-- dump date 20140620_084859 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 488223000001 SEQ_END SEQ_END NC_012467.1 2111882 2111882 DR NC_012467.1; contig end 2111882..2111882 Streptococcus pneumoniae P1031 YP_002737247.1 CDS dnaA NC_012467.1 197 1558 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 197..1558 Streptococcus pneumoniae P1031 7680774 YP_002737248.1 CDS dnaN NC_012467.1 1717 2853 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1717..2853 Streptococcus pneumoniae P1031 7681661 YP_002737249.1 CDS SPP_0003 NC_012467.1 2918 3112 D identified by match to protein family HMM PF06107; hypothetical protein 2918..3112 Streptococcus pneumoniae P1031 7681640 YP_002737250.1 CDS ychF NC_012467.1 3196 4311 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 3196..4311 Streptococcus pneumoniae P1031 7681839 YP_002737251.1 CDS pth NC_012467.1 4382 4951 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4382..4951 Streptococcus pneumoniae P1031 7680775 YP_002737252.1 CDS mfd NC_012467.1 4952 8461 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580; transcription-repair coupling factor 4952..8461 Streptococcus pneumoniae P1031 7681404 YP_002737253.1 CDS SPP_0007 NC_012467.1 8519 8785 D identified by match to protein family HMM PF01479; ribosome-associated heat shock protein implicated in the recycling of the 50S subunit 8519..8785 Streptococcus pneumoniae P1031 7682584 YP_002737254.1 CDS SPP_0008 NC_012467.1 8778 9146 D identified by match to protein family HMM PF04977; septum formation initiator 8778..9146 Streptococcus pneumoniae P1031 7682001 YP_002737255.1 CDS SPP_0009 NC_012467.1 9151 9273 D hypothetical protein 9151..9273 Streptococcus pneumoniae P1031 7682200 YP_002737256.1 CDS SPP_0010 NC_012467.1 9266 10534 D beta-lactamase class A 9266..10534 Streptococcus pneumoniae P1031 7681580 YP_002737257.1 CDS SPP_0011 NC_012467.1 10531 11808 D identified by match to protein family HMM PF01171; match to protein family HMM TIGR02432; match to protein family HMM TIGR02433; tRNA(Ile)-lysidine synthase (tRNA(Ile)-lysidinesynthetase) (tRNA(Ile)-2-lysyl-cytidine synthase) 10531..11808 Streptococcus pneumoniae P1031 7681887 YP_002737258.1 CDS hpt NC_012467.1 11812 12354 D identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; hypoxanthine phosphoribosyltransferase 11812..12354 Streptococcus pneumoniae P1031 7681100 YP_002737259.1 CDS hflB NC_012467.1 12370 14328 D identified by match to protein family HMM PF00004; match to protein family HMM PF01434; match to protein family HMM PF06480; match to protein family HMM TIGR01241; ATP-dependent metallopeptidase HflB 12370..14328 Streptococcus pneumoniae P1031 7681019 YP_002737260.1 CDS SPP_0014 NC_012467.1 14450 14929 D competence-specific global transcription modulator 14450..14929 Streptococcus pneumoniae P1031 7682022 YP_002737261.1 CDS SPP_0022 NC_012467.1 20422 20751 D identified by match to protein family HMM PF01710; transposase 20422..20751 Streptococcus pneumoniae P1031 7680750 YP_002737262.1 CDS SPP_0023 NC_012467.1 21178 21312 D identified by glimmer; putative; hypothetical protein 21178..21312 Streptococcus pneumoniae P1031 7681697 YP_002737263.1 CDS SPP_0026 NC_012467.1 22365 22601 D hypothetical protein 22365..22601 Streptococcus pneumoniae P1031 7681890 YP_002737264.1 CDS purA NC_012467.1 22790 24118 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 22790..24118 Streptococcus pneumoniae P1031 7682486 YP_002737265.1 CDS SPP_0028 NC_012467.1 24350 25498 R identified by match to protein family HMM PF00589; integrase complement(24350..25498) Streptococcus pneumoniae P1031 7681563 YP_002737266.1 CDS SPP_0029 NC_012467.1 25673 26485 R identified by glimmer; putative; hypothetical protein complement(25673..26485) Streptococcus pneumoniae P1031 7681879 YP_002737267.1 CDS SPP_0030 NC_012467.1 26523 26669 R identified by glimmer; putative; hypothetical protein complement(26523..26669) Streptococcus pneumoniae P1031 7681590 YP_002737268.1 CDS SPP_0031 NC_012467.1 26745 26903 R identified by glimmer; putative; hypothetical protein complement(26745..26903) Streptococcus pneumoniae P1031 7681286 YP_002737269.1 CDS SPP_0032 NC_012467.1 26916 27179 R identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; plasmid addiction system poison protein complement(26916..27179) Streptococcus pneumoniae P1031 7681812 YP_002737270.1 CDS SPP_0033 NC_012467.1 27179 27412 R hypothetical protein complement(27179..27412) Streptococcus pneumoniae P1031 7681314 YP_002737271.1 CDS SPP_0034 NC_012467.1 27412 27780 R identified by match to protein family HMM PF01381; phage transcriptional regulator, Cro/CI family complement(27412..27780) Streptococcus pneumoniae P1031 7682696 YP_002737272.1 CDS SPP_0035 NC_012467.1 28065 28211 D hypothetical protein 28065..28211 Streptococcus pneumoniae P1031 7680973 YP_002737273.1 CDS SPP_0036 NC_012467.1 28622 28825 D hypothetical protein 28622..28825 Streptococcus pneumoniae P1031 7682205 YP_002737274.1 CDS SPP_0037 NC_012467.1 28842 29039 D hypothetical protein 28842..29039 Streptococcus pneumoniae P1031 7682785 YP_002737275.1 CDS SPP_0038 NC_012467.1 29206 29631 R phage protein, putative complement(29206..29631) Streptococcus pneumoniae P1031 7681737 YP_002737276.1 CDS SPP_0039 NC_012467.1 29685 30398 D identified by match to protein family HMM PF02498; gp15 29685..30398 Streptococcus pneumoniae P1031 7681222 YP_002737277.1 CDS SPP_0040 NC_012467.1 30411 30668 D phage protein 30411..30668 Streptococcus pneumoniae P1031 7681000 YP_002737278.1 CDS SPP_0041 NC_012467.1 30754 31074 D hypothetical protein 30754..31074 Streptococcus pneumoniae P1031 7682313 YP_002737279.1 CDS SPP_0042 NC_012467.1 31090 31386 D gp18 31090..31386 Streptococcus pneumoniae P1031 7681495 YP_002737280.1 CDS SPP_0043 NC_012467.1 31370 32206 D identified by match to protein family HMM PF04271; match to protein family HMM TIGR01446; match to protein family HMM TIGR01714; gp19 31370..32206 Streptococcus pneumoniae P1031 7682575 YP_002737281.1 CDS SPP_0044 NC_012467.1 32194 32352 D hypothetical protein 32194..32352 Streptococcus pneumoniae P1031 7682287 YP_002737282.1 CDS SPP_0045 NC_012467.1 32475 33116 D gp21 32475..33116 Streptococcus pneumoniae P1031 7682161 YP_002737283.1 CDS SPP_0046 NC_012467.1 33131 33325 D identified by glimmer; putative; hypothetical protein 33131..33325 Streptococcus pneumoniae P1031 7682035 YP_002737284.1 CDS SPP_0047 NC_012467.1 33325 33552 D hypothetical protein 33325..33552 Streptococcus pneumoniae P1031 7680670 YP_002737285.1 CDS SPP_0048 NC_012467.1 33679 33846 D identified by glimmer; putative; hypothetical protein 33679..33846 Streptococcus pneumoniae P1031 7681167 YP_002737286.1 CDS SPP_0049 NC_012467.1 34014 34343 D gp24 34014..34343 Streptococcus pneumoniae P1031 7682504 YP_002737287.1 CDS SPP_0050 NC_012467.1 34333 34758 D identified by match to protein family HMM PF07852; hypothetical protein 34333..34758 Streptococcus pneumoniae P1031 7682379 YP_002737288.1 CDS SPP_0053 NC_012467.1 35314 35658 D identified by match to protein family HMM TIGR01671; hypothetical protein 35314..35658 Streptococcus pneumoniae P1031 7681505 YP_002737289.1 CDS SPP_0054 NC_012467.1 35658 35894 D gp29 35658..35894 Streptococcus pneumoniae P1031 7682603 YP_002737290.1 CDS SPP_0055 NC_012467.1 35906 36049 D identified by glimmer; putative; hypothetical protein 35906..36049 Streptococcus pneumoniae P1031 7681500 YP_002737291.1 CDS SPP_0056 NC_012467.1 36851 37393 D identified by match to protein family HMM PF00589; prophage LambdaSa2, site-specific recombinase, phage integrase family 36851..37393 Streptococcus pneumoniae P1031 7682177 YP_002737292.1 CDS SPP_0057 NC_012467.1 37557 37748 D identified by glimmer; putative; hypothetical protein 37557..37748 Streptococcus pneumoniae P1031 7681466 YP_002737293.1 CDS SPP_0058 NC_012467.1 37868 38188 D hypothetical protein 37868..38188 Streptococcus pneumoniae P1031 7682703 YP_002737294.1 CDS SPP_0059 NC_012467.1 38326 38718 D hypothetical protein 38326..38718 Streptococcus pneumoniae P1031 7681160 YP_002737295.1 CDS SPP_0060 NC_012467.1 38711 40441 D identified by match to protein family HMM PF03354; putative phage terminase, large subunit 38711..40441 Streptococcus pneumoniae P1031 7681668 YP_002737296.1 CDS SPP_0061 NC_012467.1 40449 40667 D identified by glimmer; putative; hypothetical protein 40449..40667 Streptococcus pneumoniae P1031 7682250 YP_002737297.1 CDS SPP_0062 NC_012467.1 40685 41887 D identified by match to protein family HMM PF04860; match to protein family HMM TIGR01537; phage portal protein, HK97 family 40685..41887 Streptococcus pneumoniae P1031 7682692 YP_002737298.1 CDS SPP_0063 NC_012467.1 41871 42446 D identified by match to protein family HMM PF04586; match to protein family HMM TIGR01543; phage prohead protease, HK97 family 41871..42446 Streptococcus pneumoniae P1031 7680811 YP_002737299.1 CDS SPP_0064 NC_012467.1 42443 43615 D identified by match to protein family HMM PF05065; match to protein family HMM TIGR01554; phage major capsid protein, HK97 family 42443..43615 Streptococcus pneumoniae P1031 7681194 YP_002737300.1 CDS SPP_0065 NC_012467.1 43627 43917 D hypothetical protein 43627..43917 Streptococcus pneumoniae P1031 7680985 YP_002737301.1 CDS SPP_0066 NC_012467.1 43920 44201 D hypothetical protein 43920..44201 Streptococcus pneumoniae P1031 7682834 YP_002737302.1 CDS SPP_0067 NC_012467.1 44188 44487 D identified by match to protein family HMM TIGR01563; phage head-tail adaptor, putative 44188..44487 Streptococcus pneumoniae P1031 7682182 YP_002737303.1 CDS SPP_0068 NC_012467.1 44484 44831 D prophage pi2 protein 37 44484..44831 Streptococcus pneumoniae P1031 7682138 YP_002737304.1 CDS SPP_0069 NC_012467.1 44828 45151 D hypothetical protein 44828..45151 Streptococcus pneumoniae P1031 7682582 YP_002737305.1 CDS SPP_0070 NC_012467.1 45163 45741 D identified by match to protein family HMM TIGR01603; prophage pi2 protein 39 45163..45741 Streptococcus pneumoniae P1031 7680933 YP_002737306.1 CDS SPP_0071 NC_012467.1 45753 46172 D prophage pi2 protein 40 45753..46172 Streptococcus pneumoniae P1031 7682658 YP_002737307.1 CDS SPP_0072 NC_012467.1 46450 49209 D identified by match to protein family HMM PF05017; prophage LambdaSa04, tail tape measure protein, family 46450..49209 Streptococcus pneumoniae P1031 7681973 YP_002737308.1 CDS SPP_0073 NC_012467.1 49206 49928 D hypothetical protein 49206..49928 Streptococcus pneumoniae P1031 7680879 YP_002737309.1 CDS SPP_0074 NC_012467.1 49929 53150 D identified by match to protein family HMM TIGR01665; host specificity protein 49929..53150 Streptococcus pneumoniae P1031 7682122 YP_002737310.1 CDS SPP_0075 NC_012467.1 53196 55844 D PblB 53196..55844 Streptococcus pneumoniae P1031 7682093 YP_002737311.1 CDS SPP_0076 NC_012467.1 55993 56415 D identified by glimmer; putative; hypothetical protein 55993..56415 Streptococcus pneumoniae P1031 7681829 YP_002737312.1 CDS SPP_0077 NC_012467.1 56412 56528 D identified by glimmer; putative; hypothetical protein 56412..56528 Streptococcus pneumoniae P1031 7681874 YP_002737313.1 CDS SPP_0078 NC_012467.1 56509 56712 D hypothetical protein 56509..56712 Streptococcus pneumoniae P1031 7681531 YP_002737314.1 CDS SPP_0079 NC_012467.1 56715 56975 D identified by glimmer; putative; hypothetical protein 56715..56975 Streptococcus pneumoniae P1031 7681289 YP_002737315.1 CDS SPP_0080 NC_012467.1 56927 57067 D identified by glimmer; putative; hypothetical protein 56927..57067 Streptococcus pneumoniae P1031 7682772 YP_002737316.1 CDS SPP_0081 NC_012467.1 57077 57493 D identified by match to protein family HMM PF05105; match to protein family HMM TIGR01593; putative holin 1 57077..57493 Streptococcus pneumoniae P1031 7682528 YP_002737317.1 CDS SPP_0082 NC_012467.1 57497 57832 D identified by match to protein family HMM TIGR01673; phage holin, LL-H family 57497..57832 Streptococcus pneumoniae P1031 7682260 YP_002737318.1 CDS SPP_0083 NC_012467.1 57832 58788 D identified by match to protein family HMM PF01473; match to protein family HMM PF01510; lytic amidase (N-acetylmuramoyl-L-alanine amidase) 57832..58788 Streptococcus pneumoniae P1031 7680687 YP_002737319.1 CDS SPP_0084 NC_012467.1 59058 59237 R hypothetical protein complement(59058..59237) Streptococcus pneumoniae P1031 7682434 YP_002737320.1 CDS SPP_0085 NC_012467.1 59810 60277 D identified by match to protein family HMM PF00383; tRNA-specific adenosine deaminase 59810..60277 Streptococcus pneumoniae P1031 7681059 YP_002737321.1 CDS dut NC_012467.1 60464 60907 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 60464..60907 Streptococcus pneumoniae P1031 7682146 YP_002737322.1 CDS SPP_0087 NC_012467.1 60867 61424 D identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein 60867..61424 Streptococcus pneumoniae P1031 7680958 YP_002737323.1 CDS radA NC_012467.1 61537 62799 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 61537..62799 Streptococcus pneumoniae P1031 7681475 YP_002737324.1 CDS SPP_0089 NC_012467.1 62872 63369 D identified by match to protein family HMM PF00484; carbonate dehydratase 62872..63369 Streptococcus pneumoniae P1031 7680792 YP_002737325.1 CDS SPP_0090 NC_012467.1 63394 63588 D identified by glimmer; putative; hypothetical protein 63394..63588 Streptococcus pneumoniae P1031 7682360 YP_002737326.1 CDS SPP_0091 NC_012467.1 63570 64193 D hypothetical protein 63570..64193 Streptococcus pneumoniae P1031 7682348 YP_002737327.1 CDS SPP_0092 NC_012467.1 64338 65306 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 64338..65306 Streptococcus pneumoniae P1031 7682422 YP_002737328.1 CDS SPP_0093 NC_012467.1 65848 66081 R hypothetical protein complement(65848..66081) Streptococcus pneumoniae P1031 7681074 YP_002737329.1 CDS SPP_0094 NC_012467.1 66405 66719 R hypothetical protein complement(66405..66719) Streptococcus pneumoniae P1031 7681628 YP_002737330.1 CDS SPP_0095 NC_012467.1 67011 69644 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 67011..69644 Streptococcus pneumoniae P1031 7682101 YP_002737331.1 CDS SPP_0096 NC_012467.1 69729 70166 D identified by match to protein family HMM PF02629; CoA binding protein 69729..70166 Streptococcus pneumoniae P1031 7681706 YP_002737332.1 CDS SPP_0097 NC_012467.1 70207 70500 D identified by glimmer; putative; hypothetical protein 70207..70500 Streptococcus pneumoniae P1031 7681596 YP_002737333.1 CDS SPP_0098 NC_012467.1 70529 71539 R identified by match to protein family HMM PF03601; membrane protein Spr0034 complement(70529..71539) Streptococcus pneumoniae P1031 7680911 YP_002737334.1 CDS SPP_0099 NC_012467.1 71688 72857 D catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 71688..72857 Streptococcus pneumoniae P1031 7680788 YP_002737335.1 CDS recO NC_012467.1 72854 73624 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 72854..73624 Streptococcus pneumoniae P1031 7681461 YP_002737336.1 CDS plsX NC_012467.1 73621 74613 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 73621..74613 Streptococcus pneumoniae P1031 7682009 YP_002737337.1 CDS SPP_0102 NC_012467.1 74619 74852 D hypothetical protein 74619..74852 Streptococcus pneumoniae P1031 7682712 YP_002737338.1 CDS SPP_0103 NC_012467.1 74895 75188 D mobile genetic element 74895..75188 Streptococcus pneumoniae P1031 7682135 YP_002737339.1 CDS SPP_0104 NC_012467.1 75391 75621 D identified by match to protein family HMM TIGR01847; hypothetical protein 75391..75621 Streptococcus pneumoniae P1031 7682596 YP_002737340.1 CDS SPP_0105 NC_012467.1 75624 75749 D hypothetical protein 75624..75749 Streptococcus pneumoniae P1031 7682496 YP_002737341.1 CDS SPP_0106 NC_012467.1 76196 76309 R identified by glimmer; putative; hypothetical protein complement(76196..76309) Streptococcus pneumoniae P1031 7681513 YP_002737342.1 CDS SPP_0107 NC_012467.1 76336 78489 D identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193; transport/processing ATP-binding protein ComA 76336..78489 Streptococcus pneumoniae P1031 7680704 YP_002737343.1 CDS SPP_0108 NC_012467.1 78502 79851 D identified by match to protein family HMM TIGR01000; transport protein ComB 78502..79851 Streptococcus pneumoniae P1031 7681067 YP_002737344.1 CDS purC NC_012467.1 80021 80728 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 80021..80728 Streptococcus pneumoniae P1031 7682530 YP_002737345.1 CDS SPP_0110 NC_012467.1 80930 84655 D identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857; phosphoribosylformylglycinamidine synthase 80930..84655 Streptococcus pneumoniae P1031 7682280 YP_002737346.1 CDS purF NC_012467.1 84748 86190 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 84748..86190 Streptococcus pneumoniae P1031 7681955 YP_002737347.1 CDS purM NC_012467.1 86227 87249 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 86227..87249 Streptococcus pneumoniae P1031 7681212 YP_002737348.1 CDS purN NC_012467.1 87246 87791 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 87246..87791 Streptococcus pneumoniae P1031 7681729 YP_002737349.1 CDS SPP_0114 NC_012467.1 87875 88384 D identified by match to protein family HMM PF04892; teicoplanin resistance protein 87875..88384 Streptococcus pneumoniae P1031 7681372 YP_002737350.1 CDS purH NC_012467.1 88409 89956 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 88409..89956 Streptococcus pneumoniae P1031 7681646 YP_002737351.1 CDS purD NC_012467.1 90078 91340 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 90078..91340 Streptococcus pneumoniae P1031 7682651 YP_002737352.1 CDS SPP_0117 NC_012467.1 91597 91713 D hypothetical protein 91597..91713 Streptococcus pneumoniae P1031 7682803 YP_002737353.1 CDS purE NC_012467.1 91743 92231 D identified by match to protein family HMM PF00731; match to protein family HMM TIGR01162; phosphoribosylaminoimidazole carboxylase, catalytic subunit 91743..92231 Streptococcus pneumoniae P1031 7681820 YP_002737354.1 CDS purK NC_012467.1 92218 93309 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 92218..93309 Streptococcus pneumoniae P1031 7681343 YP_002737355.1 CDS SPP_0120 NC_012467.1 93319 93546 D hypothetical protein 93319..93546 Streptococcus pneumoniae P1031 7682383 YP_002737356.1 CDS purB NC_012467.1 93609 94907 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 93609..94907 Streptococcus pneumoniae P1031 7681861 YP_002737357.1 CDS SPP_0122 NC_012467.1 94962 98897 R identified by match to protein family HMM PF00728; match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-N-acetylhexosaminidase complement(94962..98897) Streptococcus pneumoniae P1031 7681331 YP_002737358.1 CDS SPP_0123 NC_012467.1 99213 99956 R identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator complement(99213..99956) Streptococcus pneumoniae P1031 7681398 YP_002737359.1 CDS SPP_0124 NC_012467.1 100277 102064 D identified by match to protein family HMM PF01301; match to protein family HMM PF02449; beta-galactosidase (Lactase) 100277..102064 Streptococcus pneumoniae P1031 7680686 YP_002737360.1 CDS SPP_0125 NC_012467.1 102061 102537 D identified by match to protein family HMM PF03830; phosphotransferase system sugar-specific eiib component 102061..102537 Streptococcus pneumoniae P1031 7682459 YP_002737361.1 CDS SPP_0126 NC_012467.1 102565 103470 D identified by match to protein family HMM PF03609; PTS system, IIC component 102565..103470 Streptococcus pneumoniae P1031 7682562 YP_002737362.1 CDS SPP_0127 NC_012467.1 103457 104272 D identified by match to protein family HMM PF03613; PTS system, IID component 103457..104272 Streptococcus pneumoniae P1031 7681528 YP_002737363.1 CDS SPP_0128 NC_012467.1 104279 104683 D identified by match to protein family HMM PF03610; phosphotransferase system sugar-specific EII component 104279..104683 Streptococcus pneumoniae P1031 7682440 YP_002737364.1 CDS SPP_0129 NC_012467.1 104982 106148 D identified by match to protein family HMM PF01380; putative tagatose-6-phosphate ketose/aldose isomerase 104982..106148 Streptococcus pneumoniae P1031 7682593 YP_002737365.1 CDS SPP_0130 NC_012467.1 106264 107301 D identified by match to protein family HMM PF01263; aldose 1-epimerase 106264..107301 Streptococcus pneumoniae P1031 7681722 YP_002737366.1 CDS SPP_0131 NC_012467.1 107508 108362 D identified by match to protein family HMM PF00903; glyoxalase family protein 107508..108362 Streptococcus pneumoniae P1031 7681210 YP_002737367.1 CDS SPP_0132 NC_012467.1 108594 108752 D identified by glimmer; putative; hypothetical protein 108594..108752 Streptococcus pneumoniae P1031 7681851 YP_002737368.1 CDS SPP_0133 NC_012467.1 108794 109201 R chlorohydrolase complement(108794..109201) Streptococcus pneumoniae P1031 7682752 YP_002737369.1 CDS SPP_0134 NC_012467.1 109255 109551 R identified by match to protein family HMM PF00581; rhodanese family protein complement(109255..109551) Streptococcus pneumoniae P1031 7682337 YP_002737370.1 CDS SPP_0135 NC_012467.1 109541 109660 R coenzyme A disulfide reductase complement(109541..109660) Streptococcus pneumoniae P1031 7682310 YP_002737371.1 CDS SPP_0136 NC_012467.1 109773 110537 D identified by match to protein family HMM PF01048; phosphorylase, Pnp/Udp family 109773..110537 Streptococcus pneumoniae P1031 7681720 YP_002737372.1 CDS SPP_0137 NC_012467.1 110793 110933 D identified by glimmer; putative; hypothetical protein 110793..110933 Streptococcus pneumoniae P1031 7682013 YP_002737373.1 CDS SPP_0138 NC_012467.1 111102 112481 D identified by match to protein family HMM PF02386; Trk transporter membrane-spanning protein - K+ transport 111102..112481 Streptococcus pneumoniae P1031 7680964 YP_002737374.1 CDS SPP_0139 NC_012467.1 112495 113160 D identified by match to protein family HMM PF02254; potassium uptake protein, Trk family 112495..113160 Streptococcus pneumoniae P1031 7680937 YP_002737375.1 CDS SPP_0140 NC_012467.1 113295 113498 D identified by glimmer; putative; hypothetical protein 113295..113498 Streptococcus pneumoniae P1031 7681095 YP_002737376.1 CDS SPP_0144 NC_012467.1 114691 117720 D identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; cell wall surface anchor family protein 114691..117720 Streptococcus pneumoniae P1031 7682848 YP_002737377.1 CDS SPP_0145 NC_012467.1 117887 118585 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator SaeR 117887..118585 Streptococcus pneumoniae P1031 7681339 YP_002737378.1 CDS SPP_0146 NC_012467.1 118582 119634 D identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; histidine kinase 118582..119634 Streptococcus pneumoniae P1031 7681610 YP_002737379.1 CDS rpsD NC_012467.1 119829 120440 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 119829..120440 Streptococcus pneumoniae P1031 7681048 YP_002737380.1 CDS SPP_0148 NC_012467.1 120625 120783 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 120625..120783 Streptococcus pneumoniae P1031 7682424 YP_002737381.1 CDS SPP_0149 NC_012467.1 121252 121467 D hypothetical protein 121252..121467 Streptococcus pneumoniae P1031 7682351 YP_002737382.1 CDS SPP_0150 NC_012467.1 121421 121594 D identified by glimmer; putative; hypothetical protein 121421..121594 Streptococcus pneumoniae P1031 7681741 YP_002737383.1 CDS SPP_0151 NC_012467.1 121930 122889 D identified by match to protein family HMM PF00528; sugar ABC transporter permease 121930..122889 Streptococcus pneumoniae P1031 7681562 YP_002737384.1 CDS SPP_0152 NC_012467.1 122903 123826 D identified by match to protein family HMM PF00528; protein LplC 122903..123826 Streptococcus pneumoniae P1031 