-- dump date 20140620_084803 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_002735124.1 225853612 7680620 197..1558 1 NC_012466.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1558 dnaA 7680620 dnaA Streptococcus pneumoniae JJA chromosomal replication initiation protein YP_002735124.1 197 D 488222 CDS YP_002735125.1 225853613 7679914 1717..2853 1 NC_012466.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2853 dnaN 7679914 dnaN Streptococcus pneumoniae JJA DNA polymerase III subunit beta YP_002735125.1 1717 D 488222 CDS YP_002735126.1 225853614 7679319 2918..3112 1 NC_012466.1 identified by match to protein family HMM PF06107; hypothetical protein 3112 7679319 SPJ_0003 Streptococcus pneumoniae JJA hypothetical protein YP_002735126.1 2918 D 488222 CDS YP_002735127.1 225853615 7678691 3196..4311 1 NC_012466.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 4311 ychF 7678691 ychF Streptococcus pneumoniae JJA GTP-dependent nucleic acid-binding protein EngD YP_002735127.1 3196 D 488222 CDS YP_002735128.1 225853616 7680072 4383..4952 1 NC_012466.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4952 pth 7680072 pth Streptococcus pneumoniae JJA peptidyl-tRNA hydrolase YP_002735128.1 4383 D 488222 CDS YP_002735129.1 225853617 7679721 4953..8462 1 NC_012466.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580; transcription-repair coupling factor 8462 mfd 7679721 mfd Streptococcus pneumoniae JJA transcription-repair coupling factor YP_002735129.1 4953 D 488222 CDS YP_002735130.1 225853618 7678855 8520..8786 1 NC_012466.1 identified by match to protein family HMM PF01479; ribosome-associated heat shock protein implicated in the recycling of the 50S subunit 8786 7678855 SPJ_0007 Streptococcus pneumoniae JJA ribosome-associated heat shock protein implicated in the recycling of the 50S subunit YP_002735130.1 8520 D 488222 CDS YP_002735131.1 225853619 7678515 8779..9147 1 NC_012466.1 identified by match to protein family HMM PF04977; septum formation initiator 9147 7678515 SPJ_0008 Streptococcus pneumoniae JJA septum formation initiator YP_002735131.1 8779 D 488222 CDS YP_002735132.1 225853620 7679871 9152..9274 1 NC_012466.1 hypothetical protein 9274 7679871 SPJ_0009 Streptococcus pneumoniae JJA hypothetical protein YP_002735132.1 9152 D 488222 CDS YP_002735133.1 225853621 7679256 9267..10535 1 NC_012466.1 beta-lactamase class A 10535 7679256 SPJ_0010 Streptococcus pneumoniae JJA beta-lactamase class A YP_002735133.1 9267 D 488222 CDS YP_002735134.1 225853622 7678742 10532..11809 1 NC_012466.1 identified by match to protein family HMM PF01171; match to protein family HMM TIGR02432; match to protein family HMM TIGR02433; tRNA(Ile)-lysidine synthase (tRNA(Ile)-lysidinesynthetase) (tRNA(Ile)-2-lysyl-cytidine synthase) 11809 7678742 SPJ_0011 Streptococcus pneumoniae JJA tRNA(Ile)-lysidine synthase (tRNA(Ile)-lysidinesynthetase) (tRNA(Ile)-2-lysyl-cytidine synthase) YP_002735134.1 10532 D 488222 CDS YP_002735135.1 225853623 7680315 11813..12355 1 NC_012466.1 identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; hypoxanthine phosphoribosyltransferase 12355 hpt 7680315 hpt Streptococcus pneumoniae JJA hypoxanthine phosphoribosyltransferase YP_002735135.1 11813 D 488222 CDS YP_002735136.1 225853624 7679168 12371..14329 1 NC_012466.1 identified by match to protein family HMM PF00004; match to protein family HMM PF01434; match to protein family HMM PF06480; match to protein family HMM TIGR01241; putative Cell division protease FtsH homolog 14329 7679168 SPJ_0013 Streptococcus pneumoniae JJA putative Cell division protease FtsH homolog YP_002735136.1 12371 D 488222 CDS YP_002735137.1 225853625 7678535 14451..14930 1 NC_012466.1 competence-specific global transcription modulator 14930 7678535 SPJ_0014 Streptococcus pneumoniae JJA competence-specific global transcription modulator YP_002735137.1 14451 D 488222 CDS YP_002735138.1 225853626 7680584 20422..20751 1 NC_012466.1 identified by match to protein family HMM PF01710; transposase 20751 7680584 SPJ_0022 Streptococcus pneumoniae JJA transposase YP_002735138.1 20422 D 488222 CDS YP_002735139.1 225853627 7679950 21178..21312 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 21312 7679950 SPJ_0024 Streptococcus pneumoniae JJA hypothetical protein YP_002735139.1 21178 D 488222 CDS YP_002735140.1 225853628 7679232 complement(21303..21509) 1 NC_012466.1 transposase 21509 7679232 SPJ_0023 Streptococcus pneumoniae JJA transposase YP_002735140.1 21303 R 488222 CDS YP_002735141.1 225853629 7679020 complement(21652..21795) 1 NC_012466.1 transposase 21795 7679020 SPJ_0025 Streptococcus pneumoniae JJA transposase YP_002735141.1 21652 R 488222 CDS YP_002735142.1 225853630 7678745 complement(21843..22049) 1 NC_012466.1 transposase 22049 7678745 SPJ_0026 Streptococcus pneumoniae JJA transposase YP_002735142.1 21843 R 488222 CDS YP_002735143.1 225853631 7679747 22366..22602 1 NC_012466.1 hypothetical protein 22602 7679747 SPJ_0027 Streptococcus pneumoniae JJA hypothetical protein YP_002735143.1 22366 D 488222 CDS YP_002735144.1 225853632 7680224 22791..24119 1 NC_012466.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 24119 purA 7680224 purA Streptococcus pneumoniae JJA adenylosuccinate synthetase YP_002735144.1 22791 D 488222 CDS YP_002735145.1 225853633 7678733 24320..24787 1 NC_012466.1 identified by match to protein family HMM PF00383; tRNA-specific adenosine deaminase 24787 7678733 SPJ_0029 Streptococcus pneumoniae JJA tRNA-specific adenosine deaminase YP_002735145.1 24320 D 488222 CDS YP_002735146.1 225853634 7679266 complement(24996..25712) 1 NC_012466.1 identified by match to protein family HMM PF00589; integrase 25712 7679266 SPJ_0030 Streptococcus pneumoniae JJA integrase YP_002735146.1 24996 R 488222 CDS YP_002735147.1 225853635 7680013 complement(25784..26137) 1 NC_012466.1 integrase 26137 7680013 SPJ_0031 Streptococcus pneumoniae JJA integrase YP_002735147.1 25784 R 488222 CDS YP_002735148.1 225853636 7679569 complement(26192..27262) 1 NC_012466.1 identified by match to protein family HMM PF04313; prophage Lp2 protein 6 27262 7679569 SPJ_0032 Streptococcus pneumoniae JJA prophage Lp2 protein 6 YP_002735148.1 26192 R 488222 CDS YP_002735149.1 225853637 7680041 complement(27279..27659) 1 NC_012466.1 identified by match to protein family HMM PF06114; hypothetical protein 27659 7680041 SPJ_0033 Streptococcus pneumoniae JJA hypothetical protein YP_002735149.1 27279 R 488222 CDS YP_002735150.1 225853638 7678656 complement(27672..27935) 1 NC_012466.1 identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; plasmid addiction system poison protein 27935 7678656 SPJ_0034 Streptococcus pneumoniae JJA plasmid addiction system poison protein YP_002735150.1 27672 R 488222 CDS YP_002735151.1 225853639 7679123 complement(27935..28168) 1 NC_012466.1 hypothetical protein 28168 7679123 SPJ_0035 Streptococcus pneumoniae JJA hypothetical protein YP_002735151.1 27935 R 488222 CDS YP_002735152.1 225853640 7679875 complement(28168..28536) 1 NC_012466.1 identified by match to protein family HMM PF01381; phage transcriptional regulator, Cro/CI family 28536 7679875 SPJ_0036 Streptococcus pneumoniae JJA phage transcriptional regulator, Cro/CI family YP_002735152.1 28168 R 488222 CDS YP_002735153.1 225853641 7679242 28834..28965 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 28965 7679242 SPJ_0037 Streptococcus pneumoniae JJA hypothetical protein YP_002735153.1 28834 D 488222 CDS YP_002735154.1 225853642 7679988 29108..29299 1 NC_012466.1 hypothetical protein 29299 7679988 SPJ_0038 Streptococcus pneumoniae JJA hypothetical protein YP_002735154.1 29108 D 488222 CDS YP_002735155.1 225853643 7680432 29322..29525 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 29525 7680432 SPJ_0039 Streptococcus pneumoniae JJA hypothetical protein YP_002735155.1 29322 D 488222 CDS YP_002735156.1 225853644 7679150 29540..29683 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 29683 7679150 SPJ_0041 Streptococcus pneumoniae JJA hypothetical protein YP_002735156.1 29540 D 488222 CDS YP_002735157.1 225853645 7680528 complement(29680..29847) 1 NC_012466.1 hypothetical protein 29847 7680528 SPJ_0040 Streptococcus pneumoniae JJA hypothetical protein YP_002735157.1 29680 R 488222 CDS YP_002735158.1 225853646 7679488 29918..30232 1 NC_012466.1 identified by match to protein family HMM PF01473; lytic amidase (N-acetylmuramoyl-L-alanine amidase) 30232 7679488 SPJ_0042 Streptococcus pneumoniae JJA lytic amidase (N-acetylmuramoyl-L-alanine amidase) YP_002735158.1 29918 D 488222 CDS YP_002735159.1 225853647 7680156 30322..30471 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 30471 7680156 SPJ_0044 Streptococcus pneumoniae JJA hypothetical protein YP_002735159.1 30322 D 488222 CDS YP_002735160.1 225853648 7679462 complement(30452..30631) 1 NC_012466.1 hypothetical protein 30631 7679462 SPJ_0043 Streptococcus pneumoniae JJA hypothetical protein YP_002735160.1 30452 R 488222 CDS YP_002735161.1 225853649 7678847 31227..31670 1 NC_012466.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 31670 dut 7678847 dut Streptococcus pneumoniae JJA deoxyuridine 5'-triphosphate nucleotidohydrolase YP_002735161.1 31227 D 488222 CDS YP_002735162.1 225853650 7679832 31630..32187 1 NC_012466.1 identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein 32187 7679832 SPJ_0046 Streptococcus pneumoniae JJA phosphoglycerate mutase family protein YP_002735162.1 31630 D 488222 CDS YP_002735163.1 225853651 7678547 32300..33562 1 NC_012466.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 33562 radA 7678547 radA Streptococcus pneumoniae JJA DNA repair protein RadA YP_002735163.1 32300 D 488222 CDS YP_002735164.1 225853652 7678802 33635..34132 1 NC_012466.1 identified by match to protein family HMM PF00484; carbonate dehydratase 34132 7678802 SPJ_0048 Streptococcus pneumoniae JJA carbonate dehydratase YP_002735164.1 33635 D 488222 CDS YP_002735165.1 225853653 7680381 34157..34816 1 NC_012466.1 hypothetical protein 34816 7680381 SPJ_0049 Streptococcus pneumoniae JJA hypothetical protein YP_002735165.1 34157 D 488222 CDS YP_002735166.1 225853654 7679768 34809..34940 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 34940 7679768 SPJ_0050 Streptococcus pneumoniae JJA hypothetical protein YP_002735166.1 34809 D 488222 CDS YP_002735167.1 225853655 7679064 35085..36053 1 NC_012466.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 36053 7679064 SPJ_0051 Streptococcus pneumoniae JJA ribose-phosphate pyrophosphokinase YP_002735167.1 35085 D 488222 CDS YP_002735168.1 225853656 7680383 complement(36175..36468) 1 NC_012466.1 transposase 36468 7680383 SPJ_0052 Streptococcus pneumoniae JJA transposase YP_002735168.1 36175 R 488222 CDS YP_002735169.1 225853657 7680167 complement(36595..36828) 1 NC_012466.1 hypothetical protein 36828 7680167 SPJ_0053 Streptococcus pneumoniae JJA hypothetical protein YP_002735169.1 36595 R 488222 CDS YP_002735170.1 225853658 7679705 complement(36786..37112) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 37112 7679705 SPJ_0054 Streptococcus pneumoniae JJA hypothetical protein YP_002735170.1 36786 R 488222 CDS YP_002735171.1 225853659 7678513 complement(37152..37466) 1 NC_012466.1 hypothetical protein 37466 7678513 SPJ_0055 Streptococcus pneumoniae JJA hypothetical protein YP_002735171.1 37152 R 488222 CDS YP_002735172.1 225853660 7678873 37758..40391 1 NC_012466.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 40391 7678873 SPJ_0056 Streptococcus pneumoniae JJA DNA polymerase I YP_002735172.1 37758 D 488222 CDS YP_002735173.1 225853661 7680162 40476..40913 1 NC_012466.1 identified by match to protein family HMM PF02629; CoA binding protein 40913 7680162 SPJ_0057 Streptococcus pneumoniae JJA CoA binding protein YP_002735173.1 40476 D 488222 CDS YP_002735174.1 225853662 7679848 complement(41376..42386) 1 NC_012466.1 identified by match to protein family HMM PF03601; membrane protein Spr0034 42386 7679848 SPJ_0058 Streptococcus pneumoniae JJA membrane protein Spr0034 YP_002735174.1 41376 R 488222 CDS YP_002735175.1 225853663 7678627 42535..43704 1 NC_012466.1 catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 43704 7678627 SPJ_0059 Streptococcus pneumoniae JJA aromatic amino acid aminotransferase YP_002735175.1 42535 D 488222 CDS YP_002735176.1 225853664 7678663 43701..44471 1 NC_012466.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 44471 recO 7678663 recO Streptococcus pneumoniae JJA DNA repair protein RecO YP_002735176.1 43701 D 488222 CDS YP_002735177.1 225853665 7680376 44468..45460 1 NC_012466.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 45460 plsX 7680376 plsX Streptococcus pneumoniae JJA putative glycerol-3-phosphate acyltransferase PlsX YP_002735177.1 44468 D 488222 CDS YP_002735178.1 225853666 7679921 45466..45699 1 NC_012466.1 hypothetical protein 45699 7679921 SPJ_0062 Streptococcus pneumoniae JJA hypothetical protein YP_002735178.1 45466 D 488222 CDS YP_002735179.1 225853667 7679427 45742..46035 1 NC_012466.1 mobile genetic element 46035 7679427 SPJ_0063 Streptococcus pneumoniae JJA mobile genetic element YP_002735179.1 45742 D 488222 CDS YP_002735180.1 225853668 7678652 46238..46468 1 NC_012466.1 identified by match to protein family HMM TIGR01847; hypothetical protein 46468 7678652 SPJ_0064 Streptococcus pneumoniae JJA hypothetical protein YP_002735180.1 46238 D 488222 CDS YP_002735181.1 225853669 7680106 46471..46596 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 46596 7680106 SPJ_0065 Streptococcus pneumoniae JJA hypothetical protein YP_002735181.1 46471 D 488222 CDS YP_002735182.1 225853670 7680406 47004..47198 1 NC_012466.1 hypothetical protein 47198 7680406 SPJ_0066 Streptococcus pneumoniae JJA hypothetical protein YP_002735182.1 47004 D 488222 CDS YP_002735183.1 225853671 7679135 47219..48112 1 NC_012466.1 identified by match to protein family HMM PF01381; XRE family transcriptional regulator 48112 7679135 SPJ_0067 Streptococcus pneumoniae JJA XRE family transcriptional regulator YP_002735183.1 47219 D 488222 CDS YP_002735184.1 225853672 7679376 48655..48951 1 NC_012466.1 hypothetical protein 48951 7679376 SPJ_0068 Streptococcus pneumoniae JJA hypothetical protein YP_002735184.1 48655 D 488222 CDS YP_002735185.1 225853673 7679852 48958..50094 1 NC_012466.1 hypothetical protein 50094 7679852 SPJ_0069 Streptococcus pneumoniae JJA hypothetical protein YP_002735185.1 48958 D 488222 CDS YP_002735186.1 225853674 7680541 50331..50573 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 50573 7680541 SPJ_0070 Streptococcus pneumoniae JJA hypothetical protein YP_002735186.1 50331 D 488222 CDS YP_002735187.1 225853675 7678853 50570..51166 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 51166 7678853 SPJ_0071 Streptococcus pneumoniae JJA hypothetical protein YP_002735187.1 50570 D 488222 CDS YP_002735188.1 225853676 7679656 51147..51638 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 51638 7679656 SPJ_0072 Streptococcus pneumoniae JJA hypothetical protein YP_002735188.1 51147 D 488222 CDS YP_002735189.1 225853677 7678394 52018..54171 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193; transport/processing ATP-binding protein ComA 54171 7678394 SPJ_0073 Streptococcus pneumoniae JJA transport/processing ATP-binding protein ComA YP_002735189.1 52018 D 488222 CDS YP_002735190.1 225853678 7678989 54184..55533 1 NC_012466.1 identified by match to protein family HMM TIGR01000; transport protein ComB 55533 7678989 SPJ_0074 Streptococcus pneumoniae JJA transport protein ComB YP_002735190.1 54184 D 488222 CDS YP_002735191.1 225853679 7679600 55703..56410 1 NC_012466.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 56410 purC 7679600 purC Streptococcus pneumoniae JJA phosphoribosylaminoimidazole-succinocarboxamide synthase YP_002735191.1 55703 D 488222 CDS YP_002735192.1 225853680 7680524 56421..56555 1 NC_012466.1 phosphoribosylaminoimidazole-succinocarboxamide synthase (saicar synthetase) 56555 7680524 SPJ_0076 Streptococcus pneumoniae JJA phosphoribosylaminoimidazole-succinocarboxamide synthase (saicar synthetase) YP_002735192.1 56421 D 488222 CDS YP_002735193.1 225853681 7680496 56612..60337 1 NC_012466.1 identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857; phosphoribosylformylglycinamidine synthase 60337 7680496 SPJ_0077 Streptococcus pneumoniae JJA phosphoribosylformylglycinamidine synthase YP_002735193.1 56612 D 488222 CDS YP_002735194.1 225853682 7678681 60430..61872 1 NC_012466.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 61872 purF 7678681 purF Streptococcus pneumoniae JJA amidophosphoribosyltransferase YP_002735194.1 60430 D 488222 CDS YP_002735195.1 225853683 7678728 61909..62931 1 NC_012466.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 62931 purM 7678728 purM Streptococcus pneumoniae JJA phosphoribosylaminoimidazole synthetase YP_002735195.1 61909 D 488222 CDS YP_002735196.1 225853684 7680192 62928..63473 1 NC_012466.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 63473 purN 7680192 purN Streptococcus pneumoniae JJA phosphoribosylglycinamide formyltransferase YP_002735196.1 62928 D 488222 CDS YP_002735197.1 225853685 7680016 63557..64066 1 NC_012466.1 identified by match to protein family HMM PF04892; teicoplanin resistance protein 64066 7680016 SPJ_0081 Streptococcus pneumoniae JJA teicoplanin resistance protein YP_002735197.1 63557 D 488222 CDS YP_002735198.1 225853686 7679229 64091..65638 1 NC_012466.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 65638 purH 7679229 purH Streptococcus pneumoniae JJA bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_002735198.1 64091 D 488222 CDS YP_002735199.1 225853687 7679790 65760..67022 1 NC_012466.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 67022 purD 7679790 purD Streptococcus pneumoniae JJA phosphoribosylamine--glycine ligase YP_002735199.1 65760 D 488222 CDS YP_002735200.1 225853688 7679437 67425..67913 1 NC_012466.1 identified by match to protein family HMM PF00731; match to protein family HMM TIGR01162; phosphoribosylaminoimidazole carboxylase, catalytic subunit 67913 purE 7679437 purE Streptococcus pneumoniae JJA phosphoribosylaminoimidazole carboxylase, catalytic subunit YP_002735200.1 67425 D 488222 CDS YP_002735201.1 225853689 7678819 67900..68973 1 NC_012466.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 68973 purK 7678819 purK Streptococcus pneumoniae JJA phosphoribosylaminoimidazole carboxylase ATPase subunit YP_002735201.1 67900 D 488222 CDS YP_002735202.1 225853690 7678456 68996..71383 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 71383 7678456 SPJ_0086 Streptococcus pneumoniae JJA hypothetical protein YP_002735202.1 68996 D 488222 CDS YP_002735203.1 225853691 7680277 71556..72854 1 NC_012466.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 72854 purB 7680277 purB Streptococcus pneumoniae JJA adenylosuccinate lyase YP_002735203.1 71556 D 488222 CDS YP_002735204.1 225853692 7679542 complement(72909..76847) 1 NC_012466.1 identified by match to protein family HMM PF00728; match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-N-acetylhexosaminidase 76847 7679542 SPJ_0088 Streptococcus pneumoniae JJA beta-N-acetylhexosaminidase YP_002735204.1 72909 R 488222 CDS YP_002735205.1 225853693 7679108 complement(77162..77905) 1 NC_012466.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 77905 7679108 SPJ_0089 Streptococcus pneumoniae JJA GntR family transcriptional regulator YP_002735205.1 77162 R 488222 CDS YP_002735206.1 225853694 7678636 78226..80013 1 NC_012466.1 identified by match to protein family HMM PF01301; match to protein family HMM PF02449; beta-galactosidase (Lactase) 80013 7678636 SPJ_0090 Streptococcus pneumoniae JJA beta-galactosidase (Lactase) YP_002735206.1 78226 D 488222 CDS YP_002735207.1 225853695 7680088 80010..80486 1 NC_012466.1 identified by match to protein family HMM PF03830; phosphotransferase system sugar-specific eiib component 80486 7680088 SPJ_0091 Streptococcus pneumoniae JJA phosphotransferase system sugar-specific eiib component YP_002735207.1 80010 D 488222 CDS YP_002735208.1 225853696 7679045 80514..81419 1 NC_012466.1 identified by match to protein family HMM PF03609; PTS system, IIC component 81419 7679045 SPJ_0092 Streptococcus pneumoniae JJA PTS system, IIC component YP_002735208.1 80514 D 488222 CDS YP_002735209.1 225853697 7679033 81406..82221 1 NC_012466.1 identified by match to protein family HMM PF03613; PTS system, IID component 82221 7679033 SPJ_0093 Streptococcus pneumoniae JJA PTS system, IID component YP_002735209.1 81406 D 488222 CDS YP_002735210.1 225853698 7678445 82228..82632 1 NC_012466.1 identified by match to protein family HMM PF03610; phosphotransferase system sugar-specific EII component 82632 7678445 SPJ_0094 Streptococcus pneumoniae JJA phosphotransferase system sugar-specific EII component YP_002735210.1 82228 D 488222 CDS YP_002735211.1 225853699 7680292 82885..84051 1 NC_012466.1 identified by match to protein family HMM PF01380; putative tagatose-6-phosphate ketose/aldose isomerase 84051 7680292 SPJ_0095 Streptococcus pneumoniae JJA putative tagatose-6-phosphate ketose/aldose isomerase YP_002735211.1 82885 D 488222 CDS YP_002735212.1 225853700 7679307 84167..85204 1 NC_012466.1 identified by match to protein family HMM PF01263; aldose 1-epimerase 85204 7679307 SPJ_0096 Streptococcus pneumoniae JJA aldose 1-epimerase YP_002735212.1 84167 D 488222 CDS YP_002735213.1 225853701 7680504 85411..86265 1 NC_012466.1 identified by match to protein family HMM PF00903; glyoxalase family protein 86265 7680504 SPJ_0097 Streptococcus pneumoniae JJA glyoxalase family protein YP_002735213.1 85411 D 488222 CDS YP_002735214.1 225853702 7679959 86415..86672 1 NC_012466.1 identified by match to protein family HMM PF02583; hypothetical protein 86672 7679959 SPJ_0098 Streptococcus pneumoniae JJA hypothetical protein YP_002735214.1 86415 D 488222 CDS YP_002735215.1 225853703 7679272 complement(87103..87381) 1 NC_012466.1 identified by match to protein family HMM PF00581; hypothetical protein 87381 7679272 SPJ_0099 Streptococcus pneumoniae JJA hypothetical protein YP_002735215.1 87103 R 488222 CDS YP_002735216.1 225853704 7679633 complement(87371..87490) 1 NC_012466.1 coenzyme A disulfide reductase 87490 7679633 SPJ_0100 Streptococcus pneumoniae JJA coenzyme A disulfide reductase YP_002735216.1 87371 R 488222 CDS YP_002735217.1 225853705 7680085 87603..88367 1 NC_012466.1 identified by match to protein family HMM PF01048; phosphorylase, Pnp/Udp family 88367 7680085 SPJ_0101 Streptococcus pneumoniae JJA phosphorylase, Pnp/Udp family YP_002735217.1 87603 D 488222 CDS YP_002735218.1 225853706 7678622 complement(88607..88849) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 88849 7678622 SPJ_0102 Streptococcus pneumoniae JJA hypothetical protein YP_002735218.1 88607 R 488222 CDS YP_002735219.1 225853707 7678522 89067..90446 1 NC_012466.1 identified by match to protein family HMM PF02386; Trk transporter membrane-spanning protein - K+ transport 90446 7678522 SPJ_0103 Streptococcus pneumoniae JJA Trk transporter membrane-spanning protein - K+ transport YP_002735219.1 89067 D 488222 CDS YP_002735220.1 225853708 7679170 90460..91125 1 NC_012466.1 identified by match to protein family HMM PF02254; potassium uptake protein, Trk family 91125 7679170 SPJ_0104 Streptococcus pneumoniae JJA potassium uptake protein, Trk family YP_002735220.1 90460 D 488222 CDS YP_002735221.1 225853709 7680538 91260..91463 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 91463 7680538 SPJ_0105 Streptococcus pneumoniae JJA hypothetical protein YP_002735221.1 91260 D 488222 CDS YP_002735222.1 225853710 7679760 92657..95230 1 NC_012466.1 identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; cell wall surface anchor family protein 95230 7679760 SPJ_0108 Streptococcus pneumoniae JJA cell wall surface anchor family protein YP_002735222.1 92657 D 488222 CDS YP_002735223.1 225853711 7678836 95397..96095 1 NC_012466.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator SaeR 96095 7678836 SPJ_0109 Streptococcus pneumoniae JJA response regulator SaeR YP_002735223.1 95397 D 488222 CDS YP_002735224.1 225853712 7680285 96092..97144 1 NC_012466.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; histidine kinase 97144 7680285 SPJ_0110 Streptococcus pneumoniae JJA histidine kinase YP_002735224.1 96092 D 488222 CDS YP_002735225.1 225853713 7679792 97339..97950 1 NC_012466.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 97950 rpsD 7679792 rpsD Streptococcus pneumoniae JJA 30S ribosomal protein S4 YP_002735225.1 97339 D 488222 CDS YP_002735226.1 225853714 7679456 98136..98294 1 NC_012466.1 transposase 98294 7679456 SPJ_0112 Streptococcus pneumoniae JJA transposase YP_002735226.1 98136 D 488222 CDS YP_002735227.1 225853715 7678971 98717..98977 1 NC_012466.1 hypothetical protein 98977 7678971 SPJ_0113 Streptococcus pneumoniae JJA hypothetical protein YP_002735227.1 98717 D 488222 CDS YP_002735228.1 225853716 7680424 98931..99152 1 NC_012466.1 hypothetical protein 99152 7680424 SPJ_0114 Streptococcus pneumoniae JJA hypothetical protein YP_002735228.1 98931 D 488222 CDS YP_002735229.1 225853717 7679980 99471..100400 1 NC_012466.1 identified by match to protein family HMM PF00528; ABC transporter permease 100400 7679980 SPJ_0115 Streptococcus pneumoniae JJA ABC transporter permease YP_002735229.1 99471 D 488222 CDS YP_002735230.1 225853718 7679690 100414..101337 1 NC_012466.1 identified by match to protein family HMM PF00528; protein LplC 101337 7679690 SPJ_0116 Streptococcus pneumoniae JJA protein LplC YP_002735230.1 100414 D 488222 CDS YP_002735231.1 225853719 7679324 101595..103070 1 NC_012466.1 identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein 103070 7679324 SPJ_0117 Streptococcus pneumoniae JJA ABC transporter substrate-binding protein YP_002735231.1 101595 D 488222 CDS YP_002735232.1 225853720 7678387 103342..104328 1 NC_012466.1 identified by match to protein family HMM PF00581; hypothetical protein 104328 7678387 SPJ_0118 Streptococcus pneumoniae JJA hypothetical protein YP_002735232.1 103342 D 488222 CDS YP_002735233.1 225853721 7679345 104450..105310 1 NC_012466.1 hypothetical protein 105310 7679345 SPJ_0119 Streptococcus pneumoniae JJA hypothetical protein YP_002735233.1 104450 D 488222 CDS YP_002735234.1 225853722 7679577 complement(105382..106446) 1 NC_012466.1 hypothetical protein 106446 7679577 SPJ_0120 Streptococcus pneumoniae JJA hypothetical protein YP_002735234.1 105382 R 488222 CDS YP_002735235.1 225853723 7680070 complement(106509..107420) 1 NC_012466.1 hypothetical protein 107420 7680070 SPJ_0121 Streptococcus pneumoniae JJA hypothetical protein YP_002735235.1 106509 R 488222 CDS YP_002735236.1 225853724 7679068 complement(107413..108006) 1 NC_012466.1 hypothetical protein 108006 7679068 SPJ_0122 Streptococcus pneumoniae JJA hypothetical protein YP_002735236.1 107413 R 488222 CDS YP_002735237.1 225853725 7678715 complement(107993..108319) 1 NC_012466.1 identified by match to protein family HMM PF03551; transcription regulator 108319 7678715 SPJ_0123 Streptococcus pneumoniae JJA transcription regulator YP_002735237.1 107993 R 488222 CDS YP_002735238.1 225853726 7680058 complement(108458..109624) 1 NC_012466.1 identified by match to protein family HMM PF07690; cyanate permease 109624 7680058 SPJ_0124 Streptococcus pneumoniae JJA cyanate permease YP_002735238.1 108458 R 488222 CDS YP_002735239.1 225853727 7679715 109775..110839 1 NC_012466.1 identified by match to protein family HMM PF00535; glycosyl transferase 110839 7679715 SPJ_0125 Streptococcus pneumoniae JJA glycosyl transferase YP_002735239.1 109775 D 488222 CDS YP_002735240.1 225853728 7678818 110881..112731 1 NC_012466.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; CapD protein, required for the biosynthesis of type 1 capsular polysaccharide 112731 7678818 SPJ_0126 Streptococcus pneumoniae JJA CapD protein, required for the biosynthesis of type 1 capsular polysaccharide YP_002735240.1 110881 D 488222 CDS YP_002735241.1 225853729 7678480 complement(113037..113669) 1 NC_012466.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; phosphoglycolate phosphatase 113669 7678480 SPJ_0127 Streptococcus pneumoniae JJA phosphoglycolate phosphatase YP_002735241.1 113037 R 488222 CDS YP_002735242.1 225853730 7679823 complement(113691..114563) 1 NC_012466.1 identified by match to protein family HMM PF03313; match to protein family HMM TIGR00718; L-serine dehydratase, iron-sulfur-dependent, alpha subunit 114563 sdaAA 7679823 sdaAA Streptococcus pneumoniae JJA L-serine dehydratase, iron-sulfur-dependent, alpha subunit YP_002735242.1 113691 R 488222 CDS YP_002735243.1 225853731 7680189 complement(114572..115243) 1 NC_012466.1 identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719; L-serine dehydratase, iron-sulfur-dependent, beta subunit 115243 sdaAB 7680189 sdaAB Streptococcus pneumoniae JJA L-serine dehydratase, iron-sulfur-dependent, beta subunit YP_002735243.1 114572 R 488222 CDS YP_002735244.1 225853732 7678462 115485..116072 1 NC_012466.1 identified by match to protein family HMM PF01476; LysM domain protein 116072 7678462 SPJ_0130 Streptococcus pneumoniae JJA LysM domain protein YP_002735244.1 115485 D 488222 CDS YP_002735245.1 225853733 7678864 complement(116124..116444) 1 NC_012466.1 hypothetical protein 116444 7678864 SPJ_0131 Streptococcus pneumoniae JJA hypothetical protein YP_002735245.1 116124 R 488222 CDS YP_002735246.1 225853734 7679974 116928..117143 1 NC_012466.1 identified by match to protein family HMM TIGR01653; bacteriocin, lactococcin 972 family 117143 7679974 SPJ_0132 Streptococcus pneumoniae JJA bacteriocin, lactococcin 972 family YP_002735246.1 116928 D 488222 CDS YP_002735247.1 225853735 7680422 117285..119306 1 NC_012466.1 identified by match to protein family HMM TIGR01654; amino acid ABC transporter permease 119306 7680422 SPJ_0133 Streptococcus pneumoniae JJA amino acid ABC transporter permease YP_002735247.1 117285 D 488222 CDS YP_002735248.1 225853736 7678705 119303..119944 1 NC_012466.1 identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease protein MacB 119944 7678705 SPJ_0134 Streptococcus pneumoniae JJA macrolide export ATP-binding/permease protein MacB YP_002735248.1 119303 D 488222 CDS YP_002735249.1 225853737 7679210 120151..120957 1 NC_012466.1 identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein 120957 7679210 SPJ_0135 Streptococcus pneumoniae JJA amino acid ABC transporter substrate-binding protein YP_002735249.1 120151 D 488222 CDS YP_002735250.1 225853738 7679485 122200..123591 1 NC_012466.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 123591 argH 7679485 argH Streptococcus pneumoniae JJA argininosuccinate lyase YP_002735250.1 122200 D 488222 CDS YP_002735251.1 225853739 7678526 complement(123880..124743) 1 NC_012466.1 identified by match to protein family HMM PF01381; helix-turn-helix domain protein 124743 7678526 SPJ_0139 Streptococcus pneumoniae JJA helix-turn-helix domain protein YP_002735251.1 123880 R 488222 CDS YP_002735252.1 225853740 7679114 125209..127428 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193; lactococcin-G-processing and transport ATP-binding protein LagD 127428 7679114 SPJ_0140 Streptococcus pneumoniae JJA lactococcin-G-processing and transport ATP-binding protein LagD YP_002735252.1 125209 D 488222 CDS YP_002735253.1 225853741 7680318 127421..127888 1 NC_012466.1 hypothetical protein 127888 7680318 SPJ_0141 Streptococcus pneumoniae JJA hypothetical protein YP_002735253.1 127421 D 488222 CDS YP_002735254.1 225853742 7680310 127885..129237 1 NC_012466.1 hypothetical protein 129237 7680310 SPJ_0142 Streptococcus pneumoniae JJA hypothetical protein YP_002735254.1 127885 D 488222 CDS YP_002735255.1 225853743 7678868 129382..129699 1 NC_012466.1 hypothetical protein 129699 7678868 SPJ_0143 Streptococcus pneumoniae JJA hypothetical protein YP_002735255.1 129382 D 488222 CDS YP_002735256.1 225853744 7679390 129708..130607 1 NC_012466.1 hypothetical protein 130607 7679390 SPJ_0144 Streptococcus pneumoniae JJA hypothetical protein YP_002735256.1 129708 D 488222 CDS YP_002735257.1 225853745 7679613 130663..130995 1 NC_012466.1 hypothetical protein 130995 7679613 SPJ_0145 Streptococcus pneumoniae JJA hypothetical protein YP_002735257.1 130663 D 488222 CDS YP_002735258.1 225853746 7679564 130992..131720 1 NC_012466.1 hypothetical protein 131720 7679564 SPJ_0146 Streptococcus pneumoniae JJA hypothetical protein YP_002735258.1 130992 D 488222 CDS YP_002735259.1 225853747 7680066 132855..133358 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 133358 7680066 SPJ_0147 Streptococcus pneumoniae JJA hypothetical protein YP_002735259.1 132855 D 488222 CDS YP_002735260.1 225853748 7680266 136049..136174 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 136174 7680266 SPJ_0150 Streptococcus pneumoniae JJA hypothetical protein YP_002735260.1 136049 D 488222 CDS YP_002735261.1 225853749 7679036 136197..137318 1 NC_012466.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 137318 mnmA 7679036 mnmA Streptococcus pneumoniae JJA tRNA-specific 2-thiouridylase MnmA YP_002735261.1 136197 D 488222 CDS YP_002735262.1 225853750 7679500 137459..137914 1 NC_012466.1 identified by match to protein family HMM PF00293; MutT/nudix family protein 137914 7679500 SPJ_0152 Streptococcus pneumoniae JJA MutT/nudix family protein YP_002735262.1 137459 D 488222 CDS YP_002735263.1 225853751 7680223 137924..139837 1 NC_012466.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 139837 gidA 7680223 gidA Streptococcus pneumoniae JJA tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA YP_002735263.1 137924 D 488222 CDS YP_002735264.1 225853752 7678814 complement(139969..140118) 1 NC_012466.1 chlorohydrolase 140118 7678814 SPJ_0154 Streptococcus pneumoniae JJA chlorohydrolase YP_002735264.1 139969 R 488222 CDS YP_002735265.1 225853753 7678962 complement(140190..141869) 1 NC_012466.1 identified by match to protein family HMM PF00753; match to protein family HMM PF07521; match to protein family HMM TIGR00649; metallo-beta-lactamase superfamily protein 141869 7678962 SPJ_0155 Streptococcus pneumoniae JJA metallo-beta-lactamase superfamily protein YP_002735265.1 140190 R 488222 CDS YP_002735266.1 225853754 7679779 complement(141871..142104) 1 NC_012466.1 identified by match to protein family HMM PF07288; hypothetical protein 142104 7679779 SPJ_0156 Streptococcus pneumoniae JJA hypothetical protein YP_002735266.1 141871 R 488222 CDS YP_002735267.1 225853755 7680465 complement(142922..143074) 1 NC_012466.1 identified by match to protein family HMM TIGR01847; bacteriocin-type signal sequence domain protein 143074 7680465 SPJ_0157 Streptococcus pneumoniae JJA bacteriocin-type signal sequence domain protein YP_002735267.1 142922 R 488222 CDS YP_002735268.1 225853756 7680194 complement(143076..143261) 1 NC_012466.1 hypothetical protein 143261 7680194 SPJ_0158 Streptococcus pneumoniae JJA hypothetical protein YP_002735268.1 143076 R 488222 CDS YP_002735269.1 225853757 7679408 143439..144122 1 NC_012466.1 identified by match to protein family HMM PF00814; glycoprotein endopeptidase 144122 7679408 SPJ_0159 Streptococcus pneumoniae JJA glycoprotein endopeptidase YP_002735269.1 143439 D 488222 CDS YP_002735270.1 225853758 7680132 144119..144556 1 NC_012466.1 identified by match to protein family HMM PF00583; match to protein family HMM TIGR01575; ribosomal-protein-alanine acetyltransferase 144556 rimI 7680132 rimI Streptococcus pneumoniae JJA ribosomal-protein-alanine acetyltransferase YP_002735270.1 144119 D 488222 CDS YP_002735271.1 225853759 7678429 144546..145556 1 NC_012466.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 145556 7678429 SPJ_0161 Streptococcus pneumoniae JJA putative DNA-binding/iron metalloprotein/AP endonuclease YP_002735271.1 144546 D 488222 CDS YP_002735272.1 225853760 7679781 complement(145596..145982) 1 NC_012466.1 transposase 145982 7679781 SPJ_0162 Streptococcus pneumoniae JJA transposase YP_002735272.1 145596 R 488222 CDS YP_002735273.1 225853761 7679416 complement(145973..146950) 1 NC_012466.1 identified by match to protein family HMM PF01610; transposase 146950 7679416 SPJ_0163 Streptococcus pneumoniae JJA transposase YP_002735273.1 145973 R 488222 CDS YP_002735274.1 225853762 7678581 149371..150324 1 NC_012466.1 identified by match to protein family HMM PF00535; glycosyl transferase, family 2 150324 7678581 SPJ_0166 Streptococcus pneumoniae JJA glycosyl transferase, family 2 YP_002735274.1 149371 D 488222 CDS YP_002735275.1 225853763 7679153 150334..151950 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 151950 7679153 SPJ_0167 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002735275.1 150334 D 488222 CDS YP_002735276.1 225853764 7678912 152503..152727 1 NC_012466.1 hypothetical protein 152727 7678912 SPJ_0168 Streptococcus pneumoniae JJA hypothetical protein YP_002735276.1 152503 D 488222 CDS YP_002735277.1 225853765 7678807 152739..153488 1 NC_012466.1 identified by match to protein family HMM PF02585; GlcNAc-PI de-N-acetylase family 153488 7678807 SPJ_0169 Streptococcus pneumoniae JJA GlcNAc-PI de-N-acetylase family YP_002735277.1 152739 D 488222 CDS YP_002735278.1 225853766 7680375 153501..154673 1 NC_012466.1 identified by match to protein family HMM PF00984; match to protein family HMM PF03721; match to protein family HMM TIGR03026; UDP-glucose 6-dehydrogenase 154673 7680375 SPJ_0170 Streptococcus pneumoniae JJA UDP-glucose 6-dehydrogenase YP_002735278.1 153501 D 488222 CDS YP_002735279.1 225853767 7679797 155069..155932 1 NC_012466.1 identified by match to protein family HMM TIGR01716; MutR 155932 7679797 SPJ_0171 Streptococcus pneumoniae JJA MutR YP_002735279.1 155069 D 488222 CDS YP_002735280.1 225853768 7679180 156218..156418 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 156418 7679180 SPJ_0172 Streptococcus pneumoniae JJA hypothetical protein YP_002735280.1 156218 D 488222 CDS YP_002735281.1 225853769 7678533 156485..157150 1 NC_012466.1 identified by match to protein family HMM PF02517; caax amino protease family 157150 7678533 SPJ_0173 Streptococcus pneumoniae JJA caax amino protease family YP_002735281.1 156485 D 488222 CDS YP_002735282.1 225853770 7680108 157222..158448 1 NC_012466.1 transporter, major facilitator family protein 158448 7680108 SPJ_0174 Streptococcus pneumoniae JJA transporter, major facilitator family protein YP_002735282.1 157222 D 488222 CDS YP_002735283.1 225853771 7679431 158901..159557 1 NC_012466.1 identified by match to protein family HMM PF03591; branched-chain amino acid permease 159557 7679431 SPJ_0175 Streptococcus pneumoniae JJA branched-chain amino acid permease YP_002735283.1 158901 D 488222 CDS YP_002735284.1 225853772 7678825 159547..159756 1 NC_012466.1 identified by match to protein family HMM PF05437; transmembrane protein 159756 7678825 SPJ_0176 Streptococcus pneumoniae JJA transmembrane protein YP_002735284.1 159547 D 488222 CDS YP_002735285.1 225853773 7680321 159974..160804 1 NC_012466.1 identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein 160804 7680321 SPJ_0177 Streptococcus pneumoniae JJA amino acid ABC transporter substrate-binding protein YP_002735285.1 159974 D 488222 CDS YP_002735286.1 225853774 7679746 160958..161812 1 NC_012466.1 identified by match to protein family HMM PF03180; lipoprotein 161812 7679746 SPJ_0178 Streptococcus pneumoniae JJA lipoprotein YP_002735286.1 160958 D 488222 CDS YP_002735287.1 225853775 7679579 161912..163285 1 NC_012466.1 identified by match to protein family HMM PF01546; match to protein family HMM PF07687; acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase 163285 7679579 SPJ_0179 Streptococcus pneumoniae JJA acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase YP_002735287.1 161912 D 488222 CDS YP_002735288.1 225853776 7679034 163278..164339 1 NC_012466.1 identified by match to protein family HMM PF00005; methionine import ATP-binding protein MetN 164339 7679034 SPJ_0180 Streptococcus pneumoniae JJA methionine import ATP-binding protein MetN YP_002735288.1 163278 D 488222 CDS YP_002735289.1 225853777 7678607 164341..165033 1 NC_012466.1 identified by match to protein family HMM PF00528; ABC transporter permease 165033 7678607 SPJ_0181 Streptococcus pneumoniae JJA ABC transporter permease YP_002735289.1 164341 D 488222 CDS YP_002735290.1 225853778 7680171 complement(165062..165631) 1 NC_012466.1 identified by match to protein family HMM TIGR02185; membrane-bound protein 165631 7680171 SPJ_0182 Streptococcus pneumoniae JJA membrane-bound protein YP_002735290.1 165062 R 488222 CDS YP_002735291.1 225853779 7680390 165766..166380 1 NC_012466.1 identified by match to protein family HMM PF04854; hypothetical protein 166380 7680390 SPJ_0183 Streptococcus pneumoniae JJA hypothetical protein YP_002735291.1 165766 D 488222 CDS YP_002735292.1 225853780 7679772 166430..168028 1 NC_012466.1 identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF06580; sensor histidine kinase, putative 168028 7679772 SPJ_0184 Streptococcus pneumoniae JJA sensor histidine kinase, putative YP_002735292.1 166430 D 488222 CDS YP_002735293.1 225853781 7679423 168040..169326 1 NC_012466.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00165; response regulator 169326 7679423 SPJ_0185 Streptococcus pneumoniae JJA response regulator YP_002735293.1 168040 D 488222 CDS YP_002735294.1 225853782 7678844 169378..169911 1 NC_012466.1 hypothetical protein 169911 7678844 SPJ_0186 Streptococcus pneumoniae JJA hypothetical protein YP_002735294.1 169378 D 488222 CDS YP_002735295.1 225853783 7680124 169989..170459 1 NC_012466.1 has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; flavoprotein NrdI 170459 7680124 SPJ_0187 Streptococcus pneumoniae JJA flavoprotein NrdI YP_002735295.1 169989 D 488222 CDS YP_002735296.1 225853784 7679535 complement(170752..172014) 1 NC_012466.1 mn2+ and fe2+ transporter of the nramp family 172014 7679535 SPJ_0188 Streptococcus pneumoniae JJA mn2+ and fe2+ transporter of the nramp family YP_002735296.1 170752 R 488222 CDS YP_002735297.1 225853785 7680083 complement(172324..172782) 1 NC_012466.1 hypothetical protein 172782 7680083 SPJ_0189 Streptococcus pneumoniae JJA hypothetical protein YP_002735297.1 172324 R 488222 CDS YP_002735298.1 225853786 7679774 complement(172779..173219) 1 NC_012466.1 identified by match to protein family HMM PF04397; response regulator of the LytR/AlgR family 173219 7679774 SPJ_0190 Streptococcus pneumoniae JJA response regulator of the LytR/AlgR family YP_002735298.1 172779 R 488222 CDS YP_002735299.1 225853787 7679169 173575..175524 1 NC_012466.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 175524 mutL 7679169 mutL Streptococcus pneumoniae JJA DNA mismatch repair protein YP_002735299.1 173575 D 488222 CDS YP_002735300.1 225853788 7679051 complement(175849..176316) 1 NC_012466.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 176316 ribH 7679051 ribH Streptococcus pneumoniae JJA 6,7-dimethyl-8-ribityllumazine synthase YP_002735300.1 175849 R 488222 CDS YP_002735301.1 225853789 7678498 complement(176317..177522) 1 NC_012466.1 identified by match to protein family HMM PF00925; match to protein family HMM PF00926; match to protein family HMM TIGR00505; match to protein family HMM TIGR00506; riboflavin biosynthesis protein ribAB 177522 7678498 SPJ_0193 Streptococcus pneumoniae JJA riboflavin biosynthesis protein ribAB YP_002735301.1 176317 R 488222 CDS YP_002735302.1 225853790 7680258 complement(177542..178177) 1 NC_012466.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 178177 ribE 7680258 ribE Streptococcus pneumoniae JJA riboflavin synthase subunit alpha YP_002735302.1 177542 R 488222 CDS YP_002735303.1 225853791 7679648 complement(178162..179262) 1 NC_012466.1 identified by match to protein family HMM PF00383; match to protein family HMM PF01872; match to protein family HMM TIGR00227; match to protein family HMM TIGR00326; riboflavin biosynthesis protein RibD 179262 ribD 7679648 ribD Streptococcus pneumoniae JJA riboflavin biosynthesis protein RibD YP_002735303.1 178162 R 488222 CDS YP_002735304.1 225853792 7679279 179668..180261 1 NC_012466.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 180261 ruvA 7679279 ruvA Streptococcus pneumoniae JJA Holliday junction DNA helicase RuvA YP_002735304.1 179668 D 488222 CDS YP_002735305.1 225853793 7678697 180271..180834 1 NC_012466.1 identified by match to protein family HMM PF03352; DNA-3-methyladenine glycosylase 1 180834 7678697 SPJ_0197 Streptococcus pneumoniae JJA DNA-3-methyladenine glycosylase 1 YP_002735305.1 180271 D 488222 CDS YP_002735306.1 225853794 7680548 180831..181508 1 NC_012466.1 identified by match to protein family HMM PF02517; caax amino protease family 181508 7680548 SPJ_0198 Streptococcus pneumoniae JJA caax amino protease family YP_002735306.1 180831 D 488222 CDS YP_002735307.1 225853795 7680131 complement(181649..182680) 1 NC_012466.1 identified by match to protein family HMM PF02016; MccC family protein 182680 7680131 SPJ_0199 Streptococcus pneumoniae JJA MccC family protein YP_002735307.1 181649 R 488222 CDS YP_002735308.1 225853796 7679348 complement(182935..183618) 1 NC_012466.1 identified by match to protein family HMM PF06570; hypothetical protein 183618 7679348 SPJ_0200 Streptococcus pneumoniae JJA hypothetical protein YP_002735308.1 182935 R 488222 CDS YP_002735309.1 225853797 7679156 complement(183630..184574) 1 NC_012466.1 identified by match to protein family HMM PF01544; magnesium and cobalt transporter 184574 7679156 SPJ_0201 Streptococcus pneumoniae JJA magnesium and cobalt transporter YP_002735309.1 183630 R 488222 CDS YP_002735310.1 225853798 7679195 184706..187537 1 NC_012466.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 187537 uvrA 7679195 uvrA Streptococcus pneumoniae JJA excinuclease ABC subunit A YP_002735310.1 184706 D 488222 CDS YP_002735311.1 225853799 7679512 187530..188591 1 NC_012466.1 identified by match to protein family HMM PF00557; match to protein family HMM PF01321; Xaa-Pro dipeptidase 188591 7679512 SPJ_0203 Streptococcus pneumoniae JJA Xaa-Pro dipeptidase YP_002735311.1 187530 D 488222 CDS YP_002735312.1 225853800 7678679 188723..189121 1 NC_012466.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 189121 spxA 7678679 spxA Streptococcus pneumoniae JJA transcriptional regulator Spx YP_002735312.1 188723 D 488222 CDS YP_002735313.1 225853801 7678566 189187..189756 1 NC_012466.1 lipoprotein, putative 189756 7678566 SPJ_0205 Streptococcus pneumoniae JJA lipoprotein, putative YP_002735313.1 189187 D 488222 CDS YP_002735314.1 225853802 7679945 189843..190109 1 NC_012466.1 identified by match to protein family HMM PF06135; hypothetical protein 190109 7679945 SPJ_0206 Streptococcus pneumoniae JJA hypothetical protein YP_002735314.1 189843 D 488222 CDS YP_002735315.1 225853803 7680535 190113..190532 1 NC_012466.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 190532 7680535 SPJ_0207 Streptococcus pneumoniae JJA Holliday junction resolvase-like protein YP_002735315.1 190113 D 488222 CDS YP_002735316.1 225853804 7678439 190548..190853 1 NC_012466.1 identified by match to protein family HMM PF06949; hypothetical protein 190853 7678439 SPJ_0208 Streptococcus pneumoniae JJA hypothetical protein YP_002735316.1 190548 D 488222 CDS YP_002735317.1 225853805 7678559 191111..192361 1 NC_012466.1 identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; dihydrofolate:folylpolyglutamate synthetase 192361 7678559 SPJ_0209 Streptococcus pneumoniae JJA dihydrofolate:folylpolyglutamate synthetase YP_002735317.1 191111 D 488222 CDS YP_002735318.1 225853806 7680400 192358..192900 1 NC_012466.1 hypothetical protein 192900 7680400 SPJ_0210 Streptococcus pneumoniae JJA hypothetical protein YP_002735318.1 192358 D 488222 CDS YP_002735319.1 225853807 7679794 193046..194578 1 NC_012466.1 identified by match to protein family HMM PF00614; cardiolipin synthase 194578 7679794 SPJ_0211 Streptococcus pneumoniae JJA cardiolipin synthase YP_002735319.1 193046 D 488222 CDS YP_002735320.1 225853808 7679369 194836..196374 1 NC_012466.1 competence-induced protein Ccs4 196374 7679369 SPJ_0212 Streptococcus pneumoniae JJA competence-induced protein Ccs4 YP_002735320.1 194836 D 488222 CDS YP_002735321.1 225853809 7678797 196494..198701 1 NC_012466.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 198701 nrdD 7678797 nrdD Streptococcus pneumoniae JJA anaerobic ribonucleoside triphosphate reductase YP_002735321.1 196494 D 488222 CDS YP_002735322.1 225853810 7679551 198713..198853 1 NC_012466.1 hypothetical protein 198853 7679551 SPJ_0214 Streptococcus pneumoniae JJA hypothetical protein YP_002735322.1 198713 D 488222 CDS YP_002735323.1 225853811 7678942 198897..199403 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 199403 7678942 SPJ_0215 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002735323.1 198897 D 488222 CDS YP_002735324.1 225853812 7678610 199396..199986 1 NC_012466.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR02491; anaerobic ribonucleoside-triphosphate reductase activating protein 199986 nrdG 7678610 nrdG Streptococcus pneumoniae JJA anaerobic ribonucleoside-triphosphate reductase activating protein YP_002735324.1 199396 D 488222 CDS YP_002735325.1 225853813 7680401 199994..200611 1 NC_012466.1 identified by match to protein family HMM PF00485; phosphoribulokinase / Uridine kinase family 200611 7680401 SPJ_0217 Streptococcus pneumoniae JJA phosphoribulokinase / Uridine kinase family YP_002735325.1 199994 D 488222 CDS YP_002735326.1 225853814 7679803 200877..201185 1 NC_012466.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 201185 rpsJ 7679803 rpsJ Streptococcus pneumoniae JJA 30S ribosomal protein S10 YP_002735326.1 200877 D 488222 CDS YP_002735327.1 225853815 7679587 201402..202028 1 NC_012466.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 202028 rplC 7679587 rplC Streptococcus pneumoniae JJA 50S ribosomal protein L3 YP_002735327.1 201402 D 488222 CDS YP_002735328.1 225853816 7679202 202053..202676 1 NC_012466.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 202676 rplD 7679202 rplD Streptococcus pneumoniae JJA 50S ribosomal protein L4 YP_002735328.1 202053 D 488222 CDS YP_002735329.1 225853817 7679525 202676..202972 1 NC_012466.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 202972 rplW 7679525 rplW Streptococcus pneumoniae JJA 50S ribosomal protein L23 YP_002735329.1 202676 D 488222 CDS YP_002735330.1 225853818 7680387 202990..203823 1 NC_012466.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 203823 rplB 7680387 rplB Streptococcus pneumoniae JJA 50S ribosomal protein L2 YP_002735330.1 202990 D 488222 CDS YP_002735331.1 225853819 7678706 203927..204208 1 NC_012466.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 204208 rpsS 7678706 rpsS Streptococcus pneumoniae JJA 30S ribosomal protein S19 YP_002735331.1 203927 D 488222 CDS YP_002735332.1 225853820 7679418 204220..204564 1 NC_012466.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 204564 rplV 7679418 rplV Streptococcus pneumoniae JJA 50S ribosomal protein L22 YP_002735332.1 204220 D 488222 CDS YP_002735333.1 225853821 7679909 204577..205230 1 NC_012466.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 205230 rpsC 7679909 rpsC Streptococcus pneumoniae JJA 30S ribosomal protein S3 YP_002735333.1 204577 D 488222 CDS YP_002735334.1 225853822 7678460 205234..205647 1 NC_012466.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 205647 rplP 7678460 rplP Streptococcus pneumoniae JJA 50S ribosomal protein L16 YP_002735334.1 205234 D 488222 CDS YP_002735335.1 225853823 7678936 205657..205863 1 NC_012466.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 205863 rpmC 7678936 rpmC Streptococcus pneumoniae JJA 50S ribosomal protein L29 YP_002735335.1 205657 D 488222 CDS YP_002735336.1 225853824 7678464 205888..206148 1 NC_012466.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 206148 rpsQ 7678464 rpsQ Streptococcus pneumoniae JJA 30S ribosomal protein S17 YP_002735336.1 205888 D 488222 CDS YP_002735337.1 225853825 7679144 206174..206542 1 NC_012466.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 206542 rplN 7679144 rplN Streptococcus pneumoniae JJA 50S ribosomal protein L14 YP_002735337.1 206174 D 488222 CDS YP_002735338.1 225853826 7679641 206620..206925 1 NC_012466.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 206925 rplX 7679641 rplX Streptococcus pneumoniae JJA 50S ribosomal protein L24 YP_002735338.1 206620 D 488222 CDS YP_002735339.1 225853827 7680158 206949..207491 1 NC_012466.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 207491 rplE 7680158 rplE Streptococcus pneumoniae JJA 50S ribosomal protein L5 YP_002735339.1 206949 D 488222 CDS YP_002735340.1 225853828 7679046 207509..207778 1 NC_012466.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 207778 rpsN 7679046 rpsN Streptococcus pneumoniae JJA 30S ribosomal protein S14 YP_002735340.1 207509 D 488222 CDS YP_002735341.1 225853829 7679670 208063..208461 1 NC_012466.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 208461 rpsH 7679670 rpsH Streptococcus pneumoniae JJA 30S ribosomal protein S8 YP_002735341.1 208063 D 488222 CDS YP_002735342.1 225853830 7680283 208653..209189 1 NC_012466.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 209189 rplF 7680283 rplF Streptococcus pneumoniae JJA 50S ribosomal protein L6 YP_002735342.1 208653 D 488222 CDS YP_002735343.1 225853831 7679240 209273..209629 1 NC_012466.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 209629 rplR 7679240 rplR Streptococcus pneumoniae JJA 50S ribosomal protein L18 YP_002735343.1 209273 D 488222 CDS YP_002735344.1 225853832 7678674 209647..210141 1 NC_012466.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 210141 rpsE 7678674 rpsE Streptococcus pneumoniae JJA 30S ribosomal protein S5 YP_002735344.1 209647 D 488222 CDS YP_002735345.1 225853833 7679336 210155..210337 1 NC_012466.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 210337 rpmD 7679336 rpmD Streptococcus pneumoniae JJA 50S ribosomal protein L30 YP_002735345.1 210155 D 488222 CDS YP_002735346.1 225853834 7679965 210482..210922 1 NC_012466.1 late assembly protein; 50S ribosomal protein L15 210922 rplO 7679965 rplO Streptococcus pneumoniae JJA 50S ribosomal protein L15 YP_002735346.1 210482 D 488222 CDS YP_002735347.1 225853835 7680531 210935..212245 1 NC_012466.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 212245 secY 7680531 secY Streptococcus pneumoniae JJA preprotein translocase subunit SecY YP_002735347.1 210935 D 488222 CDS YP_002735348.1 225853836 7678935 212396..213034 1 NC_012466.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 213034 adk 7678935 adk Streptococcus pneumoniae JJA adenylate kinase YP_002735348.1 212396 D 488222 CDS YP_002735349.1 225853837 7679470 213151..213369 1 NC_012466.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 213369 infA 7679470 infA Streptococcus pneumoniae JJA translation initiation factor IF-1 YP_002735349.1 213151 D 488222 CDS YP_002735350.1 225853838 7680263 213394..213510 1 NC_012466.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 213510 rpmJ 7680263 rpmJ Streptococcus pneumoniae JJA 50S ribosomal protein L36 YP_002735350.1 213394 D 488222 CDS YP_002735351.1 225853839 7678960 213528..213893 1 NC_012466.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 213893 rpsM 7678960 rpsM Streptococcus pneumoniae JJA 30S ribosomal protein S13 YP_002735351.1 213528 D 488222 CDS YP_002735352.1 225853840 7679567 213911..214294 1 NC_012466.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 214294 rpsK 7679567 rpsK Streptococcus pneumoniae JJA 30S ribosomal protein S11 YP_002735352.1 213911 D 488222 CDS YP_002735353.1 225853841 7680265 214337..215272 1 NC_012466.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 215272 rpoA 7680265 rpoA Streptococcus pneumoniae JJA DNA-directed RNA polymerase subunit alpha YP_002735353.1 214337 D 488222 CDS YP_002735354.1 225853842 7679640 215284..215670 1 NC_012466.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 215670 rplQ 7679640 rplQ Streptococcus pneumoniae JJA 50S ribosomal protein L17 YP_002735354.1 215284 D 488222 CDS YP_002735355.1 225853843 7679318 215935..216201 1 NC_012466.1 ACT domain-containing protein; hypothetical protein 216201 7679318 SPJ_0247 Streptococcus pneumoniae JJA hypothetical protein YP_002735355.1 215935 D 488222 CDS YP_002735356.1 225853844 7678718 216211..217548 1 NC_012466.1 identified by match to protein family HMM PF05167; hypothetical protein 217548 7678718 SPJ_0248 Streptococcus pneumoniae JJA hypothetical protein YP_002735356.1 216211 D 488222 CDS YP_002735357.1 225853845 7680539 217735..218484 1 NC_012466.1 identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein 218484 7680539 SPJ_0249 Streptococcus pneumoniae JJA phosphoglycerate mutase family protein YP_002735357.1 217735 D 488222 CDS YP_002735358.1 225853846 7680230 complement(222654..222851) 1 NC_012466.1 identified by match to protein family HMM PF00165; AraC family transcriptional regulator 222851 7680230 SPJ_0256 Streptococcus pneumoniae JJA AraC family transcriptional regulator YP_002735358.1 222654 R 488222 CDS YP_002735359.1 225853847 7678749 complement(222926..223702) 1 NC_012466.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494; pyruvate formate-lyase 3 223702 7678749 SPJ_0257 Streptococcus pneumoniae JJA pyruvate formate-lyase 3 YP_002735359.1 222926 R 488222 CDS YP_002735360.1 225853848 7680186 223824..224570 1 NC_012466.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; putative HTH-type transcriptional regulator YciT 224570 7680186 SPJ_0258 Streptococcus pneumoniae JJA putative HTH-type transcriptional regulator YciT YP_002735360.1 223824 D 488222 CDS YP_002735361.1 225853849 7679992 224583..225563 1 NC_012466.1 identified by match to protein family HMM PF04198; transcriptional regulator 225563 7679992 SPJ_0259 Streptococcus pneumoniae JJA transcriptional regulator YP_002735361.1 224583 D 488222 CDS YP_002735362.1 225853850 7679565 225758..226078 1 NC_012466.1 identified by match to protein family HMM PF02255; phosphotransferase system sugar-specific eiia component 226078 7679565 SPJ_0260 Streptococcus pneumoniae JJA phosphotransferase system sugar-specific eiia component YP_002735362.1 225758 D 488222 CDS YP_002735363.1 225853851 7679533 226124..226432 1 NC_012466.1 identified by match to protein family HMM PF02302; phosphotransferase system sugar-specific eiib component 226432 7679533 SPJ_0261 Streptococcus pneumoniae JJA phosphotransferase system sugar-specific eiib component YP_002735363.1 226124 D 488222 CDS YP_002735364.1 225853852 7680053 226449..227747 1 NC_012466.1 identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) 227747 7680053 SPJ_0262 Streptococcus pneumoniae JJA lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) YP_002735364.1 226449 D 488222 CDS YP_002735365.1 225853853 7680389 227898..230336 1 NC_012466.1 identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01774; pyruvate formate-lyase 230336 7680389 SPJ_0263 Streptococcus pneumoniae JJA pyruvate formate-lyase YP_002735365.1 227898 D 488222 CDS YP_002735366.1 225853854 7679207 230355..231023 1 NC_012466.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 231023 7679207 SPJ_0264 Streptococcus pneumoniae JJA fructose-6-phosphate aldolase YP_002735366.1 230355 D 488222 CDS YP_002735367.1 225853855 7679789 231041..232129 1 NC_012466.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 232129 gldA 7679789 gldA Streptococcus pneumoniae JJA glycerol dehydrogenase YP_002735367.1 231041 D 488222 CDS YP_002735368.1 225853856 7680372 232584..235085 1 NC_012466.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 235085 leuS 7680372 leuS Streptococcus pneumoniae JJA leucyl-tRNA synthetase YP_002735368.1 232584 D 488222 CDS YP_002735369.1 225853857 7678831 235279..235974 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 235974 7678831 SPJ_0267 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002735369.1 235279 D 488222 CDS YP_002735370.1 225853858 7679025 235986..236402 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 236402 7679025 SPJ_0268 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002735370.1 235986 D 488222 CDS YP_002735371.1 225853859 7679148 237443..238441 1 NC_012466.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 238441 ruvB 7679148 ruvB Streptococcus pneumoniae JJA Holliday junction DNA helicase RuvB YP_002735371.1 237443 D 488222 CDS YP_002735372.1 225853860 7680080 238422..238994 1 NC_012466.1 identified by match to protein family HMM PF06042; hypothetical protein 238994 7680080 SPJ_0270 Streptococcus pneumoniae JJA hypothetical protein YP_002735372.1 238422 D 488222 CDS YP_002735373.1 225853861 7679910 239225..239983 1 NC_012466.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase 239983 uppS 7679910 uppS Streptococcus pneumoniae JJA UDP pyrophosphate synthase YP_002735373.1 239225 D 488222 CDS YP_002735374.1 225853862 7679295 239992..240795 1 NC_012466.1 identified by match to protein family HMM PF01148; phosphatidate cytidylyltransferase 240795 cdsA 7679295 cdsA Streptococcus pneumoniae JJA phosphatidate cytidylyltransferase YP_002735374.1 239992 D 488222 CDS YP_002735375.1 225853863 7679326 240817..242076 1 NC_012466.1 identified by match to protein family HMM PF02163; match to protein family HMM TIGR00054; RIP metalloprotease RseP 242076 rseP 7679326 rseP Streptococcus pneumoniae JJA RIP metalloprotease RseP YP_002735375.1 240817 D 488222 CDS YP_002735376.1 225853864 7678699 242089..243942 1 NC_012466.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 243942 proS 7678699 proS Streptococcus pneumoniae JJA prolyl-tRNA synthetase YP_002735376.1 242089 D 488222 CDS YP_002735377.1 225853865 7679762 244042..245421 1 NC_012466.1 identified by match to protein family HMM PF00232; 6-phospho-beta-glucosidase 245421 7679762 SPJ_0275 Streptococcus pneumoniae JJA 6-phospho-beta-glucosidase YP_002735377.1 244042 D 488222 CDS YP_002735378.1 225853866 7679067 245613..247421 1 NC_012466.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 247421 glmS 7679067 glmS Streptococcus pneumoniae JJA glucosamine--fructose-6-phosphate aminotransferase YP_002735378.1 245613 D 488222 CDS YP_002735379.1 225853867 7680112 247540..248589 1 NC_012466.1 identified by match to protein family HMM PF00296; oxidoreductase 248589 7680112 SPJ_0277 Streptococcus pneumoniae JJA oxidoreductase YP_002735379.1 247540 D 488222 CDS YP_002735380.1 225853868 7679582 complement(248689..252486) 1 NC_012466.1 identified by match to protein family HMM PF00128; match to protein family HMM PF00746; match to protein family HMM PF02922; match to protein family HMM PF03714; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; match to protein family HMM TIGR02102; pullulanase, extracellular 252486 7679582 SPJ_0278 Streptococcus pneumoniae JJA pullulanase, extracellular YP_002735380.1 248689 R 488222 CDS YP_002735381.1 225853869 7679105 252902..253315 1 NC_012466.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 253315 rpsL 7679105 rpsL Streptococcus pneumoniae JJA 30S ribosomal protein S12 YP_002735381.1 252902 D 488222 CDS YP_002735382.1 225853870 7679149 253335..253805 1 NC_012466.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 253805 rpsG 7679149 rpsG Streptococcus pneumoniae JJA 30S ribosomal protein S7 YP_002735382.1 253335 D 488222 CDS YP_002735383.1 225853871 7680294 254229..256310 1 NC_012466.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 256310 fusA 7680294 fusA Streptococcus pneumoniae JJA elongation factor G YP_002735383.1 254229 D 488222 CDS YP_002735384.1 225853872 7678740 256414..260805 1 NC_012466.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 260805 polC 7678740 polC Streptococcus pneumoniae JJA DNA polymerase III PolC YP_002735384.1 256414 D 488222 CDS YP_002735385.1 225853873 7679396 260907..261170 1 NC_012466.1 identified by match to protein family HMM PF04221; match to protein family HMM TIGR02384; addiction module antitoxin, RelB/DinJ family 261170 7679396 SPJ_0283 Streptococcus pneumoniae JJA addiction module antitoxin, RelB/DinJ family YP_002735385.1 260907 D 488222 CDS YP_002735386.1 225853874 7679990 261163..261441 1 NC_012466.1 identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; DNA damage inducible protein 261441 7679990 SPJ_0284 Streptococcus pneumoniae JJA DNA damage inducible protein YP_002735386.1 261163 D 488222 CDS YP_002735387.1 225853875 7678866 261462..261614 1 NC_012466.1 hypothetical protein 261614 7678866 SPJ_0285 Streptococcus pneumoniae JJA hypothetical protein YP_002735387.1 261462 D 488222 CDS YP_002735388.1 225853876 7679413 261636..262877 1 NC_012466.1 identified by match to protein family HMM PF02073; aminopeptidase PepS 262877 7679413 SPJ_0286 Streptococcus pneumoniae JJA aminopeptidase PepS YP_002735388.1 261636 D 488222 CDS YP_002735389.1 225853877 7679095 262887..263117 1 NC_012466.1 identified by match to protein family HMM PF04226; integral membrane protein 263117 7679095 SPJ_0287 Streptococcus pneumoniae JJA integral membrane protein YP_002735389.1 262887 D 488222 CDS YP_002735390.1 225853878 7679513 263430..264152 1 NC_012466.1 identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; RNA pseudouridine synthase family protein 264152 7679513 SPJ_0288 Streptococcus pneumoniae JJA RNA pseudouridine synthase family protein YP_002735390.1 263430 D 488222 CDS YP_002735391.1 225853879 7678589 264369..265703 1 NC_012466.1 identified by match to protein family HMM PF03051; aminopeptidase C (Bleomycin hydrolase) 265703 7678589 SPJ_0289 Streptococcus pneumoniae JJA aminopeptidase C (Bleomycin hydrolase) YP_002735391.1 264369 D 488222 CDS YP_002735392.1 225853880 7679397 complement(265759..266670) 1 NC_012466.1 identified by match to protein family HMM PF03613; match to protein family HMM TIGR00828; PTS system, mannose/fructose/sorbose family, IID component 266670 7679397 SPJ_0290 Streptococcus pneumoniae JJA PTS system, mannose/fructose/sorbose family, IID component YP_002735392.1 265759 R 488222 CDS YP_002735393.1 225853881 7679071 complement(266694..267497) 1 NC_012466.1 identified by match to protein family HMM PF03609; PTS system sorbose-specific IIc component 267497 7679071 SPJ_0291 Streptococcus pneumoniae JJA PTS system sorbose-specific IIc component YP_002735393.1 266694 R 488222 CDS YP_002735394.1 225853882 7678625 complement(267525..268514) 1 NC_012466.1 identified by match to protein family HMM PF03610; match to protein family HMM PF03830; mannose-specific phosphotransferase system component iiab 268514 7678625 SPJ_0292 Streptococcus pneumoniae JJA mannose-specific phosphotransferase system component iiab YP_002735394.1 267525 R 488222 CDS YP_002735395.1 225853883 7679592 complement(268747..269766) 1 NC_012466.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 269766 7679592 SPJ_0293 Streptococcus pneumoniae JJA alcohol dehydrogenase YP_002735395.1 268747 R 488222 CDS YP_002735396.1 225853884 7679084 complement(269875..270021) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 270021 7679084 SPJ_0294 Streptococcus pneumoniae JJA hypothetical protein YP_002735396.1 269875 R 488222 CDS YP_002735397.1 225853885 7678633 complement(270118..270930) 1 NC_012466.