-- dump date   	20140620_084705
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
869269000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
869269000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
869269000003	Walker A motif; other site
869269000004	ATP binding site [chemical binding]; other site
869269000005	Walker B motif; other site
869269000006	arginine finger; other site
869269000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
869269000008	DnaA box-binding interface [nucleotide binding]; other site
869269000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
869269000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
869269000011	putative DNA binding surface [nucleotide binding]; other site
869269000012	dimer interface [polypeptide binding]; other site
869269000013	beta-clamp/clamp loader binding surface; other site
869269000014	beta-clamp/translesion DNA polymerase binding surface; other site
869269000015	Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864
869269000016	GTP-binding protein YchF; Reviewed; Region: PRK09601
869269000017	YchF GTPase; Region: YchF; cd01900
869269000018	G1 box; other site
869269000019	GTP/Mg2+ binding site [chemical binding]; other site
869269000020	Switch I region; other site
869269000021	G2 box; other site
869269000022	Switch II region; other site
869269000023	G3 box; other site
869269000024	G4 box; other site
869269000025	G5 box; other site
869269000026	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
869269000027	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
869269000028	putative active site [active]
869269000029	catalytic residue [active]
869269000030	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
869269000031	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
869269000032	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869269000033	ATP binding site [chemical binding]; other site
869269000034	putative Mg++ binding site [ion binding]; other site
869269000035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869269000036	nucleotide binding region [chemical binding]; other site
869269000037	ATP-binding site [chemical binding]; other site
869269000038	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
869269000039	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
869269000040	RNA binding surface [nucleotide binding]; other site
869269000041	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
869269000042	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
869269000043	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
869269000044	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
869269000045	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
869269000046	Ligand Binding Site [chemical binding]; other site
869269000047	TilS substrate C-terminal domain; Region: TilS_C; smart00977
869269000048	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
869269000049	active site
869269000050	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
869269000051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
869269000052	Walker A motif; other site
869269000053	ATP binding site [chemical binding]; other site
869269000054	Walker B motif; other site
869269000055	arginine finger; other site
869269000056	Peptidase family M41; Region: Peptidase_M41; pfam01434
869269000059	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
869269000060	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
869269000061	GDP-binding site [chemical binding]; other site
869269000062	ACT binding site; other site
869269000063	IMP binding site; other site
869269000064	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
869269000065	nucleoside/Zn binding site; other site
869269000066	dimer interface [polypeptide binding]; other site
869269000067	catalytic motif [active]
869269000068	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
869269000069	trimer interface [polypeptide binding]; other site
869269000070	active site
869269000071	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
869269000072	catalytic core [active]
869269000073	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
869269000074	DNA repair protein RadA; Provisional; Region: PRK11823
869269000075	Walker A motif; other site
869269000076	ATP binding site [chemical binding]; other site
869269000077	Walker B motif; other site
869269000078	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
869269000079	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
869269000080	active site clefts [active]
869269000081	zinc binding site [ion binding]; other site
869269000082	dimer interface [polypeptide binding]; other site
869269000083	Frameshift mutation relative to orthologue in TIGR4; TIGR4 orthologue likely to also be a pseudogene due to an independent frameshift mutation in the upstream region
869269000084	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
869269000085	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
869269000086	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
869269000087	active site
869269000088	coordinates determined manually using correlation scores plot
869269000089	DNA polymerase I; Provisional; Region: PRK05755
869269000090	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
869269000091	active site
869269000092	metal binding site 1 [ion binding]; metal-binding site
869269000093	putative 5' ssDNA interaction site; other site
869269000094	metal binding site 3; metal-binding site
869269000095	metal binding site 2 [ion binding]; metal-binding site
869269000096	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
869269000097	putative DNA binding site [nucleotide binding]; other site
869269000098	putative metal binding site [ion binding]; other site
869269000099	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
869269000100	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
869269000101	active site
869269000102	DNA binding site [nucleotide binding]
869269000103	catalytic site [active]
869269000104	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
869269000105	Predicted membrane protein [Function unknown]; Region: COG2855
869269000106	aromatic amino acid aminotransferase; Validated; Region: PRK07309
869269000107	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
869269000108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869269000109	homodimer interface [polypeptide binding]; other site
869269000110	catalytic residue [active]
869269000111	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
869269000112	Recombination protein O N terminal; Region: RecO_N; pfam11967
869269000113	Recombination protein O C terminal; Region: RecO_C; pfam02565
869269000114	putative phosphate acyltransferase; Provisional; Region: PRK05331
869269000116	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
869269000117	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
869269000118	putative active site [active]
869269000119	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
869269000120	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269000121	Walker A/P-loop; other site
869269000122	ATP binding site [chemical binding]; other site
869269000123	Q-loop/lid; other site
869269000124	ABC transporter signature motif; other site
869269000125	Walker B; other site
869269000126	D-loop; other site
869269000127	H-loop/switch region; other site
869269000128	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
869269000129	HlyD family secretion protein; Region: HlyD_3; pfam13437
869269000130	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
869269000131	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
869269000132	ATP binding site [chemical binding]; other site
869269000133	active site
869269000134	substrate binding site [chemical binding]; other site
869269000135	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
869269000136	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
869269000137	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
869269000138	dimerization interface [polypeptide binding]; other site
869269000139	ATP binding site [chemical binding]; other site
869269000140	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
869269000141	dimerization interface [polypeptide binding]; other site
869269000142	ATP binding site [chemical binding]; other site
869269000143	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
869269000144	putative active site [active]
869269000145	catalytic triad [active]
869269000146	amidophosphoribosyltransferase; Provisional; Region: PRK07272
869269000147	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
869269000148	active site
869269000149	tetramer interface [polypeptide binding]; other site
869269000150	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
869269000151	active site
869269000152	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
869269000153	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
869269000154	dimerization interface [polypeptide binding]; other site
869269000155	putative ATP binding site [chemical binding]; other site
869269000156	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
869269000157	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
869269000158	active site
869269000159	substrate binding site [chemical binding]; other site
869269000160	cosubstrate binding site; other site
869269000161	catalytic site [active]
869269000162	VanZ like family; Region: VanZ; pfam04892
869269000163	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
869269000164	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
869269000165	purine monophosphate binding site [chemical binding]; other site
869269000166	dimer interface [polypeptide binding]; other site
869269000167	putative catalytic residues [active]
869269000168	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
869269000169	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
869269000170	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
869269000171	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
869269000172	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
869269000173	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
869269000174	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
869269000175	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
869269000176	ATP-grasp domain; Region: ATP-grasp; pfam02222
869269000177	adenylosuccinate lyase; Provisional; Region: PRK07492
869269000178	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
869269000179	tetramer interface [polypeptide binding]; other site
869269000180	active site
869269000181	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
869269000182	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
869269000183	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
869269000184	active site
869269000185	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
869269000186	active site
869269000187	G5 domain; Region: G5; pfam07501
869269000188	G5 domain; Region: G5; pfam07501
869269000189	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
869269000190	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
869269000191	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
869269000192	DNA-binding site [nucleotide binding]; DNA binding site
869269000193	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
869269000194	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
869269000195	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
869269000196	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
869269000197	active site
869269000198	phosphorylation site [posttranslational modification]
869269000199	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
869269000200	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
869269000201	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
869269000202	active pocket/dimerization site; other site
869269000203	active site
869269000204	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
869269000205	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
869269000206	dimer interface [polypeptide binding]; other site
869269000207	active site
869269000208	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
869269000209	putative active site [active]
869269000210	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
869269000211	active site
869269000212	catalytic residues [active]
869269000213	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
869269000214	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
869269000215	putative metal binding site [ion binding]; other site
869269000216	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
869269000217	active site
869269000218	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
869269000219	putative homodimer interface [polypeptide binding]; other site
869269000220	putative homotetramer interface [polypeptide binding]; other site
869269000221	putative allosteric switch controlling residues; other site
869269000222	putative metal binding site [ion binding]; other site
869269000223	putative homodimer-homodimer interface [polypeptide binding]; other site
869269000224	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
869269000225	active site residue [active]
869269000226	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
869269000227	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
869269000228	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
869269000229	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
869269000230	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
869269000231	TrkA-N domain; Region: TrkA_N; pfam02254
869269000233	Fibronectin-binding repeat; Region: SSURE; pfam11966
869269000234	Fibronectin-binding repeat; Region: SSURE; pfam11966
869269000235	Fibronectin-binding repeat; Region: SSURE; pfam11966
869269000236	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
869269000237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
869269000238	active site
869269000239	phosphorylation site [posttranslational modification]
869269000240	intermolecular recognition site; other site
869269000241	dimerization interface [polypeptide binding]; other site
869269000242	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
869269000243	DNA binding site [nucleotide binding]
869269000244	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
869269000245	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
869269000246	dimerization interface [polypeptide binding]; other site
869269000247	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
869269000248	dimer interface [polypeptide binding]; other site
869269000249	phosphorylation site [posttranslational modification]
869269000250	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269000251	ATP binding site [chemical binding]; other site
869269000252	Mg2+ binding site [ion binding]; other site
869269000253	G-X-G motif; other site
869269000254	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
869269000255	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
869269000256	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
869269000257	RNA binding surface [nucleotide binding]; other site
869269000259	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
869269000260	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269000261	dimer interface [polypeptide binding]; other site
869269000262	conserved gate region; other site
869269000263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
869269000264	ABC-ATPase subunit interface; other site
869269000265	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
869269000266	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269000267	dimer interface [polypeptide binding]; other site
869269000268	conserved gate region; other site
869269000269	putative PBP binding loops; other site
869269000270	ABC-ATPase subunit interface; other site
869269000271	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
869269000272	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
869269000273	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
869269000274	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
869269000275	active site residue [active]
869269000276	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
869269000277	Domain of unknown function (DUF4299); Region: DUF4299; pfam14132
869269000278	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
869269000279	Predicted membrane protein [Function unknown]; Region: COG4709
869269000280	Predicted transcriptional regulators [Transcription]; Region: COG1695
869269000281	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
869269000282	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
869269000283	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
869269000284	putative substrate translocation pore; other site
869269000285	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
869269000286	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
869269000287	Ligand binding site; other site
869269000288	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
869269000289	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
869269000290	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
869269000291	NAD(P) binding site [chemical binding]; other site
869269000292	homodimer interface [polypeptide binding]; other site
869269000293	substrate binding site [chemical binding]; other site
869269000294	active site
869269000295	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
869269000296	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269000297	active site
869269000298	motif I; other site
869269000299	motif II; other site
869269000300	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
869269000301	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
869269000302	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
869269000303	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
869269000304	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
869269000305	putative L-serine binding site [chemical binding]; other site
869269000306	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
869269000307	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
869269000308	Very similar to SPN23F01241; both appear to encode the C terminal fragments of a conserved hypothetical protein, on the basis of comparisons to S. pneumoniae OXC141
869269000309	Leucine-zipper of ternary complex factor MIP1; Region: Lzipper-MIP1; pfam14389
869269000310	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269000311	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269000312	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269000313	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269000314	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
869269000315	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269000316	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269000317	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
869269000318	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269000319	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269000320	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
869269000321	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
869269000322	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
869269000323	nudix motif; other site
869269000324	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
869269000325	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
869269000326	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
869269000327	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
869269000328	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
869269000329	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
869269000330	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
869269000331	hypothetical protein; Provisional; Region: PRK13667
869269000333	class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949
869269000334	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
869269000335	Glycoprotease family; Region: Peptidase_M22; pfam00814
869269000336	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
869269000337	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869269000338	Coenzyme A binding pocket [chemical binding]; other site
869269000339	UGMP family protein; Validated; Region: PRK09604
869269000340	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
869269000341	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
869269000343	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
869269000344	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269000345	Transposase; Region: DDE_Tnp_ISL3; pfam01610
869269000350	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
869269000351	Ligand Binding Site [chemical binding]; other site
869269000352	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
869269000353	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
869269000354	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
869269000355	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
869269000356	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869269000357	non-specific DNA binding site [nucleotide binding]; other site
869269000358	salt bridge; other site
869269000359	sequence-specific DNA binding site [nucleotide binding]; other site
869269000360	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
869269000361	CAAX protease self-immunity; Region: Abi; pfam02517
869269000362	CAAX protease self-immunity; Region: Abi; pfam02517
869269000363	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
869269000364	Predicted membrane protein [Function unknown]; Region: COG4392
869269000365	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
869269000366	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
869269000367	substrate binding pocket [chemical binding]; other site
869269000368	membrane-bound complex binding site; other site
869269000369	hinge residues; other site
869269000370	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
869269000371	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
869269000372	substrate binding pocket [chemical binding]; other site
869269000373	membrane-bound complex binding site; other site
869269000374	hinge residues; other site
869269000375	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
869269000376	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
869269000377	hypothetical protein; Provisional; Region: PRK06446
869269000378	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
869269000379	metal binding site [ion binding]; metal-binding site
869269000380	dimer interface [polypeptide binding]; other site
869269000381	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
869269000382	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
869269000383	Walker A/P-loop; other site
869269000384	ATP binding site [chemical binding]; other site
869269000385	Q-loop/lid; other site
869269000386	ABC transporter signature motif; other site
869269000387	Walker B; other site
869269000388	D-loop; other site
869269000389	H-loop/switch region; other site
869269000390	NIL domain; Region: NIL; pfam09383
869269000391	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
869269000392	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
869269000393	Predicted integral membrane protein [Function unknown]; Region: COG5578
869269000394	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
869269000395	HAMP domain; Region: HAMP; pfam00672
869269000396	Histidine kinase; Region: His_kinase; pfam06580
869269000397	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269000398	ATP binding site [chemical binding]; other site
869269000399	Mg2+ binding site [ion binding]; other site
869269000400	G-X-G motif; other site
869269000401	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
869269000402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
869269000403	active site
869269000404	phosphorylation site [posttranslational modification]
869269000405	intermolecular recognition site; other site
869269000406	dimerization interface [polypeptide binding]; other site
869269000407	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869269000408	flavoprotein NrdI; Provisional; Region: PRK02551
869269000409	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
869269000410	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269000411	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269000412	Integrase core domain; Region: rve; pfam00665
869269000413	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
869269000414	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
869269000415	LytTr DNA-binding domain; Region: LytTR; smart00850
869269000416	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
869269000417	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869269000418	non-specific DNA binding site [nucleotide binding]; other site
869269000419	salt bridge; other site
869269000420	sequence-specific DNA binding site [nucleotide binding]; other site
869269000421	Phosphopantothenoylcysteine synthetase/decarboxylase [Coenzyme metabolism]; Region: Dfp; COG0452
869269000422	Flavoprotein; Region: Flavoprotein; pfam02441
869269000423	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
869269000424	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
869269000425	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
869269000426	catalytic residue [active]
869269000427	H+ Antiporter protein; Region: 2A0121; TIGR00900
869269000428	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
869269000429	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
869269000430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269000431	ATP binding site [chemical binding]; other site
869269000432	Mg2+ binding site [ion binding]; other site
869269000433	G-X-G motif; other site
869269000434	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
869269000435	ATP binding site [chemical binding]; other site
869269000436	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
869269000437	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
869269000438	homopentamer interface [polypeptide binding]; other site
869269000439	active site
869269000440	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
869269000441	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
869269000442	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
869269000443	dimerization interface [polypeptide binding]; other site
869269000444	active site
869269000445	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
869269000446	Lumazine binding domain; Region: Lum_binding; pfam00677
869269000447	Lumazine binding domain; Region: Lum_binding; pfam00677
869269000448	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
869269000449	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
869269000450	catalytic motif [active]
869269000451	Zn binding site [ion binding]; other site
869269000452	RibD C-terminal domain; Region: RibD_C; cl17279
869269000453	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
869269000454	RuvA N terminal domain; Region: RuvA_N; pfam01330
869269000455	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
869269000456	CAAX protease self-immunity; Region: Abi; pfam02517
869269000457	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
869269000458	putative dimer interface [polypeptide binding]; other site
869269000459	catalytic triad [active]
869269000460	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
869269000461	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
869269000462	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
869269000463	Cl binding site [ion binding]; other site
869269000464	oligomer interface [polypeptide binding]; other site
869269000465	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
869269000466	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
869269000467	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
869269000468	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
869269000469	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
869269000470	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
869269000471	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
869269000472	active site
869269000473	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269000474	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269000475	Integrase core domain; Region: rve; pfam00665
869269000476	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
869269000477	ArsC family; Region: ArsC; pfam03960
869269000478	putative catalytic residues [active]
869269000479	thiol/disulfide switch; other site
869269000480	hypothetical protein; Provisional; Region: PRK05473
869269000481	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
869269000482	hypothetical protein; Provisional; Region: PRK13678
869269000483	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
869269000484	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
869269000485	Bacterial lipoprotein; Region: DUF3642; pfam12182
869269000486	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
869269000487	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
869269000488	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
869269000489	putative active site [active]
869269000490	catalytic site [active]
869269000491	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
869269000492	putative active site [active]
869269000493	catalytic site [active]
869269000494	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
869269000495	ATP cone domain; Region: ATP-cone; pfam03477
869269000496	Class III ribonucleotide reductase; Region: RNR_III; cd01675
869269000497	effector binding site; other site
869269000498	active site
869269000499	Zn binding site [ion binding]; other site
869269000500	glycine loop; other site
869269000501	Predicted acetyltransferase [General function prediction only]; Region: COG3981
869269000502	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
869269000503	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
869269000504	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
869269000505	FeS/SAM binding site; other site
869269000506	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
869269000507	active site
869269000508	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
869269000509	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
869269000510	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
869269000511	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
869269000512	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
869269000513	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
869269000514	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
869269000515	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
869269000516	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
869269000517	putative translocon binding site; other site
869269000518	protein-rRNA interface [nucleotide binding]; other site
869269000519	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
869269000520	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
869269000521	G-X-X-G motif; other site
869269000522	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
869269000523	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
869269000524	23S rRNA interface [nucleotide binding]; other site
869269000525	5S rRNA interface [nucleotide binding]; other site
869269000526	putative antibiotic binding site [chemical binding]; other site
869269000527	L25 interface [polypeptide binding]; other site
869269000528	L27 interface [polypeptide binding]; other site
869269000529	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
869269000530	23S rRNA interface [nucleotide binding]; other site
869269000531	putative translocon interaction site; other site
869269000532	signal recognition particle (SRP54) interaction site; other site
869269000533	L23 interface [polypeptide binding]; other site
869269000534	trigger factor interaction site; other site
869269000535	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
869269000536	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
869269000537	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
869269000538	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
869269000539	RNA binding site [nucleotide binding]; other site
869269000540	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
869269000541	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
869269000542	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
869269000543	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
869269000544	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
869269000545	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
869269000546	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
869269000547	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
869269000548	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
869269000549	5S rRNA interface [nucleotide binding]; other site
869269000550	L27 interface [polypeptide binding]; other site
869269000551	23S rRNA interface [nucleotide binding]; other site
869269000552	L5 interface [polypeptide binding]; other site
869269000553	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
869269000554	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
869269000555	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
869269000556	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
869269000557	23S rRNA binding site [nucleotide binding]; other site
869269000558	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
869269000559	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
869269000560	SecY translocase; Region: SecY; pfam00344
869269000561	adenylate kinase; Reviewed; Region: adk; PRK00279
869269000562	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
869269000563	AMP-binding site [chemical binding]; other site
869269000564	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
869269000565	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
869269000566	rRNA binding site [nucleotide binding]; other site
869269000567	predicted 30S ribosome binding site; other site
869269000568	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
869269000569	30S ribosomal protein S13; Region: bact_S13; TIGR03631
869269000570	30S ribosomal protein S11; Validated; Region: PRK05309
869269000571	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
869269000572	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
869269000573	alphaNTD homodimer interface [polypeptide binding]; other site
869269000574	alphaNTD - beta interaction site [polypeptide binding]; other site
869269000575	alphaNTD - beta' interaction site [polypeptide binding]; other site
869269000576	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
869269000577	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
869269000578	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
869269000579	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
869269000580	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
869269000581	catalytic core [active]
869269000582	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
869269000583	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
869269000584	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269000585	dimer interface [polypeptide binding]; other site
869269000586	conserved gate region; other site
869269000587	ABC-ATPase subunit interface; other site
869269000589	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
869269000590	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269000591	Walker A/P-loop; other site
869269000592	ATP binding site [chemical binding]; other site
869269000593	Q-loop/lid; other site
869269000594	ABC transporter signature motif; other site
869269000595	Walker B; other site
869269000596	D-loop; other site
869269000597	H-loop/switch region; other site
869269000598	TOBE domain; Region: TOBE_2; pfam08402
869269000599	Appears to have been disrupted through the insertion of a RUP element
869269000600	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
869269000601	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869269000602	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
869269000603	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
869269000604	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
869269000605	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
869269000606	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
869269000607	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
869269000608	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
869269000609	active site
869269000610	methionine cluster; other site
869269000611	phosphorylation site [posttranslational modification]
869269000612	metal binding site [ion binding]; metal-binding site
869269000613	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
869269000614	active site
869269000615	P-loop; other site
869269000616	phosphorylation site [posttranslational modification]
869269000617	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
869269000618	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
869269000619	Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882
869269000620	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
869269000621	dimer interface [polypeptide binding]; other site
869269000622	active site
869269000623	glycine loop; other site
869269000624	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
869269000625	active site
869269000626	intersubunit interactions; other site
869269000627	catalytic residue [active]
869269000628	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
869269000629	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
869269000630	dimer interface [polypeptide binding]; other site
869269000631	active site
869269000632	metal binding site [ion binding]; metal-binding site
869269000633	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
869269000634	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
869269000635	HIGH motif; other site
869269000636	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
869269000637	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
869269000638	active site
869269000639	KMSKS motif; other site
869269000640	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
869269000641	tRNA binding surface [nucleotide binding]; other site
869269000642	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
869269000643	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
869269000644	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
869269000645	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869269000646	Coenzyme A binding pocket [chemical binding]; other site
869269000647	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
869269000648	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
869269000649	Walker A motif; other site
869269000650	ATP binding site [chemical binding]; other site
869269000651	Walker B motif; other site
869269000652	arginine finger; other site
869269000653	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
869269000654	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575
869269000655	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
869269000656	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
869269000657	catalytic residue [active]
869269000658	putative FPP diphosphate  binding site; other site
869269000659	putative FPP binding hydrophobic cleft; other site
869269000660	dimer interface [polypeptide binding]; other site
869269000661	putative IPP diphosphate binding site; other site
869269000662	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
869269000663	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
869269000664	RIP metalloprotease RseP; Region: TIGR00054
869269000665	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
869269000666	active site
869269000667	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
869269000668	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
869269000669	putative substrate binding region [chemical binding]; other site
869269000670	prolyl-tRNA synthetase; Provisional; Region: PRK09194
869269000671	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
869269000672	dimer interface [polypeptide binding]; other site
869269000673	motif 1; other site
869269000674	active site
869269000675	motif 2; other site
869269000676	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
869269000677	putative deacylase active site [active]
869269000678	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
869269000679	active site
869269000680	motif 3; other site
869269000681	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
869269000682	anticodon binding site; other site
869269000683	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
869269000684	beta-galactosidase; Region: BGL; TIGR03356
869269000685	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
869269000686	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
869269000687	glutaminase active site [active]
869269000688	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
869269000689	dimer interface [polypeptide binding]; other site
869269000690	active site
869269000691	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
869269000692	dimer interface [polypeptide binding]; other site
869269000693	active site
869269000694	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
869269000695	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
869269000696	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
869269000697	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
869269000698	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
869269000699	carbohydrate binding site [chemical binding]; other site
869269000700	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
869269000701	carbohydrate binding site [chemical binding]; other site
869269000702	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
869269000703	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
869269000704	Ca binding site [ion binding]; other site
869269000705	active site
869269000706	catalytic site [active]
869269000707	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269000708	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269000709	Integrase core domain; Region: rve; pfam00665
869269000710	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
869269000711	S17 interaction site [polypeptide binding]; other site
869269000712	S8 interaction site; other site
869269000713	16S rRNA interaction site [nucleotide binding]; other site
869269000714	streptomycin interaction site [chemical binding]; other site
869269000715	23S rRNA interaction site [nucleotide binding]; other site
869269000716	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
869269000717	30S ribosomal protein S7; Validated; Region: PRK05302
869269000718	elongation factor G; Reviewed; Region: PRK00007
869269000719	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
869269000720	G1 box; other site
869269000721	putative GEF interaction site [polypeptide binding]; other site
869269000722	GTP/Mg2+ binding site [chemical binding]; other site
869269000723	Switch I region; other site
869269000724	G2 box; other site
869269000725	G3 box; other site
869269000726	Switch II region; other site
869269000727	G4 box; other site
869269000728	G5 box; other site
869269000729	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
869269000730	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
869269000731	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
869269000732	DNA polymerase III PolC; Validated; Region: polC; PRK00448
869269000733	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
869269000734	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
869269000735	generic binding surface II; other site
869269000736	generic binding surface I; other site
869269000737	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
869269000738	active site
869269000739	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
869269000740	active site
869269000741	catalytic site [active]
869269000742	substrate binding site [chemical binding]; other site
869269000743	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
869269000744	putative PHP Thumb interface [polypeptide binding]; other site
869269000745	active site
869269000746	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
869269000748	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
869269000749	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
869269000750	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
869269000751	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
869269000752	RNA binding surface [nucleotide binding]; other site
869269000753	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
869269000754	active site
869269000755	uracil binding [chemical binding]; other site
869269000756	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
869269000757	trimer interface [polypeptide binding]; other site
869269000758	active site
869269000759	G bulge; other site
869269000760	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
869269000761	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
869269000762	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
869269000763	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
869269000764	active pocket/dimerization site; other site
869269000765	active site
869269000766	phosphorylation site [posttranslational modification]
869269000767	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
869269000768	active site
869269000769	phosphorylation site [posttranslational modification]
869269000770	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
869269000771	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
869269000772	NAD binding site [chemical binding]; other site
869269000773	substrate binding site [chemical binding]; other site
869269000774	catalytic Zn binding site [ion binding]; other site
869269000775	tetramer interface [polypeptide binding]; other site
869269000776	structural Zn binding site [ion binding]; other site
869269000777	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
869269000778	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269000779	active site
869269000780	motif I; other site
869269000781	motif II; other site
869269000782	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
869269000783	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
869269000784	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269000785	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269000786	Integrase core domain; Region: rve; pfam00665
869269000787	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
869269000788	dihydropteroate synthase; Region: DHPS; TIGR01496
869269000789	substrate binding pocket [chemical binding]; other site
869269000790	dimer interface [polypeptide binding]; other site
869269000791	inhibitor binding site; inhibition site
869269000792	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
869269000793	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
869269000794	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
869269000795	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
