-- dump date 20140620_084832 -- class Genbank::misc_feature -- table misc_feature_note -- id note 869215000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 869215000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215000003 Walker A motif; other site 869215000004 ATP binding site [chemical binding]; other site 869215000005 Walker B motif; other site 869215000006 arginine finger; other site 869215000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 869215000008 DnaA box-binding interface [nucleotide binding]; other site 869215000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 869215000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 869215000011 putative DNA binding surface [nucleotide binding]; other site 869215000012 dimer interface [polypeptide binding]; other site 869215000013 beta-clamp/clamp loader binding surface; other site 869215000014 beta-clamp/translesion DNA polymerase binding surface; other site 869215000015 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 869215000016 GTP-binding protein YchF; Reviewed; Region: PRK09601 869215000017 YchF GTPase; Region: YchF; cd01900 869215000018 G1 box; other site 869215000019 GTP/Mg2+ binding site [chemical binding]; other site 869215000020 Switch I region; other site 869215000021 G2 box; other site 869215000022 Switch II region; other site 869215000023 G3 box; other site 869215000024 G4 box; other site 869215000025 G5 box; other site 869215000026 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 869215000027 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 869215000028 putative active site [active] 869215000029 catalytic residue [active] 869215000030 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 869215000031 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 869215000032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869215000033 ATP binding site [chemical binding]; other site 869215000034 putative Mg++ binding site [ion binding]; other site 869215000035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869215000036 nucleotide binding region [chemical binding]; other site 869215000037 ATP-binding site [chemical binding]; other site 869215000038 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 869215000039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869215000040 RNA binding surface [nucleotide binding]; other site 869215000041 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 869215000042 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 869215000043 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 869215000044 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 869215000045 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 869215000046 Ligand Binding Site [chemical binding]; other site 869215000047 TilS substrate C-terminal domain; Region: TilS_C; smart00977 869215000048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869215000049 active site 869215000050 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 869215000051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215000052 Walker A motif; other site 869215000053 ATP binding site [chemical binding]; other site 869215000054 Walker B motif; other site 869215000055 arginine finger; other site 869215000056 Peptidase family M41; Region: Peptidase_M41; pfam01434 869215000057 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 869215000059 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 869215000060 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 869215000061 GDP-binding site [chemical binding]; other site 869215000062 ACT binding site; other site 869215000063 IMP binding site; other site 869215000064 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 869215000065 active site 869215000066 catalytic residues [active] 869215000067 DNA binding site [nucleotide binding] 869215000068 Int/Topo IB signature motif; other site 869215000069 DNA polymerase III subunit epsilon; Validated; Region: PRK06195 869215000070 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 869215000071 active site 869215000072 catalytic site [active] 869215000073 substrate binding site [chemical binding]; other site 869215000074 Domain of unknown function (DUF955); Region: DUF955; pfam06114 869215000075 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869215000076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215000077 non-specific DNA binding site [nucleotide binding]; other site 869215000078 salt bridge; other site 869215000079 sequence-specific DNA binding site [nucleotide binding]; other site 869215000080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 869215000081 non-specific DNA binding site [nucleotide binding]; other site 869215000082 salt bridge; other site 869215000083 sequence-specific DNA binding site [nucleotide binding]; other site 869215000084 Prophage antirepressor [Transcription]; Region: COG3617 869215000085 BRO family, N-terminal domain; Region: Bro-N; smart01040 869215000086 ORF6C domain; Region: ORF6C; pfam10552 869215000087 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 869215000088 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 869215000089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215000090 Walker A motif; other site 869215000091 ATP binding site [chemical binding]; other site 869215000092 Walker B motif; other site 869215000093 arginine finger; other site 869215000094 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 869215000095 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 869215000096 Int/Topo IB signature motif; other site 869215000097 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 869215000098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869215000099 ATP binding site [chemical binding]; other site 869215000100 putative Mg++ binding site [ion binding]; other site 869215000101 Phage-related protein [Function unknown]; Region: COG4695; cl01923 869215000102 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 869215000103 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 869215000104 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 869215000105 Phage capsid family; Region: Phage_capsid; pfam05065 869215000106 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 869215000107 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 869215000108 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 869215000109 dimer interface [polypeptide binding]; other site 869215000110 Phage-related minor tail protein [Function unknown]; Region: COG5280 869215000111 Phage-related protein [Function unknown]; Region: COG5412 869215000112 membrane protein P6; Region: PHA01399 869215000113 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 869215000114 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 869215000115 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 869215000116 toxin secretion/phage lysis holin; Region: holin_tox_secr; TIGR01593 869215000117 Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682 869215000118 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869215000119 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 869215000120 amidase catalytic site [active] 869215000121 Zn binding residues [ion binding]; other site 869215000122 substrate binding site [chemical binding]; other site 869215000123 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869215000124 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 869215000125 nucleoside/Zn binding site; other site 869215000126 dimer interface [polypeptide binding]; other site 869215000127 catalytic motif [active] 869215000128 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 869215000129 trimer interface [polypeptide binding]; other site 869215000130 active site 869215000131 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869215000132 catalytic core [active] 869215000133 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869215000134 DNA repair protein RadA; Provisional; Region: PRK11823 869215000135 Walker A motif; other site 869215000136 ATP binding site [chemical binding]; other site 869215000137 Walker B motif; other site 869215000138 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 869215000139 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 869215000140 active site clefts [active] 869215000141 zinc binding site [ion binding]; other site 869215000142 dimer interface [polypeptide binding]; other site 869215000143 Frameshift mutation relative to orthologue in TIGR4; TIGR4 orthologue likely to also be a pseudogene due to an independent frameshift mutation in the upstream region 869215000144 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 869215000145 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 869215000146 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869215000147 active site 869215000149 coordinates determined manually using correlation scores plot 869215000150 DNA polymerase I; Provisional; Region: PRK05755 869215000151 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 869215000152 active site 869215000153 metal binding site 1 [ion binding]; metal-binding site 869215000154 putative 5' ssDNA interaction site; other site 869215000155 metal binding site 3; metal-binding site 869215000156 metal binding site 2 [ion binding]; metal-binding site 869215000157 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 869215000158 putative DNA binding site [nucleotide binding]; other site 869215000159 putative metal binding site [ion binding]; other site 869215000160 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 869215000161 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 869215000162 active site 869215000163 DNA binding site [nucleotide binding] 869215000164 catalytic site [active] 869215000165 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 869215000166 Predicted membrane protein [Function unknown]; Region: COG2855 869215000167 aromatic amino acid aminotransferase; Validated; Region: PRK07309 869215000168 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869215000169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215000170 homodimer interface [polypeptide binding]; other site 869215000171 catalytic residue [active] 869215000172 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 869215000173 Recombination protein O N terminal; Region: RecO_N; pfam11967 869215000174 Recombination protein O C terminal; Region: RecO_C; pfam02565 869215000175 putative phosphate acyltransferase; Provisional; Region: PRK05331 869215000178 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 869215000179 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 869215000180 putative active site [active] 869215000181 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869215000182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215000183 Walker A/P-loop; other site 869215000184 ATP binding site [chemical binding]; other site 869215000185 Q-loop/lid; other site 869215000186 ABC transporter signature motif; other site 869215000187 Walker B; other site 869215000188 D-loop; other site 869215000189 H-loop/switch region; other site 869215000190 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 869215000191 HlyD family secretion protein; Region: HlyD_3; pfam13437 869215000192 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 869215000193 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 869215000194 ATP binding site [chemical binding]; other site 869215000195 active site 869215000196 substrate binding site [chemical binding]; other site 869215000197 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 869215000198 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 869215000199 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 869215000200 dimerization interface [polypeptide binding]; other site 869215000201 ATP binding site [chemical binding]; other site 869215000202 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 869215000203 dimerization interface [polypeptide binding]; other site 869215000204 ATP binding site [chemical binding]; other site 869215000205 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 869215000206 putative active site [active] 869215000207 catalytic triad [active] 869215000208 amidophosphoribosyltransferase; Provisional; Region: PRK07272 869215000209 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 869215000210 active site 869215000211 tetramer interface [polypeptide binding]; other site 869215000212 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869215000213 active site 869215000214 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 869215000215 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 869215000216 dimerization interface [polypeptide binding]; other site 869215000217 putative ATP binding site [chemical binding]; other site 869215000218 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 869215000219 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 869215000220 active site 869215000221 substrate binding site [chemical binding]; other site 869215000222 cosubstrate binding site; other site 869215000223 catalytic site [active] 869215000224 VanZ like family; Region: VanZ; pfam04892 869215000225 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 869215000226 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 869215000227 purine monophosphate binding site [chemical binding]; other site 869215000228 dimer interface [polypeptide binding]; other site 869215000229 putative catalytic residues [active] 869215000230 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 869215000231 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 869215000232 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 869215000233 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 869215000234 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 869215000235 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 869215000236 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 869215000237 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 869215000238 ATP-grasp domain; Region: ATP-grasp; pfam02222 869215000239 adenylosuccinate lyase; Provisional; Region: PRK07492 869215000240 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 869215000241 tetramer interface [polypeptide binding]; other site 869215000242 active site 869215000243 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869215000244 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 869215000245 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 869215000246 active site 869215000247 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 869215000248 active site 869215000249 G5 domain; Region: G5; pfam07501 869215000250 G5 domain; Region: G5; pfam07501 869215000251 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 869215000252 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869215000253 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869215000254 DNA-binding site [nucleotide binding]; DNA binding site 869215000255 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 869215000256 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 869215000257 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 869215000258 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869215000259 active site 869215000260 phosphorylation site [posttranslational modification] 869215000261 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 869215000262 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869215000263 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869215000264 active pocket/dimerization site; other site 869215000265 active site 869215000266 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 869215000267 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 869215000268 dimer interface [polypeptide binding]; other site 869215000269 active site 869215000270 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 869215000271 putative active site [active] 869215000272 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 869215000273 active site 869215000274 catalytic residues [active] 869215000275 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 869215000276 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 869215000277 putative metal binding site [ion binding]; other site 869215000278 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869215000279 active site 869215000280 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 869215000281 putative homodimer interface [polypeptide binding]; other site 869215000282 putative homotetramer interface [polypeptide binding]; other site 869215000283 putative allosteric switch controlling residues; other site 869215000284 putative metal binding site [ion binding]; other site 869215000285 putative homodimer-homodimer interface [polypeptide binding]; other site 869215000286 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869215000287 active site residue [active] 869215000288 Similar to C-terminus of a protein from other streptococci 869215000289 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 869215000290 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 869215000291 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 869215000292 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 869215000293 TrkA-N domain; Region: TrkA_N; pfam02254 869215000295 Fibronectin-binding repeat; Region: SSURE; pfam11966 869215000296 Fibronectin-binding repeat; Region: SSURE; pfam11966 869215000297 Fibronectin-binding repeat; Region: SSURE; pfam11966 869215000298 Fibronectin-binding repeat; Region: SSURE; pfam11966 869215000299 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869215000300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869215000301 active site 869215000302 phosphorylation site [posttranslational modification] 869215000303 intermolecular recognition site; other site 869215000304 dimerization interface [polypeptide binding]; other site 869215000305 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869215000306 DNA binding site [nucleotide binding] 869215000307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869215000308 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869215000309 dimerization interface [polypeptide binding]; other site 869215000310 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869215000311 dimer interface [polypeptide binding]; other site 869215000312 phosphorylation site [posttranslational modification] 869215000313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215000314 ATP binding site [chemical binding]; other site 869215000315 Mg2+ binding site [ion binding]; other site 869215000316 G-X-G motif; other site 869215000317 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 869215000318 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 869215000319 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869215000320 RNA binding surface [nucleotide binding]; other site 869215000323 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869215000324 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215000325 dimer interface [polypeptide binding]; other site 869215000326 conserved gate region; other site 869215000327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869215000328 ABC-ATPase subunit interface; other site 869215000329 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869215000330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215000331 dimer interface [polypeptide binding]; other site 869215000332 conserved gate region; other site 869215000333 putative PBP binding loops; other site 869215000334 ABC-ATPase subunit interface; other site 869215000335 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869215000336 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 869215000337 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 869215000338 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 869215000339 active site residue [active] 869215000340 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 869215000341 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 869215000342 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 869215000343 Predicted membrane protein [Function unknown]; Region: COG4709 869215000344 Predicted transcriptional regulators [Transcription]; Region: COG1695 869215000345 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 869215000346 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 869215000347 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869215000348 putative substrate translocation pore; other site 869215000349 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 869215000350 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 869215000351 Ligand binding site; other site 869215000352 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 869215000353 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869215000354 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 869215000355 NAD(P) binding site [chemical binding]; other site 869215000356 homodimer interface [polypeptide binding]; other site 869215000357 substrate binding site [chemical binding]; other site 869215000358 active site 869215000360 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 869215000361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215000362 active site 869215000363 motif I; other site 869215000364 motif II; other site 869215000365 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 869215000366 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 869215000367 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 869215000368 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 869215000369 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 869215000370 putative L-serine binding site [chemical binding]; other site 869215000371 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 869215000372 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869215000373 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869215000374 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215000375 non-specific DNA binding site [nucleotide binding]; other site 869215000376 salt bridge; other site 869215000377 sequence-specific DNA binding site [nucleotide binding]; other site 869215000378 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 869215000379 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 869215000380 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869215000381 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869215000382 Walker A/P-loop; other site 869215000383 ATP binding site [chemical binding]; other site 869215000384 Q-loop/lid; other site 869215000385 ABC transporter signature motif; other site 869215000386 Walker B; other site 869215000387 D-loop; other site 869215000388 H-loop/switch region; other site 869215000389 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869215000390 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869215000391 substrate binding pocket [chemical binding]; other site 869215000392 membrane-bound complex binding site; other site 869215000393 hinge residues; other site 869215000396 Appears to encode the C terminal region of a SPNOXC01480 or SPNOXC1360-type conserved hypothetical protein 869215000397 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869215000398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215000399 non-specific DNA binding site [nucleotide binding]; other site 869215000400 salt bridge; other site 869215000401 sequence-specific DNA binding site [nucleotide binding]; other site 869215000402 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 869215000403 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 869215000404 putative active site [active] 869215000405 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869215000406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215000407 Walker A/P-loop; other site 869215000408 ATP binding site [chemical binding]; other site 869215000409 Q-loop/lid; other site 869215000410 ABC transporter signature motif; other site 869215000411 Walker B; other site 869215000412 D-loop; other site 869215000413 H-loop/switch region; other site 869215000414 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 869215000415 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 869215000416 HlyD family secretion protein; Region: HlyD_3; pfam13437 869215000417 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 869215000418 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869215000419 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869215000420 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869215000421 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869215000422 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869215000423 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869215000424 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869215000425 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869215000426 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 869215000427 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 869215000428 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 869215000429 nudix motif; other site 869215000430 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 869215000431 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 869215000432 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 869215000433 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 869215000434 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 869215000435 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 869215000436 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 869215000437 hypothetical protein; Provisional; Region: PRK13667 869215000438 class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949 869215000439 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 869215000440 Glycoprotease family; Region: Peptidase_M22; pfam00814 869215000441 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 869215000442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869215000443 Coenzyme A binding pocket [chemical binding]; other site 869215000444 UGMP family protein; Validated; Region: PRK09604 869215000445 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 869215000446 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 869215000448 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 869215000449 Helix-turn-helix domain; Region: HTH_38; pfam13936 869215000450 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869215000453 Apparently inactivated by an internal deletion relative to some orthologues 869215000454 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869215000455 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 869215000456 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869215000457 Walker A/P-loop; other site 869215000458 ATP binding site [chemical binding]; other site 869215000459 Q-loop/lid; other site 869215000460 ABC transporter signature motif; other site 869215000461 Walker B; other site 869215000462 D-loop; other site 869215000463 H-loop/switch region; other site 869215000466 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 869215000470 H+ Antiporter protein; Region: 2A0121; TIGR00900 869215000471 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 869215000472 Predicted membrane protein [Function unknown]; Region: COG4392 869215000473 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869215000474 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869215000475 substrate binding pocket [chemical binding]; other site 869215000476 membrane-bound complex binding site; other site 869215000477 hinge residues; other site 869215000478 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 869215000479 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 869215000480 hypothetical protein; Provisional; Region: PRK06446 869215000481 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 869215000482 metal binding site [ion binding]; metal-binding site 869215000483 dimer interface [polypeptide binding]; other site 869215000484 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 869215000485 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 869215000486 Walker A/P-loop; other site 869215000487 ATP binding site [chemical binding]; other site 869215000488 Q-loop/lid; other site 869215000489 ABC transporter signature motif; other site 869215000490 Walker B; other site 869215000491 D-loop; other site 869215000492 H-loop/switch region; other site 869215000493 NIL domain; Region: NIL; pfam09383 869215000494 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 869215000495 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 869215000496 Protein of unknown function, DUF624; Region: DUF624; cl02369 869215000497 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869215000498 HAMP domain; Region: HAMP; pfam00672 869215000499 Histidine kinase; Region: His_kinase; pfam06580 869215000500 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215000501 ATP binding site [chemical binding]; other site 869215000502 Mg2+ binding site [ion binding]; other site 869215000503 G-X-G motif; other site 869215000504 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 869215000505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869215000506 active site 869215000507 phosphorylation site [posttranslational modification] 869215000508 intermolecular recognition site; other site 869215000509 dimerization interface [polypeptide binding]; other site 869215000510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869215000511 flavoprotein NrdI; Provisional; Region: PRK02551 869215000512 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 869215000513 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 869215000514 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869215000515 LytTr DNA-binding domain; Region: LytTR; smart00850 869215000516 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 869215000517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215000518 ATP binding site [chemical binding]; other site 869215000519 Mg2+ binding site [ion binding]; other site 869215000520 G-X-G motif; other site 869215000521 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 869215000522 ATP binding site [chemical binding]; other site 869215000523 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 869215000524 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 869215000525 homopentamer interface [polypeptide binding]; other site 869215000526 active site 869215000527 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 869215000528 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 869215000529 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 869215000530 dimerization interface [polypeptide binding]; other site 869215000531 active site 869215000532 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 869215000533 Lumazine binding domain; Region: Lum_binding; pfam00677 869215000534 Lumazine binding domain; Region: Lum_binding; pfam00677 869215000535 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 869215000536 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 869215000537 catalytic motif [active] 869215000538 Zn binding site [ion binding]; other site 869215000539 RibD C-terminal domain; Region: RibD_C; cl17279 869215000540 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 869215000541 RuvA N terminal domain; Region: RuvA_N; pfam01330 869215000542 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 869215000543 CAAX protease self-immunity; Region: Abi; pfam02517 869215000544 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 869215000545 putative dimer interface [polypeptide binding]; other site 869215000546 catalytic triad [active] 869215000547 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 869215000548 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 869215000549 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 869215000550 Cl binding site [ion binding]; other site 869215000551 oligomer interface [polypeptide binding]; other site 869215000552 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 869215000553 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869215000554 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869215000555 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 869215000556 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 869215000557 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 869215000558 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 869215000559 active site 869215000560 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 869215000561 ArsC family; Region: ArsC; pfam03960 869215000562 putative catalytic residues [active] 869215000563 thiol/disulfide switch; other site 869215000564 hypothetical protein; Provisional; Region: PRK05473 869215000565 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 869215000566 hypothetical protein; Provisional; Region: PRK13678 869215000567 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 869215000568 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869215000569 Bacterial lipoprotein; Region: DUF3642; pfam12182 869215000570 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 869215000571 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 869215000572 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 869215000573 putative active site [active] 869215000574 catalytic site [active] 869215000575 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 869215000576 putative active site [active] 869215000577 catalytic site [active] 869215000578 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 869215000579 ATP cone domain; Region: ATP-cone; pfam03477 869215000580 Class III ribonucleotide reductase; Region: RNR_III; cd01675 869215000581 effector binding site; other site 869215000582 active site 869215000583 Zn binding site [ion binding]; other site 869215000584 glycine loop; other site 869215000585 Predicted acetyltransferase [General function prediction only]; Region: COG3981 869215000586 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869215000587 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 869215000588 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869215000589 FeS/SAM binding site; other site 869215000590 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 869215000591 active site 869215000592 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 869215000593 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 869215000594 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 869215000595 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 869215000596 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 869215000597 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 869215000598 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 869215000599 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 869215000600 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 869215000601 putative translocon binding site; other site 869215000602 protein-rRNA interface [nucleotide binding]; other site 869215000603 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 869215000604 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 869215000605 G-X-X-G motif; other site 869215000606 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 869215000607 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 869215000608 23S rRNA interface [nucleotide binding]; other site 869215000609 5S rRNA interface [nucleotide binding]; other site 869215000610 putative antibiotic binding site [chemical binding]; other site 869215000611 L25 interface [polypeptide binding]; other site 869215000612 L27 interface [polypeptide binding]; other site 869215000613 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 869215000614 23S rRNA interface [nucleotide binding]; other site 869215000615 putative translocon interaction site; other site 869215000616 signal recognition particle (SRP54) interaction site; other site 869215000617 L23 interface [polypeptide binding]; other site 869215000618 trigger factor interaction site; other site 869215000619 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 869215000620 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 869215000621 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 869215000622 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 869215000623 RNA binding site [nucleotide binding]; other site 869215000624 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 869215000625 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 869215000626 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 869215000627 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 869215000628 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 869215000629 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 869215000630 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869215000631 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869215000632 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 869215000633 5S rRNA interface [nucleotide binding]; other site 869215000634 L27 interface [polypeptide binding]; other site 869215000635 23S rRNA interface [nucleotide binding]; other site 869215000636 L5 interface [polypeptide binding]; other site 869215000637 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 869215000638 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 869215000639 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 869215000640 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 869215000641 23S rRNA binding site [nucleotide binding]; other site 869215000642 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 869215000643 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 869215000644 SecY translocase; Region: SecY; pfam00344 869215000645 adenylate kinase; Reviewed; Region: adk; PRK00279 869215000646 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 869215000647 AMP-binding site [chemical binding]; other site 869215000648 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 869215000649 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 869215000650 rRNA binding site [nucleotide binding]; other site 869215000651 predicted 30S ribosome binding site; other site 869215000652 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 869215000653 30S ribosomal protein S13; Region: bact_S13; TIGR03631 869215000654 30S ribosomal protein S11; Validated; Region: PRK05309 869215000655 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 869215000656 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 869215000657 alphaNTD homodimer interface [polypeptide binding]; other site 869215000658 alphaNTD - beta interaction site [polypeptide binding]; other site 869215000659 alphaNTD - beta' interaction site [polypeptide binding]; other site 869215000660 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 869215000661 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 869215000662 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 869215000663 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 869215000664 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869215000665 catalytic core [active] 869215000666 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869215000667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215000668 dimer interface [polypeptide binding]; other site 869215000669 conserved gate region; other site 869215000670 putative PBP binding loops; other site 869215000671 ABC-ATPase subunit interface; other site 869215000672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869215000673 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869215000674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215000675 Walker A/P-loop; other site 869215000676 ATP binding site [chemical binding]; other site 869215000677 Q-loop/lid; other site 869215000678 ABC transporter signature motif; other site 869215000679 Walker B; other site 869215000680 D-loop; other site 869215000681 H-loop/switch region; other site 869215000682 TOBE domain; Region: TOBE_2; pfam08402 869215000683 CDS apparently disrupted by a RUP element insertion 869215000684 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869215000685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869215000686 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 869215000687 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869215000688 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 869215000689 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869215000690 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 869215000691 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 869215000692 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869215000693 active site 869215000694 methionine cluster; other site 869215000695 phosphorylation site [posttranslational modification] 869215000696 metal binding site [ion binding]; metal-binding site 869215000697 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 869215000698 active site 869215000699 P-loop; other site 869215000700 phosphorylation site [posttranslational modification] 869215000701 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869215000702 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 869215000703 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 869215000704 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 869215000705 dimer interface [polypeptide binding]; other site 869215000706 active site 869215000707 glycine loop; other site 869215000708 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 869215000709 active site 869215000710 intersubunit interactions; other site 869215000711 catalytic residue [active] 869215000712 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 869215000713 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 869215000714 dimer interface [polypeptide binding]; other site 869215000715 active site 869215000716 metal binding site [ion binding]; metal-binding site 869215000717 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 869215000718 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 869215000719 HIGH motif; other site 869215000720 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869215000721 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869215000722 active site 869215000723 KMSKS motif; other site 869215000724 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 869215000725 tRNA binding surface [nucleotide binding]; other site 869215000726 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 869215000727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869215000728 Coenzyme A binding pocket [chemical binding]; other site 869215000729 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 869215000730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215000731 Walker A motif; other site 869215000732 ATP binding site [chemical binding]; other site 869215000733 Walker B motif; other site 869215000734 arginine finger; other site 869215000735 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 869215000737 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 869215000738 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 869215000739 catalytic residue [active] 869215000740 putative FPP diphosphate binding site; other site 869215000741 putative FPP binding hydrophobic cleft; other site 869215000742 dimer interface [polypeptide binding]; other site 869215000743 putative IPP diphosphate binding site; other site 869215000744 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 869215000745 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 869215000746 RIP metalloprotease RseP; Region: TIGR00054 869215000747 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 869215000748 active site 869215000749 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 869215000750 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 869215000751 putative substrate binding region [chemical binding]; other site 869215000752 prolyl-tRNA synthetase; Provisional; Region: PRK09194 869215000753 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 869215000754 dimer interface [polypeptide binding]; other site 869215000755 motif 1; other site 869215000756 active site 869215000757 motif 2; other site 869215000758 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 869215000759 putative deacylase active site [active] 869215000760 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869215000761 active site 869215000762 motif 3; other site 869215000763 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 869215000764 anticodon binding site; other site 869215000765 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 869215000766 beta-galactosidase; Region: BGL; TIGR03356 869215000767 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 869215000768 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 869215000769 glutaminase active site [active] 869215000770 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 869215000771 dimer interface [polypeptide binding]; other site 869215000772 active site 869215000773 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 869215000774 dimer interface [polypeptide binding]; other site 869215000775 active site 869215000776 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 869215000777 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 869215000778 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869215000779 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 869215000780 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 869215000781 carbohydrate binding site [chemical binding]; other site 869215000782 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 869215000783 carbohydrate binding site [chemical binding]; other site 869215000784 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 869215000785 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 869215000786 Ca binding site [ion binding]; other site 869215000787 