary19A-6 6029591 YP_001693940.1 CDS gatB NC_010380.1 489987 491429 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(489987..491429) Streptococcus pneumoniae Hungary19A-6 6028923 YP_001693941.1 CDS gatA NC_010380.1 491429 492895 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(491429..492895) Streptococcus pneumoniae Hungary19A-6 6027897 YP_001693942.1 CDS gatC NC_010380.1 492895 493197 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(492895..493197) Streptococcus pneumoniae Hungary19A-6 6029749 YP_001693943.1 CDS prfC NC_010380.1 493410 494954 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 493410..494954 Streptococcus pneumoniae Hungary19A-6 6029979 YP_001693944.1 CDS rpmB NC_010380.1 495821 496009 D required for 70S ribosome assembly; 50S ribosomal protein L28 495821..496009 Streptococcus pneumoniae Hungary19A-6 6028911 YP_001693945.1 CDS SPH_0549 NC_010380.1 496166 496531 D identified by match to protein family HMM PF03780; alkaline shock protein 496166..496531 Streptococcus pneumoniae Hungary19A-6 6028984 YP_001693946.1 CDS SPH_0550 NC_010380.1 496534 498201 D identified by match to protein family HMM PF02734; dihydroxyacetone kinase 496534..498201 Streptococcus pneumoniae Hungary19A-6 6028207 YP_001693947.1 CDS ilvB NC_010380.1 498402 500102 D catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit 498402..500102 Streptococcus pneumoniae Hungary19A-6 6028224 YP_001693948.1 CDS ilvH NC_010380.1 500095 500571 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 500095..500571 Streptococcus pneumoniae Hungary19A-6 6027912 YP_001693949.1 CDS ilvC NC_010380.1 500637 501659 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 500637..501659 Streptococcus pneumoniae Hungary19A-6 6029523 YP_001693950.1 CDS SPH_0554 NC_010380.1 501766 502002 D hypothetical protein 501766..502002 Streptococcus pneumoniae Hungary19A-6 6027899 YP_001693951.1 CDS SPH_0555 NC_010380.1 502240 502596 D hypothetical protein 502240..502596 Streptococcus pneumoniae Hungary19A-6 6027779 YP_001693952.1 CDS ilvA NC_010380.1 502646 503896 D catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 502646..503896 Streptococcus pneumoniae Hungary19A-6 6029014 YP_001693953.1 CDS SPH_0557 NC_010380.1 504038 504226 D hypothetical protein 504038..504226 Streptococcus pneumoniae Hungary19A-6 6028476 YP_001693954.1 CDS SPH_0558 NC_010380.1 504767 504982 D hypothetical protein 504767..504982 Streptococcus pneumoniae Hungary19A-6 6029894 YP_001693955.1 CDS SPH_0559 NC_010380.1 505091 505831 R identified by match to protein family HMM PF00005; L-cystine import ATP-binding protein TcyN complement(505091..505831) Streptococcus pneumoniae Hungary19A-6 6028939 YP_001693956.1 CDS SPH_0560 NC_010380.1 505831 507396 R identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter amino acid-binding protein/permease complement(505831..507396) Streptococcus pneumoniae Hungary19A-6 6028057 YP_001693957.1 CDS SPH_0562 NC_010380.1 507534 509423 D hypothetical protein 507534..509423 Streptococcus pneumoniae Hungary19A-6 6029630 YP_001693958.1 CDS SPH_0561 NC_010380.1 509420 509590 R hypothetical protein complement(509420..509590) Streptococcus pneumoniae Hungary19A-6 6030037 YP_001693959.1 CDS SPH_0565 NC_010380.1 511007 511852 D Undecaprenyl pyrophosphatephosphatase; Bacitracin resistance protein; BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 511007..511852 Streptococcus pneumoniae Hungary19A-6 6029961 YP_001693960.1 CDS SPH_0566 NC_010380.1 511845 511973 D hypothetical protein 511845..511973 Streptococcus pneumoniae Hungary19A-6 6029293 YP_001693961.1 CDS SPH_0567 NC_010380.1 511999 513060 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(511999..513060) Streptococcus pneumoniae Hungary19A-6 6029741 YP_001693962.1 CDS SPH_0568 NC_010380.1 513095 513226 R identified by glimmer; hypothetical protein complement(513095..513226) Streptococcus pneumoniae Hungary19A-6 6028137 YP_001693963.1 CDS pflB NC_010380.1 513453 515777 D identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255; formate acetyltransferase 513453..515777 Streptococcus pneumoniae Hungary19A-6 6028211 YP_001693964.1 CDS SPH_0570 NC_010380.1 515835 517097 R identified by match to protein family HMM PF01610; transposase complement(515835..517097) Streptococcus pneumoniae Hungary19A-6 6028635 YP_001693965.1 CDS SPH_0571 NC_010380.1 517362 518891 R identified by match to protein family HMM PF05043; match to protein family HMM PF08270; match to protein family HMM PF08280; transcriptional regulator complement(517362..518891) Streptococcus pneumoniae Hungary19A-6 6029501 YP_001693966.1 CDS SPH_0572 NC_010380.1 519407 522058 D identified by match to protein family HMM PF00092; match to protein family HMM PF05738; match to protein family HMM TIGR01167; cell wall surface anchor family protein 519407..522058 Streptococcus pneumoniae Hungary19A-6 6029047 YP_001693967.1 CDS SPH_0574 NC_010380.1 522291 524225 D identified by match to protein family HMM PF00746; match to protein family HMM PF05738; match to protein family HMM TIGR01167; cell wall surface anchor family protein 522291..524225 Streptococcus pneumoniae Hungary19A-6 6028173 YP_001693968.1 CDS SPH_0573 NC_010380.1 524191 524577 R identified by glimmer; hypothetical protein complement(524191..524577) Streptococcus pneumoniae Hungary19A-6 6028320 YP_001693969.1 CDS SPH_0575 NC_010380.1 524542 525453 D identified by match to protein family HMM PF05738; match to protein family HMM TIGR01167; cell wall surface anchor family protein 524542..525453 Streptococcus pneumoniae Hungary19A-6 6028881 YP_001693970.1 CDS SPH_0576 NC_010380.1 525791 526693 D identified by match to protein family HMM PF04203; match to protein family HMM TIGR01076; sortase 525791..526693 Streptococcus pneumoniae Hungary19A-6 6027775 YP_001693971.1 CDS SPH_0577 NC_010380.1 526680 527573 D identified by match to protein family HMM PF04203; match to protein family HMM TIGR01076; sortase 526680..527573 Streptococcus pneumoniae Hungary19A-6 6029219 YP_001693972.1 CDS SPH_0578 NC_010380.1 527560 528411 D identified by match to protein family HMM PF04203; match to protein family HMM TIGR01076; sortase 527560..528411 Streptococcus pneumoniae Hungary19A-6 6028229 YP_001693973.1 CDS SPH_0582 NC_010380.1 529924 530073 R hypothetical protein complement(529924..530073) Streptococcus pneumoniae Hungary19A-6 6029308 YP_001693974.1 CDS SPH_0583 NC_010380.1 530066 530350 R hypothetical protein complement(530066..530350) Streptococcus pneumoniae Hungary19A-6 6028136 YP_001693975.1 CDS SPH_0584 NC_010380.1 530742 530915 D identified by glimmer; hypothetical protein 530742..530915 Streptococcus pneumoniae Hungary19A-6 6029063 YP_001693976.1 CDS SPH_0585 NC_010380.1 531784 533007 R identified by match to protein family HMM PF00480; ROK family protein complement(531784..533007) Streptococcus pneumoniae Hungary19A-6 6029674 YP_001693977.1 CDS SPH_0586 NC_010380.1 533175 534497 D pts system lichenan-specific eiiccomponent; eiic-lic; identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; lichenan permease IIC component 533175..534497 Streptococcus pneumoniae Hungary19A-6 6030053 YP_001693978.1 CDS SPH_0587 NC_010380.1 534499 536385 D hypothetical protein 534499..536385 Streptococcus pneumoniae Hungary19A-6 6029615 YP_001693979.1 CDS SPH_0588 NC_010380.1 536553 536897 D pts system lactose-specific eiia component; eiia-lac; eiii-lac; identified by match to protein family HMM PF02255; lactose-specific phosphotransferase enzyme IIA component 536553..536897 Streptococcus pneumoniae Hungary19A-6 6028156 YP_001693980.1 CDS lacG1 NC_010380.1 536907 538319 D catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 536907..538319 Streptococcus pneumoniae Hungary19A-6 6028501 YP_001693981.1 CDS SPH_0590 NC_010380.1 538389 540068 D identified by match to protein family HMM PF02302; match to protein family HMM PF02378; pts system lactose-specific eiicb component (eiicb-lac) (eii-lac) 538389..540068 Streptococcus pneumoniae Hungary19A-6 6027842 YP_001693982.1 CDS SPH_0591 NC_010380.1 540194 541633 R identified by match to protein family HMM PF02386; Trk transporter membrane-spanning protein - K+ transport complement(540194..541633) Streptococcus pneumoniae Hungary19A-6 6029759 YP_001693983.1 CDS trkA NC_010380.1 541637 542986 R involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component complement(541637..542986) Streptococcus pneumoniae Hungary19A-6 6029925 YP_001693984.1 CDS SPH_0593 NC_010380.1 543175 544023 D identified by match to protein family HMM PF01887; hypothetical protein 543175..544023 Streptococcus pneumoniae Hungary19A-6 6029927 YP_001693985.1 CDS SPH_0594 NC_010380.1 544038 544586 D identified by match to protein family HMM PF07155; hypothetical protein 544038..544586 Streptococcus pneumoniae Hungary19A-6 6028219 YP_001693986.1 CDS SPH_0595 NC_010380.1 544593 544895 D chlorohydrolase 544593..544895 Streptococcus pneumoniae Hungary19A-6 6028644 YP_001693987.1 CDS SPH_0596 NC_010380.1 544997 546679 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein // 544997..546679 Streptococcus pneumoniae Hungary19A-6 6029714 YP_001693988.1 CDS SPH_0597 NC_010380.1 546664 547494 D identified by match to protein family HMM PF02361; cobalt transport family protein 546664..547494 Streptococcus pneumoniae Hungary19A-6 6027708 YP_001693989.1 CDS SPH_0598 NC_010380.1 547687 548190 D identified by match to protein family HMM PF00588; RNA methyltransferase 547687..548190 Streptococcus pneumoniae Hungary19A-6 6028587 YP_001693990.1 CDS SPH_0599 NC_010380.1 548643 549206 D hypothetical protein 548643..549206 Streptococcus pneumoniae Hungary19A-6 6028086 YP_001693991.1 CDS SPH_0600 NC_010380.1 549220 549846 D identified by match to protein family HMM PF01569; PAP2 family protein 549220..549846 Streptococcus pneumoniae Hungary19A-6 6029868 YP_001693992.1 CDS SPH_0601 NC_010380.1 549873 550262 D hypothetical protein 549873..550262 Streptococcus pneumoniae Hungary19A-6 6027977 YP_001693993.1 CDS SPH_0602 NC_010380.1 550267 550716 D hypothetical protein 550267..550716 Streptococcus pneumoniae Hungary19A-6 6028747 YP_001693994.1 CDS rpoE NC_010380.1 550844 551431 D participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 550844..551431 Streptococcus pneumoniae Hungary19A-6 6029269 YP_001693995.1 CDS SPH_0604 NC_010380.1 551521 551646 R identified by glimmer; hypothetical protein complement(551521..551646) Streptococcus pneumoniae Hungary19A-6 6030085 YP_001693996.1 CDS pyrG NC_010380.1 551821 553428 D CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 551821..553428 Streptococcus pneumoniae Hungary19A-6 6029334 YP_001693997.1 CDS SPH_0606 NC_010380.1 553969 555600 R identified by match to protein family HMM PF01895; match to protein family HMM PF02690; match to protein family HMM TIGR00704; sodium-dependent phosphate transporter complement(553969..555600) Streptococcus pneumoniae Hungary19A-6 6029484 YP_001693998.1 CDS SPH_0607 NC_010380.1 555893 560806 D identified by match to protein family HMM PF00746; match to protein family HMM PF00754; match to protein family HMM PF03644; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07523; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; endo-beta-N-acetylglucosaminidase D 555893..560806 Streptococcus pneumoniae Hungary19A-6 6029677 YP_001693999.1 CDS pgk NC_010380.1 560896 562092 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 560896..562092 Streptococcus pneumoniae Hungary19A-6 6029438 YP_001694000.1 CDS SPH_0609 NC_010380.1 562228 562755 D hypothetical protein 562228..562755 Streptococcus pneumoniae Hungary19A-6 6029306 YP_001694001.1 CDS SPH_0610 NC_010380.1 562832 563188 D identified by match to protein family HMM PF00376; HTH-type transcriptional regulator GlnR 562832..563188 Streptococcus pneumoniae Hungary19A-6 6029482 YP_001694002.1 CDS glnA NC_010380.1 563225 564571 D identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; glutamine synthetase, type I 563225..564571 Streptococcus pneumoniae Hungary19A-6 6029135 YP_001694003.1 CDS SPH_0612 NC_010380.1 564661 564780 R hypothetical protein complement(564661..564780) Streptococcus pneumoniae Hungary19A-6 6029057 YP_001694004.1 CDS SPH_0613 NC_010380.1 565038 565175 D hypothetical protein 565038..565175 Streptococcus pneumoniae Hungary19A-6 6028520 YP_001694005.1 CDS SPH_0614 NC_010380.1 565346 566626 D identified by match to protein family HMM PF01420; type I site-specific deoxyribonuclease chain S 565346..566626 Streptococcus pneumoniae Hungary19A-6 6029464 YP_001694006.1 CDS SPH_0615 NC_010380.1 566683 567480 D identified by match to protein family HMM PF00589; phage integrase integrase/recombinase 566683..567480 Streptococcus pneumoniae Hungary19A-6 6028324 YP_001694007.1 CDS SPH_0617 NC_010380.1 567491 568096 D identified by match to protein family HMM PF01420; type I restriction modification DNA specificity domain-containing protein 567491..568096 Streptococcus pneumoniae Hungary19A-6 6028960 YP_001694008.1 CDS SPH_0616 NC_010380.1 568044 569612 R identified by match to protein family HMM PF01420; type I restriction-modification system, S subunit complement(568044..569612) Streptococcus pneumoniae Hungary19A-6 6029247 YP_001694009.1 CDS SPH_0618 NC_010380.1 569612 571075 R identified by match to protein family HMM PF02384; match to protein family HMM PF05175; type I restriction enzyme EcoEI M protein (M.EcoEI) complement(569612..571075) Streptococcus pneumoniae Hungary19A-6 6029706 YP_001694010.1 CDS SPH_0619 NC_010380.1 571088 573421 R identified by match to protein family HMM PF00270; match to protein family HMM PF04313; match to protein family HMM PF04851; match to protein family HMM PF08463; type I restriction-modification system, R subunit complement(571088..573421) Streptococcus pneumoniae Hungary19A-6 6029242 YP_001694011.1 CDS SPH_0620 NC_010380.1 573799 573993 D hypothetical protein 573799..573993 Streptococcus pneumoniae Hungary19A-6 6029210 YP_001694012.1 CDS SPH_0621 NC_010380.1 574100 574537 D identified by glimmer; hypothetical protein 574100..574537 Streptococcus pneumoniae Hungary19A-6 6029094 YP_001694013.1 CDS hrcA NC_010380.1 574701 575735 D Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 574701..575735 Streptococcus pneumoniae Hungary19A-6 6030018 YP_001694014.1 CDS grpE NC_010380.1 575762 576286 D with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 575762..576286 Streptococcus pneumoniae Hungary19A-6 6029413 YP_001694015.1 CDS dnaK NC_010380.1 576766 578589 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 576766..578589 Streptococcus pneumoniae Hungary19A-6 6030040 YP_001694016.1 CDS dnaJ NC_010380.1 579349 580485 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 579349..580485 Streptococcus pneumoniae Hungary19A-6 6028103 YP_001694017.1 CDS SPH_0626 NC_010380.1 580807 581094 R hypothetical protein complement(580807..581094) Streptococcus pneumoniae Hungary19A-6 6027849 YP_001694018.1 CDS SPH_0627 NC_010380.1 581104 581514 R identified by match to protein family HMM PF01230; histidine triad domain-containing protein complement(581104..581514) Streptococcus pneumoniae Hungary19A-6 6029710 YP_001694019.1 CDS SPH_0628 NC_010380.1 581582 582313 D identified by match to protein family HMM PF00005; ABC-type transporter ATP-binding protein EcsA 581582..582313 Streptococcus pneumoniae Hungary19A-6 6028527 YP_001694020.1 CDS SPH_0629 NC_010380.1 582310 583359 D identified by match to protein family HMM PF05975; ABC transporter permease 582310..583359 Streptococcus pneumoniae Hungary19A-6 6028709 YP_001694021.1 CDS SPH_0630 NC_010380.1 583527 583856 R BlpT protein, fusion complement(583527..583856) Streptococcus pneumoniae Hungary19A-6 6028510 YP_001694022.1 CDS SPH_0631 NC_010380.1 584132 584470 D identified by match to protein family HMM PF04397; BlpS protein 584132..584470 Streptococcus pneumoniae Hungary19A-6 6028950 YP_001694023.1 CDS SPH_0632 NC_010380.1 584475 585212 D identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator 584475..585212 Streptococcus pneumoniae Hungary19A-6 6030002 YP_001694024.1 CDS SPH_0633 NC_010380.1 585226 586566 D identified by match to protein family HMM PF02518; histidine kinase 585226..586566 Streptococcus pneumoniae Hungary19A-6 6029510 YP_001694025.1 CDS SPH_0634 NC_010380.1 586608 586763 R identified by match to protein family HMM PF08128; match to protein family HMM TIGR01847; double glycine cleavage site bacteriolysin superfamily protein complement(586608..586763) Streptococcus pneumoniae Hungary19A-6 6029982 YP_001694026.1 CDS SPH_0635 NC_010380.1 586820 588181 R identified by match to protein family HMM TIGR01000; BlpC ABC transporter complement(586820..588181) Streptococcus pneumoniae Hungary19A-6 6028721 YP_001694027.1 CDS SPH_0636 NC_010380.1 588192 590345 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193; transport/processing ATP-binding protein ComA complement(588192..590345) Streptococcus pneumoniae Hungary19A-6 6029909 YP_001694028.1 CDS SPH_0637 NC_010380.1 590627 590824 D hypothetical protein 590627..590824 Streptococcus pneumoniae Hungary19A-6 6028948 YP_001694029.1 CDS SPH_0638 NC_010380.1 591291 591560 D identified by match to protein family HMM TIGR01847; bacteriocin BlpJ 591291..591560 Streptococcus pneumoniae Hungary19A-6 6029767 YP_001694030.1 CDS SPH_0639 NC_010380.1 591629 591859 D identified by match to protein family HMM TIGR01847; hypothetical protein 591629..591859 Streptococcus pneumoniae Hungary19A-6 6028232 YP_001694031.1 CDS SPH_0640 NC_010380.1 591862 591981 D identified by glimmer; hypothetical protein 591862..591981 Streptococcus pneumoniae Hungary19A-6 6029910 YP_001694032.1 CDS SPH_0641 NC_010380.1 592278 592442 D hypothetical protein 592278..592442 Streptococcus pneumoniae Hungary19A-6 6029946 YP_001694033.1 CDS SPH_0642 NC_010380.1 592439 592825 D identified by glimmer; hypothetical protein 592439..592825 Streptococcus pneumoniae Hungary19A-6 6028252 YP_001694034.1 CDS SPH_0643 NC_010380.1 592925 593308 D identified by glimmer; hypothetical protein 592925..593308 Streptococcus pneumoniae Hungary19A-6 6029127 YP_001694035.1 CDS SPH_0644 NC_010380.1 593360 594049 D identified by match to protein family HMM PF02517; immunity protein BlpY 593360..594049 Streptococcus pneumoniae Hungary19A-6 6028399 YP_001694036.1 CDS SPH_0646 NC_010380.1 594475 595086 D identified by match to protein family HMM PF02517; CAAX amino protease 594475..595086 Streptococcus pneumoniae Hungary19A-6 6027820 YP_001694037.1 CDS SPH_0647 NC_010380.1 595247 596041 D identified by match to protein family HMM PF01636; phosphotransferase 595247..596041 Streptococcus pneumoniae Hungary19A-6 6029601 YP_001694038.1 CDS trmB NC_010380.1 596038 596673 D tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 596038..596673 Streptococcus pneumoniae Hungary19A-6 6027858 YP_001694039.1 CDS SPH_0649 NC_010380.1 596799 597278 D in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 596799..597278 Streptococcus pneumoniae Hungary19A-6 6029344 YP_001694040.1 CDS nusA NC_010380.1 597322 598458 D modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 597322..598458 Streptococcus pneumoniae Hungary19A-6 6028514 YP_001694041.1 CDS SPH_0651 NC_010380.1 598480 598773 D identified by match to protein family HMM PF04296; hypothetical protein 598480..598773 Streptococcus pneumoniae Hungary19A-6 6028686 YP_001694042.1 CDS SPH_0652 NC_010380.1 598766 599065 D identified by match to protein family HMM PF01248; hypothetical protein 598766..599065 Streptococcus pneumoniae Hungary19A-6 6028537 YP_001694043.1 CDS infB NC_010380.1 599082 601874 D Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 599082..601874 Streptococcus pneumoniae Hungary19A-6 6029517 YP_001694044.1 CDS rbfA NC_010380.1 602125 602475 D associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 602125..602475 Streptococcus pneumoniae Hungary19A-6 6029892 YP_001694045.1 CDS SPH_0655 NC_010380.1 602754 603533 D hypothetical protein 602754..603533 Streptococcus pneumoniae Hungary19A-6 6029875 YP_001694046.1 CDS SPH_0656 NC_010380.1 603535 603717 D hypothetical protein 603535..603717 Streptococcus pneumoniae Hungary19A-6 6030006 YP_001694047.1 CDS SPH_0657 NC_010380.1 603714 603854 D hypothetical protein 603714..603854 Streptococcus pneumoniae Hungary19A-6 6028391 YP_001694048.1 CDS SPH_0658 NC_010380.1 603984 604136 R identified by glimmer; hypothetical protein complement(603984..604136) Streptococcus pneumoniae Hungary19A-6 6029329 YP_001694049.1 CDS SPH_0659 NC_010380.1 604167 604400 D identified by match to protein family HMM PF08984; hypothetical protein 604167..604400 Streptococcus pneumoniae Hungary19A-6 6029556 YP_001694050.1 CDS SPH_0660 NC_010380.1 604400 605734 D identified by match to protein family HMM PF01814; match to protein family HMM PF04282; match to protein family HMM TIGR00229; hemerythrin HHE cation binding domain-containing protein 604400..605734 Streptococcus pneumoniae Hungary19A-6 6028816 YP_001694051.1 CDS SPH_0661 NC_010380.1 605744 605998 D identified by match to protein family HMM PF08930; hypothetical protein 605744..605998 Streptococcus pneumoniae Hungary19A-6 6029423 YP_001694052.1 CDS SPH_0662 NC_010380.1 606094 606489 D hypothetical protein 606094..606489 Streptococcus pneumoniae Hungary19A-6 6028809 YP_001694053.1 CDS SPH_0663 NC_010380.1 606901 607350 D identified by glimmer; hypothetical protein 606901..607350 Streptococcus pneumoniae Hungary19A-6 6028876 YP_001694054.1 CDS SPH_0664 NC_010380.1 607337 607897 D identified by match to protein family HMM PF00583; acetyltransferase 607337..607897 Streptococcus pneumoniae Hungary19A-6 6028055 YP_001694055.1 CDS SPH_0665 NC_010380.1 607897 608475 D shikimate kinase 607897..608475 Streptococcus pneumoniae Hungary19A-6 6029496 YP_001694056.1 CDS valS NC_010380.1 608468 611119 D valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 608468..611119 Streptococcus pneumoniae Hungary19A-6 6027924 YP_001694057.1 CDS SPH_0667 NC_010380.1 611200 611364 D hypothetical protein 611200..611364 Streptococcus pneumoniae Hungary19A-6 6029771 YP_001694058.1 CDS SPH_0668 NC_010380.1 611415 612323 D identified by glimmer; hypothetical protein 611415..612323 Streptococcus pneumoniae Hungary19A-6 6029887 YP_001694059.1 CDS SPH_0669 NC_010380.1 612347 613018 D identified by glimmer; hypothetical protein 612347..613018 Streptococcus pneumoniae Hungary19A-6 6029046 YP_001694060.1 CDS SPH_0670 NC_010380.1 613398 614201 D identified by match to protein family HMM PF02661; Fic family protein 613398..614201 Streptococcus pneumoniae Hungary19A-6 6029398 YP_001694061.1 CDS SPH_0674 NC_010380.1 617557 618396 D identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator LicT 617557..618396 Streptococcus pneumoniae Hungary19A-6 6028200 YP_001694062.1 CDS SPH_0675 NC_010380.1 618414 620252 D identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00830; match to protein family HMM TIGR01995; phosphotransferase system sugar-specific EII component 618414..620252 Streptococcus pneumoniae Hungary19A-6 6029908 YP_001694063.1 CDS SPH_0677 NC_010380.1 620265 621680 D Gentiobiase; Cellobiase; Beta-D-glucoside glucohydrolase; Amygdalase; identified by match to protein family HMM PF00232; beta-glucosidase 620265..621680 Streptococcus pneumoniae Hungary19A-6 6029995 YP_001694064.1 CDS pheS NC_010380.1 622271 623317 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 622271..623317 Streptococcus pneumoniae Hungary19A-6 6028407 YP_001694065.1 CDS SPH_0679 NC_010380.1 623317 623826 D identified by match to protein family HMM PF00583; acetyltransferase 623317..623826 Streptococcus pneumoniae Hungary19A-6 6029931 YP_001694066.1 CDS pheT NC_010380.1 623903 626308 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 623903..626308 Streptococcus pneumoniae Hungary19A-6 6028539 YP_001694067.1 CDS SPH_0681 NC_010380.1 626376 627377 R identified by match to protein family HMM PF03372; hypothetical protein complement(626376..627377) Streptococcus pneumoniae Hungary19A-6 6029833 YP_001694068.1 CDS SPH_0682 NC_010380.1 627534 628028 D transposase 627534..628028 Streptococcus pneumoniae Hungary19A-6 6029181 YP_001694069.1 CDS SPH_0683 NC_010380.1 628107 628373 D identified by match to protein family HMM PF01381; helix-turn-helix domain-containing protein 628107..628373 Streptococcus pneumoniae Hungary19A-6 6028277 YP_001694070.1 CDS metE NC_010380.1 628633 630882 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 628633..630882 Streptococcus pneumoniae Hungary19A-6 6028023 YP_001694071.1 CDS metF NC_010380.1 630946 631812 D identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; 5,10-methylenetetrahydrofolate reductase 630946..631812 Streptococcus pneumoniae Hungary19A-6 6028293 YP_001694072.1 CDS pnp NC_010380.1 632497 634710 D identified by match to protein family HMM PF00013; match to protein family HMM PF00575; match to protein family HMM PF01138; match to protein family HMM PF03725; match to protein family HMM PF03726; polynucleotide phosphorylase 632497..634710 Streptococcus pneumoniae Hungary19A-6 6028043 YP_001694073.1 CDS cysE NC_010380.1 634726 635343 D identified by match to protein family HMM TIGR01172; serine O-acetyltransferase 634726..635343 Streptococcus pneumoniae Hungary19A-6 6028705 YP_001694074.1 CDS SPH_0688 NC_010380.1 635355 636239 D identified by match to protein family HMM PF00583; acetyltransferase 635355..636239 Streptococcus pneumoniae Hungary19A-6 6027919 YP_001694075.1 CDS cysS NC_010380.1 636292 637665 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 636292..637665 Streptococcus pneumoniae Hungary19A-6 6027714 YP_001694076.1 CDS SPH_0690 NC_010380.1 637658 638044 D identified by match to protein family HMM PF00636; ribonuclease III family protein 637658..638044 Streptococcus pneumoniae Hungary19A-6 6029655 YP_001694077.1 CDS SPH_0691 NC_010380.1 638048 638932 D leucine-rich protein 638048..638932 Streptococcus pneumoniae Hungary19A-6 6028147 YP_001694078.1 CDS SPH_0692 NC_010380.1 639069 639668 D identified by glimmer; hypothetical protein 639069..639668 Streptococcus pneumoniae Hungary19A-6 6029132 YP_001694079.1 CDS SPH_0694 NC_010380.1 640337 641614 D identified by match to protein family HMM PF02687; peptide ABC transporter permease 640337..641614 Streptococcus pneumoniae Hungary19A-6 6027997 YP_001694080.1 CDS SPH_0695 NC_010380.1 641627 642274 D identified by match to protein family HMM PF00005; peptide ABC transporter ATP-binding protein 641627..642274 Streptococcus pneumoniae Hungary19A-6 6029807 YP_001694081.1 CDS SPH_0696 NC_010380.1 642326 643705 D identified by match to protein family HMM PF02687; peptide ABC transporter permease 642326..643705 Streptococcus pneumoniae Hungary19A-6 6028438 YP_001694082.1 CDS SPH_0697 NC_010380.1 644017 644673 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; VncR, response regulator 644017..644673 Streptococcus pneumoniae Hungary19A-6 6029382 YP_001694083.1 CDS SPH_0698 NC_010380.1 644670 645998 D identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; VncS, histidine kinase 644670..645998 Streptococcus pneumoniae Hungary19A-6 6028423 YP_001694084.1 CDS fba NC_010380.1 646139 647020 D catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 646139..647020 Streptococcus pneumoniae Hungary19A-6 6028518 YP_001694085.1 CDS SPH_0700 NC_010380.1 647341 648531 R identified by match to protein family HMM PF00175; match to protein family HMM PF00970; match to protein family HMM PF01794; oxidoreductase, NAD-binding complement(647341..648531) Streptococcus pneumoniae Hungary19A-6 6029872 YP_001694086.1 CDS SPH_0701 NC_010380.1 648789 649448 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; ABC transporter membrane-spanning permease - glutamine transport complement(648789..649448) Streptococcus pneumoniae Hungary19A-6 6028026 YP_001694087.1 CDS SPH_0702 NC_010380.1 649458 650135 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; ABC transporter membrane-spanning permease - glutamine transport complement(649458..650135) Streptococcus pneumoniae Hungary19A-6 6027757 YP_001694088.1 CDS SPH_0703 NC_010380.1 650148 650942 R identified by match to protein family HMM PF00497; glutamine ABC transporter substrate-binding protein complement(650148..650942) Streptococcus pneumoniae Hungary19A-6 6027796 YP_001694089.1 CDS SPH_0704 NC_010380.1 650953 651711 R identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ complement(650953..651711) Streptococcus pneumoniae Hungary19A-6 6028966 YP_001694090.1 CDS recJ NC_010380.1 651988 654210 D identified by match to protein family HMM PF01368; match to protein family HMM PF02272; match to protein family HMM TIGR00644; single-stranded-DNA-specific exonuclease RecJ 651988..654210 Streptococcus pneumoniae Hungary19A-6 6029863 YP_001694091.1 CDS SPH_0706 NC_010380.1 654385 656046 D identified by match to protein family HMM PF00753; match to protein family HMM PF07521; metallo-beta-lactamase superfamily protein 654385..656046 Streptococcus pneumoniae Hungary19A-6 6028166 YP_001694092.1 CDS SPH_0707 NC_010380.1 656115 656894 D identified by match to protein family HMM PF00756; tributyrin esterase 656115..656894 Streptococcus pneumoniae Hungary19A-6 6028227 YP_001694093.1 CDS SPH_0708 NC_010380.1 657025 658245 D identified by match to protein family HMM PF02388; MurM 657025..658245 Streptococcus pneumoniae Hungary19A-6 6028665 YP_001694094.1 CDS SPH_0709 NC_010380.1 658250 659482 D identified by match to protein family HMM PF02388; MurN 658250..659482 Streptococcus pneumoniae Hungary19A-6 6028278 YP_001694095.1 CDS SPH_0710 NC_010380.1 659561 660262 D identified by match to protein family HMM PF00413; matrixin family protein 659561..660262 Streptococcus pneumoniae Hungary19A-6 6029157 YP_001694096.1 CDS uvrC NC_010380.1 660302 662149 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 660302..662149 Streptococcus pneumoniae Hungary19A-6 6028468 YP_001694097.1 CDS SPH_0712 NC_010380.1 662139 662972 D identified by match to protein family HMM PF00149; metallophosphoesterase 662139..662972 Streptococcus pneumoniae Hungary19A-6 6029825 YP_001694098.1 CDS SPH_0713 NC_010380.1 663154 663954 R identified by match to protein family HMM PF00497; glutamine ABC transporter substrate-binding protein complement(663154..663954) Streptococcus pneumoniae Hungary19A-6 6028010 YP_001694099.1 CDS SPH_0714 NC_010380.1 664125 664730 D identified by match to protein family HMM PF00881; oxidoreductase 664125..664730 Streptococcus pneumoniae Hungary19A-6 6029147 YP_001694100.1 CDS pepV NC_010380.1 664743 666143 D divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 664743..666143 Streptococcus pneumoniae Hungary19A-6 6029636 YP_001694101.1 CDS SPH_0716 NC_010380.1 666197 666775 D identified by match to protein family HMM PF03167; uracil DNA glycosylase 666197..666775 Streptococcus pneumoniae Hungary19A-6 6029906 YP_001694102.1 CDS SPH_0717 NC_010380.1 666935 667087 D identified by glimmer; hypothetical protein 666935..667087 Streptococcus pneumoniae Hungary19A-6 6029700 YP_001694103.1 CDS SPH_0718 NC_010380.1 667103 667222 D identified by glimmer; hypothetical protein 667103..667222 Streptococcus pneumoniae Hungary19A-6 6028965 YP_001694104.1 CDS brnQ NC_010380.1 667394 668719 D identified by match to protein family HMM PF05525; match to protein family HMM TIGR00796; branched-chain amino acid transport system II carrier protein 667394..668719 Streptococcus pneumoniae Hungary19A-6 6029406 YP_001694105.1 CDS SPH_0720 NC_010380.1 668817 669854 D identified by match to protein family HMM PF05343; peptidase, M42 668817..669854 Streptococcus pneumoniae Hungary19A-6 6029488 YP_001694106.1 CDS SPH_0721 NC_010380.1 669856 670317 D identified by match to protein family HMM PF01230; HIT family protein 669856..670317 Streptococcus pneumoniae Hungary19A-6 6027773 YP_001694107.1 CDS SPH_0722 NC_010380.1 670332 671048 D identified by match to protein family HMM PF02557; D-alanyl-D-alanine carboxypeptidase 670332..671048 Streptococcus pneumoniae Hungary19A-6 6029669 YP_001694108.1 CDS rplK NC_010380.1 671171 671596 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 671171..671596 Streptococcus pneumoniae Hungary19A-6 6029957 YP_001694109.1 CDS rplA NC_010380.1 671804 672493 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 671804..672493 Streptococcus pneumoniae Hungary19A-6 6028695 YP_001694110.1 CDS SPH_0725 NC_010380.1 673034 673225 R chlorohydrolase complement(673034..673225) Streptococcus pneumoniae Hungary19A-6 6028247 YP_001694111.1 CDS SPH_0726 NC_010380.1 673239 673601 D hypothetical protein 673239..673601 Streptococcus pneumoniae Hungary19A-6 6029867 YP_001694112.1 CDS SPH_0727 NC_010380.1 674646 675638 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein - role in polysaccharide efflux 674646..675638 Streptococcus pneumoniae Hungary19A-6 6029435 YP_001694113.1 CDS SPH_0728 NC_010380.1 675640 676458 D identified by match to protein family HMM PF06182; membrane protein 675640..676458 Streptococcus pneumoniae Hungary19A-6 6028028 YP_001694114.1 CDS SPH_0729 NC_010380.1 676460 677245 D identified by match to protein family HMM PF06182; ABC transporter permease 676460..677245 Streptococcus pneumoniae Hungary19A-6 6029888 YP_001694115.1 CDS SPH_0730 NC_010380.1 677284 677562 D identified by glimmer; hypothetical protein 677284..677562 Streptococcus pneumoniae Hungary19A-6 6028604 YP_001694116.1 CDS SPH_0731 NC_010380.1 677547 677744 D identified by glimmer; hypothetical protein 677547..677744 Streptococcus pneumoniae Hungary19A-6 6027885 YP_001694117.1 CDS SPH_0732 NC_010380.1 678020 678244 R hypothetical protein complement(678020..678244) Streptococcus pneumoniae Hungary19A-6 6027992 YP_001694118.1 CDS SPH_0733 NC_010380.1 678477 684893 D identified by match to protein family HMM PF00082; match to protein family HMM PF00746; match to protein family HMM PF02225; match to protein family HMM PF05922; match to protein family HMM PF06280; match to protein family HMM TIGR01167; serine protease 678477..684893 Streptococcus pneumoniae Hungary19A-6 6027975 YP_001694119.1 CDS SPH_0735 NC_010380.1 685580 685825 R transposase complement(685580..685825) Streptococcus pneumoniae Hungary19A-6 6029667 YP_001694120.1 CDS SPH_0738 NC_010380.1 687333 687809 D identified by match to protein family HMM PF00359; phosphotransferase system sugar-specific EII component 687333..687809 Streptococcus pneumoniae Hungary19A-6 6028016 YP_001694121.1 CDS SPH_0739 NC_010380.1 687847 688152 D PTS system, galactose-specific IIB component 687847..688152 Streptococcus pneumoniae Hungary19A-6 6027940 YP_001694122.1 CDS SPH_0740 NC_010380.1 688200 689675 D identified by match to protein family HMM PF03611; phosphotransferase system sugar-specific EII component 688200..689675 Streptococcus pneumoniae Hungary19A-6 6030039 YP_001694123.1 CDS SPH_0741 NC_010380.1 690025 696726 D identified by match to protein family HMM PF00703; match to protein family HMM PF00746; match to protein family HMM PF02836; match to protein family HMM PF02837; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07532; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-galactosidase 690025..696726 Streptococcus pneumoniae Hungary19A-6 6029450 YP_001694124.1 CDS SPH_0742 NC_010380.1 696974 697597 R identified by glimmer; hypothetical protein complement(696974..697597) Streptococcus pneumoniae Hungary19A-6 6028163 YP_001694125.1 CDS SPH_0743 NC_010380.1 697585 697830 R identified by glimmer; hypothetical protein complement(697585..697830) Streptococcus pneumoniae Hungary19A-6 6028350 YP_001694126.1 CDS SPH_0744 NC_010380.1 697800 697967 D identified by glimmer; hypothetical protein 697800..697967 Streptococcus pneumoniae Hungary19A-6 6029688 YP_001694127.1 CDS SPH_0745 NC_010380.1 698041 698400 R hypothetical protein complement(698041..698400) Streptococcus pneumoniae Hungary19A-6 6028333 YP_001694128.1 CDS SPH_0748 NC_010380.1 699432 699989 D identified by match to protein family HMM PF06962; SAM-dependent methyltransferase 699432..699989 Streptococcus pneumoniae Hungary19A-6 6027943 YP_001694129.1 CDS SPH_0749 NC_010380.1 700096 700236 D hypothetical protein 700096..700236 Streptococcus pneumoniae Hungary19A-6 6027868 YP_001694130.1 CDS SPH_0752 NC_010380.1 702480 703340 D identified by match to protein family HMM PF03631; ribonuclease BN 702480..703340 Streptococcus pneumoniae Hungary19A-6 6028019 YP_001694131.1 CDS SPH_0753 NC_010380.1 703551 704261 D identified by match to protein family HMM PF02683; cytochrome c-type biogenesis protein 703551..704261 Streptococcus pneumoniae Hungary19A-6 6028434 YP_001694132.1 CDS SPH_0754 NC_010380.1 704281 704847 D identified by match to protein family HMM PF00578; match to protein family HMM PF08534; thioredoxin family protein 704281..704847 Streptococcus pneumoniae Hungary19A-6 6028267 YP_001694133.1 CDS SPH_0755 NC_010380.1 704858 705970 D identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; peptide methionine sulfoxide reductase MsrA/msrB 704858..705970 Streptococcus pneumoniae Hungary19A-6 6029283 YP_001694134.1 CDS SPH_0756 NC_010380.1 706418 707155 D identified by match to protein family HMM PF00072; match to protein family HMM PF00165; response regulator 706418..707155 Streptococcus pneumoniae Hungary19A-6 6028440 YP_001694135.1 CDS SPH_0757 NC_010380.1 707152 708843 D identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF02743; match to protein family HMM PF06580; histidine kinase 707152..708843 Streptococcus pneumoniae Hungary19A-6 6029185 YP_001694136.1 CDS SPH_0758 NC_010380.1 708959 709522 D identified by match to protein family HMM PF04260; match to protein family HMM TIGR01440; hypothetical protein 708959..709522 Streptococcus pneumoniae Hungary19A-6 6028448 YP_001694137.1 CDS zmpB NC_010380.1 709544 715246 D identified by match to protein family HMM PF00746; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM TIGR01167; zinc metalloprotease ZmpB 709544..715246 Streptococcus pneumoniae Hungary19A-6 6028839 YP_001694138.1 CDS SPH_0760 NC_010380.1 715321 717042 D identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553; chorismate binding enzyme 715321..717042 Streptococcus pneumoniae Hungary19A-6 6029202 YP_001694139.1 CDS SPH_0761 NC_010380.1 717043 717660 D hypothetical protein 717043..717660 Streptococcus pneumoniae Hungary19A-6 6028472 YP_001694140.1 CDS SPH_0762 NC_010380.1 717710 718636 D identified by match to protein family HMM PF01473; match to protein family HMM PF05901; Excalibur domain-containing protein 717710..718636 Streptococcus pneumoniae Hungary19A-6 6029789 YP_001694141.1 CDS SPH_0763 NC_010380.1 718835 719794 D identified by match to protein family HMM PF00480; match to protein family HMM TIGR00744; glucokinase (glucose kinase) 718835..719794 Streptococcus pneumoniae Hungary19A-6 6028186 YP_001694142.1 CDS thyA NC_010380.1 719892 720731 D ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 719892..720731 Streptococcus pneumoniae Hungary19A-6 6028827 YP_001694143.1 CDS SPH_0765 NC_010380.1 720779 720949 R hypothetical protein complement(720779..720949) Streptococcus pneumoniae Hungary19A-6 6029567 YP_001694144.1 CDS miaA NC_010380.1 721070 721954 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 721070..721954 Streptococcus pneumoniae Hungary19A-6 6029205 YP_001694145.1 CDS hflX NC_010380.1 721947 723185 D identified by match to protein family HMM PF01926; match to protein family HMM TIGR00231; match to protein family HMM TIGR03156; GTP-binding protein HflX 721947..723185 Streptococcus pneumoniae Hungary19A-6 6029378 YP_001694146.1 CDS SPH_0768 NC_010380.1 723178 723801 D cystathionine beta-lyase 723178..723801 Streptococcus pneumoniae Hungary19A-6 6028632 YP_001694147.1 CDS rnz NC_010380.1 723816 724745 D member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 723816..724745 Streptococcus pneumoniae Hungary19A-6 6028894 YP_001694148.1 CDS SPH_0770 NC_010380.1 724766 725521 D identified by match to protein family HMM PF00106; match to protein family HMM PF08659; oxidoreductase 724766..725521 Streptococcus pneumoniae Hungary19A-6 6028729 YP_001694149.1 CDS SPH_0771 NC_010380.1 725575 726543 R identified by match to protein family HMM PF00126; regulatory function on capsule expression complement(725575..726543) Streptococcus pneumoniae Hungary19A-6 6028889 YP_001694150.1 CDS SPH_0772 NC_010380.1 726547 726816 D identified by match to protein family HMM PF06014; hypothetical protein 726547..726816 Streptococcus pneumoniae Hungary19A-6 6029918 YP_001694151.1 CDS SPH_0773 NC_010380.1 726816 727196 D identified by match to protein family HMM PF00581; rhodanese family protein 726816..727196 Streptococcus pneumoniae Hungary19A-6 6029943 YP_001694152.1 CDS SPH_0774 NC_010380.1 727285 727512 D hypothetical protein 727285..727512 Streptococcus pneumoniae Hungary19A-6 6028376 YP_001694153.1 CDS SPH_0775 NC_010380.1 727552 728277 R identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A complement(727552..728277) Streptococcus pneumoniae Hungary19A-6 6030054 YP_001694154.1 CDS typA NC_010380.1 728439 730280 D identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394; GTP-binding protein TypA 728439..730280 Streptococcus pneumoniae Hungary19A-6 6029646 YP_001694155.1 CDS SPH_0777 NC_010380.1 730300 730554 D hypothetical protein 730300..730554 Streptococcus pneumoniae Hungary19A-6 6029037 YP_001694156.1 CDS SPH_0778 NC_010380.1 730918 731217 D identified by match to protein family HMM TIGR01653; bacteriocin 730918..731217 Streptococcus pneumoniae