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 270930 7678633 SPJ_0295 Streptococcus pneumoniae JJA Cof family protein YP_002735397.1 270118 R 488222 CDS YP_002735398.1 225853886 7680222 271120..272538 1 NC_012466.1 identified by match to protein family HMM PF00860; xanthine/uracil permease family protein 272538 7680222 SPJ_0296 Streptococcus pneumoniae JJA xanthine/uracil permease family protein YP_002735398.1 271120 D 488222 CDS YP_002735399.1 225853887 7679259 272591..273298 1 NC_012466.1 identified by match to protein family HMM PF02517; caax amino protease family protein 273298 7679259 SPJ_0297 Streptococcus pneumoniae JJA caax amino protease family protein YP_002735399.1 272591 D 488222 CDS YP_002735400.1 225853888 7678755 273498..274475 1 NC_012466.1 identified by match to protein family HMM PF00809; match to protein family HMM TIGR01496; dihydropteroate synthase 274475 folP 7678755 folP Streptococcus pneumoniae JJA dihydropteroate synthase YP_002735400.1 273498 D 488222 CDS YP_002735401.1 225853889 7680459 274477..275799 1 NC_012466.1 identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; dihydrofolate synthetase 275799 7680459 SPJ_0299 Streptococcus pneumoniae JJA dihydrofolate synthetase YP_002735401.1 274477 D 488222 CDS YP_002735402.1 225853890 7679634 275780..276334 1 NC_012466.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 276334 folE 7679634 folE Streptococcus pneumoniae JJA GTP cyclohydrolase I YP_002735402.1 275780 D 488222 CDS YP_002735403.1 225853891 7679026 276377..277189 1 NC_012466.1 identified by match to protein family HMM PF01288; match to protein family HMM PF02152; match to protein family HMM TIGR00525; match to protein family HMM TIGR00526; match to protein family HMM TIGR01498; bifunctional folate synthesis protein 277189 7679026 SPJ_0301 Streptococcus pneumoniae JJA bifunctional folate synthesis protein YP_002735403.1 276377 D 488222 CDS YP_002735404.1 225853892 7678415 complement(277234..277551) 1 NC_012466.1 hypothetical protein 277551 7678415 SPJ_0302 Streptococcus pneumoniae JJA hypothetical protein YP_002735404.1 277234 R 488222 CDS YP_002735405.1 225853893 7680345 277991..278944 1 NC_012466.1 identified by match to protein family HMM PF00665; transposase 278944 7680345 SPJ_0303 Streptococcus pneumoniae JJA transposase YP_002735405.1 277991 D 488222 CDS YP_002735406.1 225853894 7679625 279153..279599 1 NC_012466.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 279599 rplM 7679625 rplM Streptococcus pneumoniae JJA 50S ribosomal protein L13 YP_002735406.1 279153 D 488222 CDS YP_002735407.1 225853895 7679403 279618..280010 1 NC_012466.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 280010 rpsI 7679403 rpsI Streptococcus pneumoniae JJA 30S ribosomal protein S9 YP_002735407.1 279618 D 488222 CDS YP_002735408.1 225853896 7678676 complement(280272..280694) 1 NC_012466.1 identified by match to protein family HMM PF00589; integrase/recombinase, phage integrase family 280694 7678676 SPJ_0306 Streptococcus pneumoniae JJA integrase/recombinase, phage integrase family YP_002735408.1 280272 R 488222 CDS YP_002735409.1 225853897 7679536 280841..281017 1 NC_012466.1 hypothetical protein 281017 7679536 SPJ_0307 Streptococcus pneumoniae JJA hypothetical protein YP_002735409.1 280841 D 488222 CDS YP_002735410.1 225853898 7679937 281419..283632 1 NC_012466.1 identified by match to protein family HMM PF01055; glycosyl hydrolase, family 31 283632 7679937 SPJ_0308 Streptococcus pneumoniae JJA glycosyl hydrolase, family 31 YP_002735410.1 281419 D 488222 CDS YP_002735411.1 225853899 7678560 complement(283854..284330) 1 NC_012466.1 identified by match to protein family HMM PF00255; peroxiredoxin Hyr1 (hydrogen peroxide resistanceprotein 1) (oxidant receptor peroxidase 1) (glutathione peroxidase 3)(phospholipid hydroperoxide glutathione peroxidase 3) (phgpx3) 284330 7678560 SPJ_0309 Streptococcus pneumoniae JJA peroxiredoxin Hyr1 (hydrogen peroxide resistanceprotein 1) (oxidant receptor peroxidase 1) (glutathione peroxidase 3)(phospholipid hydroperoxide glutathione peroxidase 3) (phgpx3) YP_002735411.1 283854 R 488222 CDS YP_002735412.1 225853900 7680339 284553..287756 1 NC_012466.1 identified by match to protein family HMM PF00746; match to protein family HMM PF02018; match to protein family HMM PF02278; match to protein family HMM PF02884; match to protein family HMM PF08124; match to protein family HMM TIGR01167; hyaluronate lyase 287756 7680339 SPJ_0310 Streptococcus pneumoniae JJA hyaluronate lyase YP_002735412.1 284553 D 488222 CDS YP_002735413.1 225853901 7679253 288171..288524 1 NC_012466.1 transposase 288524 7679253 SPJ_0311 Streptococcus pneumoniae JJA transposase YP_002735413.1 288171 D 488222 CDS YP_002735414.1 225853902 7679699 complement(288900..289529) 1 NC_012466.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 289529 7679699 SPJ_0312 Streptococcus pneumoniae JJA keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_002735414.1 288900 R 488222 CDS YP_002735415.1 225853903 7680215 complement(289539..290540) 1 NC_012466.1 identified by match to protein family HMM PF00294; 2-keto-3-deoxygluconate kinase 290540 7680215 SPJ_0313 Streptococcus pneumoniae JJA 2-keto-3-deoxygluconate kinase YP_002735415.1 289539 R 488222 CDS YP_002735416.1 225853904 7678496 complement(290571..291212) 1 NC_012466.1 identified by match to protein family HMM PF02502; hypothetical protein 291212 7678496 SPJ_0314 Streptococcus pneumoniae JJA hypothetical protein YP_002735416.1 290571 R 488222 CDS YP_002735417.1 225853905 7679555 complement(291231..292046) 1 NC_012466.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 292046 7679555 SPJ_0315 Streptococcus pneumoniae JJA gluconate 5-dehydrogenase YP_002735417.1 291231 R 488222 CDS YP_002735418.1 225853906 7680003 292317..292751 1 NC_012466.1 identified by match to protein family HMM PF03610; phosphotransferase system sugar-specific EII component 292751 7680003 SPJ_0316 Streptococcus pneumoniae JJA phosphotransferase system sugar-specific EII component YP_002735418.1 292317 D 488222 CDS YP_002735419.1 225853907 7680454 292763..293953 1 NC_012466.1 identified by match to protein family HMM PF07470; unsaturated glucuronyl hydrolase (UGL) (Glycuronidase)(Unsaturated uronic acid hydrolase) (Glycosaminoglycan hydrolase) 293953 7680454 SPJ_0317 Streptococcus pneumoniae JJA unsaturated glucuronyl hydrolase (UGL) (Glycuronidase)(Unsaturated uronic acid hydrolase) (Glycosaminoglycan hydrolase) YP_002735419.1 292763 D 488222 CDS YP_002735420.1 225853908 7678741 293964..294455 1 NC_012466.1 identified by match to protein family HMM PF03830; N-acetylgalactosamine-specific phosphotransferase enzyme iib component2 (pts system n-acetylgalactosamine-specific eiibcomponent 2) (eiib-aga') 294455 7678741 SPJ_0318 Streptococcus pneumoniae JJA N-acetylgalactosamine-specific phosphotransferase enzyme iib component2 (pts system n-acetylgalactosamine-specific eiibcomponent 2) (eiib-aga') YP_002735420.1 293964 D 488222 CDS YP_002735421.1 225853909 7679862 294470..295249 1 NC_012466.1 identified by match to protein family HMM PF03609; phosphotransferase system sugar-specific EII component 295249 7679862 SPJ_0319 Streptococcus pneumoniae JJA phosphotransferase system sugar-specific EII component YP_002735421.1 294470 D 488222 CDS YP_002735422.1 225853910 7679995 295236..296054 1 NC_012466.1 identified by match to protein family HMM PF03613; PTS system, IID component 296054 7679995 SPJ_0320 Streptococcus pneumoniae JJA PTS system, IID component YP_002735422.1 295236 D 488222 CDS YP_002735423.1 225853911 7679986 296081..296347 1 NC_012466.1 preprotein translocase, YajC subunit 296347 7679986 SPJ_0321 Streptococcus pneumoniae JJA preprotein translocase, YajC subunit YP_002735423.1 296081 D 488222 CDS YP_002735424.1 225853912 7680440 296369..298270 1 NC_012466.1 identified by match to protein family HMM PF07940; oligohyaluronate lyase 298270 7680440 SPJ_0322 Streptococcus pneumoniae JJA oligohyaluronate lyase YP_002735424.1 296369 D 488222 CDS YP_002735425.1 225853913 7678424 298330..299331 1 NC_012466.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sugar binding transcriptional regulator RegR 299331 7678424 SPJ_0323 Streptococcus pneumoniae JJA sugar binding transcriptional regulator RegR YP_002735425.1 298330 D 488222 CDS YP_002735426.1 225853914 7679199 complement(299441..299776) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 299776 7679199 SPJ_0324 Streptococcus pneumoniae JJA hypothetical protein YP_002735426.1 299441 R 488222 CDS YP_002735427.1 225853915 7680231 complement(299787..300029) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 300029 7680231 SPJ_0325 Streptococcus pneumoniae JJA hypothetical protein YP_002735427.1 299787 R 488222 CDS YP_002735428.1 225853916 7679332 complement(300045..300239) 1 NC_012466.1 identified by match to protein family HMM PF01381; hypothetical protein 300239 7679332 SPJ_0326 Streptococcus pneumoniae JJA hypothetical protein YP_002735428.1 300045 R 488222 CDS YP_002735429.1 225853917 7679972 300405..301355 1 NC_012466.1 identified by match to protein family HMM PF01795; match to protein family HMM TIGR00006; S-adenosyl-methyltransferase MraW 301355 mraW 7679972 mraW Streptococcus pneumoniae JJA S-adenosyl-methyltransferase MraW YP_002735429.1 300405 D 488222 CDS YP_002735430.1 225853918 7680455 301367..301684 1 NC_012466.1 identified by match to protein family HMM TIGR02209; cell division protein FtsL 301684 ftsL 7680455 ftsL Streptococcus pneumoniae JJA cell division protein FtsL YP_002735430.1 301367 D 488222 CDS YP_002735431.1 225853919 7680445 301688..303940 1 NC_012466.1 identified by match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM PF03793; penicillin binding protein 2x 303940 7680445 SPJ_0329 Streptococcus pneumoniae JJA penicillin binding protein 2x YP_002735431.1 301688 D 488222 CDS YP_002735432.1 225853920 7680307 303942..304922 1 NC_012466.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 304922 mraY 7680307 mraY Streptococcus pneumoniae JJA phospho-N-acetylmuramoyl-pentapeptide- transferase YP_002735432.1 303942 D 488222 CDS YP_002735433.1 225853921 7680135 305486..307591 1 NC_012466.1 identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; ATP-dependent Clp protease ATP-binding subunit ClpL 307591 7680135 SPJ_0331 Streptococcus pneumoniae JJA ATP-dependent Clp protease ATP-binding subunit ClpL YP_002735433.1 305486 D 488222 CDS YP_002735434.1 225853922 7678909 complement(307887..308369) 1 NC_012466.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 308369 luxS 7678909 luxS Streptococcus pneumoniae JJA S-ribosylhomocysteinase YP_002735434.1 307887 R 488222 CDS YP_002735435.1 225853923 7679175 complement(308464..309948) 1 NC_012466.1 identified by match to protein family HMM PF08903; hypothetical protein 309948 7679175 SPJ_0333 Streptococcus pneumoniae JJA hypothetical protein YP_002735435.1 308464 R 488222 CDS YP_002735436.1 225853924 7679684 310101..311708 1 NC_012466.1 identified by match to protein family HMM PF00128; trehalose-6-phosphate hydrolase (Alpha,alpha-phosphotrehalase) 311708 7679684 SPJ_0334 Streptococcus pneumoniae JJA trehalose-6-phosphate hydrolase (Alpha,alpha-phosphotrehalase) YP_002735436.1 310101 D 488222 CDS YP_002735437.1 225853925 7680291 312774..314219 1 NC_012466.1 identified by match to protein family HMM PF02916; match to protein family HMM PF03816; match to protein family HMM TIGR00350; Cps23fA 314219 7680291 SPJ_0335 Streptococcus pneumoniae JJA Cps23fA YP_002735437.1 312774 D 488222 CDS YP_002735438.1 225853926 7679252 314221..314952 1 NC_012466.1 identified by match to protein family HMM PF02811; tyrosine-protein phosphatase CpsB 314952 7679252 SPJ_0336 Streptococcus pneumoniae JJA tyrosine-protein phosphatase CpsB YP_002735438.1 314221 D 488222 CDS YP_002735439.1 225853927 7679905 314961..315653 1 NC_012466.1 identified by match to protein family HMM PF02706; match to protein family HMM TIGR01006; capsular polysaccharide biosynthesis protein Wzd 315653 7679905 SPJ_0337 Streptococcus pneumoniae JJA capsular polysaccharide biosynthesis protein Wzd YP_002735439.1 314961 D 488222 CDS YP_002735440.1 225853928 7680509 315663..316346 1 NC_012466.1 identified by match to protein family HMM TIGR01007; tyrosine-protein kinase CpsD 316346 7680509 SPJ_0338 Streptococcus pneumoniae JJA tyrosine-protein kinase CpsD YP_002735440.1 315663 D 488222 CDS YP_002735441.1 225853929 7679913 316362..317729 1 NC_012466.1 identified by match to protein family HMM PF02397; galactosyl transferase CpsE 317729 7679913 SPJ_0339 Streptococcus pneumoniae JJA galactosyl transferase CpsE YP_002735441.1 316362 D 488222 CDS YP_002735442.1 225853930 7679236 317733..318182 1 NC_012466.1 identified by match to protein family HMM PF08660; exopolysaccharide biosynthesis protein, glycosyltransferase 318182 7679236 SPJ_0340 Streptococcus pneumoniae JJA exopolysaccharide biosynthesis protein, glycosyltransferase YP_002735442.1 317733 D 488222 CDS YP_002735443.1 225853931 7679829 318182..318685 1 NC_012466.1 identified by match to protein family HMM PF04101; ss-1,4-galactosyltransferase 318685 7679829 SPJ_0341 Streptococcus pneumoniae JJA ss-1,4-galactosyltransferase YP_002735443.1 318182 D 488222 CDS YP_002735444.1 225853932 7680342 318675..319847 1 NC_012466.1 oligosaccharide repeat unit polymerase Wzy 319847 7680342 SPJ_0342 Streptococcus pneumoniae JJA oligosaccharide repeat unit polymerase Wzy YP_002735444.1 318675 D 488222 CDS YP_002735445.1 225853933 7678641 319844..320863 1 NC_012466.1 identified by match to protein family HMM PF00535; ss-1,3-N-acetylglucosaminyltransferase 320863 7678641 SPJ_0343 Streptococcus pneumoniae JJA ss-1,3-N-acetylglucosaminyltransferase YP_002735445.1 319844 D 488222 CDS YP_002735446.1 225853934 7679384 320878..321834 1 NC_012466.1 identified by match to protein family HMM PF00535; ss-1,4-galactosyltransferase 321834 7679384 SPJ_0344 Streptococcus pneumoniae JJA ss-1,4-galactosyltransferase YP_002735446.1 320878 D 488222 CDS YP_002735447.1 225853935 7679873 321922..322770 1 NC_012466.1 identified by match to protein family HMM PF05704; capsular polysaccharide synthesis protein 322770 7679873 SPJ_0345 Streptococcus pneumoniae JJA capsular polysaccharide synthesis protein YP_002735447.1 321922 D 488222 CDS YP_002735448.1 225853936 7678469 322763..324226 1 NC_012466.1 identified by match to protein family HMM PF01943; match to protein family HMM PF03023; flippase Wzx 324226 7678469 SPJ_0346 Streptococcus pneumoniae JJA flippase Wzx YP_002735448.1 322763 D 488222 CDS YP_002735449.1 225853937 7679281 325235..331246 1 NC_012466.1 identified by match to protein family HMM PF00746; match to protein family HMM PF05738; match to protein family HMM TIGR01167; collagen-binding protein A 331246 7679281 SPJ_0350 Streptococcus pneumoniae JJA collagen-binding protein A YP_002735449.1 325235 D 488222 CDS YP_002735450.1 225853938 7680544 complement(331200..331331) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 331331 7680544 SPJ_0349 Streptococcus pneumoniae JJA hypothetical protein YP_002735450.1 331200 R 488222 CDS YP_002735451.1 225853939 7678662 complement(331401..332162) 1 NC_012466.1 identified by match to protein family HMM PF01610; transposase 332162 7678662 SPJ_0351 Streptococcus pneumoniae JJA transposase YP_002735451.1 331401 R 488222 CDS YP_002735452.1 225853940 7680060 complement(332159..332677) 1 NC_012466.1 transposase 332677 7680060 SPJ_0352 Streptococcus pneumoniae JJA transposase YP_002735452.1 332159 R 488222 CDS YP_002735453.1 225853941 7679561 332916..334898 1 NC_012466.1 identified by match to protein family HMM PF00496; oligopeptide binding protein 334898 7679561 SPJ_0353 Streptococcus pneumoniae JJA oligopeptide binding protein YP_002735453.1 332916 D 488222 CDS YP_002735454.1 225853942 7680246 335199..340502 1 NC_012466.1 identified by match to protein family HMM PF00754; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; endo-alpha-N-acetylgalactosaminidase 340502 7680246 SPJ_0354 Streptococcus pneumoniae JJA endo-alpha-N-acetylgalactosaminidase YP_002735454.1 335199 D 488222 CDS YP_002735455.1 225853943 7679589 complement(340669..342828) 1 NC_012466.1 identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 1A 342828 7679589 SPJ_0355 Streptococcus pneumoniae JJA penicillin-binding protein 1A YP_002735455.1 340669 R 488222 CDS YP_002735456.1 225853944 7679283 complement(342825..343421) 1 NC_012466.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease 343421 recU 7679283 recU Streptococcus pneumoniae JJA Holliday junction-specific endonuclease YP_002735456.1 342825 R 488222 CDS YP_002735457.1 225853945 7678651 343487..344014 1 NC_012466.1 identified by match to protein family HMM PF06908; hypothetical protein 344014 7678651 SPJ_0357 Streptococcus pneumoniae JJA hypothetical protein YP_002735457.1 343487 D 488222 CDS YP_002735458.1 225853946 7680498 344084..344413 1 NC_012466.1 identified by match to protein family HMM PF05103; cell division initiation protein 344413 7680498 SPJ_0358 Streptococcus pneumoniae JJA cell division initiation protein YP_002735458.1 344084 D 488222 CDS YP_002735459.1 225853947 7679742 344899..346056 1 NC_012466.1 identified by match to protein family HMM PF01170; methyltransferase 346056 7679742 SPJ_0359 Streptococcus pneumoniae JJA methyltransferase YP_002735459.1 344899 D 488222 CDS YP_002735460.1 225853948 7680423 346069..347463 1 NC_012466.1 hypothetical protein 347463 7680423 SPJ_0360 Streptococcus pneumoniae JJA hypothetical protein YP_002735460.1 346069 D 488222 CDS YP_002735461.1 225853949 7679780 347539..348963 1 NC_012466.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 348963 gnd 7679780 gnd Streptococcus pneumoniae JJA 6-phosphogluconate dehydrogenase YP_002735461.1 347539 D 488222 CDS YP_002735462.1 225853950 7679432 348975..349664 1 NC_012466.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator 349664 7679432 SPJ_0362 Streptococcus pneumoniae JJA DNA-binding response regulator YP_002735462.1 348975 D 488222 CDS YP_002735463.1 225853951 7678812 349762..350727 1 NC_012466.1 identified by match to protein family HMM PF01473; choline-binding protein F 350727 7678812 SPJ_0363 Streptococcus pneumoniae JJA choline-binding protein F YP_002735463.1 349762 D 488222 CDS YP_002735464.1 225853952 7679461 350746..351744 1 NC_012466.1 identified by match to protein family HMM PF01473; choline binding protein J 351744 7679461 SPJ_0364 Streptococcus pneumoniae JJA choline binding protein J YP_002735464.1 350746 D 488222 CDS YP_002735465.1 225853953 7678842 complement(351862..353094) 1 NC_012466.1 identified by match to protein family HMM PF07690; transporter, major facilitator family protein 353094 7678842 SPJ_0365 Streptococcus pneumoniae JJA transporter, major facilitator family protein YP_002735465.1 351862 R 488222 CDS YP_002735466.1 225853954 7680161 complement(353137..353961) 1 NC_012466.1 identified by match to protein family HMM PF05147; hypothetical protein 353961 7680161 SPJ_0366 Streptococcus pneumoniae JJA hypothetical protein YP_002735466.1 353137 R 488222 CDS YP_002735467.1 225853955 7679702 354830..354952 1 NC_012466.1 identified by match to protein family HMM PF01473; choline-binding protein F 354952 7679702 SPJ_0367 Streptococcus pneumoniae JJA choline-binding protein F YP_002735467.1 354830 D 488222 CDS YP_002735468.1 225853956 7679190 355074..355952 1 NC_012466.1 identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR00549; mevalonate kinase 355952 mvk 7679190 mvk Streptococcus pneumoniae JJA mevalonate kinase YP_002735468.1 355074 D 488222 CDS YP_002735469.1 225853957 7678701 355934..356887 1 NC_012466.1 identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR01240; diphosphomevalonate decarboxylase 356887 mvaD 7678701 mvaD Streptococcus pneumoniae JJA diphosphomevalonate decarboxylase YP_002735469.1 355934 D 488222 CDS YP_002735470.1 225853958 7680525 356874..357881 1 NC_012466.1 identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR01220; phosphomevalonate kinase 357881 7680525 SPJ_0370 Streptococcus pneumoniae JJA phosphomevalonate kinase YP_002735470.1 356874 D 488222 CDS YP_002735471.1 225853959 7678987 357865..358875 1 NC_012466.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 358875 fni 7678987 fni Streptococcus pneumoniae JJA isopentenyl pyrophosphate isomerase YP_002735471.1 357865 D 488222 CDS YP_002735472.1 225853960 7679313 358952..359650 1 NC_012466.1 hypothetical protein 359650 7679313 SPJ_0372 Streptococcus pneumoniae JJA hypothetical protein YP_002735472.1 358952 D 488222 CDS YP_002735473.1 225853961 7679938 359647..360642 1 NC_012466.1 identified by match to protein family HMM PF02518; match to protein family HMM PF07730; histidine kinase 360642 7679938 SPJ_0373 Streptococcus pneumoniae JJA histidine kinase YP_002735473.1 359647 D 488222 CDS YP_002735474.1 225853962 7678632 360656..361288 1 NC_012466.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00196; match to protein family HMM PF08281; response regulator 361288 7678632 SPJ_0374 Streptococcus pneumoniae JJA response regulator YP_002735474.1 360656 D 488222 CDS YP_002735475.1 225853963 7679245 361502..361756 1 NC_012466.1 DNA alkylation repair enzyme 361756 7679245 SPJ_0375 Streptococcus pneumoniae JJA DNA alkylation repair enzyme YP_002735475.1 361502 D 488222 CDS YP_002735476.1 225853964 7679607 361871..362047 1 NC_012466.1 DNA alkylation repair enzyme, truncation 362047 7679607 SPJ_0376 Streptococcus pneumoniae JJA DNA alkylation repair enzyme, truncation YP_002735476.1 361871 D 488222 CDS YP_002735477.1 225853965 7680176 362197..362436 1 NC_012466.1 hypothetical protein 362436 7680176 SPJ_0377 Streptococcus pneumoniae JJA hypothetical protein YP_002735477.1 362197 D 488222 CDS YP_002735478.1 225853966 7678899 362517..363338 1 NC_012466.1 identified by match to protein family HMM PF00089; match to protein family HMM PF01473; choline binding protein G 363338 7678899 SPJ_0378 Streptococcus pneumoniae JJA choline binding protein G YP_002735478.1 362517 D 488222 CDS YP_002735479.1 225853967 7679209 363357..364379 1 NC_012466.1 identified by match to protein family HMM PF01473; choline binding protein F 364379 7679209 SPJ_0379 Streptococcus pneumoniae JJA choline binding protein F YP_002735479.1 363357 D 488222 CDS YP_002735480.1 225853968 7679773 complement(364507..364995) 1 NC_012466.1 identified by match to protein family HMM PF00665; integrase core domain, putative 364995 7679773 SPJ_0380 Streptococcus pneumoniae JJA integrase core domain, putative YP_002735480.1 364507 R 488222 CDS YP_002735481.1 225853969 7679696 complement(365338..365499) 1 NC_012466.1 hypothetical protein 365499 7679696 SPJ_0381 Streptococcus pneumoniae JJA hypothetical protein YP_002735481.1 365338 R 488222 CDS YP_002735482.1 225853970 7678834 complement(365635..365847) 1 NC_012466.1 transposase 365847 7678834 SPJ_0382 Streptococcus pneumoniae JJA transposase YP_002735482.1 365635 R 488222 CDS YP_002735483.1 225853971 7679299 366056..367825 1 NC_012466.1 identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00851; pts system mannitol-specific eiicb component (eiicb-mtl) (eii-mtl) 367825 7679299 SPJ_0383 Streptococcus pneumoniae JJA pts system mannitol-specific eiicb component (eiicb-mtl) (eii-mtl) YP_002735483.1 366056 D 488222 CDS YP_002735484.1 225853972 7679531 367849..369804 1 NC_012466.1 identified by match to protein family HMM PF08279; putative transcriptional regulator MtlR 369804 7679531 SPJ_0384 Streptococcus pneumoniae JJA putative transcriptional regulator MtlR YP_002735484.1 367849 D 488222 CDS YP_002735485.1 225853973 7680547 369806..370243 1 NC_012466.1 identified by match to protein family HMM PF00359; mannitol-specific phosphotransferase enzyme iia component (pts system mannitol-specific eiia component) (eiia-mtl) (eiii-mtl) 370243 7680547 SPJ_0385 Streptococcus pneumoniae JJA mannitol-specific phosphotransferase enzyme iia component (pts system mannitol-specific eiia component) (eiia-mtl) (eiii-mtl) YP_002735485.1 369806 D 488222 CDS YP_002735486.1 225853974 7678393 370305..371441 1 NC_012466.1 identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol-1-phosphate 5-dehydrogenase 371441 7678393 SPJ_0386 Streptococcus pneumoniae JJA mannitol-1-phosphate 5-dehydrogenase YP_002735486.1 370305 D 488222 CDS YP_002735487.1 225853975 7679058 371830..371934 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 371934 7679058 SPJ_0387 Streptococcus pneumoniae JJA hypothetical protein YP_002735487.1 371830 D 488222 CDS YP_002735488.1 225853976 7679756 372247..373530 1 NC_012466.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 373530 tig 7679756 tig Streptococcus pneumoniae JJA trigger factor YP_002735488.1 372247 D 488222 CDS YP_002735489.1 225853977 7679128 complement(373578..375944) 1 NC_012466.1 identified by match to protein family HMM TIGR01448; helicase, RecD/TraA family 375944 7679128 SPJ_0389 Streptococcus pneumoniae JJA helicase, RecD/TraA family YP_002735489.1 373578 R 488222 CDS YP_002735490.1 225853978 7680062 complement(376178..376792) 1 NC_012466.1 identified by match to protein family HMM PF00717; match to protein family HMM TIGR02227; signal peptidase I 376792 lepB 7680062 lepB Streptococcus pneumoniae JJA signal peptidase I YP_002735490.1 376178 R 488222 CDS YP_002735491.1 225853979 7680104 complement(376796..377677) 1 NC_012466.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII 377677 rnhC 7680104 rnhC Streptococcus pneumoniae JJA ribonuclease HIII YP_002735491.1 376796 R 488222 CDS YP_002735492.1 225853980 7678659 377764..378066 1 NC_012466.1 hypothetical protein 378066 7678659 SPJ_0392 Streptococcus pneumoniae JJA hypothetical protein YP_002735492.1 377764 D 488222 CDS YP_002735493.1 225853981 7679132 378063..378611 1 NC_012466.1 identified by match to protein family HMM PF02674; CvpA family protein 378611 cvpA 7679132 cvpA Streptococcus pneumoniae JJA CvpA family protein YP_002735493.1 378063 D 488222 CDS YP_002735494.1 225853982 7679902 378715..381051 1 NC_012466.1 identified by match to protein family HMM PF00488; match to protein family HMM PF01713; match to protein family HMM TIGR01069; MutS2 family protein 381051 7679902 SPJ_0394 Streptococcus pneumoniae JJA MutS2 family protein YP_002735494.1 378715 D 488222 CDS YP_002735495.1 225853983 7679886 381394..382716 1 NC_012466.1 identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835; D-alanine glycine permease 382716 7679886 SPJ_0395 Streptococcus pneumoniae JJA D-alanine glycine permease YP_002735495.1 381394 D 488222 CDS YP_002735496.1 225853984 7680349 382934..383482 1 NC_012466.1 identified by match to protein family HMM PF02627; match to protein family HMM TIGR00778; macrophage infectivity potentiator protein 383482 7680349 SPJ_0396 Streptococcus pneumoniae JJA macrophage infectivity potentiator protein YP_002735496.1 382934 D 488222 CDS YP_002735497.1 225853985 7679061 383592..384491 1 NC_012466.1 identified by match to protein family HMM PF03595; exfoliative toxin A 384491 7679061 SPJ_0397 Streptococcus pneumoniae JJA exfoliative toxin A YP_002735497.1 383592 D 488222 CDS YP_002735498.1 225853986 7679381 complement(384516..385790) 1 NC_012466.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 385790 serS 7679381 serS Streptococcus pneumoniae JJA seryl-tRNA synthetase YP_002735498.1 384516 R 488222 CDS YP_002735499.1 225853987 7679526 complement(386004..386375) 1 NC_012466.1 identified by match to protein family HMM PF06115; ManO 386375 7679526 SPJ_0399 Streptococcus pneumoniae JJA ManO YP_002735499.1 386004 R 488222 CDS YP_002735500.1 225853988 7678799 complement(386378..387742) 1 NC_012466.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase 387742 7678799 SPJ_0400 Streptococcus pneumoniae JJA aspartate kinase YP_002735500.1 386378 R 488222 CDS YP_002735501.1 225853989 7679947 388111..388896 1 NC_012466.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 388896 7679947 SPJ_0401 Streptococcus pneumoniae JJA enoyl-CoA hydratase YP_002735501.1 388111 D 488222 CDS YP_002735502.1 225853990 7680323 388990..389424 1 NC_012466.1 identified by match to protein family HMM PF01047; match to protein family HMM PF03965; transcriptional regulator 389424 7680323 SPJ_0402 Streptococcus pneumoniae JJA transcriptional regulator YP_002735502.1 388990 D 488222 CDS YP_002735503.1 225853991 7678731 389424..390398 1 NC_012466.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 390398 7678731 SPJ_0403 Streptococcus pneumoniae JJA 3-oxoacyl-(acyl carrier protein) synthase III YP_002735503.1 389424 D 488222 CDS YP_002735504.1 225853992 7678524 390458..390682 1 NC_012466.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 390682 acpP 7678524 acpP Streptococcus pneumoniae JJA acyl carrier protein YP_002735504.1 390458 D 488222 CDS YP_002735505.1 225853993 7678568 390801..391775 1 NC_012466.1 identified by match to protein family HMM PF03060; match to protein family HMM TIGR03151; enoyl-ACP reductase II 391775 7678568 SPJ_0405 Streptococcus pneumoniae JJA enoyl-ACP reductase II YP_002735505.1 390801 D 488222 CDS YP_002735506.1 225853994 7679878 391768..392688 1 NC_012466.1 identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128; malonyl CoA-acyl carrier protein transacylase 392688 fabD 7679878 fabD Streptococcus pneumoniae JJA malonyl CoA-acyl carrier protein transacylase YP_002735506.1 391768 D 488222 CDS YP_002735507.1 225853995 7680334 392722..393453 1 NC_012466.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 393453 fabG 7680334 fabG Streptococcus pneumoniae JJA 3-ketoacyl-ACP reductase YP_002735507.1 392722 D 488222 CDS YP_002735508.1 225853996 7678896 393475..394710 1 NC_012466.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 394710 fabF 7678896 fabF Streptococcus pneumoniae JJA 3-oxoacyl-(acyl carrier protein) synthase II YP_002735508.1 393475 D 488222 CDS YP_002735509.1 225853997 7678900 394713..395198 1 NC_012466.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 395198 accB 7678900 accB Streptococcus pneumoniae JJA acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_002735509.1 394713 D 488222 CDS YP_002735510.1 225853998 7679982 395195..395617 1 NC_012466.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 395617 fabZ 7679982 fabZ Streptococcus pneumoniae JJA (3R)-hydroxymyristoyl-ACP dehydratase YP_002735510.1 395195 D 488222 CDS YP_002735511.1 225853999 7678558 395629..396996 1 NC_012466.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 396996 accC 7678558 accC Streptococcus pneumoniae JJA acetyl-CoA carboxylase biotin carboxylase subunit YP_002735511.1 395629 D 488222 CDS YP_002735512.1 225854000 7680133 397033..397899 1 NC_012466.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 397899 accD 7680133 accD Streptococcus pneumoniae JJA acetyl-CoA carboxylase subunit beta YP_002735512.1 397033 D 488222 CDS YP_002735513.1 225854001 7679788 397896..398663 1 NC_012466.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha 398663 accA 7679788 accA Streptococcus pneumoniae JJA acetyl-CoA carboxylase subunit alpha YP_002735513.1 397896 D 488222 CDS YP_002735514.1 225854002 7680405 398822..399007 1 NC_012466.1 hypothetical protein 399007 7680405 SPJ_0414 Streptococcus pneumoniae JJA hypothetical protein YP_002735514.1 398822 D 488222 CDS YP_002735515.1 225854003 7678537 399348..399476 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 399476 7678537 SPJ_0415 Streptococcus pneumoniae JJA hypothetical protein YP_002735515.1 399348 D 488222 CDS YP_002735516.1 225854004 7678690 complement(399627..399764) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 399764 7678690 SPJ_0416 Streptococcus pneumoniae JJA hypothetical protein YP_002735516.1 399627 R 488222 CDS YP_002735517.1 225854005 7678820 complement(399774..400196) 1 NC_012466.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 400196 nusB 7678820 nusB Streptococcus pneumoniae JJA transcription antitermination protein NusB YP_002735517.1 399774 R 488222 CDS YP_002735518.1 225854006 7680428 complement(400189..400578) 1 NC_012466.1 identified by match to protein family HMM PF03780; general stress protein, Gls24 family 400578 7680428 SPJ_0418 Streptococcus pneumoniae JJA general stress protein, Gls24 family YP_002735518.1 400189 R 488222 CDS YP_002735519.1 225854007 7678966 complement(400600..401160) 1 NC_012466.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 401160 efp 7678966 efp Streptococcus pneumoniae JJA elongation factor P YP_002735519.1 400600 R 488222 CDS YP_002735520.1 225854008 7679692 complement(401289..402731) 1 NC_012466.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 402731 gatB 7679692 gatB Streptococcus pneumoniae JJA aspartyl/glutamyl-tRNA amidotransferase subunit B YP_002735520.1 401289 R 488222 CDS YP_002735521.1 225854009 7680514 complement(402731..404197) 1 NC_012466.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 404197 gatA 7680514 gatA Streptococcus pneumoniae JJA aspartyl/glutamyl-tRNA amidotransferase subunit A YP_002735521.1 402731 R 488222 CDS YP_002735522.1 225854010 7678675 complement(404197..404499) 1 NC_012466.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 404499 gatC 7678675 gatC Streptococcus pneumoniae JJA aspartyl/glutamyl-tRNA amidotransferase subunit C YP_002735522.1 404197 R 488222 CDS YP_002735523.1 225854011 7678442 404712..406256 1 NC_012466.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 406256 prfC 7678442 prfC Streptococcus pneumoniae JJA peptide chain release factor 3 YP_002735523.1 404712 D 488222 CDS YP_002735524.1 225854012 7679053 406525..407010 1 NC_012466.1 identified by match to protein family HMM PF01501; glycosyl transferase, family 8 407010 7679053 SPJ_0424 Streptococcus pneumoniae JJA glycosyl transferase, family 8 YP_002735524.1 406525 D 488222 CDS YP_002735525.1 225854013 7679651 407126..407314 1 NC_012466.1 required for 70S ribosome assembly; 50S ribosomal protein L28 407314 rpmB 7679651 rpmB Streptococcus pneumoniae JJA 50S ribosomal protein L28 YP_002735525.1 407126 D 488222 CDS YP_002735526.1 225854014 7680256 407471..407836 1 NC_012466.1 identified by match to protein family HMM PF03780; alkaline shock protein 407836 7680256 SPJ_0426 Streptococcus pneumoniae JJA alkaline shock protein YP_002735526.1 407471 D 488222 CDS YP_002735527.1 225854015 7678886 407839..409506 1 NC_012466.1 identified by match to protein family HMM PF02734; dihydroxyacetone kinase family protein 409506 7678886 SPJ_0427 Streptococcus pneumoniae JJA dihydroxyacetone kinase family protein YP_002735527.1 407839 D 488222 CDS YP_002735528.1 225854016 7679385 409706..411406 1 NC_012466.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit 411406 ilvB 7679385 ilvB Streptococcus pneumoniae JJA acetolactate synthase catalytic subunit YP_002735528.1 409706 D 488222 CDS YP_002735529.1 225854017 7679073 411399..411875 1 NC_012466.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 411875 ilvH 7679073 ilvH Streptococcus pneumoniae JJA acetolactate synthase 3 regulatory subunit YP_002735529.1 411399 D 488222 CDS YP_002735530.1 225854018 7679802 411941..412963 1 NC_012466.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 412963 ilvC 7679802 ilvC Streptococcus pneumoniae JJA ketol-acid reductoisomerase YP_002735530.1 411941 D 488222 CDS YP_002735531.1 225854019 7679192 413166..413306 1 NC_012466.1 hypothetical protein 413306 7679192 SPJ_0431 Streptococcus pneumoniae JJA hypothetical protein YP_002735531.1 413166 D 488222 CDS YP_002735532.1 225854020 7678564 413544..413900 1 NC_012466.1 hypothetical protein 413900 7678564 SPJ_0432 Streptococcus pneumoniae JJA hypothetical protein YP_002735532.1 413544 D 488222 CDS YP_002735533.1 225854021 7680140 413950..415200 1 NC_012466.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 415200 ilvA 7680140 ilvA Streptococcus pneumoniae JJA threonine dehydratase YP_002735533.1 413950 D 488222 CDS YP_002735534.1 225854022 7678816 415342..415530 1 NC_012466.1 hypothetical protein 415530 7678816 SPJ_0434 Streptococcus pneumoniae JJA hypothetical protein YP_002735534.1 415342 D 488222 CDS YP_002735535.1 225854023 7679460 416071..416286 1 NC_012466.1 hypothetical protein 416286 7679460 SPJ_0435 Streptococcus pneumoniae JJA hypothetical protein YP_002735535.1 416071 D 488222 CDS YP_002735536.1 225854024 7678878 complement(416395..417135) 1 NC_012466.1 identified by match to protein family HMM PF00005; glutamate/aspartate ABC transporter, ATP-binding protein 417135 gltL 7678878 gltL Streptococcus pneumoniae JJA glutamate/aspartate ABC transporter, ATP-binding protein YP_002735536.1 416395 R 488222 CDS YP_002735537.1 225854025 7678491 complement(417135..418700) 1 NC_012466.1 identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease/substrate-binding protein 418700 7678491 SPJ_0437 Streptococcus pneumoniae JJA amino acid ABC transporter permease/substrate-binding protein YP_002735537.1 417135 R 488222 CDS YP_002735538.1 225854026 7680435 418838..420727 1 NC_012466.1 hypothetical protein 420727 7680435 SPJ_0439 Streptococcus pneumoniae JJA hypothetical protein YP_002735538.1 418838 D 488222 CDS YP_002735539.1 225854027 7678669 complement(420724..420894) 1 NC_012466.1 hypothetical protein 420894 7678669 SPJ_0438 Streptococcus pneumoniae JJA hypothetical protein YP_002735539.1 420724 R 488222 CDS YP_002735540.1 225854028 7679857 complement(420926..421897) 1 NC_012466.1 identified by match to protein family HMM PF02371; transposase 421897 7679857 SPJ_0440 Streptococcus pneumoniae JJA transposase YP_002735540.1 420926 R 488222 CDS YP_002735541.1 225854029 7679286 421984..422121 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 422121 7679286 SPJ_0441 Streptococcus pneumoniae JJA hypothetical protein YP_002735541.1 421984 D 488222 CDS YP_002735542.1 225854030 7679044 422152..422997 1 NC_012466.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 422997 7679044 SPJ_0442 Streptococcus pneumoniae JJA UDP pyrophosphate phosphatase YP_002735542.1 422152 D 488222 CDS YP_002735543.1 225854031 7679667 complement(423144..424205) 1 NC_012466.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 424205 7679667 SPJ_0443 Streptococcus pneumoniae JJA DNA polymerase IV YP_002735543.1 423144 R 488222 CDS YP_002735544.1 225854032 7680499 424599..426923 1 NC_012466.1 identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255; formate acetyltransferase 426923 pflB 7680499 pflB Streptococcus pneumoniae JJA formate acetyltransferase YP_002735544.1 424599 D 488222 CDS YP_002735545.1 225854033 7678388 complement(427290..427508) 1 NC_012466.1 hypothetical protein 427508 7678388 SPJ_0445 Streptococcus pneumoniae JJA hypothetical protein YP_002735545.1 427290 R 488222 CDS YP_002735546.1 225854034 7679426 complement(427835..428119) 1 NC_012466.1 hypothetical protein 428119 7679426 SPJ_0446 Streptococcus pneumoniae JJA hypothetical protein YP_002735546.1 427835 R 488222 CDS YP_002735547.1 225854035 7679883 complement(428731..428901) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 428901 7679883 SPJ_0447 Streptococcus pneumoniae JJA hypothetical protein YP_002735547.1 428731 R 488222 CDS YP_002735548.1 225854036 7680329 complement(430043..431482) 1 NC_012466.1 identified by match to protein family HMM PF02386; potassium uptake protein, Trk family 431482 7680329 SPJ_0450 Streptococcus pneumoniae JJA potassium uptake protein, Trk family YP_002735548.1 430043 R 488222 CDS YP_002735549.1 225854037 7679530 complement(431486..432835) 1 NC_012466.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 432835 trkA 7679530 trkA Streptococcus pneumoniae JJA potassium transporter peripheral membrane component YP_002735549.1 431486 R 488222 CDS YP_002735550.1 225854038 7678995 433023..433871 1 NC_012466.1 identified by match to protein family HMM PF01887; hypothetical protein 433871 7678995 SPJ_0452 Streptococcus pneumoniae JJA hypothetical protein YP_002735550.1 433023 D 488222 CDS YP_002735551.1 225854039 7679380 433886..434434 1 NC_012466.1 identified by match to protein family HMM PF07155; hypothetical protein 434434 7679380 SPJ_0453 Streptococcus pneumoniae JJA hypothetical protein YP_002735551.1 433886 D 488222 CDS YP_002735552.1 225854040 7680532 434441..434653 1 NC_012466.1 hypothetical protein 434653 7680532 SPJ_0454 Streptococcus pneumoniae JJA hypothetical protein YP_002735552.1 434441 D 488222 CDS YP_002735553.1 225854041 7679801 434755..436437 1 NC_012466.1 identified by match to protein family HMM PF00005; putative ABC transporter ATP-binding protein 436437 7679801 SPJ_0455 Streptococcus pneumoniae JJA putative ABC transporter ATP-binding protein YP_002735553.1 434755 D 488222 CDS YP_002735554.1 225854042 7679157 436422..437252 1 NC_012466.1 identified by match to protein family HMM PF02361; cobalt transport family protein 437252 7679157 SPJ_0456 Streptococcus pneumoniae JJA cobalt transport family protein YP_002735554.1 436422 D 488222 CDS YP_002735555.1 225854043 7678532 437445..437948 1 NC_012466.1 identified by match to protein family HMM PF00588; CspR 437948 cspR 7678532 cspR Streptococcus pneumoniae JJA CspR YP_002735555.1 437445 D 488222 CDS YP_002735556.1 225854044 7678541 438401..438964 1 NC_012466.1 hypothetical protein 438964 7678541 SPJ_0458 Streptococcus pneumoniae JJA hypothetical protein YP_002735556.1 438401 D 488222 CDS YP_002735557.1 225854045 7680395 438978..439604 1 NC_012466.1 identified by match to protein family HMM PF01569; PAP2 family protein 439604 7680395 SPJ_0459 Streptococcus pneumoniae JJA PAP2 family protein YP_002735557.1 438978 D 488222 CDS YP_002735558.1 225854046 7680205 439632..440021 1 NC_012466.1 hypothetical protein 440021 7680205 SPJ_0460 Streptococcus pneumoniae JJA hypothetical protein YP_002735558.1 439632 D 488222 CDS YP_002735559.1 225854047 7679583 440026..440475 1 NC_012466.1 hypothetical protein 440475 7679583 SPJ_0461 Streptococcus pneumoniae JJA hypothetical protein YP_002735559.1 440026 D 488222 CDS YP_002735560.1 225854048 7679443 440603..441190 1 NC_012466.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 441190 rpoE 7679443 rpoE Streptococcus pneumoniae JJA DNA-directed RNA polymerase subunit delta YP_002735560.1 440603 D 488222 CDS YP_002735561.1 225854049 7678815 complement(441280..441405) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 441405 7678815 SPJ_0463 Streptococcus pneumoniae JJA hypothetical protein YP_002735561.1 441280 R 488222 CDS YP_002735562.1 225854050 7678835 441580..443187 1 NC_012466.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 443187 pyrG 7678835 pyrG Streptococcus pneumoniae JJA CTP synthetase YP_002735562.1 441580 D 488222 CDS YP_002735563.1 225854051 7679808 445741..450579 1 NC_012466.1 identified by match to protein family HMM PF00746; match to protein family HMM PF00754; match to protein family HMM PF03644; match to protein family HMM PF07501; match to protein family HMM PF07523; match to protein family HMM PF07554; match to protein family HMM TIGR01167; endo-beta-N-acetylglucosaminidase D 450579 7679808 SPJ_0467 Streptococcus pneumoniae JJA endo-beta-N-acetylglucosaminidase D YP_002735563.1 445741 D 488222 CDS YP_002735564.1 225854052 7678497 450669..451865 1 NC_012466.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 451865 pgk 7678497 pgk Streptococcus pneumoniae JJA phosphoglycerate kinase YP_002735564.1 450669 D 488222 CDS YP_002735565.1 225854053 7680188 452001..452528 1 NC_012466.1 hypothetical protein 452528 7680188 SPJ_0469 Streptococcus pneumoniae JJA hypothetical protein YP_002735565.1 452001 D 488222 CDS YP_002735566.1 225854054 7679678 452605..452961 1 NC_012466.1 identified by match to protein family HMM PF00376; HTH-type transcriptional regulator GlnR 452961 7679678 SPJ_0470 Streptococcus pneumoniae JJA HTH-type transcriptional regulator GlnR YP_002735566.1 452605 D 488222 CDS YP_002735567.1 225854055 7679297 452998..454344 1 NC_012466.1 identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; glutamine synthetase, type I 454344 glnA 7679297 glnA Streptococcus pneumoniae JJA glutamine synthetase, type I YP_002735567.1 452998 D 488222 CDS YP_002735568.1 225854056 7678452 complement(454440..454559) 1 NC_012466.1 hypothetical protein 454559 7678452 SPJ_0472 Streptococcus pneumoniae JJA hypothetical protein YP_002735568.1 454440 R 488222 CDS YP_002735569.1 225854057 7680289 454817..454954 1 NC_012466.1 hypothetical protein 454954 7680289 SPJ_0473 Streptococcus pneumoniae JJA hypothetical protein YP_002735569.1 454817 D 488222 CDS YP_002735570.1 225854058 7680470 455422..456402 1 NC_012466.1 identified by match to protein family HMM PF01420; type I restriction enzyme 456402 7680470 SPJ_0474 Streptococcus pneumoniae JJA type I restriction enzyme YP_002735570.1 455422 D 488222 CDS YP_002735571.1 225854059 7679054 complement(456969..457766) 1 NC_012466.1 identified by match to protein family HMM PF00589; integrase/recombinase, phage integrase family 457766 7679054 SPJ_0475 Streptococcus pneumoniae JJA integrase/recombinase, phage integrase family YP_002735571.1 456969 R 488222 CDS YP_002735572.1 225854060 7679248 complement(457823..459391) 1 NC_012466.1 identified by match to protein family HMM PF01420; type I site-specific deoxyribonuclease chain S 459391 7679248 SPJ_0476 Streptococcus pneumoniae JJA type I site-specific deoxyribonuclease chain S YP_002735572.1 457823 R 488222 CDS YP_002735573.1 225854061 7678901 complement(459391..460854) 1 NC_012466.1 identified by match to protein family HMM PF02384; type I restriction enzyme 460854 7678901 SPJ_0477 Streptococcus pneumoniae JJA type I restriction enzyme YP_002735573.1 459391 R 488222 CDS YP_002735574.1 225854062 7678977 complement(460867..463200) 1 NC_012466.1 identified by match to protein family HMM PF00270; match to protein family HMM PF04313; match to protein family HMM PF04851; match to protein family HMM PF08463; type I restriction-modification system, R subunit 463200 7678977 SPJ_0478 Streptococcus pneumoniae JJA type I restriction-modification system, R subunit YP_002735574.1 460867 R 488222 CDS YP_002735575.1 225854063 7678635 463579..463773 1 NC_012466.1 hypothetical protein 463773 7678635 SPJ_0479 Streptococcus pneumoniae JJA hypothetical protein YP_002735575.1 463579 D 488222 CDS YP_002735576.1 225854064 7679104 463808..464317 1 NC_012466.1 hypothetical protein 464317 7679104 SPJ_0480 Streptococcus pneumoniae JJA hypothetical protein YP_002735576.1 463808 D 488222 CDS YP_002735577.1 225854065 7678654 464481..465515 1 NC_012466.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 465515 hrcA 7678654 hrcA Streptococcus pneumoniae JJA heat-inducible transcription repressor YP_002735577.1 464481 D 488222 CDS YP_002735578.1 225854066 7680218 465542..466066 1 NC_012466.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 466066 grpE 7680218 grpE Streptococcus pneumoniae JJA heat shock protein GrpE YP_002735578.1 465542 D 488222 CDS YP_002735579.1 225854067 7679494 466546..468369 1 NC_012466.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 468369 dnaK 7679494 dnaK Streptococcus pneumoniae JJA molecular chaperone DnaK YP_002735579.1 466546 D 488222 CDS YP_002735580.1 225854068 7679493 469129..470265 1 NC_012466.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 470265 dnaJ 7679493 dnaJ Streptococcus pneumoniae JJA chaperone protein DnaJ YP_002735580.1 469129 D 488222 CDS YP_002735581.1 225854069 7678887 complement(470577..470906) 1 NC_012466.1 hypothetical protein 470906 7678887 SPJ_0485 Streptococcus pneumoniae JJA hypothetical protein YP_002735581.1 470577 R 488222 CDS YP_002735582.1 225854070 7680519 complement(471068..471355) 1 NC_012466.1 hypothetical protein 471355 7680519 SPJ_0486 Streptococcus pneumoniae JJA hypothetical protein YP_002735582.1 471068 R 488222 CDS YP_002735583.1 225854071 7679769 complement(471365..471775) 1 NC_012466.1 identified by match to protein family HMM PF01230; histidine triad domain protein 471775 7679769 SPJ_0487 Streptococcus pneumoniae JJA histidine triad domain protein YP_002735583.1 471365 R 488222 CDS YP_002735584.1 225854072 7679970 471843..472574 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 472574 7679970 SPJ_0488 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002735584.1 471843 D 488222 CDS YP_002735585.1 225854073 7680408 472571..473620 1 NC_012466.1 identified by match to protein family HMM PF05975; ABC transporter permease 473620 7680408 SPJ_0489 Streptococcus pneumoniae JJA ABC transporter permease YP_002735585.1 472571 D 488222 CDS YP_002735586.1 225854074 7679553 complement(473788..474117) 1 NC_012466.1 BlpT protein, fusion 474117 7679553 SPJ_0490 Streptococcus pneumoniae JJA BlpT protein, fusion YP_002735586.1 473788 R 488222 CDS YP_002735587.1 225854075 7680048 474393..474731 1 NC_012466.1 identified by match to protein family HMM PF04397; BlpS protein 474731 7680048 SPJ_0491 Streptococcus pneumoniae JJA BlpS protein YP_002735587.1 474393 D 488222 CDS YP_002735588.1 225854076 7679429 474736..475473 1 NC_012466.1 identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator BlpR 475473 7679429 SPJ_0492 Streptococcus pneumoniae JJA response regulator BlpR YP_002735588.1 474736 D 488222 CDS YP_002735589.1 225854077 7679786 475487..476827 1 NC_012466.1 identified by match to protein family HMM PF02518; histidine kinase 476827 7679786 SPJ_0493 Streptococcus pneumoniae JJA histidine kinase YP_002735589.1 475487 D 488222 CDS YP_002735590.1 225854078 7680398 complement(476898..477026) 1 NC_012466.1 identified by match to protein family HMM PF08128; match to protein family HMM TIGR01847; double glycine cleavage site bacteriolysin 477026 7680398 SPJ_0494 Streptococcus pneumoniae JJA double glycine cleavage site bacteriolysin YP_002735590.1 476898 R 488222 CDS YP_002735591.1 225854079 7678556 complement(477083..478444) 1 NC_012466.1 identified by match to protein family HMM TIGR01000; BlpC ABC transporter 478444 7678556 SPJ_0495 Streptococcus pneumoniae JJA BlpC ABC transporter YP_002735591.1 477083 R 488222 CDS YP_002735592.1 225854080 7679514 480894..481148 1 NC_012466.1 identified by match to protein family HMM TIGR01847; BlpM 481148 7679514 SPJ_0498 Streptococcus pneumoniae JJA BlpM YP_002735592.1 480894 D 488222 CDS YP_002735593.1 225854081 7679716 481164..481367 1 NC_012466.1 hypothetical protein 481367 7679716 SPJ_0499 Streptococcus pneumoniae JJA hypothetical protein YP_002735593.1 481164 D 488222 CDS YP_002735594.1 225854082 7679111 481611..481760 1 NC_012466.1 identified by match to protein family HMM TIGR01847; hypothetical protein 481760 7679111 SPJ_0500 Streptococcus pneumoniae JJA hypothetical protein YP_002735594.1 481611 D 488222 CDS YP_002735595.1 225854083 7678639 481742..481861 1 NC_012466.1 hypothetical protein 481861 7678639 SPJ_0501 Streptococcus pneumoniae JJA hypothetical protein YP_002735595.1 481742 D 488222 CDS YP_002735596.1 225854084 7680113 481864..481983 1 NC_012466.1 hypothetical protein 481983 7680113 SPJ_0502 Streptococcus pneumoniae JJA hypothetical protein YP_002735596.1 481864 D 488222 CDS YP_002735597.1 225854085 7679593 482281..482445 1 NC_012466.1 hypothetical protein 482445 7679593 SPJ_0503 Streptococcus pneumoniae JJA hypothetical protein YP_002735597.1 482281 D 488222 CDS YP_002735598.1 225854086 7679476 483023..483202 1 NC_012466.1 hypothetical protein 483202 7679476 SPJ_0505 Streptococcus pneumoniae JJA hypothetical protein YP_002735598.1 483023 D 488222 CDS YP_002735599.1 225854087 7680236 483474..483857 1 NC_012466.1 immunity protein BlpX 483857 7680236 SPJ_0506 Streptococcus pneumoniae JJA immunity protein BlpX YP_002735599.1 483474 D 488222 CDS YP_002735600.1 225854088 7678527 483909..484598 1 NC_012466.1 identified by match to protein family HMM PF02517; BlpY protein 484598 7678527 SPJ_0507 Streptococcus pneumoniae JJA BlpY protein YP_002735600.1 483909 D 488222 CDS YP_002735601.1 225854089 7680413 484640..484888 1 NC_012466.1 BlpZ 484888 7680413 SPJ_0508 Streptococcus pneumoniae JJA BlpZ YP_002735601.1 484640 D 488222 CDS YP_002735602.1 225854090 7678631 484918..485529 1 NC_012466.1 identified by match to protein family HMM PF02517; ABC transporter ATP-binding protein 485529 7678631 SPJ_0509 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002735602.1 484918 D 488222 CDS YP_002735603.1 225854091 7680367 485690..486484 1 NC_012466.1 identified by match to protein family HMM PF01636; phosphotransferase enzyme family 486484 7680367 SPJ_0510 Streptococcus pneumoniae JJA phosphotransferase enzyme family YP_002735603.1 485690 D 488222 CDS YP_002735604.1 225854092 7680516 486481..487116 1 NC_012466.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 487116 trmB 7680516 trmB Streptococcus pneumoniae JJA tRNA (guanine-N(7)-)-methyltransferase YP_002735604.1 486481 D 488222 CDS YP_002735605.1 225854093 7679709 487242..487721 1 NC_012466.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 487721 7679709 SPJ_0512 Streptococcus pneumoniae JJA hypothetical protein YP_002735605.1 487242 D 488222 CDS YP_002735606.1 225854094 7678954 487765..488901 1 NC_012466.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 488901 nusA 7678954 nusA Streptococcus pneumoniae JJA transcription elongation factor NusA YP_002735606.1 487765 D 488222 CDS YP_002735607.1 225854095 7679262 488923..489216 1 NC_012466.1 identified by match to protein family HMM PF04296; putative chain a, hypothetical cytosolic protein coded by gene from nusainfb, ylxr homologue 489216 7679262 SPJ_0514 Streptococcus pneumoniae JJA putative chain a, hypothetical cytosolic protein coded by gene from nusainfb, ylxr homologue YP_002735607.1 488923 D 488222 CDS YP_002735608.1 225854096 7678772 489209..489508 1 NC_012466.1 identified by match to protein family HMM PF01248; hypothetical protein 489508 7678772 SPJ_0515 Streptococcus pneumoniae JJA hypothetical protein YP_002735608.1 489209 D 488222 CDS YP_002735609.1 225854097 7680471 489525..492317 1 NC_012466.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 492317 infB 7680471 infB Streptococcus pneumoniae JJA translation initiation factor IF-2 YP_002735609.1 489525 D 488222 CDS YP_002735610.1 225854098 7679994 492568..492918 1 NC_012466.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 492918 rbfA 7679994 rbfA Streptococcus pneumoniae JJA ribosome-binding factor A YP_002735610.1 492568 D 488222 CDS YP_002735611.1 225854099 7678992 493197..493976 1 NC_012466.1 hypothetical protein 493976 7678992 SPJ_0518 Streptococcus pneumoniae JJA hypothetical protein YP_002735611.1 493197 D 488222 CDS YP_002735612.1 225854100 7678512 493978..494160 1 NC_012466.1 hypothetical protein 494160 7678512 SPJ_0519 Streptococcus pneumoniae JJA hypothetical protein YP_002735612.1 493978 D 488222 CDS YP_002735613.1 225854101 7679360 complement(494437..494589) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 494589 7679360 SPJ_0520 Streptococcus pneumoniae JJA hypothetical protein YP_002735613.1 494437 R 488222 CDS YP_002735614.1 225854102 7680094 494620..494853 1 NC_012466.1 identified by match to protein family HMM PF08984; hypothetical protein 494853 7680094 SPJ_0521 Streptococcus pneumoniae JJA hypothetical protein YP_002735614.1 494620 D 488222 CDS YP_002735615.1 225854103 7679065 494853..496187 1 NC_012466.1 identified by match to protein family HMM PF01814; match to protein family HMM PF04282; hemerythrin HHE cation binding domain subfamily, putative 496187 7679065 SPJ_0522 Streptococcus pneumoniae JJA hemerythrin HHE cation binding domain subfamily, putative YP_002735615.1 494853 D 488222 CDS YP_002735616.1 225854104 7679529 496197..496451 1 NC_012466.1 identified by match to protein family HMM PF08930; hypothetical protein 496451 7679529 SPJ_0523 Streptococcus pneumoniae JJA hypothetical protein YP_002735616.1 496197 D 488222 CDS YP_002735617.1 225854105 7680325 496547..496942 1 NC_012466.1 superfamily II helicase 496942 7680325 SPJ_0524 Streptococcus pneumoniae JJA superfamily II helicase YP_002735617.1 496547 D 488222 CDS YP_002735618.1 225854106 7678553 497354..497512 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 497512 7678553 SPJ_0525 Streptococcus pneumoniae JJA hypothetical protein YP_002735618.1 497354 D 488222 CDS YP_002735619.1 225854107 7679859 497496..497804 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 497804 7679859 SPJ_0526 Streptococcus pneumoniae JJA hypothetical protein YP_002735619.1 497496 D 488222 CDS YP_002735620.1 225854108 7680357 497791..498348 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 498348 7680357 SPJ_0527 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002735620.1 497791 D 488222 CDS YP_002735621.1 225854109 7678894 498350..499312 1 NC_012466.1 hypothetical protein 499312 7678894 SPJ_0528 Streptococcus pneumoniae JJA hypothetical protein YP_002735621.1 498350 D 488222 CDS YP_002735622.1 225854110 7679412 499324..501975 1 NC_012466.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 501975 valS 7679412 valS Streptococcus pneumoniae JJA valyl-tRNA synthetase YP_002735622.1 499324 D 488222 CDS YP_002735623.1 225854111 7679879 502045..502800 1 NC_012466.1 hypothetical protein 502800 7679879 SPJ_0530 Streptococcus pneumoniae JJA hypothetical protein YP_002735623.1 502045 D 488222 CDS YP_002735624.1 225854112 7678845 503085..503888 1 NC_012466.1 identified by match to protein family HMM PF02661; Fic protein family 503888 7678845 SPJ_0531 Streptococcus pneumoniae JJA Fic protein family YP_002735624.1 503085 D 488222 CDS YP_002735625.1 225854113 7679459 504157..506589 1 NC_012466.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF01896; match to protein family HMM PF04851; DEAD/DEAH box helicase, putative 506589 7679459 SPJ_0532 Streptococcus pneumoniae JJA DEAD/DEAH box helicase, putative YP_002735625.1 504157 D 488222 CDS YP_002735626.1 225854114 7679793 506780..506941 1 NC_012466.1 hypothetical protein 506941 7679793 SPJ_0533 Streptococcus pneumoniae JJA hypothetical protein YP_002735626.1 506780 D 488222 CDS YP_002735627.1 225854115 7680426 507310..508356 1 NC_012466.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 508356 pheS 7680426 pheS Streptococcus pneumoniae JJA phenylalanyl-tRNA synthetase subunit alpha YP_002735627.1 507310 D 488222 CDS YP_002735628.1 225854116 7679115 508356..508865 1 NC_012466.1 identified by match to protein family HMM PF00583; hypothetical acetyltransferase in PepI 3'region 508865 7679115 SPJ_0535 Streptococcus pneumoniae JJA hypothetical acetyltransferase in PepI 3'region YP_002735628.1 508356 D 488222 CDS YP_002735629.1 225854117 7679722 508942..511347 1 NC_012466.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 511347 pheT 7679722 pheT Streptococcus pneumoniae JJA phenylalanyl-tRNA synthetase subunit beta YP_002735629.1 508942 D 488222 CDS YP_002735630.1 225854118 7680145 complement(511415..512416) 1 NC_012466.1 identified by match to protein family HMM PF03372; endonuclease/exonuclease/phosphatase family 512416 7680145 SPJ_0537 Streptococcus pneumoniae JJA endonuclease/exonuclease/phosphatase family YP_002735630.1 511415 R 488222 CDS YP_002735631.1 225854119 7678467 512572..513066 1 NC_012466.1 transposase 513066 7678467 SPJ_0538 Streptococcus pneumoniae JJA transposase YP_002735631.1 512572 D 488222 CDS YP_002735632.1 225854120 7679463 513145..513411 1 NC_012466.1 identified by match to protein family HMM PF01381; helix-turn-helix domain protein 513411 7679463 SPJ_0539 Streptococcus pneumoniae JJA helix-turn-helix domain protein YP_002735632.1 513145 D 488222 CDS YP_002735633.1 225854121 7679516 513672..515921 1 NC_012466.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 515921 metE 7679516 metE Streptococcus pneumoniae JJA 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase YP_002735633.1 513672 D 488222 CDS YP_002735634.1 225854122 7680201 515985..516851 1 NC_012466.1 identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; 5,10-methylenetetrahydrofolate reductase 516851 metF 7680201 metF Streptococcus pneumoniae JJA 5,10-methylenetetrahydrofolate reductase YP_002735634.1 515985 D 488222 CDS YP_002735635.1 225854123 7679502 517536..519749 1 NC_012466.1 identified by match to protein family HMM PF00013; match to protein family HMM PF00575; match to protein family HMM PF01138; match to protein family HMM PF03725; match to protein family HMM PF03726; polynucleotide phosphorylase/polyadenylase 519749 7679502 SPJ_0542 Streptococcus pneumoniae JJA polynucleotide phosphorylase/polyadenylase YP_002735635.1 517536 D 488222 CDS YP_002735636.1 225854124 7679979 519765..520382 1 NC_012466.1 identified by match to protein family HMM TIGR01172; serine O-acetyltransferase 520382 cysE 7679979 cysE Streptococcus pneumoniae JJA serine O-acetyltransferase YP_002735636.1 519765 D 488222 CDS YP_002735637.1 225854125 7679358 520394..521278 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 521278 7679358 SPJ_0544 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002735637.1 520394 D 488222 CDS YP_002735638.1 225854126 7678689 521365..522708 1 NC_012466.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 522708 cysS 7678689 cysS Streptococcus pneumoniae JJA cysteinyl-tRNA synthetase YP_002735638.1 521365 D 488222 CDS YP_002735639.1 225854127 7680249 522701..523087 1 NC_012466.1 identified by match to protein family HMM PF00636; ribonuclease III family protein 523087 7680249 SPJ_0546 Streptococcus pneumoniae JJA ribonuclease III family protein YP_002735639.1 522701 D 488222 CDS YP_002735640.1 225854128 7679671 523091..523975 1 NC_012466.1 leucine-rich protein 523975 7679671 SPJ_0547 Streptococcus pneumoniae JJA leucine-rich protein YP_002735640.1 523091 D 488222 CDS YP_002735641.1 225854129 7679063 complement(524022..525278) 1 NC_012466.1 identified by match to protein family HMM PF01610; transposase 525278 7679063 SPJ_0548 Streptococcus pneumoniae JJA transposase YP_002735641.1 524022 R 488222 CDS YP_002735642.1 225854130 7678406 525641..526096 1 NC_012466.1 hypothetical protein 526096 7678406 SPJ_0549 Streptococcus pneumoniae JJA hypothetical protein YP_002735642.1 525641 D 488222 CDS YP_002735643.1 225854131 7679796 526093..526239 1 NC_012466.1 hypothetical protein 526239 7679796 SPJ_0550 Streptococcus pneumoniae JJA hypothetical protein YP_002735643.1 526093 D 488222 CDS YP_002735644.1 225854132 7678598 526385..526555 1 NC_012466.1 GBSi1, group II intron, maturase 526555 7678598 SPJ_0551 Streptococcus pneumoniae JJA GBSi1, group II intron, maturase YP_002735644.1 526385 D 488222 CDS YP_002735645.1 225854133 7680059 526909..528186 1 NC_012466.1 identified by match to protein family HMM PF02687; peptide ABC transporter permease 528186 7680059 SPJ_0552 Streptococcus pneumoniae JJA peptide ABC transporter permease YP_002735645.1 526909 D 488222 CDS YP_002735646.1 225854134 7679572 528199..528846 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 528846 7679572 SPJ_0553 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002735646.1 528199 D 488222 CDS YP_002735647.1 225854135 7679069 528898..530277 1 NC_012466.1 identified by match to protein family HMM PF02687; peptide ABC transporter permease 530277 7679069 SPJ_0554 Streptococcus pneumoniae JJA peptide ABC transporter permease YP_002735647.1 528898 D 488222 CDS YP_002735648.1 225854136 7678587 530589..531245 1 NC_012466.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; VncR, response regulator 531245 7678587 SPJ_0555 Streptococcus pneumoniae JJA VncR, response regulator YP_002735648.1 530589 D 488222 CDS YP_002735649.1 225854137 7679819 531242..532570 1 NC_012466.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; VncS, histidine kinase 532570 7679819 SPJ_0556 Streptococcus pneumoniae JJA VncS, histidine kinase YP_002735649.1 531242 D 488222 CDS YP_002735650.1 225854138 7679435 532711..533592 1 NC_012466.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 533592 fba 7679435 fba Streptococcus pneumoniae JJA fructose-bisphosphate aldolase YP_002735650.1 532711 D 488222 CDS YP_002735651.1 225854139 7678811 complement(533913..535103) 1 NC_012466.1 identified by match to protein family HMM PF00175; match to protein family HMM PF00970; match to protein family HMM PF01794; oxidoreductase, NAD-binding 535103 7678811 SPJ_0558 Streptococcus pneumoniae JJA oxidoreductase, NAD-binding YP_002735651.1 533913 R 488222 CDS YP_002735652.1 225854140 7680128 complement(535399..536058) 1 NC_012466.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamine ABC transporter permease 536058 7680128 SPJ_0559 Streptococcus pneumoniae JJA glutamine ABC transporter permease YP_002735652.1 535399 R 488222 CDS YP_002735653.1 225854141 7679490 complement(536068..536745) 1 NC_012466.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamine ABC transporter permease 536745 7679490 SPJ_0560 Streptococcus pneumoniae JJA glutamine ABC transporter permease YP_002735653.1 536068 R 488222 CDS YP_002735654.1 225854142 7679483 complement(536758..537522) 1 NC_012466.1 identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein 537522 7679483 SPJ_0561 Streptococcus pneumoniae JJA amino acid ABC transporter substrate-binding protein YP_002735654.1 536758 R 488222 CDS YP_002735655.1 225854143 7678967 complement(537562..538320) 1 NC_012466.1 identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 538320 7678967 SPJ_0562 Streptococcus pneumoniae JJA glutamine transport ATP-binding protein GlnQ YP_002735655.1 537562 R 488222 CDS YP_002735656.1 225854144 7679548 538597..540819 1 NC_012466.1 identified by match to protein family HMM PF01368; match to protein family HMM PF02272; match to protein family HMM TIGR00644; single-stranded-DNA-specific exonuclease RecJ 540819 recJ 7679548 recJ Streptococcus pneumoniae JJA single-stranded-DNA-specific exonuclease RecJ YP_002735656.1 538597 D 488222 CDS YP_002735657.1 225854145 7679927 540994..542655 1 NC_012466.1 identified by match to protein family HMM PF00753; match to protein family HMM PF07521; metallo-beta-lactamase family protein 542655 7679927 SPJ_0564 Streptococcus pneumoniae JJA metallo-beta-lactamase family protein YP_002735657.1 540994 D 488222 CDS YP_002735658.1 225854146 7680503 542724..543503 1 NC_012466.1 identified by match to protein family HMM PF00756; tributyrin esterase 543503 7680503 SPJ_0565 Streptococcus pneumoniae JJA tributyrin esterase YP_002735658.1 542724 D 488222 CDS YP_002735659.1 225854147 7679315 543615..544835 1 NC_012466.1 identified by match to protein family HMM PF02388; serine/alanine-adding enzyme MurM 544835 7679315 SPJ_0566 Streptococcus pneumoniae JJA serine/alanine-adding enzyme MurM YP_002735659.1 543615 D 488222 CDS YP_002735660.1 225854148 7679752 544840..546072 1 NC_012466.1 identified by match to protein family HMM PF02388; alanine adding enzyme 546072 7679752 SPJ_0567 Streptococcus pneumoniae JJA alanine adding enzyme YP_002735660.1 544840 D 488222 CDS YP_002735661.1 225854149 7680447 546151..546852 1 NC_012466.1 identified by match to protein family HMM PF00413; matrixin family 546852 7680447 SPJ_0568 Streptococcus pneumoniae JJA matrixin family YP_002735661.1 546151 D 488222 CDS YP_002735662.1 225854150 7678744 546892..548739 1 NC_012466.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 548739 uvrC 7678744 uvrC Streptococcus pneumoniae JJA excinuclease ABC subunit C YP_002735662.1 546892 D 488222 CDS YP_002735663.1 225854151 7680355 complement(549746..550546) 1 NC_012466.1 identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein - glutamine transport/Major cell binding factor 550546 7680355 SPJ_0572 Streptococcus pneumoniae JJA ABC transporter substrate-binding protein - glutamine transport/Major cell binding factor YP_002735663.1 549746 R 488222 CDS YP_002735664.1 225854152 7679623 550717..551322 1 NC_012466.1 identified by match to protein family HMM PF00881; oxidoreductase 551322 7679623 SPJ_0573 Streptococcus pneumoniae JJA oxidoreductase YP_002735664.1 550717 D 488222 CDS YP_002735665.1 225854153 7679100 551335..552735 1 NC_012466.