active site 869215000788 catalytic site [active] 869215000789 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 869215000790 S17 interaction site [polypeptide binding]; other site 869215000791 S8 interaction site; other site 869215000792 16S rRNA interaction site [nucleotide binding]; other site 869215000793 streptomycin interaction site [chemical binding]; other site 869215000794 23S rRNA interaction site [nucleotide binding]; other site 869215000795 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 869215000796 30S ribosomal protein S7; Validated; Region: PRK05302 869215000797 elongation factor G; Reviewed; Region: PRK00007 869215000798 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 869215000799 G1 box; other site 869215000800 putative GEF interaction site [polypeptide binding]; other site 869215000801 GTP/Mg2+ binding site [chemical binding]; other site 869215000802 Switch I region; other site 869215000803 G2 box; other site 869215000804 G3 box; other site 869215000805 Switch II region; other site 869215000806 G4 box; other site 869215000807 G5 box; other site 869215000808 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 869215000809 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 869215000810 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 869215000811 DNA polymerase III PolC; Validated; Region: polC; PRK00448 869215000812 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 869215000813 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 869215000814 generic binding surface II; other site 869215000815 generic binding surface I; other site 869215000816 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 869215000817 active site 869215000818 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869215000819 active site 869215000820 catalytic site [active] 869215000821 substrate binding site [chemical binding]; other site 869215000822 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 869215000823 putative PHP Thumb interface [polypeptide binding]; other site 869215000824 active site 869215000825 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 869215000826 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 869215000827 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 869215000828 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 869215000829 Predicted membrane protein [Function unknown]; Region: COG2261 869215000830 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869215000831 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869215000832 RNA binding surface [nucleotide binding]; other site 869215000833 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 869215000834 active site 869215000835 uracil binding [chemical binding]; other site 869215000836 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 869215000837 trimer interface [polypeptide binding]; other site 869215000838 active site 869215000839 G bulge; other site 869215000840 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869215000841 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 869215000842 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 869215000843 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869215000844 active pocket/dimerization site; other site 869215000845 active site 869215000846 phosphorylation site [posttranslational modification] 869215000847 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869215000848 active site 869215000849 phosphorylation site [posttranslational modification] 869215000850 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 869215000851 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 869215000852 NAD binding site [chemical binding]; other site 869215000853 substrate binding site [chemical binding]; other site 869215000854 catalytic Zn binding site [ion binding]; other site 869215000855 tetramer interface [polypeptide binding]; other site 869215000856 structural Zn binding site [ion binding]; other site 869215000857 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869215000858 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215000859 active site 869215000860 motif I; other site 869215000861 motif II; other site 869215000862 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 869215000863 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 869215000864 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 869215000865 dihydropteroate synthase; Region: DHPS; TIGR01496 869215000866 substrate binding pocket [chemical binding]; other site 869215000867 dimer interface [polypeptide binding]; other site 869215000868 inhibitor binding site; inhibition site 869215000869 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 869215000870 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869215000871 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869215000872 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 869215000873 homodecamer interface [polypeptide binding]; other site 869215000874 GTP cyclohydrolase I; Provisional; Region: PLN03044 869215000875 active site 869215000876 putative catalytic site residues [active] 869215000877 zinc binding site [ion binding]; other site 869215000878 GTP-CH-I/GFRP interaction surface; other site 869215000879 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 869215000880 homooctamer interface [polypeptide binding]; other site 869215000881 active site 869215000882 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 869215000883 catalytic center binding site [active] 869215000884 ATP binding site [chemical binding]; other site 869215000885 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 869215000886 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 869215000887 23S rRNA interface [nucleotide binding]; other site 869215000888 L3 interface [polypeptide binding]; other site 869215000889 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 869215000890 Uncharacterized conserved protein [Function unknown]; Region: COG1359 869215000891 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 869215000892 beta-galactosidase; Region: BGL; TIGR03356 869215000893 Uncharacterized conserved protein [Function unknown]; Region: COG4095 869215000894 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 869215000895 active site 869215000896 P-loop; other site 869215000897 phosphorylation site [posttranslational modification] 869215000898 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869215000899 HTH domain; Region: HTH_11; pfam08279 869215000900 Mga helix-turn-helix domain; Region: Mga; pfam05043 869215000901 PRD domain; Region: PRD; pfam00874 869215000902 PRD domain; Region: PRD; pfam00874 869215000903 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869215000904 active site 869215000905 P-loop; other site 869215000906 phosphorylation site [posttranslational modification] 869215000907 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 869215000908 active site 869215000909 phosphorylation site [posttranslational modification] 869215000910 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869215000911 methionine cluster; other site 869215000912 active site 869215000913 phosphorylation site [posttranslational modification] 869215000914 metal binding site [ion binding]; metal-binding site 869215000915 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 869215000916 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869215000918 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 869215000919 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 869215000920 putative active site [active] 869215000921 putative catalytic site [active] 869215000922 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 869215000923 catalytic residues [active] 869215000924 dimer interface [polypeptide binding]; other site 869215000927 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 869215000928 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 869215000929 active site 869215000930 intersubunit interface [polypeptide binding]; other site 869215000931 catalytic residue [active] 869215000932 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869215000933 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 869215000934 substrate binding site [chemical binding]; other site 869215000935 ATP binding site [chemical binding]; other site 869215000936 hypothetical protein; Provisional; Region: PRK09273 869215000937 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 869215000938 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 869215000939 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 869215000940 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 869215000941 NADP binding site [chemical binding]; other site 869215000942 homodimer interface [polypeptide binding]; other site 869215000943 active site 869215000944 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869215000945 active pocket/dimerization site; other site 869215000946 active site 869215000947 phosphorylation site [posttranslational modification] 869215000948 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 869215000949 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869215000950 active site 869215000951 phosphorylation site [posttranslational modification] 869215000952 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 869215000953 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869215000954 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 869215000955 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 869215000956 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869215000957 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869215000958 DNA binding site [nucleotide binding] 869215000959 domain linker motif; other site 869215000960 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 869215000961 putative dimerization interface [polypeptide binding]; other site 869215000962 putative ligand binding site [chemical binding]; other site 869215000963 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 869215000964 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215000965 non-specific DNA binding site [nucleotide binding]; other site 869215000966 salt bridge; other site 869215000967 sequence-specific DNA binding site [nucleotide binding]; other site 869215000968 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 869215000969 MraW methylase family; Region: Methyltransf_5; pfam01795 869215000970 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 869215000971 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 869215000972 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869215000973 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869215000974 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 869215000975 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 869215000976 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 869215000977 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 869215000978 Mg++ binding site [ion binding]; other site 869215000979 putative catalytic motif [active] 869215000980 putative substrate binding site [chemical binding]; other site 869215000981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215000982 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869215000983 Walker A motif; other site 869215000984 ATP binding site [chemical binding]; other site 869215000985 Walker B motif; other site 869215000986 arginine finger; other site 869215000987 UvrB/uvrC motif; Region: UVR; pfam02151 869215000988 MoxR-like ATPases [General function prediction only]; Region: COG0714 869215000989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215000990 Walker A motif; other site 869215000991 ATP binding site [chemical binding]; other site 869215000992 Walker B motif; other site 869215000993 arginine finger; other site 869215000994 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869215000995 LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854 869215000996 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 869215000997 hypothetical protein; Provisional; Region: PRK13663 869215000998 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 869215000999 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 869215001000 Ca binding site [ion binding]; other site 869215001001 active site 869215001002 catalytic site [active] 869215001007 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 869215001008 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 869215001010 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 869215001011 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 869215001012 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 869215001013 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 869215001014 Hyaluronan synthases catalyze polymerization of hyaluronan; Region: GT2_HAS; cd06434 869215001015 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 869215001016 DXD motif; other site 869215001017 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 869215001018 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 869215001019 active site 869215001020 tetramer interface; other site 869215001021 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 869215001022 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 869215001023 active site 869215001024 substrate binding site [chemical binding]; other site 869215001025 metal binding site [ion binding]; metal-binding site 869215001026 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 869215001027 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869215001028 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 869215001029 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869215001030 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 869215001031 Transglycosylase; Region: Transgly; pfam00912 869215001032 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 869215001033 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869215001034 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 869215001035 hypothetical protein; Provisional; Region: PRK13660 869215001036 cell division protein GpsB; Provisional; Region: PRK14127 869215001037 DivIVA domain; Region: DivI1A_domain; TIGR03544 869215001038 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 869215001039 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 869215001040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 869215001041 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 869215001042 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 869215001043 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 869215001044 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869215001045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869215001046 active site 869215001047 phosphorylation site [posttranslational modification] 869215001048 intermolecular recognition site; other site 869215001049 dimerization interface [polypeptide binding]; other site 869215001050 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869215001051 DNA binding site [nucleotide binding] 869215001052 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869215001053 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869215001054 Lantibiotic modifying enzyme [Defense mechanisms]; Region: LcnDR2; COG4403 869215001055 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 869215001056 active site 869215001057 zinc binding site [ion binding]; other site 869215001059 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 869215001060 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869215001061 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869215001062 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 869215001063 diphosphomevalonate decarboxylase; Region: PLN02407 869215001064 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 869215001065 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869215001066 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 869215001067 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 869215001068 homotetramer interface [polypeptide binding]; other site 869215001069 FMN binding site [chemical binding]; other site 869215001070 homodimer contacts [polypeptide binding]; other site 869215001071 putative active site [active] 869215001072 putative substrate binding site [chemical binding]; other site 869215001073 Predicted membrane protein [Function unknown]; Region: COG4758 869215001074 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 869215001075 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869215001076 Histidine kinase; Region: HisKA_3; pfam07730 869215001077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215001078 ATP binding site [chemical binding]; other site 869215001079 Mg2+ binding site [ion binding]; other site 869215001080 G-X-G motif; other site 869215001081 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869215001082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869215001083 active site 869215001084 phosphorylation site [posttranslational modification] 869215001085 intermolecular recognition site; other site 869215001086 dimerization interface [polypeptide binding]; other site 869215001087 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869215001088 DNA binding residues [nucleotide binding] 869215001089 dimerization interface [polypeptide binding]; other site 869215001090 Appears to have been disrupted through the insertion of a BOX element 869215001091 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 869215001092 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869215001093 DNA binding site [nucleotide binding] 869215001094 Int/Topo IB signature motif; other site 869215001095 active site 869215001096 trigger factor; Provisional; Region: tig; PRK01490 869215001097 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 869215001098 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 869215001099 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 869215001100 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 869215001101 DNA binding site [nucleotide binding] 869215001102 AAA domain; Region: AAA_30; pfam13604 869215001103 Family description; Region: UvrD_C_2; pfam13538 869215001104 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 869215001105 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 869215001106 Catalytic site [active] 869215001107 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 869215001108 ribonuclease HIII; Provisional; Region: PRK00996 869215001109 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 869215001110 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 869215001111 RNA/DNA hybrid binding site [nucleotide binding]; other site 869215001112 active site 869215001113 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 869215001114 Colicin V production protein; Region: Colicin_V; pfam02674 869215001115 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 869215001116 MutS domain III; Region: MutS_III; pfam05192 869215001117 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 869215001118 Walker A/P-loop; other site 869215001119 ATP binding site [chemical binding]; other site 869215001120 Q-loop/lid; other site 869215001121 ABC transporter signature motif; other site 869215001122 Walker B; other site 869215001123 D-loop; other site 869215001124 H-loop/switch region; other site 869215001125 Smr domain; Region: Smr; pfam01713 869215001126 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 869215001127 amino acid carrier protein; Region: agcS; TIGR00835 869215001128 Uncharacterized conserved protein [Function unknown]; Region: COG2128 869215001129 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 869215001130 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 869215001131 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 869215001132 gating phenylalanine in ion channel; other site 869215001133 seryl-tRNA synthetase; Provisional; Region: PRK05431 869215001134 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 869215001135 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 869215001136 dimer interface [polypeptide binding]; other site 869215001137 active site 869215001138 motif 1; other site 869215001139 motif 2; other site 869215001140 motif 3; other site 869215001141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 869215001142 aspartate kinase; Reviewed; Region: PRK09034 869215001143 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 869215001144 putative catalytic residues [active] 869215001145 putative nucleotide binding site [chemical binding]; other site 869215001146 putative aspartate binding site [chemical binding]; other site 869215001147 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 869215001148 allosteric regulatory residue; other site 869215001149 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 869215001150 enoyl-CoA hydratase; Provisional; Region: PRK07260 869215001151 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 869215001152 substrate binding site [chemical binding]; other site 869215001153 oxyanion hole (OAH) forming residues; other site 869215001154 trimer interface [polypeptide binding]; other site 869215001155 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869215001156 MarR family; Region: MarR_2; pfam12802 869215001157 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 869215001158 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 869215001159 dimer interface [polypeptide binding]; other site 869215001160 active site 869215001161 CoA binding pocket [chemical binding]; other site 869215001162 acyl carrier protein; Provisional; Region: acpP; PRK00982 869215001163 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 869215001164 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 869215001165 FMN binding site [chemical binding]; other site 869215001166 substrate binding site [chemical binding]; other site 869215001167 putative catalytic residue [active] 869215001168 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 869215001169 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 869215001170 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 869215001171 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 869215001172 NAD(P) binding site [chemical binding]; other site 869215001173 homotetramer interface [polypeptide binding]; other site 869215001174 homodimer interface [polypeptide binding]; other site 869215001175 active site 869215001176 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 869215001177 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 869215001178 dimer interface [polypeptide binding]; other site 869215001179 active site 869215001180 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 869215001181 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 869215001182 carboxyltransferase (CT) interaction site; other site 869215001183 biotinylation site [posttranslational modification]; other site 869215001184 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 869215001185 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 869215001186 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869215001187 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869215001188 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 869215001189 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 869215001190 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 869215001191 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 869215001192 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 869215001193 CAAX protease self-immunity; Region: Abi; pfam02517 869215001195 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 869215001196 putative RNA binding site [nucleotide binding]; other site 869215001197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 869215001198 elongation factor P; Validated; Region: PRK00529 869215001199 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 869215001200 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 869215001201 RNA binding site [nucleotide binding]; other site 869215001202 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 869215001203 RNA binding site [nucleotide binding]; other site 869215001204 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 869215001205 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 869215001206 GatB domain; Region: GatB_Yqey; pfam02637 869215001207 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 869215001208 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 869215001209 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 869215001210 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 869215001211 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 869215001212 G1 box; other site 869215001213 putative GEF interaction site [polypeptide binding]; other site 869215001214 GTP/Mg2+ binding site [chemical binding]; other site 869215001215 Switch I region; other site 869215001216 G2 box; other site 869215001217 G3 box; other site 869215001218 Switch II region; other site 869215001219 G4 box; other site 869215001220 G5 box; other site 869215001221 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 869215001223 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 869215001224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 869215001225 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 869215001226 DAK2 domain; Region: Dak2; pfam02734 869215001227 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 869215001228 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869215001229 PYR/PP interface [polypeptide binding]; other site 869215001230 dimer interface [polypeptide binding]; other site 869215001231 TPP binding site [chemical binding]; other site 869215001232 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869215001233 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 869215001234 TPP-binding site [chemical binding]; other site 869215001235 dimer interface [polypeptide binding]; other site 869215001236 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 869215001237 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 869215001238 putative valine binding site [chemical binding]; other site 869215001239 dimer interface [polypeptide binding]; other site 869215001240 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 869215001241 ketol-acid reductoisomerase; Provisional; Region: PRK05479 869215001242 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 869215001243 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 869215001245 threonine dehydratase; Validated; Region: PRK08639 869215001246 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 869215001247 tetramer interface [polypeptide binding]; other site 869215001248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215001249 catalytic residue [active] 869215001250 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 869215001251 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869215001252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215001253 Walker A/P-loop; other site 869215001254 ATP binding site [chemical binding]; other site 869215001255 Q-loop/lid; other site 869215001256 ABC transporter signature motif; other site 869215001257 Walker B; other site 869215001258 D-loop; other site 869215001259 H-loop/switch region; other site 869215001260 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869215001261 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869215001262 substrate binding pocket [chemical binding]; other site 869215001263 membrane-bound complex binding site; other site 869215001264 hinge residues; other site 869215001265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215001266 dimer interface [polypeptide binding]; other site 869215001267 conserved gate region; other site 869215001268 putative PBP binding loops; other site 869215001269 ABC-ATPase subunit interface; other site 869215001270 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 869215001272 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 869215001273 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 869215001274 active site 869215001275 DNA polymerase IV; Validated; Region: PRK02406 869215001276 DNA binding site [nucleotide binding] 869215001277 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 869215001278 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 869215001280 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 869215001281 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 869215001282 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 869215001283 TrkA-N domain; Region: TrkA_N; pfam02254 869215001284 TrkA-C domain; Region: TrkA_C; pfam02080 869215001285 TrkA-N domain; Region: TrkA_N; pfam02254 869215001286 TrkA-C domain; Region: TrkA_C; pfam02080 869215001287 Uncharacterized conserved protein [Function unknown]; Region: COG1912 869215001288 hypothetical protein; Provisional; Region: PRK13661 869215001289 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869215001290 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869215001291 Walker A/P-loop; other site 869215001292 ATP binding site [chemical binding]; other site 869215001293 Q-loop/lid; other site 869215001294 ABC transporter signature motif; other site 869215001295 Walker B; other site 869215001296 D-loop; other site 869215001297 H-loop/switch region; other site 869215001298 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 869215001299 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869215001300 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869215001301 Walker A/P-loop; other site 869215001302 ATP binding site [chemical binding]; other site 869215001303 Q-loop/lid; other site 869215001304 ABC transporter signature motif; other site 869215001305 Walker B; other site 869215001306 D-loop; other site 869215001307 H-loop/switch region; other site 869215001308 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869215001309 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 869215001310 Predicted membrane protein [Function unknown]; Region: COG3601 869215001311 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 869215001312 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869215001313 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 869215001314 active site 869215001315 ParB-like nuclease domain; Region: ParBc; cl02129 869215001316 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869215001317 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869215001318 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 869215001319 CTP synthetase; Validated; Region: pyrG; PRK05380 869215001320 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 869215001321 Catalytic site [active] 869215001322 active site 869215001323 UTP binding site [chemical binding]; other site 869215001324 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 869215001325 active site 869215001326 putative oxyanion hole; other site 869215001327 catalytic triad [active] 869215001328 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 869215001329 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 869215001330 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 869215001331 PhoU domain; Region: PhoU; pfam01895 869215001332 PhoU domain; Region: PhoU; pfam01895 869215001333 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869215001334 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 869215001335 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 869215001336 putative active site [active] 869215001337 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869215001338 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 869215001339 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 869215001340 G5 domain; Region: G5; pfam07501 869215001341 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 869215001342 Phosphoglycerate kinase; Region: PGK; pfam00162 869215001343 substrate binding site [chemical binding]; other site 869215001344 hinge regions; other site 869215001345 ADP binding site [chemical binding]; other site 869215001346 catalytic site [active] 869215001347 Predicted membrane protein [Function unknown]; Region: COG4129 869215001348 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 869215001349 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 869215001350 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 869215001351 DNA binding residues [nucleotide binding] 869215001352 putative dimer interface [polypeptide binding]; other site 869215001353 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 869215001354 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 869215001355 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 869215001356 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869215001357 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869215001358 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869215001359 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 869215001360 VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196 869215001361 Int/Topo IB signature motif; other site 869215001363 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 869215001364 HsdM N-terminal domain; Region: HsdM_N; pfam12161 869215001365 Methyltransferase domain; Region: Methyltransf_26; pfam13659 869215001366 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 869215001367 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 869215001368 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869215001369 ATP binding site [chemical binding]; other site 869215001370 putative Mg++ binding site [ion binding]; other site 869215001371 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 869215001372 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 869215001373 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 869215001374 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 869215001375 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 869215001376 dimer interface [polypeptide binding]; other site 869215001377 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 869215001378 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 869215001379 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 869215001380 nucleotide binding site [chemical binding]; other site 869215001381 NEF interaction site [polypeptide binding]; other site 869215001382 SBD interface [polypeptide binding]; other site 869215001383 chaperone protein DnaJ; Provisional; Region: PRK14276 869215001384 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869215001385 HSP70 interaction site [polypeptide binding]; other site 869215001386 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 869215001387 substrate binding site [polypeptide binding]; other site 869215001388 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 869215001389 Zn binding sites [ion binding]; other site 869215001390 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 869215001391 substrate binding site [polypeptide binding]; other site 869215001392 dimer interface [polypeptide binding]; other site 869215001393 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 869215001394 HIT family signature motif; other site 869215001395 catalytic residue [active] 869215001396 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 869215001397 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869215001398 Walker A/P-loop; other site 869215001399 ATP binding site [chemical binding]; other site 869215001400 Q-loop/lid; other site 869215001401 ABC transporter signature motif; other site 869215001402 Walker B; other site 869215001403 D-loop; other site 869215001404 H-loop/switch region; other site 869215001405 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 869215001406 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 869215001407 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869215001408 LytTr DNA-binding domain; Region: LytTR; pfam04397 869215001409 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869215001410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869215001411 active site 869215001412 phosphorylation site [posttranslational modification] 869215001413 intermolecular recognition site; other site 869215001414 dimerization interface [polypeptide binding]; other site 869215001415 LytTr DNA-binding domain; Region: LytTR; pfam04397 869215001416 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869215001417 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215001418 ATP binding site [chemical binding]; other site 869215001419 Mg2+ binding site [ion binding]; other site 869215001420 G-X-G motif; other site 869215001421 COMC family; Region: ComC; pfam03047 869215001422 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 869215001423 HlyD family secretion protein; Region: HlyD_3; pfam13437 869215001425 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 869215001426 putative active site [active] 869215001427 class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949 869215001429 CAAX protease self-immunity; Region: Abi; pfam02517 869215001430 CAAX protease self-immunity; Region: Abi; pfam02517 869215001431 Phosphotransferase enzyme family; Region: APH; pfam01636 869215001432 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 869215001433 substrate binding site [chemical binding]; other site 869215001434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215001435 S-adenosylmethionine binding site [chemical binding]; other site 869215001436 ribosome maturation protein RimP; Reviewed; Region: PRK00092 869215001437 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 869215001438 putative oligomer interface [polypeptide binding]; other site 869215001439 putative RNA binding site [nucleotide binding]; other site 869215001440 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 869215001441 NusA N-terminal domain; Region: NusA_N; pfam08529 869215001442 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 869215001443 RNA binding site [nucleotide binding]; other site 869215001444 homodimer interface [polypeptide binding]; other site 869215001445 NusA-like KH domain; Region: KH_5; pfam13184 869215001446 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 869215001447 G-X-X-G motif; other site 869215001448 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 869215001449 putative RNA binding cleft [nucleotide binding]; other site 869215001450 hypothetical protein; Provisional; Region: PRK07283 869215001451 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 869215001452 translation initiation factor IF-2; Region: IF-2; TIGR00487 869215001453 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 869215001454 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 869215001455 G1 box; other site 869215001456 putative GEF interaction site [polypeptide binding]; other site 869215001457 GTP/Mg2+ binding site [chemical binding]; other site 869215001458 Switch I region; other site 869215001459 G2 box; other site 869215001460 G3 box; other site 869215001461 Switch II region; other site 869215001462 G4 box; other site 869215001463 G5 box; other site 869215001464 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 869215001465 Translation-initiation factor 2; Region: IF-2; pfam11987 869215001466 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 869215001467 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 869215001468 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 869215001469 Uncharacterized conserved protein [Function unknown]; Region: COG2461 869215001470 Family of unknown function (DUF438); Region: DUF438; pfam04282 869215001471 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 869215001472 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 869215001473 putative active site [active] 869215001474 heme pocket [chemical binding]; other site 869215001475 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 869215001476 hypothetical protein; Provisional; Region: PRK07758 869215001477 Flavin Reductases; Region: FlaRed; cl00801 869215001478 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869215001479 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869215001480 Coenzyme A binding pocket [chemical binding]; other site 869215001481 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 869215001482 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869215001483 active site 869215001484 HIGH motif; other site 869215001485 nucleotide binding site [chemical binding]; other site 869215001486 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869215001487 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 869215001488 active site 869215001489 KMSKS motif; other site 869215001490 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 869215001491 tRNA binding surface [nucleotide binding]; other site 869215001492 anticodon binding site; other site 869215001493 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 869215001494 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 869215001495 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 869215001496 Fic/DOC family; Region: Fic; pfam02661 869215001499 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 869215001500 putative active site [active] 869215001501 catalytic site [active] 869215001502 transcriptional antiterminator BglG; Provisional; Region: PRK09772 869215001503 CAT RNA binding domain; Region: CAT_RBD; smart01061 869215001504 PRD domain; Region: PRD; pfam00874 869215001505 PRD domain; Region: PRD; pfam00874 869215001506 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 869215001507 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869215001508 active site turn [active] 869215001509 phosphorylation site [posttranslational modification] 869215001510 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869215001511 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 869215001512 HPr interaction site; other site 869215001513 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869215001514 active site 869215001515 phosphorylation site [posttranslational modification] 869215001516 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 869215001517 beta-galactosidase; Region: BGL; TIGR03356 869215001518 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 869215001519 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 869215001520 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 869215001521 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 869215001522 dimer interface [polypeptide binding]; other site 869215001523 motif 1; other site 869215001524 active site 869215001525 motif 2; other site 869215001526 motif 3; other site 869215001527 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869215001528 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869215001529 Coenzyme A binding pocket [chemical binding]; other site 869215001530 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 869215001531 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 869215001532 putative tRNA-binding site [nucleotide binding]; other site 869215001533 B3/4 domain; Region: B3_4; pfam03483 869215001534 tRNA synthetase B5 domain; Region: B5; smart00874 869215001535 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 869215001536 dimer interface [polypeptide binding]; other site 869215001537 motif 1; other site 869215001538 motif 3; other site 869215001539 motif 2; other site 869215001540 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 869215001541 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 869215001542 putative catalytic site [active] 869215001543 putative metal binding site [ion binding]; other site 869215001544 putative phosphate binding site [ion binding]; other site 869215001546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215001547 non-specific DNA binding site [nucleotide binding]; other site 869215001548 salt bridge; other site 869215001549 sequence-specific DNA binding site [nucleotide binding]; other site 869215001550 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 869215001551 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 869215001552 THF binding site; other site 869215001553 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 869215001554 substrate binding site [chemical binding]; other site 869215001555 THF binding site; other site 869215001556 zinc-binding site [ion binding]; other site 869215001557 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 869215001558 FAD binding site [chemical binding]; other site 869215001559 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 869215001560 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 869215001561 RNase E interface [polypeptide binding]; other site 869215001562 trimer interface [polypeptide binding]; other site 869215001563 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 869215001564 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 869215001565 RNase E interface [polypeptide binding]; other site 869215001566 trimer interface [polypeptide binding]; other site 869215001567 active site 869215001568 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 869215001569 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 869215001570 RNA binding site [nucleotide binding]; other site 869215001571 domain interface; other site 869215001572 serine O-acetyltransferase; Region: cysE; TIGR01172 869215001573 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 869215001574 trimer interface [polypeptide binding]; other site 869215001575 active site 869215001576 substrate binding site [chemical binding]; other site 869215001577 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869215001578 Coenzyme A binding pocket [chemical binding]; other site 869215001579 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869215001580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869215001581 Coenzyme A binding pocket [chemical binding]; other site 869215001582 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 