-- dump date   	20140620_084637
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
487214000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
487214000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214000003	Walker A motif; other site
487214000004	ATP binding site [chemical binding]; other site
487214000005	Walker B motif; other site
487214000006	arginine finger; other site
487214000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
487214000008	DnaA box-binding interface [nucleotide binding]; other site
487214000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
487214000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
487214000011	putative DNA binding surface [nucleotide binding]; other site
487214000012	dimer interface [polypeptide binding]; other site
487214000013	beta-clamp/clamp loader binding surface; other site
487214000014	beta-clamp/translesion DNA polymerase binding surface; other site
487214000015	Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864
487214000016	GTP-binding protein YchF; Reviewed; Region: PRK09601
487214000017	YchF GTPase; Region: YchF; cd01900
487214000018	G1 box; other site
487214000019	GTP/Mg2+ binding site [chemical binding]; other site
487214000020	Switch I region; other site
487214000021	G2 box; other site
487214000022	Switch II region; other site
487214000023	G3 box; other site
487214000024	G4 box; other site
487214000025	G5 box; other site
487214000026	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
487214000027	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
487214000028	putative active site [active]
487214000029	catalytic residue [active]
487214000030	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
487214000031	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
487214000032	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487214000033	ATP binding site [chemical binding]; other site
487214000034	putative Mg++ binding site [ion binding]; other site
487214000035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487214000036	nucleotide binding region [chemical binding]; other site
487214000037	ATP-binding site [chemical binding]; other site
487214000038	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
487214000039	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
487214000040	RNA binding surface [nucleotide binding]; other site
487214000041	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
487214000042	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
487214000043	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
487214000044	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
487214000045	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
487214000046	Ligand Binding Site [chemical binding]; other site
487214000047	TilS substrate C-terminal domain; Region: TilS_C; smart00977
487214000048	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487214000049	active site
487214000050	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
487214000051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214000052	Walker A motif; other site
487214000053	ATP binding site [chemical binding]; other site
487214000054	Walker B motif; other site
487214000055	arginine finger; other site
487214000056	Peptidase family M41; Region: Peptidase_M41; pfam01434
487214000057	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
487214000058	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
487214000059	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
487214000060	GDP-binding site [chemical binding]; other site
487214000061	ACT binding site; other site
487214000062	IMP binding site; other site
487214000063	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
487214000064	active site
487214000065	catalytic residues [active]
487214000066	DNA binding site [nucleotide binding]
487214000067	Int/Topo IB signature motif; other site
487214000068	HIRAN domain; Region: HIRAN; pfam08797
487214000069	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214000070	non-specific DNA binding site [nucleotide binding]; other site
487214000071	salt bridge; other site
487214000072	sequence-specific DNA binding site [nucleotide binding]; other site
487214000073	Predicted transcriptional regulator [Transcription]; Region: COG2932
487214000074	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
487214000075	Catalytic site [active]
487214000076	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
487214000077	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214000078	non-specific DNA binding site [nucleotide binding]; other site
487214000079	salt bridge; other site
487214000080	sequence-specific DNA binding site [nucleotide binding]; other site
487214000081	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
487214000082	Prophage antirepressor [Transcription]; Region: COG3617
487214000083	BRO family, N-terminal domain; Region: Bro-N; smart01040
487214000084	ORF6C domain; Region: ORF6C; pfam10552
487214000085	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
487214000086	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
487214000087	hypothetical protein; Validated; Region: PRK08116
487214000088	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214000089	Walker A motif; other site
487214000090	ATP binding site [chemical binding]; other site
487214000091	Walker B motif; other site
487214000092	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
487214000093	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
487214000094	Int/Topo IB signature motif; other site
487214000095	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487214000096	active site
487214000097	Phage Terminase; Region: Terminase_1; pfam03354
487214000098	Phage-related protein [Function unknown]; Region: COG4695; cl01923
487214000099	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
487214000100	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
487214000101	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
487214000102	Phage capsid family; Region: Phage_capsid; pfam05065
487214000103	Rab interacting lysosomal protein; Region: RILP; pfam11461
487214000104	Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488
487214000105	Centrosome localisation domain of Cep57; Region: Cep57_CLD; pfam14073
487214000106	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
487214000107	Phage-related minor tail protein [Function unknown]; Region: COG5280
487214000108	Phage-related protein [Function unknown]; Region: COG4722
487214000109	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
487214000110	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
487214000111	toxin secretion/phage lysis holin; Region: holin_tox_secr; TIGR01593
487214000112	Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682
487214000113	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
487214000114	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
487214000115	amidase catalytic site [active]
487214000116	Zn binding residues [ion binding]; other site
487214000117	substrate binding site [chemical binding]; other site
487214000118	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
487214000119	nucleoside/Zn binding site; other site
487214000120	dimer interface [polypeptide binding]; other site
487214000121	catalytic motif [active]
487214000122	Protein of unknown function (DUF3946); Region: DUF3946; pfam13102
487214000123	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
487214000124	Int/Topo IB signature motif; other site
487214000125	Domain of unknown function (DUF955); Region: DUF955; pfam06114
487214000126	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
487214000127	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214000128	non-specific DNA binding site [nucleotide binding]; other site
487214000129	salt bridge; other site
487214000130	sequence-specific DNA binding site [nucleotide binding]; other site
487214000131	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214000132	non-specific DNA binding site [nucleotide binding]; other site
487214000133	salt bridge; other site
487214000134	sequence-specific DNA binding site [nucleotide binding]; other site
487214000135	Phage anti-repressor protein [Transcription]; Region: COG3561
487214000136	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
487214000137	Helix-turn-helix domain; Region: HTH_36; pfam13730
487214000138	ERF superfamily; Region: ERF; pfam04404
487214000139	Protein of unknown function (DUF1351); Region: DUF1351; pfam07083
487214000140	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
487214000141	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
487214000142	dimer interface [polypeptide binding]; other site
487214000143	ssDNA binding site [nucleotide binding]; other site
487214000144	tetramer (dimer of dimers) interface [polypeptide binding]; other site
487214000145	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
487214000146	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
487214000147	cofactor binding site; other site
487214000148	DNA binding site [nucleotide binding]
487214000149	substrate interaction site [chemical binding]; other site
487214000150	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
487214000151	Endodeoxyribonuclease RusA; Region: RusA; cl01885
487214000152	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
487214000153	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
487214000154	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
487214000155	ParB-like nuclease domain; Region: ParBc; pfam02195
487214000156	Domain of unknown function (DUF4417); Region: DUF4417; pfam14386
487214000157	Phage terminase large subunit; Region: Terminase_3; cl12054
487214000158	Terminase-like family; Region: Terminase_6; pfam03237
487214000159	phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542
487214000160	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
487214000161	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
487214000162	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
487214000163	Minor capsid protein; Region: Minor_capsid_1; pfam10665
487214000164	Minor capsid protein; Region: Minor_capsid_2; pfam11114
487214000165	Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691
487214000166	Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854
487214000167	tape measure domain; Region: tape_meas_nterm; TIGR02675
487214000168	putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633
487214000169	Phage tail protein; Region: Sipho_tail; cl17486
487214000170	Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895
487214000171	Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895
487214000172	toxin secretion/phage lysis holin; Region: holin_tox_secr; TIGR01593
487214000173	Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890
487214000174	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
487214000175	trimer interface [polypeptide binding]; other site
487214000176	active site
487214000177	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487214000178	catalytic core [active]
487214000179	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
487214000180	DNA repair protein RadA; Provisional; Region: PRK11823
487214000181	Walker A motif; other site
487214000182	ATP binding site [chemical binding]; other site
487214000183	Walker B motif; other site
487214000184	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
487214000185	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
487214000186	active site clefts [active]
487214000187	zinc binding site [ion binding]; other site
487214000188	dimer interface [polypeptide binding]; other site
487214000189	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
487214000190	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
487214000191	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
487214000192	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487214000193	active site
487214000194	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
487214000195	DNA polymerase I; Provisional; Region: PRK05755
487214000196	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
487214000197	active site
487214000198	metal binding site 1 [ion binding]; metal-binding site
487214000199	putative 5' ssDNA interaction site; other site
487214000200	metal binding site 3; metal-binding site
487214000201	metal binding site 2 [ion binding]; metal-binding site
487214000202	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
487214000203	putative DNA binding site [nucleotide binding]; other site
487214000204	putative metal binding site [ion binding]; other site
487214000205	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
487214000206	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
487214000207	active site
487214000208	DNA binding site [nucleotide binding]
487214000209	catalytic site [active]
487214000210	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
487214000211	Predicted membrane protein [Function unknown]; Region: COG2855
487214000212	aromatic amino acid aminotransferase; Validated; Region: PRK07309
487214000213	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487214000214	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487214000215	homodimer interface [polypeptide binding]; other site
487214000216	catalytic residue [active]
487214000217	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
487214000218	Recombination protein O N terminal; Region: RecO_N; pfam11967
487214000219	Recombination protein O C terminal; Region: RecO_C; pfam02565
487214000220	putative phosphate acyltransferase; Provisional; Region: PRK05331
487214000221	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
487214000222	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
487214000223	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214000224	non-specific DNA binding site [nucleotide binding]; other site
487214000225	salt bridge; other site
487214000226	sequence-specific DNA binding site [nucleotide binding]; other site
487214000227	Bacteriocin class IId cyclical uberolysin-like; Region: Bacteriocin_IId; pfam09221
487214000228	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214000229	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
487214000230	Walker A/P-loop; other site
487214000231	ATP binding site [chemical binding]; other site
487214000232	Q-loop/lid; other site
487214000233	ABC transporter signature motif; other site
487214000234	Walker B; other site
487214000235	D-loop; other site
487214000236	H-loop/switch region; other site
487214000237	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
487214000238	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
487214000239	putative active site [active]
487214000240	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
487214000241	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214000242	Walker A/P-loop; other site
487214000243	ATP binding site [chemical binding]; other site
487214000244	Q-loop/lid; other site
487214000245	ABC transporter signature motif; other site
487214000246	Walker B; other site
487214000247	D-loop; other site
487214000248	H-loop/switch region; other site
487214000249	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
487214000250	HlyD family secretion protein; Region: HlyD_3; pfam13437
487214000251	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
487214000252	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
487214000253	ATP binding site [chemical binding]; other site
487214000254	active site
487214000255	substrate binding site [chemical binding]; other site
487214000256	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
487214000257	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
487214000258	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
487214000259	dimerization interface [polypeptide binding]; other site
487214000260	ATP binding site [chemical binding]; other site
487214000261	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
487214000262	dimerization interface [polypeptide binding]; other site
487214000263	ATP binding site [chemical binding]; other site
487214000264	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
487214000265	putative active site [active]
487214000266	catalytic triad [active]
487214000267	amidophosphoribosyltransferase; Provisional; Region: PRK07272
487214000268	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
487214000269	active site
487214000270	tetramer interface [polypeptide binding]; other site
487214000271	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487214000272	active site
487214000273	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
487214000274	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
487214000275	dimerization interface [polypeptide binding]; other site
487214000276	putative ATP binding site [chemical binding]; other site
487214000277	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
487214000278	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
487214000279	active site
487214000280	substrate binding site [chemical binding]; other site
487214000281	cosubstrate binding site; other site
487214000282	catalytic site [active]
487214000283	VanZ like family; Region: VanZ; pfam04892
487214000284	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
487214000285	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
487214000286	purine monophosphate binding site [chemical binding]; other site
487214000287	dimer interface [polypeptide binding]; other site
487214000288	putative catalytic residues [active]
487214000289	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
487214000290	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
487214000291	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
487214000292	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
487214000293	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
487214000294	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
487214000295	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
487214000296	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
487214000297	ATP-grasp domain; Region: ATP-grasp; pfam02222
487214000298	adenylosuccinate lyase; Provisional; Region: PRK07492
487214000299	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
487214000300	tetramer interface [polypeptide binding]; other site
487214000301	active site
487214000302	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
487214000303	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
487214000304	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
487214000305	active site
487214000306	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
487214000307	active site
487214000308	G5 domain; Region: G5; pfam07501
487214000309	G5 domain; Region: G5; pfam07501
487214000310	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
487214000311	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487214000312	DNA-binding site [nucleotide binding]; DNA binding site
487214000313	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
487214000314	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
487214000315	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
487214000316	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
487214000317	active site
487214000318	phosphorylation site [posttranslational modification]
487214000319	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
487214000320	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
487214000321	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
487214000322	active pocket/dimerization site; other site
487214000323	active site
487214000324	phosphorylation site [posttranslational modification]
487214000325	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
487214000326	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
487214000327	dimer interface [polypeptide binding]; other site
487214000328	active site
487214000329	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
487214000330	putative active site [active]
487214000331	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
487214000332	active site
487214000333	catalytic residues [active]
487214000334	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
487214000335	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
487214000336	putative metal binding site [ion binding]; other site
487214000337	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
487214000338	active site
487214000339	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
487214000340	putative homodimer interface [polypeptide binding]; other site
487214000341	putative homotetramer interface [polypeptide binding]; other site
487214000342	putative metal binding site [ion binding]; other site
487214000343	putative homodimer-homodimer interface [polypeptide binding]; other site
487214000344	putative allosteric switch controlling residues; other site
487214000345	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
487214000346	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
487214000347	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
487214000348	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
487214000349	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
487214000350	TrkA-N domain; Region: TrkA_N; pfam02254
487214000351	Fibronectin-binding repeat; Region: SSURE; pfam11966
487214000352	Fibronectin-binding repeat; Region: SSURE; pfam11966
487214000353	Fibronectin-binding repeat; Region: SSURE; pfam11966
487214000354	Fibronectin-binding repeat; Region: SSURE; pfam11966
487214000355	Fibronectin-binding repeat; Region: SSURE; pfam11966
487214000356	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487214000357	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487214000358	active site
487214000359	phosphorylation site [posttranslational modification]
487214000360	intermolecular recognition site; other site
487214000361	dimerization interface [polypeptide binding]; other site
487214000362	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487214000363	DNA binding site [nucleotide binding]
487214000364	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487214000365	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
487214000366	dimerization interface [polypeptide binding]; other site
487214000367	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487214000368	dimer interface [polypeptide binding]; other site
487214000369	phosphorylation site [posttranslational modification]
487214000370	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214000371	ATP binding site [chemical binding]; other site
487214000372	Mg2+ binding site [ion binding]; other site
487214000373	G-X-G motif; other site
487214000374	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
487214000375	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
487214000376	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
487214000377	RNA binding surface [nucleotide binding]; other site
487214000378	Helix-turn-helix domain; Region: HTH_28; pfam13518
487214000379	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
487214000380	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214000381	dimer interface [polypeptide binding]; other site
487214000382	conserved gate region; other site
487214000383	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
487214000384	ABC-ATPase subunit interface; other site
487214000385	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
487214000386	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214000387	dimer interface [polypeptide binding]; other site
487214000388	conserved gate region; other site
487214000389	putative PBP binding loops; other site
487214000390	ABC-ATPase subunit interface; other site
487214000391	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
487214000392	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
487214000393	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
487214000394	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
487214000395	active site residue [active]
487214000396	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
487214000397	Domain of unknown function (DUF4299); Region: DUF4299; pfam14132
487214000398	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
487214000399	Predicted membrane protein [Function unknown]; Region: COG4709
487214000400	Predicted transcriptional regulators [Transcription]; Region: COG1695
487214000401	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
487214000402	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
487214000403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487214000404	putative substrate translocation pore; other site
487214000405	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
487214000406	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
487214000407	Ligand binding site; other site
487214000408	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
487214000409	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
487214000410	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
487214000411	NAD(P) binding site [chemical binding]; other site
487214000412	homodimer interface [polypeptide binding]; other site
487214000413	substrate binding site [chemical binding]; other site
487214000414	active site
487214000415	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
487214000416	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214000417	active site
487214000418	motif I; other site
487214000419	motif II; other site
487214000420	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
487214000421	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
487214000422	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
487214000423	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
487214000424	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
487214000425	putative L-serine binding site [chemical binding]; other site
487214000426	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
487214000427	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
487214000428	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
487214000429	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214000430	non-specific DNA binding site [nucleotide binding]; other site
487214000431	salt bridge; other site
487214000432	sequence-specific DNA binding site [nucleotide binding]; other site
487214000433	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683
487214000434	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
487214000435	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
487214000436	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
487214000437	Walker A/P-loop; other site
487214000438	ATP binding site [chemical binding]; other site
487214000439	Q-loop/lid; other site
487214000440	ABC transporter signature motif; other site
487214000441	Walker B; other site
487214000442	D-loop; other site
487214000443	H-loop/switch region; other site
487214000444	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
487214000445	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
487214000446	substrate binding pocket [chemical binding]; other site
487214000447	membrane-bound complex binding site; other site
487214000448	hinge residues; other site
487214000449	argininosuccinate synthase; Provisional; Region: PRK13820
487214000450	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
487214000451	ANP binding site [chemical binding]; other site
487214000452	Substrate Binding Site II [chemical binding]; other site
487214000453	Substrate Binding Site I [chemical binding]; other site
487214000454	argininosuccinate lyase; Provisional; Region: PRK00855
487214000455	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
487214000456	active sites [active]
487214000457	tetramer interface [polypeptide binding]; other site
487214000458	CRISPR/Cas system-associated protein Csn2; Region: Csn2_like; cl09913
487214000459	tetramer interface [polypeptide binding]; other site
487214000460	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214000461	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
487214000462	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214000463	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214000464	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214000465	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214000466	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214000467	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214000468	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
487214000469	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214000470	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214000471	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
487214000472	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
487214000473	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
487214000474	nudix motif; other site
487214000475	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
487214000476	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
487214000477	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
487214000478	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
487214000479	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
487214000480	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
487214000481	hypothetical protein; Provisional; Region: PRK13667
487214000482	class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949
487214000483	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
487214000484	Glycoprotease family; Region: Peptidase_M22; pfam00814
487214000485	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
487214000486	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487214000487	Coenzyme A binding pocket [chemical binding]; other site
487214000488	UGMP family protein; Validated; Region: PRK09604
487214000489	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
487214000490	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
487214000491	Winged helix-turn helix; Region: HTH_33; pfam13592
487214000492	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487214000493	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
487214000494	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
487214000495	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
487214000496	active site
487214000497	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
487214000498	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
487214000499	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
487214000500	Walker A/P-loop; other site
487214000501	ATP binding site [chemical binding]; other site
487214000502	Q-loop/lid; other site
487214000503	ABC transporter signature motif; other site
487214000504	Walker B; other site
487214000505	D-loop; other site
487214000506	H-loop/switch region; other site
487214000507	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
487214000508	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
487214000509	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
487214000510	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
487214000511	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
487214000512	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214000513	non-specific DNA binding site [nucleotide binding]; other site
487214000514	salt bridge; other site
487214000515	sequence-specific DNA binding site [nucleotide binding]; other site
487214000516	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
487214000517	CAAX protease self-immunity; Region: Abi; pfam02517
487214000518	H+ Antiporter protein; Region: 2A0121; TIGR00900
487214000519	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
487214000520	Predicted membrane protein [Function unknown]; Region: COG4392
487214000521	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
487214000522	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
487214000523	substrate binding pocket [chemical binding]; other site
487214000524	membrane-bound complex binding site; other site
487214000525	hinge residues; other site
487214000526	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
487214000527	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
487214000528	hypothetical protein; Provisional; Region: PRK06446
487214000529	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
487214000530	metal binding site [ion binding]; metal-binding site
487214000531	dimer interface [polypeptide binding]; other site
487214000532	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
487214000533	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
487214000534	Walker A/P-loop; other site
487214000535	ATP binding site [chemical binding]; other site
487214000536	Q-loop/lid; other site
487214000537	ABC transporter signature motif; other site
487214000538	Walker B; other site
487214000539	D-loop; other site
487214000540	H-loop/switch region; other site
487214000541	NIL domain; Region: NIL; pfam09383
487214000542	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
487214000543	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
487214000544	Predicted integral membrane protein [Function unknown]; Region: COG5578
487214000545	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
487214000546	HAMP domain; Region: HAMP; pfam00672
487214000547	Histidine kinase; Region: His_kinase; pfam06580
487214000548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214000549	ATP binding site [chemical binding]; other site
487214000550	Mg2+ binding site [ion binding]; other site
487214000551	G-X-G motif; other site
487214000552	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
487214000553	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487214000554	active site
487214000555	phosphorylation site [posttranslational modification]
487214000556	intermolecular recognition site; other site
487214000557	dimerization interface [polypeptide binding]; other site
487214000558	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487214000559	flavoprotein NrdI; Provisional; Region: PRK02551
487214000560	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
487214000561	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
487214000562	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
487214000563	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
487214000564	LytTr DNA-binding domain; Region: LytTR; smart00850
487214000565	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
487214000566	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214000567	ATP binding site [chemical binding]; other site
487214000568	Mg2+ binding site [ion binding]; other site
487214000569	G-X-G motif; other site
487214000570	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
487214000571	ATP binding site [chemical binding]; other site
487214000572	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
487214000573	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
487214000574	homopentamer interface [polypeptide binding]; other site
487214000575	active site
487214000576	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
487214000577	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
487214000578	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
487214000579	dimerization interface [polypeptide binding]; other site
487214000580	active site
487214000581	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
487214000582	Lumazine binding domain; Region: Lum_binding; pfam00677
487214000583	Lumazine binding domain; Region: Lum_binding; pfam00677
487214000584	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
487214000585	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
487214000586	catalytic motif [active]
487214000587	Zn binding site [ion binding]; other site
487214000588	RibD C-terminal domain; Region: RibD_C; cl17279
487214000589	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
487214000590	RuvA N terminal domain; Region: RuvA_N; pfam01330
487214000591	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
487214000592	CAAX protease self-immunity; Region: Abi; pfam02517
487214000593	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
487214000594	putative dimer interface [polypeptide binding]; other site
487214000595	catalytic triad [active]
487214000596	Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858
487214000597	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
487214000598	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
487214000599	Cl binding site [ion binding]; other site
487214000600	oligomer interface [polypeptide binding]; other site
487214000601	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
487214000602	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
487214000603	Int/Topo IB signature motif; other site
487214000604	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
487214000605	Divergent AAA domain; Region: AAA_4; pfam04326
487214000606	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
487214000607	Penicillinase repressor; Region: Pencillinase_R; cl17580
487214000608	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214000609	non-specific DNA binding site [nucleotide binding]; other site
487214000610	salt bridge; other site
487214000611	sequence-specific DNA binding site [nucleotide binding]; other site
487214000612	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214000613	sequence-specific DNA binding site [nucleotide binding]; other site
487214000614	salt bridge; other site
487214000615	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
487214000616	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
487214000617	Preprotein translocase subunit; Region: YajC; cl00806
487214000618	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
487214000619	D5 N terminal like; Region: D5_N; smart00885
487214000620	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
487214000621	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
487214000622	Protein of unknown function (DUF1492); Region: DUF1492; pfam07374
487214000623	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
487214000624	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
487214000625	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
487214000626	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
487214000627	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
487214000628	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
487214000629	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
487214000630	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
487214000631	active site
487214000632	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
487214000633	ArsC family; Region: ArsC; pfam03960
487214000634	putative catalytic residues [active]
487214000635	thiol/disulfide switch; other site
487214000636	hypothetical protein; Provisional; Region: PRK05473
487214000637	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
487214000638	hypothetical protein; Provisional; Region: PRK13678
487214000639	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
487214000640	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
487214000641	Bacterial lipoprotein; Region: DUF3642; pfam12182
487214000642	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
487214000643	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
487214000644	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
487214000645	putative active site [active]
487214000646	catalytic site [active]
487214000647	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
487214000648	putative active site [active]
487214000649	catalytic site [active]
487214000650	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
487214000651	ATP cone domain; Region: ATP-cone; pfam03477
487214000652	Class III ribonucleotide reductase; Region: RNR_III; cd01675
487214000653	effector binding site; other site
487214000654	active site
487214000655	Zn binding site [ion binding]; other site
487214000656	glycine loop; other site
487214000657	Predicted acetyltransferase [General function prediction only]; Region: COG3981
487214000658	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
487214000659	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
487214000660	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
487214000661	FeS/SAM binding site; other site
487214000662	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
487214000663	active site
487214000664	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
487214000665	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
487214000666	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
487214000667	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
487214000668	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
487214000669	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
487214000670	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
487214000671	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
487214000672	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
487214000673	putative translocon binding site; other site
487214000674	protein-rRNA interface [nucleotide binding]; other site
487214000675	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
487214000676	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
487214000677	G-X-X-G motif; other site
487214000678	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
487214000679	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
487214000680	23S rRNA interface [nucleotide binding]; other site
487214000681	5S rRNA interface [nucleotide binding]; other site
487214000682	putative antibiotic binding site [chemical binding]; other site
487214000683	L25 interface [polypeptide binding]; other site
487214000684	L27 interface [polypeptide binding]; other site
487214000685	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
487214000686	23S rRNA interface [nucleotide binding]; other site
487214000687	putative translocon interaction site; other site
487214000688	signal recognition particle (SRP54) interaction site; other site
487214000689	L23 interface [polypeptide binding]; other site
487214000690	trigger factor interaction site; other site
487214000691	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
487214000692	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
487214000693	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
487214000694	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
487214000695	RNA binding site [nucleotide binding]; other site
487214000696	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
487214000697	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
487214000698	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
487214000699	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
487214000700	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
487214000701	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
487214000702	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
487214000703	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
487214000704	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
487214000705	5S rRNA interface [nucleotide binding]; other site
487214000706	L27 interface [polypeptide binding]; other site
487214000707	23S rRNA interface [nucleotide binding]; other site
487214000708	L5 interface [polypeptide binding]; other site
487214000709	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
487214000710	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
487214000711	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
487214000712	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
487214000713	23S rRNA binding site [nucleotide binding]; other site
487214000714	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
487214000715	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
487214000716	SecY translocase; Region: SecY; pfam00344
487214000717	adenylate kinase; Reviewed; Region: adk; PRK00279
487214000718	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
487214000719	AMP-binding site [chemical binding]; other site
487214000720	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
487214000721	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
487214000722	rRNA binding site [nucleotide binding]; other site
487214000723	predicted 30S ribosome binding site; other site
487214000724	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
487214000725	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
487214000726	30S ribosomal protein S13; Region: bact_S13; TIGR03631
487214000727	30S ribosomal protein S11; Validated; Region: PRK05309
487214000728	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
487214000729	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
487214000730	alphaNTD homodimer interface [polypeptide binding]; other site
487214000731	alphaNTD - beta interaction site [polypeptide binding]; other site
487214000732	alphaNTD - beta' interaction site [polypeptide binding]; other site
487214000733	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
487214000734	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
487214000735	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
487214000736	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
487214000737	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487214000738	catalytic core [active]
487214000739	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
487214000740	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214000741	Walker A/P-loop; other site
487214000742	ATP binding site [chemical binding]; other site
487214000743	Q-loop/lid; other site
487214000744	ABC transporter signature motif; other site
487214000745	Walker B; other site
487214000746	D-loop; other site
487214000747	H-loop/switch region; other site
487214000748	TOBE domain; Region: TOBE_2; pfam08402
487214000749	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
487214000750	Mg2+ binding site [ion binding]; other site
487214000751	G-X-G motif; other site
487214000752	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
487214000753	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
487214000754	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
487214000755	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
487214000756	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
487214000757	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
487214000758	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
487214000759	active site
487214000760	methionine cluster; other site
487214000761	phosphorylation site [posttranslational modification]
487214000762	metal binding site [ion binding]; metal-binding site
487214000763	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
487214000764	active site
487214000765	P-loop; other site
487214000766	phosphorylation site [posttranslational modification]
487214000767	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
487214000768	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
487214000769	Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882
487214000770	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
487214000771	dimer interface [polypeptide binding]; other site
487214000772	active site
487214000773	glycine loop; other site
487214000774	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
487214000775	active site
487214000776	intersubunit interactions; other site
487214000777	catalytic residue [active]
487214000778	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
487214000779	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
487214000780	dimer interface [polypeptide binding]; other site
487214000781	active site
487214000782	metal binding site [ion binding]; metal-binding site
487214000783	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
487214000784	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
487214000785	HIGH motif; other site
487214000786	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
487214000787	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
487214000788	active site
487214000789	KMSKS motif; other site
487214000790	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
487214000791	tRNA binding surface [nucleotide binding]; other site
487214000792	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
487214000793	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
487214000794	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
487214000795	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487214000796	Coenzyme A binding pocket [chemical binding]; other site
487214000797	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
487214000798	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214000799	Walker A motif; other site
487214000800	ATP binding site [chemical binding]; other site
487214000801	Walker B motif; other site
487214000802	arginine finger; other site
487214000803	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
487214000804	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575
487214000805	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
487214000806	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
487214000807	catalytic residue [active]
487214000808	putative FPP diphosphate  binding site; other site
487214000809	putative FPP binding hydrophobic cleft; other site
487214000810	dimer interface [polypeptide binding]; other site