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 552735 pepV 7679100 pepV Streptococcus pneumoniae JJA dipeptidase PepV YP_002735665.1 551335 D 488222 CDS YP_002735666.1 225854154 7678618 552789..553367 1 NC_012466.1 identified by match to protein family HMM PF03167; uracil DNA glycosylase family protein 553367 7678618 SPJ_0575 Streptococcus pneumoniae JJA uracil DNA glycosylase family protein YP_002735666.1 552789 D 488222 CDS YP_002735667.1 225854155 7678609 553527..553679 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 553679 7678609 SPJ_0576 Streptococcus pneumoniae JJA hypothetical protein YP_002735667.1 553527 D 488222 CDS YP_002735668.1 225854156 7679785 553680..553814 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 553814 7679785 SPJ_0577 Streptococcus pneumoniae JJA hypothetical protein YP_002735668.1 553680 D 488222 CDS YP_002735669.1 225854157 7679351 553985..555310 1 NC_012466.1 identified by match to protein family HMM PF05525; match to protein family HMM TIGR00796; branched-chain amino acid transport system II carrier protein 555310 brnQ 7679351 brnQ Streptococcus pneumoniae JJA branched-chain amino acid transport system II carrier protein YP_002735669.1 553985 D 488222 CDS YP_002735670.1 225854158 7678789 555408..556445 1 NC_012466.1 identified by match to protein family HMM PF05343; peptidase, M42 556445 7678789 SPJ_0579 Streptococcus pneumoniae JJA peptidase, M42 YP_002735670.1 555408 D 488222 CDS YP_002735671.1 225854159 7678915 556447..556908 1 NC_012466.1 identified by match to protein family HMM PF01230; HIT family protein 556908 7678915 SPJ_0580 Streptococcus pneumoniae JJA HIT family protein YP_002735671.1 556447 D 488222 CDS YP_002735672.1 225854160 7679289 556926..557648 1 NC_012466.1 identified by match to protein family HMM PF02557; D-alanyl-D-alanine carboxypeptidase 557648 7679289 SPJ_0581 Streptococcus pneumoniae JJA D-alanyl-D-alanine carboxypeptidase YP_002735672.1 556926 D 488222 CDS YP_002735673.1 225854161 7679626 557765..558190 1 NC_012466.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 558190 rplK 7679626 rplK Streptococcus pneumoniae JJA 50S ribosomal protein L11 YP_002735673.1 557765 D 488222 CDS YP_002735674.1 225854162 7679825 558398..559087 1 NC_012466.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 559087 rplA 7679825 rplA Streptococcus pneumoniae JJA 50S ribosomal protein L1 YP_002735674.1 558398 D 488222 CDS YP_002735675.1 225854163 7680420 complement(559176..559703) 1 NC_012466.1 transposase 559703 7680420 SPJ_0584 Streptococcus pneumoniae JJA transposase YP_002735675.1 559176 R 488222 CDS YP_002735676.1 225854164 7678850 complement(559700..560482) 1 NC_012466.1 identified by match to protein family HMM PF01610; transposase 560482 7678850 SPJ_0585 Streptococcus pneumoniae JJA transposase YP_002735676.1 559700 R 488222 CDS YP_002735677.1 225854165 7679966 complement(561046..561192) 1 NC_012466.1 chlorohydrolase 561192 7679966 SPJ_0586 Streptococcus pneumoniae JJA chlorohydrolase YP_002735677.1 561046 R 488222 CDS YP_002735678.1 225854166 7680530 561206..561568 1 NC_012466.1 hypothetical protein 561568 7680530 SPJ_0587 Streptococcus pneumoniae JJA hypothetical protein YP_002735678.1 561206 D 488222 CDS YP_002735679.1 225854167 7678474 562613..563605 1 NC_012466.1 identified by match to protein family HMM PF00005; polysaccharide ABC transporter ATP-binding protein 563605 7678474 SPJ_0588 Streptococcus pneumoniae JJA polysaccharide ABC transporter ATP-binding protein YP_002735679.1 562613 D 488222 CDS YP_002735680.1 225854168 7679093 563607..564425 1 NC_012466.1 identified by match to protein family HMM PF06182; membrane protein 564425 7679093 SPJ_0589 Streptococcus pneumoniae JJA membrane protein YP_002735680.1 563607 D 488222 CDS YP_002735681.1 225854169 7679101 564427..565212 1 NC_012466.1 identified by match to protein family HMM PF06182; ABC transporter permease 565212 7679101 SPJ_0590 Streptococcus pneumoniae JJA ABC transporter permease YP_002735681.1 564427 D 488222 CDS YP_002735682.1 225854170 7678685 565251..565622 1 NC_012466.1 acetyltransferase, gnat family 565622 7678685 SPJ_0591 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002735682.1 565251 D 488222 CDS YP_002735683.1 225854171 7678944 566315..572731 1 NC_012466.1 identified by match to protein family HMM PF00082; match to protein family HMM PF00746; match to protein family HMM PF02225; match to protein family HMM PF06280; match to protein family HMM TIGR01167; serine protease 572731 7678944 SPJ_0592 Streptococcus pneumoniae JJA serine protease YP_002735683.1 566315 D 488222 CDS YP_002735684.1 225854172 7678495 573357..573833 1 NC_012466.1 identified by match to protein family HMM PF00359; phosphotransferase system sugar-specific EII component 573833 7678495 SPJ_0593 Streptococcus pneumoniae JJA phosphotransferase system sugar-specific EII component YP_002735684.1 573357 D 488222 CDS YP_002735685.1 225854173 7680460 573871..574176 1 NC_012466.1 PTS system, galactose-specific IIB component 574176 7680460 SPJ_0594 Streptococcus pneumoniae JJA PTS system, galactose-specific IIB component YP_002735685.1 573871 D 488222 CDS YP_002735686.1 225854174 7680019 574224..575699 1 NC_012466.1 identified by match to protein family HMM PF03611; phosphotransferase system sugar-specific EII component 575699 7680019 SPJ_0595 Streptococcus pneumoniae JJA phosphotransferase system sugar-specific EII component YP_002735686.1 574224 D 488222 CDS YP_002735687.1 225854175 7678921 576049..582750 1 NC_012466.1 identified by match to protein family HMM PF00703; match to protein family HMM PF00746; match to protein family HMM PF02836; match to protein family HMM PF02837; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07532; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-galactosidase 582750 7678921 SPJ_0596 Streptococcus pneumoniae JJA beta-galactosidase YP_002735687.1 576049 D 488222 CDS YP_002735688.1 225854176 7680341 complement(582998..583621) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 583621 7680341 SPJ_0597 Streptococcus pneumoniae JJA hypothetical protein YP_002735688.1 582998 R 488222 CDS YP_002735689.1 225854177 7680191 complement(583609..583854) 1 NC_012466.1 transposase 583854 7680191 SPJ_0598 Streptococcus pneumoniae JJA transposase YP_002735689.1 583609 R 488222 CDS YP_002735690.1 225854178 7679707 583824..583991 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 583991 7679707 SPJ_0599 Streptococcus pneumoniae JJA hypothetical protein YP_002735690.1 583824 D 488222 CDS YP_002735691.1 225854179 7679391 complement(584065..584424) 1 NC_012466.1 integral membrane protein 584424 7679391 SPJ_0600 Streptococcus pneumoniae JJA integral membrane protein YP_002735691.1 584065 R 488222 CDS YP_002735692.1 225854180 7678986 585456..586013 1 NC_012466.1 identified by match to protein family HMM PF06962; SAM-dependent methyltransferase 586013 7678986 SPJ_0603 Streptococcus pneumoniae JJA SAM-dependent methyltransferase YP_002735692.1 585456 D 488222 CDS YP_002735693.1 225854181 7680228 586006..586260 1 NC_012466.1 hypothetical protein 586260 7680228 SPJ_0604 Streptococcus pneumoniae JJA hypothetical protein YP_002735693.1 586006 D 488222 CDS YP_002735694.1 225854182 7679753 586272..588326 1 NC_012466.1 identified by match to protein family HMM PF00999; sodium/hydrogen exchanger family protein 588326 7679753 SPJ_0605 Streptococcus pneumoniae JJA sodium/hydrogen exchanger family protein YP_002735694.1 586272 D 488222 CDS YP_002735695.1 225854183 7679233 588505..589365 1 NC_012466.1 identified by match to protein family HMM PF03631; ribonuclease BN 589365 7679233 SPJ_0606 Streptococcus pneumoniae JJA ribonuclease BN YP_002735695.1 588505 D 488222 CDS YP_002735696.1 225854184 7680227 589576..590286 1 NC_012466.1 identified by match to protein family HMM PF02683; cytoChrome c-type biogenesis protein 590286 7680227 SPJ_0607 Streptococcus pneumoniae JJA cytoChrome c-type biogenesis protein YP_002735696.1 589576 D 488222 CDS YP_002735697.1 225854185 7680449 590306..590872 1 NC_012466.1 identified by match to protein family HMM PF00578; match to protein family HMM PF08534; thioredoxin family protein 590872 7680449 SPJ_0608 Streptococcus pneumoniae JJA thioredoxin family protein YP_002735697.1 590306 D 488222 CDS YP_002735698.1 225854186 7679991 590883..591995 1 NC_012466.1 identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; peptide methionine sulfoxide reductase MsrA/msrB 591995 7679991 SPJ_0609 Streptococcus pneumoniae JJA peptide methionine sulfoxide reductase MsrA/msrB YP_002735698.1 590883 D 488222 CDS YP_002735699.1 225854187 7679920 592353..593090 1 NC_012466.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00165; response regulator 593090 7679920 SPJ_0610 Streptococcus pneumoniae JJA response regulator YP_002735699.1 592353 D 488222 CDS YP_002735700.1 225854188 7679503 593087..594778 1 NC_012466.1 identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF02743; match to protein family HMM PF06580; histidine kinase 594778 7679503 SPJ_0611 Streptococcus pneumoniae JJA histidine kinase YP_002735700.1 593087 D 488222 CDS YP_002735701.1 225854189 7679398 594894..595457 1 NC_012466.1 identified by match to protein family HMM PF04260; match to protein family HMM TIGR01440; hypothetical protein 595457 7679398 SPJ_0612 Streptococcus pneumoniae JJA hypothetical protein YP_002735701.1 594894 D 488222 CDS YP_002735702.1 225854190 7679179 601209..602930 1 NC_012466.1 identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553; chorismate binding enzyme 602930 7679179 SPJ_0615 Streptococcus pneumoniae JJA chorismate binding enzyme YP_002735702.1 601209 D 488222 CDS YP_002735703.1 225854191 7680485 603050..604576 1 NC_012466.1 pneumococcal surface protein, putative 604576 7680485 SPJ_0616 Streptococcus pneumoniae JJA pneumococcal surface protein, putative YP_002735703.1 603050 D 488222 CDS YP_002735704.1 225854192 7679011 complement(604581..604724) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 604724 7679011 SPJ_0617 Streptococcus pneumoniae JJA hypothetical protein YP_002735704.1 604581 R 488222 CDS YP_002735705.1 225854193 7678501 604741..605526 1 NC_012466.1 putative endo-beta-N-acetylglucosaminidase (Murein hydrolase) 605526 7678501 SPJ_0618 Streptococcus pneumoniae JJA putative endo-beta-N-acetylglucosaminidase (Murein hydrolase) YP_002735705.1 604741 D 488222 CDS YP_002735706.1 225854194 7680461 605717..606676 1 NC_012466.1 identified by match to protein family HMM PF00480; match to protein family HMM TIGR00744; glucokinase (Glucose kinase) 606676 7680461 SPJ_0619 Streptococcus pneumoniae JJA glucokinase (Glucose kinase) YP_002735706.1 605717 D 488222 CDS YP_002735707.1 225854195 7680005 606773..607612 1 NC_012466.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 607612 thyA 7680005 thyA Streptococcus pneumoniae JJA thymidylate synthase YP_002735707.1 606773 D 488222 CDS YP_002735708.1 225854196 7679097 complement(607660..607830) 1 NC_012466.1 hypothetical protein 607830 7679097 SPJ_0621 Streptococcus pneumoniae JJA hypothetical protein YP_002735708.1 607660 R 488222 CDS YP_002735709.1 225854197 7678476 607927..608835 1 NC_012466.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 608835 miaA 7678476 miaA Streptococcus pneumoniae JJA tRNA delta(2)-isopentenylpyrophosphate transferase YP_002735709.1 607927 D 488222 CDS YP_002735710.1 225854198 7680050 608828..610066 1 NC_012466.1 identified by match to protein family HMM PF01926; match to protein family HMM TIGR00231; match to protein family HMM TIGR03156; GTP-binding proten HflX 610066 hflX 7680050 hflX Streptococcus pneumoniae JJA GTP-binding proten HflX YP_002735710.1 608828 D 488222 CDS YP_002735711.1 225854199 7679549 610059..610682 1 NC_012466.1 cystathionine beta-lyase 610682 7679549 SPJ_0624 Streptococcus pneumoniae JJA cystathionine beta-lyase YP_002735711.1 610059 D 488222 CDS YP_002735712.1 225854200 7679080 610697..611626 1 NC_012466.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 611626 rnz 7679080 rnz Streptococcus pneumoniae JJA ribonuclease Z YP_002735712.1 610697 D 488222 CDS YP_002735713.1 225854201 7678644 611647..612402 1 NC_012466.1 identified by match to protein family HMM PF00106; match to protein family HMM PF08659; oxidoreductase 612402 7678644 SPJ_0626 Streptococcus pneumoniae JJA oxidoreductase YP_002735713.1 611647 D 488222 CDS YP_002735714.1 225854202 7678754 complement(612456..613424) 1 NC_012466.1 identified by match to protein family HMM PF00126; regulatory function on capsule expression 613424 7678754 SPJ_0627 Streptococcus pneumoniae JJA regulatory function on capsule expression YP_002735714.1 612456 R 488222 CDS YP_002735715.1 225854203 7680457 613428..613697 1 NC_012466.1 identified by match to protein family HMM PF06014; hypothetical protein 613697 7680457 SPJ_0628 Streptococcus pneumoniae JJA hypothetical protein YP_002735715.1 613428 D 488222 CDS YP_002735716.1 225854204 7680077 613697..614077 1 NC_012466.1 identified by match to protein family HMM PF00581; rhodanese family protein 614077 7680077 SPJ_0629 Streptococcus pneumoniae JJA rhodanese family protein YP_002735716.1 613697 D 488222 CDS YP_002735717.1 225854205 7679622 complement(614433..615158) 1 NC_012466.1 identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A, putative 615158 7679622 SPJ_0630 Streptococcus pneumoniae JJA ribosomal small subunit pseudouridine synthase A, putative YP_002735717.1 614433 R 488222 CDS YP_002735718.1 225854206 7679420 615320..617161 1 NC_012466.1 identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394; GTP-binding protein TypA/BipA 617161 typA 7679420 typA Streptococcus pneumoniae JJA GTP-binding protein TypA/BipA YP_002735718.1 615320 D 488222 CDS YP_002735719.1 225854207 7679915 617181..617435 1 NC_012466.1 hypothetical protein 617435 7679915 SPJ_0632 Streptococcus pneumoniae JJA hypothetical protein YP_002735719.1 617181 D 488222 CDS YP_002735720.1 225854208 7678933 617752..617883 1 NC_012466.1 hypothetical protein 617883 7678933 SPJ_0633 Streptococcus pneumoniae JJA hypothetical protein YP_002735720.1 617752 D 488222 CDS YP_002735721.1 225854209 7680079 620205..620846 1 NC_012466.1 identified by match to protein family HMM PF00005; Na+ ABC transporter ATP-binding protein 620846 7680079 SPJ_0637 Streptococcus pneumoniae JJA Na+ ABC transporter ATP-binding protein YP_002735721.1 620205 D 488222 CDS YP_002735722.1 225854210 7678508 620950..622302 1 NC_012466.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 622302 murD 7678508 murD Streptococcus pneumoniae JJA UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_002735722.1 620950 D 488222 CDS YP_002735723.1 225854211 7678801 622306..623364 1 NC_012466.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase 623364 murG 7678801 murG Streptococcus pneumoniae JJA UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase YP_002735723.1 622306 D 488222 CDS YP_002735724.1 225854212 7679481 623374..624573 1 NC_012466.1 identified by match to protein family HMM PF03799; match to protein family HMM PF08478; cell division protein DivIB 624573 7679481 SPJ_0640 Streptococcus pneumoniae JJA cell division protein DivIB YP_002735724.1 623374 D 488222 CDS YP_002735725.1 225854213 7680446 624806..625507 1 NC_012466.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 625507 pyrF 7680446 pyrF Streptococcus pneumoniae JJA orotidine 5'-phosphate decarboxylase YP_002735725.1 624806 D 488222 CDS YP_002735726.1 225854214 7678743 625541..626173 1 NC_012466.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 626173 pyrE 7678743 pyrE Streptococcus pneumoniae JJA orotate phosphoribosyltransferase YP_002735726.1 625541 D 488222 CDS YP_002735727.1 225854215 7680100 626634..626756 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 626756 7680100 SPJ_0643 Streptococcus pneumoniae JJA hypothetical protein YP_002735727.1 626634 D 488222 CDS YP_002735728.1 225854216 7678650 626852..627616 1 NC_012466.1 hypothetical protein 627616 7678650 SPJ_0644 Streptococcus pneumoniae JJA hypothetical protein YP_002735728.1 626852 D 488222 CDS YP_002735729.1 225854217 7679161 627616..628368 1 NC_012466.1 lipoprotein, putative 628368 7679161 SPJ_0645 Streptococcus pneumoniae JJA lipoprotein, putative YP_002735729.1 627616 D 488222 CDS YP_002735730.1 225854218 7679504 628372..629076 1 NC_012466.1 hypothetical protein 629076 7679504 SPJ_0646 Streptococcus pneumoniae JJA hypothetical protein YP_002735730.1 628372 D 488222 CDS YP_002735731.1 225854219 7678773 629073..629720 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 629720 7678773 SPJ_0647 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002735731.1 629073 D 488222 CDS YP_002735732.1 225854220 7679770 complement(630673..631431) 1 NC_012466.1 identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 631431 7679770 SPJ_0649 Streptococcus pneumoniae JJA glutamine transport ATP-binding protein GlnQ YP_002735732.1 630673 R 488222 CDS YP_002735733.1 225854221 7679438 complement(631432..632109) 1 NC_012466.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamine ABC transporter permease 632109 7679438 SPJ_0650 Streptococcus pneumoniae JJA glutamine ABC transporter permease YP_002735733.1 631432 R 488222 CDS YP_002735734.1 225854222 7680049 complement(632069..632689) 1 NC_012466.1 amino acid ABC transporter permease 632689 7680049 SPJ_0651 Streptococcus pneumoniae JJA amino acid ABC transporter permease YP_002735734.1 632069 R 488222 CDS YP_002735735.1 225854223 7678577 complement(632816..632959) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 632959 7678577 SPJ_0652 Streptococcus pneumoniae JJA hypothetical protein YP_002735735.1 632816 R 488222 CDS YP_002735736.1 225854224 7680180 632963..633109 1 NC_012466.1 hypothetical protein 633109 7680180 SPJ_0653 Streptococcus pneumoniae JJA hypothetical protein YP_002735736.1 632963 D 488222 CDS YP_002735737.1 225854225 7679933 633237..634727 1 NC_012466.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 634727 lysS 7679933 lysS Streptococcus pneumoniae JJA lysyl-tRNA synthetase YP_002735737.1 633237 D 488222 CDS YP_002735738.1 225854226 7679221 635352..636488 1 NC_012466.1 identified by match to protein family HMM PF01070; match to protein family HMM PF01180; match to protein family HMM TIGR02708; L-lactate oxidase 636488 lctO 7679221 lctO Streptococcus pneumoniae JJA L-lactate oxidase YP_002735738.1 635352 D 488222 CDS YP_002735739.1 225854227 7680067 637045..637713 1 NC_012466.1 identified by match to protein family HMM PF03070; tena/thi-4 family 637713 7680067 SPJ_0656 Streptococcus pneumoniae JJA tena/thi-4 family YP_002735739.1 637045 D 488222 CDS YP_002735740.1 225854228 7680494 637950..638732 1 NC_012466.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 638732 thiM 7680494 thiM Streptococcus pneumoniae JJA hydroxyethylthiazole kinase YP_002735740.1 637950 D 488222 CDS YP_002735741.1 225854229 7679182 638734..639363 1 NC_012466.1 identified by match to protein family HMM PF02581; match to protein family HMM TIGR00693; thiamine-phosphate pyrophosphorylase 639363 thiE1 7679182 thiE1 Streptococcus pneumoniae JJA thiamine-phosphate pyrophosphorylase YP_002735741.1 638734 D 488222 CDS YP_002735742.1 225854230 7678574 639922..640482 1 NC_012466.1 cobalt ABC transporter permease 640482 7678574 SPJ_0659 Streptococcus pneumoniae JJA cobalt ABC transporter permease YP_002735742.1 639922 D 488222 CDS YP_002735743.1 225854231 7679681 640483..641868 1 NC_012466.1 identified by match to protein family HMM PF00005; cobalt ABC transporter ATP-binding protein 641868 7679681 SPJ_0660 Streptococcus pneumoniae JJA cobalt ABC transporter ATP-binding protein YP_002735743.1 640483 D 488222 CDS YP_002735744.1 225854232 7679088 641870..642520 1 NC_012466.1 hypothetical protein 642520 7679088 SPJ_0661 Streptococcus pneumoniae JJA hypothetical protein YP_002735744.1 641870 D 488222 CDS YP_002735745.1 225854233 7678477 642531..643223 1 NC_012466.1 identified by match to protein family HMM PF03070; tena/thi-4 family 643223 7678477 SPJ_0662 Streptococcus pneumoniae JJA tena/thi-4 family YP_002735745.1 642531 D 488222 CDS YP_002735746.1 225854234 7680065 643228..643752 1 NC_012466.1 identified by match to protein family HMM TIGR02359; ThiW protein 643752 thiW 7680065 thiW Streptococcus pneumoniae JJA ThiW protein YP_002735746.1 643228 D 488222 CDS YP_002735747.1 225854235 7679454 643752..644555 1 NC_012466.1 identified by match to protein family HMM PF02110; hydroxyethylthiazole kinase 644555 7679454 SPJ_0664 Streptococcus pneumoniae JJA hydroxyethylthiazole kinase YP_002735747.1 643752 D 488222 CDS YP_002735748.1 225854236 7678833 644548..645180 1 NC_012466.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 645180 thiE 7678833 thiE Streptococcus pneumoniae JJA thiamine-phosphate pyrophosphorylase YP_002735748.1 644548 D 488222 CDS YP_002735749.1 225854237 7679400 complement(645390..646181) 1 NC_012466.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 646181 thiD 7679400 thiD Streptococcus pneumoniae JJA phosphomethylpyrimidine kinase YP_002735749.1 645390 R 488222 CDS YP_002735750.1 225854238 7678880 646547..646942 1 NC_012466.1 identified by match to protein family HMM PF03965; match to protein family HMM TIGR02698; copper transport repressor, CopY/TcrY family 646942 7678880 SPJ_0667 Streptococcus pneumoniae JJA copper transport repressor, CopY/TcrY family YP_002735750.1 646547 D 488222 CDS YP_002735751.1 225854239 7680312 646953..647324 1 NC_012466.1 hypothetical protein 647324 7680312 SPJ_0668 Streptococcus pneumoniae JJA hypothetical protein YP_002735751.1 646953 D 488222 CDS YP_002735752.1 225854240 7679860 647334..649577 1 NC_012466.1 identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM PF08282; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525; copper-translocating P-type ATPase 649577 7679860 SPJ_0669 Streptococcus pneumoniae JJA copper-translocating P-type ATPase YP_002735752.1 647334 D 488222 CDS YP_002735753.1 225854241 7680032 649784..651559 1 NC_012466.1 identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR02720; pyruvate oxidase 651559 spxB 7680032 spxB Streptococcus pneumoniae JJA pyruvate oxidase YP_002735753.1 649784 D 488222 CDS YP_002735754.1 225854242 7678450 651670..652017 1 NC_012466.1 identified by match to protein family HMM PF00903; glyoxalase family protein 652017 7678450 SPJ_0671 Streptococcus pneumoniae JJA glyoxalase family protein YP_002735754.1 651670 D 488222 CDS YP_002735755.1 225854243 7679106 complement(652134..652295) 1 NC_012466.1 hypothetical protein 652295 7679106 SPJ_0672 Streptococcus pneumoniae JJA hypothetical protein YP_002735755.1 652134 R 488222 CDS YP_002735756.1 225854244 7679584 complement(652675..652941) 1 NC_012466.1 transposase 652941 7679584 SPJ_0673 Streptococcus pneumoniae JJA transposase YP_002735756.1 652675 R 488222 CDS YP_002735757.1 225854245 7679287 653869..654813 1 NC_012466.1 identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218; mannose-6-phosphate isomerase, class I 654813 manA 7679287 manA Streptococcus pneumoniae JJA mannose-6-phosphate isomerase, class I YP_002735757.1 653869 D 488222 CDS YP_002735758.1 225854246 7679378 complement(654835..656316) 1 NC_012466.1 identified by match to protein family HMM PF00209; sodium-dependent transporter 656316 7679378 SPJ_0676 Streptococcus pneumoniae JJA sodium-dependent transporter YP_002735758.1 654835 R 488222 CDS YP_002735759.1 225854247 7679835 656527..656640 1 NC_012466.1 transcriptional regulator, MerR family 656640 7679835 SPJ_0677 Streptococcus pneumoniae JJA transcriptional regulator, MerR family YP_002735759.1 656527 D 488222 CDS YP_002735760.1 225854248 7679508 656641..657147 1 NC_012466.1 identified by match to protein family HMM PF07739; regulator of the multidrug efflux pump PmrA 657147 7679508 SPJ_0678 Streptococcus pneumoniae JJA regulator of the multidrug efflux pump PmrA YP_002735760.1 656641 D 488222 CDS YP_002735761.1 225854249 7678889 complement(657167..657583) 1 NC_012466.1 identified by match to protein family HMM PF00293; MutT/nudix family protein 657583 7678889 SPJ_0679 Streptococcus pneumoniae JJA MutT/nudix family protein YP_002735761.1 657167 R 488222 CDS YP_002735762.1 225854250 7679136 complement(657642..658817) 1 NC_012466.1 identified by match to protein family HMM PF03486; match to protein family HMM TIGR00275; hypothetical protein 658817 7679136 SPJ_0680 Streptococcus pneumoniae JJA hypothetical protein YP_002735762.1 657642 R 488222 CDS YP_002735763.1 225854251 7679736 complement(658876..659721) 1 NC_012466.1 identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; hypothetical protein 659721 7679736 SPJ_0681 Streptococcus pneumoniae JJA hypothetical protein YP_002735763.1 658876 R 488222 CDS YP_002735764.1 225854252 7678395 659846..660403 1 NC_012466.1 identified by match to protein family HMM PF00440; TetR family transcriptional regulator 660403 7678395 SPJ_0682 Streptococcus pneumoniae JJA TetR family transcriptional regulator YP_002735764.1 659846 D 488222 CDS YP_002735765.1 225854253 7679141 660422..660889 1 NC_012466.1 identified by match to protein family HMM PF00383; ComE operon protein 2 660889 7679141 SPJ_0683 Streptococcus pneumoniae JJA ComE operon protein 2 YP_002735765.1 660422 D 488222 CDS YP_002735766.1 225854254 7680011 660957..661607 1 NC_012466.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 661607 upp 7680011 upp Streptococcus pneumoniae JJA uracil phosphoribosyltransferase YP_002735766.1 660957 D 488222 CDS YP_002735767.1 225854255 7680127 661781..662371 1 NC_012466.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 662371 clpP 7680127 clpP Streptococcus pneumoniae JJA ATP-dependent Clp protease proteolytic subunit YP_002735767.1 661781 D 488222 CDS YP_002735768.1 225854256 7679269 662450..662698 1 NC_012466.1 hypothetical protein 662698 7679269 SPJ_0686 Streptococcus pneumoniae JJA hypothetical protein YP_002735768.1 662450 D 488222 CDS YP_002735769.1 225854257 7680030 662799..663959 1 NC_012466.1 identified by match to protein family HMM PF01094; ABC transporter substrate-binding protein - branched chain amino acid transport 663959 7680030 SPJ_0687 Streptococcus pneumoniae JJA ABC transporter substrate-binding protein - branched chain amino acid transport YP_002735769.1 662799 D 488222 CDS YP_002735770.1 225854258 7679735 664227..665096 1 NC_012466.1 identified by match to protein family HMM PF02653; high-affinity branched-chain amino acid transport system permeaseprotein LivH (LIV-I protein H) 665096 7679735 SPJ_0688 Streptococcus pneumoniae JJA high-affinity branched-chain amino acid transport system permeaseprotein LivH (LIV-I protein H) YP_002735770.1 664227 D 488222 CDS YP_002735771.1 225854259 7680226 665100..666056 1 NC_012466.1 identified by match to protein family HMM PF02653; branched-chain amino acid ABC transporter permease 666056 7680226 SPJ_0689 Streptococcus pneumoniae JJA branched-chain amino acid ABC transporter permease YP_002735771.1 665100 D 488222 CDS YP_002735772.1 225854260 7679441 666056..666820 1 NC_012466.1 identified by match to protein family HMM PF00005; high-affinity branched-chain amino acid transport ATP-binding proteinlivG (LIV-I protein G) 666820 7679441 SPJ_0690 Streptococcus pneumoniae JJA high-affinity branched-chain amino acid transport ATP-binding proteinlivG (LIV-I protein G) YP_002735772.1 666056 D 488222 CDS YP_002735773.1 225854261 7678803 666820..667530 1 NC_012466.1 identified by match to protein family HMM PF00005; high-affinity branched-chain amino acid transport ATP-binding proteinlivF (LIV-I protein F) 667530 7678803 SPJ_0691 Streptococcus pneumoniae JJA high-affinity branched-chain amino acid transport ATP-binding proteinlivF (LIV-I protein F) YP_002735773.1 666820 D 488222 CDS YP_002735774.1 225854262 7680374 667944..668600 1 NC_012466.1 identified by match to protein family HMM PF00571; AcuB family protein 668600 7680374 SPJ_0692 Streptococcus pneumoniae JJA AcuB family protein YP_002735774.1 667944 D 488222 CDS YP_002735775.1 225854263 7679631 668814..669803 1 NC_012466.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 669803 prfB 7679631 prfB Streptococcus pneumoniae JJA peptide chain release factor 2 YP_002735775.1 668814 D 488222 CDS YP_002735776.1 225854264 7679172 669821..670513 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM TIGR02673; cell division ATP-binding protein FtsE 670513 ftsE 7679172 ftsE Streptococcus pneumoniae JJA cell division ATP-binding protein FtsE YP_002735776.1 669821 D 488222 CDS YP_002735777.1 225854265 7678399 670506..671432 1 NC_012466.1 identified by match to protein family HMM PF02687; cell division ABC transporter, permease protein FtsX 671432 7678399 SPJ_0695 Streptococcus pneumoniae JJA cell division ABC transporter, permease protein FtsX YP_002735777.1 670506 D 488222 CDS YP_002735778.1 225854266 7679617 671718..673898 1 NC_012466.1 identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR02003; pts system, iibc component 673898 7679617 SPJ_0696 Streptococcus pneumoniae JJA pts system, iibc component YP_002735778.1 671718 D 488222 CDS YP_002735779.1 225854267 7680025 673950..674765 1 NC_012466.1 identified by match to protein family HMM PF03372; metal-dependent hydrolase 674765 7680025 SPJ_0697 Streptococcus pneumoniae JJA metal-dependent hydrolase YP_002735779.1 673950 D 488222 CDS YP_002735780.1 225854268 7679270 674905..676248 1 NC_012466.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; superfamily II DNA and RNA helicase 676248 7679270 SPJ_0698 Streptococcus pneumoniae JJA superfamily II DNA and RNA helicase YP_002735780.1 674905 D 488222 CDS YP_002735781.1 225854269 7678760 676464..677654 1 NC_012466.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 677654 metK 7678760 metK Streptococcus pneumoniae JJA S-adenosylmethionine synthetase YP_002735781.1 676464 D 488222 CDS YP_002735782.1 225854270 7678846 complement(677744..677908) 1 NC_012466.1 hypothetical protein 677908 7678846 SPJ_0700 Streptococcus pneumoniae JJA hypothetical protein YP_002735782.1 677744 R 488222 CDS YP_002735783.1 225854271 7680427 678207..679142 1 NC_012466.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 679142 7680427 SPJ_0701 Streptococcus pneumoniae JJA dihydroorotate dehydrogenase 1A YP_002735783.1 678207 D 488222 CDS YP_002735784.1 225854272 7680364 679176..680213 1 NC_012466.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 680213 holA 7680364 holA Streptococcus pneumoniae JJA DNA polymerase III subunit delta YP_002735784.1 679176 D 488222 CDS YP_002735785.1 225854273 7679903 680386..680991 1 NC_012466.1 identified by match to protein family HMM PF00081; match to protein family HMM PF02777; superoxide dismutase [Mn] (General stress protein 24)(GSP24) 680991 7679903 SPJ_0703 Streptococcus pneumoniae JJA superoxide dismutase [Mn] (General stress protein 24)(GSP24) YP_002735785.1 680386 D 488222 CDS YP_002735786.1 225854274 7678546 681148..681678 1 NC_012466.1 identified by match to protein family HMM PF06265; transcriptional regulator 681678 7678546 SPJ_0704 Streptococcus pneumoniae JJA transcriptional regulator YP_002735786.1 681148 D 488222 CDS YP_002735787.1 225854275 7680262 681699..682601 1 NC_012466.1 identified by match to protein family HMM TIGR00048; radical SAM enzyme, Cfr family 682601 7680262 SPJ_0705 Streptococcus pneumoniae JJA radical SAM enzyme, Cfr family YP_002735787.1 681699 D 488222 CDS YP_002735788.1 225854276 7678970 682601..683083 1 NC_012466.1 identified by match to protein family HMM PF04892; VanZ family protein 683083 7678970 SPJ_0706 Streptococcus pneumoniae JJA VanZ family protein YP_002735788.1 682601 D 488222 CDS YP_002735789.1 225854277 7678908 683085..684626 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 684626 7678908 SPJ_0707 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002735789.1 683085 D 488222 CDS YP_002735790.1 225854278 7680380 complement(684682..685485) 1 NC_012466.1 identified by match to protein family HMM PF00160; peptidyl-prolyl cis-trans isomerase, cyclophilin-type 685485 7680380 SPJ_0708 Streptococcus pneumoniae JJA peptidyl-prolyl cis-trans isomerase, cyclophilin-type YP_002735790.1 684682 R 488222 CDS YP_002735791.1 225854279 7679763 complement(685569..685772) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 685772 7679763 SPJ_0709 Streptococcus pneumoniae JJA hypothetical protein YP_002735791.1 685569 R 488222 CDS YP_002735792.1 225854280 7680333 complement(685724..685900) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 685900 7680333 SPJ_0710 Streptococcus pneumoniae JJA hypothetical protein YP_002735792.1 685724 R 488222 CDS YP_002735793.1 225854281 7678930 complement(686261..686470) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 686470 7678930 SPJ_0711 Streptococcus pneumoniae JJA hypothetical protein YP_002735793.1 686261 R 488222 CDS YP_002735794.1 225854282 7679382 686640..686912 1 NC_012466.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 686912 rpsP 7679382 rpsP Streptococcus pneumoniae JJA 30S ribosomal protein S16 YP_002735794.1 686640 D 488222 CDS YP_002735795.1 225854283 7679547 686932..687171 1 NC_012466.1 hypothetical protein 687171 7679547 SPJ_0713 Streptococcus pneumoniae JJA hypothetical protein YP_002735795.1 686932 D 488222 CDS YP_002735796.1 225854284 7680275 687748..688536 1 NC_012466.1 identified by match to protein family HMM PF00561; hydrolase, alpha/beta fold family, putative 688536 7680275 SPJ_0714 Streptococcus pneumoniae JJA hydrolase, alpha/beta fold family, putative YP_002735796.1 687748 D 488222 CDS YP_002735797.1 225854285 7678615 688567..689085 1 NC_012466.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 689085 rimM 7678615 rimM Streptococcus pneumoniae JJA 16S rRNA-processing protein RimM YP_002735797.1 688567 D 488222 CDS YP_002735798.1 225854286 7678758 689075..689794 1 NC_012466.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 689794 trmD 7678758 trmD Streptococcus pneumoniae JJA tRNA (guanine-N(1)-)-methyltransferase YP_002735798.1 689075 D 488222 CDS YP_002735799.1 225854287 7680371 689806..690144 1 NC_012466.1 identified by match to protein family HMM PF03477; oxygen-sensitive ribonucleoside-triphosphate reductase 690144 7680371 SPJ_0717 Streptococcus pneumoniae JJA oxygen-sensitive ribonucleoside-triphosphate reductase YP_002735799.1 689806 D 488222 CDS YP_002735800.1 225854288 7680006 complement(690175..690495) 1 NC_012466.1 hypothetical protein 690495 7680006 SPJ_0718 Streptococcus pneumoniae JJA hypothetical protein YP_002735800.1 690175 R 488222 CDS YP_002735801.1 225854289 7680464 690593..690808 1 NC_012466.1 hypothetical protein 690808 7680464 SPJ_0720 Streptococcus pneumoniae JJA hypothetical protein YP_002735801.1 690593 D 488222 CDS YP_002735802.1 225854290 7679186 complement(690805..690951) 1 NC_012466.1 chlorohydrolase 690951 7679186 SPJ_0719 Streptococcus pneumoniae JJA chlorohydrolase YP_002735802.1 690805 R 488222 CDS YP_002735803.1 225854291 7679534 complement(691014..691550) 1 NC_012466.1 identified by match to protein family HMM PF02632; biotin synthase 691550 7679534 SPJ_0721 Streptococcus pneumoniae JJA biotin synthase YP_002735803.1 691014 R 488222 CDS YP_002735804.1 225854292 7679757 691976..692314 1 NC_012466.1 hypothetical protein 692314 7679757 SPJ_0722 Streptococcus pneumoniae JJA hypothetical protein YP_002735804.1 691976 D 488222 CDS YP_002735805.1 225854293 7679014 692380..694362 1 NC_012466.1 antimicrobial peptide ABC transporter permease 694362 7679014 SPJ_0723 Streptococcus pneumoniae JJA antimicrobial peptide ABC transporter permease YP_002735805.1 692380 D 488222 CDS YP_002735806.1 225854294 7678516 694359..694982 1 NC_012466.1 identified by match to protein family HMM PF00005; methionine import ATP-binding protein MetN 694982 7678516 SPJ_0724 Streptococcus pneumoniae JJA methionine import ATP-binding protein MetN YP_002735806.1 694359 D 488222 CDS YP_002735807.1 225854295 7679971 694979..695479 1 NC_012466.1 hypothetical protein 695479 7679971 SPJ_0725 Streptococcus pneumoniae JJA hypothetical protein YP_002735807.1 694979 D 488222 CDS YP_002735808.1 225854296 7679223 complement(695645..696991) 1 NC_012466.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 696991 gor 7679223 gor Streptococcus pneumoniae JJA glutathione reductase YP_002735808.1 695645 R 488222 CDS YP_002735809.1 225854297 7678726 697256..698455 1 NC_012466.1 identified by match to protein family HMM TIGR01730; membrane-fusion protein 698455 7678726 SPJ_0727 Streptococcus pneumoniae JJA membrane-fusion protein YP_002735809.1 697256 D 488222 CDS YP_002735810.1 225854298 7680242 698439..699140 1 NC_012466.1 identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease protein MacB 699140 7680242 SPJ_0728 Streptococcus pneumoniae JJA macrolide export ATP-binding/permease protein MacB YP_002735810.1 698439 D 488222 CDS YP_002735811.1 225854299 7679659 699142..700401 1 NC_012466.1 identified by match to protein family HMM PF02687; antimicrobial peptide ABC transporter permease 700401 7679659 SPJ_0729 Streptococcus pneumoniae JJA antimicrobial peptide ABC transporter permease YP_002735811.1 699142 D 488222 CDS YP_002735812.1 225854300 7678471 700525..702522 1 NC_012466.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 702522 metG 7678471 metG Streptococcus pneumoniae JJA methionyl-tRNA synthetase YP_002735812.1 700525 D 488222 CDS YP_002735813.1 225854301 7679173 702572..702715 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 702715 7679173 SPJ_0731 Streptococcus pneumoniae JJA hypothetical protein YP_002735813.1 702572 D 488222 CDS YP_002735814.1 225854302 7680546 702853..703173 1 NC_012466.1 identified by match to protein family HMM PF03551; transcriptional regulator, PadR family 703173 7680546 SPJ_0732 Streptococcus pneumoniae JJA transcriptional regulator, PadR family YP_002735814.1 702853 D 488222 CDS YP_002735815.1 225854303 7680107 703177..703992 1 NC_012466.1 hypothetical protein 703992 7680107 SPJ_0733 Streptococcus pneumoniae JJA hypothetical protein YP_002735815.1 703177 D 488222 CDS YP_002735816.1 225854304 7680253 703982..704095 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 704095 7680253 SPJ_0734 Streptococcus pneumoniae JJA hypothetical protein YP_002735816.1 703982 D 488222 CDS YP_002735817.1 225854305 7679639 704067..704993 1 NC_012466.1 identified by match to protein family HMM PF00248; oxidoreductase, aldo/keto reductase family 704993 7679639 SPJ_0735 Streptococcus pneumoniae JJA oxidoreductase, aldo/keto reductase family YP_002735817.1 704067 D 488222 CDS YP_002735818.1 225854306 7679325 705089..705325 1 NC_012466.1 hypothetical protein 705325 7679325 SPJ_0736 Streptococcus pneumoniae JJA hypothetical protein YP_002735818.1 705089 D 488222 CDS YP_002735819.1 225854307 7678703 705318..706016 1 NC_012466.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 706016 fabG 7678703 fabG Streptococcus pneumoniae JJA 3-ketoacyl-ACP reductase YP_002735819.1 705318 D 488222 CDS YP_002735820.1 225854308 7678858 706027..706506 1 NC_012466.1 identified by match to protein family HMM PF00293; MutT/nudix family protein 706506 7678858 SPJ_0738 Streptococcus pneumoniae JJA MutT/nudix family protein YP_002735820.1 706027 D 488222 CDS YP_002735821.1 225854309 7680378 706514..707242 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 707242 7680378 SPJ_0739 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002735821.1 706514 D 488222 CDS YP_002735822.1 225854310 7678550 707284..708153 1 NC_012466.1 identified by match to protein family HMM PF02896; PEP-utilizing enzyme family protein 708153 7678550 SPJ_0740 Streptococcus pneumoniae JJA PEP-utilizing enzyme family protein YP_002735822.1 707284 D 488222 CDS YP_002735823.1 225854311 7680117 708128..708568 1 NC_012466.1 identified by match to protein family HMM PF06171; hypothetical protein 708568 7680117 SPJ_0741 Streptococcus pneumoniae JJA hypothetical protein YP_002735823.1 708128 D 488222 CDS YP_002735824.1 225854312 7680392 708691..711237 1 NC_012466.1 identified by match to protein family HMM PF01433; aminopeptidase N 711237 7680392 SPJ_0742 Streptococcus pneumoniae JJA aminopeptidase N YP_002735824.1 708691 D 488222 CDS YP_002735825.1 225854313 7679778 complement(711295..712551) 1 NC_012466.1 identified by match to protein family HMM PF01610; transposase 712551 7679778 SPJ_0743 Streptococcus pneumoniae JJA transposase YP_002735825.1 711295 R 488222 CDS YP_002735826.1 225854314 7678580 712769..713443 1 NC_012466.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; transcriptional regulatory protein CiaR 713443 7678580 SPJ_0744 Streptococcus pneumoniae JJA transcriptional regulatory protein CiaR YP_002735826.1 712769 D 488222 CDS YP_002735827.1 225854315 7680439 713433..714767 1 NC_012466.1 identified by match to protein family HMM PF00512; match to protein family HMM PF02518; sensor protein CiaH 714767 7680439 SPJ_0745 Streptococcus pneumoniae JJA sensor protein CiaH YP_002735827.1 713433 D 488222 CDS YP_002735828.1 225854316 7678940 complement(714801..715088) 1 NC_012466.1 hypothetical protein 715088 7678940 SPJ_0746 Streptococcus pneumoniae JJA hypothetical protein YP_002735828.1 714801 R 488222 CDS YP_002735829.1 225854317 7678507 715228..716157 1 NC_012466.1 identified by match to protein family HMM PF01136; protease 716157 7678507 SPJ_0747 Streptococcus pneumoniae JJA protease YP_002735829.1 715228 D 488222 CDS YP_002735830.1 225854318 7680214 716357..718807 1 NC_012466.1 unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 718807 7680214 SPJ_0748 Streptococcus pneumoniae JJA bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon YP_002735830.1 716357 D 488222 CDS YP_002735831.1 225854319 7679723 718844..720067 1 NC_012466.1 identified by match to protein family HMM PF01098; RodA 720067 7679723 SPJ_0749 Streptococcus pneumoniae JJA RodA YP_002735831.1 718844 D 488222 CDS YP_002735832.1 225854320 7678702 720078..720632 1 NC_012466.1 identified by match to protein family HMM PF01965; match to protein family HMM TIGR01383; 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein 720632 7678702 SPJ_0750 Streptococcus pneumoniae JJA 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein YP_002735832.1 720078 D 488222 CDS YP_002735833.1 225854321 7680453 720717..721280 1 NC_012466.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; phosphoglycolate phosphatase 721280 7680453 SPJ_0751 Streptococcus pneumoniae JJA phosphoglycolate phosphatase YP_002735833.1 720717 D 488222 CDS YP_002735834.1 225854322 7679023 721295..723241 1 NC_012466.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 723241 gyrB 7679023 gyrB Streptococcus pneumoniae JJA DNA gyrase subunit B YP_002735834.1 721295 D 488222 CDS YP_002735835.1 225854323 7678961 723323..725050 1 NC_012466.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 725050 ezrA 7678961 ezrA Streptococcus pneumoniae JJA septation ring formation regulator EzrA YP_002735835.1 723323 D 488222 CDS YP_002735836.1 225854324 7680076 complement(725779..726102) 1 NC_012466.1 identified by match to protein family HMM PF05717; IS66 family element, Orf2 726102 7680076 SPJ_0754 Streptococcus pneumoniae JJA IS66 family element, Orf2 YP_002735836.1 725779 R 488222 CDS YP_002735837.1 225854325 7679571 complement(726363..726662) 1 NC_012466.1 identified by match to protein family HMM PF08860; hypothetical protein 726662 7679571 SPJ_0755 Streptococcus pneumoniae JJA hypothetical protein YP_002735837.1 726363 R 488222 CDS YP_002735838.1 225854326 7679466 727360..727689 1 NC_012466.1 identified by match to protein family HMM PF01710; transposase 727689 7679466 SPJ_0757 Streptococcus pneumoniae JJA transposase YP_002735838.1 727360 D 488222 CDS YP_002735839.1 225854327 7679340 728024..728206 1 NC_012466.1 Spn1, transposase Orf2 728206 7679340 SPJ_0758 Streptococcus pneumoniae JJA Spn1, transposase Orf2 YP_002735839.1 728024 D 488222 CDS YP_002735840.1 225854328 7678555 complement(728413..730671) 1 NC_012466.1 identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; negative regulator of genetic competence ClpC/mecB 730671 7678555 SPJ_0759 Streptococcus pneumoniae JJA negative regulator of genetic competence ClpC/mecB YP_002735840.1 728413 R 488222 CDS YP_002735841.1 225854329 7680293 complement(730900..731130) 1 NC_012466.1 identified by match to protein family HMM PF08796; hypothetical protein 731130 7680293 SPJ_0760 Streptococcus pneumoniae JJA hypothetical protein YP_002735841.1 730900 R 488222 CDS YP_002735842.1 225854330 7679695 731320..732003 1 NC_012466.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 732003 7679695 SPJ_0761 Streptococcus pneumoniae JJA amino acid ABC transporter permease YP_002735842.1 731320 D 488222 CDS YP_002735843.1 225854331 7679748 732003..732737 1 NC_012466.1 identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 732737 7679748 SPJ_0762 Streptococcus pneumoniae JJA glutamine transport ATP-binding protein GlnQ YP_002735843.1 732003 D 488222 CDS YP_002735844.1 225854332 7678981 732870..733748 1 NC_012466.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 733748 7678981 SPJ_0763 Streptococcus pneumoniae JJA bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_002735844.1 732870 D 488222 CDS YP_002735845.1 225854333 7678823 733885..734706 1 NC_012466.1 ABC-type phosphate transport system, ATPase component 734706 7678823 SPJ_0764 Streptococcus pneumoniae JJA ABC-type phosphate transport system, ATPase component YP_002735845.1 733885 D 488222 CDS YP_002735846.1 225854334 7680147 734720..735559 1 NC_012466.1 identified by match to protein family HMM PF01256; match to protein family HMM TIGR00196; putative YjeF homolog, C-terminus 735559 7680147 SPJ_0765 Streptococcus pneumoniae JJA putative YjeF homolog, C-terminus YP_002735846.1 734720 D 488222 CDS YP_002735847.1 225854335 7679444 735857..736540 1 NC_012466.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 736540 rpiA 7679444 rpiA Streptococcus pneumoniae JJA ribose-5-phosphate isomerase A YP_002735847.1 735857 D 488222 CDS YP_002735848.1 225854336 7678832 736554..737765 1 NC_012466.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 737765 deoB 7678832 deoB Streptococcus pneumoniae JJA phosphopentomutase YP_002735848.1 736554 D 488222 CDS YP_002735849.1 225854337 7680409 737767..738177 1 NC_012466.1 identified by match to protein family HMM PF08002; hypothetical protein 738177 7680409 SPJ_0768 Streptococcus pneumoniae JJA hypothetical protein YP_002735849.1 737767 D 488222 CDS YP_002735850.1 225854338 7679795 738324..739133 1 NC_012466.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 739133 7679795 SPJ_0769 Streptococcus pneumoniae JJA purine nucleoside phosphorylase YP_002735850.1 738324 D 488222 CDS YP_002735851.1 225854339 7678573 739609..740004 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 740004 7678573 SPJ_0770 Streptococcus pneumoniae JJA hypothetical protein YP_002735851.1 739609 D 488222 CDS YP_002735852.1 225854340 7679164 740014..740589 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 740589 7679164 SPJ_0771 Streptococcus pneumoniae JJA hypothetical protein YP_002735852.1 740014 D 488222 CDS YP_002735853.1 225854341 7679486 740614..741126 1 NC_012466.1 hemolysin-related protein 741126 7679486 SPJ_0772 Streptococcus pneumoniae JJA hemolysin-related protein YP_002735853.1 740614 D 488222 CDS YP_002735854.1 225854342 7680116 741784..742494 1 NC_012466.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 742494 deoD 7680116 deoD Streptococcus pneumoniae JJA purine nucleoside phosphorylase YP_002735854.1 741784 D 488222 CDS YP_002735855.1 225854343 7679775 complement(742517..743041) 1 NC_012466.1 topology modulation protein 743041 7679775 SPJ_0774 Streptococcus pneumoniae JJA topology modulation protein YP_002735855.1 742517 R 488222 CDS YP_002735856.1 225854344 7680336 complement(743094..743330) 1 NC_012466.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 743330 rpsT 7680336 rpsT Streptococcus pneumoniae JJA 30S ribosomal protein S20 YP_002735856.1 743094 R 488222 CDS YP_002735857.1 225854345 7678565 complement(743398..744318) 1 NC_012466.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 744318 coaA 7678565 coaA Streptococcus pneumoniae JJA pantothenate kinase YP_002735857.1 743398 R 488222 CDS YP_002735858.1 225854346 7679077 744508..744744 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 744744 7679077 SPJ_0777 Streptococcus pneumoniae JJA hypothetical protein YP_002735858.1 744508 D 488222 CDS YP_002735859.1 225854347 7680043 745127..745708 1 NC_012466.1 identified by match to protein family HMM PF05175; methyltransferase small domain superfamily 745708 7680043 SPJ_0778 Streptococcus pneumoniae JJA methyltransferase small domain superfamily YP_002735859.1 745127 D 488222 CDS YP_002735860.1 225854348 7678561 745705..746982 1 NC_012466.1 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 746982 7678561 SPJ_0779 Streptococcus pneumoniae JJA pyrimidine-nucleoside phosphorylase YP_002735860.1 745705 D 488222 CDS YP_002735861.1 225854349 7679888 747000..747662 1 NC_012466.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 747662 deoC 7679888 deoC Streptococcus pneumoniae JJA deoxyribose-phosphate aldolase YP_002735861.1 747000 D 488222 CDS YP_002735862.1 225854350 7678614 747649..748038 1 NC_012466.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 748038 cdd 7678614 cdd Streptococcus pneumoniae JJA cytidine deaminase YP_002735862.1 747649 D 488222 CDS YP_002735863.1 225854351 7678916 748129..749181 1 NC_012466.1 identified by match to protein family HMM PF02608; lipoprotein 749181 7678916 SPJ_0782 Streptococcus pneumoniae JJA lipoprotein YP_002735863.1 748129 D 488222 CDS YP_002735864.1 225854352 7679409 749325..750860 1 NC_012466.1 identified by match to protein family HMM PF00005; ribose import ATP-binding protein RbsA 750860 7679409 SPJ_0783 Streptococcus pneumoniae JJA ribose import ATP-binding protein RbsA YP_002735864.1 749325 D 488222 CDS YP_002735865.1 225854353 7679570 750853..751911 1 NC_012466.1 identified by match to protein family HMM PF02653; ribose/galactose ABC transporter permease 751911 7679570 SPJ_0784 Streptococcus pneumoniae JJA ribose/galactose ABC transporter permease YP_002735865.1 750853 D 488222 CDS YP_002735866.1 225854354 7680055 751914..752870 1 NC_012466.1 identified by match to protein family HMM PF02653; ribose/galactose ABC transporter permease 752870 7680055 SPJ_0785 Streptococcus pneumoniae JJA ribose/galactose ABC transporter permease YP_002735866.1 751914 D 488222 CDS YP_002735867.1 225854355 7679605 752955..753167 1 NC_012466.1 transposase 753167 7679605 SPJ_0786 Streptococcus pneumoniae JJA transposase YP_002735867.1 752955 D 488222 CDS YP_002735868.1 225854356 7680089 753304..753471 1 NC_012466.1 hypothetical protein 753471 7680089 SPJ_0787 Streptococcus pneumoniae JJA hypothetical protein YP_002735868.1 753304 D 488222 CDS YP_002735869.1 225854357 7678630 753471..754304 1 NC_012466.1 identified by match to protein family HMM PF00665; integrase core domain protein 754304 7678630 SPJ_0788 Streptococcus pneumoniae JJA integrase core domain protein YP_002735869.1 753471 D 488222 CDS YP_002735870.1 225854358 7679107 complement(754347..754988) 1 NC_012466.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 754988 7679107 SPJ_0789 Streptococcus pneumoniae JJA putative glycerol-3-phosphate acyltransferase PlsY YP_002735870.1 754347 R 488222 CDS YP_002735871.1 225854359 7678567 755124..757067 1 NC_012466.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 757067 parE 7678567 parE Streptococcus pneumoniae JJA DNA topoisomerase IV subunit B YP_002735871.1 755124 D 488222 CDS YP_002735872.1 225854360 7680138 757188..757313 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 757313 7680138 SPJ_0791 Streptococcus pneumoniae JJA hypothetical protein YP_002735872.1 757188 D 488222 CDS YP_002735873.1 225854361 7679523 757478..759958 1 NC_012466.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 759958 parC 7679523 parC Streptococcus pneumoniae JJA DNA topoisomerase IV subunit A YP_002735873.1 757478 D 488222 CDS YP_002735874.1 225854362 7679475 760090..761112 1 NC_012466.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 761112 ilvE 7679475 ilvE Streptococcus pneumoniae JJA branched-chain amino acid aminotransferase YP_002735874.1 760090 D 488222 CDS YP_002735875.1 225854363 7678828 761168..761872 1 NC_012466.1 hypothetical protein 761872 7678828 SPJ_0794 Streptococcus pneumoniae JJA hypothetical protein YP_002735875.1 761168 D 488222 CDS YP_002735876.1 225854364 7680410 761937..762626 1 NC_012466.1 identified by match to protein family HMM PF06149; permease 762626 7680410 SPJ_0795 Streptococcus pneumoniae JJA permease YP_002735876.1 761937 D 488222 CDS YP_002735877.1 225854365 7679167 762623..763546 1 NC_012466.1 identified by match to protein family HMM PF06166; permease 763546 7679167 SPJ_0796 Streptococcus pneumoniae JJA permease YP_002735877.1 762623 D 488222 CDS YP_002735878.1 225854366 7678586 763561..764205 1 NC_012466.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 764205 pcp1 7678586 pcp1 Streptococcus pneumoniae JJA pyrrolidone-carboxylate peptidase YP_002735878.1 763561 D 488222 CDS YP_002735879.1 225854367 7680164 764373..764603 1 NC_012466.1 hypothetical protein 764603 7680164 SPJ_0798 Streptococcus pneumoniae JJA hypothetical protein YP_002735879.1 764373 D 488222 CDS YP_002735880.1 225854368 7680594 764976..766178 1 NC_012466.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 766178 rpsA 7680594 rpsA Streptococcus pneumoniae JJA 30S ribosomal protein S1 YP_002735880.1 764976 D 488222 CDS YP_002735881.1 225854369 7679629 complement(766263..766766) 1 NC_012466.1 transposase 766766 7679629 SPJ_0802 Streptococcus pneumoniae JJA transposase YP_002735881.1 766263 R 488222 CDS YP_002735882.1 225854370 7679273 complement(766763..767050) 1 NC_012466.1 identified by match to protein family HMM PF01610; transposase 767050 7679273 SPJ_0803 Streptococcus pneumoniae JJA transposase YP_002735882.1 766763 R 488222 CDS YP_002735883.1 225854371 7678891 complement(767047..767418) 1 NC_012466.1 transposase 767418 7678891 SPJ_0804 Streptococcus pneumoniae JJA transposase YP_002735883.1 767047 R 488222 CDS YP_002735884.1 225854372 7680443 767758..768255 1 NC_012466.1 GAF domain-containing protein 768255 7680443 SPJ_0805 Streptococcus pneumoniae JJA GAF domain-containing protein YP_002735884.1 767758 D 488222 CDS YP_002735885.1 225854373 7680166 768255..769910 1 NC_012466.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 769910 7680166 SPJ_0806 Streptococcus pneumoniae JJA DNA polymerase III subunits gamma and tau YP_002735885.1 768255 D 488222 CDS YP_002735886.1 225854374 7679537 769938..770132 1 NC_012466.1 hypothetical protein 770132 7679537 SPJ_0807 Streptococcus pneumoniae JJA hypothetical protein YP_002735886.1 769938 D 488222 CDS YP_002735887.1 225854375 7679154 770282..771052 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM TIGR01978; FeS assembly ATPase SufC 771052 sufC 7679154 sufC Streptococcus pneumoniae JJA FeS assembly ATPase SufC YP_002735887.1 770282 D 488222 CDS YP_002735888.1 225854376 7678521 771080..772342 1 NC_012466.1 identified by match to protein family HMM PF01458; match to protein family HMM TIGR01981; FeS assembly protein SufD 772342 sufD 7678521 sufD Streptococcus pneumoniae JJA FeS assembly protein SufD YP_002735888.1 771080 D 488222 CDS YP_002735889.1 225854377 7680448 772353..773579 1 NC_012466.1 identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM TIGR01979; cysteine desulfurase (Selenocysteine lyase) (Selenocysteine reductase) (Selenocysteine beta-lyase) (SCL) 773579 7680448 SPJ_0810 Streptococcus pneumoniae JJA cysteine desulfurase (Selenocysteine lyase) (Selenocysteine reductase) (Selenocysteine beta-lyase) (SCL) YP_002735889.1 772353 D 488222 CDS YP_002735890.1 225854378 7680014 773566..774006 1 NC_012466.1 identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994; SUF system FeS assembly protein, NifU family 774006 7680014 SPJ_0811 Streptococcus pneumoniae JJA SUF system FeS assembly protein, NifU family YP_002735890.1 773566 D 488222 CDS YP_002735891.1 225854379 7679388 774060..775472 1 NC_012466.1 identified by match to protein family HMM PF01458; match to protein family HMM TIGR01980; FeS assembly protein SufB 775472 sufB 7679388 sufB Streptococcus pneumoniae JJA FeS assembly protein SufB YP_002735891.1 774060 D 488222 CDS YP_002735892.1 225854380 7679805 complement(775671..776912) 1 NC_012466.1 identified by match to protein family HMM PF00144; match to protein family HMM PF00768; match to protein family HMM PF07943; penicillin-binding protein 3 776912 7679805 SPJ_0813 Streptococcus pneumoniae JJA penicillin-binding protein 3 YP_002735892.1 775671 R 488222 CDS YP_002735893.1 225854381 7679501 777093..778124 1 NC_012466.1 identified by match to protein family HMM PF01594; membrane protein 778124 7679501 SPJ_0814 Streptococcus pneumoniae JJA membrane protein YP_002735893.1 777093 D 488222 CDS YP_002735894.1 225854382 7680559 779550..780290 1 NC_012466.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; transcriptional repressor of the fructose operon 780290 7680559 SPJ_0816 Streptococcus pneumoniae JJA transcriptional repressor of the fructose operon YP_002735894.1 779550 D 488222 CDS YP_002735895.1 225854383 7678582 780287..781198 1 NC_012466.1 identified by match to protein family HMM PF00294; match to protein family HMM TIGR03168; 1-phosphofructokinase 781198 pfkB 7678582 pfkB Streptococcus pneumoniae JJA 1-phosphofructokinase YP_002735895.1 780287 D 488222 CDS YP_002735896.1 225854384 7679102 781195..783147 1 NC_012466.1 identified by match to protein family HMM PF00359; match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR00848; match to protein family HMM TIGR01427; PTS system, fructose specific IIABC components 783147 7679102 SPJ_0818 Streptococcus pneumoniae JJA PTS system, fructose specific IIABC components YP_002735896.1 781195 D 488222 CDS YP_002735897.1 225854385 7679898 783159..783317 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 783317 7679898 SPJ_0819 Streptococcus pneumoniae JJA hypothetical protein YP_002735897.1 783159 D 488222 CDS YP_002735898.1 225854386 7680347 783311..785536 1 NC_012466.1 identified by match to protein family HMM PF01580; DNA translocase ftsk 785536 7680347 SPJ_0820 Streptococcus pneumoniae JJA DNA translocase ftsk YP_002735898.1 783311 D 488222 CDS YP_002735899.1 225854387 7679884 complement(785687..786115) 1 NC_012466.1 hypothetical protein 786115 7679884 SPJ_0821 Streptococcus pneumoniae JJA hypothetical protein YP_002735899.1 785687 R 488222 CDS YP_002735900.1 225854388 7680362 786253..787395 1 NC_012466.1 identified by match to protein family HMM PF00266; cysteine desulfurase 787395 7680362 SPJ_0822 Streptococcus pneumoniae JJA cysteine desulfurase YP_002735900.1 786253 D 488222 CDS YP_002735901.1 225854389 7679604 787404..788618 1 NC_012466.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 788618 thiI 7679604 thiI Streptococcus pneumoniae JJA thiamine biosynthesis protein ThiI YP_002735901.1 787404 D 488222 CDS YP_002735902.1 225854390 7679943 788753..789577 1 NC_012466.1 identified by match to protein family HMM PF00756; putative esterase superfamily 789577 7679943 SPJ_0824 Streptococcus pneumoniae JJA putative esterase superfamily YP_002735902.1 788753 D 488222 CDS YP_002735903.1 225854391 7678590 789590..790756 1 NC_012466.1 carbamoylphosphate synthase large subunit 790756 7678590 SPJ_0825 Streptococcus pneumoniae JJA carbamoylphosphate synthase large subunit YP_002735903.1 789590 D 488222 CDS YP_002735904.1 225854392 7678978 791264..792757 1 NC_012466.1 identified by match to protein family HMM PF02384; type I restriction modification enzyme methylase subunit 792757 7678978 SPJ_0826 Streptococcus pneumoniae JJA type I restriction modification enzyme methylase subunit YP_002735904.1 791264 D 488222 CDS YP_002735905.1 225854393 7679936 792770..793786 1 NC_012466.1 identified by match to protein family HMM PF01420; type I restriction-modification enzyme 1, S subunit 793786 7679936 SPJ_0827 Streptococcus pneumoniae JJA type I restriction-modification enzyme 1, S subunit YP_002735905.1 792770 D 488222 CDS YP_002735906.1 225854394 7680522 793783..794370 1 NC_012466.1 identified by match to protein family HMM PF01420; type I restriction enzyme 794370 7680522 SPJ_0828 Streptococcus pneumoniae JJA type I restriction enzyme YP_002735906.1 793783 D 488222 CDS YP_002735907.1 225854395 7679206 794430..794666 1 NC_012466.1 hypothetical protein 794666 7679206 SPJ_0829 Streptococcus pneumoniae JJA hypothetical protein YP_002735907.1 794430 D 488222 CDS YP_002735908.1 225854396 7679249 794663..795076 1 NC_012466.1 identified by match to protein family HMM PF05012; match to protein family HMM TIGR01550; prophage maintenance system killer protein 795076 7679249 SPJ_0830 Streptococcus pneumoniae JJA prophage maintenance system killer protein YP_002735908.1 794663 D 488222 CDS YP_002735909.1 225854397 7679594 795194..796159 1 NC_012466.1 identified by match to protein family HMM PF00589; match to protein family HMM PF02899; integrase/recombinase, phage integrase family 796159 7679594 SPJ_0831 Streptococcus pneumoniae JJA integrase/recombinase, phage integrase family YP_002735909.1 795194 D 488222 CDS YP_002735910.1 225854398 7680075 796125..796763 1 NC_012466.1 identified by match to protein family HMM PF01420; type I restriction-modification enzyme S subunit 796763 7680075 SPJ_0832 Streptococcus pneumoniae JJA type I restriction-modification enzyme S subunit YP_002735910.1 796125 D 488222 CDS YP_002735911.1 225854399 7680523 796793..800143 1 NC_012466.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04313; match to protein family HMM PF04851; type I restriction-modification system R subunit 800143 7680523 SPJ_0833 Streptococcus pneumoniae JJA type I restriction-modification system R subunit YP_002735911.1 796793 D 488222 CDS YP_002735912.1 225854400 7678809 complement(800649..801119) 1 NC_012466.1 identified by match to protein family HMM PF01316; match to protein family HMM PF02863; arginine repressor 801119 7678809 SPJ_0834 Streptococcus pneumoniae JJA arginine repressor YP_002735912.1 800649 R 488222 CDS YP_002735913.1 225854401 7679292 complement(801136..803409) 1 NC_012466.1 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase 803409 7679292 SPJ_0835 Streptococcus pneumoniae JJA x-prolyl-dipeptidyl aminopeptidase YP_002735913.1 801136 R 488222 CDS YP_002735914.1 225854402 7679729 803756..806857 1 NC_012466.1 Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 806857 dnaE 7679729 dnaE Streptococcus pneumoniae JJA DNA polymerase III DnaE YP_002735914.1 803756 D 488222 CDS YP_002735915.1 225854403 7680015 806940..807947 1 NC_012466.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 807947 pfkA 7680015 pfkA Streptococcus pneumoniae JJA 6-phosphofructokinase YP_002735915.1 806940 D 488222 CDS YP_002735916.1 225854404 7679524 808006..809511 1 NC_012466.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 809511 pyk 7679524 pyk Streptococcus pneumoniae JJA pyruvate kinase YP_002735916.1 808006 D 488222 CDS YP_002735917.1 225854405 7679016 811375..812190 1 NC_012466.1 hypothetical protein 812190 7679016 SPJ_0839 Streptococcus pneumoniae JJA hypothetical protein YP_002735917.1 811375 D 488222 CDS YP_002735918.1 225854406 7678461 complement(812297..812680) 1 NC_012466.1 mobile genetic element 812680 7678461 SPJ_0840 Streptococcus pneumoniae JJA mobile genetic element YP_002735918.1 812297 R 488222 CDS YP_002735919.1 225854407 7680416 812823..813104 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 813104 7680416 SPJ_0841 Streptococcus pneumoniae JJA hypothetical protein YP_002735919.1 812823 D 488222 CDS YP_002735920.1 225854408 7679804 813265..813855 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 813855 7679804 SPJ_0842 Streptococcus pneumoniae JJA hypothetical protein YP_002735920.1 813265 D 488222 CDS YP_002735921.1 225854409 7679719 complement(813985..814800) 1 NC_012466.1 identified by match to protein family HMM PF09323; ABC transporter substrate-binding protein 814800 7679719 SPJ_0843 Streptococcus pneumoniae JJA ABC transporter substrate-binding protein YP_002735921.1 813985 R 488222 CDS YP_002735922.1 225854410 7679214 complement(814797..815702) 1 NC_012466.1 identified by match to protein family HMM PF03773; membrane protein 815702 7679214 SPJ_0844 Streptococcus pneumoniae JJA membrane protein YP_002735922.1 814797 R 488222 CDS YP_002735923.1 225854411 7678434 complement(815703..815834) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 815834 7678434 SPJ_0845 Streptococcus pneumoniae JJA hypothetical protein YP_002735923.1 815703 R 488222 CDS YP_002735924.1 225854412 7678796 complement(815948..816133) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 816133 7678796 SPJ_0846 Streptococcus pneumoniae JJA hypothetical protein YP_002735924.1 815948 R 488222 CDS YP_002735925.1 225854413 7680379 816249..818378 1 NC_012466.1 identified by match to protein family HMM PF00575; S1 RNA binding domain protein 818378 7680379 SPJ_0847 Streptococcus pneumoniae JJA S1 RNA binding domain protein YP_002735925.1 816249 D 488222 CDS YP_002735926.1 225854414 7679891 818365..818814 1 NC_012466.1 identified by match to protein family HMM PF03926; hypothetical protein 818814 7679891 SPJ_0848 Streptococcus pneumoniae JJA hypothetical protein YP_002735926.1 818365 D 488222 CDS YP_002735927.1 225854415 7679191 818909..819145 1 NC_012466.1 identified by match to protein family HMM PF04024; PspC domain family 819145 7679191 SPJ_0849 Streptococcus pneumoniae JJA PspC domain family YP_002735927.1 818909 D 488222 CDS YP_002735928.1 225854416 7678584 complement(819499..819690) 1 NC_012466.1 hypothetical protein 819690 7678584 SPJ_0850 Streptococcus pneumoniae JJA hypothetical protein YP_002735928.1 819499 R 488222 CDS YP_002735929.1 225854417 7679078 820118..820876 1 NC_012466.1 identified by match to protein family HMM PF00005; bacitracin export ATP-binding protein BceA 820876 7679078 SPJ_0851 Streptococcus pneumoniae JJA bacitracin export ATP-binding protein BceA YP_002735929.1 820118 D 488222 CDS YP_002735930.1 225854418 7678437 820878..822866 1 NC_012466.1 identified by match to protein family HMM PF02687; antimicrobial peptide ABC transporter permease 822866 7678437 SPJ_0852 Streptococcus pneumoniae JJA antimicrobial peptide ABC transporter permease YP_002735930.1 820878 D 488222 CDS YP_002735931.1 225854419 7678895 complement(822908..823498) 1 NC_012466.1 identified by match to protein family HMM PF01988; integral membrane protein 823498 7678895 SPJ_0853 Streptococcus pneumoniae JJA integral membrane protein YP_002735931.1 822908 R 488222 CDS YP_002735932.1 225854420 7680303 complement(823578..824453) 1 NC_012466.1 identified by match to protein family HMM PF00665; transposase 824453 7680303 SPJ_0854 Streptococcus pneumoniae JJA transposase YP_002735932.1 823578 R 488222 CDS YP_002735933.1 225854421 7679969 complement(824686..824799) 1 NC_012466.1 hypothetical protein 824799 7679969 SPJ_0855 Streptococcus pneumoniae JJA hypothetical protein YP_002735933.1 824686 R 488222 CDS YP_002735934.1 225854422 7679030 825160..826635 1 NC_012466.1 identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM PF01276; match to protein family HMM PF03711; arginine decarboxylase 826635 7679030 SPJ_0857 Streptococcus pneumoniae JJA arginine decarboxylase YP_002735934.1 825160 D 488222 CDS YP_002735935.1 225854423 7678617 complement(826601..827071) 1 NC_012466.1 pilin gene inverting-related protein 827071 7678617 SPJ_0856 Streptococcus pneumoniae JJA pilin gene inverting-related protein YP_002735935.1 826601 R 488222 CDS YP_002735936.1 225854424 7679096 complement(827194..827316) 1 NC_012466.1 transposase 827316 7679096 SPJ_0858 Streptococcus pneumoniae JJA transposase YP_002735936.1 827194 R 488222 CDS YP_002735937.1 225854425 7680069 827572..828432 1 NC_012466.