Hungary19A-6 6028216 YP_001694157.1 CDS SPH_0781 NC_010380.1 733309 733950 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 733309..733950 Streptococcus pneumoniae Hungary19A-6 6029477 YP_001694158.1 CDS murD NC_010380.1 734054 735406 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 734054..735406 Streptococcus pneumoniae Hungary19A-6 6029100 YP_001694159.1 CDS murG NC_010380.1 735408 736466 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 735408..736466 Streptococcus pneumoniae Hungary19A-6 6028949 YP_001694160.1 CDS SPH_0784 NC_010380.1 736476 737642 D identified by match to protein family HMM PF03799; match to protein family HMM PF08478; cell division protein DivIB 736476..737642 Streptococcus pneumoniae Hungary19A-6 6029723 YP_001694161.1 CDS pyrF NC_010380.1 737908 738609 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 737908..738609 Streptococcus pneumoniae Hungary19A-6 6028327 YP_001694162.1 CDS pyrE NC_010380.1 738643 739275 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 738643..739275 Streptococcus pneumoniae Hungary19A-6 6029027 YP_001694163.1 CDS SPH_0787 NC_010380.1 739736 739858 D identified by glimmer; hypothetical protein 739736..739858 Streptococcus pneumoniae Hungary19A-6 6027978 YP_001694164.1 CDS SPH_0788 NC_010380.1 739954 740718 D hypothetical protein 739954..740718 Streptococcus pneumoniae Hungary19A-6 6028968 YP_001694165.1 CDS SPH_0789 NC_010380.1 740718 741470 D lipoprotein 740718..741470 Streptococcus pneumoniae Hungary19A-6 6028183 YP_001694166.1 CDS SPH_0790 NC_010380.1 741474 742178 D hypothetical protein 741474..742178 Streptococcus pneumoniae Hungary19A-6 6029169 YP_001694167.1 CDS SPH_0791 NC_010380.1 742175 742822 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 742175..742822 Streptococcus pneumoniae Hungary19A-6 6028098 YP_001694168.1 CDS SPH_0792 NC_010380.1 742909 743775 R identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein complement(742909..743775) Streptococcus pneumoniae Hungary19A-6 6028462 YP_001694169.1 CDS SPH_0797 NC_010380.1 745234 745854 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; ABC transporter membrane-spanning permease - glutamine transport complement(745234..745854) Streptococcus pneumoniae Hungary19A-6 6029226 YP_001694170.1 CDS SPH_0798 NC_010380.1 746129 746275 D hypothetical protein 746129..746275 Streptococcus pneumoniae Hungary19A-6 6029748 YP_001694171.1 CDS lysS NC_010380.1 746403 747893 D class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 746403..747893 Streptococcus pneumoniae Hungary19A-6 6028155 YP_001694172.1 CDS SPH_0802 NC_010380.1 750209 750877 D identified by match to protein family HMM PF03070; TENA/THI-4 family protein 750209..750877 Streptococcus pneumoniae Hungary19A-6 6029500 YP_001694173.1 CDS SPH_0803 NC_010380.1 750932 751063 R identified by glimmer; hypothetical protein complement(750932..751063) Streptococcus pneumoniae Hungary19A-6 6028222 YP_001694174.1 CDS thiM NC_010380.1 751165 751947 D catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 751165..751947 Streptococcus pneumoniae Hungary19A-6 6027824 YP_001694175.1 CDS thiE1 NC_010380.1 751949 752578 D identified by match to protein family HMM PF02581; match to protein family HMM TIGR00693; thiamine-phosphate pyrophosphorylase 751949..752578 Streptococcus pneumoniae Hungary19A-6 6029586 YP_001694176.1 CDS SPH_0806 NC_010380.1 753137 753697 D ABC-type cobalt transport system, permease component 753137..753697 Streptococcus pneumoniae Hungary19A-6 6028967 YP_001694177.1 CDS SPH_0807 NC_010380.1 753698 755083 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein - cobalt or other cation transport 753698..755083 Streptococcus pneumoniae Hungary19A-6 6028474 YP_001694178.1 CDS SPH_0808 NC_010380.1 755085 755735 D hypothetical protein 755085..755735 Streptococcus pneumoniae Hungary19A-6 6028265 YP_001694179.1 CDS SPH_0809 NC_010380.1 755746 756438 D identified by match to protein family HMM PF03070; TENA/THI-4 family protein 755746..756438 Streptococcus pneumoniae Hungary19A-6 6028482 YP_001694180.1 CDS thiW NC_010380.1 756443 756967 D identified by match to protein family HMM TIGR02359; ThiW protein 756443..756967 Streptococcus pneumoniae Hungary19A-6 6030020 YP_001694181.1 CDS SPH_0811 NC_010380.1 756967 757770 D identified by match to protein family HMM PF02110; hydroxyethylthiazole kinase 756967..757770 Streptococcus pneumoniae Hungary19A-6 6030027 YP_001694182.1 CDS thiE NC_010380.1 757763 758395 D Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 757763..758395 Streptococcus pneumoniae Hungary19A-6 6028259 YP_001694183.1 CDS thiD NC_010380.1 758604 759395 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(758604..759395) Streptococcus pneumoniae Hungary19A-6 6028883 YP_001694184.1 CDS SPH_0814 NC_010380.1 759761 760156 D identified by match to protein family HMM PF03965; match to protein family HMM TIGR02698; CopY/TcrY family copper transport repressor 759761..760156 Streptococcus pneumoniae Hungary19A-6 6028495 YP_001694185.1 CDS SPH_0815 NC_010380.1 760167 760538 D hypothetical protein 760167..760538 Streptococcus pneumoniae Hungary19A-6 6029319 YP_001694186.1 CDS SPH_0816 NC_010380.1 760548 762791 D identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM PF08282; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525; copper-translocating P-type ATPase 760548..762791 Streptococcus pneumoniae Hungary19A-6 6029921 YP_001694187.1 CDS spxB NC_010380.1 762998 764773 D identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR02720; pyruvate oxidase 762998..764773 Streptococcus pneumoniae Hungary19A-6 6028647 YP_001694188.1 CDS SPH_0818 NC_010380.1 764884 765231 D identified by match to protein family HMM PF00903; glyoxalase 764884..765231 Streptococcus pneumoniae Hungary19A-6 6029973 YP_001694189.1 CDS SPH_0820 NC_010380.1 765888 766154 R transposase complement(765888..766154) Streptococcus pneumoniae Hungary19A-6 6028784 YP_001694190.1 CDS SPH_0822 NC_010380.1 766705 767313 R identified by glimmer; hypothetical protein complement(766705..767313) Streptococcus pneumoniae Hungary19A-6 6029832 YP_001694191.1 CDS SPH_0824 NC_010380.1 769060 769653 D identified by match to protein family HMM PF04131; NanE/NanK bifunctional enzyme 769060..769653 Streptococcus pneumoniae Hungary19A-6 6029571 YP_001694192.1 CDS SPH_0825 NC_010380.1 769654 770586 D identified by match to protein family HMM PF00528; protein LplB 769654..770586 Streptococcus pneumoniae Hungary19A-6 6027732 YP_001694193.1 CDS SPH_0826 NC_010380.1 770597 771526 D identified by match to protein family HMM PF00528; protein LplC 770597..771526 Streptococcus pneumoniae Hungary19A-6 6028533 YP_001694194.1 CDS SPH_0827 NC_010380.1 771540 772979 D hypothetical protein 771540..772979 Streptococcus pneumoniae Hungary19A-6 6029929 YP_001694195.1 CDS SPH_0828 NC_010380.1 773048 774625 D identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein 773048..774625 Streptococcus pneumoniae Hungary19A-6 6028739 YP_001694196.1 CDS SPH_0829 NC_010380.1 774727 776145 D dihydrolipoamide dehydrogenase 774727..776145 Streptococcus pneumoniae Hungary19A-6 6029775 YP_001694197.1 CDS SPH_0830 NC_010380.1 776167 776622 D identified by match to protein family HMM PF01230; diadenosine tetraphosphate 776167..776622 Streptococcus pneumoniae Hungary19A-6 6028113 YP_001694198.1 CDS SPH_0833 NC_010380.1 777127 777576 D identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 777127..777576 Streptococcus pneumoniae Hungary19A-6 6030022 YP_001694199.1 CDS SPH_0835 NC_010380.1 777904 778035 R hypothetical protein complement(777904..778035) Streptococcus pneumoniae Hungary19A-6 6029680 YP_001694200.1 CDS SPH_0836 NC_010380.1 778100 778381 D 6-phospho-beta-glucosidase 778100..778381 Streptococcus pneumoniae Hungary19A-6 6027996 YP_001694201.1 CDS manA NC_010380.1 778513 779457 D identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218; mannose-6-phosphate isomerase 778513..779457 Streptococcus pneumoniae Hungary19A-6 6029252 YP_001694202.1 CDS SPH_0838 NC_010380.1 779497 780363 R sodium-dependent transporter complement(779497..780363) Streptococcus pneumoniae Hungary19A-6 6028859 YP_001694203.1 CDS SPH_0841 NC_010380.1 781254 781463 R hypothetical protein complement(781254..781463) Streptococcus pneumoniae Hungary19A-6 6029996 YP_001694204.1 CDS SPH_0843 NC_010380.1 781514 782686 R identified by match to protein family HMM PF01134; match to protein family HMM PF03486; match to protein family HMM TIGR00275; hypothetical protein complement(781514..782686) Streptococcus pneumoniae Hungary19A-6 6029513 YP_001694205.1 CDS SPH_0844 NC_010380.1 782745 783590 R identified by match to protein family HMM PF02645; hypothetical protein complement(782745..783590) Streptococcus pneumoniae Hungary19A-6 6028890 YP_001694206.1 CDS SPH_0845 NC_010380.1 783715 784272 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 783715..784272 Streptococcus pneumoniae Hungary19A-6 6027908 YP_001694207.1 CDS SPH_0846 NC_010380.1 784291 784758 D identified by match to protein family HMM PF00383; ComE operon protein 2 784291..784758 Streptococcus pneumoniae Hungary19A-6 6029143 YP_001694208.1 CDS upp NC_010380.1 784826 785476 D Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 784826..785476 Streptococcus pneumoniae Hungary19A-6 6029399 YP_001694209.1 CDS clpP NC_010380.1 785650 786240 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 785650..786240 Streptococcus pneumoniae Hungary19A-6 6028624 YP_001694210.1 CDS SPH_0849 NC_010380.1 786319 786567 D hypothetical protein 786319..786567 Streptococcus pneumoniae Hungary19A-6 6029770 YP_001694211.1 CDS SPH_0850 NC_010380.1 786669 787829 D identified by match to protein family HMM PF01094; ABC transporter substrate-binding protein - branched chain amino acid transport 786669..787829 Streptococcus pneumoniae Hungary19A-6 6028922 YP_001694212.1 CDS SPH_0851 NC_010380.1 788097 788966 D identified by match to protein family HMM PF02653; high-affinity branched-chain amino acid transport system permeaseprotein LivH (LIV-I protein H) 788097..788966 Streptococcus pneumoniae Hungary19A-6 6027994 YP_001694213.1 CDS SPH_0852 NC_010380.1 788970 789926 D identified by match to protein family HMM PF02653; ABC transporter membrane-spanning permease - branched chain amino acid transport 788970..789926 Streptococcus pneumoniae Hungary19A-6 6028212 YP_001694214.1 CDS SPH_0853 NC_010380.1 789926 790690 D identified by match to protein family HMM PF00005; high-affinity branched-chain amino acid transport ATP-binding proteinlivg (LIV-I protein G) 789926..790690 Streptococcus pneumoniae Hungary19A-6 6028769 YP_001694215.1 CDS SPH_0854 NC_010380.1 790690 791400 D identified by match to protein family HMM PF00005; high-affinity branched-chain amino acid transport ATP-binding proteinlivf (LIV-I protein F) 790690..791400 Streptococcus pneumoniae Hungary19A-6 6029511 YP_001694216.1 CDS SPH_0855 NC_010380.1 791707 792363 D identified by match to protein family HMM PF00571; AcuB family protein 791707..792363 Streptococcus pneumoniae Hungary19A-6 6028097 YP_001694217.1 CDS prfB NC_010380.1 792577 793566 D recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 792577..793566 Streptococcus pneumoniae Hungary19A-6 6028017 YP_001694218.1 CDS ftsE NC_010380.1 793584 794276 D identified by match to protein family HMM PF00005; match to protein family HMM TIGR02673; cell division ATP-binding protein FtsE 793584..794276 Streptococcus pneumoniae Hungary19A-6 6028982 YP_001694219.1 CDS SPH_0858 NC_010380.1 794269 795195 D identified by match to protein family HMM PF02687; cell division ABC transporter permease FtsX 794269..795195 Streptococcus pneumoniae Hungary19A-6 6029381 YP_001694220.1 CDS SPH_0859 NC_010380.1 795481 797661 D identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR02003; pts system, IIBC component 795481..797661 Streptococcus pneumoniae Hungary19A-6 6029818 YP_001694221.1 CDS SPH_0860 NC_010380.1 797713 798528 D identified by match to protein family HMM PF03372; metal-dependent hydrolase 797713..798528 Streptococcus pneumoniae Hungary19A-6 6027729 YP_001694222.1 CDS SPH_0861 NC_010380.1 798668 800011 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; ATP-dependent RNA helicase 798668..800011 Streptococcus pneumoniae Hungary19A-6 6027900 YP_001694223.1 CDS metK NC_010380.1 800226 801416 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 800226..801416 Streptococcus pneumoniae Hungary19A-6 6029799 YP_001694224.1 CDS SPH_0863 NC_010380.1 801969 802904 D dihydroorotate oxidase; dhodehase; dhodase; dhod; catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 801969..802904 Streptococcus pneumoniae Hungary19A-6 6029146 YP_001694225.1 CDS holA NC_010380.1 802938 803975 D required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 802938..803975 Streptococcus pneumoniae Hungary19A-6 6029133 YP_001694226.1 CDS SPH_0865 NC_010380.1 804148 804753 D identified by match to protein family HMM PF00081; match to protein family HMM PF02777; superoxide dismutase [Mn] (general stress protein 24)(GSP24) 804148..804753 Streptococcus pneumoniae Hungary19A-6 6029468 YP_001694227.1 CDS SPH_0866 NC_010380.1 804910 805440 D identified by match to protein family HMM PF06265; transcriptional regulator 804910..805440 Streptococcus pneumoniae Hungary19A-6 6028170 YP_001694228.1 CDS SPH_0867 NC_010380.1 805461 806546 D 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 805461..806546 Streptococcus pneumoniae Hungary19A-6 6027845 YP_001694229.1 CDS SPH_0868 NC_010380.1 806546 807028 D identified by match to protein family HMM PF04892; VanZ family protein 806546..807028 Streptococcus pneumoniae Hungary19A-6 6028505 YP_001694230.1 CDS SPH_0869 NC_010380.1 807030 808571 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 807030..808571 Streptococcus pneumoniae Hungary19A-6 6027853 YP_001694231.1 CDS SPH_0870 NC_010380.1 808627 809430 R identified by match to protein family HMM PF00160; peptidyl-prolyl cis-trans isomerase complement(808627..809430) Streptococcus pneumoniae Hungary19A-6 6027967 YP_001694232.1 CDS SPH_0871 NC_010380.1 809513 809734 R hypothetical protein complement(809513..809734) Streptococcus pneumoniae Hungary19A-6 6028962 YP_001694233.1 CDS SPH_0872 NC_010380.1 810213 810422 R identified by glimmer; hypothetical protein complement(810213..810422) Streptococcus pneumoniae Hungary19A-6 6029165 YP_001694234.1 CDS rpsP NC_010380.1 810592 810864 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 810592..810864 Streptococcus pneumoniae Hungary19A-6 6028823 YP_001694235.1 CDS SPH_0874 NC_010380.1 810884 811123 D hypothetical protein 810884..811123 Streptococcus pneumoniae Hungary19A-6 6029081 YP_001694236.1 CDS SPH_0875 NC_010380.1 811700 812488 D identified by match to protein family HMM PF00561; alpha/beta hydrolase 811700..812488 Streptococcus pneumoniae Hungary19A-6 6029736 YP_001694237.1 CDS rimM NC_010380.1 812519 813037 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 812519..813037 Streptococcus pneumoniae Hungary19A-6 6029844 YP_001694238.1 CDS trmD NC_010380.1 813027 813746 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 813027..813746 Streptococcus pneumoniae Hungary19A-6 6030029 YP_001694239.1 CDS SPH_0878 NC_010380.1 813758 814096 D identified by match to protein family HMM PF03477; oxygen-sensitive ribonucleoside-triphosphate reductase 813758..814096 Streptococcus pneumoniae Hungary19A-6 6029654 YP_001694240.1 CDS SPH_0879 NC_010380.1 814126 814446 R hypothetical protein complement(814126..814446) Streptococcus pneumoniae Hungary19A-6 6028985 YP_001694241.1 CDS SPH_0881 NC_010380.1 814544 814759 D hypothetical protein 814544..814759 Streptococcus pneumoniae Hungary19A-6 6027883 YP_001694242.1 CDS SPH_0880 NC_010380.1 814756 814902 R chlorohydrolase complement(814756..814902) Streptococcus pneumoniae Hungary19A-6 6029900 YP_001694243.1 CDS SPH_0882 NC_010380.1 814963 815499 R identified by match to protein family HMM PF02632; biotin synthase complement(814963..815499) Streptococcus pneumoniae Hungary19A-6 6028383 YP_001694244.1 CDS gor NC_010380.1 815696 817042 R catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase complement(815696..817042) Streptococcus pneumoniae Hungary19A-6 6028550 YP_001694245.1 CDS SPH_0884 NC_010380.1 817307 818506 D identified by match to protein family HMM TIGR01730; membrane-fusion protein 817307..818506 Streptococcus pneumoniae Hungary19A-6 6029051 YP_001694246.1 CDS SPH_0885 NC_010380.1 818490 819191 D identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease MacB 818490..819191 Streptococcus pneumoniae Hungary19A-6 6029079 YP_001694247.1 CDS SPH_0886 NC_010380.1 819193 820452 D identified by match to protein family HMM PF02687; peptide ABC transporter permease 819193..820452 Streptococcus pneumoniae Hungary19A-6 6029907 YP_001694248.1 CDS metG NC_010380.1 820576 822573 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 820576..822573 Streptococcus pneumoniae Hungary19A-6 6028120 YP_001694249.1 CDS SPH_0888 NC_010380.1 822645 823901 R identified by match to protein family HMM PF01610; transposase complement(822645..823901) Streptococcus pneumoniae Hungary19A-6 6030012 YP_001694250.1 CDS SPH_0889 NC_010380.1 824046 824282 D chlorohydrolase 824046..824282 Streptococcus pneumoniae Hungary19A-6 6028652 YP_001694251.1 CDS SPH_0890 NC_010380.1 824372 824692 D identified by match to protein family HMM PF03551; PadR family transcriptional regulator 824372..824692 Streptococcus pneumoniae Hungary19A-6 6028898 YP_001694252.1 CDS SPH_0891 NC_010380.1 824696 825511 D hypothetical protein 824696..825511 Streptococcus pneumoniae Hungary19A-6 6029407 YP_001694253.1 CDS SPH_0892 NC_010380.1 825501 825614 D identified by glimmer; hypothetical protein 825501..825614 Streptococcus pneumoniae Hungary19A-6 6027747 YP_001694254.1 CDS SPH_0893 NC_010380.1 825586 826512 D identified by match to protein family HMM PF00248; oxidoreductase, aldo/keto reductase 825586..826512 Streptococcus pneumoniae Hungary19A-6 6029386 YP_001694255.1 CDS SPH_0894 NC_010380.1 826612 826848 D hypothetical protein 826612..826848 Streptococcus pneumoniae Hungary19A-6 6030032 YP_001694256.1 CDS fabG NC_010380.1 826841 827539 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 826841..827539 Streptococcus pneumoniae Hungary19A-6 6028193 YP_001694257.1 CDS SPH_0896 NC_010380.1 827550 828050 D identified by match to protein family HMM PF00293; MutT/nudix family protein 827550..828050 Streptococcus pneumoniae Hungary19A-6 6029056 YP_001694258.1 CDS SPH_0897 NC_010380.1 828028 828897 D identified by match to protein family HMM PF02896; PEP-utilizing enzyme family protein 828028..828897 Streptococcus pneumoniae Hungary19A-6 6028036 YP_001694259.1 CDS SPH_0898 NC_010380.1 828872 829312 D identified by match to protein family HMM PF06171; hypothetical protein 828872..829312 Streptococcus pneumoniae Hungary19A-6 6028926 YP_001694260.1 CDS SPH_0899 NC_010380.1 829435 831981 D identified by match to protein family HMM PF01433; aminopeptidase 829435..831981 Streptococcus pneumoniae Hungary19A-6 6028931 YP_001694261.1 CDS SPH_0900 NC_010380.1 832090 832764 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; transcriptional regulatory protein CiaR 832090..832764 Streptococcus pneumoniae Hungary19A-6 6029813 YP_001694262.1 CDS SPH_0901 NC_010380.1 832754 834088 D identified by match to protein family HMM PF00512; match to protein family HMM PF02518; sensor protein CiaH 832754..834088 Streptococcus pneumoniae Hungary19A-6 6028119 YP_001694263.1 CDS SPH_0902 NC_010380.1 834122 834409 R hypothetical protein complement(834122..834409) Streptococcus pneumoniae Hungary19A-6 6027768 YP_001694264.1 CDS SPH_0903 NC_010380.1 834549 835478 D identified by match to protein family HMM PF01136; protease 834549..835478 Streptococcus pneumoniae Hungary19A-6 6029261 YP_001694265.1 CDS SPH_0904 NC_010380.1 835678 838128 D unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 835678..838128 Streptococcus pneumoniae Hungary19A-6 6030001 YP_001694266.1 CDS SPH_0905 NC_010380.1 838138 839388 D identified by match to protein family HMM PF01098; RodA 838138..839388 Streptococcus pneumoniae Hungary19A-6 6029635 YP_001694267.1 CDS SPH_0906 NC_010380.1 839399 839953 D identified by match to protein family HMM PF01965; match to protein family HMM TIGR01383; 4-methyl-5 839399..839953 Streptococcus pneumoniae Hungary19A-6 6029134 YP_001694268.1 CDS SPH_0907 NC_010380.1 840038 840601 D identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; phosphoglycolate phosphatase 840038..840601 Streptococcus pneumoniae Hungary19A-6 6028266 YP_001694269.1 CDS gyrB NC_010380.1 840616 842562 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 840616..842562 Streptococcus pneumoniae Hungary19A-6 6027869 YP_001694270.1 CDS ezrA NC_010380.1 842644 844371 D acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 842644..844371 Streptococcus pneumoniae Hungary19A-6 6028763 YP_001694271.1 CDS SPH_0910 NC_010380.1 845358 845624 D transposase 845358..845624 Streptococcus pneumoniae Hungary19A-6 6028094 YP_001694272.1 CDS SPH_0913 NC_010380.1 846165 846515 R identified by match to protein family HMM PF05717; transposase complement(846165..846515) Streptococcus pneumoniae Hungary19A-6 6027746 YP_001694273.1 CDS SPH_0916 NC_010380.1 847545 848081 R transposase complement(847545..848081) Streptococcus pneumoniae Hungary19A-6 6029904 YP_001694274.1 CDS SPH_0917 NC_010380.1 848217 848516 R identified by match to protein family HMM PF08860; hypothetical protein complement(848217..848516) Streptococcus pneumoniae Hungary19A-6 6027973 YP_001694275.1 CDS SPH_0918 NC_010380.1 848681 849136 R identified by match to protein family HMM PF00293; MutT/nudix family protein complement(848681..849136) Streptococcus pneumoniae Hungary19A-6 6028413 YP_001694276.1 CDS SPH_0920 NC_010380.1 850265 852523 R identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; negative regulator of genetic competence ClpC/mecB complement(850265..852523) Streptococcus pneumoniae Hungary19A-6 6029948 YP_001694277.1 CDS SPH_0921 NC_010380.1 852752 852982 R identified by match to protein family HMM PF08796; hypothetical protein complement(852752..852982) Streptococcus pneumoniae Hungary19A-6 6028595 YP_001694278.1 CDS SPH_0922 NC_010380.1 853172 853855 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 853172..853855 Streptococcus pneumoniae Hungary19A-6 6029633 YP_001694279.1 CDS SPH_0923 NC_010380.1 853855 854589 D identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 853855..854589 Streptococcus pneumoniae Hungary19A-6 6029439 YP_001694280.1 CDS SPH_0924 NC_010380.1 854722 855600 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 854722..855600 Streptococcus pneumoniae Hungary19A-6 6028464 YP_001694281.1 CDS SPH_0925 NC_010380.1 855742 856614 D identified by match to protein family HMM PF01256; match to protein family HMM TIGR00196; YjeF homolog, C-terminus 855742..856614 Streptococcus pneumoniae Hungary19A-6 6029521 YP_001694282.1 CDS rpiA NC_010380.1 856896 857579 D Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 856896..857579 Streptococcus pneumoniae Hungary19A-6 6029712 YP_001694283.1 CDS deoB NC_010380.1 857593 858804 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 857593..858804 Streptococcus pneumoniae Hungary19A-6 6029072 YP_001694284.1 CDS SPH_0928 NC_010380.1 858806 859348 D identified by match to protein family HMM PF08002; hypothetical protein 858806..859348 Streptococcus pneumoniae Hungary19A-6 6029728 YP_001694285.1 CDS SPH_0929 NC_010380.1 859364 860173 D catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 859364..860173 Streptococcus pneumoniae Hungary19A-6 6029565 YP_001694286.1 CDS SPH_0930 NC_010380.1 860649 861044 D identified by glimmer; hypothetical protein 860649..861044 Streptococcus pneumoniae Hungary19A-6 6027965 YP_001694287.1 CDS SPH_0931 NC_010380.1 861054 861629 D identified by glimmer; hypothetical protein 861054..861629 Streptococcus pneumoniae Hungary19A-6 6029911 YP_001694288.1 CDS SPH_0932 NC_010380.1 861687 862076 D identified by glimmer; hypothetical protein 861687..862076 Streptococcus pneumoniae Hungary19A-6 6029935 YP_001694289.1 CDS SPH_0933 NC_010380.1 862272 862385 D identified by glimmer; hypothetical protein 862272..862385 Streptococcus pneumoniae Hungary19A-6 6027955 YP_001694290.1 CDS deoD NC_010380.1 862820 863530 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 862820..863530 Streptococcus pneumoniae Hungary19A-6 6029774 YP_001694291.1 CDS SPH_0935 NC_010380.1 863553 864077 R topology modulation protein complement(863553..864077) Streptococcus pneumoniae Hungary19A-6 6028564 YP_001694292.1 CDS rpsT NC_010380.1 864130 864366 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(864130..864366) Streptococcus pneumoniae Hungary19A-6 6029430 YP_001694293.1 CDS coaA NC_010380.1 864434 865354 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(864434..865354) Streptococcus pneumoniae Hungary19A-6 6027953 YP_001694294.1 CDS SPH_0938 NC_010380.1 865552 865956 D identified by glimmer; hypothetical protein 865552..865956 Streptococcus pneumoniae Hungary19A-6 6028720 YP_001694295.1 CDS SPH_0939 NC_010380.1 866047 866166 D identified by glimmer; hypothetical protein 866047..866166 Streptococcus pneumoniae Hungary19A-6 6028289 YP_001694296.1 CDS SPH_0940 NC_010380.1 866172 866753 D identified by match to protein family HMM PF05175; methyltransferase small subunit 866172..866753 Streptococcus pneumoniae Hungary19A-6 6029232 YP_001694297.1 CDS SPH_0941 NC_010380.1 866750 868027 D Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 866750..868027 Streptococcus pneumoniae Hungary19A-6 6028362 YP_001694298.1 CDS deoC NC_010380.1 868047 868709 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 868047..868709 Streptococcus pneumoniae Hungary19A-6 6029620 YP_001694299.1 CDS cdd NC_010380.1 868696 869085 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 868696..869085 Streptococcus pneumoniae Hungary19A-6 6029151 YP_001694300.1 CDS SPH_0944 NC_010380.1 869175 870227 D identified by match to protein family HMM PF02608; lipoprotein 869175..870227 Streptococcus pneumoniae Hungary19A-6 6029387 YP_001694301.1 CDS SPH_0945 NC_010380.1 870371 871906 D identified by match to protein family HMM PF00005; ribose import ATP-binding protein RbsA 870371..871906 Streptococcus pneumoniae Hungary19A-6 6028092 YP_001694302.1 CDS SPH_0946 NC_010380.1 871899 872957 D identified by match to protein family HMM PF02653; ABC transporter membrane-spanning permease - ribose/galactose transport 871899..872957 Streptococcus pneumoniae Hungary19A-6 6029945 YP_001694303.1 CDS SPH_0947 NC_010380.1 872960 873916 D identified by match to protein family HMM PF02653; ABC transporter membrane-spanning permease - ribose/galactose transport 872960..873916 Streptococcus pneumoniae Hungary19A-6 6029087 YP_001694304.1 CDS SPH_0950 NC_010380.1 874516 875349 D identified by match to protein family HMM PF00665; integrase core subunit 874516..875349 Streptococcus pneumoniae Hungary19A-6 6028887 YP_001694305.1 CDS SPH_0951 NC_010380.1 875394 876035 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY complement(875394..876035) Streptococcus pneumoniae Hungary19A-6 6028003 YP_001694306.1 CDS parE NC_010380.1 876171 878114 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 876171..878114 Streptococcus pneumoniae Hungary19A-6 6028370 YP_001694307.1 CDS SPH_0953 NC_010380.1 878235 878360 D identified by glimmer; hypothetical protein 878235..878360 Streptococcus pneumoniae Hungary19A-6 6028698 YP_001694308.1 CDS parC NC_010380.1 878525 881005 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 878525..881005 Streptococcus pneumoniae Hungary19A-6 6027881 YP_001694309.1 CDS ilvE NC_010380.1 881137 882159 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 881137..882159 Streptococcus pneumoniae Hungary19A-6 6027898 YP_001694310.1 CDS SPH_0956 NC_010380.1 882215 882919 D hypothetical protein 882215..882919 Streptococcus pneumoniae Hungary19A-6 6028199 YP_001694311.1 CDS SPH_0957 NC_010380.1 882984 883673 D identified by match to protein family HMM PF06149; permease 882984..883673 Streptococcus pneumoniae Hungary19A-6 6028033 YP_001694312.1 CDS SPH_0958 NC_010380.1 883670 884593 D identified by match to protein family HMM PF06166; permease 883670..884593 Streptococcus pneumoniae Hungary19A-6 6029238 YP_001694313.1 CDS pcp NC_010380.1 884608 885252 D catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 884608..885252 Streptococcus pneumoniae Hungary19A-6 6028184 YP_001694314.1 CDS SPH_0960 NC_010380.1 885420 885650 D hypothetical protein 885420..885650 Streptococcus pneumoniae Hungary19A-6 6028861 YP_001694315.1 CDS rpsA NC_010380.1 886022 887224 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 886022..887224 Streptococcus pneumoniae Hungary19A-6 6028364 YP_001694316.1 CDS SPH_0967 NC_010380.1 888829 889326 D GAF domain-containing protein 888829..889326 Streptococcus pneumoniae Hungary19A-6 6028160 YP_001694317.1 CDS SPH_0968 NC_010380.1 889326 890981 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 889326..890981 Streptococcus pneumoniae Hungary19A-6 6029743 YP_001694318.1 CDS SPH_0969 NC_010380.1 891081 891203 D hypothetical protein 891081..891203 Streptococcus pneumoniae Hungary19A-6 6029174 YP_001694319.1 CDS sufC NC_010380.1 891352 892122 D identified by match to protein family HMM PF00005; match to protein family HMM TIGR01978; FeS assembly ATPase SufC 891352..892122 Streptococcus pneumoniae Hungary19A-6 6029457 YP_001694320.1 CDS sufD NC_010380.1 892150 893412 D identified by match to protein family HMM PF01458; match to protein family HMM TIGR01981; FeS assembly protein SufD 892150..893412 Streptococcus pneumoniae Hungary19A-6 6028990 YP_001694321.1 CDS SPH_0972 NC_010380.1 893423 894649 D selenocysteine lyase; Selenocysteine reductase; Selenocysteine beta-lyase; SCL; identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM TIGR01979; cysteine desulfurase 893423..894649 Streptococcus pneumoniae Hungary19A-6 6029619 YP_001694322.1 CDS SPH_0973 NC_010380.1 894636 895076 D identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994; NifU family SUF system FeS assembly protein 894636..895076 Streptococcus pneumoniae Hungary19A-6 6029006 YP_001694323.1 CDS sufB NC_010380.1 895130 896542 D identified by match to protein family HMM PF01458; match to protein family HMM TIGR01980; FeS assembly protein SufB 895130..896542 Streptococcus pneumoniae Hungary19A-6 6029114 YP_001694324.1 CDS SPH_0975 NC_010380.1 896546 896728 D identified by glimmer; hypothetical protein 896546..896728 Streptococcus pneumoniae Hungary19A-6 6029082 YP_001694325.1 CDS SPH_0976 NC_010380.1 896773 898014 R identified by match to protein family HMM PF00144; match to protein family HMM PF00768; match to protein family HMM PF07943; penicillin-binding protein 3 complement(896773..898014) Streptococcus pneumoniae Hungary19A-6 6029686 YP_001694326.1 CDS SPH_0977 NC_010380.1 898195 899226 D identified by match to protein family HMM PF01594; membrane protein 898195..899226 Streptococcus pneumoniae Hungary19A-6 6029176 YP_001694327.1 CDS SPH_0979 NC_010380.1 900538 901278 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; transcriptional repressor of the fructose operon 900538..901278 Streptococcus pneumoniae Hungary19A-6 6028369 YP_001694328.1 CDS pfkB NC_010380.1 901275 902186 D identified by match to protein family HMM PF00294; match to protein family HMM TIGR03168; 1-phosphofructokinase 901275..902186 Streptococcus pneumoniae Hungary19A-6 6027748 YP_001694329.1 CDS SPH_0981 NC_010380.1 902183 904135 D identified by match to protein family HMM PF00359; match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR00848; match to protein family HMM TIGR01427; PTS system, fructose family, IIC subunit 902183..904135 Streptococcus pneumoniae Hungary19A-6 6027690 YP_001694330.1 CDS SPH_0982 NC_010380.1 904156 904305 D identified by glimmer; hypothetical protein 904156..904305 Streptococcus pneumoniae Hungary19A-6 6028589 YP_001694331.1 CDS SPH_0983 NC_010380.1 904299 906524 D identified by match to protein family HMM PF01580; DNA translocase FtsK 904299..906524 Streptococcus pneumoniae Hungary19A-6 6028426 YP_001694332.1 CDS SPH_0984 NC_010380.1 906569 907003 R hypothetical protein complement(906569..907003) Streptococcus pneumoniae Hungary19A-6 6028789 YP_001694333.1 CDS SPH_0985 NC_010380.1 907141 908283 D identified by match to protein family HMM PF00266; cysteine desulfurase 907141..908283 Streptococcus pneumoniae Hungary19A-6 6029810 YP_001694334.1 CDS thiI NC_010380.1 908292 909506 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 908292..909506 Streptococcus pneumoniae Hungary19A-6 6027735 YP_001694335.1 CDS SPH_0987 NC_010380.1 909643 910467 D identified by match to protein family HMM PF00756; esterase 909643..910467 Streptococcus pneumoniae Hungary19A-6 6027970 YP_001694336.1 CDS SPH_0988 NC_010380.1 910489 910824 D identified by glimmer; hypothetical protein 910489..910824 Streptococcus pneumoniae Hungary19A-6 6028240 YP_001694337.1 CDS SPH_0989 NC_010380.1 910821 911228 D identified by glimmer; hypothetical protein 910821..911228 Streptococcus pneumoniae Hungary19A-6 6029492 YP_001694338.1 CDS SPH_0990 NC_010380.1 911241 912407 D carbamoylphosphate synthase large subunit 911241..912407 Streptococcus pneumoniae Hungary19A-6 6028386 YP_001694339.1 CDS SPH_0991 NC_010380.1 912667 912792 D identified by glimmer; hypothetical protein 912667..912792 Streptococcus pneumoniae Hungary19A-6 6029191 YP_001694340.1 CDS SPH_0992 NC_010380.1 912915 914408 D identified by match to protein family HMM PF02384; type I restriction modification enzyme methylase subunit 912915..914408 Streptococcus pneumoniae Hungary19A-6 6027756 YP_001694341.1 CDS SPH_0993 NC_010380.1 914421 915338 D identified by match to protein family HMM PF01420; type I restriction enzyme EcoBI specificity protein (S protein)(S.EcoBI) 914421..915338 Streptococcus pneumoniae Hungary19A-6 6028891 YP_001694342.1 CDS SPH_0994 NC_010380.1 915430 915666 D hypothetical protein 915430..915666 Streptococcus pneumoniae Hungary19A-6 6029596 YP_001694343.1 CDS SPH_0995 NC_010380.1 915663 916076 D identified by match to protein family HMM PF05012; match to protein family HMM TIGR01550; prophage maintenance system killer protein 915663..916076 Streptococcus pneumoniae Hungary19A-6 6030049 YP_001694344.1 CDS SPH_0996 NC_010380.1 916194 917159 D identified by match to protein family HMM PF00589; match to protein family HMM PF02899; phage integrase integrase/recombinase 916194..917159 Streptococcus pneumoniae Hungary19A-6 6029453 YP_001694345.1 CDS SPH_0997 NC_010380.1 917193 918215 D identified by match to protein family HMM PF01420; restriction modification system DNA specificity subunit 917193..918215 Streptococcus pneumoniae Hungary19A-6 6027920 YP_001694346.1 CDS SPH_0998 NC_010380.1 918444 921794 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04313; match to protein family HMM PF04851; type I restriction-modification system R subunit 918444..921794 Streptococcus pneumoniae Hungary19A-6 6028024 YP_001694347.1 CDS SPH_0999 NC_010380.1 922065 922220 D chlorohydrolase 922065..922220 Streptococcus pneumoniae Hungary19A-6 6030088 YP_001694348.1 CDS SPH_1000 NC_010380.1 922337 922807 R identified by match to protein family HMM PF01316; match to protein family HMM PF02863; arginine repressor ArgR complement(922337..922807) Streptococcus pneumoniae Hungary19A-6 6029144 YP_001694349.1 CDS SPH_1001 NC_010380.1 922824 925097 R x-pro dipeptidyl-peptidase; x-prolyl-dipeptidyl aminopeptidase; x-pdap; catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase complement(922824..925097) Streptococcus pneumoniae Hungary19A-6 6027800 YP_001694350.1 CDS dnaE NC_010380.1 925445 928546 D Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 925445..928546 Streptococcus pneumoniae Hungary19A-6 6029388 YP_001694351.1 CDS pfkA NC_010380.1 928629 929636 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 928629..929636 Streptococcus pneumoniae Hungary19A-6 6028627 YP_001694352.1 CDS pyk NC_010380.1 929695 931200 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 929695..931200 Streptococcus pneumoniae Hungary19A-6 6028875 YP_001694353.1 CDS SPH_1005 NC_010380.1 931420 931608 R identified by glimmer; hypothetical protein complement(931420..931608) Streptococcus pneumoniae Hungary19A-6 6028630 YP_001694354.1 CDS SPH_1007 NC_010380.1 932935 933807 D lipoprotein 932935..933807 Streptococcus pneumoniae Hungary19A-6 6028251 YP_001694355.1 CDS SPH_1008 NC_010380.1 933914 934297 R mobile genetic element complement(933914..934297) Streptococcus pneumoniae Hungary19A-6 6029154 YP_001694356.1 CDS SPH_1009 NC_010380.1 934440 934751 D hypothetical protein 934440..934751 Streptococcus pneumoniae Hungary19A-6 6029504 YP_001694357.1 CDS SPH_1010 NC_010380.1 934755 935471 D hypothetical protein 934755..935471 Streptococcus pneumoniae Hungary19A-6 6028681 YP_001694358.1 CDS SPH_1011 NC_010380.1 935601 936416 R identified by match to protein family HMM PF09323; ABC transporter substrate-binding protein complement(935601..936416) Streptococcus pneumoniae Hungary19A-6 6028873 YP_001694359.1 CDS SPH_1012 NC_010380.1 936413 937318 R identified by match to protein family HMM PF03773; permease complement(936413..937318) Streptococcus pneumoniae Hungary19A-6 6029068 YP_001694360.1 CDS SPH_1013 NC_010380.1 937319 937450 R identified by glimmer; hypothetical protein complement(937319..937450) Streptococcus pneumoniae Hungary19A-6 6029696 YP_001694361.1 CDS SPH_1014 NC_010380.1 937532 939904 D identified by match to protein family HMM PF00575; S1 RNA-binding domain-containing protein 937532..939904 Streptococcus pneumoniae Hungary19A-6 6029030 YP_001694362.1 CDS SPH_1015 NC_010380.1 939891 940340 D identified by match to protein family HMM PF03926; hypothetical protein 939891..940340 Streptococcus pneumoniae Hungary19A-6 6028660 YP_001694363.1 CDS SPH_1016 NC_010380.1 940399 940671 D identified by match to protein family HMM PF04024; PspC domain-containing protein 940399..940671 Streptococcus pneumoniae Hungary19A-6 6029663 YP_001694364.1 CDS SPH_1017 NC_010380.1 940719 940883 R identified by glimmer; hypothetical protein complement(940719..940883) Streptococcus pneumoniae Hungary19A-6 6028396 YP_001694365.1 CDS SPH_1018 NC_010380.1 941025 941216 R identified by glimmer; hypothetical protein complement(941025..941216) Streptococcus pneumoniae Hungary19A-6 6028099 YP_001694366.1 CDS SPH_1019 NC_010380.1 941644 942402 D identified by match to protein family HMM PF00005; bacitracin export ATP-binding protein BceA 941644..942402 Streptococcus pneumoniae Hungary19A-6 6027894 YP_001694367.1 CDS SPH_1020 NC_010380.1 942404 944392 D identified by match to protein family HMM PF02687; peptide ABC transporter permease 942404..944392 Streptococcus pneumoniae Hungary19A-6 6029531 YP_001694368.1 CDS SPH_1021 NC_010380.1 944434 945024 R identified by match to protein family HMM PF01988; hypothetical protein complement(944434..945024) Streptococcus pneumoniae Hungary19A-6 6029858 YP_001694369.1 CDS SPH_1024 NC_010380.1 946332 946445 R hypothetical protein complement(946332..946445) Streptococcus pneumoniae Hungary19A-6 6027938 YP_001694370.1 CDS SPH_1026 NC_010380.1 946806 948281 D identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM PF01276; match to protein family HMM PF03711; arginine decarboxylase 946806..948281 Streptococcus pneumoniae Hungary19A-6 6028853 YP_001694371.1 CDS speE NC_010380.1 949217 950077 D catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 949217..950077 Streptococcus pneumoniae Hungary19A-6 6028249 YP_001694372.1 CDS lys NC_010380.1 950074 951333 D identified by match to protein family HMM PF03435; saccharopine dehydrogenase 950074..951333 Streptococcus pneumoniae Hungary19A-6 6029233 YP_001694373.1 CDS nspC NC_010380.1 951333 952460 D identified by match to protein family HMM PF00278; match to protein family HMM TIGR01047; carboxynorspermidine decarboxylase 951333..952460 Streptococcus pneumoniae Hungary19A-6 6027762 YP_001694374.1 CDS aguA NC_010380.1 952457 953542 D catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis; agmatine deiminase 952457..953542 Streptococcus pneumoniae Hungary19A-6 6028862 YP_001694375.1 CDS aguB NC_010380.1 953552 954427 D identified by match to protein family HMM PF00795; match to protein family HMM TIGR03381; N-carbamoylputrescine amidase 953552..954427 Streptococcus pneumoniae Hungary19A-6 6028301 YP_001694376.1 CDS SPH_1032 NC_010380.1 954607 955416 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(954607..955416) Streptococcus pneumoniae Hungary19A-6 6027874 YP_001694377.1 CDS SPH_1033 NC_010380.1 955688 955909 D hypothetical protein 955688..955909 Streptococcus pneumoniae Hungary19A-6 6027794 YP_001694378.1 CDS SPH_1034 NC_010380.1 955963 956634 D identified by match to protein family HMM PF02517; CAAX amino protease 955963..956634 Streptococcus pneumoniae Hungary19A-6 6029431 YP_001694379.1 CDS SPH_1035 NC_010380.1 956686 956883 R hypothetical protein complement(956686..956883) Streptococcus pneumoniae Hungary19A-6 6028654 YP_001694380.1 CDS SPH_1036 NC_010380.1 956876 957784 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; regulatory function on capsule expression in group B streptococci 956876..957784 Streptococcus pneumoniae Hungary19A-6 6029086 YP_001694381.1 CDS lspA NC_010380.1 957781 958242 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 