487214000811	putative IPP diphosphate binding site; other site
487214000812	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
487214000813	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
487214000814	RIP metalloprotease RseP; Region: TIGR00054
487214000815	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
487214000816	active site
487214000817	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
487214000818	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
487214000819	putative substrate binding region [chemical binding]; other site
487214000820	prolyl-tRNA synthetase; Provisional; Region: PRK09194
487214000821	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
487214000822	dimer interface [polypeptide binding]; other site
487214000823	motif 1; other site
487214000824	active site
487214000825	motif 2; other site
487214000826	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
487214000827	putative deacylase active site [active]
487214000828	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
487214000829	active site
487214000830	motif 3; other site
487214000831	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
487214000832	anticodon binding site; other site
487214000833	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
487214000834	beta-galactosidase; Region: BGL; TIGR03356
487214000835	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
487214000836	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
487214000837	glutaminase active site [active]
487214000838	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
487214000839	dimer interface [polypeptide binding]; other site
487214000840	active site
487214000841	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
487214000842	dimer interface [polypeptide binding]; other site
487214000843	active site
487214000844	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
487214000845	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
487214000846	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
487214000847	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
487214000848	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
487214000849	carbohydrate binding site [chemical binding]; other site
487214000850	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
487214000851	carbohydrate binding site [chemical binding]; other site
487214000852	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
487214000853	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
487214000854	Ca binding site [ion binding]; other site
487214000855	active site
487214000856	catalytic site [active]
487214000857	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
487214000858	S17 interaction site [polypeptide binding]; other site
487214000859	S8 interaction site; other site
487214000860	16S rRNA interaction site [nucleotide binding]; other site
487214000861	streptomycin interaction site [chemical binding]; other site
487214000862	23S rRNA interaction site [nucleotide binding]; other site
487214000863	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
487214000864	30S ribosomal protein S7; Validated; Region: PRK05302
487214000865	elongation factor G; Reviewed; Region: PRK00007
487214000866	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
487214000867	G1 box; other site
487214000868	putative GEF interaction site [polypeptide binding]; other site
487214000869	GTP/Mg2+ binding site [chemical binding]; other site
487214000870	Switch I region; other site
487214000871	G2 box; other site
487214000872	G3 box; other site
487214000873	Switch II region; other site
487214000874	G4 box; other site
487214000875	G5 box; other site
487214000876	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
487214000877	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
487214000878	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
487214000879	DNA polymerase III PolC; Validated; Region: polC; PRK00448
487214000880	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
487214000881	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
487214000882	generic binding surface II; other site
487214000883	generic binding surface I; other site
487214000884	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
487214000885	active site
487214000886	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
487214000887	active site
487214000888	catalytic site [active]
487214000889	substrate binding site [chemical binding]; other site
487214000890	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
487214000891	putative PHP Thumb interface [polypeptide binding]; other site
487214000892	active site
487214000893	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
487214000894	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
487214000895	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
487214000896	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
487214000897	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
487214000898	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
487214000899	active site
487214000900	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
487214000901	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
487214000902	RNA binding surface [nucleotide binding]; other site
487214000903	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
487214000904	active site
487214000905	uracil binding [chemical binding]; other site
487214000906	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
487214000907	trimer interface [polypeptide binding]; other site
487214000908	active site
487214000909	G bulge; other site
487214000910	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
487214000911	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
487214000912	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
487214000913	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
487214000914	active pocket/dimerization site; other site
487214000915	active site
487214000916	phosphorylation site [posttranslational modification]
487214000917	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
487214000918	active site
487214000919	phosphorylation site [posttranslational modification]
487214000920	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
487214000921	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
487214000922	NAD binding site [chemical binding]; other site
487214000923	substrate binding site [chemical binding]; other site
487214000924	catalytic Zn binding site [ion binding]; other site
487214000925	tetramer interface [polypeptide binding]; other site
487214000926	structural Zn binding site [ion binding]; other site
487214000927	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
487214000928	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214000929	active site
487214000930	motif I; other site
487214000931	motif II; other site
487214000932	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
487214000933	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
487214000934	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
487214000935	dihydropteroate synthase; Region: DHPS; TIGR01496
487214000936	substrate binding pocket [chemical binding]; other site
487214000937	dimer interface [polypeptide binding]; other site
487214000938	inhibitor binding site; inhibition site
487214000939	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
487214000940	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
487214000941	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
487214000942	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
487214000943	homodecamer interface [polypeptide binding]; other site
487214000944	GTP cyclohydrolase I; Provisional; Region: PLN03044
487214000945	active site
487214000946	putative catalytic site residues [active]
487214000947	zinc binding site [ion binding]; other site
487214000948	GTP-CH-I/GFRP interaction surface; other site
487214000949	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
487214000950	homooctamer interface [polypeptide binding]; other site
487214000951	active site
487214000952	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
487214000953	catalytic center binding site [active]
487214000954	ATP binding site [chemical binding]; other site
487214000955	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
487214000956	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
487214000957	23S rRNA interface [nucleotide binding]; other site
487214000958	L3 interface [polypeptide binding]; other site
487214000959	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
487214000960	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
487214000961	active site
487214000962	catalytic residues [active]
487214000963	DNA binding site [nucleotide binding]
487214000964	Int/Topo IB signature motif; other site
487214000965	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487214000966	Oxygen-sensitive ribonucleoside-triphosphate reductase [Nucleotide transport and metabolism]; Region: NrdD; COG1328
487214000967	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
487214000968	DNA binding site [nucleotide binding]
487214000969	active site
487214000970	Int/Topo IB signature motif; other site
487214000971	catalytic residues [active]
487214000972	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
487214000973	AAA domain; Region: AAA_14; pfam13173
487214000974	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
487214000975	This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595
487214000976	putative active site [active]
487214000977	putative catalytic site [active]
487214000978	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
487214000979	catalytic residues [active]
487214000980	dimer interface [polypeptide binding]; other site
487214000981	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
487214000982	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
487214000983	substrate binding site [chemical binding]; other site
487214000984	catalytic residues [active]
487214000985	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
487214000986	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
487214000987	active site
487214000988	intersubunit interface [polypeptide binding]; other site
487214000989	catalytic residue [active]
487214000990	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
487214000991	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
487214000992	substrate binding site [chemical binding]; other site
487214000993	ATP binding site [chemical binding]; other site
487214000994	hypothetical protein; Provisional; Region: PRK09273
487214000995	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
487214000996	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
487214000997	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
487214000998	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
487214000999	NADP binding site [chemical binding]; other site
487214001000	homodimer interface [polypeptide binding]; other site
487214001001	active site
487214001002	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
487214001003	active pocket/dimerization site; other site
487214001004	active site
487214001005	phosphorylation site [posttranslational modification]
487214001006	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
487214001007	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
487214001008	active site
487214001009	phosphorylation site [posttranslational modification]
487214001010	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
487214001011	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
487214001012	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
487214001013	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
487214001014	Transcriptional regulators [Transcription]; Region: PurR; COG1609
487214001015	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
487214001016	DNA binding site [nucleotide binding]
487214001017	domain linker motif; other site
487214001018	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
487214001019	putative dimerization interface [polypeptide binding]; other site
487214001020	putative ligand binding site [chemical binding]; other site
487214001021	Protein of unknown function (DUF3278); Region: DUF3278; pfam11683
487214001022	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214001023	non-specific DNA binding site [nucleotide binding]; other site
487214001024	salt bridge; other site
487214001025	sequence-specific DNA binding site [nucleotide binding]; other site
487214001026	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
487214001027	MraW methylase family; Region: Methyltransf_5; pfam01795
487214001028	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
487214001029	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
487214001030	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
487214001031	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
487214001032	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
487214001033	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
487214001034	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
487214001035	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
487214001036	Mg++ binding site [ion binding]; other site
487214001037	putative catalytic motif [active]
487214001038	putative substrate binding site [chemical binding]; other site
487214001039	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214001040	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
487214001041	Walker A motif; other site
487214001042	ATP binding site [chemical binding]; other site
487214001043	Walker B motif; other site
487214001044	arginine finger; other site
487214001045	UvrB/uvrC motif; Region: UVR; pfam02151
487214001046	MoxR-like ATPases [General function prediction only]; Region: COG0714
487214001047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214001048	Walker A motif; other site
487214001049	ATP binding site [chemical binding]; other site
487214001050	Walker B motif; other site
487214001051	arginine finger; other site
487214001052	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
487214001053	group II catalytic intron
487214001054	LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854
487214001055	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
487214001056	hypothetical protein; Provisional; Region: PRK13663
487214001057	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
487214001058	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
487214001059	Ca binding site [ion binding]; other site
487214001060	active site
487214001061	catalytic site [active]
487214001062	Helix-turn-helix domain; Region: HTH_28; pfam13518
487214001063	Winged helix-turn helix; Region: HTH_29; pfam13551
487214001064	DNA polymerase processivity factor; Region: DNA_PPF; pfam02916
487214001065	Transcriptional regulator [Transcription]; Region: LytR; COG1316
487214001066	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
487214001067	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
487214001068	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
487214001069	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
487214001070	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
487214001071	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
487214001072	Bacterial sugar transferase; Region: Bac_transf; pfam02397
487214001073	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
487214001074	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
487214001075	LicD family; Region: LicD; pfam04991
487214001076	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
487214001077	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
487214001078	active site
487214001079	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
487214001080	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
487214001081	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
487214001082	active site
487214001083	homodimer interface [polypeptide binding]; other site
487214001084	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
487214001085	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
487214001086	substrate binding site; other site
487214001087	tetramer interface; other site
487214001088	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
487214001089	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
487214001090	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
487214001091	NAD binding site [chemical binding]; other site
487214001092	substrate binding site [chemical binding]; other site
487214001093	homodimer interface [polypeptide binding]; other site
487214001094	active site
487214001095	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
487214001096	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
487214001097	NADP binding site [chemical binding]; other site
487214001098	active site
487214001099	putative substrate binding site [chemical binding]; other site
487214001100	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
487214001101	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
487214001102	peptide binding site [polypeptide binding]; other site
487214001103	Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905
487214001104	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
487214001105	Transglycosylase; Region: Transgly; pfam00912
487214001106	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
487214001107	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
487214001108	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
487214001109	hypothetical protein; Provisional; Region: PRK13660
487214001110	cell division protein GpsB; Provisional; Region: PRK14127
487214001111	DivIVA domain; Region: DivI1A_domain; TIGR03544
487214001112	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
487214001113	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
487214001114	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
487214001115	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
487214001116	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
487214001117	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
487214001118	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487214001119	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487214001120	active site
487214001121	phosphorylation site [posttranslational modification]
487214001122	intermolecular recognition site; other site
487214001123	dimerization interface [polypeptide binding]; other site
487214001124	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487214001125	DNA binding site [nucleotide binding]
487214001126	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
487214001127	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
487214001128	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
487214001129	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
487214001130	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
487214001131	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
487214001132	diphosphomevalonate decarboxylase; Region: PLN02407
487214001133	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
487214001134	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
487214001135	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
487214001136	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
487214001137	homotetramer interface [polypeptide binding]; other site
487214001138	FMN binding site [chemical binding]; other site
487214001139	homodimer contacts [polypeptide binding]; other site
487214001140	putative active site [active]
487214001141	putative substrate binding site [chemical binding]; other site
487214001142	Predicted membrane protein [Function unknown]; Region: COG4758
487214001143	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
487214001144	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487214001145	Histidine kinase; Region: HisKA_3; pfam07730
487214001146	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214001147	ATP binding site [chemical binding]; other site
487214001148	Mg2+ binding site [ion binding]; other site
487214001149	G-X-G motif; other site
487214001150	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
487214001151	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487214001152	active site
487214001153	phosphorylation site [posttranslational modification]
487214001154	intermolecular recognition site; other site
487214001155	dimerization interface [polypeptide binding]; other site
487214001156	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
487214001157	DNA binding residues [nucleotide binding]
487214001158	dimerization interface [polypeptide binding]; other site
487214001159	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
487214001160	putative transposase OrfB; Reviewed; Region: PHA02517
487214001161	HTH-like domain; Region: HTH_21; pfam13276
487214001162	Integrase core domain; Region: rve; pfam00665
487214001163	Integrase core domain; Region: rve_2; pfam13333
487214001164	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
487214001165	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
487214001166	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
487214001167	active site
487214001168	P-loop; other site
487214001169	phosphorylation site [posttranslational modification]
487214001170	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
487214001171	active site
487214001172	P-loop; other site
487214001173	phosphorylation site [posttranslational modification]
487214001174	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
487214001175	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
487214001176	active site
487214001177	P-loop; other site
487214001178	phosphorylation site [posttranslational modification]
487214001179	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
487214001180	active site
487214001181	phosphorylation site [posttranslational modification]
487214001182	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
487214001183	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
487214001184	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
487214001185	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
487214001186	trigger factor; Provisional; Region: tig; PRK01490
487214001187	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
487214001188	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
487214001189	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
487214001190	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
487214001191	DNA binding site [nucleotide binding]
487214001192	AAA domain; Region: AAA_30; pfam13604
487214001193	Family description; Region: UvrD_C_2; pfam13538
487214001194	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
487214001195	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
487214001196	Catalytic site [active]
487214001197	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
487214001198	ribonuclease HIII; Provisional; Region: PRK00996
487214001199	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
487214001200	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
487214001201	RNA/DNA hybrid binding site [nucleotide binding]; other site
487214001202	active site
487214001203	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
487214001204	Colicin V production protein; Region: Colicin_V; pfam02674
487214001205	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193
487214001206	MutS domain III; Region: MutS_III; pfam05192
487214001207	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
487214001208	Walker A/P-loop; other site
487214001209	ATP binding site [chemical binding]; other site
487214001210	Q-loop/lid; other site
487214001211	ABC transporter signature motif; other site
487214001212	Walker B; other site
487214001213	D-loop; other site
487214001214	H-loop/switch region; other site
487214001215	Smr domain; Region: Smr; pfam01713
487214001216	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
487214001217	amino acid carrier protein; Region: agcS; TIGR00835
487214001218	Uncharacterized conserved protein [Function unknown]; Region: COG2128
487214001219	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
487214001220	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
487214001221	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
487214001222	gating phenylalanine in ion channel; other site
487214001223	seryl-tRNA synthetase; Provisional; Region: PRK05431
487214001224	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
487214001225	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
487214001226	dimer interface [polypeptide binding]; other site
487214001227	active site
487214001228	motif 1; other site
487214001229	motif 2; other site
487214001230	motif 3; other site
487214001231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687
487214001232	aspartate kinase; Reviewed; Region: PRK09034
487214001233	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
487214001234	putative catalytic residues [active]
487214001235	putative nucleotide binding site [chemical binding]; other site
487214001236	putative aspartate binding site [chemical binding]; other site
487214001237	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
487214001238	allosteric regulatory residue; other site
487214001239	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
487214001240	enoyl-CoA hydratase; Provisional; Region: PRK07260
487214001241	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
487214001242	substrate binding site [chemical binding]; other site
487214001243	oxyanion hole (OAH) forming residues; other site
487214001244	trimer interface [polypeptide binding]; other site
487214001245	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
487214001246	MarR family; Region: MarR_2; pfam12802
487214001247	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
487214001248	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
487214001249	dimer interface [polypeptide binding]; other site
487214001250	active site
487214001251	CoA binding pocket [chemical binding]; other site
487214001252	acyl carrier protein; Provisional; Region: acpP; PRK00982
487214001253	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
487214001254	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
487214001255	FMN binding site [chemical binding]; other site
487214001256	substrate binding site [chemical binding]; other site
487214001257	putative catalytic residue [active]
487214001258	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
487214001259	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
487214001260	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
487214001261	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
487214001262	NAD(P) binding site [chemical binding]; other site
487214001263	homotetramer interface [polypeptide binding]; other site
487214001264	homodimer interface [polypeptide binding]; other site
487214001265	active site
487214001266	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
487214001267	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
487214001268	dimer interface [polypeptide binding]; other site
487214001269	active site
487214001270	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
487214001271	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
487214001272	carboxyltransferase (CT) interaction site; other site
487214001273	biotinylation site [posttranslational modification]; other site
487214001274	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
487214001275	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
487214001276	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
487214001277	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
487214001278	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
487214001279	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
487214001280	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
487214001281	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
487214001282	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
487214001283	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
487214001284	putative RNA binding site [nucleotide binding]; other site
487214001285	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
487214001286	elongation factor P; Validated; Region: PRK00529
487214001287	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
487214001288	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
487214001289	RNA binding site [nucleotide binding]; other site
487214001290	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
487214001291	RNA binding site [nucleotide binding]; other site
487214001292	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
487214001293	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
487214001294	GatB domain; Region: GatB_Yqey; pfam02637
487214001295	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
487214001296	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
487214001297	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
487214001298	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
487214001299	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
487214001300	G1 box; other site
487214001301	putative GEF interaction site [polypeptide binding]; other site
487214001302	GTP/Mg2+ binding site [chemical binding]; other site
487214001303	Switch I region; other site
487214001304	G2 box; other site
487214001305	G3 box; other site
487214001306	Switch II region; other site
487214001307	G4 box; other site
487214001308	G5 box; other site
487214001309	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
487214001310	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
487214001311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
487214001312	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
487214001313	DAK2 domain; Region: Dak2; pfam02734
487214001314	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282
487214001315	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
487214001316	PYR/PP interface [polypeptide binding]; other site
487214001317	dimer interface [polypeptide binding]; other site
487214001318	TPP binding site [chemical binding]; other site
487214001319	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
487214001320	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
487214001321	TPP-binding site [chemical binding]; other site
487214001322	dimer interface [polypeptide binding]; other site
487214001323	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
487214001324	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
487214001325	putative valine binding site [chemical binding]; other site
487214001326	dimer interface [polypeptide binding]; other site
487214001327	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
487214001328	ketol-acid reductoisomerase; Provisional; Region: PRK05479
487214001329	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
487214001330	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
487214001331	threonine dehydratase; Validated; Region: PRK08639
487214001332	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
487214001333	tetramer interface [polypeptide binding]; other site
487214001334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487214001335	catalytic residue [active]
487214001336	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
487214001337	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
487214001338	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214001339	Walker A/P-loop; other site
487214001340	ATP binding site [chemical binding]; other site
487214001341	Q-loop/lid; other site
487214001342	ABC transporter signature motif; other site
487214001343	Walker B; other site
487214001344	D-loop; other site
487214001345	H-loop/switch region; other site
487214001346	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
487214001347	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
487214001348	substrate binding pocket [chemical binding]; other site
487214001349	membrane-bound complex binding site; other site
487214001350	hinge residues; other site
487214001351	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214001352	dimer interface [polypeptide binding]; other site
487214001353	conserved gate region; other site
487214001354	putative PBP binding loops; other site
487214001355	ABC-ATPase subunit interface; other site
487214001356	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
487214001357	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
487214001358	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
487214001359	active site
487214001360	DNA polymerase IV; Validated; Region: PRK02406
487214001361	DNA binding site [nucleotide binding]
487214001362	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
487214001363	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
487214001364	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
487214001365	Transposase; Region: DDE_Tnp_ISL3; pfam01610
487214001366	Mga helix-turn-helix domain; Region: Mga; pfam05043
487214001367	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
487214001368	Cna protein B-type domain; Region: Cna_B; pfam05738
487214001369	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
487214001370	metal ion-dependent adhesion site (MIDAS); other site
487214001371	Cna protein B-type domain; Region: Cna_B; pfam05738
487214001372	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
487214001373	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
487214001374	domain interaction interfaces [polypeptide binding]; other site
487214001375	Cna protein B-type domain; Region: Cna_B; pfam05738
487214001376	Cna protein B-type domain; Region: Cna_B; pfam05738
487214001377	Cna protein B-type domain; Region: Cna_B; pfam05738
487214001378	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
487214001379	active site
487214001380	catalytic site [active]
487214001381	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
487214001382	active site
487214001383	catalytic site [active]
487214001384	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
487214001385	active site
487214001386	catalytic site [active]
487214001387	Transcriptional regulators [Transcription]; Region: MarR; COG1846
487214001388	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
487214001389	non-specific DNA interactions [nucleotide binding]; other site
487214001390	DNA binding site [nucleotide binding]
487214001391	sequence specific DNA binding site [nucleotide binding]; other site
487214001392	putative cAMP binding site [chemical binding]; other site
487214001393	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
487214001394	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
487214001395	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
487214001396	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
487214001397	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
487214001398	methionine cluster; other site
487214001399	active site
487214001400	phosphorylation site [posttranslational modification]
487214001401	metal binding site [ion binding]; metal-binding site
487214001402	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
487214001403	beta-galactosidase; Region: BGL; TIGR03356
487214001404	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
487214001405	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
487214001406	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
487214001407	active site
487214001408	P-loop; other site
487214001409	phosphorylation site [posttranslational modification]
487214001410	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
487214001411	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
487214001412	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
487214001413	TrkA-N domain; Region: TrkA_N; pfam02254
487214001414	TrkA-C domain; Region: TrkA_C; pfam02080
487214001415	TrkA-N domain; Region: TrkA_N; pfam02254
487214001416	TrkA-C domain; Region: TrkA_C; pfam02080
487214001417	Uncharacterized conserved protein [Function unknown]; Region: COG1912
487214001418	hypothetical protein; Provisional; Region: PRK13661
487214001419	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
487214001420	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
487214001421	Walker A/P-loop; other site
487214001422	ATP binding site [chemical binding]; other site
487214001423	Q-loop/lid; other site
487214001424	ABC transporter signature motif; other site
487214001425	Walker B; other site
487214001426	D-loop; other site
487214001427	H-loop/switch region; other site
487214001428	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
487214001429	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
487214001430	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
487214001431	Walker A/P-loop; other site
487214001432	ATP binding site [chemical binding]; other site
487214001433	Q-loop/lid; other site
487214001434	ABC transporter signature motif; other site
487214001435	Walker B; other site
487214001436	D-loop; other site
487214001437	H-loop/switch region; other site
487214001438	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
487214001439	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
487214001440	Predicted membrane protein [Function unknown]; Region: COG3601
487214001441	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
487214001442	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
487214001443	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
487214001444	active site
487214001445	ParB-like nuclease domain; Region: ParBc; cl02129
487214001446	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
487214001447	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
487214001448	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
487214001449	CTP synthetase; Validated; Region: pyrG; PRK05380
487214001450	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
487214001451	Catalytic site [active]
487214001452	active site
487214001453	UTP binding site [chemical binding]; other site
487214001454	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
487214001455	active site
487214001456	putative oxyanion hole; other site
487214001457	catalytic triad [active]
487214001458	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
487214001459	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
487214001460	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
487214001461	PhoU domain; Region: PhoU; pfam01895
487214001462	PhoU domain; Region: PhoU; pfam01895
487214001463	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
487214001464	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
487214001465	Glycosyl hydrolase family 85; Region: Glyco_hydro_85; pfam03644
487214001466	active site
487214001467	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
487214001468	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
487214001469	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
487214001470	G5 domain; Region: G5; pfam07501
487214001471	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
487214001472	Phosphoglycerate kinase; Region: PGK; pfam00162
487214001473	substrate binding site [chemical binding]; other site
487214001474	hinge regions; other site
487214001475	ADP binding site [chemical binding]; other site
487214001476	catalytic site [active]
487214001477	Predicted membrane protein [Function unknown]; Region: COG4129
487214001478	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
487214001479	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
487214001480	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
487214001481	DNA binding residues [nucleotide binding]
487214001482	putative dimer interface [polypeptide binding]; other site
487214001483	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
487214001484	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
487214001485	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
487214001486	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
487214001487	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
487214001488	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
487214001489	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
487214001490	VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196
487214001491	Int/Topo IB signature motif; other site
487214001492	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
487214001493	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
487214001494	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
487214001495	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
487214001496	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
487214001497	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
487214001498	HsdM N-terminal domain; Region: HsdM_N; pfam12161
487214001499	Methyltransferase domain; Region: Methyltransf_26; pfam13659
487214001500	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
487214001501	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
487214001502	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487214001503	ATP binding site [chemical binding]; other site
487214001504	putative Mg++ binding site [ion binding]; other site
487214001505	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
487214001506	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
487214001507	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
487214001508	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
487214001509	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
487214001510	dimer interface [polypeptide binding]; other site
487214001511	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
487214001512	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
487214001513	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
487214001514	nucleotide binding site [chemical binding]; other site
487214001515	NEF interaction site [polypeptide binding]; other site
487214001516	SBD interface [polypeptide binding]; other site
487214001517	chaperone protein DnaJ; Provisional; Region: PRK14276
487214001518	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
487214001519	HSP70 interaction site [polypeptide binding]; other site
487214001520	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
487214001521	substrate binding site [polypeptide binding]; other site
487214001522	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
487214001523	Zn binding sites [ion binding]; other site
487214001524	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
487214001525	substrate binding site [polypeptide binding]; other site
487214001526	dimer interface [polypeptide binding]; other site
487214001527	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
487214001528	HIT family signature motif; other site
487214001529	catalytic residue [active]
487214001530	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
487214001531	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
487214001532	Walker A/P-loop; other site
487214001533	ATP binding site [chemical binding]; other site
487214001534	Q-loop/lid; other site
487214001535	ABC transporter signature motif; other site
487214001536	Walker B; other site
487214001537	D-loop; other site
487214001538	H-loop/switch region; other site
487214001539	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
487214001540	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
487214001541	LytTr DNA-binding domain; Region: LytTR; pfam04397
487214001542	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
487214001543	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487214001544	active site
487214001545	phosphorylation site [posttranslational modification]
487214001546	intermolecular recognition site; other site
487214001547	dimerization interface [polypeptide binding]; other site
487214001548	LytTr DNA-binding domain; Region: LytTR; pfam04397
487214001549	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
487214001550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214001551	ATP binding site [chemical binding]; other site
487214001552	Mg2+ binding site [ion binding]; other site
487214001553	G-X-G motif; other site
487214001554	COMC family; Region: ComC; pfam03047
487214001555	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
487214001556	HlyD family secretion protein; Region: HlyD_3; pfam13437
487214001557	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
487214001558	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
487214001559	putative active site [active]
487214001560	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
487214001561	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214001562	Walker A/P-loop; other site
487214001563	ATP binding site [chemical binding]; other site
487214001564	Q-loop/lid; other site
487214001565	ABC transporter signature motif; other site
487214001566	Walker B; other site
487214001567	D-loop; other site
487214001568	H-loop/switch region; other site
487214001569	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
487214001570	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
487214001571	CAAX protease self-immunity; Region: Abi; pfam02517
487214001572	CAAX protease self-immunity; Region: Abi; pfam02517
487214001573	Phosphotransferase enzyme family; Region: APH; pfam01636
487214001574	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
487214001575	substrate binding site [chemical binding]; other site
487214001576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214001577	S-adenosylmethionine binding site [chemical binding]; other site
487214001578	ribosome maturation protein RimP; Reviewed; Region: PRK00092
487214001579	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
487214001580	putative oligomer interface [polypeptide binding]; other site
487214001581	putative RNA binding site [nucleotide binding]; other site
487214001582	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
487214001583	NusA N-terminal domain; Region: NusA_N; pfam08529
487214001584	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
487214001585	RNA binding site [nucleotide binding]; other site
487214001586	homodimer interface [polypeptide binding]; other site
487214001587	NusA-like KH domain; Region: KH_5; pfam13184
487214001588	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
487214001589	G-X-X-G motif; other site
487214001590	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
487214001591	putative RNA binding cleft [nucleotide binding]; other site
487214001592	hypothetical protein; Provisional; Region: PRK07283
487214001593	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
487214001594	translation initiation factor IF-2; Region: IF-2; TIGR00487
487214001595	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
487214001596	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
487214001597	G1 box; other site
487214001598	putative GEF interaction site [polypeptide binding]; other site
487214001599	GTP/Mg2+ binding site [chemical binding]; other site
487214001600	Switch I region; other site
487214001601	G2 box; other site
487214001602	G3 box; other site
487214001603	Switch II region; other site
487214001604	G4 box; other site
487214001605	G5 box; other site
487214001606	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
487214001607	Translation-initiation factor 2; Region: IF-2; pfam11987
487214001608	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
487214001609	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
487214001610	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
487214001611	Uncharacterized conserved protein [Function unknown]; Region: COG2461
487214001612	Family of unknown function (DUF438); Region: DUF438; pfam04282
487214001613	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
487214001614	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
487214001615	putative active site [active]
487214001616	heme pocket [chemical binding]; other site
487214001617	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
487214001618	hypothetical protein; Provisional; Region: PRK07758
487214001619	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
487214001620	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
487214001621	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
487214001622	Coenzyme A binding pocket [chemical binding]; other site
487214001623	AAA domain; Region: AAA_18; pfam13238
487214001624	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
487214001625	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
487214001626	active site
487214001627	HIGH motif; other site
487214001628	nucleotide binding site [chemical binding]; other site
487214001629	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
487214001630	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
487214001631	active site
487214001632	KMSKS motif; other site
487214001633	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
487214001634	tRNA binding surface [nucleotide binding]; other site
487214001635	anticodon binding site; other site
487214001636	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
487214001637	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
487214001638	cofactor binding site; other site
487214001639	AAA domain; Region: AAA_21; pfam13304