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 828432 speE 7680069 speE Streptococcus pneumoniae JJA spermidine synthase YP_002735937.1 827572 D 488222 CDS YP_002735938.1 225854426 7679603 828429..829688 1 NC_012466.1 identified by match to protein family HMM PF03435; saccharopine dehydrogenase 829688 lys 7679603 lys Streptococcus pneumoniae JJA saccharopine dehydrogenase YP_002735938.1 828429 D 488222 CDS YP_002735939.1 225854427 7680545 829688..830815 1 NC_012466.1 identified by match to protein family HMM PF00278; match to protein family HMM TIGR01047; carboxynorspermidine decarboxylase 830815 nspC 7680545 nspC Streptococcus pneumoniae JJA carboxynorspermidine decarboxylase YP_002735939.1 829688 D 488222 CDS YP_002735940.1 225854428 7679896 830812..831897 1 NC_012466.1 catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis; agmatine deiminase 831897 aguA 7679896 aguA Streptococcus pneumoniae JJA agmatine deiminase YP_002735940.1 830812 D 488222 CDS YP_002735941.1 225854429 7680118 831907..832782 1 NC_012466.1 identified by match to protein family HMM PF00795; match to protein family HMM TIGR03381; N-carbamoylputrescine amidase 832782 aguB 7680118 aguB Streptococcus pneumoniae JJA N-carbamoylputrescine amidase YP_002735941.1 831907 D 488222 CDS YP_002735942.1 225854430 7678931 complement(832963..833772) 1 NC_012466.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 833772 7678931 SPJ_0864 Streptococcus pneumoniae JJA Cof family protein YP_002735942.1 832963 R 488222 CDS YP_002735943.1 225854431 7679142 834044..834265 1 NC_012466.1 hypothetical protein 834265 7679142 SPJ_0865 Streptococcus pneumoniae JJA hypothetical protein YP_002735943.1 834044 D 488222 CDS YP_002735944.1 225854432 7679484 834319..834990 1 NC_012466.1 identified by match to protein family HMM PF02517; caax amino protease family 834990 7679484 SPJ_0866 Streptococcus pneumoniae JJA caax amino protease family YP_002735944.1 834319 D 488222 CDS YP_002735945.1 225854433 7679263 835232..836140 1 NC_012466.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; LysR family transcriptional regulator 836140 7679263 SPJ_0867 Streptococcus pneumoniae JJA LysR family transcriptional regulator YP_002735945.1 835232 D 488222 CDS YP_002735946.1 225854434 7679645 836137..836598 1 NC_012466.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 836598 lspA 7679645 lspA Streptococcus pneumoniae JJA lipoprotein signal peptidase YP_002735946.1 836137 D 488222 CDS YP_002735947.1 225854435 7680469 836588..837475 1 NC_012466.1 identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase D (rRNA-uridine isomerase D) (rRNA pseudouridylate synthase D) 837475 7680469 SPJ_0869 Streptococcus pneumoniae JJA ribosomal large subunit pseudouridine synthase D (rRNA-uridine isomerase D) (rRNA pseudouridylate synthase D) YP_002735947.1 836588 D 488222 CDS YP_002735948.1 225854436 7678783 837478..839361 1 NC_012466.1 identified by match to protein family HMM PF00753; match to protein family HMM PF01473; choline binding protein E 839361 7678783 SPJ_0870 Streptococcus pneumoniae JJA choline binding protein E YP_002735948.1 837478 D 488222 CDS YP_002735949.1 225854437 7678911 839462..840571 1 NC_012466.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 840571 proB 7678911 proB Streptococcus pneumoniae JJA gamma-glutamyl kinase YP_002735949.1 839462 D 488222 CDS YP_002735950.1 225854438 7679422 840581..841843 1 NC_012466.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 841843 proA 7679422 proA Streptococcus pneumoniae JJA gamma-glutamyl phosphate reductase YP_002735950.1 840581 D 488222 CDS YP_002735951.1 225854439 7680221 841847..842644 1 NC_012466.1 identified by match to protein family HMM PF01210; match to protein family HMM PF03446; match to protein family HMM PF03807; match to protein family HMM TIGR00112; pyrroline-5-carboxylate reductase 842644 proC 7680221 proC Streptococcus pneumoniae JJA pyrroline-5-carboxylate reductase YP_002735951.1 841847 D 488222 CDS YP_002735952.1 225854440 7679740 842864..843502 1 NC_012466.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 843502 tmk 7679740 tmk Streptococcus pneumoniae JJA thymidylate kinase YP_002735952.1 842864 D 488222 CDS YP_002735953.1 225854441 7679254 843499..844389 1 NC_012466.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 844389 7679254 SPJ_0875 Streptococcus pneumoniae JJA DNA polymerase III subunit delta' YP_002735953.1 843499 D 488222 CDS YP_002735954.1 225854442 7678764 844429..844746 1 NC_012466.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 844746 7678764 SPJ_0876 Streptococcus pneumoniae JJA DNA replication intiation control protein YabA YP_002735954.1 844429 D 488222 CDS YP_002735955.1 225854443 7678953 844749..845618 1 NC_012466.1 identified by match to protein family HMM PF00590; match to protein family HMM TIGR00096; hypothetical protein 845618 7678953 SPJ_0877 Streptococcus pneumoniae JJA hypothetical protein YP_002735955.1 844749 D 488222 CDS YP_002735956.1 225854444 7679591 845845..846363 1 NC_012466.1 identified by match to protein family HMM PF08020; hypothetical protein 846363 7679591 SPJ_0878 Streptococcus pneumoniae JJA hypothetical protein YP_002735956.1 845845 D 488222 CDS YP_002735957.1 225854445 7678806 846472..847119 1 NC_012466.1 identified by match to protein family HMM PF06970; phage protein 847119 7678806 SPJ_0880 Streptococcus pneumoniae JJA phage protein YP_002735957.1 846472 D 488222 CDS YP_002735958.1 225854446 7678571 complement(847108..847497) 1 NC_012466.1 identified by match to protein family HMM PF01609; transposase (IS4 family) 847497 7678571 SPJ_0879 Streptococcus pneumoniae JJA transposase (IS4 family) YP_002735958.1 847108 R 488222 CDS YP_002735959.1 225854447 7679449 complement(847514..847912) 1 NC_012466.1 mobile genetic element 847912 7679449 SPJ_0881 Streptococcus pneumoniae JJA mobile genetic element YP_002735959.1 847514 R 488222 CDS YP_002735960.1 225854448 7680137 848406..849740 1 NC_012466.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 849740 trmFO 7680137 trmFO Streptococcus pneumoniae JJA tRNA (uracil-5-)-methyltransferase Gid YP_002735960.1 848406 D 488222 CDS YP_002735961.1 225854449 7680184 849824..850561 1 NC_012466.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 850561 pyrH 7680184 pyrH Streptococcus pneumoniae JJA uridylate kinase YP_002735961.1 849824 D 488222 CDS YP_002735962.1 225854450 7679708 850570..851127 1 NC_012466.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 851127 frr 7679708 frr Streptococcus pneumoniae JJA ribosome recycling factor YP_002735962.1 850570 D 488222 CDS YP_002735963.1 225854451 7679867 851187..852041 1 NC_012466.1 s1 RNA binding domain protein 852041 7679867 SPJ_0885 Streptococcus pneumoniae JJA s1 RNA binding domain protein YP_002735963.1 851187 D 488222 CDS YP_002735964.1 225854452 7679387 852050..852265 1 NC_012466.1 identified by match to protein family HMM PF06855; hypothetical protein 852265 7679387 SPJ_0886 Streptococcus pneumoniae JJA hypothetical protein YP_002735964.1 852050 D 488222 CDS YP_002735965.1 225854453 7680493 852351..853319 1 NC_012466.1 identified by match to protein family HMM PF02562; PhoH family protein 853319 7680493 SPJ_0888 Streptococcus pneumoniae JJA PhoH family protein YP_002735965.1 852351 D 488222 CDS YP_002735966.1 225854454 7678956 complement(853297..853422) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 853422 7678956 SPJ_0887 Streptococcus pneumoniae JJA hypothetical protein YP_002735966.1 853297 R 488222 CDS YP_002735967.1 225854455 7680036 853512..854012 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 854012 7680036 SPJ_0889 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002735967.1 853512 D 488222 CDS YP_002735968.1 225854456 7678551 854015..854242 1 NC_012466.1 TfoX N- domain family protein 854242 7678551 SPJ_0890 Streptococcus pneumoniae JJA TfoX N- domain family protein YP_002735968.1 854015 D 488222 CDS YP_002735969.1 225854457 7678730 855930..856499 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 856499 7678730 SPJ_0894 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002735969.1 855930 D 488222 CDS YP_002735970.1 225854458 7680348 856567..857217 1 NC_012466.1 identified by match to protein family HMM PF00633; match to protein family HMM TIGR00426; match to protein family HMM TIGR01259; competence protein 857217 7680348 SPJ_0895 Streptococcus pneumoniae JJA competence protein YP_002735970.1 856567 D 488222 CDS YP_002735971.1 225854459 7679845 857201..859441 1 NC_012466.1 identified by match to protein family HMM PF03772; match to protein family HMM TIGR00360; match to protein family HMM TIGR00361; DNA internalization-related competence protein ComEC/Rec2 859441 7679845 SPJ_0896 Streptococcus pneumoniae JJA DNA internalization-related competence protein ComEC/Rec2 YP_002735971.1 857201 D 488222 CDS YP_002735972.1 225854460 7679024 859841..860428 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 860428 7679024 SPJ_0897 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002735972.1 859841 D 488222 CDS YP_002735973.1 225854461 7678548 860432..861616 1 NC_012466.1 hypothetical protein 861616 7678548 SPJ_0898 Streptococcus pneumoniae JJA hypothetical protein YP_002735973.1 860432 D 488222 CDS YP_002735974.1 225854462 7680026 complement(861622..861771) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 861771 7680026 SPJ_0899 Streptococcus pneumoniae JJA hypothetical protein YP_002735974.1 861622 R 488222 CDS YP_002735975.1 225854463 7679541 861900..862457 1 NC_012466.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 862457 infC 7679541 infC Streptococcus pneumoniae JJA translation initiation factor IF-3 YP_002735975.1 861900 D 488222 CDS YP_002735976.1 225854464 7678777 862490..862690 1 NC_012466.1 identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001; 50S ribosomal protein L35 862690 rpmI 7678777 rpmI Streptococcus pneumoniae JJA 50S ribosomal protein L35 YP_002735976.1 862490 D 488222 CDS YP_002735977.1 225854465 7680477 862742..863101 1 NC_012466.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 863101 rplT 7680477 rplT Streptococcus pneumoniae JJA 50S ribosomal protein L20 YP_002735977.1 862742 D 488222 CDS YP_002735978.1 225854466 7679840 863159..863539 1 NC_012466.1 identified by match to protein family HMM PF00903; lactoylglutathione lyase 863539 7679840 SPJ_0903 Streptococcus pneumoniae JJA lactoylglutathione lyase YP_002735978.1 863159 D 488222 CDS YP_002735979.1 225854467 7680300 863789..864589 1 NC_012466.1 responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+); dihydroorotate dehydrogenase electron transfer subunit 864589 7680300 SPJ_0904 Streptococcus pneumoniae JJA dihydroorotate dehydrogenase electron transfer subunit YP_002735979.1 863789 D 488222 CDS YP_002735980.1 225854468 7678830 864600..865538 1 NC_012466.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 865538 7678830 SPJ_0905 Streptococcus pneumoniae JJA dihydroorotate dehydrogenase 1B YP_002735980.1 864600 D 488222 CDS YP_002735981.1 225854469 7679346 865637..867613 1 NC_012466.1 identified by match to protein family HMM PF01473; match to protein family HMM PF01832; endo-beta-N-acetylglucosaminidase 867613 7679346 SPJ_0906 Streptococcus pneumoniae JJA endo-beta-N-acetylglucosaminidase YP_002735981.1 865637 D 488222 CDS YP_002735982.1 225854470 7679364 complement(867674..869329) 1 NC_012466.1 identified by match to protein family HMM PF05670; match to protein family HMM PF05833; fibronectin/fibrinogen binding protein 869329 7679364 SPJ_0907 Streptococcus pneumoniae JJA fibronectin/fibrinogen binding protein YP_002735982.1 867674 R 488222 CDS YP_002735983.1 225854471 7679977 869434..869931 1 NC_012466.1 identified by match to protein family HMM PF02130; match to protein family HMM TIGR00043; putative metalloprotease 869931 7679977 SPJ_0908 Streptococcus pneumoniae JJA putative metalloprotease YP_002735983.1 869434 D 488222 CDS YP_002735984.1 225854472 7678420 869912..870307 1 NC_012466.1 identified by match to protein family HMM PF01219; diacylglycerol kinase (dagk) (diglyceride kinase)(dgk) 870307 7678420 SPJ_0909 Streptococcus pneumoniae JJA diacylglycerol kinase (dagk) (diglyceride kinase)(dgk) YP_002735984.1 869912 D 488222 CDS YP_002735985.1 225854473 7679017 870324..871223 1 NC_012466.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 871223 era 7679017 era Streptococcus pneumoniae JJA GTP-binding protein Era YP_002735985.1 870324 D 488222 CDS YP_002735986.1 225854474 7679204 871272..872096 1 NC_012466.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 872096 mutM 7679204 mutM Streptococcus pneumoniae JJA formamidopyrimidine-DNA glycosylase YP_002735986.1 871272 D 488222 CDS YP_002735987.1 225854475 7679495 872096..872701 1 NC_012466.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 872701 coaE 7679495 coaE Streptococcus pneumoniae JJA dephospho-CoA kinase YP_002735987.1 872096 D 488222 CDS YP_002735988.1 225854476 7678737 872688..873887 1 NC_012466.1 identified by match to protein family HMM PF07690; multidrug resistance protein MdtG 873887 7678737 SPJ_0913 Streptococcus pneumoniae JJA multidrug resistance protein MdtG YP_002735988.1 872688 D 488222 CDS YP_002735989.1 225854477 7679055 873887..874036 1 NC_012466.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 874036 rpmG 7679055 rpmG Streptococcus pneumoniae JJA 50S ribosomal protein L33 YP_002735989.1 873887 D 488222 CDS YP_002735990.1 225854478 7679354 874076..874309 1 NC_012466.1 identified by match to protein family HMM PF03840; match to protein family HMM TIGR00810; preprotein translocase subunit SecG 874309 secG 7679354 secG Streptococcus pneumoniae JJA preprotein translocase subunit SecG YP_002735990.1 874076 D 488222 CDS YP_002735991.1 225854479 7679712 874411..876765 1 NC_012466.1 identified by match to protein family HMM PF00575; match to protein family HMM PF00773; match to protein family HMM PF08206; match to protein family HMM TIGR00358; match to protein family HMM TIGR02063; ribonuclease R 876765 rnr 7679712 rnr Streptococcus pneumoniae JJA ribonuclease R YP_002735991.1 874411 D 488222 CDS YP_002735992.1 225854480 7679545 876728..877195 1 NC_012466.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 877195 smpB 7679545 smpB Streptococcus pneumoniae JJA SsrA-binding protein YP_002735992.1 876728 D 488222 CDS YP_002735993.1 225854481 7680155 877211..878071 1 NC_012466.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 878071 tehB 7680155 tehB Streptococcus pneumoniae JJA tellurite resistance protein TehB YP_002735993.1 877211 D 488222 CDS YP_002735994.1 225854482 7679365 878144..879097 1 NC_012466.1 identified by match to protein family HMM PF06054; competence protein 879097 7679365 SPJ_0919 Streptococcus pneumoniae JJA competence protein YP_002735994.1 878144 D 488222 CDS YP_002735995.1 225854483 7680029 879116..880918 1 NC_012466.1 identified by match to protein family HMM PF01432; match to protein family HMM PF08439; match to protein family HMM TIGR00181; oligoendopeptidase F 880918 pepF1 7680029 pepF1 Streptococcus pneumoniae JJA oligoendopeptidase F YP_002735995.1 879116 D 488222 CDS YP_002735996.1 225854484 7679389 880956..881633 1 NC_012466.1 identified by match to protein family HMM PF01596; match to protein family HMM PF08241; O-methyltransferase family protein 881633 7679389 SPJ_0921 Streptococcus pneumoniae JJA O-methyltransferase family protein YP_002735996.1 880956 D 488222 CDS YP_002735997.1 225854485 7678924 881700..882641 1 NC_012466.1 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase protein PrsA 882641 prsA 7678924 prsA Streptococcus pneumoniae JJA foldase protein PrsA YP_002735997.1 881700 D 488222 CDS YP_002735998.1 225854486 7679726 complement(882758..883099) 1 NC_012466.1 hypothetical protein 883099 7679726 SPJ_0923 Streptococcus pneumoniae JJA hypothetical protein YP_002735998.1 882758 R 488222 CDS YP_002735999.1 225854487 7678852 complement(883099..883233) 1 NC_012466.1 transposase 883233 7678852 SPJ_0924 Streptococcus pneumoniae JJA transposase YP_002735999.1 883099 R 488222 CDS YP_002736000.1 225854488 7679070 complement(883886..884506) 1 NC_012466.1 identified by match to protein family HMM PF00300; phosphoglycerate mutase 884506 7679070 SPJ_0925 Streptococcus pneumoniae JJA phosphoglycerate mutase YP_002736000.1 883886 R 488222 CDS YP_002736001.1 225854489 7679700 complement(884506..884988) 1 NC_012466.1 identified by match to protein family HMM PF04073; regulatory protein 884988 7679700 SPJ_0926 Streptococcus pneumoniae JJA regulatory protein YP_002736001.1 884506 R 488222 CDS YP_002736002.1 225854490 7679811 complement(884988..885830) 1 NC_012466.1 identified by match to protein family HMM PF04018; integral membrane protein 885830 7679811 SPJ_0927 Streptococcus pneumoniae JJA integral membrane protein YP_002736002.1 884988 R 488222 CDS YP_002736003.1 225854491 7680388 complement(885925..886725) 1 NC_012466.1 identified by match to protein family HMM PF01183; lyzozyme M1 886725 7680388 SPJ_0928 Streptococcus pneumoniae JJA lyzozyme M1 YP_002736003.1 885925 R 488222 CDS YP_002736004.1 225854492 7678698 886869..888248 1 NC_012466.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 888248 glmU 7678698 glmU Streptococcus pneumoniae JJA bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_002736004.1 886869 D 488222 CDS YP_002736005.1 225854493 7679372 888258..888803 1 NC_012466.1 identified by match to protein family HMM PF00293; ADP-ribose pyrophosphatase 888803 7679372 SPJ_0930 Streptococcus pneumoniae JJA ADP-ribose pyrophosphatase YP_002736005.1 888258 D 488222 CDS YP_002736006.1 225854494 7678863 888815..889129 1 NC_012466.1 hypothetical protein 889129 7678863 SPJ_0931 Streptococcus pneumoniae JJA hypothetical protein YP_002736006.1 888815 D 488222 CDS YP_002736007.1 225854495 7679367 889146..889838 1 NC_012466.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 889838 mtnN 7679367 mtnN Streptococcus pneumoniae JJA 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_002736007.1 889146 D 488222 CDS YP_002736008.1 225854496 7679585 889927..890406 1 NC_012466.1 identified by match to protein family HMM PF04394; hypothetical protein 890406 7679585 SPJ_0933 Streptococcus pneumoniae JJA hypothetical protein YP_002736008.1 889927 D 488222 CDS YP_002736009.1 225854497 7679018 890504..891094 1 NC_012466.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 891094 7679018 SPJ_0934 Streptococcus pneumoniae JJA DNA polymerase III subunit epsilon YP_002736009.1 890504 D 488222 CDS YP_002736010.1 225854498 7680012 891103..892866 1 NC_012466.1 identified by match to protein family HMM PF03009; glycerophosphoryl diester phosphodiesterase family protein 892866 7680012 SPJ_0935 Streptococcus pneumoniae JJA glycerophosphoryl diester phosphodiesterase family protein YP_002736010.1 891103 D 488222 CDS YP_002736011.1 225854499 7680351 893080..893409 1 NC_012466.1 identified by match to protein family HMM PF01710; Spn1 transposase 893409 7680351 SPJ_0936 Streptococcus pneumoniae JJA Spn1 transposase YP_002736011.1 893080 D 488222 CDS YP_002736012.1 225854500 7678428 893588..893728 1 NC_012466.1 hypothetical protein 893728 7678428 SPJ_0937 Streptococcus pneumoniae JJA hypothetical protein YP_002736012.1 893588 D 488222 CDS YP_002736013.1 225854501 7679008 893889..894089 1 NC_012466.1 hypothetical protein 894089 7679008 SPJ_0938 Streptococcus pneumoniae JJA hypothetical protein YP_002736013.1 893889 D 488222 CDS YP_002736014.1 225854502 7679929 894131..894535 1 NC_012466.1 hypothetical protein 894535 7679929 SPJ_0939 Streptococcus pneumoniae JJA hypothetical protein YP_002736014.1 894131 D 488222 CDS YP_002736015.1 225854503 7680513 894766..895473 1 NC_012466.1 identified by match to protein family HMM PF02683; cytochrome c-type biogenesis protein CcdA 895473 7680513 SPJ_0940 Streptococcus pneumoniae JJA cytochrome c-type biogenesis protein CcdA YP_002736015.1 894766 D 488222 CDS YP_002736016.1 225854504 7680526 895484..896041 1 NC_012466.1 identified by match to protein family HMM PF00578; match to protein family HMM PF08534; thioredoxin family protein 896041 7680526 SPJ_0941 Streptococcus pneumoniae JJA thioredoxin family protein YP_002736016.1 895484 D 488222 CDS YP_002736017.1 225854505 7679032 896415..897806 1 NC_012466.1 identified by match to protein family HMM PF00324; amino acid permease family protein 897806 7679032 SPJ_0942 Streptococcus pneumoniae JJA amino acid permease family protein YP_002736017.1 896415 D 488222 CDS YP_002736018.1 225854506 7679527 897949..898866 1 NC_012466.1 identified by match to protein family HMM PF01297; zinc-binding lipoprotein AdcA 898866 7679527 SPJ_0943 Streptococcus pneumoniae JJA zinc-binding lipoprotein AdcA YP_002736018.1 897949 D 488222 CDS YP_002736019.1 225854507 7680434 898874..901390 1 NC_012466.1 identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein B 901390 7680434 SPJ_0944 Streptococcus pneumoniae JJA pneumococcal histidine triad protein B YP_002736019.1 898874 D 488222 CDS YP_002736020.1 225854508 7679983 901600..904719 1 NC_012466.1 identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein E 904719 7679983 SPJ_0945 Streptococcus pneumoniae JJA pneumococcal histidine triad protein E YP_002736020.1 901600 D 488222 CDS YP_002736021.1 225854509 7679231 905880..906119 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 906119 7679231 SPJ_0946 Streptococcus pneumoniae JJA hypothetical protein YP_002736021.1 905880 D 488222 CDS YP_002736022.1 225854510 7679282 906414..907043 1 NC_012466.1 hypothetical protein 907043 7679282 SPJ_0947 Streptococcus pneumoniae JJA hypothetical protein YP_002736022.1 906414 D 488222 CDS YP_002736023.1 225854511 7678667 complement(907079..908302) 1 NC_012466.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 908302 pepT 7678667 pepT Streptococcus pneumoniae JJA peptidase T YP_002736023.1 907079 R 488222 CDS YP_002736024.1 225854512 7680521 908457..909551 1 NC_012466.1 identified by match to protein family HMM PF00762; match to protein family HMM TIGR00109; ferrochelatase 909551 hemH 7680521 hemH Streptococcus pneumoniae JJA ferrochelatase YP_002736024.1 908457 D 488222 CDS YP_002736025.1 225854513 7680141 complement(909593..909970) 1 NC_012466.1 identified by match to protein family HMM PF01741; match to protein family HMM TIGR00220; large conductance mechanosensitive channel protein 909970 mscL 7680141 mscL Streptococcus pneumoniae JJA large conductance mechanosensitive channel protein YP_002736025.1 909593 R 488222 CDS YP_002736026.1 225854514 7679193 complement(910052..910483) 1 NC_012466.1 identified by match to protein family HMM PF04138; MesH protein 910483 7679193 SPJ_0951 Streptococcus pneumoniae JJA MesH protein YP_002736026.1 910052 R 488222 CDS YP_002736027.1 225854515 7678483 910606..911115 1 NC_012466.1 identified by match to protein family HMM PF06177; citrulline cluster-linked protein 911115 7678483 SPJ_0952 Streptococcus pneumoniae JJA citrulline cluster-linked protein YP_002736027.1 910606 D 488222 CDS YP_002736028.1 225854516 7680557 911918..912994 1 NC_012466.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 912994 asd 7680557 asd Streptococcus pneumoniae JJA aspartate-semialdehyde dehydrogenase YP_002736028.1 911918 D 488222 CDS YP_002736029.1 225854517 7679844 913050..913985 1 NC_012466.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 913985 dapA 7679844 dapA Streptococcus pneumoniae JJA dihydrodipicolinate synthase YP_002736029.1 913050 D 488222 CDS YP_002736030.1 225854518 7679497 complement(914032..915405) 1 NC_012466.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 915405 trmE 7679497 trmE Streptococcus pneumoniae JJA tRNA modification GTPase TrmE YP_002736030.1 914032 R 488222 CDS YP_002736031.1 225854519 7680252 complement(915541..915723) 1 NC_012466.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 915723 7680252 SPJ_0957 Streptococcus pneumoniae JJA 4-oxalocrotonate tautomerase YP_002736031.1 915541 R 488222 CDS YP_002736032.1 225854520 7678700 915846..916436 1 NC_012466.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 916436 tdk 7678700 tdk Streptococcus pneumoniae JJA thymidine kinase YP_002736032.1 915846 D 488222 CDS YP_002736033.1 225854521 7679342 916433..917512 1 NC_012466.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 917512 prfA 7679342 prfA Streptococcus pneumoniae JJA peptide chain release factor 1 YP_002736033.1 916433 D 488222 CDS YP_002736034.1 225854522 7679925 917512..918351 1 NC_012466.1 identified by match to protein family HMM PF05175; match to protein family HMM PF08241; match to protein family HMM PF08242; match to protein family HMM TIGR00536; match to protein family HMM TIGR03387; protein-(glutamine-N5) methyltransferase, release factor-specific 918351 hemK 7679925 hemK Streptococcus pneumoniae JJA protein-(glutamine-N5) methyltransferase, release factor-specific YP_002736034.1 917512 D 488222 CDS YP_002736035.1 225854523 7680500 918335..918937 1 NC_012466.1 identified by match to protein family HMM PF01300; match to protein family HMM TIGR00057; Sua5/YciO/YrdC/YwlC family protein 918937 7680500 SPJ_0961 Streptococcus pneumoniae JJA Sua5/YciO/YrdC/YwlC family protein YP_002736035.1 918335 D 488222 CDS YP_002736036.1 225854524 7679183 918939..919370 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family protein 919370 7679183 SPJ_0962 Streptococcus pneumoniae JJA acetyltransferase, gnat family protein YP_002736036.1 918939 D 488222 CDS YP_002736037.1 225854525 7679717 919432..920688 1 NC_012466.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 920688 glyA 7679717 glyA Streptococcus pneumoniae JJA serine hydroxymethyltransferase YP_002736037.1 919432 D 488222 CDS YP_002736038.1 225854526 7678714 920696..921670 1 NC_012466.1 hypothetical protein 921670 7678714 SPJ_0964 Streptococcus pneumoniae JJA hypothetical protein YP_002736038.1 920696 D 488222 CDS YP_002736039.1 225854527 7678748 921670..922284 1 NC_012466.1 pneumococcal vaccine antigen A 922284 7678748 SPJ_0965 Streptococcus pneumoniae JJA pneumococcal vaccine antigen A YP_002736039.1 921670 D 488222 CDS YP_002736040.1 225854528 7679630 922358..923332 1 NC_012466.1 identified by match to protein family HMM PF06207; hypothetical protein 923332 7679630 SPJ_0966 Streptococcus pneumoniae JJA hypothetical protein YP_002736040.1 922358 D 488222 CDS YP_002736041.1 225854529 7679143 923406..925037 1 NC_012466.1 identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA 925037 rumA1 7679143 rumA1 Streptococcus pneumoniae JJA 23S rRNA (uracil-5-)-methyltransferase RumA YP_002736041.1 923406 D 488222 CDS YP_002736042.1 225854530 7678993 925775..925993 1 NC_012466.1 hypothetical protein 925993 7678993 SPJ_0968 Streptococcus pneumoniae JJA hypothetical protein YP_002736042.1 925775 D 488222 CDS YP_002736043.1 225854531 7678486 926386..927411 1 NC_012466.1 identified by match to protein family HMM PF01497; ABC transporter substrate-binding protein - iron transport 927411 7678486 SPJ_0969 Streptococcus pneumoniae JJA ABC transporter substrate-binding protein - iron transport YP_002736043.1 926386 D 488222 CDS YP_002736044.1 225854532 7680452 927401..928408 1 NC_012466.1 identified by match to protein family HMM PF01032; iron-compound ABC transporter, permease protein 928408 7680452 SPJ_0970 Streptococcus pneumoniae JJA iron-compound ABC transporter, permease protein YP_002736044.1 927401 D 488222 CDS YP_002736045.1 225854533 7679999 928408..929415 1 NC_012466.1 identified by match to protein family HMM PF01032; Fe3+ ABC transporter permease 929415 7679999 SPJ_0971 Streptococcus pneumoniae JJA Fe3+ ABC transporter permease YP_002736045.1 928408 D 488222 CDS YP_002736046.1 225854534 7680204 929415..930209 1 NC_012466.1 identified by match to protein family HMM PF00005; ferric enterobactin transport ATP-binding protein FepC 930209 7680204 SPJ_0972 Streptococcus pneumoniae JJA ferric enterobactin transport ATP-binding protein FepC YP_002736046.1 929415 D 488222 CDS YP_002736047.1 225854535 7679737 930777..930986 1 NC_012466.1 identified by match to protein family HMM PF07674; hypothetical protein 930986 7679737 SPJ_0973 Streptococcus pneumoniae JJA hypothetical protein YP_002736047.1 930777 D 488222 CDS YP_002736048.1 225854536 7678984 931135..931266 1 NC_012466.1 hypothetical protein 931266 7678984 SPJ_0974 Streptococcus pneumoniae JJA hypothetical protein YP_002736048.1 931135 D 488222 CDS YP_002736049.1 225854537 7678591 931950..932111 1 NC_012466.1 hypothetical protein 932111 7678591 SPJ_0975 Streptococcus pneumoniae JJA hypothetical protein YP_002736049.1 931950 D 488222 CDS YP_002736050.1 225854538 7679580 934150..934716 1 NC_012466.1 hypothetical protein 934716 7679580 SPJ_0978 Streptococcus pneumoniae JJA hypothetical protein YP_002736050.1 934150 D 488222 CDS YP_002736051.1 225854539 7679574 935038..935226 1 NC_012466.1 hypothetical protein 935226 7679574 SPJ_0979 Streptococcus pneumoniae JJA hypothetical protein YP_002736051.1 935038 D 488222 CDS YP_002736052.1 225854540 7680178 935288..936103 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 936103 7680178 SPJ_0980 Streptococcus pneumoniae JJA hypothetical protein YP_002736052.1 935288 D 488222 CDS YP_002736053.1 225854541 7678612 936103..936957 1 NC_012466.1 identified by match to protein family HMM PF03747; ADP-ribosylation/Crystallin J1 936957 7678612 SPJ_0981 Streptococcus pneumoniae JJA ADP-ribosylation/Crystallin J1 YP_002736053.1 936103 D 488222 CDS YP_002736054.1 225854542 7679820 937069..937953 1 NC_012466.1 identified by match to protein family HMM PF00781; match to protein family HMM TIGR00147; hypothetical protein 937953 7679820 SPJ_0982 Streptococcus pneumoniae JJA hypothetical protein YP_002736054.1 937069 D 488222 CDS YP_002736055.1 225854543 7680425 938116..939855 1 NC_012466.1 identified by match to protein family HMM PF00128; match to protein family HMM PF02903; neopullulanase 939855 7680425 SPJ_0983 Streptococcus pneumoniae JJA neopullulanase YP_002736055.1 938116 D 488222 CDS YP_002736056.1 225854544 7678793 939941..940258 1 NC_012466.1 hypothetical protein 940258 7678793 SPJ_0984 Streptococcus pneumoniae JJA hypothetical protein YP_002736056.1 939941 D 488222 CDS YP_002736057.1 225854545 7678505 940463..940585 1 NC_012466.1 hypothetical protein 940585 7678505 SPJ_0985 Streptococcus pneumoniae JJA hypothetical protein YP_002736057.1 940463 D 488222 CDS YP_002736058.1 225854546 7679846 940725..940838 1 NC_012466.1 hypothetical protein 940838 7679846 SPJ_0986 Streptococcus pneumoniae JJA hypothetical protein YP_002736058.1 940725 D 488222 CDS YP_002736059.1 225854547 7679480 941225..941506 1 NC_012466.1 hypothetical protein 941506 7679480 SPJ_0987 Streptococcus pneumoniae JJA hypothetical protein YP_002736059.1 941225 D 488222 CDS YP_002736060.1 225854548 7679907 941506..942267 1 NC_012466.1 identified by match to protein family HMM PF06414; signal recognition particle GTPase 942267 7679907 SPJ_0988 Streptococcus pneumoniae JJA signal recognition particle GTPase YP_002736060.1 941506 D 488222 CDS YP_002736061.1 225854549 7679421 942295..943071 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 943071 7679421 SPJ_0989 Streptococcus pneumoniae JJA hypothetical protein YP_002736061.1 942295 D 488222 CDS YP_002736062.1 225854550 7678397 942999..943451 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 943451 7678397 SPJ_0990 Streptococcus pneumoniae JJA hypothetical protein YP_002736062.1 942999 D 488222 CDS YP_002736063.1 225854551 7680119 944283..944642 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 944642 7680119 SPJ_0991 Streptococcus pneumoniae JJA hypothetical protein YP_002736063.1 944283 D 488222 CDS YP_002736064.1 225854552 7679654 944652..944981 1 NC_012466.1 identified by match to protein family HMM PF05713; putative mobilization protein (MobC) 944981 7679654 SPJ_0992 Streptococcus pneumoniae JJA putative mobilization protein (MobC) YP_002736064.1 944652 D 488222 CDS YP_002736065.1 225854553 7680320 946302..946889 1 NC_012466.1 chromosome segregation ATPase 946889 7680320 SPJ_0995 Streptococcus pneumoniae JJA chromosome segregation ATPase YP_002736065.1 946302 D 488222 CDS YP_002736066.1 225854554 7678479 complement(946934..947788) 1 NC_012466.1 identified by match to protein family HMM TIGR01716; transcriptional regulator 947788 7678479 SPJ_0996 Streptococcus pneumoniae JJA transcriptional regulator YP_002736066.1 946934 R 488222 CDS YP_002736067.1 225854555 7679041 948011..948559 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 948559 7679041 SPJ_0997 Streptococcus pneumoniae JJA hypothetical protein YP_002736067.1 948011 D 488222 CDS YP_002736068.1 225854556 7679975 948552..950675 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF02463; match to protein family HMM PF03412; lantibiotic mersacidin transporter system 950675 7679975 SPJ_0998 Streptococcus pneumoniae JJA lantibiotic mersacidin transporter system YP_002736068.1 948552 D 488222 CDS YP_002736069.1 225854557 7678391 950688..950858 1 NC_012466.1 hypothetical protein 950858 7678391 SPJ_0999 Streptococcus pneumoniae JJA hypothetical protein YP_002736069.1 950688 D 488222 CDS YP_002736070.1 225854558 7678780 950892..951620 1 NC_012466.1 identified by match to protein family HMM PF00005; bacitracin transport ATP-binding protein BcrA 951620 7678780 SPJ_1000 Streptococcus pneumoniae JJA bacitracin transport ATP-binding protein BcrA YP_002736070.1 950892 D 488222 CDS YP_002736071.1 225854559 7679312 951613..952350 1 NC_012466.1 hypothetical protein 952350 7679312 SPJ_1001 Streptococcus pneumoniae JJA hypothetical protein YP_002736071.1 951613 D 488222 CDS YP_002736072.1 225854560 7680282 952363..953073 1 NC_012466.1 hypothetical protein 953073 7680282 SPJ_1002 Streptococcus pneumoniae JJA hypothetical protein YP_002736072.1 952363 D 488222 CDS YP_002736073.1 225854561 7678711 953615..953836 1 NC_012466.1 identified by match to protein family HMM PF01381; hypothetical protein 953836 7678711 SPJ_1004 Streptococcus pneumoniae JJA hypothetical protein YP_002736073.1 953615 D 488222 CDS YP_002736074.1 225854562 7680506 complement(953826..953975) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 953975 7680506 SPJ_1003 Streptococcus pneumoniae JJA hypothetical protein YP_002736074.1 953826 R 488222 CDS YP_002736075.1 225854563 7679039 954734..955963 1 NC_012466.1 identified by match to protein family HMM PF01098; cell division protein FtsW 955963 7679039 SPJ_1005 Streptococcus pneumoniae JJA cell division protein FtsW YP_002736075.1 954734 D 488222 CDS YP_002736076.1 225854564 7680175 955983..958679 1 NC_012466.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 958679 ppc 7680175 ppc Streptococcus pneumoniae JJA phosphoenolpyruvate carboxylase YP_002736076.1 955983 D 488222 CDS YP_002736077.1 225854565 7678443 959092..960096 1 NC_012466.1 identified by match to protein family HMM PF04392; ABC transporter substrate-binding protein 960096 7678443 SPJ_1007 Streptococcus pneumoniae JJA ABC transporter substrate-binding protein YP_002736077.1 959092 D 488222 CDS YP_002736078.1 225854566 7679241 960165..961031 1 NC_012466.1 identified by match to protein family HMM PF02653; ABC transporter 961031 7679241 SPJ_1008 Streptococcus pneumoniae JJA ABC transporter YP_002736078.1 960165 D 488222 CDS YP_002736079.1 225854567 7679710 961028..961786 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 961786 7679710 SPJ_1009 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002736079.1 961028 D 488222 CDS YP_002736080.1 225854568 7680442 961876..963636 1 NC_012466.1 synthesizes RNA primers at the replication forks; DNA primase 963636 dnaG 7680442 dnaG Streptococcus pneumoniae JJA DNA primase YP_002736080.1 961876 D 488222 CDS YP_002736081.1 225854569 7679126 963639..964748 1 NC_012466.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 964748 7679126 SPJ_1011 Streptococcus pneumoniae JJA RNA polymerase sigma factor RpoD YP_002736081.1 963639 D 488222 CDS YP_002736082.1 225854570 7678441 964762..965091 1 NC_012466.1 identified by match to protein family HMM PF01883; N-6 Adenine-specific DNA methylase YitW 965091 7678441 SPJ_1012 Streptococcus pneumoniae JJA N-6 Adenine-specific DNA methylase YitW YP_002736082.1 964762 D 488222 CDS YP_002736083.1 225854571 7680037 965206..966249 1 NC_012466.1 identified by match to protein family HMM PF00534; glycosyl transferase CpoA 966249 7680037 SPJ_1013 Streptococcus pneumoniae JJA glycosyl transferase CpoA YP_002736083.1 965206 D 488222 CDS YP_002736084.1 225854572 7679637 966265..967590 1 NC_012466.1 identified by match to protein family HMM PF00534; glycosyl transferase, group 1 967590 7679637 SPJ_1014 Streptococcus pneumoniae JJA glycosyl transferase, group 1 YP_002736084.1 966265 D 488222 CDS YP_002736085.1 225854573 7679566 967621..967797 1 NC_012466.1 identified by match to protein family HMM PF04024; hypothetical protein 967797 7679566 SPJ_1015 Streptococcus pneumoniae JJA hypothetical protein YP_002736085.1 967621 D 488222 CDS YP_002736086.1 225854574 7679374 967856..967990 1 NC_012466.1 hypothetical protein 967990 7679374 SPJ_1016 Streptococcus pneumoniae JJA hypothetical protein YP_002736086.1 967856 D 488222 CDS YP_002736087.1 225854575 7678884 968054..969364 1 NC_012466.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 969364 obgE 7678884 obgE Streptococcus pneumoniae JJA GTPase ObgE YP_002736087.1 968054 D 488222 CDS YP_002736088.1 225854576 7678638 969374..969532 1 NC_012466.1 hypothetical protein 969532 7678638 SPJ_1018 Streptococcus pneumoniae JJA hypothetical protein YP_002736088.1 969374 D 488222 CDS YP_002736089.1 225854577 7679800 970619..971878 1 NC_012466.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 971878 murA1 7679800 murA1 Streptococcus pneumoniae JJA UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002736089.1 970619 D 488222 CDS YP_002736090.1 225854578 7678860 971894..972445 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 972445 7678860 SPJ_1020 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002736090.1 971894 D 488222 CDS YP_002736091.1 225854579 7680039 972438..973715 1 NC_012466.1 identified by match to protein family HMM PF00571; match to protein family HMM PF07085; match to protein family HMM PF08279; cytosolic protein containing multiple CBS domains 973715 7680039 SPJ_1021 Streptococcus pneumoniae JJA cytosolic protein containing multiple CBS domains YP_002736091.1 972438 D 488222 CDS YP_002736092.1 225854580 7679798 973731..974591 1 NC_012466.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 974591 map 7679798 map Streptococcus pneumoniae JJA methionine aminopeptidase YP_002736092.1 973731 D 488222 CDS YP_002736093.1 225854581 7679308 974690..975232 1 NC_012466.1 transposase 975232 7679308 SPJ_1023 Streptococcus pneumoniae JJA transposase YP_002736093.1 974690 D 488222 CDS YP_002736094.1 225854582 7679125 975385..975774 1 NC_012466.1 identified by match to protein family HMM PF01609; transposase (IS4 family) 975774 7679125 SPJ_1024 Streptococcus pneumoniae JJA transposase (IS4 family) YP_002736094.1 975385 D 488222 CDS YP_002736095.1 225854583 7679261 975965..978256 1 NC_012466.1 identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073; ATP-dependent DNA helicase PcrA 978256 pcrA 7679261 pcrA Streptococcus pneumoniae JJA ATP-dependent DNA helicase PcrA YP_002736095.1 975965 D 488222 CDS YP_002736096.1 225854584 7680296 978299..978979 1 NC_012466.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 978979 radC 7680296 radC Streptococcus pneumoniae JJA DNA repair protein RadC YP_002736096.1 978299 D 488222 CDS YP_002736097.1 225854585 7678470 complement(978976..979665) 1 NC_012466.1 identified by match to protein family HMM PF00117; match to protein family HMM PF07722; glutamine amidotransferase, class I 979665 7678470 SPJ_1026 Streptococcus pneumoniae JJA glutamine amidotransferase, class I YP_002736097.1 978976 R 488222 CDS YP_002736098.1 225854586 7678459 complement(979683..980324) 1 NC_012466.1 modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex 980324 7678459 SPJ_1028 Streptococcus pneumoniae JJA redox-sensing transcriptional repressor Rex YP_002736098.1 979683 R 488222 CDS YP_002736099.1 225854587 7678994 complement(980407..980622) 1 NC_012466.1 hypothetical protein 980622 7678994 SPJ_1029 Streptococcus pneumoniae JJA hypothetical protein YP_002736099.1 980407 R 488222 CDS YP_002736100.1 225854588 7680004 complement(980630..980977) 1 NC_012466.1 identified by match to protein family HMM PF08866; hypothetical protein 980977 7680004 SPJ_1030 Streptococcus pneumoniae JJA hypothetical protein YP_002736100.1 980630 R 488222 CDS YP_002736101.1 225854589 7680490 complement(980982..982097) 1 NC_012466.1 identified by match to protein family HMM PF00266; putative cysteine desulfurase (NifS protein homolog) 982097 7680490 SPJ_1031 Streptococcus pneumoniae JJA putative cysteine desulfurase (NifS protein homolog) YP_002736101.1 980982 R 488222 CDS YP_002736102.1 225854590 7678779 complement(982107..983066) 1 NC_012466.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 983066 7678779 SPJ_1032 Streptococcus pneumoniae JJA ribose-phosphate pyrophosphokinase YP_002736102.1 982107 R 488222 CDS YP_002736103.1 225854591 7679455 complement(983179..983748) 1 NC_012466.1 identified by match to protein family HMM PF01928; adenylate cyclase 983748 7679455 SPJ_1033 Streptococcus pneumoniae JJA adenylate cyclase YP_002736103.1 983179 R 488222 CDS YP_002736104.1 225854592 7679998 983876..984547 1 NC_012466.1 identified by match to protein family HMM PF04607; GTP pyrophosphokinase 984547 7679998 SPJ_1034 Streptococcus pneumoniae JJA GTP pyrophosphokinase YP_002736104.1 983876 D 488222 CDS YP_002736105.1 225854593 7679217 984531..985349 1 NC_012466.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 985349 ppnK 7679217 ppnK Streptococcus pneumoniae JJA inorganic polyphosphate/ATP-NAD kinase YP_002736105.1 984531 D 488222 CDS YP_002736106.1 225854594 7680316 985346..986242 1 NC_012466.1 identified by match to protein family HMM PF00849; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase, RluD subfamily 986242 7680316 SPJ_1036 Streptococcus pneumoniae JJA ribosomal large subunit pseudouridine synthase, RluD subfamily YP_002736106.1 985346 D 488222 CDS YP_002736107.1 225854595 7678605 986286..987260 1 NC_012466.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 987260 eutD 7678605 eutD Streptococcus pneumoniae JJA phosphotransacetylase YP_002736107.1 986286 D 488222 CDS YP_002736108.1 225854596 7679037 complement(987521..987907) 1 NC_012466.1 transposase 987907 7679037 SPJ_1038 Streptococcus pneumoniae JJA transposase YP_002736108.1 987521 R 488222 CDS YP_002736109.1 225854597 7679511 complement(988045..988332) 1 NC_012466.1 identified by match to protein family HMM PF01610; transposase 988332 7679511 SPJ_1039 Streptococcus pneumoniae JJA transposase YP_002736109.1 988045 R 488222 CDS YP_002736110.1 225854598 7679698 complement(988329..988700) 1 NC_012466.1 transposase 988700 7679698 SPJ_1040 Streptococcus pneumoniae JJA transposase YP_002736110.1 988329 R 488222 CDS YP_002736111.1 225854599 7680173 complement(989029..989328) 1 NC_012466.1 identified by match to protein family HMM PF02575; match to protein family HMM TIGR00103; hypothetical protein 989328 7680173 SPJ_1041 Streptococcus pneumoniae JJA hypothetical protein YP_002736111.1 989029 R 488222 CDS YP_002736112.1 225854600 7680505 989730..990434 1 NC_012466.1 identified by match to protein family HMM PF06912; hypothetical protein 990434 7680505 SPJ_1042 Streptococcus pneumoniae JJA hypothetical protein YP_002736112.1 989730 D 488222 CDS YP_002736113.1 225854601 7680064 990616..990930 1 NC_012466.1 identified by match to protein family HMM PF00829; match to protein family HMM TIGR00061; 50S ribosomal protein L21 990930 rplU 7680064 rplU Streptococcus pneumoniae JJA 50S ribosomal protein L21 YP_002736113.1 990616 D 488222 CDS YP_002736114.1 225854602 7680027 990946..991290 1 NC_012466.1 identified by match to protein family HMM PF04327; hypothetical protein 991290 7680027 SPJ_1044 Streptococcus pneumoniae JJA hypothetical protein YP_002736114.1 990946 D 488222 CDS YP_002736115.1 225854603 7680151 991307..991600 1 NC_012466.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 991600 rpmA 7680151 rpmA Streptococcus pneumoniae JJA 50S ribosomal protein L27 YP_002736115.1 991307 D 488222 CDS YP_002736116.1 225854604 7679642 complement(991946..992116) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 992116 7679642 SPJ_1046 Streptococcus pneumoniae JJA hypothetical protein YP_002736116.1 991946 R 488222 CDS YP_002736117.1 225854605 7679465 complement(992088..992216) 1 NC_012466.1 hypothetical protein 992216 7679465 SPJ_1047 Streptococcus pneumoniae JJA hypothetical protein YP_002736117.1 992088 R 488222 CDS YP_002736118.1 225854606 7678419 992553..993470 1 NC_012466.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 993470 ribF 7678419 ribF Streptococcus pneumoniae JJA bifunctional riboflavin kinase/FMN adenylyltransferase YP_002736118.1 992553 D 488222 CDS YP_002736119.1 225854607 7680304 complement(993563..994411) 1 NC_012466.1 identified by match to protein family HMM PF02588; hypothetical protein 994411 7680304 SPJ_1049 Streptococcus pneumoniae JJA hypothetical protein YP_002736119.1 993563 R 488222 CDS YP_002736120.1 225854608 7679854 994553..995392 1 NC_012466.1 identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; hypothetical protein 995392 7679854 SPJ_1050 Streptococcus pneumoniae JJA hypothetical protein YP_002736120.1 994553 D 488222 CDS YP_002736121.1 225854609 7678693 995499..995774 1 NC_012466.1 identified by match to protein family HMM PF00216; DNA-binding protein HU 1 (DNA-binding protein II) (HB) 995774 7678693 SPJ_1051 Streptococcus pneumoniae JJA DNA-binding protein HU 1 (DNA-binding protein II) (HB) YP_002736121.1 995499 D 488222 CDS YP_002736122.1 225854610 7679329 996204..998105 1 NC_012466.1 identified by match to protein family HMM PF00005; ATPase component of ABC transporter with duplicated ATPase domains 998105 7679329 SPJ_1052 Streptococcus pneumoniae JJA ATPase component of ABC transporter with duplicated ATPase domains YP_002736122.1 996204 D 488222 CDS YP_002736123.1 225854611 7679556 998108..998971 1 NC_012466.1 identified by match to protein family HMM TIGR01716; transcriptional regulator 998971 7679556 SPJ_1053 Streptococcus pneumoniae JJA transcriptional regulator YP_002736123.1 998108 D 488222 CDS YP_002736124.1 225854612 7680441 999051..1000229 1 NC_012466.1 identified by match to protein family HMM PF07690; macrolide ABC transporter permease 1000229 7680441 SPJ_1054 Streptococcus pneumoniae JJA macrolide ABC transporter permease YP_002736124.1 999051 D 488222 CDS YP_002736125.1 225854613 7678955 1000322..1002280 1 NC_012466.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1002280 ligA 7678955 ligA Streptococcus pneumoniae JJA NAD-dependent DNA ligase LigA YP_002736125.1 1000322 D 488222 CDS YP_002736126.1 225854614 7678463 1002392..1004671 1 NC_012466.1 identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02104; pullulanase, type I 1004671 pulA 7678463 pulA Streptococcus pneumoniae JJA pullulanase, type I YP_002736126.1 1002392 D 488222 CDS YP_002736127.1 225854615 7679866 1005216..1006640 1 NC_012466.1 identified by match to protein family HMM PF00171; NADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1006640 7679866 SPJ_1057 Streptococcus pneumoniae JJA NADP-dependent glyceraldehyde-3-phosphate dehydrogenase YP_002736127.1 1005216 D 488222 CDS YP_002736128.1 225854616 7679439 1007123..1009051 1 NC_012466.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 1009051 glgB 7679439 glgB Streptococcus pneumoniae JJA glycogen branching enzyme YP_002736128.1 1007123 D 488222 CDS YP_002736129.1 225854617 7679331 1009041..1010183 1 NC_012466.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1010183 glgC 7679331 glgC Streptococcus pneumoniae JJA glucose-1-phosphate adenylyltransferase YP_002736129.1 1009041 D 488222 CDS YP_002736130.1 225854618 7678862 1010173..1011312 1 NC_012466.1 identified by match to protein family HMM PF00483; match to protein family HMM TIGR02092; glucose-1-phosphate adenylyltransferase, GlgD subunit 1011312 glgD 7678862 glgD Streptococcus pneumoniae JJA glucose-1-phosphate adenylyltransferase, GlgD subunit YP_002736130.1 1010173 D 488222 CDS YP_002736131.1 225854619 7680299 1011309..1012742 1 NC_012466.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 1012742 glgA 7680299 glgA Streptococcus pneumoniae JJA glycogen synthase YP_002736131.1 1011309 D 488222 CDS YP_002736132.1 225854620 7679538 1013455..1014258 1 NC_012466.1 identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase 1014258 7679538 SPJ_1065 Streptococcus pneumoniae JJA glycerate kinase YP_002736132.1 1013455 D 488222 CDS YP_002736133.1 225854621 7679392 complement(1014255..1014701) 1 NC_012466.1 identified by match to protein family HMM PF07997; hypothetical protein 1014701 7679392 SPJ_1064 Streptococcus pneumoniae JJA hypothetical protein YP_002736133.1 1014255 R 488222 CDS YP_002736134.1 225854622 7678881 1014865..1016169 1 NC_012466.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1016169 eno 7678881 eno Streptococcus pneumoniae JJA phosphopyruvate hydratase YP_002736134.1 1014865 D 488222 CDS YP_002736135.1 225854623 7679771 complement(1016307..1016687) 1 NC_012466.1 identified by match to protein family HMM PF00589; integrase/recombinase, phage integrase family protein 1016687 7679771 SPJ_1067 Streptococcus pneumoniae JJA integrase/recombinase, phage integrase family protein YP_002736135.1 1016307 R 488222 CDS YP_002736136.1 225854624 7679691 complement(1016653..1016835) 1 NC_012466.1 transposase 1016835 7679691 SPJ_1068 Streptococcus pneumoniae JJA transposase YP_002736136.1 1016653 R 488222 CDS YP_002736137.1 225854625 7680279 complement(1017136..1017486) 1 NC_012466.1 identified by match to protein family HMM PF01710; transposase 1017486 7680279 SPJ_1069 Streptococcus pneumoniae JJA transposase YP_002736137.1 1017136 R 488222 CDS YP_002736138.1 225854626 7678421 1018012..1021287 1 NC_012466.1 identified by match to protein family HMM TIGR02774; ATP-dependent nuclease subunit B 1021287 rexB 7678421 rexB Streptococcus pneumoniae JJA ATP-dependent nuclease subunit B YP_002736138.1 1018012 D 488222 CDS YP_002736139.1 225854627 7679029 1021284..1024934 1 NC_012466.1 identified by match to protein family HMM PF00580; match to protein family HMM TIGR02785; recombination helicase AddA 1024934 addA 7679029 addA Streptococcus pneumoniae JJA recombination helicase AddA YP_002736139.1 1021284 D 488222 CDS YP_002736140.1 225854628 7680017 1025149..1026327 1 NC_012466.1 hypothetical protein 1026327 7680017 SPJ_1072 Streptococcus pneumoniae JJA hypothetical protein YP_002736140.1 1025149 D 488222 CDS YP_002736141.1 225854629 7680391 1026536..1033015 1 NC_012466.1 identified by match to protein family HMM PF00089; match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM PF07581; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; IgA1 protease 1033015 7680391 SPJ_1073 Streptococcus pneumoniae JJA IgA1 protease YP_002736141.1 1026536 D 488222 CDS YP_002736142.1 225854630 7678686 1033059..1038272 1 NC_012466.1 identified by match to protein family HMM PF00746; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM TIGR01167; zinc metalloprotease ZmpB 1038272 zmpB3 7678686 zmpB3 Streptococcus pneumoniae JJA zinc metalloprotease ZmpB YP_002736142.1 1033059 D 488222 CDS YP_002736143.1 225854631 7680433 1038526..1039377 1 NC_012466.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1039377 rbgA 7680433 rbgA Streptococcus pneumoniae JJA ribosomal biogenesis GTPase YP_002736143.1 1038526 D 488222 CDS YP_002736144.1 225854632 7679810 1039364..1040143 1 NC_012466.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1040143 rnhB 7679810 rnhB Streptococcus pneumoniae JJA ribonuclease HII YP_002736144.1 1039364 D 488222 CDS YP_002736145.1 225854633 7679187 1040159..1041709 1 NC_012466.1 identified by match to protein family HMM PF00654; match to protein family HMM PF02080; voltage-gated chloride channel family protein 1041709 7679187 SPJ_1077 Streptococcus pneumoniae JJA voltage-gated chloride channel family protein YP_002736145.1 1040159 D 488222 CDS YP_002736146.1 225854634 7680402 1042293..1043363 1 NC_012466.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1043363 xerS 7680402 xerS Streptococcus pneumoniae JJA site-specific tyrosine recombinase XerS YP_002736146.1 1042293 D 488222 CDS YP_002736147.1 225854635 7678804 complement(1043436..1044425) 1 NC_012466.1 identified by match to protein family HMM PF03099; match to protein family HMM TIGR00545; lipoate protein ligase A 1044425 7678804 SPJ_1079 Streptococcus pneumoniae JJA lipoate protein ligase A YP_002736147.1 1043436 R 488222 CDS YP_002736148.1 225854636 7679445 complement(1044489..1046192) 1 NC_012466.1 identified by match to protein family HMM PF00070; match to protein family HMM PF00364; match to protein family HMM PF01134; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350; dihydrolipoyl dehydrogenase 1046192 lpdA 7679445 lpdA Streptococcus pneumoniae JJA dihydrolipoyl dehydrogenase YP_002736148.1 1044489 R 488222 CDS YP_002736149.1 225854637 7680142 complement(1046238..1047281) 1 NC_012466.1 unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain; dihydrolipoamide acetyltransferase 1047281 7680142 SPJ_1081 Streptococcus pneumoniae JJA dihydrolipoamide acetyltransferase YP_002736149.1 1046238 R 488222 CDS YP_002736150.1 225854638 7678578 complement(1047499..1048491) 1 NC_012466.1 identified by match to protein family HMM PF02779; match to protein family HMM PF02780; pyruvate dehydrogenase E1 component subunit beta 1048491 7678578 SPJ_1082 Streptococcus pneumoniae JJA pyruvate dehydrogenase E1 component subunit beta YP_002736150.1 1047499 R 488222 CDS YP_002736151.1 225854639 7679166 complement(1048507..1049475) 1 NC_012466.1 identified by match to protein family HMM PF00676; pyruvate dehydrogenase E1 component subunit alpha 1049475 7679166 SPJ_1083 Streptococcus pneumoniae JJA pyruvate dehydrogenase E1 component subunit alpha YP_002736151.1 1048507 R 488222 CDS YP_002736152.1 225854640 7679649 complement(1049629..1050990) 1 NC_012466.1 identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; mate efflux family protein 1050990 7679649 SPJ_1084 Streptococcus pneumoniae JJA mate efflux family protein YP_002736152.1 1049629 R 488222 CDS YP_002736153.1 225854641 7679116 complement(1051275..1052543) 1 NC_012466.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1052543 pyrC 7679116 pyrC Streptococcus pneumoniae JJA dihydroorotase YP_002736153.1 1051275 R 488222 CDS YP_002736154.1 225854642 7679478 complement(1052556..1053020) 1 NC_012466.1 identified by match to protein family HMM PF00293; mutator MutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase) 1053020 7679478 SPJ_1086 Streptococcus pneumoniae JJA mutator MutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase) YP_002736154.1 1052556 R 488222 CDS YP_002736155.1 225854643 7680091 complement(1053030..1053683) 1 NC_012466.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 1053683 ung 7680091 ung Streptococcus pneumoniae JJA uracil-DNA glycosylase YP_002736155.1 1053030 R 488222 CDS YP_002736156.1 225854644 7678792 complement(1053821..1054012) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1054012 7678792 SPJ_1088 Streptococcus pneumoniae JJA hypothetical protein YP_002736156.1 1053821 R 488222 CDS YP_002736157.1 225854645 7679425 complement(1054019..1054423) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1054423 7679425 SPJ_1089 Streptococcus pneumoniae JJA hypothetical protein YP_002736157.1 1054019 R 488222 CDS YP_002736158.1 225854646 7679814 complement(1054481..1055194) 1 NC_012466.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; match to protein family HMM TIGR02254; HAD superfamily (subfamily IA) hydrolase 1055194 7679814 SPJ_1090 Streptococcus pneumoniae JJA HAD superfamily (subfamily IA) hydrolase YP_002736158.1 1054481 R 488222 CDS YP_002736159.1 225854647 7680073 complement(1056449..1059037) 1 NC_012466.1 identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein B 1059037 7680073 SPJ_1093 Streptococcus pneumoniae JJA pneumococcal histidine triad protein B YP_002736159.1 1056449 R 488222 CDS YP_002736160.1 225854648 7679085 1059158..1059295 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1059295 7679085 SPJ_1095 Streptococcus pneumoniae JJA hypothetical protein YP_002736160.1 1059158 D 488222 CDS YP_002736161.1 225854649 7678747 complement(1059292..1061025) 1 NC_012466.1 identified by match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR01417; phosphoenolpyruvate-protein phosphotransferase 1061025 ptsP 7678747 ptsP Streptococcus pneumoniae JJA phosphoenolpyruvate-protein phosphotransferase YP_002736161.1 1059292 R 488222 CDS YP_002736162.1 225854650 7680251 complement(1061031..1061294) 1 NC_012466.1 identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; phosphocarrier protein HPr 1061294 7680251 SPJ_1096 Streptococcus pneumoniae JJA phosphocarrier protein HPr YP_002736162.1 1061031 R 488222 CDS YP_002736163.1 225854651 7679222 1061645..1061863 1 NC_012466.1 identified by match to protein family HMM PF00462; match to protein family HMM TIGR02194; glutaredoxin 1061863 7679222 SPJ_1097 Streptococcus pneumoniae JJA glutaredoxin YP_002736163.1 1061645 D 488222 CDS YP_002736164.1 225854652 7680007 1061944..1064103 1 NC_012466.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1064103 7680007 SPJ_1098 Streptococcus pneumoniae JJA ribonucleotide-diphosphate reductase subunit alpha YP_002736164.1 1061944 D 488222 CDS YP_002736165.1 225854653 7680143 1064291..1065253 1 NC_012466.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1065253 nrdF 7680143 nrdF Streptococcus pneumoniae JJA ribonucleotide-diphosphate reductase subunit beta YP_002736165.1 1064291 D 488222 CDS YP_002736166.1 225854654 7680343 1065541..1066302 1 NC_012466.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; lactose phosphotransferase system repressor 1066302 7680343 SPJ_1100 Streptococcus pneumoniae JJA lactose phosphotransferase system repressor YP_002736166.1 1065541 D 488222 CDS YP_002736167.1 225854655 7679728 complement(1066581..1066760) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1066760 7679728 SPJ_1101 Streptococcus pneumoniae JJA hypothetical protein YP_002736167.1 1066581 R 488222 CDS YP_002736168.1 225854656 7679257 complement(1066883..1068289) 1 NC_012466.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 1068289 lacG 7679257 lacG Streptococcus pneumoniae JJA 6-phospho-beta-galactosidase YP_002736168.1 1066883 R 488222 CDS YP_002736169.1 225854657 7678767 complement(1068504..1070198) 1 NC_012466.1 identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00394; match to protein family HMM TIGR00410; match to protein family HMM TIGR00853; PTS system, lactose-specific IIC component 1070198 7678767 SPJ_1103 Streptococcus pneumoniae JJA PTS system, lactose-specific IIC component YP_002736169.1 1068504 R 488222 CDS YP_002736170.1 225854658 7680174 complement(1070200..1070517) 1 NC_012466.1 identified by match to protein family HMM PF02255; match to protein family HMM TIGR00823; lactose-specific phosphotransferase enzyme iia component (pts system lactose-specific eiia component) (eiia-lac) (eiii-lac) 1070517 7680174 SPJ_1104 Streptococcus pneumoniae JJA lactose-specific phosphotransferase enzyme iia component (pts system lactose-specific eiia component) (eiia-lac) (eiii-lac) YP_002736170.1 1070200 R 488222 CDS YP_002736171.1 225854659 7678468 complement(1070553..1071389) 1 NC_012466.1 identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator LacT 1071389 7678468 SPJ_1105 Streptococcus pneumoniae JJA transcription antiterminator LacT YP_002736171.1 1070553 R 488222 CDS YP_002736172.1 225854660 7678952 complement(1071623..1072603) 1 NC_012466.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase 1072603 lacD 7678952 lacD Streptococcus pneumoniae JJA tagatose 1,6-diphosphate aldolase YP_002736172.1 1071623 R 488222 CDS YP_002736173.1 225854661 7679693 complement(1072605..1073534) 1 NC_012466.1 catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase 1073534 lacC 7679693 lacC Streptococcus pneumoniae JJA tagatose-6-phosphate kinase YP_002736173.1 1072605 R 488222 CDS YP_002736174.1 225854662 7678624 complement(1073545..1074060) 1 NC_012466.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB 1074060 lacB 7678624 lacB Streptococcus pneumoniae JJA galactose-6-phosphate isomerase subunit LacB YP_002736174.1 1073545 R 488222 CDS YP_002736175.1 225854663 7679099 complement(1074091..1074516) 1 NC_012466.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA 1074516 lacA 7679099 lacA Streptococcus pneumoniae JJA galactose-6-phosphate isomerase subunit LacA YP_002736175.1 1074091 R 488222 CDS YP_002736176.1 225854664 7679850 complement(1074673..1075017) 1 NC_012466.1 hypothetical protein 1075017 7679850 SPJ_1110 Streptococcus pneumoniae JJA hypothetical protein YP_002736176.1 1074673 R 488222 CDS YP_002736177.1 225854665 7680327 complement(1075186..1075584) 1 NC_012466.1 mobile genetic element 1075584 7680327 SPJ_1111 Streptococcus pneumoniae JJA mobile genetic element YP_002736177.1 1075186 R 488222 CDS YP_002736178.1 225854666 7679278 complement(1075515..1075805) 1 NC_012466.1 mobile genetic element 1075805 7679278 SPJ_1112 Streptococcus pneumoniae JJA mobile genetic element YP_002736178.1 1075515 R 488222 CDS YP_002736179.1 225854667 7679967 complement(1075805..1075987) 1 NC_012466.1 mobile genetic element 1075987 7679967 SPJ_1113 Streptococcus pneumoniae JJA mobile genetic element YP_002736179.1 1075805 R 488222 CDS YP_002736180.1 225854668 7679602 complement(1075995..1076297) 1 NC_012466.1 PTS system, galactose-specific IIB component 1076297 7679602 SPJ_1114 Streptococcus pneumoniae JJA PTS system, galactose-specific IIB component YP_002736180.1 1075995 R 488222 CDS YP_002736181.1 225854669 7680257 complement(1076335..1076607) 1 NC_012466.1 phosphotransferase system sugar-specific EII component 1076607 7680257 SPJ_1115 Streptococcus pneumoniae JJA phosphotransferase system sugar-specific EII component YP_002736181.1 1076335 R 488222 CDS YP_002736182.1 225854670 7678545 complement(1076607..1076723) 1 NC_012466.1 phosphotransferase system sugar-specific EII component 1076723 7678545 SPJ_1116 Streptococcus pneumoniae JJA phosphotransferase system sugar-specific EII component YP_002736182.1 1076607 R 488222 CDS YP_002736183.1 225854671 7678974 1076990..1077277 1 NC_012466.1 chlorohydrolase 1077277 7678974 SPJ_1117 Streptococcus pneumoniae JJA chlorohydrolase YP_002736183.1 1076990 D 488222 CDS YP_002736184.1 225854672 7679751 complement(1077358..1079181) 1 NC_012466.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 1079181 lepA 7679751 lepA Streptococcus pneumoniae JJA GTP-binding protein LepA YP_002736184.1 1077358 R 488222 CDS YP_002736185.1 225854673 7678883 complement(1079260..1079988) 1 NC_012466.1 identified by match to protein family HMM PF00149; serine/threonine protein phosphatase 1079988 7678883 SPJ_1119 Streptococcus pneumoniae JJA serine/threonine protein phosphatase YP_002736185.1 1079260 R 488222 CDS YP_002736186.1 225854674 7679377 complement(1079990..1081657) 1 NC_012466.1 identified by match to protein family HMM PF02463; match to protein family HMM TIGR00634; DNA repair protein RecN 1081657 recN 7679377 recN Streptococcus pneumoniae JJA DNA repair protein RecN YP_002736186.1 1079990 R 488222 CDS YP_002736187.1 225854675 7680324 complement(1081664..1082095) 1 NC_012466.1 identified by match to protein family HMM PF01316; match to protein family HMM PF02863; transcriptional regulator of arginine metabolism expression 1082095 7680324 SPJ_1121 Streptococcus pneumoniae JJA transcriptional regulator of arginine metabolism expression YP_002736187.1 1081664 R 488222 CDS YP_002736188.1 225854676 7679838 complement(1082088..1082903) 1 NC_012466.1 identified by match to protein family HMM PF01479; match to protein family HMM PF01728; match to protein family HMM TIGR00478; hemolysin A 1082903 tylA 7679838 tylA Streptococcus pneumoniae JJA hemolysin A YP_002736188.1 1082088 R 488222 CDS YP_002736189.1 225854677 7679682 complement(1082896..1083771) 1 NC_012466.1 identified by match to protein family HMM PF00348; geranyltranstransferase (Farnesyl-diphosphate synthase)(FPP synthase) 1083771 7679682 SPJ_1123 Streptococcus pneumoniae JJA geranyltranstransferase (Farnesyl-diphosphate synthase)(FPP synthase) YP_002736189.1 1082896 R 488222 CDS YP_002736190.1 225854678 7679159 complement(1083768..1083980) 1 NC_012466.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 1083980 xseB 7679159 xseB Streptococcus pneumoniae JJA exodeoxyribonuclease VII small subunit YP_002736190.1 1083768 R 488222 CDS YP_002736191.1 225854679 7679379 complement(1083958..1085298) 1 NC_012466.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 1085298 xseA 7679379 xseA Streptococcus pneumoniae JJA exodeoxyribonuclease VII large subunit YP_002736191.1 1083958 R 488222 CDS YP_002736192.1 225854680 7678869 complement(1085426..1086064) 1 NC_012466.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1086064 udk 7678869 udk Streptococcus pneumoniae JJA uridine kinase YP_002736192.1 1085426 R 488222 CDS YP_002736193.1 225854681 7680061 complement(1086172..1086474) 1 NC_012466.1 hypothetical protein 1086474 7680061 SPJ_1127 Streptococcus pneumoniae JJA hypothetical protein YP_002736193.1 1086172 R 488222 CDS YP_002736194.1 225854682 7679598 complement(1086715..1087593) 1 NC_012466.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1087593 truB 7679598 truB Streptococcus pneumoniae JJA tRNA pseudouridine synthase B YP_002736194.1 1086715 R 488222 CDS YP_002736195.1 225854683 7679750 complement(1087603..1088877) 1 NC_012466.1 hypothetical protein 1088877 7679750 SPJ_1129 Streptococcus pneumoniae JJA hypothetical protein YP_002736195.1 1087603 R 488222 CDS YP_002736196.1 225854684 7678778 complement(1090380..1091177) 1 NC_012466.1 identified by match to protein family HMM PF01226; formate-nitrate transporter 1091177 7678778 SPJ_1132 Streptococcus pneumoniae JJA formate-nitrate transporter YP_002736196.1 1090380 R 488222 CDS YP_002736197.1 225854685 7679430 complement(1091421..1092164) 1 NC_012466.1 identified by match to protein family HMM PF04203; match to protein family HMM TIGR01076; sortase 1092164 7679430 SPJ_1133 Streptococcus pneumoniae JJA sortase YP_002736197.1 1091421 R 488222 CDS YP_002736198.1 225854686 7680153 complement(1092164..1094632) 1 NC_012466.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 1094632 gyrA 7680153 gyrA Streptococcus pneumoniae JJA DNA gyrase subunit A YP_002736198.1 1092164 R 488222 CDS YP_002736199.1 225854687 7679764 1094826..1095812 1 NC_012466.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1095812 ldh 7679764 ldh Streptococcus pneumoniae JJA L-lactate dehydrogenase YP_002736199.1 1094826 D 488222 CDS YP_002736200.1 225854688 7679314 complement(1096161..1096856) 1 NC_012466.1 identified by match to protein family HMM PF00520; match to protein family HMM PF07885; potassium/ion channel protein 1096856 7679314 SPJ_1136 Streptococcus pneumoniae JJA potassium/ion channel protein YP_002736200.1 1096161 R 488222 CDS YP_002736201.1 225854689 7679075 complement(1096903..1097157) 1 NC_012466.1 identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; cytotoxic translational repressor of toxin-antitoxin stability system 1097157 7679075 SPJ_1137 Streptococcus pneumoniae JJA cytotoxic translational repressor of toxin-antitoxin stability system YP_002736201.1 1096903 R 488222 CDS YP_002736202.1 225854690 7678653 complement(1097159..1097401) 1 NC_012466.1 hypothetical protein 1097401 7678653 SPJ_1138 Streptococcus pneumoniae JJA hypothetical protein YP_002736202.1 1097159 R 488222 CDS YP_002736203.1 225854691 7680110 complement(1097492..1098301) 1 NC_012466.1 identified by match to protein family HMM PF00753; VicX protein 1098301 7680110 SPJ_1139 Streptococcus pneumoniae JJA VicX protein YP_002736203.1 1097492 R 488222 CDS YP_002736204.1 225854692 7679554 complement(1098303..1099652) 1 NC_012466.