7680682 YP_002737385.1 CDS SPP_0153 NC_012467.1 123910 125385 D identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein 123910..125385 Streptococcus pneumoniae P1031 7681946 YP_002737386.1 CDS SPP_0154 NC_012467.1 125657 126643 D identified by match to protein family HMM PF00581; hypothetical protein 125657..126643 Streptococcus pneumoniae P1031 7682515 YP_002737387.1 CDS SPP_0155 NC_012467.1 126765 127625 D hypothetical protein 126765..127625 Streptococcus pneumoniae P1031 7681252 YP_002737388.1 CDS SPP_0156 NC_012467.1 127802 128866 R hypothetical protein complement(127802..128866) Streptococcus pneumoniae P1031 7681533 YP_002737389.1 CDS SPP_0157 NC_012467.1 128929 129840 R hypothetical protein complement(128929..129840) Streptococcus pneumoniae P1031 7682866 YP_002737390.1 CDS SPP_0158 NC_012467.1 129833 130426 R hypothetical protein complement(129833..130426) Streptococcus pneumoniae P1031 7680839 YP_002737391.1 CDS SPP_0159 NC_012467.1 130413 130739 R identified by match to protein family HMM PF03551; transcription regulator complement(130413..130739) Streptococcus pneumoniae P1031 7682407 YP_002737392.1 CDS SPP_0160 NC_012467.1 130878 132044 R identified by match to protein family HMM PF07690; cyanate permease complement(130878..132044) Streptococcus pneumoniae P1031 7682517 YP_002737393.1 CDS SPP_0161 NC_012467.1 132195 133241 D identified by match to protein family HMM PF00535; glycosyl transferase 132195..133241 Streptococcus pneumoniae P1031 7682875 YP_002737394.1 CDS SPP_0162 NC_012467.1 133309 135159 D identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; CapD protein, required for the biosynthesis of type 1 capsular polysaccharide 133309..135159 Streptococcus pneumoniae P1031 7682734 YP_002737395.1 CDS SPP_0164 NC_012467.1 135462 136094 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; phosphoglycolate phosphatase complement(135462..136094) Streptococcus pneumoniae P1031 7682314 YP_002737396.1 CDS sdaAA NC_012467.1 136116 136988 R identified by match to protein family HMM PF03313; match to protein family HMM TIGR00718; L-serine dehydratase, iron-sulfur-dependent, alpha subunit complement(136116..136988) Streptococcus pneumoniae P1031 7681003 YP_002737397.1 CDS sdaAB NC_012467.1 136997 137668 R identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719; L-serine dehydratase, iron-sulfur-dependent, beta subunit complement(136997..137668) Streptococcus pneumoniae P1031 7682641 YP_002737398.1 CDS SPP_0167 NC_012467.1 137910 138482 D identified by match to protein family HMM PF01476; LysM domain protein 137910..138482 Streptococcus pneumoniae P1031 7680675 YP_002737399.1 CDS SPP_0168 NC_012467.1 139279 139563 D identified by match to protein family HMM TIGR01653; bacteriocin, lactococcin 972 family 139279..139563 Streptococcus pneumoniae P1031 7681159 YP_002737400.1 CDS SPP_0169 NC_012467.1 139618 141726 D identified by match to protein family HMM TIGR01654; amino acid ABC transporter permease 139618..141726 Streptococcus pneumoniae P1031 7682535 YP_002737401.1 CDS SPP_0170 NC_012467.1 141723 142364 D identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease protein MacB 141723..142364 Streptococcus pneumoniae P1031 7682722 YP_002737402.1 CDS SPP_0171 NC_012467.1 142571 143377 D identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein 142571..143377 Streptococcus pneumoniae P1031 7682020 YP_002737403.1 CDS argG NC_012467.1 143394 143813 D identified by match to protein family HMM PF00764; argininosuccinate synthase 143394..143813 Streptococcus pneumoniae P1031 7680814 YP_002737404.1 CDS SPP_0173 NC_012467.1 144103 144423 R hypothetical protein complement(144103..144423) Streptococcus pneumoniae P1031 7682254 YP_002737405.1 CDS SPP_0174 NC_012467.1 145187 145567 D hypothetical protein 145187..145567 Streptococcus pneumoniae P1031 7680693 YP_002737406.1 CDS SPP_0175 NC_012467.1 145941 146999 D hypothetical protein 145941..146999 Streptococcus pneumoniae P1031 7681105 YP_002737407.1 CDS SPP_0176 NC_012467.1 147314 148129 D identified by glimmer; putative; hypothetical protein 147314..148129 Streptococcus pneumoniae P1031 7682485 YP_002737408.1 CDS SPP_0177 NC_012467.1 148123 148290 D identified by glimmer; putative; hypothetical protein 148123..148290 Streptococcus pneumoniae P1031 7680859 YP_002737409.1 CDS SPP_0178 NC_012467.1 148667 149041 D hypothetical protein 148667..149041 Streptococcus pneumoniae P1031 7682349 YP_002737410.1 CDS SPP_0179 NC_012467.1 149048 149230 D hypothetical protein 149048..149230 Streptococcus pneumoniae P1031 7681446 YP_002737411.1 CDS SPP_0180 NC_012467.1 149249 150151 D hypothetical protein 149249..150151 Streptococcus pneumoniae P1031 7681509 YP_002737412.1 CDS SPP_0181 NC_012467.1 150207 150560 D hypothetical protein 150207..150560 Streptococcus pneumoniae P1031 7681178 YP_002737413.1 CDS SPP_0182 NC_012467.1 150527 151285 D hypothetical protein 150527..151285 Streptococcus pneumoniae P1031 7682508 YP_002737414.1 CDS SPP_0183 NC_012467.1 152513 152656 D hypothetical protein 152513..152656 Streptococcus pneumoniae P1031 7682246 YP_002737415.1 CDS SPP_0184 NC_012467.1 152753 152920 D identified by glimmer; putative; hypothetical protein 152753..152920 Streptococcus pneumoniae P1031 7682572 YP_002737416.1 CDS SPP_0185 NC_012467.1 153206 155041 D identified by match to protein family HMM PF01473; surface protein PspA 153206..155041 Streptococcus pneumoniae P1031 7680830 YP_002737417.1 CDS mnmA NC_012467.1 155442 156563 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 155442..156563 Streptococcus pneumoniae P1031 7681779 YP_002737418.1 CDS SPP_0187 NC_012467.1 156704 157159 D identified by match to protein family HMM PF00293; MutT/nudix family protein 156704..157159 Streptococcus pneumoniae P1031 7680786 YP_002737419.1 CDS gidA NC_012467.1 157169 159082 D GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 157169..159082 Streptococcus pneumoniae P1031 7682510 YP_002737420.1 CDS SPP_0189 NC_012467.1 159286 159444 D identified by glimmer; putative; hypothetical protein 159286..159444 Streptococcus pneumoniae P1031 7682710 YP_002737421.1 CDS SPP_0190 NC_012467.1 159461 161140 R identified by match to protein family HMM PF00753; match to protein family HMM PF07521; match to protein family HMM TIGR00649; metallo-beta-lactamase superfamily protein domain protein complement(159461..161140) Streptococcus pneumoniae P1031 7682366 YP_002737422.1 CDS SPP_0191 NC_012467.1 161142 161375 R identified by match to protein family HMM PF07288; hypothetical protein complement(161142..161375) Streptococcus pneumoniae P1031 7682478 YP_002737423.1 CDS SPP_0192 NC_012467.1 161759 161968 D identified by glimmer; putative; hypothetical protein 161759..161968 Streptococcus pneumoniae P1031 7681040 YP_002737424.1 CDS SPP_0193 NC_012467.1 162181 162333 R identified by match to protein family HMM TIGR01847; bacteriocin-type signal sequence domain protein complement(162181..162333) Streptococcus pneumoniae P1031 7680925 YP_002737425.1 CDS SPP_0194 NC_012467.1 162335 162520 R hypothetical protein complement(162335..162520) Streptococcus pneumoniae P1031 7681602 YP_002737426.1 CDS SPP_0195 NC_012467.1 162698 163381 D identified by match to protein family HMM PF00814; glycoprotein endopeptidase 162698..163381 Streptococcus pneumoniae P1031 7681843 YP_002737427.1 CDS rimI NC_012467.1 163378 163815 D identified by match to protein family HMM PF00583; match to protein family HMM TIGR01575; ribosomal-protein-alanine acetyltransferase 163378..163815 Streptococcus pneumoniae P1031 7682145 YP_002737428.1 CDS SPP_0197 NC_012467.1 163805 164815 D in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 163805..164815 Streptococcus pneumoniae P1031 7680838 YP_002737429.1 CDS SPP_0200 NC_012467.1 166869 167072 R degenerative transposase complement(166869..167072) Streptococcus pneumoniae P1031 7682735 YP_002737430.1 CDS SPP_0205 NC_012467.1 169592 171208 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 169592..171208 Streptococcus pneumoniae P1031 7682132 YP_002737431.1 CDS SPP_0206 NC_012467.1 172139 172426 D hypothetical protein 172139..172426 Streptococcus pneumoniae P1031 7682416 YP_002737432.1 CDS SPP_0207 NC_012467.1 172404 172949 D identified by glimmer; putative; hypothetical protein 172404..172949 Streptococcus pneumoniae P1031 7682046 YP_002737433.1 CDS SPP_0208 NC_012467.1 172987 173640 D hypothetical protein 172987..173640 Streptococcus pneumoniae P1031 7681188 YP_002737434.1 CDS SPP_0209 NC_012467.1 173652 174401 D identified by match to protein family HMM PF02585; GlcNAc-PI de-N-acetylase family 173652..174401 Streptococcus pneumoniae P1031 7682532 YP_002737435.1 CDS SPP_0210 NC_012467.1 174414 175586 D identified by match to protein family HMM PF00984; match to protein family HMM PF03721; match to protein family HMM TIGR03026; UDP-glucose 6-dehydrogenase 174414..175586 Streptococcus pneumoniae P1031 7682827 YP_002737436.1 CDS SPP_0211 NC_012467.1 175981 176844 D identified by match to protein family HMM TIGR01716; MutR 175981..176844 Streptococcus pneumoniae P1031 7680664 YP_002737437.1 CDS SPP_0212 NC_012467.1 177130 177363 D hypothetical protein 177130..177363 Streptococcus pneumoniae P1031 7681795 YP_002737438.1 CDS SPP_0213 NC_012467.1 177385 178062 D identified by match to protein family HMM PF02517; caax amino protease family 177385..178062 Streptococcus pneumoniae P1031 7681927 YP_002737439.1 CDS SPP_0214 NC_012467.1 178074 178739 D identified by match to protein family HMM PF02517; caax amino protease family 178074..178739 Streptococcus pneumoniae P1031 7681449 YP_002737440.1 CDS SPP_0215 NC_012467.1 178811 180037 D transporter, major facilitator family protein 178811..180037 Streptococcus pneumoniae P1031 7681189 YP_002737441.1 CDS SPP_0216 NC_012467.1 180491 181105 D identified by match to protein family HMM PF03591; AzlC family protein 180491..181105 Streptococcus pneumoniae P1031 7682542 YP_002737442.1 CDS SPP_0217 NC_012467.1 181209 182039 D identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein 181209..182039 Streptococcus pneumoniae P1031 7680866 YP_002737443.1 CDS SPP_0218 NC_012467.1 182193 183047 D identified by match to protein family HMM PF03180; lipoprotein 182193..183047 Streptococcus pneumoniae P1031 7682742 YP_002737444.1 CDS SPP_0219 NC_012467.1 183147 184520 D identified by match to protein family HMM PF01546; match to protein family HMM PF07687; acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase 183147..184520 Streptococcus pneumoniae P1031 7681768 YP_002737445.1 CDS SPP_0220 NC_012467.1 184513 185574 D identified by match to protein family HMM PF00005; methionine import ATP-binding protein MetN 184513..185574 Streptococcus pneumoniae P1031 7681175 YP_002737446.1 CDS SPP_0221 NC_012467.1 185576 186268 D identified by match to protein family HMM PF00528; ABC transporter permease 185576..186268 Streptococcus pneumoniae P1031 7681852 YP_002737447.1 CDS SPP_0222 NC_012467.1 186298 186867 R identified by match to protein family HMM TIGR02185; membrane-bound protein complement(186298..186867) Streptococcus pneumoniae P1031 7682241 YP_002737448.1 CDS SPP_0223 NC_012467.1 187002 187616 D identified by match to protein family HMM PF04854; hypothetical protein 187002..187616 Streptococcus pneumoniae P1031 7682239 YP_002737449.1 CDS SPP_0224 NC_012467.1 187666 189264 D identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF06580; sensor histidine kinase, putative 187666..189264 Streptococcus pneumoniae P1031 7682438 YP_002737450.1 CDS SPP_0225 NC_012467.1 189276 190562 D identified by match to protein family HMM PF00072; match to protein family HMM PF00165; response regulator 189276..190562 Streptococcus pneumoniae P1031 7681920 YP_002737451.1 CDS SPP_0226 NC_012467.1 190614 191147 D hypothetical protein 190614..191147 Streptococcus pneumoniae P1031 7682442 YP_002737452.1 CDS SPP_0227 NC_012467.1 191225 191695 D has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; flavoprotein NrdI 191225..191695 Streptococcus pneumoniae P1031 7680994 YP_002737453.1 CDS SPP_0228 NC_012467.1 191988 193250 R mn2+ and fe2+ transporter of the nramp family complement(191988..193250) Streptococcus pneumoniae P1031 7680918 YP_002737454.1 CDS SPP_0229 NC_012467.1 193560 194018 R hypothetical protein complement(193560..194018) Streptococcus pneumoniae P1031 7681496 YP_002737455.1 CDS SPP_0230 NC_012467.1 194015 194455 R identified by match to protein family HMM PF04397; response regulator of the LytR/AlgR family complement(194015..194455) Streptococcus pneumoniae P1031 7682361 YP_002737456.1 CDS mutL NC_012467.1 194661 196610 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 194661..196610 Streptococcus pneumoniae P1031 7681353 YP_002737457.1 CDS ribH NC_012467.1 196935 197402 R RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase complement(196935..197402) Streptococcus pneumoniae P1031 7681064 YP_002737458.1 CDS SPP_0233 NC_012467.1 197403 198608 R identified by match to protein family HMM PF00925; match to protein family HMM PF00926; match to protein family HMM TIGR00505; match to protein family HMM TIGR00506; riboflavin biosynthesis protein ribAB complement(197403..198608) Streptococcus pneumoniae P1031 7682783 YP_002737459.1 CDS ribE NC_012467.1 198628 199263 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(198628..199263) Streptococcus pneumoniae P1031 7681824 YP_002737460.1 CDS ribD NC_012467.1 199248 200348 R identified by match to protein family HMM PF00383; match to protein family HMM PF01872; match to protein family HMM TIGR00227; match to protein family HMM TIGR00326; riboflavin biosynthesis protein RibD complement(199248..200348) Streptococcus pneumoniae P1031 7682794 YP_002737461.1 CDS ruvA NC_012467.1 200753 201346 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 200753..201346 Streptococcus pneumoniae P1031 7681712 YP_002737462.1 CDS SPP_0237 NC_012467.1 201356 201919 D identified by match to protein family HMM PF03352; DNA-3-methyladenine glycosylase 1 201356..201919 Streptococcus pneumoniae P1031 7682128 YP_002737463.1 CDS SPP_0238 NC_012467.1 201916 202593 D identified by match to protein family HMM PF02517; caax amino protease family 201916..202593 Streptococcus pneumoniae P1031 7681919 YP_002737464.1 CDS SPP_0239 NC_012467.1 202730 203761 R identified by match to protein family HMM PF02016; MccC family protein complement(202730..203761) Streptococcus pneumoniae P1031 7682295 YP_002737465.1 CDS SPP_0240 NC_012467.1 204016 204699 R identified by match to protein family HMM PF06570; hypothetical protein complement(204016..204699) Streptococcus pneumoniae P1031 7681045 YP_002737466.1 CDS SPP_0241 NC_012467.1 204711 205655 R identified by match to protein family HMM PF01544; magnesium and cobalt transporter complement(204711..205655) Streptococcus pneumoniae P1031 7681810 YP_002737467.1 CDS uvrA NC_012467.1 205787 208618 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 205787..208618 Streptococcus pneumoniae P1031 7681047 YP_002737468.1 CDS SPP_0243 NC_012467.1 208611 209672 D identified by match to protein family HMM PF00557; match to protein family HMM PF01321; Xaa-Pro dipeptidase 208611..209672 Streptococcus pneumoniae P1031 7680917 YP_002737469.1 CDS spxA NC_012467.1 209804 210202 D the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 209804..210202 Streptococcus pneumoniae P1031 7681639 YP_002737470.1 CDS SPP_0245 NC_012467.1 210268 210837 D lipoprotein, putative 210268..210837 Streptococcus pneumoniae P1031 7681864 YP_002737471.1 CDS SPP_0246 NC_012467.1 210924 211190 D identified by match to protein family HMM PF06135; hypothetical protein 210924..211190 Streptococcus pneumoniae P1031 7682136 YP_002737472.1 CDS SPP_0247 NC_012467.1 211194 211613 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 211194..211613 Streptococcus pneumoniae P1031 7682555 YP_002737473.1 CDS SPP_0248 NC_012467.1 211629 211934 D identified by match to protein family HMM PF06949; hypothetical protein 211629..211934 Streptococcus pneumoniae P1031 7682270 YP_002737474.1 CDS SPP_0249 NC_012467.1 212240 213490 D identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; dihydrofolate:folylpolyglutamate synthetase 212240..213490 Streptococcus pneumoniae P1031 7682705 YP_002737475.1 CDS SPP_0250 NC_012467.1 213487 214029 D hypothetical protein 213487..214029 Streptococcus pneumoniae P1031 7681964 YP_002737476.1 CDS SPP_0251 NC_012467.1 214175 215707 D identified by match to protein family HMM PF00614; cardiolipin synthase 214175..215707 Streptococcus pneumoniae P1031 7682000 YP_002737477.1 CDS SPP_0252 NC_012467.1 215785 215928 D hypothetical protein 215785..215928 Streptococcus pneumoniae P1031 7681568 YP_002737478.1 CDS SPP_0253 NC_012467.1 215965 217503 D competence-induced protein Ccs4 215965..217503 Streptococcus pneumoniae P1031 7681388 YP_002737479.1 CDS nrdD NC_012467.1 217617 219830 D Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 217617..219830 Streptococcus pneumoniae P1031 7681894 YP_002737480.1 CDS SPP_0255 NC_012467.1 219842 219982 D hypothetical protein 219842..219982 Streptococcus pneumoniae P1031 7681525 YP_002737481.1 CDS SPP_0256 NC_012467.1 220026 220532 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 220026..220532 Streptococcus pneumoniae P1031 7681265 YP_002737482.1 CDS nrdG NC_012467.1 220525 221115 D identified by match to protein family HMM TIGR02491; anaerobic ribonucleoside-triphosphate reductase activating protein 220525..221115 Streptococcus pneumoniae P1031 7681808 YP_002737483.1 CDS SPP_0258 NC_012467.1 221112 221729 D identified by match to protein family HMM PF00485; phosphoribulokinase / Uridine kinase family 221112..221729 Streptococcus pneumoniae P1031 7681776 YP_002737484.1 CDS rpsJ NC_012467.1 221984 222292 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 221984..222292 Streptococcus pneumoniae P1031 7681326 YP_002737485.1 CDS rplC NC_012467.1 222509 223135 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 222509..223135 Streptococcus pneumoniae P1031 7681177 YP_002737486.1 CDS rplD NC_012467.1 223160 223783 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 223160..223783 Streptococcus pneumoniae P1031 7682748 YP_002737487.1 CDS rplW NC_012467.1 223783 224079 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 223783..224079 Streptococcus pneumoniae P1031 7682527 YP_002737488.1 CDS rplB NC_012467.1 224097 224930 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 224097..224930 Streptococcus pneumoniae P1031 7681156 YP_002737489.1 CDS rpsS NC_012467.1 225034 225315 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 225034..225315 Streptococcus pneumoniae P1031 7680699 YP_002737490.1 CDS rplV NC_012467.1 225327 225671 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 225327..225671 Streptococcus pneumoniae P1031 7682341 YP_002737491.1 CDS rpsC NC_012467.1 225684 226337 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 225684..226337 Streptococcus pneumoniae P1031 7680998 YP_002737492.1 CDS rplP NC_012467.1 226341 226754 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 226341..226754 Streptococcus pneumoniae P1031 7680783 YP_002737493.1 CDS rpmC NC_012467.1 226764 226970 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 226764..226970 Streptococcus pneumoniae P1031 7681657 YP_002737494.1 CDS rpsQ NC_012467.1 226995 227255 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 226995..227255 Streptococcus pneumoniae P1031 7681617 YP_002737495.1 CDS rplN NC_012467.1 227281 227649 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 227281..227649 Streptococcus pneumoniae P1031 7681648 YP_002737496.1 CDS rplX NC_012467.1 227727 228032 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 227727..228032 Streptococcus pneumoniae P1031 7681845 YP_002737497.1 CDS rplE NC_012467.1 228056 228598 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 228056..228598 Streptococcus pneumoniae P1031 7682498 YP_002737498.1 CDS rpsN NC_012467.1 228616 228885 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 228616..228885 Streptococcus pneumoniae P1031 7682382 YP_002737499.1 CDS rpsH NC_012467.1 229170 229568 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 229170..229568 Streptococcus pneumoniae P1031 7680818 YP_002737500.1 CDS rplF NC_012467.1 229760 230296 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 229760..230296 Streptococcus pneumoniae P1031 7680862 YP_002737501.1 CDS rplR NC_012467.1 230380 230736 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 230380..230736 Streptococcus pneumoniae P1031 7680956 YP_002737502.1 CDS rpsE NC_012467.1 230754 231248 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 230754..231248 Streptococcus pneumoniae P1031 7680999 YP_002737503.1 CDS rpmD NC_012467.1 231262 231444 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 231262..231444 Streptococcus pneumoniae P1031 7681076 YP_002737504.1 CDS rplO NC_012467.1 231589 232029 D late assembly protein; 50S ribosomal protein L15 231589..232029 Streptococcus pneumoniae P1031 7681885 YP_002737505.1 CDS secY NC_012467.1 232042 233352 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 232042..233352 Streptococcus pneumoniae P1031 7682853 YP_002737506.1 CDS adk NC_012467.1 233503 234141 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 233503..234141 Streptococcus pneumoniae P1031 7681184 YP_002737507.1 CDS infA NC_012467.1 234258 234476 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 234258..234476 Streptococcus pneumoniae P1031 7682595 YP_002737508.1 CDS rpmJ NC_012467.1 234501 234617 D smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 234501..234617 Streptococcus pneumoniae P1031 7682871 YP_002737509.1 CDS rpsM NC_012467.1 234635 235000 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 234635..235000 Streptococcus pneumoniae P1031 7680946 YP_002737510.1 CDS rpsK NC_012467.1 235018 235401 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 235018..235401 Streptococcus pneumoniae P1031 7681755 YP_002737511.1 CDS rpoA NC_012467.1 235444 236379 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 235444..236379 Streptococcus pneumoniae P1031 7681428 YP_002737512.1 CDS rplQ NC_012467.1 236391 236777 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 236391..236777 Streptococcus pneumoniae P1031 7682855 YP_002737513.1 CDS SPP_0288 NC_012467.1 237042 237308 D ACT domain-containing protein; hypothetical protein 237042..237308 Streptococcus pneumoniae P1031 7682386 YP_002737514.1 CDS SPP_0289 NC_012467.1 237318 238655 D identified by match to protein family HMM PF05167; hypothetical protein 237318..238655 Streptococcus pneumoniae P1031 7681464 YP_002737515.1 CDS SPP_0290 NC_012467.1 238899 239591 D identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein 238899..239591 Streptococcus pneumoniae P1031 7680871 YP_002737516.1 CDS SPP_0297 NC_012467.1 244127 244903 R identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494; pyruvate formate-lyase 3 complement(244127..244903) Streptococcus pneumoniae P1031 7681247 YP_002737517.1 CDS SPP_0298 NC_012467.1 245025 245771 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; putative HTH-type transcriptional regulator YciT 245025..245771 Streptococcus pneumoniae P1031 7682342 YP_002737518.1 CDS SPP_0299 NC_012467.1 245784 246764 D identified by match to protein family HMM PF04198; transcriptional regulator 245784..246764 Streptococcus pneumoniae P1031 7682679 YP_002737519.1 CDS SPP_0300 NC_012467.1 246959 247279 