869269000796	homodecamer interface [polypeptide binding]; other site
869269000797	GTP cyclohydrolase I; Provisional; Region: PLN03044
869269000798	active site
869269000799	putative catalytic site residues [active]
869269000800	zinc binding site [ion binding]; other site
869269000801	GTP-CH-I/GFRP interaction surface; other site
869269000802	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
869269000803	homooctamer interface [polypeptide binding]; other site
869269000804	active site
869269000805	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
869269000806	catalytic center binding site [active]
869269000807	ATP binding site [chemical binding]; other site
869269000808	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
869269000809	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
869269000810	23S rRNA interface [nucleotide binding]; other site
869269000811	L3 interface [polypeptide binding]; other site
869269000812	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
869269000813	6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589
869269000814	beta-galactosidase; Region: BGL; TIGR03356
869269000815	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
869269000816	HTH domain; Region: HTH_11; pfam08279
869269000817	Mga helix-turn-helix domain; Region: Mga; pfam05043
869269000818	PRD domain; Region: PRD; pfam00874
869269000819	PRD domain; Region: PRD; pfam00874
869269000820	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
869269000821	active site
869269000822	P-loop; other site
869269000823	phosphorylation site [posttranslational modification]
869269000824	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
869269000825	active site
869269000826	phosphorylation site [posttranslational modification]
869269000827	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
869269000828	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
869269000829	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
869269000830	This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595
869269000831	putative active site [active]
869269000832	putative catalytic site [active]
869269000833	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
869269000834	catalytic residues [active]
869269000835	dimer interface [polypeptide binding]; other site
869269000836	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
869269000837	substrate binding site [chemical binding]; other site
869269000838	catalytic residues [active]
869269000840	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
869269000841	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
869269000842	active site
869269000843	intersubunit interface [polypeptide binding]; other site
869269000844	catalytic residue [active]
869269000845	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
869269000846	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
869269000847	substrate binding site [chemical binding]; other site
869269000848	ATP binding site [chemical binding]; other site
869269000849	hypothetical protein; Provisional; Region: PRK09273
869269000850	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
869269000851	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
869269000852	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
869269000853	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
869269000854	NADP binding site [chemical binding]; other site
869269000855	homodimer interface [polypeptide binding]; other site
869269000856	active site
869269000857	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
869269000858	active pocket/dimerization site; other site
869269000859	active site
869269000860	phosphorylation site [posttranslational modification]
869269000861	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
869269000862	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
869269000863	active site
869269000864	phosphorylation site [posttranslational modification]
869269000865	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
869269000866	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
869269000867	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
869269000868	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
869269000869	Transcriptional regulators [Transcription]; Region: PurR; COG1609
869269000870	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
869269000871	DNA binding site [nucleotide binding]
869269000872	domain linker motif; other site
869269000873	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
869269000874	putative dimerization interface [polypeptide binding]; other site
869269000875	putative ligand binding site [chemical binding]; other site
869269000876	Protein of unknown function (DUF3278); Region: DUF3278; pfam11683
869269000877	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869269000878	non-specific DNA binding site [nucleotide binding]; other site
869269000879	salt bridge; other site
869269000880	sequence-specific DNA binding site [nucleotide binding]; other site
869269000881	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
869269000882	MraW methylase family; Region: Methyltransf_5; pfam01795
869269000883	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
869269000884	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
869269000885	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
869269000886	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
869269000887	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
869269000888	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
869269000889	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
869269000890	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
869269000891	Mg++ binding site [ion binding]; other site
869269000892	putative catalytic motif [active]
869269000893	putative substrate binding site [chemical binding]; other site
869269000894	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
869269000895	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
869269000896	Walker A motif; other site
869269000897	ATP binding site [chemical binding]; other site
869269000898	Walker B motif; other site
869269000899	arginine finger; other site
869269000900	UvrB/uvrC motif; Region: UVR; pfam02151
869269000901	MoxR-like ATPases [General function prediction only]; Region: COG0714
869269000902	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
869269000903	Walker A motif; other site
869269000904	ATP binding site [chemical binding]; other site
869269000905	Walker B motif; other site
869269000906	arginine finger; other site
869269000907	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
869269000908	YcaO-like family; Region: YcaO; pfam02624
869269000909	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
869269000910	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269000911	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269000912	Integrase core domain; Region: rve; pfam00665
869269000913	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
869269000914	putative FMN binding site [chemical binding]; other site
869269000915	NADPH bind site [chemical binding]; other site
869269000917	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
869269000918	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
869269000919	putative active site [active]
869269000920	putative NTP binding site [chemical binding]; other site
869269000921	putative nucleic acid binding site [nucleotide binding]; other site
869269000922	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
869269000923	LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854
869269000924	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
869269000925	hypothetical protein; Provisional; Region: PRK13663
869269000926	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
869269000927	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
869269000928	Ca binding site [ion binding]; other site
869269000929	active site
869269000930	catalytic site [active]
869269000933	DNA polymerase processivity factor; Region: DNA_PPF; pfam02916
869269000934	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
869269000935	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
869269000936	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
869269000937	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
869269000938	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
869269000939	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
869269000940	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
869269000941	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
869269000942	putative ADP-binding pocket [chemical binding]; other site
869269000943	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
869269000944	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
869269000945	trimer interface [polypeptide binding]; other site
869269000946	active site
869269000947	substrate binding site [chemical binding]; other site
869269000948	CoA binding site [chemical binding]; other site
869269000949	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
869269000950	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
869269000951	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
869269000952	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
869269000953	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
869269000954	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
869269000955	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869269000956	NAD(P) binding site [chemical binding]; other site
869269000957	active site
869269000958	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
869269000959	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
869269000960	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
869269000961	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
869269000962	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
869269000963	Transposase; Region: DDE_Tnp_ISL3; pfam01610
869269000964	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
869269000965	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
869269000966	substrate binding site; other site
869269000967	tetramer interface; other site
869269000968	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
869269000969	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
869269000970	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
869269000971	NAD binding site [chemical binding]; other site
869269000972	substrate binding site [chemical binding]; other site
869269000973	homodimer interface [polypeptide binding]; other site
869269000974	active site
869269000977	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
869269000978	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
869269000979	peptide binding site [polypeptide binding]; other site
869269000980	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
869269000981	Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905
869269000982	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
869269000983	Transglycosylase; Region: Transgly; pfam00912
869269000984	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
869269000985	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
869269000986	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
869269000987	hypothetical protein; Provisional; Region: PRK13660
869269000988	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
869269000989	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
869269000990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
869269000991	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
869269000992	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
869269000993	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
869269000994	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
869269000995	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
869269000996	active site
869269000997	phosphorylation site [posttranslational modification]
869269000998	intermolecular recognition site; other site
869269000999	dimerization interface [polypeptide binding]; other site
869269001000	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
869269001001	DNA binding site [nucleotide binding]
869269001002	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
869269001003	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
869269001004	active site
869269001005	zinc binding site [ion binding]; other site
869269001007	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
869269001008	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
869269001009	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
869269001010	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
869269001011	diphosphomevalonate decarboxylase; Region: PLN02407
869269001012	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
869269001013	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
869269001014	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
869269001015	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
869269001016	homotetramer interface [polypeptide binding]; other site
869269001017	FMN binding site [chemical binding]; other site
869269001018	homodimer contacts [polypeptide binding]; other site
869269001019	putative active site [active]
869269001020	putative substrate binding site [chemical binding]; other site
869269001021	Predicted membrane protein [Function unknown]; Region: COG4758
869269001022	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
869269001023	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
869269001024	Histidine kinase; Region: HisKA_3; pfam07730
869269001025	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269001026	ATP binding site [chemical binding]; other site
869269001027	Mg2+ binding site [ion binding]; other site
869269001028	G-X-G motif; other site
869269001029	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
869269001030	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
869269001031	active site
869269001032	phosphorylation site [posttranslational modification]
869269001033	intermolecular recognition site; other site
869269001034	dimerization interface [polypeptide binding]; other site
869269001035	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
869269001036	DNA binding residues [nucleotide binding]
869269001037	dimerization interface [polypeptide binding]; other site
869269001039	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
869269001040	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
869269001041	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269001042	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269001044	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
869269001045	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
869269001046	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
869269001047	active site
869269001048	P-loop; other site
869269001049	phosphorylation site [posttranslational modification]
869269001050	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
869269001051	active site
869269001052	P-loop; other site
869269001053	phosphorylation site [posttranslational modification]
869269001054	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
869269001055	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
869269001056	active site
869269001057	P-loop; other site
869269001058	phosphorylation site [posttranslational modification]
869269001059	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
869269001060	active site
869269001061	phosphorylation site [posttranslational modification]
869269001062	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
869269001063	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
869269001064	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
869269001065	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
869269001066	trigger factor; Provisional; Region: tig; PRK01490
869269001067	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
869269001068	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
869269001069	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
869269001070	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
869269001071	DNA binding site [nucleotide binding]
869269001072	AAA domain; Region: AAA_30; pfam13604
869269001073	Family description; Region: UvrD_C_2; pfam13538
869269001074	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
869269001075	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
869269001076	Catalytic site [active]
869269001077	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
869269001078	ribonuclease HIII; Provisional; Region: PRK00996
869269001079	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
869269001080	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
869269001081	RNA/DNA hybrid binding site [nucleotide binding]; other site
869269001082	active site
869269001083	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
869269001084	Colicin V production protein; Region: Colicin_V; pfam02674
869269001085	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193
869269001086	MutS domain III; Region: MutS_III; pfam05192
869269001087	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
869269001088	Walker A/P-loop; other site
869269001089	ATP binding site [chemical binding]; other site
869269001090	Q-loop/lid; other site
869269001091	ABC transporter signature motif; other site
869269001092	Walker B; other site
869269001093	D-loop; other site
869269001094	H-loop/switch region; other site
869269001095	Smr domain; Region: Smr; pfam01713
869269001096	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
869269001097	amino acid carrier protein; Region: agcS; TIGR00835
869269001098	Uncharacterized conserved protein [Function unknown]; Region: COG2128
869269001099	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
869269001100	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
869269001101	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
869269001102	gating phenylalanine in ion channel; other site
869269001103	seryl-tRNA synthetase; Provisional; Region: PRK05431
869269001104	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
869269001105	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
869269001106	dimer interface [polypeptide binding]; other site
869269001107	active site
869269001108	motif 1; other site
869269001109	motif 2; other site
869269001110	motif 3; other site
869269001111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687
869269001112	aspartate kinase; Reviewed; Region: PRK09034
869269001113	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
869269001114	putative catalytic residues [active]
869269001115	putative nucleotide binding site [chemical binding]; other site
869269001116	putative aspartate binding site [chemical binding]; other site
869269001117	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
869269001118	allosteric regulatory residue; other site
869269001119	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
869269001120	enoyl-CoA hydratase; Provisional; Region: PRK07260
869269001121	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
869269001122	substrate binding site [chemical binding]; other site
869269001123	oxyanion hole (OAH) forming residues; other site
869269001124	trimer interface [polypeptide binding]; other site
869269001125	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
869269001126	MarR family; Region: MarR_2; pfam12802
869269001127	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
869269001128	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
869269001129	dimer interface [polypeptide binding]; other site
869269001130	active site
869269001131	CoA binding pocket [chemical binding]; other site
869269001132	acyl carrier protein; Provisional; Region: acpP; PRK00982
869269001133	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
869269001134	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
869269001135	FMN binding site [chemical binding]; other site
869269001136	substrate binding site [chemical binding]; other site
869269001137	putative catalytic residue [active]
869269001138	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
869269001139	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
869269001140	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
869269001141	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
869269001142	NAD(P) binding site [chemical binding]; other site
869269001143	homotetramer interface [polypeptide binding]; other site
869269001144	homodimer interface [polypeptide binding]; other site
869269001145	active site
869269001146	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
869269001147	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
869269001148	dimer interface [polypeptide binding]; other site
869269001149	active site
869269001150	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
869269001151	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
869269001152	carboxyltransferase (CT) interaction site; other site
869269001153	biotinylation site [posttranslational modification]; other site
869269001154	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
869269001155	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
869269001156	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
869269001157	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
869269001158	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
869269001159	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
869269001160	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
869269001161	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
869269001162	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
869269001163	CAAX protease self-immunity; Region: Abi; pfam02517
869269001164	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
869269001165	putative RNA binding site [nucleotide binding]; other site
869269001166	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
869269001167	elongation factor P; Validated; Region: PRK00529
869269001168	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
869269001169	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
869269001170	RNA binding site [nucleotide binding]; other site
869269001171	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
869269001172	RNA binding site [nucleotide binding]; other site
869269001173	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
869269001174	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
869269001175	GatB domain; Region: GatB_Yqey; pfam02637
869269001176	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
869269001177	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
869269001178	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
869269001179	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
869269001180	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
869269001181	G1 box; other site
869269001182	putative GEF interaction site [polypeptide binding]; other site
869269001183	GTP/Mg2+ binding site [chemical binding]; other site
869269001184	Switch I region; other site
869269001185	G2 box; other site
869269001186	G3 box; other site
869269001187	Switch II region; other site
869269001188	G4 box; other site
869269001189	G5 box; other site
869269001190	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
869269001192	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
869269001193	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
869269001194	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
869269001195	DAK2 domain; Region: Dak2; pfam02734
869269001196	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282
869269001197	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
869269001198	PYR/PP interface [polypeptide binding]; other site
869269001199	dimer interface [polypeptide binding]; other site
869269001200	TPP binding site [chemical binding]; other site
869269001201	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
869269001202	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
869269001203	TPP-binding site [chemical binding]; other site
869269001204	dimer interface [polypeptide binding]; other site
869269001205	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
869269001206	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
869269001207	putative valine binding site [chemical binding]; other site
869269001208	dimer interface [polypeptide binding]; other site
869269001209	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
869269001210	ketol-acid reductoisomerase; Provisional; Region: PRK05479
869269001211	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
869269001212	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
869269001213	threonine dehydratase; Validated; Region: PRK08639
869269001214	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
869269001215	tetramer interface [polypeptide binding]; other site
869269001216	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869269001217	catalytic residue [active]
869269001218	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
869269001219	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
869269001220	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269001221	Walker A/P-loop; other site
869269001222	ATP binding site [chemical binding]; other site
869269001223	Q-loop/lid; other site
869269001224	ABC transporter signature motif; other site
869269001225	Walker B; other site
869269001226	D-loop; other site
869269001227	H-loop/switch region; other site
869269001228	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
869269001229	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
869269001230	substrate binding pocket [chemical binding]; other site
869269001231	membrane-bound complex binding site; other site
869269001232	hinge residues; other site
869269001233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269001234	dimer interface [polypeptide binding]; other site
869269001235	conserved gate region; other site
869269001236	putative PBP binding loops; other site
869269001237	ABC-ATPase subunit interface; other site
869269001238	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
869269001239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
869269001240	Transposase; Region: DEDD_Tnp_IS110; pfam01548
869269001241	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869269001242	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
869269001243	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
869269001244	active site
869269001245	DNA polymerase IV; Validated; Region: PRK02406
869269001246	DNA binding site [nucleotide binding]
869269001247	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
869269001248	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
869269001250	Transcriptional regulators [Transcription]; Region: MarR; COG1846
869269001251	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
869269001252	non-specific DNA interactions [nucleotide binding]; other site
869269001253	DNA binding site [nucleotide binding]
869269001254	sequence specific DNA binding site [nucleotide binding]; other site
869269001255	putative cAMP binding site [chemical binding]; other site
869269001256	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
869269001257	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
869269001258	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
869269001259	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
869269001260	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
869269001261	beta-galactosidase; Region: BGL; TIGR03356
869269001262	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
869269001263	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
869269001264	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
869269001265	active site
869269001266	P-loop; other site
869269001267	phosphorylation site [posttranslational modification]
869269001268	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
869269001269	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
869269001270	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
869269001271	TrkA-N domain; Region: TrkA_N; pfam02254
869269001272	TrkA-C domain; Region: TrkA_C; pfam02080
869269001273	TrkA-N domain; Region: TrkA_N; pfam02254
869269001274	TrkA-C domain; Region: TrkA_C; pfam02080
869269001275	Uncharacterized conserved protein [Function unknown]; Region: COG1912
869269001276	hypothetical protein; Provisional; Region: PRK13661
869269001277	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
869269001278	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
869269001279	Walker A/P-loop; other site
869269001280	ATP binding site [chemical binding]; other site
869269001281	Q-loop/lid; other site
869269001282	ABC transporter signature motif; other site
869269001283	Walker B; other site
869269001284	D-loop; other site
869269001285	H-loop/switch region; other site
869269001286	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
869269001287	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
869269001288	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
869269001289	Walker A/P-loop; other site
869269001290	ATP binding site [chemical binding]; other site
869269001291	Q-loop/lid; other site
869269001292	ABC transporter signature motif; other site
869269001293	Walker B; other site
869269001294	D-loop; other site
869269001295	H-loop/switch region; other site
869269001296	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
869269001297	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
869269001298	Predicted membrane protein [Function unknown]; Region: COG3601
869269001299	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
869269001300	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
869269001301	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
869269001302	active site
869269001303	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
869269001304	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869269001305	non-specific DNA binding site [nucleotide binding]; other site
869269001306	salt bridge; other site
869269001307	sequence-specific DNA binding site [nucleotide binding]; other site
869269001308	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
869269001309	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
869269001310	ATP binding site [chemical binding]; other site
869269001311	substrate interface [chemical binding]; other site
869269001312	potential frameshift: common BLAST hit: gi|55822301|ref|YP_140742.1| peptide ABC transporter ATP-binding protein/permease
869269001313	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
869269001314	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
869269001315	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269001316	ABC transporter; Region: ABC_tran; pfam00005
869269001317	Q-loop/lid; other site
869269001318	ABC transporter signature motif; other site
869269001319	Walker B; other site
869269001320	D-loop; other site
869269001321	ParB-like nuclease domain; Region: ParBc; cl02129
869269001322	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
869269001323	CTP synthetase; Validated; Region: pyrG; PRK05380
869269001324	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
869269001325	Catalytic site [active]
869269001326	active site
869269001327	UTP binding site [chemical binding]; other site
869269001328	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
869269001329	active site
869269001330	putative oxyanion hole; other site
869269001331	catalytic triad [active]
869269001332	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
869269001333	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
869269001334	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
869269001335	PhoU domain; Region: PhoU; pfam01895
869269001336	PhoU domain; Region: PhoU; pfam01895
869269001337	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
869269001338	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
869269001339	Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins.  The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547
869269001340	putative active site [active]
869269001341	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
869269001342	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
869269001343	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
869269001344	G5 domain; Region: G5; pfam07501
869269001345	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
869269001346	Phosphoglycerate kinase; Region: PGK; pfam00162
869269001347	substrate binding site [chemical binding]; other site
869269001348	hinge regions; other site
869269001349	ADP binding site [chemical binding]; other site
869269001350	catalytic site [active]
869269001351	Predicted membrane protein [Function unknown]; Region: COG4129
869269001352	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
869269001353	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
869269001354	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
869269001355	DNA binding residues [nucleotide binding]
869269001356	putative dimer interface [polypeptide binding]; other site
869269001357	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
869269001358	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
869269001359	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
869269001360	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869269001361	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
869269001362	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
869269001363	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
869269001364	DEAD-like helicases superfamily; Region: DEXDc; smart00487
869269001365	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869269001366	ATP binding site [chemical binding]; other site
869269001367	putative Mg++ binding site [ion binding]; other site
869269001368	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
869269001369	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
869269001370	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
869269001371	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
869269001372	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
869269001373	dimer interface [polypeptide binding]; other site
869269001374	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
869269001375	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
869269001376	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
869269001377	nucleotide binding site [chemical binding]; other site
869269001378	NEF interaction site [polypeptide binding]; other site
869269001379	SBD interface [polypeptide binding]; other site
869269001380	chaperone protein DnaJ; Provisional; Region: PRK14276
869269001381	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
869269001382	HSP70 interaction site [polypeptide binding]; other site
869269001383	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
869269001384	substrate binding site [polypeptide binding]; other site
869269001385	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
869269001386	Zn binding sites [ion binding]; other site
869269001387	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
869269001388	substrate binding site [polypeptide binding]; other site
869269001389	dimer interface [polypeptide binding]; other site
869269001390	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
869269001391	HIT family signature motif; other site
869269001392	catalytic residue [active]
869269001393	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
869269001394	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
869269001395	Walker A/P-loop; other site
869269001396	ATP binding site [chemical binding]; other site
869269001397	Q-loop/lid; other site
869269001398	ABC transporter signature motif; other site
869269001399	Walker B; other site
869269001400	D-loop; other site
869269001401	H-loop/switch region; other site
869269001402	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
869269001403	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
869269001404	LytTr DNA-binding domain; Region: LytTR; pfam04397
869269001405	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
869269001406	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
869269001407	active site
869269001408	phosphorylation site [posttranslational modification]
869269001409	intermolecular recognition site; other site
869269001410	dimerization interface [polypeptide binding]; other site
869269001411	LytTr DNA-binding domain; Region: LytTR; pfam04397
869269001412	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
869269001413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269001414	ATP binding site [chemical binding]; other site
869269001415	Mg2+ binding site [ion binding]; other site
869269001416	G-X-G motif; other site
869269001417	COMC family; Region: ComC; pfam03047
869269001418	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
869269001419	HlyD family secretion protein; Region: HlyD_3; pfam13437
869269001420	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
869269001421	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
869269001422	putative active site [active]
869269001423	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
869269001424	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269001425	Walker A/P-loop; other site
869269001426	ATP binding site [chemical binding]; other site
869269001427	Q-loop/lid; other site
869269001428	ABC transporter signature motif; other site
869269001429	Walker B; other site
869269001430	D-loop; other site
869269001431	H-loop/switch region; other site
869269001432	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
869269001433	CAAX protease self-immunity; Region: Abi; pfam02517
869269001434	CAAX protease self-immunity; Region: Abi; pfam02517
869269001435	Phosphotransferase enzyme family; Region: APH; pfam01636
869269001436	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
869269001437	substrate binding site [chemical binding]; other site
869269001438	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269001439	S-adenosylmethionine binding site [chemical binding]; other site
869269001440	ribosome maturation protein RimP; Reviewed; Region: PRK00092
869269001441	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
869269001442	putative oligomer interface [polypeptide binding]; other site
869269001443	putative RNA binding site [nucleotide binding]; other site
869269001444	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
869269001445	NusA N-terminal domain; Region: NusA_N; pfam08529
869269001446	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
869269001447	RNA binding site [nucleotide binding]; other site
869269001448	homodimer interface [polypeptide binding]; other site
869269001449	NusA-like KH domain; Region: KH_5; pfam13184
869269001450	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
869269001451	G-X-X-G motif; other site
869269001452	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
869269001453	putative RNA binding cleft [nucleotide binding]; other site
869269001454	hypothetical protein; Provisional; Region: PRK07283
869269001455	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
869269001456	translation initiation factor IF-2; Region: IF-2; TIGR00487
869269001457	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
869269001458	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
869269001459	G1 box; other site
869269001460	putative GEF interaction site [polypeptide binding]; other site
869269001461	GTP/Mg2+ binding site [chemical binding]; other site
869269001462	Switch I region; other site
869269001463	G2 box; other site
869269001464	G3 box; other site
869269001465	Switch II region; other site
869269001466	G4 box; other site
869269001467	G5 box; other site
869269001468	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
869269001469	Translation-initiation factor 2; Region: IF-2; pfam11987
869269001470	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
869269001471	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
869269001472	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
869269001473	Transposase; Region: DDE_Tnp_ISL3; pfam01610
869269001474	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
869269001475	Transposase; Region: DDE_Tnp_ISL3; pfam01610
869269001477	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
869269001478	Uncharacterized conserved protein [Function unknown]; Region: COG2461
869269001479	Family of unknown function (DUF438); Region: DUF438; pfam04282
869269001480	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
869269001481	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
869269001482	putative active site [active]
869269001483	heme pocket [chemical binding]; other site
869269001484	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
869269001485	hypothetical protein; Provisional; Region: PRK07758
869269001486	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
869269001487	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
869269001488	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869269001489	Coenzyme A binding pocket [chemical binding]; other site
869269001490	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
869269001491	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
869269001492	active site
869269001493	HIGH motif; other site
869269001494	nucleotide binding site [chemical binding]; other site
869269001495	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
869269001496	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
869269001497	active site
869269001498	KMSKS motif; other site
869269001499	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
869269001500	tRNA binding surface [nucleotide binding]; other site
869269001501	anticodon binding site; other site
869269001502	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
869269001503	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
869269001504	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
869269001505	Fic/DOC family; Region: Fic; pfam02661
869269001506	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
869269001507	putative active site [active]
869269001508	catalytic site [active]
869269001509	transcriptional antiterminator BglG; Provisional; Region: PRK09772
869269001510	CAT RNA binding domain; Region: CAT_RBD; smart01061
869269001511	PRD domain; Region: PRD; pfam00874
869269001512	PRD domain; Region: PRD; pfam00874
869269001513	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
869269001514	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
869269001515	active site turn [active]
869269001516	phosphorylation site [posttranslational modification]
869269001517	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
869269001518	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
869269001519	HPr interaction site; other site
869269001520	glycerol kinase (GK) interaction site [polypeptide binding]; other site
869269001521	active site
869269001522	phosphorylation site [posttranslational modification]
869269001523	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
869269001524	beta-galactosidase; Region: BGL; TIGR03356
869269001525	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
869269001526	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
869269001527	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
869269001528	dimer interface [polypeptide binding]; other site
869269001529	motif 1; other site
869269001530	active site
869269001531	motif 2; other site
869269001532	motif 3; other site
869269001533	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
869269001534	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869269001535	Coenzyme A binding pocket [chemical binding]; other site
869269001536	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
869269001537	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
869269001538	putative tRNA-binding site [nucleotide binding]; other site
869269001539	B3/4 domain; Region: B3_4; pfam03483
869269001540	tRNA synthetase B5 domain; Region: B5; smart00874
869269001541	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
869269001542	dimer interface [polypeptide binding]; other site
869269001543	motif 1; other site
869269001544	motif 3; other site
869269001545	motif 2; other site
869269001546	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
869269001548	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869269001549	non-specific DNA binding site [nucleotide binding]; other site
869269001550	salt bridge; other site
869269001551	sequence-specific DNA binding site [nucleotide binding]; other site
869269001552	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
869269001553	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
869269001554	THF binding site; other site
869269001555	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
869269001556	substrate binding site [chemical binding]; other site
869269001557	THF binding site; other site
869269001558	zinc-binding site [ion binding]; other site
869269001559	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
869269001560	FAD binding site [chemical binding]; other site
869269001561	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
869269001562	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
869269001563	RNase E interface [polypeptide binding]; other site
869269001564	trimer interface [polypeptide binding]; other site
869269001565	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
869269001566	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
869269001567	RNase E interface [polypeptide binding]; other site
869269001568	trimer interface [polypeptide binding]; other site
869269001569	active site
869269001570	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
869269001571	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
869269001572	RNA binding site [nucleotide binding]; other site
869269001573	domain interface; other site
869269001574	serine O-acetyltransferase; Region: cysE; TIGR01172
869269001575	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
869269001576	trimer interface [polypeptide binding]; other site
869269001577	active site
869269001578	substrate binding site [chemical binding]; other site
869269001579	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869269001580	Coenzyme A binding pocket [chemical binding]; other site
869269001581	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
869269001582	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869269001583	Coenzyme A binding pocket [chemical binding]; other site
869269001584	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
869269001585	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
869269001586	active site
869269001587	HIGH motif; other site
869269001588	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
869269001589	KMSKS motif; other site
869269001590	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
869269001591	tRNA binding surface [nucleotide binding]; other site
869269001592	anticodon binding site; other site
869269001593	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
869269001594	active site