957781..958242 Streptococcus pneumoniae Hungary19A-6 6028148 YP_001694382.1 CDS rluD NC_010380.1 958232 959119 D identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase D 958232..959119 Streptococcus pneumoniae Hungary19A-6 6028813 YP_001694383.1 CDS SPH_1039 NC_010380.1 959122 961017 D identified by match to protein family HMM PF00753; match to protein family HMM PF01473; choline binding protein E 959122..961017 Streptococcus pneumoniae Hungary19A-6 6030013 YP_001694384.1 CDS proB NC_010380.1 961118 962227 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 961118..962227 Streptococcus pneumoniae Hungary19A-6 6030083 YP_001694385.1 CDS proA NC_010380.1 962237 963499 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 962237..963499 Streptococcus pneumoniae Hungary19A-6 6029060 YP_001694386.1 CDS proC NC_010380.1 963503 964300 D identified by match to protein family HMM PF01210; match to protein family HMM PF03807; match to protein family HMM TIGR00112; pyrroline-5-carboxylate reductase 963503..964300 Streptococcus pneumoniae Hungary19A-6 6028389 YP_001694387.1 CDS tmk NC_010380.1 964520 965158 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 964520..965158 Streptococcus pneumoniae Hungary19A-6 6027734 YP_001694388.1 CDS SPH_1044 NC_010380.1 965155 966045 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 965155..966045 Streptococcus pneumoniae Hungary19A-6 6029827 YP_001694389.1 CDS SPH_1045 NC_010380.1 966085 966402 D in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 966085..966402 Streptococcus pneumoniae Hungary19A-6 6028276 YP_001694390.1 CDS SPH_1046 NC_010380.1 966405 967283 D identified by match to protein family HMM PF00590; match to protein family HMM TIGR00096; hypothetical protein 966405..967283 Streptococcus pneumoniae Hungary19A-6 6028996 YP_001694391.1 CDS trmFO NC_010380.1 967418 968752 D TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 967418..968752 Streptococcus pneumoniae Hungary19A-6 6028477 YP_001694392.1 CDS pyrH NC_010380.1 968836 969573 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 968836..969573 Streptococcus pneumoniae Hungary19A-6 6028302 YP_001694393.1 CDS frr NC_010380.1 969582 970139 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 969582..970139 Streptococcus pneumoniae Hungary19A-6 6029980 YP_001694394.1 CDS SPH_1050 NC_010380.1 970160 971053 D S1 RNA-binding domain-containing protein 970160..971053 Streptococcus pneumoniae Hungary19A-6 6029742 YP_001694395.1 CDS SPH_1051 NC_010380.1 971062 971277 D identified by match to protein family HMM PF06855; hypothetical protein 971062..971277 Streptococcus pneumoniae Hungary19A-6 6028799 YP_001694396.1 CDS SPH_1052 NC_010380.1 971363 972367 D identified by match to protein family HMM PF02562; PhoH family protein 971363..972367 Streptococcus pneumoniae Hungary19A-6 6028998 YP_001694397.1 CDS SPH_1053 NC_010380.1 972475 973044 D identified by match to protein family HMM PF00583; acetyltransferase 972475..973044 Streptococcus pneumoniae Hungary19A-6 6030066 YP_001694398.1 CDS SPH_1054 NC_010380.1 973112 973762 D identified by match to protein family HMM PF00633; match to protein family HMM TIGR00426; match to protein family HMM TIGR01259; competence protein 973112..973762 Streptococcus pneumoniae Hungary19A-6 6029719 YP_001694399.1 CDS SPH_1055 NC_010380.1 973746 975986 D identified by match to protein family HMM PF03772; match to protein family HMM TIGR00360; match to protein family HMM TIGR00361; DNA internalization-related competence protein ComEC/Rec2 973746..975986 Streptococcus pneumoniae Hungary19A-6 6028611 YP_001694400.1 CDS SPH_1056 NC_010380.1 976207 976353 D hypothetical protein 976207..976353 Streptococcus pneumoniae Hungary19A-6 6028535 YP_001694401.1 CDS SPH_1057 NC_010380.1 976385 976972 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 976385..976972 Streptococcus pneumoniae Hungary19A-6 6029683 YP_001694402.1 CDS SPH_1058 NC_010380.1 976976 978157 D hypothetical protein 976976..978157 Streptococcus pneumoniae Hungary19A-6 6028680 YP_001694403.1 CDS SPH_1059 NC_010380.1 978174 978308 R identified by glimmer; hypothetical protein complement(978174..978308) Streptococcus pneumoniae Hungary19A-6 6029968 YP_001694404.1 CDS infC NC_010380.1 978437 978994 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 978437..978994 Streptococcus pneumoniae Hungary19A-6 6028623 YP_001694405.1 CDS rpmI NC_010380.1 979027 979227 D identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001; 50S ribosomal protein L35 979027..979227 Streptococcus pneumoniae Hungary19A-6 6028401 YP_001694406.1 CDS rplT NC_010380.1 979279 979638 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 979279..979638 Streptococcus pneumoniae Hungary19A-6 6028208 YP_001694407.1 CDS SPH_1063 NC_010380.1 979696 980076 D identified by match to protein family HMM PF00903; lactoylglutathione lyase 979696..980076 Streptococcus pneumoniae Hungary19A-6 6029069 YP_001694408.1 CDS SPH_1064 NC_010380.1 980326 981126 D responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+); dihydroorotate dehydrogenase electron transfer subunit 980326..981126 Streptococcus pneumoniae Hungary19A-6 6028255 YP_001694409.1 CDS SPH_1065 NC_010380.1 981137 982075 D dihydroorotate oxidase b; dhodehase b; dhodase b; dhod b; catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 981137..982075 Streptococcus pneumoniae Hungary19A-6 6027861 YP_001694410.1 CDS SPH_1067 NC_010380.1 982174 984282 D identified by match to protein family HMM PF01473; match to protein family HMM PF01832; endo-beta-N-acetylglucosaminidase 982174..984282 Streptococcus pneumoniae Hungary19A-6 6029163 YP_001694411.1 CDS SPH_1066 NC_010380.1 984254 985999 R identified by match to protein family HMM PF05670; match to protein family HMM PF05833; fibronectin/fibrinogen binding protein complement(984254..985999) Streptococcus pneumoniae Hungary19A-6 6029420 YP_001694412.1 CDS SPH_1068 NC_010380.1 986104 986601 D identified by match to protein family HMM PF02130; match to protein family HMM TIGR00043; metalloprotease 986104..986601 Streptococcus pneumoniae Hungary19A-6 6029637 YP_001694413.1 CDS SPH_1069 NC_010380.1 986582 986977 D identified by match to protein family HMM PF01219; diacylglycerol kinase (dagk) (diglyceride kinase)(dgk) 986582..986977 Streptococcus pneumoniae Hungary19A-6 6027728 YP_001694414.1 CDS era NC_010380.1 986994 987893 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 986994..987893 Streptococcus pneumoniae Hungary19A-6 6027851 YP_001694415.1 CDS mutM NC_010380.1 987908 988765 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 987908..988765 Streptococcus pneumoniae Hungary19A-6 6027877 YP_001694416.1 CDS coaE NC_010380.1 988765 989370 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 988765..989370 Streptococcus pneumoniae Hungary19A-6 6029310 YP_001694417.1 CDS SPH_1073 NC_010380.1 989357 990556 D identified by match to protein family HMM PF07690; multidrug resistance protein MdtG 989357..990556 Streptococcus pneumoniae Hungary19A-6 6028194 YP_001694418.1 CDS rpmG NC_010380.1 990556 990705 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 990556..990705 Streptococcus pneumoniae Hungary19A-6 6028138 YP_001694419.1 CDS secG NC_010380.1 990745 990978 D identified by match to protein family HMM PF03840; match to protein family HMM TIGR00810; preprotein translocase subunit SecG 990745..990978 Streptococcus pneumoniae Hungary19A-6 6029048 YP_001694420.1 CDS rnr NC_010380.1 991080 993434 D identified by match to protein family HMM PF00575; match to protein family HMM PF00773; match to protein family HMM PF08206; match to protein family HMM TIGR00358; match to protein family HMM TIGR02063; ribonuclease R 991080..993434 Streptococcus pneumoniae Hungary19A-6 6027834 YP_001694421.1 CDS smpB NC_010380.1 993397 993864 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 993397..993864 Streptococcus pneumoniae Hungary19A-6 6028979 YP_001694422.1 CDS tehB NC_010380.1 993880 994740 D with TehA confers resistance to tellurite; tellurite resistance protein TehB 993880..994740 Streptococcus pneumoniae Hungary19A-6 6029540 YP_001694423.1 CDS SPH_1079 NC_010380.1 994813 995766 D identified by match to protein family HMM PF06054; competence protein 994813..995766 Streptococcus pneumoniae Hungary19A-6 6029149 YP_001694424.1 CDS pepF1 NC_010380.1 995785 997587 D identified by match to protein family HMM PF01432; match to protein family HMM PF08439; match to protein family HMM TIGR00181; oligoendopeptidase F 995785..997587 Streptococcus pneumoniae Hungary19A-6 6028701 YP_001694425.1 CDS SPH_1081 NC_010380.1 997589 998302 D identified by match to protein family HMM PF01596; match to protein family HMM PF08241; O-methyltransferase 997589..998302 Streptococcus pneumoniae Hungary19A-6 6028124 YP_001694426.1 CDS prsA NC_010380.1 998369 999310 D cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase PrsA 998369..999310 Streptococcus pneumoniae Hungary19A-6 6029703 YP_001694427.1 CDS SPH_1083 NC_010380.1 999429 999779 R identified by match to protein family HMM PF00665; integrase core subunit complement(999429..999779) Streptococcus pneumoniae Hungary19A-6 6028340 YP_001694428.1 CDS SPH_1084 NC_010380.1 999769 999903 R hypothetical protein complement(999769..999903) Streptococcus pneumoniae Hungary19A-6 6028811 YP_001694429.1 CDS SPH_1085 NC_010380.1 1000529 1001149 R identified by match to protein family HMM PF00300; phosphoglycerate mutase complement(1000529..1001149) Streptococcus pneumoniae Hungary19A-6 6029834 YP_001694430.1 CDS SPH_1086 NC_010380.1 1001149 1001631 R identified by match to protein family HMM PF04073; regulatory protein complement(1001149..1001631) Streptococcus pneumoniae Hungary19A-6 6028724 YP_001694431.1 CDS SPH_1087 NC_010380.1 1001631 1002473 R identified by match to protein family HMM PF04018; hypothetical protein complement(1001631..1002473) Streptococcus pneumoniae Hungary19A-6 6027933 YP_001694432.1 CDS SPH_1088 NC_010380.1 1002568 1003317 R identified by match to protein family HMM PF01183; lyzozyme M1 complement(1002568..1003317) Streptococcus pneumoniae Hungary19A-6 6029208 YP_001694433.1 CDS glmU NC_010380.1 1003512 1004891 D forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 1003512..1004891 Streptococcus pneumoniae Hungary19A-6 6028374 YP_001694434.1 CDS SPH_1090 NC_010380.1 1004901 1005446 D identified by match to protein family HMM PF00293; ADP-ribose pyrophosphatase 1004901..1005446 Streptococcus pneumoniae Hungary19A-6 6028422 YP_001694435.1 CDS SPH_1091 NC_010380.1 1005458 1005772 D hypothetical protein 1005458..1005772 Streptococcus pneumoniae Hungary19A-6 6028264 YP_001694436.1 CDS mtnN NC_010380.1 1005789 1006481 D enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 1005789..1006481 Streptococcus pneumoniae Hungary19A-6 6027811 YP_001694437.1 CDS SPH_1093 NC_010380.1 1006570 1007049 D identified by match to protein family HMM PF04394; hypothetical protein 1006570..1007049 Streptococcus pneumoniae Hungary19A-6 6029118 YP_001694438.1 CDS SPH_1094 NC_010380.1 1007147 1007737 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 1007147..1007737 Streptococcus pneumoniae Hungary19A-6 6029595 YP_001694439.1 CDS SPH_1095 NC_010380.1 1007746 1009509 D identified by match to protein family HMM PF03009; glycerophosphoryl diester phosphodiesterase 1007746..1009509 Streptococcus pneumoniae Hungary19A-6 6029539 YP_001694440.1 CDS SPH_1097 NC_010380.1 1010229 1010369 D hypothetical protein 1010229..1010369 Streptococcus pneumoniae Hungary19A-6 6030089 YP_001694441.1 CDS SPH_1098 NC_010380.1 1010530 1010730 D hypothetical protein 1010530..1010730 Streptococcus pneumoniae Hungary19A-6 6028459 YP_001694442.1 CDS SPH_1099 NC_010380.1 1010772 1011176 D hypothetical protein 1010772..1011176 Streptococcus pneumoniae Hungary19A-6 6029821 YP_001694443.1 CDS SPH_1100 NC_010380.1 1011407 1012114 D identified by match to protein family HMM PF02683; cytochrome c-type biogenesis protein 1011407..1012114 Streptococcus pneumoniae Hungary19A-6 6028046 YP_001694444.1 CDS SPH_1101 NC_010380.1 1012125 1012682 D identified by match to protein family HMM PF00578; match to protein family HMM PF08534; thioredoxin family protein 1012125..1012682 Streptococcus pneumoniae Hungary19A-6 6028831 YP_001694445.1 CDS SPH_1102 NC_010380.1 1013056 1014447 D identified by match to protein family HMM PF00324; amino acid permease 1013056..1014447 Streptococcus pneumoniae Hungary19A-6 6028050 YP_001694446.1 CDS SPH_1103 NC_010380.1 1014590 1015507 D identified by match to protein family HMM PF01297; zinc-binding lipoprotein AdcA 1014590..1015507 Streptococcus pneumoniae Hungary19A-6 6028485 YP_001694447.1 CDS SPH_1104 NC_010380.1 1015515 1018064 D identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein B 1015515..1018064 Streptococcus pneumoniae Hungary19A-6 6029187 YP_001694448.1 CDS SPH_1105 NC_010380.1 1018275 1021394 D identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein E 1018275..1021394 Streptococcus pneumoniae Hungary19A-6 6029029 YP_001694449.1 CDS SPH_1107 NC_010380.1 1022404 1022880 D identified by match to protein family HMM PF04270; pneumococcal histidine triad protein E 1022404..1022880 Streptococcus pneumoniae Hungary19A-6 6027698 YP_001694450.1 CDS SPH_1108 NC_010380.1 1023175 1023432 D identified by glimmer; hypothetical protein 1023175..1023432 Streptococcus pneumoniae Hungary19A-6 6029009 YP_001694451.1 CDS SPH_1109 NC_010380.1 1023383 1023793 D identified by glimmer; hypothetical protein 1023383..1023793 Streptococcus pneumoniae Hungary19A-6 6029857 YP_001694452.1 CDS pepT NC_010380.1 1023829 1025052 R catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T complement(1023829..1025052) Streptococcus pneumoniae Hungary19A-6 6028095 YP_001694453.1 CDS hemH NC_010380.1 1025207 1026301 D identified by match to protein family HMM PF00762; match to protein family HMM TIGR00109; ferrochelatase 1025207..1026301 Streptococcus pneumoniae Hungary19A-6 6028153 YP_001694454.1 CDS mscL NC_010380.1 1026343 1026720 R identified by match to protein family HMM PF01741; match to protein family HMM TIGR00220; large conductance mechanosensitive channel protein complement(1026343..1026720) Streptococcus pneumoniae Hungary19A-6 6027846 YP_001694455.1 CDS SPH_1113 NC_010380.1 1026802 1027233 R identified by match to protein family HMM PF04138; MesH protein complement(1026802..1027233) Streptococcus pneumoniae Hungary19A-6 6029890 YP_001694456.1 CDS SPH_1114 NC_010380.1 1027356 1027865 D identified by match to protein family HMM PF06177; citrulline cluster-linked gene 1027356..1027865 Streptococcus pneumoniae Hungary19A-6 6028921 YP_001694457.1 CDS SPH_1116 NC_010380.1 1028133 1028291 R identified by glimmer; hypothetical protein complement(1028133..1028291) Streptococcus pneumoniae Hungary19A-6 6028804 YP_001694458.1 CDS asd NC_010380.1 1028622 1029698 D catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 1028622..1029698 Streptococcus pneumoniae Hungary19A-6 6028762 YP_001694459.1 CDS dapA NC_010380.1 1029754 1030689 D catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 1029754..1030689 Streptococcus pneumoniae Hungary19A-6 6028176 YP_001694460.1 CDS trmE NC_010380.1 1030736 1032109 R in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE complement(1030736..1032109) Streptococcus pneumoniae Hungary19A-6 6029665 YP_001694461.1 CDS SPH_1120 NC_010380.1 1032246 1032428 R 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase complement(1032246..1032428) Streptococcus pneumoniae Hungary19A-6 6028450 YP_001694462.1 CDS tdk NC_010380.1 1032551 1033150 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1032551..1033150 Streptococcus pneumoniae Hungary19A-6 6028258 YP_001694463.1 CDS SPH_1122 NC_010380.1 1033140 1033619 D identified by match to protein family HMM PF00583; acetyltransferase 1033140..1033619 Streptococcus pneumoniae Hungary19A-6 6028906 YP_001694464.1 CDS prfA NC_010380.1 1033629 1034708 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1033629..1034708 Streptococcus pneumoniae Hungary19A-6 6027752 YP_001694465.1 CDS hemK NC_010380.1 1034708 1035547 D identified by match to protein family HMM PF05175; match to protein family HMM PF08241; match to protein family HMM PF08242; match to protein family HMM TIGR00536; match to protein family HMM TIGR03387; protein-(glutamine-N5) methyltransferase, release factor-specific 1034708..1035547 Streptococcus pneumoniae Hungary19A-6 6028323 YP_001694466.1 CDS SPH_1125 NC_010380.1 1035531 1036133 D identified by match to protein family HMM PF01300; match to protein family HMM TIGR00057; Sua5/YciO/YrdC/YwlC family protein 1035531..1036133 Streptococcus pneumoniae Hungary19A-6 6028076 YP_001694467.1 CDS SPH_1126 NC_010380.1 1036135 1036566 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family protein 1036135..1036566 Streptococcus pneumoniae Hungary19A-6 6027787 YP_001694468.1 CDS glyA NC_010380.1 1036628 1037884 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 1036628..1037884 Streptococcus pneumoniae Hungary19A-6 6029577 YP_001694469.1 CDS SPH_1128 NC_010380.1 1037892 1038866 D hypothetical protein 1037892..1038866 Streptococcus pneumoniae Hungary19A-6 6028586 YP_001694470.1 CDS SPH_1129 NC_010380.1 1038866 1039480 D pneumococcal vaccine antigen A 1038866..1039480 Streptococcus pneumoniae Hungary19A-6 6029092 YP_001694471.1 CDS SPH_1130 NC_010380.1 1039554 1040528 D identified by match to protein family HMM PF06207; hypothetical protein 1039554..1040528 Streptococcus pneumoniae Hungary19A-6 6029782 YP_001694472.1 CDS rumA NC_010380.1 1040602 1042233 D identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA 1040602..1042233 Streptococcus pneumoniae Hungary19A-6 6028620 YP_001694473.1 CDS SPH_1132 NC_010380.1 1042982 1043200 D hypothetical protein 1042982..1043200 Streptococcus pneumoniae Hungary19A-6 6030075 YP_001694474.1 CDS SPH_1133 NC_010380.1 1043204 1043473 D identified by glimmer; hypothetical protein 1043204..1043473 Streptococcus pneumoniae Hungary19A-6 6028466 YP_001694475.1 CDS SPH_1134 NC_010380.1 1043593 1044618 D identified by match to protein family HMM PF01497; ABC transporter substrate-binding protein - iron transport 1043593..1044618 Streptococcus pneumoniae Hungary19A-6 6028638 YP_001694476.1 CDS SPH_1135 NC_010380.1 1044608 1045615 D identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 1044608..1045615 Streptococcus pneumoniae Hungary19A-6 6028592 YP_001694477.1 CDS SPH_1136 NC_010380.1 1045615 1046622 D identified by match to protein family HMM PF01032; ABC transporter membrane-spanning permease - iron transport 1045615..1046622 Streptococcus pneumoniae Hungary19A-6 6027867 YP_001694478.1 CDS SPH_1137 NC_010380.1 1046622 1047416 D identified by match to protein family HMM PF00005; ferric enterobactin transport ATP-binding protein FepC 1046622..1047416 Streptococcus pneumoniae Hungary19A-6 6027770 YP_001694479.1 CDS SPH_1138 NC_010380.1 1047984 1048193 D identified by match to protein family HMM PF07674; hypothetical protein 1047984..1048193 Streptococcus pneumoniae Hungary19A-6 6027797 YP_001694480.1 CDS SPH_1139 NC_010380.1 1048354 1048485 D hypothetical protein 1048354..1048485 Streptococcus pneumoniae Hungary19A-6 6028942 YP_001694481.1 CDS SPH_1140 NC_010380.1 1049169 1049330 D hypothetical protein 1049169..1049330 Streptococcus pneumoniae Hungary19A-6 6027925 YP_001694482.1 CDS SPH_1141 NC_010380.1 1049422 1051101 D identified by match to protein family HMM PF00239; match to protein family HMM PF07508; hypothetical protein 1049422..1051101 Streptococcus pneumoniae Hungary19A-6 6027918 YP_001694483.1 CDS SPH_1142 NC_010380.1 1051369 1051935 D hypothetical protein 1051369..1051935 Streptococcus pneumoniae Hungary19A-6 6029121 YP_001694484.1 CDS SPH_1143 NC_010380.1 1052257 1052445 D hypothetical protein 1052257..1052445 Streptococcus pneumoniae Hungary19A-6 6028177 YP_001694485.1 CDS SPH_1144 NC_010380.1 1052507 1053265 D identified by glimmer; hypothetical protein 1052507..1053265 Streptococcus pneumoniae Hungary19A-6 6028618 YP_001694486.1 CDS SPH_1145 NC_010380.1 1053323 1054177 D identified by match to protein family HMM PF03747; ADP-ribosylation/crystallin J1 1053323..1054177 Streptococcus pneumoniae Hungary19A-6 6028042 YP_001694487.1 CDS SPH_1146 NC_010380.1 1054289 1055173 D identified by match to protein family HMM PF00781; match to protein family HMM TIGR00147; hypothetical protein 1054289..1055173 Streptococcus pneumoniae Hungary19A-6 6029008 YP_001694488.1 CDS SPH_1147 NC_010380.1 1055336 1057075 D identified by match to protein family HMM PF00128; match to protein family HMM PF02903; neopullulanase 1055336..1057075 Streptococcus pneumoniae Hungary19A-6 6029221 YP_001694489.1 CDS SPH_1148 NC_010380.1 1057350 1057652 D identified by glimmer; hypothetical protein 1057350..1057652 Streptococcus pneumoniae Hungary19A-6 6029739 YP_001694490.1 CDS SPH_1149 NC_010380.1 1057708 1058136 D identified by match to protein family HMM PF00583; aminoglycoside 6'-N-acetyltransferase 1057708..1058136 Streptococcus pneumoniae Hungary19A-6 6028061 YP_001694491.1 CDS SPH_1150 NC_010380.1 1058233 1058490 D identified by glimmer; hypothetical protein 1058233..1058490 Streptococcus pneumoniae Hungary19A-6 6029972 YP_001694492.1 CDS SPH_1151 NC_010380.1 1058519 1058803 D ABC transporter ATP-binding protein 1058519..1058803 Streptococcus pneumoniae Hungary19A-6 6028271 YP_001694493.1 CDS SPH_1154 NC_010380.1 1059896 1061125 D identified by match to protein family HMM PF01098; cell division protein FtsW 1059896..1061125 Streptococcus pneumoniae Hungary19A-6 6028760 YP_001694494.1 CDS ppc NC_010380.1 1061145 1063841 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 1061145..1063841 Streptococcus pneumoniae Hungary19A-6 6027905 YP_001694495.1 CDS SPH_1157 NC_010380.1 1064254 1065258 D identified by match to protein family HMM PF04392; ABC transporter substrate binding protein 1064254..1065258 Streptococcus pneumoniae Hungary19A-6 6028005 YP_001694496.1 CDS SPH_1159 NC_010380.1 1065327 1066193 D identified by match to protein family HMM PF02653; ABC transporter ATP-binding protein 1065327..1066193 Streptococcus pneumoniae Hungary19A-6 6028144 YP_001694497.1 CDS dnaG NC_010380.1 1067038 1068798 D synthesizes RNA primers at the replication forks; DNA primase 1067038..1068798 Streptococcus pneumoniae Hungary19A-6 6029895 YP_001694498.1 CDS SPH_1161 NC_010380.1 1068801 1069910 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 1068801..1069910 Streptococcus pneumoniae Hungary19A-6 6028955 YP_001694499.1 CDS SPH_1162 NC_010380.1 1069924 1070253 D identified by match to protein family HMM PF01883; N-6 adenine-specific DNA methylase 1069924..1070253 Streptococcus pneumoniae Hungary19A-6 6028018 YP_001694500.1 CDS SPH_1163 NC_010380.1 1070368 1071411 D identified by match to protein family HMM PF00534; glycosyl transferase CpoA 1070368..1071411 Streptococcus pneumoniae Hungary19A-6 6029284 YP_001694501.1 CDS SPH_1164 NC_010380.1 1071427 1072752 D identified by match to protein family HMM PF00534; glycosyl transferase, group 1 1071427..1072752 Streptococcus pneumoniae Hungary19A-6 6027963 YP_001694502.1 CDS SPH_1165 NC_010380.1 1072766 1072957 D identified by match to protein family HMM PF04024; hypothetical protein 1072766..1072957 Streptococcus pneumoniae Hungary19A-6 6028929 YP_001694503.1 CDS SPH_1166 NC_010380.1 1073016 1073150 D hypothetical protein 1073016..1073150 Streptococcus pneumoniae Hungary19A-6 6028562 YP_001694504.1 CDS obgE NC_010380.1 1073220 1074524 D essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1073220..1074524 Streptococcus pneumoniae Hungary19A-6 6029797 YP_001694505.1 CDS SPH_1168 NC_010380.1 1074534 1074692 D hypothetical protein 1074534..1074692 Streptococcus pneumoniae Hungary19A-6 6028851 YP_001694506.1 CDS SPH_1171 NC_010380.1 1076412 1076537 D identified by glimmer; hypothetical protein 1076412..1076537 Streptococcus pneumoniae Hungary19A-6 6029548 YP_001694507.1 CDS SPH_1172 NC_010380.1 1076905 1077030 R identified by glimmer; hypothetical protein complement(1076905..1077030) Streptococcus pneumoniae Hungary19A-6 6029839 YP_001694508.1 CDS murA1 NC_010380.1 1077173 1078432 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1077173..1078432 Streptococcus pneumoniae Hungary19A-6 6028603 YP_001694509.1 CDS SPH_1174 NC_010380.1 1078448 1078999 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family protein 1078448..1078999 Streptococcus pneumoniae Hungary19A-6 6029167 YP_001694510.1 CDS SPH_1175 NC_010380.1 1078992 1080269 D identified by match to protein family HMM PF00571; match to protein family HMM PF07085; match to protein family HMM PF08279; CBS domain-containing cytosolic protein 1078992..1080269 Streptococcus pneumoniae Hungary19A-6 6028914 YP_001694511.1 CDS map NC_010380.1 1080285 1081145 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 1080285..1081145 Streptococcus pneumoniae Hungary19A-6 6029554 YP_001694512.1 CDS pcrA NC_010380.1 1082521 1084812 D identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073; ATP-dependent DNA helicase PcrA 1082521..1084812 Streptococcus pneumoniae Hungary19A-6 6028220 YP_001694513.1 CDS radC NC_010380.1 1084855 1085535 D Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 1084855..1085535 Streptococcus pneumoniae Hungary19A-6 6028826 YP_001694514.1 CDS SPH_1180 NC_010380.1 1085532 1086221 R identified by match to protein family HMM PF00117; match to protein family HMM PF07722; glutamine amidotransferase, class I complement(1085532..1086221) Streptococcus pneumoniae Hungary19A-6 6029645 YP_001694515.1 CDS SPH_1182 NC_010380.1 1086239 1086880 R modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex complement(1086239..1086880) Streptococcus pneumoniae Hungary19A-6 6029090 YP_001694516.1 CDS SPH_1183 NC_010380.1 1086963 1087106 R hypothetical protein complement(1086963..1087106) Streptococcus pneumoniae Hungary19A-6 6027723 YP_001694517.1 CDS SPH_1184 NC_010380.1 1087186 1087533 R identified by match to protein family HMM PF08866; hypothetical protein complement(1087186..1087533) Streptococcus pneumoniae Hungary19A-6 6028424 YP_001694518.1 CDS SPH_1185 NC_010380.1 1087538 1088653 R identified by match to protein family HMM PF00266; cysteine desulfurase complement(1087538..1088653) Streptococcus pneumoniae Hungary19A-6 6029859 YP_001694519.1 CDS SPH_1186 NC_010380.1 1088663 1089622 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1088663..1089622) Streptococcus pneumoniae Hungary19A-6 6029580 YP_001694520.1 CDS SPH_1187 NC_010380.1 1089735 1090304 R identified by match to protein family HMM PF01928; adenylate cyclase complement(1089735..1090304) Streptococcus pneumoniae Hungary19A-6 6028140 YP_001694521.1 CDS SPH_1188 NC_010380.1 1090432 1091103 D identified by match to protein family HMM PF04607; GTP pyrophosphokinase 1090432..1091103 Streptococcus pneumoniae Hungary19A-6 6028084 YP_001694522.1 CDS ppnK NC_010380.1 1091087 1091905 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1091087..1091905 Streptococcus pneumoniae Hungary19A-6 6029497 YP_001694523.1 CDS SPH_1190 NC_010380.1 1091902 1092798 D identified by match to protein family HMM PF00849; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase D 1091902..1092798 Streptococcus pneumoniae Hungary19A-6 6027827 YP_001694524.1 CDS eutD NC_010380.1 1092842 1093816 D in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 1092842..1093816 Streptococcus pneumoniae Hungary19A-6 6029270 YP_001694525.1 CDS SPH_1195 NC_010380.1 1095585 1095884 R identified by match to protein family HMM PF02575; match to protein family HMM TIGR00103; hypothetical protein complement(1095585..1095884) Streptococcus pneumoniae Hungary19A-6 6029330 YP_001694526.1 CDS SPH_1196 NC_010380.1 1096286 1096984 D identified by match to protein family HMM PF06912; hypothetical protein 1096286..1096984 Streptococcus pneumoniae Hungary19A-6 6029300 YP_001694527.1 CDS rplU NC_010380.1 1097172 1097486 D identified by match to protein family HMM PF00829; match to protein family HMM TIGR00061; 50S ribosomal protein L21 1097172..1097486 Streptococcus pneumoniae Hungary19A-6 6028545 YP_001694528.1 CDS SPH_1198 NC_010380.1 1097502 1097846 D identified by match to protein family HMM PF04327; hypothetical protein 1097502..1097846 Streptococcus pneumoniae Hungary19A-6 6028198 YP_001694529.1 CDS rpmA NC_010380.1 1097863 1098156 D involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1097863..1098156 Streptococcus pneumoniae Hungary19A-6 6029989 YP_001694530.1 CDS SPH_1201 NC_010380.1 1098538 1098666 R hypothetical protein complement(1098538..1098666) Streptococcus pneumoniae Hungary19A-6 6028870 YP_001694531.1 CDS ribF NC_010380.1 1099004 1099921 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1099004..1099921 Streptococcus pneumoniae Hungary19A-6 6028855 YP_001694532.1 CDS SPH_1203 NC_010380.1 1100014 1100862 R identified by match to protein family HMM PF02588; hypothetical protein complement(1100014..1100862) Streptococcus pneumoniae Hungary19A-6 6029629 YP_001694533.1 CDS SPH_1204 NC_010380.1 1101004 1101843 D identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; hypothetical protein 1101004..1101843 Streptococcus pneumoniae Hungary19A-6 6028379 YP_001694534.1 CDS SPH_1205 NC_010380.1 1101950 1102225 D identified by match to protein family HMM PF00216; DNA-binding protein HU 1 (DNA-binding protein II) (HB) 1101950..1102225 Streptococcus pneumoniae Hungary19A-6 6029262 YP_001694535.1 CDS SPH_1207 NC_010380.1 1102651 1104552 D identified by match to protein family HMM PF00005; ABC transporter ATPase 1102651..1104552 Streptococcus pneumoniae Hungary19A-6 6029716 YP_001694536.1 CDS SPH_1208 NC_010380.1 1104555 1105418 D identified by match to protein family HMM TIGR01716; transcriptional regulator 1104555..1105418 Streptococcus pneumoniae Hungary19A-6 6030070 YP_001694537.1 CDS SPH_1209 NC_010380.1 1105498 1106676 D identified by match to protein family HMM PF07690; ABC transporter membrane-spanning permease - macrolide efflux 1105498..1106676 Streptococcus pneumoniae Hungary19A-6 6029171 YP_001694538.1 CDS ligA NC_010380.1 1106769 1108727 D this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1106769..1108727 Streptococcus pneumoniae Hungary19A-6 6029001 YP_001694539.1 CDS pulA NC_010380.1 1108839 1111118 D identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02104; pullulanase, type I 1108839..1111118 Streptococcus pneumoniae Hungary19A-6 6027971 YP_001694540.1 CDS SPH_1212 NC_010380.1 1111169 1111330 D hypothetical protein 1111169..1111330 Streptococcus pneumoniae Hungary19A-6 6028662 YP_001694541.1 CDS SPH_1213 NC_010380.1 1111663 1113087 D identified by match to protein family HMM PF00171; NADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1111663..1113087 Streptococcus pneumoniae Hungary19A-6 6027836 YP_001694542.1 CDS glgB NC_010380.1 1113570 1115498 D catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 1113570..1115498 Streptococcus pneumoniae Hungary19A-6 6029026 YP_001694543.1 CDS glgC NC_010380.1 1115488 1116630 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1115488..1116630 Streptococcus pneumoniae Hungary19A-6 6027816 YP_001694544.1 CDS glgD NC_010380.1 1116620 1117759 D identified by match to protein family HMM PF00483; match to protein family HMM TIGR02092; glucose-1-phosphate adenylyltransferase, GlgD subunit 1116620..1117759 Streptococcus pneumoniae Hungary19A-6 6029266 YP_001694545.1 CDS glgA NC_010380.1 1117756 1119189 D catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 1117756..1119189 Streptococcus pneumoniae Hungary19A-6 6028888 YP_001694546.1 CDS SPH_1221 NC_010380.1 1119902 1121017 D identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase 1119902..1121017 Streptococcus pneumoniae Hungary19A-6 6029099 YP_001694547.1 CDS SPH_1220 NC_010380.1 1121014 1121460 R identified by match to protein family HMM PF07997; hypothetical protein complement(1121014..1121460) Streptococcus pneumoniae Hungary19A-6 6028063 YP_001694548.1 CDS eno NC_010380.1 1121624 1122928 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1121624..1122928 Streptococcus pneumoniae Hungary19A-6 6029473 YP_001694549.1 CDS SPH_1223 NC_010380.1 1123066 1123446 R identified by match to protein family HMM PF00589; integrase/recombinase, phage integrase complement(1123066..1123446) Streptococcus pneumoniae Hungary19A-6 6027832 YP_001694550.1 CDS rexB NC_010380.1 1124783 1128058 D identified by match to protein family HMM TIGR02774; ATP-dependent nuclease subunit B 1124783..1128058 Streptococcus pneumoniae Hungary19A-6 6029409 YP_001694551.1 CDS addA NC_010380.1 1128055 1131705 D identified by match to protein family HMM PF00580; match to protein family HMM TIGR02785; recombination helicase AddA 1128055..1131705 Streptococcus pneumoniae Hungary19A-6 6029883 YP_001694552.1 CDS SPH_1227 NC_010380.1 1131716 1131907 D hypothetical protein 1131716..1131907 Streptococcus pneumoniae Hungary19A-6 6027689 YP_001694553.1 CDS SPH_1228 NC_010380.1 1131920 1132867 D identified by glimmer; hypothetical protein 1131920..1132867 Streptococcus pneumoniae Hungary19A-6 6029391 YP_001694554.1 CDS SPH_1229 NC_010380.1 1133305 1138983 D identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM PF07581; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; immunoglobulin A1 protease 1133305..1138983 Streptococcus pneumoniae Hungary19A-6 6027930 YP_001694555.1 CDS SPH_1230 NC_010380.1 1139217 1140473 R identified by match to protein family HMM PF01610; transposase complement(1139217..1140473) Streptococcus pneumoniae Hungary19A-6 6028703 YP_001694556.1 CDS SPH_1231 NC_010380.1 1141097 1141270 D hypothetical protein 1141097..1141270 Streptococcus pneumoniae Hungary19A-6 6028704 YP_001694557.1 CDS SPH_1232 NC_010380.1 1141267 1142046 D identified by match to protein family HMM PF06970; replication initiator protein A (RepA) N-terminus 1141267..1142046 Streptococcus pneumoniae Hungary19A-6 6029879 YP_001694558.1 CDS SPH_1233 NC_010380.1 1142145 1143503 D identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675; methyl transferase 1142145..1143503 Streptococcus pneumoniae Hungary19A-6 6029298 YP_001694559.1 CDS SPH_1234 NC_010380.1 1143487 1143936 D hypothetical protein 1143487..1143936 Streptococcus pneumoniae Hungary19A-6 6028639 YP_001694560.1 CDS SPH_1235 NC_010380.1 1143929 1144309 D hypothetical protein 1143929..1144309 Streptococcus pneumoniae Hungary19A-6 6028091 YP_001694561.1 CDS SPH_1236 NC_010380.1 1144322 1144555 D hypothetical protein 1144322..1144555 Streptococcus pneumoniae Hungary19A-6 6027792 YP_001694562.1 CDS SPH_1237 NC_010380.1 1144558 1145145 D identified by match to protein family HMM PF02517; CAAX amino protease 1144558..1145145 Streptococcus pneumoniae Hungary19A-6 6028339 YP_001694563.1 CDS SPH_1238 NC_010380.1 1145275 1145865 D hypothetical protein 1145275..1145865 Streptococcus pneumoniae Hungary19A-6 6027935 YP_001694564.1 CDS SPH_1239 NC_010380.1 1145865 1146701 D identified by match to protein family HMM PF08843; hypothetical protein 1145865..1146701 Streptococcus pneumoniae Hungary19A-6 6029170 YP_001694565.1 CDS SPH_1240 NC_010380.1 1146983 1147282 D hypothetical protein 1146983..1147282 Streptococcus pneumoniae Hungary19A-6 6029503 YP_001694566.1 CDS SPH_1241 NC_010380.1 1147272 1147760 D hypothetical protein 1147272..1147760 Streptococcus pneumoniae Hungary19A-6 6027998 YP_001694567.1 CDS SPH_1242 NC_010380.1 1147760 1149637 D identified by match to protein family HMM PF02534; TraG/TraD family protein 1147760..1149637 Streptococcus pneumoniae Hungary19A-6 6028711 YP_001694568.1 CDS SPH_1243 NC_010380.1 1149658 1149900 D hypothetical protein 1149658..1149900 Streptococcus pneumoniae Hungary19A-6 6029899 YP_001694569.1 CDS SPH_1244 NC_010380.1 1149917 1150771 D hypothetical protein 1149917..1150771 Streptococcus pneumoniae Hungary19A-6 6028190 YP_001694570.1 CDS SPH_1245 NC_010380.1 1150825 1151184 D hypothetical protein 1150825..1151184 Streptococcus pneumoniae Hungary19A-6 6029124 YP_001694571.1 CDS SPH_1246 NC_010380.1 1151177 1153492 D hypothetical protein 1151177..1153492 Streptococcus pneumoniae Hungary19A-6 6030023 YP_001694572.1 CDS SPH_1247 NC_010380.1 1153504 1156317 D identified by match to protein family HMM PF01551; match to protein family HMM PF05257; M23 peptidase domain-containing protein 1153504..1156317 Streptococcus pneumoniae Hungary19A-6 6028359 YP_001694573.1 CDS SPH_1248 NC_010380.1 1156555 1157130 D hypothetical protein 1156555..1157130 Streptococcus pneumoniae Hungary19A-6 6029546 YP_001694574.1 CDS SPH_1249 NC_010380.1 1157282 1157692 D Ig domain-containing protein 1157282..1157692 Streptococcus pneumoniae Hungary19A-6 6028315 YP_001694575.1 CDS SPH_1252 NC_010380.1 1164038 1164322 D hypothetical protein 1164038..1164322 Streptococcus pneumoniae Hungary19A-6 6028288 YP_001694576.1 CDS SPH_1253 NC_010380.1 1164336 1164656 D hypothetical protein 1164336..1164656 Streptococcus pneumoniae Hungary19A-6 6028569 YP_001694577.1 CDS SPH_1254 NC_010380.1 1165386 1166423 D identified by glimmer; hypothetical protein 1165386..1166423 Streptococcus pneumoniae Hungary19A-6 6029441 YP_001694578.1 CDS SPH_1255 NC_010380.1 1166468 1166866 D identified by glimmer; hypothetical protein 1166468..1166866 Streptococcus pneumoniae Hungary19A-6 6029172 YP_001694579.1 CDS SPH_1256 NC_010380.1 1167194 1168075 D hypothetical protein 1167194..1168075 Streptococcus pneumoniae Hungary19A-6 6029550 YP_001694580.1 CDS SPH_1257 NC_010380.1 1168479 1169120 D hypothetical protein 1168479..1169120 Streptococcus pneumoniae Hungary19A-6 6029752 YP_001694581.1 CDS SPH_1258 NC_010380.1 1169130 1170215 D DNA primase 1169130..1170215 Streptococcus pneumoniae Hungary19A-6 6030009 YP_001694582.1 CDS SPH_1259 NC_010380.1 1170266 1170499 D hypothetical protein 1170266..1170499 Streptococcus pneumoniae Hungary19A-6 6027966 YP_001694583.1 CDS SPH_1260 NC_010380.1 1170496 1170879 D methyl-accepting chemotaxis protein 1170496..1170879 Streptococcus pneumoniae Hungary19A-6 6028295 YP_001694584.1 CDS SPH_1261 NC_010380.1 1170917 1171189 D ATPases with chaperone activity, ATP-binding subunit 1170917..1171189 Streptococcus pneumoniae Hungary19A-6 6028590 YP_001694585.1 CDS SPH_1262 NC_010380.1 1171455 1171736 D hypothetical protein 1171455..1171736 Streptococcus pneumoniae Hungary19A-6 6028578 YP_001694586.1 CDS SPH_1263 NC_010380.1 1171736 1172494 D identified by match to protein family HMM PF06414; signal recognition particle GTPase 1171736..1172494 Streptococcus pneumoniae Hungary19A-6 6028128 YP_001694587.1 CDS SPH_1264 NC_010380.1 1172970 1173758 D identified by glimmer; hypothetical protein 1172970..1173758 Streptococcus pneumoniae Hungary19A-6 6028406 YP_001694588.1 CDS SPH_1265 NC_010380.1 1173997 1174245 D identified by glimmer; hypothetical protein 1173997..1174245 Streptococcus pneumoniae Hungary19A-6 6029328 YP_001694589.1 CDS SPH_1266 NC_010380.1 1174416 1175066 D identified by match to protein family HMM PF00302; chloramphenicol O-acetyltransferase 1174416..1175066 Streptococcus pneumoniae Hungary19A-6 6028337 YP_001694590.1 CDS SPH_1267 NC_010380.1 1175931 1176854 R identified by match to protein family HMM PF01446; replication protein complement(1175931..1176854) Streptococcus pneumoniae Hungary19A-6 6028656 YP_001694591.1 CDS SPH_1269 NC_010380.1 1177117 1177608 D N-(5'-phosphoribosyl)anthranilate isomerase 1177117..1177608 Streptococcus pneumoniae Hungary19A-6 6029470 YP_001694592.1 CDS SPH_1270 NC_010380.1 1177785 1179527 D identified by match to protein family HMM PF00128; match to protein family HMM PF02903; neopullulanase 1177785..1179527 Streptococcus pneumoniae Hungary19A-6 6028814 YP_001694593.1 CDS SPH_1271 NC_010380.1 1179647 1179958 D hypothetical protein 1179647..1179958 Streptococcus pneumoniae Hungary19A-6 6030019 YP_001694594.1 CDS SPH_1272 NC_010380.1 1179962 1180696 D hypothetical protein 1179962..1180696 Streptococcus pneumoniae Hungary19A-6 6028957 YP_001694595.1 CDS rbgA NC_010380.1 1181025 1181876 D essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1181025..1181876 Streptococcus pneumoniae Hungary19A-6 6028867 YP_001694596.1 CDS rnhB NC_010380.1 1181863 1182642 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1181863..1182642 Streptococcus pneumoniae Hungary19A-6 6030036 YP_001694597.1 CDS SPH_1275 NC_010380.1 1182658 1184208 D identified by match to protein family HMM PF00654; match to protein family HMM PF02080; voltage-gated chloride channel family protein 1182658..1184208 Streptococcus pneumoniae Hungary19A-6 6027917 YP_001694598.1 CDS xerS NC_010380.1 1184794 1185864 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1184794..1185864 Streptococcus pneumoniae Hungary19A-6 6029919 YP_001694599.1 CDS SPH_1278 NC_010380.1 1185959 1186492 D identified by match to protein family HMM PF01527; transposase 1185959..1186492 Streptococcus pneumoniae Hungary19A-6 6028980 YP_001694600.1 CDS SPH_1279 NC_010380.1 1186654 1187322 D identified by match to protein family HMM PF00665; integrase core subunit 1186654..1187322 Streptococcus pneumoniae Hungary19A-6 6029717 YP_001694601.1 CDS SPH_1280 NC_010380.1 1187504 1188856 R identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; mate efflux family protein complement(1187504..1188856) Streptococcus pneumoniae Hungary19A-6 6029788 YP_001694602.1 CDS pyrC NC_010380.1 1189141 1190409 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1189141..1190409) Streptococcus pneumoniae Hungary19A-6 6029299 