-- dump date 20140620_084734 -- class Genbank::misc_feature -- table misc_feature_note -- id note 869216000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 869216000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216000003 Walker A motif; other site 869216000004 ATP binding site [chemical binding]; other site 869216000005 Walker B motif; other site 869216000006 arginine finger; other site 869216000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 869216000008 DnaA box-binding interface [nucleotide binding]; other site 869216000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 869216000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 869216000011 putative DNA binding surface [nucleotide binding]; other site 869216000012 dimer interface [polypeptide binding]; other site 869216000013 beta-clamp/clamp loader binding surface; other site 869216000014 beta-clamp/translesion DNA polymerase binding surface; other site 869216000015 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 869216000016 GTP-binding protein YchF; Reviewed; Region: PRK09601 869216000017 YchF GTPase; Region: YchF; cd01900 869216000018 G1 box; other site 869216000019 GTP/Mg2+ binding site [chemical binding]; other site 869216000020 Switch I region; other site 869216000021 G2 box; other site 869216000022 Switch II region; other site 869216000023 G3 box; other site 869216000024 G4 box; other site 869216000025 G5 box; other site 869216000026 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 869216000027 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 869216000028 putative active site [active] 869216000029 catalytic residue [active] 869216000030 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 869216000031 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 869216000032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869216000033 ATP binding site [chemical binding]; other site 869216000034 putative Mg++ binding site [ion binding]; other site 869216000035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869216000036 nucleotide binding region [chemical binding]; other site 869216000037 ATP-binding site [chemical binding]; other site 869216000038 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 869216000039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869216000040 RNA binding surface [nucleotide binding]; other site 869216000041 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 869216000042 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 869216000043 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 869216000044 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 869216000045 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 869216000046 Ligand Binding Site [chemical binding]; other site 869216000047 TilS substrate C-terminal domain; Region: TilS_C; smart00977 869216000048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869216000049 active site 869216000050 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 869216000051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216000052 Walker A motif; other site 869216000053 ATP binding site [chemical binding]; other site 869216000054 Walker B motif; other site 869216000055 arginine finger; other site 869216000056 Peptidase family M41; Region: Peptidase_M41; pfam01434 869216000057 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 869216000058 Transposase; Region: HTH_Tnp_IS630; pfam01710 869216000059 Helix-turn-helix domain; Region: HTH_28; pfam13518 869216000060 DDE superfamily endonuclease; Region: DDE_3; pfam13358 869216000061 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 869216000063 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 869216000064 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 869216000065 GDP-binding site [chemical binding]; other site 869216000066 ACT binding site; other site 869216000067 IMP binding site; other site 869216000068 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 869216000069 nucleoside/Zn binding site; other site 869216000070 dimer interface [polypeptide binding]; other site 869216000071 catalytic motif [active] 869216000072 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 869216000073 trimer interface [polypeptide binding]; other site 869216000074 active site 869216000075 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869216000076 catalytic core [active] 869216000077 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869216000078 DNA repair protein RadA; Provisional; Region: PRK11823 869216000079 Walker A motif; other site 869216000080 ATP binding site [chemical binding]; other site 869216000081 Walker B motif; other site 869216000082 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 869216000083 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 869216000084 active site clefts [active] 869216000085 zinc binding site [ion binding]; other site 869216000086 dimer interface [polypeptide binding]; other site 869216000087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 869216000088 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 869216000089 putative transposase OrfB; Reviewed; Region: PHA02517 869216000090 HTH-like domain; Region: HTH_21; pfam13276 869216000091 Integrase core domain; Region: rve; pfam00665 869216000092 Integrase core domain; Region: rve_2; pfam13333 869216000093 Protease prsW family; Region: PrsW-protease; cl15823 869216000094 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 869216000095 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 869216000096 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869216000097 active site 869216000098 coordinates determined manually using correlation scores plot 869216000099 coordinates determined manually using correlation scores plot 869216000100 DNA polymerase I; Provisional; Region: PRK05755 869216000101 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 869216000102 active site 869216000103 metal binding site 1 [ion binding]; metal-binding site 869216000104 putative 5' ssDNA interaction site; other site 869216000105 metal binding site 3; metal-binding site 869216000106 metal binding site 2 [ion binding]; metal-binding site 869216000107 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 869216000108 putative DNA binding site [nucleotide binding]; other site 869216000109 putative metal binding site [ion binding]; other site 869216000110 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 869216000111 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 869216000112 active site 869216000113 DNA binding site [nucleotide binding] 869216000114 catalytic site [active] 869216000115 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 869216000117 Predicted membrane protein [Function unknown]; Region: COG2855 869216000118 aromatic amino acid aminotransferase; Validated; Region: PRK07309 869216000119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869216000120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869216000121 homodimer interface [polypeptide binding]; other site 869216000122 catalytic residue [active] 869216000123 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 869216000124 Recombination protein O N terminal; Region: RecO_N; pfam11967 869216000125 Recombination protein O C terminal; Region: RecO_C; pfam02565 869216000126 putative phosphate acyltransferase; Provisional; Region: PRK05331 869216000128 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 869216000129 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 869216000130 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 869216000131 putative active site [active] 869216000132 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869216000133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216000134 Walker A/P-loop; other site 869216000135 ATP binding site [chemical binding]; other site 869216000136 Q-loop/lid; other site 869216000137 ABC transporter signature motif; other site 869216000138 Walker B; other site 869216000139 D-loop; other site 869216000140 H-loop/switch region; other site 869216000141 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 869216000142 HlyD family secretion protein; Region: HlyD_3; pfam13437 869216000143 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 869216000144 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 869216000145 ATP binding site [chemical binding]; other site 869216000146 active site 869216000147 substrate binding site [chemical binding]; other site 869216000148 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 869216000149 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 869216000150 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 869216000151 dimerization interface [polypeptide binding]; other site 869216000152 ATP binding site [chemical binding]; other site 869216000153 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 869216000154 dimerization interface [polypeptide binding]; other site 869216000155 ATP binding site [chemical binding]; other site 869216000156 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 869216000157 putative active site [active] 869216000158 catalytic triad [active] 869216000159 amidophosphoribosyltransferase; Provisional; Region: PRK07272 869216000160 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 869216000161 active site 869216000162 tetramer interface [polypeptide binding]; other site 869216000163 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869216000164 active site 869216000165 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 869216000166 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 869216000167 dimerization interface [polypeptide binding]; other site 869216000168 putative ATP binding site [chemical binding]; other site 869216000169 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 869216000170 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 869216000171 active site 869216000172 substrate binding site [chemical binding]; other site 869216000173 cosubstrate binding site; other site 869216000174 catalytic site [active] 869216000175 VanZ like family; Region: VanZ; pfam04892 869216000176 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 869216000177 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 869216000178 purine monophosphate binding site [chemical binding]; other site 869216000179 dimer interface [polypeptide binding]; other site 869216000180 putative catalytic residues [active] 869216000181 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 869216000182 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 869216000183 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 869216000184 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 869216000185 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 869216000186 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 869216000187 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 869216000188 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 869216000189 ATP-grasp domain; Region: ATP-grasp; pfam02222 869216000190 adenylosuccinate lyase; Provisional; Region: PRK07492 869216000191 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 869216000192 tetramer interface [polypeptide binding]; other site 869216000193 active site 869216000194 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869216000195 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 869216000196 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 869216000197 active site 869216000198 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 869216000199 active site 869216000200 G5 domain; Region: G5; pfam07501 869216000201 G5 domain; Region: G5; pfam07501 869216000202 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 869216000203 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869216000204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869216000205 DNA-binding site [nucleotide binding]; DNA binding site 869216000206 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 869216000207 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 869216000208 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 869216000209 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869216000210 active site 869216000211 phosphorylation site [posttranslational modification] 869216000212 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 869216000213 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869216000214 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869216000215 active pocket/dimerization site; other site 869216000216 active site 869216000217 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 869216000218 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 869216000219 dimer interface [polypeptide binding]; other site 869216000220 active site 869216000221 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 869216000222 putative active site [active] 869216000223 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 869216000224 active site 869216000225 catalytic residues [active] 869216000226 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 869216000227 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 869216000228 putative metal binding site [ion binding]; other site 869216000229 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869216000230 active site 869216000231 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 869216000232 putative homodimer interface [polypeptide binding]; other site 869216000233 putative homotetramer interface [polypeptide binding]; other site 869216000234 putative allosteric switch controlling residues; other site 869216000235 putative metal binding site [ion binding]; other site 869216000236 putative homodimer-homodimer interface [polypeptide binding]; other site 869216000237 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869216000238 active site residue [active] 869216000239 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 869216000240 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 869216000241 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 869216000242 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 869216000243 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 869216000244 TrkA-N domain; Region: TrkA_N; pfam02254 869216000246 Fibronectin-binding repeat; Region: SSURE; pfam11966 869216000247 Fibronectin-binding repeat; Region: SSURE; pfam11966 869216000248 Fibronectin-binding repeat; Region: SSURE; pfam11966 869216000249 Fibronectin-binding repeat; Region: SSURE; pfam11966 869216000250 Fibronectin-binding repeat; Region: SSURE; pfam11966 869216000251 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869216000252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869216000253 active site 869216000254 phosphorylation site [posttranslational modification] 869216000255 intermolecular recognition site; other site 869216000256 dimerization interface [polypeptide binding]; other site 869216000257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869216000258 DNA binding site [nucleotide binding] 869216000259 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869216000260 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869216000261 dimerization interface [polypeptide binding]; other site 869216000262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869216000263 dimer interface [polypeptide binding]; other site 869216000264 phosphorylation site [posttranslational modification] 869216000265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869216000266 ATP binding site [chemical binding]; other site 869216000267 Mg2+ binding site [ion binding]; other site 869216000268 G-X-G motif; other site 869216000269 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 869216000270 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 869216000271 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869216000272 RNA binding surface [nucleotide binding]; other site 869216000273 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869216000274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216000275 dimer interface [polypeptide binding]; other site 869216000276 conserved gate region; other site 869216000277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869216000278 ABC-ATPase subunit interface; other site 869216000279 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869216000280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216000281 dimer interface [polypeptide binding]; other site 869216000282 conserved gate region; other site 869216000283 putative PBP binding loops; other site 869216000284 ABC-ATPase subunit interface; other site 869216000285 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869216000286 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 869216000287 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 869216000288 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 869216000289 active site residue [active] 869216000290 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 869216000291 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 869216000292 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 869216000293 Predicted membrane protein [Function unknown]; Region: COG4709 869216000294 Predicted transcriptional regulators [Transcription]; Region: COG1695 869216000295 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 869216000296 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 869216000297 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869216000298 putative substrate translocation pore; other site 869216000299 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 869216000300 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 869216000301 Ligand binding site; other site 869216000302 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 869216000303 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869216000304 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 869216000305 NAD(P) binding site [chemical binding]; other site 869216000306 homodimer interface [polypeptide binding]; other site 869216000307 substrate binding site [chemical binding]; other site 869216000308 active site 869216000309 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 869216000310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216000311 active site 869216000312 motif I; other site 869216000313 motif II; other site 869216000314 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 869216000315 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 869216000316 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 869216000317 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 869216000318 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 869216000319 putative L-serine binding site [chemical binding]; other site 869216000320 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 869216000321 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869216000322 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 869216000323 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 869216000324 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869216000325 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869216000326 Walker A/P-loop; other site 869216000327 ATP binding site [chemical binding]; other site 869216000328 Q-loop/lid; other site 869216000329 ABC transporter signature motif; other site 869216000330 Walker B; other site 869216000331 D-loop; other site 869216000332 H-loop/switch region; other site 869216000333 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869216000334 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869216000335 substrate binding pocket [chemical binding]; other site 869216000336 membrane-bound complex binding site; other site 869216000337 hinge residues; other site 869216000338 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 869216000339 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869216000340 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216000341 non-specific DNA binding site [nucleotide binding]; other site 869216000342 salt bridge; other site 869216000343 sequence-specific DNA binding site [nucleotide binding]; other site 869216000345 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 869216000346 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216000347 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216000348 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 869216000349 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216000350 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216000351 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216000352 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216000353 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 869216000354 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216000355 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216000356 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 869216000357 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 869216000358 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 869216000359 nudix motif; other site 869216000360 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 869216000361 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 869216000362 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 869216000363 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 869216000364 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 869216000365 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 869216000366 hypothetical protein; Provisional; Region: PRK13667 869216000367 class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949 869216000368 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 869216000369 Glycoprotease family; Region: Peptidase_M22; pfam00814 869216000370 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 869216000371 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869216000372 Coenzyme A binding pocket [chemical binding]; other site 869216000373 UGMP family protein; Validated; Region: PRK09604 869216000374 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 869216000375 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 869216000376 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869216000377 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869216000381 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 869216000382 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869216000383 active site 869216000384 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869216000385 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 869216000386 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869216000387 Walker A/P-loop; other site 869216000388 ATP binding site [chemical binding]; other site 869216000389 Q-loop/lid; other site 869216000390 ABC transporter signature motif; other site 869216000391 Walker B; other site 869216000392 D-loop; other site 869216000393 H-loop/switch region; other site 869216000394 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 869216000395 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 869216000396 Ligand Binding Site [chemical binding]; other site 869216000397 Molecular Tunnel; other site 869216000398 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 869216000400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216000401 non-specific DNA binding site [nucleotide binding]; other site 869216000402 salt bridge; other site 869216000403 sequence-specific DNA binding site [nucleotide binding]; other site 869216000404 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869216000405 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 869216000406 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 869216000407 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 869216000408 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 869216000409 active site 869216000410 zinc binding site [ion binding]; other site 869216000411 H+ Antiporter protein; Region: 2A0121; TIGR00900 869216000412 CAAX protease self-immunity; Region: Abi; pfam02517 869216000413 CAAX protease self-immunity; Region: Abi; pfam02517 869216000414 AzlC protein; Region: AzlC; cl00570 869216000415 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 869216000416 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869216000417 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869216000418 substrate binding pocket [chemical binding]; other site 869216000419 membrane-bound complex binding site; other site 869216000420 hinge residues; other site 869216000422 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869216000423 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869216000424 substrate binding pocket [chemical binding]; other site 869216000425 membrane-bound complex binding site; other site 869216000426 hinge residues; other site 869216000427 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 869216000428 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 869216000429 hypothetical protein; Provisional; Region: PRK06446 869216000430 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 869216000431 metal binding site [ion binding]; metal-binding site 869216000432 dimer interface [polypeptide binding]; other site 869216000433 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 869216000434 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 869216000435 Walker A/P-loop; other site 869216000436 ATP binding site [chemical binding]; other site 869216000437 Q-loop/lid; other site 869216000438 ABC transporter signature motif; other site 869216000439 Walker B; other site 869216000440 D-loop; other site 869216000441 H-loop/switch region; other site 869216000442 NIL domain; Region: NIL; pfam09383 869216000443 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 869216000444 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 869216000445 Predicted integral membrane protein [Function unknown]; Region: COG5578 869216000446 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869216000447 HAMP domain; Region: HAMP; pfam00672 869216000448 Histidine kinase; Region: His_kinase; pfam06580 869216000449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869216000450 ATP binding site [chemical binding]; other site 869216000451 Mg2+ binding site [ion binding]; other site 869216000452 G-X-G motif; other site 869216000453 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 869216000454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869216000455 active site 869216000456 phosphorylation site [posttranslational modification] 869216000457 intermolecular recognition site; other site 869216000458 dimerization interface [polypeptide binding]; other site 869216000459 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869216000460 flavoprotein NrdI; Provisional; Region: PRK02551 869216000461 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 869216000462 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 869216000463 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869216000464 LytTr DNA-binding domain; Region: LytTR; smart00850 869216000465 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 869216000466 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869216000467 ATP binding site [chemical binding]; other site 869216000468 Mg2+ binding site [ion binding]; other site 869216000469 G-X-G motif; other site 869216000470 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 869216000471 ATP binding site [chemical binding]; other site 869216000472 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 869216000473 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 869216000474 homopentamer interface [polypeptide binding]; other site 869216000475 active site 869216000476 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 869216000477 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 869216000478 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 869216000479 dimerization interface [polypeptide binding]; other site 869216000480 active site 869216000481 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 869216000482 Lumazine binding domain; Region: Lum_binding; pfam00677 869216000483 Lumazine binding domain; Region: Lum_binding; pfam00677 869216000484 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 869216000485 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 869216000486 catalytic motif [active] 869216000487 Zn binding site [ion binding]; other site 869216000488 RibD C-terminal domain; Region: RibD_C; cl17279 869216000489 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 869216000490 RuvA N terminal domain; Region: RuvA_N; pfam01330 869216000491 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 869216000492 CAAX protease self-immunity; Region: Abi; pfam02517 869216000493 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 869216000494 putative dimer interface [polypeptide binding]; other site 869216000495 catalytic triad [active] 869216000496 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 869216000497 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 869216000498 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 869216000499 Cl binding site [ion binding]; other site 869216000500 oligomer interface [polypeptide binding]; other site 869216000501 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 869216000502 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869216000503 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869216000504 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 869216000505 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 869216000506 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 869216000507 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 869216000508 active site 869216000509 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 869216000510 ArsC family; Region: ArsC; pfam03960 869216000511 putative catalytic residues [active] 869216000512 thiol/disulfide switch; other site 869216000513 hypothetical protein; Provisional; Region: PRK05473 869216000514 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 869216000515 hypothetical protein; Provisional; Region: PRK13678 869216000516 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 869216000517 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869216000518 Bacterial lipoprotein; Region: DUF3642; pfam12182 869216000519 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 869216000520 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 869216000521 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 869216000522 putative active site [active] 869216000523 catalytic site [active] 869216000524 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 869216000525 putative active site [active] 869216000526 catalytic site [active] 869216000527 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 869216000528 ATP cone domain; Region: ATP-cone; pfam03477 869216000529 Class III ribonucleotide reductase; Region: RNR_III; cd01675 869216000530 effector binding site; other site 869216000531 active site 869216000532 Zn binding site [ion binding]; other site 869216000533 glycine loop; other site 869216000534 Predicted acetyltransferase [General function prediction only]; Region: COG3981 869216000535 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869216000536 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 869216000537 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869216000538 FeS/SAM binding site; other site 869216000539 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 869216000540 active site 869216000541 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 869216000542 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 869216000543 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 869216000544 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 869216000545 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 869216000546 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 869216000547 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 869216000548 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 869216000549 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 869216000550 putative translocon binding site; other site 869216000551 protein-rRNA interface [nucleotide binding]; other site 869216000552 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 869216000553 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 869216000554 G-X-X-G motif; other site 869216000555 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 869216000556 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 869216000557 23S rRNA interface [nucleotide binding]; other site 869216000558 5S rRNA interface [nucleotide binding]; other site 869216000559 putative antibiotic binding site [chemical binding]; other site 869216000560 L25 interface [polypeptide binding]; other site 869216000561 L27 interface [polypeptide binding]; other site 869216000562 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 869216000563 23S rRNA interface [nucleotide binding]; other site 869216000564 putative translocon interaction site; other site 869216000565 signal recognition particle (SRP54) interaction site; other site 869216000566 L23 interface [polypeptide binding]; other site 869216000567 trigger factor interaction site; other site 869216000568 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 869216000569 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 869216000570 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 869216000571 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 869216000572 RNA binding site [nucleotide binding]; other site 869216000573 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 869216000574 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 869216000575 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 869216000576 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 869216000577 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 869216000578 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 869216000579 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869216000580 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869216000581 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 869216000582 5S rRNA interface [nucleotide binding]; other site 869216000583 L27 interface [polypeptide binding]; other site 869216000584 23S rRNA interface [nucleotide binding]; other site 869216000585 L5 interface [polypeptide binding]; other site 869216000586 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 869216000587 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 869216000588 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 869216000589 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 869216000590 23S rRNA binding site [nucleotide binding]; other site 869216000591 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 869216000592 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 869216000593 SecY translocase; Region: SecY; pfam00344 869216000594 adenylate kinase; Reviewed; Region: adk; PRK00279 869216000595 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 869216000596 AMP-binding site [chemical binding]; other site 869216000597 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 869216000598 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 869216000599 rRNA binding site [nucleotide binding]; other site 869216000600 predicted 30S ribosome binding site; other site 869216000601 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 869216000602 30S ribosomal protein S13; Region: bact_S13; TIGR03631 869216000603 30S ribosomal protein S11; Validated; Region: PRK05309 869216000604 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 869216000605 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 869216000606 alphaNTD homodimer interface [polypeptide binding]; other site 869216000607 alphaNTD - beta interaction site [polypeptide binding]; other site 869216000608 alphaNTD - beta' interaction site [polypeptide binding]; other site 869216000609 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 869216000610 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 869216000611 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 869216000612 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 869216000613 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869216000614 catalytic core [active] 869216000615 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869216000616 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869216000617 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216000618 dimer interface [polypeptide binding]; other site 869216000619 conserved gate region; other site 869216000620 putative PBP binding loops; other site 869216000621 ABC-ATPase subunit interface; other site 869216000623 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869216000624 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216000625 Walker A/P-loop; other site 869216000626 ATP binding site [chemical binding]; other site 869216000627 Q-loop/lid; other site 869216000628 ABC transporter signature motif; other site 869216000629 Walker B; other site 869216000630 D-loop; other site 869216000631 H-loop/switch region; other site 869216000632 TOBE domain; Region: TOBE_2; pfam08402 869216000633 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 869216000634 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 869216000635 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 869216000636 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869216000637 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869216000638 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 869216000639 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869216000640 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 869216000641 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869216000642 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 869216000643 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 869216000644 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869216000645 active site 869216000646 methionine cluster; other site 869216000647 phosphorylation site [posttranslational modification] 869216000648 metal binding site [ion binding]; metal-binding site 869216000649 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 869216000650 active site 869216000651 P-loop; other site 869216000652 phosphorylation site [posttranslational modification] 869216000653 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869216000654 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 869216000655 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 869216000656 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 869216000657 dimer interface [polypeptide binding]; other site 869216000658 active site 869216000659 glycine loop; other site 869216000660 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 869216000661 active site 869216000662 intersubunit interactions; other site 869216000663 catalytic residue [active] 869216000664 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 869216000665 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 869216000666 dimer interface [polypeptide binding]; other site 869216000667 active site 869216000668 metal binding site [ion binding]; metal-binding site 869216000669 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 869216000670 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 869216000671 HIGH motif; other site 869216000672 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869216000673 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869216000674 active site 869216000675 KMSKS motif; other site 869216000676 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 869216000677 tRNA binding surface [nucleotide binding]; other site 869216000678 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869216000679 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869216000680 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 869216000681 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869216000682 Coenzyme A binding pocket [chemical binding]; other site 869216000683 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 869216000684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216000685 Walker A motif; other site 869216000686 ATP binding site [chemical binding]; other site 869216000687 Walker B motif; other site 869216000688 arginine finger; other site 869216000689 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 869216000690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 869216000691 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 869216000692 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 869216000693 catalytic residue [active] 869216000694 putative FPP diphosphate binding site; other site 869216000695 putative FPP binding hydrophobic cleft; other site 869216000696 dimer interface [polypeptide binding]; other site 869216000697 putative IPP diphosphate binding site; other site 869216000698 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 869216000699 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 869216000700 RIP metalloprotease RseP; Region: TIGR00054 869216000701 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 869216000702 active site 869216000703 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 869216000704 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 869216000705 putative substrate binding region [chemical binding]; other site 869216000706 prolyl-tRNA synthetase; Provisional; Region: PRK09194 869216000707 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 869216000708 dimer interface [polypeptide binding]; other site 869216000709 motif 1; other site 869216000710 active site 869216000711 motif 2; other site 869216000712 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 869216000713 putative deacylase active site [active] 869216000714 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869216000715 active site 869216000716 motif 3; other site 869216000717 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 869216000718 anticodon binding site; other site 869216000719 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 869216000720 beta-galactosidase; Region: BGL; TIGR03356 869216000721 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 869216000722 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 869216000723 glutaminase active site [active] 869216000724 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 869216000725 dimer interface [polypeptide binding]; other site 869216000726 active site 869216000727 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 869216000728 dimer interface [polypeptide binding]; other site 869216000729 active site 869216000730 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 869216000731 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 869216000732 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869216000733 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 869216000734 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 869216000735 carbohydrate binding site [chemical binding]; other site 869216000736 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 869216000737 carbohydrate binding site [chemical binding]; other site 869216000738 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 869216000739 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 869216000740 Ca binding site [ion binding]; other site 869216000741 active site 869216000742 catalytic site [active] 869216000743 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 869216000744 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 869216000745 S17 interaction site [polypeptide binding]; other site 869216000746 S8 interaction site; other site 869216000747 16S rRNA interaction site [nucleotide binding]; other site 869216000748 streptomycin interaction site [chemical binding]; other site 869216000749 23S rRNA interaction site [nucleotide binding]; other site 869216000750 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 869216000751 30S ribosomal protein S7; Validated; Region: PRK05302 869216000752 elongation factor G; Reviewed; Region: PRK00007 869216000753 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 869216000754 G1 box; other site 869216000755 putative GEF interaction site [polypeptide binding]; other site 869216000756 GTP/Mg2+ binding site [chemical binding]; other site 869216000757 Switch I region; other site 869216000758 G2 box; other site 869216000759 G3 box; other site 869216000760 Switch II region; other site 869216000761 G4 box; other site 869216000762 G5 box; other site 869216000763 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 869216000764 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 869216000765 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 869216000766 DNA polymerase III PolC; Validated; Region: polC; PRK00448 869216000767 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 869216000768 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 869216000769 generic binding surface II; other site 869216000770 generic binding surface I; other site 869216000771 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 869216000772 active site 869216000773 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869216000774 active site 869216000775 catalytic site [active] 869216000776 substrate binding site [chemical binding]; other site 869216000777 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 869216000778 putative PHP Thumb interface [polypeptide binding]; other site 869216000779 active site 869216000780 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 869216000781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 869216000782 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 869216000783 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 869216000784 Predicted membrane protein [Function unknown]; Region: COG2261 869216000785 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869216000786 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869216000787 RNA binding surface [nucleotide binding]; other site 869216000788 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 869216000789 active site 869216000790 uracil binding [chemical binding]; other site 869216000791 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 869216000792 trimer interface [polypeptide binding]; other site 869216000793 active site 869216000794 G bulge; other site 869216000795 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869216000796 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 869216000797 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 869216000798 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869216000799 active pocket/dimerization site; other site 869216000800 active site 869216000801 phosphorylation site [posttranslational modification] 869216000802 