869269001595	metal binding site [ion binding]; metal-binding site
869269001596	dimerization interface [polypeptide binding]; other site
869269001597	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
869269001598	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
869269001601	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
869269001602	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
869269001603	FtsX-like permease family; Region: FtsX; pfam02687
869269001604	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
869269001605	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
869269001606	Walker A/P-loop; other site
869269001607	ATP binding site [chemical binding]; other site
869269001608	Q-loop/lid; other site
869269001609	ABC transporter signature motif; other site
869269001610	Walker B; other site
869269001611	D-loop; other site
869269001612	H-loop/switch region; other site
869269001613	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
869269001614	FtsX-like permease family; Region: FtsX; pfam02687
869269001615	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
869269001616	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
869269001617	active site
869269001618	phosphorylation site [posttranslational modification]
869269001619	intermolecular recognition site; other site
869269001620	dimerization interface [polypeptide binding]; other site
869269001621	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
869269001622	DNA binding site [nucleotide binding]
869269001623	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
869269001624	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
869269001625	dimerization interface [polypeptide binding]; other site
869269001626	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
869269001627	dimer interface [polypeptide binding]; other site
869269001628	phosphorylation site [posttranslational modification]
869269001629	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269001630	ATP binding site [chemical binding]; other site
869269001631	Mg2+ binding site [ion binding]; other site
869269001632	G-X-G motif; other site
869269001633	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
869269001634	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
869269001635	intersubunit interface [polypeptide binding]; other site
869269001636	active site
869269001637	zinc binding site [ion binding]; other site
869269001638	Na+ binding site [ion binding]; other site
869269001639	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
869269001640	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
869269001641	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
869269001642	FAD binding pocket [chemical binding]; other site
869269001643	FAD binding motif [chemical binding]; other site
869269001644	phosphate binding motif [ion binding]; other site
869269001645	beta-alpha-beta structure motif; other site
869269001646	NAD binding pocket [chemical binding]; other site
869269001647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269001648	dimer interface [polypeptide binding]; other site
869269001649	conserved gate region; other site
869269001650	putative PBP binding loops; other site
869269001651	ABC-ATPase subunit interface; other site
869269001652	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269001653	dimer interface [polypeptide binding]; other site
869269001654	conserved gate region; other site
869269001655	putative PBP binding loops; other site
869269001656	ABC-ATPase subunit interface; other site
869269001657	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
869269001658	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
869269001659	substrate binding pocket [chemical binding]; other site
869269001660	membrane-bound complex binding site; other site
869269001661	hinge residues; other site
869269001663	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
869269001664	DHH family; Region: DHH; pfam01368
869269001665	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
869269001666	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
869269001667	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
869269001668	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
869269001669	Predicted esterase [General function prediction only]; Region: COG0627
869269001670	S-formylglutathione hydrolase; Region: PLN02442
869269001671	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
869269001672	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
869269001673	FemAB family; Region: FemAB; pfam02388
869269001674	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
869269001675	active site
869269001676	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
869269001677	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
869269001678	GIY-YIG motif/motif A; other site
869269001679	active site
869269001680	catalytic site [active]
869269001681	putative DNA binding site [nucleotide binding]; other site
869269001682	metal binding site [ion binding]; metal-binding site
869269001683	UvrB/uvrC motif; Region: UVR; pfam02151
869269001684	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
869269001685	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
869269001686	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
869269001687	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
869269001688	substrate binding pocket [chemical binding]; other site
869269001689	membrane-bound complex binding site; other site
869269001690	hinge residues; other site
869269001691	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
869269001692	dimer interface [polypeptide binding]; other site
869269001693	FMN binding site [chemical binding]; other site
869269001694	dipeptidase PepV; Reviewed; Region: PRK07318
869269001695	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
869269001696	active site
869269001697	metal binding site [ion binding]; metal-binding site
869269001698	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
869269001699	putative uracil binding site [chemical binding]; other site
869269001700	putative active site [active]
869269001701	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
869269001702	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
869269001703	active site residue [active]
869269001704	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
869269001705	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
869269001706	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
869269001707	putative oligomer interface [polypeptide binding]; other site
869269001708	putative active site [active]
869269001709	metal binding site [ion binding]; metal-binding site
869269001710	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
869269001711	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
869269001712	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
869269001713	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
869269001714	23S rRNA interface [nucleotide binding]; other site
869269001715	L7/L12 interface [polypeptide binding]; other site
869269001716	putative thiostrepton binding site; other site
869269001717	L25 interface [polypeptide binding]; other site
869269001718	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
869269001719	mRNA/rRNA interface [nucleotide binding]; other site
869269001720	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
869269001721	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269001722	Walker A/P-loop; other site
869269001723	ATP binding site [chemical binding]; other site
869269001724	Q-loop/lid; other site
869269001725	ABC transporter signature motif; other site
869269001726	Walker B; other site
869269001727	D-loop; other site
869269001728	H-loop/switch region; other site
869269001729	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
869269001730	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
869269001731	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
869269001732	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
869269001733	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
869269001734	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
869269001735	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
869269001736	putative active site [active]
869269001737	catalytic triad [active]
869269001738	PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819
869269001739	PA/protease or protease-like domain interface [polypeptide binding]; other site
869269001740	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
869269001741	catalytic residues [active]
869269001742	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
869269001743	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
869269001744	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
869269001745	active site
869269001746	phosphorylation site [posttranslational modification]
869269001747	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
869269001748	active site
869269001749	P-loop; other site
869269001750	phosphorylation site [posttranslational modification]
869269001751	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
869269001752	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
869269001753	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
869269001754	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
869269001755	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
869269001756	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
869269001757	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
869269001758	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
869269001759	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
869269001760	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
869269001761	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
869269001762	G5 domain; Region: G5; pfam07501
869269001763	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
869269001764	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
869269001765	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869269001766	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
869269001767	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
869269001769	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
869269001770	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
869269001771	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
869269001772	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
869269001773	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
869269001774	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
869269001775	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
869269001776	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
869269001777	catalytic residues [active]
869269001778	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
869269001779	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
869269001780	SelR domain; Region: SelR; pfam01641
869269001781	Response regulator receiver domain; Region: Response_reg; pfam00072
869269001782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
869269001783	active site
869269001784	phosphorylation site [posttranslational modification]
869269001785	intermolecular recognition site; other site
869269001786	dimerization interface [polypeptide binding]; other site
869269001787	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
869269001788	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869269001789	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
869269001790	Cache domain; Region: Cache_1; pfam02743
869269001791	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
869269001792	dimerization interface [polypeptide binding]; other site
869269001793	Histidine kinase; Region: His_kinase; pfam06580
869269001794	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269001795	ATP binding site [chemical binding]; other site
869269001796	Mg2+ binding site [ion binding]; other site
869269001797	G-X-G motif; other site
869269001798	hypothetical protein; Provisional; Region: PRK13690
869269001799	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
869269001800	G5 domain; Region: G5; pfam07501
869269001801	G5 domain; Region: G5; pfam07501
869269001802	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
869269001803	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
869269001804	aminodeoxychorismate synthase; Provisional; Region: PRK07508
869269001805	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
869269001806	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
869269001807	substrate-cofactor binding pocket; other site
869269001808	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
869269001809	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869269001810	catalytic residue [active]
869269001811	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
869269001812	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
869269001813	Excalibur calcium-binding domain; Region: Excalibur; smart00894
869269001814	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
869269001815	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
869269001816	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
869269001817	nucleotide binding site [chemical binding]; other site
869269001818	thymidylate synthase; Reviewed; Region: thyA; PRK01827
869269001819	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
869269001820	dimerization interface [polypeptide binding]; other site
869269001821	active site
869269001822	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
869269001823	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
869269001824	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
869269001825	GTPases [General function prediction only]; Region: HflX; COG2262
869269001826	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
869269001827	HflX GTPase family; Region: HflX; cd01878
869269001828	G1 box; other site
869269001829	GTP/Mg2+ binding site [chemical binding]; other site
869269001830	Switch I region; other site
869269001831	G2 box; other site
869269001832	G3 box; other site
869269001833	Switch II region; other site
869269001834	G4 box; other site
869269001835	G5 box; other site
869269001836	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
869269001837	ribonuclease Z; Region: RNase_Z; TIGR02651
869269001838	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
869269001839	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869269001840	NAD(P) binding site [chemical binding]; other site
869269001841	active site
869269001842	Transcriptional regulator [Transcription]; Region: LysR; COG0583
869269001843	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
869269001844	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
869269001845	dimerization interface [polypeptide binding]; other site
869269001846	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
869269001847	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
869269001848	active site residue [active]
869269001849	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
869269001850	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
869269001851	RNA binding surface [nucleotide binding]; other site
869269001852	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
869269001853	active site
869269001854	uracil binding [chemical binding]; other site
869269001855	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
869269001856	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
869269001857	G1 box; other site
869269001858	putative GEF interaction site [polypeptide binding]; other site
869269001859	GTP/Mg2+ binding site [chemical binding]; other site
869269001860	Switch I region; other site
869269001861	G2 box; other site
869269001862	G3 box; other site
869269001863	Switch II region; other site
869269001864	G4 box; other site
869269001865	G5 box; other site
869269001866	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
869269001867	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
869269001868	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
869269001869	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683
869269001870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
869269001871	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
869269001872	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269001873	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
869269001874	Walker A/P-loop; other site
869269001875	ATP binding site [chemical binding]; other site
869269001876	Q-loop/lid; other site
869269001877	ABC transporter signature motif; other site
869269001878	Walker B; other site
869269001879	D-loop; other site
869269001880	H-loop/switch region; other site
869269001881	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
869269001882	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
869269001883	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
869269001884	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
869269001885	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
869269001886	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
869269001887	homodimer interface [polypeptide binding]; other site
869269001888	active site
869269001889	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
869269001890	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
869269001891	Cell division protein FtsQ; Region: FtsQ; pfam03799
869269001892	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
869269001893	ThiF family; Region: ThiF; pfam00899
869269001894	ATP binding site [chemical binding]; other site
869269001895	substrate interface [chemical binding]; other site
869269001896	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
869269001897	active site
869269001898	dimer interface [polypeptide binding]; other site
869269001899	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
869269001900	active site
869269001901	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269001902	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
869269001903	Walker A/P-loop; other site
869269001904	ATP binding site [chemical binding]; other site
869269001905	Q-loop/lid; other site
869269001906	ABC transporter signature motif; other site
869269001907	Walker B; other site
869269001908	D-loop; other site
869269001909	H-loop/switch region; other site
869269001912	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269001913	dimer interface [polypeptide binding]; other site
869269001914	conserved gate region; other site
869269001915	putative PBP binding loops; other site
869269001916	ABC-ATPase subunit interface; other site
869269001917	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269001918	dimer interface [polypeptide binding]; other site
869269001919	conserved gate region; other site
869269001920	putative PBP binding loops; other site
869269001921	ABC-ATPase subunit interface; other site
869269001922	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
869269001923	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
869269001924	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
869269001925	dimer interface [polypeptide binding]; other site
869269001926	putative anticodon binding site; other site
869269001927	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
869269001928	motif 1; other site
869269001929	active site
869269001930	motif 2; other site
869269001931	motif 3; other site
869269001932	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
869269001933	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
869269001934	teramer interface [polypeptide binding]; other site
869269001935	active site
869269001936	FMN binding site [chemical binding]; other site
869269001937	catalytic residues [active]
869269001938	Putative transcription activator [Transcription]; Region: TenA; COG0819
869269001939	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
869269001940	substrate binding site [chemical binding]; other site
869269001941	multimerization interface [polypeptide binding]; other site
869269001942	ATP binding site [chemical binding]; other site
869269001943	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
869269001944	thiamine phosphate binding site [chemical binding]; other site
869269001945	active site
869269001946	pyrophosphate binding site [ion binding]; other site
869269001947	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
869269001948	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
869269001949	Walker A/P-loop; other site
869269001950	ATP binding site [chemical binding]; other site
869269001951	ABC transporter; Region: ABC_tran; pfam00005
869269001952	Q-loop/lid; other site
869269001953	ABC transporter signature motif; other site
869269001954	Walker B; other site
869269001955	D-loop; other site
869269001956	H-loop/switch region; other site
869269001957	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269001958	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
869269001959	Walker A/P-loop; other site
869269001960	ATP binding site [chemical binding]; other site
869269001961	Q-loop/lid; other site
869269001962	ABC transporter signature motif; other site
869269001963	Walker B; other site
869269001964	D-loop; other site
869269001965	H-loop/switch region; other site
869269001966	Putative transcription activator [Transcription]; Region: TenA; COG0819
869269001967	Predicted membrane protein [Function unknown]; Region: COG4732
869269001968	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
869269001969	substrate binding site [chemical binding]; other site
869269001970	multimerization interface [polypeptide binding]; other site
869269001971	ATP binding site [chemical binding]; other site
869269001972	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
869269001973	thiamine phosphate binding site [chemical binding]; other site
869269001974	active site
869269001975	pyrophosphate binding site [ion binding]; other site
869269001976	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
869269001977	dimer interface [polypeptide binding]; other site
869269001978	substrate binding site [chemical binding]; other site
869269001979	ATP binding site [chemical binding]; other site
869269001980	Predicted transcriptional regulator [Transcription]; Region: COG3682
869269001981	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
869269001982	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
869269001983	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
869269001984	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
869269001985	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
869269001986	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
869269001987	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
869269001988	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
869269001989	PYR/PP interface [polypeptide binding]; other site
869269001990	dimer interface [polypeptide binding]; other site
869269001991	tetramer interface [polypeptide binding]; other site
869269001992	TPP binding site [chemical binding]; other site
869269001993	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
869269001994	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
869269001995	TPP-binding site [chemical binding]; other site
869269001996	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
869269001997	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
869269001998	active site
869269001999	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
869269002000	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
869269002001	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
869269002003	HI0933-like protein; Region: HI0933_like; pfam03486
869269002004	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
869269002005	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
869269002006	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
869269002007	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
869269002008	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
869269002009	catalytic motif [active]
869269002010	Zn binding site [ion binding]; other site
869269002011	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
869269002012	active site
869269002013	Clp protease; Region: CLP_protease; pfam00574
869269002014	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
869269002015	oligomer interface [polypeptide binding]; other site
869269002016	active site residues [active]
869269002017	hypothetical protein; Provisional; Region: PRK02302
869269002018	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
869269002019	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
869269002020	putative ligand binding site [chemical binding]; other site
869269002021	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
869269002022	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
869269002023	TM-ABC transporter signature motif; other site
869269002024	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
869269002025	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
869269002026	TM-ABC transporter signature motif; other site
869269002027	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
869269002028	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
869269002029	Walker A/P-loop; other site
869269002030	ATP binding site [chemical binding]; other site
869269002031	Q-loop/lid; other site
869269002032	ABC transporter signature motif; other site
869269002033	Walker B; other site
869269002034	D-loop; other site
869269002035	H-loop/switch region; other site
869269002036	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
869269002037	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
869269002038	Walker A/P-loop; other site
869269002039	ATP binding site [chemical binding]; other site
869269002040	Q-loop/lid; other site
869269002041	ABC transporter signature motif; other site
869269002042	Walker B; other site
869269002043	D-loop; other site
869269002044	H-loop/switch region; other site
869269002045	FOG: CBS domain [General function prediction only]; Region: COG0517
869269002046	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
869269002047	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
869269002048	PCRF domain; Region: PCRF; pfam03462
869269002049	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
869269002050	RF-1 domain; Region: RF-1; pfam00472
869269002051	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
869269002052	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269002053	Walker A/P-loop; other site
869269002054	ATP binding site [chemical binding]; other site
869269002055	Q-loop/lid; other site
869269002056	ABC transporter signature motif; other site
869269002057	Walker B; other site
869269002058	D-loop; other site
869269002059	H-loop/switch region; other site
869269002060	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
869269002061	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
869269002062	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269002063	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269002064	Integrase core domain; Region: rve; pfam00665
869269002065	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
869269002066	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
869269002067	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
869269002068	active site turn [active]
869269002069	phosphorylation site [posttranslational modification]
869269002070	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
869269002071	HPr interaction site; other site
869269002072	glycerol kinase (GK) interaction site [polypeptide binding]; other site
869269002073	active site
869269002074	phosphorylation site [posttranslational modification]
869269002075	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
869269002076	putative catalytic site [active]
869269002077	putative metal binding site [ion binding]; other site
869269002078	putative phosphate binding site [ion binding]; other site
869269002079	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
869269002080	DEAD-like helicases superfamily; Region: DEXDc; smart00487
869269002081	ATP binding site [chemical binding]; other site
869269002082	Mg++ binding site [ion binding]; other site
869269002083	motif III; other site
869269002084	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869269002085	nucleotide binding region [chemical binding]; other site
869269002086	ATP-binding site [chemical binding]; other site
869269002087	S-adenosylmethionine synthetase; Validated; Region: PRK05250
869269002088	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
869269002089	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
869269002090	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
869269002091	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
869269002092	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
869269002093	active site
869269002094	FMN binding site [chemical binding]; other site
869269002095	substrate binding site [chemical binding]; other site
869269002096	catalytic residues [active]
869269002097	homodimer interface [polypeptide binding]; other site
869269002098	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
869269002099	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
869269002100	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
869269002101	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
869269002102	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
869269002103	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
869269002104	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
869269002105	FeS/SAM binding site; other site
869269002106	VanZ like family; Region: VanZ; pfam04892
869269002107	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
869269002108	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
869269002109	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
869269002110	ABC transporter; Region: ABC_tran_2; pfam12848
869269002111	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
869269002112	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
869269002113	active site
869269002114	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
869269002115	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
869269002116	KH domain; Region: KH_4; pfam13083
869269002117	G-X-X-G motif; other site
869269002118	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
869269002119	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
869269002120	RimM N-terminal domain; Region: RimM; pfam01782
869269002121	PRC-barrel domain; Region: PRC; pfam05239
869269002122	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
869269002123	ATP cone domain; Region: ATP-cone; pfam03477
869269002124	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
869269002125	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
869269002126	glutathione reductase; Validated; Region: PRK06116
869269002127	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
869269002128	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
869269002129	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
869269002130	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
869269002131	HlyD family secretion protein; Region: HlyD_3; pfam13437
869269002132	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
869269002133	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
869269002134	Walker A/P-loop; other site
869269002135	ATP binding site [chemical binding]; other site
869269002136	Q-loop/lid; other site
869269002137	ABC transporter signature motif; other site
869269002138	Walker B; other site
869269002139	D-loop; other site
869269002140	H-loop/switch region; other site
869269002141	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
869269002142	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
869269002143	FtsX-like permease family; Region: FtsX; pfam02687
869269002144	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
869269002145	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
869269002146	active site
869269002147	HIGH motif; other site
869269002148	KMSKS motif; other site
869269002149	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
869269002150	tRNA binding surface [nucleotide binding]; other site
869269002151	anticodon binding site; other site
869269002152	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
869269002153	dimer interface [polypeptide binding]; other site
869269002154	putative tRNA-binding site [nucleotide binding]; other site
869269002155	Predicted transcriptional regulators [Transcription]; Region: COG1695
869269002156	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
869269002157	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
869269002158	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
869269002159	active site
869269002160	catalytic tetrad [active]
869269002161	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
869269002162	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
869269002163	classical (c) SDRs; Region: SDR_c; cd05233
869269002164	NAD(P) binding site [chemical binding]; other site
869269002165	active site
869269002166	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
869269002167	nudix motif; other site
869269002168	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
869269002169	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
869269002170	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
869269002171	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
869269002172	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
869269002173	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
869269002174	Zn binding site [ion binding]; other site
869269002175	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
869269002176	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
869269002177	active site
869269002178	phosphorylation site [posttranslational modification]
869269002179	intermolecular recognition site; other site
869269002180	dimerization interface [polypeptide binding]; other site
869269002181	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
869269002182	DNA binding site [nucleotide binding]
869269002183	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
869269002184	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
869269002185	dimer interface [polypeptide binding]; other site
869269002186	phosphorylation site [posttranslational modification]
869269002187	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269002188	ATP binding site [chemical binding]; other site
869269002189	Mg2+ binding site [ion binding]; other site
869269002190	G-X-G motif; other site
869269002191	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
869269002192	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
869269002193	Peptidase family U32; Region: Peptidase_U32; pfam01136
869269002194	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
869269002195	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
869269002196	active site
869269002197	catalytic site [active]
869269002198	substrate binding site [chemical binding]; other site
869269002199	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869269002200	ATP binding site [chemical binding]; other site
869269002201	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
869269002202	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
869269002203	DJ-1 family protein; Region: not_thiJ; TIGR01383
869269002204	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
869269002205	conserved cys residue [active]
869269002206	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
869269002207	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269002208	motif II; other site
869269002209	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
869269002210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269002211	Mg2+ binding site [ion binding]; other site
869269002212	G-X-G motif; other site
869269002213	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
869269002214	anchoring element; other site
869269002215	dimer interface [polypeptide binding]; other site
869269002216	ATP binding site [chemical binding]; other site
869269002217	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
869269002218	active site
869269002219	putative metal-binding site [ion binding]; other site
869269002220	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
869269002221	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
869269002222	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
869269002224	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
869269002225	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
869269002226	Walker A motif; other site
869269002227	ATP binding site [chemical binding]; other site
869269002228	Walker B motif; other site
869269002229	arginine finger; other site
869269002230	UvrB/uvrC motif; Region: UVR; pfam02151
869269002231	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
869269002232	Walker A motif; other site
869269002233	ATP binding site [chemical binding]; other site
869269002234	Walker B motif; other site
869269002235	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
869269002236	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
869269002237	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
869269002238	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269002239	dimer interface [polypeptide binding]; other site
869269002240	conserved gate region; other site
869269002241	putative PBP binding loops; other site
869269002242	ABC-ATPase subunit interface; other site
869269002243	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
869269002244	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
869269002245	Walker A/P-loop; other site
869269002246	ATP binding site [chemical binding]; other site
869269002247	Q-loop/lid; other site
869269002248	ABC transporter signature motif; other site
869269002249	Walker B; other site
869269002250	D-loop; other site
869269002251	H-loop/switch region; other site
869269002252	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
869269002253	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
869269002254	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
869269002255	homodimer interface [polypeptide binding]; other site
869269002256	NADP binding site [chemical binding]; other site
869269002257	substrate binding site [chemical binding]; other site
869269002258	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
869269002259	putative substrate binding site [chemical binding]; other site
869269002260	putative ATP binding site [chemical binding]; other site
869269002261	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
869269002262	tetramer (dimer of dimers) interface [polypeptide binding]; other site
869269002263	active site
869269002264	dimer interface [polypeptide binding]; other site
869269002265	phosphopentomutase; Provisional; Region: PRK05362
869269002266	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
869269002267	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
869269002268	purine nucleoside phosphorylase; Provisional; Region: PRK08202
869269002270	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
869269002271	topology modulation protein; Provisional; Region: PRK07261
869269002272	AAA domain; Region: AAA_17; pfam13207
869269002273	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
869269002274	pantothenate kinase; Provisional; Region: PRK05439
869269002275	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
869269002276	ATP-binding site [chemical binding]; other site
869269002277	CoA-binding site [chemical binding]; other site
869269002278	Mg2+-binding site [ion binding]; other site
869269002279	similar to putative membrane protein (pseudogene)
869269002280	Methyltransferase domain; Region: Methyltransf_31; pfam13847
869269002281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269002282	S-adenosylmethionine binding site [chemical binding]; other site
869269002283	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
869269002284	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
869269002285	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
869269002286	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
869269002287	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
869269002288	intersubunit interface [polypeptide binding]; other site
869269002289	active site
869269002290	catalytic residue [active]
869269002291	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
869269002292	active site
869269002293	catalytic motif [active]
869269002294	Zn binding site [ion binding]; other site
869269002295	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
869269002296	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
869269002297	ligand binding site [chemical binding]; other site
869269002298	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
869269002299	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
869269002300	Walker A/P-loop; other site
869269002301	ATP binding site [chemical binding]; other site
869269002302	Q-loop/lid; other site
869269002303	ABC transporter signature motif; other site
869269002304	Walker B; other site
869269002305	D-loop; other site
869269002306	H-loop/switch region; other site
869269002307	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
869269002308	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
869269002309	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
869269002310	TM-ABC transporter signature motif; other site
869269002311	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
869269002312	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
869269002313	TM-ABC transporter signature motif; other site
869269002314	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
869269002315	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
869269002316	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269002317	Mg2+ binding site [ion binding]; other site
869269002318	G-X-G motif; other site
869269002319	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
869269002320	anchoring element; other site
869269002321	dimer interface [polypeptide binding]; other site
869269002322	ATP binding site [chemical binding]; other site
869269002323	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
869269002324	active site
869269002325	putative metal-binding site [ion binding]; other site
869269002326	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
869269002327	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
869269002328	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
869269002329	CAP-like domain; other site
869269002330	active site
869269002331	primary dimer interface [polypeptide binding]; other site
869269002332	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
869269002333	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
869269002334	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
869269002335	homodimer interface [polypeptide binding]; other site
869269002336	substrate-cofactor binding pocket; other site
869269002337	catalytic residue [active]
869269002338	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
869269002339	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
869269002340	Predicted membrane protein [Function unknown]; Region: COG3819
869269002341	Predicted membrane protein [Function unknown]; Region: COG3817
869269002342	Protein of unknown function (DUF979); Region: DUF979; pfam06166
869269002343	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
869269002344	putative substrate binding pocket [chemical binding]; other site
869269002345	AC domain interface; other site
869269002346	catalytic triad [active]
869269002347	AB domain interface; other site
869269002348	interchain disulfide; other site
869269002349	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
869269002350	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
869269002351	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
869269002352	RNA binding site [nucleotide binding]; other site
869269002353	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
869269002354	RNA binding site [nucleotide binding]; other site
869269002355	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
869269002356	RNA binding site [nucleotide binding]; other site
869269002357	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
869269002358	RNA binding site [nucleotide binding]; other site
869269002359	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
869269002360	GAF domain; Region: GAF_2; pfam13185
869269002361	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
869269002362	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
869269002363	Walker A motif; other site
869269002364	ATP binding site [chemical binding]; other site
869269002365	Walker B motif; other site
869269002366	arginine finger; other site
869269002367	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
869269002368	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
869269002369	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
869269002370	Walker A/P-loop; other site
869269002371	ATP binding site [chemical binding]; other site
869269002372	Q-loop/lid; other site
869269002373	ABC transporter signature motif; other site
869269002374	Walker B; other site
869269002375	D-loop; other site
869269002376	H-loop/switch region; other site
869269002377	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
869269002378	FeS assembly protein SufD; Region: sufD; TIGR01981
869269002379	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
869269002380	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
869269002381	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
869269002382	catalytic residue [active]
869269002383	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
869269002384	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
869269002385	trimerization site [polypeptide binding]; other site
869269002386	active site
869269002387	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
869269002388	FeS assembly protein SufB; Region: sufB; TIGR01980
869269002389	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
869269002390	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
869269002391	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
869269002392	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
869269002393	Domain of unknown function DUF20; Region: UPF0118; pfam01594
869269002394	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
869269002395	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
869269002396	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
869269002397	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
869269002398	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
869269002399	putative substrate binding site [chemical binding]; other site
869269002400	putative ATP binding site [chemical binding]; other site
869269002401	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
869269002402	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
869269002403	active site
869269002404	phosphorylation site [posttranslational modification]
869269002405	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
869269002406	active site
869269002407	P-loop; other site