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM TIGR00229; sensor protein YycG 1099652 7679554 SPJ_1140 Streptococcus pneumoniae JJA sensor protein YycG YP_002736204.1 1098303 R 488222 CDS YP_002736205.1 225854693 7679338 complement(1099645..1100349) 1 NC_012466.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; alkaline phosphatase synthesis transcriptional regulatory proteinphoP 1100349 7679338 SPJ_1141 Streptococcus pneumoniae JJA alkaline phosphatase synthesis transcriptional regulatory proteinphoP YP_002736205.1 1099645 R 488222 CDS YP_002736206.1 225854694 7678723 complement(1100404..1101579) 1 NC_012466.1 identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01084; A/G-specific adenine glycosylase 1101579 mutY 7678723 mutY Streptococcus pneumoniae JJA A/G-specific adenine glycosylase YP_002736206.1 1100404 R 488222 CDS YP_002736207.1 225854695 7680473 complement(1101907..1103577) 1 NC_012466.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 1103577 fhs 7680473 fhs Streptococcus pneumoniae JJA formate--tetrahydrofolate ligase YP_002736207.1 1101907 R 488222 CDS YP_002736208.1 225854696 7680028 1103807..1104496 1 NC_012466.1 identified by match to protein family HMM PF04127; match to protein family HMM TIGR02114; phosphopantothenate--cysteine ligase 1104496 coaB 7680028 coaB Streptococcus pneumoniae JJA phosphopantothenate--cysteine ligase YP_002736208.1 1103807 D 488222 CDS YP_002736209.1 225854697 7680200 1104508..1105059 1 NC_012466.1 decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 1105059 coaC 7680200 coaC Streptococcus pneumoniae JJA phosphopantothenoylcysteine decarboxylase YP_002736209.1 1104508 D 488222 CDS YP_002736210.1 225854698 7678540 1105043..1105606 1 NC_012466.1 integral membrane protein 1105606 7678540 SPJ_1146 Streptococcus pneumoniae JJA integral membrane protein YP_002736210.1 1105043 D 488222 CDS YP_002736211.1 225854699 7679177 1105884..1106411 1 NC_012466.1 hypothetical protein 1106411 7679177 SPJ_1147 Streptococcus pneumoniae JJA hypothetical protein YP_002736211.1 1105884 D 488222 CDS YP_002736212.1 225854700 7679882 1106423..1106938 1 NC_012466.1 identified by match to protein family HMM PF02829; match to protein family HMM PF08279; transcriptional regulator, biotin repressor family 1106938 7679882 SPJ_1149 Streptococcus pneumoniae JJA transcriptional regulator, biotin repressor family YP_002736212.1 1106423 D 488222 CDS YP_002736213.1 225854701 7679643 complement(1106935..1107402) 1 NC_012466.1 identified by match to protein family HMM PF00293; NTP pyrophosphohydrolase including oxidative damage repair enzymes 1107402 7679643 SPJ_1148 Streptococcus pneumoniae JJA NTP pyrophosphohydrolase including oxidative damage repair enzymes YP_002736213.1 1106935 R 488222 CDS YP_002736214.1 225854702 7679052 complement(1107476..1107964) 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 1107964 7679052 SPJ_1150 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002736214.1 1107476 R 488222 CDS YP_002736215.1 225854703 7679847 complement(1107930..1108493) 1 NC_012466.1 acetyltransferase, gnat family 1108493 7679847 SPJ_1151 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002736215.1 1107930 R 488222 CDS YP_002736216.1 225854704 7680353 complement(1108503..1110491) 1 NC_012466.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1110491 uvrB 7680353 uvrB Streptococcus pneumoniae JJA excinuclease ABC subunit B YP_002736216.1 1108503 R 488222 CDS YP_002736217.1 225854705 7679215 complement(1110568..1111521) 1 NC_012466.1 identified by match to protein family HMM PF02517; caax amino protease family 1111521 7679215 SPJ_1153 Streptococcus pneumoniae JJA caax amino protease family YP_002736217.1 1110568 R 488222 CDS YP_002736218.1 225854706 7679931 1111694..1113859 1 NC_012466.1 identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease/substrate-binding protein 1113859 7679931 SPJ_1154 Streptococcus pneumoniae JJA amino acid ABC transporter permease/substrate-binding protein YP_002736218.1 1111694 D 488222 CDS YP_002736219.1 225854707 7679876 1113859..1114599 1 NC_012466.1 identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 1114599 7679876 SPJ_1155 Streptococcus pneumoniae JJA glutamine transport ATP-binding protein GlnQ YP_002736219.1 1113859 D 488222 CDS YP_002736220.1 225854708 7680358 1114748..1116235 1 NC_012466.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1116235 zwf 7680358 zwf Streptococcus pneumoniae JJA glucose-6-phosphate 1-dehydrogenase YP_002736220.1 1114748 D 488222 CDS YP_002736221.1 225854709 7678585 complement(1116281..1117558) 1 NC_012466.1 identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM TIGR00064; cell division protein FtsY 1117558 7678585 SPJ_1157 Streptococcus pneumoniae JJA cell division protein FtsY YP_002736221.1 1116281 R 488222 CDS YP_002736222.1 225854710 7679129 complement(1117562..1118380) 1 NC_012466.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 1118380 7679129 SPJ_1158 Streptococcus pneumoniae JJA Cof family protein YP_002736222.1 1117562 R 488222 CDS YP_002736223.1 225854711 7679624 complement(1118380..1119174) 1 NC_012466.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 1119174 7679624 SPJ_1159 Streptococcus pneumoniae JJA Cof family protein YP_002736223.1 1118380 R 488222 CDS YP_002736224.1 225854712 7680111 complement(1119171..1122710) 1 NC_012466.1 identified by match to protein family HMM PF02463; match to protein family HMM PF06470; match to protein family HMM TIGR02168; chromosome segregation protein SMC 1122710 smc 7680111 smc Streptococcus pneumoniae JJA chromosome segregation protein SMC YP_002736224.1 1119171 R 488222 CDS YP_002736225.1 225854713 7678593 complement(1122701..1123399) 1 NC_012466.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 1123399 rnc 7678593 rnc Streptococcus pneumoniae JJA ribonuclease III YP_002736225.1 1122701 R 488222 CDS YP_002736226.1 225854714 7680582 complement(1123717..1124703) 1 NC_012466.1 identified by match to protein family HMM PF00478; match to protein family HMM TIGR01306; guanosine 5'-monophosphate oxidoreductase 1124703 guaC 7680582 guaC Streptococcus pneumoniae JJA guanosine 5'-monophosphate oxidoreductase YP_002736226.1 1123717 R 488222 CDS YP_002736227.1 225854715 7679618 complement(1124879..1126195) 1 NC_012466.1 hypothetical protein 1126195 7679618 SPJ_1164 Streptococcus pneumoniae JJA hypothetical protein YP_002736227.1 1124879 R 488222 CDS YP_002736228.1 225854716 7680057 complement(1126182..1128113) 1 NC_012466.1 hypothetical protein 1128113 7680057 SPJ_1165 Streptococcus pneumoniae JJA hypothetical protein YP_002736228.1 1126182 R 488222 CDS YP_002736229.1 225854717 7680488 complement(1128279..1128440) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1128440 7680488 SPJ_1166 Streptococcus pneumoniae JJA hypothetical protein YP_002736229.1 1128279 R 488222 CDS YP_002736230.1 225854718 7678905 complement(1128430..1128696) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1128696 7678905 SPJ_1167 Streptococcus pneumoniae JJA hypothetical protein YP_002736230.1 1128430 R 488222 CDS YP_002736231.1 225854719 7679265 complement(1128702..1128845) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1128845 7679265 SPJ_1168 Streptococcus pneumoniae JJA hypothetical protein YP_002736231.1 1128702 R 488222 CDS YP_002736232.1 225854720 7679868 complement(1129064..1129423) 1 NC_012466.1 hypothetical protein 1129423 7679868 SPJ_1169 Streptococcus pneumoniae JJA hypothetical protein YP_002736232.1 1129064 R 488222 CDS YP_002736233.1 225854721 7679057 complement(1129427..1129696) 1 NC_012466.1 identified by match to protein family HMM PF06961; hypothetical protein 1129696 7679057 SPJ_1170 Streptococcus pneumoniae JJA hypothetical protein YP_002736233.1 1129427 R 488222 CDS YP_002736234.1 225854722 7679517 complement(1129693..1130730) 1 NC_012466.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 1130730 leuB 7679517 leuB Streptococcus pneumoniae JJA 3-isopropylmalate dehydrogenase YP_002736234.1 1129693 R 488222 CDS YP_002736235.1 225854723 7678611 complement(1131855..1132511) 1 NC_012466.1 identified by match to protein family HMM PF04237; hypothetical protein 1132511 7678611 SPJ_1174 Streptococcus pneumoniae JJA hypothetical protein YP_002736235.1 1131855 R 488222 CDS YP_002736236.1 225854724 7679212 complement(1132555..1133187) 1 NC_012466.1 identified by match to protein family HMM PF03932; copper sensitivity 1133187 7679212 SPJ_1175 Streptococcus pneumoniae JJA copper sensitivity YP_002736236.1 1132555 R 488222 CDS YP_002736237.1 225854725 7680533 complement(1133280..1133639) 1 NC_012466.1 identified by match to protein family HMM PF04304; hypothetical protein 1133639 7680533 SPJ_1176 Streptococcus pneumoniae JJA hypothetical protein YP_002736237.1 1133280 R 488222 CDS YP_002736238.1 225854726 7679919 complement(1133745..1135832) 1 NC_012466.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1135832 topA 7679919 topA Streptococcus pneumoniae JJA DNA topoisomerase I YP_002736238.1 1133745 R 488222 CDS YP_002736239.1 225854727 7679889 complement(1135999..1137042) 1 NC_012466.1 identified by match to protein family HMM PF04087; hypothetical protein 1137042 7679889 SPJ_1178 Streptococcus pneumoniae JJA hypothetical protein YP_002736239.1 1135999 R 488222 CDS YP_002736240.1 225854728 7679251 1137625..1137747 1 NC_012466.1 chlorohydrolase 1137747 7679251 SPJ_1179 Streptococcus pneumoniae JJA chlorohydrolase YP_002736240.1 1137625 D 488222 CDS YP_002736241.1 225854729 7678787 complement(1137931..1138779) 1 NC_012466.1 identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732; DNA protecting protein DprA 1138779 dprA 7678787 dprA Streptococcus pneumoniae JJA DNA protecting protein DprA YP_002736241.1 1137931 R 488222 CDS YP_002736242.1 225854730 7679686 complement(1138875..1139564) 1 NC_012466.1 identified by match to protein family HMM PF00483; LicC protein 1139564 7679686 SPJ_1181 Streptococcus pneumoniae JJA LicC protein YP_002736242.1 1138875 R 488222 CDS YP_002736243.1 225854731 7678519 complement(1139576..1140454) 1 NC_012466.1 identified by match to protein family HMM PF00892; LPS epitope expression regulatory protein 1140454 7678519 SPJ_1182 Streptococcus pneumoniae JJA LPS epitope expression regulatory protein YP_002736243.1 1139576 R 488222 CDS YP_002736244.1 225854732 7680084 complement(1140444..1141313) 1 NC_012466.1 identified by match to protein family HMM PF01633; match to protein family HMM PF01636; choline kinase 1141313 7680084 SPJ_1183 Streptococcus pneumoniae JJA choline kinase YP_002736244.1 1140444 R 488222 CDS YP_002736245.1 225854733 7679941 complement(1141330..1142352) 1 NC_012466.1 identified by match to protein family HMM PF08240; xylitol dehydrogenase 1142352 7679941 SPJ_1184 Streptococcus pneumoniae JJA xylitol dehydrogenase YP_002736245.1 1141330 R 488222 CDS YP_002736246.1 225854734 7679302 complement(1142357..1143064) 1 NC_012466.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1143064 ispD 7679302 ispD Streptococcus pneumoniae JJA 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_002736246.1 1142357 R 488222 CDS YP_002736247.1 225854735 7679987 1143400..1144887 1 NC_012466.1 identified by match to protein family HMM PF01943; match to protein family HMM PF03023; virulence factor mvin superfamily 1144887 7679987 SPJ_1186 Streptococcus pneumoniae JJA virulence factor mvin superfamily YP_002736247.1 1143400 D 488222 CDS YP_002736248.1 225854736 7679841 1144897..1145700 1 NC_012466.1 required for phosphorylcholine incorporation in teichoic and lipoteichoic acids; identified by match to protein family HMM PF04991; phosphotransferase 1145700 7679841 SPJ_1187 Streptococcus pneumoniae JJA phosphotransferase YP_002736248.1 1144897 D 488222 CDS YP_002736249.1 225854737 7679228 1145702..1146511 1 NC_012466.1 identified by match to protein family HMM PF04991; LicD Protein 1146511 7679228 SPJ_1188 Streptococcus pneumoniae JJA LicD Protein YP_002736249.1 1145702 D 488222 CDS YP_002736250.1 225854738 7680244 complement(1146786..1149962) 1 NC_012466.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1149962 carB 7680244 carB Streptococcus pneumoniae JJA carbamoyl phosphate synthase large subunit YP_002736250.1 1146786 R 488222 CDS YP_002736251.1 225854739 7680431 complement(1150274..1151353) 1 NC_012466.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1151353 carA 7680431 carA Streptococcus pneumoniae JJA carbamoyl phosphate synthase small subunit YP_002736251.1 1150274 R 488222 CDS YP_002736252.1 225854740 7680114 complement(1151403..1152326) 1 NC_012466.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 1152326 pyrB 7680114 pyrB Streptococcus pneumoniae JJA aspartate carbamoyltransferase catalytic subunit YP_002736252.1 1151403 R 488222 CDS YP_002736253.1 225854741 7678646 complement(1152345..1152866) 1 NC_012466.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase 1152866 7678646 SPJ_1192 Streptococcus pneumoniae JJA bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase YP_002736253.1 1152345 R 488222 CDS YP_002736254.1 225854742 7679160 complement(1153077..1153706) 1 NC_012466.1 identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01083; endonuclease III 1153706 nth 7679160 nth Streptococcus pneumoniae JJA endonuclease III YP_002736254.1 1153077 R 488222 CDS YP_002736255.1 225854743 7679901 complement(1153706..1154248) 1 NC_012466.1 identified by match to protein family HMM PF02620; hypothetical protein 1154248 7679901 SPJ_1194 Streptococcus pneumoniae JJA hypothetical protein YP_002736255.1 1153706 R 488222 CDS YP_002736256.1 225854744 7680350 1154417..1154557 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1154557 7680350 SPJ_1195 Streptococcus pneumoniae JJA hypothetical protein YP_002736256.1 1154417 D 488222 CDS YP_002736257.1 225854745 7679334 1154982..1155935 1 NC_012466.1 identified by match to protein family HMM PF00665; transposase 1155935 7679334 SPJ_1196 Streptococcus pneumoniae JJA transposase YP_002736257.1 1154982 D 488222 CDS YP_002736258.1 225854746 7679821 1156217..1157776 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1157776 7679821 SPJ_1197 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002736258.1 1156217 D 488222 CDS YP_002736259.1 225854747 7680160 complement(1157925..1158824) 1 NC_012466.1 putative metalloprotease; heat shock protein HtpX 1158824 7680160 SPJ_1198 Streptococcus pneumoniae JJA heat shock protein HtpX YP_002736259.1 1157925 R 488222 CDS YP_002736260.1 225854748 7678856 complement(1158826..1159386) 1 NC_012466.1 identified by match to protein family HMM PF04011; cytoplasmic membrane protein 1159386 7678856 SPJ_1199 Streptococcus pneumoniae JJA cytoplasmic membrane protein YP_002736260.1 1158826 R 488222 CDS YP_002736261.1 225854749 7679201 1159480..1160193 1 NC_012466.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1160193 gidB 7679201 gidB Streptococcus pneumoniae JJA 16S rRNA methyltransferase GidB YP_002736261.1 1159480 D 488222 CDS YP_002736262.1 225854750 7679543 1160545..1161828 1 NC_012466.1 identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; uracil permease (Uracil transporter) 1161828 7679543 SPJ_1201 Streptococcus pneumoniae JJA uracil permease (Uracil transporter) YP_002736262.1 1160545 D 488222 CDS YP_002736263.1 225854751 7679066 complement(1162023..1163594) 1 NC_012466.1 identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959; signal recognition particle protein 1163594 ffh 7679066 ffh Streptococcus pneumoniae JJA signal recognition particle protein YP_002736263.1 1162023 R 488222 CDS YP_002736264.1 225854752 7679581 complement(1163606..1163938) 1 NC_012466.1 identified by match to protein family HMM PF04297; match to protein family HMM PF04967; match to protein family HMM PF08281; putative DNA-binding protein 1163938 7679581 SPJ_1203 Streptococcus pneumoniae JJA putative DNA-binding protein YP_002736264.1 1163606 R 488222 CDS YP_002736265.1 225854753 7679782 complement(1164029..1164406) 1 NC_012466.1 identified by match to protein family HMM PF09148; hypothetical protein 1164406 7679782 SPJ_1204 Streptococcus pneumoniae JJA hypothetical protein YP_002736265.1 1164029 R 488222 CDS YP_002736266.1 225854754 7678608 1164382..1165782 1 NC_012466.1 identified by match to protein family HMM PF01966; dGTP triphosphohydrolase 1165782 7678608 SPJ_1205 Streptococcus pneumoniae JJA dGTP triphosphohydrolase YP_002736266.1 1164382 D 488222 CDS YP_002736267.1 225854755 7678649 1165795..1166601 1 NC_012466.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; phosphatase YidA 1166601 7678649 SPJ_1206 Streptococcus pneumoniae JJA phosphatase YidA YP_002736267.1 1165795 D 488222 CDS YP_002736268.1 225854756 7679152 1166644..1167642 1 NC_012466.1 identified by match to protein family HMM PF02037; SAP domain protein 1167642 7679152 SPJ_1207 Streptococcus pneumoniae JJA SAP domain protein YP_002736268.1 1166644 D 488222 CDS YP_002736269.1 225854757 7680578 complement(1167921..1168268) 1 NC_012466.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1168268 rplS 7680578 rplS Streptococcus pneumoniae JJA 50S ribosomal protein L19 YP_002736269.1 1167921 R 488222 CDS YP_002736270.1 225854758 7680234 complement(1168387..1168716) 1 NC_012466.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1168716 7680234 SPJ_1210 Streptococcus pneumoniae JJA camphor resistance protein CrcB YP_002736270.1 1168387 R 488222 CDS YP_002736271.1 225854759 7679043 complement(1168710..1169084) 1 NC_012466.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1169084 7679043 SPJ_1211 Streptococcus pneumoniae JJA camphor resistance protein CrcB YP_002736271.1 1168710 R 488222 CDS YP_002736272.1 225854760 7679683 complement(1169081..1169347) 1 NC_012466.1 identified by match to protein family HMM PF01817; match to protein family HMM TIGR01805; hypothetical protein 1169347 7679683 SPJ_1212 Streptococcus pneumoniae JJA hypothetical protein YP_002736272.1 1169081 R 488222 CDS YP_002736273.1 225854761 7680543 complement(1169463..1169906) 1 NC_012466.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 1169906 7680543 SPJ_1213 Streptococcus pneumoniae JJA flavodoxin YP_002736273.1 1169463 R 488222 CDS YP_002736274.1 225854762 7678422 1170010..1170945 1 NC_012466.1 identified by match to protein family HMM PF01368; match to protein family HMM PF02272; DHH subfamily 1 protein 1170945 7678422 SPJ_1214 Streptococcus pneumoniae JJA DHH subfamily 1 protein YP_002736274.1 1170010 D 488222 CDS YP_002736275.1 225854763 7678791 1171041..1171283 1 NC_012466.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 1171283 rpmE2 7678791 rpmE2 Streptococcus pneumoniae JJA 50S ribosomal protein L31 type B YP_002736275.1 1171041 D 488222 CDS YP_002736276.1 225854764 7679419 complement(1171340..1171558) 1 NC_012466.1 high-affinity Fe2+/Pb2+ permease 1171558 7679419 SPJ_1216 Streptococcus pneumoniae JJA high-affinity Fe2+/Pb2+ permease YP_002736276.1 1171340 R 488222 CDS YP_002736277.1 225854765 7679120 complement(1171555..1171716) 1 NC_012466.1 hypothetical protein 1171716 7679120 SPJ_1217 Streptococcus pneumoniae JJA hypothetical protein YP_002736277.1 1171555 R 488222 CDS YP_002736278.1 225854766 7679697 complement(1171866..1172117) 1 NC_012466.1 transposase 1172117 7679697 SPJ_1218 Streptococcus pneumoniae JJA transposase YP_002736278.1 1171866 R 488222 CDS YP_002736279.1 225854767 7678602 1172643..1173989 1 NC_012466.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1173989 7678602 SPJ_1219 Streptococcus pneumoniae JJA glutamate dehydrogenase YP_002736279.1 1172643 D 488222 CDS YP_002736280.1 225854768 7678776 complement(1174495..1174665) 1 NC_012466.1 hypothetical protein 1174665 7678776 SPJ_1220 Streptococcus pneumoniae JJA hypothetical protein YP_002736280.1 1174495 R 488222 CDS YP_002736281.1 225854769 7679276 complement(1174678..1175124) 1 NC_012466.1 identified by match to protein family HMM PF00005; multidrug resistance protein 1 (ATP-binding cassettesub-family B member 1) (P-glycoprotein 1) (antigen) 1175124 7679276 SPJ_1221 Streptococcus pneumoniae JJA multidrug resistance protein 1 (ATP-binding cassettesub-family B member 1) (P-glycoprotein 1) (antigen) YP_002736281.1 1174678 R 488222 CDS YP_002736282.1 225854770 7680038 complement(1175314..1175661) 1 NC_012466.1 mobile genetic element 1175661 7680038 SPJ_1222 Streptococcus pneumoniae JJA mobile genetic element YP_002736282.1 1175314 R 488222 CDS YP_002736283.1 225854771 7678724 complement(1175678..1175800) 1 NC_012466.1 transposase protein A 1175800 7678724 SPJ_1223 Streptococcus pneumoniae JJA transposase protein A YP_002736283.1 1175678 R 488222 CDS YP_002736284.1 225854772 7679316 complement(1175895..1176077) 1 NC_012466.1 mobile genetic element 1176077 7679316 SPJ_1224 Streptococcus pneumoniae JJA mobile genetic element YP_002736284.1 1175895 R 488222 CDS YP_002736285.1 225854773 7679666 complement(1176170..1176328) 1 NC_012466.1 transposase 1176328 7679666 SPJ_1225 Streptococcus pneumoniae JJA transposase YP_002736285.1 1176170 R 488222 CDS YP_002736286.1 225854774 7680225 complement(1176591..1176761) 1 NC_012466.1 transposase 1176761 7680225 SPJ_1226 Streptococcus pneumoniae JJA transposase YP_002736286.1 1176591 R 488222 CDS YP_002736287.1 225854775 7679147 complement(1176923..1177363) 1 NC_012466.1 transposase 1177363 7679147 SPJ_1227 Streptococcus pneumoniae JJA transposase YP_002736287.1 1176923 R 488222 CDS YP_002736288.1 225854776 7680309 1177396..1177548 1 NC_012466.1 transposase family protein 1177548 7680309 SPJ_1228 Streptococcus pneumoniae JJA transposase family protein YP_002736288.1 1177396 D 488222 CDS YP_002736289.1 225854777 7679596 complement(1177817..1178140) 1 NC_012466.1 identified by match to protein family HMM PF05717; transposase 1178140 7679596 SPJ_1229 Streptococcus pneumoniae JJA transposase YP_002736289.1 1177817 R 488222 CDS YP_002736290.1 225854778 7679086 complement(1178121..1178306) 1 NC_012466.1 hypothetical protein 1178306 7679086 SPJ_1230 Streptococcus pneumoniae JJA hypothetical protein YP_002736290.1 1178121 R 488222 CDS YP_002736291.1 225854779 7678893 complement(1178579..1179190) 1 NC_012466.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit D 1179190 7678893 SPJ_1231 Streptococcus pneumoniae JJA V-type ATP synthase subunit D YP_002736291.1 1178579 R 488222 CDS YP_002736292.1 225854780 7680087 complement(1179213..1180598) 1 NC_012466.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit B 1180598 7680087 SPJ_1232 Streptococcus pneumoniae JJA V-type ATP synthase subunit B YP_002736292.1 1179213 R 488222 CDS YP_002736293.1 225854781 7679411 complement(1180599..1182374) 1 NC_012466.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit A 1182374 7679411 SPJ_1233 Streptococcus pneumoniae JJA V-type ATP synthase subunit A YP_002736293.1 1180599 R 488222 CDS YP_002736294.1 225854782 7678906 complement(1182437..1182757) 1 NC_012466.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the F subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit F 1182757 7678906 SPJ_1234 Streptococcus pneumoniae JJA V-type ATP synthase subunit F YP_002736294.1 1182437 R 488222 CDS YP_002736295.1 225854783 7678599 complement(1182747..1183754) 1 NC_012466.1 identified by match to protein family HMM PF01992; ATP synthase (C/AC39) subunit 1183754 7678599 SPJ_1235 Streptococcus pneumoniae JJA ATP synthase (C/AC39) subunit YP_002736295.1 1182747 R 488222 CDS YP_002736296.1 225854784 7679895 complement(1183819..1184400) 1 NC_012466.1 V-type sodium ATP synthase, subunit E 1184400 7679895 SPJ_1236 Streptococcus pneumoniae JJA V-type sodium ATP synthase, subunit E YP_002736296.1 1183819 R 488222 CDS YP_002736297.1 225854785 7679713 complement(1184434..1184910) 1 NC_012466.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits; V-type ATP synthase subunit K 1184910 7679713 SPJ_1237 Streptococcus pneumoniae JJA V-type ATP synthase subunit K YP_002736297.1 1184434 R 488222 CDS YP_002736298.1 225854786 7679211 complement(1184926..1186917) 1 NC_012466.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I is part of the membrane proton channel.; V-type ATP synthase subunit I 1186917 7679211 SPJ_1238 Streptococcus pneumoniae JJA V-type ATP synthase subunit I YP_002736298.1 1184926 R 488222 CDS YP_002736299.1 225854787 7680199 complement(1186907..1187230) 1 NC_012466.1 hypothetical protein 1187230 7680199 SPJ_1239 Streptococcus pneumoniae JJA hypothetical protein YP_002736299.1 1186907 R 488222 CDS YP_002736300.1 225854788 7679734 complement(1187255..1188145) 1 NC_012466.1 identified by match to protein family HMM PF00480; ROK family protein 1188145 7679734 SPJ_1240 Streptococcus pneumoniae JJA ROK family protein YP_002736300.1 1187255 R 488222 CDS YP_002736301.1 225854789 7680002 complement(1188302..1189411) 1 NC_012466.1 identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; match to protein family HMM PF03447; putative oxidoreductase YjhC 1189411 7680002 SPJ_1241 Streptococcus pneumoniae JJA putative oxidoreductase YjhC YP_002736301.1 1188302 R 488222 CDS YP_002736302.1 225854790 7678473 complement(1189451..1191673) 1 NC_012466.1 identified by match to protein family HMM PF02012; match to protein family HMM PF02973; sialidase B (Neuraminidase B) 1191673 7678473 SPJ_1242 Streptococcus pneumoniae JJA sialidase B (Neuraminidase B) YP_002736302.1 1189451 R 488222 CDS YP_002736303.1 225854791 7680472 complement(1191675..1192133) 1 NC_012466.1 identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 1192133 7680472 SPJ_1243 Streptococcus pneumoniae JJA hypothetical protein YP_002736303.1 1191675 R 488222 CDS YP_002736304.1 225854792 7679813 complement(1192152..1193693) 1 NC_012466.1 identified by match to protein family HMM PF00474; match to protein family HMM TIGR00813; sodium:solute symporter family protein 1193693 7679813 SPJ_1244 Streptococcus pneumoniae JJA sodium:solute symporter family protein YP_002736304.1 1192152 R 488222 CDS YP_002736305.1 225854793 7679510 complement(1193721..1194638) 1 NC_012466.1 identified by match to protein family HMM PF00701; N-acetylneuraminate lyase 1194638 7679510 SPJ_1245 Streptococcus pneumoniae JJA N-acetylneuraminate lyase YP_002736305.1 1193721 R 488222 CDS YP_002736306.1 225854794 7678888 complement(1194663..1195364) 1 NC_012466.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 1195364 7678888 SPJ_1246 Streptococcus pneumoniae JJA N-acetylmannosamine-6-phosphate 2-epimerase YP_002736306.1 1194663 R 488222 CDS YP_002736307.1 225854795 7678775 complement(1195369..1196178) 1 NC_012466.1 identified by match to protein family HMM PF01380; match to protein family HMM PF01418; transcriptional regulator, RpiR family 1196178 7678775 SPJ_1247 Streptococcus pneumoniae JJA transcriptional regulator, RpiR family YP_002736307.1 1195369 R 488222 CDS YP_002736308.1 225854796 7679267 complement(1196577..1197164) 1 NC_012466.1 identified by match to protein family HMM PF02517; caax amino protease family 1197164 7679267 SPJ_1248 Streptococcus pneumoniae JJA caax amino protease family YP_002736308.1 1196577 R 488222 CDS YP_002736309.1 225854797 7678786 complement(1197257..1197376) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1197376 7678786 SPJ_1249 Streptococcus pneumoniae JJA hypothetical protein YP_002736309.1 1197257 R 488222 CDS YP_002736310.1 225854798 7680467 complement(1197413..1197793) 1 NC_012466.1 hypothetical protein 1197793 7680467 SPJ_1250 Streptococcus pneumoniae JJA hypothetical protein YP_002736310.1 1197413 R 488222 CDS YP_002736311.1 225854799 7679984 complement(1197786..1198037) 1 NC_012466.1 hypothetical protein 1198037 7679984 SPJ_1251 Streptococcus pneumoniae JJA hypothetical protein YP_002736311.1 1197786 R 488222 CDS YP_002736312.1 225854800 7679060 complement(1198117..1198371) 1 NC_012466.1 identified by match to protein family HMM PF06970; replication intiation protein 1198371 7679060 SPJ_1252 Streptococcus pneumoniae JJA replication intiation protein YP_002736312.1 1198117 R 488222 CDS YP_002736313.1 225854801 7678455 complement(1198371..1198541) 1 NC_012466.1 hypothetical protein 1198541 7678455 SPJ_1253 Streptococcus pneumoniae JJA hypothetical protein YP_002736313.1 1198371 R 488222 CDS YP_002736314.1 225854802 7680172 complement(1198728..1199096) 1 NC_012466.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1199096 rplL 7680172 rplL Streptococcus pneumoniae JJA 50S ribosomal protein L7/L12 YP_002736314.1 1198728 R 488222 CDS YP_002736315.1 225854803 7679662 complement(1199172..1199672) 1 NC_012466.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1199672 rplJ 7679662 rplJ Streptococcus pneumoniae JJA 50S ribosomal protein L10 YP_002736315.1 1199172 R 488222 CDS YP_002736316.1 225854804 7678444 complement(1199922..1201433) 1 NC_012466.1 identified by match to protein family HMM PF01979; match to protein family HMM PF07969; chlorohydrolase 1201433 7678444 SPJ_1256 Streptococcus pneumoniae JJA chlorohydrolase YP_002736316.1 1199922 R 488222 CDS YP_002736317.1 225854805 7678923 complement(1201528..1203276) 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease 1203276 7678923 SPJ_1257 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein/permease YP_002736317.1 1201528 R 488222 CDS YP_002736318.1 225854806 7680482 complement(1203278..1205002) 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease 1205002 7680482 SPJ_1258 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein/permease YP_002736318.1 1203278 R 488222 CDS YP_002736319.1 225854807 7679609 complement(1205060..1205998) 1 NC_012466.1 identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; peptide methionine sulfoxide reductase MsrA/msrB 1205998 7679609 SPJ_1259 Streptococcus pneumoniae JJA peptide methionine sulfoxide reductase MsrA/msrB YP_002736319.1 1205060 R 488222 CDS YP_002736320.1 225854808 7678990 complement(1206428..1207297) 1 NC_012466.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1207297 thrB 7678990 thrB Streptococcus pneumoniae JJA homoserine kinase YP_002736320.1 1206428 R 488222 CDS YP_002736321.1 225854809 7678628 complement(1207299..1208585) 1 NC_012466.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1208585 7678628 SPJ_1261 Streptococcus pneumoniae JJA homoserine dehydrogenase YP_002736321.1 1207299 R 488222 CDS YP_002736322.1 225854810 7679993 complement(1208736..1209473) 1 NC_012466.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein 1209473 7679993 SPJ_1262 Streptococcus pneumoniae JJA adaptor protein YP_002736322.1 1208736 R 488222 CDS YP_002736323.1 225854811 7679246 complement(1209673..1210707) 1 NC_012466.1 hypothetical protein 1210707 7679246 SPJ_1263 Streptococcus pneumoniae JJA hypothetical protein YP_002736323.1 1209673 R 488222 CDS YP_002736324.1 225854812 7679595 complement(1210736..1212169) 1 NC_012466.1 hypothetical protein 1212169 7679595 SPJ_1264 Streptococcus pneumoniae JJA hypothetical protein YP_002736324.1 1210736 R 488222 CDS YP_002736325.1 225854813 7679118 complement(1212185..1213171) 1 NC_012466.1 identified by match to protein family HMM PF00535; glycosyl transferase, family 2 1213171 7679118 SPJ_1265 Streptococcus pneumoniae JJA glycosyl transferase, family 2 YP_002736325.1 1212185 R 488222 CDS YP_002736326.1 225854814 7678666 complement(1213173..1214273) 1 NC_012466.1 identified by match to protein family HMM PF00534; glycosyl transferase, group 1 1214273 7678666 SPJ_1266 Streptococcus pneumoniae JJA glycosyl transferase, group 1 YP_002736326.1 1213173 R 488222 CDS YP_002736327.1 225854815 7679007 complement(1214266..1215111) 1 NC_012466.1 identified by match to protein family HMM PF04991; licD3 protein 1215111 7679007 SPJ_1267 Streptococcus pneumoniae JJA licD3 protein YP_002736327.1 1214266 R 488222 CDS YP_002736328.1 225854816 7678788 complement(1215390..1216664) 1 NC_012466.1 identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; transcriptional regulator, LytR family 1216664 7678788 SPJ_1268 Streptococcus pneumoniae JJA transcriptional regulator, LytR family YP_002736328.1 1215390 R 488222 CDS YP_002736329.1 225854817 7679244 complement(1216661..1217509) 1 NC_012466.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 1217509 7679244 SPJ_1269 Streptococcus pneumoniae JJA prephenate dehydratase YP_002736329.1 1216661 R 488222 CDS YP_002736330.1 225854818 7680031 complement(1217506..1217982) 1 NC_012466.1 identified by match to protein family HMM PF01202; shikimate kinase 1217982 aroK 7680031 aroK Streptococcus pneumoniae JJA shikimate kinase YP_002736330.1 1217506 R 488222 CDS YP_002736331.1 225854819 7680478 complement(1217975..1219258) 1 NC_012466.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1219258 aroA 7680478 aroA Streptococcus pneumoniae JJA 3-phosphoshikimate 1-carboxyvinyltransferase YP_002736331.1 1217975 R 488222 CDS YP_002736332.1 225854820 7678979 complement(1219350..1219688) 1 NC_012466.1 identified by match to protein family HMM PF06133; hypothetical protein 1219688 7678979 SPJ_1272 Streptococcus pneumoniae JJA hypothetical protein YP_002736332.1 1219350 R 488222 CDS YP_002736333.1 225854821 7679521 complement(1219699..1220802) 1 NC_012466.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 1220802 7679521 SPJ_1273 Streptococcus pneumoniae JJA prephenate dehydrogenase YP_002736333.1 1219699 R 488222 CDS YP_002736334.1 225854822 7680148 complement(1220812..1221978) 1 NC_012466.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1221978 aroC 7680148 aroC Streptococcus pneumoniae JJA chorismate synthase YP_002736334.1 1220812 R 488222 CDS YP_002736335.1 225854823 7678575 complement(1221988..1223055) 1 NC_012466.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1223055 aroB 7678575 aroB Streptococcus pneumoniae JJA 3-dehydroquinate synthase YP_002736335.1 1221988 R 488222 CDS YP_002736336.1 225854824 7678509 complement(1223074..1223928) 1 NC_012466.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1223928 aroE 7678509 aroE Streptococcus pneumoniae JJA shikimate 5-dehydrogenase YP_002736336.1 1223074 R 488222 CDS YP_002736337.1 225854825 7680269 complement(1223918..1224595) 1 NC_012466.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1224595 aroD 7680269 aroD Streptococcus pneumoniae JJA 3-dehydroquinate dehydratase YP_002736337.1 1223918 R 488222 CDS YP_002736338.1 225854826 7678910 complement(1224592..1225755) 1 NC_012466.1 methyltransferase 1225755 7678910 SPJ_1278 Streptococcus pneumoniae JJA methyltransferase YP_002736338.1 1224592 R 488222 CDS YP_002736339.1 225854827 7679386 complement(1226440..1228074) 1 NC_012466.1 hypothetical protein 1228074 7679386 SPJ_1279 Streptococcus pneumoniae JJA hypothetical protein YP_002736339.1 1226440 R 488222 CDS YP_002736340.1 225854828 7679171 complement(1228055..1228804) 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1228804 7679171 SPJ_1280 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002736340.1 1228055 R 488222 CDS YP_002736341.1 225854829 7679528 1228983..1230437 1 NC_012466.1 converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 1230437 7679528 SPJ_1281 Streptococcus pneumoniae JJA cytoplasmic alpha-amylase YP_002736341.1 1228983 D 488222 CDS YP_002736342.1 225854830 7678729 complement(1230527..1233145) 1 NC_012466.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1233145 alaS 7678729 alaS Streptococcus pneumoniae JJA alanyl-tRNA synthetase YP_002736342.1 1230527 R 488222 CDS YP_002736343.1 225854831 7678549 complement(1233167..1233652) 1 NC_012466.1 identified by match to protein family HMM PF04525; hypothetical protein 1233652 7678549 SPJ_1283 Streptococcus pneumoniae JJA hypothetical protein YP_002736343.1 1233167 R 488222 CDS YP_002736344.1 225854832 7679406 complement(1233927..1234166) 1 NC_012466.1 hypothetical protein 1234166 7679406 SPJ_1284 Streptococcus pneumoniae JJA hypothetical protein YP_002736344.1 1233927 R 488222 CDS YP_002736345.1 225854833 7678892 complement(1234427..1235497) 1 NC_012466.1 identified by match to protein family HMM PF01547; spermidine/putrescine ABC transporter, spermidine/putrescine-binding protein 1235497 7678892 SPJ_1285 Streptococcus pneumoniae JJA spermidine/putrescine ABC transporter, spermidine/putrescine-binding protein YP_002736345.1 1234427 R 488222 CDS YP_002736346.1 225854834 7678594 complement(1235494..1236267) 1 NC_012466.1 identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease 1236267 7678594 SPJ_1286 Streptococcus pneumoniae JJA spermidine/putrescine ABC transporter permease YP_002736346.1 1235494 R 488222 CDS YP_002736347.1 225854835 7679452 complement(1236264..1237070) 1 NC_012466.1 identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease 1237070 7679452 SPJ_1287 Streptococcus pneumoniae JJA spermidine/putrescine ABC transporter permease YP_002736347.1 1236264 R 488222 CDS YP_002736348.1 225854836 7680115 complement(1237051..1238208) 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08402; spermidine/putrescine import ATP-binding protein PotA 1238208 7680115 SPJ_1288 Streptococcus pneumoniae JJA spermidine/putrescine import ATP-binding protein PotA YP_002736348.1 1237051 R 488222 CDS YP_002736349.1 225854837 7678658 complement(1238368..1239273) 1 NC_012466.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 1239273 murB 7678658 murB Streptococcus pneumoniae JJA UDP-N-acetylenolpyruvoylglucosamine reductase YP_002736349.1 1238368 R 488222 CDS YP_002736350.1 225854838 7679809 complement(1239385..1240137) 1 NC_012466.1 hypothetical protein 1240137 7679809 SPJ_1290 Streptococcus pneumoniae JJA hypothetical protein YP_002736350.1 1239385 R 488222 CDS YP_002736351.1 225854839 7680338 complement(1240147..1240878) 1 NC_012466.1 identified by match to protein family HMM PF03306; match to protein family HMM TIGR01252; alpha-acetolactate decarboxylase 1240878 budA 7680338 budA Streptococcus pneumoniae JJA alpha-acetolactate decarboxylase YP_002736351.1 1240147 R 488222 CDS YP_002736352.1 225854840 7680444 1241020..1242291 1 NC_012466.1 identified by match to protein family HMM PF00392; GntR family transcriptional regulator 1242291 7680444 SPJ_1292 Streptococcus pneumoniae JJA GntR family transcriptional regulator YP_002736352.1 1241020 D 488222 CDS YP_002736353.1 225854841 7678709 complement(1242311..1242997) 1 NC_012466.1 identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein - glutamine-binding protein 1242997 7678709 SPJ_1293 Streptococcus pneumoniae JJA ABC transporter substrate-binding protein - glutamine-binding protein YP_002736353.1 1242311 R 488222 CDS YP_002736354.1 225854842 7678938 complement(1243294..1243947) 1 NC_012466.1 identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU 1243947 phoU1 7678938 phoU1 Streptococcus pneumoniae JJA phosphate transport system regulatory protein PhoU YP_002736354.1 1243294 R 488222 CDS YP_002736355.1 225854843 7679559 complement(1243959..1244717) 1 NC_012466.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1244717 pstB1 7679559 pstB1 Streptococcus pneumoniae JJA phosphate transporter ATP-binding protein YP_002736355.1 1243959 R 488222 CDS YP_002736356.1 225854844 7679243 complement(1244730..1245533) 1 NC_012466.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1245533 pstB2 7679243 pstB2 Streptococcus pneumoniae JJA phosphate transporter ATP-binding protein YP_002736356.1 1244730 R 488222 CDS YP_002736357.1 225854845 7680281 complement(1245544..1246428) 1 NC_012466.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease 1246428 pstA1 7680281 pstA1 Streptococcus pneumoniae JJA phosphate ABC transporter permease YP_002736357.1 1245544 R 488222 CDS YP_002736358.1 225854846 7678687 complement(1246418..1247335) 1 NC_012466.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease 1247335 pstC1 7678687 pstC1 Streptococcus pneumoniae JJA phosphate ABC transporter permease YP_002736358.1 1246418 R 488222 CDS YP_002736359.1 225854847 7679306 complement(1247335..1248213) 1 NC_012466.1 identified by match to protein family HMM PF01547; match to protein family HMM TIGR02136; phosphate-binding protein PstS 1 (PBP 1) 1248213 7679306 SPJ_1299 Streptococcus pneumoniae JJA phosphate-binding protein PstS 1 (PBP 1) YP_002736359.1 1247335 R 488222 CDS YP_002736360.1 225854848 7679341 1248443..1248556 1 NC_012466.1 hypothetical protein 1248556 7679341 SPJ_1300 Streptococcus pneumoniae JJA hypothetical protein YP_002736360.1 1248443 D 488222 CDS YP_002736361.1 225854849 7680232 complement(1248787..1250091) 1 NC_012466.1 identified by match to protein family HMM PF01189; NOL1/NOP2/sun family protein 1250091 7680232 SPJ_1301 Streptococcus pneumoniae JJA NOL1/NOP2/sun family protein YP_002736361.1 1248787 R 488222 CDS YP_002736362.1 225854850 7678389 complement(1250092..1250865) 1 NC_012466.1 identified by match to protein family HMM PF00459; inositol monophosphatase family protein 1250865 7678389 SPJ_1302 Streptococcus pneumoniae JJA inositol monophosphatase family protein YP_002736362.1 1250092 R 488222 CDS YP_002736363.1 225854851 7678998 complement(1250855..1251133) 1 NC_012466.1 identified by match to protein family HMM PF05256; hypothetical protein 1251133 7678998 SPJ_1303 Streptococcus pneumoniae JJA hypothetical protein YP_002736363.1 1250855 R 488222 CDS YP_002736364.1 225854852 7679874 complement(1251133..1251534) 1 NC_012466.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 1251534 spxA 7679874 spxA Streptococcus pneumoniae JJA transcriptional regulator Spx YP_002736364.1 1251133 R 488222 CDS YP_002736365.1 225854853 7680463 complement(1251744..1252361) 1 NC_012466.1 identified by match to protein family HMM PF07314; match to protein family HMM TIGR01906; integral membrane protein 1252361 7680463 SPJ_1305 Streptococcus pneumoniae JJA integral membrane protein YP_002736365.1 1251744 R 488222 CDS YP_002736366.1 225854854 7678840 complement(1252351..1253124) 1 NC_012466.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01457; match to protein family HMM TIGR01460; HAD-superfamily subfamily IIA hydrolase 1253124 7678840 SPJ_1306 Streptococcus pneumoniae JJA HAD-superfamily subfamily IIA hydrolase YP_002736366.1 1252351 R 488222 CDS YP_002736367.1 225854855 7679109 complement(1253135..1253872) 1 NC_012466.1 identified by match to protein family HMM PF01643; acyl-ACP thioesterase 1253872 7679109 SPJ_1307 Streptococcus pneumoniae JJA acyl-ACP thioesterase YP_002736367.1 1253135 R 488222 CDS YP_002736368.1 225854856 7678588 complement(1253877..1255007) 1 NC_012466.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 1255007 7678588 SPJ_1308 Streptococcus pneumoniae JJA coproporphyrinogen III oxidase YP_002736368.1 1253877 R 488222 CDS YP_002736369.1 225854857 7679178 complement(1255091..1255480) 1 NC_012466.1 hypothetical protein 1255480 7679178 SPJ_1309 Streptococcus pneumoniae JJA hypothetical protein YP_002736369.1 1255091 R 488222 CDS YP_002736370.1 225854858 7679766 complement(1255496..1255879) 1 NC_012466.1 identified by match to protein family HMM PF06103; hypothetical protein 1255879 7679766 SPJ_1310 Streptococcus pneumoniae JJA hypothetical protein YP_002736370.1 1255496 R 488222 CDS YP_002736371.1 225854859 7680397 complement(1255880..1256668) 1 NC_012466.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1256668 lgt 7680397 lgt Streptococcus pneumoniae JJA prolipoprotein diacylglyceryl transferase YP_002736371.1 1255880 R 488222 CDS YP_002736372.1 225854860 7678808 complement(1256661..1257596) 1 NC_012466.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 1257596 hprK 7678808 hprK Streptococcus pneumoniae JJA HPr kinase/phosphorylase YP_002736372.1 1256661 R 488222 CDS YP_002736373.1 225854861 7679448 complement(1257726..1257902) 1 NC_012466.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1257902 rpsU 7679448 rpsU Streptococcus pneumoniae JJA 30S ribosomal protein S21 YP_002736373.1 1257726 R 488222 CDS YP_002736374.1 225854862 7680146 complement(1258042..1258749) 1 NC_012466.1 identified by match to protein family HMM PF01182; glucosamine-6-phosphate deaminase (glucosamine-6-phosphate isomerase) (gnpda) (glcn6p deaminase) 1258749 7680146 SPJ_1314 Streptococcus pneumoniae JJA glucosamine-6-phosphate deaminase (glucosamine-6-phosphate isomerase) (gnpda) (glcn6p deaminase) YP_002736374.1 1258042 R 488222 CDS YP_002736375.1 225854863 7678472 1258900..1259928 1 NC_012466.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 1259928 queA 7678472 queA Streptococcus pneumoniae JJA S-adenosylmethionine:tRNA ribosyltransferase-isomerase YP_002736375.1 1258900 D 488222 CDS YP_002736376.1 225854864 7680081 complement(1260589..1260978) 1 NC_012466.1 identified by match to protein family HMM PF01473; choline binding protein 1260978 7680081 SPJ_1316 Streptococcus pneumoniae JJA choline binding protein YP_002736376.1 1260589 R 488222 CDS YP_002736377.1 225854865 7680190 complement(1262439..1262990) 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 1262990 7680190 SPJ_1317 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002736377.1 1262439 R 488222 CDS YP_002736378.1 225854866 7679738 complement(1263340..1264164) 1 NC_012466.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1264164 nadE 7679738 nadE Streptococcus pneumoniae JJA NAD synthetase YP_002736378.1 1263340 R 488222 CDS YP_002736379.1 225854867 7679492 complement(1264161..1265621) 1 NC_012466.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1265621 pncB 7679492 pncB Streptococcus pneumoniae JJA nicotinate phosphoribosyltransferase YP_002736379.1 1264161 R 488222 CDS YP_002736380.1 225854868 7679176 complement(1265737..1266225) 1 NC_012466.1 hypothetical protein 1266225 7679176 SPJ_1320 Streptococcus pneumoniae JJA hypothetical protein YP_002736380.1 1265737 R 488222 CDS YP_002736381.1 225854869 7678536 complement(1266215..1266424) 1 NC_012466.1 identified by match to protein family HMM PF01381; hypothetical protein 1266424 7678536 SPJ_1321 Streptococcus pneumoniae JJA hypothetical protein YP_002736381.1 1266215 R 488222 CDS YP_002736382.1 225854870 7679828 complement(1266810..1267289) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1267289 7679828 SPJ_1322 Streptococcus pneumoniae JJA hypothetical protein YP_002736382.1 1266810 R 488222 CDS YP_002736383.1 225854871 7678489 complement(1268533..1269258) 1 NC_012466.1 identified by match to protein family HMM PF01136; peptidase, U32 family 1269258 7678489 SPJ_1325 Streptococcus pneumoniae JJA peptidase, U32 family YP_002736383.1 1268533 R 488222 CDS YP_002736384.1 225854872 7679239 complement(1269521..1269832) 1 NC_012466.1 identified by match to protein family HMM PF05495; CHY zinc finger domain protein 1269832 7679239 SPJ_1326 Streptococcus pneumoniae JJA CHY zinc finger domain protein YP_002736384.1 1269521 R 488222 CDS YP_002736385.1 225854873 7679305 complement(1269847..1271133) 1 NC_012466.1 identified by match to protein family HMM PF01136; peptidase, U32 family protein 1271133 7679305 SPJ_1327 Streptococcus pneumoniae JJA peptidase, U32 family protein YP_002736385.1 1269847 R 488222 CDS YP_002736386.1 225854874 7679185 1272311..1273528 1 NC_012466.1 identified by match to protein family HMM PF01555; DNA modification methyltransferase M.XbaI 1273528 7679185 SPJ_1330 Streptococcus pneumoniae JJA DNA modification methyltransferase M.XbaI YP_002736386.1 1272311 D 488222 CDS YP_002736387.1 225854875 7679646 1273775..1273921 1 NC_012466.1 hypothetical protein 1273921 7679646 SPJ_1331 Streptococcus pneumoniae JJA hypothetical protein YP_002736387.1 1273775 D 488222 CDS YP_002736388.1 225854876 7680272 complement(1274043..1275035) 1 NC_012466.1 identified by match to protein family HMM PF00165; AraC family transcriptional regulator 1275035 7680272 SPJ_1332 Streptococcus pneumoniae JJA AraC family transcriptional regulator YP_002736388.1 1274043 R 488222 CDS YP_002736389.1 225854877 7678408 1275195..1276949 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein/permease 1276949 7678408 SPJ_1333 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein/permease YP_002736389.1 1275195 D 488222 CDS YP_002736390.1 225854878 7679012 1276933..1278654 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1278654 7679012 SPJ_1334 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002736390.1 1276933 D 488222 CDS YP_002736391.1 225854879 7679739 1278665..1279249 1 NC_012466.1 identified by match to protein family HMM TIGR02185; hypothetical protein 1279249 7679739 SPJ_1335 Streptococcus pneumoniae JJA hypothetical protein YP_002736391.1 1278665 D 488222 CDS YP_002736392.1 225854880 7680377 1279249..1279944 1 NC_012466.1 identified by match to protein family HMM PF02361; cobalt transport protein 1279944 7680377 SPJ_1336 Streptococcus pneumoniae JJA cobalt transport protein YP_002736392.1 1279249 D 488222 CDS YP_002736393.1 225854881 7679733 1279932..1281296 1 NC_012466.1 identified by match to protein family HMM PF00005; cobalt ABC transporter, ATPase component, CbiO 1281296 7679733 SPJ_1337 Streptococcus pneumoniae JJA cobalt ABC transporter, ATPase component, CbiO YP_002736393.1 1279932 D 488222 CDS YP_002736394.1 225854882 7680254 complement(1282288..1282545) 1 NC_012466.1 transposase 1282545 7680254 SPJ_1338 Streptococcus pneumoniae JJA transposase YP_002736394.1 1282288 R 488222 CDS YP_002736395.1 225854883 7678438 complement(1282618..1282830) 1 NC_012466.1 transposase 1282830 7678438 SPJ_1339 Streptococcus pneumoniae JJA transposase YP_002736395.1 1282618 R 488222 CDS YP_002736396.1 225854884 7679001 complement(1282839..1283207) 1 NC_012466.1 transposase 1283207 7679001 SPJ_1340 Streptococcus pneumoniae JJA transposase YP_002736396.1 1282839 R 488222 CDS YP_002736397.1 225854885 7679946 complement(1283131..1283325) 1 NC_012466.1 hypothetical protein 1283325 7679946 SPJ_1341 Streptococcus pneumoniae JJA hypothetical protein YP_002736397.1 1283131 R 488222 CDS YP_002736398.1 225854886 7680495 complement(1283495..1283845) 1 NC_012466.1 identified by match to protein family HMM PF05717; transposase 1283845 7680495 SPJ_1342 Streptococcus pneumoniae JJA transposase YP_002736398.1 1283495 R 488222 CDS YP_002736399.1 225854887 7679415 complement(1283931..1284065) 1 NC_012466.1 hypothetical protein 1284065 7679415 SPJ_1343 Streptococcus pneumoniae JJA hypothetical protein YP_002736399.1 1283931 R 488222 CDS YP_002736400.1 225854888 7678898 complement(1284315..1285877) 1 NC_012466.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1285877 guaA 7678898 guaA Streptococcus pneumoniae JJA GMP synthase YP_002736400.1 1284315 R 488222 CDS YP_002736401.1 225854889 7680238 1286019..1286717 1 NC_012466.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 1286717 7680238 SPJ_1345 Streptococcus pneumoniae JJA GntR family transcriptional regulator YP_002736401.1 1286019 D 488222 CDS YP_002736402.1 225854890 7679940 complement(1286760..1287656) 1 NC_012466.1 identified by match to protein family HMM PF00892; membrane protein 1287656 7679940 SPJ_1346 Streptococcus pneumoniae JJA membrane protein YP_002736402.1 1286760 R 488222 CDS YP_002736403.1 225854891 7678761 complement(1287665..1288600) 1 NC_012466.1 identified by match to protein family HMM PF00144; beta-lactamase 1288600 7678761 SPJ_1347 Streptococcus pneumoniae JJA beta-lactamase YP_002736403.1 1287665 R 488222 CDS YP_002736404.1 225854892 7678941 complement(1288597..1289322) 1 NC_012466.1 CppA protein 1289322 7678941 SPJ_1348 Streptococcus pneumoniae JJA CppA protein YP_002736404.1 1288597 R 488222 CDS YP_002736405.1 225854893 7679758 complement(1289406..1290041) 1 NC_012466.1 identified by match to protein family HMM PF00657; hypothetical protein 1290041 7679758 SPJ_1349 Streptococcus pneumoniae JJA hypothetical protein YP_002736405.1 1289406 R 488222 CDS YP_002736406.1 225854894 7680487 complement(1290043..1290870) 1 NC_012466.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; hypothetical protein 1290870 7680487 SPJ_1350 Streptococcus pneumoniae JJA hypothetical protein YP_002736406.1 1290043 R 488222 CDS YP_002736407.1 225854895 7679250 1291984..1292133 1 NC_012466.1 hypothetical protein 1292133 7679250 SPJ_1354 Streptococcus pneumoniae JJA hypothetical protein YP_002736407.1 1291984 D 488222 CDS YP_002736408.1 225854896 7679436 complement(1292087..1292278) 1 NC_012466.1 hypothetical protein 1292278 7679436 SPJ_1353 Streptococcus pneumoniae JJA hypothetical protein YP_002736408.1 1292087 R 488222 CDS YP_002736409.1 225854897 7680154 1292457..1293068 1 NC_012466.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1293068 def 7680154 def Streptococcus pneumoniae JJA peptide deformylase YP_002736409.1 1292457 D 488222 CDS YP_002736410.1 225854898 7679196 1293113..1293841 1 NC_012466.1 identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; RNA methyltransferase, TrmH family, group 3 1293841 7679196 SPJ_1356 Streptococcus pneumoniae JJA RNA methyltransferase, TrmH family, group 3 YP_002736410.1 1293113 D 488222 CDS YP_002736411.1 225854899 7678530 complement(1293880..1294791) 1 NC_012466.1 identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01292; thioredoxin-disulfide reductase 1294791 trxB 7678530 trxB Streptococcus pneumoniae JJA thioredoxin-disulfide reductase YP_002736411.1 1293880 R 488222 CDS YP_002736412.1 225854900 7678876 complement(1294857..1295081) 1 NC_012466.1 hypothetical protein 1295081 7678876 SPJ_1358 Streptococcus pneumoniae JJA hypothetical protein YP_002736412.1 1294857 R 488222 CDS YP_002736413.1 225854901 7679219 complement(1295159..1295902) 1 NC_012466.1 identified by match to protein family HMM PF00005; L-cystine import ATP-binding protein TcyN 1295902 7679219 SPJ_1359 Streptococcus pneumoniae JJA L-cystine import ATP-binding protein TcyN YP_002736413.1 1295159 R 488222 CDS YP_002736414.1 225854902 7679505 complement(1295902..1296702) 1 NC_012466.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; aspartate/glutamate ABC transporter permease 1296702 7679505 SPJ_1360 Streptococcus pneumoniae JJA aspartate/glutamate ABC transporter permease YP_002736414.1 1295902 R 488222 CDS YP_002736415.1 225854903 7680476 complement(1296860..1297216) 1 NC_012466.1 identified by match to protein family HMM PF03960; match to protein family HMM TIGR01617; arsenate reductase 1297216 7680476 SPJ_1361 Streptococcus pneumoniae JJA arsenate reductase YP_002736415.1 1296860 R 488222 CDS YP_002736416.1 225854904 7678542 complement(1297229..1297741) 1 NC_012466.1 identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589; O6-methylguanine-DNA methyltransferase 1297741 7678542 SPJ_1362 Streptococcus pneumoniae JJA O6-methylguanine-DNA methyltransferase YP_002736416.1 1297229 R 488222 CDS YP_002736417.1 225854905 7678964 complement(1297741..1298235) 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 1298235 7678964 SPJ_1363 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002736417.1 1297741 R 488222 CDS YP_002736418.1 225854906 7679519 1298370..1298816 1 NC_012466.1 identified by match to protein family HMM PF08876; hypothetical protein 1298816 7679519 SPJ_1364 Streptococcus pneumoniae JJA hypothetical protein YP_002736418.1 1298370 D 488222 CDS YP_002736419.1 225854907 7680280 1298813..1299460 1 NC_012466.1 identified by match to protein family HMM PF03006; match to protein family HMM TIGR01065; hemolysin-3 (Hemolysin III) (Hly-III) 1299460 7680280 SPJ_1365 Streptococcus pneumoniae JJA hemolysin-3 (Hemolysin III) (Hly-III) YP_002736419.1 1298813 D 488222 CDS YP_002736420.1 225854908 7678579 complement(1299481..1300062) 1 NC_012466.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 1300062 7678579 SPJ_1366 Streptococcus pneumoniae JJA glutamine amidotransferase subunit PdxT YP_002736420.1 1299481 R 488222 CDS YP_002736421.1 225854909 7679322 complement(1300063..1300938) 1 NC_012466.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 1300938 7679322 SPJ_1367 Streptococcus pneumoniae JJA pyridoxal biosynthesis lyase PdxS YP_002736421.1 1300063 R 488222 CDS YP_002736422.1 225854910 7679657 complement(1301090..1302469) 1 NC_012466.1 identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; NADH oxidase (noxase) 1302469 7679657 SPJ_1368 Streptococcus pneumoniae JJA NADH oxidase (noxase) YP_002736422.1 1301090 R 488222 CDS YP_002736423.1 225854911 7680247 1302611..1302766 1 NC_012466.1 hypothetical protein 1302766 7680247 SPJ_1369 Streptococcus pneumoniae JJA hypothetical protein YP_002736423.1 1302611 D 488222 CDS YP_002736424.1 225854912 7678506 1302763..1303686 1 NC_012466.1 identified by match to protein family HMM PF02424; thiamine biosynthesis lipoprotein 1303686 7678506 SPJ_1370 Streptococcus pneumoniae JJA thiamine biosynthesis lipoprotein YP_002736424.1 1302763 D 488222 CDS YP_002736425.1 225854913 7678859 1303746..1304351 1 NC_012466.1 identified by match to protein family HMM PF03358; NADPH-dependent fmn reductase domain protein 1304351 7678859 SPJ_1371 Streptococcus pneumoniae JJA NADPH-dependent fmn reductase domain protein YP_002736425.1 1303746 D 488222 CDS YP_002736426.1 225854914 7679072 1304370..1305614 1 NC_012466.1 identified by match to protein family HMM PF03358; NADPH-dependent fmn reductase domain protein 1305614 7679072 SPJ_1372 Streptococcus pneumoniae JJA NADPH-dependent fmn reductase domain protein YP_002736426.1 1304370 D 488222 CDS YP_002736427.1 225854915 7679851 complement(1305837..1306094) 1 NC_012466.1 identified by match to protein family HMM PF05979; hypothetical protein 1306094 7679851 SPJ_1373 Streptococcus pneumoniae JJA hypothetical protein YP_002736427.1 1305837 R 488222 CDS YP_002736428.1 225854916 7679361 complement(1306136..1308172) 1 NC_012466.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 1308172 glyS 7679361 glyS Streptococcus pneumoniae JJA glycyl-tRNA synthetase subunit beta YP_002736428.1 1306136 R 488222 CDS YP_002736429.1 225854917 7679552 complement(1308432..1309349) 1 NC_012466.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 1309349 glyQ 7679552 glyQ Streptococcus pneumoniae JJA glycyl-tRNA synthetase subunit alpha YP_002736429.1 1308432 R 488222 CDS YP_002736430.1 225854918 7680109 complement(1309368..1310129) 1 NC_012466.1 hypothetical protein 1310129 7680109 SPJ_1376 Streptococcus pneumoniae JJA hypothetical protein YP_002736430.1 1309368 R 488222 CDS YP_002736431.1 225854919 7680183 complement(1310402..1311244) 1 NC_012466.1 identified by match to protein family HMM PF00248; 2,5-diketo-d-gluconic acid reductase a (2,5-dkgreductase a) (2,5-dkgr a) (25dkgr-a) (akr5c) 1311244 7680183 SPJ_1377 Streptococcus pneumoniae JJA 2,5-diketo-d-gluconic acid reductase a (2,5-dkgreductase a) (2,5-dkgr a) (25dkgr-a) (akr5c) YP_002736431.1 1310402 R 488222 CDS YP_002736432.1 225854920 7678722 complement(1311359..1312696) 1 NC_012466.1 identified by match to protein family HMM PF01522; peptidoglycan GlcNAc deacetylase 1312696 7678722 SPJ_1378 Streptococcus pneumoniae JJA peptidoglycan GlcNAc deacetylase YP_002736432.1 1311359 R 488222 CDS YP_002736433.1 225854921 7679474 complement(1312985..1313362) 1 NC_012466.1 hypothetical protein 1313362 7679474 SPJ_1379 Streptococcus pneumoniae JJA hypothetical protein YP_002736433.1 1312985 R 488222 CDS YP_002736434.1 225854922 7679963 1313541..1314554 1 NC_012466.1 identified by match to protein family HMM PF01118; match to protein family HMM PF01408; oxidoreductase 1314554 7679963 SPJ_1380 Streptococcus pneumoniae JJA oxidoreductase YP_002736434.1 1313541 D 488222 CDS YP_002736435.1 225854923 7679599 1314551..1315633 1 NC_012466.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; DEAD/DEAH box helicase 1315633 7679599 SPJ_1381 Streptococcus pneumoniae JJA DEAD/DEAH box helicase YP_002736435.1 1314551 D 488222 CDS YP_002736436.1 225854924 7680098 complement(1315697..1315858) 1 NC_012466.1 hypothetical protein 1315858 7680098 SPJ_1382 Streptococcus pneumoniae JJA hypothetical protein YP_002736436.1 1315697 R 488222 CDS YP_002736437.1 225854925 7678418 complement(1316238..1316423) 1 NC_012466.1 identified by match to protein family HMM PF01610; transposase 1316423 7678418 SPJ_1383 Streptococcus pneumoniae JJA transposase YP_002736437.1 1316238 R 488222 CDS YP_002736438.1 225854926 7680297 complement(1316377..1316727) 1 NC_012466.1 transposase 1316727 7680297 SPJ_1384 Streptococcus pneumoniae JJA transposase YP_002736438.1 1316377 R 488222 CDS YP_002736439.1 225854927 7678392 1317170..1317688 1 NC_012466.1 transposase 1317688 7678392 SPJ_1385 Streptococcus pneumoniae JJA transposase YP_002736439.1 1317170 D 488222 CDS YP_002736440.1 225854928 7679290 1317685..1317972 1 NC_012466.1 identified by match to protein family HMM PF01610; transposase 1317972 7679290 SPJ_1386 Streptococcus pneumoniae JJA transposase YP_002736440.1 1317685 D 488222 CDS YP_002736441.1 225854929 7679048 1317969..1318520 1 NC_012466.1 transposase 1318520 7679048 SPJ_1387 Streptococcus pneumoniae JJA transposase YP_002736441.1 1317969 D 488222 CDS YP_002736442.1 225854930 7679687 complement(1318604..1319800) 1 NC_012466.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1319800 tuf 7679687 tuf Streptococcus pneumoniae JJA elongation factor Tu YP_002736442.1 1318604 R 488222 CDS YP_002736443.1 225854931 7680286 complement(1319964..1320917) 1 NC_012466.1 identified by match to protein family HMM PF00665; transposase 1320917 7680286 SPJ_1389 Streptococcus pneumoniae JJA transposase YP_002736443.1 1319964 R 488222 CDS YP_002736444.1 225854932 7678917 complement(1321388..1321510) 1 NC_012466.1 hypothetical protein 1321510 7678917 SPJ_1390 Streptococcus pneumoniae JJA hypothetical protein YP_002736444.1 1321388 R 488222 CDS YP_002736445.1 225854933 7678427 complement(1321967..1322836) 1 NC_012466.1 identified by match to protein family HMM PF00230; glycerol facilitator-aquaporin gla (Aquaglyceroporin)(Glyceroaquaporin) 1322836 7678427 SPJ_1391 Streptococcus pneumoniae JJA glycerol facilitator-aquaporin gla (Aquaglyceroporin)(Glyceroaquaporin) YP_002736445.1 1321967 R 488222 CDS YP_002736446.1 225854934 7679894 complement(1323060..1323581) 1 NC_012466.1 identified by match to protein family HMM PF00746; match to protein family HMM PF06458; match to protein family HMM TIGR01167; MucBP domain family 1323581 7679894 SPJ_1392 Streptococcus pneumoniae JJA MucBP domain family YP_002736446.1 1323060 R 488222 CDS YP_002736447.1 225854935 7680366 complement(1323539..1324147) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1324147 7680366 SPJ_1393 Streptococcus pneumoniae JJA hypothetical protein YP_002736447.1 1323539 R 488222 CDS YP_002736448.1 225854936 7679404 complement(1324135..1324644) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1324644 7679404 SPJ_1394 Streptococcus pneumoniae JJA hypothetical protein YP_002736448.1 1324135 R 488222 CDS YP_002736449.1 225854937 7678727 complement(1324755..1325009) 1 NC_012466.1 hypothetical protein 1325009 7678727 SPJ_1395 Streptococcus pneumoniae JJA hypothetical protein YP_002736449.1 1324755 R 488222 CDS YP_002736450.1 225854938 7679532 complement(1325367..1325900) 1 NC_012466.1 transposase 1325900 7679532 SPJ_1396 Streptococcus pneumoniae JJA transposase YP_002736450.1 1325367 R 488222 CDS YP_002736451.1 225854939 7680163 complement(1325887..1326021) 1 NC_012466.1 hypothetical protein 1326021 7680163 SPJ_1397 Streptococcus pneumoniae JJA hypothetical protein YP_002736451.1 1325887 R 488222 CDS YP_002736452.1 225854940 7679122 complement(1326069..1326212) 1 NC_012466.1 hypothetical protein 1326212 7679122 SPJ_1398 Streptococcus pneumoniae JJA hypothetical protein YP_002736452.1 1326069 R 488222 CDS YP_002736453.1 225854941 7678642 1326446..1328164 1 NC_012466.1 identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880; phosphomannomutase 1328164 7678642 SPJ_1399 Streptococcus pneumoniae JJA phosphomannomutase YP_002736453.1 1326446 D 488222 CDS YP_002736454.1 225854942 7678822 1328275..1328622 1 NC_012466.1 identified by match to protein family HMM TIGR01295; bacterocin transport accessory protein 1328622 7678822 SPJ_1400 Streptococcus pneumoniae JJA bacterocin transport accessory protein YP_002736454.1 1328275 D 488222 CDS YP_002736455.1 225854943 7680492 complement(1328901..1329737) 1 NC_012466.1 identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein - glutamine transport 1329737 7680492 SPJ_1401 Streptococcus pneumoniae JJA ABC transporter substrate-binding protein - glutamine transport YP_002736455.1 1328901 R 488222 CDS YP_002736456.1 225854944 7680035 complement(1329750..1330379) 1 NC_012466.1 identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 1330379 7680035 SPJ_1402 Streptococcus pneumoniae JJA glutamine transport ATP-binding protein GlnQ YP_002736456.1 1329750 R 488222 CDS YP_002736457.1 225854945 7679004 complement(1330389..1331030) 1 NC_012466.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 1331030 7679004 SPJ_1403 Streptococcus pneumoniae JJA amino acid ABC transporter permease YP_002736457.1 1330389 R 488222 CDS YP_002736458.1 225854946 7680237 complement(1331176..1332405) 1 NC_012466.1 identified by match to protein family HMM PF00515; match to protein family HMM PF07719; TPR domain protein 1332405 7680237 SPJ_1404 Streptococcus pneumoniae JJA TPR domain protein YP_002736458.1 1331176 R 488222 CDS YP_002736459.1 225854947 7679264 complement(1332395..1333561) 1 NC_012466.1 identified by match to protein family HMM PF01594; transport protein 1333561 7679264 SPJ_1405 Streptococcus pneumoniae JJA transport protein YP_002736459.1 1332395 R 488222 CDS YP_002736460.1 225854948 7678759 1333705..1334718 1 NC_012466.1 3-carboxymuconate cyclase 1334718 7678759 SPJ_1406 Streptococcus pneumoniae JJA 3-carboxymuconate cyclase YP_002736460.1 1333705 D 488222 CDS YP_002736461.1 225854949 7680337 1334858..1335640 1 NC_012466.1 identified by match to protein family HMM PF01610; transposase 1335640 7680337 SPJ_1407 Streptococcus pneumoniae JJA transposase YP_002736461.1 1334858 D 488222 CDS YP_002736462.1 225854950 7678411 1335637..1336164 1 NC_012466.1 transposase 1336164 7678411 SPJ_1408 Streptococcus pneumoniae JJA transposase YP_002736462.1 1335637 D 488222 CDS YP_002736463.1 225854951 7679022 complement(1336235..1336654) 1 NC_012466.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 1336654 atpC 7679022 atpC Streptococcus pneumoniae JJA F0F1 ATP synthase subunit epsilon YP_002736463.1 1336235 R 488222 CDS YP_002736464.1 225854952 7680152 complement(1336665..1338071) 1 NC_012466.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 1338071 atpD 7680152 atpD Streptococcus pneumoniae JJA F0F1 ATP synthase subunit beta YP_002736464.1 1336665 R 488222 CDS YP_002736465.1 225854953 7678528 complement(1338157..1339035) 1 NC_012466.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 1339035 atpG 7678528 atpG Streptococcus pneumoniae JJA F0F1 ATP synthase subunit gamma YP_002736465.1 1338157 R 488222 CDS YP_002736466.1 225854954 7679205 complement(1339051..1340556) 1 NC_012466.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 1340556 atpA 7679205 atpA Streptococcus pneumoniae JJA F0F1 ATP synthase subunit alpha YP_002736466.1 1339051 R 488222 CDS YP_002736467.1 225854955 7679275 complement(1340571..1341107) 1 NC_012466.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 1341107 atpH 7679275 atpH Streptococcus pneumoniae JJA F0F1 ATP synthase subunit delta YP_002736467.1 1340571 R 488222 CDS YP_002736468.1 225854956 7679203 complement(1341107..1341601) 1 NC_012466.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 1341601 atpF 7679203 atpF Streptococcus pneumoniae JJA F0F1 ATP synthase subunit B YP_002736468.1 1341107 R 488222 CDS YP_002736469.1 225854957 7678563 complement(1341615..1342331) 1 NC_012466.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 1342331 atpB 7678563 atpB Streptococcus pneumoniae JJA F0F1 ATP synthase subunit A YP_002736469.1 1341615 R 488222 CDS YP_002736470.1 225854958 7679776 complement(1342366..1342566) 1 NC_012466.