869215001583 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869215001584 active site 869215001585 HIGH motif; other site 869215001586 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869215001587 KMSKS motif; other site 869215001588 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 869215001589 tRNA binding surface [nucleotide binding]; other site 869215001590 anticodon binding site; other site 869215001591 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 869215001592 active site 869215001593 metal binding site [ion binding]; metal-binding site 869215001594 dimerization interface [polypeptide binding]; other site 869215001595 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 869215001596 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 869215001597 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 869215001599 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869215001600 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869215001601 FtsX-like permease family; Region: FtsX; pfam02687 869215001602 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869215001603 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869215001604 Walker A/P-loop; other site 869215001605 ATP binding site [chemical binding]; other site 869215001606 Q-loop/lid; other site 869215001607 ABC transporter signature motif; other site 869215001608 Walker B; other site 869215001609 D-loop; other site 869215001610 H-loop/switch region; other site 869215001611 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869215001612 FtsX-like permease family; Region: FtsX; pfam02687 869215001613 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869215001614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869215001615 active site 869215001616 phosphorylation site [posttranslational modification] 869215001617 intermolecular recognition site; other site 869215001618 dimerization interface [polypeptide binding]; other site 869215001619 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869215001620 DNA binding site [nucleotide binding] 869215001621 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869215001622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869215001623 dimerization interface [polypeptide binding]; other site 869215001624 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869215001625 dimer interface [polypeptide binding]; other site 869215001626 phosphorylation site [posttranslational modification] 869215001627 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215001628 ATP binding site [chemical binding]; other site 869215001629 Mg2+ binding site [ion binding]; other site 869215001630 G-X-G motif; other site 869215001631 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 869215001632 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 869215001633 intersubunit interface [polypeptide binding]; other site 869215001634 active site 869215001635 zinc binding site [ion binding]; other site 869215001636 Na+ binding site [ion binding]; other site 869215001638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215001639 dimer interface [polypeptide binding]; other site 869215001640 conserved gate region; other site 869215001641 putative PBP binding loops; other site 869215001642 ABC-ATPase subunit interface; other site 869215001643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215001644 dimer interface [polypeptide binding]; other site 869215001645 conserved gate region; other site 869215001646 putative PBP binding loops; other site 869215001647 ABC-ATPase subunit interface; other site 869215001648 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869215001649 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869215001650 substrate binding pocket [chemical binding]; other site 869215001651 membrane-bound complex binding site; other site 869215001652 hinge residues; other site 869215001653 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869215001654 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869215001655 Walker A/P-loop; other site 869215001656 ATP binding site [chemical binding]; other site 869215001657 Q-loop/lid; other site 869215001658 ABC transporter signature motif; other site 869215001659 Walker B; other site 869215001660 D-loop; other site 869215001661 H-loop/switch region; other site 869215001662 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 869215001663 DHH family; Region: DHH; pfam01368 869215001664 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 869215001665 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 869215001666 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869215001667 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 869215001668 Predicted esterase [General function prediction only]; Region: COG0627 869215001669 S-formylglutathione hydrolase; Region: PLN02442 869215001670 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 869215001671 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 869215001672 FemAB family; Region: FemAB; pfam02388 869215001673 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 869215001674 active site 869215001675 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 869215001676 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 869215001677 GIY-YIG motif/motif A; other site 869215001678 active site 869215001679 catalytic site [active] 869215001680 putative DNA binding site [nucleotide binding]; other site 869215001681 metal binding site [ion binding]; metal-binding site 869215001682 UvrB/uvrC motif; Region: UVR; pfam02151 869215001683 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 869215001684 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869215001685 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 869215001686 active site 869215001687 metal binding site [ion binding]; metal-binding site 869215001688 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869215001689 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869215001690 substrate binding pocket [chemical binding]; other site 869215001691 membrane-bound complex binding site; other site 869215001692 hinge residues; other site 869215001693 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 869215001694 dimer interface [polypeptide binding]; other site 869215001695 FMN binding site [chemical binding]; other site 869215001696 dipeptidase PepV; Reviewed; Region: PRK07318 869215001697 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 869215001698 active site 869215001699 metal binding site [ion binding]; metal-binding site 869215001700 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 869215001701 putative uracil binding site [chemical binding]; other site 869215001702 putative active site [active] 869215001703 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869215001705 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 869215001706 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 869215001707 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 869215001708 putative oligomer interface [polypeptide binding]; other site 869215001709 putative active site [active] 869215001710 metal binding site [ion binding]; metal-binding site 869215001712 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 869215001713 DDE superfamily endonuclease; Region: DDE_4; cl17710 869215001715 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 869215001716 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 869215001717 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 869215001718 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 869215001719 23S rRNA interface [nucleotide binding]; other site 869215001720 L7/L12 interface [polypeptide binding]; other site 869215001721 putative thiostrepton binding site; other site 869215001722 L25 interface [polypeptide binding]; other site 869215001723 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 869215001724 mRNA/rRNA interface [nucleotide binding]; other site 869215001727 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 869215001728 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215001729 Walker A/P-loop; other site 869215001730 ATP binding site [chemical binding]; other site 869215001731 Q-loop/lid; other site 869215001732 ABC transporter signature motif; other site 869215001733 Walker B; other site 869215001734 D-loop; other site 869215001735 H-loop/switch region; other site 869215001736 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 869215001737 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 869215001738 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 869215001739 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 869215001740 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 869215001741 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 869215001742 putative active site [active] 869215001743 catalytic triad [active] 869215001744 PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819 869215001745 PA/protease or protease-like domain interface [polypeptide binding]; other site 869215001746 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 869215001747 catalytic residues [active] 869215001748 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 869215001749 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 869215001750 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869215001751 active site 869215001752 phosphorylation site [posttranslational modification] 869215001753 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 869215001754 active site 869215001755 P-loop; other site 869215001756 phosphorylation site [posttranslational modification] 869215001757 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 869215001758 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 869215001759 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869215001760 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 869215001761 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 869215001762 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 869215001763 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 869215001764 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869215001765 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869215001766 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869215001767 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869215001768 G5 domain; Region: G5; pfam07501 869215001769 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869215001770 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 869215001771 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869215001772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869215001773 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 869215001774 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 869215001775 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 869215001776 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 869215001777 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 869215001778 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 869215001779 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 869215001780 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 869215001781 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 869215001782 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 869215001783 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869215001784 catalytic residues [active] 869215001785 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 869215001786 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 869215001787 SelR domain; Region: SelR; pfam01641 869215001788 Response regulator receiver domain; Region: Response_reg; pfam00072 869215001789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869215001790 active site 869215001791 phosphorylation site [posttranslational modification] 869215001792 intermolecular recognition site; other site 869215001793 dimerization interface [polypeptide binding]; other site 869215001794 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869215001795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869215001796 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869215001797 Cache domain; Region: Cache_1; pfam02743 869215001798 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869215001799 dimerization interface [polypeptide binding]; other site 869215001800 Histidine kinase; Region: His_kinase; pfam06580 869215001801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215001802 ATP binding site [chemical binding]; other site 869215001803 Mg2+ binding site [ion binding]; other site 869215001804 G-X-G motif; other site 869215001805 hypothetical protein; Provisional; Region: PRK13690 869215001806 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 869215001807 MARCKS family; Region: MARCKS; pfam02063 869215001808 G5 domain; Region: G5; pfam07501 869215001809 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 869215001810 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 869215001811 aminodeoxychorismate synthase; Provisional; Region: PRK07508 869215001812 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 869215001813 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 869215001814 substrate-cofactor binding pocket; other site 869215001815 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 869215001816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215001817 catalytic residue [active] 869215001818 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 869215001819 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869215001820 Excalibur calcium-binding domain; Region: Excalibur; smart00894 869215001821 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 869215001822 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869215001823 nucleotide binding site [chemical binding]; other site 869215001824 thymidylate synthase; Reviewed; Region: thyA; PRK01827 869215001825 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 869215001826 dimerization interface [polypeptide binding]; other site 869215001827 active site 869215001828 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 869215001829 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 869215001830 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 869215001831 GTPases [General function prediction only]; Region: HflX; COG2262 869215001832 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 869215001833 HflX GTPase family; Region: HflX; cd01878 869215001834 G1 box; other site 869215001835 GTP/Mg2+ binding site [chemical binding]; other site 869215001836 Switch I region; other site 869215001837 G2 box; other site 869215001838 G3 box; other site 869215001839 Switch II region; other site 869215001840 G4 box; other site 869215001841 G5 box; other site 869215001842 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 869215001843 ribonuclease Z; Region: RNase_Z; TIGR02651 869215001844 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 869215001845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869215001846 NAD(P) binding site [chemical binding]; other site 869215001847 active site 869215001848 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869215001849 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869215001850 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869215001851 dimerization interface [polypeptide binding]; other site 869215001852 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 869215001853 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869215001854 active site residue [active] 869215001855 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869215001856 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 869215001857 RNA binding surface [nucleotide binding]; other site 869215001858 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 869215001859 active site 869215001860 uracil binding [chemical binding]; other site 869215001861 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 869215001862 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 869215001863 G1 box; other site 869215001864 putative GEF interaction site [polypeptide binding]; other site 869215001865 GTP/Mg2+ binding site [chemical binding]; other site 869215001866 Switch I region; other site 869215001867 G2 box; other site 869215001868 G3 box; other site 869215001869 Switch II region; other site 869215001870 G4 box; other site 869215001871 G5 box; other site 869215001872 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 869215001873 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 869215001874 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 869215001875 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 869215001876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 869215001877 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 869215001878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215001879 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869215001880 Walker A/P-loop; other site 869215001881 ATP binding site [chemical binding]; other site 869215001882 Q-loop/lid; other site 869215001883 ABC transporter signature motif; other site 869215001884 Walker B; other site 869215001885 D-loop; other site 869215001886 H-loop/switch region; other site 869215001887 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 869215001888 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 869215001889 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869215001890 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869215001891 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 869215001892 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 869215001893 homodimer interface [polypeptide binding]; other site 869215001894 active site 869215001895 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 869215001896 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 869215001897 Cell division protein FtsQ; Region: FtsQ; pfam03799 869215001898 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 869215001899 active site 869215001900 dimer interface [polypeptide binding]; other site 869215001901 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869215001902 active site 869215001903 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869215001904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215001905 Walker A/P-loop; other site 869215001906 ATP binding site [chemical binding]; other site 869215001907 Q-loop/lid; other site 869215001908 ABC transporter signature motif; other site 869215001909 Walker B; other site 869215001910 D-loop; other site 869215001911 H-loop/switch region; other site 869215001912 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 869215001913 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869215001914 substrate binding pocket [chemical binding]; other site 869215001915 membrane-bound complex binding site; other site 869215001916 hinge residues; other site 869215001918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215001919 dimer interface [polypeptide binding]; other site 869215001920 conserved gate region; other site 869215001921 putative PBP binding loops; other site 869215001922 ABC-ATPase subunit interface; other site 869215001923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215001924 dimer interface [polypeptide binding]; other site 869215001925 conserved gate region; other site 869215001926 putative PBP binding loops; other site 869215001927 ABC-ATPase subunit interface; other site 869215001928 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869215001929 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 869215001930 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 869215001931 dimer interface [polypeptide binding]; other site 869215001932 putative anticodon binding site; other site 869215001933 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 869215001934 motif 1; other site 869215001935 active site 869215001936 motif 2; other site 869215001937 motif 3; other site 869215001938 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 869215001939 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 869215001940 teramer interface [polypeptide binding]; other site 869215001941 active site 869215001942 FMN binding site [chemical binding]; other site 869215001943 catalytic residues [active] 869215001944 Putative transcription activator [Transcription]; Region: TenA; COG0819 869215001945 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 869215001946 substrate binding site [chemical binding]; other site 869215001947 multimerization interface [polypeptide binding]; other site 869215001948 ATP binding site [chemical binding]; other site 869215001949 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 869215001950 thiamine phosphate binding site [chemical binding]; other site 869215001951 active site 869215001952 pyrophosphate binding site [ion binding]; other site 869215001953 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 869215001954 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869215001955 Walker A/P-loop; other site 869215001956 ATP binding site [chemical binding]; other site 869215001957 ABC transporter; Region: ABC_tran; pfam00005 869215001958 Q-loop/lid; other site 869215001959 ABC transporter signature motif; other site 869215001960 Walker B; other site 869215001961 D-loop; other site 869215001962 H-loop/switch region; other site 869215001963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215001964 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 869215001965 Walker A/P-loop; other site 869215001966 ATP binding site [chemical binding]; other site 869215001967 Q-loop/lid; other site 869215001968 ABC transporter signature motif; other site 869215001969 Walker B; other site 869215001970 D-loop; other site 869215001971 H-loop/switch region; other site 869215001972 Putative transcription activator [Transcription]; Region: TenA; COG0819 869215001973 Predicted membrane protein [Function unknown]; Region: COG4732 869215001974 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 869215001975 substrate binding site [chemical binding]; other site 869215001976 multimerization interface [polypeptide binding]; other site 869215001977 ATP binding site [chemical binding]; other site 869215001978 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 869215001979 thiamine phosphate binding site [chemical binding]; other site 869215001980 active site 869215001981 pyrophosphate binding site [ion binding]; other site 869215001982 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 869215001983 dimer interface [polypeptide binding]; other site 869215001984 substrate binding site [chemical binding]; other site 869215001985 ATP binding site [chemical binding]; other site 869215001986 Predicted transcriptional regulator [Transcription]; Region: COG3682 869215001987 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 869215001988 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 869215001989 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 869215001990 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 869215001991 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 869215001992 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869215001993 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 869215001994 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 869215001995 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 869215001996 PYR/PP interface [polypeptide binding]; other site 869215001997 dimer interface [polypeptide binding]; other site 869215001998 tetramer interface [polypeptide binding]; other site 869215001999 TPP binding site [chemical binding]; other site 869215002000 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869215002001 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 869215002002 TPP-binding site [chemical binding]; other site 869215002003 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869215002004 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869215002005 active site 869215002008 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 869215002009 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 869215002010 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 869215002012 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 869215002013 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 869215002014 dimer interface [polypeptide binding]; other site 869215002015 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 869215002016 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 869215002017 putative active site [active] 869215002018 nucleotide binding site [chemical binding]; other site 869215002019 nudix motif; other site 869215002020 putative metal binding site [ion binding]; other site 869215002021 HI0933-like protein; Region: HI0933_like; pfam03486 869215002022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 869215002023 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 869215002024 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869215002025 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869215002026 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 869215002027 catalytic motif [active] 869215002028 Zn binding site [ion binding]; other site 869215002029 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869215002030 active site 869215002031 Clp protease; Region: CLP_protease; pfam00574 869215002032 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 869215002033 oligomer interface [polypeptide binding]; other site 869215002034 active site residues [active] 869215002035 hypothetical protein; Provisional; Region: PRK02302 869215002036 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 869215002037 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 869215002038 putative ligand binding site [chemical binding]; other site 869215002039 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869215002040 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 869215002041 TM-ABC transporter signature motif; other site 869215002042 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 869215002043 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 869215002044 TM-ABC transporter signature motif; other site 869215002045 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 869215002046 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 869215002047 Walker A/P-loop; other site 869215002048 ATP binding site [chemical binding]; other site 869215002049 Q-loop/lid; other site 869215002050 ABC transporter signature motif; other site 869215002051 Walker B; other site 869215002052 D-loop; other site 869215002053 H-loop/switch region; other site 869215002054 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 869215002055 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 869215002056 Walker A/P-loop; other site 869215002057 ATP binding site [chemical binding]; other site 869215002058 Q-loop/lid; other site 869215002059 ABC transporter signature motif; other site 869215002060 Walker B; other site 869215002061 D-loop; other site 869215002062 H-loop/switch region; other site 869215002063 FOG: CBS domain [General function prediction only]; Region: COG0517 869215002064 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 869215002065 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 869215002066 PCRF domain; Region: PCRF; pfam03462 869215002067 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 869215002068 RF-1 domain; Region: RF-1; pfam00472 869215002069 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 869215002070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215002071 Walker A/P-loop; other site 869215002072 ATP binding site [chemical binding]; other site 869215002073 Q-loop/lid; other site 869215002074 ABC transporter signature motif; other site 869215002075 Walker B; other site 869215002076 D-loop; other site 869215002077 H-loop/switch region; other site 869215002078 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 869215002079 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 869215002080 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869215002081 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 869215002082 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869215002083 active site turn [active] 869215002084 phosphorylation site [posttranslational modification] 869215002085 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 869215002086 HPr interaction site; other site 869215002087 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869215002088 active site 869215002089 phosphorylation site [posttranslational modification] 869215002090 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 869215002091 putative catalytic site [active] 869215002092 putative metal binding site [ion binding]; other site 869215002093 putative phosphate binding site [ion binding]; other site 869215002094 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 869215002095 DEAD-like helicases superfamily; Region: DEXDc; smart00487 869215002096 ATP binding site [chemical binding]; other site 869215002097 Mg++ binding site [ion binding]; other site 869215002098 motif III; other site 869215002099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869215002100 nucleotide binding region [chemical binding]; other site 869215002101 ATP-binding site [chemical binding]; other site 869215002102 S-adenosylmethionine synthetase; Validated; Region: PRK05250 869215002103 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 869215002104 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 869215002105 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 869215002106 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 869215002107 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 869215002108 active site 869215002109 FMN binding site [chemical binding]; other site 869215002110 substrate binding site [chemical binding]; other site 869215002111 catalytic residues [active] 869215002112 homodimer interface [polypeptide binding]; other site 869215002113 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 869215002114 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 869215002115 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 869215002116 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 869215002117 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 869215002118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 869215002119 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 869215002120 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869215002121 FeS/SAM binding site; other site 869215002122 VanZ like family; Region: VanZ; pfam04892 869215002123 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869215002124 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869215002125 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869215002126 ABC transporter; Region: ABC_tran_2; pfam12848 869215002127 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869215002128 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 869215002129 active site 869215002130 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 869215002131 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 869215002132 KH domain; Region: KH_4; pfam13083 869215002133 G-X-X-G motif; other site 869215002134 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 869215002135 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 869215002136 RimM N-terminal domain; Region: RimM; pfam01782 869215002137 PRC-barrel domain; Region: PRC; pfam05239 869215002138 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 869215002139 ATP cone domain; Region: ATP-cone; pfam03477 869215002140 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 869215002141 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 869215002142 glutathione reductase; Validated; Region: PRK06116 869215002143 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869215002144 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869215002145 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869215002146 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 869215002147 HlyD family secretion protein; Region: HlyD_3; pfam13437 869215002148 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869215002149 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869215002150 Walker A/P-loop; other site 869215002151 ATP binding site [chemical binding]; other site 869215002152 Q-loop/lid; other site 869215002153 ABC transporter signature motif; other site 869215002154 Walker B; other site 869215002155 D-loop; other site 869215002156 H-loop/switch region; other site 869215002157 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869215002158 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869215002159 FtsX-like permease family; Region: FtsX; pfam02687 869215002160 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 869215002161 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 869215002162 active site 869215002163 HIGH motif; other site 869215002164 KMSKS motif; other site 869215002165 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 869215002166 tRNA binding surface [nucleotide binding]; other site 869215002167 anticodon binding site; other site 869215002168 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 869215002169 dimer interface [polypeptide binding]; other site 869215002170 putative tRNA-binding site [nucleotide binding]; other site 869215002171 Predicted transcriptional regulators [Transcription]; Region: COG1695 869215002172 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 869215002173 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869215002174 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869215002175 active site 869215002176 catalytic tetrad [active] 869215002177 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 869215002178 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 869215002179 classical (c) SDRs; Region: SDR_c; cd05233 869215002180 NAD(P) binding site [chemical binding]; other site 869215002181 active site 869215002182 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 869215002183 nudix motif; other site 869215002184 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 869215002185 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 869215002186 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869215002187 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 869215002188 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 869215002189 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 869215002190 Zn binding site [ion binding]; other site 869215002191 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869215002192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869215002193 active site 869215002194 phosphorylation site [posttranslational modification] 869215002195 intermolecular recognition site; other site 869215002196 dimerization interface [polypeptide binding]; other site 869215002197 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869215002198 DNA binding site [nucleotide binding] 869215002199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869215002200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869215002201 dimer interface [polypeptide binding]; other site 869215002202 phosphorylation site [posttranslational modification] 869215002203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215002204 ATP binding site [chemical binding]; other site 869215002205 Mg2+ binding site [ion binding]; other site 869215002206 G-X-G motif; other site 869215002207 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 869215002208 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869215002209 Peptidase family U32; Region: Peptidase_U32; pfam01136 869215002210 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 869215002211 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869215002212 active site 869215002213 catalytic site [active] 869215002214 substrate binding site [chemical binding]; other site 869215002215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869215002216 ATP binding site [chemical binding]; other site 869215002217 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 869215002218 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 869215002219 DJ-1 family protein; Region: not_thiJ; TIGR01383 869215002220 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 869215002221 conserved cys residue [active] 869215002222 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 869215002223 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215002224 motif II; other site 869215002225 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 869215002226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215002227 Mg2+ binding site [ion binding]; other site 869215002228 G-X-G motif; other site 869215002229 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 869215002230 anchoring element; other site 869215002231 dimer interface [polypeptide binding]; other site 869215002232 ATP binding site [chemical binding]; other site 869215002233 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 869215002234 active site 869215002235 putative metal-binding site [ion binding]; other site 869215002236 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 869215002237 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 869215002239 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 869215002240 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 869215002241 nudix motif; other site 869215002243 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 869215002244 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215002245 Walker A motif; other site 869215002246 ATP binding site [chemical binding]; other site 869215002247 Walker B motif; other site 869215002248 arginine finger; other site 869215002249 UvrB/uvrC motif; Region: UVR; pfam02151 869215002250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215002251 Walker A motif; other site 869215002252 ATP binding site [chemical binding]; other site 869215002253 Walker B motif; other site 869215002254 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869215002255 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215002256 dimer interface [polypeptide binding]; other site 869215002257 conserved gate region; other site 869215002258 ABC-ATPase subunit interface; other site 869215002259 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 869215002260 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869215002261 Walker A/P-loop; other site 869215002262 ATP binding site [chemical binding]; other site 869215002263 Q-loop/lid; other site 869215002264 ABC transporter signature motif; other site 869215002265 Walker B; other site 869215002266 D-loop; other site 869215002267 H-loop/switch region; other site 869215002268 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 869215002269 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 869215002270 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 869215002271 homodimer interface [polypeptide binding]; other site 869215002272 NADP binding site [chemical binding]; other site 869215002273 substrate binding site [chemical binding]; other site 869215002274 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 869215002275 putative substrate binding site [chemical binding]; other site 869215002276 putative ATP binding site [chemical binding]; other site 869215002277 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 869215002278 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869215002279 active site 869215002280 dimer interface [polypeptide binding]; other site 869215002281 phosphopentomutase; Provisional; Region: PRK05362 869215002282 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 869215002283 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 869215002284 purine nucleoside phosphorylase; Provisional; Region: PRK08202 869215002286 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 869215002287 topology modulation protein; Provisional; Region: PRK07261 869215002288 AAA domain; Region: AAA_17; pfam13207 869215002289 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 869215002290 pantothenate kinase; Provisional; Region: PRK05439 869215002291 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 869215002292 ATP-binding site [chemical binding]; other site 869215002293 CoA-binding site [chemical binding]; other site 869215002294 Mg2+-binding site [ion binding]; other site 869215002295 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869215002296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215002297 S-adenosylmethionine binding site [chemical binding]; other site 869215002298 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 869215002299 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869215002300 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869215002301 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 869215002302 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 869215002303 intersubunit interface [polypeptide binding]; other site 869215002304 active site 869215002305 catalytic residue [active] 869215002306 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 869215002307 active site 869215002308 catalytic motif [active] 869215002309 Zn binding site [ion binding]; other site 869215002310 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 869215002311 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 869215002312 ligand binding site [chemical binding]; other site 869215002313 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 869215002314 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869215002315 Walker A/P-loop; other site 869215002316 ATP binding site [chemical binding]; other site 869215002317 Q-loop/lid; other site 869215002318 ABC transporter signature motif; other site 869215002319 Walker B; other site 869215002320 D-loop; other site 869215002321 H-loop/switch region; other site 869215002322 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869215002323 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869215002324 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 869215002325 TM-ABC transporter signature motif; other site 869215002326 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869215002327 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 869215002328 TM-ABC transporter signature motif; other site 869215002331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869215002332 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869215002333 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 869215002334 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 869215002335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215002336 Mg2+ binding site [ion binding]; other site 869215002337 G-X-G motif; other site 869215002338 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 869215002339 anchoring element; other site 869215002340 dimer interface [polypeptide binding]; other site 869215002341 ATP binding site [chemical binding]; other site 869215002342 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 869215002343 active site 869215002344 putative metal-binding site [ion binding]; other site 869215002345 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 869215002346 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 869215002347 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 869215002348 CAP-like domain; other site 869215002349 active site 869215002350 primary dimer interface [polypeptide binding]; other site 869215002351 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869215002352 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 869215002353 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 869215002354 homodimer interface [polypeptide binding]; other site 869215002355 substrate-cofactor binding pocket; other site 869215002356 catalytic residue [active] 869215002357 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 869215002358 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 869215002359 Predicted membrane protein [Function unknown]; Region: COG3819 869215002360 Predicted membrane protein [Function unknown]; Region: COG3817 869215002361 Protein of unknown function (DUF979); Region: DUF979; pfam06166 869215002362 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 869215002363 putative substrate binding pocket [chemical binding]; other site 869215002364 AC domain interface; other site 869215002365 catalytic triad [active] 869215002366 AB domain interface; other site 869215002367 interchain disulfide; other site 869215002368 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 869215002369 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 869215002370 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 869215002371 RNA binding site [nucleotide binding]; other site 869215002372 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 869215002373 RNA binding site [nucleotide binding]; other site 869215002374 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 869215002375 RNA binding site [nucleotide binding]; other site 869215002376 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 869215002377 RNA binding site [nucleotide binding]; other site 869215002379 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 869215002380 GAF domain; Region: GAF_2; pfam13185 869215002381 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 869215002382 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215002383 Walker A motif; other site 869215002384 ATP binding site [chemical binding]; other site 869215002385 Walker B motif; other site 869215002386 arginine finger; other site 869215002387 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 869215002388 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 869215002389 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 869215002390 Walker A/P-loop; other site 869215002391 ATP binding site [chemical binding]; other site 869215002392 Q-loop/lid; other site 869215002393 ABC transporter signature motif; other site 869215002394 Walker B; other site 869215002395 D-loop; other site 869215002396 H-loop/switch region; other site 869215002397 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 869215002398 FeS assembly protein SufD; Region: sufD; TIGR01981 869215002399 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 869215002400 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 869215002401 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869215002402 catalytic residue [active] 869215002403 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 869215002404 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 869215002405 trimerization site [polypeptide binding]; other site 869215002406 active site 869215002407 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 869215002408 FeS assembly protein SufB; Region: sufB; TIGR01980 869215002409 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 869215002410 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 869215002411 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 869215002412 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 869215002413 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869215002414 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869215002415 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 869215002416 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869215002417 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 869215002418 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 869215002419 putative substrate binding site [chemical binding]; other site 869215002420 putative ATP binding site [chemical binding]; other site 869215002421 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 869215002422 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869215002423 active site 869215002424 phosphorylation site [posttranslational modification] 869215002425 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 869215002426 active site 869215002427 P-loop; other site 869215002428 phosphorylation site [posttranslational modification] 869215002429 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 869215002430 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 869215002431 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 869215002432 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869215002433 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 869215002434 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 869215002435 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 869215002436 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869215002437 catalytic residue [active] 869215002438 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 869215002439 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 869215002440 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 869215002441 Ligand Binding Site [chemical binding]; other site 869215002442 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 869215002443 Putative esterase; Region: Esterase; pfam00756 869215002444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 869215002445 Putative esterase; Region: Esterase; pfam00756 869215002447 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 869215002448 HsdM N-terminal domain; Region: HsdM_N; pfam12161 869215002449 Methyltransferase domain; Region: Methyltransf_26; pfam13659 869215002450 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 869215002451 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 869215002452 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 869215002453 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 869215002454 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 869215002455 active site 869215002456 catalytic residues [active] 869215002457 DNA binding site [nucleotide binding] 869215002458 Int/Topo IB signature motif; other site 869215002459 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 869215002460 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 869215002462 Arginine repressor [Transcription]; Region: ArgR; COG1438 869215002463 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869215002464 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869215002465 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 869215002466 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 869215002467 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 869215002468 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 869215002469 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 869215002470 active site 869215002471 PHP Thumb interface [polypeptide binding]; other site 869215002472 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 869215002473 generic binding surface II; other site 869215002474 generic binding surface I; other site 869215002475 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 869215002476 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 869215002477 active site 869215002478 ADP/pyrophosphate binding site [chemical binding]; other site 869215002479 dimerization interface [polypeptide binding]; other site 869215002480 allosteric effector site; other site 869215002481 fructose-1,6-bisphosphate binding site; other site 869215002482 pyruvate kinase; Provisional; Region: PRK05826 869215002483 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 869215002484 domain interfaces; other site 869215002485 active site 869215002487 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 869215002488 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 869215002489 Predicted membrane protein [Function unknown]; Region: COG3689 869215002490 Predicted permeases [General function prediction only]; Region: COG0701 869215002491 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 869215002492 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 869215002493 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 869215002494 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 869215002495 RNA binding site [nucleotide binding]; other site 869215002496 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 869215002497 hypothetical protein; Provisional; Region: PRK04351 869215002498 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 869215002499 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869215002500 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869215002501 Walker A/P-loop; other site 869215002502 ATP binding site [chemical binding]; other site 869215002503 Q-loop/lid; other site 869215002504 ABC transporter signature motif; other site 869215002505 Walker B; other site 869215002506 D-loop; other site 869215002507 H-loop/switch region; other site 869215002508 FtsX-like permease family; Region: FtsX; pfam02687 869215002509 disrupted by IS insertion 869215002510 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 869215002511 Helix-turn-helix domain; Region: HTH_38; pfam13936 869215002512 Integrase core domain; Region: rve; pfam00665 869215002513 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 869215002514 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 869215002515 homodimer interface [polypeptide binding]; other site 869215002516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215002517 catalytic residue [active] 869215002518 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 869215002519 Transposase; Region: DEDD_Tnp_IS110; pfam01548 869215002520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 869215002521 spermidine synthase; Provisional; Region: PRK00811 869215002522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215002523 S-adenosylmethionine binding site [chemical binding]; other site 869215002524 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 869215002525 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 869215002526 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 869215002527 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 869215002528 dimer interface [polypeptide binding]; other site 869215002529 active site 869215002530 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869215002531 catalytic residues [active] 869215002532 substrate binding site [chemical binding]; other site 869215002533 agmatine deiminase; Provisional; Region: PRK13551 869215002534 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 869215002535 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 869215002536 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 869215002537 putative active site; other site 869215002538 catalytic triad [active] 869215002539 putative dimer interface [polypeptide binding]; other site 869215002540 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215002541 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869215002542 active site 869215002543 motif I; other site 869215002544 motif II; other site 869215002545 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215002546 CAAX protease self-immunity; Region: Abi; pfam02517 869215002547 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869215002548 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869215002549 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869215002550 dimerization interface [polypeptide binding]; other site 869215002551 lipoprotein signal peptidase; Provisional; Region: PRK14797 869215002552 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869215002553 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869215002554 RNA binding surface [nucleotide binding]; other site 869215002555 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869215002556 active site 869215002557 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 869215002558 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869215002559 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869215002560 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 869215002561 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 869215002562 nucleotide binding site [chemical binding]; other site 869215002563 homotetrameric interface [polypeptide binding]; other site 869215002564 putative phosphate binding site [ion binding]; other site 869215002565 putative allosteric binding site; other site 869215002566 PUA domain; Region: PUA; pfam01472 869215002567 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 869215002568 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 869215002569 putative catalytic cysteine [active] 869215002570 pyrroline-5-carboxylate reductase; Region: PLN02688 869215002571 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 869215002572 thymidylate kinase; Validated; Region: tmk; PRK00698 869215002573 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 869215002574 TMP-binding site; other site 869215002575 ATP-binding site [chemical binding]; other site 869215002576 DNA polymerase III subunit delta'; Validated; Region: PRK07276 869215002577 DNA polymerase III subunit delta'; Validated; Region: PRK08485 869215002578 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 869215002579 Predicted methyltransferases [General function prediction only]; Region: COG0313 869215002580 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 869215002581 putative SAM binding site [chemical binding]; other site 869215002582 putative homodimer interface [polypeptide binding]; other site 869215002583 Uncharacterized conserved protein [Function unknown]; Region: COG4283 869215002584 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 869215002587 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 869215002588 Glucose inhibited division protein A; Region: GIDA; pfam01134 869215002589 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 869215002590 putative nucleotide binding site [chemical binding]; other site 869215002591 uridine monophosphate binding site [chemical binding]; other site 869215002592 homohexameric interface [polypeptide binding]; other site 869215002593 ribosome recycling factor; Reviewed; Region: frr; PRK00083 869215002594 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 869215002595 hinge region; other site 869215002596 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 869215002597 S1 domain; Region: S1_2; pfam13509 869215002598 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 869215002599 hypothetical protein; Provisional; Region: PRK13672 869215002600 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 869215002601 PhoH-like protein; Region: PhoH; pfam02562 869215002602 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869215002603 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869215002604 Coenzyme A binding pocket [chemical binding]; other site 869215002607 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869215002608 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869215002609 SLBB domain; Region: SLBB; pfam10531 869215002610 comEA protein; Region: comE; TIGR01259 869215002611 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 869215002612 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 869215002613 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 869215002614 Competence protein; Region: Competence; pfam03772 869215002615 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 869215002616 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869215002617 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869215002618 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869215002619 Walker A/P-loop; other site 869215002620 ATP binding site [chemical binding]; other site 869215002621 Q-loop/lid; other site 869215002622 ABC transporter signature motif; other site 869215002623 Walker B; other site 869215002624 D-loop; other site 869215002625 H-loop/switch region; other site 869215002626 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 869215002627 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 869215002628 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 869215002629 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 869215002630 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 869215002631 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 869215002632 23S rRNA binding site [nucleotide binding]; other site 869215002633 L21 binding site [polypeptide binding]; other site 869215002634 L13 binding site [polypeptide binding]; other site 869215002635 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869215002636 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 869215002637 dimer interface [polypeptide binding]; other site 869215002638 active site 869215002639 metal binding site [ion binding]; metal-binding site 869215002640 glutathione binding site [chemical binding]; other site 869215002641 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 869215002642 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 869215002643 FAD binding pocket [chemical binding]; other site 869215002644 FAD binding motif [chemical binding]; other site 869215002645 phosphate binding motif [ion binding]; other site 869215002646 beta-alpha-beta structure motif; other site 869215002647 NAD binding pocket [chemical binding]; other site 869215002648 Iron coordination center [ion binding]; other site 869215002649 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 869215002650 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 869215002651 heterodimer interface [polypeptide binding]; other site 869215002652 active site 869215002653 FMN binding site [chemical binding]; other site 869215002654 homodimer interface [polypeptide binding]; other site 869215002655 substrate binding site [chemical binding]; other site 869215002656 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869215002657 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 869215002658 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 869215002659 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 869215002660 Domain of unknown function (DUF814); Region: DUF814; pfam05670 869215002661 metal-binding heat shock protein; Provisional; Region: PRK00016 869215002662 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 869215002663 GTPase Era; Reviewed; Region: era; PRK00089 869215002664 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 869215002665 G1 box; other site 869215002666 GTP/Mg2+ binding site [chemical binding]; other site 869215002667 Switch I region; other site 869215002668 G2 box; other site 869215002669 Switch II region; other site 869215002670 G3 box; other site 869215002671 G4 box; other site 869215002672 G5 box; other site 869215002673 KH domain; Region: KH_2; pfam07650 869215002674 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 869215002675 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 869215002676 DNA binding site [nucleotide binding] 869215002677 catalytic residue [active] 869215002678 H2TH interface [polypeptide binding]; other site 869215002679 putative catalytic residues [active] 869215002680 turnover-facilitating residue; other site 869215002681 intercalation triad [nucleotide binding]; other site 869215002682 8OG recognition residue [nucleotide binding]; other site 869215002683 putative reading head residues; other site 869215002684 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 869215002685 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 869215002686 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 869215002687 dephospho-CoA kinase; Region: TIGR00152 869215002688 CoA-binding site [chemical binding]; other site 869215002689 ATP-binding [chemical binding]; other site 869215002690 drug efflux system protein MdtG; Provisional; Region: PRK09874 869215002691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869215002692 putative substrate translocation pore; other site 869215002693 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 869215002694 ribonuclease R; Region: RNase_R; TIGR02063 869215002695 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 869215002696 RNB domain; Region: RNB; pfam00773 869215002697 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 869215002698 RNA binding site [nucleotide binding]; other site 869215002699 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 869215002700 SmpB-tmRNA interface; other site 869215002701 tellurite resistance protein TehB; Provisional; Region: PRK12335 869215002702 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 869215002703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215002704 S-adenosylmethionine binding site [chemical binding]; other site 869215002705 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 869215002706 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 869215002707 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 869215002708 active site 869215002709 Zn binding site [ion binding]; other site 869215002710 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 869215002711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215002712 S-adenosylmethionine binding site [chemical binding]; other site 869215002713 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 869215002714 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 869215002718 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869215002719 catalytic core [active] 869215002720 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 869215002721 putative deacylase active site [active] 869215002722 Predicted membrane protein [Function unknown]; Region: COG2035 869215002723 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 869215002724 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 869215002725 active site 869215002726 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 869215002727 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 869215002728 Substrate binding site; other site 869215002729 Mg++ binding site; other site 869215002730 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 869215002731 active site 869215002732 substrate binding site [chemical binding]; other site 869215002733 CoA binding site [chemical binding]; other site 869215002734 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 869215002735 dimer interface [polypeptide binding]; other site 869215002736 ADP-ribose binding site [chemical binding]; other site 869215002737 active site 869215002738 nudix motif; other site 869215002739 metal binding site [ion binding]; metal-binding site 869215002740 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 869215002741 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 869215002742 MarR family; Region: MarR_2; cl17246 869215002743 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 869215002744 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869215002745 active site 869215002746 catalytic site [active] 869215002747 substrate binding site [chemical binding]; other site 869215002748 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 869215002749 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 869215002750 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 869215002751 putative active site [active] 869215002752 catalytic site [active] 869215002753 putative metal binding site [ion binding]; other site 869215002755 Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases; Region: TM_EGFR-like; cl17045 869215002756 dimer interface [polypeptide binding]; other site 869215002757 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 869215002758 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 869215002759 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 869215002760 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869215002761 catalytic residues [active] 869215002762 amino acid transporter; Region: 2A0306; TIGR00909 869215002763 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 869215002764 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869215002765 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 869215002766 metal binding site [ion binding]; metal-binding site 869215002767 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 869215002768 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869215002769 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869215002770 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869215002771 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 869215002772 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869215002773 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869215002774 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869215002775 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869215002778 pseudogene structure indicated by variation in homologue lengths and Frameplot 869215002779 peptidase T; Region: peptidase-T; TIGR01882 869215002780 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 869215002781 metal binding site [ion binding]; metal-binding site 869215002782 dimer interface [polypeptide binding]; other site 869215002783 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 869215002784 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 869215002785 C-terminal domain interface [polypeptide binding]; other site 869215002786 active site 869215002787 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 869215002788 active site 869215002789 N-terminal domain interface [polypeptide binding]; other site 869215002790 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 869215002791 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 869215002792 Predicted membrane protein [Function unknown]; Region: COG2246 869215002793 GtrA-like protein; Region: GtrA; pfam04138 869215002794 Predicted membrane protein [Function unknown]; Region: COG4708 869215002795 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 869215002796 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 869215002797 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 869215002798 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 869215002799 dimer interface [polypeptide binding]; other site 869215002800 active site 869215002801 catalytic residue [active] 869215002802 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 869215002803 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 869215002804 trmE is a tRNA modification GTPase; Region: trmE; cd04164 869215002805 G1 box; other site 869215002806 GTP/Mg2+ binding site [chemical binding]; other site 869215002807 Switch I region; other site 869215002808 G2 box; other site 869215002809 Switch II region; other site 869215002810 G3 box; other site 869215002811 G4 box; other site 869215002812 G5 box; other site 869215002813 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 869215002814 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 869215002815 active site 1 [active] 869215002816 dimer interface [polypeptide binding]; other site 869215002817 hexamer interface [polypeptide binding]; other site 869215002818 active site 2 [active] 869215002819 thymidine kinase; Provisional; Region: PRK04296 869215002820 peptide chain release factor 1; Validated; Region: prfA; PRK00591 869215002821 This domain is found in peptide chain release factors; Region: PCRF; smart00937 869215002822 RF-1 domain; Region: RF-1; pfam00472 869215002823 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 869215002824 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215002825 S-adenosylmethionine binding site [chemical binding]; other site 869215002826 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 869215002827 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869215002828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869215002829 Coenzyme A binding pocket [chemical binding]; other site 869215002830 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 869215002831 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 869215002832 dimer interface [polypeptide binding]; other site 869215002833 active site 869215002834 glycine-pyridoxal phosphate binding site [chemical binding]; other site 869215002835 folate binding site [chemical binding]; other site 869215002836 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 869215002837 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 869215002838 Lysozyme-like; Region: Lysozyme_like; pfam13702 869215002839 Predicted secreted protein [Function unknown]; Region: COG4086 869215002840 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 869215002841 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 869215002842 TRAM domain; Region: TRAM; cl01282 869215002843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215002844 S-adenosylmethionine binding site [chemical binding]; other site 869215002845 Predicted transcriptional regulator [Transcription]; Region: COG3655 869215002846 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 869215002847 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 869215002848 siderophore binding site; other site 869215002849 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 869215002850 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869215002851 ABC-ATPase subunit interface; other site 869215002852 dimer interface [polypeptide binding]; other site 869215002853 putative PBP binding regions; other site 869215002854 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869215002855 ABC-ATPase subunit interface; other site 869215002856 dimer interface [polypeptide binding]; other site 869215002857 putative PBP binding regions; other site 869215002858 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 869215002859 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869215002860 Walker A/P-loop; other site 869215002861 ATP binding site [chemical binding]; other site 869215002862 Q-loop/lid; other site 869215002863 ABC transporter signature motif; other site 869215002864 Walker B; other site 869215002865 D-loop; other site 869215002866 H-loop/switch region; other site 869215002868 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 869215002870 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 869215002871 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 869215002872 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 869215002873 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 869215002874 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 869215002875 homodimer interface [polypeptide binding]; other site 869215002876 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 869215002877 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 869215002878 active site 869215002879 homodimer interface [polypeptide binding]; other site 869215002880 catalytic site [active] 869215002881 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869215002882 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215002883 non-specific DNA binding site [nucleotide binding]; other site 869215002884 salt bridge; other site 869215002885 sequence-specific DNA binding site [nucleotide binding]; other site 869215002886 Zeta toxin; Region: Zeta_toxin; pfam06414 869215002887 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 869215002888 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 869215002889 AAA domain; Region: AAA_21; pfam13304 869215002890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215002891 ABC transporter signature motif; other site 869215002892 Walker B; other site 869215002893 D-loop; other site 869215002894 H-loop/switch region; other site 869215002895 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 869215002897 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 869215002898 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 869215002899 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869215002900 Enolase [Carbohydrate transport and metabolism]; Region: Eno; COG0148 869215002901 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 869215002902 metal binding site [ion binding]; metal-binding site 869215002903 substrate binding pocket [chemical binding]; other site 869215002904 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 869215002905 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 869215002906 homodimer interface [polypeptide binding]; other site 869215002907 substrate-cofactor binding pocket; other site 869215002908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215002909 catalytic residue [active] 869215002910 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869215002911 TPP-binding site [chemical binding]; other site 869215002912 dimer interface [polypeptide binding]; other site 869215002913 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 869215002914 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869215002915 PYR/PP interface [polypeptide binding]; other site 869215002916 dimer interface [polypeptide binding]; other site 869215002917 TPP binding site [chemical binding]; other site 869215002918 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869215002919 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 869215002920 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 869215002921 inhibitor-cofactor binding pocket; inhibition site 869215002922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215002923 catalytic residue [active] 869215002924 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 869215002925 active site 869215002926 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 869215002927 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cd03174 869215002928 active site 869215002929 catalytic residues [active] 869215002930 metal binding site [ion binding]; metal-binding site 869215002931 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 869215002932 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 869215002933 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 869215002934 tetramer interface [polypeptide binding]; other site 869215002935 active site 869215002936 Mg2+/Mn2+ binding site [ion binding]; other site 869215002937 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869215002938 phosphonopyruvate decarboxylase; Region: Ppyr-DeCO2ase; TIGR03297 869215002939 PYR/PP interface [polypeptide binding]; other site 869215002940 dimer interface [polypeptide binding]; other site 869215002941 TPP binding site [chemical binding]; other site 869215002942 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 869215002943 TPP-binding site [chemical binding]; other site 869215002944 hypothetical protein; Validated; Region: PRK07080 869215002945 acyl carrier protein; Provisional; Region: PRK07081 869215002946 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 869215002947 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 869215002948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215002949 Walker A/P-loop; other site 869215002950 ATP binding site [chemical binding]; other site 869215002951 Q-loop/lid; other site 869215002952 ABC transporter signature motif; other site 869215002953 Walker B; other site 869215002954 D-loop; other site 869215002955 H-loop/switch region; other site 869215002956 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 869215002957 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 869215002958 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 869215002960 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 869215002961 conserved cys residue [active] 869215002962 Phosphotransferase enzyme family; Region: APH; pfam01636 869215002963 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 869215002964 active site 869215002965 ATP binding site [chemical binding]; other site 869215002966 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 869215002967 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 869215002968 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 869215002969 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 869215002970 zinc binding site [ion binding]; other site 869215002971 putative ligand binding site [chemical binding]; other site 869215002972 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869215002973 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 869215002974 TM-ABC transporter signature motif; other site 869215002975 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 869215002976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215002977 Walker A/P-loop; other site 869215002978 ATP binding site [chemical binding]; other site 869215002979 Q-loop/lid; other site 869215002980 ABC transporter signature motif; other site 869215002981 Walker B; other site 869215002982 D-loop; other site 869215002983 H-loop/switch region; other site 869215002984 DNA primase; Validated; Region: dnaG; PRK05667 869215002985 CHC2 zinc finger; Region: zf-CHC2; pfam01807 869215002986 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 869215002987 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 869215002988 active site 869215002989 metal binding site [ion binding]; metal-binding site 869215002990 interdomain interaction site; other site 869215002991 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 869215002992 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 869215002993 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 869215002994 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869215002995 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869215002996 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869215002997 DNA binding residues [nucleotide binding] 869215002998 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 869215002999 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869215003000 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 869215003001 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869215003002 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 869215003003 putative ADP-binding pocket [chemical binding]; other site 869215003004 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 869215003005 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 869215003006 GTPase CgtA; Reviewed; Region: obgE; PRK12297 869215003007 GTP1/OBG; Region: GTP1_OBG; pfam01018 869215003008 Obg GTPase; Region: Obg; cd01898 869215003009 G1 box; other site 869215003010 GTP/Mg2+ binding site [chemical binding]; other site 869215003011 Switch I region; other site 869215003012 G2 box; other site 869215003013 G3 box; other site 869215003014 Switch II region; other site 869215003015 G4 box; other site 869215003016 G5 box; other site 869215003017 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 869215003018 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 869215003019 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 869215003020 hinge; other site 869215003021 active site 869215003022 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869215003023 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869215003024 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 869215003025 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869215003026 DNA-binding site [nucleotide binding]; DNA binding site 869215003027 DRTGG domain; Region: DRTGG; pfam07085 869215003028 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 869215003029 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 869215003030 active site 2 [active] 869215003031 active site 1 [active] 869215003032 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 869215003033 active site 869215003035 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 869215003036 Part of AAA domain; Region: AAA_19; pfam13245 869215003037 Family description; Region: UvrD_C_2; pfam13538 869215003038 hypothetical protein; Reviewed; Region: PRK00024 869215003039 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 869215003040 MPN+ (JAMM) motif; other site 869215003041 Zinc-binding site [ion binding]; other site 869215003042 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 869215003043 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 869215003044 catalytic triad [active] 869215003045 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 869215003046 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 869215003047 CoA binding domain; Region: CoA_binding; pfam02629 869215003048 Putative amino acid metabolism; Region: DUF1831; pfam08866 869215003049 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 869215003050 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 869215003051 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869215003052 catalytic residue [active] 869215003053 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 869215003054 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 869215003055 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869215003056 active site 869215003057 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 869215003058 putative active site [active] 869215003059 putative metal binding residues [ion binding]; other site 869215003060 signature motif; other site 869215003061 putative triphosphate binding site [ion binding]; other site 869215003062 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869215003063 synthetase active site [active] 869215003064 NTP binding site [chemical binding]; other site 869215003065 metal binding site [ion binding]; metal-binding site 869215003066 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 869215003067 ATP-NAD kinase; Region: NAD_kinase; pfam01513 869215003068 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869215003069 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 869215003070 RNA binding surface [nucleotide binding]; other site 869215003071 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869215003072 active site 869215003073 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 869215003075 hypothetical protein; Validated; Region: PRK00153 869215003077 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 869215003078 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 869215003079 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 869215003080 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 869215003081 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 869215003082 active site 869215003083 Riboflavin kinase; Region: Flavokinase; smart00904 869215003084 Uncharacterized conserved protein [Function unknown]; Region: COG1284 869215003085 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869215003086 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869215003087 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 869215003088 EDD domain protein, DegV family; Region: DegV; TIGR00762 869215003089 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 869215003090 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 869215003091 IHF dimer interface [polypeptide binding]; other site 869215003092 IHF - DNA interface [nucleotide binding]; other site 869215003093 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869215003094 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869215003095 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869215003096 ABC transporter; Region: ABC_tran_2; pfam12848 869215003097 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869215003098 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215003099 non-specific DNA binding site [nucleotide binding]; other site 869215003100 salt bridge; other site 869215003101 sequence-specific DNA binding site [nucleotide binding]; other site 869215003102 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869215003103 H+ Antiporter protein; Region: 2A0121; TIGR00900 869215003104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869215003105 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 869215003106 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 869215003107 nucleotide binding pocket [chemical binding]; other site 869215003108 K-X-D-G motif; other site 869215003109 catalytic site [active] 869215003110 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 869215003111 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 869215003112 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 869215003113 Dimer interface [polypeptide binding]; other site 869215003114 BRCT sequence motif; other site 869215003115 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 869215003116 pullulanase, type I; Region: pulA_typeI; TIGR02104 869215003117 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 869215003118 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 869215003119 Ca binding site [ion binding]; other site 869215003120 active site 869215003121 catalytic site [active] 869215003122 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 869215003123 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 869215003124 tetrameric interface [polypeptide binding]; other site 869215003125 activator binding site; other site 869215003126 NADP binding site [chemical binding]; other site 869215003127 substrate binding site [chemical binding]; other site 869215003128 catalytic residues [active] 869215003129 glycogen branching enzyme; Provisional; Region: PRK12313 869215003130 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 869215003131 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 869215003132 active site 869215003133 catalytic site [active] 869215003134 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 869215003135 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 869215003136 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 869215003137 ligand binding site; other site 869215003138 oligomer interface; other site 869215003139 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 869215003140 dimer interface [polypeptide binding]; other site 869215003141 N-terminal domain interface [polypeptide binding]; other site 869215003142 sulfate 1 binding site; other site 869215003143 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 869215003144 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869215003145 active site 869215003146 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 869215003147 dimer interface [polypeptide binding]; other site 869215003148 N-terminal domain interface [polypeptide binding]; other site 869215003149 sulfate 1 binding site; other site 869215003150 glycogen synthase; Provisional; Region: glgA; PRK00654 869215003151 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 869215003152 ADP-binding pocket [chemical binding]; other site 869215003153 homodimer interface [polypeptide binding]; other site 869215003156 Uncharacterized conserved protein [Function unknown]; Region: COG5506 869215003157 enolase; Provisional; Region: eno; PRK00077 869215003158 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 869215003159 dimer interface [polypeptide binding]; other site 869215003160 metal binding site [ion binding]; metal-binding site 869215003161 substrate binding pocket [chemical binding]; other site 869215003164 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 869215003165 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 869215003166 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 869215003167 Part of AAA domain; Region: AAA_19; pfam13245 869215003168 Family description; Region: UvrD_C_2; pfam13538 869215003169 Family description; Region: UvrD_C_2; pfam13538 869215003170 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 869215003171 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869215003172 G5 domain; Region: G5; pfam07501 869215003173 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 869215003174 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 869215003175 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 869215003176 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 869215003177 GTP/Mg2+ binding site [chemical binding]; other site 869215003178 G4 box; other site 869215003179 G5 box; other site 869215003180 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 869215003181 G1 box; other site 869215003182 G1 box; other site 869215003183 GTP/Mg2+ binding site [chemical binding]; other site 869215003184 Switch I region; other site 869215003185 G2 box; other site 