869269002408	phosphorylation site [posttranslational modification]
869269002409	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
869269002410	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
869269002411	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
869269002412	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
869269002413	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
869269002414	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
869269002415	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
869269002416	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
869269002417	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
869269002418	catalytic residue [active]
869269002419	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
869269002420	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
869269002421	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
869269002422	Ligand Binding Site [chemical binding]; other site
869269002423	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
869269002424	Putative esterase; Region: Esterase; pfam00756
869269002425	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
869269002426	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
869269002427	HsdM N-terminal domain; Region: HsdM_N; pfam12161
869269002428	Methyltransferase domain; Region: Methyltransf_26; pfam13659
869269002429	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
869269002430	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
869269002431	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
869269002432	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
869269002433	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
869269002434	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
869269002435	active site
869269002436	catalytic residues [active]
869269002437	DNA binding site [nucleotide binding]
869269002438	Int/Topo IB signature motif; other site
869269002439	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
869269002440	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
869269002441	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
869269002442	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869269002443	ATP binding site [chemical binding]; other site
869269002444	putative Mg++ binding site [ion binding]; other site
869269002445	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
869269002446	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
869269002447	Transposase; Region: DDE_Tnp_ISL3; pfam01610
869269002448	EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463
869269002450	CAAX protease self-immunity; Region: Abi; pfam02517
869269002451	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
869269002452	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
869269002453	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
869269002454	putative active site [active]
869269002455	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
869269002456	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
869269002457	putative active site cavity [active]
869269002458	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
869269002459	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
869269002460	inhibitor site; inhibition site
869269002461	active site
869269002462	dimer interface [polypeptide binding]; other site
869269002463	catalytic residue [active]
869269002464	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
869269002465	Na binding site [ion binding]; other site
869269002466	Domain of unknown function (DUF386); Region: DUF386; pfam04074
869269002467	Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409
869269002468	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
869269002469	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
869269002470	Asp-box motif; other site
869269002471	catalytic site [active]
869269002472	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
869269002473	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
869269002474	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
869269002475	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
869269002476	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
869269002477	Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269
869269002478	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
869269002479	V-type ATP synthase subunit K; Validated; Region: PRK06558
869269002480	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
869269002481	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
869269002482	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
869269002483	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
869269002484	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
869269002485	V-type ATP synthase subunit F; Provisional; Region: PRK01395
869269002486	V-type ATP synthase subunit A; Provisional; Region: PRK04192
869269002487	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
869269002488	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
869269002489	Walker A motif/ATP binding site; other site
869269002490	Walker B motif; other site
869269002491	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
869269002492	V-type ATP synthase subunit B; Provisional; Region: PRK04196
869269002493	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
869269002494	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
869269002495	Walker A motif homologous position; other site
869269002496	Walker B motif; other site
869269002497	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
869269002498	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
869269002499	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
869269002500	Transposase; Region: DDE_Tnp_ISL3; pfam01610
869269002501	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
869269002502	Arginine repressor [Transcription]; Region: ArgR; COG1438
869269002503	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
869269002504	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
869269002505	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
869269002506	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
869269002507	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
869269002508	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
869269002509	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
869269002510	active site
869269002511	PHP Thumb interface [polypeptide binding]; other site
869269002512	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
869269002513	generic binding surface II; other site
869269002514	generic binding surface I; other site
869269002515	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
869269002516	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
869269002517	active site
869269002518	ADP/pyrophosphate binding site [chemical binding]; other site
869269002519	dimerization interface [polypeptide binding]; other site
869269002520	allosteric effector site; other site
869269002521	fructose-1,6-bisphosphate binding site; other site
869269002522	pyruvate kinase; Provisional; Region: PRK05826
869269002523	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
869269002524	domain interfaces; other site
869269002525	active site
869269002527	Domain of unknown function (DUF4300); Region: DUF4300; pfam14133
869269002529	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
869269002530	Predicted membrane protein [Function unknown]; Region: COG3689
869269002531	Predicted permeases [General function prediction only]; Region: COG0701
869269002532	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
869269002533	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
869269002534	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
869269002535	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
869269002536	RNA binding site [nucleotide binding]; other site
869269002537	SprT homologues; Region: SprT; cl01182
869269002538	hypothetical protein; Provisional; Region: PRK04351
869269002539	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
869269002540	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
869269002541	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
869269002542	Walker A/P-loop; other site
869269002543	ATP binding site [chemical binding]; other site
869269002544	Q-loop/lid; other site
869269002545	ABC transporter signature motif; other site
869269002546	Walker B; other site
869269002547	D-loop; other site
869269002548	H-loop/switch region; other site
869269002549	FtsX-like permease family; Region: FtsX; pfam02687
869269002550	disrupted by IS insertion
869269002552	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
869269002553	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
869269002554	homodimer interface [polypeptide binding]; other site
869269002555	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869269002556	catalytic residue [active]
869269002557	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
869269002559	spermidine synthase; Provisional; Region: PRK00811
869269002560	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269002561	S-adenosylmethionine binding site [chemical binding]; other site
869269002562	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
869269002563	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488
869269002564	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
869269002565	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
869269002566	dimer interface [polypeptide binding]; other site
869269002567	active site
869269002568	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
869269002569	catalytic residues [active]
869269002570	substrate binding site [chemical binding]; other site
869269002571	agmatine deiminase; Provisional; Region: PRK13551
869269002572	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
869269002573	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
869269002574	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
869269002575	putative active site; other site
869269002576	catalytic triad [active]
869269002577	putative dimer interface [polypeptide binding]; other site
869269002578	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269002579	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
869269002580	active site
869269002581	motif I; other site
869269002582	motif II; other site
869269002583	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269002584	CAAX protease self-immunity; Region: Abi; pfam02517
869269002585	Transcriptional regulator [Transcription]; Region: LysR; COG0583
869269002586	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
869269002587	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
869269002588	dimerization interface [polypeptide binding]; other site
869269002589	lipoprotein signal peptidase; Provisional; Region: PRK14797
869269002590	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
869269002591	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
869269002592	RNA binding surface [nucleotide binding]; other site
869269002593	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
869269002594	active site
869269002595	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
869269002596	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
869269002597	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
869269002598	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
869269002599	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
869269002600	nucleotide binding site [chemical binding]; other site
869269002601	homotetrameric interface [polypeptide binding]; other site
869269002602	putative phosphate binding site [ion binding]; other site
869269002603	putative allosteric binding site; other site
869269002604	PUA domain; Region: PUA; pfam01472
869269002605	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
869269002606	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
869269002607	putative catalytic cysteine [active]
869269002608	pyrroline-5-carboxylate reductase; Region: PLN02688
869269002609	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
869269002610	thymidylate kinase; Validated; Region: tmk; PRK00698
869269002611	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
869269002612	TMP-binding site; other site
869269002613	ATP-binding site [chemical binding]; other site
869269002614	DNA polymerase III subunit delta'; Validated; Region: PRK07276
869269002615	DNA polymerase III subunit delta'; Validated; Region: PRK08485
869269002616	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
869269002617	Predicted methyltransferases [General function prediction only]; Region: COG0313
869269002618	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
869269002619	putative SAM binding site [chemical binding]; other site
869269002620	putative homodimer interface [polypeptide binding]; other site
869269002621	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
869269002622	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
869269002625	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
869269002626	Glucose inhibited division protein A; Region: GIDA; pfam01134
869269002627	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
869269002628	putative nucleotide binding site [chemical binding]; other site
869269002629	uridine monophosphate binding site [chemical binding]; other site
869269002630	homohexameric interface [polypeptide binding]; other site
869269002631	ribosome recycling factor; Reviewed; Region: frr; PRK00083
869269002632	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
869269002633	hinge region; other site
869269002634	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
869269002635	S1 domain; Region: S1_2; pfam13509
869269002636	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
869269002637	hypothetical protein; Provisional; Region: PRK13672
869269002638	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
869269002639	PhoH-like protein; Region: PhoH; pfam02562
869269002640	similar to putative acetyltransferase (pseudogene)
869269002641	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
869269002642	similar to putative alanine dehydrogenase 1 (pseudogene)
869269002643	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
869269002644	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
869269002645	SLBB domain; Region: SLBB; pfam10531
869269002646	comEA protein; Region: comE; TIGR01259
869269002647	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
869269002648	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
869269002649	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
869269002650	Competence protein; Region: Competence; pfam03772
869269002651	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
869269002652	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
869269002653	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
869269002654	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
869269002655	Walker A/P-loop; other site
869269002656	ATP binding site [chemical binding]; other site
869269002657	Q-loop/lid; other site
869269002658	ABC transporter signature motif; other site
869269002659	Walker B; other site
869269002660	D-loop; other site
869269002661	H-loop/switch region; other site
869269002662	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
869269002663	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
869269002664	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
869269002665	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
869269002666	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
869269002667	23S rRNA binding site [nucleotide binding]; other site
869269002668	L21 binding site [polypeptide binding]; other site
869269002669	L13 binding site [polypeptide binding]; other site
869269002670	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
869269002671	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
869269002672	dimer interface [polypeptide binding]; other site
869269002673	active site
869269002674	metal binding site [ion binding]; metal-binding site
869269002675	glutathione binding site [chemical binding]; other site
869269002676	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
869269002677	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
869269002678	FAD binding pocket [chemical binding]; other site
869269002679	FAD binding motif [chemical binding]; other site
869269002680	phosphate binding motif [ion binding]; other site
869269002681	beta-alpha-beta structure motif; other site
869269002682	NAD binding pocket [chemical binding]; other site
869269002683	Iron coordination center [ion binding]; other site
869269002684	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
869269002685	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
869269002686	heterodimer interface [polypeptide binding]; other site
869269002687	active site
869269002688	FMN binding site [chemical binding]; other site
869269002689	homodimer interface [polypeptide binding]; other site
869269002690	substrate binding site [chemical binding]; other site
869269002691	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
869269002692	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
869269002693	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
869269002694	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
869269002695	Domain of unknown function (DUF814); Region: DUF814; pfam05670
869269002696	metal-binding heat shock protein; Provisional; Region: PRK00016
869269002697	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
869269002698	GTPase Era; Reviewed; Region: era; PRK00089
869269002699	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
869269002700	G1 box; other site
869269002701	GTP/Mg2+ binding site [chemical binding]; other site
869269002702	Switch I region; other site
869269002703	G2 box; other site
869269002704	Switch II region; other site
869269002705	G3 box; other site
869269002706	G4 box; other site
869269002707	G5 box; other site
869269002708	KH domain; Region: KH_2; pfam07650
869269002709	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
869269002710	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
869269002711	DNA binding site [nucleotide binding]
869269002712	catalytic residue [active]
869269002713	H2TH interface [polypeptide binding]; other site
869269002714	putative catalytic residues [active]
869269002715	turnover-facilitating residue; other site
869269002716	intercalation triad [nucleotide binding]; other site
869269002717	8OG recognition residue [nucleotide binding]; other site
869269002718	putative reading head residues; other site
869269002719	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
869269002720	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
869269002721	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
869269002722	dephospho-CoA kinase; Region: TIGR00152
869269002723	CoA-binding site [chemical binding]; other site
869269002724	ATP-binding [chemical binding]; other site
869269002725	drug efflux system protein MdtG; Provisional; Region: PRK09874
869269002726	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
869269002727	putative substrate translocation pore; other site
869269002728	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
869269002729	ribonuclease R; Region: RNase_R; TIGR02063
869269002730	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
869269002731	RNB domain; Region: RNB; pfam00773
869269002732	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
869269002733	RNA binding site [nucleotide binding]; other site
869269002734	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
869269002735	SmpB-tmRNA interface; other site
869269002736	tellurite resistance protein TehB; Provisional; Region: PRK12335
869269002737	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
869269002738	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269002739	S-adenosylmethionine binding site [chemical binding]; other site
869269002740	Competence protein CoiA-like family, contains a predicted nuclease    domain [General function prediction only]; Region: CoiA; COG4469
869269002741	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
869269002742	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
869269002743	active site
869269002744	Zn binding site [ion binding]; other site
869269002745	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
869269002746	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269002747	S-adenosylmethionine binding site [chemical binding]; other site
869269002748	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
869269002749	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
869269002752	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
869269002753	catalytic core [active]
869269002754	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
869269002755	putative deacylase active site [active]
869269002756	Predicted membrane protein [Function unknown]; Region: COG2035
869269002757	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
869269002758	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
869269002759	active site
869269002760	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
869269002761	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
869269002762	Substrate binding site; other site
869269002763	Mg++ binding site; other site
869269002764	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
869269002765	active site
869269002766	substrate binding site [chemical binding]; other site
869269002767	CoA binding site [chemical binding]; other site
869269002768	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
869269002769	dimer interface [polypeptide binding]; other site
869269002770	ADP-ribose binding site [chemical binding]; other site
869269002771	active site
869269002772	nudix motif; other site
869269002773	metal binding site [ion binding]; metal-binding site
869269002774	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
869269002775	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
869269002776	MarR family; Region: MarR_2; cl17246
869269002777	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
869269002778	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
869269002779	active site
869269002780	catalytic site [active]
869269002781	substrate binding site [chemical binding]; other site
869269002782	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
869269002783	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
869269002784	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
869269002785	putative active site [active]
869269002786	catalytic site [active]
869269002787	putative metal binding site [ion binding]; other site
869269002788	Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases; Region: TM_EGFR-like; cl17045
869269002789	dimer interface [polypeptide binding]; other site
869269002790	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
869269002791	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
869269002792	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
869269002793	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
869269002794	catalytic residues [active]
869269002795	amino acid transporter; Region: 2A0306; TIGR00909
869269002796	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
869269002797	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
869269002798	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
869269002799	metal binding site [ion binding]; metal-binding site
869269002800	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
869269002801	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
869269002802	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
869269002803	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
869269002804	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
869269002805	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
869269002806	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
869269002807	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
869269002808	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
869269002811	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
869269002812	peptidase T; Region: peptidase-T; TIGR01882
869269002813	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
869269002814	metal binding site [ion binding]; metal-binding site
869269002815	dimer interface [polypeptide binding]; other site
869269002816	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
869269002817	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
869269002818	Catalytic site [active]
869269002819	T surface-antigen of pili; Region: FctA; cl16948
869269002820	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
869269002821	active site
869269002822	catalytic site [active]
869269002823	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
869269002824	active site
869269002825	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
869269002826	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
869269002827	active site
869269002828	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
869269002829	active site
869269002830	N-terminal domain interface [polypeptide binding]; other site
869269002831	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
869269002832	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
869269002833	Predicted membrane protein [Function unknown]; Region: COG2246
869269002834	GtrA-like protein; Region: GtrA; pfam04138
869269002835	Predicted membrane protein [Function unknown]; Region: COG4708
869269002836	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
869269002837	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
869269002838	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
869269002839	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
869269002840	dimer interface [polypeptide binding]; other site
869269002841	active site
869269002842	catalytic residue [active]
869269002843	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
869269002844	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
869269002845	trmE is a tRNA modification GTPase; Region: trmE; cd04164
869269002846	G1 box; other site
869269002847	GTP/Mg2+ binding site [chemical binding]; other site
869269002848	Switch I region; other site
869269002849	G2 box; other site
869269002850	Switch II region; other site
869269002851	G3 box; other site
869269002852	G4 box; other site
869269002853	G5 box; other site
869269002854	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
869269002855	4-oxalocrotonate tautomerase; Provisional; Region: PRK02289
869269002856	active site 1 [active]
869269002857	dimer interface [polypeptide binding]; other site
869269002858	hexamer interface [polypeptide binding]; other site
869269002859	active site 2 [active]
869269002860	thymidine kinase; Provisional; Region: PRK04296
869269002861	peptide chain release factor 1; Validated; Region: prfA; PRK00591
869269002862	This domain is found in peptide chain release factors; Region: PCRF; smart00937
869269002863	RF-1 domain; Region: RF-1; pfam00472
869269002864	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
869269002865	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269002866	S-adenosylmethionine binding site [chemical binding]; other site
869269002867	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
869269002868	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
869269002869	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869269002870	Coenzyme A binding pocket [chemical binding]; other site
869269002871	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
869269002872	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
869269002873	dimer interface [polypeptide binding]; other site
869269002874	active site
869269002875	glycine-pyridoxal phosphate binding site [chemical binding]; other site
869269002876	folate binding site [chemical binding]; other site
869269002877	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
869269002878	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
869269002879	Lysozyme-like; Region: Lysozyme_like; pfam13702
869269002880	catalytic residue [active]
869269002881	Predicted secreted protein [Function unknown]; Region: COG4086
869269002882	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
869269002883	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
869269002884	TRAM domain; Region: TRAM; cl01282
869269002885	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269002886	S-adenosylmethionine binding site [chemical binding]; other site
869269002887	Predicted transcriptional regulator [Transcription]; Region: COG3655
869269002888	sequence-specific DNA binding site [nucleotide binding]; other site
869269002889	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269002890	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269002891	Integrase core domain; Region: rve; pfam00665
869269002892	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
869269002893	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
869269002894	siderophore binding site; other site
869269002895	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
869269002896	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
869269002897	ABC-ATPase subunit  interface; other site
869269002898	dimer interface [polypeptide binding]; other site
869269002899	putative PBP binding regions; other site
869269002900	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
869269002901	ABC-ATPase subunit  interface; other site
869269002902	dimer interface [polypeptide binding]; other site
869269002903	putative PBP binding regions; other site
869269002904	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
869269002905	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
869269002906	Walker A/P-loop; other site
869269002907	ATP binding site [chemical binding]; other site
869269002908	Q-loop/lid; other site
869269002909	ABC transporter signature motif; other site
869269002910	Walker B; other site
869269002911	D-loop; other site
869269002912	H-loop/switch region; other site
869269002914	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
869269002916	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
869269002917	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
869269002918	catalytic residues [active]
869269002919	Recombinase; Region: Recombinase; pfam07508
869269002920	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
869269002921	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
869269002922	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
869269002923	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
869269002924	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
869269002928	Truncation indicated by alignment with homologues and Frameplot
869269002930	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269002931	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
869269002932	Walker A/P-loop; other site
869269002933	ATP binding site [chemical binding]; other site
869269002934	Q-loop/lid; other site
869269002935	ABC transporter signature motif; other site
869269002936	Walker B; other site
869269002937	D-loop; other site
869269002938	H-loop/switch region; other site
869269002939	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
869269002940	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
869269002941	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869269002942	sequence-specific DNA binding site [nucleotide binding]; other site
869269002943	salt bridge; other site
869269002945	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
869269002946	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
869269002947	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
869269002948	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
869269002949	zinc binding site [ion binding]; other site
869269002950	putative ligand binding site [chemical binding]; other site
869269002951	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
869269002952	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
869269002953	TM-ABC transporter signature motif; other site
869269002954	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
869269002955	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269002956	Walker A/P-loop; other site
869269002957	ATP binding site [chemical binding]; other site
869269002958	Q-loop/lid; other site
869269002959	ABC transporter signature motif; other site
869269002960	Walker B; other site
869269002961	D-loop; other site
869269002962	H-loop/switch region; other site
869269002963	DNA primase; Validated; Region: dnaG; PRK05667
869269002964	CHC2 zinc finger; Region: zf-CHC2; pfam01807
869269002965	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
869269002966	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
869269002967	active site
869269002968	metal binding site [ion binding]; metal-binding site
869269002969	interdomain interaction site; other site
869269002970	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
869269002971	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
869269002972	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
869269002973	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
869269002974	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
869269002975	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
869269002976	DNA binding residues [nucleotide binding]
869269002977	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
869269002978	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
869269002979	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
869269002980	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
869269002981	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
869269002982	putative ADP-binding pocket [chemical binding]; other site
869269002983	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
869269002984	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
869269002985	GTPase CgtA; Reviewed; Region: obgE; PRK12297
869269002986	GTP1/OBG; Region: GTP1_OBG; pfam01018
869269002987	Obg GTPase; Region: Obg; cd01898
869269002988	G1 box; other site
869269002989	GTP/Mg2+ binding site [chemical binding]; other site
869269002990	Switch I region; other site
869269002991	G2 box; other site
869269002992	G3 box; other site
869269002993	Switch II region; other site
869269002994	G4 box; other site
869269002995	G5 box; other site
869269002996	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
869269002997	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
869269002998	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
869269002999	hinge; other site
869269003000	active site
869269003001	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
869269003002	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
869269003003	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
869269003004	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
869269003005	DNA-binding site [nucleotide binding]; DNA binding site
869269003006	DRTGG domain; Region: DRTGG; pfam07085
869269003007	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
869269003008	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
869269003009	active site 2 [active]
869269003010	active site 1 [active]
869269003011	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
869269003012	active site
869269003014	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
869269003015	Part of AAA domain; Region: AAA_19; pfam13245
869269003016	Family description; Region: UvrD_C_2; pfam13538
869269003017	hypothetical protein; Reviewed; Region: PRK00024
869269003018	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
869269003019	MPN+ (JAMM) motif; other site
869269003020	Zinc-binding site [ion binding]; other site
869269003021	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
869269003022	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
869269003023	catalytic triad [active]
869269003024	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
869269003025	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
869269003026	CoA binding domain; Region: CoA_binding; pfam02629
869269003027	Putative amino acid metabolism; Region: DUF1831; pfam08866
869269003028	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
869269003029	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
869269003030	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
869269003031	catalytic residue [active]
869269003032	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
869269003033	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
869269003034	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
869269003035	active site
869269003036	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
869269003037	putative active site [active]
869269003038	putative metal binding residues [ion binding]; other site
869269003039	signature motif; other site
869269003040	putative triphosphate binding site [ion binding]; other site
869269003041	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
869269003042	synthetase active site [active]
869269003043	NTP binding site [chemical binding]; other site
869269003044	metal binding site [ion binding]; metal-binding site
869269003045	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
869269003046	ATP-NAD kinase; Region: NAD_kinase; pfam01513
869269003047	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
869269003048	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
869269003049	RNA binding surface [nucleotide binding]; other site
869269003050	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
869269003051	active site
869269003052	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
869269003053	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
869269003054	hypothetical protein; Validated; Region: PRK00153
869269003056	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269003057	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269003058	Integrase core domain; Region: rve; pfam00665
869269003059	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
869269003060	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
869269003061	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
869269003062	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
869269003063	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
869269003064	active site
869269003065	Riboflavin kinase; Region: Flavokinase; smart00904
869269003066	Uncharacterized conserved protein [Function unknown]; Region: COG1284
869269003067	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
869269003068	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
869269003069	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
869269003070	EDD domain protein, DegV family; Region: DegV; TIGR00762
869269003071	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
869269003072	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
869269003073	IHF dimer interface [polypeptide binding]; other site
869269003074	IHF - DNA interface [nucleotide binding]; other site
869269003075	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
869269003076	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
869269003077	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
869269003078	ABC transporter; Region: ABC_tran_2; pfam12848
869269003079	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
869269003080	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869269003081	non-specific DNA binding site [nucleotide binding]; other site
869269003082	salt bridge; other site
869269003083	sequence-specific DNA binding site [nucleotide binding]; other site
869269003084	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
869269003085	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
869269003086	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
869269003087	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
869269003088	nucleotide binding pocket [chemical binding]; other site
869269003089	K-X-D-G motif; other site
869269003090	catalytic site [active]
869269003091	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
869269003092	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
869269003093	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
869269003094	Dimer interface [polypeptide binding]; other site
869269003095	BRCT sequence motif; other site
869269003096	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227
869269003097	pullulanase, type I; Region: pulA_typeI; TIGR02104
869269003098	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
869269003099	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
869269003100	Ca binding site [ion binding]; other site
869269003101	active site
869269003102	catalytic site [active]
869269003103	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
869269003104	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
869269003105	tetrameric interface [polypeptide binding]; other site
869269003106	activator binding site; other site
869269003107	NADP binding site [chemical binding]; other site
869269003108	substrate binding site [chemical binding]; other site
869269003109	catalytic residues [active]
869269003110	glycogen branching enzyme; Provisional; Region: PRK12313
869269003111	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
869269003112	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
869269003113	active site
869269003114	catalytic site [active]
869269003115	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
869269003116	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
869269003117	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
869269003118	ligand binding site; other site
869269003119	oligomer interface; other site
869269003120	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
869269003121	dimer interface [polypeptide binding]; other site
869269003122	N-terminal domain interface [polypeptide binding]; other site
869269003123	sulfate 1 binding site; other site
869269003124	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
869269003125	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
869269003126	active site
869269003127	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
869269003128	dimer interface [polypeptide binding]; other site
869269003129	N-terminal domain interface [polypeptide binding]; other site
869269003130	sulfate 1 binding site; other site
869269003131	glycogen synthase; Provisional; Region: glgA; PRK00654
869269003132	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
869269003133	ADP-binding pocket [chemical binding]; other site
869269003134	homodimer interface [polypeptide binding]; other site
869269003135	phosphoserine phosphatase SerB; Region: serB; TIGR00338
869269003136	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269003137	motif II; other site
869269003138	Uncharacterized conserved protein [Function unknown]; Region: COG5506
869269003139	enolase; Provisional; Region: eno; PRK00077
869269003140	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
869269003141	dimer interface [polypeptide binding]; other site
869269003142	metal binding site [ion binding]; metal-binding site
869269003143	substrate binding pocket [chemical binding]; other site
869269003144	Likely prophage remnant
869269003145	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
869269003146	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
869269003147	Int/Topo IB signature motif; other site
869269003148	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
869269003149	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869269003150	non-specific DNA binding site [nucleotide binding]; other site
869269003151	salt bridge; other site
869269003152	sequence-specific DNA binding site [nucleotide binding]; other site
869269003153	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
869269003154	non-specific DNA binding site [nucleotide binding]; other site
869269003155	salt bridge; other site
869269003156	sequence-specific DNA binding site [nucleotide binding]; other site
869269003157	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
869269003158	DNA binding residues [nucleotide binding]
869269003159	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
869269003160	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
869269003161	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
869269003162	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
869269003164	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
869269003165	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
869269003166	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
869269003167	Part of AAA domain; Region: AAA_19; pfam13245
869269003168	Family description; Region: UvrD_C_2; pfam13538
869269003169	Family description; Region: UvrD_C_2; pfam13538
869269003170	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
869269003171	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
869269003172	G5 domain; Region: G5; pfam07501
869269003173	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
869269003174	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
869269003175	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
869269003176	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
869269003177	GTP/Mg2+ binding site [chemical binding]; other site
869269003178	G4 box; other site
869269003179	G5 box; other site
869269003180	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
869269003181	G1 box; other site
869269003182	G1 box; other site
869269003183	GTP/Mg2+ binding site [chemical binding]; other site
869269003184	Switch I region; other site
869269003185	G2 box; other site
869269003186	G2 box; other site
869269003187	G3 box; other site
869269003188	G3 box; other site
869269003189	Switch II region; other site
869269003190	Switch II region; other site
869269003191	G5 box; other site
869269003192	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
869269003193	RNA/DNA hybrid binding site [nucleotide binding]; other site
869269003194	active site
869269003195	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
869269003196	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
869269003197	Cl- selectivity filter; other site
869269003198	Cl- binding residues [ion binding]; other site
869269003199	pore gating glutamate residue; other site
869269003200	dimer interface [polypeptide binding]; other site
869269003201	H+/Cl- coupling transport residue; other site
869269003202	TrkA-C domain; Region: TrkA_C; pfam02080
869269003203	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
869269003204	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
869269003205	active site
869269003206	DNA binding site [nucleotide binding]
869269003207	Int/Topo IB signature motif; other site
869269003208	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
869269003209	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
869269003210	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
869269003211	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
869269003212	E3 interaction surface; other site
869269003213	lipoyl attachment site [posttranslational modification]; other site
869269003214	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