YP_001694603.1 CDS SPH_1282 NC_010380.1 1190422 1190886 R 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase; identified by match to protein family HMM PF00293; mutator MutT protein complement(1190422..1190886) Streptococcus pneumoniae Hungary19A-6 6028213 YP_001694604.1 CDS ung NC_010380.1 1190896 1191549 R Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase complement(1190896..1191549) Streptococcus pneumoniae Hungary19A-6 6027941 YP_001694605.1 CDS SPH_1284 NC_010380.1 1191611 1192303 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; match to protein family HMM TIGR02254; HAD family hydrolase complement(1191611..1192303) Streptococcus pneumoniae Hungary19A-6 6029885 YP_001694606.1 CDS SPH_1285 NC_010380.1 1192428 1192646 R identified by glimmer; hypothetical protein complement(1192428..1192646) Streptococcus pneumoniae Hungary19A-6 6028243 YP_001694607.1 CDS SPH_1286 NC_010380.1 1192997 1194679 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC-type multidrug/protein/lipid transport system, ATPase component complement(1192997..1194679) Streptococcus pneumoniae Hungary19A-6 6030033 YP_001694608.1 CDS SPH_1287 NC_010380.1 1194701 1195420 R identified by match to protein family HMM PF00005; bacitracin transport ATP-binding protein BcrA complement(1194701..1195420) Streptococcus pneumoniae Hungary19A-6 6029856 YP_001694609.1 CDS SPH_1288 NC_010380.1 1195555 1196295 R hypothetical protein complement(1195555..1196295) Streptococcus pneumoniae Hungary19A-6 6028480 YP_001694610.1 CDS SPH_1289 NC_010380.1 1196467 1197102 R identified by match to protein family HMM PF00440; transcriptional regulator, TetR family protein complement(1196467..1197102) Streptococcus pneumoniae Hungary19A-6 6029053 YP_001694611.1 CDS SPH_1290 NC_010380.1 1197684 1198058 R identified by match to protein family HMM PF03610; match to protein family HMM TIGR02364; phosphotransferase mannnose-specific family component IIA complement(1197684..1198058) Streptococcus pneumoniae Hungary19A-6 6029361 YP_001694612.1 CDS SPH_1291 NC_010380.1 1198058 1198633 R identified by match to protein family HMM PF02734; match to protein family HMM TIGR02365; dihydroxyacetone kinase, L subunit complement(1198058..1198633) Streptococcus pneumoniae Hungary19A-6 6029342 YP_001694613.1 CDS dhaK1 NC_010380.1 1198655 1199644 R with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK complement(1198655..1199644) Streptococcus pneumoniae Hungary19A-6 6028757 YP_001694614.1 CDS SPH_1293 NC_010380.1 1199771 1200328 D identified by match to protein family HMM TIGR02366; dihydroxyacetone kinase regulator 1199771..1200328 Streptococcus pneumoniae Hungary19A-6 6029356 YP_001694615.1 CDS dhaK2 NC_010380.1 1200325 1201314 D similar to DhaK; in Lactococcus lactis this protein froms a stable complex with DhaS and activates transcription of the dha operon in the presence of dihydroxyacetone; DhaKLM operon coactivator DhaQ 1200325..1201314 Streptococcus pneumoniae Hungary19A-6 6028676 YP_001694616.1 CDS SPH_1295 NC_010380.1 1201412 1201951 R identified by match to protein family HMM PF08020; hypothetical protein complement(1201412..1201951) Streptococcus pneumoniae Hungary19A-6 6029842 YP_001694617.1 CDS SPH_1296 NC_010380.1 1202009 1202503 R identified by match to protein family HMM PF03692; hypothetical protein complement(1202009..1202503) Streptococcus pneumoniae Hungary19A-6 6030031 YP_001694618.1 CDS ptsP NC_010380.1 1202637 1204361 R identified by match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR01417; phosphoenolpyruvate-protein phosphotransferase complement(1202637..1204361) Streptococcus pneumoniae Hungary19A-6 6028281 YP_001694619.1 CDS SPH_1298 NC_010380.1 1204376 1204639 R identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; phosphocarrier protein HPr complement(1204376..1204639) Streptococcus pneumoniae Hungary19A-6 6028397 YP_001694620.1 CDS SPH_1299 NC_010380.1 1204989 1205207 D identified by match to protein family HMM PF00462; match to protein family HMM TIGR02194; glutaredoxin 1204989..1205207 Streptococcus pneumoniae Hungary19A-6 6028628 YP_001694621.1 CDS SPH_1300 NC_010380.1 1205288 1207447 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1205288..1207447 Streptococcus pneumoniae Hungary19A-6 6028780 YP_001694622.1 CDS nrdF NC_010380.1 1207635 1208597 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1207635..1208597 Streptococcus pneumoniae Hungary19A-6 6029584 YP_001694623.1 CDS SPH_1302 NC_010380.1 1208779 1209540 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; lactose phosphotransferase system repressor 1208779..1209540 Streptococcus pneumoniae Hungary19A-6 6029828 YP_001694624.1 CDS SPH_1303 NC_010380.1 1209819 1210076 R hypothetical protein complement(1209819..1210076) Streptococcus pneumoniae Hungary19A-6 6029065 YP_001694625.1 CDS lacG2 NC_010380.1 1210119 1211525 R catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase complement(1210119..1211525) Streptococcus pneumoniae Hungary19A-6 6029520 YP_001694626.1 CDS SPH_1305 NC_010380.1 1211740 1213431 R identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00394; match to protein family HMM TIGR00410; match to protein family HMM TIGR00853; PTS system, lactose-specific IIC component complement(1211740..1213431) Streptococcus pneumoniae Hungary19A-6 6028742 YP_001694627.1 CDS SPH_1306 NC_010380.1 1213431 1213748 R pts system lactose-specific eiia component; eiia-lac; eiii-lac; identified by match to protein family HMM PF02255; match to protein family HMM TIGR00823; lactose-specific phosphotransferase enzyme IIA component complement(1213431..1213748) Streptococcus pneumoniae Hungary19A-6 6029351 YP_001694628.1 CDS SPH_1307 NC_010380.1 1213784 1214620 R identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator LacT complement(1213784..1214620) Streptococcus pneumoniae Hungary19A-6 6029377 YP_001694629.1 CDS lacD NC_010380.1 1214854 1215834 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase complement(1214854..1215834) Streptococcus pneumoniae Hungary19A-6 6029119 YP_001694630.1 CDS lacC NC_010380.1 1215836 1216765 R catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase complement(1215836..1216765) Streptococcus pneumoniae Hungary19A-6 6028693 YP_001694631.1 CDS lacB NC_010380.1 1216776 1217291 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB complement(1216776..1217291) Streptococcus pneumoniae Hungary19A-6 6028237 YP_001694632.1 CDS lacA NC_010380.1 1217322 1217747 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA complement(1217322..1217747) Streptococcus pneumoniae Hungary19A-6 6028658 YP_001694633.1 CDS SPH_1312 NC_010380.1 1217904 1218248 R identified by glimmer; hypothetical protein complement(1217904..1218248) Streptococcus pneumoniae Hungary19A-6 6029353 YP_001694634.1 CDS SPH_1313 NC_010380.1 1218417 1218806 R identified by match to protein family HMM PF01609; mobile genetic element complement(1218417..1218806) Streptococcus pneumoniae Hungary19A-6 6029433 YP_001694635.1 CDS SPH_1315 NC_010380.1 1219228 1219530 R PTS system, galactose-specific IIB component complement(1219228..1219530) Streptococcus pneumoniae Hungary19A-6 6029475 YP_001694636.1 CDS SPH_1317 NC_010380.1 1220224 1220421 D chlorohydrolase 1220224..1220421 Streptococcus pneumoniae Hungary19A-6 6029940 YP_001694637.1 CDS lepA NC_010380.1 1220502 1222325 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(1220502..1222325) Streptococcus pneumoniae Hungary19A-6 6028412 YP_001694638.1 CDS SPH_1319 NC_010380.1 1222404 1223132 R identified by match to protein family HMM PF00149; serine/threonine protein phosphatase complement(1222404..1223132) Streptococcus pneumoniae Hungary19A-6 6027701 YP_001694639.1 CDS recN NC_010380.1 1223134 1224801 R identified by match to protein family HMM PF02463; match to protein family HMM TIGR00634; DNA repair protein RecN complement(1223134..1224801) Streptococcus pneumoniae Hungary19A-6 6029533 YP_001694640.1 CDS SPH_1321 NC_010380.1 1224808 1225239 R identified by match to protein family HMM PF01316; match to protein family HMM PF02863; transcriptional regulator of arginine metabolism expression complement(1224808..1225239) Streptococcus pneumoniae Hungary19A-6 6029559 YP_001694641.1 CDS tylA NC_010380.1 1225232 1226047 R identified by match to protein family HMM PF01479; match to protein family HMM PF01728; match to protein family HMM TIGR00478; hemolysin A complement(1225232..1226047) Streptococcus pneumoniae Hungary19A-6 6028478 YP_001694642.1 CDS SPH_1323 NC_010380.1 1226040 1226915 R identified by match to protein family HMM PF00348; geranyltranstransferase (farnesyl-diphosphate synthase)(FPP synthase) complement(1226040..1226915) Streptococcus pneumoniae Hungary19A-6 6028117 YP_001694643.1 CDS xseB NC_010380.1 1226912 1227124 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(1226912..1227124) Streptococcus pneumoniae Hungary19A-6 6029117 YP_001694644.1 CDS xseA NC_010380.1 1227102 1228442 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(1227102..1228442) Streptococcus pneumoniae Hungary19A-6 6027958 YP_001694645.1 CDS udk NC_010380.1 1228570 1229208 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(1228570..1229208) Streptococcus pneumoniae Hungary19A-6 6029476 YP_001694646.1 CDS SPH_1327 NC_010380.1 1229316 1229618 R hypothetical protein complement(1229316..1229618) Streptococcus pneumoniae Hungary19A-6 6028490 YP_001694647.1 CDS truB NC_010380.1 1229859 1230737 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(1229859..1230737) Streptococcus pneumoniae Hungary19A-6 6028307 YP_001694648.1 CDS SPH_1329 NC_010380.1 1230747 1232021 R hypothetical protein complement(1230747..1232021) Streptococcus pneumoniae Hungary19A-6 6029880 YP_001694649.1 CDS SPH_1332 NC_010380.1 1233524 1234321 R identified by match to protein family HMM PF01226; formate-nitrate transporter complement(1233524..1234321) Streptococcus pneumoniae Hungary19A-6 6028250 YP_001694650.1 CDS SPH_1333 NC_010380.1 1234565 1235308 R identified by match to protein family HMM PF04203; match to protein family HMM TIGR01076; sortase complement(1234565..1235308) Streptococcus pneumoniae Hungary19A-6 6028650 YP_001694651.1 CDS gyrA NC_010380.1 1235308 1237776 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(1235308..1237776) Streptococcus pneumoniae Hungary19A-6 6028182 YP_001694652.1 CDS ldh NC_010380.1 1237970 1238956 D Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1237970..1238956 Streptococcus pneumoniae Hungary19A-6 6027702 YP_001694653.1 CDS SPH_1336 NC_010380.1 1239204 1239977 R identified by match to protein family HMM PF00520; match to protein family HMM PF07885; potassium/ion channel protein complement(1239204..1239977) Streptococcus pneumoniae Hungary19A-6 6028015 YP_001694654.1 CDS SPH_1337 NC_010380.1 1240024 1240278 R identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; cytotoxic translational repressor of toxin-antitoxin stability system complement(1240024..1240278) Streptococcus pneumoniae Hungary19A-6 6029756 YP_001694655.1 CDS SPH_1338 NC_010380.1 1240280 1240522 R hypothetical protein complement(1240280..1240522) Streptococcus pneumoniae Hungary19A-6 6028905 YP_001694656.1 CDS SPH_1339 NC_010380.1 1240613 1241422 R identified by match to protein family HMM PF00753; VicX protein complement(1240613..1241422) Streptococcus pneumoniae Hungary19A-6 6028540 YP_001694657.1 CDS SPH_1340 NC_010380.1 1241424 1242773 R identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM TIGR00229; sensor protein YycG complement(1241424..1242773) Streptococcus pneumoniae Hungary19A-6 6028502 YP_001694658.1 CDS SPH_1341 NC_010380.1 1242766 1243470 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; alkaline phosphatase synthesis transcriptional regulatory protein PhoP complement(1242766..1243470) Streptococcus pneumoniae Hungary19A-6 6029317 YP_001694659.1 CDS mutY NC_010380.1 1243525 1244700 R identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01084; A/G-specific adenine glycosylase complement(1243525..1244700) Streptococcus pneumoniae Hungary19A-6 6029958 YP_001694660.1 CDS SPH_1343 NC_010380.1 1244784 1245017 R identified by glimmer; hypothetical protein complement(1244784..1245017) Streptococcus pneumoniae Hungary19A-6 6028974 YP_001694661.1 CDS fhs NC_010380.1 1245028 1246698 R catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase complement(1245028..1246698) Streptococcus pneumoniae Hungary19A-6 6029509 YP_001694662.1 CDS coaB NC_010380.1 1246928 1247617 D identified by match to protein family HMM PF04127; match to protein family HMM TIGR02114; phosphopantothenate--cysteine ligase 1246928..1247617 Streptococcus pneumoniae Hungary19A-6 6029052 YP_001694663.1 CDS coaC NC_010380.1 1247629 1248180 D decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 1247629..1248180 Streptococcus pneumoniae Hungary19A-6 6029600 YP_001694664.1 CDS SPH_1347 NC_010380.1 1248164 1248727 D hypothetical protein 1248164..1248727 Streptococcus pneumoniae Hungary19A-6 6029685 YP_001694665.1 CDS SPH_1348 NC_010380.1 1248991 1249518 D hypothetical protein 1248991..1249518 Streptococcus pneumoniae Hungary19A-6 6028788 YP_001694666.1 CDS SPH_1350 NC_010380.1 1249530 1250045 D identified by match to protein family HMM PF02829; match to protein family HMM PF08279; biotin repressor family transcriptional regulator 1249530..1250045 Streptococcus pneumoniae Hungary19A-6 6028637 YP_001694667.1 CDS SPH_1349 NC_010380.1 1250042 1250509 R similart to NTP pyrophosphohydrolase including oxidative damage repair enzymes; identified by match to protein family HMM PF00293; NTP pyrophosphohydrolase complement(1250042..1250509) Streptococcus pneumoniae Hungary19A-6 6028114 YP_001694668.1 CDS SPH_1351 NC_010380.1 1250583 1251071 R identified by match to protein family HMM PF00583; acetyltransferase complement(1250583..1251071) Streptococcus pneumoniae Hungary19A-6 6028431 YP_001694669.1 CDS SPH_1352 NC_010380.1 1251037 1251600 R acetyltransferase complement(1251037..1251600) Streptococcus pneumoniae Hungary19A-6 6029991 YP_001694670.1 CDS uvrB NC_010380.1 1251610 1253598 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B complement(1251610..1253598) Streptococcus pneumoniae Hungary19A-6 6029760 YP_001694671.1 CDS SPH_1356 NC_010380.1 1254799 1256964 D identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter amino acid-binding protein/permease 1254799..1256964 Streptococcus pneumoniae Hungary19A-6 6028728 YP_001694672.1 CDS SPH_1357 NC_010380.1 1256964 1257704 D identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 1256964..1257704 Streptococcus pneumoniae Hungary19A-6 6029597 YP_001694673.1 CDS zwf NC_010380.1 1257853 1259340 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1257853..1259340 Streptococcus pneumoniae Hungary19A-6 6027937 YP_001694674.1 CDS SPH_1359 NC_010380.1 1259386 1260663 R identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM TIGR00064; cell division protein FtsY complement(1259386..1260663) Streptococcus pneumoniae Hungary19A-6 6027720 YP_001694675.1 CDS SPH_1360 NC_010380.1 1260667 1261485 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1260667..1261485) Streptococcus pneumoniae Hungary19A-6 6028878 YP_001694676.1 CDS SPH_1361 NC_010380.1 1261485 1262279 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1261485..1262279) Streptococcus pneumoniae Hungary19A-6 6027876 YP_001694677.1 CDS smc NC_010380.1 1262276 1265815 R identified by match to protein family HMM PF02463; match to protein family HMM PF06470; match to protein family HMM TIGR02168; chromosome segregation protein SMC complement(1262276..1265815) Streptococcus pneumoniae Hungary19A-6 6028001 YP_001694678.1 CDS rnc NC_010380.1 1265806 1266504 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(1265806..1266504) Streptococcus pneumoniae Hungary19A-6 6029746 YP_001694679.1 CDS guaC NC_010380.1 1266822 1267808 R identified by match to protein family HMM PF00478; match to protein family HMM TIGR01306; guanosine 5'-monophosphate oxidoreductase complement(1266822..1267808) Streptococcus pneumoniae Hungary19A-6 6028436 YP_001694680.1 CDS SPH_1366 NC_010380.1 1267911 1269299 R hypothetical protein complement(1267911..1269299) Streptococcus pneumoniae Hungary19A-6 6027844 YP_001694681.1 CDS SPH_1367 NC_010380.1 1269286 1271217 R hypothetical protein complement(1269286..1271217) Streptococcus pneumoniae Hungary19A-6 6029153 YP_001694682.1 CDS SPH_1371 NC_010380.1 1272168 1272527 R isopropylmalate isomerase; alpha-ipm isomerase; ipmi; hypothetical protein complement(1272168..1272527) Streptococcus pneumoniae Hungary19A-6 6029471 YP_001694683.1 CDS SPH_1372 NC_010380.1 1272531 1272800 R identified by match to protein family HMM PF06961; hypothetical protein complement(1272531..1272800) Streptococcus pneumoniae Hungary19A-6 6029136 YP_001694684.1 CDS leuB NC_010380.1 1272797 1273834 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(1272797..1273834) Streptococcus pneumoniae Hungary19A-6 6029286 YP_001694685.1 CDS SPH_1374 NC_010380.1 1273846 1274940 R identified by match to protein family HMM PF00682; match to protein family HMM PF08502; 2-isopropylmalate synthase complement(1273846..1274940) Streptococcus pneumoniae Hungary19A-6 6028678 YP_001694686.1 CDS SPH_1375 NC_010380.1 1274959 1275615 R identified by match to protein family HMM PF04237; hypothetical protein complement(1274959..1275615) Streptococcus pneumoniae Hungary19A-6 6028977 YP_001694687.1 CDS SPH_1376 NC_010380.1 1275659 1276291 R identified by match to protein family HMM PF03932; copper homeostasis protein CutC complement(1275659..1276291) Streptococcus pneumoniae Hungary19A-6 6028330 YP_001694688.1 CDS SPH_1377 NC_010380.1 1276384 1276743 R identified by match to protein family HMM PF04304; hypothetical protein complement(1276384..1276743) Streptococcus pneumoniae Hungary19A-6 6028410 YP_001694689.1 CDS topA NC_010380.1 1276849 1278936 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(1276849..1278936) Streptococcus pneumoniae Hungary19A-6 6028000 YP_001694690.1 CDS SPH_1379 NC_010380.1 1279103 1279309 R identified by glimmer; hypothetical protein complement(1279103..1279309) Streptococcus pneumoniae Hungary19A-6 6028449 YP_001694691.1 CDS SPH_1381 NC_010380.1 1280223 1280342 R identified by glimmer; hypothetical protein complement(1280223..1280342) Streptococcus pneumoniae Hungary19A-6 6029718 YP_001694692.1 CDS dprA NC_010380.1 1280994 1281842 R identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732; DNA protecting protein DprA complement(1280994..1281842) Streptococcus pneumoniae Hungary19A-6 6027730 YP_001694693.1 CDS SPH_1383 NC_010380.1 1281948 1282637 R LicC regulates expression of LPS epitopes in Haemophilus influenzae; identified by match to protein family HMM PF00483; LicC-like protein complement(1281948..1282637) Streptococcus pneumoniae Hungary19A-6 6029315 YP_001694694.1 CDS SPH_1384 NC_010380.1 1282649 1283527 R LicB regulates expression of LPS epitopes in Haemophilus influenzae; identified by match to protein family HMM PF00892; LicB-like protein complement(1282649..1283527) Streptococcus pneumoniae Hungary19A-6 6028498 YP_001694695.1 CDS SPH_1385 NC_010380.1 1283517 1284386 R identified by match to protein family HMM PF01633; match to protein family HMM PF01636; choline kinase complement(1283517..1284386) Streptococcus pneumoniae Hungary19A-6 6029755 YP_001694696.1 CDS SPH_1386 NC_010380.1 1284403 1285425 R identified by match to protein family HMM PF08240; xylitol dehydrogenase complement(1284403..1285425) Streptococcus pneumoniae Hungary19A-6 6027904 YP_001694697.1 CDS ispD NC_010380.1 1285430 1286137 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEPcytidylyltransferase; MCT; 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(1285430..1286137) Streptococcus pneumoniae Hungary19A-6 6029462 YP_001694698.1 CDS SPH_1388 NC_010380.1 1286472 1287959 D identified by match to protein family HMM PF01943; match to protein family HMM PF03023; virulence factor MviN family protein 1286472..1287959 Streptococcus pneumoniae Hungary19A-6 6029896 YP_001694699.1 CDS SPH_1389 NC_010380.1 1287969 1288772 D identified by match to protein family HMM PF04991; required for phosphorylcholine incorporation in teichoic and lipoteichoic acids 1287969..1288772 Streptococcus pneumoniae Hungary19A-6 6029944 YP_001694700.1 CDS carB NC_010380.1 1289857 1293033 R four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit complement(1289857..1293033) Streptococcus pneumoniae Hungary19A-6 6027926 YP_001694701.1 CDS carA NC_010380.1 1293346 1294425 R catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit complement(1293346..1294425) Streptococcus pneumoniae Hungary19A-6 6028661 YP_001694702.1 CDS pyrB NC_010380.1 1294475 1295398 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase complement(1294475..1295398) Streptococcus pneumoniae Hungary19A-6 6027987 YP_001694703.1 CDS SPH_1394 NC_010380.1 1295417 1295938 R regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase complement(1295417..1295938) Streptococcus pneumoniae Hungary19A-6 6028993 YP_001694704.1 CDS nth NC_010380.1 1296149 1296778 R identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01083; endonuclease III complement(1296149..1296778) Streptococcus pneumoniae Hungary19A-6 6029216 YP_001694705.1 CDS SPH_1396 NC_010380.1 1296778 1297320 R identified by match to protein family HMM PF02620; hypothetical protein complement(1296778..1297320) Streptococcus pneumoniae Hungary19A-6 6028261 YP_001694706.1 CDS SPH_1397 NC_010380.1 1297490 1297807 D BlpT protein, fusion 1297490..1297807 Streptococcus pneumoniae Hungary19A-6 6029838 YP_001694707.1 CDS SPH_1398 NC_010380.1 1298046 1299605 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1298046..1299605 Streptococcus pneumoniae Hungary19A-6 6029432 YP_001694708.1 CDS SPH_1399 NC_010380.1 1299754 1300653 R metalloprotease; heat shock protein HtpX complement(1299754..1300653) Streptococcus pneumoniae Hungary19A-6 6028986 YP_001694709.1 CDS SPH_1400 NC_010380.1 1300655 1301215 R identified by match to protein family HMM PF04011; cytoplasmic membrane protein complement(1300655..1301215) Streptococcus pneumoniae Hungary19A-6 6028316 YP_001694710.1 CDS gidB NC_010380.1 1301309 1302022 D glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1301309..1302022 Streptococcus pneumoniae Hungary19A-6 6028300 YP_001694711.1 CDS SPH_1402 NC_010380.1 1302209 1303426 R identified by match to protein family HMM PF00589; match to protein family HMM PF02920; transposase complement(1302209..1303426) Streptococcus pneumoniae Hungary19A-6 6028483 YP_001694712.1 CDS SPH_1403 NC_010380.1 1303508 1303711 R identified by match to protein family HMM PF09035; hypothetical protein complement(1303508..1303711) Streptococcus pneumoniae Hungary19A-6 6028669 YP_001694713.1 CDS SPH_1404 NC_010380.1 1303695 1303946 D hypothetical protein 1303695..1303946 Streptococcus pneumoniae Hungary19A-6 6027850 YP_001694714.1 CDS SPH_1405 NC_010380.1 1304172 1304402 R hypothetical protein complement(1304172..1304402) Streptococcus pneumoniae Hungary19A-6 6028135 YP_001694715.1 CDS SPH_1406 NC_010380.1 1304399 1304821 R identified by match to protein family HMM PF04545; match to protein family HMM PF08281; RNA polymerase sigma-70 region 4 family protein complement(1304399..1304821) Streptococcus pneumoniae Hungary19A-6 6029984 YP_001694716.1 CDS SPH_1407 NC_010380.1 1305050 1305196 R hypothetical protein complement(1305050..1305196) Streptococcus pneumoniae Hungary19A-6 6029684 YP_001694717.1 CDS SPH_1408 NC_010380.1 1305326 1305679 D identified by match to protein family HMM PF01381; transcriptional regulator 1305326..1305679 Streptococcus pneumoniae Hungary19A-6 6028509 YP_001694718.1 CDS SPH_1409 NC_010380.1 1306025 1307944 R identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM PF03764; match to protein family HMM TIGR00231; tetracycline resistance protein complement(1306025..1307944) Streptococcus pneumoniae Hungary19A-6 6028649 YP_001694719.1 CDS SPH_1410 NC_010380.1 1307960 1308076 R regulates the transcription of tet(M) by attenuation; tetracycline resistance determinant leader peptide complement(1307960..1308076) Streptococcus pneumoniae Hungary19A-6 6029337 YP_001694720.1 CDS SPH_1411 NC_010380.1 1308321 1309238 R conjugative transposon protein complement(1308321..1309238) Streptococcus pneumoniae Hungary19A-6 6028203 YP_001694721.1 CDS SPH_1412 NC_010380.1 1309253 1310254 R identified by match to protein family HMM PF00877; NLP/P60 family protein complement(1309253..1310254) Streptococcus pneumoniae Hungary19A-6 6027928 YP_001694722.1 CDS SPH_1413 NC_010380.1 1310251 1312428 R conjugative transposon membrane protein complement(1310251..1312428) Streptococcus pneumoniae Hungary19A-6 6029045 YP_001694723.1 CDS SPH_1414 NC_010380.1 1312431 1314878 R conjugative transposon protein complement(1312431..1314878) Streptococcus pneumoniae Hungary19A-6 6030072 YP_001694724.1 CDS SPH_1415 NC_010380.1 1314862 1315368 R conjugative transposon membrane protein complement(1314862..1315368) Streptococcus pneumoniae Hungary19A-6 6028489 YP_001694725.1 CDS SPH_1416 NC_010380.1 1315343 1315840 R identified by match to protein family HMM PF07275; conjugative transposon protein complement(1315343..1315840) Streptococcus pneumoniae Hungary19A-6 6028341 YP_001694726.1 CDS SPH_1417 NC_010380.1 1315957 1316178 R hypothetical protein complement(1315957..1316178) Streptococcus pneumoniae Hungary19A-6 6028127 YP_001694727.1 CDS SPH_1418 NC_010380.1 1316358 1317605 D identified by match to protein family HMM PF01610; transposase 1316358..1317605 Streptococcus pneumoniae Hungary19A-6 6030016 YP_001694728.1 CDS SPH_1419 NC_010380.1 1317726 1317917 R hypothetical protein complement(1317726..1317917) Streptococcus pneumoniae Hungary19A-6 6029410 YP_001694729.1 CDS SPH_1420 NC_010380.1 1317862 1318599 R identified by match to protein family HMM PF00398; rRNA adenine N-6-methyltransferase (macrolide-lincosamide-streptogramin B resistance protein) complement(1317862..1318599) Streptococcus pneumoniae Hungary19A-6 6029498 YP_001694730.1 CDS SPH_1422 NC_010380.1 1319046 1320275 R identified by match to protein family HMM PF01381; match to protein family HMM PF02486; Cro/CI family transcriptional regulator complement(1319046..1320275) Streptococcus pneumoniae Hungary19A-6 6029428 YP_001694731.1 CDS SPH_1423 NC_010380.1 1320453 1321838 R identified by match to protein family HMM PF01580; DNA translocase FtsK complement(1320453..1321838) Streptococcus pneumoniae Hungary19A-6 6029110 YP_001694732.1 CDS SPH_1424 NC_010380.1 1321867 1322250 R identified by match to protein family HMM PF06125; conjugative transposon protein complement(1321867..1322250) Streptococcus pneumoniae Hungary19A-6 6028934 YP_001694733.1 CDS SPH_1425 NC_010380.1 1322269 1322583 R identified by match to protein family HMM PF06125; conjugative transposon protein complement(1322269..1322583) Streptococcus pneumoniae Hungary19A-6 6027694 YP_001694734.1 CDS SPH_1426 NC_010380.1 1322606 1322725 R hypothetical protein complement(1322606..1322725) Streptococcus pneumoniae Hungary19A-6 6028971 YP_001694735.1 CDS uraA NC_010380.1 1323215 1324498 D identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; uracil permease 1323215..1324498 Streptococcus pneumoniae Hungary19A-6 6027821 YP_001694736.1 CDS ffh NC_010380.1 1324594 1326165 R identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959; signal recognition particle protein complement(1324594..1326165) Streptococcus pneumoniae Hungary19A-6 6029000 YP_001694737.1 CDS SPH_1429 NC_010380.1 1326177 1326509 R identified by match to protein family HMM PF04297; match to protein family HMM PF04967; match to protein family HMM PF08281; DNA-binding protein complement(1326177..1326509) Streptococcus pneumoniae Hungary19A-6 6028309 YP_001694738.1 CDS SPH_1430 NC_010380.1 1326600 1326977 R identified by match to protein family HMM PF09148; hypothetical protein complement(1326600..1326977) Streptococcus pneumoniae Hungary19A-6 6029213 YP_001694739.1 CDS SPH_1431 NC_010380.1 1327049 1328353 D identified by match to protein family HMM PF01966; HD superfamily phosphohydrolase 1327049..1328353 Streptococcus pneumoniae Hungary19A-6 6029912 YP_001694740.1 CDS SPH_1432 NC_010380.1 1328366 1329172 D identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; phosphatase YidA 1328366..1329172 Streptococcus pneumoniae Hungary19A-6 6029089 YP_001694741.1 CDS SPH_1433 NC_010380.1 1329215 1330213 D identified by match to protein family HMM PF02037; SAP domain-containing protein 1329215..1330213 Streptococcus pneumoniae Hungary19A-6 6029985 YP_001694742.1 CDS rplS NC_010380.1 1330493 1330840 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(1330493..1330840) Streptococcus pneumoniae Hungary19A-6 6028602 YP_001694743.1 CDS SPH_1436 NC_010380.1 1330959 1331288 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1330959..1331288) Streptococcus pneumoniae Hungary19A-6 6028169 YP_001694744.1 CDS SPH_1437 NC_010380.1 1331282 1331656 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1331282..1331656) Streptococcus pneumoniae Hungary19A-6 6028642 YP_001694745.1 CDS SPH_1438 NC_010380.1 1331653 1331919 R identified by match to protein family HMM PF01817; match to protein family HMM TIGR01805; hypothetical protein complement(1331653..1331919) Streptococcus pneumoniae Hungary19A-6 6028454 YP_001694746.1 CDS SPH_1439 NC_010380.1 1332035 1332478 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(1332035..1332478) Streptococcus pneumoniae Hungary19A-6 6027948 YP_001694747.1 CDS SPH_1440 NC_010380.1 1332582 1333517 D identified by match to protein family HMM PF01368; match to protein family HMM PF02272; DHH subfamily 1 protein 1332582..1333517 Streptococcus pneumoniae Hungary19A-6 6029091 YP_001694748.1 CDS rpmE2 NC_010380.1 1333613 1333855 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1333613..1333855 Streptococcus pneumoniae Hungary19A-6 6027909 YP_001694749.1 CDS SPH_1442 NC_010380.1 1333912 1334400 R identified by glimmer; hypothetical protein complement(1333912..1334400) Streptococcus pneumoniae Hungary19A-6 6029421 YP_001694750.1 CDS SPH_1443 NC_010380.1 1334479 1334781 R identified by glimmer; hypothetical protein complement(1334479..1334781) Streptococcus pneumoniae Hungary19A-6 6027974 YP_001694751.1 CDS SPH_1444 NC_010380.1 1334772 1335056 R identified by glimmer; hypothetical protein complement(1334772..1335056) Streptococcus pneumoniae Hungary19A-6 6028441 YP_001694752.1 CDS SPH_1445 NC_010380.1 1335193 1335459 R transposase complement(1335193..1335459) Streptococcus pneumoniae Hungary19A-6 6028225 YP_001694753.1 CDS SPH_1446 NC_010380.1 1336233 1337579 D converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1336233..1337579 Streptococcus pneumoniae Hungary19A-6 6028210 YP_001694754.1 CDS SPH_1447 NC_010380.1 1338075 1338245 R hypothetical protein complement(1338075..1338245) Streptococcus pneumoniae Hungary19A-6 6028773 YP_001694755.1 CDS SPH_1448 NC_010380.1 1338258 1338386 R identified by glimmer; hypothetical protein complement(1338258..1338386) Streptococcus pneumoniae Hungary19A-6 6029024 YP_001694756.1 CDS SPH_1450 NC_010380.1 1339441 1340037 D transposase 1339441..1340037 Streptococcus pneumoniae Hungary19A-6 6027789 YP_001694757.1 CDS SPH_1451 NC_010380.1 1340308 1340604 R identified by glimmer; hypothetical protein complement(1340308..1340604) Streptococcus pneumoniae Hungary19A-6 6028384 YP_001694758.1 CDS SPH_1452 NC_010380.1 1340617 1340760 R identified by glimmer; hypothetical protein complement(1340617..1340760) Streptococcus pneumoniae Hungary19A-6 6029726 YP_001694759.1 CDS SPH_1453 NC_010380.1 1340762 1341049 R hypothetical protein complement(1340762..1341049) Streptococcus pneumoniae Hungary19A-6 6029783 YP_001694760.1 CDS SPH_1454 NC_010380.1 1341619 1342137 D identified by match to protein family HMM PF01527; transposase subfamily protein 1341619..1342137 Streptococcus pneumoniae Hungary19A-6 6029400 YP_001694761.1 CDS SPH_1455 NC_010380.1 1342146 1342985 D identified by match to protein family HMM PF00665; integrase core subunit 1342146..1342985 Streptococcus pneumoniae Hungary19A-6 6029271 YP_001694762.1 CDS SPH_1457 NC_010380.1 1343571 1344182 R produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit D complement(1343571..1344182) Streptococcus pneumoniae Hungary19A-6 6027852 YP_001694763.1 CDS SPH_1458 NC_010380.1 1344205 1345590 R produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit B complement(1344205..1345590) Streptococcus pneumoniae Hungary19A-6 6028081 YP_001694764.1 CDS SPH_1459 NC_010380.1 1345591 1347366 R produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit A complement(1345591..1347366) Streptococcus pneumoniae Hungary19A-6 6028031 YP_001694765.1 CDS SPH_1460 NC_010380.1 1347429 1347749 R produces ATP from ADP in the presence of a proton gradient across the membrane; the F subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit F complement(1347429..1347749) Streptococcus pneumoniae Hungary19A-6 6028390 YP_001694766.1 CDS SPH_1461 NC_010380.1 1347739 1348746 R identified by match to protein family HMM PF01992; ATP synthase (C/AC39) subunit complement(1347739..1348746) Streptococcus pneumoniae Hungary19A-6 6028171 YP_001694767.1 CDS SPH_1462 NC_010380.1 1348811 1349392 R V-type sodium ATP synthase, subunit E complement(1348811..1349392) Streptococcus pneumoniae Hungary19A-6 6029994 YP_001694768.1 CDS SPH_1463 NC_010380.1 1349426 1349902 R produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits; V-type ATP synthase subunit K complement(1349426..1349902) Streptococcus pneumoniae Hungary19A-6 6028770 YP_001694769.1 CDS SPH_1464 NC_010380.1 1349918 1351909 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I is part of the membrane proton channel.; V-type ATP synthase subunit I complement(1349918..1351909) Streptococcus pneumoniae Hungary19A-6 6028581 YP_001694770.1 CDS SPH_1465 NC_010380.1 1351899 1352222 R hypothetical protein complement(1351899..1352222) Streptococcus pneumoniae Hungary19A-6 6029311 YP_001694771.1 CDS SPH_1466 NC_010380.1 1352247 1353137 R identified by match to protein family HMM PF00480; ROK family protein complement(1352247..1353137) Streptococcus pneumoniae Hungary19A-6 6029964 YP_001694772.1 CDS SPH_1467 NC_010380.1 1353294 1354403 R identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; match to protein family HMM PF03447; oxidoreductase YjhC complement(1353294..1354403) Streptococcus pneumoniae Hungary19A-6 6029237 YP_001694773.1 CDS SPH_1468 NC_010380.1 1354443 1356665 R identified by match to protein family HMM PF02012; match to protein family HMM PF02973; sialidase B (neuraminidase B) complement(1354443..1356665) Streptococcus pneumoniae Hungary19A-6 6029211 YP_001694774.1 CDS SPH_1469 NC_010380.1 1356667 1357125 R identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein complement(1356667..1357125) Streptococcus pneumoniae Hungary19A-6 6028027 YP_001694775.1 CDS SPH_1470 NC_010380.1 1357144 1358685 R identified by match to protein family HMM PF00474; match to protein family HMM TIGR00813; sodium:solute symporter family protein complement(1357144..1358685) Streptococcus pneumoniae Hungary19A-6 6028180 YP_001694776.1 CDS SPH_1471 NC_010380.1 1358713 1359630 R identified by match to protein family HMM PF00701; N-acetylneuraminate lyase complement(1358713..1359630) Streptococcus pneumoniae Hungary19A-6 6028358 YP_001694777.1 CDS SPH_1472 NC_010380.1 1359655 1360356 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(1359655..1360356) Streptococcus pneumoniae Hungary19A-6 6028969 YP_001694778.1 CDS SPH_1473 NC_010380.1 1360361 1361170 R identified by match to protein family HMM PF01380; match to protein family HMM PF01418; RpiR family transcriptional regulator complement(1360361..1361170) Streptococcus pneumoniae Hungary19A-6 6029676 YP_001694779.1 CDS SPH_1474 NC_010380.1 1361573 1362160 R identified by match to protein family HMM PF02517; CAAX amino protease complement(1361573..1362160) Streptococcus pneumoniae Hungary19A-6 6029831 YP_001694780.1 CDS SPH_1475 NC_010380.1 1362163 1362396 R hypothetical protein complement(1362163..1362396) Streptococcus pneumoniae Hungary19A-6 6028614 YP_001694781.1 CDS SPH_1476 NC_010380.1 1362652 1362789 R hypothetical protein complement(1362652..1362789) Streptococcus pneumoniae Hungary19A-6 6028282 YP_001694782.1 CDS SPH_1477 NC_010380.1 1362922 1364241 R hypothetical protein complement(1362922..1364241) Streptococcus pneumoniae Hungary19A-6 6029017 YP_001694783.1 CDS SPH_1478 NC_010380.1 1364244 1364984 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1364244..1364984) Streptococcus pneumoniae Hungary19A-6 6029323 YP_001694784.1 CDS SPH_1479 NC_010380.1 1364999 1365619 R identified by match to protein family HMM PF00005; drug efflux ABC transporter ATP-binding/permease complement(1364999..1365619) Streptococcus pneumoniae Hungary19A-6 6028524 YP_001694785.1 CDS SPH_1481 NC_010380.1 1367501 1367638 R hypothetical protein complement(1367501..1367638) Streptococcus pneumoniae Hungary19A-6 6029025 YP_001694786.1 CDS SPH_1482 NC_010380.1 1367840 1368427 R identified by match to protein family HMM PF02517; CAAX amino protease complement(1367840..1368427) Streptococcus pneumoniae Hungary19A-6 6028599 YP_001694787.1 CDS SPH_1484 NC_010380.1 1368625 1369881 D identified by match to protein family HMM PF01610; transposase 1368625..1369881 Streptococcus pneumoniae Hungary19A-6 6029625 YP_001694788.1 CDS SPH_1483 NC_010380.1 1369878 1370018 R hypothetical protein complement(1369878..1370018) Streptococcus pneumoniae Hungary19A-6 6028218 YP_001694789.1 CDS rplL NC_010380.1 1370037 1370405 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(1370037..1370405) Streptococcus pneumoniae Hungary19A-6 6029279 YP_001694790.1 CDS rplJ NC_010380.1 1370481 1370981 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(1370481..1370981) Streptococcus pneumoniae Hungary19A-6 6027745 YP_001694791.1 CDS SPH_1487 NC_010380.1 1371231 1372787 R identified by match to protein family HMM PF01979; match to protein family HMM PF07969; chlorohydrolase complement(1371231..1372787) Streptococcus pneumoniae Hungary19A-6 6029218 YP_001694792.1 CDS SPH_1488 NC_010380.1 1372882 1374630 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding/permease complement(1372882..1374630) Streptococcus pneumoniae Hungary19A-6 6029077 YP_001694793.1 CDS SPH_1489 NC_010380.1 1374632 1376356 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding/permease complement(1374632..1376356) Streptococcus pneumoniae Hungary19A-6 6029010 YP_001694794.1 CDS SPH_1490 NC_010380.1 1376414 1377352 R identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; peptide methionine sulfoxide reductase MsrA/msrB complement(1376414..1377352) Streptococcus pneumoniae Hungary19A-6 6029350 YP_001694795.1 CDS SPH_1491 NC_010380.1 1377419 1377571 R chlorohydrolase complement(1377419..1377571) Streptococcus pneumoniae Hungary19A-6 6029881 YP_001694796.1 CDS thrB NC_010380.1 1377647 1378516 R catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase complement(1377647..1378516) Streptococcus pneumoniae Hungary19A-6 6029507 YP_001694797.1 CDS SPH_1493 NC_010380.1 1378518 1379804 R catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase complement(1378518..1379804) Streptococcus pneumoniae Hungary19A-6 6027780 YP_001694798.1 CDS SPH_1494 NC_010380.1 1379955 1380692 R enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein complement(1379955..1380692) Streptococcus pneumoniae Hungary19A-6 6029689 YP_001694799.1 CDS SPH_1495 NC_010380.1 1380892 1381926 R hypothetical protein complement(1380892..1381926) Streptococcus pneumoniae Hungary19A-6 6028291 YP_001694800.1 CDS SPH_1496 NC_010380.1 1381955 1383388 R hypothetical protein complement(1381955..1383388) Streptococcus pneumoniae Hungary19A-6 6029214 YP_001694801.1 CDS SPH_1497 NC_010380.1 1383404 1384390 R identified by match to protein family HMM PF00535; galactosyl transferase paralog complement(1383404..1384390) Streptococcus pneumoniae Hungary19A-6 6029647 YP_001694802.1 CDS SPH_1498 NC_010380.1 1384392 1385492 R identified by match to protein family HMM PF00534; glycosyl transferase, group 1 family protein complement(1384392..1385492) Streptococcus pneumoniae Hungary19A-6 6028012 YP_001694803.1 CDS SPH_1499 NC_010380.1 1385485 1386330 R identified by match to protein family HMM PF04991; licD3 protein complement(1385485..1386330) Streptococcus pneumoniae Hungary19A-6 6029483 YP_001694804.1 CDS SPH_1500 NC_010380.1 1386609 1387883 R identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; LytR family transcriptional regulator complement(1386609..1387883) Streptococcus pneumoniae Hungary19A-6 6028411 YP_001694805.1 CDS SPH_1501 NC_010380.1 1387880 1388728 R catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase complement(1387880..1388728) Streptococcus pneumoniae Hungary19A-6 6028284 YP_001694806.1 CDS aroK NC_010380.1 1388725 1389201 R identified by match to protein family HMM PF01202; shikimate kinase complement(1388725..1389201) Streptococcus pneumoniae Hungary19A-6 6028179 YP_001694807.1 CDS aroA NC_010380.1 1389194 1390477 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(1389194..1390477) Streptococcus pneumoniae Hungary19A-6 6027733 YP_001694808.1 CDS SPH_1504 NC_010380.1 1390569 1390907 R identified by match to protein family HMM PF06133; hypothetical protein complement(1390569..1390907) Streptococcus pneumoniae Hungary19A-6 6028696 YP_001694809.1 CDS SPH_1505 