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 1342566 7679776 SPJ_1416 Streptococcus pneumoniae JJA F0F1 ATP synthase subunit C YP_002736470.1 1342366 R 488222 CDS YP_002736471.1 225854959 7678950 complement(1342641..1343648) 1 NC_012466.1 identified by match to protein family HMM PF00665; transposase 1343648 7678950 SPJ_1417 Streptococcus pneumoniae JJA transposase YP_002736471.1 1342641 R 488222 CDS YP_002736472.1 225854960 7679942 complement(1344093..1344491) 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family protein 1344491 7679942 SPJ_1418 Streptococcus pneumoniae JJA acetyltransferase, gnat family protein YP_002736472.1 1344093 R 488222 CDS YP_002736473.1 225854961 7680536 complement(1344999..1345481) 1 NC_012466.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1345481 greA 7680536 greA Streptococcus pneumoniae JJA transcription elongation factor GreA YP_002736473.1 1344999 R 488222 CDS YP_002736474.1 225854962 7680198 complement(1347288..1347782) 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 1347782 7680198 SPJ_1422 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002736474.1 1347288 R 488222 CDS YP_002736475.1 225854963 7678673 complement(1347779..1348243) 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 1348243 7678673 SPJ_1423 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002736475.1 1347779 R 488222 CDS YP_002736476.1 225854964 7679414 complement(1348253..1349587) 1 NC_012466.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1349587 murC 7679414 murC Streptococcus pneumoniae JJA UDP-N-acetylmuramate--L-alanine ligase YP_002736476.1 1348253 R 488222 CDS YP_002736477.1 225854965 7679588 complement(1349598..1350215) 1 NC_012466.1 hypothetical protein 1350215 7679588 SPJ_1425 Streptococcus pneumoniae JJA hypothetical protein YP_002736477.1 1349598 R 488222 CDS YP_002736478.1 225854966 7680056 complement(1353454..1354620) 1 NC_012466.1 identified by match to protein family HMM PF00155; putative aminotransferase B 1354620 7680056 SPJ_1428 Streptococcus pneumoniae JJA putative aminotransferase B YP_002736478.1 1353454 R 488222 CDS YP_002736479.1 225854967 7679961 complement(1354628..1355722) 1 NC_012466.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 1355722 7679961 SPJ_1429 Streptococcus pneumoniae JJA cystathionine gamma-synthase YP_002736479.1 1354628 R 488222 CDS YP_002736480.1 225854968 7678557 complement(1357733..1359691) 1 NC_012466.1 identified by match to protein family HMM PF00496; oligopeptide binding lipoprotein 1359691 7678557 SPJ_1432 Streptococcus pneumoniae JJA oligopeptide binding lipoprotein YP_002736480.1 1357733 R 488222 CDS YP_002736481.1 225854969 7679539 complement(1359895..1361517) 1 NC_012466.1 identified by match to protein family HMM PF01943; match to protein family HMM PF03023; polysaccharide transporter 1361517 7679539 SPJ_1433 Streptococcus pneumoniae JJA polysaccharide transporter YP_002736481.1 1359895 R 488222 CDS YP_002736482.1 225854970 7679006 1361623..1363068 1 NC_012466.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1363068 7679006 SPJ_1434 Streptococcus pneumoniae JJA UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase YP_002736482.1 1361623 D 488222 CDS YP_002736483.1 225854971 7679395 complement(1363111..1363308) 1 NC_012466.1 identified by match to protein family HMM PF05532; hypothetical protein 1363308 7679395 SPJ_1435 Streptococcus pneumoniae JJA hypothetical protein YP_002736483.1 1363111 R 488222 CDS YP_002736484.1 225854972 7678918 complement(1363409..1364005) 1 NC_012466.1 identified by match to protein family HMM PF08820; hypothetical protein 1364005 7678918 SPJ_1436 Streptococcus pneumoniae JJA hypothetical protein YP_002736484.1 1363409 R 488222 CDS YP_002736485.1 225854973 7680068 complement(1364042..1364554) 1 NC_012466.1 hypothetical protein 1364554 7680068 SPJ_1437 Streptococcus pneumoniae JJA hypothetical protein YP_002736485.1 1364042 R 488222 CDS YP_002736486.1 225854974 7679601 complement(1364640..1365575) 1 NC_012466.1 catalyzes the hydrolysis of pyrophosphate to phosphate; putative manganese-dependent inorganic pyrophosphatase 1365575 7679601 SPJ_1438 Streptococcus pneumoniae JJA putative manganese-dependent inorganic pyrophosphatase YP_002736486.1 1364640 R 488222 CDS YP_002736487.1 225854975 7679028 complement(1365646..1365945) 1 NC_012466.1 identified by match to protein family HMM PF01541; hypothetical protein 1365945 7679028 SPJ_1439 Streptococcus pneumoniae JJA hypothetical protein YP_002736487.1 1365646 R 488222 CDS YP_002736488.1 225854976 7678409 complement(1365935..1366684) 1 NC_012466.1 identified by match to protein family HMM PF05175; methyltransferase 1366684 7678409 SPJ_1440 Streptococcus pneumoniae JJA methyltransferase YP_002736488.1 1365935 R 488222 CDS YP_002736489.1 225854977 7679050 complement(1366738..1367124) 1 NC_012466.1 identified by match to protein family HMM PF00575; hypothetical protein 1367124 7679050 SPJ_1441 Streptococcus pneumoniae JJA hypothetical protein YP_002736489.1 1366738 R 488222 CDS YP_002736490.1 225854978 7678433 complement(1367099..1368499) 1 NC_012466.1 identified by match to protein family HMM PF00160; match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein/peptidyl-prolyl cis-trans isomerase, cyclophilin type 1368499 7678433 SPJ_1442 Streptococcus pneumoniae JJA Cof family protein/peptidyl-prolyl cis-trans isomerase, cyclophilin type YP_002736490.1 1367099 R 488222 CDS YP_002736491.1 225854979 7680502 complement(1368794..1369033) 1 NC_012466.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 1369033 rpsR 7680502 rpsR Streptococcus pneumoniae JJA 30S ribosomal protein S18 YP_002736491.1 1368794 R 488222 CDS YP_002736492.1 225854980 7679908 complement(1369065..1369535) 1 NC_012466.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1369535 7679908 SPJ_1444 Streptococcus pneumoniae JJA single-stranded DNA-binding protein YP_002736492.1 1369065 R 488222 CDS YP_002736493.1 225854981 7679333 complement(1369547..1369837) 1 NC_012466.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 1369837 rpsF 7679333 rpsF Streptococcus pneumoniae JJA 30S ribosomal protein S6 YP_002736493.1 1369547 R 488222 CDS YP_002736494.1 225854982 7678671 complement(1369990..1371333) 1 NC_012466.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1371333 asnC 7678671 asnC Streptococcus pneumoniae JJA asparaginyl-tRNA synthetase YP_002736494.1 1369990 R 488222 CDS YP_002736495.1 225854983 7678692 complement(1371352..1371717) 1 NC_012466.1 identified by match to protein family HMM PF00903; glyoxalase family protein 1371717 7678692 SPJ_1447 Streptococcus pneumoniae JJA glyoxalase family protein YP_002736495.1 1371352 R 488222 CDS YP_002736496.1 225854984 7679227 complement(1371710..1372897) 1 NC_012466.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 1372897 7679227 SPJ_1448 Streptococcus pneumoniae JJA aspartate aminotransferase YP_002736496.1 1371710 R 488222 CDS YP_002736497.1 225854985 7678785 complement(1372894..1373382) 1 NC_012466.1 identified by match to protein family HMM PF03413; peptidase propeptide and ypeb domain protein 1373382 7678785 SPJ_1449 Streptococcus pneumoniae JJA peptidase propeptide and ypeb domain protein YP_002736497.1 1372894 R 488222 CDS YP_002736498.1 225854986 7679277 complement(1373449..1373565) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1373565 7679277 SPJ_1450 Streptococcus pneumoniae JJA hypothetical protein YP_002736498.1 1373449 R 488222 CDS YP_002736499.1 225854987 7680024 1373703..1374251 1 NC_012466.1 identified by match to protein family HMM PF02525; match to protein family HMM PF03358; oxidoreductase 1374251 7680024 SPJ_1451 Streptococcus pneumoniae JJA oxidoreductase YP_002736499.1 1373703 D 488222 CDS YP_002736500.1 225854988 7680483 complement(1374489..1380806) 1 NC_012466.1 identified by match to protein family HMM PF01391; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; G5 domain family 1380806 7680483 SPJ_1452 Streptococcus pneumoniae JJA G5 domain family YP_002736500.1 1374489 R 488222 CDS YP_002736501.1 225854989 7678488 1381022..1382506 1 NC_012466.1 identified by match to protein family HMM PF05043; match to protein family HMM PF08270; match to protein family HMM PF08279; match to protein family HMM PF08280; M protein trans-acting positive transcriptional regulator 1382506 7678488 SPJ_1453 Streptococcus pneumoniae JJA M protein trans-acting positive transcriptional regulator YP_002736501.1 1381022 D 488222 CDS YP_002736502.1 225854990 7678983 complement(1382557..1383285) 1 NC_012466.1 identified by match to protein family HMM PF03883; hypothetical protein 1383285 7678983 SPJ_1454 Streptococcus pneumoniae JJA hypothetical protein YP_002736502.1 1382557 R 488222 CDS YP_002736503.1 225854991 7679731 complement(1383364..1383528) 1 NC_012466.1 hypothetical protein 1383528 7679731 SPJ_1455 Streptococcus pneumoniae JJA hypothetical protein YP_002736503.1 1383364 R 488222 CDS YP_002736504.1 225854992 7678770 complement(1383707..1385302) 1 NC_012466.1 hypothetical protein 1385302 7678770 SPJ_1456 Streptococcus pneumoniae JJA hypothetical protein YP_002736504.1 1383707 R 488222 CDS YP_002736505.1 225854993 7680144 complement(1385314..1385724) 1 NC_012466.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1385724 def2 7680144 def2 Streptococcus pneumoniae JJA peptide deformylase YP_002736505.1 1385314 R 488222 CDS YP_002736506.1 225854994 7679544 complement(1385840..1386631) 1 NC_012466.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli; putative glutathione S-transferase YghU 1386631 7679544 SPJ_1458 Streptococcus pneumoniae JJA putative glutathione S-transferase YghU YP_002736506.1 1385840 R 488222 CDS YP_002736507.1 225854995 7679083 complement(1386644..1389340) 1 NC_012466.1 identified by match to protein family HMM PF00122; match to protein family HMM PF00689; match to protein family HMM PF00690; match to protein family HMM PF00702; match to protein family HMM TIGR01494; calcium-transporting ATPase 1 1389340 7679083 SPJ_1459 Streptococcus pneumoniae JJA calcium-transporting ATPase 1 YP_002736507.1 1386644 R 488222 CDS YP_002736508.1 225854996 7678739 1389644..1390828 1 NC_012466.1 identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation efflux family protein 1390828 7678739 SPJ_1460 Streptococcus pneumoniae JJA cation efflux family protein YP_002736508.1 1389644 D 488222 CDS YP_002736509.1 225854997 7679951 complement(1390971..1392842) 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1392842 7679951 SPJ_1461 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002736509.1 1390971 R 488222 CDS YP_002736510.1 225854998 7679464 complement(1392839..1394023) 1 NC_012466.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 1394023 7679464 SPJ_1462 Streptococcus pneumoniae JJA tRNA CCA-pyrophosphorylase YP_002736510.1 1392839 R 488222 CDS YP_002736511.1 225854999 7680051 complement(1394035..1394802) 1 NC_012466.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 1394802 dapB 7680051 dapB Streptococcus pneumoniae JJA dihydrodipicolinate reductase YP_002736511.1 1394035 R 488222 CDS YP_002736512.1 225855000 7679557 complement(1395079..1395927) 1 NC_012466.1 identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; hypothetical protein 1395927 7679557 SPJ_1464 Streptococcus pneumoniae JJA hypothetical protein YP_002736512.1 1395079 R 488222 CDS YP_002736513.1 225855001 7679614 complement(1395929..1396303) 1 NC_012466.1 identified by match to protein family HMM PF06619; hypothetical protein 1396303 7679614 SPJ_1465 Streptococcus pneumoniae JJA hypothetical protein YP_002736513.1 1395929 R 488222 CDS YP_002736514.1 225855002 7679127 complement(1396377..1397729) 1 NC_012466.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1397729 glmM 7679127 glmM Streptococcus pneumoniae JJA phosphoglucosamine mutase YP_002736514.1 1396377 R 488222 CDS YP_002736515.1 225855003 7678647 complement(1397753..1398532) 1 NC_012466.1 identified by match to protein family HMM PF07949; lipoprotein, putative 1398532 7678647 SPJ_1467 Streptococcus pneumoniae JJA lipoprotein, putative YP_002736515.1 1397753 R 488222 CDS YP_002736516.1 225855004 7680346 complement(1398519..1399376) 1 NC_012466.1 identified by match to protein family HMM PF02457; match to protein family HMM TIGR00159; hypothetical protein 1399376 7680346 SPJ_1468 Streptococcus pneumoniae JJA hypothetical protein YP_002736516.1 1398519 R 488222 CDS YP_002736517.1 225855005 7679220 1399512..1400480 1 NC_012466.1 identified by match to protein family HMM PF00070; match to protein family HMM PF03486; match to protein family HMM PF07992; thioredoxin reductase 1400480 7679220 SPJ_1469 Streptococcus pneumoniae JJA thioredoxin reductase YP_002736517.1 1399512 D 488222 CDS YP_002736518.1 225855006 7678735 complement(1400514..1401425) 1 NC_012466.1 identified by match to protein family HMM PF02650; match to protein family HMM TIGR00647; hypothetical protein 1401425 7678735 SPJ_1470 Streptococcus pneumoniae JJA hypothetical protein YP_002736518.1 1400514 R 488222 CDS YP_002736519.1 225855007 7680437 complement(1401422..1402399) 1 NC_012466.1 identified by match to protein family HMM PF01933; match to protein family HMM TIGR01826; transporter 1402399 7680437 SPJ_1471 Streptococcus pneumoniae JJA transporter YP_002736519.1 1401422 R 488222 CDS YP_002736520.1 225855008 7680099 complement(1402396..1403286) 1 NC_012466.1 identified by match to protein family HMM PF03668; hypothetical protein 1403286 7680099 SPJ_1472 Streptococcus pneumoniae JJA hypothetical protein YP_002736520.1 1402396 R 488222 CDS YP_002736521.1 225855009 7678982 complement(1403338..1403718) 1 NC_012466.1 identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004; endoribonuclease L-PSP, putative 1403718 7678982 SPJ_1473 Streptococcus pneumoniae JJA endoribonuclease L-PSP, putative YP_002736521.1 1403338 R 488222 CDS YP_002736522.1 225855010 7678552 complement(1403729..1404316) 1 NC_012466.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 1404316 engB 7678552 engB Streptococcus pneumoniae JJA ribosome biogenesis GTP-binding protein YsxC YP_002736522.1 1403729 R 488222 CDS YP_002736523.1 225855011 7680301 complement(1404325..1405557) 1 NC_012466.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1405557 clpX 7680301 clpX Streptococcus pneumoniae JJA ATP-dependent protease ATP-binding subunit ClpX YP_002736523.1 1404325 R 488222 CDS YP_002736524.1 225855012 7679822 complement(1405589..1405759) 1 NC_012466.1 hypothetical protein 1405759 7679822 SPJ_1476 Streptococcus pneumoniae JJA hypothetical protein YP_002736524.1 1405589 R 488222 CDS YP_002736525.1 225855013 7678484 complement(1405759..1406265) 1 NC_012466.1 identified by match to protein family HMM PF00186; dihydrofolate reductase 1406265 folA 7678484 folA Streptococcus pneumoniae JJA dihydrofolate reductase YP_002736525.1 1405759 R 488222 CDS YP_002736526.1 225855014 7678951 complement(1406395..1406913) 1 NC_012466.1 identified by match to protein family HMM PF00210; DNA protection during starvation protein 1406913 7678951 SPJ_1478 Streptococcus pneumoniae JJA DNA protection during starvation protein YP_002736526.1 1406395 R 488222 CDS YP_002736527.1 225855015 7680020 complement(1407411..1408883) 1 NC_012466.1 identified by match to protein family HMM PF01183; match to protein family HMM PF01473; 1,4-beta-N-acetylmuramidase 1408883 7680020 SPJ_1479 Streptococcus pneumoniae JJA 1,4-beta-N-acetylmuramidase YP_002736527.1 1407411 R 488222 CDS YP_002736528.1 225855016 7680451 complement(1408954..1409712) 1 NC_012466.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1409712 tpiA 7680451 tpiA Streptococcus pneumoniae JJA triosephosphate isomerase YP_002736528.1 1408954 R 488222 CDS YP_002736529.1 225855017 7679664 complement(1409810..1410487) 1 NC_012466.1 identified by match to protein family HMM PF04271; match to protein family HMM TIGR01446; DNA replication protein DnaD 1410487 7679664 SPJ_1481 Streptococcus pneumoniae JJA DNA replication protein DnaD YP_002736529.1 1409810 R 488222 CDS YP_002736530.1 225855018 7678736 complement(1410496..1411440) 1 NC_012466.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 1411440 metA 7678736 metA Streptococcus pneumoniae JJA homoserine O-succinyltransferase YP_002736530.1 1410496 R 488222 CDS YP_002736531.1 225855019 7678478 1411480..1411635 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1411635 7678478 SPJ_1484 Streptococcus pneumoniae JJA hypothetical protein YP_002736531.1 1411480 D 488222 CDS YP_002736532.1 225855020 7680510 complement(1411622..1412152) 1 NC_012466.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1412152 apt 7680510 apt Streptococcus pneumoniae JJA adenine phosphoribosyltransferase YP_002736532.1 1411622 R 488222 CDS YP_002736533.1 225855021 7678937 complement(1412222..1412980) 1 NC_012466.1 identified by match to protein family HMM PF08241; match to protein family HMM PF08242; SAM-dependent methyltransferase 1412980 7678937 SPJ_1485 Streptococcus pneumoniae JJA SAM-dependent methyltransferase YP_002736533.1 1412222 R 488222 CDS YP_002736534.1 225855022 7678810 1413188..1413358 1 NC_012466.1 hypothetical protein 1413358 7678810 SPJ_1486 Streptococcus pneumoniae JJA hypothetical protein YP_002736534.1 1413188 D 488222 CDS YP_002736535.1 225855023 7678965 complement(1413481..1414611) 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; multiple sugar-binding transport ATP-binding protein MsmK 1414611 7678965 SPJ_1487 Streptococcus pneumoniae JJA multiple sugar-binding transport ATP-binding protein MsmK YP_002736535.1 1413481 R 488222 CDS YP_002736536.1 225855024 7680568 complement(1415061..1415636) 1 NC_012466.1 identified by match to protein family HMM PF00857; isochorismatase 1415636 7680568 SPJ_1489 Streptococcus pneumoniae JJA isochorismatase YP_002736536.1 1415061 R 488222 CDS YP_002736537.1 225855025 7679394 complement(1415636..1416424) 1 NC_012466.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY 1416424 codY 7679394 codY Streptococcus pneumoniae JJA transcriptional repressor CodY YP_002736537.1 1415636 R 488222 CDS YP_002736538.1 225855026 7678403 complement(1416689..1418263) 1 NC_012466.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; ATP-dependent RNA helicase, DEAD/DEAH box family 1418263 7678403 SPJ_1491 Streptococcus pneumoniae JJA ATP-dependent RNA helicase, DEAD/DEAH box family YP_002736538.1 1416689 R 488222 CDS YP_002736539.1 225855027 7680361 complement(1418462..1419688) 1 NC_012466.1 identified by match to protein family HMM PF07690; major facilitator:Oxalate:Formate Antiporter 1419688 7680361 SPJ_1492 Streptococcus pneumoniae JJA major facilitator:Oxalate:Formate Antiporter YP_002736539.1 1418462 R 488222 CDS YP_002736540.1 225855028 7679955 1419881..1421197 1 NC_012466.1 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 1421197 7679955 SPJ_1493 Streptococcus pneumoniae JJA pyridine nucleotide-disulfide oxidoreductase YP_002736540.1 1419881 D 488222 CDS YP_002736541.1 225855029 7679304 1421296..1422639 1 NC_012466.1 identified by match to protein family HMM PF08245; match to protein family HMM PF08353; Mur ligase family protein 1422639 7679304 SPJ_1494 Streptococcus pneumoniae JJA Mur ligase family protein YP_002736541.1 1421296 D 488222 CDS YP_002736542.1 225855030 7678678 1422639..1423421 1 NC_012466.1 identified by match to protein family HMM PF07685; cobyric acid synthase 1423421 7678678 SPJ_1495 Streptococcus pneumoniae JJA cobyric acid synthase YP_002736542.1 1422639 D 488222 CDS YP_002736543.1 225855031 7678597 1423547..1424629 1 NC_012466.1 identified by match to protein family HMM PF00557; match to protein family HMM PF01321; Xaa-Pro dipeptidase (X-Pro dipeptidase) (Prolinedipeptidase) (Prolidase) (Imidodipeptidase) 1424629 7678597 SPJ_1496 Streptococcus pneumoniae JJA Xaa-Pro dipeptidase (X-Pro dipeptidase) (Prolinedipeptidase) (Prolidase) (Imidodipeptidase) YP_002736543.1 1423547 D 488222 CDS YP_002736544.1 225855032 7680295 1424679..1424825 1 NC_012466.1 acetyltransferase, gnat family 1424825 7680295 SPJ_1497 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002736544.1 1424679 D 488222 CDS YP_002736545.1 225855033 7680507 complement(1424953..1425786) 1 NC_012466.1 identified by match to protein family HMM PF00665; integrase core domain protein 1425786 7680507 SPJ_1498 Streptococcus pneumoniae JJA integrase core domain protein YP_002736545.1 1424953 R 488222 CDS YP_002736546.1 225855034 7678827 complement(1425779..1425946) 1 NC_012466.1 hypothetical protein 1425946 7678827 SPJ_1499 Streptococcus pneumoniae JJA hypothetical protein YP_002736546.1 1425779 R 488222 CDS YP_002736547.1 225855035 7678500 complement(1426082..1426294) 1 NC_012466.1 transposase 1426294 7678500 SPJ_1500 Streptococcus pneumoniae JJA transposase YP_002736547.1 1426082 R 488222 CDS YP_002736548.1 225855036 7678968 complement(1426521..1426982) 1 NC_012466.1 hypothetical protein 1426982 7678968 SPJ_1501 Streptococcus pneumoniae JJA hypothetical protein YP_002736548.1 1426521 R 488222 CDS YP_002736549.1 225855037 7678449 complement(1426960..1427733) 1 NC_012466.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 1427733 7678449 SPJ_1502 Streptococcus pneumoniae JJA phosphomethylpyrimidine kinase YP_002736549.1 1426960 R 488222 CDS YP_002736550.1 225855038 7679031 complement(1427723..1428472) 1 NC_012466.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1428472 truA 7679031 truA Streptococcus pneumoniae JJA tRNA pseudouridine synthase A YP_002736550.1 1427723 R 488222 CDS YP_002736551.1 225855039 7679673 1428652..1428813 1 NC_012466.1 hypothetical protein 1428813 7679673 SPJ_1505 Streptococcus pneumoniae JJA hypothetical protein YP_002736551.1 1428652 D 488222 CDS YP_002736552.1 225855040 7678664 complement(1428785..1429936) 1 NC_012466.1 identified by match to protein family HMM PF07690; major facilitator superfamily transporter 1429936 7678664 SPJ_1504 Streptococcus pneumoniae JJA major facilitator superfamily transporter YP_002736552.1 1428785 R 488222 CDS YP_002736553.1 225855041 7680271 1429908..1430024 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1430024 7680271 SPJ_1506 Streptococcus pneumoniae JJA hypothetical protein YP_002736553.1 1429908 D 488222 CDS YP_002736554.1 225855042 7679410 complement(1430176..1430805) 1 NC_012466.1 hypothetical protein 1430805 7679410 SPJ_1507 Streptococcus pneumoniae JJA hypothetical protein YP_002736554.1 1430176 R 488222 CDS YP_002736555.1 225855043 7679818 complement(1430808..1431146) 1 NC_012466.1 identified by match to protein family HMM PF03831; match to protein family HMM PF08274; match to protein family HMM TIGR00686; alkylphosphonate utilization operon protein PhnA 1431146 phnA 7679818 phnA Streptococcus pneumoniae JJA alkylphosphonate utilization operon protein PhnA YP_002736555.1 1430808 R 488222 CDS YP_002736556.1 225855044 7680306 complement(1431277..1431948) 1 NC_012466.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1431948 cmk 7680306 cmk Streptococcus pneumoniae JJA cytidylate kinase YP_002736556.1 1431277 R 488222 CDS YP_002736557.1 225855045 7679864 complement(1431957..1432433) 1 NC_012466.1 hypothetical protein 1432433 7679864 SPJ_1510 Streptococcus pneumoniae JJA hypothetical protein YP_002736557.1 1431957 R 488222 CDS YP_002736558.1 225855046 7680511 1432479..1432691 1 NC_012466.1 ferredoxin 1432691 7680511 SPJ_1511 Streptococcus pneumoniae JJA ferredoxin YP_002736558.1 1432479 D 488222 CDS YP_002736559.1 225855047 7678795 complement(1432753..1433706) 1 NC_012466.1 identified by match to protein family HMM PF00535; bactoprenol glucosyl transferase 1433706 7678795 SPJ_1512 Streptococcus pneumoniae JJA bactoprenol glucosyl transferase YP_002736559.1 1432753 R 488222 CDS YP_002736560.1 225855048 7679002 complement(1433708..1434727) 1 NC_012466.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase 1434727 galE1 7679002 galE1 Streptococcus pneumoniae JJA UDP-glucose 4-epimerase YP_002736560.1 1433708 R 488222 CDS YP_002736561.1 225855049 7679496 complement(1434830..1434958) 1 NC_012466.1 chlorohydrolase 1434958 7679496 SPJ_1514 Streptococcus pneumoniae JJA chlorohydrolase YP_002736561.1 1434830 R 488222 CDS YP_002736562.1 225855050 7680248 complement(1435028..1436131) 1 NC_012466.1 identified by match to protein family HMM PF01266; FAD dependent oxidoreductase 1436131 7680248 SPJ_1515 Streptococcus pneumoniae JJA FAD dependent oxidoreductase YP_002736562.1 1435028 R 488222 CDS YP_002736563.1 225855051 7678570 complement(1436148..1436945) 1 NC_012466.1 identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486; hypothetical protein 1436945 7678570 SPJ_1516 Streptococcus pneumoniae JJA hypothetical protein YP_002736563.1 1436148 R 488222 CDS YP_002736564.1 225855052 7679887 complement(1436932..1437609) 1 NC_012466.1 identified by match to protein family HMM PF04816; Bcl-2 family protein 1437609 7679887 SPJ_1517 Streptococcus pneumoniae JJA Bcl-2 family protein YP_002736564.1 1436932 R 488222 CDS YP_002736565.1 225855053 7679471 complement(1437711..1440047) 1 NC_012466.1 identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; P-type ATPase - metal cation transport 1440047 7679471 SPJ_1518 Streptococcus pneumoniae JJA P-type ATPase - metal cation transport YP_002736565.1 1437711 R 488222 CDS YP_002736566.1 225855054 7679849 1440180..1440929 1 NC_012466.1 identified by match to protein family HMM PF01553; acyltransferase family protein 1440929 7679849 SPJ_1519 Streptococcus pneumoniae JJA acyltransferase family protein YP_002736566.1 1440180 D 488222 CDS YP_002736567.1 225855055 7680313 complement(1441221..1441835) 1 NC_012466.1 identified by match to protein family HMM PF03596; match to protein family HMM TIGR00779; CadD 1441835 7680313 SPJ_1520 Streptococcus pneumoniae JJA CadD YP_002736567.1 1441221 R 488222 CDS YP_002736568.1 225855056 7679842 complement(1442650..1442919) 1 NC_012466.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1442919 rpsO 7679842 rpsO Streptococcus pneumoniae JJA 30S ribosomal protein S15 YP_002736568.1 1442650 R 488222 CDS YP_002736569.1 225855057 7680369 complement(1443060..1443689) 1 NC_012466.1 YwnB 1443689 7680369 SPJ_1522 Streptococcus pneumoniae JJA YwnB YP_002736569.1 1443060 R 488222 CDS YP_002736570.1 225855058 7679174 1444558..1444881 1 NC_012466.1 hypothetical protein 1444881 7679174 SPJ_1523 Streptococcus pneumoniae JJA hypothetical protein YP_002736570.1 1444558 D 488222 CDS YP_002736571.1 225855059 7679606 1444939..1446882 1 NC_012466.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1446882 thrS 7679606 thrS Streptococcus pneumoniae JJA threonyl-tRNA synthetase YP_002736571.1 1444939 D 488222 CDS YP_002736572.1 225855060 7680092 complement(1446931..1447905) 1 NC_012466.1 identified by match to protein family HMM PF02518; histidine kinase 1447905 7680092 SPJ_1525 Streptococcus pneumoniae JJA histidine kinase YP_002736572.1 1446931 R 488222 CDS YP_002736573.1 225855061 7678929 complement(1447898..1448575) 1 NC_012466.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator 1448575 7678929 SPJ_1526 Streptococcus pneumoniae JJA response regulator YP_002736573.1 1447898 R 488222 CDS YP_002736574.1 225855062 7679352 1448731..1449804 1 NC_012466.1 hypothetical protein 1449804 7679352 SPJ_1527 Streptococcus pneumoniae JJA hypothetical protein YP_002736574.1 1448731 D 488222 CDS YP_002736575.1 225855063 7678600 complement(1449895..1450197) 1 NC_012466.1 hypothetical protein 1450197 7678600 SPJ_1528 Streptococcus pneumoniae JJA hypothetical protein YP_002736575.1 1449895 R 488222 CDS YP_002736576.1 225855064 7679087 complement(1450265..1450702) 1 NC_012466.1 identified by match to protein family HMM PF02082; Rrf2 family protein 1450702 7679087 SPJ_1529 Streptococcus pneumoniae JJA Rrf2 family protein YP_002736576.1 1450265 R 488222 CDS YP_002736577.1 225855065 7678640 complement(1450778..1451620) 1 NC_012466.1 identified by match to protein family HMM PF00149; metallophosphoesterase 1451620 7678640 SPJ_1530 Streptococcus pneumoniae JJA metallophosphoesterase YP_002736577.1 1450778 R 488222 CDS YP_002736578.1 225855066 7680340 1451732..1452382 1 NC_012466.1 identified by match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF02742; match to protein family HMM PF04023; iron-dependent transcriptional regulator 1452382 7680340 SPJ_1531 Streptococcus pneumoniae JJA iron-dependent transcriptional regulator YP_002736578.1 1451732 D 488222 CDS YP_002736579.1 225855067 7679890 1452363..1452497 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1452497 7679890 SPJ_1532 Streptococcus pneumoniae JJA hypothetical protein YP_002736579.1 1452363 D 488222 CDS YP_002736580.1 225855068 7679442 1452706..1453227 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1453227 7679442 SPJ_1533 Streptococcus pneumoniae JJA hypothetical protein YP_002736580.1 1452706 D 488222 CDS YP_002736581.1 225855069 7678903 1453358..1453795 1 NC_012466.1 hypothetical protein 1453795 7678903 SPJ_1534 Streptococcus pneumoniae JJA hypothetical protein YP_002736581.1 1453358 D 488222 CDS YP_002736582.1 225855070 7678475 complement(1453890..1454189) 1 NC_012466.1 hypothetical protein 1454189 7678475 SPJ_1535 Streptococcus pneumoniae JJA hypothetical protein YP_002736582.1 1453890 R 488222 CDS YP_002736583.1 225855071 7680187 1455318..1455431 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1455431 7680187 SPJ_1536 Streptococcus pneumoniae JJA hypothetical protein YP_002736583.1 1455318 D 488222 CDS YP_002736584.1 225855072 7678390 1455571..1455732 1 NC_012466.1 hypothetical protein 1455732 7678390 SPJ_1537 Streptococcus pneumoniae JJA hypothetical protein YP_002736584.1 1455571 D 488222 CDS YP_002736585.1 225855073 7679872 complement(1455771..1456214) 1 NC_012466.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 1456214 dtd 7679872 dtd Streptococcus pneumoniae JJA D-tyrosyl-tRNA(Tyr) deacylase YP_002736585.1 1455771 R 488222 CDS YP_002736586.1 225855074 7678465 complement(1456244..1458466) 1 NC_012466.1 identified by match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691; guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase 1458466 spoT 7678465 spoT Streptococcus pneumoniae JJA guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase YP_002736586.1 1456244 R 488222 CDS YP_002736587.1 225855075 7678794 1458877..1459119 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1459119 7678794 SPJ_1540 Streptococcus pneumoniae JJA hypothetical protein YP_002736587.1 1458877 D 488222 CDS YP_002736588.1 225855076 7679208 1459459..1460088 1 NC_012466.1 identified by match to protein family HMM PF00753; metallo-beta-lactamase superfamily protein 1460088 7679208 SPJ_1541 Streptococcus pneumoniae JJA metallo-beta-lactamase superfamily protein YP_002736588.1 1459459 D 488222 CDS YP_002736589.1 225855077 7678440 complement(1460211..1462103) 1 NC_012466.1 identified by match to protein family HMM PF01431; match to protein family HMM PF05649; endopeptidase O 1462103 7678440 SPJ_1542 Streptococcus pneumoniae JJA endopeptidase O YP_002736589.1 1460211 R 488222 CDS YP_002736590.1 225855078 7680399 1462394..1463116 1 NC_012466.1 identified by match to protein family HMM PF00005; manganese transport system ATP-binding protein MntA 1463116 7680399 SPJ_1543 Streptococcus pneumoniae JJA manganese transport system ATP-binding protein MntA YP_002736590.1 1462394 D 488222 CDS YP_002736591.1 225855079 7679812 1463113..1463961 1 NC_012466.1 identified by match to protein family HMM PF00950; manganese transport system membrane protein MntB 1463961 7679812 SPJ_1544 Streptococcus pneumoniae JJA manganese transport system membrane protein MntB YP_002736591.1 1463113 D 488222 CDS YP_002736592.1 225855080 7679944 1463993..1464922 1 NC_012466.1 identified by match to protein family HMM PF01297; manganese ABC transporter substrate-binding lipoprotein (Adhesin B) (Saliva-binding protein) 1464922 7679944 SPJ_1545 Streptococcus pneumoniae JJA manganese ABC transporter substrate-binding lipoprotein (Adhesin B) (Saliva-binding protein) YP_002736592.1 1463993 D 488222 CDS YP_002736593.1 225855081 7679347 1465045..1465536 1 NC_012466.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1465536 tpx 7679347 tpx Streptococcus pneumoniae JJA thiol peroxidase YP_002736593.1 1465045 D 488222 CDS YP_002736594.1 225855082 7680071 1465587..1465718 1 NC_012466.1 DNA alkylation repair enzyme 1465718 7680071 SPJ_1547 Streptococcus pneumoniae JJA DNA alkylation repair enzyme YP_002736594.1 1465587 D 488222 CDS YP_002736595.1 225855083 7679688 complement(1465744..1468452) 1 NC_012466.1 identified by match to protein family HMM PF02687; efflux ABC transporter, permease protein 1468452 7679688 SPJ_1548 Streptococcus pneumoniae JJA efflux ABC transporter, permease protein YP_002736595.1 1465744 R 488222 CDS YP_002736596.1 225855084 7680197 complement(1468454..1469155) 1 NC_012466.1 identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease protein MacB 1469155 7680197 SPJ_1549 Streptococcus pneumoniae JJA macrolide export ATP-binding/permease protein MacB YP_002736596.1 1468454 R 488222 CDS YP_002736597.1 225855085 7679650 complement(1469286..1471697) 1 NC_012466.1 alpha-fucosidase 1471697 7679650 SPJ_1550 Streptococcus pneumoniae JJA alpha-fucosidase YP_002736597.1 1469286 R 488222 CDS YP_002736598.1 225855086 7679433 complement(1471750..1472442) 1 NC_012466.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 1472442 gpmA 7679433 gpmA Streptococcus pneumoniae JJA phosphoglyceromutase YP_002736598.1 1471750 R 488222 CDS YP_002736599.1 225855087 7678510 complement(1472493..1472681) 1 NC_012466.1 hypothetical protein 1472681 7678510 SPJ_1552 Streptococcus pneumoniae JJA hypothetical protein YP_002736599.1 1472493 R 488222 CDS YP_002736600.1 225855088 7680394 complement(1472977..1473339) 1 NC_012466.1 integral membrane protein 1473339 7680394 SPJ_1553 Streptococcus pneumoniae JJA integral membrane protein YP_002736600.1 1472977 R 488222 CDS YP_002736601.1 225855089 7679934 complement(1473749..1476541) 1 NC_012466.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1476541 ileS 7679934 ileS Streptococcus pneumoniae JJA isoleucyl-tRNA synthetase YP_002736601.1 1473749 R 488222 CDS YP_002736602.1 225855090 7679741 complement(1476794..1476910) 1 NC_012466.1 hypothetical protein 1476910 7679741 SPJ_1555 Streptococcus pneumoniae JJA hypothetical protein YP_002736602.1 1476794 R 488222 CDS YP_002736603.1 225855091 7678704 complement(1476889..1477677) 1 NC_012466.1 identified by match to protein family HMM PF05103; cell-division initiation protein 1477677 7678704 SPJ_1556 Streptococcus pneumoniae JJA cell-division initiation protein YP_002736603.1 1476889 R 488222 CDS YP_002736604.1 225855092 7679985 complement(1477686..1478471) 1 NC_012466.1 identified by match to protein family HMM PF01479; YlmH protein 1478471 7679985 SPJ_1557 Streptococcus pneumoniae JJA YlmH protein YP_002736604.1 1477686 R 488222 CDS YP_002736605.1 225855093 7680520 complement(1478468..1478731) 1 NC_012466.1 identified by match to protein family HMM PF02325; yggt family, putative 1478731 7680520 SPJ_1558 Streptococcus pneumoniae JJA yggt family, putative YP_002736605.1 1478468 R 488222 CDS YP_002736606.1 225855094 7679540 complement(1478731..1479270) 1 NC_012466.1 identified by match to protein family HMM PF04472; YlmF protein 1479270 7679540 SPJ_1559 Streptococcus pneumoniae JJA YlmF protein YP_002736606.1 1478731 R 488222 CDS YP_002736607.1 225855095 7679059 complement(1479280..1479951) 1 NC_012466.1 identified by match to protein family HMM TIGR00044; pyridoxal phosphate enzyme, YggS family 1479951 7679059 SPJ_1560 Streptococcus pneumoniae JJA pyridoxal phosphate enzyme, YggS family YP_002736607.1 1479280 R 488222 CDS YP_002736608.1 225855096 7678943 complement(1479956..1481215) 1 NC_012466.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1481215 ftsZ 7678943 ftsZ Streptococcus pneumoniae JJA cell division protein FtsZ YP_002736608.1 1479956 R 488222 CDS YP_002736609.1 225855097 7678592 complement(1481232..1482605) 1 NC_012466.1 identified by match to protein family HMM PF02491; match to protein family HMM TIGR01174; cell division protein FtsA 1482605 ftsA 7678592 ftsA Streptococcus pneumoniae JJA cell division protein FtsA YP_002736609.1 1481232 R 488222 CDS YP_002736610.1 225855098 7680220 complement(1482824..1483528) 1 NC_012466.1 identified by match to protein family HMM TIGR02206; hypothetical protein 1483528 7680220 SPJ_1563 Streptococcus pneumoniae JJA hypothetical protein YP_002736610.1 1482824 R 488222 CDS YP_002736611.1 225855099 7679335 complement(1483619..1484230) 1 NC_012466.1 identified by match to protein family HMM PF00293; mutator protein 1484230 7679335 SPJ_1564 Streptococcus pneumoniae JJA mutator protein YP_002736611.1 1483619 R 488222 CDS YP_002736612.1 225855100 7679337 complement(1484217..1485590) 1 NC_012466.1 identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01143; UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D- alanyl-D-alanine ligase 1485590 7679337 SPJ_1565 Streptococcus pneumoniae JJA UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D- alanyl-D-alanine ligase YP_002736612.1 1484217 R 488222 CDS YP_002736613.1 225855101 7678708 complement(1485674..1486717) 1 NC_012466.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 1486717 ddl 7678708 ddl Streptococcus pneumoniae JJA D-alanyl-alanine synthetase A YP_002736613.1 1485674 R 488222 CDS YP_002736614.1 225855102 7680474 complement(1486893..1487489) 1 NC_012466.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1487489 recR 7680474 recR Streptococcus pneumoniae JJA recombination protein RecR YP_002736614.1 1486893 R 488222 CDS YP_002736615.1 225855103 7678882 complement(1487500..1489542) 1 NC_012466.1 identified by match to protein family HMM PF00905; match to protein family HMM PF03717; penicillin-binding protein 2B 1489542 7678882 SPJ_1568 Streptococcus pneumoniae JJA penicillin-binding protein 2B YP_002736615.1 1487500 R 488222 CDS YP_002736616.1 225855104 7679573 1489757..1490608 1 NC_012466.1 identified by match to protein family HMM PF01380; match to protein family HMM PF01418; transcriptional regulator, RpiR family 1490608 7679573 SPJ_1569 Streptococcus pneumoniae JJA transcriptional regulator, RpiR family YP_002736616.1 1489757 D 488222 CDS YP_002736617.1 225855105 7679200 complement(1490624..1491508) 1 NC_012466.1 identified by match to protein family HMM PF00480; glucokinase 1491508 7679200 SPJ_1570 Streptococcus pneumoniae JJA glucokinase YP_002736617.1 1490624 R 488222 CDS YP_002736618.1 225855106 7680319 complement(1491526..1492443) 1 NC_012466.1 identified by match to protein family HMM PF00701; N-acetylneuraminate lyase 1492443 7680319 SPJ_1571 Streptococcus pneumoniae JJA N-acetylneuraminate lyase YP_002736618.1 1491526 R 488222 CDS YP_002736619.1 225855107 7679865 complement(1492612..1493256) 1 NC_012466.1 identified by match to protein family HMM PF04854; hypothetical protein 1493256 7679865 SPJ_1572 Streptococcus pneumoniae JJA hypothetical protein YP_002736619.1 1492612 R 488222 CDS YP_002736620.1 225855108 7679861 complement(1493543..1493677) 1 NC_012466.1 hypothetical protein 1493677 7679861 SPJ_1573 Streptococcus pneumoniae JJA hypothetical protein YP_002736620.1 1493543 R 488222 CDS YP_002736621.1 225855109 7679353 complement(1493984..1494436) 1 NC_012466.1 identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 1494436 7679353 SPJ_1574 Streptococcus pneumoniae JJA hypothetical protein YP_002736621.1 1493984 R 488222 CDS YP_002736622.1 225855110 7678870 complement(1494708..1495547) 1 NC_012466.1 identified by match to protein family HMM PF00528; sugar ABC transporter permease 1495547 7678870 SPJ_1575 Streptococcus pneumoniae JJA sugar ABC transporter permease YP_002736622.1 1494708 R 488222 CDS YP_002736623.1 225855111 7680179 complement(1495563..1496450) 1 NC_012466.1 identified by match to protein family HMM PF00528; sugar ABC transporter permease 1496450 7680179 SPJ_1576 Streptococcus pneumoniae JJA sugar ABC transporter permease YP_002736623.1 1495563 R 488222 CDS YP_002736624.1 225855112 7678710 complement(1496681..1498009) 1 NC_012466.1 identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein 1498009 7678710 SPJ_1577 Streptococcus pneumoniae JJA sugar ABC transporter substrate-binding protein YP_002736624.1 1496681 R 488222 CDS YP_002736625.1 225855113 7680287 complement(1498134..1499651) 1 NC_012466.1 identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; pts system maltose- and glucose-specific eiicb component 1499651 7680287 SPJ_1578 Streptococcus pneumoniae JJA pts system maltose- and glucose-specific eiicb component YP_002736625.1 1498134 R 488222 CDS YP_002736626.1 225855114 7680497 complement(1499670..1500368) 1 NC_012466.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 1500368 7680497 SPJ_1579 Streptococcus pneumoniae JJA N-acetylmannosamine-6-phosphate 2-epimerase YP_002736626.1 1499670 R 488222 CDS YP_002736627.1 225855115 7678661 complement(1500542..1501645) 1 NC_012466.1 identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; match to protein family HMM PF03447; putative oxidoreductase YjhC 1501645 7678661 SPJ_1580 Streptococcus pneumoniae JJA putative oxidoreductase YjhC YP_002736627.1 1500542 R 488222 CDS YP_002736628.1 225855116 7679000 complement(1501657..1503750) 1 NC_012466.1 identified by match to protein family HMM PF02012; match to protein family HMM PF02973; sialidase B (Neuraminidase B) 1503750 7679000 SPJ_1581 Streptococcus pneumoniae JJA sialidase B (Neuraminidase B) YP_002736628.1 1501657 R 488222 CDS YP_002736629.1 225855117 7679922 complement(1503768..1504601) 1 NC_012466.1 identified by match to protein family HMM PF00528; ABC transporter permease 1504601 7679922 SPJ_1582 Streptococcus pneumoniae JJA ABC transporter permease YP_002736629.1 1503768 R 488222 CDS YP_002736630.1 225855118 7680276 complement(1504601..1505485) 1 NC_012466.1 identified by match to protein family HMM PF00528; ABC transporter permease 1505485 7680276 SPJ_1583 Streptococcus pneumoniae JJA ABC transporter permease YP_002736630.1 1504601 R 488222 CDS YP_002736631.1 225855119 7678426 complement(1505564..1506901) 1 NC_012466.1 identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein 1506901 7678426 SPJ_1584 Streptococcus pneumoniae JJA sugar ABC transporter substrate-binding protein YP_002736631.1 1505564 R 488222 CDS YP_002736632.1 225855120 7678694 complement(1506920..1507372) 1 NC_012466.1 identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 1507372 7678694 SPJ_1585 Streptococcus pneumoniae JJA hypothetical protein YP_002736632.1 1506920 R 488222 CDS YP_002736633.1 225855121 7679311 complement(1508386..1511214) 1 NC_012466.1 identified by match to protein family HMM PF02012; match to protein family HMM PF02973; match to protein family HMM TIGR01167; neuraminidase 1511214 7679311 SPJ_1586 Streptococcus pneumoniae JJA neuraminidase YP_002736633.1 1508386 R 488222 CDS YP_002736634.1 225855122 7680021 complement(1511571..1511798) 1 NC_012466.1 hypothetical protein 1511798 7680021 SPJ_1587 Streptococcus pneumoniae JJA hypothetical protein YP_002736634.1 1511571 R 488222 CDS YP_002736635.1 225855123 7679076 1512196..1512609 1 NC_012466.1 hypothetical protein 1512609 7679076 SPJ_1588 Streptococcus pneumoniae JJA hypothetical protein YP_002736635.1 1512196 D 488222 CDS YP_002736636.1 225855124 7678914 complement(1512963..1513943) 1 NC_012466.1 identified by match to protein family HMM PF05448; xylan esterase 1 1513943 7678914 SPJ_1589 Streptococcus pneumoniae JJA xylan esterase 1 YP_002736636.1 1512963 R 488222 CDS YP_002736637.1 225855125 7680529 complement(1514260..1516275) 1 NC_012466.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 1516275 recG 7680529 recG Streptococcus pneumoniae JJA ATP-dependent DNA helicase RecG YP_002736637.1 1514260 R 488222 CDS YP_002736638.1 225855126 7679843 complement(1516294..1517397) 1 NC_012466.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 1517397 alr 7679843 alr Streptococcus pneumoniae JJA alanine racemase YP_002736638.1 1516294 R 488222 CDS YP_002736639.1 225855127 7679370 complement(1517387..1517749) 1 NC_012466.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1517749 acpS 7679370 acpS Streptococcus pneumoniae JJA 4'-phosphopantetheinyl transferase YP_002736639.1 1517387 R 488222 CDS YP_002736640.1 225855128 7679743 complement(1517794..1518825) 1 NC_012466.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1518825 7679743 SPJ_1593 Streptococcus pneumoniae JJA phospho-2-dehydro-3-deoxyheptonate aldolase YP_002736640.1 1517794 R 488222 CDS YP_002736641.1 225855129 7680414 complement(1518827..1519858) 1 NC_012466.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1519858 7680414 SPJ_1594 Streptococcus pneumoniae JJA phospho-2-dehydro-3-deoxyheptonate aldolase YP_002736641.1 1518827 R 488222 CDS YP_002736642.1 225855130 7678529 complement(1519939..1522452) 1 NC_012466.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1522452 secA 7678529 secA Streptococcus pneumoniae JJA preprotein translocase subunit SecA YP_002736642.1 1519939 R 488222 CDS YP_002736643.1 225855131 7679151 complement(1522598..1522885) 1 NC_012466.1 hypothetical protein 1522885 7679151 SPJ_1596 Streptococcus pneumoniae JJA hypothetical protein YP_002736643.1 1522598 R 488222 CDS YP_002736644.1 225855132 7679271 complement(1522913..1523545) 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1523545 7679271 SPJ_1597 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002736644.1 1522913 R 488222 CDS YP_002736645.1 225855133 7678684 complement(1523549..1524190) 1 NC_012466.1 hypothetical protein 1524190 7678684 SPJ_1598 Streptococcus pneumoniae JJA hypothetical protein YP_002736645.1 1523549 R 488222 CDS YP_002736646.1 225855134 7679323 complement(1524183..1524974) 1 NC_012466.1 hypothetical protein 1524974 7679323 SPJ_1599 Streptococcus pneumoniae JJA hypothetical protein YP_002736646.1 1524183 R 488222 CDS YP_002736647.1 225855135 7679935 complement(1524996..1525388) 1 NC_012466.1 hypothetical protein 1525388 7679935 SPJ_1600 Streptococcus pneumoniae JJA hypothetical protein YP_002736647.1 1524996 R 488222 CDS YP_002736648.1 225855136 7680462 1525715..1526566 1 NC_012466.1 identified by match to protein family HMM PF01381; match to protein family HMM TIGR01716; transcriptional activator, Rgg/GadR/MutR family, C- domain protein 1526566 7680462 SPJ_1601 Streptococcus pneumoniae JJA transcriptional activator, Rgg/GadR/MutR family, C- domain protein YP_002736648.1 1525715 D 488222 CDS YP_002736649.1 225855137 7678520 complement(1526798..1527148) 1 NC_012466.1 hypothetical protein 1527148 7678520 SPJ_1602 Streptococcus pneumoniae JJA hypothetical protein YP_002736649.1 1526798 R 488222 CDS YP_002736650.1 225855138 7679198 complement(1527288..1527623) 1 NC_012466.1 hypothetical protein 1527623 7679198 SPJ_1603 Streptococcus pneumoniae JJA hypothetical protein YP_002736650.1 1527288 R 488222 CDS YP_002736651.1 225855139 7679515 complement(1527711..1529021) 1 NC_012466.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1529021 engA 7679515 engA Streptococcus pneumoniae JJA GTP-binding protein EngA YP_002736651.1 1527711 R 488222 CDS YP_002736652.1 225855140 7679783 complement(1529035..1529748) 1 NC_012466.1 identified by match to protein family HMM PF00881; nitroreductase family protein 1529748 7679783 SPJ_1605 Streptococcus pneumoniae JJA nitroreductase family protein YP_002736652.1 1529035 R 488222 CDS YP_002736653.1 225855141 7678569 complement(1529745..1530641) 1 NC_012466.1 Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI 1530641 7678569 SPJ_1606 Streptococcus pneumoniae JJA primosomal protein DnaI YP_002736653.1 1529745 R 488222 CDS YP_002736654.1 225855142 7678920 complement(1530642..1531811) 1 NC_012466.1 identified by match to protein family HMM PF07261; replication initiation and membrane attachment protein 1531811 7678920 SPJ_1607 Streptococcus pneumoniae JJA replication initiation and membrane attachment protein YP_002736654.1 1530642 R 488222 CDS YP_002736655.1 225855143 7679473 complement(1531812..1532285) 1 NC_012466.1 identified by match to protein family HMM PF03477; match to protein family HMM TIGR00244; transcriptional regulator NrdR 1532285 nrdR 7679473 nrdR Streptococcus pneumoniae JJA transcriptional regulator NrdR YP_002736655.1 1531812 R 488222 CDS YP_002736656.1 225855144 7678848 1532425..1532790 1 NC_012466.1 identified by match to protein family HMM PF00392; GntR family transcriptional regulator 1532790 7678848 SPJ_1609 Streptococcus pneumoniae JJA GntR family transcriptional regulator YP_002736656.1 1532425 D 488222 CDS YP_002736657.1 225855145 7680407 1532795..1533490 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1533490 7680407 SPJ_1610 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002736657.1 1532795 D 488222 CDS YP_002736658.1 225855146 7680273 1533507..1534274 1 NC_012466.1 ABC transporter ATP-binding protein 1534274 7680273 SPJ_1611 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002736658.1 1533507 D 488222 CDS YP_002736659.1 225855147 7680518 complement(1534627..1535826) 1 NC_012466.1 Na+ ABC transporter permease 1535826 7680518 SPJ_1612 Streptococcus pneumoniae JJA Na+ ABC transporter permease YP_002736659.1 1534627 R 488222 CDS YP_002736660.1 225855148 7679062 complement(1535823..1536716) 1 NC_012466.1 identified by match to protein family HMM PF00005; Na+ ABC transporter ATP-binding protein 1536716 7679062 SPJ_1613 Streptococcus pneumoniae JJA Na+ ABC transporter ATP-binding protein YP_002736660.1 1535823 R 488222 CDS YP_002736661.1 225855149 7678596 1536839..1537030 1 NC_012466.1 chlorohydrolase 1537030 7678596 SPJ_1614 Streptococcus pneumoniae JJA chlorohydrolase YP_002736661.1 1536839 D 488222 CDS YP_002736662.1 225855150 7680314 1538026..1538643 1 NC_012466.1 identified by match to protein family HMM PF09335; hypothetical protein 1538643 7680314 SPJ_1615 Streptococcus pneumoniae JJA hypothetical protein YP_002736662.1 1538026 D 488222 CDS YP_002736663.1 225855151 7679824 complement(1538963..1539850) 1 NC_012466.1 identified by match to protein family HMM PF00480; fructokinase 1539850 7679824 SPJ_1616 Streptococcus pneumoniae JJA fructokinase YP_002736663.1 1538963 R 488222 CDS YP_002736664.1 225855152 7678626 complement(1539999..1541882) 1 NC_012466.1 identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01996; pts system, sucrose-specific iibc component 1541882 7678626 SPJ_1617 Streptococcus pneumoniae JJA pts system, sucrose-specific iibc component YP_002736664.1 1539999 R 488222 CDS YP_002736665.1 225855153 7679560 complement(1542009..1542206) 1 NC_012466.1 hypothetical protein 1542206 7679560 SPJ_1618 Streptococcus pneumoniae JJA hypothetical protein YP_002736665.1 1542009 R 488222 CDS YP_002736666.1 225855154 7679110 1542259..1543713 1 NC_012466.1 identified by match to protein family HMM PF00251; match to protein family HMM PF08244; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase (Sucrase) (Invertase) 1543713 7679110 SPJ_1619 Streptococcus pneumoniae JJA sucrose-6-phosphate hydrolase (Sucrase) (Invertase) YP_002736666.1 1542259 D 488222 CDS YP_002736667.1 225855155 7678601 1543694..1544659 1 NC_012466.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sucrose operon repressor (Scr operon regulatory protein) 1544659 7678601 SPJ_1620 Streptococcus pneumoniae JJA sucrose operon repressor (Scr operon regulatory protein) YP_002736667.1 1543694 D 488222 CDS YP_002736668.1 225855156 7679145 complement(1544694..1545968) 1 NC_012466.1 identified by match to protein family HMM TIGR00532; hydroxymethylglutaryl-CoA reductase, degradative 1545968 7679145 SPJ_1621 Streptococcus pneumoniae JJA hydroxymethylglutaryl-CoA reductase, degradative YP_002736668.1 1544694 R 488222 CDS YP_002736669.1 225855157 7678544 complement(1545968..1547164) 1 NC_012466.1 identified by match to protein family HMM PF01154; match to protein family HMM PF08540; match to protein family HMM TIGR01835; hydroxymethylglutaryl-CoA synthase 1547164 7678544 SPJ_1622 Streptococcus pneumoniae JJA hydroxymethylglutaryl-CoA synthase YP_002736669.1 1545968 R 488222 CDS YP_002736670.1 225855158 7680484 complement(1547271..1547519) 1 NC_012466.1 hypothetical protein 1547519 7680484 SPJ_1623 Streptococcus pneumoniae JJA hypothetical protein YP_002736670.1 1547271 R 488222 CDS YP_002736671.1 225855159 7679784 complement(1547587..1548054) 1 NC_012466.1 identified by match to protein family HMM PF01609; transposase (IS4 family) 1548054 7679784 SPJ_1624 Streptococcus pneumoniae JJA transposase (IS4 family) YP_002736671.1 1547587 R 488222 CDS YP_002736672.1 225855160 7678454 complement(1548002..1548115) 1 NC_012466.1 tranposase 1548115 7678454 SPJ_1625 Streptococcus pneumoniae JJA tranposase YP_002736672.1 1548002 R 488222 CDS YP_002736673.1 225855161 7678927 complement(1548274..1548723) 1 NC_012466.1 hypothetical protein 1548723 7678927 SPJ_1626 Streptococcus pneumoniae JJA hypothetical protein YP_002736673.1 1548274 R 488222 CDS YP_002736674.1 225855162 7679706 complement(1548725..1549483) 1 NC_012466.1 identified by match to protein family HMM PF06738; hypothetical protein 1549483 7679706 SPJ_1627 Streptococcus pneumoniae JJA hypothetical protein YP_002736674.1 1548725 R 488222 CDS YP_002736675.1 225855163 7680284 complement(1549598..1551577) 1 NC_012466.1 identified by match to protein family HMM PF00069; match to protein family HMM PF01163; match to protein family HMM PF03793; Stk1 1551577 7680284 SPJ_1628 Streptococcus pneumoniae JJA Stk1 YP_002736675.1 1549598 R 488222 CDS YP_002736676.1 225855164 7680540 complement(1551574..1552314) 1 NC_012466.1 identified by match to protein family HMM PF00481; protein phosphatase PrpC 1552314 7680540 SPJ_1629 Streptococcus pneumoniae JJA protein phosphatase PrpC YP_002736676.1 1551574 R 488222 CDS YP_002736677.1 225855165 7678826 complement(1552329..1553642) 1 NC_012466.1 identified by match to protein family HMM PF01029; match to protein family HMM PF01189; match to protein family HMM TIGR00563; ribosomal RNA small subunit methyltransferase B 1553642 sun 7678826 sun Streptococcus pneumoniae JJA ribosomal RNA small subunit methyltransferase B YP_002736677.1 1552329 R 488222 CDS YP_002736678.1 225855166 7678606 complement(1553635..1554570) 1 NC_012466.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1554570 fmt 7678606 fmt Streptococcus pneumoniae JJA methionyl-tRNA formyltransferase YP_002736678.1 1553635 R 488222 CDS YP_002736679.1 225855167 7679321 complement(1554583..1556979) 1 NC_012466.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1556979 7679321 SPJ_1632 Streptococcus pneumoniae JJA primosome assembly protein PriA YP_002736679.1 1554583 R 488222 CDS YP_002736680.1 225855168 7679616 complement(1557045..1557356) 1 NC_012466.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1557356 rpoZ 7679616 rpoZ Streptococcus pneumoniae JJA DNA-directed RNA polymerase subunit omega YP_002736680.1 1557045 R 488222 CDS YP_002736681.1 225855169 7680046 complement(1557384..1558010) 1 NC_012466.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1558010 gmk 7680046 gmk Streptococcus pneumoniae JJA guanylate kinase YP_002736681.1 1557384 R 488222 CDS YP_002736682.1 225855170 7678837 complement(1558140..1559753) 1 NC_012466.1 identified by match to protein family HMM PF00013; match to protein family HMM PF01966; match to protein family HMM TIGR00277; match to protein family HMM TIGR03319; hypothetical protein 1559753 7678837 SPJ_1635 Streptococcus pneumoniae JJA hypothetical protein YP_002736682.1 1558140 R 488222 CDS YP_002736683.1 225855171 7679621 complement(1559944..1560198) 1 NC_012466.1 identified by match to protein family HMM PF06769; match to protein family HMM TIGR02116; addiction module toxin, Txe/YoeB family 1560198 7679621 SPJ_1636 Streptococcus pneumoniae JJA addiction module toxin, Txe/YoeB family YP_002736683.1 1559944 R 488222 CDS YP_002736684.1 225855172 7679826 complement(1560202..1560456) 1 NC_012466.1 identified by match to protein family HMM PF02604; match to protein family HMM TIGR01552; prevent-host-death family protein 1560456 7679826 SPJ_1637 Streptococcus pneumoniae JJA prevent-host-death family protein YP_002736684.1 1560202 R 488222 CDS YP_002736685.1 225855173 7678721 complement(1560694..1561791) 1 NC_012466.1 identified by match to protein family HMM PF05636; hypothetical protein 1561791 7678721 SPJ_1638 Streptococcus pneumoniae JJA hypothetical protein YP_002736685.1 1560694 R 488222 CDS YP_002736686.1 225855174 7679339 complement(1561801..1562547) 1 NC_012466.1 identified by match to protein family HMM PF08241; match to protein family HMM PF08242; SAM-dependent methyltransferase 1562547 7679339 SPJ_1639 Streptococcus pneumoniae JJA SAM-dependent methyltransferase YP_002736686.1 1561801 R 488222 CDS YP_002736687.1 225855175 7680000 complement(1562650..1563003) 1 NC_012466.1 identified by match to protein family HMM PF02410; match to protein family HMM TIGR00090; putative iojap homolog 1563003 7680000 SPJ_1640 Streptococcus pneumoniae JJA putative iojap homolog YP_002736687.1 1562650 R 488222 CDS YP_002736688.1 225855176 7679953 complement(1563016..1563516) 1 NC_012466.1 identified by match to protein family HMM PF00857; isochorismatase family protein 1563516 7679953 SPJ_1641 Streptococcus pneumoniae JJA isochorismatase family protein YP_002736688.1 1563016 R 488222 CDS YP_002736689.1 225855177 7680501 complement(1563517..1564110) 1 NC_012466.1 identified by match to protein family HMM PF01966; match to protein family HMM TIGR00488; hypothetical protein 1564110 7680501 SPJ_1642 Streptococcus pneumoniae JJA hypothetical protein YP_002736689.1 1563517 R 488222 CDS YP_002736690.1 225855178 7678396 complement(1564110..1564739) 1 NC_012466.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 1564739 nadD 7678396 nadD Streptococcus pneumoniae JJA nicotinic acid mononucleotide adenylyltransferase YP_002736690.1 1564110 R 488222 CDS YP_002736691.1 225855179 7679133 complement(1564791..1565102) 1 NC_012466.1 identified by match to protein family HMM PF01985; match to protein family HMM TIGR00253; hypothetical protein 1565102 7679133 SPJ_1644 Streptococcus pneumoniae JJA hypothetical protein YP_002736691.1 1564791 R 488222 CDS YP_002736692.1 225855180 7678751 complement(1565317..1566423) 1 NC_012466.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH 1566423 7678751 SPJ_1645 Streptococcus pneumoniae JJA GTP-binding protein YqeH YP_002736692.1 1565317 R 488222 CDS YP_002736693.1 225855181 7679255 complement(1566426..1566953) 1 NC_012466.1 identified by match to protein family HMM TIGR01662; match to protein family HMM TIGR01668; had superfamily (subfamily iiia) phosphatase 1566953 yqeG 7679255 yqeG Streptococcus pneumoniae JJA had superfamily (subfamily iiia) phosphatase YP_002736693.1 1566426 R 488222 CDS YP_002736694.1 225855182 7680034 complement(1566968..1567876) 1 NC_012466.1 identified by match to protein family HMM PF01544; CorA - magnesium and cobalt transporter 1567876 7680034 SPJ_1647 Streptococcus pneumoniae JJA CorA - magnesium and cobalt transporter YP_002736694.1 1566968 R 488222 CDS YP_002736695.1 225855183 7679932 complement(1567933..1568493) 1 NC_012466.1 identified by match to protein family HMM PF00924; small conductance mechanosensitive ion channel 1568493 7679932 SPJ_1648 Streptococcus pneumoniae JJA small conductance mechanosensitive ion channel YP_002736695.1 1567933 R 488222 CDS YP_002736696.1 225855184 7678756 1569907..1570860 1 NC_012466.1 identified by match to protein family HMM PF06081; integral membrane protein 1570860 7678756 SPJ_1651 Streptococcus pneumoniae JJA integral membrane protein YP_002736696.1 1569907 D 488222 CDS YP_002736697.1 225855185 7679197 complement(1571096..1571320) 1 NC_012466.1 hypothetical protein 1571320 7679197 SPJ_1652 Streptococcus pneumoniae JJA hypothetical protein YP_002736697.1 1571096 R 488222 CDS YP_002736698.1 225855186 7678562 complement(1571325..1571504) 1 NC_012466.1 hypothetical protein 1571504 7678562 SPJ_1653 Streptococcus pneumoniae JJA hypothetical protein YP_002736698.1 1571325 R 488222 CDS YP_002736699.1 225855187 7680149 complement(1571506..1572843) 1 NC_012466.1 identified by match to protein family HMM TIGR02919; hypothetical protein 1572843 7680149 SPJ_1654 Streptococcus pneumoniae JJA hypothetical protein YP_002736699.1 1571506 R 488222 CDS YP_002736700.1 225855188 7678957 complement(1572836..1574347) 1 NC_012466.1 identified by match to protein family HMM PF00534; match to protein family HMM PF09318; match to protein family HMM TIGR02918; hypothetical protein 1574347 7678957 SPJ_1655 Streptococcus pneumoniae JJA hypothetical protein YP_002736700.1 1572836 R 488222 CDS YP_002736701.1 225855189 7678453 complement(1574359..1576731) 1 NC_012466.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins; preprotein translocase subunit SecA 1576731 7678453 SPJ_1656 Streptococcus pneumoniae JJA preprotein translocase subunit SecA YP_002736701.1 1574359 R 488222 CDS YP_002736702.1 225855190 7678813 complement(1576724..1577164) 1 NC_012466.1 accessory secretory protein Asp3 1577164 7678813 SPJ_1657 Streptococcus pneumoniae JJA accessory secretory protein Asp3 YP_002736702.1 1576724 R 488222 CDS YP_002736703.1 225855191 7680512 complement(1577161..1578696) 1 NC_012466.1 accessory secretory protein Asp2 1578696 7680512 SPJ_1658 Streptococcus pneumoniae JJA accessory secretory protein Asp2 YP_002736703.1 1577161 R 488222 CDS YP_002736704.1 225855192 7679632 complement(1578680..1580260) 1 NC_012466.1 accessory secretory protein Asp1 1580260 7679632 SPJ_1659 Streptococcus pneumoniae JJA accessory secretory protein Asp1 YP_002736704.1 1578680 R 488222 CDS YP_002736705.1 225855193 7679301 complement(1580270..1581487) 1 NC_012466.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 1581487 secY 7679301 secY Streptococcus pneumoniae JJA preprotein translocase subunit SecY YP_002736705.1 1580270 R 488222 CDS YP_002736706.1 225855194 7680078 complement(1581544..1582449) 1 NC_012466.1 identified by match to protein family HMM PF00535; glycosyl transferase, family 2 1582449 7680078 SPJ_1661 Streptococcus pneumoniae JJA glycosyl transferase, family 2 YP_002736706.1 1581544 R 488222 CDS YP_002736707.1 225855195 7679652 complement(1582449..1583645) 1 NC_012466.1 identified by match to protein family HMM PF01501; glycosyl transferase, family 8 1583645 7679652 SPJ_1662 Streptococcus pneumoniae JJA glycosyl transferase, family 8 YP_002736707.1 1582449 R 488222 CDS YP_002736708.1 225855196 7679930 complement(1583654..1584874) 1 NC_012466.1 identified by match to protein family HMM PF01501; glycosyl transferase, family 8 1584874 7679930 SPJ_1663 Streptococcus pneumoniae JJA glycosyl transferase, family 8 YP_002736708.1 1583654 R 488222 CDS YP_002736709.1 225855197 7678417 complement(1584905..1587349) 1 NC_012466.1 identified by match to protein family HMM PF01501; match to protein family HMM PF08759; glycosyl transferase, family 8 1587349 7678417 SPJ_1664 Streptococcus pneumoniae JJA glycosyl transferase, family 8 YP_002736709.1 1584905 R 488222 CDS YP_002736710.1 225855198 7680542 complement(1587359..1588369) 1 NC_012466.1 hypothetical protein 1588369 7680542 SPJ_1665 Streptococcus pneumoniae JJA hypothetical protein YP_002736710.1 1587359 R 488222 CDS YP_002736711.1 225855199 7679949 complement(1588398..1589273) 1 NC_012466.1 identified by match to protein family HMM PF00535; glycosyl transferase, family 2/glycosyl transferase family 8 1589273 7679949 SPJ_1666 Streptococcus pneumoniae JJA glycosyl transferase, family 2/glycosyl transferase family 8 YP_002736711.1 1588398 R 488222 CDS YP_002736712.1 225855200 7679349 complement(1589278..1590492) 1 NC_012466.1 identified by match to protein family HMM PF01501; glycosyl transferase, family 8 1590492 7679349 SPJ_1667 Streptococcus pneumoniae JJA glycosyl transferase, family 8 YP_002736712.1 1589278 R 488222 CDS YP_002736713.1 225855201 7679924 complement(1590799..1592883) 1 NC_012466.1 identified by match to protein family HMM PF00535; match to protein family HMM PF01501; glycosyl transferase, family 2/glycosyl transferase family 8 1592883 7679924 SPJ_1668 Streptococcus pneumoniae JJA glycosyl transferase, family 2/glycosyl transferase family 8 YP_002736713.1 1590799 R 488222 CDS YP_002736714.1 225855202 7678683 complement(1601569..1602030) 1 NC_012466.1 hypothetical protein 1602030 7678683 SPJ_1670 Streptococcus pneumoniae JJA hypothetical protein YP_002736714.1 1601569 R 488222 CDS YP_002736715.1 225855203 7679911 1602409..1602789 1 NC_012466.1 identified by match to protein family HMM PF01047; transcriptional regulator, putative 1602789 7679911 SPJ_1671 Streptococcus pneumoniae JJA transcriptional regulator, putative YP_002736715.1 1602409 D 488222 CDS YP_002736716.1 225855204 7679451 1602888..1603109 1 NC_012466.1 hypothetical protein 1603109 7679451 SPJ_1672 Streptococcus pneumoniae JJA hypothetical protein YP_002736716.1 1602888 D 488222 CDS YP_002736717.1 225855205 7678668 1603126..1603440 1 NC_012466.1 identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin 1603440 trx 7678668 trx Streptococcus pneumoniae JJA thioredoxin YP_002736717.1 1603126 D 488222 CDS YP_002736718.1 225855206 7680421 1603746..1604279 1 NC_012466.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 1604279 7680421 SPJ_1674 Streptococcus pneumoniae JJA 7-cyano-7-deazaguanine reductase YP_002736718.1 1603746 D 488222 CDS YP_002736719.1 225855207 7679799 1604291..1604668 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1604668 7679799 SPJ_1675 Streptococcus pneumoniae JJA hypothetical protein YP_002736719.1 1604291 D 488222 CDS YP_002736720.1 225855208 7680202 complement(1604758..1605426) 1 NC_012466.1 identified by match to protein family HMM PF00230; aquaporin Z - water channel protein 1605426 7680202 SPJ_1676 Streptococcus pneumoniae JJA aquaporin Z - water channel protein YP_002736720.1 1604758 R 488222 CDS YP_002736721.1 225855209 7678769 complement(1605537..1606091) 1 NC_012466.1 hypothetical protein 1606091 7678769 SPJ_1677 Streptococcus pneumoniae JJA hypothetical protein YP_002736721.1 1605537 R 488222 CDS YP_002736722.1 225855210 7679447 complement(1606159..1606314) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1606314 7679447 SPJ_1678 Streptococcus pneumoniae JJA hypothetical protein YP_002736722.1 1606159 R 488222 CDS YP_002736723.1 225855211 7679962 complement(1606337..1608133) 1 NC_012466.1 identified by match to protein family HMM PF01432; match to protein family HMM PF08439; match to protein family HMM TIGR00181; oligoendopeptidase F 1608133 pepF2 7679962 pepF2 Streptococcus pneumoniae JJA oligoendopeptidase F YP_002736723.1 1606337 R 488222 CDS YP_002736724.1 225855212 7679619 complement(1608144..1608887) 1 NC_012466.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 1608887 7679619 SPJ_1680 Streptococcus pneumoniae JJA 16S ribosomal RNA methyltransferase RsmE YP_002736724.1 1608144 R 488222 CDS YP_002736725.1 225855213 7680097 complement(1608889..1609839) 1 NC_012466.