487214001640	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214001641	ABC transporter signature motif; other site
487214001642	Walker B; other site
487214001643	D-loop; other site
487214001644	H-loop/switch region; other site
487214001645	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
487214001646	Fic/DOC family; Region: Fic; pfam02661
487214001647	transcriptional antiterminator BglG; Provisional; Region: PRK09772
487214001648	CAT RNA binding domain; Region: CAT_RBD; smart01061
487214001649	PRD domain; Region: PRD; pfam00874
487214001650	PRD domain; Region: PRD; pfam00874
487214001651	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
487214001652	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
487214001653	active site turn [active]
487214001654	phosphorylation site [posttranslational modification]
487214001655	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
487214001656	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
487214001657	HPr interaction site; other site
487214001658	glycerol kinase (GK) interaction site [polypeptide binding]; other site
487214001659	active site
487214001660	phosphorylation site [posttranslational modification]
487214001661	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
487214001662	beta-galactosidase; Region: BGL; TIGR03356
487214001663	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
487214001664	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
487214001665	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
487214001666	dimer interface [polypeptide binding]; other site
487214001667	motif 1; other site
487214001668	active site
487214001669	motif 2; other site
487214001670	motif 3; other site
487214001671	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
487214001672	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487214001673	Coenzyme A binding pocket [chemical binding]; other site
487214001674	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
487214001675	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
487214001676	putative tRNA-binding site [nucleotide binding]; other site
487214001677	B3/4 domain; Region: B3_4; pfam03483
487214001678	tRNA synthetase B5 domain; Region: B5; smart00874
487214001679	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
487214001680	dimer interface [polypeptide binding]; other site
487214001681	motif 1; other site
487214001682	motif 3; other site
487214001683	motif 2; other site
487214001684	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
487214001685	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
487214001686	putative catalytic site [active]
487214001687	putative metal binding site [ion binding]; other site
487214001688	putative phosphate binding site [ion binding]; other site
487214001689	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
487214001690	Helix-turn-helix domain; Region: HTH_38; pfam13936
487214001691	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214001692	non-specific DNA binding site [nucleotide binding]; other site
487214001693	salt bridge; other site
487214001694	sequence-specific DNA binding site [nucleotide binding]; other site
487214001695	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
487214001696	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
487214001697	THF binding site; other site
487214001698	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
487214001699	substrate binding site [chemical binding]; other site
487214001700	THF binding site; other site
487214001701	zinc-binding site [ion binding]; other site
487214001702	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
487214001703	FAD binding site [chemical binding]; other site
487214001704	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
487214001705	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
487214001706	RNase E interface [polypeptide binding]; other site
487214001707	trimer interface [polypeptide binding]; other site
487214001708	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
487214001709	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
487214001710	RNase E interface [polypeptide binding]; other site
487214001711	trimer interface [polypeptide binding]; other site
487214001712	active site
487214001713	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
487214001714	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
487214001715	RNA binding site [nucleotide binding]; other site
487214001716	domain interface; other site
487214001717	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
487214001718	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
487214001719	trimer interface [polypeptide binding]; other site
487214001720	active site
487214001721	substrate binding site [chemical binding]; other site
487214001722	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487214001723	Coenzyme A binding pocket [chemical binding]; other site
487214001724	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
487214001725	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487214001726	Coenzyme A binding pocket [chemical binding]; other site
487214001727	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
487214001728	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
487214001729	active site
487214001730	HIGH motif; other site
487214001731	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
487214001732	KMSKS motif; other site
487214001733	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
487214001734	tRNA binding surface [nucleotide binding]; other site
487214001735	anticodon binding site; other site
487214001736	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
487214001737	active site
487214001738	metal binding site [ion binding]; metal-binding site
487214001739	dimerization interface [polypeptide binding]; other site
487214001740	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
487214001741	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
487214001742	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
487214001743	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
487214001744	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
487214001745	FtsX-like permease family; Region: FtsX; pfam02687
487214001746	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
487214001747	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
487214001748	Walker A/P-loop; other site
487214001749	ATP binding site [chemical binding]; other site
487214001750	Q-loop/lid; other site
487214001751	ABC transporter signature motif; other site
487214001752	Walker B; other site
487214001753	D-loop; other site
487214001754	H-loop/switch region; other site
487214001755	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
487214001756	FtsX-like permease family; Region: FtsX; pfam02687
487214001757	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487214001758	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487214001759	active site
487214001760	phosphorylation site [posttranslational modification]
487214001761	intermolecular recognition site; other site
487214001762	dimerization interface [polypeptide binding]; other site
487214001763	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487214001764	DNA binding site [nucleotide binding]
487214001765	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487214001766	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
487214001767	dimerization interface [polypeptide binding]; other site
487214001768	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487214001769	dimer interface [polypeptide binding]; other site
487214001770	phosphorylation site [posttranslational modification]
487214001771	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214001772	ATP binding site [chemical binding]; other site
487214001773	Mg2+ binding site [ion binding]; other site
487214001774	G-X-G motif; other site
487214001775	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
487214001776	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
487214001777	intersubunit interface [polypeptide binding]; other site
487214001778	active site
487214001779	zinc binding site [ion binding]; other site
487214001780	Na+ binding site [ion binding]; other site
487214001781	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
487214001782	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
487214001783	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
487214001784	FAD binding pocket [chemical binding]; other site
487214001785	FAD binding motif [chemical binding]; other site
487214001786	phosphate binding motif [ion binding]; other site
487214001787	beta-alpha-beta structure motif; other site
487214001788	NAD binding pocket [chemical binding]; other site
487214001789	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214001790	dimer interface [polypeptide binding]; other site
487214001791	conserved gate region; other site
487214001792	putative PBP binding loops; other site
487214001793	ABC-ATPase subunit interface; other site
487214001794	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214001795	dimer interface [polypeptide binding]; other site
487214001796	conserved gate region; other site
487214001797	putative PBP binding loops; other site
487214001798	ABC-ATPase subunit interface; other site
487214001799	bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917
487214001800	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
487214001801	substrate binding pocket [chemical binding]; other site
487214001802	membrane-bound complex binding site; other site
487214001803	hinge residues; other site
487214001804	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
487214001805	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
487214001806	Walker A/P-loop; other site
487214001807	ATP binding site [chemical binding]; other site
487214001808	Q-loop/lid; other site
487214001809	ABC transporter signature motif; other site
487214001810	Walker B; other site
487214001811	D-loop; other site
487214001812	H-loop/switch region; other site
487214001813	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
487214001814	DHH family; Region: DHH; pfam01368
487214001815	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
487214001816	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
487214001817	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
487214001818	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
487214001819	Predicted esterase [General function prediction only]; Region: COG0627
487214001820	S-formylglutathione hydrolase; Region: PLN02442
487214001821	FemAB family; Region: FemAB; pfam02388
487214001822	FemAB family; Region: FemAB; pfam02388
487214001823	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
487214001824	active site
487214001825	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
487214001826	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
487214001827	GIY-YIG motif/motif A; other site
487214001828	active site
487214001829	catalytic site [active]
487214001830	putative DNA binding site [nucleotide binding]; other site
487214001831	metal binding site [ion binding]; metal-binding site
487214001832	UvrB/uvrC motif; Region: UVR; pfam02151
487214001833	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
487214001834	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
487214001835	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
487214001836	active site
487214001837	metal binding site [ion binding]; metal-binding site
487214001838	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
487214001839	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
487214001840	substrate binding pocket [chemical binding]; other site
487214001841	membrane-bound complex binding site; other site
487214001842	hinge residues; other site
487214001843	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
487214001844	dimer interface [polypeptide binding]; other site
487214001845	FMN binding site [chemical binding]; other site
487214001846	dipeptidase PepV; Reviewed; Region: PRK07318
487214001847	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
487214001848	active site
487214001849	metal binding site [ion binding]; metal-binding site
487214001850	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
487214001851	putative uracil binding site [chemical binding]; other site
487214001852	putative active site [active]
487214001853	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
487214001854	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
487214001855	active site residue [active]
487214001856	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
487214001857	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
487214001858	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
487214001859	putative oligomer interface [polypeptide binding]; other site
487214001860	putative active site [active]
487214001861	metal binding site [ion binding]; metal-binding site
487214001862	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
487214001863	nucleotide binding site/active site [active]
487214001864	HIT family signature motif; other site
487214001865	catalytic residue [active]
487214001866	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
487214001867	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
487214001868	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
487214001869	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
487214001870	23S rRNA interface [nucleotide binding]; other site
487214001871	L7/L12 interface [polypeptide binding]; other site
487214001872	putative thiostrepton binding site; other site
487214001873	L25 interface [polypeptide binding]; other site
487214001874	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
487214001875	mRNA/rRNA interface [nucleotide binding]; other site
487214001876	group II catalytic intron
487214001877	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
487214001878	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214001879	Walker A/P-loop; other site
487214001880	ATP binding site [chemical binding]; other site
487214001881	Q-loop/lid; other site
487214001882	ABC transporter signature motif; other site
487214001883	Walker B; other site
487214001884	D-loop; other site
487214001885	H-loop/switch region; other site
487214001886	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
487214001887	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
487214001888	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
487214001889	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
487214001890	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
487214001891	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
487214001892	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
487214001893	putative active site [active]
487214001894	catalytic triad [active]
487214001895	PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819
487214001896	PA/protease or protease-like domain interface [polypeptide binding]; other site
487214001897	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
487214001898	catalytic residues [active]
487214001899	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
487214001900	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
487214001901	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
487214001902	DDE superfamily endonuclease; Region: DDE_3; pfam13358
487214001903	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
487214001904	active site
487214001905	phosphorylation site [posttranslational modification]
487214001906	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
487214001907	active site
487214001908	P-loop; other site
487214001909	phosphorylation site [posttranslational modification]
487214001910	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
487214001911	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
487214001912	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
487214001913	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
487214001914	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
487214001915	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
487214001916	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
487214001917	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
487214001918	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
487214001919	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
487214001920	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
487214001921	G5 domain; Region: G5; pfam07501
487214001922	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
487214001923	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
487214001924	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
487214001925	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
487214001926	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
487214001927	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
487214001928	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
487214001929	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
487214001930	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
487214001931	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
487214001932	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
487214001933	catalytic residues [active]
487214001934	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
487214001935	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
487214001936	SelR domain; Region: SelR; pfam01641
487214001937	Response regulator receiver domain; Region: Response_reg; pfam00072
487214001938	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487214001939	active site
487214001940	phosphorylation site [posttranslational modification]
487214001941	intermolecular recognition site; other site
487214001942	dimerization interface [polypeptide binding]; other site
487214001943	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
487214001944	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487214001945	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
487214001946	Cache domain; Region: Cache_1; pfam02743
487214001947	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
487214001948	dimerization interface [polypeptide binding]; other site
487214001949	Histidine kinase; Region: His_kinase; pfam06580
487214001950	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214001951	ATP binding site [chemical binding]; other site
487214001952	Mg2+ binding site [ion binding]; other site
487214001953	G-X-G motif; other site
487214001954	hypothetical protein; Provisional; Region: PRK13690
487214001955	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
487214001956	Surface protein; Region: DUF3664; pfam12406
487214001957	G5 domain; Region: G5; pfam07501
487214001958	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
487214001959	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
487214001960	aminodeoxychorismate synthase; Provisional; Region: PRK07508
487214001961	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
487214001962	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
487214001963	substrate-cofactor binding pocket; other site
487214001964	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
487214001965	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487214001966	catalytic residue [active]
487214001967	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
487214001968	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
487214001969	Excalibur calcium-binding domain; Region: Excalibur; smart00894
487214001970	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
487214001971	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
487214001972	nucleotide binding site [chemical binding]; other site
487214001973	thymidylate synthase; Reviewed; Region: thyA; PRK01827
487214001974	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
487214001975	dimerization interface [polypeptide binding]; other site
487214001976	active site
487214001977	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
487214001978	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
487214001979	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
487214001980	GTPases [General function prediction only]; Region: HflX; COG2262
487214001981	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
487214001982	HflX GTPase family; Region: HflX; cd01878
487214001983	G1 box; other site
487214001984	GTP/Mg2+ binding site [chemical binding]; other site
487214001985	Switch I region; other site
487214001986	G2 box; other site
487214001987	G3 box; other site
487214001988	Switch II region; other site
487214001989	G4 box; other site
487214001990	G5 box; other site
487214001991	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
487214001992	ribonuclease Z; Region: RNase_Z; TIGR02651
487214001993	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
487214001994	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
487214001995	NAD(P) binding site [chemical binding]; other site
487214001996	active site
487214001997	Transcriptional regulator [Transcription]; Region: LysR; COG0583
487214001998	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
487214001999	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
487214002000	dimerization interface [polypeptide binding]; other site
487214002001	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
487214002002	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
487214002003	active site residue [active]
487214002004	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
487214002005	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
487214002006	RNA binding surface [nucleotide binding]; other site
487214002007	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
487214002008	active site
487214002009	uracil binding [chemical binding]; other site
487214002010	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
487214002011	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
487214002012	G1 box; other site
487214002013	putative GEF interaction site [polypeptide binding]; other site
487214002014	GTP/Mg2+ binding site [chemical binding]; other site
487214002015	Switch I region; other site
487214002016	G2 box; other site
487214002017	G3 box; other site
487214002018	Switch II region; other site
487214002019	G4 box; other site
487214002020	G5 box; other site
487214002021	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
487214002022	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
487214002023	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
487214002024	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683
487214002025	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214002026	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
487214002027	Walker A/P-loop; other site
487214002028	ATP binding site [chemical binding]; other site
487214002029	Q-loop/lid; other site
487214002030	ABC transporter signature motif; other site
487214002031	Walker B; other site
487214002032	D-loop; other site
487214002033	H-loop/switch region; other site
487214002034	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
487214002035	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
487214002036	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
487214002037	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
487214002038	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
487214002039	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
487214002040	homodimer interface [polypeptide binding]; other site
487214002041	active site
487214002042	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
487214002043	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
487214002044	Cell division protein FtsQ; Region: FtsQ; pfam03799
487214002045	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
487214002046	active site
487214002047	dimer interface [polypeptide binding]; other site
487214002048	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487214002049	active site
487214002050	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
487214002051	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214002052	Walker A/P-loop; other site
487214002053	ATP binding site [chemical binding]; other site
487214002054	Q-loop/lid; other site
487214002055	ABC transporter signature motif; other site
487214002056	Walker B; other site
487214002057	D-loop; other site
487214002058	H-loop/switch region; other site
487214002059	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
487214002060	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
487214002061	substrate binding pocket [chemical binding]; other site
487214002062	membrane-bound complex binding site; other site
487214002063	hinge residues; other site
487214002064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214002065	dimer interface [polypeptide binding]; other site
487214002066	conserved gate region; other site
487214002067	putative PBP binding loops; other site
487214002068	ABC-ATPase subunit interface; other site
487214002069	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
487214002070	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
487214002071	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
487214002072	dimer interface [polypeptide binding]; other site
487214002073	putative anticodon binding site; other site
487214002074	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
487214002075	motif 1; other site
487214002076	active site
487214002077	motif 2; other site
487214002078	motif 3; other site
487214002079	Putative transcription activator [Transcription]; Region: TenA; COG0819
487214002080	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
487214002081	substrate binding site [chemical binding]; other site
487214002082	multimerization interface [polypeptide binding]; other site
487214002083	ATP binding site [chemical binding]; other site
487214002084	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
487214002085	thiamine phosphate binding site [chemical binding]; other site
487214002086	active site
487214002087	pyrophosphate binding site [ion binding]; other site
487214002088	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
487214002089	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
487214002090	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
487214002091	Walker A/P-loop; other site
487214002092	ATP binding site [chemical binding]; other site
487214002093	Q-loop/lid; other site
487214002094	ABC transporter signature motif; other site
487214002095	Walker B; other site
487214002096	D-loop; other site
487214002097	H-loop/switch region; other site
487214002098	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214002099	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
487214002100	Walker A/P-loop; other site
487214002101	ATP binding site [chemical binding]; other site
487214002102	Q-loop/lid; other site
487214002103	ABC transporter signature motif; other site
487214002104	Walker B; other site
487214002105	D-loop; other site
487214002106	H-loop/switch region; other site
487214002107	Putative transcription activator [Transcription]; Region: TenA; COG0819
487214002108	Predicted membrane protein [Function unknown]; Region: COG4732
487214002109	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
487214002110	substrate binding site [chemical binding]; other site
487214002111	multimerization interface [polypeptide binding]; other site
487214002112	ATP binding site [chemical binding]; other site
487214002113	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
487214002114	thiamine phosphate binding site [chemical binding]; other site
487214002115	active site
487214002116	pyrophosphate binding site [ion binding]; other site
487214002117	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
487214002118	dimer interface [polypeptide binding]; other site
487214002119	substrate binding site [chemical binding]; other site
487214002120	ATP binding site [chemical binding]; other site
487214002121	Predicted transcriptional regulator [Transcription]; Region: COG3682
487214002122	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
487214002123	Plastocyanin domain containing protein [General function prediction only]; Region: COG4633
487214002124	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
487214002125	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
487214002126	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
487214002127	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
487214002128	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
487214002129	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
487214002130	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
487214002131	PYR/PP interface [polypeptide binding]; other site
487214002132	dimer interface [polypeptide binding]; other site
487214002133	tetramer interface [polypeptide binding]; other site
487214002134	TPP binding site [chemical binding]; other site
487214002135	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
487214002136	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
487214002137	TPP-binding site [chemical binding]; other site
487214002138	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487214002139	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
487214002140	active site
487214002141	Winged helix-turn helix; Region: HTH_33; pfam13592
487214002142	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
487214002143	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
487214002144	putative active site cavity [active]
487214002145	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
487214002146	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214002147	dimer interface [polypeptide binding]; other site
487214002148	conserved gate region; other site
487214002149	ABC-ATPase subunit interface; other site
487214002150	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
487214002151	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214002152	dimer interface [polypeptide binding]; other site
487214002153	conserved gate region; other site
487214002154	putative PBP binding loops; other site
487214002155	ABC-ATPase subunit interface; other site
487214002156	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
487214002157	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
487214002158	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
487214002159	nucleotide binding site/active site [active]
487214002160	HIT family signature motif; other site
487214002161	catalytic residue [active]
487214002162	Domain of unknown function (DUF386); Region: DUF386; cl01047
487214002163	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
487214002164	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
487214002165	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
487214002166	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
487214002167	putative substrate binding site 1 [chemical binding]; other site
487214002168	Na binding site 1 [ion binding]; other site
487214002169	Na2 binding site [ion binding]; other site
487214002170	Protein of unknown function (DUF1697); Region: DUF1697; cl01557
487214002171	HI0933-like protein; Region: HI0933_like; pfam03486
487214002172	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
487214002173	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
487214002174	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487214002175	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487214002176	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
487214002177	catalytic motif [active]
487214002178	Zn binding site [ion binding]; other site
487214002179	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487214002180	active site
487214002181	Clp protease; Region: CLP_protease; pfam00574
487214002182	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
487214002183	oligomer interface [polypeptide binding]; other site
487214002184	active site residues [active]
487214002185	hypothetical protein; Provisional; Region: PRK02302
487214002186	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
487214002187	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
487214002188	putative ligand binding site [chemical binding]; other site
487214002189	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
487214002190	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
487214002191	TM-ABC transporter signature motif; other site
487214002192	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
487214002193	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
487214002194	TM-ABC transporter signature motif; other site
487214002195	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
487214002196	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
487214002197	Walker A/P-loop; other site
487214002198	ATP binding site [chemical binding]; other site
487214002199	Q-loop/lid; other site
487214002200	ABC transporter signature motif; other site
487214002201	Walker B; other site
487214002202	D-loop; other site
487214002203	H-loop/switch region; other site
487214002204	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
487214002205	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
487214002206	Walker A/P-loop; other site
487214002207	ATP binding site [chemical binding]; other site
487214002208	Q-loop/lid; other site
487214002209	ABC transporter signature motif; other site
487214002210	Walker B; other site
487214002211	D-loop; other site
487214002212	H-loop/switch region; other site
487214002213	FOG: CBS domain [General function prediction only]; Region: COG0517
487214002214	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
487214002215	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
487214002216	peptide chain release factor 2; Region: prfB; TIGR00020
487214002217	PCRF domain; Region: PCRF; pfam03462
487214002218	RF-1 domain; Region: RF-1; pfam00472
487214002219	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
487214002220	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214002221	Walker A/P-loop; other site
487214002222	ATP binding site [chemical binding]; other site
487214002223	Q-loop/lid; other site
487214002224	ABC transporter signature motif; other site
487214002225	Walker B; other site
487214002226	D-loop; other site
487214002227	H-loop/switch region; other site
487214002228	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
487214002229	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
487214002230	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
487214002231	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
487214002232	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
487214002233	active site turn [active]
487214002234	phosphorylation site [posttranslational modification]
487214002235	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
487214002236	HPr interaction site; other site
487214002237	glycerol kinase (GK) interaction site [polypeptide binding]; other site
487214002238	active site
487214002239	phosphorylation site [posttranslational modification]
487214002240	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
487214002241	putative catalytic site [active]
487214002242	putative metal binding site [ion binding]; other site
487214002243	putative phosphate binding site [ion binding]; other site
487214002244	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
487214002245	DEAD-like helicases superfamily; Region: DEXDc; smart00487
487214002246	ATP binding site [chemical binding]; other site
487214002247	Mg++ binding site [ion binding]; other site
487214002248	motif III; other site
487214002249	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487214002250	nucleotide binding region [chemical binding]; other site
487214002251	ATP-binding site [chemical binding]; other site
487214002252	S-adenosylmethionine synthetase; Validated; Region: PRK05250
487214002253	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
487214002254	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
487214002255	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
487214002256	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
487214002257	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
487214002258	active site
487214002259	FMN binding site [chemical binding]; other site
487214002260	substrate binding site [chemical binding]; other site
487214002261	catalytic residues [active]
487214002262	homodimer interface [polypeptide binding]; other site
487214002263	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
487214002264	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
487214002265	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
487214002266	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
487214002267	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
487214002268	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
487214002269	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
487214002270	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
487214002271	FeS/SAM binding site; other site
487214002272	VanZ like family; Region: VanZ; pfam04892
487214002273	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
487214002274	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487214002275	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487214002276	ABC transporter; Region: ABC_tran_2; pfam12848
487214002277	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487214002278	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
487214002279	active site
487214002280	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
487214002281	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
487214002282	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
487214002283	KH domain; Region: KH_4; pfam13083
487214002284	G-X-X-G motif; other site
487214002285	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
487214002286	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
487214002287	RimM N-terminal domain; Region: RimM; pfam01782
487214002288	PRC-barrel domain; Region: PRC; pfam05239
487214002289	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
487214002290	ATP cone domain; Region: ATP-cone; pfam03477
487214002291	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
487214002292	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
487214002293	glutathione reductase; Validated; Region: PRK06116
487214002294	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487214002295	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487214002296	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
487214002297	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
487214002298	HlyD family secretion protein; Region: HlyD_3; pfam13437
487214002299	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
487214002300	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
487214002301	Walker A/P-loop; other site
487214002302	ATP binding site [chemical binding]; other site
487214002303	Q-loop/lid; other site
487214002304	ABC transporter signature motif; other site
487214002305	Walker B; other site
487214002306	D-loop; other site
487214002307	H-loop/switch region; other site
487214002308	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
487214002309	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
487214002310	FtsX-like permease family; Region: FtsX; pfam02687
487214002311	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
487214002312	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
487214002313	active site
487214002314	HIGH motif; other site
487214002315	KMSKS motif; other site
487214002316	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
487214002317	tRNA binding surface [nucleotide binding]; other site
487214002318	anticodon binding site; other site
487214002319	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
487214002320	dimer interface [polypeptide binding]; other site
487214002321	putative tRNA-binding site [nucleotide binding]; other site
487214002322	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
487214002323	Transposase; Region: DDE_Tnp_ISL3; pfam01610
487214002324	Predicted transcriptional regulators [Transcription]; Region: COG1695
487214002325	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
487214002326	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
487214002327	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
487214002328	active site
487214002329	catalytic tetrad [active]
487214002330	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
487214002331	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
487214002332	classical (c) SDRs; Region: SDR_c; cd05233
487214002333	NAD(P) binding site [chemical binding]; other site
487214002334	active site
487214002335	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
487214002336	nudix motif; other site
487214002337	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
487214002338	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
487214002339	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
487214002340	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
487214002341	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
487214002342	Zn binding site [ion binding]; other site
487214002343	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487214002344	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487214002345	active site
487214002346	phosphorylation site [posttranslational modification]
487214002347	intermolecular recognition site; other site
487214002348	dimerization interface [polypeptide binding]; other site
487214002349	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487214002350	DNA binding site [nucleotide binding]
487214002351	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487214002352	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487214002353	dimer interface [polypeptide binding]; other site
487214002354	phosphorylation site [posttranslational modification]
487214002355	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214002356	ATP binding site [chemical binding]; other site
487214002357	Mg2+ binding site [ion binding]; other site
487214002358	G-X-G motif; other site
487214002359	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
487214002360	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
487214002361	Peptidase family U32; Region: Peptidase_U32; pfam01136
487214002362	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
487214002363	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
487214002364	active site
487214002365	catalytic site [active]
487214002366	substrate binding site [chemical binding]; other site
487214002367	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487214002368	ATP binding site [chemical binding]; other site
487214002369	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
487214002370	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
487214002371	DJ-1 family protein; Region: not_thiJ; TIGR01383
487214002372	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
487214002373	conserved cys residue [active]
487214002374	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
487214002375	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214002376	motif II; other site
487214002377	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
487214002378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214002379	Mg2+ binding site [ion binding]; other site
487214002380	G-X-G motif; other site
487214002381	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
487214002382	anchoring element; other site
487214002383	dimer interface [polypeptide binding]; other site
487214002384	ATP binding site [chemical binding]; other site
487214002385	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
487214002386	active site
487214002387	putative metal-binding site [ion binding]; other site
487214002388	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
487214002389	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
487214002390	Winged helix-turn helix; Region: HTH_33; pfam13592
487214002391	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
487214002392	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
487214002393	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
487214002394	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
487214002395	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
487214002396	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
487214002397	nudix motif; other site
487214002398	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
487214002399	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214002400	Walker A motif; other site
487214002401	ATP binding site [chemical binding]; other site
487214002402	Walker B motif; other site
487214002403	arginine finger; other site
487214002404	UvrB/uvrC motif; Region: UVR; pfam02151
487214002405	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214002406	Walker A motif; other site
487214002407	ATP binding site [chemical binding]; other site
487214002408	Walker B motif; other site
487214002409	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
487214002410	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
487214002411	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
487214002412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214002413	dimer interface [polypeptide binding]; other site
487214002414	conserved gate region; other site
487214002415	putative PBP binding loops; other site
487214002416	ABC-ATPase subunit interface; other site
487214002417	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
487214002418	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
487214002419	Walker A/P-loop; other site
487214002420	ATP binding site [chemical binding]; other site
487214002421	Q-loop/lid; other site
487214002422	ABC transporter signature motif; other site
487214002423	Walker B; other site
487214002424	D-loop; other site
487214002425	H-loop/switch region; other site
487214002426	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
487214002427	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
487214002428	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
487214002429	homodimer interface [polypeptide binding]; other site
487214002430	NADP binding site [chemical binding]; other site
487214002431	substrate binding site [chemical binding]; other site
487214002432	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
487214002433	putative substrate binding site [chemical binding]; other site
487214002434	putative ATP binding site [chemical binding]; other site
487214002435	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
487214002436	tetramer (dimer of dimers) interface [polypeptide binding]; other site
487214002437	active site
487214002438	dimer interface [polypeptide binding]; other site
487214002439	phosphopentomutase; Provisional; Region: PRK05362
487214002440	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
487214002441	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
487214002442	purine nucleoside phosphorylase; Provisional; Region: PRK08202
487214002443	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
487214002444	nucleophilic elbow; other site
487214002445	catalytic triad; other site
487214002446	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
487214002447	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
487214002448	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
487214002449	topology modulation protein; Provisional; Region: PRK07261
487214002450	AAA domain; Region: AAA_17; pfam13207
487214002451	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
487214002452	pantothenate kinase; Provisional; Region: PRK05439
487214002453	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
487214002454	ATP-binding site [chemical binding]; other site
487214002455	CoA-binding site [chemical binding]; other site
487214002456	Mg2+-binding site [ion binding]; other site
487214002457	Methyltransferase domain; Region: Methyltransf_31; pfam13847
487214002458	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214002459	S-adenosylmethionine binding site [chemical binding]; other site
487214002460	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
487214002461	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
487214002462	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
487214002463	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
487214002464	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
487214002465	intersubunit interface [polypeptide binding]; other site
487214002466	active site
487214002467	catalytic residue [active]
487214002468	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
487214002469	active site
487214002470	catalytic motif [active]
487214002471	Zn binding site [ion binding]; other site
487214002472	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
487214002473	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
487214002474	ligand binding site [chemical binding]; other site
487214002475	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
487214002476	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
487214002477	Walker A/P-loop; other site
487214002478	ATP binding site [chemical binding]; other site
487214002479	Q-loop/lid; other site
487214002480	ABC transporter signature motif; other site
487214002481	Walker B; other site