NC_010380.1 1390918 1392021 R catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase complement(1390918..1392021) Streptococcus pneumoniae Hungary19A-6 6027785 YP_001694810.1 CDS aroC NC_010380.1 1392031 1393197 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(1392031..1393197) Streptococcus pneumoniae Hungary19A-6 6028414 YP_001694811.1 CDS aroB NC_010380.1 1393207 1394274 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(1393207..1394274) Streptococcus pneumoniae Hungary19A-6 6028737 YP_001694812.1 CDS aroE NC_010380.1 1394293 1395147 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(1394293..1395147) Streptococcus pneumoniae Hungary19A-6 6029822 YP_001694813.1 CDS aroD NC_010380.1 1395137 1395814 R catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase complement(1395137..1395814) Streptococcus pneumoniae Hungary19A-6 6029734 YP_001694814.1 CDS SPH_1510 NC_010380.1 1395811 1396974 R methyltransferase complement(1395811..1396974) Streptococcus pneumoniae Hungary19A-6 6028580 YP_001694815.1 CDS SPH_1511 NC_010380.1 1397659 1399293 R hypothetical protein complement(1397659..1399293) Streptococcus pneumoniae Hungary19A-6 6028040 YP_001694816.1 CDS SPH_1512 NC_010380.1 1399274 1400023 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1399274..1400023) Streptococcus pneumoniae Hungary19A-6 6028087 YP_001694817.1 CDS SPH_1513 NC_010380.1 1400202 1401656 D converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 1400202..1401656 Streptococcus pneumoniae Hungary19A-6 6028800 YP_001694818.1 CDS alaS NC_010380.1 1401746 1404364 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(1401746..1404364) Streptococcus pneumoniae Hungary19A-6 6029664 YP_001694819.1 CDS SPH_1515 NC_010380.1 1404386 1404871 R identified by match to protein family HMM PF04525; hypothetical protein complement(1404386..1404871) Streptococcus pneumoniae Hungary19A-6 6029730 YP_001694820.1 CDS SPH_1516 NC_010380.1 1405630 1406700 R identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein - spermidine/putrescine transport complement(1405630..1406700) Streptococcus pneumoniae Hungary19A-6 6029587 YP_001694821.1 CDS SPH_1517 NC_010380.1 1406697 1407470 R identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease complement(1406697..1407470) Streptococcus pneumoniae Hungary19A-6 6029316 YP_001694822.1 CDS SPH_1518 NC_010380.1 1407467 1408273 R identified by match to protein family HMM PF00528; ABC transporter membrane-spanning permease - spermidine/putrescine transport complement(1407467..1408273) Streptococcus pneumoniae Hungary19A-6 6029561 YP_001694823.1 CDS SPH_1519 NC_010380.1 1408254 1409411 R identified by match to protein family HMM PF00005; match to protein family HMM PF08402; spermidine/putrescine import ATP-binding protein PotA complement(1408254..1409411) Streptococcus pneumoniae Hungary19A-6 6029847 YP_001694824.1 CDS murB NC_010380.1 1409572 1410477 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(1409572..1410477) Streptococcus pneumoniae Hungary19A-6 6029939 YP_001694825.1 CDS SPH_1521 NC_010380.1 1410589 1410981 R identified by glimmer; hypothetical protein complement(1410589..1410981) Streptococcus pneumoniae Hungary19A-6 6029878 YP_001694826.1 CDS SPH_1522 NC_010380.1 1410959 1411348 R identified by glimmer; hypothetical protein complement(1410959..1411348) Streptococcus pneumoniae Hungary19A-6 6029652 YP_001694827.1 CDS budA NC_010380.1 1411358 1412089 R identified by match to protein family HMM PF03306; match to protein family HMM TIGR01252; alpha-acetolactate decarboxylase complement(1411358..1412089) Streptococcus pneumoniae Hungary19A-6 6028071 YP_001694828.1 CDS SPH_1524 NC_010380.1 1412231 1413502 D identified by match to protein family HMM PF00392; GntR family transcriptional regulator 1412231..1413502 Streptococcus pneumoniae Hungary19A-6 6027825 YP_001694829.1 CDS SPH_1525 NC_010380.1 1413522 1414337 R identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein complement(1413522..1414337) Streptococcus pneumoniae Hungary19A-6 6029653 YP_001694830.1 CDS phoU1 NC_010380.1 1414494 1415147 R identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU complement(1414494..1415147) Streptococcus pneumoniae Hungary19A-6 6027892 YP_001694831.1 CDS pstB1 NC_010380.1 1415159 1415917 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1415159..1415917) Streptococcus pneumoniae Hungary19A-6 6029472 YP_001694832.1 CDS pstB2 NC_010380.1 1415930 1416733 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1415930..1416733) Streptococcus pneumoniae Hungary19A-6 6028444 YP_001694833.1 CDS pstA1 NC_010380.1 1416744 1417628 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease PstA complement(1416744..1417628) Streptococcus pneumoniae Hungary19A-6 6028044 YP_001694834.1 CDS pstC1 NC_010380.1 1417618 1418535 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease PstC complement(1417618..1418535) Streptococcus pneumoniae Hungary19A-6 6029390 YP_001694835.1 CDS SPH_1531 NC_010380.1 1418535 1419413 R identified by match to protein family HMM PF01547; match to protein family HMM TIGR02136; phosphate-binding protein PstS 1 (PBP 1) complement(1418535..1419413) Streptococcus pneumoniae Hungary19A-6 6028582 YP_001694836.1 CDS SPH_1532 NC_010380.1 1419643 1419756 D hypothetical protein 1419643..1419756 Streptococcus pneumoniae Hungary19A-6 6029871 YP_001694837.1 CDS SPH_1533 NC_010380.1 1419987 1421291 R identified by match to protein family HMM PF01189; NOL1/NOP2/sun family protein complement(1419987..1421291) Streptococcus pneumoniae Hungary19A-6 6029273 YP_001694838.1 CDS SPH_1534 NC_010380.1 1421292 1422065 R identified by match to protein family HMM PF00459; inositol monophosphatase complement(1421292..1422065) Streptococcus pneumoniae Hungary19A-6 6029234 YP_001694839.1 CDS SPH_1535 NC_010380.1 1422055 1422333 R identified by match to protein family HMM PF05256; hypothetical protein complement(1422055..1422333) Streptococcus pneumoniae Hungary19A-6 6029960 YP_001694840.1 CDS spxA NC_010380.1 1422333 1422734 R the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx complement(1422333..1422734) Streptococcus pneumoniae Hungary19A-6 6028201 YP_001694841.1 CDS SPH_1537 NC_010380.1 1422946 1423563 R identified by match to protein family HMM PF07314; match to protein family HMM TIGR01906; hypothetical protein complement(1422946..1423563) Streptococcus pneumoniae Hungary19A-6 6028352 YP_001694842.1 CDS SPH_1538 NC_010380.1 1423553 1424326 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01457; match to protein family HMM TIGR01460; HAD family hydrolase complement(1423553..1424326) Streptococcus pneumoniae Hungary19A-6 6028777 YP_001694843.1 CDS SPH_1539 NC_010380.1 1424337 1425074 R identified by match to protein family HMM PF01643; acyl-ACP thioesterase complement(1424337..1425074) Streptococcus pneumoniae Hungary19A-6 6029223 YP_001694844.1 CDS SPH_1540 NC_010380.1 1425079 1426209 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(1425079..1426209) Streptococcus pneumoniae Hungary19A-6 6029339 YP_001694845.1 CDS SPH_1541 NC_010380.1 1426293 1426682 R hypothetical protein complement(1426293..1426682) Streptococcus pneumoniae Hungary19A-6 6028223 YP_001694846.1 CDS SPH_1542 NC_010380.1 1426698 1427081 R identified by match to protein family HMM PF06103; hypothetical protein complement(1426698..1427081) Streptococcus pneumoniae Hungary19A-6 6029352 YP_001694847.1 CDS lgt NC_010380.1 1427082 1427870 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(1427082..1427870) Streptococcus pneumoniae Hungary19A-6 6028536 YP_001694848.1 CDS hprK NC_010380.1 1427863 1428798 R catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase complement(1427863..1428798) Streptococcus pneumoniae Hungary19A-6 6029093 YP_001694849.1 CDS rpsU NC_010380.1 1428928 1429104 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(1428928..1429104) Streptococcus pneumoniae Hungary19A-6 6029631 YP_001694850.1 CDS SPH_1546 NC_010380.1 1429244 1429951 R glucosamine-6-phosphate isomerase; gnpda; glcn6p deaminase; identified by match to protein family HMM PF01182; glucosamine-6-phosphate deaminase complement(1429244..1429951) Streptococcus pneumoniae Hungary19A-6 6028655 YP_001694851.1 CDS queA NC_010380.1 1430102 1431130 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 1430102..1431130 Streptococcus pneumoniae Hungary19A-6 6028593 YP_001694852.1 CDS SPH_1548 NC_010380.1 1431791 1432180 R identified by match to protein family HMM PF01473; choline binding protein complement(1431791..1432180) Streptococcus pneumoniae Hungary19A-6 6027856 YP_001694853.1 CDS SPH_1549 NC_010380.1 1433632 1434183 R identified by match to protein family HMM PF00583; acetyltransferase complement(1433632..1434183) Streptococcus pneumoniae Hungary19A-6 6028132 YP_001694854.1 CDS nadE NC_010380.1 1434581 1435405 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1434581..1435405) Streptococcus pneumoniae Hungary19A-6 6029111 YP_001694855.1 CDS pncB NC_010380.1 1435402 1436862 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1435402..1436862) Streptococcus pneumoniae Hungary19A-6 6028387 YP_001694856.1 CDS SPH_1552 NC_010380.1 1436978 1437466 R hypothetical protein complement(1436978..1437466) Streptococcus pneumoniae Hungary19A-6 6029320 YP_001694857.1 CDS SPH_1553 NC_010380.1 1437456 1437665 R identified by match to protein family HMM PF01381; hypothetical protein complement(1437456..1437665) Streptococcus pneumoniae Hungary19A-6 6029673 YP_001694858.1 CDS SPH_1554 NC_010380.1 1438051 1438779 R hypothetical protein complement(1438051..1438779) Streptococcus pneumoniae Hungary19A-6 6028691 YP_001694859.1 CDS SPH_1555 NC_010380.1 1438795 1439514 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein - multidrug efflux complement(1438795..1439514) Streptococcus pneumoniae Hungary19A-6 6028874 YP_001694860.1 CDS SPH_1556 NC_010380.1 1440021 1440746 R identified by match to protein family HMM PF01136; U32 family peptidase complement(1440021..1440746) Streptococcus pneumoniae Hungary19A-6 6028833 YP_001694861.1 CDS SPH_1557 NC_010380.1 1440931 1441080 D hypothetical protein 1440931..1441080 Streptococcus pneumoniae Hungary19A-6 6029729 YP_001694862.1 CDS SPH_1558 NC_010380.1 1441335 1442621 R identified by match to protein family HMM PF01136; peptidase, U32 family protein complement(1441335..1442621) Streptococcus pneumoniae Hungary19A-6 6028008 YP_001694863.1 CDS SPH_1561 NC_010380.1 1443796 1444986 D identified by match to protein family HMM PF01555; DNA modification methyltransferase M.XbaI 1443796..1444986 Streptococcus pneumoniae Hungary19A-6 6029737 YP_001694864.1 CDS guaA NC_010380.1 1445062 1446624 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(1445062..1446624) Streptococcus pneumoniae Hungary19A-6 6028616 YP_001694865.1 CDS SPH_1563 NC_010380.1 1446766 1447464 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 1446766..1447464 Streptococcus pneumoniae Hungary19A-6 6029126 YP_001694866.1 CDS SPH_1564 NC_010380.1 1447507 1448403 R identified by match to protein family HMM PF00892; membrane protein complement(1447507..1448403) Streptococcus pneumoniae Hungary19A-6 6029443 YP_001694867.1 CDS SPH_1565 NC_010380.1 1448412 1449347 R identified by match to protein family HMM PF00144; beta-lactamase complement(1448412..1449347) Streptococcus pneumoniae Hungary19A-6 6028006 YP_001694868.1 CDS SPH_1566 NC_010380.1 1449344 1450069 R CppA protein complement(1449344..1450069) Streptococcus pneumoniae Hungary19A-6 6029758 YP_001694869.1 CDS SPH_1567 NC_010380.1 1450153 1450788 R identified by match to protein family HMM PF00657; hypothetical protein complement(1450153..1450788) Streptococcus pneumoniae Hungary19A-6 6029281 YP_001694870.1 CDS SPH_1568 NC_010380.1 1450790 1451617 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; HAD family hydrolase complement(1450790..1451617) Streptococcus pneumoniae Hungary19A-6 6029543 YP_001694871.1 CDS SPH_1571 NC_010380.1 1452768 1452881 D hypothetical protein 1452768..1452881 Streptococcus pneumoniae Hungary19A-6 6028981 YP_001694872.1 CDS def NC_010380.1 1453205 1453816 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1453205..1453816 Streptococcus pneumoniae Hungary19A-6 6028443 YP_001694873.1 CDS SPH_1573 NC_010380.1 1453861 1454589 D identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; RNA methyltransferase 1453861..1454589 Streptococcus pneumoniae Hungary19A-6 6027829 YP_001694874.1 CDS trxB NC_010380.1 1454628 1455539 R identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01292; thioredoxin-disulfide reductase complement(1454628..1455539) Streptococcus pneumoniae Hungary19A-6 6029588 YP_001694875.1 CDS SPH_1575 NC_010380.1 1455605 1455829 R hypothetical protein complement(1455605..1455829) Streptococcus pneumoniae Hungary19A-6 6029974 YP_001694876.1 CDS SPH_1576 NC_010380.1 1455907 1456650 R identified by match to protein family HMM PF00005; L-cystine import ATP-binding protein TcyN complement(1455907..1456650) Streptococcus pneumoniae Hungary19A-6 6029138 YP_001694877.1 CDS SPH_1577 NC_010380.1 1456650 1457450 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; ABC transporter membrane-spanning permease - aspartate/glutamate transport complement(1456650..1457450) Streptococcus pneumoniae Hungary19A-6 6029368 YP_001694878.1 CDS SPH_1578 NC_010380.1 1457608 1457964 R identified by match to protein family HMM PF03960; match to protein family HMM TIGR01617; arsenate reductase complement(1457608..1457964) Streptococcus pneumoniae Hungary19A-6 6029096 YP_001694879.1 CDS SPH_1579 NC_010380.1 1457977 1458489 R identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589; O6-methylguanine-DNA methyltransferase complement(1457977..1458489) Streptococcus pneumoniae Hungary19A-6 6028433 YP_001694880.1 CDS SPH_1580 NC_010380.1 1458489 1458983 R identified by match to protein family HMM PF00583; acetyltransferase complement(1458489..1458983) Streptococcus pneumoniae Hungary19A-6 6028544 YP_001694881.1 CDS SPH_1581 NC_010380.1 1459118 1459564 D identified by match to protein family HMM PF08876; hypothetical protein 1459118..1459564 Streptococcus pneumoniae Hungary19A-6 6028573 YP_001694882.1 CDS SPH_1582 NC_010380.1 1459561 1460208 D identified by match to protein family HMM PF03006; match to protein family HMM TIGR01065; hemolysin-3 (hemolysin III) (Hly-III) 1459561..1460208 Streptococcus pneumoniae Hungary19A-6 6030007 YP_001694883.1 CDS SPH_1583 NC_010380.1 1460229 1460810 R with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT complement(1460229..1460810) Streptococcus pneumoniae Hungary19A-6 6027830 YP_001694884.1 CDS SPH_1584 NC_010380.1 1460811 1461686 R with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS complement(1460811..1461686) Streptococcus pneumoniae Hungary19A-6 6029773 YP_001694885.1 CDS SPH_1585 NC_010380.1 1461838 1463217 R identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; NADH oxidase (noxase) complement(1461838..1463217) Streptococcus pneumoniae Hungary19A-6 6028421 YP_001694886.1 CDS SPH_1586 NC_010380.1 1463511 1464434 D identified by match to protein family HMM PF02424; thiamine biosynthesis lipoprotein 1463511..1464434 Streptococcus pneumoniae Hungary19A-6 6029371 YP_001694887.1 CDS SPH_1587 NC_010380.1 1464494 1465099 D identified by match to protein family HMM PF03358; NADPH-dependent FMN reductase domain-containing protein 1464494..1465099 Streptococcus pneumoniae Hungary19A-6 6029851 YP_001694888.1 CDS SPH_1588 NC_010380.1 1465118 1466362 D identified by match to protein family HMM PF03358; NADPH-dependent FMN reductase domain-containing protein 1465118..1466362 Streptococcus pneumoniae Hungary19A-6 6028689 YP_001694889.1 CDS SPH_1589 NC_010380.1 1466478 1466735 R identified by match to protein family HMM PF05979; hypothetical protein complement(1466478..1466735) Streptococcus pneumoniae Hungary19A-6 6028020 YP_001694890.1 CDS glyS NC_010380.1 1466777 1468813 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(1466777..1468813) Streptococcus pneumoniae Hungary19A-6 6028045 YP_001694891.1 CDS glyQ NC_010380.1 1469025 1469942 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(1469025..1469942) Streptococcus pneumoniae Hungary19A-6 6030059 YP_001694892.1 CDS SPH_1592 NC_010380.1 1470136 1470897 R hypothetical protein complement(1470136..1470897) Streptococcus pneumoniae Hungary19A-6 6028741 YP_001694893.1 CDS SPH_1593 NC_010380.1 1471170 1472012 R 2,5-dkgreductase a; 2,5-dkgr a; 25dkgr-a; akr5c; identified by match to protein family HMM PF00248; 2,5-diketo-D-gluconate reductase A complement(1471170..1472012) Streptococcus pneumoniae Hungary19A-6 6027981 YP_001694894.1 CDS SPH_1594 NC_010380.1 1472126 1473463 R identified by match to protein family HMM PF01522; peptidoglycan GlcNAc deacetylase complement(1472126..1473463) Streptococcus pneumoniae Hungary19A-6 6029724 YP_001694895.1 CDS SPH_1595 NC_010380.1 1473752 1474105 R hypothetical protein complement(1473752..1474105) Streptococcus pneumoniae Hungary19A-6 6029085 YP_001694896.1 CDS SPH_1596 NC_010380.1 1474362 1475339 D identified by match to protein family HMM PF01408; oxidoreductase 1474362..1475339 Streptococcus pneumoniae Hungary19A-6 6027782 YP_001694897.1 CDS SPH_1597 NC_010380.1 1475336 1476418 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; DEAD RNA helicase 1475336..1476418 Streptococcus pneumoniae Hungary19A-6 6029244 YP_001694898.1 CDS SPH_1598 NC_010380.1 1476482 1477135 R transposase complement(1476482..1477135) Streptococcus pneumoniae Hungary19A-6 6029640 YP_001694899.1 CDS tuf NC_010380.1 1477912 1479108 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(1477912..1479108) Streptococcus pneumoniae Hungary19A-6 6028419 YP_001694900.1 CDS SPH_1602 NC_010380.1 1479451 1479573 R hypothetical protein complement(1479451..1479573) Streptococcus pneumoniae Hungary19A-6 6027954 YP_001694901.1 CDS SPH_1603 NC_010380.1 1480019 1480888 R identified by match to protein family HMM PF00230; glycerol facilitator-aquaporin gla (aquaglyceroporin)(glyceroaquaporin) complement(1480019..1480888) Streptococcus pneumoniae Hungary19A-6 6029659 YP_001694902.1 CDS SPH_1604 NC_010380.1 1481112 1481789 R identified by match to protein family HMM PF00746; match to protein family HMM PF06458; match to protein family HMM TIGR01167; MucBP domain-contain protein complement(1481112..1481789) Streptococcus pneumoniae Hungary19A-6 6028321 YP_001694903.1 CDS SPH_1605 NC_010380.1 1481747 1482826 R hypothetical protein complement(1481747..1482826) Streptococcus pneumoniae Hungary19A-6 6029494 YP_001694904.1 CDS SPH_1606 NC_010380.1 1482937 1483215 R hypothetical protein complement(1482937..1483215) Streptococcus pneumoniae Hungary19A-6 6028798 YP_001694905.1 CDS SPH_1610 NC_010380.1 1484611 1486329 D identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880; phosphoglucomutase/phosphomannomutase alpha/beta/subunit 1484611..1486329 Streptococcus pneumoniae Hungary19A-6 6029914 YP_001694906.1 CDS SPH_1611 NC_010380.1 1486440 1486787 D identified by match to protein family HMM TIGR01295; bacterocin transport accessory protein 1486440..1486787 Streptococcus pneumoniae Hungary19A-6 6027984 YP_001694907.1 CDS SPH_1612 NC_010380.1 1487065 1487901 R identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein - glutamine transport complement(1487065..1487901) Streptococcus pneumoniae Hungary19A-6 6028319 YP_001694908.1 CDS SPH_1613 NC_010380.1 1487914 1488543 R identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ complement(1487914..1488543) Streptococcus pneumoniae Hungary19A-6 6028670 YP_001694909.1 CDS SPH_1614 NC_010380.1 1488553 1489194 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease complement(1488553..1489194) Streptococcus pneumoniae Hungary19A-6 6029934 YP_001694910.1 CDS SPH_1615 NC_010380.1 1489340 1490569 R identified by match to protein family HMM PF00515; match to protein family HMM PF07719; TPR domain-containing protein complement(1489340..1490569) Streptococcus pneumoniae Hungary19A-6 6029573 YP_001694911.1 CDS SPH_1616 NC_010380.1 1490559 1491725 R identified by match to protein family HMM PF01594; transport protein complement(1490559..1491725) Streptococcus pneumoniae Hungary19A-6 6029489 YP_001694912.1 CDS SPH_1617 NC_010380.1 1491869 1492882 D 3-carboxymuconate cyclase 1491869..1492882 Streptococcus pneumoniae Hungary19A-6 6028613 YP_001694913.1 CDS atpC NC_010380.1 1492927 1493346 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon complement(1492927..1493346) Streptococcus pneumoniae Hungary19A-6 6029246 YP_001694914.1 CDS atpD NC_010380.1 1493357 1494763 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta complement(1493357..1494763) Streptococcus pneumoniae Hungary19A-6 6028575 YP_001694915.1 CDS atpG NC_010380.1 1494849 1495727 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma complement(1494849..1495727) Streptococcus pneumoniae Hungary19A-6 6029792 YP_001694916.1 CDS atpA NC_010380.1 1495743 1497248 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha complement(1495743..1497248) Streptococcus pneumoniae Hungary19A-6 6029784 YP_001694917.1 CDS atpH NC_010380.1 1497263 1497799 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta complement(1497263..1497799) Streptococcus pneumoniae Hungary19A-6 6028420 YP_001694918.1 CDS atpF NC_010380.1 1497799 1498293 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B complement(1497799..1498293) Streptococcus pneumoniae Hungary19A-6 6028112 YP_001694919.1 CDS atpB NC_010380.1 1498307 1499023 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A complement(1498307..1499023) Streptococcus pneumoniae Hungary19A-6 6028116 YP_001694920.1 CDS SPH_1625 NC_010380.1 1499058 1499258 R produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C complement(1499058..1499258) Streptococcus pneumoniae Hungary19A-6 6028903 YP_001694921.1 CDS SPH_1626 NC_010380.1 1499333 1500340 R identified by match to protein family HMM PF00665; transposase complement(1499333..1500340) Streptococcus pneumoniae Hungary19A-6 6027882 YP_001694922.1 CDS SPH_1627 NC_010380.1 1500761 1501159 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family protein complement(1500761..1501159) Streptococcus pneumoniae Hungary19A-6 6027721 YP_001694923.1 CDS SPH_1628 NC_010380.1 1501277 1501729 R identified by glimmer; hypothetical protein complement(1501277..1501729) Streptococcus pneumoniae Hungary19A-6 6028880 YP_001694924.1 CDS greA NC_010380.1 1501757 1502239 R Transcript cleavage factor greA; General stress protein 20M; GSP20M; necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1501757..1502239) Streptococcus pneumoniae Hungary19A-6 6028958 YP_001694925.1 CDS SPH_1630 NC_010380.1 1502310 1503965 R identified by match to protein family HMM PF02618; match to protein family HMM TIGR00247; aminodeoxychorismate lyase complement(1502310..1503965) Streptococcus pneumoniae Hungary19A-6 6028366 YP_001694926.1 CDS SPH_1631 NC_010380.1 1504046 1504540 R identified by match to protein family HMM PF00583; acetyltransferase complement(1504046..1504540) Streptococcus pneumoniae Hungary19A-6 6028393 YP_001694927.1 CDS SPH_1632 NC_010380.1 1504537 1505001 R identified by match to protein family HMM PF00583; acetyltransferase complement(1504537..1505001) Streptococcus pneumoniae Hungary19A-6 6030077 YP_001694928.1 CDS murC NC_010380.1 1505011 1506345 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(1505011..1506345) Streptococcus pneumoniae Hungary19A-6 6027769 YP_001694929.1 CDS SPH_1634 NC_010380.1 1506356 1506973 R hypothetical protein complement(1506356..1506973) Streptococcus pneumoniae Hungary19A-6 6028685 YP_001694930.1 CDS SPH_1635 NC_010380.1 1507021 1510119 R identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434; match to protein family HMM PF08455; Snf2 family protein complement(1507021..1510119) Streptococcus pneumoniae Hungary19A-6 6029155 YP_001694931.1 CDS SPH_1636 NC_010380.1 1510212 1511378 R identified by match to protein family HMM PF00155; aminotransferase B complement(1510212..1511378) Streptococcus pneumoniae Hungary19A-6 6029499 YP_001694932.1 CDS SPH_1637 NC_010380.1 1511386 1512480 R catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase complement(1511386..1512480) Streptococcus pneumoniae Hungary19A-6 6028706 YP_001694933.1 CDS SPH_1641 NC_010380.1 1514484 1516442 R identified by match to protein family HMM PF00496; oligopeptide binding lipoprotein complement(1514484..1516442) Streptococcus pneumoniae Hungary19A-6 6028164 YP_001694934.1 CDS SPH_1642 NC_010380.1 1516646 1518283 R identified by match to protein family HMM PF01943; match to protein family HMM PF03023; polysaccharide transporter complement(1516646..1518283) Streptococcus pneumoniae Hungary19A-6 6029162 YP_001694935.1 CDS SPH_1643 NC_010380.1 1518374 1519819 D UDP-N-acetylmuramyl-tripeptide synthetase; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-tripeptide synthetase; involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1518374..1519819 Streptococcus pneumoniae Hungary19A-6 6029798 YP_001694936.1 CDS SPH_1644 NC_010380.1 1519865 1520059 R identified by match to protein family HMM PF05532; hypothetical protein complement(1519865..1520059) Streptococcus pneumoniae Hungary19A-6 6030067 YP_001694937.1 CDS SPH_1645 NC_010380.1 1520253 1520444 R identified by glimmer; hypothetical protein complement(1520253..1520444) Streptococcus pneumoniae Hungary19A-6 6029447 YP_001694938.1 CDS SPH_1647 NC_010380.1 1520793 1521305 R hypothetical protein complement(1520793..1521305) Streptococcus pneumoniae Hungary19A-6 6028796 YP_001694939.1 CDS SPH_1648 NC_010380.1 1521391 1522326 R catalyzes the hydrolysis of pyrophosphate to phosphate; manganese-dependent inorganic pyrophosphatase complement(1521391..1522326) Streptococcus pneumoniae Hungary19A-6 6029312 YP_001694940.1 CDS SPH_1649 NC_010380.1 1522397 1522696 R identified by match to protein family HMM PF01541; hypothetical protein complement(1522397..1522696) Streptococcus pneumoniae Hungary19A-6 6030055 YP_001694941.1 CDS SPH_1650 NC_010380.1 1522686 1523435 R identified by match to protein family HMM PF05175; methyltransferase complement(1522686..1523435) Streptococcus pneumoniae Hungary19A-6 6030024 YP_001694942.1 CDS SPH_1651 NC_010380.1 1523489 1523875 R identified by match to protein family HMM PF00575; hypothetical protein complement(1523489..1523875) Streptococcus pneumoniae Hungary19A-6 6028759 YP_001694943.1 CDS SPH_1652 NC_010380.1 1523850 1525250 R identified by match to protein family HMM PF00160; match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein/peptidyl-prolyl cis-trans isomerase, cyclophilin type complement(1523850..1525250) Streptococcus pneumoniae Hungary19A-6 6027903 YP_001694944.1 CDS rpsR NC_010380.1 1525544 1525783 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(1525544..1525783) Streptococcus pneumoniae Hungary19A-6 6029967 YP_001694945.1 CDS SPH_1654 NC_010380.1 1525815 1526285 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1525815..1526285) Streptococcus pneumoniae Hungary19A-6 6027716 YP_001694946.1 CDS rpsF NC_010380.1 1526297 1526587 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(1526297..1526587) Streptococcus pneumoniae Hungary19A-6 6028270 YP_001694947.1 CDS asnC NC_010380.1 1526740 1528083 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(1526740..1528083) Streptococcus pneumoniae Hungary19A-6 6029708 YP_001694948.1 CDS SPH_1657 NC_010380.1 1528103 1528468 R identified by match to protein family HMM PF00903; glyoxalase complement(1528103..1528468) Streptococcus pneumoniae Hungary19A-6 6028470 YP_001694949.1 CDS SPH_1658 NC_010380.1 1528461 1529648 R catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase complement(1528461..1529648) Streptococcus pneumoniae Hungary19A-6 6030042 YP_001694950.1 CDS SPH_1659 NC_010380.1 1529645 1530133 R identified by match to protein family HMM PF03413; peptidase propeptide/YPEB domain-containing protein complement(1529645..1530133) Streptococcus pneumoniae Hungary19A-6 6028158 YP_001694951.1 CDS SPH_1660 NC_010380.1 1530200 1530316 R identified by glimmer; hypothetical protein complement(1530200..1530316) Streptococcus pneumoniae Hungary19A-6 6030064 YP_001694952.1 CDS SPH_1661 NC_010380.1 1530454 1531002 D identified by match to protein family HMM PF02525; match to protein family HMM PF03358; oxidoreductase 1530454..1531002 Streptococcus pneumoniae Hungary19A-6 6029074 YP_001694953.1 CDS SPH_1662 NC_010380.1 1531280 1532008 R identified by match to protein family HMM PF03883; hypothetical protein complement(1531280..1532008) Streptococcus pneumoniae Hungary19A-6 6028722 YP_001694954.1 CDS SPH_1663 NC_010380.1 1532087 1532251 R hypothetical protein complement(1532087..1532251) Streptococcus pneumoniae Hungary19A-6 6029098 YP_001694955.1 CDS SPH_1664 NC_010380.1 1532318 1533913 R hypothetical protein complement(1532318..1533913) Streptococcus pneumoniae Hungary19A-6 6028106 YP_001694956.1 CDS def2 NC_010380.1 1533925 1534335 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(1533925..1534335) Streptococcus pneumoniae Hungary19A-6 6029379 YP_001694957.1 CDS SPH_1666 NC_010380.1 1534451 1535242 R YghU; B2989; one of eight glutathione transferases from E. coli; glutathione S-transferase YghU complement(1534451..1535242) Streptococcus pneumoniae Hungary19A-6 6029622 YP_001694958.1 CDS SPH_1667 NC_010380.1 1535255 1537951 R identified by match to protein family HMM PF00122; match to protein family HMM PF00689; match to protein family HMM PF00690; match to protein family HMM PF00702; match to protein family HMM TIGR01494; calcium-transporting ATPase 1 (Golgi Ca(2+)-ATPase) complement(1535255..1537951) Streptococcus pneumoniae Hungary19A-6 6029125 YP_001694959.1 CDS SPH_1668 NC_010380.1 1538255 1539439 D identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation efflux family protein 1538255..1539439 Streptococcus pneumoniae Hungary19A-6 6028899 YP_001694960.1 CDS SPH_1669 NC_010380.1 1539582 1541453 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1539582..1541453) Streptococcus pneumoniae Hungary19A-6 6029862 YP_001694961.1 CDS SPH_1670 NC_010380.1 1541450 1542634 R catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase complement(1541450..1542634) Streptococcus pneumoniae Hungary19A-6 6028718 YP_001694962.1 CDS dapB NC_010380.1 1542646 1543413 R catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase complement(1542646..1543413) Streptococcus pneumoniae Hungary19A-6 6028064 YP_001694963.1 CDS SPH_1672 NC_010380.1 1543690 1544538 R identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; hypothetical protein complement(1543690..1544538) Streptococcus pneumoniae Hungary19A-6 6028206 YP_001694964.1 CDS SPH_1673 NC_010380.1 1544540 1544914 R identified by match to protein family HMM PF06619; hypothetical protein complement(1544540..1544914) Streptococcus pneumoniae Hungary19A-6 6027744 YP_001694965.1 CDS glmM NC_010380.1 1544988 1546340 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(1544988..1546340) Streptococcus pneumoniae Hungary19A-6 6028583 YP_001694966.1 CDS SPH_1675 NC_010380.1 1546364 1547143 R identified by match to protein family HMM PF07949; lipoprotein complement(1546364..1547143) Streptococcus pneumoniae Hungary19A-6 6029526 YP_001694967.1 CDS SPH_1676 NC_010380.1 1547130 1547987 R identified by match to protein family HMM PF02457; match to protein family HMM TIGR00159; hypothetical protein complement(1547130..1547987) Streptococcus pneumoniae Hungary19A-6 6029529 YP_001694968.1 CDS SPH_1677 NC_010380.1 1548123 1549091 D identified by match to protein family HMM PF00070; match to protein family HMM PF03486; match to protein family HMM PF07992; thioredoxin reductase 1548123..1549091 Streptococcus pneumoniae Hungary19A-6 6029129 YP_001694969.1 CDS SPH_1678 NC_010380.1 1549125 1550036 R identified by match to protein family HMM PF02650; match to protein family HMM TIGR00647; hypothetical protein complement(1549125..1550036) Streptococcus pneumoniae Hungary19A-6 6028204 YP_001694970.1 CDS SPH_1679 NC_010380.1 1550033 1551010 R identified by match to protein family HMM PF01933; match to protein family HMM TIGR01826; transporter complement(1550033..1551010) Streptococcus pneumoniae Hungary19A-6 6029515 YP_001694971.1 CDS SPH_1680 NC_010380.1 1551007 1551897 R identified by match to protein family HMM PF03668; hypothetical protein complement(1551007..1551897) Streptococcus pneumoniae Hungary19A-6 6028871 YP_001694972.1 CDS SPH_1681 NC_010380.1 1551949 1552329 R identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004; endoribonuclease L-PSP complement(1551949..1552329) Streptococcus pneumoniae Hungary19A-6 6028313 YP_001694973.1 CDS engB NC_010380.1 1552340 1552927 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(1552340..1552927) Streptococcus pneumoniae Hungary19A-6 6027864 YP_001694974.1 CDS clpX NC_010380.1 1552936 1554144 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1552936..1554144) Streptococcus pneumoniae Hungary19A-6 6029021 YP_001694975.1 CDS SPH_1684 NC_010380.1 1554205 1554375 R hypothetical protein complement(1554205..1554375) Streptococcus pneumoniae Hungary19A-6 6028377 YP_001694976.1 CDS folA NC_010380.1 1554375 1554881 R identified by match to protein family HMM PF00186; dihydrofolate reductase complement(1554375..1554881) Streptococcus pneumoniae Hungary19A-6 6028852 YP_001694977.1 CDS SPH_1686 NC_010380.1 1555011 1555529 R identified by match to protein family HMM PF00210; DNA protection during starvation protein complement(1555011..1555529) Streptococcus pneumoniae Hungary19A-6 6028961 YP_001694978.1 CDS SPH_1687 NC_010380.1 1556026 1557498 R identified by glimmer; hypothetical protein complement(1556026..1557498) Streptococcus pneumoniae Hungary19A-6 6029201 YP_001694979.1 CDS tpiA NC_010380.1 1557569 1558327 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(1557569..1558327) Streptococcus pneumoniae Hungary19A-6 6029952 YP_001694980.1 CDS SPH_1689 NC_010380.1 1558425 1559102 R identified by match to protein family HMM PF04271; match to protein family HMM TIGR01446; DNA replication protein DnaD complement(1558425..1559102) Streptococcus pneumoniae Hungary19A-6 6028531 YP_001694981.1 CDS metA NC_010380.1 1559111 1560055 R catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase complement(1559111..1560055) Streptococcus pneumoniae Hungary19A-6 6027751 YP_001694982.1 CDS apt NC_010380.1 1560237 1560749 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(1560237..1560749) Streptococcus pneumoniae Hungary19A-6 6030017 YP_001694983.1 CDS SPH_1692 NC_010380.1 1560836 1561594 R identified by match to protein family HMM PF08241; match to protein family HMM PF08242; SAM-dependent methyltransferase complement(1560836..1561594) Streptococcus pneumoniae Hungary19A-6 6029156 YP_001694984.1 CDS SPH_1693 NC_010380.1 1561802 1561972 D hypothetical protein 1561802..1561972 Streptococcus pneumoniae Hungary19A-6 6027719 YP_001694985.1 CDS SPH_1694 NC_010380.1 1562095 1563225 R identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; multiple sugar-binding transport ATP-binding protein MsmK complement(1562095..1563225) Streptococcus pneumoniae Hungary19A-6 6029709 YP_001694986.1 CDS SPH_1696 NC_010380.1 1563675 1564250 R identified by match to protein family HMM PF00857; isochorismatase complement(1563675..1564250) Streptococcus pneumoniae Hungary19A-6 6028552 YP_001694987.1 CDS codY NC_010380.1 1564250 1565038 R CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY complement(1564250..1565038) Streptococcus pneumoniae Hungary19A-6 6028818 YP_001694988.1 CDS SPH_1698 NC_010380.1 1565303 1566877 R identified by match to protein family HMM PF00270; match to protein family HMM PF00271; DEAD/DEAH box helicase complement(1565303..1566877) Streptococcus pneumoniae Hungary19A-6 6028286 YP_001694989.1 CDS SPH_1699 NC_010380.1 1567076 1568302 R identified by match to protein family HMM PF07690; major facilitator:oxalate:formate antiporter complement(1567076..1568302) Streptococcus pneumoniae Hungary19A-6 6029941 YP_001694990.1 CDS SPH_1700 NC_010380.1 1568494 1569810 D Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 1568494..1569810 Streptococcus pneumoniae Hungary19A-6 6029572 YP_001694991.1 CDS SPH_1701 NC_010380.1 1569909 1571252 D identified by match to protein family HMM PF08245; match to protein family HMM PF08353; Mur ligase 1569909..1571252 Streptococcus pneumoniae Hungary19A-6 6028463 YP_001694992.1 CDS SPH_1702 NC_010380.1 1571252 1572034 D identified by match to protein family HMM PF07685; cobyric acid synthase 1571252..1572034 Streptococcus pneumoniae Hungary19A-6 6029649 YP_001694993.1 CDS SPH_1703 NC_010380.1 1572160 1573242 D X-Pro dipeptidase; Prolinedipeptidase; Prolidase; Imidodipeptidase; identified by match to protein family HMM PF00557; match to protein family HMM PF01321; Xaa-Pro dipeptidase 1572160..1573242 Streptococcus pneumoniae Hungary19A-6 6027753 YP_001694994.1 CDS SPH_1709 NC_010380.1 1575053 1575514 R hypothetical protein complement(1575053..1575514) Streptococcus pneumoniae Hungary19A-6 6029290 YP_001694995.1 CDS SPH_1710 NC_010380.1 1575492 1576265 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(1575492..1576265) Streptococcus pneumoniae Hungary19A-6 6028755 YP_001694996.1 CDS truA NC_010380.1 1576255 1577004 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(1576255..1577004) Streptococcus pneumoniae Hungary19A-6 6028262 YP_001694997.1 CDS SPH_1713 NC_010380.1 1577184 1577345 D hypothetical protein 1577184..1577345 Streptococcus pneumoniae Hungary19A-6 6028129 YP_001694998.1 CDS SPH_1712 NC_010380.1 1577317 1578468 R identified by match to protein family HMM PF07690; major facilitator transporter complement(1577317..1578468) Streptococcus pneumoniae Hungary19A-6 6028956 YP_001694999.1 CDS SPH_1714 NC_010380.1 1578708 1579337 R hypothetical protein complement(1578708..1579337) Streptococcus pneumoniae Hungary19A-6 6030028 YP_001695000.1 CDS phnA NC_010380.1 1579340 1579678 R identified by match to protein family HMM PF03831; match to protein family HMM PF08274; match to protein family HMM TIGR00686; alkylphosphonate utilization protein PhnA complement(1579340..1579678) Streptococcus pneumoniae Hungary19A-6 6028529 YP_001695001.1 CDS cmk NC_010380.1 1579809 1580480 R Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase complement(1579809..1580480) Streptococcus pneumoniae Hungary19A-6 6029487 YP_001695002.1 CDS SPH_1717 NC_010380.1 1580489 1580965 R hypothetical protein complement(1580489..1580965) Streptococcus pneumoniae Hungary19A-6 6028039 YP_001695003.1 CDS SPH_1718 NC_010380.1 1581107 1581223 D ferredoxin 1581107..1581223 Streptococcus pneumoniae Hungary19A-6 6028347 YP_001695004.1 CDS SPH_1719 NC_010380.1 1581285 1582238 R identified by match to protein family HMM PF00535; bactoprenol glucosyl transferase complement(1581285..1582238) Streptococcus pneumoniae Hungary19A-6 6029691 YP_001695005.1 CDS galE NC_010380.1 1582240 1583259 R identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase complement(1582240..1583259) Streptococcus pneumoniae Hungary19A-6 6029325 YP_001695006.1 CDS SPH_1722 NC_010380.1 1583560 1584663 R identified by match to protein family HMM PF01266; oxidoreductase, DadA family protein complement(1583560..1584663) Streptococcus pneumoniae Hungary19A-6 6028745 YP_001695007.1 CDS SPH_1723 NC_010380.1 1584680 1585477 R identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486; hypothetical protein complement(1584680..1585477) Streptococcus pneumoniae Hungary19A-6 6030056 YP_001695008.1 CDS SPH_1724 NC_010380.1 1585464 1586141 R identified by match to protein family HMM PF04816; bcl-2 family protein complement(1585464..1586141) Streptococcus pneumoniae Hungary19A-6 6027823 YP_001695009.1 CDS SPH_1726 NC_010380.1 1587755 1588588 R identified by match to protein family HMM PF00665; integrase core subunit complement(1587755..1588588) Streptococcus pneumoniae Hungary19A-6 6028682 YP_001695010.1 CDS tkt1 NC_010380.1 1589477 1591447 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(1589477..1591447) Streptococcus pneumoniae Hungary19A-6 6029679 YP_001695011.1 CDS SPH_1730 NC_010380.1 1591484 1592179 R identified by match to protein family HMM PF00834; allulose-6-phosphate 3-epimerase complement(1591484..1592179) Streptococcus pneumoniae Hungary19A-6 6029076 YP_001695012.1 CDS SPH_1731 NC_010380.1 1592190 1593275 R identified by match to protein family HMM PF02378; match to protein family HMM TIGR01427; PTS system, IIC component complement(1592190..1593275) Streptococcus pneumoniae Hungary19A-6 6029419 YP_001695013.1 CDS SPH_1733 NC_010380.1 1593640 1594089 R identified by match to protein family HMM PF00359; match to protein family HMM TIGR00848; PTS system, IIA component complement(1593640..1594089) Streptococcus pneumoniae Hungary19A-6 6028152 YP_001695014.1 CDS SPH_1734 NC_010380.1 1594067 1594495 R identified by match to protein family HMM PF00359; PTS system, nitrogen regulatory component IIA complement(1594067..1594495) Streptococcus pneumoniae Hungary19A-6 6029715 YP_001695015.1 CDS SPH_1735 NC_010380.1 1594488 1595951 R identified by match to protein family HMM PF00874; match to protein family HMM PF05043; match to protein family HMM PF08279; transcription antiterminator BglG family protein complement(1594488..1595951) Streptococcus pneumoniae Hungary19A-6 6028556 YP_001695016.1 CDS SPH_1736 NC_010380.1 1596480 1598816 R identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; cation transport ATPase complement(1596480..1598816) Streptococcus