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 1609839 prmA 7680097 prmA Streptococcus pneumoniae JJA ribosomal protein L11 methyltransferase YP_002736725.1 1608889 R 488222 CDS YP_002736726.1 225855214 7678629 complement(1609852..1610871) 1 NC_012466.1 putative otitis media-associated P41 1610871 7678629 SPJ_1682 Streptococcus pneumoniae JJA putative otitis media-associated P41 YP_002736726.1 1609852 R 488222 CDS YP_002736727.1 225855215 7679328 complement(1610922..1613105) 1 NC_012466.1 hypothetical protein 1613105 7679328 SPJ_1683 Streptococcus pneumoniae JJA hypothetical protein YP_002736727.1 1610922 R 488222 CDS YP_002736728.1 225855216 7679155 complement(1613167..1614201) 1 NC_012466.1 identified by match to protein family HMM PF00004; ATPase of the AAA+ class 1614201 7679155 SPJ_1684 Streptococcus pneumoniae JJA ATPase of the AAA+ class YP_002736728.1 1613167 R 488222 CDS YP_002736729.1 225855217 7679482 complement(1614311..1614469) 1 NC_012466.1 7,8-dihydro-8-oxoguanine-triphosphatase 1614469 7679482 SPJ_1685 Streptococcus pneumoniae JJA 7,8-dihydro-8-oxoguanine-triphosphatase YP_002736729.1 1614311 R 488222 CDS YP_002736730.1 225855218 7678682 complement(1614450..1615538) 1 NC_012466.1 identified by match to protein family HMM PF02163; peptidase, M50 family protein 1615538 7678682 SPJ_1686 Streptococcus pneumoniae JJA peptidase, M50 family protein YP_002736730.1 1614450 R 488222 CDS YP_002736731.1 225855219 7679672 complement(1615557..1616027) 1 NC_012466.1 hypothetical protein 1616027 7679672 SPJ_1687 Streptococcus pneumoniae JJA hypothetical protein YP_002736731.1 1615557 R 488222 CDS YP_002736732.1 225855220 7680255 complement(1616318..1616770) 1 NC_012466.1 identified by match to protein family HMM PF03681; hypothetical protein 1616770 7680255 SPJ_1688 Streptococcus pneumoniae JJA hypothetical protein YP_002736732.1 1616318 R 488222 CDS YP_002736733.1 225855221 7678451 complement(1616807..1616986) 1 NC_012466.1 identified by match to protein family HMM PF07927; hypothetical protein 1616986 7678451 SPJ_1689 Streptococcus pneumoniae JJA hypothetical protein YP_002736733.1 1616807 R 488222 CDS YP_002736734.1 225855222 7679010 complement(1617123..1617302) 1 NC_012466.1 hypothetical protein 1617302 7679010 SPJ_1690 Streptococcus pneumoniae JJA hypothetical protein YP_002736734.1 1617123 R 488222 CDS YP_002736735.1 225855223 7679926 1617976..1619247 1 NC_012466.1 identified by match to protein family HMM PF00004; recombination factor protein RarA 1619247 7679926 SPJ_1691 Streptococcus pneumoniae JJA recombination factor protein RarA YP_002736735.1 1617976 D 488222 CDS YP_002736736.1 225855224 7680593 complement(1619794..1621113) 1 NC_012466.1 identified by match to protein family HMM PF00251; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase 1621113 7680593 SPJ_1693 Streptococcus pneumoniae JJA sucrose-6-phosphate hydrolase YP_002736736.1 1619794 R 488222 CDS YP_002736737.1 225855225 7678879 complement(1621123..1622739) 1 NC_012466.1 identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein 1622739 7678879 SPJ_1694 Streptococcus pneumoniae JJA ABC transporter substrate-binding protein YP_002736737.1 1621123 R 488222 CDS YP_002736738.1 225855226 7679638 complement(1622768..1623658) 1 NC_012466.1 identified by match to protein family HMM PF00528; protein LplC 1623658 7679638 SPJ_1695 Streptococcus pneumoniae JJA protein LplC YP_002736738.1 1622768 R 488222 CDS YP_002736739.1 225855227 7679831 complement(1623669..1624586) 1 NC_012466.1 identified by match to protein family HMM PF00528; protein LplB 1624586 7679831 SPJ_1696 Streptococcus pneumoniae JJA protein LplB YP_002736739.1 1623669 R 488222 CDS YP_002736740.1 225855228 7679363 complement(1624735..1625736) 1 NC_012466.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sugar-binding transcriptional regulator, LacI family 1625736 7679363 SPJ_1697 Streptococcus pneumoniae JJA sugar-binding transcriptional regulator, LacI family YP_002736740.1 1624735 R 488222 CDS YP_002736741.1 225855229 7679855 complement(1626098..1627579) 1 NC_012466.1 identified by match to protein family HMM PF05043; match to protein family HMM PF08270; match to protein family HMM PF08279; match to protein family HMM PF08280; M protein trans-acting positive transcriptional regulator 1627579 7679855 SPJ_1698 Streptococcus pneumoniae JJA M protein trans-acting positive transcriptional regulator YP_002736741.1 1626098 R 488222 CDS YP_002736742.1 225855230 7678410 1628022..1628186 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1628186 7678410 SPJ_1699 Streptococcus pneumoniae JJA hypothetical protein YP_002736742.1 1628022 D 488222 CDS YP_002736743.1 225855231 7678877 1628270..1628836 1 NC_012466.1 hypothetical protein 1628836 7678877 SPJ_1700 Streptococcus pneumoniae JJA hypothetical protein YP_002736743.1 1628270 D 488222 CDS YP_002736744.1 225855232 7679755 1628848..1629018 1 NC_012466.1 lipoprotein, putative 1629018 7679755 SPJ_1701 Streptococcus pneumoniae JJA lipoprotein, putative YP_002736744.1 1628848 D 488222 CDS YP_002736745.1 225855233 7680233 1629057..1629665 1 NC_012466.1 identified by match to protein family HMM PF03780; Gls24 protein 1629665 7680233 SPJ_1702 Streptococcus pneumoniae JJA Gls24 protein YP_002736745.1 1629057 D 488222 CDS YP_002736746.1 225855234 7678768 1629696..1629899 1 NC_012466.1 identified by match to protein family HMM PF05532; hypothetical protein 1629899 7678768 SPJ_1703 Streptococcus pneumoniae JJA hypothetical protein YP_002736746.1 1629696 D 488222 CDS YP_002736747.1 225855235 7679375 1630485..1630682 1 NC_012466.1 transposase 1630682 7679375 SPJ_1704 Streptococcus pneumoniae JJA transposase YP_002736747.1 1630485 D 488222 CDS YP_002736748.1 225855236 7679701 complement(1630713..1630832) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1630832 7679701 SPJ_1705 Streptococcus pneumoniae JJA hypothetical protein YP_002736748.1 1630713 R 488222 CDS YP_002736749.1 225855237 7680317 complement(1631051..1631821) 1 NC_012466.1 identified by match to protein family HMM PF01925; hypothetical protein 1631821 7680317 SPJ_1706 Streptococcus pneumoniae JJA hypothetical protein YP_002736749.1 1631051 R 488222 CDS YP_002736750.1 225855238 7679590 complement(1631836..1632684) 1 NC_012466.1 identified by match to protein family HMM PF03781; sulfatase-modifying factor 1 (C-alpha-formyglycine-generating enzyme 1) 1632684 7679590 SPJ_1707 Streptococcus pneumoniae JJA sulfatase-modifying factor 1 (C-alpha-formyglycine-generating enzyme 1) YP_002736750.1 1631836 R 488222 CDS YP_002736751.1 225855239 7680210 complement(1632681..1634156) 1 NC_012466.1 can hydrolyze p-nitrophenyl sulfate; contains a specific cysteine that is converted into C{alpha]-formylglycine upon activation with the anaerobic sulfatase-maturase; arylsulfatase 1634156 7680210 SPJ_1708 Streptococcus pneumoniae JJA arylsulfatase YP_002736751.1 1632681 R 488222 CDS YP_002736752.1 225855240 7680095 complement(1634479..1635834) 1 NC_012466.1 identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; phosphotransferase system 1635834 7680095 SPJ_1709 Streptococcus pneumoniae JJA phosphotransferase system YP_002736752.1 1634479 R 488222 CDS YP_002736753.1 225855241 7678502 complement(1635844..1636161) 1 NC_012466.1 identified by match to protein family HMM PF02255; lichenan-specific phosphotransferase enzyme iia component (pts system lichenan-specific eiia component) (eiia-lic) (eiii-lic) 1636161 7678502 SPJ_1710 Streptococcus pneumoniae JJA lichenan-specific phosphotransferase enzyme iia component (pts system lichenan-specific eiia component) (eiia-lic) (eiii-lic) YP_002736753.1 1635844 R 488222 CDS YP_002736754.1 225855242 7679399 complement(1636178..1636495) 1 NC_012466.1 identified by match to protein family HMM PF02302; lichenan-specific phosphotransferase enzyme iib component (pts system lichenan-specific eiib component) (eiib-lic) 1636495 7679399 SPJ_1711 Streptococcus pneumoniae JJA lichenan-specific phosphotransferase enzyme iib component (pts system lichenan-specific eiib component) (eiib-lic) YP_002736754.1 1636178 R 488222 CDS YP_002736755.1 225855243 7679880 complement(1636510..1637406) 1 NC_012466.1 hypothetical protein 1637406 7679880 SPJ_1712 Streptococcus pneumoniae JJA hypothetical protein YP_002736755.1 1636510 R 488222 CDS YP_002736756.1 225855244 7679791 complement(1637409..1638671) 1 NC_012466.1 identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) 1638671 7679791 SPJ_1713 Streptococcus pneumoniae JJA lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) YP_002736756.1 1637409 R 488222 CDS YP_002736757.1 225855245 7678634 1638951..1640129 1 NC_012466.1 identified by match to protein family HMM PF00480; ROK family protein, putative 1640129 7678634 SPJ_1714 Streptococcus pneumoniae JJA ROK family protein, putative YP_002736757.1 1638951 D 488222 CDS YP_002736758.1 225855246 7679090 complement(1640357..1640803) 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 1640803 7679090 SPJ_1715 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002736758.1 1640357 R 488222 CDS YP_002736759.1 225855247 7679568 1640873..1641532 1 NC_012466.1 identified by match to protein family HMM PF01478; match to protein family HMM PF06750; type 4 prepilin peptidase 1641532 7679568 SPJ_1716 Streptococcus pneumoniae JJA type 4 prepilin peptidase YP_002736759.1 1640873 D 488222 CDS YP_002736760.1 225855248 7680045 complement(1641584..1642735) 1 NC_012466.1 identified by match to protein family HMM PF01381; match to protein family HMM PF06114; transcriptional regulator 1642735 7680045 SPJ_1717 Streptococcus pneumoniae JJA transcriptional regulator YP_002736760.1 1641584 R 488222 CDS YP_002736761.1 225855249 7680479 complement(1642750..1643481) 1 NC_012466.1 hypothetical protein 1643481 7680479 SPJ_1718 Streptococcus pneumoniae JJA hypothetical protein YP_002736761.1 1642750 R 488222 CDS YP_002736762.1 225855250 7678416 complement(1643783..1644559) 1 NC_012466.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1644559 trpA 7678416 trpA Streptococcus pneumoniae JJA tryptophan synthase subunit alpha YP_002736762.1 1643783 R 488222 CDS YP_002736763.1 225855251 7680278 complement(1644552..1645775) 1 NC_012466.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1645775 trpB 7680278 trpB Streptococcus pneumoniae JJA tryptophan synthase subunit beta YP_002736763.1 1644552 R 488222 CDS YP_002736764.1 225855252 7679679 complement(1645753..1646352) 1 NC_012466.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase 1646352 trpF 7679679 trpF Streptococcus pneumoniae JJA N-(5'-phosphoribosyl)anthranilate isomerase YP_002736764.1 1645753 R 488222 CDS YP_002736765.1 225855253 7679310 complement(1646339..1647106) 1 NC_012466.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 1647106 trpC 7679310 trpC Streptococcus pneumoniae JJA indole-3-glycerol-phosphate synthase YP_002736765.1 1646339 R 488222 CDS YP_002736766.1 225855254 7678890 complement(1647103..1648107) 1 NC_012466.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1648107 trpD 7678890 trpD Streptococcus pneumoniae JJA anthranilate phosphoribosyltransferase YP_002736766.1 1647103 R 488222 CDS YP_002736767.1 225855255 7680481 complement(1648118..1648684) 1 NC_012466.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1648684 7680481 SPJ_1724 Streptococcus pneumoniae JJA anthranilate synthase component II YP_002736767.1 1648118 R 488222 CDS YP_002736768.1 225855256 7679003 complement(1648681..1650042) 1 NC_012466.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1650042 trpE 7679003 trpE Streptococcus pneumoniae JJA anthranilate synthase component I YP_002736768.1 1648681 R 488222 CDS YP_002736769.1 225855257 7678435 complement(1650451..1650711) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1650711 7678435 SPJ_1726 Streptococcus pneumoniae JJA hypothetical protein YP_002736769.1 1650451 R 488222 CDS YP_002736770.1 225855258 7679074 complement(1651319..1652320) 1 NC_012466.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; catabolite control protein 1652320 7679074 SPJ_1727 Streptococcus pneumoniae JJA catabolite control protein YP_002736770.1 1651319 R 488222 CDS YP_002736771.1 225855259 7678616 complement(1652428..1652796) 1 NC_012466.1 hypothetical protein 1652796 7678616 SPJ_1728 Streptococcus pneumoniae JJA hypothetical protein YP_002736771.1 1652428 R 488222 CDS YP_002736772.1 225855260 7680182 complement(1652892..1653602) 1 NC_012466.1 identified by match to protein family HMM PF02308; putative Mg2+ transporter-C (MgtC) family protein 1653602 7680182 SPJ_1729 Streptococcus pneumoniae JJA putative Mg2+ transporter-C (MgtC) family protein YP_002736772.1 1652892 R 488222 CDS YP_002736773.1 225855261 7679636 complement(1653605..1655296) 1 NC_012466.1 identified by match to protein family HMM PF00528; binding-protein-dependent transport systems inner membrane component 1655296 7679636 SPJ_1730 Streptococcus pneumoniae JJA binding-protein-dependent transport systems inner membrane component YP_002736773.1 1653605 R 488222 CDS YP_002736774.1 225855262 7679005 complement(1655308..1656318) 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; spermidine/putrescine import ATP-binding protein PotA 1656318 7679005 SPJ_1731 Streptococcus pneumoniae JJA spermidine/putrescine import ATP-binding protein PotA YP_002736774.1 1655308 R 488222 CDS YP_002736775.1 225855263 7678928 complement(1656421..1657488) 1 NC_012466.1 ABC transporter substrate-binding protein 1657488 7678928 SPJ_1732 Streptococcus pneumoniae JJA ABC transporter substrate-binding protein YP_002736775.1 1656421 R 488222 CDS YP_002736776.1 225855264 7680130 complement(1657513..1658172) 1 NC_012466.1 identified by match to protein family HMM PF08975; hypothetical protein 1658172 7680130 SPJ_1733 Streptococcus pneumoniae JJA hypothetical protein YP_002736776.1 1657513 R 488222 CDS YP_002736777.1 225855265 7679863 complement(1658300..1658413) 1 NC_012466.1 hypothetical protein 1658413 7679863 SPJ_1734 Streptococcus pneumoniae JJA hypothetical protein YP_002736777.1 1658300 R 488222 CDS YP_002736778.1 225855266 7679225 complement(1658382..1659362) 1 NC_012466.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase 1659362 galE2 7679225 galE2 Streptococcus pneumoniae JJA UDP-glucose 4-epimerase YP_002736778.1 1658382 R 488222 CDS YP_002736779.1 225855267 7679139 complement(1659375..1660850) 1 NC_012466.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase 1660850 galT1 7679139 galT1 Streptococcus pneumoniae JJA galactose-1-phosphate uridylyltransferase YP_002736779.1 1659375 R 488222 CDS YP_002736780.1 225855268 7679309 complement(1660863..1661504) 1 NC_012466.1 identified by match to protein family HMM PF01895; PhoU family 1661504 7679309 SPJ_1737 Streptococcus pneumoniae JJA PhoU family YP_002736780.1 1660863 R 488222 CDS YP_002736781.1 225855269 7678670 complement(1661562..1661963) 1 NC_012466.1 hypothetical protein 1661963 7678670 SPJ_1738 Streptococcus pneumoniae JJA hypothetical protein YP_002736781.1 1661562 R 488222 CDS YP_002736782.1 225855270 7680086 complement(1662117..1662413) 1 NC_012466.1 hypothetical protein 1662413 7680086 SPJ_1739 Streptococcus pneumoniae JJA hypothetical protein YP_002736782.1 1662117 R 488222 CDS YP_002736783.1 225855271 7679660 complement(1662397..1664523) 1 NC_012466.1 identified by match to protein family HMM PF04650; match to protein family HMM TIGR01168; cell wall surface anchor family protein 1664523 7679660 SPJ_1740 Streptococcus pneumoniae JJA cell wall surface anchor family protein YP_002736783.1 1662397 R 488222 CDS YP_002736784.1 225855272 7679402 1665469..1665645 1 NC_012466.1 hypothetical protein 1665645 7679402 SPJ_1741 Streptococcus pneumoniae JJA hypothetical protein YP_002736784.1 1665469 D 488222 CDS YP_002736785.1 225855273 7678907 complement(1665687..1666913) 1 NC_012466.1 identified by match to protein family HMM PF01041; Cps7G 1666913 7678907 SPJ_1742 Streptococcus pneumoniae JJA Cps7G YP_002736785.1 1665687 R 488222 CDS YP_002736786.1 225855274 7678576 complement(1666956..1667648) 1 NC_012466.1 identified by match to protein family HMM PF02397; sugar transferase family protein 1667648 7678576 SPJ_1743 Streptococcus pneumoniae JJA sugar transferase family protein YP_002736786.1 1666956 R 488222 CDS YP_002736787.1 225855275 7680168 complement(1667821..1669572) 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein 1669572 7680168 SPJ_1744 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002736787.1 1667821 R 488222 CDS YP_002736788.1 225855276 7679881 complement(1669562..1671307) 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein 1671307 7679881 SPJ_1745 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002736788.1 1669562 R 488222 CDS YP_002736789.1 225855277 7679092 complement(1671513..1671890) 1 NC_012466.1 identified by match to protein family HMM PF04239; hypothetical protein 1671890 7679092 SPJ_1746 Streptococcus pneumoniae JJA hypothetical protein YP_002736789.1 1671513 R 488222 CDS YP_002736790.1 225855278 7679689 complement(1671962..1672237) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1672237 7679689 SPJ_1747 Streptococcus pneumoniae JJA hypothetical protein YP_002736790.1 1671962 R 488222 CDS YP_002736791.1 225855279 7679897 complement(1672191..1672418) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1672418 7679897 SPJ_1748 Streptococcus pneumoniae JJA hypothetical protein YP_002736791.1 1672191 R 488222 CDS YP_002736792.1 225855280 7679777 1672552..1673379 1 NC_012466.1 identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633; exodeoxyribonuclease III 1673379 xth 7679777 xth Streptococcus pneumoniae JJA exodeoxyribonuclease III YP_002736792.1 1672552 D 488222 CDS YP_002736793.1 225855281 7678817 1674651..1675232 1 NC_012466.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 1675232 xpt 7678817 xpt Streptococcus pneumoniae JJA xanthine phosphoribosyltransferase YP_002736793.1 1674651 D 488222 CDS YP_002736794.1 225855282 7679453 1675232..1676494 1 NC_012466.1 identified by match to protein family HMM PF00860; match to protein family HMM PF00916; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173; xanthine permease 1676494 7679453 SPJ_1753 Streptococcus pneumoniae JJA xanthine permease YP_002736794.1 1675232 D 488222 CDS YP_002736795.1 225855283 7679520 complement(1676545..1677006) 1 NC_012466.1 protein DpnD 1677006 7679520 SPJ_1754 Streptococcus pneumoniae JJA protein DpnD YP_002736795.1 1676545 R 488222 CDS YP_002736796.1 225855284 7680208 complement(1677003..1677767) 1 NC_012466.1 identified by match to protein family HMM PF06044; type II restriction enzyme 1677767 7680208 SPJ_1755 Streptococcus pneumoniae JJA type II restriction enzyme YP_002736796.1 1677003 R 488222 CDS YP_002736797.1 225855285 7678482 complement(1677948..1678352) 1 NC_012466.1 identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; thioesterase family protein 1678352 7678482 SPJ_1756 Streptococcus pneumoniae JJA thioesterase family protein YP_002736797.1 1677948 R 488222 CDS YP_002736798.1 225855286 7679807 complement(1678422..1679903) 1 NC_012466.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase 1679903 galT2 7679807 galT2 Streptococcus pneumoniae JJA galactose-1-phosphate uridylyltransferase YP_002736798.1 1678422 R 488222 CDS YP_002736799.1 225855287 7679467 complement(1679922..1681100) 1 NC_012466.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 1681100 galK 7679467 galK Streptococcus pneumoniae JJA galactokinase YP_002736799.1 1679922 R 488222 CDS YP_002736800.1 225855288 7678763 1681265..1682272 1 NC_012466.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; GalR, member of GalR-LacI family of transcriptional regulators, binds DNA; regulator of gal operon 1682272 7678763 SPJ_1759 Streptococcus pneumoniae JJA GalR, member of GalR-LacI family of transcriptional regulators, binds DNA; regulator of gal operon YP_002736800.1 1681265 D 488222 CDS YP_002736801.1 225855289 7680212 complement(1682318..1683355) 1 NC_012466.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; alcohol dehydrogenase, zinc-containing 1683355 7680212 SPJ_1760 Streptococcus pneumoniae JJA alcohol dehydrogenase, zinc-containing YP_002736801.1 1682318 R 488222 CDS YP_002736802.1 225855290 7679117 complement(1683356..1683709) 1 NC_012466.1 identified by match to protein family HMM PF00376; transcriptional regulator, MerR family 1683709 7679117 SPJ_1761 Streptococcus pneumoniae JJA transcriptional regulator, MerR family YP_002736802.1 1683356 R 488222 CDS YP_002736803.1 225855291 7680415 complement(1683953..1684843) 1 NC_012466.1 identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation diffusion facilitator transporter - heavy metal transport 1684843 7680415 SPJ_1762 Streptococcus pneumoniae JJA cation diffusion facilitator transporter - heavy metal transport YP_002736803.1 1683953 R 488222 CDS YP_002736804.1 225855292 7680438 1684976..1685512 1 NC_012466.1 identified by match to protein family HMM PF00440; TetR family transcriptional regulator 1685512 7680438 SPJ_1763 Streptococcus pneumoniae JJA TetR family transcriptional regulator YP_002736804.1 1684976 D 488222 CDS YP_002736805.1 225855293 7679996 complement(1685678..1686484) 1 NC_012466.1 identified by match to protein family HMM PF04973; match to protein family HMM TIGR01528; nicotinamide mononucleotide transporter 1686484 7679996 SPJ_1764 Streptococcus pneumoniae JJA nicotinamide mononucleotide transporter YP_002736805.1 1685678 R 488222 CDS YP_002736806.1 225855294 7678861 complement(1686655..1686771) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1686771 7678861 SPJ_1765 Streptococcus pneumoniae JJA hypothetical protein YP_002736806.1 1686655 R 488222 CDS YP_002736807.1 225855295 7680311 complement(1686829..1688349) 1 NC_012466.1 identified by match to protein family HMM PF00528; match to protein family HMM PF04069; choline ABC transporter permease 1688349 7680311 SPJ_1766 Streptococcus pneumoniae JJA choline ABC transporter permease YP_002736807.1 1686829 R 488222 CDS YP_002736808.1 225855296 7679359 complement(1688342..1689070) 1 NC_012466.1 identified by match to protein family HMM PF00005; choline transport ATP-binding protein opuBA 1689070 7679359 SPJ_1767 Streptococcus pneumoniae JJA choline transport ATP-binding protein opuBA YP_002736808.1 1688342 R 488222 CDS YP_002736809.1 225855297 7678922 complement(1689085..1689849) 1 NC_012466.1 identified by match to protein family HMM PF07366; hypothetical protein 1689849 7678922 SPJ_1768 Streptococcus pneumoniae JJA hypothetical protein YP_002736809.1 1689085 R 488222 CDS YP_002736810.1 225855298 7679754 complement(1689853..1690296) 1 NC_012466.1 identified by match to protein family HMM PF01047; transcriptional regulator, MarR family 1690296 7679754 SPJ_1769 Streptococcus pneumoniae JJA transcriptional regulator, MarR family YP_002736810.1 1689853 R 488222 CDS YP_002736811.1 225855299 7678975 complement(1690978..1691274) 1 NC_012466.1 identified by match to protein family HMM PF08957; hypothetical protein 1691274 7678975 SPJ_1770 Streptococcus pneumoniae JJA hypothetical protein YP_002736811.1 1690978 R 488222 CDS YP_002736812.1 225855300 7680302 complement(1691296..1692360) 1 NC_012466.1 identified by match to protein family HMM PF05343; match to protein family HMM TIGR03107; glutamyl aminopeptidase 1692360 pepA 7680302 pepA Streptococcus pneumoniae JJA glutamyl aminopeptidase YP_002736812.1 1691296 R 488222 CDS YP_002736813.1 225855301 7679830 1692480..1692602 1 NC_012466.1 hypothetical protein 1692602 7679830 SPJ_1772 Streptococcus pneumoniae JJA hypothetical protein YP_002736813.1 1692480 D 488222 CDS YP_002736814.1 225855302 7679472 1693885..1694844 1 NC_012466.1 identified by match to protein family HMM PF01032; Fe3+ ABC transporter permease 1694844 7679472 SPJ_1774 Streptococcus pneumoniae JJA Fe3+ ABC transporter permease YP_002736814.1 1693885 D 488222 CDS YP_002736815.1 225855303 7678854 1694834..1695790 1 NC_012466.1 identified by match to protein family HMM PF01032; Fe3+ ABC transporter permease 1695790 7678854 SPJ_1775 Streptococcus pneumoniae JJA Fe3+ ABC transporter permease YP_002736815.1 1694834 D 488222 CDS YP_002736816.1 225855304 7680052 1695787..1696539 1 NC_012466.1 identified by match to protein family HMM PF00005; ferrichrome transport ATP-binding protein FhuC 1696539 7680052 SPJ_1776 Streptococcus pneumoniae JJA ferrichrome transport ATP-binding protein FhuC YP_002736816.1 1695787 D 488222 CDS YP_002736817.1 225855305 7678525 1696635..1697600 1 NC_012466.1 identified by match to protein family HMM PF01497; iron-compound ABC transporter, iron-compound-binding protein 1697600 7678525 SPJ_1777 Streptococcus pneumoniae JJA iron-compound ABC transporter, iron-compound-binding protein YP_002736817.1 1696635 D 488222 CDS YP_002736818.1 225855306 7680240 complement(1697825..1698067) 1 NC_012466.1 identified by match to protein family HMM PF01809; match to protein family HMM TIGR00278; hypothetical protein 1698067 7680240 SPJ_1778 Streptococcus pneumoniae JJA hypothetical protein YP_002736818.1 1697825 R 488222 CDS YP_002736819.1 225855307 7680354 complement(1698067..1698789) 1 NC_012466.1 identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal large subunit pseudouridine synthase B 1698789 rluB 7680354 rluB Streptococcus pneumoniae JJA ribosomal large subunit pseudouridine synthase B YP_002736819.1 1698067 R 488222 CDS YP_002736820.1 225855308 7679899 complement(1698776..1699345) 1 NC_012466.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B 1699345 scpB 7679899 scpB Streptococcus pneumoniae JJA segregation and condensation protein B YP_002736820.1 1698776 R 488222 CDS YP_002736821.1 225855309 7680326 complement(1699364..1700092) 1 NC_012466.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A 1700092 scpA 7680326 scpA Streptococcus pneumoniae JJA segregation and condensation protein A YP_002736821.1 1699364 R 488222 CDS YP_002736822.1 225855310 7679858 complement(1700092..1700832) 1 NC_012466.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD-like protein 1700832 xerD 7679858 xerD Streptococcus pneumoniae JJA site-specific tyrosine recombinase XerD-like protein YP_002736822.1 1700092 R 488222 CDS YP_002736823.1 225855311 7679366 complement(1700823..1701284) 1 NC_012466.1 identified by match to protein family HMM PF00571; CBS domain protein 1701284 7679366 SPJ_1783 Streptococcus pneumoniae JJA CBS domain protein YP_002736823.1 1700823 R 488222 CDS YP_002736824.1 225855312 7678885 complement(1701281..1701802) 1 NC_012466.1 identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040; phosphodiesterase, family 1701802 7678885 SPJ_1784 Streptococcus pneumoniae JJA phosphodiesterase, family YP_002736824.1 1701281 R 488222 CDS YP_002736825.1 225855313 7680235 complement(1701778..1702749) 1 NC_012466.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase/hypothetical protein 1702749 7680235 SPJ_1785 Streptococcus pneumoniae JJA deoxyribonucleotide triphosphate pyrophosphatase/hypothetical protein YP_002736825.1 1701778 R 488222 CDS YP_002736826.1 225855314 7680403 complement(1702746..1703540) 1 NC_012466.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1703540 murI 7680403 murI Streptococcus pneumoniae JJA glutamate racemase YP_002736826.1 1702746 R 488222 CDS YP_002736827.1 225855315 7679718 complement(1703747..1703995) 1 NC_012466.1 identified by match to protein family HMM PF03672; hypothetical protein 1703995 7679718 SPJ_1787 Streptococcus pneumoniae JJA hypothetical protein YP_002736827.1 1703747 R 488222 CDS YP_002736828.1 225855316 7680125 complement(1704251..1705876) 1 NC_012466.1 identified by match to protein family HMM PF00128; match to protein family HMM TIGR02403; alpha,alpha-phosphotrehalase 1705876 treC 7680125 treC Streptococcus pneumoniae JJA alpha,alpha-phosphotrehalase YP_002736828.1 1704251 R 488222 CDS YP_002736829.1 225855317 7679610 complement(1706054..1708021) 1 NC_012466.1 identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01992; pts system, trehalose-specific iibc component 1708021 treP 7679610 treP Streptococcus pneumoniae JJA pts system, trehalose-specific iibc component YP_002736829.1 1706054 R 488222 CDS YP_002736830.1 225855318 7680121 1708206..1708916 1 NC_012466.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM TIGR02404; trehalose operon repressor 1708916 treR 7680121 treR Streptococcus pneumoniae JJA trehalose operon repressor YP_002736830.1 1708206 D 488222 CDS YP_002736831.1 225855319 7678926 complement(1708949..1709752) 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1709752 7678926 SPJ_1791 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002736831.1 1708949 R 488222 CDS YP_002736832.1 225855320 7679258 complement(1709765..1710658) 1 NC_012466.1 identified by match to protein family HMM PF02653; ABC transporter permease 1710658 7679258 SPJ_1792 Streptococcus pneumoniae JJA ABC transporter permease YP_002736832.1 1709765 R 488222 CDS YP_002736833.1 225855321 7679893 complement(1710670..1711479) 1 NC_012466.1 identified by match to protein family HMM PF04392; ribose/xylose/arabinose/galactoside ABC-type transport system, permease component 1711479 7679893 SPJ_1793 Streptococcus pneumoniae JJA ribose/xylose/arabinose/galactoside ABC-type transport system, permease component YP_002736833.1 1710670 R 488222 CDS YP_002736834.1 225855322 7679677 1711572..1711700 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1711700 7679677 SPJ_1794 Streptococcus pneumoniae JJA hypothetical protein YP_002736834.1 1711572 D 488222 CDS YP_002736835.1 225855323 7680270 complement(1711900..1712031) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1712031 7680270 SPJ_1795 Streptococcus pneumoniae JJA hypothetical protein YP_002736835.1 1711900 R 488222 CDS YP_002736836.1 225855324 7678655 complement(1712097..1713023) 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08352; oligopeptide transport ATP-binding protein AmiF 1713023 7678655 SPJ_1796 Streptococcus pneumoniae JJA oligopeptide transport ATP-binding protein AmiF YP_002736836.1 1712097 R 488222 CDS YP_002736837.1 225855325 7679268 complement(1713034..1714101) 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; oligopeptide transport ATP-binding protein OppD 1714101 7679268 SPJ_1797 Streptococcus pneumoniae JJA oligopeptide transport ATP-binding protein OppD YP_002736837.1 1713034 R 488222 CDS YP_002736838.1 225855326 7678734 complement(1714110..1715036) 1 NC_012466.1 identified by match to protein family HMM PF00528; oligopeptide transport system permease protein AmiD 1715036 7678734 SPJ_1798 Streptococcus pneumoniae JJA oligopeptide transport system permease protein AmiD YP_002736838.1 1714110 R 488222 CDS YP_002736839.1 225855327 7680384 complement(1715036..1716532) 1 NC_012466.1 identified by match to protein family HMM PF00528; oligopeptide transport system permease protein AmiC 1716532 7680384 SPJ_1799 Streptococcus pneumoniae JJA oligopeptide transport system permease protein AmiC YP_002736839.1 1715036 R 488222 CDS YP_002736840.1 225855328 7680008 complement(1716599..1718578) 1 NC_012466.1 identified by match to protein family HMM PF00496; AmiA protein 1718578 7680008 SPJ_1800 Streptococcus pneumoniae JJA AmiA protein YP_002736840.1 1716599 R 488222 CDS YP_002736841.1 225855329 7680466 complement(1719264..1720457) 1 NC_012466.1 identified by match to protein family HMM PF04932; O-antigen polymerase family 1720457 7680466 SPJ_1801 Streptococcus pneumoniae JJA O-antigen polymerase family YP_002736841.1 1719264 R 488222 CDS YP_002736842.1 225855330 7680022 complement(1720595..1722037) 1 NC_012466.1 identified by match to protein family HMM PF00128; sucrose phosphorylase (Sucrose glucosyltransferase)(Glucosyltransferase-A) (GTF-A) 1722037 7680022 SPJ_1802 Streptococcus pneumoniae JJA sucrose phosphorylase (Sucrose glucosyltransferase)(Glucosyltransferase-A) (GTF-A) YP_002736842.1 1720595 R 488222 CDS YP_002736843.1 225855331 7678939 complement(1722221..1722388) 1 NC_012466.1 hypothetical protein 1722388 7678939 SPJ_1803 Streptococcus pneumoniae JJA hypothetical protein YP_002736843.1 1722221 R 488222 CDS YP_002736844.1 225855332 7678481 complement(1722395..1723228) 1 NC_012466.1 identified by match to protein family HMM PF00528; sugar ABC transporter permease 1723228 7678481 SPJ_1804 Streptococcus pneumoniae JJA sugar ABC transporter permease YP_002736844.1 1722395 R 488222 CDS YP_002736845.1 225855333 7680211 complement(1723242..1724108) 1 NC_012466.1 identified by match to protein family HMM PF00528; sugar ABC transporter permease 1724108 7680211 SPJ_1805 Streptococcus pneumoniae JJA sugar ABC transporter permease YP_002736845.1 1723242 R 488222 CDS YP_002736846.1 225855334 7680328 complement(1724122..1725381) 1 NC_012466.1 identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein 1725381 7680328 SPJ_1806 Streptococcus pneumoniae JJA sugar ABC transporter substrate-binding protein YP_002736846.1 1724122 R 488222 CDS YP_002736847.1 225855335 7679113 complement(1725473..1727635) 1 NC_012466.1 identified by match to protein family HMM PF02065; alpha-galactosidase AgaN 1727635 7679113 SPJ_1807 Streptococcus pneumoniae JJA alpha-galactosidase AgaN YP_002736847.1 1725473 R 488222 CDS YP_002736848.1 225855336 7679612 1727743..1728603 1 NC_012466.1 identified by match to protein family HMM PF00165; match to protein family HMM PF02311; Msm operon regulatory protein 1728603 7679612 SPJ_1808 Streptococcus pneumoniae JJA Msm operon regulatory protein YP_002736848.1 1727743 D 488222 CDS YP_002736849.1 225855337 7679056 1728600..1729535 1 NC_012466.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1729535 7679056 SPJ_1809 Streptococcus pneumoniae JJA biotin--protein ligase YP_002736849.1 1728600 D 488222 CDS YP_002736850.1 225855338 7679744 1729786..1730568 1 NC_012466.1 identified by match to protein family HMM PF01610; transposase 1730568 7679744 SPJ_1810 Streptococcus pneumoniae JJA transposase YP_002736850.1 1729786 D 488222 CDS YP_002736851.1 225855339 7680537 1730565..1731083 1 NC_012466.1 transposase 1731083 7680537 SPJ_1811 Streptococcus pneumoniae JJA transposase YP_002736851.1 1730565 D 488222 CDS YP_002736852.1 225855340 7680570 complement(1737927..1739282) 1 NC_012466.1 identified by match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA 1739282 rumA2 7680570 rumA2 Streptococcus pneumoniae JJA 23S rRNA (uracil-5-)-methyltransferase RumA YP_002736852.1 1737927 R 488222 CDS YP_002736853.1 225855341 7679989 1739320..1740096 1 NC_012466.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1740096 recX 7679989 recX Streptococcus pneumoniae JJA recombination regulator RecX YP_002736853.1 1739320 D 488222 CDS YP_002736854.1 225855342 7679725 1740185..1740718 1 NC_012466.1 identified by match to protein family HMM PF04167; hypothetical protein 1740718 7679725 SPJ_1836 Streptococcus pneumoniae JJA hypothetical protein YP_002736854.1 1740185 D 488222 CDS YP_002736855.1 225855343 7680219 complement(1741076..1741282) 1 NC_012466.1 identified by match to protein family HMM PF01610; hypothetical protein 1741282 7680219 SPJ_1837 Streptococcus pneumoniae JJA hypothetical protein YP_002736855.1 1741076 R 488222 CDS YP_002736856.1 225855344 7678934 1741442..1742224 1 NC_012466.1 identified by match to protein family HMM PF01610; transposase 1742224 7678934 SPJ_1838 Streptococcus pneumoniae JJA transposase YP_002736856.1 1741442 D 488222 CDS YP_002736857.1 225855345 7680475 1742221..1742748 1 NC_012466.1 transposase 1742748 7680475 SPJ_1839 Streptococcus pneumoniae JJA transposase YP_002736857.1 1742221 D 488222 CDS YP_002736858.1 225855346 7679997 complement(1742847..1744469) 1 NC_012466.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 1744469 groEL 7679997 groEL Streptococcus pneumoniae JJA chaperonin GroEL YP_002736858.1 1742847 R 488222 CDS YP_002736859.1 225855347 7678946 complement(1744485..1744769) 1 NC_012466.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1744769 groES 7678946 groES Streptococcus pneumoniae JJA co-chaperonin GroES YP_002736859.1 1744485 R 488222 CDS YP_002736860.1 225855348 7678446 complement(1744925..1745302) 1 NC_012466.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1745302 7678446 SPJ_1842 Streptococcus pneumoniae JJA single-stranded DNA-binding protein YP_002736860.1 1744925 R 488222 CDS YP_002736861.1 225855349 7680185 complement(1745329..1745571) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1745571 7680185 SPJ_1843 Streptococcus pneumoniae JJA hypothetical protein YP_002736861.1 1745329 R 488222 CDS YP_002736862.1 225855350 7679694 complement(1745803..1746759) 1 NC_012466.1 identified by match to protein family HMM PF01473; match to protein family HMM PF01510; autolysin (N-acetylmuramoyl-L-alanine amidase) (Mureinhydrolase) (Mucopeptide aminohydrolase) (Cell wall hydrolase) 1746759 7679694 SPJ_1844 Streptococcus pneumoniae JJA autolysin (N-acetylmuramoyl-L-alanine amidase) (Mureinhydrolase) (Mucopeptide aminohydrolase) (Cell wall hydrolase) YP_002736862.1 1745803 R 488222 CDS YP_002736863.1 225855351 7678665 complement(1746765..1747094) 1 NC_012466.1 identified by match to protein family HMM TIGR01673; phage holin, LL-H family 1747094 7678665 SPJ_1845 Streptococcus pneumoniae JJA phage holin, LL-H family YP_002736863.1 1746765 R 488222 CDS YP_002736864.1 225855352 7680491 complement(1747098..1747397) 1 NC_012466.1 hypothetical protein 1747397 7680491 SPJ_1846 Streptococcus pneumoniae JJA hypothetical protein YP_002736864.1 1747098 R 488222 CDS YP_002736865.1 225855353 7679958 complement(1747407..1747757) 1 NC_012466.1 hypothetical protein 1747757 7679958 SPJ_1847 Streptococcus pneumoniae JJA hypothetical protein YP_002736865.1 1747407 R 488222 CDS YP_002736866.1 225855354 7679550 complement(1747760..1747963) 1 NC_012466.1 hypothetical protein 1747963 7679550 SPJ_1848 Streptococcus pneumoniae JJA hypothetical protein YP_002736866.1 1747760 R 488222 CDS YP_002736867.1 225855355 7678991 complement(1747944..1748060) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1748060 7678991 SPJ_1849 Streptococcus pneumoniae JJA hypothetical protein YP_002736867.1 1747944 R 488222 CDS YP_002736868.1 225855356 7678871 complement(1748057..1754383) 1 NC_012466.1 identified by match to protein family HMM PF02018; PblB 1754383 7678871 SPJ_1850 Streptococcus pneumoniae JJA PblB YP_002736868.1 1748057 R 488222 CDS YP_002736869.1 225855357 7678857 complement(1754388..1754738) 1 NC_012466.1 hypothetical protein 1754738 7678857 SPJ_1851 Streptococcus pneumoniae JJA hypothetical protein YP_002736869.1 1754388 R 488222 CDS YP_002736870.1 225855358 7679507 complement(1754747..1758400) 1 NC_012466.1 TMP repeat family 1758400 7679507 SPJ_1852 Streptococcus pneumoniae JJA TMP repeat family YP_002736870.1 1754747 R 488222 CDS YP_002736871.1 225855359 7679027 complement(1758387..1758737) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1758737 7679027 SPJ_1853 Streptococcus pneumoniae JJA hypothetical protein YP_002736871.1 1758387 R 488222 CDS YP_002736872.1 225855360 7678643 complement(1758776..1759156) 1 NC_012466.1 hypothetical protein 1759156 7678643 SPJ_1854 Streptococcus pneumoniae JJA hypothetical protein YP_002736872.1 1758776 R 488222 CDS YP_002736873.1 225855361 7678604 complement(1759161..1759574) 1 NC_012466.1 major tail protein, putative 1759574 7678604 SPJ_1855 Streptococcus pneumoniae JJA major tail protein, putative YP_002736873.1 1759161 R 488222 CDS YP_002736874.1 225855362 7680359 complement(1759577..1759945) 1 NC_012466.1 conserved structural protein, putative 1759945 7680359 SPJ_1856 Streptococcus pneumoniae JJA conserved structural protein, putative YP_002736874.1 1759577 R 488222 CDS YP_002736875.1 225855363 7679885 complement(1759942..1760268) 1 NC_012466.1 hypothetical protein 1760268 7679885 SPJ_1857 Streptococcus pneumoniae JJA hypothetical protein YP_002736875.1 1759942 R 488222 CDS YP_002736876.1 225855364 7679720 complement(1760432..1760734) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1760734 7679720 SPJ_1858 Streptococcus pneumoniae JJA hypothetical protein YP_002736876.1 1760432 R 488222 CDS YP_002736877.1 225855365 7679019 complement(1760751..1761062) 1 NC_012466.1 hypothetical protein 1761062 7679019 SPJ_1859 Streptococcus pneumoniae JJA hypothetical protein YP_002736877.1 1760751 R 488222 CDS YP_002736878.1 225855366 7679663 complement(1761064..1761252) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1761252 7679663 SPJ_1860 Streptococcus pneumoniae JJA hypothetical protein YP_002736878.1 1761064 R 488222 CDS YP_002736879.1 225855367 7678782 complement(1761242..1761424) 1 NC_012466.1 identified by match to protein family HMM PF07498; transcription termination factor 1761424 7678782 SPJ_1861 Streptococcus pneumoniae JJA transcription termination factor YP_002736879.1 1761242 R 488222 CDS YP_002736880.1 225855368 7679274 complement(1761436..1762281) 1 NC_012466.1 MHP 1762281 7679274 SPJ_1862 Streptococcus pneumoniae JJA MHP YP_002736880.1 1761436 R 488222 CDS YP_002736881.1 225855369 7679373 complement(1762287..1762871) 1 NC_012466.1 phage scaffold protein 1762871 7679373 SPJ_1863 Streptococcus pneumoniae JJA phage scaffold protein YP_002736881.1 1762287 R 488222 CDS YP_002736882.1 225855370 7679839 complement(1763088..1763339) 1 NC_012466.1 gp37 1763339 7679839 SPJ_1864 Streptococcus pneumoniae JJA gp37 YP_002736882.1 1763088 R 488222 CDS YP_002736883.1 225855371 7680165 complement(1763341..1763586) 1 NC_012466.1 hypothetical protein 1763586 7680165 SPJ_1865 Streptococcus pneumoniae JJA hypothetical protein YP_002736883.1 1763341 R 488222 CDS YP_002736884.1 225855372 7678423 complement(1763629..1764042) 1 NC_012466.1 identified by match to protein family HMM PF01966; metal dependent phosphohydrolase, HD region 1764042 7678423 SPJ_1866 Streptococcus pneumoniae JJA metal dependent phosphohydrolase, HD region YP_002736884.1 1763629 R 488222 CDS YP_002736885.1 225855373 7678572 complement(1764039..1764248) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1764248 7678572 SPJ_1867 Streptococcus pneumoniae JJA hypothetical protein YP_002736885.1 1764039 R 488222 CDS YP_002736886.1 225855374 7679653 complement(1764250..1765833) 1 NC_012466.1 identified by match to protein family HMM PF04233; match to protein family HMM TIGR01641; phage putative head morphogenesis protein, SPP1 gp7 family 1765833 7679653 SPJ_1868 Streptococcus pneumoniae JJA phage putative head morphogenesis protein, SPP1 gp7 family YP_002736886.1 1764250 R 488222 CDS YP_002736887.1 225855375 7679320 complement(1765796..1767097) 1 NC_012466.1 identified by match to protein family HMM PF05133; match to protein family HMM TIGR01538; phage portal protein, SPP1 family 1767097 7679320 SPJ_1869 Streptococcus pneumoniae JJA phage portal protein, SPP1 family YP_002736887.1 1765796 R 488222 CDS YP_002736888.1 225855376 7678712 complement(1767277..1768575) 1 NC_012466.1 identified by match to protein family HMM PF04466; match to protein family HMM PF07570; match to protein family HMM TIGR01547; phage terminase, large subunit, pbsx family 1768575 7678712 SPJ_1870 Streptococcus pneumoniae JJA phage terminase, large subunit, pbsx family YP_002736888.1 1767277 R 488222 CDS YP_002736889.1 225855377 7680534 complement(1768553..1769053) 1 NC_012466.1 identified by match to protein family HMM PF03592; phage terminase small subunit 1769053 7680534 SPJ_1871 Streptococcus pneumoniae JJA phage terminase small subunit YP_002736889.1 1768553 R 488222 CDS YP_002736890.1 225855378 7680561 complement(1769461..1769865) 1 NC_012466.1 phage protein 1769865 7680561 SPJ_1873 Streptococcus pneumoniae JJA phage protein YP_002736890.1 1769461 R 488222 CDS YP_002736891.1 225855379 7679434 complement(1770306..1770743) 1 NC_012466.1 identified by match to protein family HMM TIGR01671; hypothetical protein 1770743 7679434 SPJ_1874 Streptococcus pneumoniae JJA hypothetical protein YP_002736891.1 1770306 R 488222 CDS YP_002736892.1 225855380 7678949 complement(1770755..1771177) 1 NC_012466.1 hypothetical protein 1771177 7678949 SPJ_1875 Streptococcus pneumoniae JJA hypothetical protein YP_002736892.1 1770755 R 488222 CDS YP_002736893.1 225855381 7678623 complement(1771431..1771592) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1771592 7678623 SPJ_1876 Streptococcus pneumoniae JJA hypothetical protein YP_002736893.1 1771431 R 488222 CDS YP_002736894.1 225855382 7679904 complement(1771592..1772284) 1 NC_012466.1 identified by match to protein family HMM PF07852; hypothetical protein 1772284 7679904 SPJ_1877 Streptococcus pneumoniae JJA hypothetical protein YP_002736894.1 1771592 R 488222 CDS YP_002736895.1 225855383 7679665 complement(1772286..1772603) 1 NC_012466.1 gp24 1772603 7679665 SPJ_1878 Streptococcus pneumoniae JJA gp24 YP_002736895.1 1772286 R 488222 CDS YP_002736896.1 225855384 7679668 complement(1772826..1773257) 1 NC_012466.1 identified by match to protein family HMM PF05866; holliday junction resolvase 1773257 7679668 SPJ_1879 Streptococcus pneumoniae JJA holliday junction resolvase YP_002736896.1 1772826 R 488222 CDS YP_002736897.1 225855385 7679576 complement(1773254..1773652) 1 NC_012466.1 phage protein 1773652 7679576 SPJ_1880 Streptococcus pneumoniae JJA phage protein YP_002736897.1 1773254 R 488222 CDS YP_002736898.1 225855386 7680044 complement(1773665..1774081) 1 NC_012466.1 identified by match to protein family HMM PF00436; match to protein family HMM TIGR00621; single-strand binding protein family 1774081 7680044 SPJ_1881 Streptococcus pneumoniae JJA single-strand binding protein family YP_002736898.1 1773665 R 488222 CDS YP_002736899.1 225855387 7678657 complement(1774078..1774194) 1 NC_012466.1 hypothetical protein 1774194 7678657 SPJ_1882 Streptococcus pneumoniae JJA hypothetical protein YP_002736899.1 1774078 R 488222 CDS YP_002736900.1 225855388 7679119 complement(1774504..1774992) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1774992 7679119 SPJ_1883 Streptococcus pneumoniae JJA hypothetical protein YP_002736900.1 1774504 R 488222 CDS YP_002736901.1 225855389 7680268 complement(1774995..1776059) 1 NC_012466.1 identified by match to protein family HMM PF07083; phage protein 1776059 7680268 SPJ_1884 Streptococcus pneumoniae JJA phage protein YP_002736901.1 1774995 R 488222 CDS YP_002736902.1 225855390 7678688 complement(1776069..1776887) 1 NC_012466.1 identified by match to protein family HMM PF03837; match to protein family HMM TIGR01913; phage recombination protein Bet 1776887 bet 7678688 bet Streptococcus pneumoniae JJA phage recombination protein Bet YP_002736902.1 1776069 R 488222 CDS YP_002736903.1 225855391 7679344 complement(1776924..1777040) 1 NC_012466.1 hypothetical protein 1777040 7679344 SPJ_1886 Streptococcus pneumoniae JJA hypothetical protein YP_002736903.1 1776924 R 488222 CDS YP_002736904.1 225855392 7679956 complement(1777157..1777417) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1777417 7679956 SPJ_1887 Streptococcus pneumoniae JJA hypothetical protein YP_002736904.1 1777157 R 488222 CDS YP_002736905.1 225855393 7679817 complement(1777430..1777684) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1777684 7679817 SPJ_1888 Streptococcus pneumoniae JJA hypothetical protein YP_002736905.1 1777430 R 488222 CDS YP_002736906.1 225855394 7680417 complement(1777685..1777906) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1777906 7680417 SPJ_1889 Streptococcus pneumoniae JJA hypothetical protein YP_002736906.1 1777685 R 488222 CDS YP_002736907.1 225855395 7678696 complement(1777906..1778043) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1778043 7678696 SPJ_1890 Streptococcus pneumoniae JJA hypothetical protein YP_002736907.1 1777906 R 488222 CDS YP_002736908.1 225855396 7679184 complement(1778061..1778858) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1778858 7679184 SPJ_1891 Streptococcus pneumoniae JJA hypothetical protein YP_002736908.1 1778061 R 488222 CDS YP_002736909.1 225855397 7679680 complement(1778925..1779068) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1779068 7679680 SPJ_1892 Streptococcus pneumoniae JJA hypothetical protein YP_002736909.1 1778925 R 488222 CDS YP_002736910.1 225855398 7680159 1779185..1779409 1 NC_012466.1 hypothetical protein 1779409 7680159 SPJ_1894 Streptococcus pneumoniae JJA hypothetical protein YP_002736910.1 1779185 D 488222 CDS YP_002736911.1 225855399 7679968 complement(1779406..1779588) 1 NC_012466.1 hypothetical protein 1779588 7679968 SPJ_1893 Streptococcus pneumoniae JJA hypothetical protein YP_002736911.1 1779406 R 488222 CDS YP_002736912.1 225855400 7678447 complement(1779773..1780051) 1 NC_012466.1 phage replication protein 1780051 7678447 SPJ_1895 Streptococcus pneumoniae JJA phage replication protein YP_002736912.1 1779773 R 488222 CDS YP_002736913.1 225855401 7678865 complement(1780218..1780454) 1 NC_012466.1 phage protein 1780454 7678865 SPJ_1896 Streptococcus pneumoniae JJA phage protein YP_002736913.1 1780218 R 488222 CDS YP_002736914.1 225855402 7680331 1780528..1780734 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1780734 7680331 SPJ_1897 Streptococcus pneumoniae JJA hypothetical protein YP_002736914.1 1780528 D 488222 CDS YP_002736915.1 225855403 7679827 1781135..1781584 1 NC_012466.1 phage protein 1781584 7679827 SPJ_1899 Streptococcus pneumoniae JJA phage protein YP_002736915.1 1781135 D 488222 CDS YP_002736916.1 225855404 7679218 complement(1781575..1781706) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1781706 7679218 SPJ_1898 Streptococcus pneumoniae JJA hypothetical protein YP_002736916.1 1781575 R 488222 CDS YP_002736917.1 225855405 7678762 complement(1781817..1782092) 1 NC_012466.1 hypothetical protein 1782092 7678762 SPJ_1900 Streptococcus pneumoniae JJA hypothetical protein YP_002736917.1 1781817 R 488222 CDS YP_002736918.1 225855406 7678725 1782253..1783005 1 NC_012466.1 identified by match to protein family HMM PF00717; match to protein family HMM PF01381; cI repressor 1783005 7678725 SPJ_1901 Streptococcus pneumoniae JJA cI repressor YP_002736918.1 1782253 D 488222 CDS YP_002736919.1 225855407 7680486 complement(1783143..1783313) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1783313 7680486 SPJ_1902 Streptococcus pneumoniae JJA hypothetical protein YP_002736919.1 1783143 R 488222 CDS YP_002736920.1 225855408 7680010 1783389..1784816 1 NC_012466.1 identified by match to protein family HMM PF00239; match to protein family HMM PF07508; INT 1784816 7680010 SPJ_1903 Streptococcus pneumoniae JJA INT YP_002736920.1 1783389 D 488222 CDS YP_002736921.1 225855409 7678963 complement(1784952..1785713) 1 NC_012466.1 identified by match to protein family HMM PF00106; match to protein family HMM PF08659; oxidoreductase, short chain dehydrogenase/reductase family 1785713 7678963 SPJ_1904 Streptococcus pneumoniae JJA oxidoreductase, short chain dehydrogenase/reductase family YP_002736921.1 1784952 R 488222 CDS YP_002736922.1 225855410 7678492 complement(1785755..1786381) 1 NC_012466.1 identified by match to protein family HMM PF01588; putative tRNA binding domain protein 1786381 7678492 SPJ_1905 Streptococcus pneumoniae JJA putative tRNA binding domain protein YP_002736922.1 1785755 R 488222 CDS YP_002736923.1 225855411 7678717 complement(1786397..1786714) 1 NC_012466.1 identified by match to protein family HMM PF00085; thioredoxin family protein 1786714 7678717 SPJ_1906 Streptococcus pneumoniae JJA thioredoxin family protein YP_002736923.1 1786397 R 488222 CDS YP_002736924.1 225855412 7679749 complement(1786711..1787001) 1 NC_012466.1 hypothetical protein 1787001 7679749 SPJ_1907 Streptococcus pneumoniae JJA hypothetical protein YP_002736924.1 1786711 R 488222 CDS YP_002736925.1 225855413 7678875 complement(1787295..1787438) 1 NC_012466.1 identified by match to protein family HMM PF01473; hypothetical protein 1787438 7678875 SPJ_1908 Streptococcus pneumoniae JJA hypothetical protein YP_002736925.1 1787295 R 488222 CDS YP_002736926.1 225855414 7679357 complement(1787647..1788321) 1 NC_012466.1 hypothetical protein 1788321 7679357 SPJ_1909 Streptococcus pneumoniae JJA hypothetical protein YP_002736926.1 1787647 R 488222 CDS YP_002736927.1 225855415 7680134 complement(1788327..1788773) 1 NC_012466.1 identified by match to protein family HMM PF04397; response regulator of the LytR/AlgR family 1788773 7680134 SPJ_1910 Streptococcus pneumoniae JJA response regulator of the LytR/AlgR family YP_002736927.1 1788327 R 488222 CDS YP_002736928.1 225855416 7678407 complement(1788887..1789390) 1 NC_012466.1 identified by match to protein family HMM PF01569; PAP2 family protein 1789390 7678407 SPJ_1911 Streptococcus pneumoniae JJA PAP2 family protein YP_002736928.1 1788887 R 488222 CDS YP_002736929.1 225855417 7678648 complement(1789387..1789749) 1 NC_012466.1 hypothetical protein 1789749 7678648 SPJ_1912 Streptococcus pneumoniae JJA hypothetical protein YP_002736929.1 1789387 R 488222 CDS YP_002736930.1 225855418 7678405 complement(1792286..1793002) 1 NC_012466.1 identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein 1793002 7678405 SPJ_1919 Streptococcus pneumoniae JJA hypothetical protein YP_002736930.1 1792286 R 488222 CDS YP_002736931.1 225855419 7679124 complement(1793883..1795298) 1 NC_012466.1 identified by match to protein family HMM PF01289; pneumolysin (Thiol-activated cytolysin) 1795298 7679124 SPJ_1920 Streptococcus pneumoniae JJA pneumolysin (Thiol-activated cytolysin) YP_002736931.1 1793883 R 488222 CDS YP_002736932.1 225855420 7680308 complement(1795309..1795719) 1 NC_012466.1 hypothetical protein 1795719 7680308 SPJ_1921 Streptococcus pneumoniae JJA hypothetical protein YP_002736932.1 1795309 R 488222 CDS YP_002736933.1 225855421 7680090 complement(1795712..1796320) 1 NC_012466.1 hypothetical protein 1796320 7680090 SPJ_1922 Streptococcus pneumoniae JJA hypothetical protein YP_002736933.1 1795712 R 488222 CDS YP_002736934.1 225855422 7678503 complement(1796333..1796791) 1 NC_012466.1 hypothetical protein 1796791 7678503 SPJ_1923 Streptococcus pneumoniae JJA hypothetical protein YP_002736934.1 1796333 R 488222 CDS YP_002736935.1 225855423 7679948 1796916..1797047 1 NC_012466.1 mobile genetic element 1797047 7679948 SPJ_1924 Streptococcus pneumoniae JJA mobile genetic element YP_002736935.1 1796916 D 488222 CDS YP_002736936.1 225855424 7680527 1797052..1797369 1 NC_012466.1 mobile genetic element 1797369 7680527 SPJ_1925 Streptococcus pneumoniae JJA mobile genetic element YP_002736936.1 1797052 D 488222 CDS YP_002736937.1 225855425 7678680 complement(1798053..1798313) 1 NC_012466.1 hypothetical protein 1798313 7678680 SPJ_1926 Streptococcus pneumoniae JJA hypothetical protein YP_002736937.1 1798053 R 488222 CDS YP_002736938.1 225855426 7679330 complement(1798372..1798923) 1 NC_012466.1 hypothetical protein 1798923 7679330 SPJ_1927 Streptococcus pneumoniae JJA hypothetical protein YP_002736938.1 1798372 R 488222 CDS YP_002736939.1 225855427 7679079 complement(1798913..1799698) 1 NC_012466.1 hypothetical protein 1799698 7679079 SPJ_1928 Streptococcus pneumoniae JJA hypothetical protein YP_002736939.1 1798913 R 488222 CDS YP_002736940.1 225855428 7679042 complement(1800300..1800521) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1800521 7679042 SPJ_1929 Streptococcus pneumoniae JJA hypothetical protein YP_002736940.1 1800300 R 488222 CDS YP_002736941.1 225855429 7678431 complement(1800650..1801009) 1 NC_012466.1 hypothetical protein 1801009 7678431 SPJ_1930 Streptococcus pneumoniae JJA hypothetical protein YP_002736941.1 1800650 R 488222 CDS YP_002736942.1 225855430 7678829 complement(1801248..1801409) 1 NC_012466.1 type II restriction-modification system regulatory protein, putative 1801409 7678829 SPJ_1931 Streptococcus pneumoniae JJA type II restriction-modification system regulatory protein, putative YP_002736942.1 1801248 R 488222 CDS YP_002736943.1 225855431 7679853 complement(1801755..1802711) 1 NC_012466.1 identified by match to protein family HMM PF01473; match to protein family HMM PF01510; autolysin (N-acetylmuramoyl-L-alanine amidase) (Mureinhydrolase) (Mucopeptide aminohydrolase) (Cell wall hydrolase) 1802711 7679853 SPJ_1932 Streptococcus pneumoniae JJA autolysin (N-acetylmuramoyl-L-alanine amidase) (Mureinhydrolase) (Mucopeptide aminohydrolase) (Cell wall hydrolase) YP_002736943.1 1801755 R 488222 CDS YP_002736944.1 225855432 7679224 complement(1803087..1804457) 1 NC_012466.1 identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; DNA-damage-inducible protein 1804457 7679224 SPJ_1933 Streptococcus pneumoniae JJA DNA-damage-inducible protein YP_002736944.1 1803087 R 488222 CDS YP_002736945.1 225855433 7678619 complement(1804764..1805930) 1 NC_012466.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1805930 recA 7678619 recA Streptococcus pneumoniae JJA recombinase A YP_002736945.1 1804764 R 488222 CDS YP_002736946.1 225855434 7680195 complement(1805985..1807241) 1 NC_012466.1 identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; competence damage-inducible protein A 1807241 7680195 SPJ_1935 Streptococcus pneumoniae JJA competence damage-inducible protein A YP_002736946.1 1805985 R 488222 CDS YP_002736947.1 225855435 7679103 complement(1807326..1808342) 1 NC_012466.1 identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; regulator of lytrabc operon 1808342 7679103 SPJ_1936 Streptococcus pneumoniae JJA regulator of lytrabc operon YP_002736947.1 1807326 R 488222 CDS YP_002736948.1 225855436 7678517 complement(1808350..1808868) 1 NC_012466.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 1808868 7678517 SPJ_1937 Streptococcus pneumoniae JJA acetyltransferase, gnat family YP_002736948.1 1808350 R 488222 CDS YP_002736949.1 225855437 7680102 complement(1808858..1809301) 1 NC_012466.1 identified by match to protein family HMM PF02367; match to protein family HMM TIGR00150; hypothetical protein 1809301 7680102 SPJ_1938 Streptococcus pneumoniae JJA hypothetical protein YP_002736949.1 1808858 R 488222 CDS YP_002736950.1 225855438 7679383 complement(1809387..1810007) 1 NC_012466.1 lipoprotein, putative 1810007 7679383 SPJ_1939 Streptococcus pneumoniae JJA lipoprotein, putative YP_002736950.1 1809387 R 488222 CDS YP_002736951.1 225855439 7678932 complement(1810390..1811253) 1 NC_012466.1 identified by match to protein family HMM PF01381; transcriptional activator 1811253 7678932 SPJ_1940 Streptococcus pneumoniae JJA transcriptional activator YP_002736951.1 1810390 R 488222 CDS YP_002736952.1 225855440 7679350 1811502..1811615 1 NC_012466.1 hypothetical protein 1811615 7679350 SPJ_1941 Streptococcus pneumoniae JJA hypothetical protein YP_002736952.1 1811502 D 488222 CDS YP_002736953.1 225855441 7678874 1811718..1811942 1 NC_012466.1 hypothetical protein 1811942 7678874 SPJ_1942 Streptococcus pneumoniae JJA hypothetical protein YP_002736953.1 1811718 D 488222 CDS YP_002736954.1 225855442 7680360 1811949..1812137 1 NC_012466.1 hypothetical protein 1812137 7680360 SPJ_1943 Streptococcus pneumoniae JJA hypothetical protein YP_002736954.1 1811949 D 488222 CDS YP_002736955.1 225855443 7679837 1812254..1815244 1 NC_012466.1 identified by match to protein family HMM PF05147; CylM protein, cytolytic toxin system 1815244 7679837 SPJ_1944 Streptococcus pneumoniae JJA CylM protein, cytolytic toxin system YP_002736955.1 1812254 D 488222 CDS YP_002736956.1 225855444 7679644 1815594..1816298 1 NC_012466.1 hypothetical protein 1816298 7679644 SPJ_1945 Streptococcus pneumoniae JJA hypothetical protein YP_002736956.1 1815594 D 488222 CDS YP_002736957.1 225855445 7679146 1816279..1817208 1 NC_012466.1 hypothetical protein 1817208 7679146 SPJ_1946 Streptococcus pneumoniae JJA hypothetical protein YP_002736957.1 1816279 D 488222 CDS YP_002736958.1 225855446 7678583 1817205..1819313 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; toxin secretion ABC transporter, ATP-binding/permease protein 1819313 7678583 SPJ_1947 Streptococcus pneumoniae JJA toxin secretion ABC transporter, ATP-binding/permease protein YP_002736958.1 1817205 D 488222 CDS YP_002736959.1 225855447 7680157 1819337..1821076 1 NC_012466.1 identified by match to protein family HMM PF00082; serine protease subtilase family protein 1821076 7680157 SPJ_1948 Streptococcus pneumoniae JJA serine protease subtilase family protein YP_002736959.1 1819337 D 488222 CDS YP_002736960.1 225855448 7679916 1821127..1821894 1 NC_012466.1 identified by match to protein family HMM PF07242; hypothetical protein 1821894 7679916 SPJ_1949 Streptococcus pneumoniae JJA hypothetical protein YP_002736960.1 1821127 D 488222 CDS YP_002736961.1 225855449 7679405 1821896..1822528 1 NC_012466.1 identified by match to protein family HMM PF00005; antimicrobial peptide ABC transporter ATPase 1822528 7679405 SPJ_1950 Streptococcus pneumoniae JJA antimicrobial peptide ABC transporter ATPase YP_002736961.1 1821896 D 488222 CDS YP_002736962.1 225855450 7678518 1822669..1822947 1 NC_012466.1 hypothetical protein 1822947 7678518 SPJ_1951 Streptococcus pneumoniae JJA hypothetical protein YP_002736962.1 1822669 D 488222 CDS YP_002736963.1 225855451 7680259 complement(1823457..1823870) 1 NC_012466.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1823870 ndk 7680259 ndk Streptococcus pneumoniae JJA nucleoside diphosphate kinase YP_002736963.1 1823457 R 488222 CDS YP_002736964.1 225855452 7680260 complement(1823981..1827658) 1 NC_012466.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 1827658 rpoC 7680260 rpoC Streptococcus pneumoniae JJA DNA-directed RNA polymerase subunit beta' YP_002736964.1 1823981 R 488222 CDS YP_002736965.1 225855453 7679628 complement(1827691..1831302) 1 NC_012466.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1831302 rpoB 7679628 rpoB Streptococcus pneumoniae JJA DNA-directed RNA polymerase subunit beta YP_002736965.1 1827691 R 488222 CDS YP_002736966.1 225855454 7680590 complement(1831986..1833317) 1 NC_012466.1 identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471; hemolysin 1833317 7680590 SPJ_1956 Streptococcus pneumoniae JJA hemolysin YP_002736966.1 1831986 R 488222 CDS YP_002736967.1 225855455 7680352 complement(1833546..1834370) 1 NC_012466.1 identified by match to protein family HMM PF01223; DNA-entry nuclease (Competence-specific nuclease) 1834370 7680352 SPJ_1957 Streptococcus pneumoniae JJA DNA-entry nuclease (Competence-specific nuclease) YP_002736967.1 1833546 R 488222 CDS YP_002736968.1 225855456 7679450 complement(1834409..1834603) 1 NC_012466.1 hypothetical protein 1834603 7679450 SPJ_1958 Streptococcus pneumoniae JJA hypothetical protein YP_002736968.1 1834409 R 488222 CDS YP_002736969.1 225855457 7678430 complement(1834590..1835873) 1 NC_012466.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1835873 murA2 7678430 murA2 Streptococcus pneumoniae JJA UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002736969.1 1834590 R 488222 CDS YP_002736970.1 225855458 7680515 complement(1835897..1836094) 1 NC_012466.1 identified by match to protein family HMM TIGR02327; hypothetical protein 1836094 7680515 SPJ_1960 Streptococcus pneumoniae JJA hypothetical protein YP_002736970.1 1835897 R 488222 CDS YP_002736971.1 225855459 7679892 complement(1836185..1837222) 1 NC_012466.1 ATP-dependent protease La 1837222 7679892 SPJ_1961 Streptococcus pneumoniae JJA ATP-dependent protease La YP_002736971.1 1836185 R 488222 CDS YP_002736972.1 225855460 7679280 complement(1837206..1837694) 1 NC_012466.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1837694 coaD 7679280 coaD Streptococcus pneumoniae JJA phosphopantetheine adenylyltransferase YP_002736972.1 1837206 R 488222 CDS YP_002736973.1 225855461 7678660 complement(1837684..1838223) 1 NC_012466.1 identified by match to protein family HMM PF03602; match to protein family HMM TIGR00095; RNA methyltransferase, RsmD family 1838223 rsmD 7678660 rsmD Streptococcus pneumoniae JJA RNA methyltransferase, RsmD family YP_002736973.1 1837684 R 488222 CDS YP_002736974.1 225855462 7680508 complement(1838288..1839280) 1 NC_012466.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 1839280 asnA 7680508 asnA Streptococcus pneumoniae JJA asparagine synthetase AsnA YP_002736974.1 1838288 R 488222 CDS YP_002736975.1 225855463 7679960 complement(1839392..1840075) 1 NC_012466.1 identified by match to protein family HMM PF01027; membrane protein 1840075 7679960 SPJ_1965 Streptococcus pneumoniae JJA membrane protein YP_002736975.1 1839392 R 488222 CDS YP_002736976.1 225855464 7678414 1840904..1841182 1 NC_012466.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1841182 7678414 SPJ_1967 Streptococcus pneumoniae JJA acylphosphatase YP_002736976.1 1840904 D 488222 CDS YP_002736977.1 225855465 7680243 1841260..1842186 1 NC_012466.1 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor 1842186 7680243 SPJ_1968 Streptococcus pneumoniae JJA OxaA-like protein precursor YP_002736977.1 1841260 D 488222 CDS YP_002736978.1 225855466 7679661 complement(1842261..1843055) 1 NC_012466.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR02493; pyruvate formate-lyase 1-activating enzyme 1843055 pflA 7679661 pflA Streptococcus pneumoniae JJA pyruvate formate-lyase 1-activating enzyme YP_002736978.1 1842261 R 488222 CDS YP_002736979.1 225855467 7680436 complement(1843181..1844431) 1 NC_012466.1 identified by match to protein family HMM PF00278; match to protein family HMM PF02784; diaminopimelate decarboxylase 1844431 7680436 SPJ_1970 Streptococcus pneumoniae JJA diaminopimelate decarboxylase YP_002736979.1 1843181 R 488222 CDS YP_002736980.1 225855468 7678784 complement(1844498..1845325) 1 NC_012466.1 identified by match to protein family HMM PF00156; match to protein family HMM PF09182; match to protein family HMM TIGR01743; pur operon repressor 1845325 purR 7678784 purR Streptococcus pneumoniae JJA pur operon repressor YP_002736980.1 1844498 R 488222 CDS YP_002736981.1 225855469 7678386 complement(1845592..1846533) 1 NC_012466.1 identified by match to protein family HMM PF01336; match to protein family HMM PF01966; 3'-5' exoribonuclease YhaM 1846533 7678386 SPJ_1972 Streptococcus pneumoniae JJA 3'-5' exoribonuclease YhaM YP_002736981.1 1845592 R 488222 CDS YP_002736982.1 225855470 7678973 complement(1846523..1847779) 1 NC_012466.1 identified by match to protein family HMM PF02646; competence-induced protein Ccs50 1847779 7678973 SPJ_1973 Streptococcus pneumoniae JJA competence-induced protein Ccs50 YP_002736982.1 1846523 R 488222 CDS YP_002736983.1 225855471 7679759 complement(1847781..1848443) 1 NC_012466.1 identified by match to protein family HMM PF04263; match to protein family HMM PF04265; match to protein family HMM TIGR01378; thiamine pyrophosphokinase 1848443 7679759 SPJ_1974 Streptococcus pneumoniae JJA thiamine pyrophosphokinase YP_002736983.1 1847781 R 488222 CDS YP_002736984.1 225855472 7680207 complement(1848406..1849062) 1 NC_012466.1 identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163; ribulose-phosphate 3-epimerase 1849062 rpe 7680207 rpe Streptococcus pneumoniae JJA ribulose-phosphate 3-epimerase YP_002736984.1 1848406 R 488222 CDS YP_002736985.1 225855473 7678732 complement(1849073..1849951) 1 NC_012466.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 1849951 rsgA 7678732 rsgA Streptococcus pneumoniae JJA ribosome-associated GTPase YP_002736985.1 1849073 R 488222 CDS YP_002736986.1 225855474 7679226 complement(1849953..1850825) 1 NC_012466.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1850825 ksgA 7679226 ksgA Streptococcus pneumoniae JJA dimethyladenosine transferase YP_002736986.1 1849953 R 488222 CDS YP_002736987.1 225855475 7678843 complement(1851076..1851369) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1851369 7678843 SPJ_1978 Streptococcus pneumoniae JJA hypothetical protein YP_002736987.1 1851076 R 488222 CDS YP_002736988.1 225855476 7679216 complement(1851362..1852003) 1 NC_012466.1 identified by match to protein family HMM PF00005; antimicrobial peptide ABC transporter ATPase 1852003 7679216 SPJ_1979 Streptococcus pneumoniae JJA antimicrobial peptide ABC transporter ATPase YP_002736988.1 1851362 R 488222 CDS YP_002736989.1 225855477 7680193 complement(1852005..1854035) 1 NC_012466.1 identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; immunity protein, putative 1854035 7680193 SPJ_1980 Streptococcus pneumoniae JJA immunity protein, putative YP_002736989.1 1852005 R 488222 CDS YP_002736990.1 225855478 7679518 complement(1854112..1854408) 1 NC_012466.1 identified by match to protein family HMM TIGR01653; bacteriocin, lactococcin 972 family 1854408 7679518 SPJ_1981 Streptococcus pneumoniae JJA bacteriocin, lactococcin 972 family YP_002736990.1 1854112 R 488222 CDS YP_002736991.1 225855479 7678402 complement(1854728..1855627) 1 NC_012466.1 transcriptional activator 1855627 7678402 SPJ_1982 Streptococcus pneumoniae JJA transcriptional activator YP_002736991.1 1854728 R 488222 CDS YP_002736992.1 225855480 7680241 complement(1855699..1856259) 1 NC_012466.1 identified by match to protein family HMM PF01751; match to protein family HMM TIGR00334; putative primase homolog 1856259 7680241 SPJ_1983 Streptococcus pneumoniae JJA putative primase homolog YP_002736992.1 1855699 R 488222 CDS YP_002736993.1 225855481 7679918 complement(1856259..1857032) 1 NC_012466.1 identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010; hydrolase, TatD family 1857032 7679918 SPJ_1984 Streptococcus pneumoniae JJA hydrolase, TatD family YP_002736993.1 1856259 R 488222 CDS YP_002736994.1 225855482 7679013 complement(1857337..1858230) 1 NC_012466.1 identified by match to protein family HMM PF00746; match to protein family HMM PF07564; match to protein family HMM TIGR01167; cell wall surface anchor family protein 1858230 7679013 SPJ_1985 Streptococcus pneumoniae JJA cell wall surface anchor family protein YP_002736994.1 1857337 R 488222 CDS YP_002736995.1 225855483 7679469 complement(1858514..1858648) 1 NC_012466.