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869216000803 active site 869216000804 phosphorylation site [posttranslational modification] 869216000805 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 869216000806 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 869216000807 NAD binding site [chemical binding]; other site 869216000808 substrate binding site [chemical binding]; other site 869216000809 catalytic Zn binding site [ion binding]; other site 869216000810 tetramer interface [polypeptide binding]; other site 869216000811 structural Zn binding site [ion binding]; other site 869216000812 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869216000813 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216000814 active site 869216000815 motif I; other site 869216000816 motif II; other site 869216000817 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 869216000818 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 869216000819 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 869216000820 dihydropteroate synthase; Region: DHPS; TIGR01496 869216000821 substrate binding pocket [chemical binding]; other site 869216000822 dimer interface [polypeptide binding]; other site 869216000823 inhibitor binding site; inhibition site 869216000824 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 869216000825 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869216000826 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869216000827 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 869216000828 homodecamer interface [polypeptide binding]; other site 869216000829 GTP cyclohydrolase I; Provisional; Region: PLN03044 869216000830 active site 869216000831 putative catalytic site residues [active] 869216000832 zinc binding site [ion binding]; other site 869216000833 GTP-CH-I/GFRP interaction surface; other site 869216000834 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 869216000835 homooctamer interface [polypeptide binding]; other site 869216000836 active site 869216000837 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 869216000838 catalytic center binding site [active] 869216000839 ATP binding site [chemical binding]; other site 869216000840 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 869216000841 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 869216000842 23S rRNA interface [nucleotide binding]; other site 869216000843 L3 interface [polypeptide binding]; other site 869216000844 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 869216000845 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869216000846 DNA binding site [nucleotide binding] 869216000847 active site 869216000848 Int/Topo IB signature motif; other site 869216000849 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 869216000850 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 869216000851 putative active site [active] 869216000852 putative catalytic site [active] 869216000853 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 869216000854 catalytic residues [active] 869216000855 dimer interface [polypeptide binding]; other site 869216000856 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 869216000857 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 869216000858 substrate binding site [chemical binding]; other site 869216000859 catalytic residues [active] 869216000861 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 869216000862 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 869216000863 active site 869216000864 intersubunit interface [polypeptide binding]; other site 869216000865 catalytic residue [active] 869216000866 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869216000867 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 869216000868 substrate binding site [chemical binding]; other site 869216000869 ATP binding site [chemical binding]; other site 869216000870 hypothetical protein; Provisional; Region: PRK09273 869216000871 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 869216000872 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 869216000873 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 869216000874 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 869216000875 NADP binding site [chemical binding]; other site 869216000876 homodimer interface [polypeptide binding]; other site 869216000877 active site 869216000878 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869216000879 active pocket/dimerization site; other site 869216000880 active site 869216000881 phosphorylation site [posttranslational modification] 869216000882 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 869216000883 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869216000884 active site 869216000885 phosphorylation site [posttranslational modification] 869216000886 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 869216000887 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869216000888 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 869216000889 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 869216000890 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869216000891 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869216000892 DNA binding site [nucleotide binding] 869216000893 domain linker motif; other site 869216000894 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 869216000895 putative dimerization interface [polypeptide binding]; other site 869216000896 putative ligand binding site [chemical binding]; other site 869216000897 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 869216000898 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216000899 non-specific DNA binding site [nucleotide binding]; other site 869216000900 salt bridge; other site 869216000901 sequence-specific DNA binding site [nucleotide binding]; other site 869216000902 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 869216000903 MraW methylase family; Region: Methyltransf_5; pfam01795 869216000904 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 869216000905 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 869216000906 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869216000907 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869216000908 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 869216000909 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 869216000910 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 869216000911 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 869216000912 Mg++ binding site [ion binding]; other site 869216000913 putative catalytic motif [active] 869216000914 putative substrate binding site [chemical binding]; other site 869216000915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216000916 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869216000917 Walker A motif; other site 869216000918 ATP binding site [chemical binding]; other site 869216000919 Walker B motif; other site 869216000920 arginine finger; other site 869216000921 UvrB/uvrC motif; Region: UVR; pfam02151 869216000922 MoxR-like ATPases [General function prediction only]; Region: COG0714 869216000923 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216000924 Walker A motif; other site 869216000925 ATP binding site [chemical binding]; other site 869216000926 Walker B motif; other site 869216000927 arginine finger; other site 869216000928 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869216000929 LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854 869216000930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 869216000931 hypothetical protein; Provisional; Region: PRK13663 869216000932 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 869216000933 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 869216000934 Ca binding site [ion binding]; other site 869216000935 active site 869216000936 catalytic site [active] 869216000940 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 869216000941 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 869216000942 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 869216000943 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 869216000944 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869216000945 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 869216000946 Bacterial sugar transferase; Region: Bac_transf; pfam02397 869216000947 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 869216000948 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 869216000949 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 869216000950 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869216000951 active site 869216000952 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869216000953 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869216000954 active site 869216000955 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 869216000956 WavE lipopolysaccharide synthesis; Region: WavE; pfam07507 869216000957 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869216000958 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 869216000959 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 869216000960 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 869216000961 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 869216000962 domain interaction interfaces [polypeptide binding]; other site 869216000963 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 869216000965 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869216000966 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869216000967 peptide binding site [polypeptide binding]; other site 869216000968 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869216000969 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 869216000970 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869216000971 Transglycosylase; Region: Transgly; pfam00912 869216000972 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 869216000973 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869216000974 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 869216000975 hypothetical protein; Provisional; Region: PRK13660 869216000976 cell division protein GpsB; Provisional; Region: PRK14127 869216000977 DivIVA domain; Region: DivI1A_domain; TIGR03544 869216000978 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 869216000979 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 869216000980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 869216000981 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 869216000982 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 869216000983 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 869216000984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869216000985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869216000986 active site 869216000987 phosphorylation site [posttranslational modification] 869216000988 intermolecular recognition site; other site 869216000989 dimerization interface [polypeptide binding]; other site 869216000990 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869216000991 DNA binding site [nucleotide binding] 869216000992 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869216000993 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869216000994 H+ Antiporter protein; Region: 2A0121; TIGR00900 869216000995 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 869216000996 active site 869216000997 zinc binding site [ion binding]; other site 869216000999 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 869216001000 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869216001001 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869216001002 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 869216001003 diphosphomevalonate decarboxylase; Region: PLN02407 869216001004 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 869216001005 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869216001006 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 869216001007 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 869216001008 homotetramer interface [polypeptide binding]; other site 869216001009 FMN binding site [chemical binding]; other site 869216001010 homodimer contacts [polypeptide binding]; other site 869216001011 putative active site [active] 869216001012 putative substrate binding site [chemical binding]; other site 869216001013 Predicted membrane protein [Function unknown]; Region: COG4758 869216001014 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 869216001015 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869216001016 Histidine kinase; Region: HisKA_3; pfam07730 869216001017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869216001018 ATP binding site [chemical binding]; other site 869216001019 Mg2+ binding site [ion binding]; other site 869216001020 G-X-G motif; other site 869216001021 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869216001022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869216001023 active site 869216001024 phosphorylation site [posttranslational modification] 869216001025 intermolecular recognition site; other site 869216001026 dimerization interface [polypeptide binding]; other site 869216001027 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869216001028 DNA binding residues [nucleotide binding] 869216001029 dimerization interface [polypeptide binding]; other site 869216001030 A new structural DNA glycosylase; Region: AlkD_like; cl11434 869216001031 A new structural DNA glycosylase; Region: AlkD_like; cl11434 869216001032 A new structural DNA glycosylase; Region: AlkD_like; cl11434 869216001033 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 869216001034 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869216001035 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216001036 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216001040 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 869216001041 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 869216001042 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 869216001043 active site 869216001044 P-loop; other site 869216001045 phosphorylation site [posttranslational modification] 869216001046 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 869216001047 active site 869216001048 P-loop; other site 869216001049 phosphorylation site [posttranslational modification] 869216001050 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869216001051 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869216001052 active site 869216001053 P-loop; other site 869216001054 phosphorylation site [posttranslational modification] 869216001055 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869216001056 active site 869216001057 phosphorylation site [posttranslational modification] 869216001058 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 869216001059 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 869216001060 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 869216001061 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 869216001062 trigger factor; Provisional; Region: tig; PRK01490 869216001063 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 869216001064 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 869216001065 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 869216001066 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 869216001067 DNA binding site [nucleotide binding] 869216001068 AAA domain; Region: AAA_30; pfam13604 869216001069 Family description; Region: UvrD_C_2; pfam13538 869216001070 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 869216001071 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 869216001072 Catalytic site [active] 869216001073 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 869216001074 ribonuclease HIII; Provisional; Region: PRK00996 869216001075 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 869216001076 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 869216001077 RNA/DNA hybrid binding site [nucleotide binding]; other site 869216001078 active site 869216001079 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 869216001080 Colicin V production protein; Region: Colicin_V; pfam02674 869216001081 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 869216001082 MutS domain III; Region: MutS_III; pfam05192 869216001083 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 869216001084 Walker A/P-loop; other site 869216001085 ATP binding site [chemical binding]; other site 869216001086 Q-loop/lid; other site 869216001087 ABC transporter signature motif; other site 869216001088 Walker B; other site 869216001089 D-loop; other site 869216001090 H-loop/switch region; other site 869216001091 Smr domain; Region: Smr; pfam01713 869216001092 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 869216001093 amino acid carrier protein; Region: agcS; TIGR00835 869216001094 Uncharacterized conserved protein [Function unknown]; Region: COG2128 869216001095 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 869216001096 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 869216001097 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 869216001098 gating phenylalanine in ion channel; other site 869216001099 seryl-tRNA synthetase; Provisional; Region: PRK05431 869216001100 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 869216001101 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 869216001102 dimer interface [polypeptide binding]; other site 869216001103 active site 869216001104 motif 1; other site 869216001105 motif 2; other site 869216001106 motif 3; other site 869216001107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 869216001108 aspartate kinase; Reviewed; Region: PRK09034 869216001109 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 869216001110 putative catalytic residues [active] 869216001111 putative nucleotide binding site [chemical binding]; other site 869216001112 putative aspartate binding site [chemical binding]; other site 869216001113 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 869216001114 allosteric regulatory residue; other site 869216001115 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 869216001116 enoyl-CoA hydratase; Provisional; Region: PRK07260 869216001117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 869216001118 substrate binding site [chemical binding]; other site 869216001119 oxyanion hole (OAH) forming residues; other site 869216001120 trimer interface [polypeptide binding]; other site 869216001121 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869216001122 MarR family; Region: MarR_2; pfam12802 869216001123 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 869216001124 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 869216001125 dimer interface [polypeptide binding]; other site 869216001126 active site 869216001127 CoA binding pocket [chemical binding]; other site 869216001128 acyl carrier protein; Provisional; Region: acpP; PRK00982 869216001129 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 869216001130 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 869216001131 FMN binding site [chemical binding]; other site 869216001132 substrate binding site [chemical binding]; other site 869216001133 putative catalytic residue [active] 869216001134 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 869216001135 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 869216001136 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 869216001137 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 869216001138 NAD(P) binding site [chemical binding]; other site 869216001139 homotetramer interface [polypeptide binding]; other site 869216001140 homodimer interface [polypeptide binding]; other site 869216001141 active site 869216001142 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 869216001143 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 869216001144 dimer interface [polypeptide binding]; other site 869216001145 active site 869216001146 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 869216001147 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 869216001148 carboxyltransferase (CT) interaction site; other site 869216001149 biotinylation site [posttranslational modification]; other site 869216001150 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 869216001151 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 869216001152 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869216001153 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869216001154 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 869216001155 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 869216001156 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 869216001157 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 869216001158 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 869216001159 CAAX protease self-immunity; Region: Abi; pfam02517 869216001160 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 869216001161 putative RNA binding site [nucleotide binding]; other site 869216001162 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 869216001163 elongation factor P; Validated; Region: PRK00529 869216001164 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 869216001165 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 869216001166 RNA binding site [nucleotide binding]; other site 869216001167 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 869216001168 RNA binding site [nucleotide binding]; other site 869216001169 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 869216001170 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 869216001171 GatB domain; Region: GatB_Yqey; pfam02637 869216001172 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 869216001173 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 869216001174 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 869216001175 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 869216001176 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 869216001177 G1 box; other site 869216001178 putative GEF interaction site [polypeptide binding]; other site 869216001179 GTP/Mg2+ binding site [chemical binding]; other site 869216001180 Switch I region; other site 869216001181 G2 box; other site 869216001182 G3 box; other site 869216001183 Switch II region; other site 869216001184 G4 box; other site 869216001185 G5 box; other site 869216001186 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 869216001188 Helix-turn-helix domain; Region: HTH_28; pfam13518 869216001189 Winged helix-turn helix; Region: HTH_29; pfam13551 869216001190 Homeodomain-like domain; Region: HTH_32; pfam13565 869216001191 Integrase core domain; Region: rve; pfam00665 869216001192 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 869216001193 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 869216001194 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 869216001195 DAK2 domain; Region: Dak2; pfam02734 869216001196 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 869216001197 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869216001198 PYR/PP interface [polypeptide binding]; other site 869216001199 dimer interface [polypeptide binding]; other site 869216001200 TPP binding site [chemical binding]; other site 869216001201 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869216001202 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 869216001203 TPP-binding site [chemical binding]; other site 869216001204 dimer interface [polypeptide binding]; other site 869216001205 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 869216001206 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 869216001207 putative valine binding site [chemical binding]; other site 869216001208 dimer interface [polypeptide binding]; other site 869216001209 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 869216001210 ketol-acid reductoisomerase; Provisional; Region: PRK05479 869216001211 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 869216001212 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 869216001214 threonine dehydratase; Validated; Region: PRK08639 869216001215 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 869216001216 tetramer interface [polypeptide binding]; other site 869216001217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869216001218 catalytic residue [active] 869216001219 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 869216001220 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869216001221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216001222 Walker A/P-loop; other site 869216001223 ATP binding site [chemical binding]; other site 869216001224 Q-loop/lid; other site 869216001225 ABC transporter signature motif; other site 869216001226 Walker B; other site 869216001227 D-loop; other site 869216001228 H-loop/switch region; other site 869216001229 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869216001230 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869216001231 substrate binding pocket [chemical binding]; other site 869216001232 membrane-bound complex binding site; other site 869216001233 hinge residues; other site 869216001234 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216001235 dimer interface [polypeptide binding]; other site 869216001236 conserved gate region; other site 869216001237 putative PBP binding loops; other site 869216001238 ABC-ATPase subunit interface; other site 869216001239 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 869216001241 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 869216001242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869216001243 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869216001244 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 869216001245 active site 869216001246 DNA polymerase IV; Validated; Region: PRK02406 869216001247 DNA binding site [nucleotide binding] 869216001248 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 869216001249 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 869216001250 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 869216001251 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 869216001252 active site 869216001253 P-loop; other site 869216001254 phosphorylation site [posttranslational modification] 869216001255 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 869216001256 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 869216001257 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 869216001258 TrkA-N domain; Region: TrkA_N; pfam02254 869216001259 TrkA-C domain; Region: TrkA_C; pfam02080 869216001260 TrkA-N domain; Region: TrkA_N; pfam02254 869216001261 TrkA-C domain; Region: TrkA_C; pfam02080 869216001262 Uncharacterized conserved protein [Function unknown]; Region: COG1912 869216001263 hypothetical protein; Provisional; Region: PRK13661 869216001264 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869216001265 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869216001266 Walker A/P-loop; other site 869216001267 ATP binding site [chemical binding]; other site 869216001268 Q-loop/lid; other site 869216001269 ABC transporter signature motif; other site 869216001270 Walker B; other site 869216001271 D-loop; other site 869216001272 H-loop/switch region; other site 869216001273 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 869216001274 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869216001275 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869216001276 Walker A/P-loop; other site 869216001277 ATP binding site [chemical binding]; other site 869216001278 Q-loop/lid; other site 869216001279 ABC transporter signature motif; other site 869216001280 Walker B; other site 869216001281 D-loop; other site 869216001282 H-loop/switch region; other site 869216001283 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869216001284 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 869216001285 Predicted membrane protein [Function unknown]; Region: COG3601 869216001286 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 869216001287 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869216001288 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 869216001289 active site 869216001290 ParB-like nuclease domain; Region: ParBc; cl02129 869216001291 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869216001292 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869216001293 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 869216001294 CTP synthetase; Validated; Region: pyrG; PRK05380 869216001295 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 869216001296 Catalytic site [active] 869216001297 active site 869216001298 UTP binding site [chemical binding]; other site 869216001299 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 869216001300 active site 869216001301 putative oxyanion hole; other site 869216001302 catalytic triad [active] 869216001303 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 869216001304 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 869216001305 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 869216001306 PhoU domain; Region: PhoU; pfam01895 869216001307 PhoU domain; Region: PhoU; pfam01895 869216001308 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869216001309 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 869216001310 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 869216001311 putative active site [active] 869216001312 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869216001313 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 869216001314 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 869216001315 G5 domain; Region: G5; pfam07501 869216001316 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 869216001317 Phosphoglycerate kinase; Region: PGK; pfam00162 869216001318 substrate binding site [chemical binding]; other site 869216001319 hinge regions; other site 869216001320 ADP binding site [chemical binding]; other site 869216001321 catalytic site [active] 869216001322 Predicted membrane protein [Function unknown]; Region: COG4129 869216001323 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 869216001324 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 869216001325 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 869216001326 DNA binding residues [nucleotide binding] 869216001327 putative dimer interface [polypeptide binding]; other site 869216001328 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 869216001329 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 869216001330 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 869216001331 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869216001332 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869216001333 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869216001334 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 869216001335 VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196 869216001336 Int/Topo IB signature motif; other site 869216001337 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869216001338 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869216001339 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869216001340 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 869216001341 HsdM N-terminal domain; Region: HsdM_N; pfam12161 869216001342 Methyltransferase domain; Region: Methyltransf_26; pfam13659 869216001343 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 869216001344 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 869216001345 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869216001346 ATP binding site [chemical binding]; other site 869216001347 putative Mg++ binding site [ion binding]; other site 869216001348 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 869216001349 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 869216001350 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 869216001351 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 869216001352 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 869216001353 dimer interface [polypeptide binding]; other site 869216001354 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 869216001355 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 869216001356 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 869216001357 nucleotide binding site [chemical binding]; other site 869216001358 NEF interaction site [polypeptide binding]; other site 869216001359 SBD interface [polypeptide binding]; other site 869216001360 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 869216001361 conserved cys residue [active] 869216001362 chaperone protein DnaJ; Provisional; Region: PRK14276 869216001363 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869216001364 HSP70 interaction site [polypeptide binding]; other site 869216001365 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 869216001366 substrate binding site [polypeptide binding]; other site 869216001367 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 869216001368 Zn binding sites [ion binding]; other site 869216001369 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 869216001370 substrate binding site [polypeptide binding]; other site 869216001371 dimer interface [polypeptide binding]; other site 869216001372 PIF1-like helicase; Region: PIF1; pfam05970 869216001373 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 869216001374 HIT family signature motif; other site 869216001375 catalytic residue [active] 869216001376 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 869216001377 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869216001378 Walker A/P-loop; other site 869216001379 ATP binding site [chemical binding]; other site 869216001380 Q-loop/lid; other site 869216001381 ABC transporter signature motif; other site 869216001382 Walker B; other site 869216001383 D-loop; other site 869216001384 H-loop/switch region; other site 869216001385 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 869216001386 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869216001387 LytTr DNA-binding domain; Region: LytTR; pfam04397 869216001388 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869216001389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869216001390 active site 869216001391 phosphorylation site [posttranslational modification] 869216001392 intermolecular recognition site; other site 869216001393 dimerization interface [polypeptide binding]; other site 869216001394 LytTr DNA-binding domain; Region: LytTR; pfam04397 869216001395 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869216001396 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 869216001397 ATP binding site [chemical binding]; other site 869216001398 Mg2+ binding site [ion binding]; other site 869216001399 G-X-G motif; other site 869216001400 COMC family; Region: ComC; pfam03047 869216001401 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 869216001402 HlyD family secretion protein; Region: HlyD_3; pfam13437 869216001403 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 869216001404 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 869216001405 putative active site [active] 869216001406 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869216001407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216001408 Walker A/P-loop; other site 869216001409 ATP binding site [chemical binding]; other site 869216001410 Q-loop/lid; other site 869216001411 ABC transporter signature motif; other site 869216001412 Walker B; other site 869216001413 D-loop; other site 869216001414 H-loop/switch region; other site 869216001415 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 869216001417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 869216001418 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869216001419 CAAX protease self-immunity; Region: Abi; pfam02517 869216001420 CAAX protease self-immunity; Region: Abi; pfam02517 869216001421 Phosphotransferase enzyme family; Region: APH; pfam01636 869216001422 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 869216001423 substrate binding site [chemical binding]; other site 869216001424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216001425 S-adenosylmethionine binding site [chemical binding]; other site 869216001426 ribosome maturation protein RimP; Reviewed; Region: PRK00092 869216001427 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 869216001428 putative oligomer interface [polypeptide binding]; other site 869216001429 putative RNA binding site [nucleotide binding]; other site 869216001430 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 869216001431 NusA N-terminal domain; Region: NusA_N; pfam08529 869216001432 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 869216001433 RNA binding site [nucleotide binding]; other site 869216001434 homodimer interface [polypeptide binding]; other site 869216001435 NusA-like KH domain; Region: KH_5; pfam13184 869216001436 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 869216001437 G-X-X-G motif; other site 869216001438 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 869216001439 putative RNA binding cleft [nucleotide binding]; other site 869216001440 hypothetical protein; Provisional; Region: PRK07283 869216001441 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 869216001442 translation initiation factor IF-2; Region: IF-2; TIGR00487 869216001443 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 869216001444 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 869216001445 G1 box; other site 869216001446 putative GEF interaction site [polypeptide binding]; other site 869216001447 GTP/Mg2+ binding site [chemical binding]; other site 869216001448 Switch I region; other site 869216001449 G2 box; other site 869216001450 G3 box; other site 869216001451 Switch II region; other site 869216001452 G4 box; other site 869216001453 G5 box; other site 869216001454 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 869216001455 Translation-initiation factor 2; Region: IF-2; pfam11987 869216001456 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 869216001457 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 869216001458 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 869216001459 Uncharacterized conserved protein [Function unknown]; Region: COG2461 869216001460 Family of unknown function (DUF438); Region: DUF438; pfam04282 869216001461 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 869216001462 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869216001463 putative active site [active] 869216001464 heme pocket [chemical binding]; other site 869216001465 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 869216001466 hypothetical protein; Provisional; Region: PRK07758 869216001468 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 869216001469 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869216001470 active site 869216001471 HIGH motif; other site 869216001472 nucleotide binding site [chemical binding]; other site 869216001473 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869216001474 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 869216001475 active site 869216001476 KMSKS motif; other site 869216001477 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 869216001478 tRNA binding surface [nucleotide binding]; other site 869216001479 anticodon binding site; other site 869216001480 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 869216001482 AAA domain; Region: AAA_21; pfam13304 869216001483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216001484 ABC transporter signature motif; other site 869216001485 Walker B; other site 869216001486 D-loop; other site 869216001487 H-loop/switch region; other site 869216001488 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 869216001489 Fic/DOC family; Region: Fic; pfam02661 869216001493 transcriptional antiterminator BglG; Provisional; Region: PRK09772 869216001494 CAT RNA binding domain; Region: CAT_RBD; smart01061 869216001495 PRD domain; Region: PRD; pfam00874 869216001496 PRD domain; Region: PRD; pfam00874 869216001497 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 869216001498 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869216001499 active site turn [active] 869216001500 phosphorylation site [posttranslational modification] 869216001501 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869216001502 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 869216001503 HPr interaction site; other site 869216001504 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869216001505 active site 869216001506 phosphorylation site [posttranslational modification] 869216001507 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 869216001508 beta-galactosidase; Region: BGL; TIGR03356 869216001509 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 869216001510 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 869216001511 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 869216001512 dimer interface [polypeptide binding]; other site 869216001513 motif 1; other site 869216001514 active site 869216001515 motif 2; other site 869216001516 motif 3; other site 869216001517 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869216001518 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869216001519 Coenzyme A binding pocket [chemical binding]; other site 869216001520 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 869216001521 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 869216001522 putative tRNA-binding site [nucleotide binding]; other site 869216001523 B3/4 domain; Region: B3_4; pfam03483 869216001524 tRNA synthetase B5 domain; Region: B5; smart00874 869216001525 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 869216001526 dimer interface [polypeptide binding]; other site 869216001527 motif 1; other site 869216001528 motif 3; other site 869216001529 motif 2; other site 869216001530 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 869216001531 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 869216001532 putative catalytic site [active] 869216001533 putative metal binding site [ion binding]; other site 869216001534 putative phosphate binding site [ion binding]; other site 869216001535 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 869216001536 Helix-turn-helix domain; Region: HTH_38; pfam13936 869216001537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216001538 non-specific DNA binding site [nucleotide binding]; other site 869216001539 salt bridge; other site 869216001540 sequence-specific DNA binding site [nucleotide binding]; other site 869216001541 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 869216001542 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 869216001543 THF binding site; other site 869216001544 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 869216001545 substrate binding site [chemical binding]; other site 869216001546 THF binding site; other site 869216001547 zinc-binding site [ion binding]; other site 869216001548 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 869216001549 FAD binding site [chemical binding]; other site 869216001550 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 869216001551 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 869216001552 RNase E interface [polypeptide binding]; other site 869216001553 trimer interface [polypeptide binding]; other site 869216001554 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 869216001555 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 869216001556 RNase E interface [polypeptide binding]; other site 869216001557 trimer interface [polypeptide binding]; other site 869216001558 active site 869216001559 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 869216001560 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 869216001561 RNA binding site [nucleotide binding]; other site 869216001562 domain interface; other site 869216001563 serine O-acetyltransferase; Region: cysE; TIGR01172 869216001564 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 869216001565 trimer interface [polypeptide binding]; other site 869216001566 active site 869216001567 substrate binding site [chemical binding]; other site 869216001568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869216001569 Coenzyme A binding pocket [chemical binding]; other site 869216001570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869216001571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869216001572 Coenzyme A binding pocket [chemical binding]; other site 869216001573 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 869216001574 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869216001575 active site 869216001576 HIGH motif; other site 869216001577 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869216001578 KMSKS motif; other site 869216001579 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 869216001580 tRNA binding surface [nucleotide binding]; other site 869216001581 anticodon binding site; other site 869216001582 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 869216001583 active site 869216001584 metal binding site [ion binding]; metal-binding site 869216001585 dimerization interface [polypeptide binding]; other site 869216001586 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 869216001587 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 869216001588 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 869216001589 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869216001590 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869216001591 FtsX-like permease family; Region: FtsX; pfam02687 869216001592 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869216001593 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869216001594 Walker A/P-loop; other site 869216001595 ATP binding site [chemical binding]; other site 869216001596 Q-loop/lid; other site 869216001597 ABC transporter signature motif; other site 869216001598 Walker B; other site 869216001599 D-loop; other site 869216001600 H-loop/switch region; other site 869216001601 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869216001602 FtsX-like permease family; Region: FtsX; pfam02687 869216001603 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869216001604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869216001605 active site 869216001606 phosphorylation site [posttranslational modification] 869216001607 intermolecular recognition site; other site 869216001608 dimerization interface [polypeptide binding]; other site 869216001609 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869216001610 DNA binding site [nucleotide binding] 869216001611 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869216001612 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869216001613 