D identified by match to protein family HMM PF02255; phosphotransferase system sugar-specific eiia component 246959..247279 Streptococcus pneumoniae P1031 7681129 YP_002737520.1 CDS SPP_0301 NC_012467.1 247325 247633 D identified by match to protein family HMM PF02302; phosphotransferase system sugar-specific eiib component 247325..247633 Streptococcus pneumoniae P1031 7680903 YP_002737521.1 CDS SPP_0302 NC_012467.1 247650 248948 D identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) 247650..248948 Streptococcus pneumoniae P1031 7682861 YP_002737522.1 CDS SPP_0303 NC_012467.1 249099 251537 D identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01774; pyruvate formate-lyase 249099..251537 Streptococcus pneumoniae P1031 7681826 YP_002737523.1 CDS SPP_0304 NC_012467.1 251556 252224 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 251556..252224 Streptococcus pneumoniae P1031 7681780 YP_002737524.1 CDS gldA NC_012467.1 252242 253330 D forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 252242..253330 Streptococcus pneumoniae P1031 7681684 YP_002737525.1 CDS leuS NC_012467.1 253785 256286 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 253785..256286 Streptococcus pneumoniae P1031 7682047 YP_002737526.1 CDS SPP_0307 NC_012467.1 256480 257175 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 256480..257175 Streptococcus pneumoniae P1031 7681123 YP_002737527.1 CDS SPP_0308 NC_012467.1 257187 257603 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 257187..257603 Streptococcus pneumoniae P1031 7681577 YP_002737528.1 CDS ruvB NC_012467.1 258644 259642 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 258644..259642 Streptococcus pneumoniae P1031 7681381 YP_002737529.1 CDS SPP_0310 NC_012467.1 259623 260195 D identified by match to protein family HMM PF06042; hypothetical protein 259623..260195 Streptococcus pneumoniae P1031 7681555 YP_002737530.1 CDS uppS NC_012467.1 260426 261184 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase 260426..261184 Streptococcus pneumoniae P1031 7682476 YP_002737531.1 CDS cdsA NC_012467.1 261193 261996 D identified by match to protein family HMM PF01148; phosphatidate cytidylyltransferase 261193..261996 Streptococcus pneumoniae P1031 7681799 YP_002737532.1 CDS rseP NC_012467.1 262018 263277 D identified by match to protein family HMM PF02163; match to protein family HMM TIGR00054; RIP metalloprotease RseP 262018..263277 Streptococcus pneumoniae P1031 7681276 YP_002737533.1 CDS proS NC_012467.1 263290 265143 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 263290..265143 Streptococcus pneumoniae P1031 7681242 YP_002737534.1 CDS SPP_0315 NC_012467.1 265242 266621 D identified by match to protein family HMM PF00232; 6-phospho-beta-glucosidase 265242..266621 Streptococcus pneumoniae P1031 7681886 YP_002737535.1 CDS glmS NC_012467.1 266814 268622 D Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 266814..268622 Streptococcus pneumoniae P1031 7682191 YP_002737536.1 CDS SPP_0317 NC_012467.1 268634 268837 R chlorohydrolase complement(268634..268837) Streptococcus pneumoniae P1031 7681268 YP_002737537.1 CDS SPP_0318 NC_012467.1 268894 269943 D identified by match to protein family HMM PF00296; oxidoreductase 268894..269943 Streptococcus pneumoniae P1031 7681735 YP_002737538.1 CDS SPP_0319 NC_012467.1 270043 273813 R identified by match to protein family HMM PF00128; match to protein family HMM PF00746; match to protein family HMM PF02922; match to protein family HMM PF03714; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; match to protein family HMM TIGR02102; pullulanase, extracellular complement(270043..273813) Streptococcus pneumoniae P1031 7681230 YP_002737539.1 CDS rpsL NC_012467.1 274230 274643 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 274230..274643 Streptococcus pneumoniae P1031 7682402 YP_002737540.1 CDS rpsG NC_012467.1 274663 275133 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 274663..275133 Streptococcus pneumoniae P1031 7682739 YP_002737541.1 CDS fusA NC_012467.1 275558 277639 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 275558..277639 Streptococcus pneumoniae P1031 7681569 YP_002737542.1 CDS polC NC_012467.1 277743 282134 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 277743..282134 Streptococcus pneumoniae P1031 7681654 YP_002737543.1 CDS SPP_0324 NC_012467.1 282236 282499 D identified by match to protein family HMM PF04221; match to protein family HMM TIGR02384; addiction module antitoxin, RelB/DinJ family 282236..282499 Streptococcus pneumoniae P1031 7681719 YP_002737544.1 CDS SPP_0325 NC_012467.1 282492 282770 D identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; DNA damage inducible protein 282492..282770 Streptococcus pneumoniae P1031 7681243 YP_002737545.1 CDS SPP_0326 NC_012467.1 282791 282943 D hypothetical protein 282791..282943 Streptococcus pneumoniae P1031 7681235 YP_002737546.1 CDS SPP_0327 NC_012467.1 282965 284206 D identified by match to protein family HMM PF02073; aminopeptidase PepS 282965..284206 Streptococcus pneumoniae P1031 7681092 YP_002737547.1 CDS SPP_0328 NC_012467.1 284216 284446 D identified by match to protein family HMM PF04226; integral membrane protein 284216..284446 Streptococcus pneumoniae P1031 7680842 YP_002737548.1 CDS SPP_0329 NC_012467.1 284669 285391 D identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A, putative 284669..285391 Streptococcus pneumoniae P1031 7682638 YP_002737549.1 CDS SPP_0330 NC_012467.1 285608 286942 D identified by match to protein family HMM PF03051; aminopeptidase C (Bleomycin hydrolase) 285608..286942 Streptococcus pneumoniae P1031 7682717 YP_002737550.1 CDS SPP_0331 NC_012467.1 286998 287909 R identified by match to protein family HMM PF03613; match to protein family HMM TIGR00828; PTS system, mannose/fructose/sorbose family, IID component complement(286998..287909) Streptococcus pneumoniae P1031 7681367 YP_002737551.1 CDS SPP_0332 NC_012467.1 287933 288736 R identified by match to protein family HMM PF03609; PTS system sorbose-specific IIC component complement(287933..288736) Streptococcus pneumoniae P1031 7681073 YP_002737552.1 CDS SPP_0333 NC_012467.1 288764 289753 R identified by match to protein family HMM PF03610; match to protein family HMM PF03830; mannose-specific phosphotransferase system component iiab complement(288764..289753) Streptococcus pneumoniae P1031 7681576 YP_002737553.1 CDS SPP_0334 NC_012467.1 289986 291005 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(289986..291005) Streptococcus pneumoniae P1031 7682235 YP_002737554.1 CDS SPP_0335 NC_012467.1 291114 291260 R identified by glimmer; putative; hypothetical protein complement(291114..291260) Streptococcus pneumoniae P1031 7682106 YP_002737555.1 CDS SPP_0336 NC_012467.1 291344 292156 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(291344..292156) Streptococcus pneumoniae P1031 7681660 YP_002737556.1 CDS SPP_0337 NC_012467.1 292346 293764 D identified by match to protein family HMM PF00860; xanthine/uracil permease family protein 292346..293764 Streptococcus pneumoniae P1031 7682283 YP_002737557.1 CDS SPP_0338 NC_012467.1 293817 294524 D identified by match to protein family HMM PF02517; caax amino protease family protein 293817..294524 Streptococcus pneumoniae P1031 7682779 YP_002737558.1 CDS folP NC_012467.1 294620 295600 D identified by match to protein family HMM PF00809; match to protein family HMM TIGR01496; dihydropteroate synthase 294620..295600 Streptococcus pneumoniae P1031 7682158 YP_002737559.1 CDS SPP_0340 NC_012467.1 295602 296924 D identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; dihydrofolate synthetase 295602..296924 Streptococcus pneumoniae P1031 7681126 YP_002737560.1 CDS folE NC_012467.1 296905 297459 D involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 296905..297459 Streptococcus pneumoniae P1031 7681481 YP_002737561.1 CDS SPP_0342 NC_012467.1 297502 298314 D identified by match to protein family HMM PF01288; match to protein family HMM PF02152; match to protein family HMM TIGR00525; match to protein family HMM TIGR00526; match to protein family HMM TIGR01498; bifunctional folate synthesis protein 297502..298314 Streptococcus pneumoniae P1031 7682842 YP_002737562.1 CDS SPP_0343 NC_012467.1 298359 298676 R hypothetical protein complement(298359..298676) Streptococcus pneumoniae P1031 7682203 YP_002737563.1 CDS rplM NC_012467.1 299033 299479 D in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 299033..299479 Streptococcus pneumoniae P1031 7682447 YP_002737564.1 CDS rpsI NC_012467.1 299498 299890 D forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 299498..299890 Streptococcus pneumoniae P1031 7681933 YP_002737565.1 CDS SPP_0346 NC_012467.1 300152 300574 R identified by match to protein family HMM PF00589; integrase/recombinase, phage integrase family complement(300152..300574) Streptococcus pneumoniae P1031 7682005 YP_002737566.1 CDS SPP_0347 NC_012467.1 300721 300897 D hypothetical protein 300721..300897 Streptococcus pneumoniae P1031 7681604 YP_002737567.1 CDS SPP_0348 NC_012467.1 301299 303512 D identified by match to protein family HMM PF01055; glycosyl hydrolase, family 31 301299..303512 Streptococcus pneumoniae P1031 7682702 YP_002737568.1 CDS SPP_0349 NC_012467.1 303734 304210 R identified by match to protein family HMM PF00255; peroxiredoxin Hyr1 (hydrogen peroxide resistanceprotein 1) (oxidant receptor peroxidase 1) (glutathione peroxidase 3)(phospholipid hydroperoxide glutathione peroxidase 3) (phgpx3) complement(303734..304210) Streptococcus pneumoniae P1031 7682141 YP_002737569.1 CDS SPP_0350 NC_012467.1 304433 307636 D identified by match to protein family HMM PF00746; match to protein family HMM PF02018; match to protein family HMM PF02278; match to protein family HMM PF02884; match to protein family HMM PF08124; match to protein family HMM TIGR01167; hyaluronate lyase 304433..307636 Streptococcus pneumoniae P1031 7681333 YP_002737570.1 CDS SPP_0352 NC_012467.1 308779 309408 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(308779..309408) Streptococcus pneumoniae P1031 7681029 YP_002737571.1 CDS SPP_0353 NC_012467.1 309418 310419 R carbohydrate kinase, PfkB family complement(309418..310419) Streptococcus pneumoniae P1031 7680868 YP_002737572.1 CDS SPP_0354 NC_012467.1 310450 311091 R identified by match to protein family HMM PF02502; hypothetical protein complement(310450..311091) Streptococcus pneumoniae P1031 7681606 YP_002737573.1 CDS SPP_0355 NC_012467.1 311110 311925 R Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase complement(311110..311925) Streptococcus pneumoniae P1031 7682691 YP_002737574.1 CDS SPP_0356 NC_012467.1 312196 312630 D identified by match to protein family HMM PF03610; phosphotransferase system sugar-specific EII component 312196..312630 Streptococcus pneumoniae P1031 7682095 YP_002737575.1 CDS SPP_0357 NC_012467.1 312642 313832 D identified by match to protein family HMM PF07470; unsaturated glucuronyl hydrolase (UGL) (Glycuronidase)(Unsaturated uronic acid hydrolase) (Glycosaminoglycan hydrolase) 312642..313832 Streptococcus pneumoniae P1031 7681425 YP_002737576.1 CDS SPP_0358 NC_012467.1 313843 314334 D identified by match to protein family HMM PF03830; N-acetylgalactosamine-specific phosphotransferase enzyme iib component2 (pts system n-acetylgalactosamine-specific eiibcomponent 2) (eiib-aga') 313843..314334 Streptococcus pneumoniae P1031 7681211 YP_002737577.1 CDS SPP_0359 NC_012467.1 314349 315128 D identified by match to protein family HMM PF03609; phosphotransferase system sugar-specific EII component 314349..315128 Streptococcus pneumoniae P1031 7682516 YP_002737578.1 CDS SPP_0360 NC_012467.1 315115 315933 D identified by match to protein family HMM PF03613; PTS system, IID component 315115..315933 Streptococcus pneumoniae P1031 7682255 YP_002737579.1 CDS SPP_0361 NC_012467.1 315969 316226 D preprotein translocase, YajC subunit 315969..316226 Streptococcus pneumoniae P1031 7680680 YP_002737580.1 CDS SPP_0362 NC_012467.1 316248 318149 D identified by match to protein family HMM PF07940; oligohyaluronate lyase 316248..318149 Streptococcus pneumoniae P1031 7682286 YP_002737581.1 CDS SPP_0363 NC_012467.1 318209 319210 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sugar binding transcriptional regulator RegR 318209..319210 Streptococcus pneumoniae P1031 7682570 YP_002737582.1 CDS SPP_0364 NC_012467.1 319320 319655 R identified by glimmer; putative; hypothetical protein complement(319320..319655) Streptococcus pneumoniae P1031 7681499 YP_002737583.1 CDS SPP_0365 NC_012467.1 319666 319908 R identified by glimmer; putative; hypothetical protein complement(319666..319908) Streptococcus pneumoniae P1031 7681385 YP_002737584.1 CDS SPP_0366 NC_012467.1 319919 320461 R hypothetical protein complement(319919..320461) Streptococcus pneumoniae P1031 7682730 YP_002737585.1 CDS SPP_0367 NC_012467.1 320477 320671 R identified by match to protein family HMM PF01381; hypothetical protein complement(320477..320671) Streptococcus pneumoniae P1031 7681847 YP_002737586.1 CDS mraW NC_012467.1 320837 321787 D identified by match to protein family HMM PF01795; match to protein family HMM TIGR00006; S-adenosyl-methyltransferase MraW 320837..321787 Streptococcus pneumoniae P1031 7682123 YP_002737587.1 CDS ftsL NC_012467.1 321799 322116 D identified by match to protein family HMM TIGR02209; cell division protein FtsL 321799..322116 Streptococcus pneumoniae P1031 7681970 YP_002737588.1 CDS SPP_0370 NC_012467.1 322120 324372 D identified by match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM PF03793; penicillin-binding protein 2X 322120..324372 Streptococcus pneumoniae P1031 7681634 YP_002737589.1 CDS mraY NC_012467.1 324374 325354 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 324374..325354 Streptococcus pneumoniae P1031 7681685 YP_002737590.1 CDS SPP_0372 NC_012467.1 325566 325682 D identified by glimmer; putative; hypothetical protein 325566..325682 Streptococcus pneumoniae P1031 7681471 YP_002737591.1 CDS SPP_0373 NC_012467.1 325963 328068 D identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; ATP-dependent Clp protease ATP-binding subunit ClpL 325963..328068 Streptococcus pneumoniae P1031 7682788 YP_002737592.1 CDS SPP_0374 NC_012467.1 328506 328856 D identified by match to protein family HMM PF08388; GBSi1, group II intron, maturase 328506..328856 Streptococcus pneumoniae P1031 7680886 YP_002737593.1 CDS luxS NC_012467.1 328923 329405 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(328923..329405) Streptococcus pneumoniae P1031 7680711 YP_002737594.1 CDS SPP_0376 NC_012467.1 329500 330984 R identified by match to protein family HMM PF08903; hypothetical protein complement(329500..330984) Streptococcus pneumoniae P1031 7682628 YP_002737595.1 CDS SPP_0377 NC_012467.1 331137 332744 D identified by match to protein family HMM PF00128; trehalose-6-phosphate hydrolase (Alpha,alpha-phosphotrehalase) 331137..332744 Streptococcus pneumoniae P1031 7682751 YP_002737596.1 CDS SPP_0378 NC_012467.1 332903 333076 D lipoprotein, putative 332903..333076 Streptococcus pneumoniae P1031 7682509 YP_002737597.1 CDS SPP_0381 NC_012467.1 334773 334898 D identified by glimmer; putative; hypothetical protein 334773..334898 Streptococcus pneumoniae P1031 7681621 YP_002737598.1 CDS SPP_0382 NC_012467.1 334994 335392 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01710; Spn1, transposase Orf1 complement(334994..335392) Streptococcus pneumoniae P1031 7681774 YP_002737599.1 CDS SPP_0383 NC_012467.1 335645 337090 D identified by match to protein family HMM PF02916; match to protein family HMM PF03816; match to protein family HMM TIGR00350; integral membrane regulatory protein Wzg 335645..337090 Streptococcus pneumoniae P1031 7682144 YP_002737600.1 CDS SPP_0384 NC_012467.1 337092 337823 D identified by match to protein family HMM PF02811; tyrosine-protein phosphatase CpsB 337092..337823 Streptococcus pneumoniae P1031 7682657 YP_002737601.1 CDS SPP_0385 NC_012467.1 337832 338524 D identified by match to protein family HMM PF02706; match to protein family HMM TIGR01006; capsular polysaccharide biosynthesis protein Wzd 337832..338524 Streptococcus pneumoniae P1031 7682373 YP_002737602.1 CDS SPP_0386 NC_012467.1 338534 339199 D identified by match to protein family HMM TIGR01007; tyrosine-protein kinase CpsD 338534..339199 Streptococcus pneumoniae P1031 7680978 YP_002737603.1 CDS SPP_0387 NC_012467.1 339340 340476 D identified by match to protein family HMM PF00534; galacturonosyl transferase 339340..340476 Streptococcus pneumoniae P1031 7681335 YP_002737604.1 CDS SPP_0388 NC_012467.1 340469 341020 D galacturonic acid acetylase 340469..341020 Streptococcus pneumoniae P1031 7680809 YP_002737605.1 CDS SPP_0389 NC_012467.1 341017 342171 D identified by match to protein family HMM PF00534; glycosyl transferase, group 1 family protein 341017..342171 Streptococcus pneumoniae P1031 7682699 YP_002737606.1 CDS SPP_0390 NC_012467.1 342288 343592 D hypothetical protein 342288..343592 Streptococcus pneumoniae P1031 7680982 YP_002737607.1 CDS SPP_0391 NC_012467.1 343778 344947 D identified by match to protein family HMM PF01943; flippase Wzx 343778..344947 Streptococcus pneumoniae P1031 7682232 YP_002737608.1 CDS SPP_0392 NC_012467.1 345015 346085 D identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; UDP-glucuronate 5'-epimerase (UDP-glucuronic acidepimerase) 345015..346085 Streptococcus pneumoniae P1031 7682216 YP_002737609.1 CDS SPP_0393 NC_012467.1 346114 347346 D identified by match to protein family HMM PF00984; match to protein family HMM PF01210; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026; UDP-glucose 6-dehydrogenase 346114..347346 Streptococcus pneumoniae P1031 7681133 YP_002737610.1 CDS SPP_0394 NC_012467.1 347562 347744 D identified by glimmer; putative; hypothetical protein 347562..347744 Streptococcus pneumoniae P1031 7682376 YP_002737611.1 CDS SPP_0395 NC_012467.1 348032 348382 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; transposase complement(348032..348382) Streptococcus pneumoniae P1031 7682839 YP_002737612.1 CDS rfbA NC_012467.1 349552 350409 D identified by match to protein family HMM PF00483; match to protein family HMM TIGR01207; glucose-1-phosphate thymidylyltransferase 349552..350409 Streptococcus pneumoniae P1031 7681694 YP_002737613.1 CDS SPP_0399 NC_012467.1 350410 351006 D identified by match to protein family HMM PF00908; dTDP-4-dehydrorhamnose 3,5-epimerase 350410..351006 Streptococcus pneumoniae P1031 7681107 YP_002737614.1 CDS rfbB NC_012467.1 351016 352065 D identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181; dTDP-glucose 4,6-dehydratase 351016..352065 Streptococcus pneumoniae P1031 7681877 YP_002737615.1 CDS SPP_0403 NC_012467.1 353057 353491 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; transposase 353057..353491 Streptococcus pneumoniae P1031 7682055 YP_002737616.1 CDS SPP_0405 NC_012467.1 354409 356391 D identified by match to protein family HMM PF00496; oligopeptide binding protein 354409..356391 Streptococcus pneumoniae P1031 7682625 YP_002737617.1 CDS SPP_0406 NC_012467.1 356692 361995 D identified by match to protein family HMM PF00754; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; endo-alpha-N-acetylgalactosaminidase 356692..361995 Streptococcus pneumoniae P1031 7682629 YP_002737618.1 CDS SPP_0407 NC_012467.1 362162 364321 R identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 1A complement(362162..364321) Streptococcus pneumoniae P1031 7681731 YP_002737619.1 CDS recU NC_012467.1 364318 364914 R functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease complement(364318..364914) Streptococcus pneumoniae P1031 7682045 YP_002737620.1 CDS SPP_0409 NC_012467.1 364980 365507 D identified by match to protein family HMM PF06908; hypothetical protein 364980..365507 Streptococcus pneumoniae P1031 7680840 YP_002737621.1 CDS SPP_0410 NC_012467.1 365577 365906 D identified by match to protein family HMM PF05103; cell division initiation protein 365577..365906 Streptococcus pneumoniae P1031 7682526 YP_002737622.1 CDS SPP_0411 NC_012467.1 366392 367549 D identified by match to protein family HMM PF01170; methyltransferase 366392..367549 Streptococcus pneumoniae P1031 7680714 YP_002737623.1 CDS SPP_0412 NC_012467.1 367562 368956 D hypothetical protein 367562..368956 Streptococcus pneumoniae P1031 7682024 YP_002737624.1 CDS gnd NC_012467.1 369032 370456 D catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 369032..370456 Streptococcus pneumoniae P1031 7681838 YP_002737625.1 CDS SPP_0414 NC_012467.1 370468 371157 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator 370468..371157 Streptococcus pneumoniae P1031 7680688 YP_002737626.1 CDS SPP_0415 NC_012467.1 371255 372274 D identified by match to protein family HMM PF01473; choline-binding protein F 371255..372274 Streptococcus pneumoniae P1031 7681217 YP_002737627.1 CDS SPP_0416 NC_012467.1 372392 373624 R identified by match to protein family HMM PF07690; transporter, major facilitator family protein complement(372392..373624) Streptococcus pneumoniae P1031 7681950 YP_002737628.1 CDS SPP_0418 NC_012467.1 375305 375484 D identified by match to protein family HMM PF01473; choline binding protein J 375305..375484 Streptococcus pneumoniae P1031 7682111 YP_002737629.1 CDS mvk NC_012467.1 375606 376484 D identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR00549; mevalonate kinase 375606..376484 Streptococcus pneumoniae P1031 7681825 YP_002737630.1 CDS mvaD NC_012467.1 376466 377419 D identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR01240; diphosphomevalonate decarboxylase 376466..377419 Streptococcus pneumoniae P1031 7682419 YP_002737631.1 CDS SPP_0421 NC_012467.1 377406 378413 D identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR01220; phosphomevalonate kinase 377406..378413 Streptococcus pneumoniae P1031 7682368 YP_002737632.1 CDS fni NC_012467.1 378397 379407 D catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 378397..379407 Streptococcus pneumoniae P1031 7680928 YP_002737633.1 CDS SPP_0423 NC_012467.1 379484 380182 D hypothetical protein 379484..380182 Streptococcus pneumoniae P1031 7681038 YP_002737634.1 CDS SPP_0424 NC_012467.1 380179 381174 D identified by match to protein family HMM PF02518; match to protein family HMM PF07730; histidine kinase 380179..381174 Streptococcus pneumoniae P1031 7682615 YP_002737635.1 CDS SPP_0425 NC_012467.1 381188 381820 D identified by match to protein family HMM PF00072; match to protein family HMM PF00196; match to protein family HMM PF08281; response regulator 381188..381820 Streptococcus pneumoniae P1031 7682843 YP_002737636.1 CDS SPP_0428 NC_012467.1 382414 382590 D DNA alkylation repair enzyme, truncation 382414..382590 Streptococcus pneumoniae P1031 7682732 YP_002737637.1 CDS SPP_0429 NC_012467.1 382740 382979 D hypothetical protein 382740..382979 Streptococcus pneumoniae P1031 7682052 YP_002737638.1 CDS SPP_0430 NC_012467.1 382976 383653 D identified by match to protein family HMM PF00089; choline binding protein G 382976..383653 Streptococcus pneumoniae P1031 7680847 YP_002737639.1 CDS SPP_0431 NC_012467.1 383952 384344 D integrase 383952..384344 Streptococcus pneumoniae P1031 7680684 YP_002737640.1 CDS tig NC_012467.1 384505 385788 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 384505..385788 Streptococcus pneumoniae P1031 7682285 YP_002737641.1 