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 1858648 rpmH 7679469 rpmH Streptococcus pneumoniae JJA 50S ribosomal protein L34 YP_002736995.1 1858514 R 488222 CDS YP_002736996.1 225855484 7678800 complement(1858793..1860007) 1 NC_012466.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 1860007 7678800 SPJ_1987 Streptococcus pneumoniae JJA aminotransferase AlaT YP_002736996.1 1858793 R 488222 CDS YP_002736997.1 225855485 7680385 complement(1860163..1860456) 1 NC_012466.1 hypothetical protein 1860456 7680385 SPJ_1988 Streptococcus pneumoniae JJA hypothetical protein YP_002736997.1 1860163 R 488222 CDS YP_002736998.1 225855486 7679767 1860614..1861066 1 NC_012466.1 identified by match to protein family HMM PF00582; universal stress protein family 1861066 7679767 SPJ_1989 Streptococcus pneumoniae JJA universal stress protein family YP_002736998.1 1860614 D 488222 CDS YP_002736999.1 225855487 7680105 complement(1861101..1862489) 1 NC_012466.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 1862489 7680105 SPJ_1990 Streptococcus pneumoniae JJA Cof family protein YP_002736999.1 1861101 R 488222 CDS YP_002737000.1 225855488 7678413 1862555..1863517 1 NC_012466.1 identified by match to protein family HMM PF00710; L-asparaginase 1863517 7678413 SPJ_1991 Streptococcus pneumoniae JJA L-asparaginase YP_002737000.1 1862555 D 488222 CDS YP_002737001.1 225855489 7678997 complement(1863546..1863749) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1863749 7678997 SPJ_1992 Streptococcus pneumoniae JJA hypothetical protein YP_002737001.1 1863546 R 488222 CDS YP_002737002.1 225855490 7679761 complement(1863813..1864823) 1 NC_012466.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; match to protein family HMM TIGR01481; catabolite control protein A 1864823 ccpA 7679761 ccpA Streptococcus pneumoniae JJA catabolite control protein A YP_002737002.1 1863813 R 488222 CDS YP_002737003.1 225855491 7678707 complement(1865247..1865846) 1 NC_012466.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00196; response regulator 1865846 7678707 SPJ_1994 Streptococcus pneumoniae JJA response regulator YP_002737003.1 1865247 R 488222 CDS YP_002737004.1 225855492 7679343 complement(1865847..1866944) 1 NC_012466.1 identified by match to protein family HMM PF02518; match to protein family HMM PF07730; histidine kinase 1866944 7679343 SPJ_1995 Streptococcus pneumoniae JJA histidine kinase YP_002737004.1 1865847 R 488222 CDS YP_002737005.1 225855493 7679976 complement(1866944..1867681) 1 NC_012466.1 identified by match to protein family HMM PF01061; multidrug ABC transporter permease 1867681 7679976 SPJ_1996 Streptococcus pneumoniae JJA multidrug ABC transporter permease YP_002737005.1 1866944 R 488222 CDS YP_002737006.1 225855494 7680450 complement(1867683..1868567) 1 NC_012466.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1868567 7680450 SPJ_1997 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein YP_002737006.1 1867683 R 488222 CDS YP_002737007.1 225855495 7678720 complement(1868554..1868748) 1 NC_012466.1 hypothetical protein 1868748 7678720 SPJ_1998 Streptococcus pneumoniae JJA hypothetical protein YP_002737007.1 1868554 R 488222 CDS YP_002737008.1 225855496 7679327 complement(1868745..1868876) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1868876 7679327 SPJ_1999 Streptococcus pneumoniae JJA hypothetical protein YP_002737008.1 1868745 R 488222 CDS YP_002737009.1 225855497 7680588 complement(1875631..1876110) 1 NC_012466.1 competence-specific global transcription modulator 1876110 7680588 SPJ_2014 Streptococcus pneumoniae JJA competence-specific global transcription modulator YP_002737009.1 1875631 R 488222 CDS YP_002737010.1 225855498 7679978 complement(1876232..1876768) 1 NC_012466.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 1876768 nusG 7679978 nusG Streptococcus pneumoniae JJA transcription antitermination protein NusG YP_002737010.1 1876232 R 488222 CDS YP_002737011.1 225855499 7679468 complement(1876823..1876999) 1 NC_012466.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1876999 secE 7679468 secE Streptococcus pneumoniae JJA preprotein translocase subunit SecE YP_002737011.1 1876823 R 488222 CDS YP_002737012.1 225855500 7678821 complement(1877009..1877161) 1 NC_012466.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 1877161 rpmG 7678821 rpmG Streptococcus pneumoniae JJA 50S ribosomal protein L33 YP_002737012.1 1877009 R 488222 CDS YP_002737013.1 225855501 7680033 complement(1877214..1879409) 1 NC_012466.1 identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 2A 1879409 7680033 SPJ_2018 Streptococcus pneumoniae JJA penicillin-binding protein 2A YP_002737013.1 1877214 R 488222 CDS YP_002737014.1 225855502 7680129 1879535..1880371 1 NC_012466.1 identified by match to protein family HMM PF00849; ribosomal large subunit pseudouridine synthase, RluD subfamily 1880371 7680129 SPJ_2019 Streptococcus pneumoniae JJA ribosomal large subunit pseudouridine synthase, RluD subfamily YP_002737014.1 1879535 D 488222 CDS YP_002737015.1 225855503 7679727 complement(1880439..1881446) 1 NC_012466.1 identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; glyceraldehyde-3-phosphate dehydrogenase, type I 1881446 gap 7679727 gap Streptococcus pneumoniae JJA glyceraldehyde-3-phosphate dehydrogenase, type I YP_002737015.1 1880439 R 488222 CDS YP_002737016.1 225855504 7679081 complement(1881623..1882456) 1 NC_012466.1 identified by match to protein family HMM PF02687; efflux ABC transporter, permease protein 1882456 7679081 SPJ_2021 Streptococcus pneumoniae JJA efflux ABC transporter, permease protein YP_002737016.1 1881623 R 488222 CDS YP_002737017.1 225855505 7679284 complement(1883176..1883505) 1 NC_012466.1 identified by match to protein family HMM PF01710; transposase 1883505 7679284 SPJ_2022 Streptococcus pneumoniae JJA transposase YP_002737017.1 1883176 R 488222 CDS YP_002737018.1 225855506 7678677 complement(1883636..1884508) 1 NC_012466.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1884508 nadC 7678677 nadC Streptococcus pneumoniae JJA nicotinate-nucleotide pyrophosphorylase YP_002737018.1 1883636 R 488222 CDS YP_002737019.1 225855507 7679165 1884745..1886055 1 NC_012466.1 identified by match to protein family HMM PF03600; match to protein family HMM PF07158; membrane protein 1886055 7679165 SPJ_2024 Streptococcus pneumoniae JJA membrane protein YP_002737019.1 1884745 D 488222 CDS YP_002737020.1 225855508 7678523 complement(1886421..1886552) 1 NC_012466.1 hypothetical protein 1886552 7678523 SPJ_2025 Streptococcus pneumoniae JJA hypothetical protein YP_002737020.1 1886421 R 488222 CDS YP_002737021.1 225855509 7680136 complement(1887075..1887803) 1 NC_012466.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 1887803 7680136 SPJ_2026 Streptococcus pneumoniae JJA GntR family transcriptional regulator YP_002737021.1 1887075 R 488222 CDS YP_002737022.1 225855510 7679611 1887961..1889370 1 NC_012466.1 identified by match to protein family HMM PF00232; beta-glucosidase 1889370 7679611 SPJ_2027 Streptococcus pneumoniae JJA beta-glucosidase YP_002737022.1 1887961 D 488222 CDS YP_002737023.1 225855511 7679477 1889388..1890683 1 NC_012466.1 identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; phosphotransferase system system, cellobiose-specific IIC component 1890683 7679477 SPJ_2028 Streptococcus pneumoniae JJA phosphotransferase system system, cellobiose-specific IIC component YP_002737023.1 1889388 D 488222 CDS YP_002737024.1 225855512 7678851 1890649..1890996 1 NC_012466.1 identified by match to protein family HMM PF02302; cellobiose-specific phosphotransferase enzyme iib component (pts system cellobiose-specific eiib component) (eiib-cel) 1890996 7678851 SPJ_2029 Streptococcus pneumoniae JJA cellobiose-specific phosphotransferase enzyme iib component (pts system cellobiose-specific eiib component) (eiib-cel) YP_002737024.1 1890649 D 488222 CDS YP_002737025.1 225855513 7680419 1890993..1891301 1 NC_012466.1 identified by match to protein family HMM PF02255; lichenan-specific phosphotransferase enzyme iia component (pts system lichenan-specific eiia component) (eiia-lic) (eiii-lic) 1891301 7680419 SPJ_2030 Streptococcus pneumoniae JJA lichenan-specific phosphotransferase enzyme iia component (pts system lichenan-specific eiia component) (eiia-lic) (eiii-lic) YP_002737025.1 1890993 D 488222 CDS YP_002737026.1 225855514 7679856 complement(1892287..1894938) 1 NC_012466.1 identified by match to protein family HMM PF00465; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1894938 7679856 SPJ_2031 Streptococcus pneumoniae JJA bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_002737026.1 1892287 R 488222 CDS YP_002737027.1 225855515 7679458 complement(1895141..1895278) 1 NC_012466.1 hypothetical protein 1895278 7679458 SPJ_2032 Streptococcus pneumoniae JJA hypothetical protein YP_002737027.1 1895141 R 488222 CDS YP_002737028.1 225855516 7678839 complement(1895238..1895648) 1 NC_012466.1 identified by match to protein family HMM PF02493; morn motif family protein 1895648 7678839 SPJ_2033 Streptococcus pneumoniae JJA morn motif family protein YP_002737028.1 1895238 R 488222 CDS YP_002737029.1 225855517 7680305 complement(1895650..1896078) 1 NC_012466.1 identified by match to protein family HMM PF01451; phosphotyrosine protein phosphatase 1896078 7680305 SPJ_2034 Streptococcus pneumoniae JJA phosphotyrosine protein phosphatase YP_002737029.1 1895650 R 488222 CDS YP_002737030.1 225855518 7680245 complement(1896125..1896424) 1 NC_012466.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 1896424 yajC 7680245 yajC Streptococcus pneumoniae JJA preprotein translocase subunit YajC YP_002737030.1 1896125 R 488222 CDS YP_002737031.1 225855519 7679428 complement(1896541..1898517) 1 NC_012466.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1898517 tkt 7679428 tkt Streptococcus pneumoniae JJA transketolase YP_002737031.1 1896541 R 488222 CDS YP_002737032.1 225855520 7679923 complement(1898631..1899722) 1 NC_012466.1 putative L-ascorbate 6-phosphate lactonase 1899722 7679923 SPJ_2037 Streptococcus pneumoniae JJA putative L-ascorbate 6-phosphate lactonase YP_002737032.1 1898631 R 488222 CDS YP_002737033.1 225855521 7680093 complement(1899834..1901507) 1 NC_012466.1 identified by match to protein family HMM PF00874; match to protein family HMM PF08279; transcriptional regulator, BglG family 1901507 7680093 SPJ_2038 Streptococcus pneumoniae JJA transcriptional regulator, BglG family YP_002737033.1 1899834 R 488222 CDS YP_002737034.1 225855522 7678904 complement(1901686..1902390) 1 NC_012466.1 catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase 1902390 araD 7678904 araD Streptococcus pneumoniae JJA L-ribulose-5-phosphate 4-epimerase YP_002737034.1 1901686 R 488222 CDS YP_002737035.1 225855523 7679138 complement(1902392..1903255) 1 NC_012466.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase 1903255 7679138 SPJ_2040 Streptococcus pneumoniae JJA putative L-xylulose 5-phosphate 3-epimerase YP_002737035.1 1902392 R 488222 CDS YP_002737036.1 225855524 7679635 complement(1903259..1903924) 1 NC_012466.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 1903924 ulaD 7679635 ulaD Streptococcus pneumoniae JJA 3-keto-L-gulonate-6-phosphate decarboxylase YP_002737036.1 1903259 R 488222 CDS YP_002737037.1 225855525 7678738 complement(1903941..1904426) 1 NC_012466.1 identified by match to protein family HMM PF00359; ascorbate-specific phosphotransferase enzyme iia component (pts system ascorbate-specific eiia component) 1904426 7678738 SPJ_2042 Streptococcus pneumoniae JJA ascorbate-specific phosphotransferase enzyme iia component (pts system ascorbate-specific eiia component) YP_002737037.1 1903941 R 488222 CDS YP_002737038.1 225855526 7679234 complement(1904503..1904784) 1 NC_012466.1 identified by match to protein family HMM PF02302; ascorbate-specific phosphotransferase enzyme iib component (ascorbate-specific pts system eiib component) 1904784 7679234 SPJ_2043 Streptococcus pneumoniae JJA ascorbate-specific phosphotransferase enzyme iib component (ascorbate-specific pts system eiib component) YP_002737038.1 1904503 R 488222 CDS YP_002737039.1 225855527 7678457 complement(1904807..1906264) 1 NC_012466.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 1906264 7678457 SPJ_2044 Streptococcus pneumoniae JJA PTS system ascorbate-specific transporter subunit IIC YP_002737039.1 1904807 R 488222 CDS YP_002737040.1 225855528 7679035 complement(1906415..1907038) 1 NC_012466.1 hypothetical protein 1907038 7679035 SPJ_2045 Streptococcus pneumoniae JJA hypothetical protein YP_002737040.1 1906415 R 488222 CDS YP_002737041.1 225855529 7679917 complement(1907089..1908075) 1 NC_012466.1 identified by match to protein family HMM PF01424; jag protein 1908075 7679917 SPJ_2046 Streptococcus pneumoniae JJA jag protein YP_002737041.1 1907089 R 488222 CDS YP_002737042.1 225855530 7680517 complement(1908094..1908924) 1 NC_012466.1 identified by match to protein family HMM PF02096; match to protein family HMM TIGR03592; membrane protein OxaA 1 1908924 7680517 SPJ_2047 Streptococcus pneumoniae JJA membrane protein OxaA 1 YP_002737042.1 1908094 R 488222 CDS YP_002737043.1 225855531 7680298 complement(1908893..1909264) 1 NC_012466.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 1909264 rnpA 7680298 rnpA Streptococcus pneumoniae JJA ribonuclease P YP_002737043.1 1908893 R 488222 CDS YP_002737044.1 225855532 7679296 complement(1909281..1909412) 1 NC_012466.1 hypothetical protein 1909412 7679296 SPJ_2049 Streptococcus pneumoniae JJA hypothetical protein YP_002737044.1 1909281 R 488222 CDS YP_002737045.1 225855533 7679047 complement(1909413..1910603) 1 NC_012466.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 1910603 ackA 7679047 ackA Streptococcus pneumoniae JJA acetate kinase YP_002737045.1 1909413 R 488222 CDS YP_002737046.1 225855534 7679703 complement(1910654..1911607) 1 NC_012466.1 adenine-specific DNA methylase 1911607 7679703 SPJ_2051 Streptococcus pneumoniae JJA adenine-specific DNA methylase YP_002737046.1 1910654 R 488222 CDS YP_002737047.1 225855535 7680054 complement(1911668..1912255) 1 NC_012466.1 identified by match to protein family HMM PF01209; match to protein family HMM PF05175; match to protein family HMM PF08241; match to protein family HMM PF08242; methyltransferase small domain superfamily 1912255 7680054 SPJ_2052 Streptococcus pneumoniae JJA methyltransferase small domain superfamily YP_002737047.1 1911668 R 488222 CDS YP_002737048.1 225855536 7678902 complement(1912358..1912804) 1 NC_012466.1 hypothetical protein 1912804 7678902 SPJ_2053 Streptococcus pneumoniae JJA hypothetical protein YP_002737048.1 1912358 R 488222 CDS YP_002737049.1 225855537 7680001 complement(1912782..1913243) 1 NC_012466.1 competence protein ComGF 1913243 7680001 SPJ_2054 Streptococcus pneumoniae JJA competence protein ComGF YP_002737049.1 1912782 R 488222 CDS YP_002737050.1 225855538 7679189 complement(1913206..1913466) 1 NC_012466.1 hypothetical protein 1913466 7679189 SPJ_2055 Streptococcus pneumoniae JJA hypothetical protein YP_002737050.1 1913206 R 488222 CDS YP_002737051.1 225855539 7678752 complement(1913471..1913875) 1 NC_012466.1 identified by match to protein family HMM TIGR02532; competence protein CglD 1913875 7678752 SPJ_2056 Streptococcus pneumoniae JJA competence protein CglD YP_002737051.1 1913471 R 488222 CDS YP_002737052.1 225855540 7680139 complement(1913868..1914194) 1 NC_012466.1 identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532; competence protein 1914194 7680139 SPJ_2057 Streptococcus pneumoniae JJA competence protein YP_002737052.1 1913868 R 488222 CDS YP_002737053.1 225855541 7679509 complement(1914196..1915044) 1 NC_012466.1 identified by match to protein family HMM PF00482; competence protein CglB 1915044 7679509 SPJ_2058 Streptococcus pneumoniae JJA competence protein CglB YP_002737053.1 1914196 R 488222 CDS YP_002737054.1 225855542 7679131 complement(1915160..1916101) 1 NC_012466.1 identified by match to protein family HMM PF00437; putative ABC transporter subunit ComYA 1916101 7679131 SPJ_2059 Streptococcus pneumoniae JJA putative ABC transporter subunit ComYA YP_002737054.1 1915160 R 488222 CDS YP_002737055.1 225855543 7678620 complement(1916177..1916542) 1 NC_012466.1 identified by match to protein family HMM PF06279; hypothetical protein 1916542 7678620 SPJ_2060 Streptococcus pneumoniae JJA hypothetical protein YP_002737055.1 1916177 R 488222 CDS YP_002737056.1 225855544 7680047 complement(1916693..1917751) 1 NC_012466.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; alcohol dehydrogenase, zinc-containing 1917751 7680047 SPJ_2061 Streptococcus pneumoniae JJA alcohol dehydrogenase, zinc-containing YP_002737056.1 1916693 R 488222 CDS YP_002737057.1 225855545 7679563 complement(1917914..1919065) 1 NC_012466.1 identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221; N-acetylglucosamine-6-phosphate deacetylase 1919065 nagA 7679563 nagA Streptococcus pneumoniae JJA N-acetylglucosamine-6-phosphate deacetylase YP_002737057.1 1917914 R 488222 CDS YP_002737058.1 225855546 7679928 complement(1919218..1921035) 1 NC_012466.1 identified by match to protein family HMM PF01757; acyltransferase 1921035 7679928 SPJ_2063 Streptococcus pneumoniae JJA acyltransferase YP_002737058.1 1919218 R 488222 CDS YP_002737059.1 225855547 7680126 complement(1921133..1922275) 1 NC_012466.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 1922275 tgt 7680126 tgt Streptococcus pneumoniae JJA queuine tRNA-ribosyltransferase YP_002737059.1 1921133 R 488222 CDS YP_002737060.1 225855548 7679355 1922405..1923262 1 NC_012466.1 identified by match to protein family HMM PF06161; hypothetical protein 1923262 7679355 SPJ_2065 Streptococcus pneumoniae JJA hypothetical protein YP_002737060.1 1922405 D 488222 CDS YP_002737061.1 225855549 7678872 complement(1923290..1923934) 1 NC_012466.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 1923934 pcp2 7678872 pcp2 Streptococcus pneumoniae JJA pyrrolidone-carboxylate peptidase YP_002737061.1 1923290 R 488222 CDS YP_002737062.1 225855550 7679833 complement(1924041..1924400) 1 NC_012466.1 identified by match to protein family HMM PF06993; hypothetical protein 1924400 7679833 SPJ_2067 Streptococcus pneumoniae JJA hypothetical protein YP_002737062.1 1924041 R 488222 CDS YP_002737063.1 225855551 7680363 complement(1924411..1924836) 1 NC_012466.1 identified by match to protein family HMM PF01022; match to protein family HMM PF01047; transcriptional regulator, MarR family 1924836 7680363 SPJ_2068 Streptococcus pneumoniae JJA transcriptional regulator, MarR family YP_002737063.1 1924411 R 488222 CDS YP_002737064.1 225855552 7680250 complement(1925159..1926271) 1 NC_012466.1 identified by match to protein family HMM PF01476; LysM domain-containing protein 1926271 7680250 SPJ_2069 Streptococcus pneumoniae JJA LysM domain-containing protein YP_002737064.1 1925159 R 488222 CDS YP_002737065.1 225855553 7678531 complement(1926437..1927057) 1 NC_012466.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; HAD-superfamily hydrolase, subfamily IA, variant 1 1927057 7678531 SPJ_2070 Streptococcus pneumoniae JJA HAD-superfamily hydrolase, subfamily IA, variant 1 YP_002737065.1 1926437 R 488222 CDS YP_002737066.1 225855554 7679015 complement(1927061..1928341) 1 NC_012466.1 identified by match to protein family HMM PF01554; match to protein family HMM PF03023; match to protein family HMM TIGR00797; multi antimicrobial extrusion 1928341 7679015 SPJ_2071 Streptococcus pneumoniae JJA multi antimicrobial extrusion YP_002737066.1 1927061 R 488222 CDS YP_002737067.1 225855555 7679498 complement(1928402..1929886) 1 NC_012466.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1929886 thrC 7679498 thrC Streptococcus pneumoniae JJA threonine synthase YP_002737067.1 1928402 R 488222 CDS YP_002737068.1 225855556 7680386 complement(1929962..1931239) 1 NC_012466.1 hypothetical protein 1931239 7680386 SPJ_2073 Streptococcus pneumoniae JJA hypothetical protein YP_002737068.1 1929962 R 488222 CDS YP_002737069.1 225855557 7680576 complement(1937708..1938139) 1 NC_012466.1 cytidine/deoxycytidylate deaminase family protein 1938139 7680576 SPJ_2090 Streptococcus pneumoniae JJA cytidine/deoxycytidylate deaminase family protein YP_002737069.1 1937708 R 488222 CDS YP_002737070.1 225855558 7680288 complement(1938153..1939613) 1 NC_012466.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 1939613 gltX 7680288 gltX Streptococcus pneumoniae JJA glutamyl-tRNA synthetase YP_002737070.1 1938153 R 488222 CDS YP_002737071.1 225855559 7678458 complement(1939737..1941086) 1 NC_012466.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1941086 pgi 7678458 pgi Streptococcus pneumoniae JJA glucose-6-phosphate isomerase YP_002737071.1 1939737 R 488222 CDS YP_002737072.1 225855560 7678985 complement(1941073..1941252) 1 NC_012466.1 hypothetical protein 1941252 7678985 SPJ_2093 Streptococcus pneumoniae JJA hypothetical protein YP_002737072.1 1941073 R 488222 CDS YP_002737073.1 225855561 7679674 complement(1941256..1941945) 1 NC_012466.1 identified by match to protein family HMM PF00117; match to protein family HMM PF07722; glutamine amidotransferase 1941945 7679674 SPJ_2094 Streptococcus pneumoniae JJA glutamine amidotransferase YP_002737073.1 1941256 R 488222 CDS YP_002737074.1 225855562 7680074 complement(1942084..1943850) 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease 1943850 7680074 SPJ_2095 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein/permease YP_002737074.1 1942084 R 488222 CDS YP_002737075.1 225855563 7678466 1944003..1944311 1 NC_012466.1 transposase 1944311 7678466 SPJ_2096 Streptococcus pneumoniae JJA transposase YP_002737075.1 1944003 D 488222 CDS YP_002737076.1 225855564 7678805 complement(1944641..1946335) 1 NC_012466.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease 1946335 7678805 SPJ_2097 Streptococcus pneumoniae JJA ABC transporter ATP-binding protein/permease YP_002737076.1 1944641 R 488222 CDS YP_002737077.1 225855565 7679424 complement(1946482..1949016) 1 NC_012466.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 1949016 mutS 7679424 mutS Streptococcus pneumoniae JJA DNA mismatch repair protein MutS YP_002737077.1 1946482 R 488222 CDS YP_002737078.1 225855566 7679112 complement(1949067..1949513) 1 NC_012466.1 identified by match to protein family HMM PF01316; match to protein family HMM PF02863; match to protein family HMM TIGR01529; arginine repressor 1949513 argR 7679112 argR Streptococcus pneumoniae JJA arginine repressor YP_002737078.1 1949067 R 488222 CDS YP_002737079.1 225855567 7679586 1949649..1951340 1 NC_012466.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1951340 argS 7679586 argS Streptococcus pneumoniae JJA arginyl-tRNA synthetase YP_002737079.1 1949649 D 488222 CDS YP_002737080.1 225855568 7680096 complement(1951655..1952044) 1 NC_012466.1 identified by match to protein family HMM PF01609; transposase (IS4 family) 1952044 7680096 SPJ_2101 Streptococcus pneumoniae JJA transposase (IS4 family) YP_002737080.1 1951655 R 488222 CDS YP_002737081.1 225855569 7678913 1952198..1952683 1 NC_012466.1 identified by match to protein family HMM PF06172; hypothetical protein 1952683 7678913 SPJ_2102 Streptococcus pneumoniae JJA hypothetical protein YP_002737081.1 1952198 D 488222 CDS YP_002737082.1 225855570 7679401 1952767..1953474 1 NC_012466.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; alkaline phosphatase synthesis transcriptional regulatory proteinphoP 1953474 7679401 SPJ_2103 Streptococcus pneumoniae JJA alkaline phosphatase synthesis transcriptional regulatory proteinphoP YP_002737082.1 1952767 D 488222 CDS YP_002737083.1 225855571 7679877 1953475..1954806 1 NC_012466.1 identified by match to protein family HMM PF00512; match to protein family HMM PF02518; histidine kinase PnpS 1954806 7679877 SPJ_2104 Streptococcus pneumoniae JJA histidine kinase PnpS YP_002737083.1 1953475 D 488222 CDS YP_002737084.1 225855572 7680365 1954973..1955848 1 NC_012466.1 ABC transporter substrate-binding protein - phosphate transport 1955848 7680365 SPJ_2105 Streptococcus pneumoniae JJA ABC transporter substrate-binding protein - phosphate transport YP_002737084.1 1954973 D 488222 CDS YP_002737085.1 225855573 7678637 1955966..1956829 1 NC_012466.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease 1956829 pstC2 7678637 pstC2 Streptococcus pneumoniae JJA phosphate ABC transporter permease YP_002737085.1 1955966 D 488222 CDS YP_002737086.1 225855574 7679134 1956822..1957637 1 NC_012466.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease 1957637 pstA2 7679134 pstA2 Streptococcus pneumoniae JJA phosphate ABC transporter permease YP_002737086.1 1956822 D 488222 CDS YP_002737087.1 225855575 7679558 1957639..1958391 1 NC_012466.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1958391 pstB3 7679558 pstB3 Streptococcus pneumoniae JJA phosphate transporter ATP-binding protein YP_002737087.1 1957639 D 488222 CDS YP_002737088.1 225855576 7679522 1958406..1959056 1 NC_012466.1 identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU 1959056 phoU2 7679522 phoU2 Streptococcus pneumoniae JJA phosphate transport system regulatory protein PhoU YP_002737088.1 1958406 D 488222 CDS YP_002737089.1 225855577 7680181 1959124..1959540 1 NC_012466.1 transposase, IS1380-Spn1 related, truncation 1959540 7680181 SPJ_2110 Streptococcus pneumoniae JJA transposase, IS1380-Spn1 related, truncation YP_002737089.1 1959124 D 488222 CDS YP_002737090.1 225855578 7678750 complement(1959663..1960103) 1 NC_012466.1 identified by match to protein family HMM PF01381; transcriptional regulator 1960103 7678750 SPJ_2111 Streptococcus pneumoniae JJA transcriptional regulator YP_002737090.1 1959663 R 488222 CDS YP_002737091.1 225855579 7679235 1960315..1961331 1 NC_012466.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1961331 gpsA 7679235 gpsA Streptococcus pneumoniae JJA NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_002737091.1 1960315 D 488222 CDS YP_002737092.1 225855580 7678695 1961353..1962252 1 NC_012466.1 identified by match to protein family HMM PF00483; match to protein family HMM TIGR01099; UTP-glucose-1-phosphate uridylyltransferase 1962252 galU 7678695 galU Streptococcus pneumoniae JJA UTP-glucose-1-phosphate uridylyltransferase YP_002737092.1 1961353 D 488222 CDS YP_002737093.1 225855581 7679237 complement(1962324..1963001) 1 NC_012466.1 identified by match to protein family HMM PF01694; peptidase, S54 1963001 7679237 SPJ_2114 Streptococcus pneumoniae JJA peptidase, S54 YP_002737093.1 1962324 R 488222 CDS YP_002737094.1 225855582 7678976 complement(1962985..1963524) 1 NC_012466.1 identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; 5-formyltetrahydrofolate cyclo-ligase 1963524 7678976 SPJ_2115 Streptococcus pneumoniae JJA 5-formyltetrahydrofolate cyclo-ligase YP_002737094.1 1962985 R 488222 CDS YP_002737095.1 225855583 7680430 complement(1963536..1964666) 1 NC_012466.1 identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01891; peptidase, M20/M25/M40 family 1964666 7680430 SPJ_2116 Streptococcus pneumoniae JJA peptidase, M20/M25/M40 family YP_002737095.1 1963536 R 488222 CDS YP_002737096.1 225855584 7680209 complement(1964734..1965432) 1 NC_012466.1 identified by match to protein family HMM PF00132; match to protein family HMM PF08503; galactoside O-acetyltransferase 1965432 7680209 SPJ_2117 Streptococcus pneumoniae JJA galactoside O-acetyltransferase YP_002737096.1 1964734 R 488222 CDS YP_002737097.1 225855585 7678485 complement(1965662..1966573) 1 NC_012466.1 identified by match to protein family HMM PF00892; membrane protein 1966573 7678485 SPJ_2118 Streptococcus pneumoniae JJA membrane protein YP_002737097.1 1965662 R 488222 CDS YP_002737098.1 225855586 7678487 complement(1966638..1969103) 1 NC_012466.1 identified by match to protein family HMM PF00905; match to protein family HMM PF00912; penicillin-binding protein 1B 1969103 7678487 SPJ_2119 Streptococcus pneumoniae JJA penicillin-binding protein 1B YP_002737098.1 1966638 R 488222 CDS YP_002737099.1 225855587 7679393 1969245..1970501 1 NC_012466.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1970501 tyrS 7679393 tyrS Streptococcus pneumoniae JJA tyrosyl-tRNA synthetase YP_002737099.1 1969245 D 488222 CDS YP_002737100.1 225855588 7679627 complement(1970579..1972642) 1 NC_012466.1 identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01525; P-type ATPase-metal/cation transport 1972642 7679627 SPJ_2121 Streptococcus pneumoniae JJA P-type ATPase-metal/cation transport YP_002737100.1 1970579 R 488222 CDS YP_002737101.1 225855589 7680267 complement(1972644..1972922) 1 NC_012466.1 hypothetical protein 1972922 7680267 SPJ_2122 Streptococcus pneumoniae JJA hypothetical protein YP_002737101.1 1972644 R 488222 CDS YP_002737102.1 225855590 7679730 1973074..1973922 1 NC_012466.1 identified by match to protein family HMM PF08241; 23S rRNA m1G745 methyltransferase 1973922 7679730 SPJ_2123 Streptococcus pneumoniae JJA 23S rRNA m1G745 methyltransferase YP_002737102.1 1973074 D 488222 CDS YP_002737103.1 225855591 7680206 complement(1974261..1974467) 1 NC_012466.1 hypothetical protein 1974467 7680206 SPJ_2124 Streptococcus pneumoniae JJA hypothetical protein YP_002737103.1 1974261 R 488222 CDS YP_002737104.1 225855592 7678539 1974544..1975116 1 NC_012466.1 hypothetical protein 1975116 7678539 SPJ_2125 Streptococcus pneumoniae JJA hypothetical protein YP_002737104.1 1974544 D 488222 CDS YP_002737105.1 225855593 7679162 complement(1975656..1975802) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1975802 7679162 SPJ_2126 Streptococcus pneumoniae JJA hypothetical protein YP_002737105.1 1975656 R 488222 CDS YP_002737106.1 225855594 7679038 complement(1976160..1978418) 1 NC_012466.1 identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093; glycogen phosphorylase 1978418 7679038 SPJ_2127 Streptococcus pneumoniae JJA glycogen phosphorylase YP_002737106.1 1976160 R 488222 CDS YP_002737107.1 225855595 7679655 complement(1978444..1979961) 1 NC_012466.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 1979961 malQ 7679655 malQ Streptococcus pneumoniae JJA 4-alpha-glucanotransferase YP_002737107.1 1978444 R 488222 CDS YP_002737108.1 225855596 7678838 1980511..1981782 1 NC_012466.1 identified by match to protein family HMM PF01547; maltose/maltodextrin-binding protein 1981782 7678838 SPJ_2129 Streptococcus pneumoniae JJA maltose/maltodextrin-binding protein YP_002737108.1 1980511 D 488222 CDS YP_002737109.1 225855597 7678504 1981893..1983185 1 NC_012466.1 identified by match to protein family HMM PF00528; match to protein family HMM PF05154; maltodextrin transport system permease protein MalC 1983185 7678504 SPJ_2130 Streptococcus pneumoniae JJA maltodextrin transport system permease protein MalC YP_002737109.1 1981893 D 488222 CDS YP_002737110.1 225855598 7679815 1983187..1984029 1 NC_012466.1 identified by match to protein family HMM PF00528; maltose/maltodextrin ABC transporter permease 1984029 7679815 SPJ_2131 Streptococcus pneumoniae JJA maltose/maltodextrin ABC transporter permease YP_002737110.1 1983187 D 488222 CDS YP_002737111.1 225855599 7679362 1984282..1985082 1 NC_012466.1 maltodextrose utilization protein MalA 1985082 7679362 SPJ_2132 Streptococcus pneumoniae JJA maltodextrose utilization protein MalA YP_002737111.1 1984282 D 488222 CDS YP_002737112.1 225855600 7680196 1985092..1986078 1 NC_012466.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; HTH-type transcriptional regulator MalR (Maltose operontranscriptional repressor) 1986078 7680196 SPJ_2133 Streptococcus pneumoniae JJA HTH-type transcriptional regulator MalR (Maltose operontranscriptional repressor) YP_002737112.1 1985092 D 488222 CDS YP_002737113.1 225855601 7679714 1986232..1986417 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1986417 7679714 SPJ_2134 Streptococcus pneumoniae JJA hypothetical protein YP_002737113.1 1986232 D 488222 CDS YP_002737114.1 225855602 7678958 complement(1986459..1987400) 1 NC_012466.1 identified by match to protein family HMM PF02588; YitT family protein 1987400 7678958 SPJ_2135 Streptococcus pneumoniae JJA YitT family protein YP_002737114.1 1986459 R 488222 CDS YP_002737115.1 225855603 7678412 complement(1987378..1989141) 1 NC_012466.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1989141 aspS 7678412 aspS Streptococcus pneumoniae JJA aspartyl-tRNA synthetase YP_002737115.1 1987378 R 488222 CDS YP_002737116.1 225855604 7678401 complement(1989260..1989496) 1 NC_012466.1 chlorohydrolase 1989496 7678401 SPJ_2137 Streptococcus pneumoniae JJA chlorohydrolase YP_002737116.1 1989260 R 488222 CDS YP_002737117.1 225855605 7680018 complement(1989538..1989768) 1 NC_012466.1 hypothetical protein 1989768 7680018 SPJ_2138 Streptococcus pneumoniae JJA hypothetical protein YP_002737117.1 1989538 R 488222 CDS YP_002737118.1 225855606 7679954 complement(1989786..1990427) 1 NC_012466.1 identified by match to protein family HMM PF02517; caax amino protease family 1990427 7679954 SPJ_2139 Streptococcus pneumoniae JJA caax amino protease family YP_002737118.1 1989786 R 488222 CDS YP_002737119.1 225855607 7679457 complement(1990439..1991161) 1 NC_012466.1 hypothetical protein 1991161 7679457 SPJ_2140 Streptococcus pneumoniae JJA hypothetical protein YP_002737119.1 1990439 R 488222 CDS YP_002737120.1 225855608 7680082 complement(1991164..1991361) 1 NC_012466.1 hypothetical protein 1991361 7680082 SPJ_2141 Streptococcus pneumoniae JJA hypothetical protein YP_002737120.1 1991164 R 488222 CDS YP_002737121.1 225855609 7679620 complement(1991361..1991567) 1 NC_012466.1 identified by match to protein family HMM PF01381; hypothetical protein 1991567 7679620 SPJ_2142 Streptococcus pneumoniae JJA hypothetical protein YP_002737121.1 1991361 R 488222 CDS YP_002737122.1 225855610 7679575 complement(1991577..1991939) 1 NC_012466.1 hypothetical protein 1991939 7679575 SPJ_2143 Streptococcus pneumoniae JJA hypothetical protein YP_002737122.1 1991577 R 488222 CDS YP_002737123.1 225855611 7679089 complement(1992146..1993435) 1 NC_012466.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 1993435 hisS 7679089 hisS Streptococcus pneumoniae JJA histidyl-tRNA synthetase YP_002737123.1 1992146 R 488222 CDS YP_002737124.1 225855612 7678603 complement(1993513..1994760) 1 NC_012466.1 identified by match to protein family HMM PF07690; transporter, major facilitator family 1994760 7678603 SPJ_2145 Streptococcus pneumoniae JJA transporter, major facilitator family YP_002737124.1 1993513 R 488222 CDS YP_002737125.1 225855613 7680356 1994977..1996323 1 NC_012466.1 identified by match to protein family HMM PF01609; Spn1 transposase 1996323 7680356 SPJ_2146 Streptococcus pneumoniae JJA Spn1 transposase YP_002737125.1 1994977 D 488222 CDS YP_002737126.1 225855614 7679765 complement(1996659..1997420) 1 NC_012466.1 identified by match to protein family HMM TIGR01716; positive transcriptional regulator of glucosyltransferase and Spp phenotype 1997420 7679765 SPJ_2147 Streptococcus pneumoniae JJA positive transcriptional regulator of glucosyltransferase and Spp phenotype YP_002737126.1 1996659 R 488222 CDS YP_002737127.1 225855615 7679158 complement(1997485..1997619) 1 NC_012466.1 hypothetical protein 1997619 7679158 SPJ_2148 Streptococcus pneumoniae JJA hypothetical protein YP_002737127.1 1997485 R 488222 CDS YP_002737128.1 225855616 7679870 1997634..1997975 1 NC_012466.1 identified by match to protein family HMM PF01883; hypothetical protein 1997975 7679870 SPJ_2149 Streptococcus pneumoniae JJA hypothetical protein YP_002737128.1 1997634 D 488222 CDS YP_002737129.1 225855617 7679300 1998039..1998203 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 1998203 7679300 SPJ_2150 Streptococcus pneumoniae JJA hypothetical protein YP_002737129.1 1998039 D 488222 CDS YP_002737130.1 225855618 7680042 complement(1998229..1999932) 1 NC_012466.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 1999932 ilvD 7680042 ilvD Streptococcus pneumoniae JJA dihydroxy-acid dehydratase YP_002737130.1 1998229 R 488222 CDS YP_002737131.1 225855619 7679546 complement(2000165..2001097) 1 NC_012466.1 identified by match to protein family HMM PF02779; match to protein family HMM PF02780; transketolase, C- subunit 2001097 7679546 SPJ_2152 Streptococcus pneumoniae JJA transketolase, C- subunit YP_002737131.1 2000165 R 488222 CDS YP_002737132.1 225855620 7678774 complement(2001094..2001951) 1 NC_012466.1 identified by match to protein family HMM PF00456; transketolase, thiamine disphosphate-binding subunit 2001951 7678774 SPJ_2153 Streptococcus pneumoniae JJA transketolase, thiamine disphosphate-binding subunit YP_002737132.1 2001094 R 488222 CDS YP_002737133.1 225855621 7680217 complement(2001955..2003301) 1 NC_012466.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 2003301 ulaA 7680217 ulaA Streptococcus pneumoniae JJA PTS system ascorbate-specific transporter subunit IIC YP_002737133.1 2001955 R 488222 CDS YP_002737134.1 225855622 7679973 complement(2003314..2003598) 1 NC_012466.1 identified by match to protein family HMM PF02302; phosphotransferase system, galactitol-specific IIB component 2003598 7679973 SPJ_2155 Streptococcus pneumoniae JJA phosphotransferase system, galactitol-specific IIB component YP_002737134.1 2003314 R 488222 CDS YP_002737135.1 225855623 7679238 complement(2003602..2005632) 1 NC_012466.1 identified by match to protein family HMM PF00359; match to protein family HMM PF00874; transcriptional regulator, BglG family protein 2005632 7679238 SPJ_2156 Streptococcus pneumoniae JJA transcriptional regulator, BglG family protein YP_002737135.1 2003602 R 488222 CDS YP_002737136.1 225855624 7678511 2005823..2006830 1 NC_012466.1 identified by match to protein family HMM PF01145; integral membrane protein 2006830 7678511 SPJ_2157 Streptococcus pneumoniae JJA integral membrane protein YP_002737136.1 2005823 D 488222 CDS YP_002737137.1 225855625 7678919 2006833..2007033 1 NC_012466.1 hypothetical protein 2007033 7678919 SPJ_2158 Streptococcus pneumoniae JJA hypothetical protein YP_002737137.1 2006833 D 488222 CDS YP_002737138.1 225855626 7680330 2007185..2007367 1 NC_012466.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 2007367 rpmF 7680330 rpmF Streptococcus pneumoniae JJA 50S ribosomal protein L32 YP_002737138.1 2007185 D 488222 CDS YP_002737139.1 225855627 7680274 2007383..2007532 1 NC_012466.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 2007532 rpmG 7680274 rpmG Streptococcus pneumoniae JJA 50S ribosomal protein L33 YP_002737139.1 2007383 D 488222 CDS YP_002737140.1 225855628 7679711 complement(2008012..2009937) 1 NC_012466.1 identified by match to protein family HMM PF01473; choline binding protein PcpA 2009937 7679711 SPJ_2161 Streptococcus pneumoniae JJA choline binding protein PcpA YP_002737140.1 2008012 R 488222 CDS YP_002737141.1 225855629 7678766 2010272..2010454 1 NC_012466.1 transposase 2010454 7678766 SPJ_2162 Streptococcus pneumoniae JJA transposase YP_002737141.1 2010272 D 488222 CDS YP_002737142.1 225855630 7680123 2010411..2010842 1 NC_012466.1 mobile genetic element 2010842 7680123 SPJ_2163 Streptococcus pneumoniae JJA mobile genetic element YP_002737142.1 2010411 D 488222 CDS YP_002737143.1 225855631 7679368 2010847..2011110 1 NC_012466.1 mobile genetic element 2011110 7679368 SPJ_2164 Streptococcus pneumoniae JJA mobile genetic element YP_002737143.1 2010847 D 488222 CDS YP_002737144.1 225855632 7679188 complement(2011180..2011455) 1 NC_012466.1 hypothetical protein 2011455 7679188 SPJ_2165 Streptococcus pneumoniae JJA hypothetical protein YP_002737144.1 2011180 R 488222 CDS YP_002737145.1 225855633 7678425 complement(2011521..2011652) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 2011652 7678425 SPJ_2166 Streptococcus pneumoniae JJA hypothetical protein YP_002737145.1 2011521 R 488222 CDS YP_002737146.1 225855634 7680404 complement(2011832..2013712) 1 NC_012466.1 identified by match to protein family HMM PF00728; N-acetyl-beta-D-glucosaminidase 2013712 7680404 SPJ_2167 Streptococcus pneumoniae JJA N-acetyl-beta-D-glucosaminidase YP_002737146.1 2011832 R 488222 CDS YP_002737147.1 225855635 7679676 complement(2013706..2014587) 1 NC_012466.1 identified by match to protein family HMM PF00480; ROK family protein 2014587 7679676 SPJ_2168 Streptococcus pneumoniae JJA ROK family protein YP_002737147.1 2013706 R 488222 CDS YP_002737148.1 225855636 7680101 complement(2014659..2017304) 1 NC_012466.1 identified by match to protein family HMM PF01074; match to protein family HMM PF07748; glycosyl hydrolase, family 38 2017304 7680101 SPJ_2169 Streptococcus pneumoniae JJA glycosyl hydrolase, family 38 YP_002737148.1 2014659 R 488222 CDS YP_002737149.1 225855637 7678972 complement(2017395..2018675) 1 NC_012466.1 identified by match to protein family HMM PF06824; hypothetical protein 2018675 7678972 SPJ_2170 Streptococcus pneumoniae JJA hypothetical protein YP_002737149.1 2017395 R 488222 CDS YP_002737150.1 225855638 7678499 2018846..2020930 1 NC_012466.1 identified by match to protein family HMM PF07971; match to protein family HMM TIGR01180; antigen, cell wall surface anchor family 2020930 7678499 SPJ_2171 Streptococcus pneumoniae JJA antigen, cell wall surface anchor family YP_002737150.1 2018846 D 488222 CDS YP_002737151.1 225855639 7680203 complement(2020970..2022649) 1 NC_012466.1 FucA 2022649 7680203 SPJ_2172 Streptococcus pneumoniae JJA FucA YP_002737151.1 2020970 R 488222 CDS YP_002737152.1 225855640 7679724 2023405..2024634 1 NC_012466.1 catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 2024634 arcA 7679724 arcA Streptococcus pneumoniae JJA arginine deiminase YP_002737152.1 2023405 D 488222 CDS YP_002737153.1 225855641 7679836 2024692..2025708 1 NC_012466.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 2025708 argF 7679836 argF Streptococcus pneumoniae JJA ornithine carbamoyltransferase YP_002737153.1 2024692 D 488222 CDS YP_002737154.1 225855642 7680170 2025873..2026820 1 NC_012466.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 2026820 arcC 7680170 arcC Streptococcus pneumoniae JJA carbamate kinase YP_002737154.1 2025873 D 488222 CDS YP_002737155.1 225855643 7678595 2027031..2028542 1 NC_012466.1 identified by match to protein family HMM PF03606; arginine-ornithine antiporter 2028542 7678595 SPJ_2176 Streptococcus pneumoniae JJA arginine-ornithine antiporter YP_002737155.1 2027031 D 488222 CDS YP_002737156.1 225855644 7678945 2028564..2029895 1 NC_012466.1 identified by match to protein family HMM PF01546; match to protein family HMM TIGR01887; hypothetical protein 2029895 7678945 SPJ_2177 Streptococcus pneumoniae JJA hypothetical protein YP_002737156.1 2028564 D 488222 CDS YP_002737157.1 225855645 7679040 2029989..2030117 1 NC_012466.1 transposase 2030117 7679040 SPJ_2178 Streptococcus pneumoniae JJA transposase YP_002737157.1 2029989 D 488222 CDS YP_002737158.1 225855646 7679371 complement(2030300..2030590) 1 NC_012466.1 hypothetical protein 2030590 7679371 SPJ_2179 Streptococcus pneumoniae JJA hypothetical protein YP_002737158.1 2030300 R 488222 CDS YP_002737159.1 225855647 7679294 complement(2030578..2030829) 1 NC_012466.1 identified by match to protein family HMM PF04650; match to protein family HMM TIGR01168; gram-positive signal peptide, ysirk family protein 2030829 7679294 SPJ_2180 Streptococcus pneumoniae JJA gram-positive signal peptide, ysirk family protein YP_002737159.1 2030578 R 488222 CDS YP_002737160.1 225855648 7678757 2031033..2031191 1 NC_012466.1 chlorohydrolase 2031191 7678757 SPJ_2181 Streptococcus pneumoniae JJA chlorohydrolase YP_002737160.1 2031033 D 488222 CDS YP_002737161.1 225855649 7679704 complement(2031228..2032127) 1 NC_012466.1 identified by match to protein family HMM PF01145; spfh domain/band 7 family 2032127 7679704 SPJ_2182 Streptococcus pneumoniae JJA spfh domain/band 7 family YP_002737161.1 2031228 R 488222 CDS YP_002737162.1 225855650 7679091 complement(2032257..2033408) 1 NC_012466.1 identified by match to protein family HMM PF00465; alcohol dehydrogenase, iron-containing 2033408 7679091 SPJ_2183 Streptococcus pneumoniae JJA alcohol dehydrogenase, iron-containing YP_002737162.1 2032257 R 488222 CDS YP_002737163.1 225855651 7678999 complement(2033554..2035320) 1 NC_012466.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 2035320 fucI 7678999 fucI Streptococcus pneumoniae JJA L-fucose isomerase YP_002737163.1 2033554 R 488222 CDS YP_002737164.1 225855652 7678534 complement(2035377..2038493) 1 NC_012466.1 identified by match to protein family HMM PF00754; match to protein family HMM PF08306; match to protein family HMM PF08307; glycosyl hydrolase family 98 2038493 7678534 SPJ_2185 Streptococcus pneumoniae JJA glycosyl hydrolase family 98 YP_002737164.1 2035377 R 488222 CDS YP_002737165.1 225855653 7680489 complement(2038503..2040797) 1 NC_012466.1 large secreted protein 2040797 7680489 SPJ_2186 Streptococcus pneumoniae JJA large secreted protein YP_002737165.1 2038503 R 488222 CDS YP_002737166.1 225855654 7679487 complement(2040856..2041656) 1 NC_012466.1 identified by match to protein family HMM PF03613; mannose permease iid component (pts system mannose-specific eiidcomponent) (eiid-man) (eii-m-man) 2041656 7679487 SPJ_2187 Streptococcus pneumoniae JJA mannose permease iid component (pts system mannose-specific eiidcomponent) (eiid-man) (eii-m-man) YP_002737166.1 2040856 R 488222 CDS YP_002737167.1 225855655 7679906 complement(2041653..2042426) 1 NC_012466.1 identified by match to protein family HMM PF03609; phosphotransferase system sugar-specific EII component 2042426 7679906 SPJ_2188 Streptococcus pneumoniae JJA phosphotransferase system sugar-specific EII component YP_002737167.1 2041653 R 488222 CDS YP_002737168.1 225855656 7680396 complement(2042451..2042921) 1 NC_012466.1 identified by match to protein family HMM PF03830; PTS system, IIB component 2042921 7680396 SPJ_2189 Streptococcus pneumoniae JJA PTS system, IIB component YP_002737168.1 2042451 R 488222 CDS YP_002737169.1 225855657 7680040 complement(2042912..2043355) 1 NC_012466.1 identified by match to protein family HMM PF03610; PTS system, IIA component 2043355 7680040 SPJ_2190 Streptococcus pneumoniae JJA PTS system, IIA component YP_002737169.1 2042912 R 488222 CDS YP_002737170.1 225855658 7679417 complement(2043336..2043776) 1 NC_012466.1 identified by match to protein family HMM PF05025; fucose operon FucU protein 2043776 7679417 SPJ_2191 Streptococcus pneumoniae JJA fucose operon FucU protein YP_002737170.1 2043336 R 488222 CDS YP_002737171.1 225855659 7679098 complement(2043788..2044426) 1 NC_012466.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 2044426 7679098 SPJ_2192 Streptococcus pneumoniae JJA L-fuculose phosphate aldolase YP_002737171.1 2043788 R 488222 CDS YP_002737172.1 225855660 7678621 complement(2044541..2045944) 1 NC_012466.1 identified by match to protein family HMM PF00370; match to protein family HMM PF02782; rhamnulokinase (Rhamnulose kinase) 2045944 7678621 SPJ_2193 Streptococcus pneumoniae JJA rhamnulokinase (Rhamnulose kinase) YP_002737172.1 2044541 R 488222 CDS YP_002737173.1 225855661 7680370 2046120..2046893 1 NC_012466.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; regulator of fucose operon 2046893 7680370 SPJ_2194 Streptococcus pneumoniae JJA regulator of fucose operon YP_002737173.1 2046120 D 488222 CDS YP_002737174.1 225855662 7679900 complement(2048064..2049569) 1 NC_012466.1 identified by match to protein family HMM PF01297; match to protein family HMM PF09223; zinc-binding lipoprotein AdcA 2049569 7679900 SPJ_2195 Streptococcus pneumoniae JJA zinc-binding lipoprotein AdcA YP_002737174.1 2048064 R 488222 CDS YP_002737175.1 225855663 7679578 complement(2049579..2050385) 1 NC_012466.1 identified by match to protein family HMM PF00950; zinc ABC transporter permease 2050385 7679578 SPJ_2196 Streptococcus pneumoniae JJA zinc ABC transporter permease YP_002737175.1 2049579 R 488222 CDS YP_002737176.1 225855664 7678798 complement(2050378..2051082) 1 NC_012466.1 identified by match to protein family HMM PF00005; zinc transport system ATP-binding protein AdcC 2051082 7678798 SPJ_2197 Streptococcus pneumoniae JJA zinc transport system ATP-binding protein AdcC YP_002737176.1 2050378 R 488222 CDS YP_002737177.1 225855665 7678645 complement(2051082..2051522) 1 NC_012466.1 identified by match to protein family HMM PF01022; match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF01978; match to protein family HMM PF08279; putative transcriptional repressor 2051522 7678645 SPJ_2198 Streptococcus pneumoniae JJA putative transcriptional repressor YP_002737177.1 2051082 R 488222 CDS YP_002737178.1 225855666 7678448 2051507..2051644 1 NC_012466.1 hypothetical protein 2051644 7678448 SPJ_2199 Streptococcus pneumoniae JJA hypothetical protein YP_002737178.1 2051507 D 488222 CDS YP_002737179.1 225855667 7680150 complement(2051677..2052945) 1 NC_012466.1 identified by match to protein family HMM PF04914; match to protein family HMM PF04915; match to protein family HMM PF04918; D-alanine transfer from undecaprenol-phosphate to the poly 2052945 7680150 SPJ_2200 Streptococcus pneumoniae JJA D-alanine transfer from undecaprenol-phosphate to the poly YP_002737179.1 2051677 R 488222 CDS YP_002737180.1 225855668 7679957 complement(2053029..2053166) 1 NC_012466.1 undecaprenol-phosphate-poly 2053166 7679957 SPJ_2201 Streptococcus pneumoniae JJA undecaprenol-phosphate-poly YP_002737180.1 2053029 R 488222 CDS YP_002737181.1 225855669 7679479 complement(2053159..2053398) 1 NC_012466.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 2053398 dltC 7679479 dltC Streptococcus pneumoniae JJA D-alanine--poly(phosphoribitol) ligase subunit 2 YP_002737181.1 2053159 R 488222 CDS YP_002737182.1 225855670 7678713 complement(2053412..2054656) 1 NC_012466.1 identified by match to protein family HMM PF03062; protein DltB 2054656 7678713 SPJ_2203 Streptococcus pneumoniae JJA protein DltB YP_002737182.1 2053412 R 488222 CDS YP_002737183.1 225855671 7679615 complement(2054653..2056203) 1 NC_012466.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 2056203 dltA 7679615 dltA Streptococcus pneumoniae JJA D-alanine--poly(phosphoribitol) ligase subunit 1 YP_002737183.1 2054653 R 488222 CDS YP_002737184.1 225855672 7678849 complement(2056224..2056355) 1 NC_012466.1 hypothetical protein 2056355 7678849 SPJ_2205 Streptococcus pneumoniae JJA hypothetical protein YP_002737184.1 2056224 R 488222 CDS YP_002737185.1 225855673 7678398 complement(2056669..2057574) 1 NC_012466.1 permease of the major facilitator superfamily 2057574 7678398 SPJ_2206 Streptococcus pneumoniae JJA permease of the major facilitator superfamily YP_002737185.1 2056669 R 488222 CDS YP_002737186.1 225855674 7680103 complement(2058303..2059580) 1 NC_012466.1 identified by match to protein family HMM PF00078; match to protein family HMM PF08388; GBSi1, group II intron, maturase 2059580 7680103 SPJ_2207 Streptococcus pneumoniae JJA GBSi1, group II intron, maturase YP_002737186.1 2058303 R 488222 CDS YP_002737187.1 225855675 7679869 2060663..2061322 1 NC_012466.1 hypothetical protein 2061322 7679869 SPJ_2208 Streptococcus pneumoniae JJA hypothetical protein YP_002737187.1 2060663 D 488222 CDS YP_002737188.1 225855676 7679049 complement(2061409..2061555) 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 2061555 7679049 SPJ_2209 Streptococcus pneumoniae JJA hypothetical protein YP_002737188.1 2061409 R 488222 CDS YP_002737189.1 225855677 7679981 2061714..2061830 1 NC_012466.1 identified by Glimmer3; putative; hypothetical protein 2061830 7679981 SPJ_2210 Streptococcus pneumoniae JJA hypothetical protein YP_002737189.1 2061714 D 488222 CDS YP_002737190.1 225855678 7680468 complement(2061909..2062613) 1 NC_012466.1 identified by match to protein family HMM PF00230; match to protein family HMM TIGR00861; glycerol uptake facilitator protein 2062613 7680468 SPJ_2211 Streptococcus pneumoniae JJA glycerol uptake facilitator protein YP_002737190.1 2061909 R 488222 CDS YP_002737191.1 225855679 7678781 complement(2062683..2064509) 1 NC_012466.1 identified by match to protein family HMM PF01266; alpha-glycerophosphate oxidase (Glycerol-3-phosphateoxidase) (Exported protein 6) 2064509 7678781 SPJ_2212 Streptococcus pneumoniae JJA alpha-glycerophosphate oxidase (Glycerol-3-phosphateoxidase) (Exported protein 6) YP_002737191.1 2062683 R 488222 CDS YP_002737192.1 225855680 7679293 complement(2064551..2066059) 1 NC_012466.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 2066059 glpK 7679293 glpK Streptococcus pneumoniae JJA glycerol kinase YP_002737192.1 2064551 R 488222 CDS YP_002737193.1 225855681 7678771 complement(2066218..2067627) 1 NC_012466.1 identified by match to protein family HMM PF05043; M protein trans-acting positive regulator (MGA) 2067627 7678771 SPJ_2214 Streptococcus pneumoniae JJA M protein trans-acting positive regulator (MGA) YP_002737193.1 2066218 R 488222 CDS YP_002737194.1 225855682 7680480 2067810..2068682 1 NC_012466.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 2068682 hslO 7680480 hslO Streptococcus pneumoniae JJA Hsp33-like chaperonin YP_002737194.1 2067810 D 488222 CDS YP_002737195.1 225855683 7678897 2068669..2069649 1 NC_012466.1 identified by match to protein family HMM PF00724; match to protein family HMM PF01180; match to protein family HMM PF01207; match to protein family HMM TIGR00737; tRNA-dihydrouridine synthase B 2069649 7678897 SPJ_2216 Streptococcus pneumoniae JJA tRNA-dihydrouridine synthase B YP_002737195.1 2068669 D 488222 CDS YP_002737196.1 225855684 7678988 complement(2069879..2071678) 1 NC_012466.1 identified by match to protein family HMM PF01473; surface protein PspC 2071678 7678988 SPJ_2217 Streptococcus pneumoniae JJA surface protein PspC YP_002737196.1 2069879 R 488222 CDS YP_002737197.1 225855685 7679608 complement(2072057..2072584) 1 NC_012466.1 identified by match to protein family HMM PF04140; hypothetical protein 2072584 7679608 SPJ_2218 Streptococcus pneumoniae JJA hypothetical protein YP_002737197.1 2072057 R 488222 CDS YP_002737198.1 225855686 7679964 complement(2072667..2074007) 1 NC_012466.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; histidine kinase 2074007 7679964 SPJ_2219 Streptococcus pneumoniae JJA histidine kinase YP_002737198.1 2072667 R 488222 CDS YP_002737199.1 225855687 7679489 complement(2074004..2074657) 1 NC_012466.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator 2074657 7679489 SPJ_2220 Streptococcus pneumoniae JJA DNA-binding response regulator YP_002737199.1 2074004 R 488222 CDS YP_002737200.1 225855688 7680122 complement(2074978..2077410) 1 NC_012466.1 identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; chaperone ClpB 1 2077410 7680122 SPJ_2221 Streptococcus pneumoniae JJA chaperone ClpB 1 YP_002737200.1 2074978 R 488222 CDS YP_002737201.1 225855689 7679317 complement(2077412..2077870) 1 NC_012466.1 identified by match to protein family HMM PF05848; transcriptional regulator CtsR 2077870 7679317 SPJ_2222 Streptococcus pneumoniae JJA transcriptional regulator CtsR YP_002737201.1 2077412 R 488222 CDS YP_002737202.1 225855690 7679121 complement(2077989..2078717) 1 NC_012466.1 identified by match to protein family HMM PF00005; anion ABC transporter ATP-binding protein 2078717 7679121 SPJ_2223 Streptococcus pneumoniae JJA anion ABC transporter ATP-binding protein YP_002737202.1 2077989 R 488222 CDS YP_002737203.1 225855691 7678765 complement(2078717..2079724) 1 NC_012466.1 identified by match to protein family HMM PF09084; ABC transporter substrate-binding protein 2079724 7678765 SPJ_2224 Streptococcus pneumoniae JJA ABC transporter substrate-binding protein YP_002737203.1 2078717 R 488222 CDS YP_002737204.1 225855692 7679247 complement(2079762..2080523) 1 NC_012466.1 identified by match to protein family HMM PF00528; ABC transporter permease 2080523 7679247 SPJ_2225 Streptococcus pneumoniae JJA ABC transporter permease YP_002737204.1 2079762 R 488222 CDS YP_002737205.1 225855693 7679912 complement(2080483..2080773) 1 NC_012466.1 hypothetical protein 2080773 7679912 SPJ_2226 Streptococcus pneumoniae JJA hypothetical protein YP_002737205.1 2080483 R 488222 CDS YP_002737206.1 225855694 7680229 complement(2081029..2082147) 1 NC_012466.1 identified by match to protein family HMM PF01473; match to protein family HMM PF05257; match to protein family HMM PF08460; choline binding protein D 2082147 7680229 SPJ_2227 Streptococcus pneumoniae JJA choline binding protein D YP_002737206.1 2081029 R 488222 CDS YP_002737207.1 225855695 7680264 complement(2082236..2082502) 1 NC_012466.1 identified by match to protein family HMM PF06257; hypothetical protein 2082502 7680264 SPJ_2228 Streptococcus pneumoniae JJA hypothetical protein YP_002737207.1 2082236 R 488222 CDS YP_002737208.1 225855696 7678436 complement(2082504..2083856) 1 NC_012466.1 unwinds double stranded DNA; replicative DNA helicase 2083856 dnaB 7678436 dnaB Streptococcus pneumoniae JJA replicative DNA helicase YP_002737208.1 2082504 R 488222 CDS YP_002737209.1 225855697 7678672 complement(2083900..2084352) 1 NC_012466.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 2084352 rplI 7678672 rplI Streptococcus pneumoniae JJA 50S ribosomal protein L9 YP_002737209.1 2083900 R 488222 CDS YP_002737210.1 225855698 7679407 complement(2084349..2086322) 1 NC_012466.1 identified by match to protein family HMM PF01368; match to protein family HMM PF02272; DHH subfamily 1 protein 2086322 7679407 SPJ_2231 Streptococcus pneumoniae JJA DHH subfamily 1 protein YP_002737210.1 2084349 R 488222 CDS YP_002737211.1 225855699 7679658 complement(2086458..2087006) 1 NC_012466.1 identified by match to protein family HMM PF02482; match to protein family HMM TIGR00741; ribosome-associated protein Y 2087006 7679658 SPJ_2232 Streptococcus pneumoniae JJA ribosome-associated protein Y YP_002737211.1 2086458 R 488222 CDS YP_002737212.1 225855700 7680344 complement(2087086..2087748) 1 NC_012466.1 putative competence protein ComF 2087748 7680344 SPJ_2233 Streptococcus pneumoniae JJA putative competence protein ComF YP_002737212.1 2087086 R 488222 CDS YP_002737213.1 225855701 7679647 complement(2087745..2089043) 1 NC_012466.1 identified by match to protein family HMM PF00271; match to protein family HMM PF04851; superfamily II ATP-dependent DNA/RNA helicase required for DNA uptake 2089043 7679647 SPJ_2234 Streptococcus pneumoniae JJA superfamily II ATP-dependent DNA/RNA helicase required for DNA uptake YP_002737213.1 2087745 R 488222 CDS YP_002737214.1 225855702 7680239 2089099..2089734 1 NC_012466.1 identified by match to protein family HMM PF01205; match to protein family HMM PF09186; match to protein family HMM TIGR00257; hypothetical protein 2089734 7680239 SPJ_2235 Streptococcus pneumoniae JJA hypothetical protein YP_002737214.1 2089099 D 488222 CDS YP_002737215.1 225855703 7678404 2090019..2090939 1 NC_012466.1 identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; cysteine synthase A 2090939 cysK 7678404 cysK Streptococcus pneumoniae JJA cysteine synthase A YP_002737215.1 2090019 D 488222 CDS YP_002737216.1 225855704 7678996 complement(2091136..2091534) 1 NC_012466.1 identified by match to protein family HMM PF03050; transposase 2091534 7678996 SPJ_2237 Streptococcus pneumoniae JJA transposase YP_002737216.1 2091136 R 488222 CDS YP_002737217.1 225855705 7679285 2091654..2091812 1 NC_012466.1 transposase family protein 2091812 7679285 SPJ_2238 Streptococcus pneumoniae JJA transposase family protein YP_002737217.1 2091654 D 488222 CDS YP_002737218.1 225855706 7680373 complement(2091967..2092182) 1 NC_012466.1 identified by match to protein family HMM PF05717; IS66 family element, Orf2 2092182 7680373 SPJ_2239 Streptococcus pneumoniae JJA IS66 family element, Orf2 YP_002737218.1 2091967 R 488222 CDS YP_002737219.1 225855707 7678432 complement(2092536..2093576) 1 NC_012466.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 2093576 tsf 7678432 tsf Streptococcus pneumoniae JJA elongation factor Ts YP_002737219.1 2092536 R 488222 CDS YP_002737220.1 225855708 7678790 complement(2093655..2094434) 1 NC_012466.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 2094434 rpsB 7678790 rpsB Streptococcus pneumoniae JJA 30S ribosomal protein S2 YP_002737220.1 2093655 R 488222 CDS YP_002737221.1 225855709 7679675 complement(2094658..2095836) 1 NC_012466.1 identified by match to protein family HMM PF05257; general stress protein GSP-781 2095836 7679675 SPJ_2242 Streptococcus pneumoniae JJA general stress protein GSP-781 YP_002737221.1 2094658 R 488222 CDS YP_002737222.1 225855710 7680290 complement(2095930..2096424) 1 NC_012466.1 identified by match to protein family HMM PF04093; match to protein family HMM TIGR03426; rod shape-determining protein MreD 2096424 mreD 7680290 mreD Streptococcus pneumoniae JJA rod shape-determining protein MreD YP_002737222.1 2095930 R 488222 CDS YP_002737223.1 225855711 7678959 complement(2096424..2097242) 1 NC_012466.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 2097242 mreC 7678959 mreC Streptococcus pneumoniae JJA rod shape-determining protein MreC YP_002737223.1 2096424 R 488222 CDS YP_002737224.1 225855712 7679745 complement(2097301..2098095) 1 NC_012466.1 identified by match to protein family HMM PF02361; ABC transporter permease 2098095 7679745 SPJ_2245 Streptococcus pneumoniae JJA ABC transporter permease YP_002737224.1 2097301 R 488222 CDS YP_002737225.1 225855713 7680456 complement(2098088..2098927) 1 NC_012466.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 2098927 cbiO 7680456 cbiO Streptococcus pneumoniae JJA cobalt transporter ATP-binding subunit YP_002737225.1 2098088 R 488222 CDS YP_002737226.1 225855714 7678490 complement(2098912..2099739) 1 NC_012466.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 2099739 cbiO 7678490 cbiO Streptococcus pneumoniae JJA cobalt transporter ATP-binding subunit YP_002737226.1 2098912 R 488222 CDS YP_002737227.1 225855715 7678925 complement(2099736..2100281) 1 NC_012466.1 identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 2100281 pgsA 7678925 pgsA Streptococcus pneumoniae JJA CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_002737227.1 2099736 R 488222 CDS YP_002737228.1 225855716 7680429 complement(2100292..2101113) 1 NC_012466.1 hypothetical protein 2101113 7680429 SPJ_2249 Streptococcus pneumoniae JJA hypothetical protein YP_002737228.1 2100292 R 488222 CDS YP_002737229.1 225855717 7680458 complement(2101155..2102438) 1 NC_012466.1 identified by match to protein family HMM PF00675; match to protein family HMM PF05193; peptidase, M16 family 2102438 7680458 SPJ_2250 Streptococcus pneumoniae JJA peptidase, M16 family YP_002737229.1 2101155 R 488222 CDS YP_002737230.1 225855718 7679230 complement(2102435..2103685) 1 NC_012466.1 identified by match to protein family HMM PF05193; peptidase, M16 family 2103685 7679230 SPJ_2251 Streptococcus pneumoniae JJA peptidase, M16 family YP_002737230.1 2102435 R 488222 CDS YP_002737231.1 225855719 7678613 2103844..2104212 1 NC_012466.1 identified by match to protein family HMM TIGR02988; S4 domain protein YaaA, putative 2104212 7678613 SPJ_2252 Streptococcus pneumoniae JJA S4 domain protein YaaA, putative YP_002737231.1 2103844 D 488222 CDS YP_002737232.1 225855720 7680177 2104215..2105312 1 NC_012466.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2105312 recF 7680177 recF Streptococcus pneumoniae JJA recombination protein F YP_002737232.1 2104215 D 488222 CDS YP_002737233.1 225855721 7680412 complement(2105363..2106841) 1 NC_012466.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2106841 guaB 7680412 guaB Streptococcus pneumoniae JJA inosine 5'-monophosphate dehydrogenase YP_002737233.1 2105363 R 488222 CDS YP_002737234.1 225855722 7678554 complement(2106993..2108018) 1 NC_012466.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II 2108018 trpS 7678554 trpS Streptococcus pneumoniae JJA tryptophanyl-tRNA synthetase II YP_002737234.1 2106993 R 488222 CDS YP_002737235.1 225855723 7679181 2108224..2109846 1 NC_012466.1 identified by match to protein family HMM PF00005; ATPase component of ABC transporters with duplicated ATPase domains 2109846 7679181 SPJ_2256 Streptococcus pneumoniae JJA ATPase component of ABC transporters with duplicated ATPase domains YP_002737235.1 2108224 D 488222 CDS YP_002737236.1 225855724 7679506 2109908..2112460 1 NC_012466.1 ABC transporter permease 2112460 7679506 SPJ_2257 Streptococcus pneumoniae JJA ABC transporter permease YP_002737236.1 2109908 D 488222 CDS YP_002737237.1 225855725 7679491 complement(2112561..2112875) 1 NC_012466.1 phage infection protein 2112875 7679491 SPJ_2258 Streptococcus pneumoniae JJA phage infection protein YP_002737237.1 2112561 R 488222 CDS YP_002737238.1 225855726 7679669 complement(2112903..2113241) 1 NC_012466.1 phage infection protein 2113241 7679669 SPJ_2259 Streptococcus pneumoniae JJA phage infection protein YP_002737238.1 2112903 R 488222 CDS YP_002737239.1 225855727 7679806 complement(2113326..2114093) 1 NC_012466.1 hypothetical protein 2114093 7679806 SPJ_2260 Streptococcus pneumoniae JJA hypothetical protein YP_002737239.1 2113326 R 488222 CDS YP_002737240.1 225855728 7679440 2114272..2114814 1 NC_012466.1 identified by match to protein family HMM PF00440; TetR family transcriptional regulator 2114814 7679440 SPJ_2261 Streptococcus pneumoniae JJA TetR family transcriptional regulator YP_002737240.1 2114272 D 488222 CDS YP_002737241.1 225855729 7680605 complement(2115057..2115809) 1 NC_012466.1 identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator 2115809 7680605 SPJ_2264 Streptococcus pneumoniae JJA response regulator YP_002737241.1 2115057 R 488222 CDS YP_002737242.1 225855730 7680169 complement(2115806..2117131) 1 NC_012466.1 identified by match to protein family HMM PF02518; ComD 2117131 7680169 SPJ_2265 Streptococcus pneumoniae JJA ComD YP_002737242.1 2115806 R 488222 CDS YP_002737243.1 225855731 7678538 complement(2117152..2117277) 1 NC_012466.1 identified by match to protein family HMM PF03047; hypothetical protein 2117277 7678538 SPJ_2266 Streptococcus pneumoniae JJA hypothetical protein YP_002737243.1 2117152 R 488222 CDS YP_002737244.1 225855732 7680562 complement(2117559..2118038) 1 NC_012466.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 2118038 7680562 SPJ_2268 Streptococcus pneumoniae JJA rRNA large subunit methyltransferase YP_002737244.1 2117559 R 488222 CDS YP_002737245.1 225855733 7680335 2118221..2119402 1 NC_012466.1 identified by match to protein family HMM PF00089; trypsin domain protein 2119402 7680335 SPJ_2269 Streptococcus pneumoniae JJA trypsin domain protein YP_002737245.1 2118221 D 488222 CDS YP_002737246.1 225855734 7680023 2119460..2120218 1 NC_012466.1 identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; stage 0 sporulation protein J 2120218 7680023 SPJ_2270 Streptococcus pneumoniae JJA stage 0 sporulation protein J YP_002737246.1 2119460 D 488222 CDS