487214002482	D-loop; other site
487214002483	H-loop/switch region; other site
487214002484	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
487214002485	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
487214002486	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
487214002487	TM-ABC transporter signature motif; other site
487214002488	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
487214002489	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
487214002490	TM-ABC transporter signature motif; other site
487214002491	putative transposase OrfB; Reviewed; Region: PHA02517
487214002492	HTH-like domain; Region: HTH_21; pfam13276
487214002493	Integrase core domain; Region: rve; pfam00665
487214002494	Integrase core domain; Region: rve_2; pfam13333
487214002495	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
487214002496	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
487214002497	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214002498	Mg2+ binding site [ion binding]; other site
487214002499	G-X-G motif; other site
487214002500	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
487214002501	anchoring element; other site
487214002502	dimer interface [polypeptide binding]; other site
487214002503	ATP binding site [chemical binding]; other site
487214002504	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
487214002505	active site
487214002506	putative metal-binding site [ion binding]; other site
487214002507	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
487214002508	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
487214002509	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
487214002510	CAP-like domain; other site
487214002511	active site
487214002512	primary dimer interface [polypeptide binding]; other site
487214002513	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
487214002514	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
487214002515	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
487214002516	homodimer interface [polypeptide binding]; other site
487214002517	substrate-cofactor binding pocket; other site
487214002518	catalytic residue [active]
487214002519	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
487214002520	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
487214002521	Predicted membrane protein [Function unknown]; Region: COG3819
487214002522	Predicted membrane protein [Function unknown]; Region: COG3817
487214002523	Protein of unknown function (DUF979); Region: DUF979; pfam06166
487214002524	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
487214002525	putative substrate binding pocket [chemical binding]; other site
487214002526	AC domain interface; other site
487214002527	catalytic triad [active]
487214002528	AB domain interface; other site
487214002529	interchain disulfide; other site
487214002530	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
487214002531	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
487214002532	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
487214002533	RNA binding site [nucleotide binding]; other site
487214002534	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
487214002535	RNA binding site [nucleotide binding]; other site
487214002536	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
487214002537	RNA binding site [nucleotide binding]; other site
487214002538	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
487214002539	RNA binding site [nucleotide binding]; other site
487214002540	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
487214002541	GAF domain; Region: GAF_2; pfam13185
487214002542	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
487214002543	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214002544	Walker A motif; other site
487214002545	ATP binding site [chemical binding]; other site
487214002546	Walker B motif; other site
487214002547	arginine finger; other site
487214002548	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
487214002549	Protein of unknown function (DUF3272); Region: DUF3272; pfam11676
487214002550	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
487214002551	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
487214002552	Walker A/P-loop; other site
487214002553	ATP binding site [chemical binding]; other site
487214002554	Q-loop/lid; other site
487214002555	ABC transporter signature motif; other site
487214002556	Walker B; other site
487214002557	D-loop; other site
487214002558	H-loop/switch region; other site
487214002559	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
487214002560	FeS assembly protein SufD; Region: sufD; TIGR01981
487214002561	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
487214002562	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
487214002563	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487214002564	catalytic residue [active]
487214002565	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
487214002566	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
487214002567	trimerization site [polypeptide binding]; other site
487214002568	active site
487214002569	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
487214002570	FeS assembly protein SufB; Region: sufB; TIGR01980
487214002571	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
487214002572	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
487214002573	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
487214002574	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
487214002575	Domain of unknown function DUF20; Region: UPF0118; pfam01594
487214002576	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
487214002577	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
487214002578	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
487214002579	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
487214002580	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
487214002581	putative substrate binding site [chemical binding]; other site
487214002582	putative ATP binding site [chemical binding]; other site
487214002583	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
487214002584	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
487214002585	active site
487214002586	phosphorylation site [posttranslational modification]
487214002587	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
487214002588	active site
487214002589	P-loop; other site
487214002590	phosphorylation site [posttranslational modification]
487214002591	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
487214002592	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
487214002593	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
487214002594	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487214002595	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
487214002596	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
487214002597	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
487214002598	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487214002599	catalytic residue [active]
487214002600	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
487214002601	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
487214002602	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
487214002603	Ligand Binding Site [chemical binding]; other site
487214002604	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
487214002605	Putative esterase; Region: Esterase; pfam00756
487214002606	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
487214002607	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
487214002608	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
487214002609	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
487214002610	HsdM N-terminal domain; Region: HsdM_N; pfam12161
487214002611	Methyltransferase domain; Region: Methyltransf_26; pfam13659
487214002612	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
487214002613	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
487214002614	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
487214002615	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
487214002616	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
487214002617	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
487214002618	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
487214002619	active site
487214002620	catalytic residues [active]
487214002621	DNA binding site [nucleotide binding]
487214002622	Int/Topo IB signature motif; other site
487214002623	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
487214002624	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
487214002625	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
487214002626	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
487214002627	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
487214002628	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
487214002629	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487214002630	ATP binding site [chemical binding]; other site
487214002631	putative Mg++ binding site [ion binding]; other site
487214002632	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
487214002633	Arginine repressor [Transcription]; Region: ArgR; COG1438
487214002634	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
487214002635	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
487214002636	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
487214002637	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
487214002638	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
487214002639	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
487214002640	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
487214002641	active site
487214002642	PHP Thumb interface [polypeptide binding]; other site
487214002643	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
487214002644	generic binding surface II; other site
487214002645	generic binding surface I; other site
487214002646	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
487214002647	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
487214002648	active site
487214002649	ADP/pyrophosphate binding site [chemical binding]; other site
487214002650	dimerization interface [polypeptide binding]; other site
487214002651	allosteric effector site; other site
487214002652	fructose-1,6-bisphosphate binding site; other site
487214002653	pyruvate kinase; Provisional; Region: PRK05826
487214002654	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
487214002655	domain interfaces; other site
487214002656	active site
487214002657	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
487214002658	Domain of unknown function (DUF4300); Region: DUF4300; pfam14133
487214002659	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
487214002660	Predicted membrane protein [Function unknown]; Region: COG3689
487214002661	Predicted permeases [General function prediction only]; Region: COG0701
487214002662	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
487214002663	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
487214002664	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
487214002665	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
487214002666	RNA binding site [nucleotide binding]; other site
487214002667	SprT homologues; Region: SprT; cl01182
487214002668	hypothetical protein; Provisional; Region: PRK04351
487214002669	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
487214002670	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
487214002671	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
487214002672	Walker A/P-loop; other site
487214002673	ATP binding site [chemical binding]; other site
487214002674	Q-loop/lid; other site
487214002675	ABC transporter signature motif; other site
487214002676	Walker B; other site
487214002677	D-loop; other site
487214002678	H-loop/switch region; other site
487214002679	FtsX-like permease family; Region: FtsX; pfam02687
487214002680	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
487214002681	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
487214002682	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
487214002683	homodimer interface [polypeptide binding]; other site
487214002684	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487214002685	catalytic residue [active]
487214002686	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
487214002687	spermidine synthase; Provisional; Region: PRK00811
487214002688	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214002689	S-adenosylmethionine binding site [chemical binding]; other site
487214002690	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
487214002691	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488
487214002692	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
487214002693	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
487214002694	dimer interface [polypeptide binding]; other site
487214002695	active site
487214002696	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
487214002697	catalytic residues [active]
487214002698	substrate binding site [chemical binding]; other site
487214002699	agmatine deiminase; Provisional; Region: PRK13551
487214002700	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
487214002701	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
487214002702	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
487214002703	putative active site; other site
487214002704	catalytic triad [active]
487214002705	putative dimer interface [polypeptide binding]; other site
487214002706	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214002707	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
487214002708	active site
487214002709	motif I; other site
487214002710	motif II; other site
487214002711	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214002712	CAAX protease self-immunity; Region: Abi; pfam02517
487214002713	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
487214002714	Transcriptional regulator [Transcription]; Region: LysR; COG0583
487214002715	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
487214002716	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
487214002717	dimerization interface [polypeptide binding]; other site
487214002718	lipoprotein signal peptidase; Provisional; Region: PRK14797
487214002719	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
487214002720	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
487214002721	RNA binding surface [nucleotide binding]; other site
487214002722	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
487214002723	active site
487214002724	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
487214002725	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
487214002726	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
487214002727	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
487214002728	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
487214002729	nucleotide binding site [chemical binding]; other site
487214002730	homotetrameric interface [polypeptide binding]; other site
487214002731	putative phosphate binding site [ion binding]; other site
487214002732	putative allosteric binding site; other site
487214002733	PUA domain; Region: PUA; pfam01472
487214002734	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
487214002735	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
487214002736	putative catalytic cysteine [active]
487214002737	pyrroline-5-carboxylate reductase; Region: PLN02688
487214002738	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
487214002739	thymidylate kinase; Validated; Region: tmk; PRK00698
487214002740	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
487214002741	TMP-binding site; other site
487214002742	ATP-binding site [chemical binding]; other site
487214002743	DNA polymerase III subunit delta'; Validated; Region: PRK07276
487214002744	DNA polymerase III subunit delta'; Validated; Region: PRK08485
487214002745	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
487214002746	Predicted methyltransferases [General function prediction only]; Region: COG0313
487214002747	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
487214002748	putative SAM binding site [chemical binding]; other site
487214002749	putative homodimer interface [polypeptide binding]; other site
487214002750	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
487214002751	Glucose inhibited division protein A; Region: GIDA; pfam01134
487214002752	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
487214002753	putative nucleotide binding site [chemical binding]; other site
487214002754	uridine monophosphate binding site [chemical binding]; other site
487214002755	homohexameric interface [polypeptide binding]; other site
487214002756	ribosome recycling factor; Reviewed; Region: frr; PRK00083
487214002757	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
487214002758	hinge region; other site
487214002759	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
487214002760	S1 domain; Region: S1_2; pfam13509
487214002761	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
487214002762	hypothetical protein; Provisional; Region: PRK13672
487214002763	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
487214002764	PhoH-like protein; Region: PhoH; pfam02562
487214002765	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
487214002766	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
487214002767	SLBB domain; Region: SLBB; pfam10531
487214002768	comEA protein; Region: comE; TIGR01259
487214002769	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
487214002770	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
487214002771	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
487214002772	Competence protein; Region: Competence; pfam03772
487214002773	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
487214002774	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
487214002775	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
487214002776	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
487214002777	Walker A/P-loop; other site
487214002778	ATP binding site [chemical binding]; other site
487214002779	Q-loop/lid; other site
487214002780	ABC transporter signature motif; other site
487214002781	Walker B; other site
487214002782	D-loop; other site
487214002783	H-loop/switch region; other site
487214002784	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
487214002785	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
487214002786	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
487214002787	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
487214002788	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
487214002789	23S rRNA binding site [nucleotide binding]; other site
487214002790	L21 binding site [polypeptide binding]; other site
487214002791	L13 binding site [polypeptide binding]; other site
487214002792	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487214002793	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
487214002794	dimer interface [polypeptide binding]; other site
487214002795	active site
487214002796	metal binding site [ion binding]; metal-binding site
487214002797	glutathione binding site [chemical binding]; other site
487214002798	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
487214002799	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
487214002800	FAD binding pocket [chemical binding]; other site
487214002801	FAD binding motif [chemical binding]; other site
487214002802	phosphate binding motif [ion binding]; other site
487214002803	beta-alpha-beta structure motif; other site
487214002804	NAD binding pocket [chemical binding]; other site
487214002805	Iron coordination center [ion binding]; other site
487214002806	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
487214002807	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
487214002808	heterodimer interface [polypeptide binding]; other site
487214002809	active site
487214002810	FMN binding site [chemical binding]; other site
487214002811	homodimer interface [polypeptide binding]; other site
487214002812	substrate binding site [chemical binding]; other site
487214002813	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
487214002814	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
487214002815	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
487214002816	Domain of unknown function (DUF814); Region: DUF814; pfam05670
487214002817	metal-binding heat shock protein; Provisional; Region: PRK00016
487214002818	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
487214002819	GTPase Era; Reviewed; Region: era; PRK00089
487214002820	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
487214002821	G1 box; other site
487214002822	GTP/Mg2+ binding site [chemical binding]; other site
487214002823	Switch I region; other site
487214002824	G2 box; other site
487214002825	Switch II region; other site
487214002826	G3 box; other site
487214002827	G4 box; other site
487214002828	G5 box; other site
487214002829	KH domain; Region: KH_2; pfam07650
487214002830	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
487214002831	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
487214002832	DNA binding site [nucleotide binding]
487214002833	catalytic residue [active]
487214002834	H2TH interface [polypeptide binding]; other site
487214002835	putative catalytic residues [active]
487214002836	turnover-facilitating residue; other site
487214002837	intercalation triad [nucleotide binding]; other site
487214002838	8OG recognition residue [nucleotide binding]; other site
487214002839	putative reading head residues; other site
487214002840	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
487214002841	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
487214002842	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
487214002843	dephospho-CoA kinase; Region: TIGR00152
487214002844	CoA-binding site [chemical binding]; other site
487214002845	ATP-binding [chemical binding]; other site
487214002846	drug efflux system protein MdtG; Provisional; Region: PRK09874
487214002847	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487214002848	putative substrate translocation pore; other site
487214002849	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
487214002850	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
487214002851	ribonuclease R; Region: RNase_R; TIGR02063
487214002852	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
487214002853	RNB domain; Region: RNB; pfam00773
487214002854	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
487214002855	RNA binding site [nucleotide binding]; other site
487214002856	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
487214002857	SmpB-tmRNA interface; other site
487214002858	tellurite resistance protein TehB; Provisional; Region: PRK12335
487214002859	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
487214002860	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214002861	S-adenosylmethionine binding site [chemical binding]; other site
487214002862	Competence protein CoiA-like family; Region: CoiA; cl11541
487214002863	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
487214002864	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
487214002865	active site
487214002866	Zn binding site [ion binding]; other site
487214002867	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
487214002868	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214002869	S-adenosylmethionine binding site [chemical binding]; other site
487214002870	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
487214002871	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
487214002872	Integrase core domain; Region: rve; pfam00665
487214002873	Integrase core domain; Region: rve_2; pfam13333
487214002874	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
487214002875	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487214002876	catalytic core [active]
487214002877	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
487214002878	putative deacylase active site [active]
487214002879	Predicted membrane protein [Function unknown]; Region: COG2035
487214002880	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
487214002881	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
487214002882	active site
487214002883	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
487214002884	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
487214002885	Substrate binding site; other site
487214002886	Mg++ binding site; other site
487214002887	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
487214002888	active site
487214002889	substrate binding site [chemical binding]; other site
487214002890	CoA binding site [chemical binding]; other site
487214002891	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
487214002892	dimer interface [polypeptide binding]; other site
487214002893	ADP-ribose binding site [chemical binding]; other site
487214002894	active site
487214002895	nudix motif; other site
487214002896	metal binding site [ion binding]; metal-binding site
487214002897	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
487214002898	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
487214002899	MarR family; Region: MarR_2; cl17246
487214002900	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
487214002901	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
487214002902	active site
487214002903	catalytic site [active]
487214002904	substrate binding site [chemical binding]; other site
487214002905	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
487214002906	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
487214002907	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
487214002908	putative active site [active]
487214002909	catalytic site [active]
487214002910	putative metal binding site [ion binding]; other site
487214002911	DDE superfamily endonuclease; Region: DDE_3; pfam13358
487214002912	Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases; Region: TM_EGFR-like; cl17045
487214002913	dimer interface [polypeptide binding]; other site
487214002914	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
487214002915	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
487214002916	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
487214002917	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
487214002918	catalytic residues [active]
487214002919	amino acid transporter; Region: 2A0306; TIGR00909
487214002920	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
487214002921	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
487214002922	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
487214002923	metal binding site [ion binding]; metal-binding site
487214002924	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
487214002925	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
487214002926	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
487214002927	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
487214002928	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
487214002929	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
487214002930	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
487214002931	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
487214002932	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
487214002933	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
487214002934	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
487214002935	peptidase T; Region: peptidase-T; TIGR01882
487214002936	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
487214002937	metal binding site [ion binding]; metal-binding site
487214002938	dimer interface [polypeptide binding]; other site
487214002939	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
487214002940	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
487214002941	C-terminal domain interface [polypeptide binding]; other site
487214002942	active site
487214002943	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
487214002944	active site
487214002945	N-terminal domain interface [polypeptide binding]; other site
487214002946	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
487214002947	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
487214002948	Predicted membrane protein [Function unknown]; Region: COG2246
487214002949	GtrA-like protein; Region: GtrA; pfam04138
487214002950	Predicted membrane protein [Function unknown]; Region: COG4708
487214002951	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
487214002952	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
487214002953	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
487214002954	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
487214002955	dimer interface [polypeptide binding]; other site
487214002956	active site
487214002957	catalytic residue [active]
487214002958	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
487214002959	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
487214002960	trmE is a tRNA modification GTPase; Region: trmE; cd04164
487214002961	G1 box; other site
487214002962	GTP/Mg2+ binding site [chemical binding]; other site
487214002963	Switch I region; other site
487214002964	G2 box; other site
487214002965	Switch II region; other site
487214002966	G3 box; other site
487214002967	G4 box; other site
487214002968	G5 box; other site
487214002969	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
487214002970	4-oxalocrotonate tautomerase; Provisional; Region: PRK02289
487214002971	active site 1 [active]
487214002972	dimer interface [polypeptide binding]; other site
487214002973	hexamer interface [polypeptide binding]; other site
487214002974	active site 2 [active]
487214002975	thymidine kinase; Provisional; Region: PRK04296
487214002976	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
487214002977	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487214002978	Coenzyme A binding pocket [chemical binding]; other site
487214002979	peptide chain release factor 1; Validated; Region: prfA; PRK00591
487214002980	This domain is found in peptide chain release factors; Region: PCRF; smart00937
487214002981	RF-1 domain; Region: RF-1; pfam00472
487214002982	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
487214002983	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214002984	S-adenosylmethionine binding site [chemical binding]; other site
487214002985	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
487214002986	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
487214002987	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487214002988	Coenzyme A binding pocket [chemical binding]; other site
487214002989	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
487214002990	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
487214002991	dimer interface [polypeptide binding]; other site
487214002992	active site
487214002993	glycine-pyridoxal phosphate binding site [chemical binding]; other site
487214002994	folate binding site [chemical binding]; other site
487214002995	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
487214002996	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
487214002997	Lysozyme-like; Region: Lysozyme_like; pfam13702
487214002998	catalytic residue [active]
487214002999	Predicted secreted protein [Function unknown]; Region: COG4086
487214003000	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
487214003001	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
487214003002	TRAM domain; Region: TRAM; cl01282
487214003003	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214003004	S-adenosylmethionine binding site [chemical binding]; other site
487214003005	Predicted transcriptional regulator [Transcription]; Region: COG3655
487214003006	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
487214003007	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
487214003008	siderophore binding site; other site
487214003009	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
487214003010	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
487214003011	ABC-ATPase subunit  interface; other site
487214003012	dimer interface [polypeptide binding]; other site
487214003013	putative PBP binding regions; other site
487214003014	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
487214003015	ABC-ATPase subunit  interface; other site
487214003016	dimer interface [polypeptide binding]; other site
487214003017	putative PBP binding regions; other site
487214003018	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
487214003019	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
487214003020	Walker A/P-loop; other site
487214003021	ATP binding site [chemical binding]; other site
487214003022	Q-loop/lid; other site
487214003023	ABC transporter signature motif; other site
487214003024	Walker B; other site
487214003025	D-loop; other site
487214003026	H-loop/switch region; other site
487214003027	Protein of unknown function (DUF1603); Region: DUF1603; pfam07674
487214003028	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
487214003029	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
487214003030	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
487214003031	catalytic residues [active]
487214003032	catalytic nucleophile [active]
487214003033	Recombinase; Region: Recombinase; pfam07508
487214003034	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
487214003035	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
487214003036	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
487214003037	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
487214003038	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
487214003039	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
487214003040	homodimer interface [polypeptide binding]; other site
487214003041	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
487214003042	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
487214003043	active site
487214003044	homodimer interface [polypeptide binding]; other site
487214003045	catalytic site [active]
487214003046	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487214003047	Coenzyme A binding pocket [chemical binding]; other site
487214003048	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
487214003049	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
487214003050	conserved cys residue [active]
487214003051	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
487214003052	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
487214003053	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
487214003054	T-box leader
487214003055	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
487214003056	zinc binding site [ion binding]; other site
487214003057	putative ligand binding site [chemical binding]; other site
487214003058	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
487214003059	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
487214003060	TM-ABC transporter signature motif; other site
487214003061	DNA primase; Validated; Region: dnaG; PRK05667
487214003062	CHC2 zinc finger; Region: zf-CHC2; pfam01807
487214003063	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
487214003064	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
487214003065	active site
487214003066	metal binding site [ion binding]; metal-binding site
487214003067	interdomain interaction site; other site
487214003068	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
487214003069	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
487214003070	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
487214003071	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
487214003072	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
487214003073	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487214003074	DNA binding residues [nucleotide binding]
487214003075	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
487214003076	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487214003077	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
487214003078	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487214003079	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
487214003080	putative ADP-binding pocket [chemical binding]; other site
487214003081	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
487214003082	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
487214003083	GTPase CgtA; Reviewed; Region: obgE; PRK12297
487214003084	GTP1/OBG; Region: GTP1_OBG; pfam01018
487214003085	Obg GTPase; Region: Obg; cd01898
487214003086	G1 box; other site
487214003087	GTP/Mg2+ binding site [chemical binding]; other site
487214003088	Switch I region; other site
487214003089	G2 box; other site
487214003090	G3 box; other site
487214003091	Switch II region; other site
487214003092	G4 box; other site
487214003093	G5 box; other site
487214003094	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
487214003095	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
487214003096	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
487214003097	hinge; other site
487214003098	active site
487214003099	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
487214003100	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
487214003101	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
487214003102	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487214003103	DNA-binding site [nucleotide binding]; DNA binding site
487214003104	DRTGG domain; Region: DRTGG; pfam07085
487214003105	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
487214003106	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
487214003107	active site 2 [active]
487214003108	active site 1 [active]
487214003109	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
487214003110	active site
487214003111	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
487214003112	Part of AAA domain; Region: AAA_19; pfam13245
487214003113	Family description; Region: UvrD_C_2; pfam13538
487214003114	hypothetical protein; Reviewed; Region: PRK00024
487214003115	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
487214003116	MPN+ (JAMM) motif; other site
487214003117	Zinc-binding site [ion binding]; other site
487214003118	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
487214003119	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
487214003120	catalytic triad [active]
487214003121	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
487214003122	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
487214003123	CoA binding domain; Region: CoA_binding; pfam02629
487214003124	Putative amino acid metabolism; Region: DUF1831; pfam08866
487214003125	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
487214003126	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
487214003127	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
487214003128	catalytic residue [active]
487214003129	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
487214003130	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
487214003131	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487214003132	active site
487214003133	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
487214003134	putative active site [active]
487214003135	putative metal binding residues [ion binding]; other site
487214003136	signature motif; other site
487214003137	putative triphosphate binding site [ion binding]; other site
487214003138	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
487214003139	synthetase active site [active]
487214003140	NTP binding site [chemical binding]; other site
487214003141	metal binding site [ion binding]; metal-binding site
487214003142	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
487214003143	ATP-NAD kinase; Region: NAD_kinase; pfam01513
487214003144	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
487214003145	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
487214003146	RNA binding surface [nucleotide binding]; other site
487214003147	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
487214003148	active site
487214003149	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
487214003150	hypothetical protein; Validated; Region: PRK00153
487214003151	Predicted membrane protein [Function unknown]; Region: COG3619
487214003152	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
487214003153	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
487214003154	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
487214003155	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
487214003156	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
487214003157	active site
487214003158	Riboflavin kinase; Region: Flavokinase; smart00904
487214003159	Uncharacterized conserved protein [Function unknown]; Region: COG1284
487214003160	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
487214003161	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
487214003162	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
487214003163	EDD domain protein, DegV family; Region: DegV; TIGR00762
487214003164	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
487214003165	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
487214003166	IHF dimer interface [polypeptide binding]; other site
487214003167	IHF - DNA interface [nucleotide binding]; other site
487214003168	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
487214003169	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487214003170	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487214003171	ABC transporter; Region: ABC_tran_2; pfam12848
487214003172	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487214003173	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214003174	non-specific DNA binding site [nucleotide binding]; other site
487214003175	salt bridge; other site
487214003176	sequence-specific DNA binding site [nucleotide binding]; other site
487214003177	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
487214003178	H+ Antiporter protein; Region: 2A0121; TIGR00900
487214003179	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487214003180	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
487214003181	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
487214003182	nucleotide binding pocket [chemical binding]; other site
487214003183	K-X-D-G motif; other site
487214003184	catalytic site [active]
487214003185	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
487214003186	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
487214003187	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
487214003188	Dimer interface [polypeptide binding]; other site
487214003189	BRCT sequence motif; other site
487214003190	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227
487214003191	pullulanase, type I; Region: pulA_typeI; TIGR02104
487214003192	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
487214003193	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
487214003194	Ca binding site [ion binding]; other site
487214003195	active site
487214003196	catalytic site [active]
487214003197	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
487214003198	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
487214003199	tetrameric interface [polypeptide binding]; other site
487214003200	activator binding site; other site
487214003201	NADP binding site [chemical binding]; other site
487214003202	substrate binding site [chemical binding]; other site
487214003203	catalytic residues [active]
487214003204	glycogen branching enzyme; Provisional; Region: PRK12313
487214003205	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
487214003206	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
487214003207	active site
487214003208	catalytic site [active]
487214003209	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
487214003210	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
487214003211	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
487214003212	ligand binding site; other site
487214003213	oligomer interface; other site
487214003214	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
487214003215	dimer interface [polypeptide binding]; other site
487214003216	N-terminal domain interface [polypeptide binding]; other site
487214003217	sulfate 1 binding site; other site
487214003218	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
487214003219	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
487214003220	active site
487214003221	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
487214003222	dimer interface [polypeptide binding]; other site
487214003223	N-terminal domain interface [polypeptide binding]; other site
487214003224	sulfate 1 binding site; other site
487214003225	glycogen synthase; Provisional; Region: glgA; PRK00654
487214003226	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
487214003227	ADP-binding pocket [chemical binding]; other site
487214003228	homodimer interface [polypeptide binding]; other site
487214003229	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
487214003230	Uncharacterized conserved protein [Function unknown]; Region: COG5506
487214003231	enolase; Provisional; Region: eno; PRK00077
487214003232	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
487214003233	dimer interface [polypeptide binding]; other site
487214003234	metal binding site [ion binding]; metal-binding site
487214003235	substrate binding pocket [chemical binding]; other site
487214003236	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
487214003237	DNA binding site [nucleotide binding]
487214003238	active site
487214003239	Int/Topo IB signature motif; other site
487214003240	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
487214003241	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
487214003242	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
487214003243	Part of AAA domain; Region: AAA_19; pfam13245
487214003244	Family description; Region: UvrD_C_2; pfam13538
487214003245	Family description; Region: UvrD_C_2; pfam13538
487214003246	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
487214003247	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
487214003248	G5 domain; Region: G5; pfam07501
487214003249	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
487214003250	The GLUG motif; Region: Glug; pfam07581
487214003251	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
487214003252	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
487214003253	Transposase; Region: DDE_Tnp_ISL3; pfam01610
487214003254	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
487214003255	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
487214003256	cofactor binding site; other site
487214003257	DNA binding site [nucleotide binding]
487214003258	substrate interaction site [chemical binding]; other site
487214003259	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
487214003260	Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393
487214003261	ArsC family; Region: ArsC; pfam03960
487214003262	CAAX protease self-immunity; Region: Abi; pfam02517
487214003263	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
487214003264	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
487214003265	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
487214003266	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
487214003267	Walker A motif; other site
487214003268	ATP binding site [chemical binding]; other site
487214003269	Walker B motif; other site
487214003270	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
487214003271	PrgI family protein; Region: PrgI; pfam12666
487214003272	AAA-like domain; Region: AAA_10; pfam12846
487214003273	Peptidase family M23; Region: Peptidase_M23; pfam01551
487214003274	CHAP domain; Region: CHAP; pfam05257
487214003275	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
487214003276	heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1); Region: Ebola_HIV-1-like_HR1-HR2; cl02885
487214003277	HR1; other site
487214003278	homotrimer interface [polypeptide binding]; other site
487214003279	immunosuppressive region; other site
487214003280	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446
487214003281	GIY-YIG motif/motif A; other site
487214003282	putative active site [active]
487214003283	putative metal binding site [ion binding]; other site
487214003284	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
487214003285	Toprim-like; Region: Toprim_2; pfam13155
487214003286	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
487214003287	Zeta toxin; Region: Zeta_toxin; pfam06414
487214003288	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
487214003289	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
487214003290	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
487214003291	GIY-YIG motif/motif A; other site
487214003292	active site
487214003293	catalytic site [active]
487214003294	Chloramphenicol acetyltransferase; Region: CAT; pfam00302
487214003295	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
487214003296	Replication protein; Region: Rep_1; cl02412
487214003297	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
487214003298	homodimer interface [polypeptide binding]; other site