CDS SPP_0433 NC_012467.1 385836 388202 R identified by match to protein family HMM TIGR01448; helicase, RecD/TraA family complement(385836..388202) Streptococcus pneumoniae P1031 7682608 YP_002737642.1 CDS lepB NC_012467.1 388330 388944 R identified by match to protein family HMM PF00717; match to protein family HMM TIGR02227; signal peptidase I complement(388330..388944) Streptococcus pneumoniae P1031 7682471 YP_002737643.1 CDS rnhC NC_012467.1 388956 389828 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII complement(388956..389828) Streptococcus pneumoniae P1031 7681225 YP_002737644.1 CDS SPP_0436 NC_012467.1 389993 390217 D hypothetical protein 389993..390217 Streptococcus pneumoniae P1031 7682186 YP_002737645.1 CDS cvpA NC_012467.1 390214 390762 D identified by match to protein family HMM PF02674; CvpA family protein 390214..390762 Streptococcus pneumoniae P1031 7680623 YP_002737646.1 CDS SPP_0438 NC_012467.1 390866 393202 D identified by match to protein family HMM PF00488; match to protein family HMM PF01713; match to protein family HMM TIGR01069; MutS2 family protein 390866..393202 Streptococcus pneumoniae P1031 7681609 YP_002737647.1 CDS SPP_0439 NC_012467.1 393545 394867 D identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835; D-alanine glycine permease 393545..394867 Streptococcus pneumoniae P1031 7682359 YP_002737648.1 CDS SPP_0440 NC_012467.1 395085 395633 D identified by match to protein family HMM PF02627; match to protein family HMM TIGR00778; macrophage infectivity potentiator protein 395085..395633 Streptococcus pneumoniae P1031 7681350 YP_002737649.1 CDS SPP_0441 NC_012467.1 395743 396642 D identified by match to protein family HMM PF03595; exfoliative toxin A 395743..396642 Streptococcus pneumoniae P1031 7682096 YP_002737650.1 CDS serS NC_012467.1 396667 397941 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(396667..397941) Streptococcus pneumoniae P1031 7682652 YP_002737651.1 CDS SPP_0443 NC_012467.1 398155 398526 R identified by match to protein family HMM PF06115; ManO complement(398155..398526) Streptococcus pneumoniae P1031 7682249 YP_002737652.1 CDS SPP_0444 NC_012467.1 398529 399893 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase complement(398529..399893) Streptococcus pneumoniae P1031 7682212 YP_002737653.1 CDS SPP_0445 NC_012467.1 400071 400226 R hypothetical protein complement(400071..400226) Streptococcus pneumoniae P1031 7681043 YP_002737654.1 CDS SPP_0446 NC_012467.1 400218 401003 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 400218..401003 Streptococcus pneumoniae P1031 7681112 YP_002737655.1 CDS SPP_0447 NC_012467.1 401097 401531 D identified by match to protein family HMM PF01047; match to protein family HMM PF03965; transcriptional regulator 401097..401531 Streptococcus pneumoniae P1031 7681083 YP_002737656.1 CDS SPP_0448 NC_012467.1 401531 402505 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 401531..402505 Streptococcus pneumoniae P1031 7681773 YP_002737657.1 CDS acpP NC_012467.1 402565 402789 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 402565..402789 Streptococcus pneumoniae P1031 7681979 YP_002737658.1 CDS SPP_0450 NC_012467.1 402908 403882 D identified by match to protein family HMM PF03060; match to protein family HMM TIGR03151; enoyl-ACP reductase II 402908..403882 Streptococcus pneumoniae P1031 7682838 YP_002737659.1 CDS fabD NC_012467.1 403875 404795 D identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128; malonyl CoA-acyl carrier protein transacylase 403875..404795 Streptococcus pneumoniae P1031 7682129 YP_002737660.1 CDS fabG NC_012467.1 404829 405560 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 404829..405560 Streptococcus pneumoniae P1031 7682540 YP_002737661.1 CDS fabF NC_012467.1 405582 406817 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 405582..406817 Streptococcus pneumoniae P1031 7681007 YP_002737662.1 CDS accB NC_012467.1 406820 407305 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 406820..407305 Streptococcus pneumoniae P1031 7682019 YP_002737663.1 CDS fabZ NC_012467.1 407302 407724 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 407302..407724 Streptococcus pneumoniae P1031 7682029 YP_002737664.1 CDS accC NC_012467.1 407736 409103 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 407736..409103 Streptococcus pneumoniae P1031 7681183 YP_002737665.1 CDS accD NC_012467.1 409140 410006 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 409140..410006 Streptococcus pneumoniae P1031 7681545 YP_002737666.1 CDS accA NC_012467.1 410003 410770 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha 410003..410770 Streptococcus pneumoniae P1031 7680863 YP_002737667.1 CDS SPP_0459 NC_012467.1 410929 411114 D hypothetical protein 410929..411114 Streptococcus pneumoniae P1031 7682267 YP_002737668.1 CDS SPP_0460 NC_012467.1 411171 411605 D hypothetical protein 411171..411605 Streptococcus pneumoniae P1031 7680683 YP_002737669.1 CDS SPP_0461 NC_012467.1 411756 411890 R identified by glimmer; putative; hypothetical protein complement(411756..411890) Streptococcus pneumoniae P1031 7680703 YP_002737670.1 CDS nusB NC_012467.1 411904 412326 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(411904..412326) Streptococcus pneumoniae P1031 7681199 YP_002737671.1 CDS SPP_0463 NC_012467.1 412319 412708 R identified by match to protein family HMM PF03780; general stress protein, Gls24 family complement(412319..412708) Streptococcus pneumoniae P1031 7682547 YP_002737672.1 CDS efp NC_012467.1 412730 413290 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(412730..413290) Streptococcus pneumoniae P1031 7681485 YP_002737673.1 CDS SPP_0465 NC_012467.1 413458 413643 D chlorohydrolase 413458..413643 Streptococcus pneumoniae P1031 7682477 YP_002737674.1 CDS SPP_0466 NC_012467.1 413668 414711 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; L-iditol 2-dehydrogenase complement(413668..414711) Streptococcus pneumoniae P1031 7681527 YP_002737675.1 CDS gatB NC_012467.1 414835 416277 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(414835..416277) Streptococcus pneumoniae P1031 7681361 YP_002737676.1 CDS gatA NC_012467.1 416277 417743 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(416277..417743) Streptococcus pneumoniae P1031 7681619 YP_002737677.1 CDS gatC NC_012467.1 417743 418045 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(417743..418045) Streptococcus pneumoniae P1031 7682430 YP_002737678.1 CDS prfC NC_012467.1 418258 419802 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 418258..419802 Streptococcus pneumoniae P1031 7681071 YP_002737679.1 CDS SPP_0471 NC_012467.1 420071 420556 D identified by match to protein family HMM PF01501; glycosyl transferase, family 8 420071..420556 Streptococcus pneumoniae P1031 7681257 YP_002737680.1 CDS rpmB NC_012467.1 420672 420860 D required for 70S ribosome assembly; 50S ribosomal protein L28 420672..420860 Streptococcus pneumoniae P1031 7682369 YP_002737681.1 CDS SPP_0473 NC_012467.1 421017 421382 D identified by match to protein family HMM PF03780; alkaline shock protein 421017..421382 Streptococcus pneumoniae P1031 7682791 YP_002737682.1 CDS SPP_0474 NC_012467.1 421385 423052 D identified by match to protein family HMM PF02734; dihydroxyacetone kinase family protein 421385..423052 Streptococcus pneumoniae P1031 7682630 YP_002737683.1 CDS ilvB NC_012467.1 423253 424953 D catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit 423253..424953 Streptococcus pneumoniae P1031 7681961 YP_002737684.1 CDS ilvH NC_012467.1 424946 425422 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 424946..425422 Streptococcus pneumoniae P1031 7681474 YP_002737685.1 CDS ilvC NC_012467.1 425488 426510 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 425488..426510 Streptococcus pneumoniae P1031 7680955 YP_002737686.1 CDS SPP_0478 NC_012467.1 426617 426853 D hypothetical protein 426617..426853 Streptococcus pneumoniae P1031 7682694 YP_002737687.1 CDS SPP_0479 NC_012467.1 427091 427447 D hypothetical protein 427091..427447 Streptococcus pneumoniae P1031 7681558 YP_002737688.1 CDS ilvA NC_012467.1 427497 428747 D catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 427497..428747 Streptococcus pneumoniae P1031 7682320 YP_002737689.1 CDS SPP_0481 NC_012467.1 428889 429077 D hypothetical protein 428889..429077 Streptococcus pneumoniae P1031 7682319 YP_002737690.1 CDS SPP_0482 NC_012467.1 429618 429833 D hypothetical protein 429618..429833 Streptococcus pneumoniae P1031 7682616 YP_002737691.1 CDS gltL NC_012467.1 429942 430682 R identified by match to protein family HMM PF00005; glutamate/aspartate ABC transporter, ATP-binding protein complement(429942..430682) Streptococcus pneumoniae P1031 7682116 YP_002737692.1 CDS SPP_0484 NC_012467.1 430682 432247 R identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease/substrate-binding protein complement(430682..432247) Streptococcus pneumoniae P1031 7682505 YP_002737693.1 CDS SPP_0486 NC_012467.1 432385 434274 D hypothetical protein 432385..434274 Streptococcus pneumoniae P1031 7681717 YP_002737694.1 CDS SPP_0485 NC_012467.1 434271 434441 R hypothetical protein complement(434271..434441) Streptococcus pneumoniae P1031 7681797 YP_002737695.1 CDS SPP_0487 NC_012467.1 434575 435123 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF02371; transposase complement(434575..435123) Streptococcus pneumoniae P1031 7681196 YP_002737696.1 CDS SPP_0488 NC_012467.1 435321 435443 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(435321..435443) Streptococcus pneumoniae P1031 7681321 YP_002737697.1 CDS SPP_0489 NC_012467.1 435699 436544 D BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 435699..436544 Streptococcus pneumoniae P1031 7682252 YP_002737698.1 CDS SPP_0490 NC_012467.1 436537 436665 D hypothetical protein 436537..436665 Streptococcus pneumoniae P1031 7682523 YP_002737699.1 CDS SPP_0491 NC_012467.1 436691 437752 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(436691..437752) Streptococcus pneumoniae P1031 7681186 YP_002737700.1 CDS SPP_0492 NC_012467.1 437797 437919 R identified by glimmer; putative; hypothetical protein complement(437797..437919) Streptococcus pneumoniae P1031 7682043 YP_002737701.1 CDS pflB NC_012467.1 438147 440471 D identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255; formate acetyltransferase 438147..440471 Streptococcus pneumoniae P1031 7681013 YP_002737702.1 CDS SPP_0494 NC_012467.1 440843 441061 R hypothetical protein complement(440843..441061) Streptococcus pneumoniae P1031 7681756 YP_002737703.1 CDS SPP_0495 NC_012467.1 441388 441672 R hypothetical protein complement(441388..441672) Streptococcus pneumoniae P1031 7681924 YP_002737704.1 CDS SPP_0496 NC_012467.1 442064 442237 D identified by glimmer; putative; hypothetical protein 442064..442237 Streptococcus pneumoniae P1031 7681399 YP_002737705.1 CDS SPP_0497 NC_012467.1 442876 442989 R identified by glimmer; putative; hypothetical protein complement(442876..442989) Streptococcus pneumoniae P1031 7680961 YP_002737706.1 CDS SPP_0498 NC_012467.1 443277 444500 R identified by match to protein family HMM PF00480; ROK family protein complement(443277..444500) Streptococcus pneumoniae P1031 7681479 YP_002737707.1 CDS SPP_0499 NC_012467.1 444668 445990 D identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) 444668..445990 Streptococcus pneumoniae P1031 7680819 YP_002737708.1 CDS SPP_0500 NC_012467.1 445992 447878 D hypothetical protein 445992..447878 Streptococcus pneumoniae P1031 7680872 YP_002737709.1 CDS SPP_0501 NC_012467.1 448046 448390 D identified by match to protein family HMM PF02255; lactose-specific phosphotransferase enzyme iia component (pts system lactose-specific eiia component) (eiia-lac) (eiii-lac) 448046..448390 Streptococcus pneumoniae P1031 7682525 YP_002737710.1 CDS lacG1 NC_012467.1 448400 449812 D catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 448400..449812 Streptococcus pneumoniae P1031 7682301 YP_002737711.1 CDS SPP_0503 NC_012467.1 449882 451561 D identified by match to protein family HMM PF02302; match to protein family HMM PF02378; pts system lactose-specific eiicb component (eiicb-lac) (eii-lac) 449882..451561 Streptococcus pneumoniae P1031 7682014 YP_002737712.1 CDS SPP_0504 NC_012467.1 451687 453126 R identified by match to protein family HMM PF02386; potassium uptake protein, Trk family complement(451687..453126) Streptococcus pneumoniae P1031 7681201 YP_002737713.1 CDS trkA NC_012467.1 453130 454479 R involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component complement(453130..454479) Streptococcus pneumoniae P1031 7681470 YP_002737714.1 CDS SPP_0506 NC_012467.1 454667 455515 D identified by match to protein family HMM PF01887; hypothetical protein 454667..455515 Streptococcus pneumoniae P1031 7681151 YP_002737715.1 CDS SPP_0507 NC_012467.1 455530 456078 D identified by match to protein family HMM PF07155; hypothetical protein 455530..456078 Streptococcus pneumoniae P1031 7682113 YP_002737716.1 CDS SPP_0508 NC_012467.1 456085 456342 D hypothetical protein 456085..456342 Streptococcus pneumoniae P1031 7681392 YP_002737717.1 CDS SPP_0509 NC_012467.1 456444 458126 D identified by match to protein family HMM PF00005; putative ABC transporter ATP-binding protein 456444..458126 Streptococcus pneumoniae P1031 7681939 YP_002737718.1 CDS SPP_0510 NC_012467.1 458111 458941 D identified by match to protein family HMM PF02361; cobalt transport family protein 458111..458941 Streptococcus pneumoniae P1031 7681586 YP_002737719.1 CDS cspR NC_012467.1 459134 459637 D identified by match to protein family HMM PF00588; CspR 459134..459637 Streptococcus pneumoniae P1031 7680638 YP_002737720.1 CDS SPP_0512 NC_012467.1 460090 460653 D hypothetical protein 460090..460653 Streptococcus pneumoniae P1031 7681258 YP_002737721.1 CDS SPP_0513 NC_012467.1 460667 461293 D identified by match to protein family HMM PF01569; PAP2 family protein 460667..461293 Streptococcus pneumoniae P1031 7681267 YP_002737722.1 CDS SPP_0514 NC_012467.1 461321 461710 D hypothetical protein 461321..461710 Streptococcus pneumoniae P1031 7681976 YP_002737723.1 CDS SPP_0515 NC_012467.1 461715 462164 D hypothetical protein 461715..462164 Streptococcus pneumoniae P1031 7681999 YP_002737724.1 CDS rpoE NC_012467.1 462292 462879 D participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 462292..462879 Streptococcus pneumoniae P1031 7682818 YP_002737725.1 CDS SPP_0517 NC_012467.1 463015 463140 D identified by glimmer; putative; hypothetical protein 463015..463140 Streptococcus pneumoniae P1031 7680799 YP_002737726.1 CDS pyrG NC_012467.1 463269 464876 D CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 463269..464876 Streptococcus pneumoniae P1031 7682380 YP_002737727.1 CDS SPP_0519 NC_012467.1 465435 467066 R identified by match to protein family HMM PF01895; match to protein family HMM PF02690; match to protein family HMM TIGR00704; sodium-dependent phosphate transporter complement(465435..467066) Streptococcus pneumoniae P1031 7681772 YP_002737728.1 CDS SPP_0520 NC_012467.1 467431 472299 D identified by match to protein family HMM PF00746; match to protein family HMM PF00754; match to protein family HMM PF03644; match to protein family HMM PF07501; match to protein family HMM PF07523; match to protein family HMM PF07554; match to protein family HMM TIGR01167; endo-beta-N-acetylglucosaminidase D 467431..472299 Streptococcus pneumoniae P1031 7681109 YP_002737729.1 CDS pgk NC_012467.1 472389 473585 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 472389..473585 Streptococcus pneumoniae P1031 7682040 YP_002737730.1 CDS SPP_0522 NC_012467.1 473721 474248 D hypothetical protein 473721..474248 Streptococcus pneumoniae P1031 7682188 YP_002737731.1 CDS SPP_0523 NC_012467.1 474325 474681 D identified by match to protein family HMM PF00376; HTH-type transcriptional regulator GlnR 474325..474681 Streptococcus pneumoniae P1031 7681141 YP_002737732.1 CDS glnA NC_012467.1 474718 476064 D identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; glutamine synthetase, type I 474718..476064 Streptococcus pneumoniae P1031 7682623 YP_002737733.1 CDS SPP_0525 NC_012467.1 476507 477853 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; identified by match to protein family HMM PF01609; Spn1 transposase complement(476507..477853) Streptococcus pneumoniae P1031 7682870 YP_002737734.1 CDS SPP_0526 NC_012467.1 478239 478376 D hypothetical protein 478239..478376 Streptococcus pneumoniae P1031 7682208 YP_002737735.1 CDS SPP_0527 NC_012467.1 478547 479827 D identified by match to protein family HMM PF01420; type I site-specific deoxyribonuclease chain S 478547..479827 Streptococcus pneumoniae P1031 7682573 YP_002737736.1 CDS SPP_0528 NC_012467.1 479884 480681 D identified by match to protein family HMM PF00589; integrase/recombinase, phage integrase family 479884..480681 Streptococcus pneumoniae P1031 7682284 YP_002737737.1 CDS SPP_0530 NC_012467.1 480692 481297 D type I restriction-modification system, S subunit, putative 480692..481297 Streptococcus pneumoniae P1031 7682531 YP_002737738.1 CDS SPP_0529 NC_012467.1 481245 482795 R identified by match to protein family HMM PF01420; type I restriction enzyme complement(481245..482795) Streptococcus pneumoniae P1031 7681018 YP_002737739.1 CDS SPP_0531 NC_012467.1 482795 484258 R identified by match to protein family HMM PF02384; match to protein family HMM PF05175; type I restriction enzyme complement(482795..484258) Streptococcus pneumoniae P1031 7681215 YP_002737740.1 CDS SPP_0534 NC_012467.1 486955 487083 R hypothetical protein complement(486955..487083) Streptococcus pneumoniae P1031 7681405 YP_002737741.1 CDS SPP_0535 NC_012467.1 487212 487721 D hypothetical protein 487212..487721 Streptococcus pneumoniae P1031 7682445 YP_002737742.1 CDS hrcA NC_012467.1 487885 488919 D Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 487885..488919 Streptococcus pneumoniae P1031 7682288 YP_002737743.1 CDS grpE NC_012467.1 488946 489470 D with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 488946..489470 Streptococcus pneumoniae P1031 7681758 YP_002737744.1 CDS dnaK NC_012467.1 489950 491773 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 489950..491773 Streptococcus pneumoniae P1031 7681541 YP_002737745.1 CDS SPP_0539 NC_012467.1 491786 492139 D identified by glimmer; putative; hypothetical protein 491786..492139 Streptococcus pneumoniae P1031 7681743 YP_002737746.1 CDS dnaJ NC_012467.1 492344 493480 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 492344..493480 Streptococcus pneumoniae P1031 7681727 YP_002737747.1 CDS SPP_0541 NC_012467.1 493802 494176 R chlorohydrolase complement(493802..494176) Streptococcus pneumoniae P1031 7682816 YP_002737748.1 CDS SPP_0542 NC_012467.1 494338 494625 R hypothetical protein complement(494338..494625) Streptococcus pneumoniae P1031 7681837 YP_002737749.1 CDS SPP_0543 NC_012467.1 494635 495045 R identified by match to protein family HMM PF01230; histidine triad domain protein complement(494635..495045) Streptococcus pneumoniae P1031 7681031 YP_002737750.1 CDS SPP_0544 NC_012467.1 495113 495844 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 495113..495844 Streptococcus pneumoniae P1031 7681354 YP_002737751.1 CDS SPP_0545 NC_012467.1 495841 496890 D identified by match to protein family HMM PF05975; ABC transporter permease 495841..496890 Streptococcus pneumoniae P1031 7682378 YP_002737752.1 CDS SPP_0546 NC_012467.1 497058 497387 R BlpT protein, fusion complement(497058..497387) Streptococcus pneumoniae P1031 7682670 YP_002737753.1 CDS SPP_0547 NC_012467.1 497664 498002 D identified by match to protein family HMM PF04397; regulatory protein 497664..498002 Streptococcus pneumoniae P1031 7682534 YP_002737754.1 CDS SPP_0548 NC_012467.1 498007 498744 D identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator 498007..498744 Streptococcus pneumoniae P1031 7681437 YP_002737755.1 CDS SPP_0549 NC_012467.1 498758 500098 D histidine kinase 498758..500098 Streptococcus pneumoniae P1031 7681332 YP_002737756.1 CDS SPP_0550 NC_012467.1 500142 500297 R identified by match to protein family HMM PF08128; match to protein family HMM TIGR01847; double glycine cleavage site bacteriolysin superfamily complement(500142..500297) Streptococcus pneumoniae P1031 7681815 YP_002737757.1 CDS SPP_0551 NC_012467.1 500354 501715 R identified by match to protein family HMM TIGR01000; BlpC ABC transporter complement(500354..501715) Streptococcus pneumoniae P1031 7682384 YP_002737758.1 CDS SPP_0552 NC_012467.1 501726 503879 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193; transport/processing ATP-binding protein ComA complement(501726..503879) Streptococcus pneumoniae P1031 7681988 YP_002737759.1 CDS SPP_0553 NC_012467.1 504161 504415 D identified by match to protein family HMM TIGR01847; BlpM 504161..504415 Streptococcus pneumoniae P1031 7682558 YP_002737760.1 CDS SPP_0554 NC_012467.1 504431 504634 D hypothetical protein 504431..504634 Streptococcus pneumoniae P1031 7682258 YP_002737761.1 CDS SPP_0555 NC_012467.1 504878 505027 D identified by match to protein family HMM TIGR01847; hypothetical protein 504878..505027 Streptococcus pneumoniae P1031 7680679 YP_002737762.1 CDS SPP_0556 NC_012467.1 505009 505128 D hypothetical protein 505009..505128 Streptococcus pneumoniae P1031 7680835 YP_002737763.1 CDS SPP_0557 NC_012467.1 505131 505250 D hypothetical protein 505131..505250 Streptococcus pneumoniae P1031 7682316 YP_002737764.1 CDS SPP_0558 NC_012467.1 505363 505479 D hypothetical protein 505363..505479 Streptococcus pneumoniae P1031 7682308 YP_002737765.1 CDS SPP_0559 NC_012467.1 505547 505708 D hypothetical protein 505547..505708 Streptococcus pneumoniae P1031 7681951 YP_002737766.1 CDS SPP_0561 NC_012467.1 506267 506446 D hypothetical protein 506267..506446 Streptococcus pneumoniae P1031 7681674 YP_002737767.1 CDS SPP_0562 NC_012467.1 506478 506618 D immunity protein BlpL 506478..506618 Streptococcus pneumoniae P1031 7681728 YP_002737768.1 CDS SPP_0563 NC_012467.1 506718 507101 D immunity protein BlpX 506718..507101 Streptococcus pneumoniae P1031 7682100 YP_002737769.1 CDS SPP_0564 NC_012467.1 507153 507842 D identified by match to protein family HMM PF02517; BlpY protein 507153..507842 Streptococcus pneumoniae P1031 7681636 YP_002737770.1 CDS SPP_0566 NC_012467.1 508268 508879 D identified by match to protein family HMM PF02517; ABC transporter ATP-binding protein 508268..508879 Streptococcus pneumoniae P1031 7681237 YP_002737771.1 CDS SPP_0567 NC_012467.1 509040 509834 D identified by match to protein family HMM PF01636; phosphotransferase enzyme family 509040..509834 Streptococcus pneumoniae P1031 7681889 YP_002737772.1 CDS trmB NC_012467.1 509831 510466 D tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 509831..510466 Streptococcus pneumoniae P1031 7680876 YP_002737773.1 CDS SPP_0569 NC_012467.1 510592 511071 D in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 510592..511071 Streptococcus pneumoniae P1031 7681139 YP_002737774.1 CDS nusA NC_012467.1 511115 512251 D modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 511115..512251 Streptococcus pneumoniae P1031 7680812 YP_002737775.1 CDS SPP_0571 NC_012467.1 512273 512566 D identified by match to protein family HMM PF04296; putative chain a, hypothetical cytosolic protein coded by gene from nusainfb, ylxr homologue 512273..512566 Streptococcus pneumoniae P1031 7680901 