869269003215	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
869269003216	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
869269003217	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
869269003218	dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843
869269003219	e3 binding domain; Region: E3_binding; pfam02817
869269003220	e3 binding domain; Region: E3_binding; pfam02817
869269003221	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
869269003222	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
869269003223	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
869269003224	alpha subunit interface [polypeptide binding]; other site
869269003225	TPP binding site [chemical binding]; other site
869269003226	heterodimer interface [polypeptide binding]; other site
869269003227	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
869269003228	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
869269003229	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
869269003230	tetramer interface [polypeptide binding]; other site
869269003231	TPP-binding site [chemical binding]; other site
869269003232	heterodimer interface [polypeptide binding]; other site
869269003233	phosphorylation loop region [posttranslational modification]
869269003234	multidrug efflux protein; Reviewed; Region: PRK01766
869269003235	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
869269003236	cation binding site [ion binding]; other site
869269003237	dihydroorotase; Validated; Region: pyrC; PRK09357
869269003238	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
869269003239	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
869269003240	active site
869269003241	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
869269003242	putative active site [active]
869269003243	nucleotide binding site [chemical binding]; other site
869269003244	nudix motif; other site
869269003245	putative metal binding site [ion binding]; other site
869269003246	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
869269003247	ligand binding site [chemical binding]; other site
869269003248	active site
869269003249	UGI interface [polypeptide binding]; other site
869269003250	catalytic site [active]
869269003251	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
869269003252	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269003253	motif II; other site
869269003254	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
869269003255	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
869269003256	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
869269003257	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
869269003258	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
869269003259	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
869269003260	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
869269003261	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
869269003262	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
869269003263	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
869269003264	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
869269003265	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
869269003266	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
869269003267	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
869269003268	dimerization domain swap beta strand [polypeptide binding]; other site
869269003269	regulatory protein interface [polypeptide binding]; other site
869269003270	active site
869269003271	regulatory phosphorylation site [posttranslational modification]; other site
869269003272	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
869269003273	catalytic residues [active]
869269003274	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
869269003275	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
869269003276	Class I ribonucleotide reductase; Region: RNR_I; cd01679
869269003277	active site
869269003278	dimer interface [polypeptide binding]; other site
869269003279	catalytic residues [active]
869269003280	effector binding site; other site
869269003281	R2 peptide binding site; other site
869269003282	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
869269003283	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
869269003284	dimer interface [polypeptide binding]; other site
869269003285	putative radical transfer pathway; other site
869269003286	diiron center [ion binding]; other site
869269003287	tyrosyl radical; other site
869269003288	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
869269003289	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
869269003290	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
869269003291	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
869269003292	beta-galactosidase; Region: BGL; TIGR03356
869269003293	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
869269003294	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
869269003295	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
869269003296	active site
869269003297	P-loop; other site
869269003298	phosphorylation site [posttranslational modification]
869269003299	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
869269003300	methionine cluster; other site
869269003301	active site
869269003302	phosphorylation site [posttranslational modification]
869269003303	metal binding site [ion binding]; metal-binding site
869269003304	CAT RNA binding domain; Region: CAT_RBD; smart01061
869269003305	transcriptional antiterminator BglG; Provisional; Region: PRK09772
869269003306	PRD domain; Region: PRD; pfam00874
869269003307	PRD domain; Region: PRD; pfam00874
869269003308	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
869269003309	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
869269003310	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
869269003311	putative substrate binding site [chemical binding]; other site
869269003312	putative ATP binding site [chemical binding]; other site
869269003313	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
869269003314	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
869269003315	N-terminal truncation due to IS insertion
869269003317	C-terminal truncation due to IS insertion
869269003318	GTP-binding protein LepA; Provisional; Region: PRK05433
869269003319	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
869269003320	G1 box; other site
869269003321	putative GEF interaction site [polypeptide binding]; other site
869269003322	GTP/Mg2+ binding site [chemical binding]; other site
869269003323	Switch I region; other site
869269003324	G2 box; other site
869269003325	G3 box; other site
869269003326	Switch II region; other site
869269003327	G4 box; other site
869269003328	G5 box; other site
869269003329	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
869269003330	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
869269003331	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
869269003332	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
869269003333	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
869269003334	active site
869269003335	metal binding site [ion binding]; metal-binding site
869269003336	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
869269003337	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
869269003338	Walker A/P-loop; other site
869269003339	ATP binding site [chemical binding]; other site
869269003340	Q-loop/lid; other site
869269003341	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
869269003342	ABC transporter signature motif; other site
869269003343	Walker B; other site
869269003344	D-loop; other site
869269003345	H-loop/switch region; other site
869269003346	Arginine repressor [Transcription]; Region: ArgR; COG1438
869269003347	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
869269003348	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
869269003349	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
869269003350	S4 RNA-binding domain; Region: S4; smart00363
869269003351	RNA binding surface [nucleotide binding]; other site
869269003352	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
869269003353	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
869269003354	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
869269003355	substrate binding pocket [chemical binding]; other site
869269003356	chain length determination region; other site
869269003357	substrate-Mg2+ binding site; other site
869269003358	catalytic residues [active]
869269003359	aspartate-rich region 1; other site
869269003360	active site lid residues [active]
869269003361	aspartate-rich region 2; other site
869269003362	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
869269003363	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
869269003364	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
869269003365	generic binding surface II; other site
869269003366	generic binding surface I; other site
869269003367	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
869269003368	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
869269003369	Sugar specificity; other site
869269003370	Pyrimidine base specificity; other site
869269003371	ATP-binding site [chemical binding]; other site
869269003372	Enterocin A Immunity; Region: EntA_Immun; pfam08951
869269003373	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
869269003374	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
869269003375	RNA binding site [nucleotide binding]; other site
869269003376	active site
869269003377	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
869269003378	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
869269003379	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
869269003381	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
869269003382	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
869269003383	active site
869269003384	catalytic site [active]
869269003385	DNA gyrase subunit A; Validated; Region: PRK05560
869269003386	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
869269003387	CAP-like domain; other site
869269003388	active site
869269003389	primary dimer interface [polypeptide binding]; other site
869269003390	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
869269003391	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
869269003392	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
869269003393	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
869269003394	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
869269003395	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
869269003396	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
869269003397	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
869269003398	tetramer (dimer of dimers) interface [polypeptide binding]; other site
869269003399	NAD binding site [chemical binding]; other site
869269003400	dimer interface [polypeptide binding]; other site
869269003401	substrate binding site [chemical binding]; other site
869269003402	Ion channel; Region: Ion_trans_2; pfam07885
869269003403	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
869269003404	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
869269003405	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
869269003406	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
869269003407	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
869269003408	putative active site [active]
869269003409	heme pocket [chemical binding]; other site
869269003410	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
869269003411	dimer interface [polypeptide binding]; other site
869269003412	phosphorylation site [posttranslational modification]
869269003413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269003414	ATP binding site [chemical binding]; other site
869269003415	Mg2+ binding site [ion binding]; other site
869269003416	G-X-G motif; other site
869269003417	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
869269003418	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
869269003419	active site
869269003420	phosphorylation site [posttranslational modification]
869269003421	intermolecular recognition site; other site
869269003422	dimerization interface [polypeptide binding]; other site
869269003423	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
869269003424	DNA binding site [nucleotide binding]
869269003425	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
869269003426	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
869269003427	minor groove reading motif; other site
869269003428	helix-hairpin-helix signature motif; other site
869269003429	substrate binding pocket [chemical binding]; other site
869269003430	active site
869269003431	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
869269003432	DNA binding and oxoG recognition site [nucleotide binding]
869269003433	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
869269003434	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
869269003435	Potassium binding sites [ion binding]; other site
869269003436	Cesium cation binding sites [ion binding]; other site
869269003437	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
869269003438	phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113
869269003439	Flavoprotein; Region: Flavoprotein; pfam02441
869269003440	Predicted membrane protein [Function unknown]; Region: COG4684
869269003441	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
869269003442	HTH domain; Region: HTH_11; pfam08279
869269003443	3H domain; Region: 3H; pfam02829
869269003444	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
869269003445	putative active site [active]
869269003446	nucleotide binding site [chemical binding]; other site
869269003447	nudix motif; other site
869269003448	putative metal binding site [ion binding]; other site
869269003449	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
869269003450	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869269003451	Coenzyme A binding pocket [chemical binding]; other site
869269003452	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
869269003453	excinuclease ABC subunit B; Provisional; Region: PRK05298
869269003454	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869269003455	ATP binding site [chemical binding]; other site
869269003456	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869269003457	nucleotide binding region [chemical binding]; other site
869269003458	ATP-binding site [chemical binding]; other site
869269003459	Ultra-violet resistance protein B; Region: UvrB; pfam12344
869269003460	UvrB/uvrC motif; Region: UVR; pfam02151
869269003461	CAAX protease self-immunity; Region: Abi; pfam02517
869269003462	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
869269003463	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
869269003464	substrate binding pocket [chemical binding]; other site
869269003465	membrane-bound complex binding site; other site
869269003466	hinge residues; other site
869269003467	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
869269003468	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
869269003469	substrate binding pocket [chemical binding]; other site
869269003470	membrane-bound complex binding site; other site
869269003471	hinge residues; other site
869269003472	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269003473	dimer interface [polypeptide binding]; other site
869269003474	conserved gate region; other site
869269003475	putative PBP binding loops; other site
869269003476	ABC-ATPase subunit interface; other site
869269003477	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
869269003478	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
869269003479	Walker A/P-loop; other site
869269003480	ATP binding site [chemical binding]; other site
869269003481	Q-loop/lid; other site
869269003482	ABC transporter signature motif; other site
869269003483	Walker B; other site
869269003484	D-loop; other site
869269003485	H-loop/switch region; other site
869269003486	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
869269003487	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
869269003488	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
869269003489	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
869269003490	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
869269003491	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
869269003492	P loop; other site
869269003493	GTP binding site [chemical binding]; other site
869269003494	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
869269003495	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269003496	motif II; other site
869269003497	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
869269003498	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
869269003499	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269003500	active site
869269003501	motif I; other site
869269003502	motif II; other site
869269003503	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
869269003504	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
869269003505	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
869269003506	Walker A/P-loop; other site
869269003507	ATP binding site [chemical binding]; other site
869269003508	Q-loop/lid; other site
869269003509	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
869269003510	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
869269003511	ABC transporter signature motif; other site
869269003512	Walker B; other site
869269003513	D-loop; other site
869269003514	H-loop/switch region; other site
869269003515	ribonuclease III; Reviewed; Region: rnc; PRK00102
869269003516	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
869269003517	dimerization interface [polypeptide binding]; other site
869269003518	active site
869269003519	metal binding site [ion binding]; metal-binding site
869269003520	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
869269003521	dsRNA binding site [nucleotide binding]; other site
869269003522	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
869269003523	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
869269003524	active site
869269003525	McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268
869269003526	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
869269003527	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
869269003528	Walker A motif; other site
869269003529	ATP binding site [chemical binding]; other site
869269003530	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
869269003532	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
869269003533	substrate binding site [chemical binding]; other site
869269003534	Predicted membrane protein [Function unknown]; Region: COG3326
869269003535	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
869269003536	tartrate dehydrogenase; Region: TTC; TIGR02089
869269003538	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
869269003539	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
869269003540	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
869269003541	DNA topoisomerase I; Validated; Region: PRK05582
869269003542	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
869269003543	active site
869269003544	interdomain interaction site; other site
869269003545	putative metal-binding site [ion binding]; other site
869269003546	nucleotide binding site [chemical binding]; other site
869269003547	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
869269003548	domain I; other site
869269003549	DNA binding groove [nucleotide binding]
869269003550	phosphate binding site [ion binding]; other site
869269003551	domain II; other site
869269003552	domain III; other site
869269003553	nucleotide binding site [chemical binding]; other site
869269003554	catalytic site [active]
869269003555	domain IV; other site
869269003556	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
869269003557	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
869269003558	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
869269003559	Predicted membrane protein [Function unknown]; Region: COG1808
869269003560	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
869269003561	DNA protecting protein DprA; Region: dprA; TIGR00732
869269003562	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
869269003563	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
869269003564	active site
869269003565	metal-binding site
869269003566	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
869269003567	Phosphotransferase enzyme family; Region: APH; pfam01636
869269003568	active site
869269003569	substrate binding site [chemical binding]; other site
869269003570	ATP binding site [chemical binding]; other site
869269003571	dimer interface [polypeptide binding]; other site
869269003572	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
869269003573	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
869269003574	putative NAD(P) binding site [chemical binding]; other site
869269003575	putative catalytic Zn binding site [ion binding]; other site
869269003576	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
869269003577	substrate binding site; other site
869269003578	dimer interface; other site
869269003579	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
869269003580	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
869269003581	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
869269003582	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
869269003583	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
869269003584	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
869269003585	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
869269003586	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
869269003587	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
869269003588	ATP-grasp domain; Region: ATP-grasp_4; cl17255
869269003589	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
869269003590	IMP binding site; other site
869269003591	dimer interface [polypeptide binding]; other site
869269003592	interdomain contacts; other site
869269003593	partial ornithine binding site; other site
869269003594	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
869269003595	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
869269003596	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
869269003597	catalytic site [active]
869269003598	subunit interface [polypeptide binding]; other site
869269003599	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
869269003600	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
869269003601	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
869269003602	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
869269003603	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
869269003604	active site
869269003605	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
869269003606	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
869269003607	minor groove reading motif; other site
869269003608	helix-hairpin-helix signature motif; other site
869269003609	substrate binding pocket [chemical binding]; other site
869269003610	active site
869269003611	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
869269003613	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
869269003614	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
869269003615	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
869269003616	heat shock protein HtpX; Provisional; Region: PRK04897
869269003617	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
869269003618	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
869269003619	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269003620	S-adenosylmethionine binding site [chemical binding]; other site
869269003621	uracil transporter; Provisional; Region: PRK10720
869269003622	signal recognition particle protein; Provisional; Region: PRK10867
869269003623	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
869269003624	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
869269003625	P loop; other site
869269003626	GTP binding site [chemical binding]; other site
869269003627	Signal peptide binding domain; Region: SRP_SPB; pfam02978
869269003628	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
869269003629	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
869269003630	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
869269003631	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
869269003632	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
869269003633	Zn2+ binding site [ion binding]; other site
869269003634	Mg2+ binding site [ion binding]; other site
869269003635	sugar phosphate phosphatase; Provisional; Region: PRK10513
869269003636	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269003637	active site
869269003638	motif I; other site
869269003639	motif II; other site
869269003640	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269003641	SAP domain; Region: SAP; pfam02037
869269003642	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
869269003643	camphor resistance protein CrcB; Provisional; Region: PRK14229
869269003644	camphor resistance protein CrcB; Provisional; Region: PRK14221
869269003645	hypothetical protein; Provisional; Region: PRK07248
869269003646	flavodoxin; Validated; Region: PRK07308
869269003647	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
869269003648	DHH family; Region: DHH; pfam01368
869269003649	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
869269003651	glutamate dehydrogenase; Provisional; Region: PRK09414
869269003652	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
869269003653	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
869269003654	NAD(P) binding site [chemical binding]; other site
869269003657	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
869269003658	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
869269003659	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
869269003660	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269003661	dimer interface [polypeptide binding]; other site
869269003662	conserved gate region; other site
869269003663	putative PBP binding loops; other site
869269003664	ABC-ATPase subunit interface; other site
869269003665	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
869269003666	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269003667	dimer interface [polypeptide binding]; other site
869269003668	conserved gate region; other site
869269003669	ABC-ATPase subunit interface; other site
869269003670	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
869269003671	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
869269003672	putative active site cavity [active]
869269003673	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
869269003674	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
869269003675	putative active site [active]
869269003676	putative transposase OrfB; Reviewed; Region: PHA02517
869269003677	HTH-like domain; Region: HTH_21; pfam13276
869269003678	Integrase core domain; Region: rve; pfam00665
869269003679	Integrase core domain; Region: rve_2; pfam13333
869269003681	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
869269003682	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
869269003683	Walker A/P-loop; other site
869269003684	ATP binding site [chemical binding]; other site
869269003685	Q-loop/lid; other site
869269003686	ABC transporter signature motif; other site
869269003687	Walker B; other site
869269003688	D-loop; other site
869269003689	H-loop/switch region; other site
869269003690	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
869269003691	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
869269003692	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
869269003693	Walker A/P-loop; other site
869269003694	ATP binding site [chemical binding]; other site
869269003695	Q-loop/lid; other site
869269003696	ABC transporter signature motif; other site
869269003697	Walker B; other site
869269003698	D-loop; other site
869269003699	H-loop/switch region; other site
869269003700	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
869269003701	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
869269003702	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
869269003703	active site
869269003704	ATP binding site [chemical binding]; other site
869269003705	Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791
869269003706	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
869269003707	active site
869269003708	zinc binding site [ion binding]; other site
869269003709	CAAX protease self-immunity; Region: Abi; pfam02517
869269003711	Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393
869269003712	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
869269003713	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
869269003714	core dimer interface [polypeptide binding]; other site
869269003715	L10 interface [polypeptide binding]; other site
869269003716	L11 interface [polypeptide binding]; other site
869269003717	putative EF-Tu interaction site [polypeptide binding]; other site
869269003718	putative EF-G interaction site [polypeptide binding]; other site
869269003719	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
869269003720	23S rRNA interface [nucleotide binding]; other site
869269003721	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
869269003722	chlorohydrolase; Validated; Region: PRK06687
869269003723	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
869269003724	active site
869269003725	putative substrate binding pocket [chemical binding]; other site
869269003726	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
869269003727	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
869269003728	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
869269003729	Walker A/P-loop; other site
869269003730	ATP binding site [chemical binding]; other site
869269003731	Q-loop/lid; other site
869269003732	ABC transporter signature motif; other site
869269003733	Walker B; other site
869269003734	D-loop; other site
869269003735	H-loop/switch region; other site
869269003736	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
869269003737	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
869269003738	APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination; Region: APC10-like; cl02148
869269003739	putative ligand binding site [chemical binding]; other site
869269003740	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269003741	Walker A/P-loop; other site
869269003742	ATP binding site [chemical binding]; other site
869269003743	Q-loop/lid; other site
869269003744	ABC transporter signature motif; other site
869269003745	Walker B; other site
869269003746	D-loop; other site
869269003747	H-loop/switch region; other site
869269003748	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
869269003749	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
869269003750	SelR domain; Region: SelR; pfam01641
869269003751	homoserine kinase; Provisional; Region: PRK01212
869269003752	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
869269003753	homoserine dehydrogenase; Provisional; Region: PRK06349
869269003754	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
869269003755	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
869269003756	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
869269003757	adaptor protein; Provisional; Region: PRK02315
869269003758	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
869269003759	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
869269003760	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
869269003761	active site
869269003762	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
869269003763	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
869269003764	putative ADP-binding pocket [chemical binding]; other site
869269003765	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
869269003766	Transcriptional regulator [Transcription]; Region: LytR; COG1316
869269003767	prephenate dehydratase; Provisional; Region: PRK11898
869269003768	Prephenate dehydratase; Region: PDT; pfam00800
869269003769	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
869269003770	putative L-Phe binding site [chemical binding]; other site
869269003771	shikimate kinase; Reviewed; Region: aroK; PRK00131
869269003772	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
869269003773	ADP binding site [chemical binding]; other site
869269003774	magnesium binding site [ion binding]; other site
869269003775	putative shikimate binding site; other site
869269003776	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
869269003777	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
869269003778	hinge; other site
869269003779	active site
869269003780	hypothetical protein; Provisional; Region: PRK13676
869269003781	prephenate dehydrogenase; Validated; Region: PRK06545
869269003782	prephenate dehydrogenase; Validated; Region: PRK08507
869269003783	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
869269003784	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
869269003785	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
869269003786	Tetramer interface [polypeptide binding]; other site
869269003787	active site
869269003788	FMN-binding site [chemical binding]; other site
869269003789	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
869269003790	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
869269003791	active site
869269003792	dimer interface [polypeptide binding]; other site
869269003793	metal binding site [ion binding]; metal-binding site
869269003794	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
869269003795	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
869269003796	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
869269003797	shikimate binding site; other site
869269003798	NAD(P) binding site [chemical binding]; other site
869269003799	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
869269003800	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
869269003801	active site
869269003802	catalytic residue [active]
869269003803	dimer interface [polypeptide binding]; other site
869269003804	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
869269003805	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
869269003806	putative RNA binding site [nucleotide binding]; other site
869269003807	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269003809	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
869269003810	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
869269003811	Walker A/P-loop; other site
869269003812	ATP binding site [chemical binding]; other site
869269003813	Q-loop/lid; other site
869269003814	ABC transporter signature motif; other site
869269003815	Walker B; other site
869269003816	D-loop; other site
869269003817	H-loop/switch region; other site
869269003818	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
869269003819	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
869269003820	active site
869269003821	Na/Ca binding site [ion binding]; other site
869269003822	catalytic site [active]
869269003823	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
869269003824	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
869269003825	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
869269003826	motif 1; other site
869269003827	active site
869269003828	motif 2; other site
869269003829	motif 3; other site
869269003830	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
869269003831	DHHA1 domain; Region: DHHA1; pfam02272
869269003832	Uncharacterized conserved protein [Function unknown]; Region: COG4894
869269003833	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
869269003834	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
869269003835	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
869269003836	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269003837	dimer interface [polypeptide binding]; other site
869269003838	conserved gate region; other site
869269003839	putative PBP binding loops; other site
869269003840	ABC-ATPase subunit interface; other site
869269003841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269003842	dimer interface [polypeptide binding]; other site
869269003843	conserved gate region; other site
869269003844	putative PBP binding loops; other site
869269003845	ABC-ATPase subunit interface; other site
869269003846	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
869269003847	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
869269003848	Walker A/P-loop; other site
869269003849	ATP binding site [chemical binding]; other site
869269003850	Q-loop/lid; other site
869269003851	ABC transporter signature motif; other site
869269003852	Walker B; other site
869269003853	D-loop; other site
869269003854	H-loop/switch region; other site
869269003855	TOBE domain; Region: TOBE_2; pfam08402
869269003856	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
869269003857	FAD binding domain; Region: FAD_binding_4; pfam01565
869269003858	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
869269003859	Predicted membrane protein [Function unknown]; Region: COG4377
869269003860	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
869269003861	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
869269003862	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
869269003863	DNA-binding site [nucleotide binding]; DNA binding site
869269003864	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
869269003865	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869269003866	homodimer interface [polypeptide binding]; other site
869269003867	catalytic residue [active]
869269003868	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
869269003869	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
869269003870	substrate binding pocket [chemical binding]; other site
869269003871	membrane-bound complex binding site; other site
869269003872	hinge residues; other site
869269003873	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
869269003874	PhoU domain; Region: PhoU; pfam01895
869269003875	PhoU domain; Region: PhoU; pfam01895
869269003876	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
869269003877	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
869269003878	Walker A/P-loop; other site
869269003879	ATP binding site [chemical binding]; other site
869269003880	Q-loop/lid; other site
869269003881	ABC transporter signature motif; other site
869269003882	Walker B; other site
869269003883	D-loop; other site
869269003884	H-loop/switch region; other site
869269003885	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
869269003886	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
869269003887	Walker A/P-loop; other site
869269003888	ATP binding site [chemical binding]; other site
869269003889	Q-loop/lid; other site
869269003890	ABC transporter signature motif; other site
869269003891	Walker B; other site
869269003892	D-loop; other site
869269003893	H-loop/switch region; other site
869269003894	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
869269003895	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269003896	dimer interface [polypeptide binding]; other site
869269003897	conserved gate region; other site
869269003898	putative PBP binding loops; other site
869269003899	ABC-ATPase subunit interface; other site
869269003900	sulfate transport protein; Provisional; Region: cysT; CHL00187
869269003901	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269003902	dimer interface [polypeptide binding]; other site
869269003903	conserved gate region; other site
869269003904	putative PBP binding loops; other site
869269003905	ABC-ATPase subunit interface; other site
869269003906	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
869269003907	phosphate binding protein; Region: ptsS_2; TIGR02136
869269003908	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
869269003909	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269003910	S-adenosylmethionine binding site [chemical binding]; other site
869269003911	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
869269003912	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
869269003913	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
869269003914	active site
869269003915	Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484
869269003916	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
869269003917	ArsC family; Region: ArsC; pfam03960
869269003918	putative catalytic residues [active]
869269003919	thiol/disulfide switch; other site
869269003920	Predicted membrane protein [Function unknown]; Region: COG4478
869269003921	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
869269003922	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269003923	active site
869269003924	motif I; other site
869269003925	motif II; other site
869269003926	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269003927	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
869269003928	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
869269003929	active site
869269003930	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
869269003931	active site
869269003932	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
869269003933	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
869269003934	FeS/SAM binding site; other site
869269003935	HemN C-terminal domain; Region: HemN_C; pfam06969
869269003936	YtxH-like protein; Region: YtxH; pfam12732
869269003937	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
869269003938	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
869269003939	HPr kinase/phosphorylase; Provisional; Region: PRK05428
869269003940	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
869269003941	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
869269003942	Hpr binding site; other site
869269003943	active site
869269003944	homohexamer subunit interaction site [polypeptide binding]; other site
869269003945	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
869269003946	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
869269003947	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
869269003948	active site
869269003949	trimer interface [polypeptide binding]; other site
869269003950	allosteric site; other site
869269003951	active site lid [active]
869269003952	hexamer (dimer of trimers) interface [polypeptide binding]; other site
869269003953	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
869269003954	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
869269003956	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
869269003957	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
869269003958	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
869269003959	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
869269003960	homodimer interface [polypeptide binding]; other site
869269003961	NAD binding pocket [chemical binding]; other site
869269003962	ATP binding pocket [chemical binding]; other site
869269003963	Mg binding site [ion binding]; other site
869269003964	active-site loop [active]
869269003965	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
869269003966	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
869269003967	active site
869269003968	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869269003969	non-specific DNA binding site [nucleotide binding]; other site
869269003970	salt bridge; other site
869269003971	sequence-specific DNA binding site [nucleotide binding]; other site
869269003973	similar to putative ABC transporter ATP-binding protein (pseudogene)
869269003974	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
869269003975	Peptidase family U32; Region: Peptidase_U32; pfam01136
869269003976	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
869269003977	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
869269003978	Peptidase family U32; Region: Peptidase_U32; pfam01136
869269003979	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
869269003981	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
869269003982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269003983	S-adenosylmethionine binding site [chemical binding]; other site
869269003984	Helix-turn-helix domain; Region: HTH_18; pfam12833
869269003985	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869269003986	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
869269003987	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
869269003988	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269003989	Walker A/P-loop; other site
869269003990	ATP binding site [chemical binding]; other site
869269003991	Q-loop/lid; other site
869269003992	ABC transporter signature motif; other site
869269003993	Walker B; other site
869269003994	D-loop; other site
869269003995	H-loop/switch region; other site
869269003996	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
869269003997	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269003998	Walker A/P-loop; other site
869269003999	ATP binding site [chemical binding]; other site
869269004000	Q-loop/lid; other site
869269004001	ABC transporter signature motif; other site
869269004002	Walker B; other site
869269004003	D-loop; other site
869269004004	H-loop/switch region; other site
869269004005	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
869269004006	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
869269004007	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
869269004008	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
869269004009	Walker A/P-loop; other site
869269004010	ATP binding site [chemical binding]; other site
869269004011	Q-loop/lid; other site
869269004012	ABC transporter signature motif; other site
869269004013	Walker B; other site
869269004014	D-loop; other site
869269004015	H-loop/switch region; other site
869269004016	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
869269004017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269004018	Walker A/P-loop; other site
869269004019	ATP binding site [chemical binding]; other site
869269004020	Q-loop/lid; other site
869269004021	ABC transporter signature motif; other site
869269004022	Walker B; other site
869269004023	D-loop; other site
869269004024	H-loop/switch region; other site
869269004025	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
869269004027	GMP synthase; Reviewed; Region: guaA; PRK00074
869269004028	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
869269004029	AMP/PPi binding site [chemical binding]; other site
869269004030	candidate oxyanion hole; other site
869269004031	catalytic triad [active]
869269004032	potential glutamine specificity residues [chemical binding]; other site
869269004033	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
869269004034	ATP Binding subdomain [chemical binding]; other site
869269004035	Dimerization subdomain; other site
869269004036	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
869269004037	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