dimerization interface [polypeptide binding]; other site 869216001614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869216001615 dimer interface [polypeptide binding]; other site 869216001616 phosphorylation site [posttranslational modification] 869216001617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869216001618 ATP binding site [chemical binding]; other site 869216001619 Mg2+ binding site [ion binding]; other site 869216001620 G-X-G motif; other site 869216001621 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 869216001622 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 869216001623 intersubunit interface [polypeptide binding]; other site 869216001624 active site 869216001625 zinc binding site [ion binding]; other site 869216001626 Na+ binding site [ion binding]; other site 869216001627 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 869216001628 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 869216001629 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 869216001630 FAD binding pocket [chemical binding]; other site 869216001631 FAD binding motif [chemical binding]; other site 869216001632 phosphate binding motif [ion binding]; other site 869216001633 beta-alpha-beta structure motif; other site 869216001634 NAD binding pocket [chemical binding]; other site 869216001635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216001636 dimer interface [polypeptide binding]; other site 869216001637 conserved gate region; other site 869216001638 putative PBP binding loops; other site 869216001639 ABC-ATPase subunit interface; other site 869216001640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216001641 dimer interface [polypeptide binding]; other site 869216001642 conserved gate region; other site 869216001643 putative PBP binding loops; other site 869216001644 ABC-ATPase subunit interface; other site 869216001645 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869216001646 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869216001647 substrate binding pocket [chemical binding]; other site 869216001648 membrane-bound complex binding site; other site 869216001649 hinge residues; other site 869216001650 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869216001651 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869216001652 Walker A/P-loop; other site 869216001653 ATP binding site [chemical binding]; other site 869216001654 Q-loop/lid; other site 869216001655 ABC transporter signature motif; other site 869216001656 Walker B; other site 869216001657 D-loop; other site 869216001658 H-loop/switch region; other site 869216001659 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 869216001660 DHH family; Region: DHH; pfam01368 869216001661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 869216001662 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 869216001663 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869216001664 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 869216001665 Predicted esterase [General function prediction only]; Region: COG0627 869216001666 S-formylglutathione hydrolase; Region: PLN02442 869216001667 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 869216001668 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 869216001669 FemAB family; Region: FemAB; pfam02388 869216001670 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 869216001671 active site 869216001672 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 869216001673 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 869216001674 GIY-YIG motif/motif A; other site 869216001675 active site 869216001676 catalytic site [active] 869216001677 putative DNA binding site [nucleotide binding]; other site 869216001678 metal binding site [ion binding]; metal-binding site 869216001679 UvrB/uvrC motif; Region: UVR; pfam02151 869216001680 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 869216001681 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 869216001682 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869216001683 active site 869216001684 metal binding site [ion binding]; metal-binding site 869216001685 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869216001686 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869216001687 substrate binding pocket [chemical binding]; other site 869216001688 membrane-bound complex binding site; other site 869216001689 hinge residues; other site 869216001690 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 869216001691 dimer interface [polypeptide binding]; other site 869216001692 FMN binding site [chemical binding]; other site 869216001693 dipeptidase PepV; Reviewed; Region: PRK07318 869216001694 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 869216001695 active site 869216001696 metal binding site [ion binding]; metal-binding site 869216001697 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 869216001698 putative uracil binding site [chemical binding]; other site 869216001699 putative active site [active] 869216001700 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869216001701 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869216001702 active site residue [active] 869216001703 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 869216001704 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 869216001705 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 869216001706 putative oligomer interface [polypeptide binding]; other site 869216001707 putative active site [active] 869216001708 metal binding site [ion binding]; metal-binding site 869216001709 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 869216001710 nucleotide binding site/active site [active] 869216001711 HIT family signature motif; other site 869216001712 catalytic residue [active] 869216001713 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 869216001714 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 869216001715 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 869216001716 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 869216001717 23S rRNA interface [nucleotide binding]; other site 869216001718 L7/L12 interface [polypeptide binding]; other site 869216001719 putative thiostrepton binding site; other site 869216001720 L25 interface [polypeptide binding]; other site 869216001721 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 869216001722 mRNA/rRNA interface [nucleotide binding]; other site 869216001723 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 869216001724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216001725 Walker A/P-loop; other site 869216001726 ATP binding site [chemical binding]; other site 869216001727 Q-loop/lid; other site 869216001728 ABC transporter signature motif; other site 869216001729 Walker B; other site 869216001730 D-loop; other site 869216001731 H-loop/switch region; other site 869216001732 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 869216001733 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 869216001734 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 869216001735 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 869216001736 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869216001737 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 869216001738 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 869216001739 putative active site [active] 869216001740 catalytic triad [active] 869216001741 PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819 869216001742 PA/protease or protease-like domain interface [polypeptide binding]; other site 869216001743 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 869216001744 catalytic residues [active] 869216001745 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 869216001746 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869216001747 active site 869216001748 phosphorylation site [posttranslational modification] 869216001749 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 869216001750 active site 869216001751 P-loop; other site 869216001752 phosphorylation site [posttranslational modification] 869216001753 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 869216001754 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 869216001755 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 869216001756 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 869216001757 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 869216001758 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 869216001759 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869216001760 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869216001761 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869216001762 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869216001763 G5 domain; Region: G5; pfam07501 869216001764 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869216001765 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 869216001766 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869216001767 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869216001768 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 869216001769 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 869216001770 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 869216001771 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 869216001772 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 869216001773 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 869216001774 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 869216001775 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 869216001776 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 869216001777 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 869216001778 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869216001779 catalytic residues [active] 869216001780 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 869216001781 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 869216001782 SelR domain; Region: SelR; pfam01641 869216001783 Response regulator receiver domain; Region: Response_reg; pfam00072 869216001784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869216001785 active site 869216001786 phosphorylation site [posttranslational modification] 869216001787 intermolecular recognition site; other site 869216001788 dimerization interface [polypeptide binding]; other site 869216001789 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869216001790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869216001791 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869216001792 Cache domain; Region: Cache_1; pfam02743 869216001793 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869216001794 dimerization interface [polypeptide binding]; other site 869216001795 Histidine kinase; Region: His_kinase; pfam06580 869216001796 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869216001797 ATP binding site [chemical binding]; other site 869216001798 Mg2+ binding site [ion binding]; other site 869216001799 G-X-G motif; other site 869216001800 hypothetical protein; Provisional; Region: PRK13690 869216001801 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 869216001802 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 869216001803 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 869216001804 aminodeoxychorismate synthase; Provisional; Region: PRK07508 869216001805 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 869216001806 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 869216001807 substrate-cofactor binding pocket; other site 869216001808 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 869216001809 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869216001810 catalytic residue [active] 869216001811 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 869216001812 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869216001813 Excalibur calcium-binding domain; Region: Excalibur; smart00894 869216001814 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 869216001815 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 869216001816 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869216001817 nucleotide binding site [chemical binding]; other site 869216001818 thymidylate synthase; Reviewed; Region: thyA; PRK01827 869216001819 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 869216001820 dimerization interface [polypeptide binding]; other site 869216001821 active site 869216001822 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 869216001823 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 869216001824 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 869216001825 GTPases [General function prediction only]; Region: HflX; COG2262 869216001826 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 869216001827 HflX GTPase family; Region: HflX; cd01878 869216001828 G1 box; other site 869216001829 GTP/Mg2+ binding site [chemical binding]; other site 869216001830 Switch I region; other site 869216001831 G2 box; other site 869216001832 G3 box; other site 869216001833 Switch II region; other site 869216001834 G4 box; other site 869216001835 G5 box; other site 869216001836 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 869216001837 ribonuclease Z; Region: RNase_Z; TIGR02651 869216001838 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 869216001839 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869216001840 NAD(P) binding site [chemical binding]; other site 869216001841 active site 869216001842 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869216001843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869216001844 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869216001845 dimerization interface [polypeptide binding]; other site 869216001846 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 869216001847 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869216001848 active site residue [active] 869216001849 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869216001850 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 869216001851 RNA binding surface [nucleotide binding]; other site 869216001852 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 869216001853 active site 869216001854 uracil binding [chemical binding]; other site 869216001855 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 869216001856 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 869216001857 G1 box; other site 869216001858 putative GEF interaction site [polypeptide binding]; other site 869216001859 GTP/Mg2+ binding site [chemical binding]; other site 869216001860 Switch I region; other site 869216001861 G2 box; other site 869216001862 G3 box; other site 869216001863 Switch II region; other site 869216001864 G4 box; other site 869216001865 G5 box; other site 869216001866 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 869216001867 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 869216001868 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 869216001869 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683 869216001870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 869216001871 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 869216001872 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216001873 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869216001874 Walker A/P-loop; other site 869216001875 ATP binding site [chemical binding]; other site 869216001876 Q-loop/lid; other site 869216001877 ABC transporter signature motif; other site 869216001878 Walker B; other site 869216001879 D-loop; other site 869216001880 H-loop/switch region; other site 869216001881 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 869216001882 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 869216001883 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869216001884 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869216001885 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 869216001886 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 869216001887 homodimer interface [polypeptide binding]; other site 869216001888 active site 869216001889 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 869216001890 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 869216001891 Cell division protein FtsQ; Region: FtsQ; pfam03799 869216001892 Peptidase family M50; Region: Peptidase_M50; pfam02163 869216001894 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869216001895 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869216001896 Walker A/P-loop; other site 869216001897 ATP binding site [chemical binding]; other site 869216001898 Q-loop/lid; other site 869216001899 ABC transporter signature motif; other site 869216001900 Walker B; other site 869216001901 D-loop; other site 869216001902 H-loop/switch region; other site 869216001904 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 869216001905 active site 869216001906 dimer interface [polypeptide binding]; other site 869216001907 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869216001908 active site 869216001909 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869216001910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216001911 Walker A/P-loop; other site 869216001912 ATP binding site [chemical binding]; other site 869216001913 Q-loop/lid; other site 869216001914 ABC transporter signature motif; other site 869216001915 Walker B; other site 869216001916 D-loop; other site 869216001917 H-loop/switch region; other site 869216001918 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 869216001919 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869216001920 substrate binding pocket [chemical binding]; other site 869216001921 membrane-bound complex binding site; other site 869216001922 hinge residues; other site 869216001924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216001925 dimer interface [polypeptide binding]; other site 869216001926 conserved gate region; other site 869216001927 putative PBP binding loops; other site 869216001928 ABC-ATPase subunit interface; other site 869216001930 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 869216001931 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 869216001932 dimer interface [polypeptide binding]; other site 869216001933 putative anticodon binding site; other site 869216001934 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 869216001935 motif 1; other site 869216001936 active site 869216001937 motif 2; other site 869216001938 motif 3; other site 869216001939 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 869216001940 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 869216001941 teramer interface [polypeptide binding]; other site 869216001942 active site 869216001943 FMN binding site [chemical binding]; other site 869216001944 catalytic residues [active] 869216001945 Putative transcription activator [Transcription]; Region: TenA; COG0819 869216001946 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 869216001947 substrate binding site [chemical binding]; other site 869216001948 multimerization interface [polypeptide binding]; other site 869216001949 ATP binding site [chemical binding]; other site 869216001950 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 869216001951 thiamine phosphate binding site [chemical binding]; other site 869216001952 active site 869216001953 pyrophosphate binding site [ion binding]; other site 869216001954 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 869216001955 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869216001956 Walker A/P-loop; other site 869216001957 ATP binding site [chemical binding]; other site 869216001958 ABC transporter; Region: ABC_tran; pfam00005 869216001959 Q-loop/lid; other site 869216001960 ABC transporter signature motif; other site 869216001961 Walker B; other site 869216001962 D-loop; other site 869216001963 H-loop/switch region; other site 869216001964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216001965 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 869216001966 Walker A/P-loop; other site 869216001967 ATP binding site [chemical binding]; other site 869216001968 Q-loop/lid; other site 869216001969 ABC transporter signature motif; other site 869216001970 Walker B; other site 869216001971 D-loop; other site 869216001972 H-loop/switch region; other site 869216001973 Putative transcription activator [Transcription]; Region: TenA; COG0819 869216001974 Predicted membrane protein [Function unknown]; Region: COG4732 869216001975 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 869216001976 substrate binding site [chemical binding]; other site 869216001977 multimerization interface [polypeptide binding]; other site 869216001978 ATP binding site [chemical binding]; other site 869216001979 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 869216001980 thiamine phosphate binding site [chemical binding]; other site 869216001981 active site 869216001982 pyrophosphate binding site [ion binding]; other site 869216001983 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 869216001984 dimer interface [polypeptide binding]; other site 869216001985 substrate binding site [chemical binding]; other site 869216001986 ATP binding site [chemical binding]; other site 869216001987 Predicted transcriptional regulator [Transcription]; Region: COG3682 869216001988 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 869216001989 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 869216001990 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 869216001991 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 869216001992 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869216001993 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 869216001994 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 869216001995 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 869216001996 PYR/PP interface [polypeptide binding]; other site 869216001997 dimer interface [polypeptide binding]; other site 869216001998 tetramer interface [polypeptide binding]; other site 869216001999 TPP binding site [chemical binding]; other site 869216002000 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869216002001 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 869216002002 TPP-binding site [chemical binding]; other site 869216002003 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869216002004 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869216002005 active site 869216002007 Winged helix-turn helix; Region: HTH_33; pfam13592 869216002008 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 869216002009 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 869216002010 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 869216002012 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 869216002013 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 869216002014 dimer interface [polypeptide binding]; other site 869216002015 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 869216002016 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 869216002017 putative active site [active] 869216002018 nucleotide binding site [chemical binding]; other site 869216002019 nudix motif; other site 869216002020 putative metal binding site [ion binding]; other site 869216002021 HI0933-like protein; Region: HI0933_like; pfam03486 869216002022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 869216002023 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 869216002024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869216002025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869216002026 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 869216002027 catalytic motif [active] 869216002028 Zn binding site [ion binding]; other site 869216002029 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869216002030 active site 869216002031 Clp protease; Region: CLP_protease; pfam00574 869216002032 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 869216002033 oligomer interface [polypeptide binding]; other site 869216002034 active site residues [active] 869216002035 hypothetical protein; Provisional; Region: PRK02302 869216002036 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 869216002037 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 869216002038 putative ligand binding site [chemical binding]; other site 869216002039 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869216002040 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 869216002041 TM-ABC transporter signature motif; other site 869216002042 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 869216002043 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 869216002044 TM-ABC transporter signature motif; other site 869216002045 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 869216002046 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 869216002047 Walker A/P-loop; other site 869216002048 ATP binding site [chemical binding]; other site 869216002049 Q-loop/lid; other site 869216002050 ABC transporter signature motif; other site 869216002051 Walker B; other site 869216002052 D-loop; other site 869216002053 H-loop/switch region; other site 869216002054 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 869216002055 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 869216002056 Walker A/P-loop; other site 869216002057 ATP binding site [chemical binding]; other site 869216002058 Q-loop/lid; other site 869216002059 ABC transporter signature motif; other site 869216002060 Walker B; other site 869216002061 D-loop; other site 869216002062 H-loop/switch region; other site 869216002063 FOG: CBS domain [General function prediction only]; Region: COG0517 869216002064 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 869216002065 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 869216002066 PCRF domain; Region: PCRF; pfam03462 869216002067 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 869216002068 RF-1 domain; Region: RF-1; pfam00472 869216002069 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 869216002070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216002071 Walker A/P-loop; other site 869216002072 ATP binding site [chemical binding]; other site 869216002073 Q-loop/lid; other site 869216002074 ABC transporter signature motif; other site 869216002075 Walker B; other site 869216002076 D-loop; other site 869216002077 H-loop/switch region; other site 869216002078 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 869216002079 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 869216002080 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869216002081 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 869216002082 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869216002083 active site turn [active] 869216002084 phosphorylation site [posttranslational modification] 869216002085 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 869216002086 HPr interaction site; other site 869216002087 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869216002088 active site 869216002089 phosphorylation site [posttranslational modification] 869216002090 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 869216002091 putative catalytic site [active] 869216002092 putative metal binding site [ion binding]; other site 869216002093 putative phosphate binding site [ion binding]; other site 869216002094 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 869216002095 DEAD-like helicases superfamily; Region: DEXDc; smart00487 869216002096 ATP binding site [chemical binding]; other site 869216002097 Mg++ binding site [ion binding]; other site 869216002098 motif III; other site 869216002099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869216002100 nucleotide binding region [chemical binding]; other site 869216002101 ATP-binding site [chemical binding]; other site 869216002102 S-adenosylmethionine synthetase; Validated; Region: PRK05250 869216002103 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 869216002104 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 869216002105 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 869216002106 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 869216002107 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 869216002108 active site 869216002109 FMN binding site [chemical binding]; other site 869216002110 substrate binding site [chemical binding]; other site 869216002111 catalytic residues [active] 869216002112 homodimer interface [polypeptide binding]; other site 869216002113 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 869216002114 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 869216002115 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 869216002116 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 869216002117 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 869216002118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 869216002119 VanZ like family; Region: VanZ; pfam04892 869216002120 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869216002121 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869216002122 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869216002123 ABC transporter; Region: ABC_tran_2; pfam12848 869216002124 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869216002125 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 869216002126 active site 869216002127 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 869216002128 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 869216002129 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 869216002130 KH domain; Region: KH_4; pfam13083 869216002131 G-X-X-G motif; other site 869216002132 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 869216002133 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 869216002134 RimM N-terminal domain; Region: RimM; pfam01782 869216002135 PRC-barrel domain; Region: PRC; pfam05239 869216002136 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 869216002137 ATP cone domain; Region: ATP-cone; pfam03477 869216002138 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 869216002139 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 869216002140 glutathione reductase; Validated; Region: PRK06116 869216002141 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869216002142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869216002143 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869216002144 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 869216002145 HlyD family secretion protein; Region: HlyD_3; pfam13437 869216002146 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869216002147 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869216002148 Walker A/P-loop; other site 869216002149 ATP binding site [chemical binding]; other site 869216002150 Q-loop/lid; other site 869216002151 ABC transporter signature motif; other site 869216002152 Walker B; other site 869216002153 D-loop; other site 869216002154 H-loop/switch region; other site 869216002155 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869216002156 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869216002157 FtsX-like permease family; Region: FtsX; pfam02687 869216002158 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 869216002159 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 869216002160 active site 869216002161 HIGH motif; other site 869216002162 KMSKS motif; other site 869216002163 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 869216002164 tRNA binding surface [nucleotide binding]; other site 869216002165 anticodon binding site; other site 869216002166 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 869216002167 dimer interface [polypeptide binding]; other site 869216002168 putative tRNA-binding site [nucleotide binding]; other site 869216002169 Predicted transcriptional regulators [Transcription]; Region: COG1695 869216002170 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 869216002171 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869216002172 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869216002173 active site 869216002174 catalytic tetrad [active] 869216002175 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 869216002176 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 869216002177 classical (c) SDRs; Region: SDR_c; cd05233 869216002178 NAD(P) binding site [chemical binding]; other site 869216002179 active site 869216002180 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 869216002181 nudix motif; other site 869216002182 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 869216002183 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869216002184 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 869216002185 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 869216002186 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 869216002187 Zn binding site [ion binding]; other site 869216002188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869216002189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869216002190 active site 869216002191 phosphorylation site [posttranslational modification] 869216002192 intermolecular recognition site; other site 869216002193 dimerization interface [polypeptide binding]; other site 869216002194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869216002195 DNA binding site [nucleotide binding] 869216002196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869216002197 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869216002198 dimer interface [polypeptide binding]; other site 869216002199 phosphorylation site [posttranslational modification] 869216002200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869216002201 ATP binding site [chemical binding]; other site 869216002202 Mg2+ binding site [ion binding]; other site 869216002203 G-X-G motif; other site 869216002204 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 869216002205 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869216002206 Peptidase family U32; Region: Peptidase_U32; pfam01136 869216002207 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 869216002208 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869216002209 active site 869216002210 catalytic site [active] 869216002211 substrate binding site [chemical binding]; other site 869216002212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869216002213 ATP binding site [chemical binding]; other site 869216002214 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 869216002215 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 869216002216 DJ-1 family protein; Region: not_thiJ; TIGR01383 869216002217 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 869216002218 conserved cys residue [active] 869216002219 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 869216002220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216002221 motif II; other site 869216002222 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 869216002223 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869216002224 Mg2+ binding site [ion binding]; other site 869216002225 G-X-G motif; other site 869216002226 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 869216002227 anchoring element; other site 869216002228 dimer interface [polypeptide binding]; other site 869216002229 ATP binding site [chemical binding]; other site 869216002230 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 869216002231 active site 869216002232 putative metal-binding site [ion binding]; other site 869216002233 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 869216002234 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 869216002236 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 869216002237 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 869216002238 nudix motif; other site 869216002240 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 869216002241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216002242 Walker A motif; other site 869216002243 ATP binding site [chemical binding]; other site 869216002244 Walker B motif; other site 869216002245 arginine finger; other site 869216002246 UvrB/uvrC motif; Region: UVR; pfam02151 869216002247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216002248 Walker A motif; other site 869216002249 ATP binding site [chemical binding]; other site 869216002250 Walker B motif; other site 869216002251 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869216002252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 869216002253 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 869216002254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216002255 dimer interface [polypeptide binding]; other site 869216002256 conserved gate region; other site 869216002257 putative PBP binding loops; other site 869216002258 ABC-ATPase subunit interface; other site 869216002259 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869216002260 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869216002261 Walker A/P-loop; other site 869216002262 ATP binding site [chemical binding]; other site 869216002263 Q-loop/lid; other site 869216002264 ABC transporter signature motif; other site 869216002265 Walker B; other site 869216002266 D-loop; other site 869216002267 H-loop/switch region; other site 869216002268 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 869216002269 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 869216002270 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 869216002271 homodimer interface [polypeptide binding]; other site 869216002272 NADP binding site [chemical binding]; other site 869216002273 substrate binding site [chemical binding]; other site 869216002274 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 869216002275 putative substrate binding site [chemical binding]; other site 869216002276 putative ATP binding site [chemical binding]; other site 869216002277 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 869216002278 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869216002279 active site 869216002280 dimer interface [polypeptide binding]; other site 869216002281 phosphopentomutase; Provisional; Region: PRK05362 869216002282 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 869216002284 purine nucleoside phosphorylase; Provisional; Region: PRK08202 869216002286 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 869216002287 topology modulation protein; Provisional; Region: PRK07261 869216002288 AAA domain; Region: AAA_17; pfam13207 869216002289 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 869216002290 pantothenate kinase; Provisional; Region: PRK05439 869216002291 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 869216002292 ATP-binding site [chemical binding]; other site 869216002293 CoA-binding site [chemical binding]; other site 869216002294 Mg2+-binding site [ion binding]; other site 869216002296 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869216002297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216002298 S-adenosylmethionine binding site [chemical binding]; other site 869216002299 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 869216002300 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869216002301 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869216002302 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 869216002303 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 869216002304 intersubunit interface [polypeptide binding]; other site 869216002305 active site 869216002306 catalytic residue [active] 869216002307 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 869216002308 active site 869216002309 catalytic motif [active] 869216002310 Zn binding site [ion binding]; other site 869216002311 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 869216002312 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 869216002313 ligand binding site [chemical binding]; other site 869216002314 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 869216002315 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869216002316 Walker A/P-loop; other site 869216002317 ATP binding site [chemical binding]; other site 869216002318 Q-loop/lid; other site 869216002319 ABC transporter signature motif; other site 869216002320 Walker B; other site 869216002321 D-loop; other site 869216002322 H-loop/switch region; other site 869216002323 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869216002324 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869216002325 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 869216002326 TM-ABC transporter signature motif; other site 869216002327 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869216002328 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 869216002329 TM-ABC transporter signature motif; other site 869216002332 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 869216002333 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 869216002334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869216002335 Mg2+ binding site [ion binding]; other site 869216002336 G-X-G motif; other site 869216002337 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 869216002338 anchoring element; other site 869216002339 dimer interface [polypeptide binding]; other site 869216002340 ATP binding site [chemical binding]; other site 869216002341 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 869216002342 active site 869216002343 putative metal-binding site [ion binding]; other site 869216002344 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 869216002345 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 869216002346 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 869216002347 CAP-like domain; other site 869216002348 active site 869216002349 primary dimer interface [polypeptide binding]; other site 869216002350 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869216002351 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 869216002352 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 869216002353 homodimer interface [polypeptide binding]; other site 869216002354 substrate-cofactor binding pocket; other site 869216002355 catalytic residue [active] 869216002356 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 869216002357 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 869216002358 Predicted membrane protein [Function unknown]; Region: COG3819 869216002359 Predicted membrane protein [Function unknown]; Region: COG3817 869216002360 Protein of unknown function (DUF979); Region: DUF979; pfam06166 869216002361 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 869216002362 putative substrate binding pocket [chemical binding]; other site 869216002363 AC domain interface; other site 869216002364 catalytic triad [active] 869216002365 AB domain interface; other site 869216002366 interchain disulfide; other site 869216002367 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 869216002368 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 869216002369 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 869216002370 RNA binding site [nucleotide binding]; other site 869216002371 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 869216002372 RNA binding site [nucleotide binding]; other site 869216002373 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 869216002374 RNA binding site [nucleotide binding]; other site 869216002375 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 869216002376 RNA binding site [nucleotide binding]; other site 869216002378 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 869216002379 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 869216002380 GAF domain; Region: GAF_2; pfam13185 869216002381 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 869216002382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216002383 Walker A motif; other site 869216002384 ATP binding site [chemical binding]; other site 869216002385 Walker B motif; other site 869216002386 arginine finger; other site 869216002387 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 869216002388 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 869216002389 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 869216002390 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 869216002391 Walker A/P-loop; other site 869216002392 ATP binding site [chemical binding]; other site 869216002393 Q-loop/lid; other site 869216002394 ABC transporter signature motif; other site 869216002395 Walker B; other site 869216002396 D-loop; other site 869216002397 H-loop/switch region; other site 869216002398 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 869216002399 FeS assembly protein SufD; Region: sufD; TIGR01981 869216002400 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 869216002401 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 869216002402 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869216002403 catalytic residue [active] 869216002404 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 869216002405 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 869216002406 trimerization site [polypeptide binding]; other site 869216002407 active site 869216002408 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 869216002409 FeS assembly protein SufB; Region: sufB; TIGR01980 869216002410 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 869216002411 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 869216002412 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 869216002413 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 869216002414 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869216002415 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 869216002416 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 869216002417 TM2 domain; Region: TM2; pfam05154 869216002418 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869216002419 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 869216002420 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869216002421 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 869216002422 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 869216002423 putative substrate binding site [chemical binding]; other site 869216002424 putative ATP binding site [chemical binding]; other site 869216002425 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 869216002426 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869216002427 active site 869216002428 phosphorylation site [posttranslational modification] 869216002429 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 869216002430 active site 869216002431 P-loop; other site 869216002432 phosphorylation site [posttranslational modification] 869216002433 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 869216002434 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 