pneumoniae Hungary19A-6 6028617 YP_001695017.1 CDS SPH_1737 NC_010380.1 1598949 1599698 D identified by match to protein family HMM PF01553; acyltransferase 1598949..1599698 Streptococcus pneumoniae Hungary19A-6 6029697 YP_001695018.1 CDS SPH_1738 NC_010380.1 1599990 1600604 R identified by match to protein family HMM PF03596; match to protein family HMM TIGR00779; CadD complement(1599990..1600604) Streptococcus pneumoniae Hungary19A-6 6029372 YP_001695019.1 CDS rpsO NC_010380.1 1601420 1601689 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(1601420..1601689) Streptococcus pneumoniae Hungary19A-6 6029575 YP_001695020.1 CDS SPH_1740 NC_010380.1 1601830 1602459 R hypothetical protein complement(1601830..1602459) Streptococcus pneumoniae Hungary19A-6 6029061 YP_001695021.1 CDS SPH_1741 NC_010380.1 1603318 1603641 D hypothetical protein 1603318..1603641 Streptococcus pneumoniae Hungary19A-6 6028567 YP_001695022.1 CDS thrS NC_010380.1 1603699 1605642 D catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1603699..1605642 Streptococcus pneumoniae Hungary19A-6 6027692 YP_001695023.1 CDS SPH_1743 NC_010380.1 1605691 1606665 R identified by match to protein family HMM PF02518; histidine kinase complement(1605691..1606665) Streptococcus pneumoniae Hungary19A-6 6029393 YP_001695024.1 CDS SPH_1744 NC_010380.1 1606658 1607335 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator complement(1606658..1607335) Streptococcus pneumoniae Hungary19A-6 6029916 YP_001695025.1 CDS SPH_1745 NC_010380.1 1607491 1608564 D hypothetical protein 1607491..1608564 Streptococcus pneumoniae Hungary19A-6 6028398 YP_001695026.1 CDS SPH_1746 NC_010380.1 1608655 1608957 R hypothetical protein complement(1608655..1608957) Streptococcus pneumoniae Hungary19A-6 6027934 YP_001695027.1 CDS SPH_1747 NC_010380.1 1609025 1609462 R identified by match to protein family HMM PF02082; Rrf2 family protein complement(1609025..1609462) Streptococcus pneumoniae Hungary19A-6 6028820 YP_001695028.1 CDS SPH_1749 NC_010380.1 1610492 1611142 D identified by match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF02742; match to protein family HMM PF04023; iron-dependent transcriptional regulator 1610492..1611142 Streptococcus pneumoniae Hungary19A-6 6029384 YP_001695029.1 CDS dtd NC_010380.1 1611759 1612202 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(1611759..1612202) Streptococcus pneumoniae Hungary19A-6 6029898 YP_001695030.1 CDS spoT NC_010380.1 1612232 1614454 R identified by match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691; guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase complement(1612232..1614454) Streptococcus pneumoniae Hungary19A-6 6027945 YP_001695031.1 CDS SPH_1755 NC_010380.1 1615470 1616099 D identified by match to protein family HMM PF00753; metallo-beta-lactamase superfamily protein 1615470..1616099 Streptococcus pneumoniae Hungary19A-6 6028917 YP_001695032.1 CDS SPH_1756 NC_010380.1 1616222 1618114 R identified by match to protein family HMM PF01431; match to protein family HMM PF05649; endopeptidase O complement(1616222..1618114) Streptococcus pneumoniae Hungary19A-6 6029552 YP_001695033.1 CDS SPH_1757 NC_010380.1 1618405 1619127 D identified by match to protein family HMM PF00005; manganese transport system ATP-binding protein MntA 1618405..1619127 Streptococcus pneumoniae Hungary19A-6 6028858 YP_001695034.1 CDS SPH_1758 NC_010380.1 1619124 1619972 D identified by match to protein family HMM PF00950; manganese transport system membrane protein MntB 1619124..1619972 Streptococcus pneumoniae Hungary19A-6 6028013 YP_001695035.1 CDS SPH_1759 NC_010380.1 1620004 1620933 D identified by match to protein family HMM PF01297; manganese ABC transporter substrate-binding lipoprotein (adhesin B) (Saliva-binding protein) 1620004..1620933 Streptococcus pneumoniae Hungary19A-6 6028900 YP_001695036.1 CDS tpx NC_010380.1 1621056 1621547 D antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1621056..1621547 Streptococcus pneumoniae Hungary19A-6 6029042 YP_001695037.1 CDS SPH_1761 NC_010380.1 1621643 1624351 R identified by match to protein family HMM PF02687; ABC transporter permease complement(1621643..1624351) Streptococcus pneumoniae Hungary19A-6 6029275 YP_001695038.1 CDS SPH_1762 NC_010380.1 1624353 1625054 R identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease MacB complement(1624353..1625054) Streptococcus pneumoniae Hungary19A-6 6029408 YP_001695039.1 CDS gpmA NC_010380.1 1627767 1628459 R phosphoglyceromutase; pgam; bpg-dependent pgam; dpgm; 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(1627767..1628459) Streptococcus pneumoniae Hungary19A-6 6027737 YP_001695040.1 CDS ileS NC_010380.1 1629780 1632572 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase complement(1629780..1632572) Streptococcus pneumoniae Hungary19A-6 6027767 YP_001695041.1 CDS SPH_1768 NC_010380.1 1632825 1632941 R hypothetical protein complement(1632825..1632941) Streptococcus pneumoniae Hungary19A-6 6027957 YP_001695042.1 CDS SPH_1769 NC_010380.1 1632920 1633708 R identified by match to protein family HMM PF05103; cell-division initiation protein complement(1632920..1633708) Streptococcus pneumoniae Hungary19A-6 6029380 YP_001695043.1 CDS SPH_1770 NC_010380.1 1633717 1634502 R identified by match to protein family HMM PF01479; hypothetical protein complement(1633717..1634502) Streptococcus pneumoniae Hungary19A-6 6028029 YP_001695044.1 CDS SPH_1771 NC_010380.1 1634499 1634762 R identified by match to protein family HMM PF02325; hypothetical protein complement(1634499..1634762) Streptococcus pneumoniae Hungary19A-6 6029505 YP_001695045.1 CDS SPH_1772 NC_010380.1 1634762 1635301 R identified by match to protein family HMM PF04472; hypothetical protein complement(1634762..1635301) Streptococcus pneumoniae Hungary19A-6 6029966 YP_001695046.1 CDS SPH_1773 NC_010380.1 1635311 1635982 R identified by match to protein family HMM TIGR00044; YggS family pyridoxal phosphate protein complement(1635311..1635982) Streptococcus pneumoniae Hungary19A-6 6029106 YP_001695047.1 CDS ftsZ NC_010380.1 1635987 1637246 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(1635987..1637246) Streptococcus pneumoniae Hungary19A-6 6028790 YP_001695048.1 CDS ftsA NC_010380.1 1637263 1638636 R identified by match to protein family HMM PF02491; match to protein family HMM TIGR01174; cell division protein FtsA complement(1637263..1638636) Streptococcus pneumoniae Hungary19A-6 6029164 YP_001695049.1 CDS SPH_1776 NC_010380.1 1638855 1639559 R identified by match to protein family HMM TIGR02206; hypothetical protein complement(1638855..1639559) Streptococcus pneumoniae Hungary19A-6 6028174 YP_001695050.1 CDS SPH_1777 NC_010380.1 1639650 1640261 R identified by match to protein family HMM PF00293; hypothetical protein complement(1639650..1640261) Streptococcus pneumoniae Hungary19A-6 6029843 YP_001695051.1 CDS SPH_1778 NC_010380.1 1640248 1641621 R identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01143; UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D- alanyl-D-alanine ligase complement(1640248..1641621) Streptococcus pneumoniae Hungary19A-6 6029837 YP_001695052.1 CDS ddl NC_010380.1 1641706 1642749 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(1641706..1642749) Streptococcus pneumoniae Hungary19A-6 6027870 YP_001695053.1 CDS recR NC_010380.1 1642926 1643522 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(1642926..1643522) Streptococcus pneumoniae Hungary19A-6 6028479 YP_001695054.1 CDS SPH_1781 NC_010380.1 1643533 1645575 R identified by match to protein family HMM PF00905; match to protein family HMM PF03717; penicillin-binding protein 2B complement(1643533..1645575) Streptococcus pneumoniae Hungary19A-6 6029235 YP_001695055.1 CDS SPH_1782 NC_010380.1 1645790 1646641 D identified by match to protein family HMM PF01380; match to protein family HMM PF01418; RpiR family transcriptional regulator 1645790..1646641 Streptococcus pneumoniae Hungary19A-6 6029860 YP_001695056.1 CDS SPH_1783 NC_010380.1 1646657 1647541 R identified by match to protein family HMM PF00480; glucokinase complement(1646657..1647541) Streptococcus pneumoniae Hungary19A-6 6028699 YP_001695057.1 CDS SPH_1784 NC_010380.1 1647559 1648476 R identified by match to protein family HMM PF00701; N-acetylneuraminate lyase complement(1647559..1648476) Streptococcus pneumoniae Hungary19A-6 6029425 YP_001695058.1 CDS SPH_1785 NC_010380.1 1648645 1649289 R identified by match to protein family HMM PF04854; hypothetical protein complement(1648645..1649289) Streptococcus pneumoniae Hungary19A-6 6028367 YP_001695059.1 CDS SPH_1786 NC_010380.1 1649566 1649874 R hypothetical protein complement(1649566..1649874) Streptococcus pneumoniae Hungary19A-6 6028007 YP_001695060.1 CDS SPH_1787 NC_010380.1 1650007 1650459 R identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein complement(1650007..1650459) Streptococcus pneumoniae Hungary19A-6 6028312 YP_001695061.1 CDS SPH_1788 NC_010380.1 1650686 1651525 R identified by match to protein family HMM PF00528; ABC transporter membrane-spanning permease - sugar transport complement(1650686..1651525) Streptococcus pneumoniae Hungary19A-6 6027921 YP_001695062.1 CDS SPH_1789 NC_010380.1 1651541 1652428 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1651541..1652428) Streptococcus pneumoniae Hungary19A-6 6028625 YP_001695063.1 CDS SPH_1790 NC_010380.1 1652659 1653987 R identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein - sugar transport complement(1652659..1653987) Streptococcus pneumoniae Hungary19A-6 6028073 YP_001695064.1 CDS SPH_1791 NC_010380.1 1654102 1654800 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(1654102..1654800) Streptococcus pneumoniae Hungary19A-6 6029905 YP_001695065.1 CDS SPH_1792 NC_010380.1 1654980 1656083 R identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; match to protein family HMM PF03447; oxidoreductase YjhC complement(1654980..1656083) Streptococcus pneumoniae Hungary19A-6 6028318 YP_001695066.1 CDS SPH_1793 NC_010380.1 1656125 1656958 R identified by match to protein family HMM PF00528; ABC transporter membrane-spanning permease - sugar transport complement(1656125..1656958) Streptococcus pneumoniae Hungary19A-6 6027801 YP_001695067.1 CDS SPH_1794 NC_010380.1 1656958 1657842 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1656958..1657842) Streptococcus pneumoniae Hungary19A-6 6029254 YP_001695068.1 CDS SPH_1795 NC_010380.1 1657921 1659258 R identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein - sugar transport complement(1657921..1659258) Streptococcus pneumoniae Hungary19A-6 6029078 YP_001695069.1 CDS SPH_1796 NC_010380.1 1659277 1659729 R identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein complement(1659277..1659729) Streptococcus pneumoniae Hungary19A-6 6029228 YP_001695070.1 CDS SPH_1797 NC_010380.1 1660744 1663572 R identified by match to protein family HMM PF02012; match to protein family HMM PF02973; match to protein family HMM TIGR01167; neuraminidase complement(1660744..1663572) Streptococcus pneumoniae Hungary19A-6 6029020 YP_001695071.1 CDS SPH_1798 NC_010380.1 1663929 1664156 R hypothetical protein complement(1663929..1664156) Streptococcus pneumoniae Hungary19A-6 6028615 YP_001695072.1 CDS SPH_1800 NC_010380.1 1665141 1666121 R identified by match to protein family HMM PF05448; xylan esterase 1 complement(1665141..1666121) Streptococcus pneumoniae Hungary19A-6 6029661 YP_001695073.1 CDS recG NC_010380.1 1666438 1668453 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(1666438..1668453) Streptococcus pneumoniae Hungary19A-6 6027865 YP_001695074.1 CDS alr NC_010380.1 1668472 1669575 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(1668472..1669575) Streptococcus pneumoniae Hungary19A-6 6029713 YP_001695075.1 CDS acpS NC_010380.1 1669565 1669927 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(1669565..1669927) Streptococcus pneumoniae Hungary19A-6 6028688 YP_001695076.1 CDS SPH_1804 NC_010380.1 1669972 1671003 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1669972..1671003) Streptococcus pneumoniae Hungary19A-6 6028139 YP_001695077.1 CDS SPH_1805 NC_010380.1 1671005 1672036 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1671005..1672036) Streptococcus pneumoniae Hungary19A-6 6029611 YP_001695078.1 CDS secA NC_010380.1 1672117 1674630 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(1672117..1674630) Streptococcus pneumoniae Hungary19A-6 6028235 YP_001695079.1 CDS SPH_1807 NC_010380.1 1674776 1675063 R hypothetical protein complement(1674776..1675063) Streptococcus pneumoniae Hungary19A-6 6028559 YP_001695080.1 CDS SPH_1808 NC_010380.1 1675074 1675724 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1675074..1675724) Streptococcus pneumoniae Hungary19A-6 6029627 YP_001695081.1 CDS SPH_1809 NC_010380.1 1675728 1676369 R hypothetical protein complement(1675728..1676369) Streptococcus pneumoniae Hungary19A-6 6029722 YP_001695082.1 CDS SPH_1810 NC_010380.1 1676362 1677153 R hypothetical protein complement(1676362..1677153) Streptococcus pneumoniae Hungary19A-6 6029292 YP_001695083.1 CDS SPH_1815 NC_010380.1 1678985 1679335 R hypothetical protein complement(1678985..1679335) Streptococcus pneumoniae Hungary19A-6 6029440 YP_001695084.1 CDS SPH_1816 NC_010380.1 1679475 1679819 R identified by glimmer; hypothetical protein complement(1679475..1679819) Streptococcus pneumoniae Hungary19A-6 6028168 YP_001695085.1 CDS engA NC_010380.1 1679901 1681211 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(1679901..1681211) Streptococcus pneumoniae Hungary19A-6 6027793 YP_001695086.1 CDS SPH_1818 NC_010380.1 1681225 1681938 R identified by match to protein family HMM PF00881; nitroreductase complement(1681225..1681938) Streptococcus pneumoniae Hungary19A-6 6030057 YP_001695087.1 CDS SPH_1819 NC_010380.1 1681935 1682831 R Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI complement(1681935..1682831) Streptococcus pneumoniae Hungary19A-6 6029963 YP_001695088.1 CDS SPH_1820 NC_010380.1 1682832 1684001 R identified by match to protein family HMM PF07261; replication initiation and membrane attachment protein complement(1682832..1684001) Streptococcus pneumoniae Hungary19A-6 6029359 YP_001695089.1 CDS nrdR NC_010380.1 1684002 1684475 R identified by match to protein family HMM PF03477; match to protein family HMM TIGR00244; transcriptional regulator NrdR complement(1684002..1684475) Streptococcus pneumoniae Hungary19A-6 6027766 YP_001695090.1 CDS SPH_1822 NC_010380.1 1684615 1684980 D identified by match to protein family HMM PF00392; GntR family transcriptional regulator 1684615..1684980 Streptococcus pneumoniae Hungary19A-6 6028047 YP_001695091.1 CDS SPH_1823 NC_010380.1 1684985 1685680 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1684985..1685680 Streptococcus pneumoniae Hungary19A-6 6028633 YP_001695092.1 CDS SPH_1824 NC_010380.1 1685697 1686464 D ABC transporter ATP-binding protein 1685697..1686464 Streptococcus pneumoniae Hungary19A-6 6027840 YP_001695093.1 CDS SPH_1825 NC_010380.1 1686817 1688016 R ABC transporter membrane-spanning permease - Na+ export complement(1686817..1688016) Streptococcus pneumoniae Hungary19A-6 6028159 YP_001695094.1 CDS SPH_1826 NC_010380.1 1688013 1688906 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein - Na+ export complement(1688013..1688906) Streptococcus pneumoniae Hungary19A-6 6028056 YP_001695095.1 CDS SPH_1827 NC_010380.1 1689029 1689220 D chlorohydrolase 1689029..1689220 Streptococcus pneumoniae Hungary19A-6 6027707 YP_001695096.1 CDS SPH_1828 NC_010380.1 1690216 1690833 D identified by match to protein family HMM PF09335; SNARE associated Golgi protein 1690216..1690833 Streptococcus pneumoniae Hungary19A-6 6027989 YP_001695097.1 CDS SPH_1829 NC_010380.1 1691153 1692040 R identified by match to protein family HMM PF00480; fructokinase complement(1691153..1692040) Streptococcus pneumoniae Hungary19A-6 6029019 YP_001695098.1 CDS SPH_1830 NC_010380.1 1692189 1694072 R identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01996; pts system, sucrose-specific IIBC component complement(1692189..1694072) Streptococcus pneumoniae Hungary19A-6 6029178 YP_001695099.1 CDS SPH_1831 NC_010380.1 1694199 1694396 R hypothetical protein complement(1694199..1694396) Streptococcus pneumoniae Hungary19A-6 6028093 YP_001695100.1 CDS SPH_1832 NC_010380.1 1694449 1695903 D identified by match to protein family HMM PF00251; match to protein family HMM PF08244; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase (Sucrase) (invertase) 1694449..1695903 Streptococcus pneumoniae Hungary19A-6 6029301 YP_001695101.1 CDS SPH_1835 NC_010380.1 1696883 1698157 R identified by match to protein family HMM TIGR00532; hydroxymethylglutaryl-CoA reductase, degradative complement(1696883..1698157) Streptococcus pneumoniae Hungary19A-6 6028622 YP_001695102.1 CDS SPH_1836 NC_010380.1 1698157 1699353 R identified by match to protein family HMM PF01154; match to protein family HMM PF08540; match to protein family HMM TIGR01835; hydroxymethylglutaryl-CoA synthase complement(1698157..1699353) Streptococcus pneumoniae Hungary19A-6 6029876 YP_001695103.1 CDS SPH_1837 NC_010380.1 1699460 1699657 R hypothetical protein complement(1699460..1699657) Streptococcus pneumoniae Hungary19A-6 6028102 YP_001695104.1 CDS SPH_1838 NC_010380.1 1699776 1700165 R identified by match to protein family HMM PF01609; IS4 family transposase complement(1699776..1700165) Streptococcus pneumoniae Hungary19A-6 6027781 YP_001695105.1 CDS SPH_1839 NC_010380.1 1700464 1700913 R hypothetical protein complement(1700464..1700913) Streptococcus pneumoniae Hungary19A-6 6027999 YP_001695106.1 CDS SPH_1840 NC_010380.1 1700915 1701673 R identified by match to protein family HMM PF06738; hypothetical protein complement(1700915..1701673) Streptococcus pneumoniae Hungary19A-6 6029612 YP_001695107.1 CDS SPH_1841 NC_010380.1 1701788 1703767 R identified by match to protein family HMM PF00069; match to protein family HMM PF01163; match to protein family HMM PF03793; Stk1 complement(1701788..1703767) Streptococcus pneumoniae Hungary19A-6 6027911 YP_001695108.1 CDS SPH_1842 NC_010380.1 1703764 1704504 R identified by match to protein family HMM PF00481; protein phosphatase PrpC complement(1703764..1704504) Streptococcus pneumoniae Hungary19A-6 6027979 YP_001695109.1 CDS sun NC_010380.1 1704519 1705832 R identified by match to protein family HMM PF01029; match to protein family HMM PF01189; match to protein family HMM TIGR00563; ribosomal RNA small subunit methyltransferase B complement(1704519..1705832) Streptococcus pneumoniae Hungary19A-6 6029341 YP_001695110.1 CDS fmt NC_010380.1 1705825 1706760 R modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase complement(1705825..1706760) Streptococcus pneumoniae Hungary19A-6 6029530 YP_001695111.1 CDS SPH_1845 NC_010380.1 1706773 1709169 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(1706773..1709169) Streptococcus pneumoniae Hungary19A-6 6028751 YP_001695112.1 CDS rpoZ NC_010380.1 1709235 1709549 R Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(1709235..1709549) Streptococcus pneumoniae Hungary19A-6 6028306 YP_001695113.1 CDS gmk NC_010380.1 1709574 1710200 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(1709574..1710200) Streptococcus pneumoniae Hungary19A-6 6028547 YP_001695114.1 CDS SPH_1848 NC_010380.1 1710330 1711943 R identified by match to protein family HMM PF00013; match to protein family HMM PF01966; match to protein family HMM TIGR00277; match to protein family HMM TIGR03319; hypothetical protein complement(1710330..1711943) Streptococcus pneumoniae Hungary19A-6 6029141 YP_001695115.1 CDS SPH_1849 NC_010380.1 1712134 1712388 R identified by match to protein family HMM PF06769; match to protein family HMM TIGR02116; addiction module antitoxin complement(1712134..1712388) Streptococcus pneumoniae Hungary19A-6 6030034 YP_001695116.1 CDS SPH_1850 NC_010380.1 1712392 1712646 R identified by match to protein family HMM PF02604; match to protein family HMM TIGR01552; prevent-host-death family protein complement(1712392..1712646) Streptococcus pneumoniae Hungary19A-6 6028504 YP_001695117.1 CDS SPH_1851 NC_010380.1 1712884 1713981 R identified by match to protein family HMM PF05636; hypothetical protein complement(1712884..1713981) Streptococcus pneumoniae Hungary19A-6 6028645 YP_001695118.1 CDS SPH_1852 NC_010380.1 1713991 1714731 R identified by match to protein family HMM PF08241; match to protein family HMM PF08242; SAM-dependent methyltransferase complement(1713991..1714731) Streptococcus pneumoniae Hungary19A-6 6028445 YP_001695119.1 CDS SPH_1853 NC_010380.1 1715051 1715404 R identified by match to protein family HMM PF02410; match to protein family HMM TIGR00090; iojap-like protein complement(1715051..1715404) Streptococcus pneumoniae Hungary19A-6 6028683 YP_001695120.1 CDS SPH_1854 NC_010380.1 1715417 1715917 R identified by match to protein family HMM PF00857; isochorismatase complement(1715417..1715917) Streptococcus pneumoniae Hungary19A-6 6029502 YP_001695121.1 CDS SPH_1855 NC_010380.1 1715918 1716511 R identified by match to protein family HMM PF01966; match to protein family HMM TIGR00488; hypothetical protein complement(1715918..1716511) Streptococcus pneumoniae Hungary19A-6 6029687 YP_001695122.1 CDS nadD NC_010380.1 1716511 1717140 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(1716511..1717140) Streptococcus pneumoniae Hungary19A-6 6029258 YP_001695123.1 CDS SPH_1857 NC_010380.1 1717192 1717503 R identified by match to protein family HMM PF01985; match to protein family HMM TIGR00253; hypothetical protein complement(1717192..1717503) Streptococcus pneumoniae Hungary19A-6 6029672 YP_001695124.1 CDS SPH_1858 NC_010380.1 1717703 1718809 R in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH complement(1717703..1718809) Streptococcus pneumoniae Hungary19A-6 6030086 YP_001695125.1 CDS yqeG NC_010380.1 1718812 1719339 R identified by match to protein family HMM TIGR01662; match to protein family HMM TIGR01668; HAD family phosphatase complement(1718812..1719339) Streptococcus pneumoniae Hungary19A-6 6028793 YP_001695126.1 CDS SPH_1860 NC_010380.1 1719354 1720262 R identified by match to protein family HMM PF01544; CorA - magnesium and cobalt transporter complement(1719354..1720262) Streptococcus pneumoniae Hungary19A-6 6028442 YP_001695127.1 CDS SPH_1861 NC_010380.1 1720319 1720879 R identified by match to protein family HMM PF00924; small conductance mechanosensitive ion channel complement(1720319..1720879) Streptococcus pneumoniae Hungary19A-6 6028585 YP_001695128.1 CDS SPH_1864 NC_010380.1 1722294 1723247 D identified by match to protein family HMM PF06081; hypothetical protein 1722294..1723247 Streptococcus pneumoniae Hungary19A-6 6028952 YP_001695129.1 CDS SPH_1865 NC_010380.1 1723270 1723467 R chlorohydrolase complement(1723270..1723467) Streptococcus pneumoniae Hungary19A-6 6029404 YP_001695130.1 CDS SPH_1866 NC_010380.1 1723528 1723752 R hypothetical protein complement(1723528..1723752) Streptococcus pneumoniae Hungary19A-6 6029493 YP_001695131.1 CDS SPH_1867 NC_010380.1 1723757 1723936 R hypothetical protein complement(1723757..1723936) Streptococcus pneumoniae Hungary19A-6 6028978 YP_001695132.1 CDS SPH_1868 NC_010380.1 1723938 1725275 R identified by match to protein family HMM TIGR02919; hypothetical protein complement(1723938..1725275) Streptococcus pneumoniae Hungary19A-6 6028684 YP_001695133.1 CDS SPH_1869 NC_010380.1 1725268 1726779 R identified by match to protein family HMM PF00534; match to protein family HMM PF09318; match to protein family HMM TIGR02918; hypothetical protein complement(1725268..1726779) Streptococcus pneumoniae Hungary19A-6 6029538 YP_001695134.1 CDS SPH_1870 NC_010380.1 1726791 1729163 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins; preprotein translocase subunit SecA complement(1726791..1729163) Streptococcus pneumoniae Hungary19A-6 6027742 YP_001695135.1 CDS SPH_1871 NC_010380.1 1729156 1729596 R accessory secretory protein Asp3 complement(1729156..1729596) Streptococcus pneumoniae Hungary19A-6 6028897 YP_001695136.1 CDS SPH_1872 NC_010380.1 1729593 1731128 R accessory secretory protein Asp2 complement(1729593..1731128) Streptococcus pneumoniae Hungary19A-6 6029304 YP_001695137.1 CDS SPH_1873 NC_010380.1 1731112 1732692 R accessory secretory protein Asp1 complement(1731112..1732692) Streptococcus pneumoniae Hungary19A-6 6028096 YP_001695138.1 CDS secY NC_010380.1 1732702 1733919 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(1732702..1733919) Streptococcus pneumoniae Hungary19A-6 6029474 YP_001695139.1 CDS SPH_1875 NC_010380.1 1733976 1734881 R identified by match to protein family HMM PF00535; glycosyl transferase complement(1733976..1734881) Streptococcus pneumoniae Hungary19A-6 6029177 YP_001695140.1 CDS SPH_1876 NC_010380.1 1734881 1736077 R identified by match to protein family HMM PF01501; glycosyl transferase complement(1734881..1736077) Streptococcus pneumoniae Hungary19A-6 6028303 YP_001695141.1 CDS SPH_1877 NC_010380.1 1736086 1737306 R identified by match to protein family HMM PF01501; glycosyl transferase complement(1736086..1737306) Streptococcus pneumoniae Hungary19A-6 6028009 YP_001695142.1 CDS SPH_1878 NC_010380.1 1737331 1738215 R identified by match to protein family HMM PF00535; glycosyl transferase complement(1737331..1738215) Streptococcus pneumoniae Hungary19A-6 6028710 YP_001695143.1 CDS SPH_1879 NC_010380.1 1738212 1740665 R identified by match to protein family HMM PF01501; match to protein family HMM PF08759; glycosyl transferase complement(1738212..1740665) Streptococcus pneumoniae Hungary19A-6 6028256 YP_001695144.1 CDS SPH_1880 NC_010380.1 1740675 1741685 R hypothetical protein complement(1740675..1741685) Streptococcus pneumoniae Hungary19A-6 6028690 YP_001695145.1 CDS SPH_1882 NC_010380.1 1742630 1743508 R identified by match to protein family HMM PF00132; exopolysaccharide biosynthesis protein, acetyltransferase complement(1742630..1743508) Streptococcus pneumoniae Hungary19A-6 6027799 YP_001695146.1 CDS SPH_1885 NC_010380.1 1745650 1759947 R identified by match to protein family HMM PF00746; match to protein family HMM TIGR01167; cell wall surface anchor family protein complement(1745650..1759947) Streptococcus pneumoniae Hungary19A-6 6029411 YP_001695147.1 CDS SPH_1886 NC_010380.1 1760348 1760608 R Spn1, transposase Orf2 complement(1760348..1760608) Streptococcus pneumoniae Hungary19A-6 6028601 YP_001695148.1 CDS SPH_1890 NC_010380.1 1761668 1761889 D hypothetical protein 1761668..1761889 Streptococcus pneumoniae Hungary19A-6 6029897 YP_001695149.1 CDS trx NC_010380.1 1761906 1762220 D identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin 1761906..1762220 Streptococcus pneumoniae Hungary19A-6 6028070 YP_001695150.1 CDS SPH_1892 NC_010380.1 1762526 1763059 D NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 1762526..1763059 Streptococcus pneumoniae Hungary19A-6 6028707 YP_001695151.1 CDS SPH_1893 NC_010380.1 1763071 1763514 D hypothetical protein 1763071..1763514 Streptococcus pneumoniae Hungary19A-6 6028840 YP_001695152.1 CDS SPH_1894 NC_010380.1 1763539 1764207 R identified by match to protein family HMM PF00230; aquaporin Z - water channel protein complement(1763539..1764207) Streptococcus pneumoniae Hungary19A-6 6027907 YP_001695153.1 CDS SPH_1895 NC_010380.1 1764318 1764872 R hypothetical protein complement(1764318..1764872) Streptococcus pneumoniae Hungary19A-6 6029639 YP_001695154.1 CDS SPH_1896 NC_010380.1 1764940 1765095 R identified by glimmer; hypothetical protein complement(1764940..1765095) Streptococcus pneumoniae Hungary19A-6 6029116 YP_001695155.1 CDS pepF2 NC_010380.1 1765118 1766914 R identified by match to protein family HMM PF01432; match to protein family HMM PF08439; match to protein family HMM TIGR00181; oligoendopeptidase F complement(1765118..1766914) Streptococcus pneumoniae Hungary19A-6 6029593 YP_001695156.1 CDS SPH_1898 NC_010380.1 1766925 1767668 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(1766925..1767668) Streptococcus pneumoniae Hungary19A-6 6028679 YP_001695157.1 CDS prmA NC_010380.1 1767670 1768620 R methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase complement(1767670..1768620) Streptococcus pneumoniae Hungary19A-6 6029267 YP_001695158.1 CDS SPH_1900 NC_010380.1 1768758 1769186 R identified by match to protein family HMM PF00293; 7,8-dihydro-8-oxoguanine-triphosphatase complement(1768758..1769186) Streptococcus pneumoniae Hungary19A-6 6028976 YP_001695159.1 CDS SPH_1901 NC_010380.1 1769188 1770255 R identified by match to protein family HMM PF02163; peptidase, M50 family protein complement(1769188..1770255) Streptococcus pneumoniae Hungary19A-6 6030041 YP_001695160.1 CDS SPH_1902 NC_010380.1 1770274 1770744 R hypothetical protein complement(1770274..1770744) Streptococcus pneumoniae Hungary19A-6 6027750 YP_001695161.1 CDS SPH_1903 NC_010380.1 1771035 1771487 R identified by match to protein family HMM PF03681; hypothetical protein complement(1771035..1771487) Streptococcus pneumoniae Hungary19A-6 6027791 YP_001695162.1 CDS SPH_1904 NC_010380.1 1771524 1771703 R identified by match to protein family HMM PF07927; hypothetical protein complement(1771524..1771703) Streptococcus pneumoniae Hungary19A-6 6028238 YP_001695163.1 CDS SPH_1905 NC_010380.1 1771840 1772019 R hypothetical protein complement(1771840..1772019) Streptococcus pneumoniae Hungary19A-6 6028768 YP_001695164.1 CDS SPH_1907 NC_010380.1 1772697 1773968 D identified by match to protein family HMM PF00004; recombination factor protein RarA 1772697..1773968 Streptococcus pneumoniae Hungary19A-6 6027725 YP_001695165.1 CDS SPH_1909 NC_010380.1 1774513 1775832 R identified by match to protein family HMM PF00251; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase complement(1774513..1775832) Streptococcus pneumoniae Hungary19A-6 6028779 YP_001695166.1 CDS SPH_1910 NC_010380.1 1775842 1776687 R identified by match to protein family HMM PF00528; ABC transporter membrane-spanning permease - sugar transport complement(1775842..1776687) Streptococcus pneumoniae Hungary19A-6 6029738 YP_001695167.1 CDS SPH_1911 NC_010380.1 1776689 1777591 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1776689..1777591) Streptococcus pneumoniae Hungary19A-6 6029469 YP_001695168.1 CDS SPH_1912 NC_010380.1 1777687 1778997 R identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein - sugar transport complement(1777687..1778997) Streptococcus pneumoniae Hungary19A-6 6028308 YP_001695169.1 CDS SPH_1913 NC_010380.1 1779124 1780119 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sugar-binding transcriptional regulator, LacI family protein complement(1779124..1780119) Streptococcus pneumoniae Hungary19A-6 6029865 YP_001695170.1 CDS SPH_1914 NC_010380.1 1780481 1781962 R identified by match to protein family HMM PF05043; match to protein family HMM PF08270; match to protein family HMM PF08279; match to protein family HMM PF08280; M protein trans-acting positive transcriptional regulator complement(1780481..1781962) Streptococcus pneumoniae Hungary19A-6 6029097 YP_001695171.1 CDS SPH_1916 NC_010380.1 1782653 1783219 D hypothetical protein 1782653..1783219 Streptococcus pneumoniae Hungary19A-6 6029104 YP_001695172.1 CDS SPH_1917 NC_010380.1 1783231 1783401 D lipoprotein 1783231..1783401 Streptococcus pneumoniae Hungary19A-6 6029412 YP_001695173.1 CDS SPH_1918 NC_010380.1 1783440 1784048 D identified by match to protein family HMM PF03780; Gls24 protein 1783440..1784048 Streptococcus pneumoniae Hungary19A-6 6029383 YP_001695174.1 CDS SPH_1919 NC_010380.1 1784079 1784282 D identified by match to protein family HMM PF05532; hypothetical protein 1784079..1784282 Streptococcus pneumoniae Hungary19A-6 6029373 YP_001695175.1 CDS SPH_1920 NC_010380.1 1784392 1784631 R hypothetical protein complement(1784392..1784631) Streptococcus pneumoniae Hungary19A-6 6028065 YP_001695176.1 CDS SPH_1921 NC_010380.1 1785095 1785214 R identified by glimmer; hypothetical protein complement(1785095..1785214) Streptococcus pneumoniae Hungary19A-6 6028239 YP_001695177.1 CDS SPH_1922 NC_010380.1 1785415 1786185 R identified by match to protein family HMM PF01925; hypothetical protein complement(1785415..1786185) Streptococcus pneumoniae Hungary19A-6 6029702 YP_001695178.1 CDS SPH_1923 NC_010380.1 1786200 1787048 R identified by match to protein family HMM PF03781; sulfatase-modifying factor 1 (C-alpha-formyglycine-generating enzyme 1) complement(1786200..1787048) Streptococcus pneumoniae Hungary19A-6 6028244 YP_001695179.1 CDS SPH_1924 NC_010380.1 1787045 1788520 R can hydrolyze p-nitrophenyl sulfate; contains a specific cysteine that is converted into C{alpha]-formylglycine upon activation with the anaerobic sulfatase-maturase; arylsulfatase complement(1787045..1788520) Streptococcus pneumoniae Hungary19A-6 6029582 YP_001695180.1 CDS SPH_1925 NC_010380.1 1788843 1790198 R identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; phosphotransferase system complement(1788843..1790198) Streptococcus pneumoniae Hungary19A-6 6028782 YP_001695181.1 CDS SPH_1926 NC_010380.1 1790208 1790525 R pts system lichenan-specific eiia component; eiia-lic; eiii-lic; identified by match to protein family HMM PF02255; lichenan-specific phosphotransferase enzyme IIA component complement(1790208..1790525) Streptococcus pneumoniae Hungary19A-6 6028534 YP_001695182.1 CDS SPH_1927 NC_010380.1 1790542 1790859 R pts system lichenan-specific eiib component; eiib-lic; identified by match to protein family HMM PF02302; lichenan-specific phosphotransferase enzyme IIB component complement(1790542..1790859) Streptococcus pneumoniae Hungary19A-6 6028292 YP_001695183.1 CDS SPH_1928 NC_010380.1 1790874 1791770 R hypothetical protein complement(1790874..1791770) Streptococcus pneumoniae Hungary19A-6 6027875 YP_001695184.1 CDS SPH_1929 NC_010380.1 1791773 1793035 R pts system lichenan-specific eiiccomponent; eiic-lic; identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; lichenan permease IIC component complement(1791773..1793035) Streptococcus pneumoniae Hungary19A-6 6030026 YP_001695185.1 CDS SPH_1930 NC_010380.1 1793315 1794493 D identified by match to protein family HMM PF00480; ROK family protein 1793315..1794493 Streptococcus pneumoniae Hungary19A-6 6029466 YP_001695186.1 CDS SPH_1931 NC_010380.1 1794721 1795167 R identified by match to protein family HMM PF00583; acetyltransferase complement(1794721..1795167) Streptococcus pneumoniae Hungary19A-6 6028066 YP_001695187.1 CDS SPH_1933 NC_010380.1 1795237 1795896 D identified by match to protein family HMM PF01478; match to protein family HMM PF06750; type 4 prepilin peptidase 1795237..1795896 Streptococcus pneumoniae Hungary19A-6 6028111 YP_001695188.1 CDS trpA NC_010380.1 1795868 1796644 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1795868..1796644) Streptococcus pneumoniae Hungary19A-6 6027807 YP_001695189.1 CDS trpB NC_010380.1 1796637 1797860 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1796637..1797860) Streptococcus pneumoniae Hungary19A-6 6029922 YP_001695190.1 CDS trpF NC_010380.1 1797838 1798437 R catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase complement(1797838..1798437) Streptococcus pneumoniae Hungary19A-6 6029198 YP_001695191.1 CDS trpC NC_010380.1 1798424 1799191 R involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol phosphate synthase complement(1798424..1799191) Streptococcus pneumoniae Hungary19A-6 6029278 YP_001695192.1 CDS trpD NC_010380.1 1799188 1800192 R Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase complement(1799188..1800192) Streptococcus pneumoniae Hungary19A-6 6028781 YP_001695193.1 CDS SPH_1938 NC_010380.1 1800203 1800769 R TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II complement(1800203..1800769) Streptococcus pneumoniae Hungary19A-6 6028794 YP_001695194.1 CDS trpE NC_010380.1 1800766 1802127 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1800766..1802127) Streptococcus pneumoniae Hungary19A-6 6028675 YP_001695195.1 CDS SPH_1940 NC_010380.1 1802499 1802750 R chlorohydrolase complement(1802499..1802750) Streptococcus pneumoniae Hungary19A-6 6029628 YP_001695196.1 CDS SPH_1941 NC_010380.1 1803358 1804359 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; catabolite control protein complement(1803358..1804359) Streptococcus pneumoniae Hungary19A-6 6027939 YP_001695197.1 CDS SPH_1942 NC_010380.1 1804644 1804835 R hypothetical protein complement(1804644..1804835) Streptococcus pneumoniae Hungary19A-6 6029256 YP_001695198.1 CDS SPH_1943 NC_010380.1 1804931 1805641 R identified by match to protein family HMM PF02308; Mg2+ transporter-C (MgtC) family protein complement(1804931..1805641) Streptococcus pneumoniae Hungary19A-6 6029836 YP_001695199.1 CDS SPH_1944 NC_010380.1 1805644 1807335 R identified by match to protein family HMM PF00528; binding-protein-dependent transport systems inner membrane component complement(1805644..1807335) Streptococcus pneumoniae Hungary19A-6 6027896 YP_001695200.1 CDS SPH_1945 NC_010380.1 1807347 1808357 R identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; spermidine/putrescine import ATP-binding protein PotA complement(1807347..1808357) Streptococcus pneumoniae Hungary19A-6 6028715 YP_001695201.1 CDS SPH_1946 NC_010380.1 1808460 1809527 R ABC transporter substrate-binding protein complement(1808460..1809527) Streptococcus pneumoniae Hungary19A-6 6028022 YP_001695202.1 CDS SPH_1947 NC_010380.1 1809552 1810211 R identified by match to protein family HMM PF08975; hypothetical protein complement(1809552..1810211) Streptococcus pneumoniae Hungary19A-6 6028346 YP_001695203.1 CDS SPH_1948 NC_010380.1 1810339 1810452 R hypothetical protein complement(1810339..1810452) Streptococcus pneumoniae Hungary19A-6 6029295 YP_001695204.1 CDS SPH_1949 NC_010380.1 1810955 1811251 R hypothetical protein complement(1810955..1811251) Streptococcus pneumoniae Hungary19A-6 6027826 YP_001695205.1 CDS SPH_1950 NC_010380.1 1811235 1813361 R identified by match to protein family HMM PF04650; match to protein family HMM TIGR01168; cell wall surface anchor family protein complement(1811235..1813361) Streptococcus pneumoniae Hungary19A-6 6028736 YP_001695206.1 CDS SPH_1951 NC_010380.1 1814115 1814240 R hypothetical protein complement(1814115..1814240) Streptococcus pneumoniae Hungary19A-6 6027871 YP_001695207.1 CDS SPH_1952 NC_010380.1 1814524 1815750 R identified by match to protein family HMM PF01041; Cps7G complement(1814524..1815750) Streptococcus pneumoniae Hungary19A-6 6027709 YP_001695208.1 CDS SPH_1953 NC_010380.1 1815793 1816485 R identified by match to protein family HMM PF02397; sugar transferase complement(1815793..1816485) Streptococcus pneumoniae Hungary19A-6 6029152 YP_001695209.1 CDS SPH_1954 NC_010380.1 1816658 1818409 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein complement(1816658..1818409) Streptococcus pneumoniae Hungary19A-6 6029369 YP_001695210.1 CDS SPH_1955 NC_010380.1 1818399 1820144 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein complement(1818399..1820144) Streptococcus pneumoniae Hungary19A-6 6029485 YP_001695211.1 CDS SPH_1956 NC_010380.1 1820350 1820802 R identified by match to protein family HMM PF04239; hypothetical protein complement(1820350..1820802) Streptococcus pneumoniae Hungary19A-6 6029751 YP_001695212.1 CDS xth NC_010380.1 1821389 1822216 D identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633; exodeoxyribonuclease III 1821389..1822216 Streptococcus pneumoniae Hungary19A-6 6029358 YP_001695213.1 CDS xpt NC_010380.1 1823492 1824073 D Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 1823492..1824073 Streptococcus pneumoniae Hungary19A-6 6028488 YP_001695214.1 CDS SPH_1963 NC_010380.1 1824073 1825335 D identified by match to protein family HMM PF00860; match to protein family HMM PF00916; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173; xanthine permease 1824073..1825335 Streptococcus pneumoniae Hungary19A-6 6028469 YP_001695215.1 CDS SPH_1964 NC_010380.1 1825422 1826288 R identified by match to protein family HMM PF04556; type II restriction enzyme DpnII complement(1825422..1826288) Streptococcus pneumoniae Hungary19A-6 6029545 YP_001695216.1 CDS SPH_1965 NC_010380.1 1826275 1827045 R identified by match to protein family HMM PF01555; DNA methylase complement(1826275..1827045) Streptococcus pneumoniae Hungary19A-6 6028280 YP_001695217.1 CDS SPH_1966 NC_010380.1 1827071 1827925 R identified by match to protein family HMM PF02086; match to protein family HMM TIGR00571; modification methylase DpnIIA complement(1827071..1827925) Streptococcus pneumoniae Hungary19A-6 6029480 YP_001695218.1 CDS SPH_1967 NC_010380.1 1828082 1828486 R identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; thioesterase complement(1828082..1828486) Streptococcus pneumoniae Hungary19A-6 6029327 YP_001695219.1 CDS galT NC_010380.1 1828556 1830037 R catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase complement(1828556..1830037) Streptococcus pneumoniae Hungary19A-6 6028304 YP_001695220.1 CDS galK NC_010380.1 1830056 1831234 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(1830056..1831234) Streptococcus pneumoniae Hungary19A-6 6027916 YP_001695221.1 CDS SPH_1970 NC_010380.1 1831399 1832406 D member of GalR-LacI family of transcriptional regulators, binds DNA; regulator of gal operon; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; GalR 1831399..1832406 