869269004038	DNA-binding site [nucleotide binding]; DNA binding site
869269004039	UTRA domain; Region: UTRA; pfam07702
869269004040	EamA-like transporter family; Region: EamA; pfam00892
869269004041	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
869269004042	Beta-lactamase; Region: Beta-lactamase; pfam00144
869269004043	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
869269004044	active site
869269004045	catalytic triad [active]
869269004046	oxyanion hole [active]
869269004047	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
869269004048	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269004049	active site
869269004050	motif I; other site
869269004051	motif II; other site
869269004052	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269004054	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
869269004055	active site
869269004056	catalytic residues [active]
869269004057	metal binding site [ion binding]; metal-binding site
869269004058	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
869269004059	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
869269004060	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
869269004061	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
869269004062	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
869269004063	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
869269004064	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
869269004065	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
869269004066	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
869269004067	Walker A/P-loop; other site
869269004068	ATP binding site [chemical binding]; other site
869269004069	Q-loop/lid; other site
869269004070	ABC transporter signature motif; other site
869269004071	Walker B; other site
869269004072	D-loop; other site
869269004073	H-loop/switch region; other site
869269004074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
869269004075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269004076	ABC-ATPase subunit interface; other site
869269004077	putative PBP binding loops; other site
869269004078	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
869269004079	putative ArsC-like catalytic residues; other site
869269004080	putative TRX-like catalytic residues [active]
869269004081	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
869269004082	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
869269004083	DNA binding site [nucleotide binding]
869269004084	active site
869269004085	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
869269004086	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
869269004087	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
869269004088	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
869269004089	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
869269004090	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
869269004091	predicted active site [active]
869269004092	catalytic triad [active]
869269004093	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
869269004094	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
869269004095	active site
869269004096	multimer interface [polypeptide binding]; other site
869269004097	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
869269004098	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
869269004099	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
869269004100	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
869269004101	ApbE family; Region: ApbE; pfam02424
869269004102	Predicted flavoprotein [General function prediction only]; Region: COG0431
869269004103	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
869269004104	Predicted flavoprotein [General function prediction only]; Region: COG0431
869269004105	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
869269004106	PAS domain; Region: PAS_10; pfam13596
869269004107	hypothetical protein; Provisional; Region: PRK02539
869269004108	Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751
869269004109	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
869269004110	DALR anticodon binding domain; Region: DALR_1; pfam05746
869269004111	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
869269004112	dimer interface [polypeptide binding]; other site
869269004113	motif 1; other site
869269004114	active site
869269004115	motif 2; other site
869269004116	motif 3; other site
869269004117	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
869269004118	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
869269004119	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
869269004120	active site
869269004121	catalytic tetrad [active]
869269004122	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
869269004123	Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947
869269004124	NodB motif; other site
869269004125	active site
869269004126	catalytic site [active]
869269004127	Zn binding site [ion binding]; other site
869269004128	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269004129	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269004130	Integrase core domain; Region: rve; pfam00665
869269004131	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
869269004132	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
869269004133	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
869269004134	DEAD-like helicases superfamily; Region: DEXDc; smart00487
869269004135	ATP binding site [chemical binding]; other site
869269004136	putative Mg++ binding site [ion binding]; other site
869269004137	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869269004138	nucleotide binding region [chemical binding]; other site
869269004139	ATP-binding site [chemical binding]; other site
869269004142	elongation factor Tu; Reviewed; Region: PRK00049
869269004143	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
869269004144	G1 box; other site
869269004145	GEF interaction site [polypeptide binding]; other site
869269004146	GTP/Mg2+ binding site [chemical binding]; other site
869269004147	Switch I region; other site
869269004148	G2 box; other site
869269004149	G3 box; other site
869269004150	Switch II region; other site
869269004151	G4 box; other site
869269004152	G5 box; other site
869269004153	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
869269004154	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
869269004155	Antibiotic Binding Site [chemical binding]; other site
869269004156	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
869269004157	amphipathic channel; other site
869269004158	Asn-Pro-Ala signature motifs; other site
869269004159	MucBP domain; Region: MucBP; pfam06458
869269004161	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
869269004162	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
869269004163	active site
869269004164	substrate binding site [chemical binding]; other site
869269004165	metal binding site [ion binding]; metal-binding site
869269004166	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
869269004167	catalytic residues [active]
869269004168	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
869269004169	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
869269004170	substrate binding pocket [chemical binding]; other site
869269004171	membrane-bound complex binding site; other site
869269004172	hinge residues; other site
869269004173	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
869269004174	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269004175	Walker A/P-loop; other site
869269004176	ATP binding site [chemical binding]; other site
869269004177	Q-loop/lid; other site
869269004178	ABC transporter signature motif; other site
869269004179	Walker B; other site
869269004180	D-loop; other site
869269004181	H-loop/switch region; other site
869269004182	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269004183	dimer interface [polypeptide binding]; other site
869269004184	conserved gate region; other site
869269004185	putative PBP binding loops; other site
869269004186	ABC-ATPase subunit interface; other site
869269004187	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
869269004188	TPR motif; other site
869269004189	binding surface
869269004190	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
869269004191	binding surface
869269004192	TPR motif; other site
869269004193	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
869269004194	Domain of unknown function DUF20; Region: UPF0118; pfam01594
869269004195	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
869269004196	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
869269004197	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
869269004198	gamma subunit interface [polypeptide binding]; other site
869269004199	epsilon subunit interface [polypeptide binding]; other site
869269004200	LBP interface [polypeptide binding]; other site
869269004201	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
869269004202	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
869269004203	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
869269004204	alpha subunit interaction interface [polypeptide binding]; other site
869269004205	Walker A motif; other site
869269004206	ATP binding site [chemical binding]; other site
869269004207	Walker B motif; other site
869269004208	inhibitor binding site; inhibition site
869269004209	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
869269004210	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
869269004211	core domain interface [polypeptide binding]; other site
869269004212	delta subunit interface [polypeptide binding]; other site
869269004213	epsilon subunit interface [polypeptide binding]; other site
869269004214	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
869269004215	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
869269004216	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
869269004217	beta subunit interaction interface [polypeptide binding]; other site
869269004218	Walker A motif; other site
869269004219	ATP binding site [chemical binding]; other site
869269004220	Walker B motif; other site
869269004221	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
869269004222	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
869269004223	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
869269004224	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
869269004225	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
869269004226	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
869269004227	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
869269004228	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
869269004229	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269004230	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269004231	Integrase core domain; Region: rve; pfam00665
869269004232	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869269004233	Coenzyme A binding pocket [chemical binding]; other site
869269004234	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
869269004235	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
869269004236	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
869269004237	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
869269004238	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
869269004239	dimerization interface [polypeptide binding]; other site
869269004240	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
869269004241	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869269004242	Coenzyme A binding pocket [chemical binding]; other site
869269004243	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869269004244	Coenzyme A binding pocket [chemical binding]; other site
869269004245	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
869269004246	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
869269004247	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
869269004248	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
869269004249	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
869269004250	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
869269004251	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869269004252	ATP binding site [chemical binding]; other site
869269004253	putative Mg++ binding site [ion binding]; other site
869269004254	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869269004255	nucleotide binding region [chemical binding]; other site
869269004256	ATP-binding site [chemical binding]; other site
869269004257	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
869269004258	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
869269004259	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869269004260	homodimer interface [polypeptide binding]; other site
869269004261	catalytic residue [active]
869269004262	cystathionine gamma-synthase; Reviewed; Region: PRK07269
869269004263	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
869269004264	homodimer interface [polypeptide binding]; other site
869269004265	substrate-cofactor binding pocket; other site
869269004266	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869269004267	catalytic residue [active]
869269004269	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
869269004270	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
869269004271	peptide binding site [polypeptide binding]; other site
869269004272	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
869269004273	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
869269004274	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
869269004275	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
869269004276	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
869269004277	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
869269004278	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
869269004280	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
869269004281	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
869269004282	DHH family; Region: DHH; pfam01368
869269004283	DHHA2 domain; Region: DHHA2; pfam02833
869269004284	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
869269004285	GIY-YIG motif/motif A; other site
869269004286	putative active site [active]
869269004287	putative metal binding site [ion binding]; other site
869269004288	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
869269004289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269004290	S-adenosylmethionine binding site [chemical binding]; other site
869269004291	hypothetical protein; Provisional; Region: PRK07252
869269004292	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
869269004293	RNA binding site [nucleotide binding]; other site
869269004294	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269004295	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
869269004296	active site
869269004297	motif I; other site
869269004298	motif II; other site
869269004299	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269004300	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
869269004301	active site
869269004302	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
869269004303	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
869269004304	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
869269004305	dimer interface [polypeptide binding]; other site
869269004306	ssDNA binding site [nucleotide binding]; other site
869269004307	tetramer (dimer of dimers) interface [polypeptide binding]; other site
869269004308	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
869269004309	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
869269004310	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
869269004311	putative dimer interface [polypeptide binding]; other site
869269004312	putative anticodon binding site; other site
869269004313	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
869269004314	homodimer interface [polypeptide binding]; other site
869269004315	motif 1; other site
869269004316	motif 2; other site
869269004317	active site
869269004318	motif 3; other site
869269004319	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
869269004320	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
869269004321	aspartate aminotransferase; Provisional; Region: PRK05764
869269004322	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
869269004323	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869269004324	homodimer interface [polypeptide binding]; other site
869269004325	catalytic residue [active]
869269004326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
869269004327	Predicted flavoprotein [General function prediction only]; Region: COG0431
869269004328	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
869269004329	G5 domain; Region: G5; pfam07501
869269004330	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
869269004331	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
869269004332	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
869269004333	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
869269004334	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
869269004335	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
869269004336	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
869269004337	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
869269004338	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
869269004339	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
869269004340	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
869269004341	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
869269004342	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
869269004343	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
869269004344	Mga helix-turn-helix domain; Region: Mga; pfam05043
869269004345	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
869269004346	hypothetical protein; Validated; Region: PRK02101
869269004347	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
869269004348	active site
869269004349	catalytic residues [active]
869269004350	metal binding site [ion binding]; metal-binding site
869269004351	putative S-transferase; Provisional; Region: PRK11752
869269004352	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
869269004353	C-terminal domain interface [polypeptide binding]; other site
869269004354	GSH binding site (G-site) [chemical binding]; other site
869269004355	dimer interface [polypeptide binding]; other site
869269004356	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
869269004357	N-terminal domain interface [polypeptide binding]; other site
869269004358	dimer interface [polypeptide binding]; other site
869269004359	substrate binding pocket (H-site) [chemical binding]; other site
869269004360	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
869269004361	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
869269004362	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
869269004363	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
869269004364	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
869269004365	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
869269004366	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
869269004367	Cation efflux family; Region: Cation_efflux; pfam01545
869269004368	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
869269004369	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
869269004370	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269004371	Walker A/P-loop; other site
869269004372	ATP binding site [chemical binding]; other site
869269004373	Q-loop/lid; other site
869269004374	ABC transporter signature motif; other site
869269004375	Walker B; other site
869269004376	D-loop; other site
869269004377	H-loop/switch region; other site
869269004378	ABC transporter; Region: ABC_tran_2; pfam12848
869269004379	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
869269004380	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
869269004381	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
869269004382	active site
869269004383	NTP binding site [chemical binding]; other site
869269004384	metal binding triad [ion binding]; metal-binding site
869269004385	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
869269004386	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
869269004387	dihydrodipicolinate reductase; Provisional; Region: PRK00048
869269004388	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
869269004389	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
869269004390	EDD domain protein, DegV family; Region: DegV; TIGR00762
869269004391	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
869269004392	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835
869269004393	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
869269004394	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
869269004395	active site
869269004396	substrate binding site [chemical binding]; other site
869269004397	metal binding site [ion binding]; metal-binding site
869269004398	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
869269004399	YbbR-like protein; Region: YbbR; pfam07949
869269004400	Uncharacterized conserved protein [Function unknown]; Region: COG1624
869269004401	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
869269004402	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
869269004403	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
869269004404	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
869269004405	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
869269004406	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
869269004407	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
869269004408	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
869269004409	dimer interface [polypeptide binding]; other site
869269004410	phosphate binding site [ion binding]; other site
869269004411	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
869269004412	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
869269004413	homotrimer interaction site [polypeptide binding]; other site
869269004414	putative active site [active]
869269004415	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
869269004416	G1 box; other site
869269004417	GTP/Mg2+ binding site [chemical binding]; other site
869269004418	Switch I region; other site
869269004419	G2 box; other site
869269004420	G3 box; other site
869269004421	Switch II region; other site
869269004422	G4 box; other site
869269004423	G5 box; other site
869269004424	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
869269004425	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
869269004426	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
869269004427	Walker A motif; other site
869269004428	ATP binding site [chemical binding]; other site
869269004429	Walker B motif; other site
869269004430	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
869269004431	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
869269004432	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
869269004433	folate binding site [chemical binding]; other site
869269004434	NADP+ binding site [chemical binding]; other site
869269004435	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
869269004436	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
869269004437	dimerization interface [polypeptide binding]; other site
869269004438	DPS ferroxidase diiron center [ion binding]; other site
869269004439	ion pore; other site
869269004440	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
869269004441	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
869269004442	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
869269004443	active site
869269004444	triosephosphate isomerase; Provisional; Region: PRK14567
869269004445	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
869269004446	substrate binding site [chemical binding]; other site
869269004447	dimer interface [polypeptide binding]; other site
869269004448	catalytic triad [active]
869269004449	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
869269004450	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
869269004451	Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897
869269004452	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
869269004453	proposed active site lysine [active]
869269004454	conserved cys residue [active]
869269004455	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
869269004456	active site
869269004457	Methyltransferase domain; Region: Methyltransf_31; pfam13847
869269004458	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269004459	S-adenosylmethionine binding site [chemical binding]; other site
869269004460	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
869269004461	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
869269004462	Walker A/P-loop; other site
869269004463	ATP binding site [chemical binding]; other site
869269004464	Q-loop/lid; other site
869269004465	ABC transporter signature motif; other site
869269004466	Walker B; other site
869269004467	D-loop; other site
869269004468	H-loop/switch region; other site
869269004469	TOBE domain; Region: TOBE_2; pfam08402
869269004470	Isochorismatase family; Region: Isochorismatase; pfam00857
869269004471	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
869269004472	catalytic triad [active]
869269004473	conserved cis-peptide bond; other site
869269004474	Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465
869269004475	CodY GAF-like domain; Region: CodY; pfam06018
869269004476	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
869269004477	putative DNA binding site [nucleotide binding]; other site
869269004478	putative Zn2+ binding site [ion binding]; other site
869269004479	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
869269004480	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
869269004481	ATP binding site [chemical binding]; other site
869269004482	Mg++ binding site [ion binding]; other site
869269004483	motif III; other site
869269004484	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869269004485	nucleotide binding region [chemical binding]; other site
869269004486	ATP-binding site [chemical binding]; other site
869269004488	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
869269004489	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
869269004490	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
869269004491	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
869269004492	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
869269004493	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
869269004494	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
869269004495	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
869269004496	catalytic triad [active]
869269004497	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
869269004498	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
869269004499	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
869269004500	active site
869269004501	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
869269004502	putative transposase OrfB; Reviewed; Region: PHA02517
869269004503	HTH-like domain; Region: HTH_21; pfam13276
869269004504	Integrase core domain; Region: rve; pfam00665
869269004505	Integrase core domain; Region: rve_2; pfam13333
869269004507	Predicted membrane protein [Function unknown]; Region: COG4720
869269004508	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
869269004509	dimer interface [polypeptide binding]; other site
869269004510	substrate binding site [chemical binding]; other site
869269004511	ATP binding site [chemical binding]; other site
869269004512	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
869269004513	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
869269004514	dimerization interface 3.5A [polypeptide binding]; other site
869269004515	active site
869269004516	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
869269004517	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
869269004518	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
869269004519	PhnA protein; Region: PhnA; pfam03831
869269004520	cytidylate kinase; Provisional; Region: cmk; PRK00023
869269004521	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
869269004522	CMP-binding site; other site
869269004523	The sites determining sugar specificity; other site
869269004524	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
869269004525	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
869269004526	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
869269004527	Ligand binding site; other site
869269004528	Putative Catalytic site; other site
869269004529	DXD motif; other site
869269004530	UDP-glucose 4-epimerase; Region: PLN02240
869269004531	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
869269004532	NAD binding site [chemical binding]; other site
869269004533	homodimer interface [polypeptide binding]; other site
869269004534	active site
869269004535	substrate binding site [chemical binding]; other site
869269004536	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
869269004537	Uncharacterized conserved protein [Function unknown]; Region: COG0327
869269004538	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
869269004539	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
869269004540	Family of unknown function (DUF633); Region: DUF633; pfam04816
869269004541	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
869269004542	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
869269004543	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
869269004544	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269004545	motif II; other site
869269004546	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
869269004547	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
869269004548	putative acyl-acceptor binding pocket; other site
869269004549	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
869269004550	Cadmium resistance transporter; Region: Cad; pfam03596
869269004551	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
869269004552	16S/18S rRNA binding site [nucleotide binding]; other site
869269004553	S13e-L30e interaction site [polypeptide binding]; other site
869269004554	25S rRNA binding site [nucleotide binding]; other site
869269004557	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
869269004558	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
869269004559	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
869269004560	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
869269004561	active site
869269004562	dimer interface [polypeptide binding]; other site
869269004563	motif 1; other site
869269004564	motif 2; other site
869269004565	motif 3; other site
869269004566	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
869269004567	anticodon binding site; other site
869269004568	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
869269004569	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269004570	ATP binding site [chemical binding]; other site
869269004571	Mg2+ binding site [ion binding]; other site
869269004572	G-X-G motif; other site
869269004573	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
869269004574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
869269004575	active site
869269004576	phosphorylation site [posttranslational modification]
869269004577	intermolecular recognition site; other site
869269004578	dimerization interface [polypeptide binding]; other site
869269004579	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
869269004580	DNA binding site [nucleotide binding]
869269004581	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
869269004582	nucleophilic elbow; other site
869269004583	catalytic triad; other site
869269004584	Predicted transcriptional regulator [Transcription]; Region: COG1959
869269004585	Transcriptional regulator; Region: Rrf2; pfam02082
869269004586	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
869269004587	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
869269004588	active site
869269004589	metal binding site [ion binding]; metal-binding site
869269004590	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
869269004591	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
869269004592	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
869269004593	FeoA domain; Region: FeoA; pfam04023
869269004595	Start and end of CDS inferred from Fasta hits
869269004596	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
869269004597	putative active site [active]
869269004598	dimerization interface [polypeptide binding]; other site
869269004599	putative tRNAtyr binding site [nucleotide binding]; other site
869269004600	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
869269004601	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
869269004602	Zn2+ binding site [ion binding]; other site
869269004603	Mg2+ binding site [ion binding]; other site
869269004604	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
869269004605	synthetase active site [active]
869269004606	NTP binding site [chemical binding]; other site
869269004607	metal binding site [ion binding]; metal-binding site
869269004608	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
869269004609	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
869269004610	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
869269004611	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
869269004612	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
869269004613	active site
869269004614	Zn binding site [ion binding]; other site
869269004615	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269004616	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269004617	Integrase core domain; Region: rve; pfam00665
869269004618	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
869269004619	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
869269004620	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
869269004621	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
869269004622	ABC-ATPase subunit  interface; other site
869269004623	dimer interface [polypeptide binding]; other site
869269004624	putative PBP binding regions; other site
869269004625	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
869269004626	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
869269004627	metal binding site [ion binding]; metal-binding site
869269004628	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
869269004629	dimer interface [polypeptide binding]; other site
869269004630	catalytic triad [active]
869269004631	peroxidatic and resolving cysteines [active]
869269004633	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
869269004634	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
869269004635	Walker A/P-loop; other site
869269004636	ATP binding site [chemical binding]; other site
869269004637	Q-loop/lid; other site
869269004638	ABC transporter signature motif; other site
869269004639	Walker B; other site
869269004640	D-loop; other site
869269004641	H-loop/switch region; other site
869269004642	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
869269004643	catalytic core [active]
869269004644	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
869269004645	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
869269004646	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
869269004647	active site
869269004648	HIGH motif; other site
869269004649	nucleotide binding site [chemical binding]; other site
869269004650	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
869269004651	active site
869269004652	KMSKS motif; other site
869269004653	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
869269004654	tRNA binding surface [nucleotide binding]; other site
869269004655	anticodon binding site; other site
869269004656	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
869269004657	DivIVA domain; Region: DivI1A_domain; TIGR03544
869269004658	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
869269004659	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
869269004660	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
869269004661	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
869269004662	RNA binding surface [nucleotide binding]; other site
869269004663	YGGT family; Region: YGGT; pfam02325
869269004664	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
869269004665	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
869269004666	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
869269004667	catalytic residue [active]
869269004668	cell division protein FtsZ; Validated; Region: PRK09330
869269004669	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
869269004670	nucleotide binding site [chemical binding]; other site
869269004671	SulA interaction site; other site
869269004672	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
869269004673	Cell division protein FtsA; Region: FtsA; smart00842
869269004674	Cell division protein FtsA; Region: FtsA; pfam14450
869269004675	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
869269004676	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
869269004677	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
869269004678	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
869269004679	nudix motif; other site
869269004680	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
869269004681	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
869269004682	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
869269004683	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
869269004684	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
869269004685	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
869269004686	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
869269004687	recombination protein RecR; Reviewed; Region: recR; PRK00076
869269004688	RecR protein; Region: RecR; pfam02132
869269004689	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
869269004690	putative active site [active]
869269004691	putative metal-binding site [ion binding]; other site
869269004692	tetramer interface [polypeptide binding]; other site
869269004693	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
869269004694	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
869269004695	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
869269004696	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
869269004697	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
869269004698	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
869269004699	putative active site [active]
869269004700	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
869269004701	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
869269004702	nucleotide binding site [chemical binding]; other site
869269004703	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
869269004704	Class I aldolases; Region: Aldolase_Class_I; cl17187
869269004705	catalytic residue [active]
869269004706	Protein of unknown function, DUF624; Region: DUF624; pfam04854
869269004707	Domain of unknown function (DUF386); Region: DUF386; pfam04074
869269004708	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
869269004709	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269004710	dimer interface [polypeptide binding]; other site
869269004711	conserved gate region; other site
869269004712	putative PBP binding loops; other site
869269004713	ABC-ATPase subunit interface; other site
869269004714	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
869269004715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
869269004716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269004717	putative PBP binding loops; other site
869269004718	dimer interface [polypeptide binding]; other site
869269004719	ABC-ATPase subunit interface; other site
869269004720	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
869269004721	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
869269004722	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
869269004723	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
869269004724	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
869269004725	active site turn [active]
869269004726	phosphorylation site [posttranslational modification]
869269004727	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
869269004728	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
869269004729	putative active site cavity [active]
869269004730	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
869269004731	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
869269004732	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
869269004733	Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409
869269004734	Sialidase, N-terminal domain; Region: Sialidase; pfam02973
869269004735	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
869269004736	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
869269004737	Asp-box motif; other site
869269004738	catalytic site [active]
869269004739	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
869269004740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269004741	dimer interface [polypeptide binding]; other site
869269004742	conserved gate region; other site
869269004743	putative PBP binding loops; other site
869269004744	ABC-ATPase subunit interface; other site
869269004745	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
869269004746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269004747	dimer interface [polypeptide binding]; other site
869269004748	conserved gate region; other site
869269004749	putative PBP binding loops; other site
869269004750	ABC-ATPase subunit interface; other site
869269004751	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
869269004752	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
869269004753	uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022
869269004754	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
869269004755	Sialidase, N-terminal domain; Region: Sialidase; pfam02973
869269004756	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
869269004757	catalytic site [active]
869269004758	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
869269004759	Asp-box motif; other site
869269004760	Asp-box motif; other site
869269004761	catalytic site [active]
869269004762	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
869269004763	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
869269004764	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
869269004765	ssDNA binding site; other site
869269004766	generic binding surface II; other site
869269004767	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869269004768	ATP binding site [chemical binding]; other site
869269004769	putative Mg++ binding site [ion binding]; other site
869269004770	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869269004771	nucleotide binding region [chemical binding]; other site
869269004772	ATP-binding site [chemical binding]; other site
869269004773	alanine racemase; Reviewed; Region: alr; PRK00053
869269004774	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
869269004775	active site
869269004776	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
869269004777	dimer interface [polypeptide binding]; other site
869269004778	substrate binding site [chemical binding]; other site
869269004779	catalytic residues [active]
869269004780	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
869269004781	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
869269004782	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
869269004783	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
869269004784	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
869269004785	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
869269004786	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
869269004787	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869269004788	nucleotide binding region [chemical binding]; other site
869269004789	ATP-binding site [chemical binding]; other site
869269004790	SEC-C motif; Region: SEC-C; pfam02810
869269004791	protein-export membrane protein SecD; Region: secD; TIGR01129
869269004792	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
869269004793	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
869269004794	Walker A/P-loop; other site
869269004795	ATP binding site [chemical binding]; other site
869269004796	Q-loop/lid; other site
869269004797	ABC transporter signature motif; other site
869269004798	Walker B; other site
869269004799	D-loop; other site
869269004800	H-loop/switch region; other site
869269004801	GTP-binding protein Der; Reviewed; Region: PRK00093
869269004802	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
869269004803	G1 box; other site
869269004804	GTP/Mg2+ binding site [chemical binding]; other site
869269004805	Switch I region; other site
869269004806	G2 box; other site
869269004807	Switch II region; other site
869269004808	G3 box; other site
869269004809	G4 box; other site
869269004810	G5 box; other site
869269004811	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
869269004812	G1 box; other site
869269004813	GTP/Mg2+ binding site [chemical binding]; other site
869269004814	Switch I region; other site
869269004815	G2 box; other site
869269004816	G3 box; other site
869269004817	Switch II region; other site
869269004818	G4 box; other site
869269004819	G5 box; other site
869269004820	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
869269004821	dimer interface [polypeptide binding]; other site
869269004822	FMN binding site [chemical binding]; other site
869269004823	NADPH bind site [chemical binding]; other site
869269004824	primosomal protein DnaI; Reviewed; Region: PRK08939
869269004825	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
869269004826	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
869269004827	Walker A motif; other site
869269004828	ATP binding site [chemical binding]; other site
869269004829	Walker B motif; other site
869269004830	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
869269004831	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
869269004832	ATP cone domain; Region: ATP-cone; pfam03477
869269004833	Predicted transcriptional regulators [Transcription]; Region: COG1725
869269004834	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
869269004835	DNA-binding site [nucleotide binding]; DNA binding site
869269004836	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
869269004837	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
869269004838	Walker A/P-loop; other site
869269004839	ATP binding site [chemical binding]; other site
869269004840	Q-loop/lid; other site
869269004841	ABC transporter signature motif; other site
869269004842	Walker B; other site
869269004843	D-loop; other site
869269004844	H-loop/switch region; other site
869269004845	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
869269004846	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