487214003299	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
487214003300	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
487214003301	active site
487214003302	homodimer interface [polypeptide binding]; other site
487214003303	catalytic site [active]
487214003304	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
487214003305	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
487214003306	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
487214003307	GTP/Mg2+ binding site [chemical binding]; other site
487214003308	G4 box; other site
487214003309	G5 box; other site
487214003310	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
487214003311	G1 box; other site
487214003312	G1 box; other site
487214003313	GTP/Mg2+ binding site [chemical binding]; other site
487214003314	Switch I region; other site
487214003315	G2 box; other site
487214003316	G2 box; other site
487214003317	G3 box; other site
487214003318	G3 box; other site
487214003319	Switch II region; other site
487214003320	Switch II region; other site
487214003321	G5 box; other site
487214003322	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
487214003323	RNA/DNA hybrid binding site [nucleotide binding]; other site
487214003324	active site
487214003325	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
487214003326	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
487214003327	Cl- selectivity filter; other site
487214003328	Cl- binding residues [ion binding]; other site
487214003329	pore gating glutamate residue; other site
487214003330	dimer interface [polypeptide binding]; other site
487214003331	H+/Cl- coupling transport residue; other site
487214003332	TrkA-C domain; Region: TrkA_C; pfam02080
487214003333	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
487214003334	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
487214003335	active site
487214003336	DNA binding site [nucleotide binding]
487214003337	Int/Topo IB signature motif; other site
487214003338	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
487214003339	Helix-turn-helix domain; Region: HTH_28; pfam13518
487214003340	Transposase; Region: HTH_Tnp_1; cl17663
487214003341	HTH-like domain; Region: HTH_21; pfam13276
487214003342	Integrase core domain; Region: rve; pfam00665
487214003343	Integrase core domain; Region: rve_2; pfam13333
487214003344	multidrug efflux protein; Reviewed; Region: PRK01766
487214003345	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
487214003346	cation binding site [ion binding]; other site
487214003347	dihydroorotase; Validated; Region: pyrC; PRK09357
487214003348	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
487214003349	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
487214003350	active site
487214003351	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
487214003352	putative active site [active]
487214003353	nucleotide binding site [chemical binding]; other site
487214003354	nudix motif; other site
487214003355	putative metal binding site [ion binding]; other site
487214003356	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
487214003357	ligand binding site [chemical binding]; other site
487214003358	active site
487214003359	UGI interface [polypeptide binding]; other site
487214003360	catalytic site [active]
487214003361	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
487214003362	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214003363	motif II; other site
487214003364	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
487214003365	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
487214003366	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214003367	Walker A/P-loop; other site
487214003368	ATP binding site [chemical binding]; other site
487214003369	Q-loop/lid; other site
487214003370	ABC transporter signature motif; other site
487214003371	Walker B; other site
487214003372	D-loop; other site
487214003373	H-loop/switch region; other site
487214003374	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214003375	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
487214003376	Walker A/P-loop; other site
487214003377	ATP binding site [chemical binding]; other site
487214003378	Q-loop/lid; other site
487214003379	ABC transporter signature motif; other site
487214003380	Walker B; other site
487214003381	D-loop; other site
487214003382	H-loop/switch region; other site
487214003383	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487214003384	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487214003385	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
487214003386	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
487214003387	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
487214003388	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
487214003389	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
487214003390	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487214003391	DhaKLM operon coactivator DhaQ; Provisional; Region: PRK14483
487214003392	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
487214003393	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
487214003394	Flagellin N-methylase; Region: FliB; pfam03692
487214003395	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
487214003396	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
487214003397	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
487214003398	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
487214003399	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
487214003400	dimerization domain swap beta strand [polypeptide binding]; other site
487214003401	regulatory protein interface [polypeptide binding]; other site
487214003402	active site
487214003403	regulatory phosphorylation site [posttranslational modification]; other site
487214003404	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
487214003405	catalytic residues [active]
487214003406	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
487214003407	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
487214003408	Class I ribonucleotide reductase; Region: RNR_I; cd01679
487214003409	active site
487214003410	dimer interface [polypeptide binding]; other site
487214003411	catalytic residues [active]
487214003412	effector binding site; other site
487214003413	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
487214003414	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
487214003415	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
487214003416	dimer interface [polypeptide binding]; other site
487214003417	putative radical transfer pathway; other site
487214003418	diiron center [ion binding]; other site
487214003419	tyrosyl radical; other site
487214003420	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
487214003421	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
487214003422	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
487214003423	Protein of unknown function (DUF3884); Region: DUF3884; pfam13024
487214003424	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
487214003425	beta-galactosidase; Region: BGL; TIGR03356
487214003426	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
487214003427	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
487214003428	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
487214003429	active site
487214003430	P-loop; other site
487214003431	phosphorylation site [posttranslational modification]
487214003432	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
487214003433	methionine cluster; other site
487214003434	active site
487214003435	phosphorylation site [posttranslational modification]
487214003436	metal binding site [ion binding]; metal-binding site
487214003437	CAT RNA binding domain; Region: CAT_RBD; smart01061
487214003438	transcriptional antiterminator BglG; Provisional; Region: PRK09772
487214003439	PRD domain; Region: PRD; pfam00874
487214003440	PRD domain; Region: PRD; pfam00874
487214003441	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
487214003442	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
487214003443	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
487214003444	putative substrate binding site [chemical binding]; other site
487214003445	putative ATP binding site [chemical binding]; other site
487214003446	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
487214003447	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
487214003448	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
487214003449	catalytic residues [active]
487214003450	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
487214003451	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
487214003452	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
487214003453	active site
487214003454	P-loop; other site
487214003455	phosphorylation site [posttranslational modification]
487214003456	GTP-binding protein LepA; Provisional; Region: PRK05433
487214003457	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
487214003458	G1 box; other site
487214003459	putative GEF interaction site [polypeptide binding]; other site
487214003460	GTP/Mg2+ binding site [chemical binding]; other site
487214003461	Switch I region; other site
487214003462	G2 box; other site
487214003463	G3 box; other site
487214003464	Switch II region; other site
487214003465	G4 box; other site
487214003466	G5 box; other site
487214003467	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
487214003468	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
487214003469	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
487214003470	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
487214003471	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
487214003472	active site
487214003473	metal binding site [ion binding]; metal-binding site
487214003474	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
487214003475	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
487214003476	Walker A/P-loop; other site
487214003477	ATP binding site [chemical binding]; other site
487214003478	Q-loop/lid; other site
487214003479	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
487214003480	ABC transporter signature motif; other site
487214003481	Walker B; other site
487214003482	D-loop; other site
487214003483	H-loop/switch region; other site
487214003484	Arginine repressor [Transcription]; Region: ArgR; COG1438
487214003485	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
487214003486	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
487214003487	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
487214003488	S4 RNA-binding domain; Region: S4; smart00363
487214003489	RNA binding surface [nucleotide binding]; other site
487214003490	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
487214003491	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
487214003492	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
487214003493	substrate binding pocket [chemical binding]; other site
487214003494	chain length determination region; other site
487214003495	substrate-Mg2+ binding site; other site
487214003496	catalytic residues [active]
487214003497	aspartate-rich region 1; other site
487214003498	active site lid residues [active]
487214003499	aspartate-rich region 2; other site
487214003500	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
487214003501	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
487214003502	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
487214003503	generic binding surface II; other site
487214003504	generic binding surface I; other site
487214003505	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
487214003506	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
487214003507	Sugar specificity; other site
487214003508	Pyrimidine base specificity; other site
487214003509	ATP-binding site [chemical binding]; other site
487214003510	Enterocin A Immunity; Region: EntA_Immun; pfam08951
487214003511	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
487214003512	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
487214003513	RNA binding site [nucleotide binding]; other site
487214003514	active site
487214003515	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
487214003516	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
487214003517	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
487214003518	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
487214003519	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
487214003520	active site
487214003521	catalytic site [active]
487214003522	DNA gyrase subunit A; Validated; Region: PRK05560
487214003523	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
487214003524	CAP-like domain; other site
487214003525	active site
487214003526	primary dimer interface [polypeptide binding]; other site
487214003527	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
487214003528	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
487214003529	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
487214003530	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
487214003531	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
487214003532	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
487214003533	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
487214003534	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
487214003535	tetramer (dimer of dimers) interface [polypeptide binding]; other site
487214003536	NAD binding site [chemical binding]; other site
487214003537	dimer interface [polypeptide binding]; other site
487214003538	substrate binding site [chemical binding]; other site
487214003539	Ion channel; Region: Ion_trans_2; pfam07885
487214003540	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
487214003541	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
487214003542	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
487214003543	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
487214003544	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
487214003545	putative active site [active]
487214003546	heme pocket [chemical binding]; other site
487214003547	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487214003548	dimer interface [polypeptide binding]; other site
487214003549	phosphorylation site [posttranslational modification]
487214003550	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214003551	ATP binding site [chemical binding]; other site
487214003552	Mg2+ binding site [ion binding]; other site
487214003553	G-X-G motif; other site
487214003554	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487214003555	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487214003556	active site
487214003557	phosphorylation site [posttranslational modification]
487214003558	intermolecular recognition site; other site
487214003559	dimerization interface [polypeptide binding]; other site
487214003560	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487214003561	DNA binding site [nucleotide binding]
487214003562	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
487214003563	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
487214003564	minor groove reading motif; other site
487214003565	helix-hairpin-helix signature motif; other site
487214003566	substrate binding pocket [chemical binding]; other site
487214003567	active site
487214003568	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
487214003569	DNA binding and oxoG recognition site [nucleotide binding]
487214003570	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
487214003571	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
487214003572	Potassium binding sites [ion binding]; other site
487214003573	Cesium cation binding sites [ion binding]; other site
487214003574	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
487214003575	phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113
487214003576	Flavoprotein; Region: Flavoprotein; pfam02441
487214003577	Predicted membrane protein [Function unknown]; Region: COG4684
487214003578	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
487214003579	HTH domain; Region: HTH_11; pfam08279
487214003580	3H domain; Region: 3H; pfam02829
487214003581	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
487214003582	putative active site [active]
487214003583	nucleotide binding site [chemical binding]; other site
487214003584	nudix motif; other site
487214003585	putative metal binding site [ion binding]; other site
487214003586	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
487214003587	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487214003588	Coenzyme A binding pocket [chemical binding]; other site
487214003589	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
487214003590	excinuclease ABC subunit B; Provisional; Region: PRK05298
487214003591	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487214003592	ATP binding site [chemical binding]; other site
487214003593	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487214003594	nucleotide binding region [chemical binding]; other site
487214003595	ATP-binding site [chemical binding]; other site
487214003596	Ultra-violet resistance protein B; Region: UvrB; pfam12344
487214003597	UvrB/uvrC motif; Region: UVR; pfam02151
487214003598	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
487214003599	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
487214003600	substrate binding pocket [chemical binding]; other site
487214003601	membrane-bound complex binding site; other site
487214003602	hinge residues; other site
487214003603	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
487214003604	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
487214003605	substrate binding pocket [chemical binding]; other site
487214003606	membrane-bound complex binding site; other site
487214003607	hinge residues; other site
487214003608	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214003609	dimer interface [polypeptide binding]; other site
487214003610	conserved gate region; other site
487214003611	putative PBP binding loops; other site
487214003612	ABC-ATPase subunit interface; other site
487214003613	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
487214003614	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
487214003615	Walker A/P-loop; other site
487214003616	ATP binding site [chemical binding]; other site
487214003617	Q-loop/lid; other site
487214003618	ABC transporter signature motif; other site
487214003619	Walker B; other site
487214003620	D-loop; other site
487214003621	H-loop/switch region; other site
487214003622	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
487214003623	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
487214003624	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
487214003625	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
487214003626	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
487214003627	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
487214003628	P loop; other site
487214003629	GTP binding site [chemical binding]; other site
487214003630	sugar phosphate phosphatase; Provisional; Region: PRK10513
487214003631	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214003632	motif II; other site
487214003633	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
487214003634	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
487214003635	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214003636	active site
487214003637	motif I; other site
487214003638	motif II; other site
487214003639	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
487214003640	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
487214003641	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
487214003642	Walker A/P-loop; other site
487214003643	ATP binding site [chemical binding]; other site
487214003644	Q-loop/lid; other site
487214003645	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
487214003646	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
487214003647	ABC transporter signature motif; other site
487214003648	Walker B; other site
487214003649	D-loop; other site
487214003650	H-loop/switch region; other site
487214003651	ribonuclease III; Reviewed; Region: rnc; PRK00102
487214003652	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
487214003653	dimerization interface [polypeptide binding]; other site
487214003654	active site
487214003655	metal binding site [ion binding]; metal-binding site
487214003656	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
487214003657	dsRNA binding site [nucleotide binding]; other site
487214003658	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
487214003659	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
487214003660	active site
487214003661	McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268
487214003662	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
487214003663	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214003664	Walker A motif; other site
487214003665	ATP binding site [chemical binding]; other site
487214003666	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
487214003667	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
487214003668	substrate binding site [chemical binding]; other site
487214003669	Predicted membrane protein [Function unknown]; Region: COG3326
487214003670	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
487214003671	tartrate dehydrogenase; Region: TTC; TIGR02089
487214003672	2-isopropylmalate synthase; Validated; Region: PRK00915
487214003673	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
487214003674	metal binding site [ion binding]; metal-binding site
487214003675	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
487214003676	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
487214003677	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
487214003678	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
487214003679	DNA topoisomerase I; Validated; Region: PRK05582
487214003680	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
487214003681	active site
487214003682	interdomain interaction site; other site
487214003683	putative metal-binding site [ion binding]; other site
487214003684	nucleotide binding site [chemical binding]; other site
487214003685	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
487214003686	domain I; other site
487214003687	DNA binding groove [nucleotide binding]
487214003688	phosphate binding site [ion binding]; other site
487214003689	domain II; other site
487214003690	domain III; other site
487214003691	nucleotide binding site [chemical binding]; other site
487214003692	catalytic site [active]
487214003693	domain IV; other site
487214003694	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
487214003695	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
487214003696	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
487214003697	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
487214003698	DNA protecting protein DprA; Region: dprA; TIGR00732
487214003699	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
487214003700	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
487214003701	active site
487214003702	metal-binding site
487214003703	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
487214003704	Phosphotransferase enzyme family; Region: APH; pfam01636
487214003705	active site
487214003706	substrate binding site [chemical binding]; other site
487214003707	ATP binding site [chemical binding]; other site
487214003708	dimer interface [polypeptide binding]; other site
487214003709	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
487214003710	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
487214003711	putative NAD(P) binding site [chemical binding]; other site
487214003712	putative catalytic Zn binding site [ion binding]; other site
487214003713	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
487214003714	substrate binding site; other site
487214003715	dimer interface; other site
487214003716	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
487214003717	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
487214003718	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
487214003719	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
487214003720	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
487214003721	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
487214003722	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
487214003723	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
487214003724	ATP-grasp domain; Region: ATP-grasp_4; cl17255
487214003725	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
487214003726	IMP binding site; other site
487214003727	dimer interface [polypeptide binding]; other site
487214003728	interdomain contacts; other site
487214003729	partial ornithine binding site; other site
487214003730	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
487214003731	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
487214003732	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
487214003733	catalytic site [active]
487214003734	subunit interface [polypeptide binding]; other site
487214003735	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
487214003736	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
487214003737	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
487214003738	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
487214003739	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487214003740	active site
487214003741	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
487214003742	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
487214003743	minor groove reading motif; other site
487214003744	helix-hairpin-helix signature motif; other site
487214003745	substrate binding pocket [chemical binding]; other site
487214003746	active site
487214003747	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
487214003748	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
487214003749	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487214003750	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487214003751	heat shock protein HtpX; Provisional; Region: PRK04897
487214003752	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
487214003753	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
487214003754	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214003755	S-adenosylmethionine binding site [chemical binding]; other site
487214003756	DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920
487214003757	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
487214003758	Int/Topo IB signature motif; other site
487214003759	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
487214003760	Helix-turn-helix domain; Region: HTH_16; pfam12645
487214003761	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
487214003762	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
487214003763	DNA binding residues [nucleotide binding]
487214003764	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214003765	non-specific DNA binding site [nucleotide binding]; other site
487214003766	salt bridge; other site
487214003767	sequence-specific DNA binding site [nucleotide binding]; other site
487214003768	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
487214003769	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
487214003770	G1 box; other site
487214003771	putative GEF interaction site [polypeptide binding]; other site
487214003772	GTP/Mg2+ binding site [chemical binding]; other site
487214003773	Switch I region; other site
487214003774	G2 box; other site
487214003775	G3 box; other site
487214003776	Switch II region; other site
487214003777	G4 box; other site
487214003778	G5 box; other site
487214003779	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
487214003780	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
487214003781	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
487214003782	tetracycline resistance determinant leader peptide; Provisional; Region: PRK14751
487214003783	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
487214003784	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
487214003785	N-acetyl-D-glucosamine binding site [chemical binding]; other site
487214003786	catalytic residue [active]
487214003787	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
487214003788	NlpC/P60 family; Region: NLPC_P60; pfam00877
487214003789	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
487214003790	Haemolysin-III related; Region: HlyIII; cl03831
487214003791	AAA-like domain; Region: AAA_10; pfam12846
487214003792	TcpE family; Region: TcpE; pfam12648
487214003793	Antirestriction protein (ArdA); Region: ArdA; pfam07275
487214003794	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
487214003795	Transposase; Region: DDE_Tnp_ISL3; pfam01610
487214003796	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
487214003797	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214003798	S-adenosylmethionine binding site [chemical binding]; other site
487214003799	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214003800	non-specific DNA binding site [nucleotide binding]; other site
487214003801	salt bridge; other site
487214003802	sequence-specific DNA binding site [nucleotide binding]; other site
487214003803	Replication initiation factor; Region: Rep_trans; pfam02486
487214003804	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
487214003805	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214003806	Walker A motif; other site
487214003807	ATP binding site [chemical binding]; other site
487214003808	Walker B motif; other site
487214003809	arginine finger; other site
487214003810	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
487214003811	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
487214003812	uracil transporter; Provisional; Region: PRK10720
487214003813	signal recognition particle protein; Provisional; Region: PRK10867
487214003814	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
487214003815	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
487214003816	P loop; other site
487214003817	GTP binding site [chemical binding]; other site
487214003818	Signal peptide binding domain; Region: SRP_SPB; pfam02978
487214003819	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
487214003820	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
487214003821	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
487214003822	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
487214003823	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
487214003824	Zn2+ binding site [ion binding]; other site
487214003825	Mg2+ binding site [ion binding]; other site
487214003826	sugar phosphate phosphatase; Provisional; Region: PRK10513
487214003827	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214003828	active site
487214003829	motif I; other site
487214003830	motif II; other site
487214003831	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214003832	SAP domain; Region: SAP; pfam02037
487214003833	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
487214003834	camphor resistance protein CrcB; Provisional; Region: PRK14229
487214003835	camphor resistance protein CrcB; Provisional; Region: PRK14221
487214003836	hypothetical protein; Provisional; Region: PRK07248
487214003837	flavodoxin; Validated; Region: PRK07308
487214003838	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
487214003839	DHH family; Region: DHH; pfam01368
487214003840	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
487214003841	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
487214003842	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
487214003843	Winged helix-turn helix; Region: HTH_33; pfam13592
487214003844	glutamate dehydrogenase; Provisional; Region: PRK09414
487214003845	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
487214003846	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
487214003847	NAD(P) binding site [chemical binding]; other site
487214003848	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214003849	Winged helix-turn helix; Region: HTH_29; pfam13551
487214003850	Homeodomain-like domain; Region: HTH_23; pfam13384
487214003851	DDE superfamily endonuclease; Region: DDE_3; pfam13358
487214003852	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
487214003853	Helix-turn-helix domain; Region: HTH_28; pfam13518
487214003854	putative transposase OrfB; Reviewed; Region: PHA02517
487214003855	HTH-like domain; Region: HTH_21; pfam13276
487214003856	Integrase core domain; Region: rve; pfam00665
487214003857	Integrase core domain; Region: rve_2; pfam13333
487214003858	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
487214003859	V-type ATP synthase subunit B; Provisional; Region: PRK04196
487214003860	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
487214003861	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
487214003862	Walker A motif homologous position; other site
487214003863	Walker B motif; other site
487214003864	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
487214003865	V-type ATP synthase subunit A; Provisional; Region: PRK04192
487214003866	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
487214003867	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
487214003868	Walker A motif/ATP binding site; other site
487214003869	Walker B motif; other site
487214003870	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
487214003871	V-type ATP synthase subunit F; Provisional; Region: PRK01395
487214003872	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
487214003873	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
487214003874	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
487214003875	V-type ATP synthase subunit K; Validated; Region: PRK06558
487214003876	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
487214003877	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
487214003878	V-type ATP synthase subunit I; Validated; Region: PRK05771
487214003879	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487214003880	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
487214003881	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
487214003882	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
487214003883	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
487214003884	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
487214003885	Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409
487214003886	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
487214003887	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
487214003888	Asp-box motif; other site
487214003889	catalytic site [active]
487214003890	Domain of unknown function (DUF386); Region: DUF386; pfam04074
487214003891	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
487214003892	Na binding site [ion binding]; other site
487214003893	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
487214003894	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
487214003895	inhibitor site; inhibition site
487214003896	active site
487214003897	dimer interface [polypeptide binding]; other site
487214003898	catalytic residue [active]
487214003899	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
487214003900	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
487214003901	putative active site cavity [active]
487214003902	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
487214003903	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
487214003904	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
487214003905	putative active site [active]
487214003906	CAAX protease self-immunity; Region: Abi; pfam02517
487214003907	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
487214003908	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
487214003909	Walker A/P-loop; other site
487214003910	ATP binding site [chemical binding]; other site
487214003911	Q-loop/lid; other site
487214003912	ABC transporter signature motif; other site
487214003913	Walker B; other site
487214003914	D-loop; other site
487214003915	H-loop/switch region; other site
487214003916	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
487214003917	Walker A/P-loop; other site
487214003918	ATP binding site [chemical binding]; other site
487214003919	ABC transporter; Region: ABC_tran; pfam00005
487214003920	Q-loop/lid; other site
487214003921	ABC transporter signature motif; other site
487214003922	Walker B; other site
487214003923	D-loop; other site
487214003924	H-loop/switch region; other site
487214003925	CAAX protease self-immunity; Region: Abi; pfam02517
487214003926	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
487214003927	Transposase; Region: DDE_Tnp_ISL3; pfam01610
487214003928	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
487214003929	core dimer interface [polypeptide binding]; other site
487214003930	L10 interface [polypeptide binding]; other site
487214003931	L11 interface [polypeptide binding]; other site
487214003932	putative EF-Tu interaction site [polypeptide binding]; other site
487214003933	putative EF-G interaction site [polypeptide binding]; other site
487214003934	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
487214003935	23S rRNA interface [nucleotide binding]; other site
487214003936	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
487214003937	chlorohydrolase; Validated; Region: PRK06687
487214003938	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
487214003939	active site
487214003940	putative substrate binding pocket [chemical binding]; other site
487214003941	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
487214003942	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
487214003943	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
487214003944	Walker A/P-loop; other site
487214003945	ATP binding site [chemical binding]; other site
487214003946	Q-loop/lid; other site
487214003947	ABC transporter signature motif; other site
487214003948	Walker B; other site
487214003949	D-loop; other site
487214003950	H-loop/switch region; other site
487214003951	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
487214003952	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
487214003953	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214003954	Walker A/P-loop; other site
487214003955	ATP binding site [chemical binding]; other site
487214003956	Q-loop/lid; other site
487214003957	ABC transporter signature motif; other site
487214003958	Walker B; other site
487214003959	D-loop; other site
487214003960	H-loop/switch region; other site
487214003961	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
487214003962	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
487214003963	SelR domain; Region: SelR; pfam01641
487214003964	homoserine kinase; Provisional; Region: PRK01212
487214003965	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
487214003966	homoserine dehydrogenase; Provisional; Region: PRK06349
487214003967	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
487214003968	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
487214003969	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
487214003970	adaptor protein; Provisional; Region: PRK02315
487214003971	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
487214003972	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
487214003973	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
487214003974	active site
487214003975	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
487214003976	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
487214003977	putative ADP-binding pocket [chemical binding]; other site
487214003978	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
487214003979	Transcriptional regulator [Transcription]; Region: LytR; COG1316
487214003980	prephenate dehydratase; Provisional; Region: PRK11898
487214003981	Prephenate dehydratase; Region: PDT; pfam00800
487214003982	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
487214003983	putative L-Phe binding site [chemical binding]; other site
487214003984	shikimate kinase; Reviewed; Region: aroK; PRK00131
487214003985	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
487214003986	ADP binding site [chemical binding]; other site
487214003987	magnesium binding site [ion binding]; other site
487214003988	putative shikimate binding site; other site
487214003989	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
487214003990	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
487214003991	hinge; other site
487214003992	active site
487214003993	hypothetical protein; Provisional; Region: PRK13676
487214003994	prephenate dehydrogenase; Validated; Region: PRK06545
487214003995	prephenate dehydrogenase; Validated; Region: PRK08507
487214003996	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
487214003997	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
487214003998	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
487214003999	Tetramer interface [polypeptide binding]; other site
487214004000	active site
487214004001	FMN-binding site [chemical binding]; other site
487214004002	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
487214004003	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
487214004004	active site
487214004005	dimer interface [polypeptide binding]; other site
487214004006	metal binding site [ion binding]; metal-binding site
487214004007	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
487214004008	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
487214004009	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
487214004010	shikimate binding site; other site
487214004011	NAD(P) binding site [chemical binding]; other site
487214004012	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
487214004013	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
487214004014	active site
487214004015	catalytic residue [active]
487214004016	dimer interface [polypeptide binding]; other site
487214004017	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
487214004018	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
487214004019	putative RNA binding site [nucleotide binding]; other site
487214004020	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214004021	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
487214004022	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
487214004023	Walker A/P-loop; other site
487214004024	ATP binding site [chemical binding]; other site
487214004025	Q-loop/lid; other site
487214004026	ABC transporter signature motif; other site
487214004027	Walker B; other site
487214004028	D-loop; other site
487214004029	H-loop/switch region; other site
487214004030	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
487214004031	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
487214004032	active site
487214004033	Na/Ca binding site [ion binding]; other site
487214004034	catalytic site [active]
487214004035	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
487214004036	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
487214004037	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
487214004038	motif 1; other site
487214004039	active site
487214004040	motif 2; other site
487214004041	motif 3; other site
487214004042	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
487214004043	DHHA1 domain; Region: DHHA1; pfam02272
487214004044	Uncharacterized conserved protein [Function unknown]; Region: COG4894
487214004045	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
487214004046	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
487214004047	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
487214004048	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214004049	dimer interface [polypeptide binding]; other site
487214004050	conserved gate region; other site
487214004051	putative PBP binding loops; other site
487214004052	ABC-ATPase subunit interface; other site
487214004053	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214004054	dimer interface [polypeptide binding]; other site
487214004055	conserved gate region; other site
487214004056	putative PBP binding loops; other site
487214004057	ABC-ATPase subunit interface; other site
487214004058	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
487214004059	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
487214004060	Walker A/P-loop; other site
487214004061	ATP binding site [chemical binding]; other site
487214004062	Q-loop/lid; other site
487214004063	ABC transporter signature motif; other site
487214004064	Walker B; other site
487214004065	D-loop; other site
487214004066	H-loop/switch region; other site
487214004067	TOBE domain; Region: TOBE_2; pfam08402
487214004068	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
487214004069	FAD binding domain; Region: FAD_binding_4; pfam01565
487214004070	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
487214004071	Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810
487214004072	Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810
487214004073	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
487214004074	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
487214004075	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487214004076	DNA-binding site [nucleotide binding]; DNA binding site
487214004077	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487214004078	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487214004079	homodimer interface [polypeptide binding]; other site
487214004080	catalytic residue [active]
487214004081	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
487214004082	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
487214004083	substrate binding pocket [chemical binding]; other site
487214004084	membrane-bound complex binding site; other site
487214004085	hinge residues; other site
487214004086	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
487214004087	PhoU domain; Region: PhoU; pfam01895
487214004088	PhoU domain; Region: PhoU; pfam01895
487214004089	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
487214004090	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
487214004091	Walker A/P-loop; other site
487214004092	ATP binding site [chemical binding]; other site
487214004093	Q-loop/lid; other site
487214004094	ABC transporter signature motif; other site
487214004095	Walker B; other site
487214004096	D-loop; other site
487214004097	H-loop/switch region; other site
487214004098	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
487214004099	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
487214004100	Walker A/P-loop; other site
487214004101	ATP binding site [chemical binding]; other site
487214004102	Q-loop/lid; other site
487214004103	ABC transporter signature motif; other site
487214004104	Walker B; other site
487214004105	D-loop; other site
487214004106	H-loop/switch region; other site
487214004107	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
487214004108	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214004109	dimer interface [polypeptide binding]; other site
487214004110	conserved gate region; other site
487214004111	putative PBP binding loops; other site
487214004112	ABC-ATPase subunit interface; other site
487214004113	sulfate transport protein; Provisional; Region: cysT; CHL00187
487214004114	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214004115	dimer interface [polypeptide binding]; other site
487214004116	conserved gate region; other site
487214004117	putative PBP binding loops; other site
487214004118	ABC-ATPase subunit interface; other site
487214004119	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
487214004120	phosphate binding protein; Region: ptsS_2; TIGR02136
487214004121	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
487214004122	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214004123	S-adenosylmethionine binding site [chemical binding]; other site
487214004124	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
487214004125	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
487214004126	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
487214004127	active site
487214004128	hypothetical protein; Provisional; Region: PRK04387
487214004129	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
487214004130	ArsC family; Region: ArsC; pfam03960
487214004131	putative catalytic residues [active]
487214004132	thiol/disulfide switch; other site
487214004133	Predicted membrane protein [Function unknown]; Region: COG4478
487214004134	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
487214004135	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214004136	active site
487214004137	motif I; other site
487214004138	motif II; other site
487214004139	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214004140	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
487214004141	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
487214004142	active site
487214004143	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
487214004144	active site
487214004145	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
487214004146	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