Streptococcus pneumoniae Hungary19A-6 6029248 YP_001695222.1 CDS SPH_1971 NC_010380.1 1832452 1833489 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; alcohol dehydrogenase complement(1832452..1833489) Streptococcus pneumoniae Hungary19A-6 6027703 YP_001695223.1 CDS SPH_1972 NC_010380.1 1833490 1833843 R identified by match to protein family HMM PF00376; MerR family transcriptional regulator complement(1833490..1833843) Streptococcus pneumoniae Hungary19A-6 6029305 YP_001695224.1 CDS SPH_1973 NC_010380.1 1834087 1834977 R identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation diffusion facilitator transporter - heavy metal transport complement(1834087..1834977) Streptococcus pneumoniae Hungary19A-6 6029073 YP_001695225.1 CDS SPH_1974 NC_010380.1 1835110 1835646 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 1835110..1835646 Streptococcus pneumoniae Hungary19A-6 6029877 YP_001695226.1 CDS SPH_1975 NC_010380.1 1835813 1836619 R identified by match to protein family HMM PF04973; match to protein family HMM TIGR01528; nicotinamide mononucleotide transporter complement(1835813..1836619) Streptococcus pneumoniae Hungary19A-6 6027697 YP_001695227.1 CDS SPH_1976 NC_010380.1 1836790 1836906 R identified by glimmer; hypothetical protein complement(1836790..1836906) Streptococcus pneumoniae Hungary19A-6 6029193 YP_001695228.1 CDS SPH_1977 NC_010380.1 1836964 1838484 R identified by match to protein family HMM PF00528; match to protein family HMM PF04069; choline transporter complement(1836964..1838484) Streptococcus pneumoniae Hungary19A-6 6028290 YP_001695229.1 CDS SPH_1978 NC_010380.1 1838477 1839205 R identified by match to protein family HMM PF00005; choline transport ATP-binding protein opuBA complement(1838477..1839205) Streptococcus pneumoniae Hungary19A-6 6028646 YP_001695230.1 CDS SPH_1979 NC_010380.1 1839220 1839984 R identified by match to protein family HMM PF07366; hypothetical protein complement(1839220..1839984) Streptococcus pneumoniae Hungary19A-6 6028803 YP_001695231.1 CDS SPH_1980 NC_010380.1 1839988 1840431 R identified by match to protein family HMM PF01047; MarR family transcriptional regulator complement(1839988..1840431) Streptococcus pneumoniae Hungary19A-6 6029363 YP_001695232.1 CDS SPH_1981 NC_010380.1 1841108 1841404 R hypothetical protein complement(1841108..1841404) Streptococcus pneumoniae Hungary19A-6 6029525 YP_001695233.1 CDS pepA NC_010380.1 1841426 1842490 R identified by match to protein family HMM PF05343; match to protein family HMM TIGR03107; glutamyl aminopeptidase complement(1841426..1842490) Streptococcus pneumoniae Hungary19A-6 6029928 YP_001695234.1 CDS SPH_1983 NC_010380.1 1842610 1842732 D hypothetical protein 1842610..1842732 Streptococcus pneumoniae Hungary19A-6 6029040 YP_001695235.1 CDS SPH_1985 NC_010380.1 1844015 1844974 D identified by match to protein family HMM PF01032; ABC transporter membrane-spanning permease - ferric iron transport 1844015..1844974 Streptococcus pneumoniae Hungary19A-6 6029016 YP_001695236.1 CDS SPH_1986 NC_010380.1 1844964 1845920 D identified by match to protein family HMM PF01032; ABC transporter membrane-spanning permease - ferric iron transport 1844964..1845920 Streptococcus pneumoniae Hungary19A-6 6029534 YP_001695237.1 CDS SPH_1987 NC_010380.1 1845917 1846669 D identified by match to protein family HMM PF00005; ferrichrome ABC transporter ATP-binding protein 1845917..1846669 Streptococcus pneumoniae Hungary19A-6 6029795 YP_001695238.1 CDS SPH_1988 NC_010380.1 1846765 1847730 D identified by match to protein family HMM PF01497; iron-compound ABC transporter iron-compound-binding protein 1846765..1847730 Streptococcus pneumoniae Hungary19A-6 6029108 YP_001695239.1 CDS SPH_1989 NC_010380.1 1847955 1848197 R identified by match to protein family HMM PF01809; match to protein family HMM TIGR00278; hypothetical protein complement(1847955..1848197) Streptococcus pneumoniae Hungary19A-6 6029926 YP_001695240.1 CDS rluB NC_010380.1 1848197 1848919 R identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal large subunit pseudouridine synthase B complement(1848197..1848919) Streptococcus pneumoniae Hungary19A-6 6028574 YP_001695241.1 CDS scpB NC_010380.1 1848906 1849475 R functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B complement(1848906..1849475) Streptococcus pneumoniae Hungary19A-6 6027795 YP_001695242.1 CDS scpA NC_010380.1 1849494 1850222 R functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A complement(1849494..1850222) Streptococcus pneumoniae Hungary19A-6 6027710 YP_001695243.1 CDS xerD NC_010380.1 1850222 1850962 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD-like protein complement(1850222..1850962) Streptococcus pneumoniae Hungary19A-6 6029579 YP_001695244.1 CDS SPH_1994 NC_010380.1 1850953 1851414 R identified by match to protein family HMM PF00571; CBS domain-containing protein complement(1850953..1851414) Streptococcus pneumoniae Hungary19A-6 6029043 YP_001695245.1 CDS SPH_1995 NC_010380.1 1851411 1851932 R identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040; phosphodiesterase complement(1851411..1851932) Streptococcus pneumoniae Hungary19A-6 6029535 YP_001695246.1 CDS SPH_1996 NC_010380.1 1851908 1852879 R HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein complement(1851908..1852879) Streptococcus pneumoniae Hungary19A-6 6027783 YP_001695247.1 CDS murI NC_010380.1 1852876 1853670 R converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase complement(1852876..1853670) Streptococcus pneumoniae Hungary19A-6 6029362 YP_001695248.1 CDS SPH_1998 NC_010380.1 1853877 1854125 R identified by match to protein family HMM PF03672; hypothetical protein complement(1853877..1854125) Streptococcus pneumoniae Hungary19A-6 6028841 YP_001695249.1 CDS treC NC_010380.1 1854381 1856006 R identified by match to protein family HMM PF00128; match to protein family HMM TIGR02403; alpha,alpha-phosphotrehalase complement(1854381..1856006) Streptococcus pneumoniae Hungary19A-6 6028913 YP_001695250.1 CDS treP NC_010380.1 1856184 1858151 R identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01992; pts system, trehalose-specific IIBC component complement(1856184..1858151) Streptococcus pneumoniae Hungary19A-6 6029555 YP_001695251.1 CDS treR NC_010380.1 1858336 1859046 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM TIGR02404; trehalose operon repressor 1858336..1859046 Streptococcus pneumoniae Hungary19A-6 6028432 YP_001695252.1 CDS SPH_2005 NC_010380.1 1860602 1861528 R identified by match to protein family HMM PF00005; match to protein family HMM PF08352; oligopeptide transport ATP-binding protein AmiF complement(1860602..1861528) Streptococcus pneumoniae Hungary19A-6 6028151 YP_001695253.1 CDS SPH_2006 NC_010380.1 1861539 1862606 R identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; oligopeptide transport ATP-binding protein OppD complement(1861539..1862606) Streptococcus pneumoniae Hungary19A-6 6028230 YP_001695254.1 CDS SPH_2007 NC_010380.1 1862615 1863541 R identified by match to protein family HMM PF00528; oligopeptide transport system permease AmiD complement(1862615..1863541) Streptococcus pneumoniae Hungary19A-6 6028600 YP_001695255.1 CDS SPH_2008 NC_010380.1 1863541 1865037 R identified by match to protein family HMM PF00528; oligopeptide transport system permease AmiC complement(1863541..1865037) Streptococcus pneumoniae Hungary19A-6 6029519 YP_001695256.1 CDS SPH_2009 NC_010380.1 1865104 1866942 R identified by match to protein family HMM PF00496; AmiA protein complement(1865104..1866942) Streptococcus pneumoniae Hungary19A-6 6027809 YP_001695257.1 CDS SPH_2010 NC_010380.1 1867771 1868964 R identified by match to protein family HMM PF04932; O-antigen polymerase complement(1867771..1868964) Streptococcus pneumoniae Hungary19A-6 6029314 YP_001695258.1 CDS SPH_2011 NC_010380.1 1869102 1870544 R identified by match to protein family HMM PF00128; sucrose phosphorylase (sucrose glucosyltransferase)(glucosyltransferase-A) (GTF-A) complement(1869102..1870544) Streptococcus pneumoniae Hungary19A-6 6028555 YP_001695259.1 CDS SPH_2012 NC_010380.1 1870855 1871688 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1870855..1871688) Streptococcus pneumoniae Hungary19A-6 6028521 YP_001695260.1 CDS SPH_2013 NC_010380.1 1871702 1872568 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1871702..1872568) Streptococcus pneumoniae Hungary19A-6 6028538 YP_001695261.1 CDS SPH_2014 NC_010380.1 1872582 1873841 R identified by match to protein family HMM PF01547; sugar ABC transporter sugar-binding protein complement(1872582..1873841) Streptococcus pneumoniae Hungary19A-6 6029220 YP_001695262.1 CDS SPH_2015 NC_010380.1 1873933 1876095 R identified by match to protein family HMM PF02065; alpha-galactosidase complement(1873933..1876095) Streptococcus pneumoniae Hungary19A-6 6029376 YP_001695263.1 CDS SPH_2016 NC_010380.1 1876203 1877063 D identified by match to protein family HMM PF00165; match to protein family HMM PF02311; msm operon regulatory protein 1876203..1877063 Streptococcus pneumoniae Hungary19A-6 6029041 YP_001695264.1 CDS SPH_2017 NC_010380.1 1877060 1877995 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1877060..1877995 Streptococcus pneumoniae Hungary19A-6 6028856 YP_001695265.1 CDS recX NC_010380.1 1887828 1888604 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1887828..1888604 Streptococcus pneumoniae Hungary19A-6 6029801 YP_001695266.1 CDS SPH_2045 NC_010380.1 1888693 1889226 D identified by match to protein family HMM PF04167; hypothetical protein 1888693..1889226 Streptococcus pneumoniae Hungary19A-6 6027860 YP_001695267.1 CDS SPH_2046 NC_010380.1 1889581 1889787 R hypothetical protein complement(1889581..1889787) Streptococcus pneumoniae Hungary19A-6 6028388 YP_001695268.1 CDS groEL NC_010380.1 1891363 1892985 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL complement(1891363..1892985) Streptococcus pneumoniae Hungary19A-6 6028994 YP_001695269.1 CDS groES NC_010380.1 1893001 1893285 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(1893001..1893285) Streptococcus pneumoniae Hungary19A-6 6029486 YP_001695270.1 CDS SPH_2052 NC_010380.1 1893555 1893950 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1893555..1893950) Streptococcus pneumoniae Hungary19A-6 6029058 YP_001695271.1 CDS SPH_2053 NC_010380.1 1894027 1894788 R identified by match to protein family HMM PF00106; match to protein family HMM PF08659; short chain dehydrogenase/reductase oxidoreductase complement(1894027..1894788) Streptococcus pneumoniae Hungary19A-6 6028664 YP_001695272.1 CDS SPH_2054 NC_010380.1 1894821 1895450 R identified by match to protein family HMM PF01588; hypothetical protein complement(1894821..1895450) Streptococcus pneumoniae Hungary19A-6 6028335 YP_001695273.1 CDS SPH_2055 NC_010380.1 1895466 1895783 R identified by match to protein family HMM PF00085; thioredoxin family protein complement(1895466..1895783) Streptococcus pneumoniae Hungary19A-6 6029815 YP_001695274.1 CDS SPH_2056 NC_010380.1 1895780 1896079 R hypothetical protein complement(1895780..1896079) Streptococcus pneumoniae Hungary19A-6 6029603 YP_001695275.1 CDS SPH_2057 NC_010380.1 1896761 1897435 R hypothetical protein complement(1896761..1897435) Streptococcus pneumoniae Hungary19A-6 6028110 YP_001695276.1 CDS SPH_2058 NC_010380.1 1897441 1897887 R identified by match to protein family HMM PF04397; response regulator complement(1897441..1897887) Streptococcus pneumoniae Hungary19A-6 6027886 YP_001695277.1 CDS SPH_2059 NC_010380.1 1898001 1898504 R identified by match to protein family HMM PF01569; PAP2 family protein complement(1898001..1898504) Streptococcus pneumoniae Hungary19A-6 6028895 YP_001695278.1 CDS SPH_2060 NC_010380.1 1898501 1898863 R hypothetical protein complement(1898501..1898863) Streptococcus pneumoniae Hungary19A-6 6029456 YP_001695279.1 CDS SPH_2063 NC_010380.1 1900805 1901275 R identified by match to protein family HMM PF01047; MarR family transcriptional regulator complement(1900805..1901275) Streptococcus pneumoniae Hungary19A-6 6027700 YP_001695280.1 CDS SPH_2064 NC_010380.1 1901399 1902115 R identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein complement(1901399..1902115) Streptococcus pneumoniae Hungary19A-6 6028191 YP_001695281.1 CDS SPH_2065 NC_010380.1 1902996 1904411 R identified by match to protein family HMM PF01289; pneumolysin (Thiol-activated cytolysin) complement(1902996..1904411) Streptococcus pneumoniae Hungary19A-6 6027944 YP_001695282.1 CDS SPH_2066 NC_010380.1 1904422 1904754 R hypothetical protein complement(1904422..1904754) Streptococcus pneumoniae Hungary19A-6 6029793 YP_001695283.1 CDS SPH_2067 NC_010380.1 1904825 1905433 R hypothetical protein complement(1904825..1905433) Streptococcus pneumoniae Hungary19A-6 6028916 YP_001695284.1 CDS SPH_2069 NC_010380.1 1906029 1906160 D mobile genetic element 1906029..1906160 Streptococcus pneumoniae Hungary19A-6 6029303 YP_001695285.1 CDS SPH_2070 NC_010380.1 1906165 1906428 D mobile genetic element 1906165..1906428 Streptococcus pneumoniae Hungary19A-6 6029196 YP_001695286.1 CDS SPH_2071 NC_010380.1 1906905 1907738 D identified by glimmer; hypothetical protein 1906905..1907738 Streptococcus pneumoniae Hungary19A-6 6029624 YP_001695287.1 CDS SPH_2072 NC_010380.1 1907765 1908826 D ABC transporter substrate-binding protein 1907765..1908826 Streptococcus pneumoniae Hungary19A-6 6028460 YP_001695288.1 CDS SPH_2073 NC_010380.1 1908843 1909847 D identified by match to protein family HMM PF00005; spermidine/putrescine ABC transporter ATP-binding subunit 1908843..1909847 Streptococcus pneumoniae Hungary19A-6 6028165 YP_001695289.1 CDS SPH_2074 NC_010380.1 1909859 1911553 D identified by match to protein family HMM PF00528; binding-protein-dependent transport systems inner membrane component 1909859..1911553 Streptococcus pneumoniae Hungary19A-6 6029796 YP_001695290.1 CDS SPH_2075 NC_010380.1 1911555 1912256 D identified by match to protein family HMM PF02308; MgtC/SapB transporter 1911555..1912256 Streptococcus pneumoniae Hungary19A-6 6028078 YP_001695291.1 CDS SPH_2076 NC_010380.1 1912303 1912902 D identified by match to protein family HMM PF00702; match to protein family HMM TIGR01509; hydrolase 1912303..1912902 Streptococcus pneumoniae Hungary19A-6 6027717 YP_001695292.1 CDS SPH_2077 NC_010380.1 1912912 1914939 D identified by match to protein family HMM PF00356; transcriptional regulator, LacI family protein 1912912..1914939 Streptococcus pneumoniae Hungary19A-6 6029537 YP_001695293.1 CDS SPH_2079 NC_010380.1 1915513 1915902 D identified by match to protein family HMM PF01609; IS4 family transposase 1915513..1915902 Streptococcus pneumoniae Hungary19A-6 6030010 YP_001695294.1 CDS SPH_2080 NC_010380.1 1916640 1916900 R hypothetical protein complement(1916640..1916900) Streptococcus pneumoniae Hungary19A-6 6029845 YP_001695295.1 CDS SPH_2081 NC_010380.1 1916959 1917510 R hypothetical protein complement(1916959..1917510) Streptococcus pneumoniae Hungary19A-6 6028014 YP_001695296.1 CDS SPH_2082 NC_010380.1 1917500 1918495 R hypothetical protein complement(1917500..1918495) Streptococcus pneumoniae Hungary19A-6 6028175 YP_001695297.1 CDS SPH_2083 NC_010380.1 1918903 1919328 R hypothetical protein complement(1918903..1919328) Streptococcus pneumoniae Hungary19A-6 6028360 YP_001695298.1 CDS SPH_2084 NC_010380.1 1919457 1919816 R hypothetical protein complement(1919457..1919816) Streptococcus pneumoniae Hungary19A-6 6028215 YP_001695299.1 CDS SPH_2086 NC_010380.1 1920055 1920216 R type II restriction-modification system regulatory protein complement(1920055..1920216) Streptococcus pneumoniae Hungary19A-6 6029402 YP_001695300.1 CDS SPH_2087 NC_010380.1 1920562 1921335 R N-acetylmuramoyl-L-alanine amidase; Mureinhydrolase; Mucopeptide aminohydrolase; Cell wall hydrolase; identified by match to protein family HMM PF01473; autolysin complement(1920562..1921335) Streptococcus pneumoniae Hungary19A-6 6029158 YP_001695301.1 CDS SPH_2088 NC_010380.1 1921894 1923264 R identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; DNA-damage-inducible protein complement(1921894..1923264) Streptococcus pneumoniae Hungary19A-6 6029394 YP_001695302.1 CDS recA NC_010380.1 1923571 1924737 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(1923571..1924737) Streptococcus pneumoniae Hungary19A-6 6028051 YP_001695303.1 CDS SPH_2090 NC_010380.1 1924792 1926048 R identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; competence damage-inducible protein A complement(1924792..1926048) Streptococcus pneumoniae Hungary19A-6 6029463 YP_001695304.1 CDS SPH_2091 NC_010380.1 1926133 1927149 R identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; regulator of lytrabc operon complement(1926133..1927149) Streptococcus pneumoniae Hungary19A-6 6029977 YP_001695305.1 CDS SPH_2092 NC_010380.1 1927157 1927675 R identified by match to protein family HMM PF00583; acetyltransferase complement(1927157..1927675) Streptococcus pneumoniae Hungary19A-6 6029915 YP_001695306.1 CDS SPH_2093 NC_010380.1 1927665 1928108 R identified by match to protein family HMM PF02367; match to protein family HMM TIGR00150; hypothetical protein complement(1927665..1928108) Streptococcus pneumoniae Hungary19A-6 6029291 YP_001695307.1 CDS SPH_2094 NC_010380.1 1928194 1928814 R lipoprotein complement(1928194..1928814) Streptococcus pneumoniae Hungary19A-6 6027758 YP_001695308.1 CDS SPH_2095 NC_010380.1 1929197 1930060 R identified by match to protein family HMM PF01381; transcriptional activator complement(1929197..1930060) Streptococcus pneumoniae Hungary19A-6 6028481 YP_001695309.1 CDS SPH_2096 NC_010380.1 1930732 1931028 D hypothetical protein 1930732..1931028 Streptococcus pneumoniae Hungary19A-6 6029805 YP_001695310.1 CDS SPH_2097 NC_010380.1 1931131 1933146 D identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; bacteriocin-associated integral membrane protein 1931131..1933146 Streptococcus pneumoniae Hungary19A-6 6029547 YP_001695311.1 CDS SPH_2098 NC_010380.1 1933148 1933780 D identified by match to protein family HMM PF00005; peptide ABC transporter ATPase 1933148..1933780 Streptococcus pneumoniae Hungary19A-6 6027887 YP_001695312.1 CDS SPH_2099 NC_010380.1 1933921 1934082 D hypothetical protein 1933921..1934082 Streptococcus pneumoniae Hungary19A-6 6028621 YP_001695313.1 CDS ndk NC_010380.1 1934708 1935121 R NDK; NDP kinase; Abnormal wing disks protein; Killer of prune protein; catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(1934708..1935121) Streptococcus pneumoniae Hungary19A-6 6028634 YP_001695314.1 CDS rpoC NC_010380.1 1935232 1938909 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(1935232..1938909) Streptococcus pneumoniae Hungary19A-6 6029666 YP_001695315.1 CDS rpoB NC_010380.1 1938942 1942553 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(1938942..1942553) Streptococcus pneumoniae Hungary19A-6 6028835 YP_001695316.1 CDS SPH_2104 NC_010380.1 1943056 1943175 R identified by glimmer; hypothetical protein complement(1943056..1943175) Streptococcus pneumoniae Hungary19A-6 6028549 YP_001695317.1 CDS SPH_2105 NC_010380.1 1943237 1944568 R identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471; CBS domain-containing protein complement(1943237..1944568) Streptococcus pneumoniae Hungary19A-6 6028842 YP_001695318.1 CDS SPH_2106 NC_010380.1 1944859 1945683 R identified by match to protein family HMM PF01223; DNA-entry nuclease (competence-specific nuclease) complement(1944859..1945683) Streptococcus pneumoniae Hungary19A-6 6030063 YP_001695319.1 CDS SPH_2107 NC_010380.1 1945722 1945910 R hypothetical protein complement(1945722..1945910) Streptococcus pneumoniae Hungary19A-6 6028062 YP_001695320.1 CDS murA2 NC_010380.1 1945903 1947186 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(1945903..1947186) Streptococcus pneumoniae Hungary19A-6 6028088 YP_001695321.1 CDS SPH_2109 NC_010380.1 1947210 1947407 R identified by match to protein family HMM TIGR02327; hypothetical protein complement(1947210..1947407) Streptococcus pneumoniae Hungary19A-6 6029451 YP_001695322.1 CDS SPH_2110 NC_010380.1 1947498 1948535 R ATP-dependent protease La complement(1947498..1948535) Streptococcus pneumoniae Hungary19A-6 6028085 YP_001695323.1 CDS coaD NC_010380.1 1948519 1949007 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(1948519..1949007) Streptococcus pneumoniae Hungary19A-6 6027786 YP_001695324.1 CDS SPH_2112 NC_010380.1 1948997 1949536 R identified by match to protein family HMM PF03602; match to protein family HMM TIGR00095; N-6 adenine-specific DNA methylase complement(1948997..1949536) Streptococcus pneumoniae Hungary19A-6 6027833 YP_001695325.1 CDS asnA NC_010380.1 1949601 1950593 R catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA complement(1949601..1950593) Streptococcus pneumoniae Hungary19A-6 6029644 YP_001695326.1 CDS SPH_2114 NC_010380.1 1950706 1951389 R identified by match to protein family HMM PF01027; membrane protein complement(1950706..1951389) Streptococcus pneumoniae Hungary19A-6 6029424 YP_001695327.1 CDS SPH_2115 NC_010380.1 1951445 1952185 R identified by match to protein family HMM PF00588; match to protein family HMM PF08032; rRNA/tRNA methylase complement(1951445..1952185) Streptococcus pneumoniae Hungary19A-6 6030082 YP_001695328.1 CDS SPH_2116 NC_010380.1 1952219 1952497 D catalyzes the hydrolysis of acylphosphate; acylphosphatase 1952219..1952497 Streptococcus pneumoniae Hungary19A-6 6029331 YP_001695329.1 CDS SPH_2117 NC_010380.1 1952575 1953501 D involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor 1952575..1953501 Streptococcus pneumoniae Hungary19A-6 6029015 YP_001695330.1 CDS pflA NC_010380.1 1953576 1954370 R identified by match to protein family HMM PF04055; match to protein family HMM TIGR02493; pyruvate formate-lyase 1-activating enzyme complement(1953576..1954370) Streptococcus pneumoniae Hungary19A-6 6028725 YP_001695331.1 CDS SPH_2119 NC_010380.1 1954496 1955746 R identified by match to protein family HMM PF00278; match to protein family HMM PF02784; diaminopimelate decarboxylase complement(1954496..1955746) Streptococcus pneumoniae Hungary19A-6 6028408 YP_001695332.1 CDS purR NC_010380.1 1955813 1956640 R identified by match to protein family HMM PF00156; match to protein family HMM PF09182; match to protein family HMM TIGR01743; pur operon repressor complement(1955813..1956640) Streptococcus pneumoniae Hungary19A-6 6028919 YP_001695333.1 CDS SPH_2121 NC_010380.1 1956907 1957848 R identified by match to protein family HMM PF01336; match to protein family HMM PF01966; 3'-5' exoribonuclease complement(1956907..1957848) Streptococcus pneumoniae Hungary19A-6 6027949 YP_001695334.1 CDS SPH_2122 NC_010380.1 1957838 1959094 R identified by match to protein family HMM PF02646; competence-induced protein Ccs50 complement(1957838..1959094) Streptococcus pneumoniae Hungary19A-6 6028430 YP_001695335.1 CDS SPH_2123 NC_010380.1 1959096 1959758 R identified by match to protein family HMM PF04263; match to protein family HMM PF04265; match to protein family HMM TIGR01378; thiamine pyrophosphokinase complement(1959096..1959758) Streptococcus pneumoniae Hungary19A-6 6029307 YP_001695336.1 CDS rpe NC_010380.1 1959721 1960377 R identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163; ribulose-phosphate 3-epimerase complement(1959721..1960377) Streptococcus pneumoniae Hungary19A-6 6027749 YP_001695337.1 CDS rsgA NC_010380.1 1960388 1961266 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(1960388..1961266) Streptococcus pneumoniae Hungary19A-6 6029268 YP_001695338.1 CDS ksgA NC_010380.1 1961268 1962140 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(1961268..1962140) Streptococcus pneumoniae Hungary19A-6 6028069 YP_001695339.1 CDS SPH_2127 NC_010380.1 1962271 1962579 R hypothetical protein complement(1962271..1962579) Streptococcus pneumoniae Hungary19A-6 6029802 YP_001695340.1 CDS SPH_2128 NC_010380.1 1962572 1963213 R identified by match to protein family HMM PF00005; peptide ABC transporter ATPase complement(1962572..1963213) Streptococcus pneumoniae Hungary19A-6 6027929 YP_001695341.1 CDS SPH_2129 NC_010380.1 1963215 1965245 R identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; immunity protein complement(1963215..1965245) Streptococcus pneumoniae Hungary19A-6 6029239 YP_001695342.1 CDS SPH_2130 NC_010380.1 1965322 1965618 R identified by match to protein family HMM TIGR01653; lactococcin 972 complement(1965322..1965618) Streptococcus pneumoniae Hungary19A-6 6028299 YP_001695343.1 CDS SPH_2131 NC_010380.1 1965932 1966831 R identified by match to protein family HMM PF01381; transcriptional activator complement(1965932..1966831) Streptococcus pneumoniae Hungary19A-6 6028817 YP_001695344.1 CDS SPH_2132 NC_010380.1 1966903 1967463 R identified by match to protein family HMM PF01751; match to protein family HMM TIGR00334; primase-like protein complement(1966903..1967463) Streptococcus pneumoniae Hungary19A-6 6029990 YP_001695345.1 CDS SPH_2133 NC_010380.1 1967463 1968236 R identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010; TatD family deoxyribonuclease complement(1967463..1968236) Streptococcus pneumoniae Hungary19A-6 6029028 YP_001695346.1 CDS SPH_2134 NC_010380.1 1968541 1969440 R identified by match to protein family HMM PF00746; match to protein family HMM PF07564; match to protein family HMM TIGR01167; cell wall surface anchor family protein complement(1968541..1969440) Streptococcus pneumoniae Hungary19A-6 6028854 YP_001695347.1 CDS rpmH NC_010380.1 1969724 1969858 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(1969724..1969858) Streptococcus pneumoniae Hungary19A-6 6027915 YP_001695348.1 CDS SPH_2136 NC_010380.1 1970003 1971217 R broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase complement(1970003..1971217) Streptococcus pneumoniae Hungary19A-6 6028775 YP_001695349.1 CDS SPH_2137 NC_010380.1 1971373 1971666 R hypothetical protein complement(1971373..1971666) Streptococcus pneumoniae Hungary19A-6 6028925 YP_001695350.1 CDS SPH_2138 NC_010380.1 1971828 1972280 D identified by match to protein family HMM PF00582; universal stress protein 1971828..1972280 Streptococcus pneumoniae Hungary19A-6 6028975 YP_001695351.1 CDS SPH_2139 NC_010380.1 1972315 1973664 R identified by match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; Cof family protein complement(1972315..1973664) Streptococcus pneumoniae Hungary19A-6 6029070 YP_001695352.1 CDS SPH_2141 NC_010380.1 1973768 1974730 D identified by match to protein family HMM PF00710; L-asparaginase 1973768..1974730 Streptococcus pneumoniae Hungary19A-6 6029882 YP_001695353.1 CDS SPH_2140 NC_010380.1 1974727 1975008 R chlorohydrolase complement(1974727..1975008) Streptococcus pneumoniae Hungary19A-6 6028437 YP_001695354.1 CDS ccpA NC_010380.1 1975072 1976082 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; match to protein family HMM TIGR01481; catabolite control protein A complement(1975072..1976082) Streptococcus pneumoniae Hungary19A-6 6029776 YP_001695355.1 CDS SPH_2143 NC_010380.1 1976507 1977106 R identified by match to protein family HMM PF00072; match to protein family HMM PF00196; response regulator complement(1976507..1977106) Streptococcus pneumoniae Hungary19A-6 6029610 YP_001695356.1 CDS SPH_2144 NC_010380.1 1977108 1978205 R identified by match to protein family HMM PF02518; match to protein family HMM PF07730; histidine kinase complement(1977108..1978205) Streptococcus pneumoniae Hungary19A-6 6027993 YP_001695357.1 CDS SPH_2145 NC_010380.1 1978205 1978942 R identified by match to protein family HMM PF01061; ABC-type multidrug transport system, permease component complement(1978205..1978942) Streptococcus pneumoniae Hungary19A-6 6028254 YP_001695358.1 CDS SPH_2146 NC_010380.1 1978944 1979828 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1978944..1979828) Streptococcus pneumoniae Hungary19A-6 6029800 YP_001695359.1 CDS SPH_2147 NC_010380.1 1979815 1980009 R hypothetical protein complement(1979815..1980009) Streptococcus pneumoniae Hungary19A-6 6028904 YP_001695360.1 CDS SPH_2148 NC_010380.1 1980006 1980212 R hypothetical protein complement(1980006..1980212) Streptococcus pneumoniae Hungary19A-6 6029128 YP_001695361.1 CDS SPH_2163 NC_010380.1 1986892 1987371 R competence-specific global transcription modulator complement(1986892..1987371) Streptococcus pneumoniae Hungary19A-6 6028060 YP_001695362.1 CDS nusG NC_010380.1 1987493 1988029 R Modulates Rho-dependent transcription termination; transcription antitermination protein NusG complement(1987493..1988029) Streptococcus pneumoniae Hungary19A-6 6027927 YP_001695363.1 CDS secE NC_010380.1 1988084 1988260 R forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(1988084..1988260) Streptococcus pneumoniae Hungary19A-6 6028317 YP_001695364.1 CDS SPH_2166 NC_010380.1 1988475 1990670 R identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 2A complement(1988475..1990670) Streptococcus pneumoniae Hungary19A-6 6028807 YP_001695365.1 CDS SPH_2167 NC_010380.1 1990796 1991632 D identified by match to protein family HMM PF00849; ribosomal large subunit pseudouridine synthase D 1990796..1991632 Streptococcus pneumoniae Hungary19A-6 6027828 YP_001695366.1 CDS gap NC_010380.1 1991699 1992706 R identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; glyceraldehyde-3-phosphate dehydrogenase, type I complement(1991699..1992706) Streptococcus pneumoniae Hungary19A-6 6028863 YP_001695367.1 CDS SPH_2169 NC_010380.1 1992883 1993716 R identified by match to protein family HMM PF02687; ABC transporter permease complement(1992883..1993716) Streptococcus pneumoniae Hungary19A-6 6029790 YP_001695368.1 CDS SPH_2170 NC_010380.1 1994436 1994765 R identified by match to protein family HMM PF01710; transposase complement(1994436..1994765) Streptococcus pneumoniae Hungary19A-6 6027961 YP_001695369.1 CDS nadC NC_010380.1 1994896 1995768 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase complement(1994896..1995768) Streptococcus pneumoniae Hungary19A-6 6028185 YP_001695370.1 CDS SPH_2172 NC_010380.1 1996005 1997315 D identified by match to protein family HMM PF03600; match to protein family HMM PF07158; membrane protein 1996005..1997315 Streptococcus pneumoniae Hungary19A-6 6030014 YP_001695371.1 CDS SPH_2173 NC_010380.1 1997681 1997812 R hypothetical protein complement(1997681..1997812) Streptococcus pneumoniae Hungary19A-6 6029690 YP_001695372.1 CDS SPH_2174 NC_010380.1 1998334 1999062 R identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator complement(1998334..1999062) Streptococcus pneumoniae Hungary19A-6 6027990 YP_001695373.1 CDS SPH_2175 NC_010380.1 1999220 2000629 D identified by match to protein family HMM PF00232; beta-glucosidase 1999220..2000629 Streptococcus pneumoniae Hungary19A-6 6028245 YP_001695374.1 CDS SPH_2176 NC_010380.1 2000647 2001942 D identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; phosphotransferase system system, cellobiose-specific IIC component 2000647..2001942 Streptococcus pneumoniae Hungary19A-6 6028940 YP_001695375.1 CDS SPH_2177 NC_010380.1 2001947 2002255 D pts system lichenan-specific eiib component; eiib-lic; identified by match to protein family HMM PF02302; lichenan-specific phosphotransferase enzyme IIB component 2001947..2002255 Streptococcus pneumoniae Hungary19A-6 6029083 YP_001695376.1 CDS SPH_2178 NC_010380.1 2002252 2002560 D pts system lichenan-specific eiia component; eiia-lic; eiii-lic; identified by match to protein family HMM PF02255; lichenan-specific phosphotransferase enzyme IIA component 2002252..2002560 Streptococcus pneumoniae Hungary19A-6 6029142 YP_001695377.1 CDS SPH_2179 NC_010380.1 2003546 2006197 R identified by match to protein family HMM PF00465; bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(2003546..2006197) Streptococcus pneumoniae Hungary19A-6 6029446 YP_001695378.1 CDS SPH_2180 NC_010380.1 2006498 2006908 R identified by match to protein family HMM PF02493; MORN motif-containing protein complement(2006498..2006908) Streptococcus pneumoniae Hungary19A-6 6028334 YP_001695379.1 CDS SPH_2181 NC_010380.1 2006910 2007338 R identified by match to protein family HMM PF01451; phosphotyrosine protein phosphatase complement(2006910..2007338) Streptococcus pneumoniae Hungary19A-6 6029607 YP_001695380.1 CDS yajC NC_010380.1 2007385 2007684 R member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC complement(2007385..2007684) Streptococcus pneumoniae Hungary19A-6 6028740 YP_001695381.1 CDS tkt2 NC_010380.1 2007801 2009777 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(2007801..2009777) Streptococcus pneumoniae Hungary19A-6 6029581 YP_001695382.1 CDS SPH_2184 NC_010380.1 2009891 2010982 R L-ascorbate 6-phosphate lactonase complement(2009891..2010982) Streptococcus pneumoniae Hungary19A-6 6028882 YP_001695383.1 CDS SPH_2185 NC_010380.1 2011094 2012767 R identified by match to protein family HMM PF00874; match to protein family HMM PF08279; BglG family transcriptional regulator complement(2011094..2012767) Streptococcus pneumoniae Hungary19A-6 6029735 YP_001695384.1 CDS araD NC_010380.1 2012944 2013648 R catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase complement(2012944..2013648) Streptococcus pneumoniae Hungary19A-6 6029495 YP_001695385.1 CDS SPH_2187 NC_010380.1 2013650 2014513 R L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase complement(2013650..2014513) Streptococcus pneumoniae Hungary19A-6 6029817 YP_001695386.1 CDS ulaD NC_010380.1 2014517 2015182 R catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase complement(2014517..2015182) Streptococcus pneumoniae Hungary19A-6 6029150 YP_001695387.1 CDS SPH_2189 NC_010380.1 2015199 2015684 R identified by match to protein family HMM PF00359; ascorbate-specific phosphotransferase IIA component complement(2015199..2015684) Streptococcus pneumoniae Hungary19A-6 6028141 YP_001695388.1 CDS SPH_2190 NC_010380.1 2015761 2016042 R identified by match to protein family HMM PF02302; ascorbate-specific phosphotransferase IIB component complement(2015761..2016042) Streptococcus pneumoniae Hungary19A-6 6030081 YP_001695389.1 CDS SPH_2191 NC_010380.1 2016065 2017522 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(2016065..2017522) Streptococcus pneumoniae Hungary19A-6 6028516 YP_001695390.1 CDS SPH_2192 NC_010380.1 2017653 2018276 R hypothetical protein complement(2017653..2018276) Streptococcus pneumoniae Hungary19A-6 6029066 YP_001695391.1 CDS SPH_2193 NC_010380.1 2018327 2019313 R identified by match to protein family HMM PF01424; jag protein complement(2018327..2019313) Streptococcus pneumoniae Hungary19A-6 6028457 YP_001695392.1 CDS SPH_2194 NC_010380.1 2019332 2020162 R identified by match to protein family HMM PF02096; membrane protein OxaA 1 complement(2019332..2020162) Streptococcus pneumoniae Hungary19A-6 6029255 YP_001695393.1 CDS rnpA NC_010380.1 2020131 2020502 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(2020131..2020502) Streptococcus pneumoniae Hungary19A-6 6029224 YP_001695394.1 CDS SPH_2196 NC_010380.1 2020519 2020650 R hypothetical protein complement(2020519..2020650) Streptococcus pneumoniae Hungary19A-6 6028838 YP_001695395.1 CDS ackA NC_010380.1 2020651 2021841 R AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase complement(2020651..2021841) Streptococcus pneumoniae Hungary19A-6 6028565 YP_001695396.1 CDS SPH_2198 NC_010380.1 2021892 2022845 R adenine-specific DNA methylase complement(2021892..2022845) Streptococcus pneumoniae Hungary19A-6 6029227 YP_001695397.1 CDS SPH_2200 NC_010380.1 2023318 2023500 R hypothetical protein complement(2023318..2023500) Streptococcus pneumoniae Hungary19A-6 6028558 YP_001695398.1 CDS SPH_2201 NC_010380.1 2023637 2024050 R hypothetical protein complement(2023637..2024050) Streptococcus pneumoniae Hungary19A-6 6029850 YP_001695399.1 CDS SPH_2202 NC_010380.1 2024028 2024489 R competence protein ComGF complement(2024028..2024489) Streptococcus pneumoniae Hungary19A-6 6029754 YP_001695400.1 CDS SPH_2203 NC_010380.1 2024452 2024712 R hypothetical protein complement(2024452..2024712) Streptococcus pneumoniae Hungary19A-6 6027980 YP_001695401.1 CDS SPH_2204 NC_010380.1 2024717 2025103 R competence protein CglD complement(2024717..2025103) Streptococcus pneumoniae Hungary19A-6 6029012 YP_001695402.1 CDS SPH_2205 NC_010380.1 2025114 2025437 R identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532; competence protein complement(2025114..2025437) Streptococcus pneumoniae Hungary19A-6 6029787 YP_001695403.1 CDS SPH_2206 NC_010380.1 2025439 2026287 R identified by match to protein family HMM PF00482; competence protein CglB complement(2025439..2026287) Streptococcus pneumoniae Hungary19A-6 6029650 YP_001695404.1 CDS SPH_2207 NC_010380.1 2026403 2027344 R identified by match to protein family HMM PF00437; ABC transporter subunit ComYA complement(2026403..2027344) Streptococcus pneumoniae Hungary19A-6 6029889 YP_001695405.1 CDS SPH_2208 NC_010380.1 2027420 2027785 R identified by match to protein family HMM PF06279; hypothetical protein complement(2027420..2027785) Streptococcus pneumoniae Hungary19A-6 6028629 YP_001695406.1 CDS SPH_2210 NC_010380.1 2029356 2030414 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; alcohol dehydrogenase complement(2029356..2030414) Streptococcus pneumoniae Hungary19A-6 6028738 YP_001695407.1 CDS nagA NC_010380.1 2030577 2031728 R identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221; N-acetylglucosamine-6-phosphate deacetylase complement(2030577..2031728) Streptococcus pneumoniae Hungary19A-6 6029467 YP_001695408.1 CDS SPH_2212 NC_010380.1 2031880 2033697 R identified by match to protein family HMM PF01757; acyltransferase complement(2031880..2033697) Streptococcus pneumoniae Hungary19A-6 6028733 YP_001695409.1 CDS tgt NC_010380.1 2033798 2034940 R Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase complement(2033798..2034940) Streptococcus pneumoniae Hungary19A-6 6028523 YP_001695410.1 CDS SPH_2218 NC_010380.1 2037564 2037677 R hypothetical protein complement(2037564..2037677) Streptococcus pneumoniae Hungary19A-6 6028506 YP_001695411.1 CDS SPH_2219 NC_010380.1 2037887 2039029 R identified by match to protein family HMM PF01476; LysM domain-containing protein complement(2037887..2039029) Streptococcus pneumoniae Hungary19A-6 6029560 YP_001695412.1 CDS SPH_2220 NC_010380.1 2039195 2039815 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; phosphoglycolate phosphatase complement(2039195..2039815) Streptococcus pneumoniae Hungary19A-6 6028834 YP_001695413.1 CDS SPH_2221 NC_010380.1 2039819 2041099 R identified by match to protein family HMM PF01554; match to protein family HMM PF03023; match to protein family HMM TIGR00797; multi anti extrusion complement(2039819..2041099) Streptococcus pneumoniae Hungary19A-6 6028455 YP_001695414.1 CDS thrC NC_010380.1 2041160 2042644 R catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase complement(2041160..2042644) Streptococcus pneumoniae Hungary19A-6 6028797 YP_001695415.1 CDS SPH_2223 NC_010380.1 2042720 2043997 R hypothetical protein complement(2042720..2043997) Streptococcus pneumoniae Hungary19A-6 6028402 YP_001695416.1 CDS SPH_2224 NC_010380.1 2044289 2044468 R identified by glimmer; hypothetical protein complement(2044289..2044468) Streptococcus pneumoniae Hungary19A-6 6030078 YP_001695417.1 CDS SPH_2225 NC_010380.1 2044718 2044831 D identified by glimmer; hypothetical protein 2044718..2044831 Streptococcus pneumoniae Hungary19A-6 6029032 YP_001695418.1 CDS SPH_2226 NC_010380.1 2044812 2045267 D identified by glimmer; hypothetical protein 2044812..2045267 Streptococcus pneumoniae Hungary19A-6 6028400 YP_001695419.1 CDS SPH_2227 NC_010380.1 2045325 2046179 D identified by match to protein family HMM PF03372; hypothetical protein 2045325..2046179 Streptococcus pneumoniae Hungary19A-6 6030008 YP_001695420.1 CDS SPH_2228 NC_010380.1 2046445 2047764 D identified by match to protein family HMM PF01580; hypothetical protein 2046445..2047764 Streptococcus pneumoniae Hungary19A-6 6028343 YP_001695421.1 CDS SPH_2229 NC_010380.1 2047854 2048168 D hypothetical protein 2047854..2048168 Streptococcus pneumoniae Hungary19A-6 6029808 YP_001695422.1 CDS SPH_2230 NC_010380.1 2048202 2048591 D hypothetical protein 2048202..2048591 Streptococcus pneumoniae Hungary19A-6 6028011 YP_001695423.1 CDS SPH_2231 NC_010380.1 2048758 2049504 D identified by match to protein family HMM PF00149; Ser/Thr protein phosphatase 2048758..2049504 Streptococcus pneumoniae Hungary19A-6 6028641 YP_001695424.1 CDS SPH_2232 NC_010380.1 2049714 2050493 D Rep protein 2049714..2050493 Streptococcus pneumoniae Hungary19A-6 6028522 YP_001695425.1 CDS SPH_2233 NC_010380.1 2050510 2050713 D hypothetical protein 2050510..2050713 Streptococcus pneumoniae Hungary19A-6 6028231 YP_001695426.1 CDS SPH_2234 NC_010380.1 2050717 2051850 D identified by match to protein family HMM PF00589; phage integrase site specific recombinase 2050717..2051850 Streptococcus pneumoniae Hungary19A-6 6029740 YP_001695427.1 CDS SPH_2235 NC_010380.1 2051891 2052328 D metal dependent phosphohydrolase, HD region 2051891..2052328 Streptococcus pneumoniae Hungary19A-6 6029236 YP_001695428.1 CDS SPH_2236 NC_010380.1 2052543 2052779 D identified by match to protein family HMM PF01402; CopG family protein 2052543..2052779 Streptococcus pneumoniae Hungary19A-6 6029840 YP_001695429.1 CDS SPH_2237 NC_010380.1 2052772 2053503 D identified by match to protein family HMM