869215003186 G2 box; other site 869215003187 G3 box; other site 869215003188 G3 box; other site 869215003189 Switch II region; other site 869215003190 Switch II region; other site 869215003191 G5 box; other site 869215003192 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 869215003193 RNA/DNA hybrid binding site [nucleotide binding]; other site 869215003194 active site 869215003195 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 869215003196 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 869215003197 Cl- selectivity filter; other site 869215003198 Cl- binding residues [ion binding]; other site 869215003199 pore gating glutamate residue; other site 869215003200 dimer interface [polypeptide binding]; other site 869215003201 H+/Cl- coupling transport residue; other site 869215003202 TrkA-C domain; Region: TrkA_C; pfam02080 869215003203 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 869215003204 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869215003205 active site 869215003206 DNA binding site [nucleotide binding] 869215003207 Int/Topo IB signature motif; other site 869215003208 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 869215003209 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 869215003210 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 869215003211 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869215003212 E3 interaction surface; other site 869215003213 lipoyl attachment site [posttranslational modification]; other site 869215003214 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 869215003215 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 869215003216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869215003217 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869215003218 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 869215003219 e3 binding domain; Region: E3_binding; pfam02817 869215003220 e3 binding domain; Region: E3_binding; pfam02817 869215003221 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 869215003222 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 869215003223 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 869215003224 alpha subunit interface [polypeptide binding]; other site 869215003225 TPP binding site [chemical binding]; other site 869215003226 heterodimer interface [polypeptide binding]; other site 869215003227 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869215003228 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 869215003229 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 869215003230 tetramer interface [polypeptide binding]; other site 869215003231 TPP-binding site [chemical binding]; other site 869215003232 heterodimer interface [polypeptide binding]; other site 869215003233 phosphorylation loop region [posttranslational modification] 869215003234 multidrug efflux protein; Reviewed; Region: PRK01766 869215003235 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 869215003236 cation binding site [ion binding]; other site 869215003237 dihydroorotase; Validated; Region: pyrC; PRK09357 869215003238 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 869215003239 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 869215003240 active site 869215003241 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 869215003242 putative active site [active] 869215003243 nucleotide binding site [chemical binding]; other site 869215003244 nudix motif; other site 869215003245 putative metal binding site [ion binding]; other site 869215003246 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 869215003247 ligand binding site [chemical binding]; other site 869215003248 active site 869215003249 UGI interface [polypeptide binding]; other site 869215003250 catalytic site [active] 869215003251 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 869215003252 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215003253 motif II; other site 869215003254 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 869215003255 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 869215003256 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869215003257 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869215003258 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869215003259 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 869215003260 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 869215003261 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869215003262 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869215003263 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 869215003264 dimerization domain swap beta strand [polypeptide binding]; other site 869215003265 regulatory protein interface [polypeptide binding]; other site 869215003266 active site 869215003267 regulatory phosphorylation site [posttranslational modification]; other site 869215003268 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 869215003269 catalytic residues [active] 869215003270 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 869215003271 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 869215003272 Class I ribonucleotide reductase; Region: RNR_I; cd01679 869215003273 active site 869215003274 dimer interface [polypeptide binding]; other site 869215003275 catalytic residues [active] 869215003276 effector binding site; other site 869215003277 R2 peptide binding site; other site 869215003278 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 869215003279 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 869215003280 dimer interface [polypeptide binding]; other site 869215003281 putative radical transfer pathway; other site 869215003282 diiron center [ion binding]; other site 869215003283 tyrosyl radical; other site 869215003284 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869215003285 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 869215003286 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869215003287 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 869215003288 beta-galactosidase; Region: BGL; TIGR03356 869215003289 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 869215003290 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 869215003291 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 869215003292 active site 869215003293 P-loop; other site 869215003294 phosphorylation site [posttranslational modification] 869215003295 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869215003296 methionine cluster; other site 869215003297 active site 869215003298 phosphorylation site [posttranslational modification] 869215003299 metal binding site [ion binding]; metal-binding site 869215003300 CAT RNA binding domain; Region: CAT_RBD; smart01061 869215003301 transcriptional antiterminator BglG; Provisional; Region: PRK09772 869215003302 PRD domain; Region: PRD; pfam00874 869215003303 PRD domain; Region: PRD; pfam00874 869215003304 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 869215003305 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 869215003306 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 869215003307 putative substrate binding site [chemical binding]; other site 869215003308 putative ATP binding site [chemical binding]; other site 869215003309 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 869215003310 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 869215003311 N-terminal truncation due to IS insertion 869215003313 C-terminal truncation due to IS insertion 869215003314 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869215003315 active site 869215003316 phosphorylation site [posttranslational modification] 869215003317 GTP-binding protein LepA; Provisional; Region: PRK05433 869215003318 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 869215003319 G1 box; other site 869215003320 putative GEF interaction site [polypeptide binding]; other site 869215003321 GTP/Mg2+ binding site [chemical binding]; other site 869215003322 Switch I region; other site 869215003323 G2 box; other site 869215003324 G3 box; other site 869215003325 Switch II region; other site 869215003326 G4 box; other site 869215003327 G5 box; other site 869215003328 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 869215003329 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 869215003330 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 869215003331 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 869215003332 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869215003333 active site 869215003334 metal binding site [ion binding]; metal-binding site 869215003335 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 869215003336 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 869215003337 Walker A/P-loop; other site 869215003338 ATP binding site [chemical binding]; other site 869215003339 Q-loop/lid; other site 869215003340 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 869215003341 ABC transporter signature motif; other site 869215003342 Walker B; other site 869215003343 D-loop; other site 869215003344 H-loop/switch region; other site 869215003345 Arginine repressor [Transcription]; Region: ArgR; COG1438 869215003346 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869215003347 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869215003348 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 869215003349 S4 RNA-binding domain; Region: S4; smart00363 869215003350 RNA binding surface [nucleotide binding]; other site 869215003351 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 869215003352 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 869215003353 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 869215003354 substrate binding pocket [chemical binding]; other site 869215003355 chain length determination region; other site 869215003356 substrate-Mg2+ binding site; other site 869215003357 catalytic residues [active] 869215003358 aspartate-rich region 1; other site 869215003359 active site lid residues [active] 869215003360 aspartate-rich region 2; other site 869215003361 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 869215003362 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 869215003363 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 869215003364 generic binding surface II; other site 869215003365 generic binding surface I; other site 869215003366 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 869215003367 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 869215003368 Sugar specificity; other site 869215003369 Pyrimidine base specificity; other site 869215003370 ATP-binding site [chemical binding]; other site 869215003371 Enterocin A Immunity; Region: EntA_Immun; pfam08951 869215003372 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 869215003373 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 869215003374 RNA binding site [nucleotide binding]; other site 869215003375 active site 869215003376 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 869215003377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 869215003378 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 869215003380 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 869215003381 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 869215003382 active site 869215003383 catalytic site [active] 869215003384 DNA gyrase subunit A; Validated; Region: PRK05560 869215003385 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 869215003386 CAP-like domain; other site 869215003387 active site 869215003388 primary dimer interface [polypeptide binding]; other site 869215003389 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869215003390 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869215003391 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869215003392 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869215003393 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869215003394 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869215003395 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 869215003396 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 869215003397 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869215003398 NAD binding site [chemical binding]; other site 869215003399 dimer interface [polypeptide binding]; other site 869215003400 substrate binding site [chemical binding]; other site 869215003401 Ion channel; Region: Ion_trans_2; pfam07885 869215003402 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 869215003403 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 869215003404 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 869215003405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 869215003406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869215003407 putative active site [active] 869215003408 heme pocket [chemical binding]; other site 869215003409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869215003410 dimer interface [polypeptide binding]; other site 869215003411 phosphorylation site [posttranslational modification] 869215003412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215003413 ATP binding site [chemical binding]; other site 869215003414 Mg2+ binding site [ion binding]; other site 869215003415 G-X-G motif; other site 869215003416 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869215003417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869215003418 active site 869215003419 phosphorylation site [posttranslational modification] 869215003420 intermolecular recognition site; other site 869215003421 dimerization interface [polypeptide binding]; other site 869215003422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869215003423 DNA binding site [nucleotide binding] 869215003424 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 869215003425 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869215003426 minor groove reading motif; other site 869215003427 helix-hairpin-helix signature motif; other site 869215003428 substrate binding pocket [chemical binding]; other site 869215003429 active site 869215003430 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 869215003431 DNA binding and oxoG recognition site [nucleotide binding] 869215003432 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 869215003433 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 869215003434 Potassium binding sites [ion binding]; other site 869215003435 Cesium cation binding sites [ion binding]; other site 869215003436 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 869215003437 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 869215003438 Flavoprotein; Region: Flavoprotein; pfam02441 869215003439 Predicted membrane protein [Function unknown]; Region: COG4684 869215003440 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 869215003441 HTH domain; Region: HTH_11; pfam08279 869215003442 3H domain; Region: 3H; pfam02829 869215003443 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 869215003444 putative active site [active] 869215003445 nucleotide binding site [chemical binding]; other site 869215003446 nudix motif; other site 869215003447 putative metal binding site [ion binding]; other site 869215003448 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869215003449 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869215003450 Coenzyme A binding pocket [chemical binding]; other site 869215003451 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869215003452 excinuclease ABC subunit B; Provisional; Region: PRK05298 869215003453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869215003454 ATP binding site [chemical binding]; other site 869215003455 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869215003456 nucleotide binding region [chemical binding]; other site 869215003457 ATP-binding site [chemical binding]; other site 869215003458 Ultra-violet resistance protein B; Region: UvrB; pfam12344 869215003459 UvrB/uvrC motif; Region: UVR; pfam02151 869215003460 CAAX protease self-immunity; Region: Abi; pfam02517 869215003461 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869215003462 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869215003463 substrate binding pocket [chemical binding]; other site 869215003464 membrane-bound complex binding site; other site 869215003465 hinge residues; other site 869215003466 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869215003467 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869215003468 substrate binding pocket [chemical binding]; other site 869215003469 membrane-bound complex binding site; other site 869215003470 hinge residues; other site 869215003471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215003472 dimer interface [polypeptide binding]; other site 869215003473 conserved gate region; other site 869215003474 putative PBP binding loops; other site 869215003475 ABC-ATPase subunit interface; other site 869215003476 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869215003477 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869215003478 Walker A/P-loop; other site 869215003479 ATP binding site [chemical binding]; other site 869215003480 Q-loop/lid; other site 869215003481 ABC transporter signature motif; other site 869215003482 Walker B; other site 869215003483 D-loop; other site 869215003484 H-loop/switch region; other site 869215003485 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 869215003486 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 869215003487 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 869215003488 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 869215003489 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 869215003490 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 869215003491 P loop; other site 869215003492 GTP binding site [chemical binding]; other site 869215003493 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869215003494 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215003495 motif II; other site 869215003496 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 869215003497 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869215003498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215003499 active site 869215003500 motif I; other site 869215003501 motif II; other site 869215003502 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 869215003503 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 869215003504 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 869215003505 Walker A/P-loop; other site 869215003506 ATP binding site [chemical binding]; other site 869215003507 Q-loop/lid; other site 869215003508 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 869215003509 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 869215003510 ABC transporter signature motif; other site 869215003511 Walker B; other site 869215003512 D-loop; other site 869215003513 H-loop/switch region; other site 869215003514 ribonuclease III; Reviewed; Region: rnc; PRK00102 869215003515 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 869215003516 dimerization interface [polypeptide binding]; other site 869215003517 active site 869215003518 metal binding site [ion binding]; metal-binding site 869215003519 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 869215003520 dsRNA binding site [nucleotide binding]; other site 869215003521 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 869215003522 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869215003523 active site 869215003524 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 869215003525 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 869215003526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215003527 Walker A motif; other site 869215003528 ATP binding site [chemical binding]; other site 869215003529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 869215003531 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 869215003532 substrate binding site [chemical binding]; other site 869215003533 Predicted membrane protein [Function unknown]; Region: COG3326 869215003536 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 869215003537 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 869215003538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 869215003539 DNA topoisomerase I; Validated; Region: PRK05582 869215003540 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 869215003541 active site 869215003542 interdomain interaction site; other site 869215003543 putative metal-binding site [ion binding]; other site 869215003544 nucleotide binding site [chemical binding]; other site 869215003545 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 869215003546 domain I; other site 869215003547 DNA binding groove [nucleotide binding] 869215003548 phosphate binding site [ion binding]; other site 869215003549 domain II; other site 869215003550 domain III; other site 869215003551 nucleotide binding site [chemical binding]; other site 869215003552 catalytic site [active] 869215003553 domain IV; other site 869215003554 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869215003555 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869215003556 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 869215003557 Predicted membrane protein [Function unknown]; Region: COG1808 869215003558 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 869215003559 DNA protecting protein DprA; Region: dprA; TIGR00732 869215003560 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 869215003561 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 869215003562 active site 869215003563 metal-binding site 869215003564 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 869215003565 Phosphotransferase enzyme family; Region: APH; pfam01636 869215003566 active site 869215003567 substrate binding site [chemical binding]; other site 869215003568 ATP binding site [chemical binding]; other site 869215003569 dimer interface [polypeptide binding]; other site 869215003570 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 869215003571 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869215003572 putative NAD(P) binding site [chemical binding]; other site 869215003573 putative catalytic Zn binding site [ion binding]; other site 869215003574 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 869215003575 substrate binding site; other site 869215003576 dimer interface; other site 869215003577 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869215003578 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 869215003579 LicD family; Region: LicD; cl01378 869215003580 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 869215003581 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 869215003582 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869215003583 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869215003584 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 869215003585 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869215003586 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869215003587 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 869215003588 IMP binding site; other site 869215003589 dimer interface [polypeptide binding]; other site 869215003590 interdomain contacts; other site 869215003591 partial ornithine binding site; other site 869215003592 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 869215003593 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 869215003594 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 869215003595 catalytic site [active] 869215003596 subunit interface [polypeptide binding]; other site 869215003597 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 869215003598 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869215003599 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869215003600 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 869215003601 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869215003602 active site 869215003603 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 869215003604 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869215003605 minor groove reading motif; other site 869215003606 helix-hairpin-helix signature motif; other site 869215003607 substrate binding pocket [chemical binding]; other site 869215003608 active site 869215003609 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 869215003610 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869215003611 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869215003612 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869215003613 heat shock protein HtpX; Provisional; Region: PRK04897 869215003614 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 869215003615 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 869215003616 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215003617 S-adenosylmethionine binding site [chemical binding]; other site 869215003618 uracil transporter; Provisional; Region: PRK10720 869215003619 signal recognition particle protein; Provisional; Region: PRK10867 869215003620 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 869215003621 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 869215003622 P loop; other site 869215003623 GTP binding site [chemical binding]; other site 869215003624 Signal peptide binding domain; Region: SRP_SPB; pfam02978 869215003625 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 869215003626 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 869215003627 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 869215003628 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 869215003629 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869215003630 Zn2+ binding site [ion binding]; other site 869215003631 Mg2+ binding site [ion binding]; other site 869215003632 sugar phosphate phosphatase; Provisional; Region: PRK10513 869215003633 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215003634 active site 869215003635 motif I; other site 869215003636 motif II; other site 869215003637 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215003638 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 869215003639 camphor resistance protein CrcB; Provisional; Region: PRK14229 869215003640 camphor resistance protein CrcB; Provisional; Region: PRK14221 869215003641 hypothetical protein; Provisional; Region: PRK07248 869215003642 flavodoxin; Validated; Region: PRK07308 869215003643 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 869215003644 DHH family; Region: DHH; pfam01368 869215003645 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 869215003648 glutamate dehydrogenase; Provisional; Region: PRK09414 869215003649 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 869215003650 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 869215003651 NAD(P) binding site [chemical binding]; other site 869215003657 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869215003658 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869215003659 Walker A/P-loop; other site 869215003660 ATP binding site [chemical binding]; other site 869215003661 Q-loop/lid; other site 869215003662 ABC transporter signature motif; other site 869215003663 Walker B; other site 869215003664 D-loop; other site 869215003665 H-loop/switch region; other site 869215003669 CAAX protease self-immunity; Region: Abi; pfam02517 869215003670 Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393 869215003671 ArsC family; Region: ArsC; pfam03960 869215003672 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 869215003673 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 869215003674 core dimer interface [polypeptide binding]; other site 869215003675 L10 interface [polypeptide binding]; other site 869215003676 L11 interface [polypeptide binding]; other site 869215003677 putative EF-Tu interaction site [polypeptide binding]; other site 869215003678 putative EF-G interaction site [polypeptide binding]; other site 869215003679 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 869215003680 23S rRNA interface [nucleotide binding]; other site 869215003681 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 869215003682 chlorohydrolase; Validated; Region: PRK06687 869215003683 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 869215003684 active site 869215003685 putative substrate binding pocket [chemical binding]; other site 869215003686 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869215003687 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869215003688 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 869215003689 Walker A/P-loop; other site 869215003690 ATP binding site [chemical binding]; other site 869215003691 Q-loop/lid; other site 869215003692 ABC transporter signature motif; other site 869215003693 Walker B; other site 869215003694 D-loop; other site 869215003695 H-loop/switch region; other site 869215003696 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869215003697 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869215003698 APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination; Region: APC10-like; cl02148 869215003699 putative ligand binding site [chemical binding]; other site 869215003700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215003701 Walker A/P-loop; other site 869215003702 ATP binding site [chemical binding]; other site 869215003703 Q-loop/lid; other site 869215003704 ABC transporter signature motif; other site 869215003705 Walker B; other site 869215003706 D-loop; other site 869215003707 H-loop/switch region; other site 869215003708 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 869215003709 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 869215003710 SelR domain; Region: SelR; pfam01641 869215003711 homoserine kinase; Provisional; Region: PRK01212 869215003712 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869215003713 homoserine dehydrogenase; Provisional; Region: PRK06349 869215003714 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 869215003715 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 869215003716 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 869215003717 adaptor protein; Provisional; Region: PRK02315 869215003718 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 869215003719 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 869215003720 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869215003721 active site 869215003722 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869215003723 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 869215003724 putative ADP-binding pocket [chemical binding]; other site 869215003725 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 869215003726 Transcriptional regulator [Transcription]; Region: LytR; COG1316 869215003727 prephenate dehydratase; Provisional; Region: PRK11898 869215003728 Prephenate dehydratase; Region: PDT; pfam00800 869215003729 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 869215003730 putative L-Phe binding site [chemical binding]; other site 869215003731 shikimate kinase; Reviewed; Region: aroK; PRK00131 869215003732 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 869215003733 ADP binding site [chemical binding]; other site 869215003734 magnesium binding site [ion binding]; other site 869215003735 putative shikimate binding site; other site 869215003736 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 869215003737 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 869215003738 hinge; other site 869215003739 active site 869215003740 hypothetical protein; Provisional; Region: PRK13676 869215003741 prephenate dehydrogenase; Validated; Region: PRK06545 869215003742 prephenate dehydrogenase; Validated; Region: PRK08507 869215003743 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 869215003744 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 869215003745 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 869215003746 Tetramer interface [polypeptide binding]; other site 869215003747 active site 869215003748 FMN-binding site [chemical binding]; other site 869215003749 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 869215003750 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 869215003751 active site 869215003752 dimer interface [polypeptide binding]; other site 869215003753 metal binding site [ion binding]; metal-binding site 869215003754 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 869215003755 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 869215003756 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 869215003757 shikimate binding site; other site 869215003758 NAD(P) binding site [chemical binding]; other site 869215003759 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 869215003760 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 869215003761 active site 869215003762 catalytic residue [active] 869215003763 dimer interface [polypeptide binding]; other site 869215003764 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 869215003765 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 869215003766 putative RNA binding site [nucleotide binding]; other site 869215003767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215003769 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 869215003770 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869215003771 Walker A/P-loop; other site 869215003772 ATP binding site [chemical binding]; other site 869215003773 Q-loop/lid; other site 869215003774 ABC transporter signature motif; other site 869215003775 Walker B; other site 869215003776 D-loop; other site 869215003777 H-loop/switch region; other site 869215003778 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 869215003779 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 869215003780 active site 869215003781 Na/Ca binding site [ion binding]; other site 869215003782 catalytic site [active] 869215003783 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 869215003784 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 869215003785 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 869215003786 motif 1; other site 869215003787 active site 869215003788 motif 2; other site 869215003789 motif 3; other site 869215003790 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 869215003791 DHHA1 domain; Region: DHHA1; pfam02272 869215003792 Uncharacterized conserved protein [Function unknown]; Region: COG4894 869215003793 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 869215003794 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 869215003795 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869215003796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215003797 dimer interface [polypeptide binding]; other site 869215003798 conserved gate region; other site 869215003799 putative PBP binding loops; other site 869215003800 ABC-ATPase subunit interface; other site 869215003801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215003802 dimer interface [polypeptide binding]; other site 869215003803 conserved gate region; other site 869215003804 putative PBP binding loops; other site 869215003805 ABC-ATPase subunit interface; other site 869215003806 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869215003807 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 869215003808 Walker A/P-loop; other site 869215003809 ATP binding site [chemical binding]; other site 869215003810 Q-loop/lid; other site 869215003811 ABC transporter signature motif; other site 869215003812 Walker B; other site 869215003813 D-loop; other site 869215003814 H-loop/switch region; other site 869215003815 TOBE domain; Region: TOBE_2; pfam08402 869215003816 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 869215003817 FAD binding domain; Region: FAD_binding_4; pfam01565 869215003818 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 869215003820 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 869215003821 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 869215003822 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869215003823 DNA-binding site [nucleotide binding]; DNA binding site 869215003824 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869215003825 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215003826 homodimer interface [polypeptide binding]; other site 869215003827 catalytic residue [active] 869215003828 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869215003829 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869215003830 substrate binding pocket [chemical binding]; other site 869215003831 membrane-bound complex binding site; other site 869215003832 hinge residues; other site 869215003833 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 869215003834 PhoU domain; Region: PhoU; pfam01895 869215003835 PhoU domain; Region: PhoU; pfam01895 869215003836 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 869215003837 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869215003838 Walker A/P-loop; other site 869215003839 ATP binding site [chemical binding]; other site 869215003840 Q-loop/lid; other site 869215003841 ABC transporter signature motif; other site 869215003842 Walker B; other site 869215003843 D-loop; other site 869215003844 H-loop/switch region; other site 869215003845 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 869215003846 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869215003847 Walker A/P-loop; other site 869215003848 ATP binding site [chemical binding]; other site 869215003849 Q-loop/lid; other site 869215003850 ABC transporter signature motif; other site 869215003851 Walker B; other site 869215003852 D-loop; other site 869215003853 H-loop/switch region; other site 869215003854 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 869215003855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215003856 dimer interface [polypeptide binding]; other site 869215003857 conserved gate region; other site 869215003858 putative PBP binding loops; other site 869215003859 ABC-ATPase subunit interface; other site 869215003860 sulfate transport protein; Provisional; Region: cysT; CHL00187 869215003861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215003862 dimer interface [polypeptide binding]; other site 869215003863 conserved gate region; other site 869215003864 putative PBP binding loops; other site 869215003865 ABC-ATPase subunit interface; other site 869215003866 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 869215003867 phosphate binding protein; Region: ptsS_2; TIGR02136 869215003868 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 869215003869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215003870 S-adenosylmethionine binding site [chemical binding]; other site 869215003871 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 869215003872 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 869215003873 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 869215003874 active site 869215003875 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 869215003876 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 869215003877 ArsC family; Region: ArsC; pfam03960 869215003878 putative catalytic residues [active] 869215003879 thiol/disulfide switch; other site 869215003880 Predicted membrane protein [Function unknown]; Region: COG4478 869215003881 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 869215003882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215003883 active site 869215003884 motif I; other site 869215003885 motif II; other site 869215003886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215003887 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 869215003888 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869215003889 active site 869215003890 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869215003891 active site 869215003892 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 869215003893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869215003894 FeS/SAM binding site; other site 869215003895 HemN C-terminal domain; Region: HemN_C; pfam06969 869215003896 YtxH-like protein; Region: YtxH; pfam12732 869215003897 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 869215003898 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 869215003899 HPr kinase/phosphorylase; Provisional; Region: PRK05428 869215003900 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 869215003901 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 869215003902 Hpr binding site; other site 869215003903 active site 869215003904 homohexamer subunit interaction site [polypeptide binding]; other site 869215003905 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 869215003906 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 869215003907 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 869215003908 active site 869215003909 trimer interface [polypeptide binding]; other site 869215003910 allosteric site; other site 869215003911 active site lid [active] 869215003912 hexamer (dimer of trimers) interface [polypeptide binding]; other site 869215003913 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 869215003914 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 869215003915 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869215003916 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 869215003917 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869215003918 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869215003919 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869215003920 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 869215003921 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 869215003922 homodimer interface [polypeptide binding]; other site 869215003923 NAD binding pocket [chemical binding]; other site 869215003924 ATP binding pocket [chemical binding]; other site 869215003925 Mg binding site [ion binding]; other site 869215003926 active-site loop [active] 869215003927 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 869215003928 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 869215003929 active site 869215003930 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215003931 non-specific DNA binding site [nucleotide binding]; other site 869215003932 salt bridge; other site 869215003933 sequence-specific DNA binding site [nucleotide binding]; other site 869215003936 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869215003937 Peptidase family U32; Region: Peptidase_U32; pfam01136 869215003939 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 869215003940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215003941 S-adenosylmethionine binding site [chemical binding]; other site 869215003942 Helix-turn-helix domain; Region: HTH_18; pfam12833 869215003943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869215003944 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869215003945 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869215003946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215003947 Walker A/P-loop; other site 869215003948 ATP binding site [chemical binding]; other site 869215003949 Q-loop/lid; other site 869215003950 ABC transporter signature motif; other site 869215003951 Walker B; other site 869215003952 D-loop; other site 869215003953 H-loop/switch region; other site 869215003954 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869215003955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215003956 Walker A/P-loop; other site 869215003957 ATP binding site [chemical binding]; other site 869215003958 Q-loop/lid; other site 869215003959 ABC transporter signature motif; other site 869215003960 Walker B; other site 869215003961 D-loop; other site 869215003962 H-loop/switch region; other site 869215003963 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 869215003964 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869215003965 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869215003966 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869215003967 Walker A/P-loop; other site 869215003968 ATP binding site [chemical binding]; other site 869215003969 Q-loop/lid; other site 869215003970 ABC transporter signature motif; other site 869215003971 Walker B; other site 869215003972 D-loop; other site 869215003973 H-loop/switch region; other site 869215003974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215003975 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 869215003976 Walker A/P-loop; other site 869215003977 ATP binding site [chemical binding]; other site 869215003978 Q-loop/lid; other site 869215003979 ABC transporter signature motif; other site 869215003980 Walker B; other site 869215003981 D-loop; other site 869215003982 H-loop/switch region; other site 869215003985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 869215003986 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 869215003987 GMP synthase; Reviewed; Region: guaA; PRK00074 869215003988 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 869215003989 AMP/PPi binding site [chemical binding]; other site 869215003990 candidate oxyanion hole; other site 869215003991 catalytic triad [active] 869215003992 potential glutamine specificity residues [chemical binding]; other site 869215003993 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 869215003994 ATP Binding subdomain [chemical binding]; other site 869215003995 Dimerization subdomain; other site 869215003996 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869215003997 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869215003998 DNA-binding site [nucleotide binding]; DNA binding site 869215003999 UTRA domain; Region: UTRA; pfam07702 869215004000 EamA-like transporter family; Region: EamA; pfam00892 869215004001 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 869215004002 Beta-lactamase; Region: Beta-lactamase; pfam00144 869215004003 