487214004147	FeS/SAM binding site; other site
487214004148	HemN C-terminal domain; Region: HemN_C; pfam06969
487214004149	YtxH-like protein; Region: YtxH; pfam12732
487214004150	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
487214004151	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
487214004152	HPr kinase/phosphorylase; Provisional; Region: PRK05428
487214004153	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
487214004154	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
487214004155	Hpr binding site; other site
487214004156	active site
487214004157	homohexamer subunit interaction site [polypeptide binding]; other site
487214004158	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
487214004159	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
487214004160	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
487214004161	active site
487214004162	trimer interface [polypeptide binding]; other site
487214004163	allosteric site; other site
487214004164	active site lid [active]
487214004165	hexamer (dimer of trimers) interface [polypeptide binding]; other site
487214004166	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
487214004167	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
487214004168	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
487214004169	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214004170	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
487214004171	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
487214004172	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
487214004173	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
487214004174	homodimer interface [polypeptide binding]; other site
487214004175	NAD binding pocket [chemical binding]; other site
487214004176	ATP binding pocket [chemical binding]; other site
487214004177	Mg binding site [ion binding]; other site
487214004178	active-site loop [active]
487214004179	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
487214004180	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
487214004181	active site
487214004182	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214004183	non-specific DNA binding site [nucleotide binding]; other site
487214004184	salt bridge; other site
487214004185	sequence-specific DNA binding site [nucleotide binding]; other site
487214004186	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214004187	ABC transporter; Region: ABC_tran; pfam00005
487214004188	Q-loop/lid; other site
487214004189	ABC transporter signature motif; other site
487214004190	Walker B; other site
487214004191	D-loop; other site
487214004192	H-loop/switch region; other site
487214004193	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
487214004194	Peptidase family U32; Region: Peptidase_U32; pfam01136
487214004195	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
487214004196	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
487214004197	Peptidase family U32; Region: Peptidase_U32; pfam01136
487214004198	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
487214004199	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214004200	S-adenosylmethionine binding site [chemical binding]; other site
487214004201	GMP synthase; Reviewed; Region: guaA; PRK00074
487214004202	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
487214004203	AMP/PPi binding site [chemical binding]; other site
487214004204	candidate oxyanion hole; other site
487214004205	catalytic triad [active]
487214004206	potential glutamine specificity residues [chemical binding]; other site
487214004207	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
487214004208	ATP Binding subdomain [chemical binding]; other site
487214004209	Dimerization subdomain; other site
487214004210	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
487214004211	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487214004212	DNA-binding site [nucleotide binding]; DNA binding site
487214004213	UTRA domain; Region: UTRA; pfam07702
487214004214	EamA-like transporter family; Region: EamA; pfam00892
487214004215	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
487214004216	Beta-lactamase; Region: Beta-lactamase; pfam00144
487214004217	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
487214004218	active site
487214004219	catalytic triad [active]
487214004220	oxyanion hole [active]
487214004221	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
487214004222	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214004223	active site
487214004224	motif I; other site
487214004225	motif II; other site
487214004226	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214004227	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
487214004228	active site
487214004229	catalytic residues [active]
487214004230	metal binding site [ion binding]; metal-binding site
487214004231	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
487214004232	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
487214004233	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
487214004234	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
487214004235	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487214004236	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487214004237	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
487214004238	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
487214004239	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
487214004240	Walker A/P-loop; other site
487214004241	ATP binding site [chemical binding]; other site
487214004242	Q-loop/lid; other site
487214004243	ABC transporter signature motif; other site
487214004244	Walker B; other site
487214004245	D-loop; other site
487214004246	H-loop/switch region; other site
487214004247	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
487214004248	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214004249	ABC-ATPase subunit interface; other site
487214004250	putative PBP binding loops; other site
487214004251	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
487214004252	putative ArsC-like catalytic residues; other site
487214004253	putative TRX-like catalytic residues [active]
487214004254	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
487214004255	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
487214004256	DNA binding site [nucleotide binding]
487214004257	active site
487214004258	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
487214004259	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
487214004260	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
487214004261	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
487214004262	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
487214004263	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
487214004264	predicted active site [active]
487214004265	catalytic triad [active]
487214004266	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
487214004267	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
487214004268	active site
487214004269	multimer interface [polypeptide binding]; other site
487214004270	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
487214004271	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487214004272	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
487214004273	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
487214004274	ApbE family; Region: ApbE; pfam02424
487214004275	Predicted flavoprotein [General function prediction only]; Region: COG0431
487214004276	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
487214004277	Predicted flavoprotein [General function prediction only]; Region: COG0431
487214004278	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
487214004279	PAS domain; Region: PAS_10; pfam13596
487214004280	hypothetical protein; Provisional; Region: PRK02539
487214004281	Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751
487214004282	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
487214004283	DALR anticodon binding domain; Region: DALR_1; pfam05746
487214004284	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
487214004285	dimer interface [polypeptide binding]; other site
487214004286	motif 1; other site
487214004287	active site
487214004288	motif 2; other site
487214004289	motif 3; other site
487214004290	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
487214004291	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
487214004292	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
487214004293	active site
487214004294	catalytic tetrad [active]
487214004295	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
487214004296	Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947
487214004297	NodB motif; other site
487214004298	active site
487214004299	catalytic site [active]
487214004300	Zn binding site [ion binding]; other site
487214004301	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
487214004302	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
487214004303	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
487214004304	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
487214004305	DEAD-like helicases superfamily; Region: DEXDc; smart00487
487214004306	ATP binding site [chemical binding]; other site
487214004307	putative Mg++ binding site [ion binding]; other site
487214004308	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487214004309	nucleotide binding region [chemical binding]; other site
487214004310	ATP-binding site [chemical binding]; other site
487214004311	DDE superfamily endonuclease; Region: DDE_3; pfam13358
487214004312	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
487214004313	elongation factor Tu; Reviewed; Region: PRK00049
487214004314	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
487214004315	G1 box; other site
487214004316	GEF interaction site [polypeptide binding]; other site
487214004317	GTP/Mg2+ binding site [chemical binding]; other site
487214004318	Switch I region; other site
487214004319	G2 box; other site
487214004320	G3 box; other site
487214004321	Switch II region; other site
487214004322	G4 box; other site
487214004323	G5 box; other site
487214004324	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
487214004325	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
487214004326	Antibiotic Binding Site [chemical binding]; other site
487214004327	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
487214004328	amphipathic channel; other site
487214004329	Asn-Pro-Ala signature motifs; other site
487214004330	MucBP domain; Region: MucBP; pfam06458
487214004331	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
487214004332	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
487214004333	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
487214004334	active site
487214004335	substrate binding site [chemical binding]; other site
487214004336	metal binding site [ion binding]; metal-binding site
487214004337	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
487214004338	catalytic residues [active]
487214004339	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
487214004340	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
487214004341	substrate binding pocket [chemical binding]; other site
487214004342	membrane-bound complex binding site; other site
487214004343	hinge residues; other site
487214004344	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
487214004345	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214004346	Walker A/P-loop; other site
487214004347	ATP binding site [chemical binding]; other site
487214004348	Q-loop/lid; other site
487214004349	ABC transporter signature motif; other site
487214004350	Walker B; other site
487214004351	D-loop; other site
487214004352	H-loop/switch region; other site
487214004353	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214004354	dimer interface [polypeptide binding]; other site
487214004355	conserved gate region; other site
487214004356	putative PBP binding loops; other site
487214004357	ABC-ATPase subunit interface; other site
487214004358	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
487214004359	TPR motif; other site
487214004360	binding surface
487214004361	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
487214004362	binding surface
487214004363	TPR motif; other site
487214004364	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
487214004365	Domain of unknown function DUF20; Region: UPF0118; pfam01594
487214004366	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
487214004367	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
487214004368	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
487214004369	gamma subunit interface [polypeptide binding]; other site
487214004370	epsilon subunit interface [polypeptide binding]; other site
487214004371	LBP interface [polypeptide binding]; other site
487214004372	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
487214004373	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
487214004374	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
487214004375	alpha subunit interaction interface [polypeptide binding]; other site
487214004376	Walker A motif; other site
487214004377	ATP binding site [chemical binding]; other site
487214004378	Walker B motif; other site
487214004379	inhibitor binding site; inhibition site
487214004380	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
487214004381	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
487214004382	core domain interface [polypeptide binding]; other site
487214004383	delta subunit interface [polypeptide binding]; other site
487214004384	epsilon subunit interface [polypeptide binding]; other site
487214004385	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
487214004386	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
487214004387	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
487214004388	beta subunit interaction interface [polypeptide binding]; other site
487214004389	Walker A motif; other site
487214004390	ATP binding site [chemical binding]; other site
487214004391	Walker B motif; other site
487214004392	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
487214004393	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
487214004394	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
487214004395	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
487214004396	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
487214004397	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
487214004398	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
487214004399	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
487214004400	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
487214004401	Helix-turn-helix domain; Region: HTH_38; pfam13936
487214004402	Integrase core domain; Region: rve; pfam00665
487214004403	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487214004404	Coenzyme A binding pocket [chemical binding]; other site
487214004405	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
487214004406	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
487214004407	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
487214004408	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
487214004409	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
487214004410	dimerization interface [polypeptide binding]; other site
487214004411	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
487214004412	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487214004413	Coenzyme A binding pocket [chemical binding]; other site
487214004414	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487214004415	Coenzyme A binding pocket [chemical binding]; other site
487214004416	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
487214004417	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
487214004418	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
487214004419	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
487214004420	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
487214004421	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
487214004422	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487214004423	ATP binding site [chemical binding]; other site
487214004424	putative Mg++ binding site [ion binding]; other site
487214004425	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487214004426	nucleotide binding region [chemical binding]; other site
487214004427	ATP-binding site [chemical binding]; other site
487214004428	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
487214004429	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487214004430	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487214004431	homodimer interface [polypeptide binding]; other site
487214004432	catalytic residue [active]
487214004433	cystathionine gamma-synthase; Reviewed; Region: PRK07269
487214004434	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
487214004435	homodimer interface [polypeptide binding]; other site
487214004436	substrate-cofactor binding pocket; other site
487214004437	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487214004438	catalytic residue [active]
487214004439	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
487214004440	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
487214004441	peptide binding site [polypeptide binding]; other site
487214004442	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
487214004443	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
487214004444	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
487214004445	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
487214004446	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
487214004447	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
487214004448	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
487214004449	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
487214004450	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
487214004451	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
487214004452	DHH family; Region: DHH; pfam01368
487214004453	DHHA2 domain; Region: DHHA2; pfam02833
487214004454	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
487214004455	GIY-YIG motif/motif A; other site
487214004456	putative active site [active]
487214004457	putative metal binding site [ion binding]; other site
487214004458	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
487214004459	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214004460	S-adenosylmethionine binding site [chemical binding]; other site
487214004461	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
487214004462	hypothetical protein; Provisional; Region: PRK07252
487214004463	RNA binding site [nucleotide binding]; other site
487214004464	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214004465	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
487214004466	active site
487214004467	motif I; other site
487214004468	motif II; other site
487214004469	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214004470	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
487214004471	active site
487214004472	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
487214004473	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
487214004474	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
487214004475	dimer interface [polypeptide binding]; other site
487214004476	ssDNA binding site [nucleotide binding]; other site
487214004477	tetramer (dimer of dimers) interface [polypeptide binding]; other site
487214004478	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
487214004479	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
487214004480	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
487214004481	putative dimer interface [polypeptide binding]; other site
487214004482	putative anticodon binding site; other site
487214004483	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
487214004484	homodimer interface [polypeptide binding]; other site
487214004485	motif 1; other site
487214004486	motif 2; other site
487214004487	active site
487214004488	motif 3; other site
487214004489	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
487214004490	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
487214004491	aspartate aminotransferase; Provisional; Region: PRK05764
487214004492	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487214004493	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487214004494	homodimer interface [polypeptide binding]; other site
487214004495	catalytic residue [active]
487214004496	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
487214004497	Predicted flavoprotein [General function prediction only]; Region: COG0431
487214004498	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
487214004499	hypothetical protein; Validated; Region: PRK02101
487214004500	Protein of unknown function (DUF3953); Region: DUF3953; pfam13129
487214004501	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
487214004502	active site
487214004503	catalytic residues [active]
487214004504	metal binding site [ion binding]; metal-binding site
487214004505	putative S-transferase; Provisional; Region: PRK11752
487214004506	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
487214004507	C-terminal domain interface [polypeptide binding]; other site
487214004508	GSH binding site (G-site) [chemical binding]; other site
487214004509	dimer interface [polypeptide binding]; other site
487214004510	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
487214004511	N-terminal domain interface [polypeptide binding]; other site
487214004512	dimer interface [polypeptide binding]; other site
487214004513	substrate binding pocket (H-site) [chemical binding]; other site
487214004514	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
487214004515	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
487214004516	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
487214004517	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
487214004518	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
487214004519	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
487214004520	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
487214004521	Cation efflux family; Region: Cation_efflux; pfam01545
487214004522	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
487214004523	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
487214004524	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214004525	Walker A/P-loop; other site
487214004526	ATP binding site [chemical binding]; other site
487214004527	Q-loop/lid; other site
487214004528	ABC transporter signature motif; other site
487214004529	Walker B; other site
487214004530	D-loop; other site
487214004531	H-loop/switch region; other site
487214004532	ABC transporter; Region: ABC_tran_2; pfam12848
487214004533	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487214004534	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
487214004535	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
487214004536	active site
487214004537	NTP binding site [chemical binding]; other site
487214004538	metal binding triad [ion binding]; metal-binding site
487214004539	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
487214004540	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
487214004541	dihydrodipicolinate reductase; Provisional; Region: PRK00048
487214004542	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
487214004543	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
487214004544	EDD domain protein, DegV family; Region: DegV; TIGR00762
487214004545	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
487214004546	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835
487214004547	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
487214004548	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
487214004549	active site
487214004550	substrate binding site [chemical binding]; other site
487214004551	metal binding site [ion binding]; metal-binding site
487214004552	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
487214004553	YbbR-like protein; Region: YbbR; pfam07949
487214004554	Uncharacterized conserved protein [Function unknown]; Region: COG1624
487214004555	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
487214004556	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
487214004557	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
487214004558	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487214004559	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
487214004560	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
487214004561	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
487214004562	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
487214004563	dimer interface [polypeptide binding]; other site
487214004564	phosphate binding site [ion binding]; other site
487214004565	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
487214004566	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
487214004567	homotrimer interaction site [polypeptide binding]; other site
487214004568	putative active site [active]
487214004569	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
487214004570	G1 box; other site
487214004571	GTP/Mg2+ binding site [chemical binding]; other site
487214004572	Switch I region; other site
487214004573	G2 box; other site
487214004574	G3 box; other site
487214004575	Switch II region; other site
487214004576	G4 box; other site
487214004577	G5 box; other site
487214004578	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
487214004579	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
487214004580	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214004581	Walker A motif; other site
487214004582	ATP binding site [chemical binding]; other site
487214004583	Walker B motif; other site
487214004584	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
487214004585	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
487214004586	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
487214004587	folate binding site [chemical binding]; other site
487214004588	NADP+ binding site [chemical binding]; other site
487214004589	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
487214004590	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
487214004591	dimerization interface [polypeptide binding]; other site
487214004592	DPS ferroxidase diiron center [ion binding]; other site
487214004593	ion pore; other site
487214004594	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
487214004595	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
487214004596	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
487214004597	active site
487214004598	triosephosphate isomerase; Provisional; Region: PRK14567
487214004599	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
487214004600	substrate binding site [chemical binding]; other site
487214004601	dimer interface [polypeptide binding]; other site
487214004602	catalytic triad [active]
487214004603	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
487214004604	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
487214004605	Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897
487214004606	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
487214004607	proposed active site lysine [active]
487214004608	conserved cys residue [active]
487214004609	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487214004610	active site
487214004611	Methyltransferase domain; Region: Methyltransf_31; pfam13847
487214004612	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214004613	S-adenosylmethionine binding site [chemical binding]; other site
487214004614	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
487214004615	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
487214004616	Walker A/P-loop; other site
487214004617	ATP binding site [chemical binding]; other site
487214004618	Q-loop/lid; other site
487214004619	ABC transporter signature motif; other site
487214004620	Walker B; other site
487214004621	D-loop; other site
487214004622	H-loop/switch region; other site
487214004623	TOBE domain; Region: TOBE_2; pfam08402
487214004624	Isochorismatase family; Region: Isochorismatase; pfam00857
487214004625	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
487214004626	catalytic triad [active]
487214004627	conserved cis-peptide bond; other site
487214004628	Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465
487214004629	CodY GAF-like domain; Region: CodY; pfam06018
487214004630	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
487214004631	putative DNA binding site [nucleotide binding]; other site
487214004632	putative Zn2+ binding site [ion binding]; other site
487214004633	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
487214004634	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
487214004635	ATP binding site [chemical binding]; other site
487214004636	Mg++ binding site [ion binding]; other site
487214004637	motif III; other site
487214004638	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487214004639	nucleotide binding region [chemical binding]; other site
487214004640	ATP-binding site [chemical binding]; other site
487214004641	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
487214004642	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487214004643	putative substrate translocation pore; other site
487214004644	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
487214004645	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
487214004646	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
487214004647	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
487214004648	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
487214004649	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
487214004650	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
487214004651	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
487214004652	catalytic triad [active]
487214004653	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
487214004654	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
487214004655	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
487214004656	active site
487214004657	Predicted membrane protein [Function unknown]; Region: COG4720
487214004658	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
487214004659	dimer interface [polypeptide binding]; other site
487214004660	substrate binding site [chemical binding]; other site
487214004661	ATP binding site [chemical binding]; other site
487214004662	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
487214004663	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
487214004664	dimerization interface 3.5A [polypeptide binding]; other site
487214004665	active site
487214004666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487214004667	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
487214004668	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
487214004669	PhnA protein; Region: PhnA; pfam03831
487214004670	cytidylate kinase; Provisional; Region: cmk; PRK00023
487214004671	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
487214004672	CMP-binding site; other site
487214004673	The sites determining sugar specificity; other site
487214004674	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
487214004675	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
487214004676	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
487214004677	Ligand binding site; other site
487214004678	Putative Catalytic site; other site
487214004679	DXD motif; other site
487214004680	UDP-glucose 4-epimerase; Region: PLN02240
487214004681	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
487214004682	NAD binding site [chemical binding]; other site
487214004683	homodimer interface [polypeptide binding]; other site
487214004684	active site
487214004685	substrate binding site [chemical binding]; other site
487214004686	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
487214004687	Uncharacterized conserved protein [Function unknown]; Region: COG0327
487214004688	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
487214004689	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
487214004690	Family of unknown function (DUF633); Region: DUF633; pfam04816
487214004691	putative transposase OrfB; Reviewed; Region: PHA02517
487214004692	HTH-like domain; Region: HTH_21; pfam13276
487214004693	Integrase core domain; Region: rve; pfam00665
487214004694	Integrase core domain; Region: rve_2; pfam13333
487214004695	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
487214004696	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
487214004697	TPP-binding site [chemical binding]; other site
487214004698	dimer interface [polypeptide binding]; other site
487214004699	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
487214004700	PYR/PP interface [polypeptide binding]; other site
487214004701	dimer interface [polypeptide binding]; other site
487214004702	TPP binding site [chemical binding]; other site
487214004703	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
487214004704	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
487214004705	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
487214004706	substrate binding site [chemical binding]; other site
487214004707	hexamer interface [polypeptide binding]; other site
487214004708	metal binding site [ion binding]; metal-binding site
487214004709	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
487214004710	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
487214004711	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
487214004712	active site
487214004713	phosphorylation site [posttranslational modification]
487214004714	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
487214004715	active site
487214004716	phosphorylation site [posttranslational modification]
487214004717	HTH domain; Region: HTH_11; pfam08279
487214004718	Mga helix-turn-helix domain; Region: Mga; pfam05043
487214004719	PRD domain; Region: PRD; pfam00874
487214004720	PRD domain; Region: PRD; pfam00874
487214004721	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
487214004722	active site
487214004723	P-loop; other site
487214004724	phosphorylation site [posttranslational modification]
487214004725	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
487214004726	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
487214004727	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
487214004728	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214004729	motif II; other site
487214004730	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
487214004731	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
487214004732	putative acyl-acceptor binding pocket; other site
487214004733	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
487214004734	Cadmium resistance transporter; Region: Cad; pfam03596
487214004735	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
487214004736	16S/18S rRNA binding site [nucleotide binding]; other site
487214004737	S13e-L30e interaction site [polypeptide binding]; other site
487214004738	25S rRNA binding site [nucleotide binding]; other site
487214004739	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
487214004740	NADH(P)-binding; Region: NAD_binding_10; pfam13460
487214004741	NAD binding site [chemical binding]; other site
487214004742	substrate binding site [chemical binding]; other site
487214004743	putative active site [active]
487214004744	T-box leader
487214004745	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
487214004746	metal binding site [ion binding]; metal-binding site
487214004747	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
487214004748	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
487214004749	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
487214004750	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
487214004751	active site
487214004752	dimer interface [polypeptide binding]; other site
487214004753	motif 1; other site
487214004754	motif 2; other site
487214004755	motif 3; other site
487214004756	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
487214004757	anticodon binding site; other site
487214004758	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487214004759	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214004760	ATP binding site [chemical binding]; other site
487214004761	Mg2+ binding site [ion binding]; other site
487214004762	G-X-G motif; other site
487214004763	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487214004764	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487214004765	active site
487214004766	phosphorylation site [posttranslational modification]
487214004767	intermolecular recognition site; other site
487214004768	dimerization interface [polypeptide binding]; other site
487214004769	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487214004770	DNA binding site [nucleotide binding]
487214004771	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
487214004772	nucleophilic elbow; other site
487214004773	catalytic triad; other site
487214004774	Predicted transcriptional regulator [Transcription]; Region: COG1959
487214004775	Transcriptional regulator; Region: Rrf2; pfam02082
487214004776	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
487214004777	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
487214004778	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
487214004779	FeoA domain; Region: FeoA; pfam04023
487214004780	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
487214004781	putative active site [active]
487214004782	dimerization interface [polypeptide binding]; other site
487214004783	putative tRNAtyr binding site [nucleotide binding]; other site
487214004784	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
487214004785	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
487214004786	Zn2+ binding site [ion binding]; other site
487214004787	Mg2+ binding site [ion binding]; other site
487214004788	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
487214004789	synthetase active site [active]
487214004790	NTP binding site [chemical binding]; other site
487214004791	metal binding site [ion binding]; metal-binding site
487214004792	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
487214004793	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
487214004794	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
487214004795	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
487214004796	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
487214004797	active site
487214004798	Zn binding site [ion binding]; other site
487214004799	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
487214004800	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
487214004801	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
487214004802	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
487214004803	ABC-ATPase subunit  interface; other site
487214004804	dimer interface [polypeptide binding]; other site
487214004805	putative PBP binding regions; other site
487214004806	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
487214004807	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
487214004808	metal binding site [ion binding]; metal-binding site
487214004809	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
487214004810	dimer interface [polypeptide binding]; other site
487214004811	catalytic triad [active]
487214004812	peroxidatic and resolving cysteines [active]
487214004813	FtsX-like permease family; Region: FtsX; pfam02687
487214004814	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
487214004815	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
487214004816	FtsX-like permease family; Region: FtsX; pfam02687
487214004817	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
487214004818	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
487214004819	Walker A/P-loop; other site
487214004820	ATP binding site [chemical binding]; other site
487214004821	Q-loop/lid; other site
487214004822	ABC transporter signature motif; other site
487214004823	Walker B; other site
487214004824	D-loop; other site
487214004825	H-loop/switch region; other site
487214004826	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487214004827	catalytic core [active]
487214004828	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
487214004829	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
487214004830	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
487214004831	active site
487214004832	HIGH motif; other site
487214004833	nucleotide binding site [chemical binding]; other site
487214004834	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
487214004835	active site
487214004836	KMSKS motif; other site
487214004837	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
487214004838	tRNA binding surface [nucleotide binding]; other site
487214004839	anticodon binding site; other site
487214004840	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
487214004841	T-box leader
487214004842	DivIVA domain; Region: DivI1A_domain; TIGR03544
487214004843	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
487214004844	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
487214004845	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
487214004846	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
487214004847	RNA binding surface [nucleotide binding]; other site
487214004848	YGGT family; Region: YGGT; pfam02325
487214004849	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
487214004850	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
487214004851	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
487214004852	catalytic residue [active]
487214004853	cell division protein FtsZ; Validated; Region: PRK09330
487214004854	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
487214004855	nucleotide binding site [chemical binding]; other site
487214004856	SulA interaction site; other site
487214004857	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
487214004858	Cell division protein FtsA; Region: FtsA; smart00842
487214004859	Cell division protein FtsA; Region: FtsA; pfam14450
487214004860	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
487214004861	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
487214004862	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
487214004863	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
487214004864	nudix motif; other site
487214004865	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
487214004866	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
487214004867	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
487214004868	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
487214004869	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
487214004870	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
487214004871	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
487214004872	recombination protein RecR; Reviewed; Region: recR; PRK00076
487214004873	RecR protein; Region: RecR; pfam02132
487214004874	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
487214004875	putative active site [active]
487214004876	putative metal-binding site [ion binding]; other site
487214004877	tetramer interface [polypeptide binding]; other site
487214004878	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
487214004879	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
487214004880	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
487214004881	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
487214004882	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
487214004883	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
487214004884	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
487214004885	putative active site [active]
487214004886	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
487214004887	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
487214004888	nucleotide binding site [chemical binding]; other site
487214004889	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
487214004890	Class I aldolases; Region: Aldolase_Class_I; cl17187
487214004891	catalytic residue [active]
487214004892	Protein of unknown function, DUF624; Region: DUF624; pfam04854
487214004893	Domain of unknown function (DUF386); Region: DUF386; pfam04074
487214004894	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
487214004895	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214004896	dimer interface [polypeptide binding]; other site
487214004897	conserved gate region; other site
487214004898	putative PBP binding loops; other site
487214004899	ABC-ATPase subunit interface; other site
487214004900	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
487214004901	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
487214004902	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214004903	putative PBP binding loops; other site
487214004904	dimer interface [polypeptide binding]; other site
487214004905	ABC-ATPase subunit interface; other site
487214004906	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
487214004907	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
487214004908	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
487214004909	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
487214004910	putative active site cavity [active]
487214004911	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
487214004912	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
487214004913	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
487214004914	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
487214004915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214004916	dimer interface [polypeptide binding]; other site
487214004917	conserved gate region; other site
487214004918	putative PBP binding loops; other site
487214004919	ABC-ATPase subunit interface; other site
487214004920	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
487214004921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214004922	dimer interface [polypeptide binding]; other site
487214004923	conserved gate region; other site
487214004924	putative PBP binding loops; other site
487214004925	ABC-ATPase subunit interface; other site
487214004926	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
487214004927	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
487214004928	uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022
487214004929	Sialidase, N-terminal domain; Region: Sialidase; pfam02973
487214004930	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
487214004931	catalytic site [active]
487214004932	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
487214004933	Asp-box motif; other site
487214004934	Asp-box motif; other site
487214004935	catalytic site [active]
487214004936	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
487214004937	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
487214004938	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
487214004939	ssDNA binding site; other site
487214004940	generic binding surface II; other site
487214004941	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487214004942	ATP binding site [chemical binding]; other site
487214004943	putative Mg++ binding site [ion binding]; other site
487214004944	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487214004945	nucleotide binding region [chemical binding]; other site
487214004946	ATP-binding site [chemical binding]; other site
487214004947	alanine racemase; Reviewed; Region: alr; PRK00053
487214004948	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
487214004949	active site
487214004950	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
487214004951	dimer interface [polypeptide binding]; other site
487214004952	substrate binding site [chemical binding]; other site
487214004953	catalytic residues [active]
487214004954	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
487214004955	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
487214004956	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
487214004957	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
487214004958	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
487214004959	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
487214004960	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
487214004961	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487214004962	nucleotide binding region [chemical binding]; other site
487214004963	ATP-binding site [chemical binding]; other site
487214004964	SEC-C motif; Region: SEC-C; pfam02810
487214004965	protein-export membrane protein SecD; Region: secD; TIGR01129
487214004966	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
487214004967	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
487214004968	Walker A/P-loop; other site
487214004969	ATP binding site [chemical binding]; other site
487214004970	Q-loop/lid; other site
487214004971	ABC transporter signature motif; other site
487214004972	Walker B; other site
487214004973	D-loop; other site
487214004974	H-loop/switch region; other site