869269004847	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269004848	Walker A/P-loop; other site
869269004849	ATP binding site [chemical binding]; other site
869269004850	Q-loop/lid; other site
869269004851	ABC transporter signature motif; other site
869269004852	Walker B; other site
869269004853	D-loop; other site
869269004854	H-loop/switch region; other site
869269004855	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
869269004856	Uncharacterized conserved protein [Function unknown]; Region: COG0398
869269004857	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
869269004858	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
869269004859	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
869269004860	nucleotide binding site [chemical binding]; other site
869269004861	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
869269004862	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
869269004863	active site turn [active]
869269004864	phosphorylation site [posttranslational modification]
869269004865	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
869269004866	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
869269004867	HPr interaction site; other site
869269004868	glycerol kinase (GK) interaction site [polypeptide binding]; other site
869269004869	active site
869269004870	phosphorylation site [posttranslational modification]
869269004871	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
869269004872	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
869269004873	substrate binding [chemical binding]; other site
869269004874	active site
869269004875	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
869269004876	Transcriptional regulators [Transcription]; Region: PurR; COG1609
869269004877	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
869269004878	DNA binding site [nucleotide binding]
869269004879	domain linker motif; other site
869269004880	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
869269004881	dimerization interface [polypeptide binding]; other site
869269004882	ligand binding site [chemical binding]; other site
869269004883	sodium binding site [ion binding]; other site
869269004884	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
869269004885	homodimer interface [polypeptide binding]; other site
869269004886	catalytic residues [active]
869269004887	NAD binding site [chemical binding]; other site
869269004888	substrate binding pocket [chemical binding]; other site
869269004889	flexible flap; other site
869269004890	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
869269004891	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
869269004892	dimer interface [polypeptide binding]; other site
869269004893	active site
869269004894	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
869269004895	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
869269004896	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
869269004897	Uncharacterized conserved protein [Function unknown]; Region: COG3610
869269004898	Uncharacterized conserved protein [Function unknown]; Region: COG2966
869269004899	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
869269004900	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
869269004901	Catalytic domain of Protein Kinases; Region: PKc; cd00180
869269004902	active site
869269004903	ATP binding site [chemical binding]; other site
869269004904	substrate binding site [chemical binding]; other site
869269004905	activation loop (A-loop); other site
869269004906	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
869269004907	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
869269004908	PASTA domain; Region: PASTA; smart00740
869269004909	PASTA domain; Region: PASTA; smart00740
869269004910	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
869269004911	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
869269004912	active site
869269004913	16S rRNA methyltransferase B; Provisional; Region: PRK14902
869269004914	NusB family; Region: NusB; pfam01029
869269004915	putative RNA binding site [nucleotide binding]; other site
869269004916	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269004917	S-adenosylmethionine binding site [chemical binding]; other site
869269004918	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
869269004919	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
869269004920	putative active site [active]
869269004921	substrate binding site [chemical binding]; other site
869269004922	putative cosubstrate binding site; other site
869269004923	catalytic site [active]
869269004924	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
869269004925	substrate binding site [chemical binding]; other site
869269004926	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
869269004927	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869269004928	ATP binding site [chemical binding]; other site
869269004929	putative Mg++ binding site [ion binding]; other site
869269004930	helicase superfamily c-terminal domain; Region: HELICc; smart00490
869269004931	ATP-binding site [chemical binding]; other site
869269004932	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
869269004933	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
869269004934	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
869269004935	catalytic site [active]
869269004936	G-X2-G-X-G-K; other site
869269004937	hypothetical protein; Provisional; Region: PRK00106
869269004938	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
869269004939	Zn2+ binding site [ion binding]; other site
869269004940	Mg2+ binding site [ion binding]; other site
869269004941	hypothetical protein; Provisional; Region: PRK13670
869269004942	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
869269004943	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
869269004944	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269004945	S-adenosylmethionine binding site [chemical binding]; other site
869269004946	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
869269004947	Isochorismatase family; Region: Isochorismatase; pfam00857
869269004948	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
869269004949	catalytic triad [active]
869269004950	conserved cis-peptide bond; other site
869269004951	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
869269004952	Zn2+ binding site [ion binding]; other site
869269004953	Mg2+ binding site [ion binding]; other site
869269004954	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
869269004955	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
869269004956	active site
869269004957	(T/H)XGH motif; other site
869269004958	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
869269004959	GTPase YqeH; Provisional; Region: PRK13796
869269004960	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
869269004961	GTP/Mg2+ binding site [chemical binding]; other site
869269004962	G4 box; other site
869269004963	G5 box; other site
869269004964	G1 box; other site
869269004965	Switch I region; other site
869269004966	G2 box; other site
869269004967	G3 box; other site
869269004968	Switch II region; other site
869269004969	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
869269004970	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269004971	active site
869269004972	motif I; other site
869269004973	motif II; other site
869269004974	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
869269004975	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
869269004976	Cl binding site [ion binding]; other site
869269004977	oligomer interface [polypeptide binding]; other site
869269004978	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
869269004979	Mechanosensitive ion channel; Region: MS_channel; pfam00924
869269004980	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
869269004981	serine/threonine transporter SstT; Provisional; Region: PRK14695
869269004982	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
869269004983	Predicted membrane protein [Function unknown]; Region: COG4129
869269004984	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
869269004985	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
869269004986	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
869269004987	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
869269004988	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
869269004989	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
869269004990	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
869269004991	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
869269004992	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
869269004993	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
869269004994	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
869269004995	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
869269004996	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
869269004997	Adenylate cyclase associated (CAP) N terminal; Region: CAP_N; pfam01213
869269004998	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
869269004999	SecY translocase; Region: SecY; pfam00344
869269005001	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
869269005002	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
869269005003	Ligand binding site; other site
869269005004	metal-binding site
869269005005	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
869269005006	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
869269005007	Ligand binding site; other site
869269005008	metal-binding site
869269005009	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
869269005010	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
869269005011	Ligand binding site; other site
869269005012	metal-binding site
869269005013	glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728
869269005014	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
869269005015	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
869269005016	active site
869269005017	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
869269005018	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
869269005019	trimer interface [polypeptide binding]; other site
869269005020	active site
869269005021	substrate binding site [chemical binding]; other site
869269005022	CoA binding site [chemical binding]; other site
869269005024	serine-rich repeat adhesion glycoprotein AST domain; Region: ser_adhes_Nterm; TIGR04224
869269005025	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
869269005026	DDE superfamily endonuclease; Region: DDE_3; pfam13358
869269005027	MarR family; Region: MarR; pfam01047
869269005028	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
869269005029	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
869269005030	catalytic residues [active]
869269005031	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
869269005032	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
869269005033	amphipathic channel; other site
869269005034	Asn-Pro-Ala signature motifs; other site
869269005035	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
869269005036	oligoendopeptidase F; Region: pepF; TIGR00181
869269005037	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
869269005038	Zn binding site [ion binding]; other site
869269005039	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
869269005040	RNA methyltransferase, RsmE family; Region: TIGR00046
869269005041	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
869269005042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269005043	S-adenosylmethionine binding site [chemical binding]; other site
869269005044	Peptidase family M50; Region: Peptidase_M50; pfam02163
869269005045	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
869269005046	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
869269005047	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269005048	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269005049	Integrase core domain; Region: rve; pfam00665
869269005050	recombination factor protein RarA; Reviewed; Region: PRK13342
869269005051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
869269005052	Walker A motif; other site
869269005053	ATP binding site [chemical binding]; other site
869269005054	Walker B motif; other site
869269005055	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
869269005056	arginine finger; other site
869269005057	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
869269005058	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
869269005059	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
869269005060	substrate binding [chemical binding]; other site
869269005061	active site
869269005062	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
869269005063	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
869269005064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269005065	dimer interface [polypeptide binding]; other site
869269005066	conserved gate region; other site
869269005067	putative PBP binding loops; other site
869269005068	ABC-ATPase subunit interface; other site
869269005069	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269005070	dimer interface [polypeptide binding]; other site
869269005071	conserved gate region; other site
869269005072	putative PBP binding loops; other site
869269005073	ABC-ATPase subunit interface; other site
869269005074	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
869269005075	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
869269005076	Transcriptional regulators [Transcription]; Region: PurR; COG1609
869269005077	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
869269005078	DNA binding site [nucleotide binding]
869269005079	domain linker motif; other site
869269005080	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
869269005081	dimerization interface [polypeptide binding]; other site
869269005082	ligand binding site [chemical binding]; other site
869269005083	sodium binding site [ion binding]; other site
869269005084	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
869269005085	Mga helix-turn-helix domain; Region: Mga; pfam05043
869269005086	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
869269005087	Predicted membrane protein [Function unknown]; Region: COG2261
869269005088	Small integral membrane protein [Function unknown]; Region: COG5547
869269005089	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
869269005091	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
869269005092	Uncharacterized conserved protein [Function unknown]; Region: COG1262
869269005093	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
869269005094	arylsulfatase; Provisional; Region: PRK13759
869269005095	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
869269005096	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
869269005097	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
869269005098	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
869269005099	active site
869269005100	methionine cluster; other site
869269005101	phosphorylation site [posttranslational modification]
869269005102	metal binding site [ion binding]; metal-binding site
869269005103	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
869269005104	active site
869269005105	P-loop; other site
869269005106	phosphorylation site [posttranslational modification]
869269005107	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
869269005108	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
869269005109	active site
869269005110	catalytic residues [active]
869269005111	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270
869269005112	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
869269005113	MarR family; Region: MarR_2; pfam12802
869269005114	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
869269005115	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
869269005116	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
869269005117	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869269005118	Coenzyme A binding pocket [chemical binding]; other site
869269005119	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
869269005120	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
869269005121	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
869269005122	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
869269005123	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869269005124	non-specific DNA binding site [nucleotide binding]; other site
869269005125	salt bridge; other site
869269005126	sequence-specific DNA binding site [nucleotide binding]; other site
869269005127	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
869269005128	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
869269005129	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
869269005130	substrate binding site [chemical binding]; other site
869269005131	active site
869269005132	catalytic residues [active]
869269005133	heterodimer interface [polypeptide binding]; other site
869269005134	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
869269005135	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
869269005136	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869269005137	catalytic residue [active]
869269005138	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
869269005139	active site
869269005140	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
869269005141	active site
869269005142	ribulose/triose binding site [chemical binding]; other site
869269005143	phosphate binding site [ion binding]; other site
869269005144	substrate (anthranilate) binding pocket [chemical binding]; other site
869269005145	product (indole) binding pocket [chemical binding]; other site
869269005146	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
869269005147	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
869269005148	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
869269005149	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
869269005150	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
869269005151	glutamine binding [chemical binding]; other site
869269005152	catalytic triad [active]
869269005153	anthranilate synthase component I; Provisional; Region: PRK13570
869269005154	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
869269005155	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
869269005156	Transcriptional regulators [Transcription]; Region: PurR; COG1609
869269005157	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
869269005158	DNA binding site [nucleotide binding]
869269005159	domain linker motif; other site
869269005160	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
869269005161	putative dimerization interface [polypeptide binding]; other site
869269005162	putative ligand binding site [chemical binding]; other site
869269005163	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
869269005164	MgtC family; Region: MgtC; pfam02308
869269005165	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
869269005166	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269005167	dimer interface [polypeptide binding]; other site
869269005168	conserved gate region; other site
869269005169	putative PBP binding loops; other site
869269005170	ABC-ATPase subunit interface; other site
869269005171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269005172	putative PBP binding loops; other site
869269005173	dimer interface [polypeptide binding]; other site
869269005174	ABC-ATPase subunit interface; other site
869269005175	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
869269005176	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269005177	Walker A/P-loop; other site
869269005178	ATP binding site [chemical binding]; other site
869269005179	Q-loop/lid; other site
869269005180	ABC transporter signature motif; other site
869269005181	Walker B; other site
869269005182	D-loop; other site
869269005183	H-loop/switch region; other site
869269005184	TOBE domain; Region: TOBE; pfam03459
869269005185	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
869269005186	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
869269005187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255
869269005188	Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975
869269005189	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269005190	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269005191	Integrase core domain; Region: rve; pfam00665
869269005192	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
869269005193	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
869269005194	Pectate lyase; Region: Pec_lyase_C; cl01593
869269005195	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
869269005196	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
869269005197	inhibitor-cofactor binding pocket; inhibition site
869269005198	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869269005199	catalytic residue [active]
869269005200	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
869269005201	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
869269005202	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
869269005203	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
869269005204	Walker A/P-loop; other site
869269005205	ATP binding site [chemical binding]; other site
869269005206	Q-loop/lid; other site
869269005207	ABC transporter signature motif; other site
869269005208	Walker B; other site
869269005209	D-loop; other site
869269005210	H-loop/switch region; other site
869269005211	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
869269005212	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
869269005213	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269005214	Walker A/P-loop; other site
869269005215	ATP binding site [chemical binding]; other site
869269005216	Q-loop/lid; other site
869269005217	ABC transporter signature motif; other site
869269005218	Walker B; other site
869269005219	D-loop; other site
869269005220	H-loop/switch region; other site
869269005223	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
869269005224	active site
869269005225	putative catalytic site [active]
869269005226	DNA binding site [nucleotide binding]
869269005227	putative phosphate binding site [ion binding]; other site
869269005228	metal binding site A [ion binding]; metal-binding site
869269005229	AP binding site [nucleotide binding]; other site
869269005230	metal binding site B [ion binding]; metal-binding site
869269005231	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
869269005232	active site
869269005233	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
869269005234	active site
869269005235	xanthine permease; Region: pbuX; TIGR03173
869269005236	Sulfate transporter family; Region: Sulfate_transp; pfam00916
869269005237	DpnII restriction endonuclease; Region: DpnII; pfam04556
869269005238	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
869269005239	DNA methylase; Region: N6_N4_Mtase; pfam01555
869269005240	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269005241	S-adenosylmethionine binding site [chemical binding]; other site
869269005242	DNA adenine methylase (dam); Region: dam; TIGR00571
869269005243	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
869269005244	CoenzymeA binding site [chemical binding]; other site
869269005245	subunit interaction site [polypeptide binding]; other site
869269005246	PHB binding site; other site
869269005247	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
869269005248	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
869269005249	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
869269005250	galactokinase; Provisional; Region: PRK05322
869269005251	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
869269005252	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
869269005253	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
869269005254	Transcriptional regulators [Transcription]; Region: PurR; COG1609
869269005255	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
869269005256	DNA binding site [nucleotide binding]
869269005257	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
869269005258	putative dimerization interface [polypeptide binding]; other site
869269005259	putative ligand binding site [chemical binding]; other site
869269005260	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
869269005261	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
869269005262	catalytic Zn binding site [ion binding]; other site
869269005263	NAD(P) binding site [chemical binding]; other site
869269005264	structural Zn binding site [ion binding]; other site
869269005265	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
869269005266	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
869269005267	DNA binding residues [nucleotide binding]
869269005268	putative dimer interface [polypeptide binding]; other site
869269005269	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
869269005270	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
869269005271	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
869269005272	nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528
869269005273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269005274	dimer interface [polypeptide binding]; other site
869269005275	conserved gate region; other site
869269005276	ABC-ATPase subunit interface; other site
869269005277	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
869269005278	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
869269005279	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
869269005280	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269005281	Walker A/P-loop; other site
869269005282	ATP binding site [chemical binding]; other site
869269005283	Q-loop/lid; other site
869269005284	ABC transporter signature motif; other site
869269005285	Walker B; other site
869269005286	D-loop; other site
869269005287	H-loop/switch region; other site
869269005288	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4922
869269005289	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
869269005290	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
869269005291	Enterocin A Immunity; Region: EntA_Immun; pfam08951
869269005292	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
869269005293	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
869269005294	oligomer interface [polypeptide binding]; other site
869269005295	active site
869269005296	metal binding site [ion binding]; metal-binding site
869269005297	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
869269005298	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
869269005299	NAD(P) binding site [chemical binding]; other site
869269005300	active site
869269005301	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
869269005302	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
869269005303	ABC-ATPase subunit  interface; other site
869269005304	dimer interface [polypeptide binding]; other site
869269005305	putative PBP binding regions; other site
869269005306	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
869269005307	ABC-ATPase subunit  interface; other site
869269005308	dimer interface [polypeptide binding]; other site
869269005309	putative PBP binding regions; other site
869269005310	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
869269005311	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
869269005312	Walker A/P-loop; other site
869269005313	ATP binding site [chemical binding]; other site
869269005314	Q-loop/lid; other site
869269005315	ABC transporter signature motif; other site
869269005316	Walker B; other site
869269005317	D-loop; other site
869269005318	H-loop/switch region; other site
869269005319	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
869269005320	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
869269005321	putative ligand binding residues [chemical binding]; other site
869269005322	hypothetical protein; Validated; Region: PRK00041
869269005323	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
869269005324	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
869269005325	RNA binding surface [nucleotide binding]; other site
869269005326	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
869269005327	active site
869269005328	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
869269005329	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
869269005330	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
869269005331	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
869269005332	DNA binding site [nucleotide binding]
869269005333	Int/Topo IB signature motif; other site
869269005334	active site
869269005335	catalytic residues [active]
869269005336	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
869269005337	FOG: CBS domain [General function prediction only]; Region: COG0517
869269005338	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
869269005339	active site
869269005340	metal binding site [ion binding]; metal-binding site
869269005341	homotetramer interface [polypeptide binding]; other site
869269005342	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
869269005343	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
869269005344	active site
869269005345	dimerization interface [polypeptide binding]; other site
869269005346	glutamate racemase; Provisional; Region: PRK00865
869269005347	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
869269005348	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
869269005349	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
869269005350	Ca binding site [ion binding]; other site
869269005351	active site
869269005352	catalytic site [active]
869269005353	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
869269005354	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
869269005355	active site turn [active]
869269005356	phosphorylation site [posttranslational modification]
869269005357	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
869269005358	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
869269005359	HPr interaction site; other site
869269005360	glycerol kinase (GK) interaction site [polypeptide binding]; other site
869269005361	active site
869269005362	phosphorylation site [posttranslational modification]
869269005363	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
869269005364	DNA-binding site [nucleotide binding]; DNA binding site
869269005365	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
869269005366	UTRA domain; Region: UTRA; pfam07702
869269005367	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
869269005368	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269005369	Walker A/P-loop; other site
869269005370	ATP binding site [chemical binding]; other site
869269005371	Q-loop/lid; other site
869269005372	ABC transporter signature motif; other site
869269005373	Walker B; other site
869269005374	D-loop; other site
869269005375	H-loop/switch region; other site
869269005378	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269005379	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269005380	Integrase core domain; Region: rve; pfam00665
869269005381	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
869269005382	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
869269005383	Walker A/P-loop; other site
869269005384	ATP binding site [chemical binding]; other site
869269005385	Q-loop/lid; other site
869269005386	ABC transporter signature motif; other site
869269005387	Walker B; other site
869269005388	D-loop; other site
869269005389	H-loop/switch region; other site
869269005390	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
869269005391	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
869269005392	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
869269005393	Walker A/P-loop; other site
869269005394	ATP binding site [chemical binding]; other site
869269005395	Q-loop/lid; other site
869269005396	ABC transporter signature motif; other site
869269005397	Walker B; other site
869269005398	D-loop; other site
869269005399	H-loop/switch region; other site
869269005400	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
869269005401	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
869269005402	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
869269005403	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269005404	dimer interface [polypeptide binding]; other site
869269005405	conserved gate region; other site
869269005406	putative PBP binding loops; other site
869269005407	ABC-ATPase subunit interface; other site
869269005408	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
869269005409	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269005410	dimer interface [polypeptide binding]; other site
869269005411	conserved gate region; other site
869269005412	putative PBP binding loops; other site
869269005413	ABC-ATPase subunit interface; other site
869269005414	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
869269005415	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
869269005416	peptide binding site [polypeptide binding]; other site
869269005417	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
869269005418	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
869269005419	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
869269005420	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
869269005421	active site
869269005422	homodimer interface [polypeptide binding]; other site
869269005423	catalytic site [active]
869269005425	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269005426	dimer interface [polypeptide binding]; other site
869269005427	conserved gate region; other site
869269005428	putative PBP binding loops; other site
869269005429	ABC-ATPase subunit interface; other site
869269005430	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
869269005431	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
869269005432	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
869269005433	Melibiase; Region: Melibiase; pfam02065
869269005434	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
869269005435	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869269005436	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
869269005437	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
869269005438	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
869269005439	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
869269005440	DNA-binding site [nucleotide binding]; DNA binding site
869269005441	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
869269005442	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
869269005443	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
869269005444	TRAM domain; Region: TRAM; cl01282
869269005445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269005446	S-adenosylmethionine binding site [chemical binding]; other site
869269005447	recombination regulator RecX; Provisional; Region: recX; PRK14135
869269005448	hypothetical protein; Provisional; Region: PRK13662
869269005449	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
869269005450	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
869269005451	ring oligomerisation interface [polypeptide binding]; other site
869269005452	ATP/Mg binding site [chemical binding]; other site
869269005453	stacking interactions; other site
869269005454	hinge regions; other site
869269005455	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
869269005456	oligomerisation interface [polypeptide binding]; other site
869269005457	mobile loop; other site
869269005458	roof hairpin; other site
869269005459	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
869269005460	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
869269005461	dimer interface [polypeptide binding]; other site
869269005462	ssDNA binding site [nucleotide binding]; other site
869269005463	tetramer (dimer of dimers) interface [polypeptide binding]; other site
869269005464	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
869269005465	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
869269005466	putative NAD(P) binding site [chemical binding]; other site
869269005467	homodimer interface [polypeptide binding]; other site
869269005468	homotetramer interface [polypeptide binding]; other site
869269005469	active site
869269005470	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
869269005471	putative tRNA-binding site [nucleotide binding]; other site
869269005472	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
869269005473	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
869269005474	catalytic residues [active]
869269005475	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
869269005476	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
869269005477	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
869269005478	LytTr DNA-binding domain; Region: LytTR; pfam04397
869269005479	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
869269005480	active site
869269005481	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
869269005482	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4898
869269005483	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
869269005484	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269005485	Walker A/P-loop; other site
869269005486	ATP binding site [chemical binding]; other site
869269005487	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
869269005488	Walker A/P-loop; other site
869269005489	ATP binding site [chemical binding]; other site
869269005490	Q-loop/lid; other site
869269005491	ABC transporter signature motif; other site
869269005492	Walker B; other site
869269005493	D-loop; other site
869269005494	H-loop/switch region; other site
869269005495	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
869269005496	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
869269005498	hypothetical protein; Provisional; Region: PRK12378
869269005499	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
869269005500	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
869269005501	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
869269005502	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
869269005503	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869269005504	non-specific DNA binding site [nucleotide binding]; other site
869269005505	salt bridge; other site
869269005506	sequence-specific DNA binding site [nucleotide binding]; other site
869269005507	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
869269005508	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
869269005509	amidase catalytic site [active]
869269005510	Zn binding residues [ion binding]; other site
869269005511	substrate binding site [chemical binding]; other site
869269005512	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269005513	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269005514	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
869269005515	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
869269005516	recombinase A; Provisional; Region: recA; PRK09354
869269005517	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
869269005518	hexamer interface [polypeptide binding]; other site
869269005519	Walker A motif; other site
869269005520	ATP binding site [chemical binding]; other site
869269005521	Walker B motif; other site
869269005522	competence damage-inducible protein A; Provisional; Region: PRK00549
869269005523	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
869269005524	putative MPT binding site; other site
869269005525	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
869269005526	Transcriptional regulator [Transcription]; Region: LytR; COG1316
869269005527	putative acetyltransferase YhhY; Provisional; Region: PRK10140
869269005528	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
869269005529	Coenzyme A binding pocket [chemical binding]; other site
869269005530	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
869269005532	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
869269005533	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
869269005534	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
869269005535	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
869269005536	Walker A/P-loop; other site
869269005537	ATP binding site [chemical binding]; other site
869269005538	Q-loop/lid; other site
869269005539	ABC transporter signature motif; other site
869269005540	Walker B; other site
869269005541	D-loop; other site
869269005542	H-loop/switch region; other site
869269005543	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
869269005544	active site
869269005545	multimer interface [polypeptide binding]; other site
869269005546	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
869269005547	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
869269005548	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
869269005549	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
869269005550	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
869269005551	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
869269005552	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
869269005553	G-loop; other site
869269005554	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
869269005555	DNA binding site [nucleotide binding]
869269005556	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
869269005557	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
869269005558	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
869269005559	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
869269005560	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
869269005561	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
869269005562	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
869269005563	RPB1 interaction site [polypeptide binding]; other site
869269005564	RPB10 interaction site [polypeptide binding]; other site
869269005565	RPB11 interaction site [polypeptide binding]; other site
869269005566	RPB3 interaction site [polypeptide binding]; other site
869269005567	RPB12 interaction site [polypeptide binding]; other site
869269005568	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
869269005569	Domain of unknown function DUF21; Region: DUF21; pfam01595
869269005570	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
869269005571	Transporter associated domain; Region: CorC_HlyC; smart01091
869269005572	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
869269005573	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
869269005574	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
869269005575	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
869269005576	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
869269005577	hinge; other site
869269005578	active site
869269005579	Protein of unknown function (DUF1146); Region: DUF1146; pfam06612
869269005580	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
869269005581	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
869269005582	protein binding site [polypeptide binding]; other site
869269005583	Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669
869269005584	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
869269005585	active site
869269005586	(T/H)XGH motif; other site
869269005587	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
869269005588	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269005589	S-adenosylmethionine binding site [chemical binding]; other site
869269005590	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
869269005591	dimer interface [polypeptide binding]; other site
869269005592	active site
869269005593	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
869269005594	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
869269005595	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
869269005596	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
869269005597	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
869269005598	acylphosphatase; Provisional; Region: PRK14434
869269005599	OxaA-like protein precursor; Provisional; Region: PRK02463
869269005600	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
869269005601	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
869269005602	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
869269005603	FeS/SAM binding site; other site
869269005604	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
869269005605	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
869269005606	active site
869269005607	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
869269005608	substrate binding site [chemical binding]; other site
869269005609	catalytic residues [active]
869269005610	dimer interface [polypeptide binding]; other site
869269005611	pur operon repressor; Provisional; Region: PRK09213
869269005612	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
869269005613	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
869269005614	active site
869269005615	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
869269005616	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
869269005617	generic binding surface II; other site
869269005618	generic binding surface I; other site
869269005619	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
869269005620	Zn2+ binding site [ion binding]; other site
869269005621	Mg2+ binding site [ion binding]; other site
869269005622	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
869269005623	RmuC family; Region: RmuC; pfam02646
869269005624	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
869269005625	Thiamine pyrophosphokinase; Region: TPK; cd07995
869269005626	active site
869269005627	dimerization interface [polypeptide binding]; other site
869269005628	thiamine binding site [chemical binding]; other site
869269005630	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
869269005631	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269005632	S-adenosylmethionine binding site [chemical binding]; other site
869269005633	Appears to have been disrupted by a BOX element insertion
869269005634	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
869269005635	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
869269005636	Walker A/P-loop; other site
869269005637	ATP binding site [chemical binding]; other site
869269005638	Q-loop/lid; other site
869269005639	ABC transporter signature motif; other site
869269005640	Walker B; other site
869269005641	D-loop; other site
869269005642	H-loop/switch region; other site
869269005643	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
869269005644	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
869269005645	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
869269005646	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869269005647	non-specific DNA binding site [nucleotide binding]; other site
869269005648	salt bridge; other site
869269005649	sequence-specific DNA binding site [nucleotide binding]; other site
869269005650	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
869269005651	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