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 869215004004 active site 869215004005 catalytic triad [active] 869215004006 oxyanion hole [active] 869215004007 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869215004008 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215004009 active site 869215004010 motif I; other site 869215004011 motif II; other site 869215004012 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215004014 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 869215004015 active site 869215004016 catalytic residues [active] 869215004017 metal binding site [ion binding]; metal-binding site 869215004018 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 869215004019 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 869215004020 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869215004021 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 869215004022 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869215004023 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869215004024 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 869215004025 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869215004026 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869215004027 Walker A/P-loop; other site 869215004028 ATP binding site [chemical binding]; other site 869215004029 Q-loop/lid; other site 869215004030 ABC transporter signature motif; other site 869215004031 Walker B; other site 869215004032 D-loop; other site 869215004033 H-loop/switch region; other site 869215004034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869215004035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215004036 ABC-ATPase subunit interface; other site 869215004037 putative PBP binding loops; other site 869215004038 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 869215004039 putative ArsC-like catalytic residues; other site 869215004040 putative TRX-like catalytic residues [active] 869215004041 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 869215004042 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 869215004043 DNA binding site [nucleotide binding] 869215004044 active site 869215004045 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869215004046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 869215004047 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 869215004048 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 869215004049 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 869215004050 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 869215004051 predicted active site [active] 869215004052 catalytic triad [active] 869215004053 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 869215004054 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 869215004055 active site 869215004056 multimer interface [polypeptide binding]; other site 869215004057 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 869215004058 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869215004059 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869215004060 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 869215004061 ApbE family; Region: ApbE; pfam02424 869215004062 Predicted flavoprotein [General function prediction only]; Region: COG0431 869215004063 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869215004064 Predicted flavoprotein [General function prediction only]; Region: COG0431 869215004065 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869215004066 PAS domain; Region: PAS_10; pfam13596 869215004067 hypothetical protein; Provisional; Region: PRK02539 869215004068 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 869215004069 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 869215004070 DALR anticodon binding domain; Region: DALR_1; pfam05746 869215004071 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 869215004072 dimer interface [polypeptide binding]; other site 869215004073 motif 1; other site 869215004074 active site 869215004075 motif 2; other site 869215004076 motif 3; other site 869215004077 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 869215004078 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869215004079 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869215004080 active site 869215004081 catalytic tetrad [active] 869215004082 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 869215004083 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 869215004084 NodB motif; other site 869215004085 active site 869215004086 catalytic site [active] 869215004087 Zn binding site [ion binding]; other site 869215004088 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 869215004089 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869215004090 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869215004091 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 869215004092 DEAD-like helicases superfamily; Region: DEXDc; smart00487 869215004093 ATP binding site [chemical binding]; other site 869215004094 putative Mg++ binding site [ion binding]; other site 869215004095 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869215004096 nucleotide binding region [chemical binding]; other site 869215004097 ATP-binding site [chemical binding]; other site 869215004099 elongation factor Tu; Reviewed; Region: PRK00049 869215004100 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 869215004101 G1 box; other site 869215004102 GEF interaction site [polypeptide binding]; other site 869215004103 GTP/Mg2+ binding site [chemical binding]; other site 869215004104 Switch I region; other site 869215004105 G2 box; other site 869215004106 G3 box; other site 869215004107 Switch II region; other site 869215004108 G4 box; other site 869215004109 G5 box; other site 869215004110 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 869215004111 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 869215004112 Antibiotic Binding Site [chemical binding]; other site 869215004113 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 869215004114 amphipathic channel; other site 869215004115 Asn-Pro-Ala signature motifs; other site 869215004118 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 869215004119 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 869215004120 active site 869215004121 substrate binding site [chemical binding]; other site 869215004122 metal binding site [ion binding]; metal-binding site 869215004123 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869215004124 catalytic residues [active] 869215004125 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869215004126 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869215004127 substrate binding pocket [chemical binding]; other site 869215004128 membrane-bound complex binding site; other site 869215004129 hinge residues; other site 869215004130 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869215004131 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215004132 Walker A/P-loop; other site 869215004133 ATP binding site [chemical binding]; other site 869215004134 Q-loop/lid; other site 869215004135 ABC transporter signature motif; other site 869215004136 Walker B; other site 869215004137 D-loop; other site 869215004138 H-loop/switch region; other site 869215004139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215004140 dimer interface [polypeptide binding]; other site 869215004141 conserved gate region; other site 869215004142 putative PBP binding loops; other site 869215004143 ABC-ATPase subunit interface; other site 869215004144 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 869215004145 TPR motif; other site 869215004146 binding surface 869215004147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869215004148 binding surface 869215004149 TPR motif; other site 869215004150 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 869215004151 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869215004152 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 869215004153 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 869215004154 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 869215004155 gamma subunit interface [polypeptide binding]; other site 869215004156 epsilon subunit interface [polypeptide binding]; other site 869215004157 LBP interface [polypeptide binding]; other site 869215004158 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 869215004159 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869215004160 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 869215004161 alpha subunit interaction interface [polypeptide binding]; other site 869215004162 Walker A motif; other site 869215004163 ATP binding site [chemical binding]; other site 869215004164 Walker B motif; other site 869215004165 inhibitor binding site; inhibition site 869215004166 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869215004167 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 869215004168 core domain interface [polypeptide binding]; other site 869215004169 delta subunit interface [polypeptide binding]; other site 869215004170 epsilon subunit interface [polypeptide binding]; other site 869215004171 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 869215004172 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869215004173 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 869215004174 beta subunit interaction interface [polypeptide binding]; other site 869215004175 Walker A motif; other site 869215004176 ATP binding site [chemical binding]; other site 869215004177 Walker B motif; other site 869215004178 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869215004179 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 869215004180 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 869215004181 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 869215004182 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 869215004183 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 869215004184 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 869215004185 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 869215004187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869215004188 Coenzyme A binding pocket [chemical binding]; other site 869215004189 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 869215004190 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 869215004191 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 869215004192 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 869215004193 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 869215004194 dimerization interface [polypeptide binding]; other site 869215004195 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 869215004196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869215004197 Coenzyme A binding pocket [chemical binding]; other site 869215004198 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869215004199 Coenzyme A binding pocket [chemical binding]; other site 869215004200 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 869215004201 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869215004202 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869215004203 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869215004204 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 869215004205 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 869215004206 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869215004207 ATP binding site [chemical binding]; other site 869215004208 putative Mg++ binding site [ion binding]; other site 869215004209 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869215004210 nucleotide binding region [chemical binding]; other site 869215004211 ATP-binding site [chemical binding]; other site 869215004212 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 869215004213 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869215004214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215004215 homodimer interface [polypeptide binding]; other site 869215004216 catalytic residue [active] 869215004217 cystathionine gamma-synthase; Reviewed; Region: PRK07269 869215004218 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 869215004219 homodimer interface [polypeptide binding]; other site 869215004220 substrate-cofactor binding pocket; other site 869215004221 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215004222 catalytic residue [active] 869215004224 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869215004225 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869215004226 peptide binding site [polypeptide binding]; other site 869215004227 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869215004228 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 869215004229 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 869215004230 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869215004231 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869215004232 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869215004233 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 869215004234 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 869215004235 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 869215004236 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 869215004237 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 869215004238 DHH family; Region: DHH; pfam01368 869215004239 DHHA2 domain; Region: DHHA2; pfam02833 869215004240 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 869215004241 GIY-YIG motif/motif A; other site 869215004242 putative active site [active] 869215004243 putative metal binding site [ion binding]; other site 869215004244 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 869215004245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215004246 S-adenosylmethionine binding site [chemical binding]; other site 869215004247 hypothetical protein; Provisional; Region: PRK07252 869215004248 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 869215004249 RNA binding site [nucleotide binding]; other site 869215004250 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215004251 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869215004252 active site 869215004253 motif I; other site 869215004254 motif II; other site 869215004255 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215004256 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 869215004257 active site 869215004258 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 869215004259 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869215004260 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869215004261 dimer interface [polypeptide binding]; other site 869215004262 ssDNA binding site [nucleotide binding]; other site 869215004263 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869215004264 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 869215004265 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 869215004266 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 869215004267 putative dimer interface [polypeptide binding]; other site 869215004268 putative anticodon binding site; other site 869215004269 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 869215004270 homodimer interface [polypeptide binding]; other site 869215004271 motif 1; other site 869215004272 motif 2; other site 869215004273 active site 869215004274 motif 3; other site 869215004275 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 869215004276 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869215004277 aspartate aminotransferase; Provisional; Region: PRK05764 869215004278 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869215004279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215004280 homodimer interface [polypeptide binding]; other site 869215004281 catalytic residue [active] 869215004282 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 869215004283 Predicted flavoprotein [General function prediction only]; Region: COG0431 869215004284 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869215004285 hypothetical protein; Validated; Region: PRK02101 869215004286 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 869215004287 active site 869215004288 catalytic residues [active] 869215004289 metal binding site [ion binding]; metal-binding site 869215004290 putative S-transferase; Provisional; Region: PRK11752 869215004291 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 869215004292 C-terminal domain interface [polypeptide binding]; other site 869215004293 GSH binding site (G-site) [chemical binding]; other site 869215004294 dimer interface [polypeptide binding]; other site 869215004295 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 869215004296 N-terminal domain interface [polypeptide binding]; other site 869215004297 dimer interface [polypeptide binding]; other site 869215004298 substrate binding pocket (H-site) [chemical binding]; other site 869215004299 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 869215004300 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 869215004301 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869215004302 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 869215004303 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 869215004304 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 869215004305 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 869215004306 Cation efflux family; Region: Cation_efflux; pfam01545 869215004307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 869215004308 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869215004309 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215004310 Walker A/P-loop; other site 869215004311 ATP binding site [chemical binding]; other site 869215004312 Q-loop/lid; other site 869215004313 ABC transporter signature motif; other site 869215004314 Walker B; other site 869215004315 D-loop; other site 869215004316 H-loop/switch region; other site 869215004317 ABC transporter; Region: ABC_tran_2; pfam12848 869215004318 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869215004319 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 869215004320 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 869215004321 active site 869215004322 NTP binding site [chemical binding]; other site 869215004323 metal binding triad [ion binding]; metal-binding site 869215004324 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 869215004325 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 869215004326 dihydrodipicolinate reductase; Provisional; Region: PRK00048 869215004327 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 869215004328 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 869215004329 EDD domain protein, DegV family; Region: DegV; TIGR00762 869215004330 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 869215004331 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 869215004332 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 869215004333 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 869215004334 active site 869215004335 substrate binding site [chemical binding]; other site 869215004336 metal binding site [ion binding]; metal-binding site 869215004337 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 869215004338 YbbR-like protein; Region: YbbR; pfam07949 869215004339 Uncharacterized conserved protein [Function unknown]; Region: COG1624 869215004340 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 869215004341 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 869215004342 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869215004343 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869215004344 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 869215004345 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 869215004346 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 869215004347 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 869215004348 dimer interface [polypeptide binding]; other site 869215004349 phosphate binding site [ion binding]; other site 869215004350 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 869215004351 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 869215004352 homotrimer interaction site [polypeptide binding]; other site 869215004353 putative active site [active] 869215004354 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 869215004355 G1 box; other site 869215004356 GTP/Mg2+ binding site [chemical binding]; other site 869215004357 Switch I region; other site 869215004358 G2 box; other site 869215004359 G3 box; other site 869215004360 Switch II region; other site 869215004361 G4 box; other site 869215004362 G5 box; other site 869215004363 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 869215004364 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 869215004365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215004366 Walker A motif; other site 869215004367 ATP binding site [chemical binding]; other site 869215004368 Walker B motif; other site 869215004369 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869215004370 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 869215004371 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 869215004372 folate binding site [chemical binding]; other site 869215004373 NADP+ binding site [chemical binding]; other site 869215004374 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 869215004375 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 869215004376 dimerization interface [polypeptide binding]; other site 869215004377 DPS ferroxidase diiron center [ion binding]; other site 869215004378 ion pore; other site 869215004380 triosephosphate isomerase; Provisional; Region: PRK14567 869215004381 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 869215004382 substrate binding site [chemical binding]; other site 869215004383 dimer interface [polypeptide binding]; other site 869215004384 catalytic triad [active] 869215004385 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 869215004386 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 869215004387 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 869215004388 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 869215004389 proposed active site lysine [active] 869215004390 conserved cys residue [active] 869215004391 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869215004392 active site 869215004393 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869215004394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215004395 S-adenosylmethionine binding site [chemical binding]; other site 869215004396 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 869215004397 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 869215004398 Walker A/P-loop; other site 869215004399 ATP binding site [chemical binding]; other site 869215004400 Q-loop/lid; other site 869215004401 ABC transporter signature motif; other site 869215004402 Walker B; other site 869215004403 D-loop; other site 869215004404 H-loop/switch region; other site 869215004405 TOBE domain; Region: TOBE_2; pfam08402 869215004406 Isochorismatase family; Region: Isochorismatase; pfam00857 869215004407 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 869215004408 catalytic triad [active] 869215004409 conserved cis-peptide bond; other site 869215004410 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 869215004411 CodY GAF-like domain; Region: CodY; pfam06018 869215004412 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869215004413 putative DNA binding site [nucleotide binding]; other site 869215004414 putative Zn2+ binding site [ion binding]; other site 869215004415 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 869215004416 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 869215004417 ATP binding site [chemical binding]; other site 869215004418 Mg++ binding site [ion binding]; other site 869215004419 motif III; other site 869215004420 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869215004421 nucleotide binding region [chemical binding]; other site 869215004422 ATP-binding site [chemical binding]; other site 869215004423 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 869215004424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869215004425 putative substrate translocation pore; other site 869215004426 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 869215004427 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 869215004428 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869215004429 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869215004430 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 869215004431 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869215004432 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 869215004433 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 869215004434 catalytic triad [active] 869215004435 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 869215004436 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 869215004437 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 869215004438 active site 869215004439 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869215004440 putative transposase OrfB; Reviewed; Region: PHA02517 869215004441 HTH-like domain; Region: HTH_21; pfam13276 869215004442 Integrase core domain; Region: rve; pfam00665 869215004443 Integrase core domain; Region: rve_2; pfam13333 869215004445 Predicted membrane protein [Function unknown]; Region: COG4720 869215004446 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 869215004447 dimer interface [polypeptide binding]; other site 869215004448 substrate binding site [chemical binding]; other site 869215004449 ATP binding site [chemical binding]; other site 869215004450 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 869215004451 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 869215004452 dimerization interface 3.5A [polypeptide binding]; other site 869215004453 active site 869215004454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869215004455 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 869215004456 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 869215004457 PhnA protein; Region: PhnA; pfam03831 869215004458 cytidylate kinase; Provisional; Region: cmk; PRK00023 869215004459 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 869215004460 CMP-binding site; other site 869215004461 The sites determining sugar specificity; other site 869215004462 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 869215004463 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 869215004464 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 869215004465 Ligand binding site; other site 869215004466 Putative Catalytic site; other site 869215004467 DXD motif; other site 869215004468 UDP-glucose 4-epimerase; Region: PLN02240 869215004469 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 869215004470 NAD binding site [chemical binding]; other site 869215004471 homodimer interface [polypeptide binding]; other site 869215004472 active site 869215004473 substrate binding site [chemical binding]; other site 869215004474 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 869215004475 Uncharacterized conserved protein [Function unknown]; Region: COG0327 869215004476 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 869215004477 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 869215004478 Family of unknown function (DUF633); Region: DUF633; pfam04816 869215004479 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 869215004480 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 869215004481 putative transposase OrfB; Reviewed; Region: PHA02517 869215004482 HTH-like domain; Region: HTH_21; pfam13276 869215004483 Integrase core domain; Region: rve; pfam00665 869215004484 Integrase core domain; Region: rve_2; pfam13333 869215004486 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 869215004487 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869215004488 TPP-binding site [chemical binding]; other site 869215004489 dimer interface [polypeptide binding]; other site 869215004490 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869215004491 PYR/PP interface [polypeptide binding]; other site 869215004492 dimer interface [polypeptide binding]; other site 869215004493 TPP binding site [chemical binding]; other site 869215004494 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869215004495 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 869215004496 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 869215004497 substrate binding site [chemical binding]; other site 869215004498 hexamer interface [polypeptide binding]; other site 869215004499 metal binding site [ion binding]; metal-binding site 869215004500 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 869215004501 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 869215004502 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 869215004503 active site 869215004504 P-loop; other site 869215004505 phosphorylation site [posttranslational modification] 869215004506 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869215004507 active site 869215004508 phosphorylation site [posttranslational modification] 869215004509 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869215004510 active site 869215004511 phosphorylation site [posttranslational modification] 869215004512 HTH domain; Region: HTH_11; pfam08279 869215004513 Mga helix-turn-helix domain; Region: Mga; pfam05043 869215004514 PRD domain; Region: PRD; pfam00874 869215004515 PRD domain; Region: PRD; pfam00874 869215004516 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869215004517 active site 869215004518 P-loop; other site 869215004519 phosphorylation site [posttranslational modification] 869215004520 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 869215004521 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869215004522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215004523 motif II; other site 869215004524 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 869215004525 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 869215004526 putative acyl-acceptor binding pocket; other site 869215004527 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 869215004528 Cadmium resistance transporter; Region: Cad; pfam03596 869215004529 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 869215004530 16S/18S rRNA binding site [nucleotide binding]; other site 869215004531 S13e-L30e interaction site [polypeptide binding]; other site 869215004532 25S rRNA binding site [nucleotide binding]; other site 869215004533 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 869215004534 NADH(P)-binding; Region: NAD_binding_10; pfam13460 869215004535 NAD binding site [chemical binding]; other site 869215004536 substrate binding site [chemical binding]; other site 869215004537 putative active site [active] 869215004538 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 869215004539 metal binding site [ion binding]; metal-binding site 869215004540 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 869215004541 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 869215004542 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 869215004543 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 869215004544 active site 869215004545 dimer interface [polypeptide binding]; other site 869215004546 motif 1; other site 869215004547 motif 2; other site 869215004548 motif 3; other site 869215004549 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 869215004550 anticodon binding site; other site 869215004551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869215004552 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215004553 ATP binding site [chemical binding]; other site 869215004554 Mg2+ binding site [ion binding]; other site 869215004555 G-X-G motif; other site 869215004556 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869215004557 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869215004558 active site 869215004559 phosphorylation site [posttranslational modification] 869215004560 intermolecular recognition site; other site 869215004561 dimerization interface [polypeptide binding]; other site 869215004562 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869215004563 DNA binding site [nucleotide binding] 869215004564 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 869215004565 nucleophilic elbow; other site 869215004566 catalytic triad; other site 869215004567 Predicted transcriptional regulator [Transcription]; Region: COG1959 869215004568 Transcriptional regulator; Region: Rrf2; pfam02082 869215004570 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 869215004571 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 869215004572 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 869215004573 FeoA domain; Region: FeoA; pfam04023 869215004575 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 869215004576 putative active site [active] 869215004577 dimerization interface [polypeptide binding]; other site 869215004578 putative tRNAtyr binding site [nucleotide binding]; other site 869215004579 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 869215004580 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869215004581 Zn2+ binding site [ion binding]; other site 869215004582 Mg2+ binding site [ion binding]; other site 869215004583 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869215004584 synthetase active site [active] 869215004585 NTP binding site [chemical binding]; other site 869215004586 metal binding site [ion binding]; metal-binding site 869215004587 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 869215004588 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 869215004589 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 869215004590 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 869215004591 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 869215004592 active site 869215004593 Zn binding site [ion binding]; other site 869215004594 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 869215004595 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 869215004596 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 869215004597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869215004598 ABC-ATPase subunit interface; other site 869215004599 dimer interface [polypeptide binding]; other site 869215004600 putative PBP binding regions; other site 869215004601 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869215004602 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 869215004603 metal binding site [ion binding]; metal-binding site 869215004604 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 869215004605 dimer interface [polypeptide binding]; other site 869215004606 catalytic triad [active] 869215004607 peroxidatic and resolving cysteines [active] 869215004609 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869215004610 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869215004611 Walker A/P-loop; other site 869215004612 ATP binding site [chemical binding]; other site 869215004613 Q-loop/lid; other site 869215004614 ABC transporter signature motif; other site 869215004615 Walker B; other site 869215004616 D-loop; other site 869215004617 H-loop/switch region; other site 869215004619 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869215004620 catalytic core [active] 869215004621 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869215004622 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 869215004623 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869215004624 active site 869215004625 HIGH motif; other site 869215004626 nucleotide binding site [chemical binding]; other site 869215004627 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 869215004628 active site 869215004629 KMSKS motif; other site 869215004630 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 869215004631 tRNA binding surface [nucleotide binding]; other site 869215004632 anticodon binding site; other site 869215004633 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 869215004635 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 869215004636 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869215004637 RNA binding surface [nucleotide binding]; other site 869215004638 YGGT family; Region: YGGT; pfam02325 869215004639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 869215004640 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 869215004641 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869215004642 catalytic residue [active] 869215004643 cell division protein FtsZ; Validated; Region: PRK09330 869215004644 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 869215004645 nucleotide binding site [chemical binding]; other site 869215004646 SulA interaction site; other site 869215004647 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 869215004648 Cell division protein FtsA; Region: FtsA; smart00842 869215004649 Cell division protein FtsA; Region: FtsA; pfam14450 869215004650 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 869215004651 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 869215004652 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 869215004653 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 869215004654 nudix motif; other site 869215004655 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 869215004656 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869215004657 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869215004658 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869215004659 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 869215004660 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 869215004661 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 869215004662 recombination protein RecR; Reviewed; Region: recR; PRK00076 869215004663 RecR protein; Region: RecR; pfam02132 869215004664 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 869215004665 putative active site [active] 869215004666 putative metal-binding site [ion binding]; other site 869215004667 tetramer interface [polypeptide binding]; other site 869215004668 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 869215004669 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869215004670 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869215004671 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 869215004672 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 869215004673 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 869215004674 putative active site [active] 869215004675 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869215004676 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869215004677 nucleotide binding site [chemical binding]; other site 869215004678 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 869215004679 Class I aldolases; Region: Aldolase_Class_I; cl17187 869215004680 catalytic residue [active] 869215004681 Protein of unknown function, DUF624; Region: DUF624; pfam04854 869215004682 Domain of unknown function (DUF386); Region: DUF386; pfam04074 869215004683 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869215004684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215004685 dimer interface [polypeptide binding]; other site 869215004686 conserved gate region; other site 869215004687 putative PBP binding loops; other site 869215004688 ABC-ATPase subunit interface; other site 869215004689 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869215004690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869215004691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215004692 putative PBP binding loops; other site 869215004693 dimer interface [polypeptide binding]; other site 869215004694 ABC-ATPase subunit interface; other site 869215004695 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869215004696 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869215004697 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 869215004698 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869215004699 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869215004700 active site turn [active] 869215004701 phosphorylation site [posttranslational modification] 869215004702 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 869215004703 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 869215004704 putative active site cavity [active] 869215004705 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869215004706 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869215004707 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869215004708 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 869215004709 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 869215004710 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869215004711 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869215004712 Asp-box motif; other site 869215004713 catalytic site [active] 869215004714 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869215004715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215004716 dimer interface [polypeptide binding]; other site 869215004717 conserved gate region; other site 869215004718 putative PBP binding loops; other site 869215004719 ABC-ATPase subunit interface; other site 869215004720 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869215004721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215004722 dimer interface [polypeptide binding]; other site 869215004723 conserved gate region; other site 869215004724 putative PBP binding loops; other site 869215004725 ABC-ATPase subunit interface; other site 869215004726 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869215004727 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869215004728 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 869215004729 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869215004730 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 869215004731 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869215004732 Asp-box motif; other site 869215004733 catalytic site [active] 869215004734 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 869215004735 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 869215004736 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 869215004737 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 869215004738 ssDNA binding site; other site 869215004739 generic binding surface II; other site 869215004740 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869215004741 ATP binding site [chemical binding]; other site 869215004742 putative Mg++ binding site [ion binding]; other site 869215004743 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869215004744 nucleotide binding region [chemical binding]; other site 869215004745 ATP-binding site [chemical binding]; other site 869215004746 alanine racemase; Reviewed; Region: alr; PRK00053 869215004747 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 869215004748 active site 869215004749 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869215004750 dimer interface [polypeptide binding]; other site 869215004751 substrate binding site [chemical binding]; other site 869215004752 catalytic residues [active] 869215004753 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 869215004754 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 869215004755 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 869215004756 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 869215004757 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 869215004758 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 869215004759 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 869215004760 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869215004761 nucleotide binding region [chemical binding]; other site 869215004762 ATP-binding site [chemical binding]; other site 869215004763 SEC-C motif; Region: SEC-C; pfam02810 869215004764 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 869215004765 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869215004766 Walker A/P-loop; other site 869215004767 ATP binding site [chemical binding]; other site 869215004768 Q-loop/lid; other site 869215004769 ABC transporter signature motif; other site 869215004770 Walker B; other site 869215004771 D-loop; other site 869215004772 H-loop/switch region; other site 869215004773 GTP-binding protein Der; Reviewed; Region: PRK00093 869215004774 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 869215004775 G1 box; other site 869215004776 GTP/Mg2+ binding site [chemical binding]; other site 869215004777 Switch I region; other site 869215004778 G2 box; other site 869215004779 Switch II region; other site 869215004780 G3 box; other site 869215004781 G4 box; other site 869215004782 G5 box; other site 869215004783 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 869215004784 G1 box; other site 869215004785 GTP/Mg2+ binding site [chemical binding]; other site 869215004786 Switch I region; other site 869215004787 G2 box; other site 869215004788 G3 box; other site 869215004789 Switch II region; other site 869215004790 G4 box; other site 869215004791 G5 box; other site 869215004792 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 869215004793 dimer interface [polypeptide binding]; other site 869215004794 FMN binding site [chemical binding]; other site 869215004795 NADPH bind site [chemical binding]; other site 869215004796 primosomal protein DnaI; Reviewed; Region: PRK08939 869215004797 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 869215004798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215004799 Walker A motif; other site 869215004800 ATP binding site [chemical binding]; other site 869215004801 Walker B motif; other