487214004975	GTP-binding protein Der; Reviewed; Region: PRK00093
487214004976	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
487214004977	G1 box; other site
487214004978	GTP/Mg2+ binding site [chemical binding]; other site
487214004979	Switch I region; other site
487214004980	G2 box; other site
487214004981	Switch II region; other site
487214004982	G3 box; other site
487214004983	G4 box; other site
487214004984	G5 box; other site
487214004985	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
487214004986	G1 box; other site
487214004987	GTP/Mg2+ binding site [chemical binding]; other site
487214004988	Switch I region; other site
487214004989	G2 box; other site
487214004990	G3 box; other site
487214004991	Switch II region; other site
487214004992	G4 box; other site
487214004993	G5 box; other site
487214004994	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
487214004995	dimer interface [polypeptide binding]; other site
487214004996	FMN binding site [chemical binding]; other site
487214004997	NADPH bind site [chemical binding]; other site
487214004998	primosomal protein DnaI; Reviewed; Region: PRK08939
487214004999	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
487214005000	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214005001	Walker A motif; other site
487214005002	ATP binding site [chemical binding]; other site
487214005003	Walker B motif; other site
487214005004	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
487214005005	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
487214005006	ATP cone domain; Region: ATP-cone; pfam03477
487214005007	Predicted transcriptional regulators [Transcription]; Region: COG1725
487214005008	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487214005009	DNA-binding site [nucleotide binding]; DNA binding site
487214005010	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
487214005011	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
487214005012	Walker A/P-loop; other site
487214005013	ATP binding site [chemical binding]; other site
487214005014	Q-loop/lid; other site
487214005015	ABC transporter signature motif; other site
487214005016	Walker B; other site
487214005017	D-loop; other site
487214005018	H-loop/switch region; other site
487214005019	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
487214005020	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
487214005021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214005022	Walker A/P-loop; other site
487214005023	ATP binding site [chemical binding]; other site
487214005024	Q-loop/lid; other site
487214005025	ABC transporter signature motif; other site
487214005026	Walker B; other site
487214005027	D-loop; other site
487214005028	H-loop/switch region; other site
487214005029	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
487214005030	Uncharacterized conserved protein [Function unknown]; Region: COG0398
487214005031	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
487214005032	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
487214005033	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
487214005034	nucleotide binding site [chemical binding]; other site
487214005035	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
487214005036	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
487214005037	active site turn [active]
487214005038	phosphorylation site [posttranslational modification]
487214005039	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
487214005040	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
487214005041	HPr interaction site; other site
487214005042	glycerol kinase (GK) interaction site [polypeptide binding]; other site
487214005043	active site
487214005044	phosphorylation site [posttranslational modification]
487214005045	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
487214005046	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
487214005047	substrate binding [chemical binding]; other site
487214005048	active site
487214005049	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
487214005050	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
487214005051	homodimer interface [polypeptide binding]; other site
487214005052	catalytic residues [active]
487214005053	NAD binding site [chemical binding]; other site
487214005054	substrate binding pocket [chemical binding]; other site
487214005055	flexible flap; other site
487214005056	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
487214005057	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
487214005058	dimer interface [polypeptide binding]; other site
487214005059	active site
487214005060	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
487214005061	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
487214005062	Uncharacterized conserved protein [Function unknown]; Region: COG3610
487214005063	Uncharacterized conserved protein [Function unknown]; Region: COG2966
487214005064	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
487214005065	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
487214005066	Catalytic domain of Protein Kinases; Region: PKc; cd00180
487214005067	active site
487214005068	ATP binding site [chemical binding]; other site
487214005069	substrate binding site [chemical binding]; other site
487214005070	activation loop (A-loop); other site
487214005071	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
487214005072	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
487214005073	PASTA domain; Region: PASTA; smart00740
487214005074	PASTA domain; Region: PASTA; smart00740
487214005075	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
487214005076	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
487214005077	active site
487214005078	16S rRNA methyltransferase B; Provisional; Region: PRK14902
487214005079	NusB family; Region: NusB; pfam01029
487214005080	putative RNA binding site [nucleotide binding]; other site
487214005081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214005082	S-adenosylmethionine binding site [chemical binding]; other site
487214005083	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
487214005084	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
487214005085	putative active site [active]
487214005086	substrate binding site [chemical binding]; other site
487214005087	putative cosubstrate binding site; other site
487214005088	catalytic site [active]
487214005089	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
487214005090	substrate binding site [chemical binding]; other site
487214005091	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
487214005092	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487214005093	ATP binding site [chemical binding]; other site
487214005094	putative Mg++ binding site [ion binding]; other site
487214005095	helicase superfamily c-terminal domain; Region: HELICc; smart00490
487214005096	ATP-binding site [chemical binding]; other site
487214005097	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
487214005098	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
487214005099	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
487214005100	catalytic site [active]
487214005101	G-X2-G-X-G-K; other site
487214005102	hypothetical protein; Provisional; Region: PRK00106
487214005103	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
487214005104	Zn2+ binding site [ion binding]; other site
487214005105	Mg2+ binding site [ion binding]; other site
487214005106	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
487214005107	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
487214005108	hypothetical protein; Provisional; Region: PRK13670
487214005109	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
487214005110	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
487214005111	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214005112	S-adenosylmethionine binding site [chemical binding]; other site
487214005113	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
487214005114	Isochorismatase family; Region: Isochorismatase; pfam00857
487214005115	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
487214005116	catalytic triad [active]
487214005117	conserved cis-peptide bond; other site
487214005118	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
487214005119	Zn2+ binding site [ion binding]; other site
487214005120	Mg2+ binding site [ion binding]; other site
487214005121	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
487214005122	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
487214005123	active site
487214005124	(T/H)XGH motif; other site
487214005125	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
487214005126	GTPase YqeH; Provisional; Region: PRK13796
487214005127	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
487214005128	GTP/Mg2+ binding site [chemical binding]; other site
487214005129	G4 box; other site
487214005130	G5 box; other site
487214005131	G1 box; other site
487214005132	Switch I region; other site
487214005133	G2 box; other site
487214005134	G3 box; other site
487214005135	Switch II region; other site
487214005136	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
487214005137	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214005138	active site
487214005139	motif I; other site
487214005140	motif II; other site
487214005141	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
487214005142	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
487214005143	Cl binding site [ion binding]; other site
487214005144	oligomer interface [polypeptide binding]; other site
487214005145	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
487214005146	Mechanosensitive ion channel; Region: MS_channel; pfam00924
487214005147	Predicted membrane protein [Function unknown]; Region: COG4129
487214005148	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
487214005149	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
487214005150	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
487214005151	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
487214005152	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
487214005153	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
487214005154	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
487214005155	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
487214005156	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
487214005157	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
487214005158	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
487214005159	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
487214005160	Adenylate cyclase associated (CAP) N terminal; Region: CAP_N; pfam01213
487214005161	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
487214005162	SecY translocase; Region: SecY; pfam00344
487214005163	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
487214005164	active site
487214005165	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
487214005166	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
487214005167	Ligand binding site; other site
487214005168	metal-binding site
487214005169	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
487214005170	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
487214005171	Ligand binding site; other site
487214005172	metal-binding site
487214005173	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
487214005174	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
487214005175	active site
487214005176	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
487214005177	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
487214005178	Ligand binding site; other site
487214005179	metal-binding site
487214005180	glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728
487214005181	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
487214005182	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
487214005183	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
487214005184	trimer interface [polypeptide binding]; other site
487214005185	active site
487214005186	substrate binding site [chemical binding]; other site
487214005187	CoA binding site [chemical binding]; other site
487214005188	serine-rich repeat adhesion glycoprotein AST domain; Region: ser_adhes_Nterm; TIGR04224
487214005189	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
487214005190	DDE superfamily endonuclease; Region: DDE_3; pfam13358
487214005191	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
487214005192	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
487214005193	catalytic residues [active]
487214005194	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
487214005195	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
487214005196	amphipathic channel; other site
487214005197	Asn-Pro-Ala signature motifs; other site
487214005198	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
487214005199	oligoendopeptidase F; Region: pepF; TIGR00181
487214005200	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
487214005201	Zn binding site [ion binding]; other site
487214005202	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
487214005203	RNA methyltransferase, RsmE family; Region: TIGR00046
487214005204	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
487214005205	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214005206	S-adenosylmethionine binding site [chemical binding]; other site
487214005207	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
487214005208	nudix motif; other site
487214005209	Peptidase family M50; Region: Peptidase_M50; pfam02163
487214005210	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
487214005211	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
487214005212	YcfA-like protein; Region: YcfA; pfam07927
487214005213	recombination factor protein RarA; Reviewed; Region: PRK13342
487214005214	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214005215	Walker A motif; other site
487214005216	ATP binding site [chemical binding]; other site
487214005217	Walker B motif; other site
487214005218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
487214005219	arginine finger; other site
487214005220	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
487214005221	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
487214005222	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
487214005223	substrate binding [chemical binding]; other site
487214005224	active site
487214005225	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
487214005226	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
487214005227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214005228	dimer interface [polypeptide binding]; other site
487214005229	conserved gate region; other site
487214005230	putative PBP binding loops; other site
487214005231	ABC-ATPase subunit interface; other site
487214005232	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
487214005233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214005234	dimer interface [polypeptide binding]; other site
487214005235	conserved gate region; other site
487214005236	putative PBP binding loops; other site
487214005237	ABC-ATPase subunit interface; other site
487214005238	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
487214005239	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
487214005240	Transcriptional regulators [Transcription]; Region: PurR; COG1609
487214005241	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
487214005242	DNA binding site [nucleotide binding]
487214005243	domain linker motif; other site
487214005244	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
487214005245	dimerization interface [polypeptide binding]; other site
487214005246	ligand binding site [chemical binding]; other site
487214005247	sodium binding site [ion binding]; other site
487214005248	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
487214005249	Mga helix-turn-helix domain; Region: Mga; pfam05043
487214005250	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
487214005251	Small integral membrane protein [Function unknown]; Region: COG5547
487214005252	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
487214005253	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
487214005254	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
487214005255	Uncharacterized conserved protein [Function unknown]; Region: COG1262
487214005256	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
487214005257	arylsulfatase; Provisional; Region: PRK13759
487214005258	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
487214005259	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
487214005260	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
487214005261	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
487214005262	active site
487214005263	methionine cluster; other site
487214005264	phosphorylation site [posttranslational modification]
487214005265	metal binding site [ion binding]; metal-binding site
487214005266	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
487214005267	active site
487214005268	P-loop; other site
487214005269	phosphorylation site [posttranslational modification]
487214005270	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
487214005271	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
487214005272	MarR family; Region: MarR_2; pfam12802
487214005273	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
487214005274	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
487214005275	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487214005276	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
487214005277	Coenzyme A binding pocket [chemical binding]; other site
487214005278	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
487214005279	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
487214005280	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
487214005281	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
487214005282	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
487214005283	substrate binding site [chemical binding]; other site
487214005284	active site
487214005285	catalytic residues [active]
487214005286	heterodimer interface [polypeptide binding]; other site
487214005287	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
487214005288	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
487214005289	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487214005290	catalytic residue [active]
487214005291	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
487214005292	active site
487214005293	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
487214005294	active site
487214005295	ribulose/triose binding site [chemical binding]; other site
487214005296	phosphate binding site [ion binding]; other site
487214005297	substrate (anthranilate) binding pocket [chemical binding]; other site
487214005298	product (indole) binding pocket [chemical binding]; other site
487214005299	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
487214005300	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
487214005301	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
487214005302	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
487214005303	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
487214005304	glutamine binding [chemical binding]; other site
487214005305	catalytic triad [active]
487214005306	anthranilate synthase component I; Provisional; Region: PRK13570
487214005307	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
487214005308	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
487214005309	T-box leader
487214005310	T-box leader
487214005311	Transcriptional regulators [Transcription]; Region: PurR; COG1609
487214005312	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
487214005313	DNA binding site [nucleotide binding]
487214005314	domain linker motif; other site
487214005315	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
487214005316	putative dimerization interface [polypeptide binding]; other site
487214005317	putative ligand binding site [chemical binding]; other site
487214005318	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
487214005319	MgtC family; Region: MgtC; pfam02308
487214005320	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
487214005321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214005322	dimer interface [polypeptide binding]; other site
487214005323	conserved gate region; other site
487214005324	putative PBP binding loops; other site
487214005325	ABC-ATPase subunit interface; other site
487214005326	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214005327	putative PBP binding loops; other site
487214005328	dimer interface [polypeptide binding]; other site
487214005329	ABC-ATPase subunit interface; other site
487214005330	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
487214005331	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214005332	Walker A/P-loop; other site
487214005333	ATP binding site [chemical binding]; other site
487214005334	Q-loop/lid; other site
487214005335	ABC transporter signature motif; other site
487214005336	Walker B; other site
487214005337	D-loop; other site
487214005338	H-loop/switch region; other site
487214005339	TOBE domain; Region: TOBE; pfam03459
487214005340	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
487214005341	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
487214005342	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255
487214005343	Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975
487214005344	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
487214005345	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
487214005346	Pectate lyase; Region: Pec_lyase_C; cl01593
487214005347	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
487214005348	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
487214005349	inhibitor-cofactor binding pocket; inhibition site
487214005350	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487214005351	catalytic residue [active]
487214005352	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
487214005353	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
487214005354	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
487214005355	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
487214005356	Walker A/P-loop; other site
487214005357	ATP binding site [chemical binding]; other site
487214005358	Q-loop/lid; other site
487214005359	ABC transporter signature motif; other site
487214005360	Walker B; other site
487214005361	D-loop; other site
487214005362	H-loop/switch region; other site
487214005363	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
487214005364	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
487214005365	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214005366	Walker A/P-loop; other site
487214005367	ATP binding site [chemical binding]; other site
487214005368	Q-loop/lid; other site
487214005369	ABC transporter signature motif; other site
487214005370	Walker B; other site
487214005371	D-loop; other site
487214005372	H-loop/switch region; other site
487214005373	Predicted membrane protein [Function unknown]; Region: COG2323
487214005374	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
487214005375	active site
487214005376	putative catalytic site [active]
487214005377	DNA binding site [nucleotide binding]
487214005378	putative phosphate binding site [ion binding]; other site
487214005379	metal binding site A [ion binding]; metal-binding site
487214005380	AP binding site [nucleotide binding]; other site
487214005381	metal binding site B [ion binding]; metal-binding site
487214005382	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487214005383	active site
487214005384	xanthine permease; Region: pbuX; TIGR03173
487214005385	Sulfate transporter family; Region: Sulfate_transp; pfam00916
487214005386	DpnII restriction endonuclease; Region: DpnII; pfam04556
487214005387	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
487214005388	DNA methylase; Region: N6_N4_Mtase; pfam01555
487214005389	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214005390	S-adenosylmethionine binding site [chemical binding]; other site
487214005391	DNA adenine methylase (dam); Region: dam; TIGR00571
487214005392	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
487214005393	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
487214005394	CoenzymeA binding site [chemical binding]; other site
487214005395	subunit interaction site [polypeptide binding]; other site
487214005396	PHB binding site; other site
487214005397	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
487214005398	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
487214005399	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
487214005400	galactokinase; Provisional; Region: PRK05322
487214005401	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
487214005402	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
487214005403	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
487214005404	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
487214005405	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
487214005406	DNA binding site [nucleotide binding]
487214005407	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
487214005408	putative dimerization interface [polypeptide binding]; other site
487214005409	putative ligand binding site [chemical binding]; other site
487214005410	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
487214005411	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
487214005412	catalytic Zn binding site [ion binding]; other site
487214005413	NAD(P) binding site [chemical binding]; other site
487214005414	structural Zn binding site [ion binding]; other site
487214005415	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
487214005416	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
487214005417	DNA binding residues [nucleotide binding]
487214005418	putative dimer interface [polypeptide binding]; other site
487214005419	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
487214005420	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487214005421	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487214005422	Utp21 specific WD40 associated putative domain; Region: Utp21; pfam04192
487214005423	nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528
487214005424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214005425	dimer interface [polypeptide binding]; other site
487214005426	conserved gate region; other site
487214005427	ABC-ATPase subunit interface; other site
487214005428	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
487214005429	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
487214005430	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
487214005431	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214005432	Walker A/P-loop; other site
487214005433	ATP binding site [chemical binding]; other site
487214005434	Q-loop/lid; other site
487214005435	ABC transporter signature motif; other site
487214005436	Walker B; other site
487214005437	D-loop; other site
487214005438	H-loop/switch region; other site
487214005439	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
487214005440	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
487214005441	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
487214005442	Enterocin A Immunity; Region: EntA_Immun; pfam08951
487214005443	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
487214005444	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
487214005445	oligomer interface [polypeptide binding]; other site
487214005446	active site
487214005447	metal binding site [ion binding]; metal-binding site
487214005448	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
487214005449	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
487214005450	ABC-ATPase subunit  interface; other site
487214005451	dimer interface [polypeptide binding]; other site
487214005452	putative PBP binding regions; other site
487214005453	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
487214005454	ABC-ATPase subunit  interface; other site
487214005455	dimer interface [polypeptide binding]; other site
487214005456	putative PBP binding regions; other site
487214005457	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
487214005458	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
487214005459	Walker A/P-loop; other site
487214005460	ATP binding site [chemical binding]; other site
487214005461	Q-loop/lid; other site
487214005462	ABC transporter signature motif; other site
487214005463	Walker B; other site
487214005464	D-loop; other site
487214005465	H-loop/switch region; other site
487214005466	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
487214005467	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
487214005468	putative ligand binding residues [chemical binding]; other site
487214005469	hypothetical protein; Validated; Region: PRK00041
487214005470	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
487214005471	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
487214005472	RNA binding surface [nucleotide binding]; other site
487214005473	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
487214005474	active site
487214005475	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
487214005476	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
487214005477	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
487214005478	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
487214005479	DNA binding site [nucleotide binding]
487214005480	Int/Topo IB signature motif; other site
487214005481	active site
487214005482	catalytic residues [active]
487214005483	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
487214005484	FOG: CBS domain [General function prediction only]; Region: COG0517
487214005485	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
487214005486	active site
487214005487	metal binding site [ion binding]; metal-binding site
487214005488	homotetramer interface [polypeptide binding]; other site
487214005489	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
487214005490	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
487214005491	active site
487214005492	dimerization interface [polypeptide binding]; other site
487214005493	glutamate racemase; Provisional; Region: PRK00865
487214005494	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
487214005495	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
487214005496	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
487214005497	Ca binding site [ion binding]; other site
487214005498	active site
487214005499	catalytic site [active]
487214005500	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
487214005501	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
487214005502	active site turn [active]
487214005503	phosphorylation site [posttranslational modification]
487214005504	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
487214005505	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
487214005506	HPr interaction site; other site
487214005507	glycerol kinase (GK) interaction site [polypeptide binding]; other site
487214005508	active site
487214005509	phosphorylation site [posttranslational modification]
487214005510	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487214005511	DNA-binding site [nucleotide binding]; DNA binding site
487214005512	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
487214005513	UTRA domain; Region: UTRA; pfam07702
487214005514	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
487214005515	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
487214005516	Walker A/P-loop; other site
487214005517	ATP binding site [chemical binding]; other site
487214005518	Q-loop/lid; other site
487214005519	ABC transporter signature motif; other site
487214005520	Walker B; other site
487214005521	D-loop; other site
487214005522	H-loop/switch region; other site
487214005523	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
487214005524	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
487214005525	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
487214005526	Walker A/P-loop; other site
487214005527	ATP binding site [chemical binding]; other site
487214005528	Q-loop/lid; other site
487214005529	ABC transporter signature motif; other site
487214005530	Walker B; other site
487214005531	D-loop; other site
487214005532	H-loop/switch region; other site
487214005533	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
487214005534	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
487214005535	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
487214005536	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214005537	dimer interface [polypeptide binding]; other site
487214005538	conserved gate region; other site
487214005539	putative PBP binding loops; other site
487214005540	ABC-ATPase subunit interface; other site
487214005541	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
487214005542	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214005543	dimer interface [polypeptide binding]; other site
487214005544	conserved gate region; other site
487214005545	putative PBP binding loops; other site
487214005546	ABC-ATPase subunit interface; other site
487214005547	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
487214005548	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
487214005549	peptide binding site [polypeptide binding]; other site
487214005550	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
487214005551	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
487214005552	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
487214005553	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
487214005554	active site
487214005555	homodimer interface [polypeptide binding]; other site
487214005556	catalytic site [active]
487214005557	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
487214005558	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214005559	dimer interface [polypeptide binding]; other site
487214005560	conserved gate region; other site
487214005561	putative PBP binding loops; other site
487214005562	ABC-ATPase subunit interface; other site
487214005563	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214005564	dimer interface [polypeptide binding]; other site
487214005565	conserved gate region; other site
487214005566	putative PBP binding loops; other site
487214005567	ABC-ATPase subunit interface; other site
487214005568	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
487214005569	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
487214005570	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
487214005571	Melibiase; Region: Melibiase; pfam02065
487214005572	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
487214005573	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487214005574	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
487214005575	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
487214005576	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
487214005577	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487214005578	DNA-binding site [nucleotide binding]; DNA binding site
487214005579	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
487214005580	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
487214005581	recombination regulator RecX; Provisional; Region: recX; PRK14135
487214005582	hypothetical protein; Provisional; Region: PRK13662
487214005583	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
487214005584	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
487214005585	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
487214005586	ring oligomerisation interface [polypeptide binding]; other site
487214005587	ATP/Mg binding site [chemical binding]; other site
487214005588	stacking interactions; other site
487214005589	hinge regions; other site
487214005590	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
487214005591	oligomerisation interface [polypeptide binding]; other site
487214005592	mobile loop; other site
487214005593	roof hairpin; other site
487214005594	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
487214005595	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
487214005596	dimer interface [polypeptide binding]; other site
487214005597	ssDNA binding site [nucleotide binding]; other site
487214005598	tetramer (dimer of dimers) interface [polypeptide binding]; other site
487214005599	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
487214005600	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
487214005601	putative NAD(P) binding site [chemical binding]; other site
487214005602	homodimer interface [polypeptide binding]; other site
487214005603	homotetramer interface [polypeptide binding]; other site
487214005604	active site
487214005605	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
487214005606	putative tRNA-binding site [nucleotide binding]; other site
487214005607	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
487214005608	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
487214005609	catalytic residues [active]
487214005610	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
487214005611	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
487214005612	LytTr DNA-binding domain; Region: LytTR; pfam04397
487214005613	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
487214005614	active site
487214005615	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4898
487214005616	MarR family; Region: MarR_2; pfam12802
487214005617	Transcriptional regulators [Transcription]; Region: MarR; COG1846
487214005618	hypothetical protein; Provisional; Region: PRK12378
487214005619	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
487214005620	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
487214005621	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
487214005622	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
487214005623	putative active site [active]
487214005624	catalytic site [active]
487214005625	putative metal binding site [ion binding]; other site
487214005626	oligomer interface [polypeptide binding]; other site
487214005627	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
487214005628	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
487214005629	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
487214005630	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214005631	Walker A/P-loop; other site
487214005632	ATP binding site [chemical binding]; other site
487214005633	Q-loop/lid; other site
487214005634	ABC transporter signature motif; other site
487214005635	Walker B; other site
487214005636	D-loop; other site
487214005637	H-loop/switch region; other site
487214005638	TOBE domain; Region: TOBE_2; pfam08402
487214005639	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
487214005640	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214005641	dimer interface [polypeptide binding]; other site
487214005642	conserved gate region; other site
487214005643	putative PBP binding loops; other site
487214005644	ABC-ATPase subunit interface; other site
487214005645	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214005646	dimer interface [polypeptide binding]; other site
487214005647	conserved gate region; other site
487214005648	putative PBP binding loops; other site
487214005649	ABC-ATPase subunit interface; other site
487214005650	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
487214005651	MgtC family; Region: MgtC; pfam02308
487214005652	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
487214005653	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214005654	motif II; other site
487214005655	Transcriptional regulators [Transcription]; Region: PurR; COG1609
487214005656	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
487214005657	DNA binding site [nucleotide binding]
487214005658	domain linker motif; other site
487214005659	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
487214005660	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
487214005661	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
487214005662	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
487214005663	Domain of unknown function (DUF955); Region: DUF955; cl01076
487214005664	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
487214005665	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214005666	non-specific DNA binding site [nucleotide binding]; other site
487214005667	salt bridge; other site
487214005668	sequence-specific DNA binding site [nucleotide binding]; other site
487214005669	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712
487214005670	substrate binding site [chemical binding]; other site
487214005671	amidase catalytic site [active]
487214005672	Zn binding residues [ion binding]; other site
487214005673	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214005674	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
487214005675	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214005676	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
487214005677	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
487214005678	recombinase A; Provisional; Region: recA; PRK09354
487214005679	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
487214005680	hexamer interface [polypeptide binding]; other site
487214005681	Walker A motif; other site
487214005682	ATP binding site [chemical binding]; other site
487214005683	Walker B motif; other site
487214005684	competence damage-inducible protein A; Provisional; Region: PRK00549
487214005685	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
487214005686	putative MPT binding site; other site
487214005687	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
487214005688	Transcriptional regulator [Transcription]; Region: LytR; COG1316
487214005689	putative acetyltransferase YhhY; Provisional; Region: PRK10140
487214005690	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
487214005691	Coenzyme A binding pocket [chemical binding]; other site
487214005692	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
487214005693	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
487214005694	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
487214005695	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214005696	non-specific DNA binding site [nucleotide binding]; other site
487214005697	salt bridge; other site
487214005698	sequence-specific DNA binding site [nucleotide binding]; other site
487214005699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
487214005700	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
487214005701	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
487214005702	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
487214005703	Walker A/P-loop; other site
487214005704	ATP binding site [chemical binding]; other site
487214005705	Q-loop/lid; other site
487214005706	ABC transporter signature motif; other site
487214005707	Walker B; other site
487214005708	D-loop; other site
487214005709	H-loop/switch region; other site
487214005710	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
487214005711	active site
487214005712	multimer interface [polypeptide binding]; other site
487214005713	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
487214005714	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
487214005715	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
487214005716	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
487214005717	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
487214005718	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
487214005719	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
487214005720	G-loop; other site
487214005721	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
487214005722	DNA binding site [nucleotide binding]
487214005723	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
487214005724	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
487214005725	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
487214005726	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
487214005727	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
487214005728	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
487214005729	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
487214005730	RPB1 interaction site [polypeptide binding]; other site
487214005731	RPB10 interaction site [polypeptide binding]; other site
487214005732	RPB11 interaction site [polypeptide binding]; other site
487214005733	RPB3 interaction site [polypeptide binding]; other site
487214005734	RPB12 interaction site [polypeptide binding]; other site
487214005735	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
487214005736	Domain of unknown function DUF21; Region: DUF21; pfam01595
487214005737	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
487214005738	Transporter associated domain; Region: CorC_HlyC; smart01091
487214005739	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
487214005740	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
487214005741	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
487214005742	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
487214005743	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
487214005744	hinge; other site
487214005745	active site
487214005746	Protein of unknown function (DUF1146); Region: DUF1146; pfam06612
487214005747	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
487214005748	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
487214005749	protein binding site [polypeptide binding]; other site
487214005750	Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669
487214005751	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
487214005752	active site
487214005753	(T/H)XGH motif; other site
487214005754	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
487214005755	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214005756	S-adenosylmethionine binding site [chemical binding]; other site
487214005757	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
487214005758	dimer interface [polypeptide binding]; other site
487214005759	active site
487214005760	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
487214005761	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
487214005762	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
487214005763	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
487214005764	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
487214005765	acylphosphatase; Provisional; Region: PRK14434
487214005766	OxaA-like protein precursor; Provisional; Region: PRK02463
487214005767	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
487214005768	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
487214005769	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
487214005770	FeS/SAM binding site; other site
487214005771	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
487214005772	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
487214005773	active site
487214005774	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
487214005775	substrate binding site [chemical binding]; other site
487214005776	catalytic residues [active]
487214005777	dimer interface [polypeptide binding]; other site
487214005778	pur operon repressor; Provisional; Region: PRK09213
487214005779	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
487214005780	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487214005781	active site
487214005782	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
487214005783	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
487214005784	generic binding surface II; other site
487214005785	generic binding surface I; other site
487214005786	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
487214005787	Zn2+ binding site [ion binding]; other site
487214005788	Mg2+ binding site [ion binding]; other site
487214005789	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
487214005790	RmuC family; Region: RmuC; pfam02646
487214005791	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
487214005792	Thiamine pyrophosphokinase; Region: TPK; cd07995
487214005793	active site
487214005794	dimerization interface [polypeptide binding]; other site
487214005795	thiamine binding site [chemical binding]; other site
487214005796	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
487214005797	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
487214005798	substrate binding site [chemical binding]; other site
487214005799	hexamer interface [polypeptide binding]; other site
487214005800	metal binding site [ion binding]; metal-binding site
487214005801	GTPase RsgA; Reviewed; Region: PRK00098
487214005802	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
487214005803	RNA binding site [nucleotide binding]; other site
487214005804	homodimer interface [polypeptide binding]; other site
487214005805	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
487214005806	GTPase/Zn-binding domain interface [polypeptide binding]; other site
487214005807	GTP/Mg2+ binding site [chemical binding]; other site
487214005808	G4 box; other site