YP_002737776.1 CDS SPP_0572 NC_012467.1 512559 512858 D identified by match to protein family HMM PF01248; hypothetical protein 512559..512858 Streptococcus pneumoniae P1031 7680951 YP_002737777.1 CDS infB NC_012467.1 512875 515667 D Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 512875..515667 Streptococcus pneumoniae P1031 7681457 YP_002737778.1 CDS rbfA NC_012467.1 515918 516268 D associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 515918..516268 Streptococcus pneumoniae P1031 7681448 YP_002737779.1 CDS SPP_0575 NC_012467.1 516547 517326 D hypothetical protein 516547..517326 Streptococcus pneumoniae P1031 7682522 YP_002737780.1 CDS SPP_0576 NC_012467.1 517328 517510 D hypothetical protein 517328..517510 Streptococcus pneumoniae P1031 7682809 YP_002737781.1 CDS SPP_0577 NC_012467.1 517777 517929 R identified by glimmer; putative; hypothetical protein complement(517777..517929) Streptococcus pneumoniae P1031 7680656 YP_002737782.1 CDS SPP_0578 NC_012467.1 517960 518193 D identified by match to protein family HMM PF08984; hypothetical protein 517960..518193 Streptococcus pneumoniae P1031 7682644 YP_002737783.1 CDS SPP_0579 NC_012467.1 518193 519527 D identified by match to protein family HMM PF01814; match to protein family HMM PF04282; hemerythrin HHE cation binding domain subfamily, putative 518193..519527 Streptococcus pneumoniae P1031 7681611 YP_002737784.1 CDS SPP_0580 NC_012467.1 519537 519791 D identified by match to protein family HMM PF08930; hypothetical protein 519537..519791 Streptococcus pneumoniae P1031 7680904 YP_002737785.1 CDS SPP_0581 NC_012467.1 519887 520282 D hypothetical protein 519887..520282 Streptococcus pneumoniae P1031 7682564 YP_002737786.1 CDS SPP_0582 NC_012467.1 520695 521144 D identified by glimmer; putative; hypothetical protein 520695..521144 Streptococcus pneumoniae P1031 7681208 YP_002737787.1 CDS SPP_0583 NC_012467.1 521131 521691 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 521131..521691 Streptococcus pneumoniae P1031 7682578 YP_002737788.1 CDS SPP_0584 NC_012467.1 521691 522269 D shikimate kinase 521691..522269 Streptococcus pneumoniae P1031 7681713 YP_002737789.1 CDS valS NC_012467.1 522262 524913 D valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 522262..524913 Streptococcus pneumoniae P1031 7682127 YP_002737790.1 CDS SPP_0586 NC_012467.1 524983 525738 D hypothetical protein 524983..525738 Streptococcus pneumoniae P1031 7682453 YP_002737791.1 CDS SPP_0587 NC_012467.1 526013 526816 D identified by match to protein family HMM PF02661; Fic protein family 526013..526816 Streptococcus pneumoniae P1031 7680943 YP_002737792.1 CDS SPP_0589 NC_012467.1 527482 528261 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(527482..528261) Streptococcus pneumoniae P1031 7681833 YP_002737793.1 CDS SPP_0592 NC_012467.1 531431 532270 D identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator LicT 531431..532270 Streptococcus pneumoniae P1031 7682475 YP_002737794.1 CDS SPP_0593 NC_012467.1 532288 534126 D identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00830; match to protein family HMM TIGR01995; pts system beta-glucoside-specific eiibca component (eiibca-bgl) (eii-bgl) 532288..534126 Streptococcus pneumoniae P1031 7681292 YP_002737795.1 CDS SPP_0594 NC_012467.1 534139 535554 D identified by match to protein family HMM PF00232; beta-glucosidase (Gentiobiase) (Cellobiase) (Beta-D-glucoside glucohydrolase) (Amygdalase) 534139..535554 Streptococcus pneumoniae P1031 7680622 YP_002737796.1 CDS pheS NC_012467.1 536104 537192 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 536104..537192 Streptococcus pneumoniae P1031 7681125 YP_002737797.1 CDS SPP_0596 NC_012467.1 537192 537701 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 537192..537701 Streptococcus pneumoniae P1031 7681530 YP_002737798.1 CDS pheT NC_012467.1 537778 540180 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 537778..540180 Streptococcus pneumoniae P1031 7681390 YP_002737799.1 CDS SPP_0598 NC_012467.1 540248 541249 R identified by match to protein family HMM PF03372; endonuclease/exonuclease/phosphatase family complement(540248..541249) Streptococcus pneumoniae P1031 7682849 YP_002737800.1 CDS SPP_0601 NC_012467.1 541978 542244 D identified by match to protein family HMM PF01381; helix-turn-helix domain protein 541978..542244 Streptococcus pneumoniae P1031 7682450 YP_002737801.1 CDS metE NC_012467.1 542504 544753 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 542504..544753 Streptococcus pneumoniae P1031 7681566 YP_002737802.1 CDS metF NC_012467.1 544817 545683 D identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; 5,10-methylenetetrahydrofolate reductase 544817..545683 Streptococcus pneumoniae P1031 7682491 YP_002737803.1 CDS cysE NC_012467.1 548471 549088 D identified by match to protein family HMM TIGR01172; serine O-acetyltransferase 548471..549088 Streptococcus pneumoniae P1031 7681565 YP_002737804.1 CDS SPP_0607 NC_012467.1 549100 549984 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 549100..549984 Streptococcus pneumoniae P1031 7681264 YP_002737805.1 CDS cysS NC_012467.1 550066 551409 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 550066..551409 Streptococcus pneumoniae P1031 7681667 YP_002737806.1 CDS SPP_0609 NC_012467.1 551402 551788 D identified by match to protein family HMM PF00636; ribonuclease III family protein 551402..551788 Streptococcus pneumoniae P1031 7681744 YP_002737807.1 CDS SPP_0610 NC_012467.1 551792 552676 D leucine-rich protein 551792..552676 Streptococcus pneumoniae P1031 7682856 YP_002737808.1 CDS SPP_0611 NC_012467.1 552724 552840 D identified by glimmer; putative; hypothetical protein 552724..552840 Streptococcus pneumoniae P1031 7681584 YP_002737809.1 CDS SPP_0612 NC_012467.1 553047 553412 D identified by glimmer; putative; hypothetical protein 553047..553412 Streptococcus pneumoniae P1031 7682721 YP_002737810.1 CDS SPP_0613 NC_012467.1 553558 553731 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; GBSi1, group II intron, maturase 553558..553731 Streptococcus pneumoniae P1031 7681900 YP_002737811.1 CDS SPP_0614 NC_012467.1 554081 555358 D identified by match to protein family HMM PF02687; peptide ABC transporter permease 554081..555358 Streptococcus pneumoniae P1031 7680710 YP_002737812.1 CDS SPP_0615 NC_012467.1 555371 556018 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 555371..556018 Streptococcus pneumoniae P1031 7682328 YP_002737813.1 CDS SPP_0616 NC_012467.1 556070 557449 D identified by match to protein family HMM PF02687; peptide ABC transporter permease 556070..557449 Streptococcus pneumoniae P1031 7682481 YP_002737814.1 CDS SPP_0617 NC_012467.1 557762 558418 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; VncR, response regulator 557762..558418 Streptococcus pneumoniae P1031 7681248 YP_002737815.1 CDS SPP_0618 NC_012467.1 558415 559743 D identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; VncS, histidine kinase 558415..559743 Streptococcus pneumoniae P1031 7681278 YP_002737816.1 CDS fba NC_012467.1 559884 560765 D catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 559884..560765 Streptococcus pneumoniae P1031 7680948 YP_002737817.1 CDS SPP_0622 NC_012467.1 562524 563183 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamine ABC transporter permease complement(562524..563183) Streptococcus pneumoniae P1031 7681323 YP_002737818.1 CDS SPP_0623 NC_012467.1 563193 563870 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamine ABC transporter permease complement(563193..563870) Streptococcus pneumoniae P1031 7682395 YP_002737819.1 CDS SPP_0624 NC_012467.1 563883 564677 R identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein - glutamine transport/Major cell binding factor complement(563883..564677) Streptococcus pneumoniae P1031 7681486 YP_002737820.1 CDS SPP_0625 NC_012467.1 564688 565446 R identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ complement(564688..565446) Streptococcus pneumoniae P1031 7681899 YP_002737821.1 CDS recJ NC_012467.1 565711 567945 D identified by match to protein family HMM PF01368; match to protein family HMM PF02272; match to protein family HMM TIGR00644; single-stranded-DNA-specific exonuclease RecJ 565711..567945 Streptococcus pneumoniae P1031 7681245 YP_002737822.1 CDS SPP_0627 NC_012467.1 568120 569781 D identified by match to protein family HMM PF00753; match to protein family HMM PF07521; metallo-beta-lactamase family protein 568120..569781 Streptococcus pneumoniae P1031 7680780 YP_002737823.1 CDS SPP_0628 NC_012467.1 569850 570629 D identified by match to protein family HMM PF00756; tributyrin esterase 569850..570629 Streptococcus pneumoniae P1031 7680900 YP_002737824.1 CDS SPP_0629 NC_012467.1 570741 571961 D identified by match to protein family HMM PF02388; serine/alanine-adding enzyme MurM 570741..571961 Streptococcus pneumoniae P1031 7682243 YP_002737825.1 CDS SPP_0630 NC_012467.1 571966 573198 D identified by match to protein family HMM PF02388; alanine adding enzyme 571966..573198 Streptococcus pneumoniae P1031 7681662 YP_002737826.1 CDS SPP_0631 NC_012467.1 573277 573978 D identified by match to protein family HMM PF00413; matrixin family 573277..573978 Streptococcus pneumoniae P1031 7681917 YP_002737827.1 CDS uvrC NC_012467.1 574018 575862 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 574018..575862 Streptococcus pneumoniae P1031 7681613 YP_002737828.1 CDS SPP_0633 NC_012467.1 575852 576649 D identified by match to protein family HMM PF00149; Ser/Thr protein phosphatase family protein 575852..576649 Streptococcus pneumoniae P1031 7682524 YP_002737829.1 CDS SPP_0634 NC_012467.1 576831 577631 R identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein - glutamine transport/Major cell binding factor complement(576831..577631) Streptococcus pneumoniae P1031 7681023 YP_002737830.1 CDS SPP_0635 NC_012467.1 577675 577815 D hypothetical protein 577675..577815 Streptococcus pneumoniae P1031 7680782 YP_002737831.1 CDS SPP_0636 NC_012467.1 577802 578407 D identified by match to protein family HMM PF00881; oxidoreductase 577802..578407 Streptococcus pneumoniae P1031 7681995 YP_002737832.1 CDS pepV NC_012467.1 578420 579820 D divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 578420..579820 Streptococcus pneumoniae P1031 7680669 YP_002737833.1 CDS SPP_0638 NC_012467.1 579874 580452 D identified by match to protein family HMM PF03167; uracil DNA glycosylase family protein 579874..580452 Streptococcus pneumoniae P1031 7682306 YP_002737834.1 CDS SPP_0639 NC_012467.1 580612 580764 D identified by glimmer; putative; hypothetical protein 580612..580764 Streptococcus pneumoniae P1031 7681236 YP_002737835.1 CDS SPP_0640 NC_012467.1 580780 580899 D identified by glimmer; putative; hypothetical protein 580780..580899 Streptococcus pneumoniae P1031 7681888 YP_002737836.1 CDS brnQ NC_012467.1 581070 582395 D identified by match to protein family HMM PF05525; match to protein family HMM TIGR00796; branched-chain amino acid transport system II carrier protein 581070..582395 Streptococcus pneumoniae P1031 7680805 YP_002737837.1 CDS SPP_0642 NC_012467.1 582493 583530 D identified by match to protein family HMM PF05343; peptidase, M42 582493..583530 Streptococcus pneumoniae P1031 7682690 YP_002737838.1 CDS SPP_0643 NC_012467.1 583532 583972 D identified by match to protein family HMM PF01230; HIT family protein 583532..583972 Streptococcus pneumoniae P1031 7681011 YP_002737839.1 CDS SPP_0644 NC_012467.1 583980 584378 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element 583980..584378 Streptococcus pneumoniae P1031 7681745 YP_002737840.1 CDS SPP_0645 NC_012467.1 584395 584784 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 584395..584784 Streptococcus pneumoniae P1031 7680639 YP_002737841.1 CDS SPP_0646 NC_012467.1 584865 585581 D identified by match to protein family HMM PF02557; D-alanyl-D-alanine carboxypeptidase 584865..585581 Streptococcus pneumoniae P1031 7680980 YP_002737842.1 CDS SPP_0647 NC_012467.1 585621 585758 R identified by glimmer; putative; hypothetical protein complement(585621..585758) Streptococcus pneumoniae P1031 7682506 YP_002737843.1 CDS rplK NC_012467.1 585890 586315 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 585890..586315 Streptococcus pneumoniae P1031 7682079 YP_002737844.1 CDS rplA NC_012467.1 586523 587212 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 586523..587212 Streptococcus pneumoniae P1031 7682262 YP_002737845.1 CDS SPP_0650 NC_012467.1 587858 588049 R chlorohydrolase complement(587858..588049) Streptococcus pneumoniae P1031 7680713 YP_002737846.1 CDS SPP_0651 NC_012467.1 589469 590461 D identified by match to protein family HMM PF00005; polysaccharide ABC transporter ATP-binding protein 589469..590461 Streptococcus pneumoniae P1031 7682064 YP_002737847.1 CDS SPP_0652 NC_012467.1 590463 591281 D identified by match to protein family HMM PF06182; membrane protein 590463..591281 Streptococcus pneumoniae P1031 7681519 YP_002737848.1 CDS SPP_0653 NC_012467.1 591283 592068 D identified by match to protein family HMM PF06182; ABC transporter permease 591283..592068 Streptococcus pneumoniae P1031 7681680 YP_002737849.1 CDS SPP_0656 NC_012467.1 592885 593067 R chlorohydrolase complement(592885..593067) Streptococcus pneumoniae P1031 7681340 YP_002737850.1 CDS SPP_0657 NC_012467.1 593300 599731 D identified by match to protein family HMM PF00082; match to protein family HMM PF00746; match to protein family HMM PF02225; match to protein family HMM PF06280; match to protein family HMM TIGR01167; serine protease 593300..599731 Streptococcus pneumoniae P1031 7682724 YP_002737851.1 CDS SPP_0661 NC_012467.1 602119 602595 D identified by match to protein family HMM PF00359; phosphotransferase system sugar-specific EII component 602119..602595 Streptococcus pneumoniae P1031 7682456 YP_002737852.1 CDS SPP_0662 NC_012467.1 602633 602938 D PTS system, galactose-specific IIB component 602633..602938 Streptococcus pneumoniae P1031 7681338 YP_002737853.1 CDS SPP_0663 NC_012467.1 602986 604461 D identified by match to protein family HMM PF03611; phosphotransferase system sugar-specific EII component 602986..604461 Streptococcus pneumoniae P1031 7682278 YP_002737854.1 CDS SPP_0664 NC_012467.1 604487 604633 D chlorohydrolase 604487..604633 Streptococcus pneumoniae P1031 7680701 YP_002737855.1 CDS SPP_0665 NC_012467.1 604721 611422 D identified by match to protein family HMM PF00703; match to protein family HMM PF00746; match to protein family HMM PF02836; match to protein family HMM PF02837; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07532; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-galactosidase 604721..611422 Streptococcus pneumoniae P1031 7682859 YP_002737856.1 CDS SPP_0666 NC_012467.1 611670 612293 R identified by glimmer; putative; hypothetical protein complement(611670..612293) Streptococcus pneumoniae P1031 7682610 YP_002737857.1 CDS SPP_0667 NC_012467.1 612281 612526 R identified by glimmer; putative; hypothetical protein complement(612281..612526) Streptococcus pneumoniae P1031 7681097 YP_002737858.1 CDS SPP_0668 NC_012467.1 612737 613096 R integral membrane protein complement(612737..613096) Streptococcus pneumoniae P1031 7682189 YP_002737859.1 CDS SPP_0674 NC_012467.1 614677 614931 D hypothetical protein 614677..614931 Streptococcus pneumoniae P1031 7681152 YP_002737860.1 CDS SPP_0675 NC_012467.1 614943 616997 D identified by match to protein family HMM PF00999; sodium/hydrogen exchanger family protein 614943..616997 Streptococcus pneumoniae P1031 7682836 YP_002737861.1 CDS SPP_0676 NC_012467.1 617030 617143 R identified by glimmer; putative; hypothetical protein complement(617030..617143) Streptococcus pneumoniae P1031 7682164 YP_002737862.1 CDS SPP_0677 NC_012467.1 617176 618036 D identified by match to protein family HMM PF03631; ribonuclease BN 617176..618036 Streptococcus pneumoniae P1031 7681750 YP_002737863.1 CDS SPP_0678 NC_012467.1 618255 618965 D identified by match to protein family HMM PF02683; cytoChrome c-type biogenesis protein 618255..618965 Streptococcus pneumoniae P1031 7682618 YP_002737864.1 CDS SPP_0679 NC_012467.1 618985 619551 D identified by match to protein family HMM PF00578; match to protein family HMM PF08534; thioredoxin family protein 618985..619551 Streptococcus pneumoniae P1031 7680986 YP_002737865.1 CDS SPP_0680 NC_012467.1 619562 620674 D identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; peptide methionine sulfoxide reductase MsrA/msrB 619562..620674 Streptococcus pneumoniae P1031 7681419 YP_002737866.1 CDS SPP_0681 NC_012467.1 620987 621724 D identified by match to protein family HMM PF00072; match to protein family HMM PF00165; response regulator 620987..621724 Streptococcus pneumoniae P1031 7682659 YP_002737867.1 CDS SPP_0682 NC_012467.1 621721 623412 D identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF02743; match to protein family HMM PF06580; histidine kinase 621721..623412 Streptococcus pneumoniae P1031 7680991 YP_002737868.1 CDS SPP_0683 NC_012467.1 623528 624091 D identified by match to protein family HMM PF04260; match to protein family HMM TIGR01440; hypothetical protein 623528..624091 Streptococcus pneumoniae P1031 7681284 YP_002737869.1 CDS zmpB1 NC_012467.1 624113 629755 D identified by match to protein family HMM PF00746; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM TIGR01167; zinc metalloprotease ZmpB 624113..629755 Streptococcus pneumoniae P1031 7680834 YP_002737870.1 CDS SPP_0685 NC_012467.1 629816 631537 D identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553; chorismate binding enzyme 629816..631537 Streptococcus pneumoniae P1031 7681593 YP_002737871.1 CDS SPP_0686 NC_012467.1 631538 632155 D hypothetical protein 631538..632155 Streptococcus pneumoniae P1031 7681303 YP_002737872.1 CDS SPP_0689 NC_012467.1 633329 634288 D identified by match to protein family HMM PF00480; match to protein family HMM TIGR00744; glucokinase (Glucose kinase) 633329..634288 Streptococcus pneumoniae P1031 7682265 YP_002737873.1 CDS thyA NC_012467.1 634385 635224 D ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 634385..635224 Streptococcus pneumoniae P1031 7680671 YP_002737874.1 CDS SPP_0691 NC_012467.1 635272 635442 R hypothetical protein complement(635272..635442) Streptococcus pneumoniae P1031 7681158 YP_002737875.1 CDS miaA NC_012467.1 635563 636447 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 635563..636447 Streptococcus pneumoniae P1031 7680909 YP_002737876.1 CDS hflX NC_012467.1 636440 637678 D identified by match to protein family HMM PF01926; match to protein family HMM TIGR00231; match to protein family HMM TIGR03156; GTP-binding proten HflX 636440..637678 Streptococcus pneumoniae P1031 7682714 YP_002737877.1 CDS SPP_0694 NC_012467.1 637671 638294 D cystathionine beta-lyase 637671..638294 Streptococcus pneumoniae P1031 7682663 YP_002737878.1 CDS rnz NC_012467.1 638309 639238 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 638309..639238 Streptococcus pneumoniae P1031 7680895 YP_002737879.1 CDS SPP_0696 NC_012467.1 639259 640014 D identified by match to protein family HMM PF00106; match to protein family HMM PF08659; oxidoreductase 639259..640014 Streptococcus pneumoniae P1031 7681298 YP_002737880.1 CDS SPP_0697 NC_012467.1 640068 641036 R identified by match to protein family HMM PF00126; regulatory function on capsule expression complement(640068..641036) Streptococcus pneumoniae P1031 7681594 YP_002737881.1 CDS SPP_0698 NC_012467.1 641040 641309 D identified by match to protein family HMM PF06014; hypothetical protein 641040..641309 Streptococcus pneumoniae P1031 7680626 YP_002737882.1 CDS SPP_0699 NC_012467.1 641309 641689 D identified by match to protein family HMM PF00581; rhodanese family protein 641309..641689 Streptococcus pneumoniae P1031 7682574 YP_002737883.1 CDS SPP_0700 NC_012467.1 641778 642005 D hypothetical protein 641778..642005 Streptococcus pneumoniae P1031 7681216 YP_002737884.1 CDS SPP_0701 NC_012467.1 642045 642770 R identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A, putative complement(642045..642770) Streptococcus pneumoniae P1031 7681148 YP_002737885.1 CDS typA NC_012467.1 642911 644773 D identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394; GTP-binding protein TypA/BipA 642911..644773 Streptococcus pneumoniae P1031 7682233 YP_002737886.1 CDS SPP_0703 NC_012467.1 644793 645047 D hypothetical protein 644793..645047 Streptococcus pneumoniae P1031 7682034 YP_002737887.1 CDS SPP_0704 NC_012467.1 645413 645712 D identified by match to protein family HMM TIGR01653; bacteriocin, lactococcin 972 family 645413..645712 Streptococcus pneumoniae P1031 7681044 YP_002737888.1 CDS SPP_0705 NC_012467.1 645950 647803 D identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; bacteriocin-associated integral membrane protein 645950..647803 Streptococcus pneumoniae P1031 7681954 YP_002737889.1 CDS SPP_0706 NC_012467.1 647805 648446 D identified by match to protein family HMM PF00005; Na+ ABC transporter ATP-binding protein 647805..648446 Streptococcus pneumoniae P1031 7682637 YP_002737890.1 CDS murD NC_012467.1 648550 649902 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 648550..649902 Streptococcus pneumoniae P1031 7681166 YP_002737891.1 CDS murG NC_012467.1 649904 650962 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase 649904..650962 Streptococcus pneumoniae P1031 7682499 YP_002737892.1 CDS SPP_0709 NC_012467.1 650972 652171 D identified by match to protein family HMM PF03799; match to protein family HMM PF08478; cell division protein DivIB 650972..652171 Streptococcus pneumoniae P1031 7681117 YP_002737893.1 CDS pyrF NC_012467.1 652404 653105 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 652404..653105 Streptococcus pneumoniae P1031 7681914 YP_002737894.1 CDS pyrE NC_012467.1 653139 653771 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 653139..653771 Streptococcus pneumoniae P1031 7682840 YP_002737895.1 CDS SPP_0712 NC_012467.1 654232 654354 D identified by glimmer; putative; hypothetical protein 654232..654354 Streptococcus pneumoniae P1031 7681792 YP_002737896.1 CDS SPP_0713 NC_012467.1 654450 655214 D hypothetical protein 654450..655214 Streptococcus pneumoniae P1031 7681057 YP_002737897.1 CDS SPP_0714 NC_012467.1 655214 655966 D lipoprotein, putative 655214..655966 Streptococcus pneumoniae P1031 7681454 YP_002737898.1 CDS SPP_0715 NC_012467.1 655970 656674 D hypothetical protein 655970..656674 Streptococcus pneumoniae P1031 7682566 YP_002737899.1 CDS SPP_0716 NC_012467.1 656671 657318 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 656671..657318 Streptococcus pneumoniae P1031 7681155 YP_002737900.1 CDS SPP_0717 NC_012467.1 657405 658271 R identified by match to protein family HMM PF00497; ABC-type amino acid transport/signal transduction system, periplasmic component/domain protein complement(657405..658271) Streptococcus pneumoniae P1031 7681279 YP_002737901.1 CDS SPP_0722 NC_012467.1 659689 660309 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamine ABC transporter permease complement(659689..660309) Streptococcus pneumoniae P1031 7682493 YP_002737902.1 CDS SPP_0723 NC_012467.1 660584 660730 D hypothetical protein 660584..660730 Streptococcus pneumoniae P1031 7682002 YP_002737903.1 CDS lysS NC_012467.1 660858 662348 D class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 660858..662348 