site 869215004802 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 869215004803 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 869215004804 ATP cone domain; Region: ATP-cone; pfam03477 869215004805 Predicted transcriptional regulators [Transcription]; Region: COG1725 869215004806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869215004807 DNA-binding site [nucleotide binding]; DNA binding site 869215004808 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 869215004809 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869215004810 Walker A/P-loop; other site 869215004811 ATP binding site [chemical binding]; other site 869215004812 Q-loop/lid; other site 869215004813 ABC transporter signature motif; other site 869215004814 Walker B; other site 869215004815 D-loop; other site 869215004816 H-loop/switch region; other site 869215004817 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 869215004818 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 869215004819 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215004820 Walker A/P-loop; other site 869215004821 ATP binding site [chemical binding]; other site 869215004822 Q-loop/lid; other site 869215004823 ABC transporter signature motif; other site 869215004824 Walker B; other site 869215004825 D-loop; other site 869215004826 H-loop/switch region; other site 869215004827 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 869215004828 Uncharacterized conserved protein [Function unknown]; Region: COG0398 869215004829 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 869215004830 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869215004831 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869215004832 nucleotide binding site [chemical binding]; other site 869215004833 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 869215004834 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869215004835 active site turn [active] 869215004836 phosphorylation site [posttranslational modification] 869215004837 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869215004838 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 869215004839 HPr interaction site; other site 869215004840 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869215004841 active site 869215004842 phosphorylation site [posttranslational modification] 869215004843 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 869215004844 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 869215004845 substrate binding [chemical binding]; other site 869215004846 active site 869215004847 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 869215004848 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869215004849 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869215004850 DNA binding site [nucleotide binding] 869215004851 domain linker motif; other site 869215004852 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 869215004853 dimerization interface [polypeptide binding]; other site 869215004854 ligand binding site [chemical binding]; other site 869215004855 sodium binding site [ion binding]; other site 869215004856 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 869215004857 homodimer interface [polypeptide binding]; other site 869215004858 catalytic residues [active] 869215004859 NAD binding site [chemical binding]; other site 869215004860 substrate binding pocket [chemical binding]; other site 869215004861 flexible flap; other site 869215004862 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 869215004863 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 869215004864 dimer interface [polypeptide binding]; other site 869215004865 active site 869215004866 IS1381 orfs A and B appear to have fused into the same reading frame due to a small deletion 869215004867 Uncharacterized conserved protein [Function unknown]; Region: COG3610 869215004868 Uncharacterized conserved protein [Function unknown]; Region: COG2966 869215004869 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 869215004870 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 869215004871 Catalytic domain of Protein Kinases; Region: PKc; cd00180 869215004872 active site 869215004873 ATP binding site [chemical binding]; other site 869215004874 substrate binding site [chemical binding]; other site 869215004875 activation loop (A-loop); other site 869215004876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 869215004877 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 869215004878 PASTA domain; Region: PASTA; smart00740 869215004879 PASTA domain; Region: PASTA; smart00740 869215004880 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 869215004881 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 869215004882 active site 869215004883 16S rRNA methyltransferase B; Provisional; Region: PRK14902 869215004884 NusB family; Region: NusB; pfam01029 869215004885 putative RNA binding site [nucleotide binding]; other site 869215004886 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215004887 S-adenosylmethionine binding site [chemical binding]; other site 869215004888 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 869215004889 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 869215004890 putative active site [active] 869215004891 substrate binding site [chemical binding]; other site 869215004892 putative cosubstrate binding site; other site 869215004893 catalytic site [active] 869215004894 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 869215004895 substrate binding site [chemical binding]; other site 869215004896 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 869215004897 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869215004898 ATP binding site [chemical binding]; other site 869215004899 putative Mg++ binding site [ion binding]; other site 869215004900 helicase superfamily c-terminal domain; Region: HELICc; smart00490 869215004901 ATP-binding site [chemical binding]; other site 869215004902 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 869215004903 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 869215004904 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 869215004905 catalytic site [active] 869215004906 G-X2-G-X-G-K; other site 869215004907 hypothetical protein; Provisional; Region: PRK00106 869215004908 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869215004909 Zn2+ binding site [ion binding]; other site 869215004910 Mg2+ binding site [ion binding]; other site 869215004911 hypothetical protein; Provisional; Region: PRK13670 869215004912 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 869215004913 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 869215004914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215004915 S-adenosylmethionine binding site [chemical binding]; other site 869215004916 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 869215004917 Isochorismatase family; Region: Isochorismatase; pfam00857 869215004918 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 869215004919 catalytic triad [active] 869215004920 conserved cis-peptide bond; other site 869215004921 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869215004922 Zn2+ binding site [ion binding]; other site 869215004923 Mg2+ binding site [ion binding]; other site 869215004924 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 869215004925 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 869215004926 active site 869215004927 (T/H)XGH motif; other site 869215004928 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 869215004929 GTPase YqeH; Provisional; Region: PRK13796 869215004930 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 869215004931 GTP/Mg2+ binding site [chemical binding]; other site 869215004932 G4 box; other site 869215004933 G5 box; other site 869215004934 G1 box; other site 869215004935 Switch I region; other site 869215004936 G2 box; other site 869215004937 G3 box; other site 869215004938 Switch II region; other site 869215004939 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 869215004940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215004941 active site 869215004942 motif I; other site 869215004943 motif II; other site 869215004944 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 869215004945 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 869215004946 Cl binding site [ion binding]; other site 869215004947 oligomer interface [polypeptide binding]; other site 869215004948 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 869215004949 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869215004950 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 869215004951 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 869215004952 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 869215004953 Predicted membrane protein [Function unknown]; Region: COG4129 869215004954 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 869215004955 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 869215004956 MarR family; Region: MarR; pfam01047 869215004957 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869215004958 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869215004959 catalytic residues [active] 869215004960 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 869215004961 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 869215004962 amphipathic channel; other site 869215004963 Asn-Pro-Ala signature motifs; other site 869215004964 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 869215004965 oligoendopeptidase F; Region: pepF; TIGR00181 869215004966 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 869215004967 Zn binding site [ion binding]; other site 869215004968 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 869215004969 RNA methyltransferase, RsmE family; Region: TIGR00046 869215004970 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 869215004971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215004972 S-adenosylmethionine binding site [chemical binding]; other site 869215004973 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 869215004974 nudix motif; other site 869215004975 Peptidase family M50; Region: Peptidase_M50; pfam02163 869215004976 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 869215004977 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 869215004978 recombination factor protein RarA; Reviewed; Region: PRK13342 869215004979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215004980 Walker A motif; other site 869215004981 ATP binding site [chemical binding]; other site 869215004982 Walker B motif; other site 869215004983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 869215004984 arginine finger; other site 869215004985 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 869215004986 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 869215004987 Int/Topo IB signature motif; other site 869215004988 Replication initiation factor; Region: Rep_trans; pfam02486 869215004989 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869215004990 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 869215004991 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 869215004992 substrate binding [chemical binding]; other site 869215004993 active site 869215004994 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 869215004995 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869215004996 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869215004997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215004998 dimer interface [polypeptide binding]; other site 869215004999 conserved gate region; other site 869215005000 ABC-ATPase subunit interface; other site 869215005001 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869215005002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215005003 dimer interface [polypeptide binding]; other site 869215005004 conserved gate region; other site 869215005005 ABC-ATPase subunit interface; other site 869215005006 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869215005007 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869215005008 DNA binding site [nucleotide binding] 869215005009 domain linker motif; other site 869215005010 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 869215005011 dimerization interface [polypeptide binding]; other site 869215005012 ligand binding site [chemical binding]; other site 869215005013 sodium binding site [ion binding]; other site 869215005014 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 869215005015 Mga helix-turn-helix domain; Region: Mga; pfam05043 869215005016 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 869215005017 Predicted membrane protein [Function unknown]; Region: COG2261 869215005018 Small integral membrane protein [Function unknown]; Region: COG5547 869215005019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 869215005021 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 869215005022 Uncharacterized conserved protein [Function unknown]; Region: COG1262 869215005023 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 869215005024 arylsulfatase; Provisional; Region: PRK13759 869215005025 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 869215005026 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869215005027 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 869215005028 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869215005029 active site 869215005030 methionine cluster; other site 869215005031 phosphorylation site [posttranslational modification] 869215005032 metal binding site [ion binding]; metal-binding site 869215005033 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 869215005034 active site 869215005035 P-loop; other site 869215005036 phosphorylation site [posttranslational modification] 869215005037 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 869215005038 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869215005039 MarR family; Region: MarR_2; pfam12802 869215005040 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869215005041 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869215005042 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869215005043 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869215005044 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869215005045 Coenzyme A binding pocket [chemical binding]; other site 869215005046 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 869215005047 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 869215005048 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 869215005049 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869215005050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215005051 non-specific DNA binding site [nucleotide binding]; other site 869215005052 salt bridge; other site 869215005053 sequence-specific DNA binding site [nucleotide binding]; other site 869215005054 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 869215005055 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 869215005056 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 869215005057 substrate binding site [chemical binding]; other site 869215005058 active site 869215005059 catalytic residues [active] 869215005060 heterodimer interface [polypeptide binding]; other site 869215005061 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 869215005062 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 869215005063 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215005064 catalytic residue [active] 869215005065 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 869215005066 active site 869215005067 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 869215005068 active site 869215005069 ribulose/triose binding site [chemical binding]; other site 869215005070 phosphate binding site [ion binding]; other site 869215005071 substrate (anthranilate) binding pocket [chemical binding]; other site 869215005072 product (indole) binding pocket [chemical binding]; other site 869215005073 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 869215005074 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869215005075 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869215005076 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 869215005077 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 869215005078 glutamine binding [chemical binding]; other site 869215005079 catalytic triad [active] 869215005080 anthranilate synthase component I; Provisional; Region: PRK13570 869215005081 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 869215005082 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 869215005083 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869215005084 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869215005085 DNA binding site [nucleotide binding] 869215005086 domain linker motif; other site 869215005087 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 869215005088 putative dimerization interface [polypeptide binding]; other site 869215005089 putative ligand binding site [chemical binding]; other site 869215005090 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 869215005091 MgtC family; Region: MgtC; pfam02308 869215005092 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 869215005093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215005094 dimer interface [polypeptide binding]; other site 869215005095 conserved gate region; other site 869215005096 putative PBP binding loops; other site 869215005097 ABC-ATPase subunit interface; other site 869215005098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215005099 putative PBP binding loops; other site 869215005100 dimer interface [polypeptide binding]; other site 869215005101 ABC-ATPase subunit interface; other site 869215005102 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869215005103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215005104 Walker A/P-loop; other site 869215005105 ATP binding site [chemical binding]; other site 869215005106 Q-loop/lid; other site 869215005107 ABC transporter signature motif; other site 869215005108 Walker B; other site 869215005109 D-loop; other site 869215005110 H-loop/switch region; other site 869215005111 TOBE domain; Region: TOBE; pfam03459 869215005112 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 869215005113 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869215005114 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 869215005115 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 869215005117 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869215005118 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 869215005119 Pectate lyase; Region: Pec_lyase_C; cl01593 869215005120 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 869215005121 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 869215005122 inhibitor-cofactor binding pocket; inhibition site 869215005123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215005124 catalytic residue [active] 869215005125 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 869215005126 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869215005127 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869215005128 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 869215005129 Walker A/P-loop; other site 869215005130 ATP binding site [chemical binding]; other site 869215005131 Q-loop/lid; other site 869215005132 ABC transporter signature motif; other site 869215005133 Walker B; other site 869215005134 D-loop; other site 869215005135 H-loop/switch region; other site 869215005136 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869215005137 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 869215005138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215005139 Walker A/P-loop; other site 869215005140 ATP binding site [chemical binding]; other site 869215005141 Q-loop/lid; other site 869215005142 ABC transporter signature motif; other site 869215005143 Walker B; other site 869215005144 D-loop; other site 869215005145 H-loop/switch region; other site 869215005147 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 869215005148 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 869215005149 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 869215005150 active site 869215005151 putative catalytic site [active] 869215005152 DNA binding site [nucleotide binding] 869215005153 putative phosphate binding site [ion binding]; other site 869215005154 metal binding site A [ion binding]; metal-binding site 869215005155 AP binding site [nucleotide binding]; other site 869215005156 metal binding site B [ion binding]; metal-binding site 869215005157 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869215005158 active site 869215005159 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869215005160 active site 869215005161 xanthine permease; Region: pbuX; TIGR03173 869215005162 Sulfate transporter family; Region: Sulfate_transp; pfam00916 869215005163 DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207 869215005164 Dam-replacing family; Region: DRP; pfam06044 869215005165 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 869215005166 CoenzymeA binding site [chemical binding]; other site 869215005167 subunit interaction site [polypeptide binding]; other site 869215005168 PHB binding site; other site 869215005169 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 869215005170 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 869215005171 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 869215005172 galactokinase; Provisional; Region: PRK05322 869215005173 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 869215005174 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869215005175 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869215005176 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 869215005177 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869215005178 DNA binding site [nucleotide binding] 869215005179 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 869215005180 putative dimerization interface [polypeptide binding]; other site 869215005181 putative ligand binding site [chemical binding]; other site 869215005182 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 869215005183 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869215005184 catalytic Zn binding site [ion binding]; other site 869215005185 NAD(P) binding site [chemical binding]; other site 869215005186 structural Zn binding site [ion binding]; other site 869215005187 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 869215005188 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 869215005189 DNA binding residues [nucleotide binding] 869215005190 putative dimer interface [polypeptide binding]; other site 869215005191 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 869215005192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869215005193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869215005194 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 869215005195 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215005196 dimer interface [polypeptide binding]; other site 869215005197 conserved gate region; other site 869215005198 ABC-ATPase subunit interface; other site 869215005199 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 869215005200 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 869215005201 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869215005202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215005203 Walker A/P-loop; other site 869215005204 ATP binding site [chemical binding]; other site 869215005205 Q-loop/lid; other site 869215005206 ABC transporter signature motif; other site 869215005207 Walker B; other site 869215005208 D-loop; other site 869215005209 H-loop/switch region; other site 869215005211 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869215005212 Enterocin A Immunity; Region: EntA_Immun; pfam08951 869215005213 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 869215005214 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 869215005215 oligomer interface [polypeptide binding]; other site 869215005216 active site 869215005217 metal binding site [ion binding]; metal-binding site 869215005218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869215005219 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 869215005220 NAD(P) binding site [chemical binding]; other site 869215005221 active site 869215005222 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869215005223 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869215005224 ABC-ATPase subunit interface; other site 869215005225 dimer interface [polypeptide binding]; other site 869215005226 putative PBP binding regions; other site 869215005227 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869215005228 ABC-ATPase subunit interface; other site 869215005229 dimer interface [polypeptide binding]; other site 869215005230 putative PBP binding regions; other site 869215005231 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 869215005232 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869215005233 Walker A/P-loop; other site 869215005234 ATP binding site [chemical binding]; other site 869215005235 Q-loop/lid; other site 869215005236 ABC transporter signature motif; other site 869215005237 Walker B; other site 869215005238 D-loop; other site 869215005239 H-loop/switch region; other site 869215005240 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 869215005241 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 869215005242 putative ligand binding residues [chemical binding]; other site 869215005243 hypothetical protein; Validated; Region: PRK00041 869215005244 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869215005245 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869215005246 RNA binding surface [nucleotide binding]; other site 869215005247 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 869215005248 active site 869215005249 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 869215005250 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 869215005251 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 869215005252 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 869215005253 DNA binding site [nucleotide binding] 869215005254 Int/Topo IB signature motif; other site 869215005255 active site 869215005256 catalytic residues [active] 869215005257 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 869215005258 FOG: CBS domain [General function prediction only]; Region: COG0517 869215005259 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 869215005260 active site 869215005261 metal binding site [ion binding]; metal-binding site 869215005262 homotetramer interface [polypeptide binding]; other site 869215005263 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 869215005264 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 869215005265 active site 869215005266 dimerization interface [polypeptide binding]; other site 869215005267 Glutamate racemase [Cell envelope biogenesis, outer membrane]; Region: MurI; COG0796 869215005268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 869215005269 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 869215005270 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 869215005271 Ca binding site [ion binding]; other site 869215005272 active site 869215005273 catalytic site [active] 869215005274 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 869215005275 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869215005276 active site turn [active] 869215005277 phosphorylation site [posttranslational modification] 869215005278 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869215005279 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 869215005280 HPr interaction site; other site 869215005281 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869215005282 active site 869215005283 phosphorylation site [posttranslational modification] 869215005284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869215005285 DNA-binding site [nucleotide binding]; DNA binding site 869215005286 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 869215005287 UTRA domain; Region: UTRA; pfam07702 869215005289 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 869215005290 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869215005291 Walker A/P-loop; other site 869215005292 ATP binding site [chemical binding]; other site 869215005293 Q-loop/lid; other site 869215005294 ABC transporter signature motif; other site 869215005295 Walker B; other site 869215005296 D-loop; other site 869215005297 H-loop/switch region; other site 869215005298 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 869215005299 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 869215005300 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869215005301 Walker A/P-loop; other site 869215005302 ATP binding site [chemical binding]; other site 869215005303 Q-loop/lid; other site 869215005304 ABC transporter signature motif; other site 869215005305 Walker B; other site 869215005306 D-loop; other site 869215005307 H-loop/switch region; other site 869215005308 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 869215005309 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 869215005310 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 869215005311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215005312 dimer interface [polypeptide binding]; other site 869215005313 conserved gate region; other site 869215005314 putative PBP binding loops; other site 869215005315 ABC-ATPase subunit interface; other site 869215005316 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869215005317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215005318 dimer interface [polypeptide binding]; other site 869215005319 conserved gate region; other site 869215005320 putative PBP binding loops; other site 869215005321 ABC-ATPase subunit interface; other site 869215005322 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869215005323 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869215005324 peptide binding site [polypeptide binding]; other site 869215005325 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 869215005326 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 869215005327 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 869215005328 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 869215005329 active site 869215005330 homodimer interface [polypeptide binding]; other site 869215005331 catalytic site [active] 869215005332 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869215005333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215005334 dimer interface [polypeptide binding]; other site 869215005335 conserved gate region; other site 869215005336 putative PBP binding loops; other site 869215005337 ABC-ATPase subunit interface; other site 869215005338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215005339 dimer interface [polypeptide binding]; other site 869215005340 conserved gate region; other site 869215005341 putative PBP binding loops; other site 869215005342 ABC-ATPase subunit interface; other site 869215005343 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869215005344 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869215005345 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 869215005346 Melibiase; Region: Melibiase; pfam02065 869215005347 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 869215005348 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869215005349 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869215005350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869215005351 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 869215005352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869215005353 DNA-binding site [nucleotide binding]; DNA binding site 869215005354 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 869215005355 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 869215005356 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 869215005357 TRAM domain; Region: TRAM; cl01282 869215005358 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215005359 S-adenosylmethionine binding site [chemical binding]; other site 869215005360 recombination regulator RecX; Provisional; Region: recX; PRK14135 869215005361 hypothetical protein; Provisional; Region: PRK13662 869215005363 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 869215005364 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 869215005365 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 869215005366 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 869215005367 ring oligomerisation interface [polypeptide binding]; other site 869215005368 ATP/Mg binding site [chemical binding]; other site 869215005369 stacking interactions; other site 869215005370 hinge regions; other site 869215005371 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 869215005372 oligomerisation interface [polypeptide binding]; other site 869215005373 mobile loop; other site 869215005374 roof hairpin; other site 869215005375 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869215005376 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869215005377 dimer interface [polypeptide binding]; other site 869215005378 ssDNA binding site [nucleotide binding]; other site 869215005379 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869215005380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869215005381 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 869215005382 NAD(P) binding site [chemical binding]; other site 869215005383 active site 869215005384 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 869215005385 putative tRNA-binding site [nucleotide binding]; other site 869215005386 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869215005387 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869215005388 catalytic residues [active] 869215005389 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 869215005390 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869215005391 LytTr DNA-binding domain; Region: LytTR; pfam04397 869215005392 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 869215005393 active site 869215005394 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869215005395 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047 869215005396 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869215005397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215005398 Walker A/P-loop; other site 869215005399 ATP binding site [chemical binding]; other site 869215005400 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 869215005401 Walker A/P-loop; other site 869215005402 ATP binding site [chemical binding]; other site 869215005403 Q-loop/lid; other site 869215005404 ABC transporter signature motif; other site 869215005405 Walker B; other site 869215005406 D-loop; other site 869215005407 H-loop/switch region; other site 869215005409 MarR family; Region: MarR_2; pfam12802 869215005410 Transcriptional regulators [Transcription]; Region: MarR; COG1846 869215005411 hypothetical protein; Provisional; Region: PRK12378 869215005412 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 869215005413 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 869215005414 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 869215005416 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 869215005417 Domain of unknown function (DUF955); Region: DUF955; cl01076 869215005418 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869215005419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215005420 non-specific DNA binding site [nucleotide binding]; other site 869215005421 salt bridge; other site 869215005422 sequence-specific DNA binding site [nucleotide binding]; other site 869215005423 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869215005424 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 869215005425 amidase catalytic site [active] 869215005426 Zn binding residues [ion binding]; other site 869215005427 substrate binding site [chemical binding]; other site 869215005428 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869215005429 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869215005430 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 869215005431 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 869215005432 recombinase A; Provisional; Region: recA; PRK09354 869215005433 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 869215005434 hexamer interface [polypeptide binding]; other site 869215005435 Walker A motif; other site 869215005436 ATP binding site [chemical binding]; other site 869215005437 Walker B motif; other site 869215005438 competence damage-inducible protein A; Provisional; Region: PRK00549 869215005439 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 869215005440 putative MPT binding site; other site 869215005441 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 869215005442 Transcriptional regulator [Transcription]; Region: LytR; COG1316 869215005443 putative acetyltransferase YhhY; Provisional; Region: PRK10140 869215005444 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869215005445 Coenzyme A binding pocket [chemical binding]; other site 869215005446 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 869215005447 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869215005448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215005449 non-specific DNA binding site [nucleotide binding]; other site 869215005450 salt bridge; other site 869215005451 sequence-specific DNA binding site [nucleotide binding]; other site 869215005452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 869215005453 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 869215005454 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869215005455 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869215005456 Walker A/P-loop; other site 869215005457 ATP binding site [chemical binding]; other site 869215005458 Q-loop/lid; other site 869215005459 ABC transporter signature motif; other site 869215005460 Walker B; other site 869215005461 D-loop; other site 869215005462 H-loop/switch region; other site 869215005463 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 869215005464 active site 869215005465 multimer interface [polypeptide binding]; other site 869215005466 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 869215005467 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 869215005468 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 869215005469 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 869215005470 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 869215005471 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 869215005472 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 869215005473 G-loop; other site 869215005474 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 869215005475 DNA binding site [nucleotide binding] 869215005476 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 869215005477 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 869215005478 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 869215005479 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 869215005480 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 869215005481 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 869215005482 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 869215005483 RPB1 interaction site [polypeptide binding]; other site 869215005484 RPB10 interaction site [polypeptide binding]; other site 869215005485 RPB11 interaction site [polypeptide binding]; other site 869215005486 RPB3 interaction site [polypeptide binding]; other site 869215005487 RPB12 interaction site [polypeptide binding]; other site 869215005488 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 869215005489 Domain of unknown function DUF21; Region: DUF21; pfam01595 869215005490 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 869215005491 Transporter associated domain; Region: CorC_HlyC; smart01091 869215005492 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 869215005493 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 869215005494 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 869215005495 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 869215005496 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 869215005497 hinge; other site 869215005498 active site 869215005499 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 869215005500 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 869215005501 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 869215005502 protein binding site [polypeptide binding]; other site 869215005503 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 869215005504 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 869215005505 active site 869215005506 (T/H)XGH motif; other site 869215005507 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 869215005508 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215005509 S-adenosylmethionine binding site [chemical binding]; other site 869215005510 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 869215005511 dimer interface [polypeptide binding]; other site 869215005512 active site 869215005513 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 869215005514 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 869215005515 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 869215005516 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 869215005517 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869215005518 acylphosphatase; Provisional; Region: PRK14434 869215005519 OxaA-like protein precursor; Provisional; Region: PRK02463 869215005520 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 869215005521 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 869215005522 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869215005523 FeS/SAM binding site; other site 869215005524 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 869215005525 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 869215005526 active site 869215005527 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869215005528 substrate binding site [chemical binding]; other site 869215005529 catalytic residues [active] 869215005530 dimer interface [polypeptide binding]; other site 869215005531 pur operon repressor; Provisional; Region: PRK09213 869215005532 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 869215005533 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869215005534 active site 869215005535 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 869215005536 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 869215005537 generic binding surface II; other site 869215005538 generic binding surface I; other site 869215005539 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869215005540 Zn2+ binding site [ion binding]; other site 869215005541 Mg2+ binding site [ion binding]; other site 869215005542 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 869215005543 RmuC family; Region: RmuC; pfam02646 869215005544 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 869215005545 Thiamine pyrophosphokinase; Region: TPK; cd07995 869215005546 active site 869215005547 dimerization interface [polypeptide binding]; other site 869215005548 thiamine binding site [chemical binding]; other site 869215005549 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 869215005550 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 869215005551 substrate binding site [chemical binding]; other site 869215005552 hexamer interface [polypeptide binding]; other site 869215005553 metal binding site [ion binding]; metal-binding site 869215005554 GTPase RsgA; Reviewed; Region: PRK00098 869215005555 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 869215005556 RNA binding site [nucleotide binding]; other site 869215005557 homodimer interface [polypeptide binding]; other site 869215005558 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 869215005559 GTPase/Zn-binding domain interface [polypeptide binding]; other site 869215005560 GTP/Mg2+ binding site [chemical binding]; other site 869215005561 G4 box; other site 869215005562 G5 box; other site 869215005563 G1 box; other site 869215005564 Switch I region; other site 869215005565 G2 box; other site 869215005566 G3 box; other site 869215005567 Switch II region; other site 869215005568 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 869215005569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215005570 S-adenosylmethionine binding site [chemical binding]; other site 869215005571 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869215005572 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869215005573 Walker A/P-loop; other site 869215005574 ATP binding site [chemical binding]; other site 869215005575 Q-loop/lid; other site 869215005576 ABC transporter signature motif; other site 869215005577 Walker B; other site 869215005578 D-loop; other site 869215005579 H-loop/switch region; other site 869215005580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 869215005581 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 869215005582 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 869215005583 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869215005584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215005585 non-specific DNA binding site [nucleotide binding]; other site 869215005586 salt bridge; other site 869215005587 sequence-specific DNA binding site [nucleotide binding]; other site 869215005588 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 869215005589 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 