869216002435 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 869216002436 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869216002437 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 869216002438 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 869216002439 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 869216002440 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 869216002441 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869216002442 catalytic residue [active] 869216002443 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 869216002444 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 869216002445 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 869216002446 Ligand Binding Site [chemical binding]; other site 869216002447 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 869216002448 Putative esterase; Region: Esterase; pfam00756 869216002449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 869216002450 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 869216002451 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 869216002452 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 869216002453 HsdM N-terminal domain; Region: HsdM_N; pfam12161 869216002454 Methyltransferase domain; Region: Methyltransf_26; pfam13659 869216002455 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869216002456 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869216002457 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 869216002458 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 869216002459 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 869216002460 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 869216002461 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 869216002462 active site 869216002463 catalytic residues [active] 869216002464 DNA binding site [nucleotide binding] 869216002465 Int/Topo IB signature motif; other site 869216002466 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869216002467 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869216002468 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 869216002469 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 869216002470 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 869216002471 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869216002472 ATP binding site [chemical binding]; other site 869216002473 putative Mg++ binding site [ion binding]; other site 869216002474 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 869216002475 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 869216002477 CAAX protease self-immunity; Region: Abi; pfam02517 869216002478 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 869216002479 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 869216002480 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 869216002481 putative active site [active] 869216002482 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 869216002483 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 869216002484 putative active site cavity [active] 869216002485 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 869216002486 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 869216002487 inhibitor site; inhibition site 869216002488 active site 869216002489 dimer interface [polypeptide binding]; other site 869216002490 catalytic residue [active] 869216002491 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 869216002492 Na binding site [ion binding]; other site 869216002493 Domain of unknown function (DUF386); Region: DUF386; pfam04074 869216002494 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 869216002495 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 869216002496 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869216002497 Asp-box motif; other site 869216002498 catalytic site [active] 869216002499 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869216002500 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869216002501 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869216002502 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869216002503 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869216002504 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 869216002505 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 869216002506 V-type ATP synthase subunit K; Validated; Region: PRK06558 869216002507 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 869216002508 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 869216002509 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 869216002510 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 869216002511 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 869216002512 V-type ATP synthase subunit F; Provisional; Region: PRK01395 869216002513 V-type ATP synthase subunit A; Provisional; Region: PRK04192 869216002514 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869216002515 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 869216002516 Walker A motif/ATP binding site; other site 869216002517 Walker B motif; other site 869216002518 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869216002519 V-type ATP synthase subunit B; Provisional; Region: PRK04196 869216002520 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869216002521 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 869216002522 Walker A motif homologous position; other site 869216002523 Walker B motif; other site 869216002524 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869216002525 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 869216002526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869216002527 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869216002528 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 869216002531 Arginine repressor [Transcription]; Region: ArgR; COG1438 869216002532 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869216002533 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869216002534 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 869216002535 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 869216002536 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 869216002537 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 869216002538 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 869216002539 active site 869216002540 PHP Thumb interface [polypeptide binding]; other site 869216002541 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 869216002542 generic binding surface II; other site 869216002543 generic binding surface I; other site 869216002544 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 869216002545 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 869216002546 active site 869216002547 ADP/pyrophosphate binding site [chemical binding]; other site 869216002548 dimerization interface [polypeptide binding]; other site 869216002549 allosteric effector site; other site 869216002550 fructose-1,6-bisphosphate binding site; other site 869216002551 pyruvate kinase; Provisional; Region: PRK05826 869216002552 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 869216002553 domain interfaces; other site 869216002554 active site 869216002556 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 869216002557 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 869216002558 Predicted membrane protein [Function unknown]; Region: COG3689 869216002559 Predicted permeases [General function prediction only]; Region: COG0701 869216002560 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869216002561 active site 869216002562 Exopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3955 869216002563 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 869216002564 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 869216002565 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 869216002566 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 869216002567 RNA binding site [nucleotide binding]; other site 869216002568 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 869216002569 hypothetical protein; Provisional; Region: PRK04351 869216002570 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 869216002571 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869216002572 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869216002573 Walker A/P-loop; other site 869216002574 ATP binding site [chemical binding]; other site 869216002575 Q-loop/lid; other site 869216002576 ABC transporter signature motif; other site 869216002577 Walker B; other site 869216002578 D-loop; other site 869216002579 H-loop/switch region; other site 869216002580 FtsX-like permease family; Region: FtsX; pfam02687 869216002581 disrupted by IS insertion 869216002582 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 869216002583 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 869216002584 homodimer interface [polypeptide binding]; other site 869216002585 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869216002586 catalytic residue [active] 869216002587 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 869216002588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 869216002589 Transposase; Region: DEDD_Tnp_IS110; pfam01548 869216002590 spermidine synthase; Provisional; Region: PRK00811 869216002591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216002592 S-adenosylmethionine binding site [chemical binding]; other site 869216002593 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 869216002594 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 869216002595 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 869216002596 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 869216002597 dimer interface [polypeptide binding]; other site 869216002598 active site 869216002599 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869216002600 catalytic residues [active] 869216002601 substrate binding site [chemical binding]; other site 869216002602 agmatine deiminase; Provisional; Region: PRK13551 869216002603 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 869216002604 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 869216002605 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 869216002606 putative active site; other site 869216002607 catalytic triad [active] 869216002608 putative dimer interface [polypeptide binding]; other site 869216002609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216002610 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869216002611 active site 869216002612 motif I; other site 869216002613 motif II; other site 869216002614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216002615 CAAX protease self-immunity; Region: Abi; pfam02517 869216002616 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869216002617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869216002618 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869216002619 dimerization interface [polypeptide binding]; other site 869216002620 lipoprotein signal peptidase; Provisional; Region: PRK14797 869216002621 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869216002622 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869216002623 RNA binding surface [nucleotide binding]; other site 869216002624 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869216002625 active site 869216002626 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 869216002627 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869216002628 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869216002629 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 869216002630 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 869216002631 nucleotide binding site [chemical binding]; other site 869216002632 homotetrameric interface [polypeptide binding]; other site 869216002633 putative phosphate binding site [ion binding]; other site 869216002634 putative allosteric binding site; other site 869216002635 PUA domain; Region: PUA; pfam01472 869216002636 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 869216002637 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 869216002638 putative catalytic cysteine [active] 869216002639 pyrroline-5-carboxylate reductase; Region: PLN02688 869216002640 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 869216002641 thymidylate kinase; Validated; Region: tmk; PRK00698 869216002642 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 869216002643 TMP-binding site; other site 869216002644 ATP-binding site [chemical binding]; other site 869216002645 DNA polymerase III subunit delta'; Validated; Region: PRK07276 869216002646 DNA polymerase III subunit delta'; Validated; Region: PRK08485 869216002647 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 869216002648 Predicted methyltransferases [General function prediction only]; Region: COG0313 869216002649 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 869216002650 putative SAM binding site [chemical binding]; other site 869216002651 putative homodimer interface [polypeptide binding]; other site 869216002652 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 869216002653 Glucose inhibited division protein A; Region: GIDA; pfam01134 869216002654 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 869216002655 putative nucleotide binding site [chemical binding]; other site 869216002656 uridine monophosphate binding site [chemical binding]; other site 869216002657 homohexameric interface [polypeptide binding]; other site 869216002658 ribosome recycling factor; Reviewed; Region: frr; PRK00083 869216002659 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 869216002660 hinge region; other site 869216002661 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 869216002662 S1 domain; Region: S1_2; pfam13509 869216002663 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 869216002664 hypothetical protein; Provisional; Region: PRK13672 869216002665 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 869216002666 PhoH-like protein; Region: PhoH; pfam02562 869216002667 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869216002668 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869216002669 SLBB domain; Region: SLBB; pfam10531 869216002670 comEA protein; Region: comE; TIGR01259 869216002671 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 869216002672 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 869216002673 Competence protein; Region: Competence; pfam03772 869216002674 CpXC protein; Region: CpXC; pfam14353 869216002675 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 869216002676 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 869216002677 catalytic residues [active] 869216002678 catalytic nucleophile [active] 869216002679 Recombinase; Region: Recombinase; pfam07508 869216002680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869216002681 H+ Antiporter protein; Region: 2A0121; TIGR00900 869216002682 putative substrate translocation pore; other site 869216002683 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869216002684 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869216002685 ABC transporter; Region: ABC_tran_2; pfam12848 869216002686 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869216002687 YolD-like protein; Region: YolD; pfam08863 869216002688 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 869216002689 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 869216002690 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 869216002691 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 869216002692 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 869216002693 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 869216002694 23S rRNA binding site [nucleotide binding]; other site 869216002695 L21 binding site [polypeptide binding]; other site 869216002696 L13 binding site [polypeptide binding]; other site 869216002697 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869216002698 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 869216002699 dimer interface [polypeptide binding]; other site 869216002700 active site 869216002701 metal binding site [ion binding]; metal-binding site 869216002702 glutathione binding site [chemical binding]; other site 869216002703 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 869216002704 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 869216002705 FAD binding pocket [chemical binding]; other site 869216002706 FAD binding motif [chemical binding]; other site 869216002707 phosphate binding motif [ion binding]; other site 869216002708 beta-alpha-beta structure motif; other site 869216002709 NAD binding pocket [chemical binding]; other site 869216002710 Iron coordination center [ion binding]; other site 869216002711 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 869216002712 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 869216002713 heterodimer interface [polypeptide binding]; other site 869216002714 active site 869216002715 FMN binding site [chemical binding]; other site 869216002716 homodimer interface [polypeptide binding]; other site 869216002717 substrate binding site [chemical binding]; other site 869216002718 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869216002719 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 869216002720 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 869216002721 Domain of unknown function (DUF814); Region: DUF814; pfam05670 869216002722 metal-binding heat shock protein; Provisional; Region: PRK00016 869216002723 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 869216002724 GTPase Era; Reviewed; Region: era; PRK00089 869216002725 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 869216002726 G1 box; other site 869216002727 GTP/Mg2+ binding site [chemical binding]; other site 869216002728 Switch I region; other site 869216002729 G2 box; other site 869216002730 Switch II region; other site 869216002731 G3 box; other site 869216002732 G4 box; other site 869216002733 G5 box; other site 869216002734 KH domain; Region: KH_2; pfam07650 869216002735 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 869216002736 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 869216002737 DNA binding site [nucleotide binding] 869216002738 catalytic residue [active] 869216002739 H2TH interface [polypeptide binding]; other site 869216002740 putative catalytic residues [active] 869216002741 turnover-facilitating residue; other site 869216002742 intercalation triad [nucleotide binding]; other site 869216002743 8OG recognition residue [nucleotide binding]; other site 869216002744 putative reading head residues; other site 869216002745 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 869216002746 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 869216002747 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 869216002748 dephospho-CoA kinase; Region: TIGR00152 869216002749 CoA-binding site [chemical binding]; other site 869216002750 ATP-binding [chemical binding]; other site 869216002751 drug efflux system protein MdtG; Provisional; Region: PRK09874 869216002752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869216002753 putative substrate translocation pore; other site 869216002754 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 869216002755 ribonuclease R; Region: RNase_R; TIGR02063 869216002756 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 869216002757 RNB domain; Region: RNB; pfam00773 869216002758 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 869216002759 RNA binding site [nucleotide binding]; other site 869216002760 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 869216002761 SmpB-tmRNA interface; other site 869216002762 tellurite resistance protein TehB; Provisional; Region: PRK12335 869216002763 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 869216002764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216002765 S-adenosylmethionine binding site [chemical binding]; other site 869216002766 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 869216002767 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 869216002768 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 869216002769 active site 869216002770 Zn binding site [ion binding]; other site 869216002771 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 869216002772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216002773 S-adenosylmethionine binding site [chemical binding]; other site 869216002776 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869216002777 catalytic core [active] 869216002778 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 869216002779 putative deacylase active site [active] 869216002780 Predicted membrane protein [Function unknown]; Region: COG2035 869216002781 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 869216002782 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 869216002783 active site 869216002784 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 869216002785 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 869216002786 Substrate binding site; other site 869216002787 Mg++ binding site; other site 869216002788 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 869216002789 active site 869216002790 substrate binding site [chemical binding]; other site 869216002791 CoA binding site [chemical binding]; other site 869216002792 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 869216002793 dimer interface [polypeptide binding]; other site 869216002794 ADP-ribose binding site [chemical binding]; other site 869216002795 active site 869216002796 nudix motif; other site 869216002797 metal binding site [ion binding]; metal-binding site 869216002798 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 869216002799 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 869216002800 MarR family; Region: MarR_2; cl17246 869216002801 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 869216002802 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869216002803 active site 869216002804 catalytic site [active] 869216002805 substrate binding site [chemical binding]; other site 869216002806 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 869216002807 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 869216002808 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 869216002809 putative active site [active] 869216002810 catalytic site [active] 869216002811 putative metal binding site [ion binding]; other site 869216002813 Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases; Region: TM_EGFR-like; cl17045 869216002814 dimer interface [polypeptide binding]; other site 869216002815 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 869216002816 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 869216002817 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 869216002818 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869216002819 catalytic residues [active] 869216002820 amino acid transporter; Region: 2A0306; TIGR00909 869216002821 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 869216002822 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869216002823 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 869216002824 metal binding site [ion binding]; metal-binding site 869216002825 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 869216002826 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869216002827 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869216002828 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869216002829 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 869216002830 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869216002831 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869216002832 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869216002833 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869216002836 pseudogene structure indicated by variation in homologue lengths and Frameplot 869216002837 peptidase T; Region: peptidase-T; TIGR01882 869216002838 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 869216002839 metal binding site [ion binding]; metal-binding site 869216002840 dimer interface [polypeptide binding]; other site 869216002841 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 869216002842 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 869216002843 C-terminal domain interface [polypeptide binding]; other site 869216002844 active site 869216002845 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 869216002846 active site 869216002847 N-terminal domain interface [polypeptide binding]; other site 869216002849 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869216002850 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 869216002851 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 869216002852 Predicted membrane protein [Function unknown]; Region: COG2246 869216002853 GtrA-like protein; Region: GtrA; pfam04138 869216002854 Predicted membrane protein [Function unknown]; Region: COG4708 869216002855 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 869216002856 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 869216002857 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 869216002858 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 869216002859 dimer interface [polypeptide binding]; other site 869216002860 active site 869216002861 catalytic residue [active] 869216002862 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 869216002863 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 869216002864 trmE is a tRNA modification GTPase; Region: trmE; cd04164 869216002865 G1 box; other site 869216002866 GTP/Mg2+ binding site [chemical binding]; other site 869216002867 Switch I region; other site 869216002868 G2 box; other site 869216002869 Switch II region; other site 869216002870 G3 box; other site 869216002871 G4 box; other site 869216002872 G5 box; other site 869216002873 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 869216002874 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 869216002875 active site 1 [active] 869216002876 dimer interface [polypeptide binding]; other site 869216002877 hexamer interface [polypeptide binding]; other site 869216002878 active site 2 [active] 869216002879 thymidine kinase; Provisional; Region: PRK04296 869216002880 peptide chain release factor 1; Validated; Region: prfA; PRK00591 869216002881 This domain is found in peptide chain release factors; Region: PCRF; smart00937 869216002882 RF-1 domain; Region: RF-1; pfam00472 869216002883 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 869216002884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216002885 S-adenosylmethionine binding site [chemical binding]; other site 869216002886 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 869216002887 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869216002888 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869216002889 Coenzyme A binding pocket [chemical binding]; other site 869216002890 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 869216002891 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 869216002892 dimer interface [polypeptide binding]; other site 869216002893 active site 869216002894 glycine-pyridoxal phosphate binding site [chemical binding]; other site 869216002895 folate binding site [chemical binding]; other site 869216002896 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 869216002897 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 869216002898 Lysozyme-like; Region: Lysozyme_like; pfam13702 869216002899 catalytic residue [active] 869216002900 Predicted secreted protein [Function unknown]; Region: COG4086 869216002901 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 869216002902 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 869216002903 TRAM domain; Region: TRAM; cl01282 869216002904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216002905 S-adenosylmethionine binding site [chemical binding]; other site 869216002906 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 869216002907 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 869216002908 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 869216002909 siderophore binding site; other site 869216002910 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 869216002911 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869216002912 ABC-ATPase subunit interface; other site 869216002913 dimer interface [polypeptide binding]; other site 869216002914 putative PBP binding regions; other site 869216002915 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869216002916 ABC-ATPase subunit interface; other site 869216002917 dimer interface [polypeptide binding]; other site 869216002918 putative PBP binding regions; other site 869216002919 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 869216002920 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869216002921 Walker A/P-loop; other site 869216002922 ATP binding site [chemical binding]; other site 869216002923 Q-loop/lid; other site 869216002924 ABC transporter signature motif; other site 869216002925 Walker B; other site 869216002926 D-loop; other site 869216002927 H-loop/switch region; other site 869216002929 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 869216002930 MobA/MobL family; Region: MobA_MobL; pfam03389 869216002931 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 869216002932 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 869216002933 catalytic residues [active] 869216002934 Recombinase; Region: Recombinase; pfam07508 869216002935 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 869216002937 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 869216002938 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 869216002940 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869216002941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216002942 non-specific DNA binding site [nucleotide binding]; other site 869216002943 salt bridge; other site 869216002944 sequence-specific DNA binding site [nucleotide binding]; other site 869216002945 Zeta toxin; Region: Zeta_toxin; pfam06414 869216002946 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 869216002947 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 869216002948 AAA domain; Region: AAA_21; pfam13304 869216002949 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216002950 ABC transporter signature motif; other site 869216002951 Walker B; other site 869216002952 D-loop; other site 869216002953 H-loop/switch region; other site 869216002955 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 869216002956 Helix-turn-helix domain; Region: HTH_38; pfam13936 869216002957 Integrase core domain; Region: rve; pfam00665 869216002958 Predicted membrane protein [Function unknown]; Region: COG1808 869216002959 DNA topoisomerase I; Validated; Region: PRK05582 869216002960 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 869216002961 active site 869216002962 interdomain interaction site; other site 869216002963 putative metal-binding site [ion binding]; other site 869216002964 nucleotide binding site [chemical binding]; other site 869216002965 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 869216002966 domain I; other site 869216002967 DNA binding groove [nucleotide binding] 869216002968 phosphate binding site [ion binding]; other site 869216002969 domain II; other site 869216002970 domain III; other site 869216002971 nucleotide binding site [chemical binding]; other site 869216002972 catalytic site [active] 869216002973 domain IV; other site 869216002974 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869216002975 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869216002976 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 869216002977 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 869216002978 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 869216002979 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 869216002981 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 869216002982 tartrate dehydrogenase; Region: TTC; TIGR02089 869216002983 Predicted membrane protein [Function unknown]; Region: COG3326 869216002984 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 869216002985 substrate binding site [chemical binding]; other site 869216002987 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 869216002988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216002989 Walker A motif; other site 869216002990 ATP binding site [chemical binding]; other site 869216002991 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 869216002992 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 869216002993 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869216002994 active site 869216002995 ribonuclease III; Reviewed; Region: rnc; PRK00102 869216002996 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 869216002997 dimerization interface [polypeptide binding]; other site 869216002998 active site 869216002999 metal binding site [ion binding]; metal-binding site 869216003000 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 869216003001 dsRNA binding site [nucleotide binding]; other site 869216003002 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 869216003003 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 869216003004 Walker A/P-loop; other site 869216003005 ATP binding site [chemical binding]; other site 869216003006 Q-loop/lid; other site 869216003007 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 869216003008 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 869216003009 ABC transporter signature motif; other site 869216003010 Walker B; other site 869216003011 D-loop; other site 869216003012 H-loop/switch region; other site 869216003013 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869216003014 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216003015 active site 869216003016 motif I; other site 869216003017 motif II; other site 869216003018 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 869216003019 sugar phosphate phosphatase; Provisional; Region: PRK10513 869216003020 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216003021 motif II; other site 869216003022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216003023 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 869216003024 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 869216003025 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 869216003026 P loop; other site 869216003027 GTP binding site [chemical binding]; other site 869216003028 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 869216003029 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 869216003030 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 869216003031 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869216003032 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869216003033 Walker A/P-loop; other site 869216003034 ATP binding site [chemical binding]; other site 869216003035 Q-loop/lid; other site 869216003036 ABC transporter signature motif; other site 869216003037 Walker B; other site 869216003038 D-loop; other site 869216003039 H-loop/switch region; other site 869216003040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869216003041 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869216003042 substrate binding pocket [chemical binding]; other site 869216003043 membrane-bound complex binding site; other site 869216003044 hinge residues; other site 869216003045 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869216003046 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869216003047 substrate binding pocket [chemical binding]; other site 869216003048 membrane-bound complex binding site; other site 869216003049 hinge residues; other site 869216003050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216003051 dimer interface [polypeptide binding]; other site 869216003052 conserved gate region; other site 869216003053 putative PBP binding loops; other site 869216003054 ABC-ATPase subunit interface; other site 869216003055 CAAX protease self-immunity; Region: Abi; pfam02517 869216003056 excinuclease ABC subunit B; Provisional; Region: PRK05298 869216003057 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869216003058 ATP binding site [chemical binding]; other site 869216003059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869216003060 nucleotide binding region [chemical binding]; other site 869216003061 ATP-binding site [chemical binding]; other site 869216003062 Ultra-violet resistance protein B; Region: UvrB; pfam12344 869216003063 UvrB/uvrC motif; Region: UVR; pfam02151 869216003064 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869216003065 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869216003066 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869216003067 Coenzyme A binding pocket [chemical binding]; other site 869216003068 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 869216003069 putative active site [active] 869216003070 nucleotide binding site [chemical binding]; other site 869216003071 nudix motif; other site 869216003072 putative metal binding site [ion binding]; other site 869216003073 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 869216003074 HTH domain; Region: HTH_11; pfam08279 869216003075 3H domain; Region: 3H; pfam02829 869216003076 Predicted membrane protein [Function unknown]; Region: COG4684 869216003077 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 869216003078 Flavoprotein; Region: Flavoprotein; pfam02441 869216003079 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 869216003080 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 869216003081 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 869216003082 Potassium binding sites [ion binding]; other site 869216003083 Cesium cation binding sites [ion binding]; other site 869216003084 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 869216003085 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869216003086 minor groove reading motif; other site 869216003087 helix-hairpin-helix signature motif; other site 869216003088 substrate binding pocket [chemical binding]; other site 869216003089 active site 869216003090 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 869216003091 DNA binding and oxoG recognition site [nucleotide binding] 869216003092 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869216003093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869216003094 active site 869216003095 phosphorylation site [posttranslational modification] 869216003096 intermolecular recognition site; other site 869216003097 dimerization interface [polypeptide binding]; other site 869216003098 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869216003099 DNA binding site [nucleotide binding] 869216003100 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 869216003101 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869216003102 putative active site [active] 869216003103 heme pocket [chemical binding]; other site 869216003104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869216003105 dimer interface [polypeptide binding]; other site 869216003106 phosphorylation site [posttranslational modification] 869216003107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869216003108 ATP binding site [chemical binding]; other site 869216003109 Mg2+ binding site [ion binding]; other site 869216003110 G-X-G motif; other site 869216003111 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 869216003112 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 869216003113 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 869216003114 Ion channel; Region: Ion_trans_2; pfam07885 869216003115 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 869216003116 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 869216003117 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869216003118 NAD binding site [chemical binding]; other site 869216003119 dimer interface [polypeptide binding]; other site 869216003120 substrate binding site [chemical binding]; other site 869216003121 DNA gyrase subunit A; Validated; Region: PRK05560 869216003122 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 869216003123 CAP-like domain; other site 869216003124 active site 869216003125 primary dimer interface [polypeptide binding]; other site 869216003126 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869216003127 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869216003128 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869216003129 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869216003130 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869216003131 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869216003132 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 869216003133 active site 869216003134 catalytic site [active] 869216003135 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 869216003137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 869216003138 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 869216003139 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 869216003140 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 869216003141 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 869216003142 RNA binding site [nucleotide binding]; other site 869216003143 active site 869216003144 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 869216003145 Enterocin A Immunity; Region: EntA_Immun; pfam08951 869216003146 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 869216003147 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 869216003148 Sugar specificity; other site 869216003149 Pyrimidine base specificity; other site 869216003150 ATP-binding site [chemical binding]; other site 869216003151 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 869216003152 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 869216003153 generic binding surface II; other site 869216003154 generic binding surface I; other site 869216003155 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 869216003156 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 869216003157 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 869216003158 substrate binding pocket [chemical binding]; other site 869216003159 chain length determination region; other site 869216003160 substrate-Mg2+ binding site; other site 869216003161 catalytic residues [active] 869216003162 aspartate-rich region 1; other site 869216003163 active site lid residues [active] 869216003164 aspartate-rich region 2; other site 869216003165 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 869216003166 S4 RNA-binding domain; Region: S4; smart00363 869216003167 RNA binding surface [nucleotide binding]; other site 869216003168 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 869216003169 Arginine repressor [Transcription]; Region: ArgR; COG1438 869216003170 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869216003171 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869216003172 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 869216003173 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 869216003174 Walker A/P-loop; other site 869216003175 ATP binding site [chemical binding]; other site 869216003176 Q-loop/lid; other site 869216003177 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 869216003178 ABC transporter signature motif; other site 869216003179 Walker B; other site 869216003180 D-loop; other site 869216003181 H-loop/switch region; other site 869216003182 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 869216003183 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869216003184 active site 869216003185 metal binding site [ion binding]; metal-binding site 869216003186 GTP-binding protein LepA; Provisional; Region: PRK05433 869216003187 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 869216003188 G1 box; other site 869216003189 putative GEF interaction site [polypeptide binding]; other site 869216003190 GTP/Mg2+ binding site [chemical binding]; other site 869216003191 Switch I region; other site 869216003192 G2 box; other site 869216003193 G3 box; other site 869216003194 Switch II region; other site 869216003195 G4 box; other site 869216003196 G5 box; other site 869216003197 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 869216003198 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 869216003199 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 869216003200 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869216003201 active site 869216003202 phosphorylation site [posttranslational modification] 869216003203 C-terminal truncation due to IS insertion 869216003204 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 869216003206 N-terminal truncation due to IS insertion 869216003207 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 869216003208 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 869216003209 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 869216003210 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 869216003211 putative substrate binding site [chemical binding]; other site 869216003212 putative ATP binding site [chemical binding]; other site 869216003213 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 869216003214 CAT RNA binding domain; Region: CAT_RBD; smart01061 869216003215 transcriptional antiterminator BglG; Provisional; Region: PRK09772 869216003216 PRD domain; Region: PRD; pfam00874 869216003217 PRD domain; Region: PRD; pfam00874 869216003218 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869216003219 methionine cluster; other site 869216003220 active site 869216003221 phosphorylation site [posttranslational modification] 869216003222 metal binding site [ion binding]; metal-binding site 869216003223 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 869216003224 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 869216003225 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 869216003226 active site 869216003227 P-loop; other site 869216003228 phosphorylation site [posttranslational modification] 869216003229 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 869216003230 beta-galactosidase; Region: BGL; TIGR03356 869216003231 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 869216003232 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869216003233 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 869216003234 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869216003235 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 869216003236 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869216003237 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869216003238 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 869216003239 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 869216003240 