PF00149; serine/threonine protein phosphatase 2052772..2053503 Streptococcus pneumoniae Hungary19A-6 6029694 YP_001695430.1 CDS SPH_2238 NC_010380.1 2053542 2054798 R identified by match to protein family HMM PF01610; transposase complement(2053542..2054798) Streptococcus pneumoniae Hungary19A-6 6029355 YP_001695431.1 CDS SPH_2255 NC_010380.1 2061397 2061831 R cytidine/deoxycytidylate deaminase complement(2061397..2061831) Streptococcus pneumoniae Hungary19A-6 6028719 YP_001695432.1 CDS gltX NC_010380.1 2061845 2063305 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(2061845..2063305) Streptococcus pneumoniae Hungary19A-6 6029011 YP_001695433.1 CDS pgi NC_010380.1 2063429 2064778 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(2063429..2064778) Streptococcus pneumoniae Hungary19A-6 6028279 YP_001695434.1 CDS SPH_2258 NC_010380.1 2064765 2064944 R hypothetical protein complement(2064765..2064944) Streptococcus pneumoniae Hungary19A-6 6029318 YP_001695435.1 CDS SPH_2259 NC_010380.1 2064948 2065637 R identified by match to protein family HMM PF00117; match to protein family HMM PF07722; glutamine amidotransferase complement(2064948..2065637) Streptococcus pneumoniae Hungary19A-6 6028349 YP_001695436.1 CDS SPH_2260 NC_010380.1 2065776 2067542 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding/permease complement(2065776..2067542) Streptococcus pneumoniae Hungary19A-6 6029365 YP_001695437.1 CDS SPH_2261 NC_010380.1 2067629 2067748 R identified by glimmer; hypothetical protein complement(2067629..2067748) Streptococcus pneumoniae Hungary19A-6 6030000 YP_001695438.1 CDS SPH_2262 NC_010380.1 2067794 2068003 D transposase 2067794..2068003 Streptococcus pneumoniae Hungary19A-6 6027880 YP_001695439.1 CDS SPH_2263 NC_010380.1 2068332 2070026 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding/permease complement(2068332..2070026) Streptococcus pneumoniae Hungary19A-6 6027790 YP_001695440.1 CDS mutS NC_010380.1 2070173 2072707 R This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS complement(2070173..2072707) Streptococcus pneumoniae Hungary19A-6 6029693 YP_001695441.1 CDS argR NC_010380.1 2072758 2073204 R identified by match to protein family HMM PF01316; match to protein family HMM PF02863; match to protein family HMM TIGR01529; arginine repressor ArgR complement(2072758..2073204) Streptococcus pneumoniae Hungary19A-6 6028435 YP_001695442.1 CDS argS NC_010380.1 2073340 2075031 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 2073340..2075031 Streptococcus pneumoniae Hungary19A-6 6029574 YP_001695443.1 CDS SPH_2267 NC_010380.1 2075222 2075611 R identified by match to protein family HMM PF01609; mobile genetic element complement(2075222..2075611) Streptococcus pneumoniae Hungary19A-6 6027891 YP_001695444.1 CDS SPH_2268 NC_010380.1 2075765 2076250 D identified by match to protein family HMM PF06172; hypothetical protein 2075765..2076250 Streptococcus pneumoniae Hungary19A-6 6029997 YP_001695445.1 CDS SPH_2269 NC_010380.1 2076334 2077041 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; alkaline phosphatase synthesis transcriptional regulatory protein PhoP 2076334..2077041 Streptococcus pneumoniae Hungary19A-6 6030079 YP_001695446.1 CDS SPH_2270 NC_010380.1 2077042 2078373 D identified by match to protein family HMM PF00512; match to protein family HMM PF02518; histidine kinase PnpS 2077042..2078373 Streptococcus pneumoniae Hungary19A-6 6029103 YP_001695447.1 CDS SPH_2271 NC_010380.1 2078540 2079415 D ABC transporter substrate-binding protein - phosphate transport 2078540..2079415 Streptococcus pneumoniae Hungary19A-6 6027960 YP_001695448.1 CDS pstC2 NC_010380.1 2079533 2080396 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease PstC 2079533..2080396 Streptococcus pneumoniae Hungary19A-6 6027738 YP_001695449.1 CDS pstA2 NC_010380.1 2080389 2081204 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease PstA 2080389..2081204 Streptococcus pneumoniae Hungary19A-6 6028067 YP_001695450.1 CDS pstB3 NC_010380.1 2081206 2081958 D ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 2081206..2081958 Streptococcus pneumoniae Hungary19A-6 6028648 YP_001695451.1 CDS phoU2 NC_010380.1 2081973 2082623 D identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU 2081973..2082623 Streptococcus pneumoniae Hungary19A-6 6028849 YP_001695452.1 CDS SPH_2276 NC_010380.1 2082699 2083124 D transposase, IS1380-Spn1 related, truncation 2082699..2083124 Streptococcus pneumoniae Hungary19A-6 6029049 YP_001695453.1 CDS gpsA NC_010380.1 2083890 2084906 D NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; NAD(P)H-dependentdihydroxyacetone-phosphate reductase; catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 2083890..2084906 Streptococcus pneumoniae Hungary19A-6 6028973 YP_001695454.1 CDS galU NC_010380.1 2084928 2085827 D identified by match to protein family HMM PF00483; match to protein family HMM TIGR01099; UTP-glucose-1-phosphate uridylyltransferase 2084928..2085827 Streptococcus pneumoniae Hungary19A-6 6027857 YP_001695455.1 CDS SPH_2282 NC_010380.1 2087484 2088161 R identified by match to protein family HMM PF01694; peptidase, S54 complement(2087484..2088161) Streptococcus pneumoniae Hungary19A-6 6028744 YP_001695456.1 CDS SPH_2283 NC_010380.1 2088145 2088684 R identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; 5-formyltetrahydrofolate cyclo-ligase complement(2088145..2088684) Streptococcus pneumoniae Hungary19A-6 6028554 YP_001695457.1 CDS SPH_2284 NC_010380.1 2088696 2089826 R identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01891; M20/M25/M40 family peptidase complement(2088696..2089826) Streptococcus pneumoniae Hungary19A-6 6028202 YP_001695458.1 CDS SPH_2285 NC_010380.1 2089894 2090592 R identified by match to protein family HMM PF00132; match to protein family HMM PF08503; galactoside O-acetyltransferase complement(2089894..2090592) Streptococcus pneumoniae Hungary19A-6 6029794 YP_001695459.1 CDS SPH_2286 NC_010380.1 2090822 2091733 R identified by match to protein family HMM PF00892; membrane protein complement(2090822..2091733) Streptococcus pneumoniae Hungary19A-6 6029937 YP_001695460.1 CDS SPH_2287 NC_010380.1 2091798 2094263 R identified by match to protein family HMM PF00905; match to protein family HMM PF00912; penicillin-binding protein 1B complement(2091798..2094263) Streptococcus pneumoniae Hungary19A-6 6029643 YP_001695461.1 CDS tyrS NC_010380.1 2094405 2095661 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 2094405..2095661 Streptococcus pneumoniae Hungary19A-6 6027740 YP_001695462.1 CDS SPH_2289 NC_010380.1 2095739 2097802 R identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01525; P-type ATPase-metal/cation transport complement(2095739..2097802) Streptococcus pneumoniae Hungary19A-6 6029514 YP_001695463.1 CDS SPH_2290 NC_010380.1 2097804 2098082 R hypothetical protein complement(2097804..2098082) Streptococcus pneumoniae Hungary19A-6 6029617 YP_001695464.1 CDS SPH_2291 NC_010380.1 2098234 2099082 D identified by match to protein family HMM PF08241; rRNA 2098234..2099082 Streptococcus pneumoniae Hungary19A-6 6027802 YP_001695465.1 CDS SPH_2294 NC_010380.1 2100671 2100826 R identified by glimmer; hypothetical protein complement(2100671..2100826) Streptococcus pneumoniae Hungary19A-6 6028748 YP_001695466.1 CDS SPH_2295 NC_010380.1 2101543 2103801 R identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093; glycogen phosphorylase complement(2101543..2103801) Streptococcus pneumoniae Hungary19A-6 6029605 YP_001695467.1 CDS malQ NC_010380.1 2103827 2105344 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(2103827..2105344) Streptococcus pneumoniae Hungary19A-6 6029179 YP_001695468.1 CDS SPH_2297 NC_010380.1 2106011 2107282 D identified by match to protein family HMM PF01547; maltose/maltodextrin-binding protein 2106011..2107282 Streptococcus pneumoniae Hungary19A-6 6030005 YP_001695469.1 CDS SPH_2298 NC_010380.1 2107393 2108685 D identified by match to protein family HMM PF00528; match to protein family HMM PF05154; maltodextrin transport system permease MalC 2107393..2108685 Streptococcus pneumoniae Hungary19A-6 6028030 YP_001695470.1 CDS SPH_2299 NC_010380.1 2108687 2109529 D identified by match to protein family HMM PF00528; ABC transporter membrane-spanning permease - maltose/maltodextrin 2108687..2109529 Streptococcus pneumoniae Hungary19A-6 6029264 YP_001695471.1 CDS SPH_2300 NC_010380.1 2109791 2110591 D maltodextrose utilization protein MalA 2109791..2110591 Streptococcus pneumoniae Hungary19A-6 6028188 YP_001695472.1 CDS SPH_2301 NC_010380.1 2110601 2111587 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; HTH-type transcriptional regulator MalR (maltose operontranscriptional repressor) 2110601..2111587 Streptococcus pneumoniae Hungary19A-6 6029276 YP_001695473.1 CDS SPH_2302 NC_010380.1 2111694 2112635 R identified by match to protein family HMM PF02588; hypothetical protein complement(2111694..2112635) Streptococcus pneumoniae Hungary19A-6 6029518 YP_001695474.1 CDS aspS NC_010380.1 2112613 2114376 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(2112613..2114376) Streptococcus pneumoniae Hungary19A-6 6027862 YP_001695475.1 CDS SPH_2305 NC_010380.1 2114817 2115047 R hypothetical protein complement(2114817..2115047) Streptococcus pneumoniae Hungary19A-6 6028723 YP_001695476.1 CDS SPH_2306 NC_010380.1 2115065 2115706 R identified by match to protein family HMM PF02517; CAAX amino protease complement(2115065..2115706) Streptococcus pneumoniae Hungary19A-6 6027810 YP_001695477.1 CDS SPH_2307 NC_010380.1 2115718 2116452 R hypothetical protein complement(2115718..2116452) Streptococcus pneumoniae Hungary19A-6 6028830 YP_001695478.1 CDS SPH_2308 NC_010380.1 2116455 2116652 R hypothetical protein complement(2116455..2116652) Streptococcus pneumoniae Hungary19A-6 6029257 YP_001695479.1 CDS SPH_2309 NC_010380.1 2116652 2116858 R identified by match to protein family HMM PF01381; hypothetical protein complement(2116652..2116858) Streptococcus pneumoniae Hungary19A-6 6027931 YP_001695480.1 CDS SPH_2310 NC_010380.1 2116868 2117182 R hypothetical protein complement(2116868..2117182) Streptococcus pneumoniae Hungary19A-6 6029180 YP_001695481.1 CDS SPH_2311 NC_010380.1 2117335 2117463 R chlorohydrolase complement(2117335..2117463) Streptococcus pneumoniae Hungary19A-6 6028892 YP_001695482.1 CDS hisS NC_010380.1 2117523 2118812 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(2117523..2118812) Streptococcus pneumoniae Hungary19A-6 6028492 YP_001695483.1 CDS SPH_2313 NC_010380.1 2118890 2120137 R hypothetical protein complement(2118890..2120137) Streptococcus pneumoniae Hungary19A-6 6029947 YP_001695484.1 CDS SPH_2314 NC_010380.1 2120328 2121179 R identified by match to protein family HMM TIGR01716; positive transcriptional regulator of glucosyltransferase and Spp phenotype complement(2120328..2121179) Streptococcus pneumoniae Hungary19A-6 6028570 YP_001695485.1 CDS SPH_2315 NC_010380.1 2121154 2121288 R hypothetical protein complement(2121154..2121288) Streptococcus pneumoniae Hungary19A-6 6027866 YP_001695486.1 CDS SPH_2316 NC_010380.1 2121303 2121644 D identified by match to protein family HMM PF01883; hypothetical protein 2121303..2121644 Streptococcus pneumoniae Hungary19A-6 6028924 YP_001695487.1 CDS ilvD NC_010380.1 2121943 2123646 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(2121943..2123646) Streptococcus pneumoniae Hungary19A-6 6029289 YP_001695488.1 CDS SPH_2319 NC_010380.1 2123879 2124811 R identified by match to protein family HMM PF02779; match to protein family HMM PF02780; transketolase, C- subunit complement(2123879..2124811) Streptococcus pneumoniae Hungary19A-6 6028546 YP_001695489.1 CDS SPH_2320 NC_010380.1 2124808 2125665 R identified by match to protein family HMM PF00456; transketolase complement(2124808..2125665) Streptococcus pneumoniae Hungary19A-6 6029415 YP_001695490.1 CDS ulaA NC_010380.1 2125669 2127015 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(2125669..2127015) Streptococcus pneumoniae Hungary19A-6 6028666 YP_001695491.1 CDS SPH_2322 NC_010380.1 2127028 2127312 R identified by match to protein family HMM PF02302; phosphotransferase system, galactitol-specific IIB component complement(2127028..2127312) Streptococcus pneumoniae Hungary19A-6 6029803 YP_001695492.1 CDS SPH_2323 NC_010380.1 2127316 2129346 R identified by match to protein family HMM PF00359; match to protein family HMM PF00874; transcriptional regulator, BglG family protein complement(2127316..2129346) Streptococcus pneumoniae Hungary19A-6 6028932 YP_001695493.1 CDS SPH_2324 NC_010380.1 2129537 2130544 D identified by match to protein family HMM PF01145; hypothetical protein 2129537..2130544 Streptococcus pneumoniae Hungary19A-6 6029159 YP_001695494.1 CDS SPH_2325 NC_010380.1 2130547 2130747 D hypothetical protein 2130547..2130747 Streptococcus pneumoniae Hungary19A-6 6028268 YP_001695495.1 CDS rpmF NC_010380.1 2130899 2131081 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 2130899..2131081 Streptococcus pneumoniae Hungary19A-6 6028825 YP_001695496.1 CDS rpmG NC_010380.1 2131097 2131246 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 2131097..2131246 Streptococcus pneumoniae Hungary19A-6 6029249 YP_001695497.1 CDS SPH_2328 NC_010380.1 2131738 2133663 R identified by match to protein family HMM PF01473; choline binding protein PcpA complement(2131738..2133663) Streptococcus pneumoniae Hungary19A-6 6029846 YP_001695498.1 CDS SPH_2332 NC_010380.1 2134835 2135110 R hypothetical protein complement(2134835..2135110) Streptococcus pneumoniae Hungary19A-6 6029902 YP_001695499.1 CDS SPH_2334 NC_010380.1 2135487 2137367 R identified by match to protein family HMM PF00728; N-acetyl-beta-D-glucosaminidase complement(2135487..2137367) Streptococcus pneumoniae Hungary19A-6 6027727 YP_001695500.1 CDS SPH_2335 NC_010380.1 2137361 2138230 R identified by match to protein family HMM PF00480; ROK family protein complement(2137361..2138230) Streptococcus pneumoniae Hungary19A-6 6028860 YP_001695501.1 CDS SPH_2336 NC_010380.1 2138314 2140950 R identified by match to protein family HMM PF01074; match to protein family HMM PF07748; sugar hydrolase complement(2138314..2140950) Streptococcus pneumoniae Hungary19A-6 6029059 YP_001695502.1 CDS SPH_2337 NC_010380.1 2141168 2142448 R identified by match to protein family HMM PF06824; twin-arginine translocation pathway signal complement(2141168..2142448) Streptococcus pneumoniae Hungary19A-6 6028758 YP_001695503.1 CDS SPH_2338 NC_010380.1 2142619 2144703 D identified by match to protein family HMM PF07971; match to protein family HMM TIGR01180; cell wall antigen 2142619..2144703 Streptococcus pneumoniae Hungary19A-6 6029853 YP_001695504.1 CDS SPH_2339 NC_010380.1 2144743 2146422 R FucA complement(2144743..2146422) Streptococcus pneumoniae Hungary19A-6 6028959 YP_001695505.1 CDS arcA NC_010380.1 2147177 2148406 D catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 2147177..2148406 Streptococcus pneumoniae Hungary19A-6 6028850 YP_001695506.1 CDS argF NC_010380.1 2148464 2149480 D catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 2148464..2149480 Streptococcus pneumoniae Hungary19A-6 6029516 YP_001695507.1 CDS arcC NC_010380.1 2149645 2150592 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 2149645..2150592 Streptococcus pneumoniae Hungary19A-6 6027962 YP_001695508.1 CDS SPH_2343 NC_010380.1 2150801 2152312 D identified by match to protein family HMM PF03606; arginine-ornithine antiporter 2150801..2152312 Streptococcus pneumoniae Hungary19A-6 6027822 YP_001695509.1 CDS SPH_2344 NC_010380.1 2152334 2153665 D identified by match to protein family HMM PF01546; match to protein family HMM TIGR01887; hypothetical protein 2152334..2153665 Streptococcus pneumoniae Hungary19A-6 6028941 YP_001695510.1 CDS SPH_2348 NC_010380.1 2154349 2154615 R identified by match to protein family HMM PF04650; match to protein family HMM TIGR01168; signal peptide, ysirk family protein complement(2154349..2154615) Streptococcus pneumoniae Hungary19A-6 6029458 YP_001695511.1 CDS SPH_2350 NC_010380.1 2155044 2155943 R identified by match to protein family HMM PF01145; SPFH domain-containing protein/band 7 family protein complement(2155044..2155943) Streptococcus pneumoniae Hungary19A-6 6029766 YP_001695512.1 CDS SPH_2351 NC_010380.1 2156073 2157224 R identified by match to protein family HMM PF00465; NAD-dependent methanol dehydrogenase (medh) complement(2156073..2157224) Streptococcus pneumoniae Hungary19A-6 6029062 YP_001695513.1 CDS fucI NC_010380.1 2157370 2159136 R catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase complement(2157370..2159136) Streptococcus pneumoniae Hungary19A-6 6027847 YP_001695514.1 CDS SPH_2353 NC_010380.1 2159193 2162309 R identified by match to protein family HMM PF00754; match to protein family HMM PF08306; match to protein family HMM PF08307; glycosy hydrolase complement(2159193..2162309) Streptococcus pneumoniae Hungary19A-6 6029608 YP_001695515.1 CDS SPH_2354 NC_010380.1 2162319 2164613 R large secreted protein complement(2162319..2164613) Streptococcus pneumoniae Hungary19A-6 6029253 YP_001695516.1 CDS SPH_2355 NC_010380.1 2164672 2165472 R pts system mannose-specific eiidcomponent; eiid-man; eii-m-man; identified by match to protein family HMM PF03613; mannose permease IID component complement(2164672..2165472) Streptococcus pneumoniae Hungary19A-6 6029260 YP_001695517.1 CDS SPH_2356 NC_010380.1 2165469 2166242 R identified by match to protein family HMM PF03609; phosphotransferase system sugar-specific EII component complement(2165469..2166242) Streptococcus pneumoniae Hungary19A-6 6029490 YP_001695518.1 CDS SPH_2357 NC_010380.1 2166256 2166735 R identified by match to protein family HMM PF03830; PTS system, IIB component complement(2166256..2166735) Streptococcus pneumoniae Hungary19A-6 6029598 YP_001695519.1 CDS SPH_2358 NC_010380.1 2166726 2167169 R identified by match to protein family HMM PF03610; PTS system, IIA component complement(2166726..2167169) Streptococcus pneumoniae Hungary19A-6 6028080 YP_001695520.1 CDS SPH_2359 NC_010380.1 2167150 2167590 R identified by match to protein family HMM PF05025; fucose operon FucU protein complement(2167150..2167590) Streptococcus pneumoniae Hungary19A-6 6028041 YP_001695521.1 CDS SPH_2360 NC_010380.1 2167602 2168240 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(2167602..2168240) Streptococcus pneumoniae Hungary19A-6 6027854 YP_001695522.1 CDS SPH_2361 NC_010380.1 2168355 2169758 R identified by match to protein family HMM PF00370; match to protein family HMM PF02782; rhamnulokinase (rhamnulose kinase) complement(2168355..2169758) Streptococcus pneumoniae Hungary19A-6 6029222 YP_001695523.1 CDS SPH_2362 NC_010380.1 2169934 2170707 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; regulator of fucose operon 2169934..2170707 Streptococcus pneumoniae Hungary19A-6 6028068 YP_001695524.1 CDS SPH_2363 NC_010380.1 2170852 2170980 R identified by glimmer; hypothetical protein complement(2170852..2170980) Streptococcus pneumoniae Hungary19A-6 6027759 YP_001695525.1 CDS SPH_2364 NC_010380.1 2171826 2173331 R identified by match to protein family HMM PF01297; match to protein family HMM PF09223; zinc-binding lipoprotein AdcA complement(2171826..2173331) Streptococcus pneumoniae Hungary19A-6 6028927 YP_001695526.1 CDS SPH_2365 NC_010380.1 2173341 2174147 R identified by match to protein family HMM PF00950; ABC transporter membrane-spanning permease - Zinc complement(2173341..2174147) Streptococcus pneumoniae Hungary19A-6 6030044 YP_001695527.1 CDS SPH_2366 NC_010380.1 2174140 2174844 R identified by match to protein family HMM PF00005; zinc transport system ATP-binding protein AdcC complement(2174140..2174844) Streptococcus pneumoniae Hungary19A-6 6029675 YP_001695528.1 CDS SPH_2367 NC_010380.1 2174844 2175284 R identified by match to protein family HMM PF01022; match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF01978; match to protein family HMM PF08279; transcriptional repressor complement(2174844..2175284) Streptococcus pneumoniae Hungary19A-6 6029168 YP_001695529.1 CDS SPH_2368 NC_010380.1 2175269 2175406 D hypothetical protein 2175269..2175406 Streptococcus pneumoniae Hungary19A-6 6029360 YP_001695530.1 CDS SPH_2369 NC_010380.1 2175439 2176707 R identified by match to protein family HMM PF04914; match to protein family HMM PF04915; match to protein family HMM PF04918; D-alanine transfer from undecaprenol-phosphate to the poly complement(2175439..2176707) Streptococcus pneumoniae Hungary19A-6 6028079 YP_001695531.1 CDS dltC NC_010380.1 2176700 2176939 R D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 complement(2176700..2176939) Streptococcus pneumoniae Hungary19A-6 6029166 YP_001695532.1 CDS SPH_2371 NC_010380.1 2176953 2178197 R identified by match to protein family HMM PF03062; protein DltB complement(2176953..2178197) Streptococcus pneumoniae Hungary19A-6 6030035 YP_001695533.1 CDS dltA NC_010380.1 2178194 2179744 R transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 complement(2178194..2179744) Streptococcus pneumoniae Hungary19A-6 6029811 YP_001695534.1 CDS SPH_2373 NC_010380.1 2179765 2179896 R hypothetical protein complement(2179765..2179896) Streptococcus pneumoniae Hungary19A-6 6028491 YP_001695535.1 CDS SPH_2374 NC_010380.1 2180210 2181115 R major facilitator superfamily permease complement(2180210..2181115) Streptococcus pneumoniae Hungary19A-6 6028471 YP_001695536.1 CDS SPH_2375 NC_010380.1 2181841 2183118 R identified by match to protein family HMM PF00078; match to protein family HMM PF08388; GBSi1, group II intron, maturase complement(2181841..2183118) Streptococcus pneumoniae Hungary19A-6 6028125 YP_001695537.1 CDS SPH_2376 NC_010380.1 2184227 2184814 D hypothetical protein 2184227..2184814 Streptococcus pneumoniae Hungary19A-6 6028572 YP_001695538.1 CDS SPH_2378 NC_010380.1 2185206 2185322 D identified by glimmer; hypothetical protein 2185206..2185322 Streptococcus pneumoniae Hungary19A-6 6028512 YP_001695539.1 CDS SPH_2379 NC_010380.1 2185401 2186105 R identified by match to protein family HMM PF00230; match to protein family HMM TIGR00861; glycerol uptake facilitator protein complement(2185401..2186105) Streptococcus pneumoniae Hungary19A-6 6028893 YP_001695540.1 CDS SPH_2380 NC_010380.1 2186180 2188006 R identified by match to protein family HMM PF01266; alpha-glycerophosphate oxidase complement(2186180..2188006) Streptococcus pneumoniae Hungary19A-6 6030068 YP_001695541.1 CDS glpK NC_010380.1 2188048 2189556 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(2188048..2189556) Streptococcus pneumoniae Hungary19A-6 6028946 YP_001695542.1 CDS SPH_2382 NC_010380.1 2189715 2191124 R identified by match to protein family HMM PF05043; M protein trans-acting positive regulator (MGA) complement(2189715..2191124) Streptococcus pneumoniae Hungary19A-6 6027947 YP_001695543.1 CDS hslO NC_010380.1 2191307 2192179 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 2191307..2192179 Streptococcus pneumoniae Hungary19A-6 6029657 YP_001695544.1 CDS SPH_2384 NC_010380.1 2192166 2193146 D identified by match to protein family HMM PF00724; match to protein family HMM PF01180; match to protein family HMM PF01207; match to protein family HMM TIGR00737; tRNA-dihydrouridine synthase B 2192166..2193146 Streptococcus pneumoniae Hungary19A-6 6029920 YP_001695545.1 CDS SPH_2385 NC_010380.1 2193365 2194708 R identified by match to protein family HMM PF00746; match to protein family HMM PF05062; match to protein family HMM TIGR01167; surface protein PspC complement(2193365..2194708) Streptococcus pneumoniae Hungary19A-6 6028910 YP_001695546.1 CDS SPH_2387 NC_010380.1 2195549 2196805 D identified by match to protein family HMM PF01610; transposase 2195549..2196805 Streptococcus pneumoniae Hungary19A-6 6028074 YP_001695547.1 CDS SPH_2388 NC_010380.1 2197008 2199110 R identified by match to protein family HMM PF01473; match to protein family HMM PF04650; match to protein family HMM PF05062; match to protein family HMM TIGR01168; surface protein PspC complement(2197008..2199110) Streptococcus pneumoniae Hungary19A-6 6029835 YP_001695548.1 CDS SPH_2389 NC_010380.1 2199189 2199716 R identified by match to protein family HMM PF04140; hypothetical protein complement(2199189..2199716) Streptococcus pneumoniae Hungary19A-6 6029987 YP_001695549.1 CDS SPH_2390 NC_010380.1 2199799 2201130 R identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; histidine kinase complement(2199799..2201130) Streptococcus pneumoniae Hungary19A-6 6028226 YP_001695550.1 CDS SPH_2391 NC_010380.1 2201127 2201780 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator complement(2201127..2201780) Streptococcus pneumoniae Hungary19A-6 6029297 YP_001695551.1 CDS SPH_2392 NC_010380.1 2201833 2202030 D identified by glimmer; hypothetical protein 2201833..2202030 Streptococcus pneumoniae Hungary19A-6 6029893 YP_001695552.1 CDS SPH_2393 NC_010380.1 2202101 2204533 R identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; chaperone ClpB 1 complement(2202101..2204533) Streptococcus pneumoniae Hungary19A-6 6029698 YP_001695553.1 CDS SPH_2394 NC_010380.1 2204535 2204993 R identified by match to protein family HMM PF05848; transcriptional regulator CtsR complement(2204535..2204993) Streptococcus pneumoniae Hungary19A-6 6028214 YP_001695554.1 CDS SPH_2395 NC_010380.1 2205112 2205840 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein - anion transport complement(2205112..2205840) Streptococcus pneumoniae Hungary19A-6 6028100 YP_001695555.1 CDS SPH_2396 NC_010380.1 2205840 2206847 R identified by match to protein family HMM PF09084; ABC transporter substrate-binding protein complement(2205840..2206847) Streptococcus pneumoniae Hungary19A-6 6028248 YP_001695556.1 CDS SPH_2397 NC_010380.1 2206886 2207647 R identified by match to protein family HMM PF00528; ABC transporter permease complement(2206886..2207647) Streptococcus pneumoniae Hungary19A-6 6028761 YP_001695557.1 CDS SPH_2398 NC_010380.1 2207607 2207897 R hypothetical protein complement(2207607..2207897) Streptococcus pneumoniae Hungary19A-6 6028105 YP_001695558.1 CDS SPH_2399 NC_010380.1 2208153 2209499 R identified by match to protein family HMM PF01473; match to protein family HMM PF05257; match to protein family HMM PF08460; choline binding protein D complement(2208153..2209499) Streptococcus pneumoniae Hungary19A-6 6029112 YP_001695559.1 CDS SPH_2400 NC_010380.1 2209588 2209854 R identified by match to protein family HMM PF06257; hypothetical protein complement(2209588..2209854) Streptococcus pneumoniae Hungary19A-6 6028598 YP_001695560.1 CDS dnaB NC_010380.1 2209856 2211208 R unwinds double stranded DNA; replicative DNA helicase complement(2209856..2211208) Streptococcus pneumoniae Hungary19A-6 6029088 YP_001695561.1 CDS rplI NC_010380.1 2211252 2211704 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(2211252..2211704) Streptococcus pneumoniae Hungary19A-6 6028577 YP_001695562.1 CDS SPH_2404 NC_010380.1 2213810 2214358 R identified by match to protein family HMM PF02482; match to protein family HMM TIGR00741; ribosome-associated protein Y complement(2213810..2214358) Streptococcus pneumoniae Hungary19A-6 6028944 YP_001695563.1 CDS SPH_2405 NC_010380.1 2214438 2215100 R transformation protein complement(2214438..2215100) Streptococcus pneumoniae Hungary19A-6 6030004 YP_001695564.1 CDS SPH_2406 NC_010380.1 2215097 2216395 R identified by match to protein family HMM PF00271; match to protein family HMM PF04851; superfamily II ATP-dependent DNA/RNA helicase complement(2215097..2216395) Streptococcus pneumoniae Hungary19A-6 6028415 YP_001695565.1 CDS SPH_2407 NC_010380.1 2216451 2217086 D identified by match to protein family HMM PF01205; match to protein family HMM TIGR00257; hypothetical protein 2216451..2217086 Streptococcus pneumoniae Hungary19A-6 6027923 YP_001695566.1 CDS cysK NC_010380.1 2217371 2218297 D identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; cysteine synthase A 2217371..2218297 Streptococcus pneumoniae Hungary19A-6 6028837 YP_001695567.1 CDS tsf NC_010380.1 2218418 2219458 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(2218418..2219458) Streptococcus pneumoniae Hungary19A-6 6028928 YP_001695568.1 CDS rpsB NC_010380.1 2219537 2220316 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(2219537..2220316) Streptococcus pneumoniae Hungary19A-6 6028530 YP_001695569.1 CDS SPH_2411 NC_010380.1 2220540 2221718 R identified by match to protein family HMM PF05257; general stress protein GSP-781 complement(2220540..2221718) Streptococcus pneumoniae Hungary19A-6 6028726 YP_001695570.1 CDS mreD NC_010380.1 2221799 2222305 R identified by match to protein family HMM PF04093; match to protein family HMM TIGR03426; rod shape-determining protein MreD complement(2221799..2222305) Streptococcus pneumoniae Hungary19A-6 6027901 YP_001695571.1 CDS mreC NC_010380.1 2222305 2223123 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(2222305..2223123) Streptococcus pneumoniae Hungary19A-6 6029140 YP_001695572.1 CDS SPH_2414 NC_010380.1 2223182 2223976 R identified by match to protein family HMM PF02361; ABC transporter permease complement(2223182..2223976) Streptococcus pneumoniae Hungary19A-6 6029336 YP_001695573.1 CDS cbiO NC_010380.1 2224792 2225619 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2224792..2225619) Streptococcus pneumoniae Hungary19A-6 6029204 YP_001695574.1 CDS pgsA NC_010380.1 2225616 2226161 R identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase complement(2225616..2226161) Streptococcus pneumoniae Hungary19A-6 6027814 YP_001695575.1 CDS SPH_2418 NC_010380.1 2226172 2226993 R hypothetical protein complement(2226172..2226993) Streptococcus pneumoniae Hungary19A-6 6028626 YP_001695576.1 CDS SPH_2419 NC_010380.1 2227035 2228318 R identified by match to protein family HMM PF00675; match to protein family HMM PF05193; M16 family peptidase complement(2227035..2228318) Streptococcus pneumoniae Hungary19A-6 6028325 YP_001695577.1 CDS SPH_2420 NC_010380.1 2228315 2229565 R identified by match to protein family HMM PF05193; M16 family peptidase complement(2228315..2229565) Streptococcus pneumoniae Hungary19A-6 6029848 YP_001695578.1 CDS SPH_2421 NC_010380.1 2229724 2230092 D identified by match to protein family HMM TIGR02988; S4 domain-containing protein YaaA 2229724..2230092 Streptococcus pneumoniae Hungary19A-6 6028727 YP_001695579.1 CDS recF NC_010380.1 2230095 2231192 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2230095..2231192 Streptococcus pneumoniae Hungary19A-6 6028902 YP_001695580.1 CDS guaB NC_010380.1 2231243 2232721 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2231243..2232721) Streptococcus pneumoniae Hungary19A-6 6028104 YP_001695581.1 CDS trpS NC_010380.1 2232873 2233898 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II complement(2232873..2233898) Streptococcus pneumoniae Hungary19A-6 6028734 YP_001695582.1 CDS SPH_2425 NC_010380.1 2234104 2235726 D identified by match to protein family HMM PF00005; ABC transporter ATPase 2234104..2235726 Streptococcus pneumoniae Hungary19A-6 6029753 YP_001695583.1 CDS SPH_2426 NC_010380.1 2235788 2238340 D ABC transporter permease component 2235788..2238340 Streptococcus pneumoniae Hungary19A-6 6030045 YP_001695584.1 CDS SPH_2429 NC_010380.1 2239654 2240196 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 2239654..2240196 Streptococcus pneumoniae Hungary19A-6 6028497 YP_001695585.1 CDS SPH_2432 NC_010380.1 2240439 2241191 R identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator complement(2240439..2241191) Streptococcus pneumoniae Hungary19A-6 6028371 YP_001695586.1 CDS SPH_2433 NC_010380.1 2241188 2242513 R identified by match to protein family HMM PF02518; ComD complement(2241188..2242513) Streptococcus pneumoniae Hungary19A-6 6028991 YP_001695587.1 CDS SPH_2434 NC_010380.1 2242534 2242659 R identified by match to protein family HMM PF03047; hypothetical protein complement(2242534..2242659) Streptococcus pneumoniae Hungary19A-6 6028708 YP_001695588.1 CDS SPH_2438 NC_010380.1 2243602 2244783 D identified by match to protein family HMM PF00089; trypsin domain-containing protein 2243602..2244783 Streptococcus pneumoniae Hungary19A-6 6028636 YP_001695589.1 CDS SPH_2439 NC_010380.1 2244841 2245599 D identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; stage 0 sporulation protein J 2244841..2245599 Streptococcus pneumoniae Hungary19A-6 6029634 SPH_0015 tRNA SPH_0015 NC_010380.1 15023 15097 D tRNA-Glu 15023..15097 Streptococcus pneumoniae Hungary19A-6 6028131 SPH_0017 tRNA SPH_0017 NC_010380.1 16943 17020 D tRNA-Ala 16943..17020 Streptococcus pneumoniae Hungary19A-6 6029022 SPH_0021 tRNA SPH_0021 NC_010380.1 20240 20316 D tRNA-Asn 20240..20316 Streptococcus pneumoniae Hungary19A-6 6028456 SPH_0961 tRNA SPH_0961 NC_010380.1 885700 885783 D tRNA-Tyr 885700..885783 Streptococcus pneumoniae Hungary19A-6 6029018 SPH_0962 tRNA SPH_0962 NC_010380.1 885790 885864 D tRNA-Gln 885790..885864 Streptococcus pneumoniae Hungary19A-6 6028845 SPH_0978 tRNA SPH_0978 NC_010380.1 900285 900377 R tRNA-Ser complement(900285..900377) Streptococcus pneumoniae Hungary19A-6 6028322 SPH_1115 tRNA SPH_1115 NC_010380.1 1027965 1028040 D tRNA-Thr 1027965..1028040 Streptococcus pneumoniae Hungary19A-6 6028594 SPH_1364 tRNA SPH_1364 NC_010380.1 1266683 1266759 R tRNA-Arg complement(1266683..1266759) Streptococcus pneumoniae Hungary19A-6 6028716 SPH_1434 tRNA SPH_1434 NC_010380.1 1330377 1330451 R tRNA-Arg complement(1330377..1330451) Streptococcus pneumoniae Hungary19A-6 6028162 SPH_1695 tRNA SPH_1695 NC_010380.1 1563504 1563594 R tRNA-Leu complement(1563504..1563594) Streptococcus pneumoniae Hungary19A-6 6029326 SPH_1908 tRNA SPH_1908 NC_010380.1 1774232 1774309 D tRNA-Lys 1774232..1774309 Streptococcus pneumoniae Hungary19A-6 6028836 SPH_2020 tRNA SPH_2020 NC_010380.1 1879643 1879735 R tRNA-Ser complement(1879643..1879735) Streptococcus pneumoniae Hungary19A-6 6028525 SPH_2021 tRNA SPH_2021 NC_010380.1 1879737 1879815 R tRNA-Ile complement(1879737..1879815) Streptococcus pneumoniae Hungary19A-6 6028515 SPH_2022 tRNA SPH_2022 NC_010380.1 1879847 1879920 R tRNA-Gly complement(1879847..1879920) Streptococcus pneumoniae Hungary19A-6 6028712 SPH_2023 tRNA SPH_2023 NC_010380.1 1879937 1880012 R tRNA-Phe complement(1879937..1880012) Streptococcus pneumoniae Hungary19A-6 6028002 SPH_2024 tRNA SPH_2024 NC_010380.1 1880013 1880089 R tRNA-Met complement(1880013..1880089) Streptococcus pneumoniae Hungary19A-6 6028561 SPH_2025 tRNA SPH_2025 NC_010380.1 1880100 1880192 R tRNA-Ser complement(1880100..1880192) Streptococcus pneumoniae Hungary19A-6 6028418 SPH_2026 tRNA SPH_2026 NC_010380.1 1880199 1880277 R tRNA-Met complement(1880199..1880277) Streptococcus pneumoniae Hungary19A-6 6028372 SPH_2027 tRNA SPH_2027 NC_010380.1 1880286 1880364 R tRNA-Met complement(1880286..1880364) Streptococcus pneumoniae Hungary19A-6 6027889 SPH_2028 tRNA SPH_2028 NC_010380.1 1880365 1880443 R tRNA-Pro complement(1880365..1880443) Streptococcus pneumoniae Hungary19A-6 6028787 SPH_2029 tRNA SPH_2029 NC_010380.1 1880455 1880531 R tRNA-Arg complement(1880455..1880531) Streptococcus pneumoniae Hungary19A-6 6028548 SPH_2030 tRNA SPH_2030 NC_010380.1 1880538 1880626 R tRNA-Leu complement(1880538..1880626) Streptococcus pneumoniae Hungary19A-6 6028361 SPH_2031 tRNA SPH_2031 NC_010380.1 1880631 1880705 R tRNA-Gly complement(1880631..1880705) Streptococcus pneumoniae Hungary19A-6 6028528 SPH_2032 tRNA SPH_2032 NC_010380.1 1880725 1880800 R tRNA-Thr complement(1880725..1880800) Streptococcus pneumoniae Hungary19A-6 6028732 SPH_2033 tRNA SPH_2033 NC_010380.1 1880815 1880901 R tRNA-Leu complement(1880815..1880901) Streptococcus pneumoniae Hungary19A-6 6028806 SPH_2034 tRNA SPH_2034 NC_010380.1 1880903 1880978 R tRNA-Lys complement(1880903..1880978) Streptococcus pneumoniae Hungary19A-6 6028052 SPH_2035 tRNA SPH_2035 NC_010380.1 1881000 1881150 R tRNA-Asp complement(1881000..1881150) Streptococcus pneumoniae Hungary19A-6 6028503 SPH_2039 tRNA SPH_2039 NC_010380.1 1884369 1884446 R tRNA-Ala complement(1884369..1884446) Streptococcus pneumoniae Hungary19A-6 6030043 SPH_2041 tRNA SPH_2041 NC_010380.1 1886292 1886366 R tRNA-Glu complement(1886292..1886366) Streptococcus pneumoniae Hungary19A-6 6029199 SPH_2103 tRNA SPH_2103 NC_010380.1 1942968 1943043 D tRNA-Cys 1942968..1943043 Streptococcus pneumoniae Hungary19A-6 6027706 SPH_2149 tRNA SPH_2149 NC_010380.1 1980797 1980875 R tRNA-Pro complement(1980797..1980875) Streptococcus pneumoniae Hungary19A-6 6029704 SPH_2150 tRNA SPH_2150 NC_010380.1 1980887 1980963 R tRNA-Arg complement(1980887..1980963) Streptococcus pneumoniae Hungary19A-6 6029491 SPH_2151 tRNA SPH_2151 NC_010380.1 1980970 1981058 R tRNA-Leu complement(1980970..1981058) Streptococcus pneumoniae Hungary19A-6 6028394 SPH_2152 tRNA SPH_2152 NC_010380.1 1981063 1981137 R tRNA-Gly complement(1981063..1981137) Streptococcus pneumoniae Hungary19A-6 6028657 SPH_2153 tRNA SPH_2153 NC_010380.1 1981157 1981232 R tRNA-Thr complement(1981157..1981232) Streptococcus pneumoniae Hungary19A-6 6028417 SPH_2154 tRNA SPH_2154 NC_010380.1 1981247 1981333 R tRNA-Leu complement(1981247..1981333) Streptococcus pneumoniae Hungary19A-6 6028508 SPH_2155 tRNA SPH_2155 NC_010380.1 1981335 1981410 R tRNA-Lys complement(1981335..1981410) Streptococcus pneumoniae Hungary19A-6 6029590 SPH_2156 tRNA SPH_2156 NC_010380.1 1981432 1981582 R tRNA-Asp complement(1981432..1981582) Streptococcus pneumoniae Hungary19A-6 6028607 SPH_2160 tRNA SPH_2160 NC_010380.1 1984801 1984878 R tRNA-Ala complement(1984801..1984878) Streptococcus pneumoniae Hungary19A-6 6029189 SPH_2162 tRNA SPH_2162 NC_010380.1 1986724 1986798 R tRNA-Glu complement(1986724..1986798) Streptococcus pneumoniae Hungary19A-6 6027902 SPH_2239 tRNA SPH_2239 NC_010380.1 2055032 2055120 R tRNA-Leu complement(2055032..2055120) Streptococcus pneumoniae Hungary19A-6 6028857 SPH_2240 tRNA SPH_2240 NC_010380.1 2055125 2055201 R tRNA-Gln complement(2055125..2055201) Streptococcus pneumoniae Hungary19A-6 6029023 SPH_2241 tRNA SPH_2241 NC_010380.1 2055210 2055287 R tRNA-His complement(2055210..2055287) Streptococcus pneumoniae Hungary19A-6 6028786 SPH_2242 tRNA SPH_2242 NC_010380.1 2055297 2055457 R tRNA-Trp complement(2055297..2055457) Streptococcus pneumoniae Hungary19A-6 6028884 SPH_2243 tRNA SPH_2243 NC_010380.1 2055466 2055541 R tRNA-Phe complement(2055466..2055541) Streptococcus pneumoniae Hungary19A-6 6028392 SPH_2244 tRNA SPH_2244 NC_010380.1 2055542 2055618 R tRNA-Met complement(2055542..2055618) Streptococcus pneumoniae Hungary19A-6 6028805 SPH_2245 tRNA SPH_2245 NC_010380.1 2055629 2055721 R tRNA-Ser complement(2055629..2055721) Streptococcus pneumoniae Hungary19A-6 6028566 SPH_2246 tRNA SPH_2246 NC_010380.1 2055800 2055878 R tRNA-Ile complement(2055800..2055878) Streptococcus pneumoniae Hungary19A-6 6028869 SPH_2247 tRNA SPH_2247 NC_010380.1 2055908 2055983 R tRNA-Gly complement(2055908..2055983) Streptococcus pneumoniae Hungary19A-6 6028848 SPH_2248 tRNA SPH_2248 NC_010380.1 2055985 2056060 R tRNA-Val complement(2055985..2056060) Streptococcus pneumoniae Hungary19A-6 6028560 SPH_2252 tRNA SPH_2252 NC_010380.1 2059279 2059356 R tRNA-Ala complement(2059279..2059356) Streptococcus pneumoniae Hungary19A-6 6028452 SPH_2254 tRNA SPH_2254 NC_010380.1 2061202 2061276 R tRNA-Glu complement(2061202..2061276) Streptococcus pneumoniae Hungary19A-6 6029206 SPH_2430 tRNA SPH_2430 NC_010380.1 2240234 2240310 R tRNA-Asn complement(2240234..2240310) Streptococcus pneumoniae Hungary19A-6 6029067 SPH_2431 tRNA SPH_2431 NC_010380.1 2240313 2240387 R tRNA-Glu complement(2240313..2240387) Streptococcus pneumoniae Hungary19A-6 6028945 SPH_2435 tRNA SPH_2435 NC_010380.1 2242821 2242897 R tRNA-Arg complement(2242821..2242897) Streptococcus pneumoniae Hungary19A-6 6028058 SPH_0016 rRNA rrs1 NC_010380.1 15372 16805 D 16S ribosomal RNA 15372..16805 Streptococcus pneumoniae Hungary19A-6 6028416 SPH_0019 rRNA rrl1 NC_010380.1 17141 20042 D 23S ribosomal RNA 17141..20042 Streptococcus pneumoniae Hungary19A-6 6028865 SPH_0020 rRNA rrf NC_010380.1 20119 20234 D 5S ribosomal RNA 20119..20234 Streptococcus pneumoniae Hungary19A-6 6028810 SPH_2036 rRNA rrf NC_010380.1 1881155 1881270 R 5S ribosomal RNA complement(1881155..1881270) Streptococcus pneumoniae Hungary19A-6 6028731 SPH_2037 rRNA rrl2 NC_010380.1 1881347 1884248 R 23S ribosomal RNA complement(1881347..1884248) Streptococcus pneumoniae Hungary19A-6 6029197 SPH_2040 rRNA rrs2 NC_010380.1 1884584 1886017 R 16S ribosomal RNA complement(1884584..1886017) Streptococcus pneumoniae Hungary19A-6 6028912 SPH_2157 rRNA rrf NC_010380.1 1981587 1981702 R 5S ribosomal RNA complement(1981587..1981702) Streptococcus pneumoniae Hungary19A-6 6028935 SPH_2158 rRNA rrl3 NC_010380.1 1981779 1984680 R 23S ribosomal RNA complement(1981779..1984680) Streptococcus pneumoniae Hungary19A-6 6028885 SPH_2161 rRNA rrs3 NC_010380.1 1985016 1986449 R 16S ribosomal RNA complement(1985016..1986449) Streptococcus pneumoniae Hungary19A-6 6028451 SPH_2249 rRNA rrf NC_010380.1 2056065 2056180 R 5S ribosomal RNA complement(2056065..2056180) Streptococcus pneumoniae Hungary19A-6 6028774 SPH_2250 rRNA rrl4 NC_010380.1 2056257 2059158 R 23S ribosomal RNA complement(2056257..2059158) Streptococcus pneumoniae Hungary19A-6 6030062 SPH_2253 rRNA rrs4 NC_010380.1 2059494 2060927 R 16S ribosomal RNA complement(2059494..2060927) Streptococcus pneumoniae Hungary19A-6 6028988