869215005590 putative active site [active] 869215005591 putative metal binding site [ion binding]; other site 869215005592 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 869215005593 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 869215005594 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 869215005595 active site 869215005596 gene model created manually to include N-terminal signal sequence 869215005597 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 869215005598 aminotransferase AlaT; Validated; Region: PRK09265 869215005599 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869215005600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215005601 homodimer interface [polypeptide binding]; other site 869215005602 catalytic residue [active] 869215005603 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 869215005604 Ligand Binding Site [chemical binding]; other site 869215005605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215005606 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869215005607 active site 869215005608 motif I; other site 869215005609 motif II; other site 869215005610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215005611 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 869215005612 putative nucleotide binding site [chemical binding]; other site 869215005613 putative metal binding site [ion binding]; other site 869215005614 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 869215005615 active site 869215005616 homotetramer interface [polypeptide binding]; other site 869215005617 homodimer interface [polypeptide binding]; other site 869215005618 catabolite control protein A; Region: ccpA; TIGR01481 869215005619 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869215005620 DNA binding site [nucleotide binding] 869215005621 domain linker motif; other site 869215005622 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 869215005623 dimerization interface [polypeptide binding]; other site 869215005624 effector binding site; other site 869215005625 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869215005626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869215005627 active site 869215005628 phosphorylation site [posttranslational modification] 869215005629 intermolecular recognition site; other site 869215005630 dimerization interface [polypeptide binding]; other site 869215005631 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869215005632 DNA binding residues [nucleotide binding] 869215005633 dimerization interface [polypeptide binding]; other site 869215005634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 869215005635 Histidine kinase; Region: HisKA_3; pfam07730 869215005636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215005637 ATP binding site [chemical binding]; other site 869215005638 Mg2+ binding site [ion binding]; other site 869215005639 G-X-G motif; other site 869215005640 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 869215005641 ABC-2 type transporter; Region: ABC2_membrane; cl17235 869215005642 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869215005643 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869215005644 Walker A/P-loop; other site 869215005645 ATP binding site [chemical binding]; other site 869215005646 Q-loop/lid; other site 869215005647 ABC transporter signature motif; other site 869215005648 Walker B; other site 869215005649 D-loop; other site 869215005650 H-loop/switch region; other site 869215005651 manually curated to include N-terminal signal sequence 869215005652 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 869215005653 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 869215005654 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 869215005655 putative homodimer interface [polypeptide binding]; other site 869215005656 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 869215005657 heterodimer interface [polypeptide binding]; other site 869215005658 homodimer interface [polypeptide binding]; other site 869215005659 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 869215005660 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 869215005661 Transglycosylase; Region: Transgly; pfam00912 869215005662 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869215005663 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869215005664 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869215005665 active site 869215005666 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 869215005667 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 869215005668 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 869215005669 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 869215005670 FtsX-like permease family; Region: FtsX; pfam02687 869215005672 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559 869215005673 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 869215005674 dimerization interface [polypeptide binding]; other site 869215005675 active site 869215005676 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 869215005677 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869215005679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 869215005680 Walker A/P-loop; other site 869215005681 ATP binding site [chemical binding]; other site 869215005682 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869215005683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869215005684 DNA-binding site [nucleotide binding]; DNA binding site 869215005685 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 869215005686 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 869215005687 beta-galactosidase; Region: BGL; TIGR03356 869215005688 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869215005689 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 869215005690 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 869215005691 active site 869215005692 P-loop; other site 869215005693 phosphorylation site [posttranslational modification] 869215005694 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869215005695 methionine cluster; other site 869215005696 active site 869215005697 phosphorylation site [posttranslational modification] 869215005698 metal binding site [ion binding]; metal-binding site 869215005699 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 869215005700 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 869215005701 putative catalytic cysteine [active] 869215005702 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 869215005703 putative active site [active] 869215005704 metal binding site [ion binding]; metal-binding site 869215005705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 869215005706 MORN repeat; Region: MORN; cl14787 869215005707 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 869215005708 Low molecular weight phosphatase family; Region: LMWPc; cd00115 869215005709 active site 869215005710 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 869215005711 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 869215005712 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869215005713 TPP-binding site [chemical binding]; other site 869215005714 dimer interface [polypeptide binding]; other site 869215005715 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869215005716 PYR/PP interface [polypeptide binding]; other site 869215005717 dimer interface [polypeptide binding]; other site 869215005718 TPP binding site [chemical binding]; other site 869215005719 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869215005720 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 869215005721 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 869215005722 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869215005723 PRD domain; Region: PRD; pfam00874 869215005724 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869215005725 active site 869215005726 P-loop; other site 869215005727 phosphorylation site [posttranslational modification] 869215005728 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 869215005729 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 869215005730 intersubunit interface [polypeptide binding]; other site 869215005731 active site 869215005732 Zn2+ binding site [ion binding]; other site 869215005733 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 869215005734 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 869215005735 AP (apurinic/apyrimidinic) site pocket; other site 869215005736 DNA interaction; other site 869215005737 Metal-binding active site; metal-binding site 869215005738 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 869215005739 active site 869215005740 dimer interface [polypeptide binding]; other site 869215005741 magnesium binding site [ion binding]; other site 869215005742 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869215005743 active site 869215005744 phosphorylation site [posttranslational modification] 869215005745 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 869215005746 active site 869215005747 P-loop; other site 869215005748 phosphorylation site [posttranslational modification] 869215005749 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 869215005750 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 869215005751 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 869215005752 G-X-X-G motif; other site 869215005753 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 869215005754 RxxxH motif; other site 869215005755 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 869215005756 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 869215005757 ribonuclease P; Reviewed; Region: rnpA; PRK00499 869215005758 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 869215005759 propionate/acetate kinase; Provisional; Region: PRK12379 869215005760 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 869215005761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215005762 S-adenosylmethionine binding site [chemical binding]; other site 869215005764 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 869215005765 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 869215005766 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 869215005767 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 869215005768 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 869215005769 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 869215005770 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 869215005771 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869215005772 Walker A motif; other site 869215005773 ATP binding site [chemical binding]; other site 869215005774 Walker B motif; other site 869215005775 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 869215005776 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 869215005777 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869215005778 catalytic Zn binding site [ion binding]; other site 869215005779 structural Zn binding site [ion binding]; other site 869215005780 NAD(P) binding site [chemical binding]; other site 869215005781 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 869215005782 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 869215005783 active site 869215005784 dimer interface [polypeptide binding]; other site 869215005785 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 869215005786 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 869215005787 catalytic triad [active] 869215005788 catalytic triad [active] 869215005789 oxyanion hole [active] 869215005790 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 869215005791 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 869215005792 Predicted integral membrane protein [Function unknown]; Region: COG5523 869215005794 Predicted membrane protein [Function unknown]; Region: COG3759 869215005795 Transcriptional regulators [Transcription]; Region: MarR; COG1846 869215005796 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869215005797 putative DNA binding site [nucleotide binding]; other site 869215005798 putative Zn2+ binding site [ion binding]; other site 869215005799 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869215005800 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 869215005801 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215005802 motif II; other site 869215005803 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 869215005804 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 869215005805 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 869215005806 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 869215005807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215005808 catalytic residue [active] 869215005809 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 869215005810 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 869215005811 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869215005812 active site 869215005813 HIGH motif; other site 869215005814 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869215005815 active site 869215005816 KMSKS motif; other site 869215005817 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 869215005818 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 869215005819 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 869215005820 active site 869215005821 dimer interface [polypeptide binding]; other site 869215005822 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 869215005823 dimer interface [polypeptide binding]; other site 869215005824 active site 869215005825 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 869215005826 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 869215005827 catalytic triad [active] 869215005828 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869215005829 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869215005830 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215005831 Walker A/P-loop; other site 869215005832 ATP binding site [chemical binding]; other site 869215005833 Q-loop/lid; other site 869215005834 ABC transporter signature motif; other site 869215005835 Walker B; other site 869215005836 D-loop; other site 869215005837 H-loop/switch region; other site 869215005839 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869215005840 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869215005841 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215005842 Walker A/P-loop; other site 869215005843 ATP binding site [chemical binding]; other site 869215005844 Q-loop/lid; other site 869215005845 ABC transporter signature motif; other site 869215005846 Walker B; other site 869215005847 D-loop; other site 869215005848 H-loop/switch region; other site 869215005849 DNA mismatch repair protein MutS; Region: mutS1; TIGR01070 869215005850 MutS domain I; Region: MutS_I; pfam01624 869215005851 MutS domain II; Region: MutS_II; pfam05188 869215005852 MutS domain III; Region: MutS_III; pfam05192 869215005853 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 869215005854 Walker A/P-loop; other site 869215005855 ATP binding site [chemical binding]; other site 869215005856 Q-loop/lid; other site 869215005857 ABC transporter signature motif; other site 869215005858 Walker B; other site 869215005859 D-loop; other site 869215005860 H-loop/switch region; other site 869215005861 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869215005862 arginine repressor; Region: argR_whole; TIGR01529 869215005863 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869215005864 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 869215005865 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 869215005866 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 869215005867 active site 869215005868 HIGH motif; other site 869215005869 KMSK motif region; other site 869215005870 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 869215005871 tRNA binding surface [nucleotide binding]; other site 869215005872 anticodon binding site; other site 869215005874 Uncharacterized conserved protein [Function unknown]; Region: COG3542 869215005875 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869215005876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869215005877 active site 869215005878 phosphorylation site [posttranslational modification] 869215005879 intermolecular recognition site; other site 869215005880 dimerization interface [polypeptide binding]; other site 869215005881 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869215005882 DNA binding site [nucleotide binding] 869215005883 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 869215005884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869215005885 dimer interface [polypeptide binding]; other site 869215005886 phosphorylation site [posttranslational modification] 869215005887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215005888 ATP binding site [chemical binding]; other site 869215005889 G-X-G motif; other site 869215005890 PBP superfamily domain; Region: PBP_like_2; cl17296 869215005891 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 869215005892 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 869215005893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215005894 dimer interface [polypeptide binding]; other site 869215005895 conserved gate region; other site 869215005896 putative PBP binding loops; other site 869215005897 ABC-ATPase subunit interface; other site 869215005898 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 869215005899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215005900 dimer interface [polypeptide binding]; other site 869215005901 conserved gate region; other site 869215005902 putative PBP binding loops; other site 869215005903 ABC-ATPase subunit interface; other site 869215005904 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 869215005905 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869215005906 Walker A/P-loop; other site 869215005907 ATP binding site [chemical binding]; other site 869215005908 Q-loop/lid; other site 869215005909 ABC transporter signature motif; other site 869215005910 Walker B; other site 869215005911 D-loop; other site 869215005912 H-loop/switch region; other site 869215005913 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 869215005914 PhoU domain; Region: PhoU; pfam01895 869215005915 PhoU domain; Region: PhoU; pfam01895 869215005917 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869215005918 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215005919 non-specific DNA binding site [nucleotide binding]; other site 869215005920 salt bridge; other site 869215005921 sequence-specific DNA binding site [nucleotide binding]; other site 869215005922 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 869215005923 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 869215005924 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 869215005925 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 869215005926 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 869215005927 active site 869215005928 tetramer interface; other site 869215005929 Rhomboid family; Region: Rhomboid; pfam01694 869215005930 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 869215005931 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 869215005932 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 869215005933 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 869215005934 metal binding site [ion binding]; metal-binding site 869215005935 putative dimer interface [polypeptide binding]; other site 869215005936 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 869215005937 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 869215005938 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 869215005939 trimer interface [polypeptide binding]; other site 869215005940 active site 869215005941 substrate binding site [chemical binding]; other site 869215005942 CoA binding site [chemical binding]; other site 869215005943 EamA-like transporter family; Region: EamA; pfam00892 869215005944 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 869215005945 Transglycosylase; Region: Transgly; pfam00912 869215005946 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869215005947 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 869215005948 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 869215005949 active site 869215005950 HIGH motif; other site 869215005951 dimer interface [polypeptide binding]; other site 869215005952 KMSKS motif; other site 869215005953 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869215005954 RNA binding surface [nucleotide binding]; other site 869215005955 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 869215005956 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869215005957 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869215005958 motif II; other site 869215005959 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 869215005960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869215005961 S-adenosylmethionine binding site [chemical binding]; other site 869215005962 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 869215005963 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869215005964 4-alpha-glucanotransferase; Provisional; Region: PRK14508 869215005965 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 869215005966 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869215005967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215005968 dimer interface [polypeptide binding]; other site 869215005969 conserved gate region; other site 869215005970 putative PBP binding loops; other site 869215005971 ABC-ATPase subunit interface; other site 869215005972 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869215005973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215005974 dimer interface [polypeptide binding]; other site 869215005975 conserved gate region; other site 869215005976 putative PBP binding loops; other site 869215005977 ABC-ATPase subunit interface; other site 869215005978 Predicted integral membrane protein [Function unknown]; Region: COG5521 869215005979 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869215005980 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869215005981 DNA binding site [nucleotide binding] 869215005982 domain linker motif; other site 869215005983 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 869215005984 putative dimerization interface [polypeptide binding]; other site 869215005985 putative ligand binding site [chemical binding]; other site 869215005986 Uncharacterized conserved protein [Function unknown]; Region: COG1284 869215005987 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869215005988 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869215005989 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 869215005990 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 869215005991 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 869215005992 dimer interface [polypeptide binding]; other site 869215005993 anticodon binding site; other site 869215005994 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869215005995 homodimer interface [polypeptide binding]; other site 869215005996 motif 1; other site 869215005997 active site 869215005998 motif 2; other site 869215005999 GAD domain; Region: GAD; pfam02938 869215006000 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869215006001 motif 3; other site 869215006002 CAAX protease self-immunity; Region: Abi; pfam02517 869215006003 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 869215006004 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215006005 non-specific DNA binding site [nucleotide binding]; other site 869215006006 salt bridge; other site 869215006007 sequence-specific DNA binding site [nucleotide binding]; other site 869215006008 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 869215006009 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 869215006010 dimer interface [polypeptide binding]; other site 869215006011 motif 1; other site 869215006012 active site 869215006013 motif 2; other site 869215006014 motif 3; other site 869215006015 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 869215006016 anticodon binding site; other site 869215006017 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869215006018 non-specific DNA binding site [nucleotide binding]; other site 869215006019 salt bridge; other site 869215006020 sequence-specific DNA binding site [nucleotide binding]; other site 869215006021 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869215006022 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 869215006023 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 869215006024 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 869215006025 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869215006026 PYR/PP interface [polypeptide binding]; other site 869215006027 dimer interface [polypeptide binding]; other site 869215006028 TPP binding site [chemical binding]; other site 869215006029 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869215006030 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869215006031 TPP-binding site [chemical binding]; other site 869215006032 dimer interface [polypeptide binding]; other site 869215006033 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 869215006034 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 869215006035 active site 869215006036 P-loop; other site 869215006037 phosphorylation site [posttranslational modification] 869215006038 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869215006039 PRD domain; Region: PRD; pfam00874 869215006040 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869215006041 active site 869215006042 P-loop; other site 869215006043 phosphorylation site [posttranslational modification] 869215006044 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869215006045 active site 869215006046 phosphorylation site [posttranslational modification] 869215006047 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 869215006048 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 869215006049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 869215006050 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 869215006051 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 869215006052 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 869215006053 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 869215006054 putative active site [active] 869215006055 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869215006056 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869215006057 nucleotide binding site [chemical binding]; other site 869215006058 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 869215006059 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 869215006060 active site 869215006061 metal binding site [ion binding]; metal-binding site 869215006062 homodimer interface [polypeptide binding]; other site 869215006063 catalytic site [active] 869215006064 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 869215006065 Uncharacterized conserved protein [Function unknown]; Region: COG3538 869215006066 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 869215006067 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 869215006068 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 869215006069 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 869215006070 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 869215006071 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869215006072 arginine deiminase; Provisional; Region: PRK01388 869215006073 ornithine carbamoyltransferase; Validated; Region: PRK02102 869215006074 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869215006075 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869215006076 carbamate kinase; Reviewed; Region: PRK12686 869215006077 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 869215006078 putative substrate binding site [chemical binding]; other site 869215006079 nucleotide binding site [chemical binding]; other site 869215006080 nucleotide binding site [chemical binding]; other site 869215006081 homodimer interface [polypeptide binding]; other site 869215006082 Predicted membrane protein [Function unknown]; Region: COG1288 869215006083 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 869215006084 hypothetical protein; Provisional; Region: PRK07205 869215006085 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 869215006086 active site 869215006087 metal binding site [ion binding]; metal-binding site 869215006090 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 869215006091 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 869215006092 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 869215006093 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 869215006094 dimer interface [polypeptide binding]; other site 869215006095 active site 869215006096 metal binding site [ion binding]; metal-binding site 869215006097 L-fucose isomerase; Provisional; Region: fucI; PRK10991 869215006098 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 869215006099 hexamer (dimer of trimers) interface [polypeptide binding]; other site 869215006100 trimer interface [polypeptide binding]; other site 869215006101 substrate binding site [chemical binding]; other site 869215006102 Mn binding site [ion binding]; other site 869215006103 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 869215006104 intersubunit interface [polypeptide binding]; other site 869215006105 active site 869215006106 Zn2+ binding site [ion binding]; other site 869215006107 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 869215006108 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 869215006109 Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306 869215006110 Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307 869215006111 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 869215006112 Melibiase; Region: Melibiase; pfam02065 869215006113 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 869215006114 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 869215006115 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 869215006116 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869215006117 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215006118 dimer interface [polypeptide binding]; other site 869215006119 conserved gate region; other site 869215006120 putative PBP binding loops; other site 869215006121 ABC-ATPase subunit interface; other site 869215006122 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869215006123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869215006124 dimer interface [polypeptide binding]; other site 869215006125 conserved gate region; other site 869215006126 putative PBP binding loops; other site 869215006127 ABC-ATPase subunit interface; other site 869215006128 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869215006129 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869215006130 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 869215006131 N- and C-terminal domain interface [polypeptide binding]; other site 869215006132 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 869215006133 active site 869215006134 putative catalytic site [active] 869215006135 metal binding site [ion binding]; metal-binding site 869215006136 ATP binding site [chemical binding]; other site 869215006137 carbohydrate binding site [chemical binding]; other site 869215006138 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869215006139 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 869215006140 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869215006141 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869215006142 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 869215006143 metal binding site [ion binding]; metal-binding site 869215006144 YodA lipocalin-like domain; Region: YodA; pfam09223 869215006145 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 869215006146 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869215006147 ABC-ATPase subunit interface; other site 869215006148 dimer interface [polypeptide binding]; other site 869215006149 putative PBP binding regions; other site 869215006150 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869215006151 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 869215006152 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869215006153 putative DNA binding site [nucleotide binding]; other site 869215006154 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 869215006155 DltD N-terminal region; Region: DltD_N; pfam04915 869215006156 DltD central region; Region: DltD_M; pfam04918 869215006157 DltD C-terminal region; Region: DltD_C; pfam04914 869215006158 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 869215006159 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 869215006160 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 869215006161 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 869215006162 acyl-activating enzyme (AAE) consensus motif; other site 869215006163 AMP binding site [chemical binding]; other site 869215006164 H+ Antiporter protein; Region: 2A0121; TIGR00900 869215006165 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 869215006166 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 869215006167 putative active site [active] 869215006168 putative NTP binding site [chemical binding]; other site 869215006169 putative nucleic acid binding site [nucleotide binding]; other site 869215006170 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 869215006171 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 869215006172 amphipathic channel; other site 869215006173 Asn-Pro-Ala signature motifs; other site 869215006174 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 869215006175 glycerol kinase; Provisional; Region: glpK; PRK00047 869215006176 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 869215006177 N- and C-terminal domain interface [polypeptide binding]; other site 869215006178 active site 869215006179 MgATP binding site [chemical binding]; other site 869215006180 catalytic site [active] 869215006181 metal binding site [ion binding]; metal-binding site 869215006182 glycerol binding site [chemical binding]; other site 869215006183 homotetramer interface [polypeptide binding]; other site 869215006184 homodimer interface [polypeptide binding]; other site 869215006185 FBP binding site [chemical binding]; other site 869215006186 protein IIAGlc interface [polypeptide binding]; other site 869215006187 Mga helix-turn-helix domain; Region: Mga; pfam05043 869215006188 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 869215006189 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 869215006190 dimerization interface [polypeptide binding]; other site 869215006191 domain crossover interface; other site 869215006192 redox-dependent activation switch; other site 869215006193 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 869215006194 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 869215006195 FMN binding site [chemical binding]; other site 869215006196 active site 869215006197 catalytic residues [active] 869215006198 substrate binding site [chemical binding]; other site 869215006199 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869215006200 RICH domain; Region: RICH; pfam05062 869215006201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 869215006202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869215006203 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869215006204 dimerization interface [polypeptide binding]; other site 869215006205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869215006206 dimer interface [polypeptide binding]; other site 869215006207 phosphorylation site [posttranslational modification] 869215006208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869215006209 ATP binding site [chemical binding]; other site 869215006210 Mg2+ binding site [ion binding]; other site 869215006211 G-X-G motif; other site 869215006212 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869215006213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869215006214 active site 869215006215 phosphorylation site [posttranslational modification] 869215006216 intermolecular recognition site; other site 869215006217 dimerization interface [polypeptide binding]; other site 869215006218 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869215006219 DNA binding site [nucleotide binding] 869215006220 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 869215006221 Clp amino terminal domain; Region: Clp_N; pfam02861 869215006222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215006223 Walker A motif; other site 869215006224 ATP binding site [chemical binding]; other site 869215006225 Walker B motif; other site 869215006226 arginine finger; other site 869215006227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869215006228 Walker A motif; other site 869215006229 ATP binding site [chemical binding]; other site 869215006230 Walker B motif; other site 869215006231 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869215006232 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 869215006233 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 869215006234 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 869215006235 Walker A/P-loop; other site 869215006236 ATP binding site [chemical binding]; other site 869215006237 Q-loop/lid; other site 869215006238 ABC transporter signature motif; other site 869215006239 Walker B; other site 869215006240 D-loop; other site 869215006241 H-loop/switch region; other site 869215006242 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 869215006243 NMT1/THI5 like; Region: NMT1; pfam09084 869215006244 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 869215006245 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 869215006246 Uncharacterized conserved protein [Function unknown]; Region: COG0011 869215006247 Surface antigen [General function prediction only]; Region: COG3942 869215006248 CHAP domain; Region: CHAP; pfam05257 869215006249 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869215006250 Bacterial SH3 domain; Region: SH3_5; pfam08460 869215006251 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869215006252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 869215006253 replicative DNA helicase; Provisional; Region: PRK05748 869215006254 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 869215006255 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 869215006256 Walker A motif; other site 869215006257 ATP binding site [chemical binding]; other site 869215006258 Walker B motif; other site 869215006259 DNA binding loops [nucleotide binding] 869215006260 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 869215006261 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 869215006262 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 869215006263 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 869215006264 DHH family; Region: DHH; pfam01368 869215006265 DHHA1 domain; Region: DHHA1; pfam02272 869215006266 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 869215006267 30S subunit binding site; other site 869215006268 comF family protein; Region: comF; TIGR00201 869215006269 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869215006270 active site 869215006271 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 869215006272 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869215006273 ATP binding site [chemical binding]; other site 869215006274 putative Mg++ binding site [ion binding]; other site 869215006275 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869215006276 nucleotide binding region [chemical binding]; other site 869215006277 ATP-binding site [chemical binding]; other site 869215006278 Uncharacterized conserved protein [Function unknown]; Region: COG1739 869215006279 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 869215006280 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 869215006281 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 869215006282 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 869215006283 dimer interface [polypeptide binding]; other site 869215006284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869215006285 catalytic residue [active] 869215006289 elongation factor Ts; Provisional; Region: tsf; PRK09377 869215006290 UBA/TS-N domain; Region: UBA; pfam00627 869215006291 Elongation factor TS; Region: EF_TS; pfam00889 869215006292 Elongation factor TS; Region: EF_TS; pfam00889 869215006293 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 869215006294 rRNA interaction site [nucleotide binding]; other site 869215006295 S8 interaction site; other site 869215006296 putative laminin-1 binding site; other site 869215006297 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 869215006298 Septum formation initiator; Region: DivIC; cl17659 869215006299 Surface antigen [General function prediction only]; Region: COG3942 869215006300 CHAP domain; Region: CHAP; pfam05257 869215006301 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 869215006302 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 869215006303 rod shape-determining protein MreC; Region: MreC; pfam04085 869215006304 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869215006305 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 869215006306 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869215006307 Walker A/P-loop; other site 869215006308 ATP binding site [chemical binding]; other site 869215006309 Q-loop/lid; other site 869215006310 ABC transporter signature motif; other site 869215006311 Walker B; other site 869215006312 D-loop; other site 869215006313 H-loop/switch region; other site 869215006314 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 869215006315 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869215006316 Walker A/P-loop; other site 869215006317 ATP binding site [chemical binding]; other site 869215006318 Q-loop/lid; other site 869215006319 ABC transporter signature motif; other site 869215006320 Walker B; other site 869215006321 D-loop; other site 869215006322 H-loop/switch region; other site 869215006323 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 869215006324 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 869215006325 Helix-turn-helix domain; Region: HTH_25; pfam13413 869215006326 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 869215006327 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869215006328 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 869215006329 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869215006330 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869215006331 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869215006332 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 869215006333 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 869215006334 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 869215006335 Walker A/P-loop; other site 869215006336 ATP binding site [chemical binding]; other site 869215006337 Q-loop/lid; other site 869215006338 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869215006339 ABC transporter signature motif; other site 869215006340 Walker B; other site 869215006341 D-loop; other site 869215006342 H-loop/switch region; other site 869215006343 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 869215006344 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869215006345 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 869215006346 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869215006347 active site 869215006348 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 869215006349 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 869215006350 active site 869215006351 HIGH motif; other site 869215006352 dimer interface [polypeptide binding]; other site 869215006353 KMSKS motif; other site 869215006354 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 869215006355 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869215006356 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869215006357 ABC transporter; Region: ABC_tran_2; pfam12848 869215006358 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869215006359 Predicted membrane protein [Function unknown]; Region: COG4485 869215006360 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 869215006361 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 869215006362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869215006363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869215006364 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869215006365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869215006366 active site 869215006367 phosphorylation site [posttranslational modification] 869215006368 intermolecular recognition site; other site 869215006369 dimerization interface [polypeptide binding]; other site 869215006370 LytTr DNA-binding domain; Region: LytTR; pfam04397 869215006371 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869215006372 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 869215006373 COMC family; Region: ComC; pfam03047 869215006374 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 869215006375 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 869215006376 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869215006377 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869215006378 protein binding site [polypeptide binding]; other site 869215006379 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 869215006380 ParB-like nuclease domain; Region: ParBc; pfam02195 869215006381 KorB domain; Region: KorB; pfam08535