dimer interface [polypeptide binding]; other site 869216003241 putative radical transfer pathway; other site 869216003242 diiron center [ion binding]; other site 869216003243 tyrosyl radical; other site 869216003244 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 869216003245 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 869216003246 Class I ribonucleotide reductase; Region: RNR_I; cd01679 869216003247 active site 869216003248 dimer interface [polypeptide binding]; other site 869216003249 catalytic residues [active] 869216003250 effector binding site; other site 869216003251 R2 peptide binding site; other site 869216003252 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 869216003253 catalytic residues [active] 869216003254 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 869216003255 dimerization domain swap beta strand [polypeptide binding]; other site 869216003256 regulatory protein interface [polypeptide binding]; other site 869216003257 active site 869216003258 regulatory phosphorylation site [posttranslational modification]; other site 869216003259 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 869216003260 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 869216003261 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869216003262 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869216003263 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 869216003264 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869216003265 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869216003266 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869216003267 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 869216003268 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 869216003269 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216003270 motif II; other site 869216003271 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 869216003272 ligand binding site [chemical binding]; other site 869216003273 active site 869216003274 UGI interface [polypeptide binding]; other site 869216003275 catalytic site [active] 869216003276 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 869216003277 putative active site [active] 869216003278 nucleotide binding site [chemical binding]; other site 869216003279 nudix motif; other site 869216003280 putative metal binding site [ion binding]; other site 869216003281 dihydroorotase; Validated; Region: pyrC; PRK09357 869216003282 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 869216003283 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 869216003284 active site 869216003285 multidrug efflux protein; Reviewed; Region: PRK01766 869216003286 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 869216003287 cation binding site [ion binding]; other site 869216003288 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 869216003289 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 869216003290 tetramer interface [polypeptide binding]; other site 869216003291 TPP-binding site [chemical binding]; other site 869216003292 heterodimer interface [polypeptide binding]; other site 869216003293 phosphorylation loop region [posttranslational modification] 869216003294 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 869216003295 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 869216003296 alpha subunit interface [polypeptide binding]; other site 869216003297 TPP binding site [chemical binding]; other site 869216003298 heterodimer interface [polypeptide binding]; other site 869216003299 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869216003300 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 869216003301 e3 binding domain; Region: E3_binding; pfam02817 869216003302 e3 binding domain; Region: E3_binding; pfam02817 869216003303 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 869216003304 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869216003305 E3 interaction surface; other site 869216003306 lipoyl attachment site [posttranslational modification]; other site 869216003307 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 869216003308 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869216003309 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869216003310 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869216003311 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 869216003312 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 869216003313 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 869216003314 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 869216003315 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869216003316 active site 869216003317 DNA binding site [nucleotide binding] 869216003318 Int/Topo IB signature motif; other site 869216003319 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 869216003320 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 869216003321 Cl- selectivity filter; other site 869216003322 Cl- binding residues [ion binding]; other site 869216003323 pore gating glutamate residue; other site 869216003324 dimer interface [polypeptide binding]; other site 869216003325 H+/Cl- coupling transport residue; other site 869216003326 TrkA-C domain; Region: TrkA_C; pfam02080 869216003327 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 869216003328 RNA/DNA hybrid binding site [nucleotide binding]; other site 869216003329 active site 869216003330 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 869216003331 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 869216003332 GTP/Mg2+ binding site [chemical binding]; other site 869216003333 G4 box; other site 869216003334 G5 box; other site 869216003335 G1 box; other site 869216003336 Switch I region; other site 869216003337 G2 box; other site 869216003338 G3 box; other site 869216003339 Switch II region; other site 869216003340 G5 domain; Region: G5; pfam07501 869216003341 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 869216003342 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 869216003343 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869216003344 G5 domain; Region: G5; pfam07501 869216003345 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 869216003346 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 869216003347 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 869216003348 Part of AAA domain; Region: AAA_19; pfam13245 869216003349 Family description; Region: UvrD_C_2; pfam13538 869216003350 Family description; Region: UvrD_C_2; pfam13538 869216003351 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 869216003352 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 869216003353 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 869216003354 Transposase; Region: HTH_Tnp_IS630; pfam01710 869216003355 Helix-turn-helix domain; Region: HTH_28; pfam13518 869216003356 DDE superfamily endonuclease; Region: DDE_3; pfam13358 869216003357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 869216003358 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 869216003359 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869216003360 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869216003361 enolase; Provisional; Region: eno; PRK00077 869216003362 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 869216003363 dimer interface [polypeptide binding]; other site 869216003364 metal binding site [ion binding]; metal-binding site 869216003365 substrate binding pocket [chemical binding]; other site 869216003366 Uncharacterized conserved protein [Function unknown]; Region: COG5506 869216003367 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 869216003369 glycogen synthase; Provisional; Region: glgA; PRK00654 869216003370 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 869216003371 ADP-binding pocket [chemical binding]; other site 869216003372 homodimer interface [polypeptide binding]; other site 869216003373 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 869216003374 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869216003375 active site 869216003376 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 869216003377 dimer interface [polypeptide binding]; other site 869216003378 N-terminal domain interface [polypeptide binding]; other site 869216003379 sulfate 1 binding site; other site 869216003380 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 869216003381 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 869216003382 ligand binding site; other site 869216003383 oligomer interface; other site 869216003384 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 869216003385 dimer interface [polypeptide binding]; other site 869216003386 N-terminal domain interface [polypeptide binding]; other site 869216003387 sulfate 1 binding site; other site 869216003388 glycogen branching enzyme; Provisional; Region: PRK12313 869216003389 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 869216003390 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 869216003391 active site 869216003392 catalytic site [active] 869216003393 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 869216003394 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 869216003395 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 869216003396 tetrameric interface [polypeptide binding]; other site 869216003397 activator binding site; other site 869216003398 NADP binding site [chemical binding]; other site 869216003399 substrate binding site [chemical binding]; other site 869216003400 catalytic residues [active] 869216003401 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 869216003402 pullulanase, type I; Region: pulA_typeI; TIGR02104 869216003403 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 869216003404 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 869216003405 Ca binding site [ion binding]; other site 869216003406 active site 869216003407 catalytic site [active] 869216003408 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 869216003409 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 869216003410 nucleotide binding pocket [chemical binding]; other site 869216003411 K-X-D-G motif; other site 869216003412 catalytic site [active] 869216003413 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 869216003414 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 869216003415 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 869216003416 Dimer interface [polypeptide binding]; other site 869216003417 BRCT sequence motif; other site 869216003418 H+ Antiporter protein; Region: 2A0121; TIGR00900 869216003419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869216003420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216003421 non-specific DNA binding site [nucleotide binding]; other site 869216003422 salt bridge; other site 869216003423 sequence-specific DNA binding site [nucleotide binding]; other site 869216003424 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869216003425 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869216003426 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869216003427 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869216003428 ABC transporter; Region: ABC_tran_2; pfam12848 869216003429 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869216003430 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 869216003431 IHF dimer interface [polypeptide binding]; other site 869216003432 IHF - DNA interface [nucleotide binding]; other site 869216003433 EDD domain protein, DegV family; Region: DegV; TIGR00762 869216003434 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 869216003435 Uncharacterized conserved protein [Function unknown]; Region: COG1284 869216003436 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869216003437 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869216003438 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 869216003439 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 869216003440 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 869216003441 active site 869216003442 Riboflavin kinase; Region: Flavokinase; smart00904 869216003443 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 869216003444 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 869216003445 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 869216003446 Predicted membrane protein [Function unknown]; Region: COG3619 869216003447 hypothetical protein; Validated; Region: PRK00153 869216003448 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 869216003449 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869216003450 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869216003451 RNA binding surface [nucleotide binding]; other site 869216003452 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869216003453 active site 869216003454 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 869216003455 ATP-NAD kinase; Region: NAD_kinase; pfam01513 869216003456 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869216003457 synthetase active site [active] 869216003458 NTP binding site [chemical binding]; other site 869216003459 metal binding site [ion binding]; metal-binding site 869216003460 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 869216003461 putative active site [active] 869216003462 putative metal binding residues [ion binding]; other site 869216003463 signature motif; other site 869216003464 putative triphosphate binding site [ion binding]; other site 869216003465 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 869216003466 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 869216003467 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869216003468 active site 869216003469 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 869216003470 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 869216003471 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869216003472 catalytic residue [active] 869216003473 Putative amino acid metabolism; Region: DUF1831; pfam08866 869216003474 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 869216003475 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 869216003476 CoA binding domain; Region: CoA_binding; pfam02629 869216003477 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 869216003478 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 869216003479 catalytic triad [active] 869216003480 hypothetical protein; Reviewed; Region: PRK00024 869216003481 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 869216003482 MPN+ (JAMM) motif; other site 869216003483 Zinc-binding site [ion binding]; other site 869216003484 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 869216003485 Part of AAA domain; Region: AAA_19; pfam13245 869216003486 Family description; Region: UvrD_C_2; pfam13538 869216003488 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 869216003489 active site 869216003490 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 869216003491 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869216003492 DNA-binding site [nucleotide binding]; DNA binding site 869216003493 DRTGG domain; Region: DRTGG; pfam07085 869216003494 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 869216003495 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 869216003496 active site 2 [active] 869216003497 active site 1 [active] 869216003498 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869216003499 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869216003500 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 869216003501 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 869216003502 hinge; other site 869216003503 active site 869216003504 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 869216003505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869216003506 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869216003507 GTPase CgtA; Reviewed; Region: obgE; PRK12297 869216003508 GTP1/OBG; Region: GTP1_OBG; pfam01018 869216003509 Obg GTPase; Region: Obg; cd01898 869216003510 G1 box; other site 869216003511 GTP/Mg2+ binding site [chemical binding]; other site 869216003512 Switch I region; other site 869216003513 G2 box; other site 869216003514 G3 box; other site 869216003515 Switch II region; other site 869216003516 G4 box; other site 869216003517 G5 box; other site 869216003518 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 869216003519 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 869216003520 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 869216003521 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869216003522 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 869216003523 putative ADP-binding pocket [chemical binding]; other site 869216003524 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869216003525 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 869216003526 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 869216003527 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 869216003528 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 869216003529 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 869216003530 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869216003531 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869216003532 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869216003533 DNA binding residues [nucleotide binding] 869216003534 DNA primase; Validated; Region: dnaG; PRK05667 869216003535 CHC2 zinc finger; Region: zf-CHC2; pfam01807 869216003536 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 869216003537 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 869216003538 active site 869216003539 metal binding site [ion binding]; metal-binding site 869216003540 interdomain interaction site; other site 869216003541 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 869216003542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216003543 Walker A/P-loop; other site 869216003544 ATP binding site [chemical binding]; other site 869216003545 Q-loop/lid; other site 869216003546 ABC transporter signature motif; other site 869216003547 Walker B; other site 869216003548 D-loop; other site 869216003549 H-loop/switch region; other site 869216003550 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869216003551 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 869216003552 TM-ABC transporter signature motif; other site 869216003553 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 869216003554 zinc binding site [ion binding]; other site 869216003555 putative ligand binding site [chemical binding]; other site 869216003556 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 869216003557 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 869216003558 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 869216003560 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 869216003561 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 869216003562 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 869216003563 conserved cys residue [active] 869216003564 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 869216003565 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 869216003566 catalytic residues [active] 869216003567 catalytic nucleophile [active] 869216003568 Recombinase; Region: Recombinase; pfam07508 869216003569 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 869216003571 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 869216003572 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 869216003573 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 869216003574 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216003575 ABC transporter signature motif; other site 869216003576 Walker B; other site 869216003577 D-loop; other site 869216003578 H-loop/switch region; other site 869216003579 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216003580 Walker A/P-loop; other site 869216003581 ATP binding site [chemical binding]; other site 869216003582 Q-loop/lid; other site 869216003583 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 869216003584 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 869216003585 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 869216003586 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 869216003587 active site 869216003588 HIGH motif; other site 869216003589 KMSKS motif; other site 869216003590 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 869216003591 tRNA binding surface [nucleotide binding]; other site 869216003592 anticodon binding site; other site 869216003593 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 869216003594 Chloramphenicol acetyltransferase; Region: CAT; cl02008 869216003595 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 869216003596 Helix-turn-helix domain; Region: HTH_38; pfam13936 869216003597 Integrase core domain; Region: rve; pfam00665 869216003598 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 869216003599 DNA protecting protein DprA; Region: dprA; TIGR00732 869216003600 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 869216003601 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 869216003602 active site 869216003603 metal-binding site 869216003604 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 869216003605 Phosphotransferase enzyme family; Region: APH; pfam01636 869216003606 active site 869216003607 substrate binding site [chemical binding]; other site 869216003608 ATP binding site [chemical binding]; other site 869216003609 dimer interface [polypeptide binding]; other site 869216003610 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 869216003611 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869216003612 putative NAD(P) binding site [chemical binding]; other site 869216003613 putative catalytic Zn binding site [ion binding]; other site 869216003614 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 869216003615 substrate binding site; other site 869216003616 dimer interface; other site 869216003617 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869216003618 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 869216003619 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 869216003620 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 869216003621 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 869216003622 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869216003623 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869216003624 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 869216003625 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869216003626 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869216003627 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 869216003628 IMP binding site; other site 869216003629 dimer interface [polypeptide binding]; other site 869216003630 interdomain contacts; other site 869216003631 partial ornithine binding site; other site 869216003632 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 869216003633 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 869216003634 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 869216003635 catalytic site [active] 869216003636 subunit interface [polypeptide binding]; other site 869216003637 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 869216003638 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869216003639 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869216003640 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 869216003641 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869216003642 active site 869216003643 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 869216003644 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869216003645 minor groove reading motif; other site 869216003646 helix-hairpin-helix signature motif; other site 869216003647 substrate binding pocket [chemical binding]; other site 869216003648 active site 869216003649 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 869216003651 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869216003652 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869216003653 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869216003654 heat shock protein HtpX; Provisional; Region: PRK04897 869216003655 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 869216003656 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 869216003657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216003658 S-adenosylmethionine binding site [chemical binding]; other site 869216003659 uracil transporter; Provisional; Region: PRK10720 869216003660 signal recognition particle protein; Provisional; Region: PRK10867 869216003661 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 869216003662 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 869216003663 P loop; other site 869216003664 GTP binding site [chemical binding]; other site 869216003665 Signal peptide binding domain; Region: SRP_SPB; pfam02978 869216003666 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 869216003667 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 869216003668 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 869216003669 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 869216003670 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869216003671 Zn2+ binding site [ion binding]; other site 869216003672 Mg2+ binding site [ion binding]; other site 869216003673 sugar phosphate phosphatase; Provisional; Region: PRK10513 869216003674 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216003675 active site 869216003676 motif I; other site 869216003677 motif II; other site 869216003678 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 869216003679 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869216003680 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216003681 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216003682 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216003683 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869216003684 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216003685 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216003686 Caspase domain; Region: Peptidase_C14; pfam00656 869216003687 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869216003688 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216003689 non-specific DNA binding site [nucleotide binding]; other site 869216003690 salt bridge; other site 869216003691 sequence-specific DNA binding site [nucleotide binding]; other site 869216003692 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869216003694 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 869216003695 camphor resistance protein CrcB; Provisional; Region: PRK14229 869216003696 camphor resistance protein CrcB; Provisional; Region: PRK14221 869216003697 hypothetical protein; Provisional; Region: PRK07248 869216003698 flavodoxin; Validated; Region: PRK07308 869216003699 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 869216003700 DHH family; Region: DHH; pfam01368 869216003701 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 869216003702 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 869216003705 glutamate dehydrogenase; Provisional; Region: PRK09414 869216003706 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 869216003707 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 869216003708 NAD(P) binding site [chemical binding]; other site 869216003709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216003710 Walker A motif; other site 869216003711 ATP binding site [chemical binding]; other site 869216003712 Walker B motif; other site 869216003713 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 869216003714 core dimer interface [polypeptide binding]; other site 869216003715 L10 interface [polypeptide binding]; other site 869216003716 L11 interface [polypeptide binding]; other site 869216003717 putative EF-Tu interaction site [polypeptide binding]; other site 869216003718 putative EF-G interaction site [polypeptide binding]; other site 869216003719 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 869216003720 23S rRNA interface [nucleotide binding]; other site 869216003721 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 869216003722 chlorohydrolase; Validated; Region: PRK06687 869216003723 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 869216003724 active site 869216003725 putative substrate binding pocket [chemical binding]; other site 869216003726 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869216003727 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869216003728 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 869216003729 Walker A/P-loop; other site 869216003730 ATP binding site [chemical binding]; other site 869216003731 Q-loop/lid; other site 869216003732 ABC transporter signature motif; other site 869216003733 Walker B; other site 869216003734 D-loop; other site 869216003735 H-loop/switch region; other site 869216003736 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869216003737 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869216003738 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216003739 Walker A/P-loop; other site 869216003740 ATP binding site [chemical binding]; other site 869216003741 Q-loop/lid; other site 869216003742 ABC transporter signature motif; other site 869216003743 Walker B; other site 869216003744 D-loop; other site 869216003745 H-loop/switch region; other site 869216003746 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 869216003747 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 869216003748 SelR domain; Region: SelR; pfam01641 869216003749 homoserine kinase; Provisional; Region: PRK01212 869216003750 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869216003751 homoserine dehydrogenase; Provisional; Region: PRK06349 869216003752 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 869216003753 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 869216003754 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 869216003755 adaptor protein; Provisional; Region: PRK02315 869216003756 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 869216003757 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 869216003758 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869216003759 active site 869216003760 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869216003761 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 869216003762 putative ADP-binding pocket [chemical binding]; other site 869216003763 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 869216003764 Transcriptional regulator [Transcription]; Region: LytR; COG1316 869216003765 prephenate dehydratase; Provisional; Region: PRK11898 869216003766 Prephenate dehydratase; Region: PDT; pfam00800 869216003767 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 869216003768 putative L-Phe binding site [chemical binding]; other site 869216003769 shikimate kinase; Reviewed; Region: aroK; PRK00131 869216003770 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 869216003771 ADP binding site [chemical binding]; other site 869216003772 magnesium binding site [ion binding]; other site 869216003773 putative shikimate binding site; other site 869216003774 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 869216003775 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 869216003776 hinge; other site 869216003777 active site 869216003778 hypothetical protein; Provisional; Region: PRK13676 869216003779 prephenate dehydrogenase; Validated; Region: PRK06545 869216003780 prephenate dehydrogenase; Validated; Region: PRK08507 869216003781 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 869216003782 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 869216003783 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 869216003784 Tetramer interface [polypeptide binding]; other site 869216003785 active site 869216003786 FMN-binding site [chemical binding]; other site 869216003787 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 869216003788 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 869216003789 active site 869216003790 dimer interface [polypeptide binding]; other site 869216003791 metal binding site [ion binding]; metal-binding site 869216003792 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 869216003793 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 869216003794 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 869216003795 shikimate binding site; other site 869216003796 NAD(P) binding site [chemical binding]; other site 869216003797 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 869216003798 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 869216003799 active site 869216003800 catalytic residue [active] 869216003801 dimer interface [polypeptide binding]; other site 869216003802 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 869216003803 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 869216003804 putative RNA binding site [nucleotide binding]; other site 869216003805 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216003806 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 869216003807 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869216003808 Walker A/P-loop; other site 869216003809 ATP binding site [chemical binding]; other site 869216003810 Q-loop/lid; other site 869216003811 ABC transporter signature motif; other site 869216003812 Walker B; other site 869216003813 D-loop; other site 869216003814 H-loop/switch region; other site 869216003815 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 869216003816 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 869216003817 active site 869216003818 Na/Ca binding site [ion binding]; other site 869216003819 catalytic site [active] 869216003820 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 869216003821 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 869216003822 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 869216003823 motif 1; other site 869216003824 active site 869216003825 motif 2; other site 869216003826 motif 3; other site 869216003827 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 869216003828 DHHA1 domain; Region: DHHA1; pfam02272 869216003829 Uncharacterized conserved protein [Function unknown]; Region: COG4894 869216003830 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 869216003831 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 869216003832 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869216003833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216003834 dimer interface [polypeptide binding]; other site 869216003835 conserved gate region; other site 869216003836 putative PBP binding loops; other site 869216003837 ABC-ATPase subunit interface; other site 869216003838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216003839 dimer interface [polypeptide binding]; other site 869216003840 conserved gate region; other site 869216003841 putative PBP binding loops; other site 869216003842 ABC-ATPase subunit interface; other site 869216003843 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869216003844 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 869216003845 Walker A/P-loop; other site 869216003846 ATP binding site [chemical binding]; other site 869216003847 Q-loop/lid; other site 869216003848 ABC transporter signature motif; other site 869216003849 Walker B; other site 869216003850 D-loop; other site 869216003851 H-loop/switch region; other site 869216003852 TOBE domain; Region: TOBE_2; pfam08402 869216003853 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 869216003854 FAD binding domain; Region: FAD_binding_4; pfam01565 869216003855 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 869216003857 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 869216003858 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 869216003859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869216003860 DNA-binding site [nucleotide binding]; DNA binding site 869216003861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869216003862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869216003863 homodimer interface [polypeptide binding]; other site 869216003864 catalytic residue [active] 869216003865 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869216003866 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869216003867 substrate binding pocket [chemical binding]; other site 869216003868 membrane-bound complex binding site; other site 869216003869 hinge residues; other site 869216003870 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 869216003871 PhoU domain; Region: PhoU; pfam01895 869216003872 PhoU domain; Region: PhoU; pfam01895 869216003873 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 869216003874 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869216003875 Walker A/P-loop; other site 869216003876 ATP binding site [chemical binding]; other site 869216003877 Q-loop/lid; other site 869216003878 ABC transporter signature motif; other site 869216003879 Walker B; other site 869216003880 D-loop; other site 869216003881 H-loop/switch region; other site 869216003882 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 869216003883 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869216003884 Walker A/P-loop; other site 869216003885 ATP binding site [chemical binding]; other site 869216003886 Q-loop/lid; other site 869216003887 ABC transporter signature motif; other site 869216003888 Walker B; other site 869216003889 D-loop; other site 869216003890 H-loop/switch region; other site 869216003891 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 869216003892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216003893 dimer interface [polypeptide binding]; other site 869216003894 conserved gate region; other site 869216003895 putative PBP binding loops; other site 869216003896 ABC-ATPase subunit interface; other site 869216003897 sulfate transport protein; Provisional; Region: cysT; CHL00187 869216003898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216003899 dimer interface [polypeptide binding]; other site 869216003900 conserved gate region; other site 869216003901 putative PBP binding loops; other site 869216003902 ABC-ATPase subunit interface; other site 869216003903 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216003904 ABC-ATPase subunit interface; other site 869216003905 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 869216003906 phosphate binding protein; Region: ptsS_2; TIGR02136 869216003907 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 869216003908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216003909 S-adenosylmethionine binding site [chemical binding]; other site 869216003910 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 869216003911 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 869216003912 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 869216003913 active site 869216003914 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 869216003915 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 869216003916 ArsC family; Region: ArsC; pfam03960 869216003917 putative catalytic residues [active] 869216003918 thiol/disulfide switch; other site 869216003919 Predicted membrane protein [Function unknown]; Region: COG4478 869216003920 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 869216003921 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216003922 active site 869216003923 motif I; other site 869216003924 motif II; other site 869216003925 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216003926 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 869216003927 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869216003928 active site 869216003929 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869216003930 active site 869216003931 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 869216003932 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869216003933 FeS/SAM binding site; other site 869216003934 HemN C-terminal domain; Region: HemN_C; pfam06969 869216003935 YtxH-like protein; Region: YtxH; pfam12732 869216003936 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 869216003937 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 869216003938 HPr kinase/phosphorylase; Provisional; Region: PRK05428 869216003939 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 869216003940 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 869216003941 Hpr binding site; other site 869216003942 active site 869216003943 homohexamer subunit interaction site [polypeptide binding]; other site 869216003944 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 869216003945 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 869216003946 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 869216003947 active site 869216003948 trimer interface [polypeptide binding]; other site 869216003949 allosteric site; other site 869216003950 active site lid [active] 869216003951 hexamer (dimer of trimers) interface [polypeptide binding]; other site 869216003952 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 869216003953 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 869216003955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 869216003956 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869216003957 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 869216003958 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 869216003959 homodimer interface [polypeptide binding]; other site 869216003960 NAD binding pocket [chemical binding]; other site 869216003961 ATP binding pocket [chemical binding]; other site 869216003962 Mg binding site [ion binding]; other site 869216003963 active-site loop [active] 869216003964 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 869216003965 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 869216003966 active site 869216003967 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216003968 non-specific DNA binding site [nucleotide binding]; other site 869216003969 salt bridge; other site 869216003970 sequence-specific DNA binding site [nucleotide binding]; other site 869216003973 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869216003974 Peptidase family U32; Region: Peptidase_U32; pfam01136 869216003975 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869216003976 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869216003977 Peptidase family U32; Region: Peptidase_U32; pfam01136 869216003979 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 869216003980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216003981 S-adenosylmethionine binding site [chemical binding]; other site 869216003982 Helix-turn-helix domain; Region: HTH_18; pfam12833 869216003983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869216003984 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869216003985 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869216003986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216003987 Walker A/P-loop; other site 869216003988 ATP binding site [chemical binding]; other site 869216003989 Q-loop/lid; other site 869216003990 ABC transporter signature motif; other site 869216003991 Walker B; other site 869216003992 D-loop; other site 869216003993 H-loop/switch region; other site 869216003994 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869216003995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216003996 Walker A/P-loop; other site 869216003997 ATP binding site [chemical binding]; other site 869216003998 Q-loop/lid; other site 869216003999 ABC transporter signature motif; other site 869216004000 Walker B; other site 869216004001 D-loop; other site 869216004002 H-loop/switch region; other site 869216004003 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 869216004004 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869216004005 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869216004006 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869216004007 Walker A/P-loop; other site 869216004008 ATP binding site [chemical binding]; other site 869216004009 Q-loop/lid; other site 869216004010 ABC transporter signature motif; other site 869216004011 Walker B; other site 869216004012 D-loop; other site 869216004013 H-loop/switch region; other site 869216004014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216004015 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 869216004016 Walker A/P-loop; other site 869216004017 ATP binding site [chemical binding]; other site 869216004018 Q-loop/lid; other site 869216004019 ABC transporter signature motif; other site 869216004020 Walker B; other site 869216004021 D-loop; other site 869216004022 H-loop/switch region; other site 869216004027 GMP synthase; Reviewed; Region: guaA; PRK00074 869216004028 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 869216004029 AMP/PPi binding site [chemical binding]; other site 869216004030 candidate oxyanion hole; other site 869216004031 catalytic triad [active] 869216004032 potential glutamine specificity residues [chemical binding]; other site 869216004033 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 869216004034 ATP Binding subdomain [chemical binding]; other site 869216004035 Dimerization subdomain; other site 869216004036 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869216004037 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869216004038 DNA-binding site [nucleotide binding]; DNA binding site 869216004039 UTRA domain; Region: UTRA; pfam07702 869216004040 EamA-like transporter family; Region: EamA; pfam00892 869216004041 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 869216004042 Beta-lactamase; Region: Beta-lactamase; pfam00144 869216004043 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 869216004044 active site 869216004045 catalytic triad [active] 869216004046 oxyanion hole [active] 869216004047 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869216004048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216004049 active site 869216004050 motif I; other site 869216004051 motif II; other site 869216004052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216004054 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 869216004055 active site 869216004056 catalytic residues [active] 869216004057 metal binding site [ion binding]; metal-binding site 869216004058 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 869216004059 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 869216004060 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869216004061 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 869216004062 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869216004063 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869216004064 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 869216004065 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869216004066 