Streptococcus pneumoniae P1031 7681718 YP_002737904.1 CDS lctO NC_012467.1 662973 664109 D identified by match to protein family HMM PF01070; match to protein family HMM TIGR02708; L-lactate oxidase 662973..664109 Streptococcus pneumoniae P1031 7682766 YP_002737905.1 CDS SPP_0727 NC_012467.1 665389 665520 R identified by glimmer; putative; hypothetical protein complement(665389..665520) Streptococcus pneumoniae P1031 7681025 YP_002737906.1 CDS thiM NC_012467.1 665616 666398 D catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 665616..666398 Streptococcus pneumoniae P1031 7680935 YP_002737907.1 CDS thiE1 NC_012467.1 666400 667029 D identified by match to protein family HMM PF02581; match to protein family HMM TIGR00693; thiamine-phosphate pyrophosphorylase 666400..667029 Streptococcus pneumoniae P1031 7682449 YP_002737908.1 CDS SPP_0730 NC_012467.1 667588 668148 D cobalt ABC transporter permease 667588..668148 Streptococcus pneumoniae P1031 7682715 YP_002737909.1 CDS SPP_0731 NC_012467.1 668149 669534 D identified by match to protein family HMM PF00005; cobalt ABC transporter ATP-binding protein 668149..669534 Streptococcus pneumoniae P1031 7682143 YP_002737910.1 CDS SPP_0732 NC_012467.1 669536 670186 D hypothetical protein 669536..670186 Streptococcus pneumoniae P1031 7680813 YP_002737911.1 CDS SPP_0733 NC_012467.1 670197 670889 D identified by match to protein family HMM PF03070; tena/thi-4 family 670197..670889 Streptococcus pneumoniae P1031 7681035 YP_002737912.1 CDS thiW NC_012467.1 670894 671418 D identified by match to protein family HMM TIGR02359; ThiW protein 670894..671418 Streptococcus pneumoniae P1031 7680916 YP_002737913.1 CDS SPP_0735 NC_012467.1 671418 672221 D identified by match to protein family HMM PF02110; hydroxyethylthiazole kinase 671418..672221 Streptococcus pneumoniae P1031 7681647 YP_002737914.1 CDS thiE NC_012467.1 672214 672846 D Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 672214..672846 Streptococcus pneumoniae P1031 7681849 YP_002737915.1 CDS thiD NC_012467.1 673055 673846 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(673055..673846) Streptococcus pneumoniae P1031 7682587 YP_002737916.1 CDS SPP_0738 NC_012467.1 674212 674607 D identified by match to protein family HMM PF03965; match to protein family HMM TIGR02698; copper transport repressor, CopY/TcrY family 674212..674607 Streptococcus pneumoniae P1031 7681164 YP_002737917.1 CDS SPP_0739 NC_012467.1 674618 674989 D hypothetical protein 674618..674989 Streptococcus pneumoniae P1031 7682038 YP_002737918.1 CDS SPP_0740 NC_012467.1 674999 677242 D identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM PF08282; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525; copper-translocating P-type ATPase 674999..677242 Streptococcus pneumoniae P1031 7680823 YP_002737919.1 CDS spxB NC_012467.1 677449 679224 D identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR02720; pyruvate oxidase 677449..679224 Streptococcus pneumoniae P1031 7681180 YP_002737920.1 CDS SPP_0742 NC_012467.1 679335 679682 D identified by match to protein family HMM PF00903; glyoxalase family protein 679335..679682 Streptococcus pneumoniae P1031 7682514 YP_002737921.1 CDS SPP_0743 NC_012467.1 679799 679960 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(679799..679960) Streptococcus pneumoniae P1031 7682067 YP_002737922.1 CDS SPP_0744 NC_012467.1 679954 680388 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(679954..680388) Streptococcus pneumoniae P1031 7681229 YP_002737923.1 CDS SPP_0745 NC_012467.1 680339 680845 R transposase complement(680339..680845) Streptococcus pneumoniae P1031 7681925 YP_002737924.1 CDS SPP_0746 NC_012467.1 680910 681191 D 6-phospho-beta-glucosidase AscB, truncation 680910..681191 Streptococcus pneumoniae P1031 7681994 YP_002737925.1 CDS manA NC_012467.1 681323 682267 D identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218; mannose-6-phosphate isomerase, class I 681323..682267 Streptococcus pneumoniae P1031 7681554 YP_002737926.1 CDS SPP_0750 NC_012467.1 683867 684607 D identified by match to protein family HMM PF00376; match to protein family HMM PF07739; match to protein family HMM PF09278; transcriptional regulator, MerR family 683867..684607 Streptococcus pneumoniae P1031 7681406 YP_002737927.1 CDS SPP_0751 NC_012467.1 684636 685058 R identified by match to protein family HMM PF00293; MutT/nudix family protein complement(684636..685058) Streptococcus pneumoniae P1031 7682339 YP_002737928.1 CDS SPP_0752 NC_012467.1 685111 686286 R identified by match to protein family HMM PF03486; match to protein family HMM TIGR00275; hypothetical protein complement(685111..686286) Streptococcus pneumoniae P1031 7681945 YP_002737929.1 CDS SPP_0753 NC_012467.1 686345 687190 R identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; hypothetical protein complement(686345..687190) Streptococcus pneumoniae P1031 7680779 YP_002737930.1 CDS SPP_0754 NC_012467.1 687315 687872 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 687315..687872 Streptococcus pneumoniae P1031 7681814 YP_002737931.1 CDS SPP_0755 NC_012467.1 687891 688358 D identified by match to protein family HMM PF00383; ComE operon protein 2 687891..688358 Streptococcus pneumoniae P1031 7681686 YP_002737932.1 CDS upp NC_012467.1 688424 689074 D Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 688424..689074 Streptococcus pneumoniae P1031 7682291 YP_002737933.1 CDS clpP NC_012467.1 689248 689838 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 689248..689838 Streptococcus pneumoniae P1031 7682798 YP_002737934.1 CDS SPP_0758 NC_012467.1 689917 690165 D hypothetical protein 689917..690165 Streptococcus pneumoniae P1031 7682042 YP_002737935.1 CDS SPP_0759 NC_012467.1 690266 691426 D identified by match to protein family HMM PF01094; ABC transporter substrate-binding protein - branched chain amino acid transport 690266..691426 Streptococcus pneumoniae P1031 7681075 YP_002737936.1 CDS SPP_0760 NC_012467.1 691513 691626 R identified by glimmer; putative; hypothetical protein complement(691513..691626) Streptococcus pneumoniae P1031 7681377 YP_002737937.1 CDS SPP_0761 NC_012467.1 691694 692563 D identified by match to protein family HMM PF02653; high-affinity branched-chain amino acid transport system permeaseprotein LivH (LIV-I protein H) 691694..692563 Streptococcus pneumoniae P1031 7682487 YP_002737938.1 CDS SPP_0762 NC_012467.1 692567 693523 D identified by match to protein family HMM PF02653; branched-chain amino acid ABC transporter permease 692567..693523 Streptococcus pneumoniae P1031 7681965 YP_002737939.1 CDS SPP_0763 NC_012467.1 693523 694287 D identified by match to protein family HMM PF00005; high-affinity branched-chain amino acid transport ATP-binding proteinlivG (LIV-I protein G) 693523..694287 Streptococcus pneumoniae P1031 7680691 YP_002737940.1 CDS SPP_0764 NC_012467.1 694287 694997 D identified by match to protein family HMM PF00005; high-affinity branched-chain amino acid transport ATP-binding proteinlivF (LIV-I protein F) 694287..694997 Streptococcus pneumoniae P1031 7680854 YP_002737941.1 CDS SPP_0765 NC_012467.1 695305 695961 D identified by match to protein family HMM PF00571; AcuB family protein 695305..695961 Streptococcus pneumoniae P1031 7682268 YP_002737942.1 CDS prfB NC_012467.1 696175 697164 D recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 696175..697164 Streptococcus pneumoniae P1031 7680700 YP_002737943.1 CDS ftsE NC_012467.1 697182 697874 D identified by match to protein family HMM PF00005; match to protein family HMM TIGR02673; cell division ATP-binding protein FtsE 697182..697874 Streptococcus pneumoniae P1031 7681197 YP_002737944.1 CDS SPP_0768 NC_012467.1 697867 698793 D identified by match to protein family HMM PF02687; cell division ABC transporter, permease protein FtsX 697867..698793 Streptococcus pneumoniae P1031 7682533 YP_002737945.1 CDS SPP_0769 NC_012467.1 699079 701259 D identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR02003; pts system, iibc component 699079..701259 Streptococcus pneumoniae P1031 7682060 YP_002737946.1 CDS SPP_0770 NC_012467.1 701311 702126 D identified by match to protein family HMM PF03372; metal-dependent hydrolase 701311..702126 Streptococcus pneumoniae P1031 7681014 YP_002737947.1 CDS SPP_0771 NC_012467.1 702266 703609 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; ATP-dependent RNA helicase 702266..703609 Streptococcus pneumoniae P1031 7682311 YP_002737948.1 CDS metK NC_012467.1 703986 705176 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 703986..705176 Streptococcus pneumoniae P1031 7680822 YP_002737949.1 CDS SPP_0773 NC_012467.1 705729 706664 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 705729..706664 Streptococcus pneumoniae P1031 7682511 YP_002737950.1 CDS holA NC_012467.1 706698 707735 D required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 706698..707735 Streptococcus pneumoniae P1031 7681120 YP_002737951.1 CDS SPP_0775 NC_012467.1 707908 708513 D identified by match to protein family HMM PF00081; match to protein family HMM PF02777; superoxide dismutase [Mn] (General stress protein 24)(GSP24) 707908..708513 Streptococcus pneumoniae P1031 7682053 YP_002737952.1 CDS SPP_0776 NC_012467.1 708669 709199 D identified by match to protein family HMM PF06265; transcriptional regulator 708669..709199 Streptococcus pneumoniae P1031 7682392 YP_002737953.1 CDS SPP_0777 NC_012467.1 709220 710305 D 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 709220..710305 Streptococcus pneumoniae P1031 7681316 YP_002737954.1 CDS SPP_0778 NC_012467.1 710305 710787 D identified by match to protein family HMM PF04892; VanZ family protein 710305..710787 Streptococcus pneumoniae P1031 7682048 YP_002737955.1 CDS SPP_0779 NC_012467.1 710789 712330 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 710789..712330 Streptococcus pneumoniae P1031 7682218 YP_002737956.1 CDS SPP_0780 NC_012467.1 712386 713189 R identified by match to protein family HMM PF00160; peptidyl-prolyl cis-trans isomerase, cyclophilin-type complement(712386..713189) Streptococcus pneumoniae P1031 7681453 YP_002737957.1 CDS SPP_0781 NC_012467.1 713272 713493 R hypothetical protein complement(713272..713493) Streptococcus pneumoniae P1031 7682646 YP_002737958.1 CDS SPP_0782 NC_012467.1 713972 714181 R identified by glimmer; putative; hypothetical protein complement(713972..714181) Streptococcus pneumoniae P1031 7682867 YP_002737959.1 CDS rpsP NC_012467.1 714351 714623 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 714351..714623 Streptococcus pneumoniae P1031 7681813 YP_002737960.1 CDS SPP_0784 NC_012467.1 714643 714882 D hypothetical protein 714643..714882 Streptococcus pneumoniae P1031 7681328 YP_002737961.1 CDS SPP_0785 NC_012467.1 715459 716247 D identified by match to protein family HMM PF00561; hydrolase, alpha/beta fold family, putative 715459..716247 Streptococcus pneumoniae P1031 7680884 YP_002737962.1 CDS rimM NC_012467.1 716278 716796 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 716278..716796 Streptococcus pneumoniae P1031 7680793 YP_002737963.1 CDS trmD NC_012467.1 716786 717505 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 716786..717505 Streptococcus pneumoniae P1031 7681469 YP_002737964.1 CDS SPP_0788 NC_012467.1 717517 717855 D identified by match to protein family HMM PF03477; oxygen-sensitive ribonucleoside-triphosphate reductase 717517..717855 Streptococcus pneumoniae P1031 7680957 YP_002737965.1 CDS SPP_0789 NC_012467.1 717886 718206 R hypothetical protein complement(717886..718206) Streptococcus pneumoniae P1031 7682054 YP_002737966.1 CDS SPP_0791 NC_012467.1 718304 718519 D hypothetical protein 718304..718519 Streptococcus pneumoniae P1031 7680845 YP_002737967.1 CDS SPP_0790 NC_012467.1 718516 718662 R chlorohydrolase complement(718516..718662) Streptococcus pneumoniae P1031 7682300 YP_002737968.1 CDS SPP_0792 NC_012467.1 718725 719261 R identified by match to protein family HMM PF02632; biotin synthase complement(718725..719261) Streptococcus pneumoniae P1031 7681766 YP_002737969.1 CDS gor NC_012467.1 719457 720803 R catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase complement(719457..720803) Streptococcus pneumoniae P1031 7680696 YP_002737970.1 CDS SPP_0794 NC_012467.1 721068 722267 D identified by match to protein family HMM TIGR01730; membrane-fusion protein 721068..722267 Streptococcus pneumoniae P1031 7681198 YP_002737971.1 CDS SPP_0795 NC_012467.1 722251 722952 D identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease protein MacB 722251..722952 Streptococcus pneumoniae P1031 7681017 YP_002737972.1 CDS SPP_0796 NC_012467.1 722954 724213 D identified by match to protein family HMM PF02687; antimicrobial peptide ABC transporter permease 722954..724213 Streptococcus pneumoniae P1031 7682072 YP_002737973.1 CDS metG NC_012467.1 724337 726334 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 724337..726334 Streptococcus pneumoniae P1031 7681502 YP_002737974.1 CDS SPP_0798 NC_012467.1 726755 727075 D identified by match to protein family HMM PF03551; transcriptional regulator, PadR family 726755..727075 Streptococcus pneumoniae P1031 7681699 YP_002737975.1 CDS SPP_0799 NC_012467.1 727079 727894 D hypothetical protein 727079..727894 Streptococcus pneumoniae P1031 7680907 YP_002737976.1 CDS SPP_0800 NC_012467.1 727969 728895 D identified by match to protein family HMM PF00248; oxidoreductase, aldo/keto reductase family protein 727969..728895 Streptococcus pneumoniae P1031 7681597 YP_002737977.1 CDS SPP_0801 NC_012467.1 728995 729231 D hypothetical protein 728995..729231 Streptococcus pneumoniae P1031 7682620 YP_002737978.1 CDS fabG NC_012467.1 729224 729922 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 729224..729922 Streptococcus pneumoniae P1031 7681233 YP_002737979.1 CDS SPP_0803 NC_012467.1 729933 730433 D identified by match to protein family HMM PF00293; MutT/nudix family protein 729933..730433 Streptococcus pneumoniae P1031 7681504 YP_002737980.1 CDS SPP_0804 NC_012467.1 730411 731280 D identified by match to protein family HMM PF02896; PEP-utilizing enzyme family protein 730411..731280 Streptococcus pneumoniae P1031 7681781 YP_002737981.1 CDS SPP_0805 NC_012467.1 731255 731695 D identified by match to protein family HMM PF06171; hypothetical protein 731255..731695 Streptococcus pneumoniae P1031 7681004 YP_002737982.1 CDS SPP_0806 NC_012467.1 731818 734364 D identified by match to protein family HMM PF01433; aminopeptidase N 731818..734364 Streptococcus pneumoniae P1031 7682008 YP_002737983.1 CDS SPP_0807 NC_012467.1 734473 735147 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; transcriptional regulatory protein CiaR 734473..735147 Streptococcus pneumoniae P1031 7681238 YP_002737984.1 CDS SPP_0808 NC_012467.1 735137 736471 D identified by match to protein family HMM PF00512; match to protein family HMM PF02518; sensor protein CiaH 735137..736471 Streptococcus pneumoniae P1031 7681287 YP_002737985.1 CDS SPP_0809 NC_012467.1 736505 736792 R hypothetical protein complement(736505..736792) Streptococcus pneumoniae P1031 7682846 YP_002737986.1 CDS SPP_0810 NC_012467.1 736932 737861 D identified by match to protein family HMM PF01136; protease 736932..737861 Streptococcus pneumoniae P1031 7682544 YP_002737987.1 CDS SPP_0811 NC_012467.1 738061 740511 D unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 738061..740511 Streptococcus pneumoniae P1031 7681742 YP_002737988.1 CDS SPP_0812 NC_012467.1 740521 741771 D identified by match to protein family HMM PF01098; RodA 740521..741771 Streptococcus pneumoniae P1031 7680692 YP_002737989.1 CDS SPP_0813 NC_012467.1 741782 742336 D identified by match to protein family HMM PF01965; match to protein family HMM TIGR01383; 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein 741782..742336 Streptococcus pneumoniae P1031 7682069 YP_002737990.1 CDS SPP_0814 NC_012467.1 742412 742984 D identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; phosphoglycolate phosphatase 742412..742984 Streptococcus pneumoniae P1031 7680953 YP_002737991.1 CDS gyrB NC_012467.1 742999 744945 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 742999..744945 Streptococcus pneumoniae P1031 7682228 YP_002737992.1 CDS ezrA NC_012467.1 745027 746754 D acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 745027..746754 Streptococcus pneumoniae P1031 7681131 YP_002737993.1 CDS SPP_0819 NC_012467.1 749207 749473 D transposase 749207..749473 Streptococcus pneumoniae P1031 7680883 YP_002737994.1 CDS SPP_0821 NC_012467.1 750027 750377 R identified by match to protein family HMM PF05717; transposase complement(750027..750377) Streptococcus pneumoniae P1031 7681429 YP_002737995.1 CDS SPP_0823 NC_012467.1 751057 751329 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 751057..751329 Streptococcus pneumoniae P1031 7681683 YP_002737996.1 CDS SPP_0824 NC_012467.1 751391 751879 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00665; integrase core domain, putative 751391..751879 Streptococcus pneumoniae P1031 7682119 YP_002737997.1 CDS SPP_0825 NC_012467.1 751991 752290 R identified by match to protein family HMM PF08860; hypothetical protein complement(751991..752290) Streptococcus pneumoniae P1031 7682747 YP_002737998.1 CDS SPP_0827 NC_012467.1 752988 753317 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01710; transposase 752988..753317 Streptococcus pneumoniae P1031 7680873 YP_002737999.1 CDS SPP_0828 NC_012467.1 754044 756302 R identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; negative regulator of genetic competence ClpC/mecB complement(754044..756302) Streptococcus pneumoniae P1031 7680778 YP_002738000.1 CDS SPP_0829 NC_012467.1 756531 756761 R identified by match to protein family HMM PF08796; hypothetical protein complement(756531..756761) Streptococcus pneumoniae P1031 7682121 YP_002738001.1 CDS SPP_0830 NC_012467.1 756951 757634 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 756951..757634 Streptococcus pneumoniae P1031 7680677 YP_002738002.1 CDS SPP_0831 NC_012467.1 757634 758368 D identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 757634..758368 Streptococcus pneumoniae P1031 7681614 YP_002738003.1 CDS SPP_0832 NC_012467.1 758501 759379 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 758501..759379 Streptococcus pneumoniae P1031 7681412 YP_002738004.1 CDS SPP_0833 NC_012467.1 759521 760393 D identified by match to protein family HMM PF01256; match to protein family HMM TIGR00196; putative YjeF homolog, C-terminus 759521..760393 Streptococcus pneumoniae P1031 7681288 YP_002738005.1 CDS rpiA NC_012467.1 760675 761358 D Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 760675..761358 Streptococcus pneumoniae P1031 7681767 YP_002738006.1 CDS deoB NC_012467.1 761372 762583 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 761372..762583 Streptococcus pneumoniae P1031 7682332 YP_002738007.1 CDS SPP_0836 NC_012467.1 762585 762995 D identified by match to protein family HMM PF08002; hypothetical protein 762585..762995 Streptococcus pneumoniae P1031 7682439 YP_002738008.1 CDS SPP_0837 NC_012467.1 763143 763952 D catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 763143..763952 Streptococcus pneumoniae P1031 7681204 YP_002738009.1 CDS SPP_0838 NC_012467.1 764428 765159 D hypothetical protein 764428..765159 Streptococcus pneumoniae P1031 7682543 YP_002738010.1 CDS SPP_0839 NC_012467.1 765205 765408 D identified by glimmer; putative; hypothetical protein 765205..765408 Streptococcus pneumoniae P1031 7681402 YP_002738011.1 CDS SPP_0840 NC_012467.1 765433 765945 D hypothetical protein 765433..765945 Streptococcus pneumoniae P1031 7682756 YP_002738012.1 CDS SPP_0841 NC_012467.1 766051 766164 D identified by glimmer; putative; hypothetical protein 766051..766164 Streptococcus pneumoniae P1031 7682411 YP_002738013.1 CDS deoD NC_012467.1 766603 767313 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 766603..767313 Streptococcus pneumoniae P1031 7680663 YP_002738014.1 CDS SPP_0843 NC_012467.1 767336 767860 R topology modulation protein complement(767336..767860) Streptococcus pneumoniae P1031 7681165 YP_002738015.1 CDS rpsT NC_012467.1 767913 768149 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(767913..768149) Streptococcus pneumoniae P1031 7682221 YP_002738016.1 CDS coaA NC_012467.1 768217 769137 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(768217..769137) Streptococcus pneumoniae P1031 7682731 YP_002738017.1 CDS SPP_0846 NC_012467.1 769335 769739 D identified by glimmer; putative; hypothetical protein 769335..769739 Streptococcus pneumoniae P1031 7682070 YP_002738018.1 CDS SPP_0847 NC_012467.1 769955 770536 D identified by match to protein family HMM PF05175; methyltransferase small domain superfamily 769955..770536 Streptococcus pneumoniae P1031 7682393 YP_002738019.1 CDS SPP_0848 NC_012467.1 770533 771810 D Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 770533..771810 Streptococcus pneumoniae P1031 7682414 YP_002738020.1 CDS deoC NC_012467.1 771828 772490 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 771828..772490 Streptococcus pneumoniae P1031 7682624 YP_002738021.1 CDS cdd1 NC_012467.1 772477 772866 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 772477..772866 Streptococcus pneumoniae P1031 7681087 YP_002738022.1 CDS SPP_0851 NC_012467.1 772957 774009 D identified by match to protein family HMM PF02608; lipoprotein 772957..774009 Streptococcus pneumoniae P1031 7681716 YP_002738023.1 CDS SPP_0852 NC_012467.1 774153 775688 D identified by match to protein family HMM PF00005; ribose import ATP-binding protein RbsA 774153..775688 Streptococcus pneumoniae P1031 7682345 YP_002738024.1 CDS SPP_0853 NC_012467.1 775681 776739 D identified by match to protein family HMM PF02653; ribose/galactose ABC transporter permease 775681..776739 Streptococcus pneumoniae P1031 7680947 YP_002738025.1 CDS SPP_0854 NC_012467.1 776742 777698 D identified by match to protein family HMM PF02653; ribose/galactose ABC transporter permease 776742..777698 Streptococcus pneumoniae P1031 7681456 YP_002738026.1 CDS SPP_0855 NC_012467.1 777783 777995 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; transposase 777783..777995 Streptococcus pneumoniae P1031 7681342 YP_002738027.1 CDS SPP_0856 NC_012467.1 778131 778280 D identified by glimmer; putative; hypothetical protein 778131..778280 Streptococcus pneumoniae P1031 7680882 YP_002738028.1 CDS SPP_0857 NC_012467.1 778298 778570 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; hypothetical protein 778298..778570 Streptococcus pneumoniae P1031 7682142 YP_002738029.1 CDS SPP_0858 NC_012467.1 778632 779120 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00665; integrase core domain, putative 778632..779120 Streptococcus pneumoniae P1031 7682226 YP_002738030.1 CDS SPP_0859 NC_012467.1 779165 779806 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY complement(779165..779806) Streptococcus pneumoniae P1031 7680825 YP_002738031.1 CDS parE NC_012467.1 779942 781885 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 779942..781885 Streptococcus pneumoniae P1031 7681915 YP_002738032.1 CDS SPP_0861 NC_012467.1 782006 782131 D identified by glimmer; putative; hypothetical protein 782006..782131 Streptococcus pneumoniae P1031 7680992 YP_002738033.1 CDS parC NC_012467.1 782296 784776 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 782296..784776 Streptococcus pneumoniae P1031 