487214005809	G5 box; other site
487214005810	G1 box; other site
487214005811	Switch I region; other site
487214005812	G2 box; other site
487214005813	G3 box; other site
487214005814	Switch II region; other site
487214005815	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
487214005816	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214005817	S-adenosylmethionine binding site [chemical binding]; other site
487214005818	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
487214005819	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
487214005820	Walker A/P-loop; other site
487214005821	ATP binding site [chemical binding]; other site
487214005822	Q-loop/lid; other site
487214005823	ABC transporter signature motif; other site
487214005824	Walker B; other site
487214005825	D-loop; other site
487214005826	H-loop/switch region; other site
487214005827	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
487214005828	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
487214005829	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891
487214005830	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
487214005831	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214005832	non-specific DNA binding site [nucleotide binding]; other site
487214005833	salt bridge; other site
487214005834	sequence-specific DNA binding site [nucleotide binding]; other site
487214005835	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
487214005836	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
487214005837	putative active site [active]
487214005838	putative metal binding site [ion binding]; other site
487214005839	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
487214005840	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
487214005841	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
487214005842	active site
487214005843	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
487214005844	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
487214005845	aminotransferase AlaT; Validated; Region: PRK09265
487214005846	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
487214005847	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487214005848	homodimer interface [polypeptide binding]; other site
487214005849	catalytic residue [active]
487214005850	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
487214005851	Ligand Binding Site [chemical binding]; other site
487214005852	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
487214005853	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214005854	motif II; other site
487214005855	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214005856	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
487214005857	putative nucleotide binding site [chemical binding]; other site
487214005858	putative metal binding site [ion binding]; other site
487214005859	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
487214005860	active site
487214005861	homotetramer interface [polypeptide binding]; other site
487214005862	homodimer interface [polypeptide binding]; other site
487214005863	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
487214005864	catabolite control protein A; Region: ccpA; TIGR01481
487214005865	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
487214005866	DNA binding site [nucleotide binding]
487214005867	domain linker motif; other site
487214005868	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
487214005869	dimerization interface [polypeptide binding]; other site
487214005870	effector binding site; other site
487214005871	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
487214005872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487214005873	active site
487214005874	phosphorylation site [posttranslational modification]
487214005875	intermolecular recognition site; other site
487214005876	dimerization interface [polypeptide binding]; other site
487214005877	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
487214005878	DNA binding residues [nucleotide binding]
487214005879	dimerization interface [polypeptide binding]; other site
487214005880	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
487214005881	Histidine kinase; Region: HisKA_3; pfam07730
487214005882	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214005883	Mg2+ binding site [ion binding]; other site
487214005884	G-X-G motif; other site
487214005885	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
487214005886	ABC-2 type transporter; Region: ABC2_membrane; cl17235
487214005887	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
487214005888	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
487214005889	Walker A/P-loop; other site
487214005890	ATP binding site [chemical binding]; other site
487214005891	Q-loop/lid; other site
487214005892	ABC transporter signature motif; other site
487214005893	Walker B; other site
487214005894	D-loop; other site
487214005895	H-loop/switch region; other site
487214005896	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
487214005897	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
487214005898	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
487214005899	putative homodimer interface [polypeptide binding]; other site
487214005900	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
487214005901	heterodimer interface [polypeptide binding]; other site
487214005902	homodimer interface [polypeptide binding]; other site
487214005903	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
487214005904	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
487214005905	Transglycosylase; Region: Transgly; pfam00912
487214005906	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
487214005907	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
487214005908	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
487214005909	active site
487214005910	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
487214005911	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
487214005912	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
487214005913	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
487214005914	FtsX-like permease family; Region: FtsX; pfam02687
487214005915	Helix-turn-helix domain; Region: HTH_28; pfam13518
487214005916	Winged helix-turn helix; Region: HTH_29; pfam13551
487214005917	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559
487214005918	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
487214005919	dimerization interface [polypeptide binding]; other site
487214005920	active site
487214005921	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
487214005922	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
487214005923	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
487214005924	Walker A/P-loop; other site
487214005925	ATP binding site [chemical binding]; other site
487214005926	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
487214005927	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
487214005928	DNA-binding site [nucleotide binding]; DNA binding site
487214005929	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
487214005930	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
487214005931	beta-galactosidase; Region: BGL; TIGR03356
487214005932	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
487214005933	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
487214005934	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
487214005935	active site
487214005936	P-loop; other site
487214005937	phosphorylation site [posttranslational modification]
487214005938	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
487214005939	methionine cluster; other site
487214005940	active site
487214005941	phosphorylation site [posttranslational modification]
487214005942	metal binding site [ion binding]; metal-binding site
487214005943	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
487214005944	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
487214005945	putative catalytic cysteine [active]
487214005946	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
487214005947	putative active site [active]
487214005948	metal binding site [ion binding]; metal-binding site
487214005949	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
487214005950	MORN repeat; Region: MORN; cl14787
487214005951	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
487214005952	Low molecular weight phosphatase family; Region: LMWPc; cd00115
487214005953	active site
487214005954	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
487214005955	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
487214005956	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
487214005957	TPP-binding site [chemical binding]; other site
487214005958	dimer interface [polypeptide binding]; other site
487214005959	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
487214005960	PYR/PP interface [polypeptide binding]; other site
487214005961	dimer interface [polypeptide binding]; other site
487214005962	TPP binding site [chemical binding]; other site
487214005963	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
487214005964	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
487214005965	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
487214005966	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
487214005967	PRD domain; Region: PRD; pfam00874
487214005968	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
487214005969	active site
487214005970	P-loop; other site
487214005971	phosphorylation site [posttranslational modification]
487214005972	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
487214005973	L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145
487214005974	intersubunit interface [polypeptide binding]; other site
487214005975	active site
487214005976	Zn2+ binding site [ion binding]; other site
487214005977	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
487214005978	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
487214005979	AP (apurinic/apyrimidinic) site pocket; other site
487214005980	DNA interaction; other site
487214005981	Metal-binding active site; metal-binding site
487214005982	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
487214005983	active site
487214005984	dimer interface [polypeptide binding]; other site
487214005985	magnesium binding site [ion binding]; other site
487214005986	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
487214005987	active site
487214005988	phosphorylation site [posttranslational modification]
487214005989	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
487214005990	active site
487214005991	P-loop; other site
487214005992	phosphorylation site [posttranslational modification]
487214005993	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
487214005994	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
487214005995	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
487214005996	G-X-X-G motif; other site
487214005997	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
487214005998	RxxxH motif; other site
487214005999	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
487214006000	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
487214006001	ribonuclease P; Reviewed; Region: rnpA; PRK00499
487214006002	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
487214006003	propionate/acetate kinase; Provisional; Region: PRK12379
487214006004	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
487214006005	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214006006	S-adenosylmethionine binding site [chemical binding]; other site
487214006007	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
487214006008	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
487214006009	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
487214006010	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
487214006011	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
487214006012	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
487214006013	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
487214006014	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
487214006015	Walker A motif; other site
487214006016	ATP binding site [chemical binding]; other site
487214006017	Walker B motif; other site
487214006018	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
487214006019	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
487214006020	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
487214006021	catalytic Zn binding site [ion binding]; other site
487214006022	structural Zn binding site [ion binding]; other site
487214006023	NAD(P) binding site [chemical binding]; other site
487214006024	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
487214006025	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
487214006026	active site
487214006027	dimer interface [polypeptide binding]; other site
487214006028	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
487214006029	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
487214006030	catalytic triad [active]
487214006031	catalytic triad [active]
487214006032	oxyanion hole [active]
487214006033	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
487214006034	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
487214006035	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
487214006036	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
487214006037	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214006038	motif II; other site
487214006039	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
487214006040	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
487214006041	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
487214006042	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
487214006043	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487214006044	catalytic residue [active]
487214006045	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
487214006046	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
487214006047	putative catalytic site [active]
487214006048	putative metal binding site [ion binding]; other site
487214006049	putative phosphate binding site [ion binding]; other site
487214006050	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
487214006051	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
487214006052	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
487214006053	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
487214006054	active site
487214006055	metal binding site [ion binding]; metal-binding site
487214006056	putative replication initiation protein; Region: PHA00330
487214006057	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
487214006058	integrase; Provisional; Region: int; PHA02601
487214006059	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
487214006060	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
487214006061	Int/Topo IB signature motif; other site
487214006062	HD domain; Region: HD_4; pfam13328
487214006063	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
487214006064	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
487214006065	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
487214006066	active site
487214006067	metal binding site [ion binding]; metal-binding site
487214006068	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
487214006069	Transposase; Region: DDE_Tnp_ISL3; pfam01610
487214006070	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
487214006071	active site
487214006072	catalytic motif [active]
487214006073	Zn binding site [ion binding]; other site
487214006074	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
487214006075	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
487214006076	active site
487214006077	HIGH motif; other site
487214006078	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
487214006079	active site
487214006080	KMSKS motif; other site
487214006081	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
487214006082	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
487214006083	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
487214006084	active site
487214006085	dimer interface [polypeptide binding]; other site
487214006086	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
487214006087	dimer interface [polypeptide binding]; other site
487214006088	active site
487214006089	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
487214006090	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
487214006091	catalytic triad [active]
487214006092	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
487214006093	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
487214006094	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214006095	Walker A/P-loop; other site
487214006096	ATP binding site [chemical binding]; other site
487214006097	Q-loop/lid; other site
487214006098	ABC transporter signature motif; other site
487214006099	Walker B; other site
487214006100	D-loop; other site
487214006101	H-loop/switch region; other site
487214006102	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
487214006103	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
487214006104	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
487214006105	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
487214006106	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214006107	Walker A/P-loop; other site
487214006108	ATP binding site [chemical binding]; other site
487214006109	Q-loop/lid; other site
487214006110	ABC transporter signature motif; other site
487214006111	Walker B; other site
487214006112	D-loop; other site
487214006113	H-loop/switch region; other site
487214006114	DNA mismatch repair protein MutS; Region: mutS1; TIGR01070
487214006115	MutS domain I; Region: MutS_I; pfam01624
487214006116	MutS domain II; Region: MutS_II; pfam05188
487214006117	MutS domain III; Region: MutS_III; pfam05192
487214006118	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
487214006119	Walker A/P-loop; other site
487214006120	ATP binding site [chemical binding]; other site
487214006121	Q-loop/lid; other site
487214006122	ABC transporter signature motif; other site
487214006123	Walker B; other site
487214006124	D-loop; other site
487214006125	H-loop/switch region; other site
487214006126	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
487214006127	arginine repressor; Region: argR_whole; TIGR01529
487214006128	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
487214006129	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
487214006130	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
487214006131	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
487214006132	active site
487214006133	HIGH motif; other site
487214006134	KMSK motif region; other site
487214006135	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
487214006136	tRNA binding surface [nucleotide binding]; other site
487214006137	anticodon binding site; other site
487214006138	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
487214006139	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
487214006140	Uncharacterized conserved protein [Function unknown]; Region: COG3542
487214006141	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487214006142	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487214006143	active site
487214006144	phosphorylation site [posttranslational modification]
487214006145	intermolecular recognition site; other site
487214006146	dimerization interface [polypeptide binding]; other site
487214006147	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487214006148	DNA binding site [nucleotide binding]
487214006149	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
487214006150	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487214006151	dimer interface [polypeptide binding]; other site
487214006152	phosphorylation site [posttranslational modification]
487214006153	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214006154	ATP binding site [chemical binding]; other site
487214006155	G-X-G motif; other site
487214006156	PBP superfamily domain; Region: PBP_like_2; cl17296
487214006157	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
487214006158	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
487214006159	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214006160	dimer interface [polypeptide binding]; other site
487214006161	conserved gate region; other site
487214006162	putative PBP binding loops; other site
487214006163	ABC-ATPase subunit interface; other site
487214006164	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
487214006165	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214006166	dimer interface [polypeptide binding]; other site
487214006167	conserved gate region; other site
487214006168	putative PBP binding loops; other site
487214006169	ABC-ATPase subunit interface; other site
487214006170	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
487214006171	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
487214006172	Walker A/P-loop; other site
487214006173	ATP binding site [chemical binding]; other site
487214006174	Q-loop/lid; other site
487214006175	ABC transporter signature motif; other site
487214006176	Walker B; other site
487214006177	D-loop; other site
487214006178	H-loop/switch region; other site
487214006179	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
487214006180	PhoU domain; Region: PhoU; pfam01895
487214006181	PhoU domain; Region: PhoU; pfam01895
487214006182	DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502
487214006183	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
487214006184	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
487214006185	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
487214006186	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
487214006187	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
487214006188	active site
487214006189	tetramer interface; other site
487214006190	Rhomboid family; Region: Rhomboid; pfam01694
487214006191	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
487214006192	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
487214006193	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
487214006194	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
487214006195	metal binding site [ion binding]; metal-binding site
487214006196	putative dimer interface [polypeptide binding]; other site
487214006197	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
487214006198	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
487214006199	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
487214006200	trimer interface [polypeptide binding]; other site
487214006201	active site
487214006202	substrate binding site [chemical binding]; other site
487214006203	CoA binding site [chemical binding]; other site
487214006204	EamA-like transporter family; Region: EamA; pfam00892
487214006205	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
487214006206	Transglycosylase; Region: Transgly; pfam00912
487214006207	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
487214006208	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
487214006209	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
487214006210	active site
487214006211	HIGH motif; other site
487214006212	dimer interface [polypeptide binding]; other site
487214006213	KMSKS motif; other site
487214006214	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
487214006215	RNA binding surface [nucleotide binding]; other site
487214006216	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
487214006217	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
487214006218	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
487214006219	motif II; other site
487214006220	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
487214006221	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
487214006222	S-adenosylmethionine binding site [chemical binding]; other site
487214006223	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
487214006224	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
487214006225	4-alpha-glucanotransferase; Provisional; Region: PRK14508
487214006226	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
487214006227	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
487214006228	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214006229	dimer interface [polypeptide binding]; other site
487214006230	conserved gate region; other site
487214006231	putative PBP binding loops; other site
487214006232	ABC-ATPase subunit interface; other site
487214006233	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
487214006234	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
487214006235	dimer interface [polypeptide binding]; other site
487214006236	conserved gate region; other site
487214006237	putative PBP binding loops; other site
487214006238	ABC-ATPase subunit interface; other site
487214006239	Predicted integral membrane protein [Function unknown]; Region: COG5521
487214006240	Transcriptional regulators [Transcription]; Region: PurR; COG1609
487214006241	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
487214006242	DNA binding site [nucleotide binding]
487214006243	domain linker motif; other site
487214006244	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
487214006245	putative dimerization interface [polypeptide binding]; other site
487214006246	putative ligand binding site [chemical binding]; other site
487214006247	Uncharacterized conserved protein [Function unknown]; Region: COG1284
487214006248	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
487214006249	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
487214006250	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
487214006251	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
487214006252	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
487214006253	dimer interface [polypeptide binding]; other site
487214006254	anticodon binding site; other site
487214006255	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
487214006256	homodimer interface [polypeptide binding]; other site
487214006257	motif 1; other site
487214006258	active site
487214006259	motif 2; other site
487214006260	GAD domain; Region: GAD; pfam02938
487214006261	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
487214006262	motif 3; other site
487214006263	CAAX protease self-immunity; Region: Abi; pfam02517
487214006264	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
487214006265	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214006266	non-specific DNA binding site [nucleotide binding]; other site
487214006267	salt bridge; other site
487214006268	sequence-specific DNA binding site [nucleotide binding]; other site
487214006269	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
487214006270	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
487214006271	dimer interface [polypeptide binding]; other site
487214006272	motif 1; other site
487214006273	active site
487214006274	motif 2; other site
487214006275	motif 3; other site
487214006276	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
487214006277	anticodon binding site; other site
487214006278	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
487214006279	non-specific DNA binding site [nucleotide binding]; other site
487214006280	salt bridge; other site
487214006281	sequence-specific DNA binding site [nucleotide binding]; other site
487214006282	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
487214006283	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
487214006284	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
487214006285	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
487214006286	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
487214006287	PYR/PP interface [polypeptide binding]; other site
487214006288	dimer interface [polypeptide binding]; other site
487214006289	TPP binding site [chemical binding]; other site
487214006290	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
487214006291	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
487214006292	TPP-binding site [chemical binding]; other site
487214006293	dimer interface [polypeptide binding]; other site
487214006294	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
487214006295	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
487214006296	active site
487214006297	P-loop; other site
487214006298	phosphorylation site [posttranslational modification]
487214006299	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
487214006300	PRD domain; Region: PRD; pfam00874
487214006301	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
487214006302	active site
487214006303	P-loop; other site
487214006304	phosphorylation site [posttranslational modification]
487214006305	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
487214006306	active site
487214006307	phosphorylation site [posttranslational modification]
487214006308	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
487214006309	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
487214006310	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
487214006311	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
487214006312	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
487214006313	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
487214006314	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
487214006315	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006316	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006317	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006318	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006319	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006320	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006321	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006322	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
487214006323	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
487214006324	putative active site [active]
487214006325	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
487214006326	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
487214006327	nucleotide binding site [chemical binding]; other site
487214006328	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
487214006329	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
487214006330	active site
487214006331	metal binding site [ion binding]; metal-binding site
487214006332	homodimer interface [polypeptide binding]; other site
487214006333	catalytic site [active]
487214006334	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
487214006335	Uncharacterized conserved protein [Function unknown]; Region: COG3538
487214006336	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
487214006337	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
487214006338	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
487214006339	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
487214006340	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
487214006341	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
487214006342	arginine deiminase; Provisional; Region: PRK01388
487214006343	ornithine carbamoyltransferase; Validated; Region: PRK02102
487214006344	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
487214006345	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
487214006346	carbamate kinase; Reviewed; Region: PRK12686
487214006347	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
487214006348	putative substrate binding site [chemical binding]; other site
487214006349	nucleotide binding site [chemical binding]; other site
487214006350	nucleotide binding site [chemical binding]; other site
487214006351	homodimer interface [polypeptide binding]; other site
487214006352	Predicted membrane protein [Function unknown]; Region: COG1288
487214006353	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
487214006354	hypothetical protein; Provisional; Region: PRK07205
487214006355	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
487214006356	active site
487214006357	metal binding site [ion binding]; metal-binding site
487214006358	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
487214006359	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
487214006360	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
487214006361	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
487214006362	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
487214006363	dimer interface [polypeptide binding]; other site
487214006364	active site
487214006365	metal binding site [ion binding]; metal-binding site
487214006366	L-fucose isomerase; Provisional; Region: fucI; PRK10991
487214006367	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
487214006368	hexamer (dimer of trimers) interface [polypeptide binding]; other site
487214006369	trimer interface [polypeptide binding]; other site
487214006370	substrate binding site [chemical binding]; other site
487214006371	Mn binding site [ion binding]; other site
487214006372	Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306
487214006373	Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307
487214006374	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
487214006375	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
487214006376	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
487214006377	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
487214006378	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
487214006379	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
487214006380	active site
487214006381	phosphorylation site [posttranslational modification]
487214006382	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
487214006383	active pocket/dimerization site; other site
487214006384	active site
487214006385	phosphorylation site [posttranslational modification]
487214006386	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
487214006387	L-fuculose phosphate aldolase; Provisional; Region: PRK06833
487214006388	intersubunit interface [polypeptide binding]; other site
487214006389	active site
487214006390	Zn2+ binding site [ion binding]; other site
487214006391	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
487214006392	N- and C-terminal domain interface [polypeptide binding]; other site
487214006393	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
487214006394	active site
487214006395	putative catalytic site [active]
487214006396	metal binding site [ion binding]; metal-binding site
487214006397	ATP binding site [chemical binding]; other site
487214006398	carbohydrate binding site [chemical binding]; other site
487214006399	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
487214006400	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
487214006401	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
487214006402	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
487214006403	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
487214006404	metal binding site [ion binding]; metal-binding site
487214006405	YodA lipocalin-like domain; Region: YodA; pfam09223
487214006406	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
487214006407	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
487214006408	ABC-ATPase subunit  interface; other site
487214006409	dimer interface [polypeptide binding]; other site
487214006410	putative PBP binding regions; other site
487214006411	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
487214006412	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
487214006413	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
487214006414	putative DNA binding site [nucleotide binding]; other site
487214006415	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
487214006416	DltD N-terminal region; Region: DltD_N; pfam04915
487214006417	DltD central region; Region: DltD_M; pfam04918
487214006418	DltD C-terminal region; Region: DltD_C; pfam04914
487214006419	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
487214006420	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
487214006421	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
487214006422	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
487214006423	acyl-activating enzyme (AAE) consensus motif; other site
487214006424	AMP binding site [chemical binding]; other site
487214006425	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
487214006426	putative substrate translocation pore; other site
487214006427	group II catalytic intron
487214006428	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
487214006429	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
487214006430	putative active site [active]
487214006431	putative NTP binding site [chemical binding]; other site
487214006432	putative nucleic acid binding site [nucleotide binding]; other site
487214006433	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
487214006434	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
487214006435	amphipathic channel; other site
487214006436	Asn-Pro-Ala signature motifs; other site
487214006437	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
487214006438	glycerol kinase; Provisional; Region: glpK; PRK00047
487214006439	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
487214006440	N- and C-terminal domain interface [polypeptide binding]; other site
487214006441	active site
487214006442	MgATP binding site [chemical binding]; other site
487214006443	catalytic site [active]
487214006444	metal binding site [ion binding]; metal-binding site
487214006445	glycerol binding site [chemical binding]; other site
487214006446	homotetramer interface [polypeptide binding]; other site
487214006447	homodimer interface [polypeptide binding]; other site
487214006448	FBP binding site [chemical binding]; other site
487214006449	protein IIAGlc interface [polypeptide binding]; other site
487214006450	Mga helix-turn-helix domain; Region: Mga; pfam05043
487214006451	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
487214006452	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
487214006453	dimerization interface [polypeptide binding]; other site
487214006454	domain crossover interface; other site
487214006455	redox-dependent activation switch; other site
487214006456	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
487214006457	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
487214006458	FMN binding site [chemical binding]; other site
487214006459	active site
487214006460	catalytic residues [active]
487214006461	substrate binding site [chemical binding]; other site
487214006462	RICH domain; Region: RICH; pfam05062
487214006463	RICH domain; Region: RICH; pfam05062
487214006464	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
487214006465	Transposase; Region: DDE_Tnp_ISL3; pfam01610
487214006466	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
487214006467	RICH domain; Region: RICH; pfam05062
487214006468	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006469	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006470	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006471	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006472	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006473	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006474	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
487214006475	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006476	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006477	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
487214006478	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
487214006479	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
487214006480	dimerization interface [polypeptide binding]; other site
487214006481	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
487214006482	dimer interface [polypeptide binding]; other site
487214006483	phosphorylation site [posttranslational modification]
487214006484	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
487214006485	ATP binding site [chemical binding]; other site
487214006486	Mg2+ binding site [ion binding]; other site
487214006487	G-X-G motif; other site
487214006488	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
487214006489	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487214006490	active site
487214006491	phosphorylation site [posttranslational modification]
487214006492	intermolecular recognition site; other site
487214006493	dimerization interface [polypeptide binding]; other site
487214006494	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
487214006495	DNA binding site [nucleotide binding]
487214006496	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
487214006497	Clp amino terminal domain; Region: Clp_N; pfam02861
487214006498	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214006499	Walker A motif; other site
487214006500	ATP binding site [chemical binding]; other site
487214006501	Walker B motif; other site
487214006502	arginine finger; other site
487214006503	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
487214006504	Walker A motif; other site
487214006505	ATP binding site [chemical binding]; other site
487214006506	Walker B motif; other site
487214006507	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
487214006508	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
487214006509	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
487214006510	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
487214006511	Walker A/P-loop; other site
487214006512	ATP binding site [chemical binding]; other site
487214006513	Q-loop/lid; other site
487214006514	ABC transporter signature motif; other site
487214006515	Walker B; other site
487214006516	D-loop; other site
487214006517	H-loop/switch region; other site
487214006518	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
487214006519	NMT1/THI5 like; Region: NMT1; pfam09084
487214006520	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
487214006521	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
487214006522	Uncharacterized conserved protein [Function unknown]; Region: COG0011
487214006523	Surface antigen [General function prediction only]; Region: COG3942
487214006524	CHAP domain; Region: CHAP; pfam05257
487214006525	Bacterial SH3 domain; Region: SH3_5; pfam08460
487214006526	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
487214006527	Bacterial SH3 domain; Region: SH3_5; pfam08460
487214006528	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
487214006529	Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466
487214006530	replicative DNA helicase; Provisional; Region: PRK05748
487214006531	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
487214006532	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
487214006533	Walker A motif; other site
487214006534	ATP binding site [chemical binding]; other site
487214006535	Walker B motif; other site
487214006536	DNA binding loops [nucleotide binding]
487214006537	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
487214006538	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
487214006539	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
487214006540	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
487214006541	30S subunit binding site; other site
487214006542	comF family protein; Region: comF; TIGR00201
487214006543	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
487214006544	active site
487214006545	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
487214006546	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
487214006547	ATP binding site [chemical binding]; other site
487214006548	putative Mg++ binding site [ion binding]; other site
487214006549	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
487214006550	nucleotide binding region [chemical binding]; other site
487214006551	ATP-binding site [chemical binding]; other site
487214006552	Uncharacterized conserved protein [Function unknown]; Region: COG1739
487214006553	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
487214006554	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
487214006555	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
487214006556	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
487214006557	dimer interface [polypeptide binding]; other site
487214006558	pyridoxal 5'-phosphate binding site [chemical binding]; other site
487214006559	catalytic residue [active]
487214006560	elongation factor Ts; Provisional; Region: tsf; PRK09377
487214006561	UBA/TS-N domain; Region: UBA; pfam00627
487214006562	Elongation factor TS; Region: EF_TS; pfam00889
487214006563	Elongation factor TS; Region: EF_TS; pfam00889
487214006564	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
487214006565	rRNA interaction site [nucleotide binding]; other site
487214006566	S8 interaction site; other site
487214006567	putative laminin-1 binding site; other site
487214006568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
487214006569	Septum formation initiator; Region: DivIC; cl17659
487214006570	Surface antigen [General function prediction only]; Region: COG3942
487214006571	CHAP domain; Region: CHAP; pfam05257
487214006572	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
487214006573	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
487214006574	rod shape-determining protein MreC; Region: MreC; pfam04085
487214006575	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
487214006576	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
487214006577	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
487214006578	Walker A/P-loop; other site
487214006579	ATP binding site [chemical binding]; other site
487214006580	Q-loop/lid; other site
487214006581	ABC transporter signature motif; other site
487214006582	Walker B; other site
487214006583	D-loop; other site
487214006584	H-loop/switch region; other site
487214006585	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
487214006586	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
487214006587	Helix-turn-helix domain; Region: HTH_25; pfam13413
487214006588	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
487214006589	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
487214006590	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
487214006591	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
487214006592	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
487214006593	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
487214006594	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
487214006595	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
487214006596	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
487214006597	Walker A/P-loop; other site
487214006598	ATP binding site [chemical binding]; other site
487214006599	Q-loop/lid; other site
487214006600	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
487214006601	ABC transporter signature motif; other site
487214006602	Walker B; other site
487214006603	D-loop; other site
487214006604	H-loop/switch region; other site
487214006605	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
487214006606	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
487214006607	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
487214006608	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
487214006609	active site
487214006610	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
487214006611	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
487214006612	active site
487214006613	HIGH motif; other site
487214006614	dimer interface [polypeptide binding]; other site
487214006615	KMSKS motif; other site
487214006616	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
487214006617	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487214006618	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487214006619	ABC transporter; Region: ABC_tran_2; pfam12848
487214006620	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
487214006621	Predicted membrane protein [Function unknown]; Region: COG4485
487214006622	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
487214006623	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
487214006624	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
487214006625	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
487214006626	active site
487214006627	phosphorylation site [posttranslational modification]
487214006628	intermolecular recognition site; other site
487214006629	dimerization interface [polypeptide binding]; other site
487214006630	LytTr DNA-binding domain; Region: LytTR; pfam04397
487214006631	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
487214006632	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
487214006633	COMC family; Region: ComC; pfam03047
487214006634	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
487214006635	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
487214006636	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
487214006637	protein binding site [polypeptide binding]; other site
487214006638	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
487214006639	ParB-like nuclease domain; Region: ParBc; pfam02195
487214006640	KorB domain; Region: KorB; pfam08535