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869216004067 Walker A/P-loop; other site 869216004068 ATP binding site [chemical binding]; other site 869216004069 Q-loop/lid; other site 869216004070 ABC transporter signature motif; other site 869216004071 Walker B; other site 869216004072 D-loop; other site 869216004073 H-loop/switch region; other site 869216004074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869216004075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216004076 ABC-ATPase subunit interface; other site 869216004077 putative PBP binding loops; other site 869216004078 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 869216004079 putative ArsC-like catalytic residues; other site 869216004080 putative TRX-like catalytic residues [active] 869216004081 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 869216004082 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 869216004083 DNA binding site [nucleotide binding] 869216004084 active site 869216004085 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869216004086 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 869216004087 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 869216004088 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 869216004089 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 869216004090 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869216004091 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869216004092 Walker A/P-loop; other site 869216004093 ATP binding site [chemical binding]; other site 869216004094 Q-loop/lid; other site 869216004095 ABC transporter signature motif; other site 869216004096 Walker B; other site 869216004097 D-loop; other site 869216004098 H-loop/switch region; other site 869216004099 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 869216004100 predicted active site [active] 869216004101 catalytic triad [active] 869216004102 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 869216004103 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 869216004104 active site 869216004105 multimer interface [polypeptide binding]; other site 869216004106 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 869216004107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869216004108 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869216004109 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 869216004110 ApbE family; Region: ApbE; pfam02424 869216004111 Predicted flavoprotein [General function prediction only]; Region: COG0431 869216004112 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869216004113 Predicted flavoprotein [General function prediction only]; Region: COG0431 869216004114 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869216004115 PAS domain; Region: PAS_10; pfam13596 869216004116 hypothetical protein; Provisional; Region: PRK02539 869216004117 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 869216004118 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 869216004119 DALR anticodon binding domain; Region: DALR_1; pfam05746 869216004120 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 869216004121 dimer interface [polypeptide binding]; other site 869216004122 motif 1; other site 869216004123 active site 869216004124 motif 2; other site 869216004125 motif 3; other site 869216004127 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869216004128 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869216004129 active site 869216004130 catalytic tetrad [active] 869216004131 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 869216004132 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 869216004133 NodB motif; other site 869216004134 active site 869216004135 catalytic site [active] 869216004136 Zn binding site [ion binding]; other site 869216004137 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869216004138 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869216004139 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 869216004140 DEAD-like helicases superfamily; Region: DEXDc; smart00487 869216004141 ATP binding site [chemical binding]; other site 869216004142 putative Mg++ binding site [ion binding]; other site 869216004143 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869216004144 nucleotide binding region [chemical binding]; other site 869216004145 ATP-binding site [chemical binding]; other site 869216004148 elongation factor Tu; Reviewed; Region: PRK00049 869216004149 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 869216004150 G1 box; other site 869216004151 GEF interaction site [polypeptide binding]; other site 869216004152 GTP/Mg2+ binding site [chemical binding]; other site 869216004153 Switch I region; other site 869216004154 G2 box; other site 869216004155 G3 box; other site 869216004156 Switch II region; other site 869216004157 G4 box; other site 869216004158 G5 box; other site 869216004159 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 869216004160 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 869216004161 Antibiotic Binding Site [chemical binding]; other site 869216004162 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 869216004163 amphipathic channel; other site 869216004164 Asn-Pro-Ala signature motifs; other site 869216004165 MucBP domain; Region: MucBP; pfam06458 869216004167 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 869216004168 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 869216004169 active site 869216004170 substrate binding site [chemical binding]; other site 869216004171 metal binding site [ion binding]; metal-binding site 869216004172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869216004173 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869216004174 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 869216004175 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869216004176 catalytic residues [active] 869216004177 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869216004178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869216004179 substrate binding pocket [chemical binding]; other site 869216004180 membrane-bound complex binding site; other site 869216004181 hinge residues; other site 869216004182 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869216004183 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216004184 Walker A/P-loop; other site 869216004185 ATP binding site [chemical binding]; other site 869216004186 Q-loop/lid; other site 869216004187 ABC transporter signature motif; other site 869216004188 Walker B; other site 869216004189 D-loop; other site 869216004190 H-loop/switch region; other site 869216004191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216004192 dimer interface [polypeptide binding]; other site 869216004193 conserved gate region; other site 869216004194 putative PBP binding loops; other site 869216004195 ABC-ATPase subunit interface; other site 869216004196 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 869216004197 TPR motif; other site 869216004198 binding surface 869216004199 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869216004200 binding surface 869216004201 TPR motif; other site 869216004202 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 869216004203 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869216004204 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 869216004205 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 869216004206 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 869216004207 gamma subunit interface [polypeptide binding]; other site 869216004208 epsilon subunit interface [polypeptide binding]; other site 869216004209 LBP interface [polypeptide binding]; other site 869216004210 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 869216004211 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869216004212 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 869216004213 alpha subunit interaction interface [polypeptide binding]; other site 869216004214 Walker A motif; other site 869216004215 ATP binding site [chemical binding]; other site 869216004216 Walker B motif; other site 869216004217 inhibitor binding site; inhibition site 869216004218 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869216004219 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 869216004220 core domain interface [polypeptide binding]; other site 869216004221 delta subunit interface [polypeptide binding]; other site 869216004222 epsilon subunit interface [polypeptide binding]; other site 869216004223 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 869216004224 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869216004225 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 869216004226 beta subunit interaction interface [polypeptide binding]; other site 869216004227 Walker A motif; other site 869216004228 ATP binding site [chemical binding]; other site 869216004229 Walker B motif; other site 869216004230 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869216004231 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 869216004232 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 869216004233 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 869216004234 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 869216004235 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 869216004236 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 869216004237 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 869216004239 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869216004240 Coenzyme A binding pocket [chemical binding]; other site 869216004241 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 869216004242 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 869216004243 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 869216004244 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 869216004245 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 869216004246 dimerization interface [polypeptide binding]; other site 869216004247 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 869216004248 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869216004249 Coenzyme A binding pocket [chemical binding]; other site 869216004250 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869216004251 Coenzyme A binding pocket [chemical binding]; other site 869216004252 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 869216004253 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869216004254 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869216004255 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869216004256 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 869216004257 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 869216004258 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869216004259 ATP binding site [chemical binding]; other site 869216004260 putative Mg++ binding site [ion binding]; other site 869216004261 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869216004262 nucleotide binding region [chemical binding]; other site 869216004263 ATP-binding site [chemical binding]; other site 869216004264 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 869216004265 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869216004266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869216004267 homodimer interface [polypeptide binding]; other site 869216004268 catalytic residue [active] 869216004269 cystathionine gamma-synthase; Reviewed; Region: PRK07269 869216004270 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 869216004271 homodimer interface [polypeptide binding]; other site 869216004272 substrate-cofactor binding pocket; other site 869216004273 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869216004274 catalytic residue [active] 869216004276 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869216004277 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869216004278 peptide binding site [polypeptide binding]; other site 869216004279 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869216004280 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 869216004281 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 869216004282 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869216004283 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869216004284 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869216004285 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 869216004286 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 869216004287 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 869216004288 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 869216004289 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 869216004290 DHH family; Region: DHH; pfam01368 869216004291 DHHA2 domain; Region: DHHA2; pfam02833 869216004292 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 869216004293 GIY-YIG motif/motif A; other site 869216004294 putative active site [active] 869216004295 putative metal binding site [ion binding]; other site 869216004296 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 869216004297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216004298 S-adenosylmethionine binding site [chemical binding]; other site 869216004299 hypothetical protein; Provisional; Region: PRK07252 869216004300 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 869216004301 RNA binding site [nucleotide binding]; other site 869216004302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216004303 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869216004304 active site 869216004305 motif I; other site 869216004306 motif II; other site 869216004307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216004308 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 869216004309 active site 869216004310 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 869216004311 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869216004312 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869216004313 dimer interface [polypeptide binding]; other site 869216004314 ssDNA binding site [nucleotide binding]; other site 869216004315 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869216004316 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 869216004317 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 869216004318 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 869216004319 putative dimer interface [polypeptide binding]; other site 869216004320 putative anticodon binding site; other site 869216004321 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 869216004322 homodimer interface [polypeptide binding]; other site 869216004323 motif 1; other site 869216004324 motif 2; other site 869216004325 active site 869216004326 motif 3; other site 869216004327 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 869216004328 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869216004329 aspartate aminotransferase; Provisional; Region: PRK05764 869216004330 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869216004331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869216004332 homodimer interface [polypeptide binding]; other site 869216004333 catalytic residue [active] 869216004334 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 869216004335 Predicted flavoprotein [General function prediction only]; Region: COG0431 869216004336 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869216004337 hypothetical protein; Validated; Region: PRK02101 869216004338 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 869216004339 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 869216004340 active site 869216004341 catalytic residues [active] 869216004342 metal binding site [ion binding]; metal-binding site 869216004343 putative S-transferase; Provisional; Region: PRK11752 869216004344 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 869216004345 C-terminal domain interface [polypeptide binding]; other site 869216004346 GSH binding site (G-site) [chemical binding]; other site 869216004347 dimer interface [polypeptide binding]; other site 869216004348 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 869216004349 N-terminal domain interface [polypeptide binding]; other site 869216004350 dimer interface [polypeptide binding]; other site 869216004351 substrate binding pocket (H-site) [chemical binding]; other site 869216004352 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 869216004353 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 869216004354 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869216004355 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 869216004356 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 869216004357 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 869216004358 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 869216004359 Cation efflux family; Region: Cation_efflux; pfam01545 869216004360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 869216004361 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869216004362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216004363 Walker A/P-loop; other site 869216004364 ATP binding site [chemical binding]; other site 869216004365 Q-loop/lid; other site 869216004366 ABC transporter signature motif; other site 869216004367 Walker B; other site 869216004368 D-loop; other site 869216004369 H-loop/switch region; other site 869216004370 ABC transporter; Region: ABC_tran_2; pfam12848 869216004371 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869216004372 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 869216004373 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 869216004374 active site 869216004375 NTP binding site [chemical binding]; other site 869216004376 metal binding triad [ion binding]; metal-binding site 869216004377 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 869216004378 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 869216004379 dihydrodipicolinate reductase; Provisional; Region: PRK00048 869216004380 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 869216004381 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 869216004382 EDD domain protein, DegV family; Region: DegV; TIGR00762 869216004383 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 869216004384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 869216004385 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 869216004386 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 869216004387 active site 869216004388 substrate binding site [chemical binding]; other site 869216004389 metal binding site [ion binding]; metal-binding site 869216004390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 869216004391 YbbR-like protein; Region: YbbR; pfam07949 869216004392 Uncharacterized conserved protein [Function unknown]; Region: COG1624 869216004393 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 869216004394 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 869216004395 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869216004396 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869216004397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 869216004398 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 869216004399 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 869216004400 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 869216004401 phosphate binding site [ion binding]; other site 869216004402 dimer interface [polypeptide binding]; other site 869216004403 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 869216004404 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 869216004405 homotrimer interaction site [polypeptide binding]; other site 869216004406 putative active site [active] 869216004407 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 869216004408 G1 box; other site 869216004409 GTP/Mg2+ binding site [chemical binding]; other site 869216004410 Switch I region; other site 869216004411 G2 box; other site 869216004412 G3 box; other site 869216004413 Switch II region; other site 869216004414 G4 box; other site 869216004415 G5 box; other site 869216004416 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 869216004417 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 869216004418 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216004419 Walker A motif; other site 869216004420 ATP binding site [chemical binding]; other site 869216004421 Walker B motif; other site 869216004422 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869216004423 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 869216004424 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 869216004425 folate binding site [chemical binding]; other site 869216004426 NADP+ binding site [chemical binding]; other site 869216004427 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 869216004428 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 869216004429 dimerization interface [polypeptide binding]; other site 869216004430 DPS ferroxidase diiron center [ion binding]; other site 869216004431 ion pore; other site 869216004432 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869216004433 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 869216004434 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 869216004435 active site 869216004436 triosephosphate isomerase; Provisional; Region: PRK14567 869216004437 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 869216004438 substrate binding site [chemical binding]; other site 869216004439 dimer interface [polypeptide binding]; other site 869216004440 catalytic triad [active] 869216004441 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 869216004442 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 869216004443 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 869216004444 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 869216004445 proposed active site lysine [active] 869216004446 conserved cys residue [active] 869216004447 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869216004448 active site 869216004449 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869216004450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216004451 S-adenosylmethionine binding site [chemical binding]; other site 869216004452 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 869216004453 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 869216004454 Walker A/P-loop; other site 869216004455 ATP binding site [chemical binding]; other site 869216004456 Q-loop/lid; other site 869216004457 ABC transporter signature motif; other site 869216004458 Walker B; other site 869216004459 D-loop; other site 869216004460 H-loop/switch region; other site 869216004461 TOBE domain; Region: TOBE_2; pfam08402 869216004462 Isochorismatase family; Region: Isochorismatase; pfam00857 869216004463 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 869216004464 catalytic triad [active] 869216004465 conserved cis-peptide bond; other site 869216004466 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 869216004467 CodY GAF-like domain; Region: CodY; pfam06018 869216004468 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869216004469 putative DNA binding site [nucleotide binding]; other site 869216004470 putative Zn2+ binding site [ion binding]; other site 869216004471 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 869216004472 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 869216004473 ATP binding site [chemical binding]; other site 869216004474 Mg++ binding site [ion binding]; other site 869216004475 motif III; other site 869216004476 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869216004477 nucleotide binding region [chemical binding]; other site 869216004478 ATP-binding site [chemical binding]; other site 869216004479 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 869216004480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869216004481 putative substrate translocation pore; other site 869216004482 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 869216004483 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 869216004484 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869216004485 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869216004486 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 869216004487 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869216004488 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 869216004489 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 869216004490 catalytic triad [active] 869216004491 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 869216004492 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 869216004493 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 869216004494 active site 869216004495 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869216004498 Predicted membrane protein [Function unknown]; Region: COG4720 869216004499 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 869216004500 dimer interface [polypeptide binding]; other site 869216004501 substrate binding site [chemical binding]; other site 869216004502 ATP binding site [chemical binding]; other site 869216004503 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 869216004504 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 869216004505 dimerization interface 3.5A [polypeptide binding]; other site 869216004506 active site 869216004507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869216004508 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 869216004509 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 869216004510 PhnA protein; Region: PhnA; pfam03831 869216004511 cytidylate kinase; Provisional; Region: cmk; PRK00023 869216004512 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 869216004513 CMP-binding site; other site 869216004514 The sites determining sugar specificity; other site 869216004515 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 869216004516 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 869216004517 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 869216004518 Ligand binding site; other site 869216004519 Putative Catalytic site; other site 869216004520 DXD motif; other site 869216004521 UDP-glucose 4-epimerase; Region: PLN02240 869216004522 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 869216004523 NAD binding site [chemical binding]; other site 869216004524 homodimer interface [polypeptide binding]; other site 869216004525 active site 869216004526 substrate binding site [chemical binding]; other site 869216004527 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 869216004528 Uncharacterized conserved protein [Function unknown]; Region: COG0327 869216004529 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 869216004530 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 869216004531 Family of unknown function (DUF633); Region: DUF633; pfam04816 869216004532 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 869216004533 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 869216004534 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 869216004535 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 869216004536 active site 869216004537 zinc binding site [ion binding]; other site 869216004538 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 869216004539 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 869216004540 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869216004541 ATP binding site [chemical binding]; other site 869216004542 putative Mg++ binding site [ion binding]; other site 869216004543 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869216004544 nucleotide binding region [chemical binding]; other site 869216004545 ATP-binding site [chemical binding]; other site 869216004546 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 869216004547 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869216004548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216004549 motif II; other site 869216004550 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 869216004551 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 869216004552 putative acyl-acceptor binding pocket; other site 869216004553 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 869216004554 Cadmium resistance transporter; Region: Cad; pfam03596 869216004555 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 869216004556 16S/18S rRNA binding site [nucleotide binding]; other site 869216004557 S13e-L30e interaction site [polypeptide binding]; other site 869216004558 25S rRNA binding site [nucleotide binding]; other site 869216004559 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 869216004560 NADH(P)-binding; Region: NAD_binding_10; pfam13460 869216004561 NAD binding site [chemical binding]; other site 869216004562 substrate binding site [chemical binding]; other site 869216004563 putative active site [active] 869216004564 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 869216004565 metal binding site [ion binding]; metal-binding site 869216004566 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 869216004567 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 869216004568 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 869216004569 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 869216004570 active site 869216004571 dimer interface [polypeptide binding]; other site 869216004572 motif 1; other site 869216004573 motif 2; other site 869216004574 motif 3; other site 869216004575 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 869216004576 anticodon binding site; other site 869216004577 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869216004578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869216004579 ATP binding site [chemical binding]; other site 869216004580 Mg2+ binding site [ion binding]; other site 869216004581 G-X-G motif; other site 869216004582 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869216004583 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869216004584 active site 869216004585 phosphorylation site [posttranslational modification] 869216004586 intermolecular recognition site; other site 869216004587 dimerization interface [polypeptide binding]; other site 869216004588 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869216004589 DNA binding site [nucleotide binding] 869216004590 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 869216004591 nucleophilic elbow; other site 869216004592 catalytic triad; other site 869216004593 Predicted transcriptional regulator [Transcription]; Region: COG1959 869216004594 Transcriptional regulator; Region: Rrf2; pfam02082 869216004595 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 869216004596 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869216004597 active site 869216004598 metal binding site [ion binding]; metal-binding site 869216004599 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 869216004600 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 869216004601 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 869216004602 FeoA domain; Region: FeoA; pfam04023 869216004603 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869216004604 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869216004605 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 869216004606 putative active site [active] 869216004607 dimerization interface [polypeptide binding]; other site 869216004608 putative tRNAtyr binding site [nucleotide binding]; other site 869216004609 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 869216004610 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869216004611 Zn2+ binding site [ion binding]; other site 869216004612 Mg2+ binding site [ion binding]; other site 869216004613 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869216004614 synthetase active site [active] 869216004615 NTP binding site [chemical binding]; other site 869216004616 metal binding site [ion binding]; metal-binding site 869216004617 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 869216004618 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 869216004619 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 869216004620 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 869216004621 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 869216004622 active site 869216004623 Zn binding site [ion binding]; other site 869216004624 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 869216004625 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 869216004626 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 869216004627 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869216004628 ABC-ATPase subunit interface; other site 869216004629 dimer interface [polypeptide binding]; other site 869216004630 putative PBP binding regions; other site 869216004631 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869216004632 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 869216004633 metal binding site [ion binding]; metal-binding site 869216004634 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 869216004635 dimer interface [polypeptide binding]; other site 869216004636 catalytic triad [active] 869216004637 peroxidatic and resolving cysteines [active] 869216004638 FtsX-like permease family; Region: FtsX; pfam02687 869216004639 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869216004640 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869216004641 FtsX-like permease family; Region: FtsX; pfam02687 869216004642 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869216004643 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869216004644 Walker A/P-loop; other site 869216004645 ATP binding site [chemical binding]; other site 869216004646 Q-loop/lid; other site 869216004647 ABC transporter signature motif; other site 869216004648 Walker B; other site 869216004649 D-loop; other site 869216004650 H-loop/switch region; other site 869216004651 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869216004652 catalytic core [active] 869216004653 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869216004654 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 869216004655 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869216004656 active site 869216004657 HIGH motif; other site 869216004658 nucleotide binding site [chemical binding]; other site 869216004659 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 869216004660 active site 869216004661 KMSKS motif; other site 869216004662 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 869216004663 tRNA binding surface [nucleotide binding]; other site 869216004664 anticodon binding site; other site 869216004665 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 869216004666 DivIVA domain; Region: DivI1A_domain; TIGR03544 869216004667 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 869216004668 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 869216004669 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 869216004670 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869216004671 RNA binding surface [nucleotide binding]; other site 869216004672 YGGT family; Region: YGGT; pfam02325 869216004673 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 869216004674 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 869216004675 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869216004676 catalytic residue [active] 869216004677 cell division protein FtsZ; Validated; Region: PRK09330 869216004678 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 869216004679 nucleotide binding site [chemical binding]; other site 869216004680 SulA interaction site; other site 869216004681 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 869216004682 Cell division protein FtsA; Region: FtsA; smart00842 869216004683 Cell division protein FtsA; Region: FtsA; pfam14450 869216004684 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 869216004685 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 869216004686 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 869216004687 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 869216004688 nudix motif; other site 869216004689 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 869216004690 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869216004691 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869216004692 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869216004693 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 869216004694 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 869216004695 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 869216004696 recombination protein RecR; Reviewed; Region: recR; PRK00076 869216004697 RecR protein; Region: RecR; pfam02132 869216004698 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 869216004699 putative active site [active] 869216004700 putative metal-binding site [ion binding]; other site 869216004701 tetramer interface [polypeptide binding]; other site 869216004702 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 869216004703 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869216004704 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869216004705 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869216004706 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 869216004707 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 869216004708 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 869216004709 putative active site [active] 869216004710 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869216004711 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869216004712 nucleotide binding site [chemical binding]; other site 869216004713 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 869216004714 Class I aldolases; Region: Aldolase_Class_I; cl17187 869216004715 catalytic residue [active] 869216004716 Protein of unknown function, DUF624; Region: DUF624; pfam04854 869216004717 Domain of unknown function (DUF386); Region: DUF386; pfam04074 869216004718 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869216004719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216004720 dimer interface [polypeptide binding]; other site 869216004721 conserved gate region; other site 869216004722 putative PBP binding loops; other site 869216004723 ABC-ATPase subunit interface; other site 869216004724 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869216004725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869216004726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216004727 putative PBP binding loops; other site 869216004728 dimer interface [polypeptide binding]; other site 869216004729 ABC-ATPase subunit interface; other site 869216004730 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869216004731 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869216004732 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 869216004733 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869216004734 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869216004735 active site turn [active] 869216004736 phosphorylation site [posttranslational modification] 869216004737 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 869216004738 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 869216004739 putative active site cavity [active] 869216004740 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869216004741 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869216004742 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869216004743 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 869216004744 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 869216004745 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869216004746 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869216004747 Asp-box motif; other site 869216004748 catalytic site [active] 869216004749 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869216004750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216004751 dimer interface [polypeptide binding]; other site 869216004752 conserved gate region; other site 869216004753 putative PBP binding loops; other site 869216004754 ABC-ATPase subunit interface; other site 869216004755 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869216004756 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216004757 dimer interface [polypeptide binding]; other site 869216004758 conserved gate region; other site 869216004759 putative PBP binding loops; other site 869216004760 ABC-ATPase subunit interface; other site 869216004761 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869216004762 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869216004763 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 869216004764 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869216004765 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 869216004766 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869216004767 catalytic site [active] 869216004768 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869216004769 Asp-box motif; other site 869216004770 Asp-box motif; other site 869216004771 catalytic site [active] 869216004772 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 869216004773 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 869216004774 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 869216004775 ssDNA binding site; other site 869216004776 generic binding surface II; other site 869216004777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869216004778 ATP binding site [chemical binding]; other site 869216004779 putative Mg++ binding site [ion binding]; other site 869216004780 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869216004781 nucleotide binding region [chemical binding]; other site 869216004782 ATP-binding site [chemical binding]; other site 869216004783 alanine racemase; Reviewed; Region: alr; PRK00053 869216004784 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 869216004785 active site 869216004786 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869216004787 dimer interface [polypeptide binding]; other site 869216004788 substrate binding site [chemical binding]; other site 869216004789 catalytic residues [active] 869216004790 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 869216004791 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 869216004792 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 869216004793 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 869216004794 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 869216004795 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 869216004796 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 869216004797 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869216004798 nucleotide binding region [chemical binding]; other site 869216004799 ATP-binding site [chemical binding]; other site 869216004800 SEC-C motif; Region: SEC-C; pfam02810 869216004801 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 869216004802 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869216004803 Walker A/P-loop; other site 869216004804 ATP binding site [chemical binding]; other site 869216004805 Q-loop/lid; other site 869216004806 ABC transporter signature motif; other site 869216004807 Walker B; other site 869216004808 D-loop; other site 869216004809 H-loop/switch region; other site 869216004810 GTP-binding protein Der; Reviewed; Region: PRK00093 869216004811 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 869216004812 G1 box; other site 869216004813 GTP/Mg2+ binding site [chemical binding]; other site 869216004814 Switch I region; other site 869216004815 G2 box; other site 869216004816 Switch II region; other site 869216004817 G3 box; other site 869216004818 G4 box; other site 869216004819 G5 box; other site 869216004820 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 869216004821 G1 box; other site 869216004822 GTP/Mg2+ binding site [chemical binding]; other site 869216004823 Switch I region; other site 869216004824 G2 box; other site 869216004825 G3 box; other site 869216004826 Switch II region; other site 869216004827 G4 box; other site 869216004828 G5 box; other site 869216004829 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 869216004830 dimer interface [polypeptide binding]; other site 869216004831 FMN binding site [chemical binding]; other site 869216004832 NADPH bind site [chemical binding]; other site 869216004833 primosomal protein DnaI; Reviewed; Region: PRK08939 869216004834 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 869216004835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216004836 Walker A motif; other site 869216004837 ATP binding site [chemical binding]; other site 869216004838 Walker B motif; other site 869216004839 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 869216004840 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 869216004841 ATP cone domain; Region: ATP-cone; pfam03477 869216004842 Predicted transcriptional regulators [Transcription]; Region: COG1725 869216004843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869216004844 DNA-binding site [nucleotide binding]; DNA binding site 869216004845 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 869216004846 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869216004847 Walker A/P-loop; other site 869216004848 ATP binding site [chemical binding]; other site 869216004849 Q-loop/lid; other site 869216004850 ABC transporter signature motif; other site 869216004851 Walker B; other site 869216004852 D-loop; other site 869216004853 H-loop/switch region; other site 869216004854 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 869216004855 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 869216004856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216004857 Walker A/P-loop; other site 869216004858 ATP binding site [chemical binding]; other site 869216004859 Q-loop/lid; other site 869216004860 ABC transporter signature motif; other site 869216004861 Walker B; other site 869216004862 D-loop; other site 869216004863 H-loop/switch region; other site 869216004864 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 869216004866 Uncharacterized conserved protein [Function unknown]; Region: COG0398 869216004867 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 869216004868 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869216004869 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869216004870 nucleotide binding site [chemical binding]; other site 869216004871 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 869216004872 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869216004873 active site turn [active] 869216004874 phosphorylation site [posttranslational modification] 869216004875 