7682309 YP_002738034.1 CDS ilvE NC_012467.1 784908 785930 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 784908..785930 Streptococcus pneumoniae P1031 7681587 YP_002738035.1 CDS SPP_0864 NC_012467.1 785986 786690 D hypothetical protein 785986..786690 Streptococcus pneumoniae P1031 7680922 YP_002738036.1 CDS SPP_0865 NC_012467.1 786755 787444 D identified by match to protein family HMM PF06149; permease 786755..787444 Streptococcus pneumoniae P1031 7681256 YP_002738037.1 CDS SPP_0866 NC_012467.1 787441 788364 D identified by match to protein family HMM PF06166; permease 787441..788364 Streptococcus pneumoniae P1031 7680649 YP_002738038.1 CDS pcp1 NC_012467.1 788379 789023 D catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 788379..789023 Streptococcus pneumoniae P1031 7682640 YP_002738039.1 CDS SPP_0868 NC_012467.1 789191 789421 D hypothetical protein 789191..789421 Streptococcus pneumoniae P1031 7682245 YP_002738040.1 CDS rpsA NC_012467.1 789794 790996 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 789794..790996 Streptococcus pneumoniae P1031 7680760 YP_002738041.1 CDS SPP_0872 NC_012467.1 791082 791579 D GAF domain-containing protein 791082..791579 Streptococcus pneumoniae P1031 7681423 YP_002738042.1 CDS SPP_0873 NC_012467.1 791579 793234 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 791579..793234 Streptococcus pneumoniae P1031 7681578 YP_002738043.1 CDS SPP_0874 NC_012467.1 793286 793456 D hypothetical protein 793286..793456 Streptococcus pneumoniae P1031 7680630 YP_002738044.1 CDS sufC NC_012467.1 793606 794376 D identified by match to protein family HMM PF00005; match to protein family HMM TIGR01978; FeS assembly ATPase SufC 793606..794376 Streptococcus pneumoniae P1031 7681938 YP_002738045.1 CDS sufD NC_012467.1 794404 795666 D identified by match to protein family HMM PF01458; match to protein family HMM TIGR01981; FeS assembly protein SufD 794404..795666 Streptococcus pneumoniae P1031 7680870 YP_002738046.1 CDS SPP_0877 NC_012467.1 795677 796903 D identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM TIGR01979; cysteine desulfurase (Selenocysteine lyase) (Selenocysteine reductase) (Selenocysteine beta-lyase) (SCL) 795677..796903 Streptococcus pneumoniae P1031 7680674 YP_002738047.1 CDS SPP_0878 NC_012467.1 796890 797330 D identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994; SUF system FeS assembly protein, NifU family 796890..797330 Streptococcus pneumoniae P1031 7682273 YP_002738048.1 CDS sufB NC_012467.1 797384 798796 D identified by match to protein family HMM PF01458; match to protein family HMM TIGR01980; FeS assembly protein SufB 797384..798796 Streptococcus pneumoniae P1031 7682058 YP_002738049.1 CDS SPP_0880 NC_012467.1 798995 800236 R identified by match to protein family HMM PF00144; match to protein family HMM PF00768; match to protein family HMM PF07943; D-alanyl-D-alanine carboxypeptidase complement(798995..800236) Streptococcus pneumoniae P1031 7680844 YP_002738050.1 CDS SPP_0881 NC_012467.1 800417 801448 D identified by match to protein family HMM PF01594; membrane protein 800417..801448 Streptococcus pneumoniae P1031 7681523 YP_002738051.1 CDS SPP_0883 NC_012467.1 802873 803613 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; transcriptional repressor of the fructose operon 802873..803613 Streptococcus pneumoniae P1031 7680725 YP_002738052.1 CDS pfkB NC_012467.1 803610 804521 D identified by match to protein family HMM PF00294; match to protein family HMM TIGR03168; 1-phosphofructokinase 803610..804521 Streptococcus pneumoniae P1031 7682196 YP_002738053.1 CDS SPP_0885 NC_012467.1 804518 806470 D identified by match to protein family HMM PF00359; match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR00848; match to protein family HMM TIGR01427; PTS system, Fru family, IIABC 804518..806470 Streptococcus pneumoniae P1031 7682845 YP_002738054.1 CDS SPP_0886 NC_012467.1 806556 808859 D identified by match to protein family HMM PF01580; DNA translocase ftsk 806556..808859 Streptococcus pneumoniae P1031 7682091 YP_002738055.1 CDS SPP_0887 NC_012467.1 809012 809440 R hypothetical protein complement(809012..809440) Streptococcus pneumoniae P1031 7681308 YP_002738056.1 CDS SPP_0888 NC_012467.1 809578 810720 D identified by match to protein family HMM PF00266; cysteine desulfurase 809578..810720 Streptococcus pneumoniae P1031 7681941 YP_002738057.1 CDS thiI NC_012467.1 810729 811943 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 810729..811943 Streptococcus pneumoniae P1031 7682039 YP_002738058.1 CDS SPP_0890 NC_012467.1 812078 812902 D identified by match to protein family HMM PF00756; putative esterase superfamily 812078..812902 Streptococcus pneumoniae P1031 7682755 YP_002738059.1 CDS SPP_0891 NC_012467.1 812915 814081 D carbamoylphosphate synthase large subunit 812915..814081 Streptococcus pneumoniae P1031 7681876 YP_002738060.1 CDS SPP_0892 NC_012467.1 814341 814466 D identified by glimmer; putative; hypothetical protein 814341..814466 Streptococcus pneumoniae P1031 7682812 YP_002738061.1 CDS SPP_0893 NC_012467.1 814589 816082 D identified by match to protein family HMM PF02384; type I restriction modification enzyme methylase subunit 814589..816082 Streptococcus pneumoniae P1031 7682600 YP_002738062.1 CDS SPP_0894 NC_012467.1 816095 817216 D identified by match to protein family HMM PF01420; type I restriction-modification system, S subunit, putative 816095..817216 Streptococcus pneumoniae P1031 7681132 YP_002738063.1 CDS SPP_0895 NC_012467.1 817276 817512 D hypothetical protein 817276..817512 Streptococcus pneumoniae P1031 7682174 YP_002738064.1 CDS SPP_0896 NC_012467.1 817509 817922 D identified by match to protein family HMM PF05012; match to protein family HMM TIGR01550; prophage maintenance system killer protein 817509..817922 Streptococcus pneumoniae P1031 7682340 YP_002738065.1 CDS SPP_0897 NC_012467.1 818040 819005 D identified by match to protein family HMM PF00589; match to protein family HMM PF02899; integrase/recombinase, phage integrase family 818040..819005 Streptococcus pneumoniae P1031 7682036 YP_002738066.1 CDS SPP_0898 NC_012467.1 818971 819609 D identified by match to protein family HMM PF01420; type I restriction-modification enzyme S subunit 818971..819609 Streptococcus pneumoniae P1031 7681299 YP_002738067.1 CDS SPP_0899 NC_012467.1 819639 822989 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04313; match to protein family HMM PF04851; type I restriction-modification system R subunit 819639..822989 Streptococcus pneumoniae P1031 7681785 YP_002738068.1 CDS SPP_0900 NC_012467.1 823260 823460 D chlorohydrolase 823260..823460 Streptococcus pneumoniae P1031 7680643 YP_002738069.1 CDS SPP_0901 NC_012467.1 823575 824045 R identified by match to protein family HMM PF01316; match to protein family HMM PF02863; arginine repressor complement(823575..824045) Streptococcus pneumoniae P1031 7682074 YP_002738070.1 CDS SPP_0902 NC_012467.1 824062 826335 R catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase complement(824062..826335) Streptococcus pneumoniae P1031 7682169 YP_002738071.1 CDS dnaE NC_012467.1 826681 829782 D Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 826681..829782 Streptococcus pneumoniae P1031 7681082 YP_002738072.1 CDS pfkA NC_012467.1 829865 830872 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 829865..830872 Streptococcus pneumoniae P1031 7680698 YP_002738073.1 CDS pyk NC_012467.1 830931 832436 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 830931..832436 Streptococcus pneumoniae P1031 7682804 YP_002738074.1 CDS SPP_0907 NC_012467.1 834187 835059 D lipoprotein, putative 834187..835059 Streptococcus pneumoniae P1031 7681725 YP_002738075.1 CDS SPP_0908 NC_012467.1 835166 835366 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; mobile genetic element complement(835166..835366) Streptococcus pneumoniae P1031 7682684 YP_002738076.1 CDS SPP_0909 NC_012467.1 835367 835549 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; mobile genetic element complement(835367..835549) Streptococcus pneumoniae P1031 7682333 YP_002738077.1 CDS SPP_0910 NC_012467.1 835692 835973 D identified by glimmer; putative; hypothetical protein 835692..835973 Streptococcus pneumoniae P1031 7682744 YP_002738078.1 CDS SPP_0911 NC_012467.1 836008 836724 D hypothetical protein 836008..836724 Streptococcus pneumoniae P1031 7682321 YP_002738079.1 CDS SPP_0912 NC_012467.1 836854 837669 R identified by match to protein family HMM PF09323; ABC transporter substrate-binding protein complement(836854..837669) Streptococcus pneumoniae P1031 7681883 YP_002738080.1 CDS SPP_0913 NC_012467.1 837666 838571 R identified by match to protein family HMM PF03773; membrane protein complement(837666..838571) Streptococcus pneumoniae P1031 7682370 YP_002738081.1 CDS SPP_0914 NC_012467.1 838572 838703 R identified by glimmer; putative; hypothetical protein complement(838572..838703) Streptococcus pneumoniae P1031 7681395 YP_002738082.1 CDS SPP_0915 NC_012467.1 839028 841157 D identified by match to protein family HMM PF00575; S1 RNA binding domain protein 839028..841157 Streptococcus pneumoniae P1031 7681790 YP_002738083.1 CDS SPP_0916 NC_012467.1 841099 841593 D identified by match to protein family HMM PF03926; hypothetical protein 841099..841593 Streptococcus pneumoniae P1031 7681494 YP_002738084.1 CDS SPP_0917 NC_012467.1 841652 841924 D identified by match to protein family HMM PF04024; PspC domain family 841652..841924 Streptococcus pneumoniae P1031 7681161 YP_002738085.1 CDS SPP_0918 NC_012467.1 842897 843655 D identified by match to protein family HMM PF00005; bacitracin export ATP-binding protein BceA 842897..843655 Streptococcus pneumoniae P1031 7682823 YP_002738086.1 CDS SPP_0919 NC_012467.1 843657 845645 D identified by match to protein family HMM PF02687; antimicrobial peptide ABC transporter permease 843657..845645 Streptococcus pneumoniae P1031 7681302 YP_002738087.1 CDS SPP_0920 NC_012467.1 845687 846277 R identified by match to protein family HMM PF01988; integral membrane protein complement(845687..846277) Streptococcus pneumoniae P1031 7682847 YP_002738088.1 CDS SPP_0921 NC_012467.1 846303 847352 R identified by match to protein family HMM PF00665; transposase complement(846303..847352) Streptococcus pneumoniae P1031 7681908 YP_002738089.1 CDS SPP_0922 NC_012467.1 847585 847698 R hypothetical protein complement(847585..847698) Streptococcus pneumoniae P1031 7681409 YP_002738090.1 CDS SPP_0924 NC_012467.1 848059 849534 D identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM PF01276; match to protein family HMM PF03711; arginine decarboxylase 848059..849534 Streptococcus pneumoniae P1031 7682581 YP_002738091.1 CDS SPP_0923 NC_012467.1 849500 849736 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; hypothetical protein complement(849500..849736) Streptococcus pneumoniae P1031 7681382 YP_002738092.1 CDS SPP_0925 NC_012467.1 849688 850215 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(849688..850215) Streptococcus pneumoniae P1031 7682385 YP_002738093.1 CDS speE NC_012467.1 850471 851331 D catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 850471..851331 Streptococcus pneumoniae P1031 7682550 YP_002738094.1 CDS lys NC_012467.1 851328 852587 D identified by match to protein family HMM PF03435; saccharopine dehydrogenase 851328..852587 Streptococcus pneumoniae P1031 7681176 YP_002738095.1 CDS nspC NC_012467.1 852587 853714 D identified by match to protein family HMM PF00278; match to protein family HMM TIGR01047; carboxynorspermidine decarboxylase 852587..853714 Streptococcus pneumoniae P1031 7681844 YP_002738096.1 CDS aguA NC_012467.1 853711 854796 D catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis; agmatine deiminase 853711..854796 Streptococcus pneumoniae P1031 7682830 YP_002738097.1 CDS aguB NC_012467.1 854806 855681 D identified by match to protein family HMM PF00795; match to protein family HMM TIGR03381; N-carbamoylputrescine amidase 854806..855681 Streptococcus pneumoniae P1031 7682592 YP_002738098.1 CDS SPP_0931 NC_012467.1 855862 856671 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(855862..856671) Streptococcus pneumoniae P1031 7682825 YP_002738099.1 CDS SPP_0932 NC_012467.1 857218 857889 D identified by match to protein family HMM PF02517; caax amino protease family 857218..857889 Streptococcus pneumoniae P1031 7680864 YP_002738100.1 CDS SPP_0933 NC_012467.1 857941 858138 R hypothetical protein complement(857941..858138) Streptococcus pneumoniae P1031 7682334 YP_002738101.1 CDS SPP_0934 NC_012467.1 858131 859039 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; regulatory function on capsule expression in group B streptococci 858131..859039 Streptococcus pneumoniae P1031 7681285 YP_002738102.1 CDS lspA NC_012467.1 859036 859497 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 859036..859497 Streptococcus pneumoniae P1031 7681135 YP_002738103.1 CDS SPP_0936 NC_012467.1 859487 860374 D identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase D (rRNA-uridine isomerase D) (rRNA pseudouridylate synthase D) 859487..860374 Streptococcus pneumoniae P1031 7682406 YP_002738104.1 CDS SPP_0937 NC_012467.1 860377 862260 D identified by match to protein family HMM PF00753; match to protein family HMM PF01473; choline binding protein E 860377..862260 Streptococcus pneumoniae P1031 7682325 YP_002738105.1 CDS proB NC_012467.1 862361 863470 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 862361..863470 Streptococcus pneumoniae P1031 7681676 YP_002738106.1 CDS proA NC_012467.1 863480 864742 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 863480..864742 Streptococcus pneumoniae P1031 7682110 YP_002738107.1 CDS proC NC_012467.1 864746 865543 D identified by match to protein family HMM PF01210; match to protein family HMM PF03446; match to protein family HMM PF03807; match to protein family HMM TIGR00112; pyrroline-5-carboxylate reductase 864746..865543 Streptococcus pneumoniae P1031 7682124 YP_002738108.1 CDS tmk NC_012467.1 865763 866401 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 865763..866401 Streptococcus pneumoniae P1031 7682347 YP_002738109.1 CDS SPP_0942 NC_012467.1 866398 867288 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 866398..867288 Streptococcus pneumoniae P1031 7681770 YP_002738110.1 CDS SPP_0943 NC_012467.1 867328 867645 D in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 867328..867645 Streptococcus pneumoniae P1031 7681224 YP_002738111.1 CDS SPP_0944 NC_012467.1 867648 868517 D identified by match to protein family HMM PF00590; match to protein family HMM TIGR00096; hypothetical protein 867648..868517 Streptococcus pneumoniae P1031 7681732 YP_002738112.1 CDS SPP_0945 NC_012467.1 868744 869262 D identified by match to protein family HMM PF08020; hypothetical protein 868744..869262 Streptococcus pneumoniae P1031 7682774 YP_002738113.1 CDS SPP_0947 NC_012467.1 869371 870018 D identified by match to protein family HMM PF06970; phage protein 869371..870018 Streptococcus pneumoniae P1031 7681605 YP_002738114.1 CDS SPP_0946 NC_012467.1 870007 870396 R identified by match to protein family HMM PF01609; transposase (IS4 family) complement(870007..870396) Streptococcus pneumoniae P1031 7682118 YP_002738115.1 CDS trmFO NC_012467.1 871454 872788 D TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 871454..872788 Streptococcus pneumoniae P1031 7682733 YP_002738116.1 CDS pyrH NC_012467.1 872872 873609 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 872872..873609 Streptococcus pneumoniae P1031 7682462 YP_002738117.1 CDS frr NC_012467.1 873618 874175 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 873618..874175 Streptococcus pneumoniae P1031 7681206 YP_002738118.1 CDS SPP_0953 NC_012467.1 874196 875089 D s1 RNA binding domain protein 874196..875089 Streptococcus pneumoniae P1031 7682173 YP_002738119.1 CDS SPP_0954 NC_012467.1 875098 875313 D identified by match to protein family HMM PF06855; hypothetical protein 875098..875313 Streptococcus pneumoniae P1031 7681905 YP_002738120.1 CDS SPP_0955 NC_012467.1 875399 876367 D identified by match to protein family HMM PF02562; PhoH family protein 875399..876367 Streptococcus pneumoniae P1031 7681034 YP_002738121.1 CDS SPP_0956 NC_012467.1 876547 877047 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 876547..877047 Streptococcus pneumoniae P1031 7681846 YP_002738122.1 CDS SPP_0957 NC_012467.1 877050 877277 D identified by glimmer; putative; hypothetical protein 877050..877277 Streptococcus pneumoniae P1031 7682800 YP_002738123.1 CDS SPP_0960 NC_012467.1 878965 879534 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 878965..879534 Streptococcus pneumoniae P1031 7682097 YP_002738124.1 CDS SPP_0961 NC_012467.1 879602 880252 D identified by match to protein family HMM PF00633; match to protein family HMM TIGR00426; match to protein family HMM TIGR01259; competence protein CelA 879602..880252 Streptococcus pneumoniae P1031 7681400 YP_002738125.1 CDS SPP_0962 NC_012467.1 880236 882476 D identified by match to protein family HMM PF03772; match to protein family HMM TIGR00360; match to protein family HMM TIGR00361; DNA internalization-related competence protein ComEC/Rec2 880236..882476 Streptococcus pneumoniae P1031 7681860 YP_002738126.1 CDS SPP_0963 NC_012467.1 882876 883463 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 882876..883463 Streptococcus pneumoniae P1031 7681893 YP_002738127.1 CDS SPP_0964 NC_012467.1 883467 884651 D hypothetical protein 883467..884651 Streptococcus pneumoniae P1031 7680908 YP_002738128.1 CDS infC NC_012467.1 884937 885494 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 884937..885494 Streptococcus pneumoniae P1031 7680993 YP_002738129.1 CDS rpmI NC_012467.1 885527 885727 D identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001; 50S ribosomal protein L35 885527..885727 Streptococcus pneumoniae P1031 7681977 YP_002738130.1 CDS rplT NC_012467.1 885779 886138 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 885779..886138 Streptococcus pneumoniae P1031 7682466 YP_002738131.1 CDS SPP_0968 NC_012467.1 886196 886576 D identified by match to protein family HMM PF00903; lactoylglutathione lyase 886196..886576 Streptococcus pneumoniae P1031 7681241 YP_002738132.1 CDS SPP_0969 NC_012467.1 886826 887626 D responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+); dihydroorotate dehydrogenase electron transfer subunit 886826..887626 Streptococcus pneumoniae P1031 7681272 YP_002738133.1 CDS SPP_0970 NC_012467.1 887637 888575 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 887637..888575 Streptococcus pneumoniae P1031 7681544 YP_002738134.1 CDS SPP_0971 NC_012467.1 888674 890782 D identified by match to protein family HMM PF01473; match to protein family HMM PF01832; endo-beta-N-acetylglucosaminidase 888674..890782 Streptococcus pneumoniae P1031 7681420 YP_002738135.1 CDS SPP_0972 NC_012467.1 890843 892498 R identified by match to protein family HMM PF05670; match to protein family HMM PF05833; fibronectin/fibrinogen binding protein complement(890843..892498) Streptococcus pneumoniae P1031 7681967 YP_002738136.1 CDS SPP_0973 NC_012467.1 892603 893100 D identified by match to protein family HMM PF02130; match to protein family HMM TIGR00043; putative metalloprotease 892603..893100 Streptococcus pneumoniae P1031 7681430 YP_002738137.1 CDS SPP_0974 NC_012467.1 893081 893476 D identified by match to protein family HMM PF01219; diacylglycerol kinase (dagk) (diglyceride kinase)(dgk) 893081..893476 Streptococcus pneumoniae P1031 7680944 YP_002738138.1 CDS era NC_012467.1 893493 894392 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 893493..894392 Streptococcus pneumoniae P1031 7680860 YP_002738139.1 CDS mutM NC_012467.1 894441 895265 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 894441..895265 Streptococcus pneumoniae P1031 7682832 YP_002738140.1 CDS coaE NC_012467.1 895265 895870 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 895265..895870 Streptococcus pneumoniae P1031 7681817 YP_002738141.1 CDS SPP_0978 NC_012467.1 895857 897056 D identified by match to protein family HMM PF07690; multidrug resistance protein MdtG 895857..897056 Streptococcus pneumoniae P1031 7681517 YP_002738142.1 CDS rpmG NC_012467.1 897056 897205 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 897056..897205 Streptococcus pneumoniae P1031 7681451 YP_002738143.1 CDS secG NC_012467.1 897245 897478 D identified by match to protein family HMM PF03840; match to protein family HMM TIGR00810; preprotein translocase subunit SecG 897245..897478 Streptococcus pneumoniae P1031 7680667 YP_002738144.1 CDS rnr NC_012467.1 897580 899934 D identified by match to protein family HMM PF00575; match to protein family HMM PF00773; match to protein family HMM PF08206; match to protein family HMM TIGR00358; match to protein family HMM TIGR02063; ribonuclease R 897580..899934 Streptococcus pneumoniae P1031 7682559 YP_002738145.1 CDS smpB NC_012467.1 899897 900364 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 899897..900364 Streptococcus pneumoniae P1031 7681214 YP_002738146.1 CDS tehB NC_012467.1 900380 901240 D with TehA confers resistance to tellurite; tellurite resistance protein TehB 900380..901240 Streptococcus pneumoniae P1031 7680660 YP_002738147.1 CDS SPP_0984 NC_012467.1 901313 902266 D identified by match to protein family HMM PF06054; competence protein 901313..902266 Streptococcus pneumoniae P1031 7681992 YP_002738148.1 CDS pepF1 NC_012467.1 902285 904087 D identified by match to protein family HMM PF01432; match to protein family HMM PF08439; match to protein family HMM TIGR00181; oligoendopeptidase F 902285..904087 Streptococcus pneumoniae P1031 7682175 YP_002738149.1 CDS SPP_0986 NC_012467.1 904125 904802 D identified by match to protein family HMM PF01596; match to protein family HMM PF08241; O-methyltransferase family protein 904125..904802 Streptococcus pneumoniae P1031 7682305 YP_002738150.1 CDS prsA NC_012467.1 904869 905810 D cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase protein PrsA 904869..905810 Streptococcus pneumoniae P1031 7682237 YP_002738151.1 CDS SPP_0988 NC_012467.1 905927 906268 R transposase, IS3 family complement(905927..906268) Streptococcus pneumoniae P1031 7682244 YP_002738152.1 CDS SPP_0989 NC_012467.1 906268 906459 R transposase complement(906268..906459) Streptococcus pneumoniae P1031 7682661 YP_002738153.1 CDS SPP_0990 NC_012467.1 907029 907649 R identified by match to protein family HMM PF00300; phosphoglycerate mutase complement(907029..907649) Streptococcus pneumoniae P1031 7680826 YP_002738154.1 CDS SPP_0991 NC_012467.1 907649 908131 R identified by match to protein family HMM PF04073; regulatory protein complement(907649..908131) Streptococcus pneumoniae P1031 7680931 YP_002738155.1 CDS SPP_0992 NC_012467.1 908131 908973 R identified by match to protein family HMM PF04018; integral membrane protein complement(908131..908973) Streptococcus pneumoniae P1031 7680990 YP_002738156.1 CDS SPP_0993 NC_012467.1 909068 909868 R identified by match to protein family HMM PF01183; lyzozyme M1 complement(909068..909868) Streptococcus pneumoniae P1031 7681104 YP_002738157.1 CDS glmU NC_012467.1 909964 911391 D forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 909964..911391 Streptococcus pneumoniae P1031 7681088 YP_002738158.1 CDS SPP_0995 NC_012467.1 911401 911946 D identified by match to protein