869269005652	putative active site [active]
869269005653	putative metal binding site [ion binding]; other site
869269005654	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
869269005655	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
869269005656	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
869269005657	active site
869269005658	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
869269005659	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
869269005660	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269005661	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269005662	Integrase core domain; Region: rve; pfam00665
869269005663	aminotransferase AlaT; Validated; Region: PRK09265
869269005664	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
869269005665	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869269005666	homodimer interface [polypeptide binding]; other site
869269005667	catalytic residue [active]
869269005668	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
869269005669	Ligand Binding Site [chemical binding]; other site
869269005670	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269005671	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
869269005672	active site
869269005673	motif I; other site
869269005674	motif II; other site
869269005675	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269005676	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
869269005677	putative nucleotide binding site [chemical binding]; other site
869269005678	putative metal binding site [ion binding]; other site
869269005679	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
869269005680	active site
869269005681	homotetramer interface [polypeptide binding]; other site
869269005682	homodimer interface [polypeptide binding]; other site
869269005683	catabolite control protein A; Region: ccpA; TIGR01481
869269005684	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
869269005685	DNA binding site [nucleotide binding]
869269005686	domain linker motif; other site
869269005687	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
869269005688	dimerization interface [polypeptide binding]; other site
869269005689	effector binding site; other site
869269005690	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
869269005691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
869269005692	active site
869269005693	phosphorylation site [posttranslational modification]
869269005694	intermolecular recognition site; other site
869269005695	dimerization interface [polypeptide binding]; other site
869269005696	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
869269005697	DNA binding residues [nucleotide binding]
869269005698	dimerization interface [polypeptide binding]; other site
869269005699	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
869269005700	Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333
869269005701	Histidine kinase; Region: HisKA_3; pfam07730
869269005702	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269005703	ATP binding site [chemical binding]; other site
869269005704	Mg2+ binding site [ion binding]; other site
869269005705	G-X-G motif; other site
869269005706	ABC-2 type transporter; Region: ABC2_membrane; cl17235
869269005707	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
869269005708	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
869269005709	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
869269005710	Walker A/P-loop; other site
869269005711	ATP binding site [chemical binding]; other site
869269005712	Q-loop/lid; other site
869269005713	ABC transporter signature motif; other site
869269005714	Walker B; other site
869269005715	D-loop; other site
869269005716	H-loop/switch region; other site
869269005717	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
869269005718	Helix-turn-helix domain; Region: HTH_38; pfam13936
869269005719	Integrase core domain; Region: rve; pfam00665
869269005720	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
869269005721	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
869269005722	putative homodimer interface [polypeptide binding]; other site
869269005723	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
869269005724	heterodimer interface [polypeptide binding]; other site
869269005725	homodimer interface [polypeptide binding]; other site
869269005726	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
869269005727	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
869269005728	Transglycosylase; Region: Transgly; pfam00912
869269005729	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
869269005730	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
869269005731	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
869269005732	active site
869269005733	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
869269005734	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
869269005735	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
869269005736	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
869269005737	FtsX-like permease family; Region: FtsX; pfam02687
869269005739	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559
869269005740	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
869269005741	dimerization interface [polypeptide binding]; other site
869269005742	active site
869269005743	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
869269005744	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
869269005745	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
869269005746	Walker A/P-loop; other site
869269005747	ATP binding site [chemical binding]; other site
869269005748	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
869269005749	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
869269005750	DNA-binding site [nucleotide binding]; DNA binding site
869269005751	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
869269005752	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
869269005753	beta-galactosidase; Region: BGL; TIGR03356
869269005754	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
869269005755	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
869269005756	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
869269005757	active site
869269005758	P-loop; other site
869269005759	phosphorylation site [posttranslational modification]
869269005760	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
869269005761	methionine cluster; other site
869269005762	active site
869269005763	phosphorylation site [posttranslational modification]
869269005764	metal binding site [ion binding]; metal-binding site
869269005765	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
869269005766	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
869269005767	putative catalytic cysteine [active]
869269005768	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
869269005769	putative active site [active]
869269005770	metal binding site [ion binding]; metal-binding site
869269005771	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
869269005772	MORN repeat; Region: MORN; cl14787
869269005773	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
869269005774	Low molecular weight phosphatase family; Region: LMWPc; cd00115
869269005775	active site
869269005776	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
869269005777	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
869269005778	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
869269005779	TPP-binding site [chemical binding]; other site
869269005780	dimer interface [polypeptide binding]; other site
869269005781	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
869269005782	PYR/PP interface [polypeptide binding]; other site
869269005783	dimer interface [polypeptide binding]; other site
869269005784	TPP binding site [chemical binding]; other site
869269005785	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
869269005786	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
869269005787	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
869269005788	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
869269005789	PRD domain; Region: PRD; pfam00874
869269005790	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
869269005791	active site
869269005792	P-loop; other site
869269005793	phosphorylation site [posttranslational modification]
869269005794	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
869269005795	L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145
869269005796	intersubunit interface [polypeptide binding]; other site
869269005797	active site
869269005798	Zn2+ binding site [ion binding]; other site
869269005799	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
869269005800	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
869269005801	AP (apurinic/apyrimidinic) site pocket; other site
869269005802	DNA interaction; other site
869269005803	Metal-binding active site; metal-binding site
869269005804	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
869269005805	active site
869269005806	dimer interface [polypeptide binding]; other site
869269005807	magnesium binding site [ion binding]; other site
869269005808	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
869269005809	active site
869269005810	phosphorylation site [posttranslational modification]
869269005811	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
869269005812	active site
869269005813	P-loop; other site
869269005814	phosphorylation site [posttranslational modification]
869269005815	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
869269005816	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
869269005817	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
869269005818	G-X-X-G motif; other site
869269005819	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
869269005820	RxxxH motif; other site
869269005821	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
869269005822	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
869269005823	ribonuclease P; Reviewed; Region: rnpA; PRK00499
869269005824	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
869269005825	propionate/acetate kinase; Provisional; Region: PRK12379
869269005826	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
869269005827	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269005828	S-adenosylmethionine binding site [chemical binding]; other site
869269005829	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
869269005830	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
869269005831	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
869269005832	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
869269005833	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
869269005834	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
869269005835	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
869269005836	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
869269005837	Walker A motif; other site
869269005838	ATP binding site [chemical binding]; other site
869269005839	Walker B motif; other site
869269005840	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
869269005841	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
869269005842	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
869269005843	catalytic Zn binding site [ion binding]; other site
869269005844	structural Zn binding site [ion binding]; other site
869269005845	NAD(P) binding site [chemical binding]; other site
869269005846	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
869269005847	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
869269005848	active site
869269005849	dimer interface [polypeptide binding]; other site
869269005850	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
869269005851	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
869269005852	catalytic triad [active]
869269005853	catalytic triad [active]
869269005854	oxyanion hole [active]
869269005855	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
869269005856	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
869269005857	Predicted integral membrane protein [Function unknown]; Region: COG5523
869269005858	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
869269005859	putative substrate binding pocket [chemical binding]; other site
869269005860	AC domain interface; other site
869269005861	catalytic triad [active]
869269005862	AB domain interface; other site
869269005863	interchain disulfide; other site
869269005864	Predicted membrane protein [Function unknown]; Region: COG3759
869269005865	Transcriptional regulators [Transcription]; Region: MarR; COG1846
869269005866	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
869269005867	putative DNA binding site [nucleotide binding]; other site
869269005868	putative Zn2+ binding site [ion binding]; other site
869269005869	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
869269005870	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
869269005871	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269005872	motif II; other site
869269005873	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
869269005874	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
869269005875	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
869269005876	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
869269005877	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869269005878	catalytic residue [active]
869269005879	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
869269005880	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
869269005881	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
869269005882	active site
869269005883	HIGH motif; other site
869269005884	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
869269005885	active site
869269005886	KMSKS motif; other site
869269005887	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
869269005888	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
869269005889	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
869269005890	active site
869269005891	dimer interface [polypeptide binding]; other site
869269005892	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
869269005893	dimer interface [polypeptide binding]; other site
869269005894	active site
869269005895	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
869269005896	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
869269005897	catalytic triad [active]
869269005898	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
869269005899	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
869269005900	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269005901	Walker A/P-loop; other site
869269005902	ATP binding site [chemical binding]; other site
869269005903	Q-loop/lid; other site
869269005904	ABC transporter signature motif; other site
869269005905	Walker B; other site
869269005906	D-loop; other site
869269005907	H-loop/switch region; other site
869269005908	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
869269005909	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
869269005910	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
869269005911	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
869269005912	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269005913	Walker A/P-loop; other site
869269005914	ATP binding site [chemical binding]; other site
869269005915	Q-loop/lid; other site
869269005916	ABC transporter signature motif; other site
869269005917	Walker B; other site
869269005918	D-loop; other site
869269005919	H-loop/switch region; other site
869269005920	DNA mismatch repair protein MutS; Region: mutS1; TIGR01070
869269005921	MutS domain I; Region: MutS_I; pfam01624
869269005922	MutS domain II; Region: MutS_II; pfam05188
869269005923	MutS domain III; Region: MutS_III; pfam05192
869269005924	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
869269005925	Walker A/P-loop; other site
869269005926	ATP binding site [chemical binding]; other site
869269005927	Q-loop/lid; other site
869269005928	ABC transporter signature motif; other site
869269005929	Walker B; other site
869269005930	D-loop; other site
869269005931	H-loop/switch region; other site
869269005932	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
869269005933	arginine repressor; Region: argR_whole; TIGR01529
869269005934	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
869269005935	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
869269005936	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
869269005937	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
869269005938	active site
869269005939	HIGH motif; other site
869269005940	KMSK motif region; other site
869269005941	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
869269005942	tRNA binding surface [nucleotide binding]; other site
869269005943	anticodon binding site; other site
869269005944	Uncharacterized conserved protein [Function unknown]; Region: COG3542
869269005945	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
869269005946	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
869269005947	active site
869269005948	phosphorylation site [posttranslational modification]
869269005949	intermolecular recognition site; other site
869269005950	dimerization interface [polypeptide binding]; other site
869269005951	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
869269005952	DNA binding site [nucleotide binding]
869269005953	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
869269005954	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
869269005955	dimer interface [polypeptide binding]; other site
869269005956	phosphorylation site [posttranslational modification]
869269005957	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269005958	ATP binding site [chemical binding]; other site
869269005959	G-X-G motif; other site
869269005960	PBP superfamily domain; Region: PBP_like_2; cl17296
869269005961	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
869269005962	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
869269005963	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269005964	dimer interface [polypeptide binding]; other site
869269005965	conserved gate region; other site
869269005966	putative PBP binding loops; other site
869269005967	ABC-ATPase subunit interface; other site
869269005968	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
869269005969	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269005970	dimer interface [polypeptide binding]; other site
869269005971	conserved gate region; other site
869269005972	putative PBP binding loops; other site
869269005973	ABC-ATPase subunit interface; other site
869269005974	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
869269005975	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
869269005976	Walker A/P-loop; other site
869269005977	ATP binding site [chemical binding]; other site
869269005978	Q-loop/lid; other site
869269005979	ABC transporter signature motif; other site
869269005980	Walker B; other site
869269005981	D-loop; other site
869269005982	H-loop/switch region; other site
869269005983	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
869269005984	PhoU domain; Region: PhoU; pfam01895
869269005985	PhoU domain; Region: PhoU; pfam01895
869269005986	DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502
869269005988	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
869269005989	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
869269005990	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
869269005991	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
869269005992	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
869269005993	active site
869269005994	tetramer interface; other site
869269005995	Rhomboid family; Region: Rhomboid; pfam01694
869269005996	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
869269005997	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
869269005998	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
869269005999	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
869269006000	metal binding site [ion binding]; metal-binding site
869269006001	putative dimer interface [polypeptide binding]; other site
869269006002	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
869269006003	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
869269006004	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
869269006005	trimer interface [polypeptide binding]; other site
869269006006	active site
869269006007	substrate binding site [chemical binding]; other site
869269006008	CoA binding site [chemical binding]; other site
869269006009	EamA-like transporter family; Region: EamA; pfam00892
869269006010	Transglycosylase; Region: Transgly; pfam00912
869269006011	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
869269006012	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
869269006013	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
869269006014	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
869269006015	active site
869269006016	HIGH motif; other site
869269006017	dimer interface [polypeptide binding]; other site
869269006018	KMSKS motif; other site
869269006019	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
869269006020	RNA binding surface [nucleotide binding]; other site
869269006021	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
869269006022	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
869269006023	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
869269006024	motif II; other site
869269006025	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
869269006026	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
869269006027	S-adenosylmethionine binding site [chemical binding]; other site
869269006028	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
869269006029	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
869269006030	4-alpha-glucanotransferase; Provisional; Region: PRK14508
869269006031	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
869269006032	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
869269006033	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269006034	dimer interface [polypeptide binding]; other site
869269006035	conserved gate region; other site
869269006036	putative PBP binding loops; other site
869269006037	ABC-ATPase subunit interface; other site
869269006038	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
869269006039	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
869269006040	dimer interface [polypeptide binding]; other site
869269006041	conserved gate region; other site
869269006042	putative PBP binding loops; other site
869269006043	ABC-ATPase subunit interface; other site
869269006044	Predicted integral membrane protein [Function unknown]; Region: COG5521
869269006045	Transcriptional regulators [Transcription]; Region: PurR; COG1609
869269006046	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
869269006047	DNA binding site [nucleotide binding]
869269006048	domain linker motif; other site
869269006049	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
869269006050	putative dimerization interface [polypeptide binding]; other site
869269006051	putative ligand binding site [chemical binding]; other site
869269006052	Uncharacterized conserved protein [Function unknown]; Region: COG1284
869269006053	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
869269006054	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
869269006055	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
869269006056	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
869269006057	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
869269006058	dimer interface [polypeptide binding]; other site
869269006059	anticodon binding site; other site
869269006060	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
869269006061	homodimer interface [polypeptide binding]; other site
869269006062	motif 1; other site
869269006063	active site
869269006064	motif 2; other site
869269006065	GAD domain; Region: GAD; pfam02938
869269006066	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
869269006067	motif 3; other site
869269006068	CAAX protease self-immunity; Region: Abi; pfam02517
869269006069	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
869269006070	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869269006071	non-specific DNA binding site [nucleotide binding]; other site
869269006072	salt bridge; other site
869269006073	sequence-specific DNA binding site [nucleotide binding]; other site
869269006074	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
869269006075	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
869269006076	dimer interface [polypeptide binding]; other site
869269006077	motif 1; other site
869269006078	active site
869269006079	motif 2; other site
869269006080	motif 3; other site
869269006081	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
869269006082	anticodon binding site; other site
869269006084	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
869269006085	non-specific DNA binding site [nucleotide binding]; other site
869269006086	salt bridge; other site
869269006087	sequence-specific DNA binding site [nucleotide binding]; other site
869269006088	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
869269006089	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
869269006090	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
869269006091	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
869269006092	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
869269006093	PYR/PP interface [polypeptide binding]; other site
869269006094	dimer interface [polypeptide binding]; other site
869269006095	TPP binding site [chemical binding]; other site
869269006096	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
869269006097	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
869269006098	TPP-binding site [chemical binding]; other site
869269006099	dimer interface [polypeptide binding]; other site
869269006100	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
869269006101	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
869269006102	active site
869269006103	P-loop; other site
869269006104	phosphorylation site [posttranslational modification]
869269006105	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
869269006106	PRD domain; Region: PRD; pfam00874
869269006107	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
869269006108	active site
869269006109	P-loop; other site
869269006110	phosphorylation site [posttranslational modification]
869269006111	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
869269006112	active site
869269006113	phosphorylation site [posttranslational modification]
869269006114	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
869269006115	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
869269006116	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
869269006117	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
869269006118	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
869269006119	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
869269006120	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
869269006121	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269006122	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269006123	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269006124	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269006125	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269006126	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269006127	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269006130	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
869269006131	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
869269006132	putative active site [active]
869269006133	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
869269006134	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
869269006135	nucleotide binding site [chemical binding]; other site
869269006136	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
869269006137	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
869269006138	active site
869269006139	metal binding site [ion binding]; metal-binding site
869269006140	homodimer interface [polypeptide binding]; other site
869269006141	catalytic site [active]
869269006142	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
869269006143	Uncharacterized conserved protein [Function unknown]; Region: COG3538
869269006144	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
869269006145	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
869269006146	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
869269006147	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
869269006148	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
869269006149	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
869269006150	arginine deiminase; Provisional; Region: PRK01388
869269006151	ornithine carbamoyltransferase; Validated; Region: PRK02102
869269006152	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
869269006153	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
869269006154	carbamate kinase; Reviewed; Region: PRK12686
869269006155	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
869269006156	putative substrate binding site [chemical binding]; other site
869269006157	nucleotide binding site [chemical binding]; other site
869269006158	nucleotide binding site [chemical binding]; other site
869269006159	homodimer interface [polypeptide binding]; other site
869269006160	Predicted membrane protein [Function unknown]; Region: COG1288
869269006161	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
869269006162	hypothetical protein; Provisional; Region: PRK07205
869269006163	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
869269006164	active site
869269006165	metal binding site [ion binding]; metal-binding site
869269006167	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
869269006168	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
869269006169	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
869269006170	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
869269006171	dimer interface [polypeptide binding]; other site
869269006172	active site
869269006173	metal binding site [ion binding]; metal-binding site
869269006174	L-fucose isomerase; Provisional; Region: fucI; PRK10991
869269006175	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
869269006176	hexamer (dimer of trimers) interface [polypeptide binding]; other site
869269006177	trimer interface [polypeptide binding]; other site
869269006178	substrate binding site [chemical binding]; other site
869269006179	Mn binding site [ion binding]; other site
869269006180	Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306
869269006181	Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307
869269006182	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
869269006183	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
869269006184	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
869269006185	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
869269006186	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
869269006187	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
869269006188	active site
869269006189	phosphorylation site [posttranslational modification]
869269006190	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
869269006191	active pocket/dimerization site; other site
869269006192	active site
869269006193	phosphorylation site [posttranslational modification]
869269006194	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
869269006195	L-fuculose phosphate aldolase; Provisional; Region: PRK06833
869269006196	intersubunit interface [polypeptide binding]; other site
869269006197	active site
869269006198	Zn2+ binding site [ion binding]; other site
869269006199	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
869269006200	N- and C-terminal domain interface [polypeptide binding]; other site
869269006201	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
869269006202	active site
869269006203	putative catalytic site [active]
869269006204	metal binding site [ion binding]; metal-binding site
869269006205	ATP binding site [chemical binding]; other site
869269006206	carbohydrate binding site [chemical binding]; other site
869269006207	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
869269006208	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
869269006209	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
869269006210	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
869269006211	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
869269006212	metal binding site [ion binding]; metal-binding site
869269006213	YodA lipocalin-like domain; Region: YodA; pfam09223
869269006214	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
869269006215	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
869269006216	ABC-ATPase subunit  interface; other site
869269006217	dimer interface [polypeptide binding]; other site
869269006218	putative PBP binding regions; other site
869269006219	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
869269006220	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
869269006221	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
869269006222	putative DNA binding site [nucleotide binding]; other site
869269006223	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
869269006224	DltD N-terminal region; Region: DltD_N; pfam04915
869269006225	DltD central region; Region: DltD_M; pfam04918
869269006226	DltD C-terminal region; Region: DltD_C; pfam04914
869269006227	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
869269006228	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
869269006229	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
869269006230	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
869269006231	acyl-activating enzyme (AAE) consensus motif; other site
869269006232	AMP binding site [chemical binding]; other site
869269006233	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
869269006234	putative substrate translocation pore; other site
869269006236	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
869269006237	amphipathic channel; other site
869269006238	Asn-Pro-Ala signature motifs; other site
869269006239	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
869269006240	glycerol kinase; Provisional; Region: glpK; PRK00047
869269006241	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
869269006242	N- and C-terminal domain interface [polypeptide binding]; other site
869269006243	active site
869269006244	MgATP binding site [chemical binding]; other site
869269006245	catalytic site [active]
869269006246	metal binding site [ion binding]; metal-binding site
869269006247	glycerol binding site [chemical binding]; other site
869269006248	homotetramer interface [polypeptide binding]; other site
869269006249	homodimer interface [polypeptide binding]; other site
869269006250	FBP binding site [chemical binding]; other site
869269006251	protein IIAGlc interface [polypeptide binding]; other site
869269006252	Mga helix-turn-helix domain; Region: Mga; pfam05043
869269006253	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
869269006254	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
869269006255	dimerization interface [polypeptide binding]; other site
869269006256	domain crossover interface; other site
869269006257	redox-dependent activation switch; other site
869269006258	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
869269006259	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
869269006260	FMN binding site [chemical binding]; other site
869269006261	active site
869269006262	catalytic residues [active]
869269006263	substrate binding site [chemical binding]; other site
869269006264	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
869269006265	RICH domain; Region: RICH; pfam05062
869269006266	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269006267	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269006268	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269006269	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269006270	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
869269006271	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269006272	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
869269006273	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
869269006274	HAMP domain; Region: HAMP; pfam00672
869269006275	dimerization interface [polypeptide binding]; other site
869269006276	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
869269006277	dimer interface [polypeptide binding]; other site
869269006278	phosphorylation site [posttranslational modification]
869269006279	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
869269006280	ATP binding site [chemical binding]; other site
869269006281	Mg2+ binding site [ion binding]; other site
869269006282	G-X-G motif; other site
869269006283	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
869269006284	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
869269006285	active site
869269006286	phosphorylation site [posttranslational modification]
869269006287	intermolecular recognition site; other site
869269006288	dimerization interface [polypeptide binding]; other site
869269006289	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
869269006290	DNA binding site [nucleotide binding]
869269006291	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
869269006292	Clp amino terminal domain; Region: Clp_N; pfam02861
869269006293	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
869269006294	Walker A motif; other site
869269006295	ATP binding site [chemical binding]; other site
869269006296	Walker B motif; other site
869269006297	arginine finger; other site
869269006298	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
869269006299	Walker A motif; other site
869269006300	ATP binding site [chemical binding]; other site
869269006301	Walker B motif; other site
869269006302	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
869269006303	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
869269006304	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
869269006305	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
869269006306	Walker A/P-loop; other site
869269006307	ATP binding site [chemical binding]; other site
869269006308	Q-loop/lid; other site
869269006309	ABC transporter signature motif; other site
869269006310	Walker B; other site
869269006311	D-loop; other site
869269006312	H-loop/switch region; other site
869269006313	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
869269006314	NMT1/THI5 like; Region: NMT1; pfam09084
869269006315	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
869269006316	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
869269006317	putative PBP binding loops; other site
869269006318	ABC-ATPase subunit interface; other site
869269006319	Uncharacterized conserved protein [Function unknown]; Region: COG0011
869269006320	Surface antigen [General function prediction only]; Region: COG3942
869269006321	CHAP domain; Region: CHAP; pfam05257
869269006322	Bacterial SH3 domain; Region: SH3_5; pfam08460
869269006323	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
869269006324	Bacterial SH3 domain; Region: SH3_5; pfam08460
869269006325	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
869269006326	Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466
869269006327	replicative DNA helicase; Provisional; Region: PRK05748
869269006328	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
869269006329	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
869269006330	Walker A motif; other site
869269006331	ATP binding site [chemical binding]; other site
869269006332	Walker B motif; other site
869269006333	DNA binding loops [nucleotide binding]
869269006334	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
869269006335	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
869269006336	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
869269006337	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
869269006338	DHH family; Region: DHH; pfam01368
869269006339	DHHA1 domain; Region: DHHA1; pfam02272
869269006340	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
869269006341	30S subunit binding site; other site
869269006342	comF family protein; Region: comF; TIGR00201
869269006343	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
869269006344	active site
869269006345	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
869269006346	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
869269006347	ATP binding site [chemical binding]; other site
869269006348	putative Mg++ binding site [ion binding]; other site
869269006349	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
869269006350	nucleotide binding region [chemical binding]; other site
869269006351	ATP-binding site [chemical binding]; other site
869269006352	Uncharacterized conserved protein [Function unknown]; Region: COG1739
869269006353	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
869269006354	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
869269006355	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
869269006356	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
869269006357	dimer interface [polypeptide binding]; other site
869269006358	pyridoxal 5'-phosphate binding site [chemical binding]; other site
869269006359	catalytic residue [active]
869269006363	elongation factor Ts; Provisional; Region: tsf; PRK09377
869269006364	UBA/TS-N domain; Region: UBA; pfam00627
869269006365	Elongation factor TS; Region: EF_TS; pfam00889
869269006366	Elongation factor TS; Region: EF_TS; pfam00889
869269006367	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
869269006368	rRNA interaction site [nucleotide binding]; other site
869269006369	S8 interaction site; other site
869269006370	putative laminin-1 binding site; other site
869269006371	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
869269006372	Septum formation initiator; Region: DivIC; cl17659
869269006373	Surface antigen [General function prediction only]; Region: COG3942
869269006374	CHAP domain; Region: CHAP; pfam05257
869269006375	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
869269006376	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
869269006377	rod shape-determining protein MreC; Region: MreC; pfam04085
869269006378	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
869269006379	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
869269006380	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
869269006381	Walker A/P-loop; other site
869269006382	ATP binding site [chemical binding]; other site
869269006383	Q-loop/lid; other site
869269006384	ABC transporter signature motif; other site
869269006385	Walker B; other site
869269006386	D-loop; other site
869269006387	H-loop/switch region; other site
869269006388	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
869269006389	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
869269006390	Walker A/P-loop; other site
869269006391	ATP binding site [chemical binding]; other site
869269006392	Q-loop/lid; other site
869269006393	ABC transporter signature motif; other site
869269006394	Walker B; other site
869269006395	D-loop; other site
869269006396	H-loop/switch region; other site
869269006397	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
869269006398	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
869269006399	Helix-turn-helix domain; Region: HTH_25; pfam13413
869269006400	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
869269006401	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
869269006402	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
869269006403	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
869269006404	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
869269006405	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
869269006406	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
869269006407	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
869269006408	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
869269006409	Walker A/P-loop; other site
869269006410	ATP binding site [chemical binding]; other site
869269006411	Q-loop/lid; other site
869269006412	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
869269006413	ABC transporter signature motif; other site
869269006414	Walker B; other site
869269006415	D-loop; other site
869269006416	H-loop/switch region; other site
869269006417	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
869269006418	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
869269006419	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
869269006420	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
869269006421	active site
869269006422	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
869269006423	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
869269006424	active site
869269006425	HIGH motif; other site
869269006426	dimer interface [polypeptide binding]; other site
869269006427	KMSKS motif; other site
869269006428	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
869269006429	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
869269006430	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
869269006431	ABC transporter; Region: ABC_tran_2; pfam12848
869269006432	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
869269006433	Predicted membrane protein [Function unknown]; Region: COG4485
869269006434	Integrase core domain; Region: rve; pfam00665
869269006435	Integrase core domain; Region: rve_2; pfam13333
869269006436	Predicted membrane protein [Function unknown]; Region: COG1511
869269006437	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
869269006438	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
869269006439	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
869269006440	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
869269006441	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
869269006442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
869269006443	active site
869269006444	phosphorylation site [posttranslational modification]
869269006445	intermolecular recognition site; other site
869269006446	dimerization interface [polypeptide binding]; other site
869269006447	LytTr DNA-binding domain; Region: LytTR; pfam04397
869269006449	COMC family; Region: ComC; pfam03047
869269006450	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
869269006451	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
869269006452	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
869269006453	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
869269006454	protein binding site [polypeptide binding]; other site
869269006455	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
869269006456	ParB-like nuclease domain; Region: ParBc; pfam02195
869269006457	KorB domain; Region: KorB; pfam08535