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869216004876 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 869216004877 HPr interaction site; other site 869216004878 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869216004879 active site 869216004880 phosphorylation site [posttranslational modification] 869216004881 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 869216004882 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 869216004883 substrate binding [chemical binding]; other site 869216004884 active site 869216004885 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 869216004886 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869216004887 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869216004888 DNA binding site [nucleotide binding] 869216004889 domain linker motif; other site 869216004890 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 869216004891 dimerization interface [polypeptide binding]; other site 869216004892 ligand binding site [chemical binding]; other site 869216004893 sodium binding site [ion binding]; other site 869216004894 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 869216004895 homodimer interface [polypeptide binding]; other site 869216004896 catalytic residues [active] 869216004897 NAD binding site [chemical binding]; other site 869216004898 substrate binding pocket [chemical binding]; other site 869216004899 flexible flap; other site 869216004900 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 869216004901 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 869216004902 dimer interface [polypeptide binding]; other site 869216004903 active site 869216004904 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 869216004905 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 869216004906 Uncharacterized conserved protein [Function unknown]; Region: COG3610 869216004907 Uncharacterized conserved protein [Function unknown]; Region: COG2966 869216004908 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 869216004909 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 869216004910 Catalytic domain of Protein Kinases; Region: PKc; cd00180 869216004911 active site 869216004912 ATP binding site [chemical binding]; other site 869216004913 substrate binding site [chemical binding]; other site 869216004914 activation loop (A-loop); other site 869216004915 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 869216004916 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 869216004917 PASTA domain; Region: PASTA; smart00740 869216004918 PASTA domain; Region: PASTA; smart00740 869216004919 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 869216004920 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 869216004921 active site 869216004922 16S rRNA methyltransferase B; Provisional; Region: PRK14902 869216004923 NusB family; Region: NusB; pfam01029 869216004924 putative RNA binding site [nucleotide binding]; other site 869216004925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216004926 S-adenosylmethionine binding site [chemical binding]; other site 869216004927 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 869216004928 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 869216004929 putative active site [active] 869216004930 substrate binding site [chemical binding]; other site 869216004931 putative cosubstrate binding site; other site 869216004932 catalytic site [active] 869216004933 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 869216004934 substrate binding site [chemical binding]; other site 869216004935 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 869216004936 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869216004937 ATP binding site [chemical binding]; other site 869216004938 putative Mg++ binding site [ion binding]; other site 869216004939 helicase superfamily c-terminal domain; Region: HELICc; smart00490 869216004940 ATP-binding site [chemical binding]; other site 869216004941 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 869216004942 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 869216004943 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 869216004944 catalytic site [active] 869216004945 G-X2-G-X-G-K; other site 869216004946 hypothetical protein; Provisional; Region: PRK00106 869216004947 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869216004948 Zn2+ binding site [ion binding]; other site 869216004949 Mg2+ binding site [ion binding]; other site 869216004951 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 869216004952 hypothetical protein; Provisional; Region: PRK13670 869216004953 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 869216004954 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 869216004955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216004956 S-adenosylmethionine binding site [chemical binding]; other site 869216004957 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 869216004958 Isochorismatase family; Region: Isochorismatase; pfam00857 869216004959 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 869216004960 catalytic triad [active] 869216004961 conserved cis-peptide bond; other site 869216004962 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869216004963 Zn2+ binding site [ion binding]; other site 869216004964 Mg2+ binding site [ion binding]; other site 869216004965 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 869216004966 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 869216004967 active site 869216004968 (T/H)XGH motif; other site 869216004969 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 869216004970 GTPase YqeH; Provisional; Region: PRK13796 869216004971 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 869216004972 GTP/Mg2+ binding site [chemical binding]; other site 869216004973 G4 box; other site 869216004974 G5 box; other site 869216004975 G1 box; other site 869216004976 Switch I region; other site 869216004977 G2 box; other site 869216004978 G3 box; other site 869216004979 Switch II region; other site 869216004980 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 869216004981 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216004982 active site 869216004983 motif I; other site 869216004984 motif II; other site 869216004985 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 869216004986 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 869216004987 Cl binding site [ion binding]; other site 869216004988 oligomer interface [polypeptide binding]; other site 869216004989 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 869216004990 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869216004991 serine/threonine transporter SstT; Provisional; Region: PRK14695 869216004992 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 869216004993 Predicted membrane protein [Function unknown]; Region: COG4129 869216004994 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 869216004995 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 869216004996 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 869216004997 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869216004998 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 869216004999 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 869216005000 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 869216005001 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 869216005002 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 869216005003 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 869216005004 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 869216005005 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 869216005006 SecY translocase; Region: SecY; pfam00344 869216005007 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 869216005008 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869216005009 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 869216005010 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 869216005011 Ligand binding site; other site 869216005012 metal-binding site 869216005013 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 869216005014 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 869216005015 Ligand binding site; other site 869216005016 metal-binding site 869216005017 glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728 869216005018 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 869216005019 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 869216005020 Ligand binding site; other site 869216005021 metal-binding site 869216005023 serine-rich repeat adhesion glycoprotein AST domain; Region: ser_adhes_Nterm; TIGR04224 869216005024 match to Transposase_14 (PF01710) 869216005025 MarR family; Region: MarR; pfam01047 869216005026 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869216005027 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869216005028 catalytic residues [active] 869216005029 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 869216005030 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 869216005031 amphipathic channel; other site 869216005032 Asn-Pro-Ala signature motifs; other site 869216005033 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 869216005034 oligoendopeptidase F; Region: pepF; TIGR00181 869216005035 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 869216005036 Zn binding site [ion binding]; other site 869216005037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 869216005038 RNA methyltransferase, RsmE family; Region: TIGR00046 869216005039 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 869216005040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216005041 S-adenosylmethionine binding site [chemical binding]; other site 869216005042 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 869216005043 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 869216005044 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 869216005045 active site 869216005046 catalytic triad [active] 869216005047 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869216005048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216005049 Walker A motif; other site 869216005050 ATP binding site [chemical binding]; other site 869216005051 Walker B motif; other site 869216005052 arginine finger; other site 869216005053 Peptidase family M50; Region: Peptidase_M50; pfam02163 869216005054 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 869216005055 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 869216005056 recombination factor protein RarA; Reviewed; Region: PRK13342 869216005057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216005058 Walker A motif; other site 869216005059 ATP binding site [chemical binding]; other site 869216005060 Walker B motif; other site 869216005061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 869216005062 arginine finger; other site 869216005063 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 869216005064 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 869216005065 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 869216005066 substrate binding [chemical binding]; other site 869216005067 active site 869216005068 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 869216005069 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869216005070 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869216005071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216005072 dimer interface [polypeptide binding]; other site 869216005073 conserved gate region; other site 869216005074 ABC-ATPase subunit interface; other site 869216005075 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869216005076 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216005077 dimer interface [polypeptide binding]; other site 869216005078 conserved gate region; other site 869216005079 ABC-ATPase subunit interface; other site 869216005080 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869216005081 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869216005082 DNA binding site [nucleotide binding] 869216005083 domain linker motif; other site 869216005084 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 869216005085 dimerization interface [polypeptide binding]; other site 869216005086 ligand binding site [chemical binding]; other site 869216005087 sodium binding site [ion binding]; other site 869216005088 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 869216005089 Mga helix-turn-helix domain; Region: Mga; pfam05043 869216005090 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 869216005091 Predicted membrane protein [Function unknown]; Region: COG2261 869216005092 Small integral membrane protein [Function unknown]; Region: COG5547 869216005093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 869216005095 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 869216005096 Uncharacterized conserved protein [Function unknown]; Region: COG1262 869216005097 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 869216005098 arylsulfatase; Provisional; Region: PRK13759 869216005099 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 869216005100 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869216005101 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 869216005102 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869216005103 active site 869216005104 methionine cluster; other site 869216005105 phosphorylation site [posttranslational modification] 869216005106 metal binding site [ion binding]; metal-binding site 869216005107 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 869216005108 active site 869216005109 P-loop; other site 869216005110 phosphorylation site [posttranslational modification] 869216005111 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 869216005112 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869216005113 MarR family; Region: MarR_2; pfam12802 869216005114 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869216005115 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869216005116 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869216005117 Coenzyme A binding pocket [chemical binding]; other site 869216005118 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 869216005119 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 869216005120 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 869216005121 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869216005122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216005123 non-specific DNA binding site [nucleotide binding]; other site 869216005124 salt bridge; other site 869216005125 sequence-specific DNA binding site [nucleotide binding]; other site 869216005126 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 869216005128 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 869216005129 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 869216005130 substrate binding site [chemical binding]; other site 869216005131 active site 869216005132 catalytic residues [active] 869216005133 heterodimer interface [polypeptide binding]; other site 869216005134 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 869216005135 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 869216005136 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869216005137 catalytic residue [active] 869216005138 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 869216005139 active site 869216005140 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 869216005141 active site 869216005142 ribulose/triose binding site [chemical binding]; other site 869216005143 phosphate binding site [ion binding]; other site 869216005144 substrate (anthranilate) binding pocket [chemical binding]; other site 869216005145 product (indole) binding pocket [chemical binding]; other site 869216005146 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 869216005147 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869216005148 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869216005149 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 869216005150 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 869216005151 glutamine binding [chemical binding]; other site 869216005152 catalytic triad [active] 869216005153 anthranilate synthase component I; Provisional; Region: PRK13570 869216005154 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 869216005155 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 869216005156 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 869216005157 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869216005158 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869216005159 DNA binding site [nucleotide binding] 869216005160 domain linker motif; other site 869216005161 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 869216005162 putative dimerization interface [polypeptide binding]; other site 869216005163 putative ligand binding site [chemical binding]; other site 869216005164 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 869216005165 MgtC family; Region: MgtC; pfam02308 869216005166 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 869216005167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216005168 dimer interface [polypeptide binding]; other site 869216005169 conserved gate region; other site 869216005170 putative PBP binding loops; other site 869216005171 ABC-ATPase subunit interface; other site 869216005172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216005173 putative PBP binding loops; other site 869216005174 dimer interface [polypeptide binding]; other site 869216005175 ABC-ATPase subunit interface; other site 869216005176 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869216005177 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216005178 Walker A/P-loop; other site 869216005179 ATP binding site [chemical binding]; other site 869216005180 Q-loop/lid; other site 869216005181 ABC transporter signature motif; other site 869216005182 Walker B; other site 869216005183 D-loop; other site 869216005184 H-loop/switch region; other site 869216005185 TOBE domain; Region: TOBE; pfam03459 869216005186 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 869216005187 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869216005188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 869216005189 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 869216005191 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869216005192 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 869216005193 Pectate lyase; Region: Pec_lyase_C; cl01593 869216005194 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 869216005195 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 869216005196 inhibitor-cofactor binding pocket; inhibition site 869216005197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869216005198 catalytic residue [active] 869216005199 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 869216005200 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869216005201 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869216005202 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 869216005203 Walker A/P-loop; other site 869216005204 ATP binding site [chemical binding]; other site 869216005205 Q-loop/lid; other site 869216005206 ABC transporter signature motif; other site 869216005207 Walker B; other site 869216005208 D-loop; other site 869216005209 H-loop/switch region; other site 869216005210 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869216005211 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 869216005212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216005213 Walker A/P-loop; other site 869216005214 ATP binding site [chemical binding]; other site 869216005215 Q-loop/lid; other site 869216005216 ABC transporter signature motif; other site 869216005217 Walker B; other site 869216005218 D-loop; other site 869216005219 H-loop/switch region; other site 869216005220 Predicted membrane protein [Function unknown]; Region: COG2323 869216005221 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 869216005222 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 869216005223 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 869216005224 active site 869216005225 putative catalytic site [active] 869216005226 DNA binding site [nucleotide binding] 869216005227 putative phosphate binding site [ion binding]; other site 869216005228 metal binding site A [ion binding]; metal-binding site 869216005229 AP binding site [nucleotide binding]; other site 869216005230 metal binding site B [ion binding]; metal-binding site 869216005231 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869216005232 active site 869216005233 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869216005234 active site 869216005235 xanthine permease; Region: pbuX; TIGR03173 869216005236 Sulfate transporter family; Region: Sulfate_transp; pfam00916 869216005237 DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207 869216005238 Dam-replacing family; Region: DRP; pfam06044 869216005239 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 869216005240 CoenzymeA binding site [chemical binding]; other site 869216005241 subunit interaction site [polypeptide binding]; other site 869216005242 PHB binding site; other site 869216005243 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 869216005244 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 869216005245 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 869216005246 galactokinase; Provisional; Region: PRK05322 869216005247 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 869216005248 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869216005249 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869216005250 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 869216005251 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869216005252 DNA binding site [nucleotide binding] 869216005253 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 869216005254 putative dimerization interface [polypeptide binding]; other site 869216005255 putative ligand binding site [chemical binding]; other site 869216005256 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 869216005257 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869216005258 catalytic Zn binding site [ion binding]; other site 869216005259 NAD(P) binding site [chemical binding]; other site 869216005260 structural Zn binding site [ion binding]; other site 869216005261 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 869216005262 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 869216005263 DNA binding residues [nucleotide binding] 869216005264 putative dimer interface [polypeptide binding]; other site 869216005265 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 869216005266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869216005267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869216005268 Utp21 specific WD40 associated putative domain; Region: Utp21; pfam04192 869216005269 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 869216005270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216005271 dimer interface [polypeptide binding]; other site 869216005272 conserved gate region; other site 869216005273 ABC-ATPase subunit interface; other site 869216005274 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 869216005275 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 869216005276 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869216005277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216005278 Walker A/P-loop; other site 869216005279 ATP binding site [chemical binding]; other site 869216005280 Q-loop/lid; other site 869216005281 ABC transporter signature motif; other site 869216005282 Walker B; other site 869216005283 D-loop; other site 869216005284 H-loop/switch region; other site 869216005285 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 869216005286 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 869216005287 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869216005288 Enterocin A Immunity; Region: EntA_Immun; pfam08951 869216005289 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 869216005290 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 869216005291 oligomer interface [polypeptide binding]; other site 869216005292 active site 869216005293 metal binding site [ion binding]; metal-binding site 869216005294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869216005295 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 869216005296 NAD(P) binding site [chemical binding]; other site 869216005297 active site 869216005298 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869216005299 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869216005300 ABC-ATPase subunit interface; other site 869216005301 dimer interface [polypeptide binding]; other site 869216005302 putative PBP binding regions; other site 869216005303 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869216005304 ABC-ATPase subunit interface; other site 869216005305 dimer interface [polypeptide binding]; other site 869216005306 putative PBP binding regions; other site 869216005307 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 869216005308 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869216005309 Walker A/P-loop; other site 869216005310 ATP binding site [chemical binding]; other site 869216005311 Q-loop/lid; other site 869216005312 ABC transporter signature motif; other site 869216005313 Walker B; other site 869216005314 D-loop; other site 869216005315 H-loop/switch region; other site 869216005316 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 869216005317 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 869216005318 putative ligand binding residues [chemical binding]; other site 869216005319 hypothetical protein; Validated; Region: PRK00041 869216005320 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869216005321 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869216005322 RNA binding surface [nucleotide binding]; other site 869216005323 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 869216005324 active site 869216005325 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 869216005326 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 869216005327 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 869216005328 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 869216005329 DNA binding site [nucleotide binding] 869216005330 Int/Topo IB signature motif; other site 869216005331 active site 869216005332 catalytic residues [active] 869216005333 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 869216005334 FOG: CBS domain [General function prediction only]; Region: COG0517 869216005335 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 869216005336 active site 869216005337 metal binding site [ion binding]; metal-binding site 869216005338 homotetramer interface [polypeptide binding]; other site 869216005339 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 869216005340 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 869216005341 active site 869216005342 dimerization interface [polypeptide binding]; other site 869216005343 glutamate racemase; Provisional; Region: PRK00865 869216005344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 869216005345 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 869216005346 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 869216005347 Ca binding site [ion binding]; other site 869216005348 active site 869216005349 catalytic site [active] 869216005350 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 869216005351 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869216005352 active site turn [active] 869216005353 phosphorylation site [posttranslational modification] 869216005354 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869216005355 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 869216005356 HPr interaction site; other site 869216005357 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869216005358 active site 869216005359 phosphorylation site [posttranslational modification] 869216005360 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869216005361 DNA-binding site [nucleotide binding]; DNA binding site 869216005362 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 869216005363 UTRA domain; Region: UTRA; pfam07702 869216005364 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 869216005365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869216005366 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869216005367 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 869216005368 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869216005369 Walker A/P-loop; other site 869216005370 ATP binding site [chemical binding]; other site 869216005371 Q-loop/lid; other site 869216005372 ABC transporter signature motif; other site 869216005373 Walker B; other site 869216005374 D-loop; other site 869216005375 H-loop/switch region; other site 869216005376 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 869216005377 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 869216005378 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869216005379 Walker A/P-loop; other site 869216005380 ATP binding site [chemical binding]; other site 869216005381 Q-loop/lid; other site 869216005382 ABC transporter signature motif; other site 869216005383 Walker B; other site 869216005384 D-loop; other site 869216005385 H-loop/switch region; other site 869216005386 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869216005387 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 869216005388 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 869216005389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216005390 dimer interface [polypeptide binding]; other site 869216005391 conserved gate region; other site 869216005392 putative PBP binding loops; other site 869216005393 ABC-ATPase subunit interface; other site 869216005394 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869216005395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216005396 dimer interface [polypeptide binding]; other site 869216005397 conserved gate region; other site 869216005398 putative PBP binding loops; other site 869216005399 ABC-ATPase subunit interface; other site 869216005400 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869216005401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216005402 dimer interface [polypeptide binding]; other site 869216005403 conserved gate region; other site 869216005404 putative PBP binding loops; other site 869216005405 ABC-ATPase subunit interface; other site 869216005406 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869216005407 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869216005408 peptide binding site [polypeptide binding]; other site 869216005409 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 869216005410 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 869216005411 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 869216005412 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 869216005413 active site 869216005414 homodimer interface [polypeptide binding]; other site 869216005415 catalytic site [active] 869216005416 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869216005417 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216005418 dimer interface [polypeptide binding]; other site 869216005419 conserved gate region; other site 869216005420 putative PBP binding loops; other site 869216005421 ABC-ATPase subunit interface; other site 869216005422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216005423 dimer interface [polypeptide binding]; other site 869216005424 conserved gate region; other site 869216005425 putative PBP binding loops; other site 869216005426 ABC-ATPase subunit interface; other site 869216005427 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869216005428 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869216005429 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 869216005430 Melibiase; Region: Melibiase; pfam02065 869216005431 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 869216005432 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869216005433 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869216005434 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869216005435 Biotin operon repressor [Transcription]; Region: BirA; COG1654 869216005436 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 869216005437 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 869216005438 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 869216005439 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 869216005440 TRAM domain; Region: TRAM; cl01282 869216005441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216005442 S-adenosylmethionine binding site [chemical binding]; other site 869216005443 recombination regulator RecX; Provisional; Region: recX; PRK14135 869216005444 hypothetical protein; Provisional; Region: PRK13662 869216005445 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869216005447 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 869216005448 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 869216005449 ring oligomerisation interface [polypeptide binding]; other site 869216005450 ATP/Mg binding site [chemical binding]; other site 869216005451 stacking interactions; other site 869216005452 hinge regions; other site 869216005453 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 869216005454 oligomerisation interface [polypeptide binding]; other site 869216005455 mobile loop; other site 869216005456 roof hairpin; other site 869216005457 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869216005458 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869216005459 dimer interface [polypeptide binding]; other site 869216005460 ssDNA binding site [nucleotide binding]; other site 869216005461 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869216005462 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 869216005463 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 869216005464 putative NAD(P) binding site [chemical binding]; other site 869216005465 homodimer interface [polypeptide binding]; other site 869216005466 homotetramer interface [polypeptide binding]; other site 869216005467 active site 869216005468 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 869216005469 putative tRNA-binding site [nucleotide binding]; other site 869216005470 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869216005471 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869216005472 catalytic residues [active] 869216005473 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869216005474 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 869216005475 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869216005476 LytTr DNA-binding domain; Region: LytTR; pfam04397 869216005477 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869216005478 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 869216005479 active site 869216005480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4898 869216005481 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869216005482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216005483 Walker A/P-loop; other site 869216005484 ATP binding site [chemical binding]; other site 869216005485 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 869216005486 Walker A/P-loop; other site 869216005487 ATP binding site [chemical binding]; other site 869216005488 Q-loop/lid; other site 869216005489 ABC transporter signature motif; other site 869216005490 Walker B; other site 869216005491 D-loop; other site 869216005492 H-loop/switch region; other site 869216005494 hypothetical protein; Provisional; Region: PRK12378 869216005495 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 869216005496 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 869216005499 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 869216005500 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869216005501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216005502 non-specific DNA binding site [nucleotide binding]; other site 869216005503 salt bridge; other site 869216005504 sequence-specific DNA binding site [nucleotide binding]; other site 869216005505 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869216005506 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 869216005507 amidase catalytic site [active] 869216005508 Zn binding residues [ion binding]; other site 869216005509 substrate binding site [chemical binding]; other site 869216005510 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216005511 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216005512 Appears to be truncated 869216005513 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 869216005514 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 869216005515 recombinase A; Provisional; Region: recA; PRK09354 869216005516 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 869216005517 hexamer interface [polypeptide binding]; other site 869216005518 Walker A motif; other site 869216005519 ATP binding site [chemical binding]; other site 869216005520 Walker B motif; other site 869216005521 competence damage-inducible protein A; Provisional; Region: PRK00549 869216005522 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 869216005523 putative MPT binding site; other site 869216005524 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 869216005525 Transcriptional regulator [Transcription]; Region: LytR; COG1316 869216005526 putative acetyltransferase YhhY; Provisional; Region: PRK10140 869216005527 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869216005528 Coenzyme A binding pocket [chemical binding]; other site 869216005529 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 869216005530 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869216005531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216005532 non-specific DNA binding site [nucleotide binding]; other site 869216005533 salt bridge; other site 869216005534 sequence-specific DNA binding site [nucleotide binding]; other site 869216005535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 869216005536 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 869216005537 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869216005538 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869216005539 Walker A/P-loop; other site 869216005540 ATP binding site [chemical binding]; other site 869216005541 Q-loop/lid; other site 869216005542 ABC transporter signature motif; other site 869216005543 Walker B; other site 869216005544 D-loop; other site 869216005545 H-loop/switch region; other site 869216005546 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 869216005547 active site 869216005548 multimer interface [polypeptide binding]; other site 869216005549 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 869216005550 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 869216005551 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 869216005552 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 869216005553 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 869216005554 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 869216005555 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 869216005556 G-loop; other site 869216005557 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 869216005558 DNA binding site [nucleotide binding] 869216005559 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 869216005560 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 869216005561 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 869216005562 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 869216005563 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 869216005564 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 869216005565 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 869216005566 RPB1 interaction site [polypeptide binding]; other site 869216005567 RPB10 interaction site [polypeptide binding]; other site 869216005568 RPB11 interaction site [polypeptide binding]; other site 869216005569 RPB3 interaction site [polypeptide binding]; other site 869216005570 RPB12 interaction site [polypeptide binding]; other site 869216005571 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 869216005572 Domain of unknown function DUF21; Region: DUF21; pfam01595 869216005573 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 869216005574 Transporter associated domain; Region: CorC_HlyC; smart01091 869216005575 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 869216005576 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 869216005577 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 869216005578 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 869216005579 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 869216005580 hinge; other site 869216005581 active site 869216005582 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 869216005583 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 869216005584 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 869216005585 protein binding site [polypeptide binding]; other site 869216005586 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 869216005587 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 869216005588 active site 869216005589 (T/H)XGH motif; other site 869216005590 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 869216005591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216005592 S-adenosylmethionine binding site [chemical binding]; other site 869216005593 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 869216005594 dimer interface [polypeptide binding]; other site 869216005595 active site 869216005596 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 869216005597 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 869216005598 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 869216005599 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 869216005600 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869216005601 acylphosphatase; Provisional; Region: PRK14434 869216005602 OxaA-like protein precursor; Provisional; Region: PRK02463 869216005603 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 869216005604 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 869216005605 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869216005606 FeS/SAM binding site; other site 869216005607 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 869216005608 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 869216005609 active site 869216005610 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869216005611 substrate binding site [chemical binding]; other site 869216005612 catalytic residues [active] 869216005613 dimer interface [polypeptide binding]; other site 869216005614 pur operon repressor; Provisional; Region: PRK09213 869216005615 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 869216005616 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869216005617 active site 869216005618 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 869216005619 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 869216005620 generic binding surface II; other site 869216005621 generic binding surface I; other site 869216005622 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869216005623 Zn2+ binding site [ion binding]; other site 869216005624 Mg2+ binding site [ion binding]; other site 869216005625 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 869216005626 RmuC family; Region: RmuC; pfam02646 869216005627 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 869216005628 Thiamine pyrophosphokinase; Region: TPK; cd07995 869216005629 active site 869216005630 dimerization interface [polypeptide binding]; other site 869216005631 thiamine binding site [chemical binding]; other site 869216005632 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 869216005633 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 869216005634 substrate binding site [chemical binding]; other site 869216005635 hexamer interface [polypeptide binding]; other site 869216005636 metal binding site [ion binding]; metal-binding site 869216005637 GTPase RsgA; Reviewed; Region: PRK00098 869216005638 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 869216005639 RNA binding site [nucleotide binding]; other site 869216005640 homodimer interface [polypeptide binding]; other site 869216005641 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 869216005642 GTPase/Zn-binding domain interface [polypeptide binding]; other site 869216005643 GTP/Mg2+ binding site [chemical binding]; other site 869216005644 G4 box; other site 869216005645 G5 box; other site 869216005646 G1 box; other site 869216005647 Switch I region; other site 869216005648 G2 box; other site 869216005649 G3 box; other site 869216005650 Switch II region; other site 869216005651 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 869216005652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216005653 S-adenosylmethionine binding site [chemical binding]; other site 869216005654 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869216005655 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869216005656 Walker A/P-loop; other site 869216005657 ATP binding site [chemical binding]; other site 869216005658 Q-loop/lid; other site 869216005659 ABC transporter signature motif; other site 869216005660 Walker B; other site 869216005661 D-loop; other site 869216005662 H-loop/switch region; other site 869216005663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 869216005664 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 869216005665 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 869216005666 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869216005667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216005668 non-specific DNA binding site [nucleotide binding]; other site 869216005669 salt bridge; other site 869216005670 sequence-specific DNA binding site [nucleotide binding]; other site 869216005671 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 869216005672 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 869216005673 putative active site [active] 869216005674 putative metal binding site [ion binding]; other site 869216005675 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 869216005676 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 869216005677 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 869216005678 active site 869216005679 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869216005680 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 869216005681 aminotransferase AlaT; Validated; Region: PRK09265 869216005682 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869216005683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869216005684 homodimer interface [polypeptide binding]; other site 869216005685 catalytic residue [active] 869216005686 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 869216005687 Ligand Binding Site [chemical binding]; other site 869216005688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216005689 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869216005690 active site 869216005691 motif I; other site 869216005692 motif II; other site 869216005693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216005694 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 869216005695 putative nucleotide binding site [chemical binding]; other site 869216005696 putative metal binding site [ion binding]; other site 869216005697 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 869216005698 active site 869216005699 homotetramer interface [polypeptide binding]; other site 869216005700 homodimer interface [polypeptide binding]; other site 869216005701 catabolite control protein A; Region: ccpA; TIGR01481 869216005702 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869216005703 DNA binding site [nucleotide binding] 869216005704 domain linker motif; other site 869216005705 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 869216005706 dimerization interface [polypeptide binding]; other site 869216005707 effector binding site; other site 869216005708 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869216005709 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869216005710 active site 869216005711 phosphorylation site [posttranslational modification] 869216005712 intermolecular recognition site; other site 869216005713 dimerization interface [polypeptide binding]; other site 869216005714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869216005715 DNA binding residues [nucleotide binding] 869216005716 dimerization interface [polypeptide binding]; other site 869216005717 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 869216005718 Histidine kinase; Region: HisKA_3; pfam07730 869216005719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869216005720 ATP binding site [chemical binding]; other site 869216005721 Mg2+ binding site [ion binding]; other site 869216005722 G-X-G motif; other site 869216005723 ABC-2 type transporter; Region: ABC2_membrane; cl17235 869216005724 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 869216005725 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869216005726 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869216005727 Walker A/P-loop; other site 869216005728 ATP binding site [chemical binding]; other site 869216005729 Q-loop/lid; other site 869216005730 ABC transporter signature motif; other site 869216005731 Walker B; other site 869216005732 D-loop; other site 869216005733 H-loop/switch region; other site 869216005734 manually curated to include N-terminal signal sequence 869216005735 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 869216005736 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 869216005737 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 869216005738 putative homodimer interface [polypeptide binding]; other site 869216005739 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 869216005740 heterodimer interface [polypeptide binding]; other site 869216005741 homodimer interface [polypeptide binding]; other site 869216005742 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 869216005743 Helix-turn-helix domain; Region: HTH_28; pfam13518 869216005744 Winged helix-turn helix; Region: HTH_29; pfam13551 869216005745 Homeodomain-like domain; Region: HTH_32; pfam13565 869216005746 Integrase core domain; Region: rve; pfam00665 869216005747 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 869216005748 Transglycosylase; Region: Transgly; pfam00912 869216005749 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869216005750 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869216005751 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869216005752 active site 869216005753 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869216005754 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869216005755 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 869216005756 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 869216005757 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 869216005758 FtsX-like permease family; Region: FtsX; pfam02687 869216005760 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559 869216005761 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 869216005762 dimerization interface [polypeptide binding]; other site 869216005763 active site 869216005764 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 869216005765 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869216005766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 869216005767 Walker A/P-loop; other site 869216005768 ATP binding site [chemical binding]; other site 869216005769 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869216005770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869216005771 DNA-binding site [nucleotide binding]; DNA binding site 869216005772 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 869216005773 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 869216005774 beta-galactosidase; Region: BGL; TIGR03356 869216005775 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869216005776 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 869216005778 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869216005779 methionine cluster; other site 869216005780 active site 869216005781 phosphorylation site [posttranslational modification] 869216005782 metal binding site [ion binding]; metal-binding site 869216005783 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 869216005784 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 869216005785 putative catalytic cysteine [active] 869216005786 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 869216005787 putative active site [active] 869216005788 metal binding site [ion binding]; metal-binding site 869216005789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 869216005790 MORN repeat; Region: MORN; cl14787 869216005791 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 869216005792 Low molecular weight phosphatase family; Region: LMWPc; cd00115 869216005793 active site 869216005794 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 869216005795 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 869216005796 Low molecular weight phosphatase family; Region: LMWPc; cl00105 869216005797 active site 869216005798 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 869216005799 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 869216005800 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869216005801 TPP-binding site [chemical binding]; other site 869216005802 dimer interface [polypeptide binding]; other site 869216005803 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869216005804 PYR/PP interface [polypeptide binding]; other site 869216005805 dimer interface [polypeptide binding]; other site 869216005806 TPP binding site [chemical binding]; other site 869216005807 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869216005808 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 869216005809 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 869216005810 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869216005811 PRD domain; Region: PRD; pfam00874 869216005812 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869216005813 active site 869216005814 P-loop; other site 869216005815 phosphorylation site [posttranslational modification] 869216005816 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 869216005817 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 869216005818 intersubunit interface [polypeptide binding]; other site 869216005819 active site 869216005820 Zn2+ binding site [ion binding]; other site 869216005821 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 869216005822 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 869216005823 AP (apurinic/apyrimidinic) site pocket; other site 869216005824 DNA interaction; other site 869216005825 Metal-binding active site; metal-binding site 869216005826 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 869216005827 active site 869216005828 dimer interface [polypeptide binding]; other site 869216005829 magnesium binding site [ion binding]; other site 869216005830 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869216005831 active site 869216005832 phosphorylation site [posttranslational modification] 869216005833 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 869216005834 active site 869216005835 P-loop; other site 869216005836 phosphorylation site [posttranslational modification] 869216005837 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 869216005838 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 869216005839 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 869216005840 G-X-X-G motif; other site 869216005841 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 869216005842 RxxxH motif; other site 869216005843 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 869216005844 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 869216005845 ribonuclease P; Reviewed; Region: rnpA; PRK00499 869216005846 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 869216005847 propionate/acetate kinase; Provisional; Region: PRK12379 869216005848 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 869216005849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216005850 S-adenosylmethionine binding site [chemical binding]; other site 869216005852 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 869216005853 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 869216005854 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 869216005855 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 869216005856 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 869216005857 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 869216005858 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 869216005859 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869216005860 Walker A motif; other site 869216005861 ATP binding site [chemical binding]; other site 869216005862 Walker B motif; other site 869216005863 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 869216005864 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 869216005865 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869216005866 catalytic Zn binding site [ion binding]; other site 869216005867 structural Zn binding site [ion binding]; other site 869216005868 NAD(P) binding site [chemical binding]; other site 869216005869 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 869216005870 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 869216005871 active site 869216005872 dimer interface [polypeptide binding]; other site 869216005873 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 869216005874 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 869216005875 catalytic triad [active] 869216005876 catalytic triad [active] 869216005877 oxyanion hole [active] 869216005878 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 869216005879 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 869216005880 Predicted integral membrane protein [Function unknown]; Region: COG5523 869216005882 Predicted membrane protein [Function unknown]; Region: COG3759 869216005883 Transcriptional regulators [Transcription]; Region: MarR; COG1846 869216005884 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869216005885 putative DNA binding site [nucleotide binding]; other site 869216005886 putative Zn2+ binding site [ion binding]; other site 869216005887 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869216005888 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 869216005889 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216005890 motif II; other site 869216005891 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 869216005892 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 869216005893 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 869216005894 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 869216005895 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869216005896 catalytic residue [active] 869216005897 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 869216005898 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 869216005899 active site 869216005900 catalytic motif [active] 869216005901 Zn binding site [ion binding]; other site 869216005902 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 869216005903 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869216005904 active site 869216005905 HIGH motif; other site 869216005906 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869216005907 active site 869216005908 KMSKS motif; other site 869216005909 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 869216005910 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 869216005911 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 869216005912 active site 869216005913 dimer interface [polypeptide binding]; other site 869216005914 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 869216005915 dimer interface [polypeptide binding]; other site 869216005916 active site 869216005917 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 869216005918 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 869216005919 catalytic triad [active] 869216005920 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869216005921 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869216005922 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216005923 Walker A/P-loop; other site 869216005924 ATP binding site [chemical binding]; other site 869216005925 Q-loop/lid; other site 869216005926 ABC transporter signature motif; other site 869216005927 Walker B; other site 869216005928 D-loop; other site 869216005929 H-loop/switch region; other site 869216005931 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869216005932 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869216005933 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216005934 Walker A/P-loop; other site 869216005935 ATP binding site [chemical binding]; other site 869216005936 Q-loop/lid; other site 869216005937 ABC transporter signature motif; other site 869216005938 Walker B; other site 869216005939 D-loop; other site 869216005940 H-loop/switch region; other site 869216005941 DNA mismatch repair protein MutS; Region: mutS1; TIGR01070 869216005942 MutS domain I; Region: MutS_I; pfam01624 869216005943 MutS domain II; Region: MutS_II; pfam05188 869216005944 MutS domain III; Region: MutS_III; pfam05192 869216005945 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 869216005946 Walker A/P-loop; other site 869216005947 ATP binding site [chemical binding]; other site 869216005948 Q-loop/lid; other site 869216005949 ABC transporter signature motif; other site 869216005950 Walker B; other site 869216005951 D-loop; other site 869216005952 H-loop/switch region; other site 869216005953 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869216005954 arginine repressor; Region: argR_whole; TIGR01529 869216005955 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869216005956 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 869216005957 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 869216005958 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 869216005959 active site 869216005960 HIGH motif; other site 869216005961 KMSK motif region; other site 869216005962 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 869216005963 tRNA binding surface [nucleotide binding]; other site 869216005964 anticodon binding site; other site 869216005966 Uncharacterized conserved protein [Function unknown]; Region: COG3542 869216005967 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869216005968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869216005969 active site 869216005970 phosphorylation site [posttranslational modification] 869216005971 intermolecular recognition site; other site 869216005972 dimerization interface [polypeptide binding]; other site 869216005973 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869216005974 DNA binding site [nucleotide binding] 869216005975 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 869216005976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869216005977 dimer interface [polypeptide binding]; other site 869216005978 phosphorylation site [posttranslational modification] 869216005979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869216005980 ATP binding site [chemical binding]; other site 869216005981 G-X-G motif; other site 869216005982 PBP superfamily domain; Region: PBP_like_2; cl17296 869216005983 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 869216005984 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 869216005985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216005986 dimer interface [polypeptide binding]; other site 869216005987 conserved gate region; other site 869216005988 putative PBP binding loops; other site 869216005989 ABC-ATPase subunit interface; other site 869216005990 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 869216005991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216005992 dimer interface [polypeptide binding]; other site 869216005993 conserved gate region; other site 869216005994 putative PBP binding loops; other site 869216005995 ABC-ATPase subunit interface; other site 869216005996 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 869216005997 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869216005998 Walker A/P-loop; other site 869216005999 ATP binding site [chemical binding]; other site 869216006000 Q-loop/lid; other site 869216006001 ABC transporter signature motif; other site 869216006002 Walker B; other site 869216006003 D-loop; other site 869216006004 H-loop/switch region; other site 869216006005 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 869216006006 PhoU domain; Region: PhoU; pfam01895 869216006007 PhoU domain; Region: PhoU; pfam01895 869216006009 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869216006010 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216006011 non-specific DNA binding site [nucleotide binding]; other site 869216006012 salt bridge; other site 869216006013 sequence-specific DNA binding site [nucleotide binding]; other site 869216006014 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 869216006015 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 869216006016 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 869216006017 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 869216006018 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 869216006019 active site 869216006020 tetramer interface; other site 869216006021 Rhomboid family; Region: Rhomboid; pfam01694 869216006022 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 869216006023 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 869216006024 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 869216006025 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 869216006026 metal binding site [ion binding]; metal-binding site 869216006027 putative dimer interface [polypeptide binding]; other site 869216006028 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 869216006029 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 869216006030 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 869216006031 trimer interface [polypeptide binding]; other site 869216006032 active site 869216006033 substrate binding site [chemical binding]; other site 869216006034 CoA binding site [chemical binding]; other site 869216006035 EamA-like transporter family; Region: EamA; pfam00892 869216006036 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 869216006037 Transglycosylase; Region: Transgly; pfam00912 869216006038 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869216006039 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 869216006040 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 869216006041 active site 869216006042 HIGH motif; other site 869216006043 dimer interface [polypeptide binding]; other site 869216006044 KMSKS motif; other site 869216006045 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869216006046 RNA binding surface [nucleotide binding]; other site 869216006047 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 869216006048 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869216006049 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869216006050 motif II; other site 869216006051 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 869216006052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869216006053 S-adenosylmethionine binding site [chemical binding]; other site 869216006054 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 869216006055 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869216006056 4-alpha-glucanotransferase; Provisional; Region: PRK14508 869216006057 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 869216006058 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869216006059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216006060 dimer interface [polypeptide binding]; other site 869216006061 conserved gate region; other site 869216006062 putative PBP binding loops; other site 869216006063 ABC-ATPase subunit interface; other site 869216006064 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869216006065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869216006066 dimer interface [polypeptide binding]; other site 869216006067 conserved gate region; other site 869216006068 putative PBP binding loops; other site 869216006069 ABC-ATPase subunit interface; other site 869216006070 Predicted integral membrane protein [Function unknown]; Region: COG5521 869216006071 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869216006072 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869216006073 DNA binding site [nucleotide binding] 869216006074 domain linker motif; other site 869216006075 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 869216006076 putative dimerization interface [polypeptide binding]; other site 869216006077 putative ligand binding site [chemical binding]; other site 869216006078 Uncharacterized conserved protein [Function unknown]; Region: COG1284 869216006079 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869216006080 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869216006081 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 869216006082 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 869216006083 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 869216006084 dimer interface [polypeptide binding]; other site 869216006085 anticodon binding site; other site 869216006086 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869216006087 homodimer interface [polypeptide binding]; other site 869216006088 motif 1; other site 869216006089 active site 869216006090 motif 2; other site 869216006091 GAD domain; Region: GAD; pfam02938 869216006092 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869216006093 motif 3; other site 869216006094 CAAX protease self-immunity; Region: Abi; pfam02517 869216006095 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 869216006096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216006097 non-specific DNA binding site [nucleotide binding]; other site 869216006098 salt bridge; other site 869216006099 sequence-specific DNA binding site [nucleotide binding]; other site 869216006100 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 869216006101 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 869216006102 dimer interface [polypeptide binding]; other site 869216006103 motif 1; other site 869216006104 active site 869216006105 motif 2; other site 869216006106 motif 3; other site 869216006107 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 869216006108 anticodon binding site; other site 869216006109 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869216006110 non-specific DNA binding site [nucleotide binding]; other site 869216006111 salt bridge; other site 869216006112 sequence-specific DNA binding site [nucleotide binding]; other site 869216006113 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869216006114 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 869216006115 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 869216006116 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 869216006117 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869216006118 PYR/PP interface [polypeptide binding]; other site 869216006119 dimer interface [polypeptide binding]; other site 869216006120 TPP binding site [chemical binding]; other site 869216006121 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869216006122 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869216006123 TPP-binding site [chemical binding]; other site 869216006124 dimer interface [polypeptide binding]; other site 869216006125 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 869216006126 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 869216006127 active site 869216006128 P-loop; other site 869216006129 phosphorylation site [posttranslational modification] 869216006130 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869216006131 PRD domain; Region: PRD; pfam00874 869216006132 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869216006133 active site 869216006134 P-loop; other site 869216006135 phosphorylation site [posttranslational modification] 869216006136 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869216006137 active site 869216006138 phosphorylation site [posttranslational modification] 869216006139 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 869216006140 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 869216006141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 869216006142 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 869216006143 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 869216006144 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 869216006145 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869216006146 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006147 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006148 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006149 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006150 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006151 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006152 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006154 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 869216006155 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869216006157 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 869216006158 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 869216006159 putative active site [active] 869216006160 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869216006161 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869216006162 nucleotide binding site [chemical binding]; other site 869216006163 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 869216006164 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 869216006165 active site 869216006166 metal binding site [ion binding]; metal-binding site 869216006167 homodimer interface [polypeptide binding]; other site 869216006168 catalytic site [active] 869216006169 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 869216006170 Uncharacterized conserved protein [Function unknown]; Region: COG3538 869216006171 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 869216006172 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 869216006173 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 869216006174 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 869216006175 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 869216006176 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869216006177 Calx-beta domain; Region: Calx-beta; cl02522 869216006178 arginine deiminase; Provisional; Region: PRK01388 869216006179 ornithine carbamoyltransferase; Validated; Region: PRK02102 869216006180 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869216006181 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869216006182 carbamate kinase; Reviewed; Region: PRK12686 869216006183 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 869216006184 putative substrate binding site [chemical binding]; other site 869216006185 nucleotide binding site [chemical binding]; other site 869216006186 nucleotide binding site [chemical binding]; other site 869216006187 homodimer interface [polypeptide binding]; other site 869216006188 Predicted membrane protein [Function unknown]; Region: COG1288 869216006189 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 869216006190 hypothetical protein; Provisional; Region: PRK07205 869216006191 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 869216006192 active site 869216006193 metal binding site [ion binding]; metal-binding site 869216006196 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 869216006197 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 869216006198 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 869216006199 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 869216006200 dimer interface [polypeptide binding]; other site 869216006201 active site 869216006202 metal binding site [ion binding]; metal-binding site 869216006203 L-fucose isomerase; Provisional; Region: fucI; PRK10991 869216006204 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 869216006205 hexamer (dimer of trimers) interface [polypeptide binding]; other site 869216006206 trimer interface [polypeptide binding]; other site 869216006207 substrate binding site [chemical binding]; other site 869216006208 Mn binding site [ion binding]; other site 869216006209 Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306 869216006210 Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307 869216006211 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 869216006212 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 869216006213 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 869216006214 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869216006215 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 869216006216 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869216006217 active site 869216006218 phosphorylation site [posttranslational modification] 869216006219 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869216006220 active pocket/dimerization site; other site 869216006221 active site 869216006222 phosphorylation site [posttranslational modification] 869216006223 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 869216006224 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 869216006225 intersubunit interface [polypeptide binding]; other site 869216006226 active site 869216006227 Zn2+ binding site [ion binding]; other site 869216006228 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 869216006229 N- and C-terminal domain interface [polypeptide binding]; other site 869216006230 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 869216006231 active site 869216006232 putative catalytic site [active] 869216006233 metal binding site [ion binding]; metal-binding site 869216006234 ATP binding site [chemical binding]; other site 869216006235 carbohydrate binding site [chemical binding]; other site 869216006236 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869216006237 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 869216006238 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869216006239 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869216006240 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 869216006241 metal binding site [ion binding]; metal-binding site 869216006242 YodA lipocalin-like domain; Region: YodA; pfam09223 869216006243 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 869216006244 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869216006245 ABC-ATPase subunit interface; other site 869216006246 dimer interface [polypeptide binding]; other site 869216006247 putative PBP binding regions; other site 869216006248 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869216006249 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 869216006250 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869216006251 putative DNA binding site [nucleotide binding]; other site 869216006252 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 869216006253 DltD N-terminal region; Region: DltD_N; pfam04915 869216006254 DltD central region; Region: DltD_M; pfam04918 869216006255 DltD C-terminal region; Region: DltD_C; pfam04914 869216006256 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 869216006257 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 869216006258 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 869216006259 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 869216006260 acyl-activating enzyme (AAE) consensus motif; other site 869216006261 AMP binding site [chemical binding]; other site 869216006262 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869216006263 putative substrate translocation pore; other site 869216006264 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 869216006265 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 869216006266 putative active site [active] 869216006267 putative NTP binding site [chemical binding]; other site 869216006268 putative nucleic acid binding site [nucleotide binding]; other site 869216006269 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 869216006270 amphipathic channel; other site 869216006271 Asn-Pro-Ala signature motifs; other site 869216006272 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 869216006273 glycerol kinase; Provisional; Region: glpK; PRK00047 869216006274 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 869216006275 N- and C-terminal domain interface [polypeptide binding]; other site 869216006276 active site 869216006277 MgATP binding site [chemical binding]; other site 869216006278 catalytic site [active] 869216006279 metal binding site [ion binding]; metal-binding site 869216006280 glycerol binding site [chemical binding]; other site 869216006281 homotetramer interface [polypeptide binding]; other site 869216006282 homodimer interface [polypeptide binding]; other site 869216006283 FBP binding site [chemical binding]; other site 869216006284 protein IIAGlc interface [polypeptide binding]; other site 869216006285 Mga helix-turn-helix domain; Region: Mga; pfam05043 869216006286 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 869216006287 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 869216006288 dimerization interface [polypeptide binding]; other site 869216006289 domain crossover interface; other site 869216006290 redox-dependent activation switch; other site 869216006291 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 869216006292 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 869216006293 FMN binding site [chemical binding]; other site 869216006294 active site 869216006295 catalytic residues [active] 869216006296 substrate binding site [chemical binding]; other site 869216006297 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869216006298 RICH domain; Region: RICH; pfam05062 869216006299 RICH domain; Region: RICH; pfam05062 869216006300 Cornifin (SPRR) family; Region: Cornifin; pfam02389 869216006301 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006302 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006303 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006304 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006305 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006306 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006307 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006308 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 869216006309 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006310 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 869216006312 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869216006313 HAMP domain; Region: HAMP; pfam00672 869216006314 dimerization interface [polypeptide binding]; other site 869216006315 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869216006316 dimer interface [polypeptide binding]; other site 869216006317 phosphorylation site [posttranslational modification] 869216006318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869216006319 ATP binding site [chemical binding]; other site 869216006320 Mg2+ binding site [ion binding]; other site 869216006321 G-X-G motif; other site 869216006322 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869216006323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869216006324 active site 869216006325 phosphorylation site [posttranslational modification] 869216006326 intermolecular recognition site; other site 869216006327 dimerization interface [polypeptide binding]; other site 869216006328 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869216006329 DNA binding site [nucleotide binding] 869216006330 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 869216006331 Clp amino terminal domain; Region: Clp_N; pfam02861 869216006332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216006333 Walker A motif; other site 869216006334 ATP binding site [chemical binding]; other site 869216006335 Walker B motif; other site 869216006336 arginine finger; other site 869216006337 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869216006338 Walker A motif; other site 869216006339 ATP binding site [chemical binding]; other site 869216006340 Walker B motif; other site 869216006341 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869216006342 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 869216006343 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 869216006344 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 869216006345 Walker A/P-loop; other site 869216006346 ATP binding site [chemical binding]; other site 869216006347 Q-loop/lid; other site 869216006348 ABC transporter signature motif; other site 869216006349 Walker B; other site 869216006350 D-loop; other site 869216006351 H-loop/switch region; other site 869216006352 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 869216006353 NMT1/THI5 like; Region: NMT1; pfam09084 869216006354 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 869216006355 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 869216006356 Uncharacterized conserved protein [Function unknown]; Region: COG0011 869216006357 Surface antigen [General function prediction only]; Region: COG3942 869216006358 CHAP domain; Region: CHAP; pfam05257 869216006359 Bacterial SH3 domain; Region: SH3_5; pfam08460 869216006360 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869216006361 Bacterial SH3 domain; Region: SH3_5; pfam08460 869216006362 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869216006363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 869216006364 replicative DNA helicase; Provisional; Region: PRK05748 869216006365 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 869216006366 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 869216006367 Walker A motif; other site 869216006368 ATP binding site [chemical binding]; other site 869216006369 Walker B motif; other site 869216006370 DNA binding loops [nucleotide binding] 869216006371 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 869216006372 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 869216006373 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 869216006374 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 869216006375 DHH family; Region: DHH; pfam01368 869216006376 DHHA1 domain; Region: DHHA1; pfam02272 869216006377 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 869216006378 30S subunit binding site; other site 869216006379 comF family protein; Region: comF; TIGR00201 869216006380 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869216006381 active site 869216006382 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 869216006383 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869216006384 ATP binding site [chemical binding]; other site 869216006385 putative Mg++ binding site [ion binding]; other site 869216006386 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869216006387 nucleotide binding region [chemical binding]; other site 869216006388 ATP-binding site [chemical binding]; other site 869216006389 Uncharacterized conserved protein [Function unknown]; Region: COG1739 869216006390 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 869216006391 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 869216006392 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 869216006393 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 869216006394 dimer interface [polypeptide binding]; other site 869216006395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869216006396 catalytic residue [active] 869216006400 elongation factor Ts; Provisional; Region: tsf; PRK09377 869216006401 UBA/TS-N domain; Region: UBA; pfam00627 869216006402 Elongation factor TS; Region: EF_TS; pfam00889 869216006403 Elongation factor TS; Region: EF_TS; pfam00889 869216006404 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 869216006405 rRNA interaction site [nucleotide binding]; other site 869216006406 S8 interaction site; other site 869216006407 putative laminin-1 binding site; other site 869216006408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 869216006409 Septum formation initiator; Region: DivIC; cl17659 869216006410 Surface antigen [General function prediction only]; Region: COG3942 869216006411 CHAP domain; Region: CHAP; pfam05257 869216006412 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 869216006413 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 869216006414 rod shape-determining protein MreC; Region: MreC; pfam04085 869216006415 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869216006416 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 869216006417 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869216006418 Walker A/P-loop; other site 869216006419 ATP binding site [chemical binding]; other site 869216006420 Q-loop/lid; other site 869216006421 ABC transporter signature motif; other site 869216006422 Walker B; other site 869216006423 D-loop; other site 869216006424 H-loop/switch region; other site 869216006425 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 869216006426 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869216006427 Walker A/P-loop; other site 869216006428 ATP binding site [chemical binding]; other site 869216006429 Q-loop/lid; other site 869216006430 ABC transporter signature motif; other site 869216006431 Walker B; other site 869216006432 D-loop; other site 869216006433 H-loop/switch region; other site 869216006434 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 869216006435 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 869216006436 Helix-turn-helix domain; Region: HTH_25; pfam13413 869216006437 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 869216006438 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869216006439 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 869216006440 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869216006441 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869216006442 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869216006443 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 869216006444 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 869216006445 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 869216006446 Walker A/P-loop; other site 869216006447 ATP binding site [chemical binding]; other site 869216006448 Q-loop/lid; other site 869216006449 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869216006450 ABC transporter signature motif; other site 869216006451 Walker B; other site 869216006452 D-loop; other site 869216006453 H-loop/switch region; other site 869216006454 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 869216006455 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869216006456 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 869216006457 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869216006458 active site 869216006459 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 869216006460 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 869216006461 active site 869216006462 HIGH motif; other site 869216006463 dimer interface [polypeptide binding]; other site 869216006464 KMSKS motif; other site 869216006465 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 869216006466 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869216006467 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869216006468 ABC transporter; Region: ABC_tran_2; pfam12848 869216006469 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869216006470 Predicted membrane protein [Function unknown]; Region: COG4485 869216006471 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 869216006472 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 869216006473 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869216006474 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869216006475 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869216006476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869216006477 active site 869216006478 phosphorylation site [posttranslational modification] 869216006479 intermolecular recognition site; other site 869216006480 dimerization interface [polypeptide binding]; other site 869216006481 LytTr DNA-binding domain; Region: LytTR; pfam04397 869216006482 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869216006483 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 869216006484 COMC family; Region: ComC; pfam03047 869216006485 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 869216006486 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 869216006487 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869216006488 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869216006489 protein binding site [polypeptide binding]; other site 869216006490 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 869216006491 ParB-like nuclease domain; Region: ParBc; pfam02195 869216006492 KorB domain; Region: KorB; pfam08535