family HMM PF00293; ADP-ribose pyrophosphatase 911401..911946 Streptococcus pneumoniae P1031 7682458 YP_002738159.1 CDS SPP_0996 NC_012467.1 911958 912272 D hypothetical protein 911958..912272 Streptococcus pneumoniae P1031 7682356 YP_002738160.1 CDS mtnN NC_012467.1 912289 912981 D enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 912289..912981 Streptococcus pneumoniae P1031 7681723 YP_002738161.1 CDS SPP_0998 NC_012467.1 913058 913549 D identified by match to protein family HMM PF04394; hypothetical protein 913058..913549 Streptococcus pneumoniae P1031 7682655 YP_002738162.1 CDS SPP_0999 NC_012467.1 913623 914213 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 913623..914213 Streptococcus pneumoniae P1031 7680646 YP_002738163.1 CDS SPP_1000 NC_012467.1 914222 915985 D identified by match to protein family HMM PF03009; glycerophosphoryl diester phosphodiesterase family protein 914222..915985 Streptococcus pneumoniae P1031 7681633 YP_002738164.1 CDS SPP_1001 NC_012467.1 916199 916528 D identified by match to protein family HMM PF01710; transposase 916199..916528 Streptococcus pneumoniae P1031 7681063 YP_002738165.1 CDS SPP_1002 NC_012467.1 916707 916847 D hypothetical protein 916707..916847 Streptococcus pneumoniae P1031 7681857 YP_002738166.1 CDS SPP_1003 NC_012467.1 917008 917208 D hypothetical protein 917008..917208 Streptococcus pneumoniae P1031 7682354 YP_002738167.1 CDS SPP_1004 NC_012467.1 917250 917654 D hypothetical protein 917250..917654 Streptococcus pneumoniae P1031 7682103 YP_002738168.1 CDS SPP_1005 NC_012467.1 917885 918592 D identified by match to protein family HMM PF02683; cytochrome c-type biogenesis protein CcdA 917885..918592 Streptococcus pneumoniae P1031 7681514 YP_002738169.1 CDS SPP_1006 NC_012467.1 918603 919160 D identified by match to protein family HMM PF00578; match to protein family HMM PF08534; thioredoxin family protein 918603..919160 Streptococcus pneumoniae P1031 7682420 YP_002738170.1 CDS SPP_1007 NC_012467.1 919535 920926 D identified by match to protein family HMM PF00324; amino acid permease family protein 919535..920926 Streptococcus pneumoniae P1031 7682784 YP_002738171.1 CDS SPP_1008 NC_012467.1 921069 921986 D identified by match to protein family HMM PF01297; zinc-binding lipoprotein AdcA 921069..921986 Streptococcus pneumoniae P1031 7681393 YP_002738172.1 CDS SPP_1009 NC_012467.1 921994 924525 D identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein B 921994..924525 Streptococcus pneumoniae P1031 7681232 YP_002738173.1 CDS SPP_1010 NC_012467.1 924736 927855 D identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein B 924736..927855 Streptococcus pneumoniae P1031 7680976 YP_002738174.1 CDS SPP_1011 NC_012467.1 928685 929254 D identified by match to protein family HMM PF04270; pneumococcal histidine triad protein E 928685..929254 Streptococcus pneumoniae P1031 7682418 YP_002738175.1 CDS SPP_1012 NC_012467.1 929549 930106 D hypothetical protein 929549..930106 Streptococcus pneumoniae P1031 7681309 YP_002738176.1 CDS pepT NC_012467.1 930142 931365 R catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T complement(930142..931365) Streptococcus pneumoniae P1031 7680914 YP_002738177.1 CDS mscL NC_012467.1 932535 932912 R identified by match to protein family HMM PF01741; match to protein family HMM TIGR00220; large conductance mechanosensitive channel protein complement(932535..932912) Streptococcus pneumoniae P1031 7682831 YP_002738178.1 CDS SPP_1017 NC_012467.1 932994 933425 R identified by match to protein family HMM PF04138; MesH protein complement(932994..933425) Streptococcus pneumoniae P1031 7681477 YP_002738179.1 CDS SPP_1018 NC_012467.1 933548 934057 D identified by match to protein family HMM PF06177; citrulline cluster-linked protein 933548..934057 Streptococcus pneumoniae P1031 7682538 YP_002738180.1 CDS asd NC_012467.1 934571 935647 D catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 934571..935647 Streptococcus pneumoniae P1031 7680723 YP_002738181.1 CDS dapA NC_012467.1 935703 936638 D catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 935703..936638 Streptococcus pneumoniae P1031 7681311 YP_002738182.1 CDS trmE NC_012467.1 936685 938058 R in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE complement(936685..938058) Streptococcus pneumoniae P1031 7682536 YP_002738183.1 CDS SPP_1023 NC_012467.1 938195 938377 R 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase complement(938195..938377) Streptococcus pneumoniae P1031 7681629 YP_002738184.1 CDS tdk NC_012467.1 938500 939099 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 938500..939099 Streptococcus pneumoniae P1031 7680975 YP_002738185.1 CDS SPP_1025 NC_012467.1 939089 939568 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 939089..939568 Streptococcus pneumoniae P1031 7681585 YP_002738186.1 CDS prfA NC_012467.1 939578 940657 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 939578..940657 Streptococcus pneumoniae P1031 7681078 YP_002738187.1 CDS hemK NC_012467.1 940657 941496 D identified by match to protein family HMM PF05175; match to protein family HMM PF08241; match to protein family HMM PF08242; match to protein family HMM TIGR00536; match to protein family HMM TIGR03387; protein-(glutamine-N5) methyltransferase, release factor-specific 940657..941496 Streptococcus pneumoniae P1031 7682437 YP_002738188.1 CDS SPP_1028 NC_012467.1 941480 942082 D identified by match to protein family HMM PF01300; match to protein family HMM TIGR00057; Sua5/YciO/YrdC/YwlC family protein 941480..942082 Streptococcus pneumoniae P1031 7682448 YP_002738189.1 CDS SPP_1029 NC_012467.1 942084 942515 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family protein 942084..942515 Streptococcus pneumoniae P1031 7681978 YP_002738190.1 CDS glyA NC_012467.1 942577 943833 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 942577..943833 Streptococcus pneumoniae P1031 7681277 YP_002738191.1 CDS SPP_1031 NC_012467.1 943841 944815 D hypothetical protein 943841..944815 Streptococcus pneumoniae P1031 7682088 YP_002738192.1 CDS SPP_1032 NC_012467.1 944815 945429 D pneumococcal vaccine antigen A 944815..945429 Streptococcus pneumoniae P1031 7680645 YP_002738193.1 CDS SPP_1033 NC_012467.1 945503 946477 D identified by match to protein family HMM PF06207; hypothetical protein 945503..946477 Streptococcus pneumoniae P1031 7682279 YP_002738194.1 CDS rumA1 NC_012467.1 946551 948182 D identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA 946551..948182 Streptococcus pneumoniae P1031 7681271 YP_002738195.1 CDS SPP_1035 NC_012467.1 948920 949138 D hypothetical protein 948920..949138 Streptococcus pneumoniae P1031 7682760 YP_002738196.1 CDS SPP_1036 NC_012467.1 949531 950556 D identified by match to protein family HMM PF01497; ABC transporter substrate-binding protein - iron transport 949531..950556 Streptococcus pneumoniae P1031 7681101 YP_002738197.1 CDS SPP_1037 NC_012467.1 950546 951553 D identified by match to protein family HMM PF01032; iron-compound ABC transporter, permease protein 950546..951553 Streptococcus pneumoniae P1031 7681444 YP_002738198.1 CDS SPP_1038 NC_012467.1 951553 952560 D identified by match to protein family HMM PF01032; Fe3+ ABC transporter permease 951553..952560 Streptococcus pneumoniae P1031 7682352 YP_002738199.1 CDS SPP_1039 NC_012467.1 952560 953354 D identified by match to protein family HMM PF00005; ferric enterobactin transport ATP-binding protein FepC 952560..953354 Streptococcus pneumoniae P1031 7681753 YP_002738200.1 CDS SPP_1040 NC_012467.1 954280 954411 D hypothetical protein 954280..954411 Streptococcus pneumoniae P1031 7681380 YP_002738201.1 CDS SPP_1041 NC_012467.1 955095 955256 D hypothetical protein 955095..955256 Streptococcus pneumoniae P1031 7681511 YP_002738202.1 CDS SPP_1044 NC_012467.1 957295 957861 D hypothetical protein 957295..957861 Streptococcus pneumoniae P1031 7681337 YP_002738203.1 CDS SPP_1045 NC_012467.1 958184 958372 D hypothetical protein 958184..958372 Streptococcus pneumoniae P1031 7681903 YP_002738204.1 CDS SPP_1046 NC_012467.1 958434 959192 D identified by glimmer; putative; hypothetical protein 958434..959192 Streptococcus pneumoniae P1031 7680919 YP_002738205.1 CDS SPP_1047 NC_012467.1 959250 960104 D identified by match to protein family HMM PF03747; ADP-ribosylation/Crystallin J1 959250..960104 Streptococcus pneumoniae P1031 7682290 YP_002738206.1 CDS SPP_1048 NC_012467.1 960216 961100 D identified by match to protein family HMM PF00781; match to protein family HMM TIGR00147; hypothetical protein 960216..961100 Streptococcus pneumoniae P1031 7682683 YP_002738207.1 CDS SPP_1051 NC_012467.1 963275 963730 D identified by glimmer; putative; hypothetical protein 963275..963730 Streptococcus pneumoniae P1031 7682183 YP_002738208.1 CDS SPP_1052 NC_012467.1 963870 963983 D hypothetical protein 963870..963983 Streptococcus pneumoniae P1031 7681651 YP_002738209.1 CDS SPP_1053 NC_012467.1 964173 964649 D identified by match to protein family HMM PF01381; helix-turn-helix domain protein 964173..964649 Streptococcus pneumoniae P1031 7681800 YP_002738210.1 CDS SPP_1054 NC_012467.1 964649 965410 D identified by match to protein family HMM PF06414; signal recognition particle GTPase 964649..965410 Streptococcus pneumoniae P1031 7681231 YP_002738211.1 CDS SPP_1055 NC_012467.1 965438 966595 D hypothetical protein 965438..966595 Streptococcus pneumoniae P1031 7681940 YP_002738212.1 CDS SPP_1056 NC_012467.1 967414 967773 D hypothetical protein 967414..967773 Streptococcus pneumoniae P1031 7682441 YP_002738213.1 CDS SPP_1062 NC_012467.1 971152 972021 D identified by match to protein family HMM PF03446; NAD binding domain of 6-phosphogluconate dehydrogenase family 971152..972021 Streptococcus pneumoniae P1031 7681081 YP_002738214.1 CDS SPP_1063 NC_012467.1 972008 972730 D identified by glimmer; putative; hypothetical protein 972008..972730 Streptococcus pneumoniae P1031 7681782 YP_002738215.1 CDS SPP_1064 NC_012467.1 972727 973257 D hypothetical protein 972727..973257 Streptococcus pneumoniae P1031 7682745 YP_002738216.1 CDS SPP_1065 NC_012467.1 973261 974355 D identified by glimmer; putative; hypothetical protein 973261..974355 Streptococcus pneumoniae P1031 7682611 YP_002738217.1 CDS SPP_1066 NC_012467.1 974358 975029 D identified by glimmer; putative; hypothetical protein 974358..975029 Streptococcus pneumoniae P1031 7682850 YP_002738218.1 CDS galE1 NC_012467.1 975031 976059 D identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase 975031..976059 Streptococcus pneumoniae P1031 7682507 YP_002738219.1 CDS SPP_1068 NC_012467.1 976083 977327 D biotin carboxylase 976083..977327 Streptococcus pneumoniae P1031 7681373 YP_002738220.1 CDS SPP_1071 NC_012467.1 979220 979441 D identified by match to protein family HMM PF01381; hypothetical protein 979220..979441 Streptococcus pneumoniae P1031 7682685 YP_002738221.1 CDS SPP_1072 NC_012467.1 979889 980083 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; mobile genetic element 979889..980083 Streptococcus pneumoniae P1031 7681290 YP_002738222.1 CDS SPP_1073 NC_012467.1 980347 981576 D identified by match to protein family HMM PF01098; cell division protein FtsW 980347..981576 Streptococcus pneumoniae P1031 7681179 YP_002738223.1 CDS ppc NC_012467.1 981596 984292 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 981596..984292 Streptococcus pneumoniae P1031 7681834 YP_002738224.1 CDS SPP_1075 NC_012467.1 984705 985709 D identified by match to protein family HMM PF04392; ABC transporter substrate-binding protein 984705..985709 Streptococcus pneumoniae P1031 7681223 YP_002738225.1 CDS SPP_1076 NC_012467.1 985778 986644 D identified by match to protein family HMM PF02653; ABC transporter 985778..986644 Streptococcus pneumoniae P1031 7682549 YP_002738226.1 CDS SPP_1077 NC_012467.1 986641 987399 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 986641..987399 Streptococcus pneumoniae P1031 7682727 YP_002738227.1 CDS dnaG NC_012467.1 987489 989249 D synthesizes RNA primers at the replication forks; DNA primase 987489..989249 Streptococcus pneumoniae P1031 7681190 YP_002738228.1 CDS SPP_1079 NC_012467.1 989252 990361 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 989252..990361 Streptococcus pneumoniae P1031 7680672 YP_002738229.1 CDS SPP_1080 NC_012467.1 990375 990704 D identified by match to protein family HMM PF01883; N-6 Adenine-specific DNA methylase YitW 990375..990704 Streptococcus pneumoniae P1031 7682269 YP_002738230.1 CDS SPP_1081 NC_012467.1 990819 991862 D identified by match to protein family HMM PF00534; glycosyl transferase CpoA 990819..991862 Streptococcus pneumoniae P1031 7680849 YP_002738231.1 CDS SPP_1082 NC_012467.1 991878 993203 D identified by match to protein family HMM PF00534; glycosyl transferase, group 1 991878..993203 Streptococcus pneumoniae P1031 7682065 YP_002738232.1 CDS SPP_1083 NC_012467.1 993234 993410 D identified by match to protein family HMM PF04024; hypothetical protein 993234..993410 Streptococcus pneumoniae P1031 7681016 YP_002738233.1 CDS SPP_1084 NC_012467.1 993469 993603 D hypothetical protein 993469..993603 Streptococcus pneumoniae P1031 7680926 YP_002738234.1 CDS obgE NC_012467.1 993673 994977 D essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 993673..994977 Streptococcus pneumoniae P1031 7680966 YP_002738235.1 CDS SPP_1086 NC_012467.1 994987 995145 D hypothetical protein 994987..995145 Streptococcus pneumoniae P1031 7682303 YP_002738236.1 CDS murA1 NC_012467.1 996195 997454 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 996195..997454 Streptococcus pneumoniae P1031 7680796 YP_002738237.1 CDS SPP_1088 NC_012467.1 997470 998021 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family protein 997470..998021 Streptococcus pneumoniae P1031 7680659 YP_002738238.1 CDS SPP_1089 NC_012467.1 998014 999291 D identified by match to protein family HMM PF00571; match to protein family HMM PF07085; match to protein family HMM PF08279; cytosolic protein containing multiple CBS domains 998014..999291 Streptococcus pneumoniae P1031 7682248 YP_002738239.1 CDS map NC_012467.1 999307 1000167 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 999307..1000167 Streptococcus pneumoniae P1031 7682553 YP_002738240.1 CDS SPP_1091 NC_012467.1 1000547 1000966 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element 1000547..1000966 Streptococcus pneumoniae P1031 7681168 YP_002738241.1 CDS SPP_1092 NC_012467.1 1000963 1001352 D identified by match to protein family HMM PF01609; transposase (IS4 family) 1000963..1001352 Streptococcus pneumoniae P1031 7680776 YP_002738242.1 CDS pcrA NC_012467.1 1001543 1003834 D identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073; ATP-dependent DNA helicase PcrA 1001543..1003834 Streptococcus pneumoniae P1031 7681263 YP_002738243.1 CDS radC NC_012467.1 1003877 1004557 D Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 1003877..1004557 Streptococcus pneumoniae P1031 7682400 YP_002738244.1 CDS SPP_1094 NC_012467.1 1004554 1005243 R identified by match to protein family HMM PF00117; match to protein family HMM PF07722; glutamine amidotransferase, class I complement(1004554..1005243) Streptococcus pneumoniae P1031 7681892 YP_002738245.1 CDS SPP_1096 NC_012467.1 1005261 1005902 R modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex complement(1005261..1005902) Streptococcus pneumoniae P1031 7681033 YP_002738246.1 CDS SPP_1097 NC_012467.1 1005985 1006200 R hypothetical protein complement(1005985..1006200) Streptococcus pneumoniae P1031 7682765 YP_002738247.1 CDS SPP_1098 NC_012467.1 1006208 1006555 R identified by match to protein family HMM PF08866; hypothetical protein complement(1006208..1006555) Streptococcus pneumoniae P1031 7681280 YP_002738248.1 CDS SPP_1099 NC_012467.1 1006560 1007675 R identified by match to protein family HMM PF00266; cysteine desulfurase complement(1006560..1007675) Streptococcus pneumoniae P1031 7680850 YP_002738249.1 CDS SPP_1100 NC_012467.1 1007685 1008644 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1007685..1008644) Streptococcus pneumoniae P1031 7681127 YP_002738250.1 CDS SPP_1101 NC_012467.1 1008757 1009326 R identified by match to protein family HMM PF01928; adenylate cyclase complement(1008757..1009326) Streptococcus pneumoniae P1031 7681411 YP_002738251.1 CDS SPP_1102 NC_012467.1 1009454 1010125 D identified by match to protein family HMM PF04607; GTP pyrophosphokinase 1009454..1010125 Streptococcus pneumoniae P1031 7681581 YP_002738252.1 CDS ppnK NC_012467.1 1010109 1010927 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1010109..1010927 Streptococcus pneumoniae P1031 7680633 YP_002738253.1 CDS SPP_1104 NC_012467.1 1010924 1011820 D identified by match to protein family HMM PF00849; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase, RluD subfamily 1010924..1011820 Streptococcus pneumoniae P1031 7681512 YP_002738254.1 CDS eutD NC_012467.1 1011864 1012838 D in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 1011864..1012838 Streptococcus pneumoniae P1031 7682446 YP_002738255.1 CDS SPP_1108 NC_012467.1 1014450 1014749 R identified by match to protein family HMM PF02575; match to protein family HMM TIGR00103; hypothetical protein complement(1014450..1014749) Streptococcus pneumoniae P1031 7681463 YP_002738256.1 CDS rplU NC_012467.1 1016036 1016350 D identified by match to protein family HMM PF00829; match to protein family HMM TIGR00061; 50S ribosomal protein L21 1016036..1016350 Streptococcus pneumoniae P1031 7682179 YP_002738257.1 CDS SPP_1111 NC_012467.1 1016366 1016710 D identified by match to protein family HMM PF04327; hypothetical protein 1016366..1016710 Streptococcus pneumoniae P1031 7681111 YP_002738258.1 CDS rpmA NC_012467.1 1016727 1017020 D involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1016727..1017020 Streptococcus pneumoniae P1031 7681601 YP_002738259.1 CDS SPP_1113 NC_012467.1 1017366 1017536 R identified by glimmer; putative; hypothetical protein complement(1017366..1017536) Streptococcus pneumoniae P1031 7681714 YP_002738260.1 CDS SPP_1114 NC_012467.1 1017508 1017636 R hypothetical protein complement(1017508..1017636) Streptococcus pneumoniae P1031 7680881 YP_002738261.1 CDS ribF NC_012467.1 1017973 1018890 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1017973..1018890 Streptococcus pneumoniae P1031 7681039 YP_002738262.1 CDS SPP_1116 NC_012467.1 1018983 1019831 R identified by match to protein family HMM PF02588; hypothetical protein complement(1018983..1019831) Streptococcus pneumoniae P1031 7682033 YP_002738263.1 CDS SPP_1117 NC_012467.1 1019973 1020812 D identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; hypothetical protein 1019973..1020812 Streptococcus pneumoniae P1031 7681958 YP_002738264.1 CDS SPP_1118 NC_012467.1 1020919 1021194 D identified by match to protein family HMM PF00216; DNA-binding protein HU 1 (DNA-binding protein II) (HB) 1020919..1021194 Streptococcus pneumoniae P1031 7682489 YP_002738265.1 CDS SPP_1119 NC_012467.1 1021621 1023522 D identified by match to protein family HMM PF00005; ATPase component of ABC transporter with duplicated ATPase domains 1021621..1023522 Streptococcus pneumoniae P1031 7682613 YP_002738266.1 CDS SPP_1120 NC_012467.1 1023525 1024388 D identified by match to protein family HMM TIGR01716; transcriptional regulator 1023525..1024388 Streptococcus pneumoniae P1031 7682835 YP_002738267.1 CDS SPP_1121 NC_012467.1 1024468 1025646 D identified by match to protein family HMM PF07690; macrolide ABC transporter permease 1024468..1025646 Streptococcus pneumoniae P1031 7681108 YP_002738268.1 CDS ligA NC_012467.1 1025739 1027697 D this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1025739..1027697 Streptococcus pneumoniae P1031 7682167 YP_002738269.1 CDS pulA NC_012467.1 1027809 1030088 D identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02104; pullulanase, type I 1027809..1030088 Streptococcus pneumoniae P1031 7681365 YP_002738270.1 CDS SPP_1124 NC_012467.1 1030440 1030613 R hypothetical protein complement(1030440..1030613) Streptococcus pneumoniae P1031 7681009 YP_002738271.1 CDS SPP_1125 NC_012467.1 1030632 1032056 D identified by match to protein family HMM PF00171; NADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1030632..1032056 Streptococcus pneumoniae P1031 7682837 YP_002738272.1 CDS glgB NC_012467.1 1032539 1034467 D catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 1032539..1034467 Streptococcus pneumoniae P1031 7682598 YP_002738273.1 CDS glgC NC_012467.1 1034457 1035599 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1034457..1035599 Streptococcus pneumoniae P1031 7681334 YP_002738274.1 CDS glgD NC_012467.1 1035589 1036728 D identified by match to protein family HMM PF00483; match to protein family HMM TIGR02092; glucose-1-phosphate adenylyltransferase, GlgD subunit 1035589..1036728 Streptococcus pneumoniae P1031 7680877 YP_002738275.1 CDS glgA NC_012467.1 1036725 1038158 D catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 1036725..1038158 Streptococcus pneumoniae P1031 7682488 YP_002738276.1 CDS SPP_1132 NC_012467.1 1038871 1039986 D identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase 1038871..1039986 Streptococcus pneumoniae P1031 7680644 YP_002738277.1 CDS SPP_1131 NC_012467.1 1039983 1040429 R identified by match to protein family HMM PF07997; hypothetical protein complement(1039983..1040429) Streptococcus pneumoniae P1031 7682253 YP_002738278.1 CDS eno NC_012467.1 1040593 1041897 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1040593..1041897 Streptococcus pneumoniae P1031 7680945 YP_002738279.1 CDS SPP_1134 NC_012467.1 1042035 1042415 R identified by match to protein family HMM PF00589; integrase/recombinase, phage integrase family protein complement(1042035..1042415) Streptococcus pneumoniae P1031 7681492 YP_002738280.1 CDS SPP_1135 NC_012467.1 1042717 1042845 D identified by glimmer; putative; hypothetical protein 1042717..1042845 Streptococcus pneumoniae P1031 7682500 YP_002738281.1 CDS SPP_1136 NC_012467.1 1042864 1043214 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01710; transposase complement(1042864..1043214) Streptococcus pneumoniae P1031 7681635 YP_002738282.1 CDS rexB NC_012467.1 1043740 1047015 D identified by match to protein family HMM TIGR02774; ATP-dependent nuclease subunit B 1043740..1047015 Streptococcus pneumoniae P1031 7682390 YP_002738283.1 CDS addA NC_012467.1 1047012 1050662 D identified by match to protein family HMM PF00580; match to protein family HMM TIGR02785; recombination helicase AddA 1047012..1050662 Streptococcus pneumoniae P1031 7682693 YP_002738284.1 CDS SPP_1139 NC_012467.1 1050877 1052055 D hypothetical protein 1050877..1052055 Streptococcus pneumoniae P1031 7680816 YP_002738285.1 CDS SPP_1140 NC_012467.1 1052264 1058743 D identified by match to protein family HMM PF00089; match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM PF07581; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; IgA1 protease 1052264..1058743 Streptococcus pneumoniae P1031 7681798 YP_002738286.1 CDS zmpB2 NC_012467.1 1058787 1064000 D identified by match to protein family HMM PF00746; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM TIGR01167; zinc metalloprotease ZmpB 1058787..1064000 Streptococcus pneumoniae P1031 7682796 YP_002738287.1 CDS SPP_1142 NC_012467.1 1064005 1064190 R identified by glimmer; putative; hypothetical protein complement(1064005..1064190) Streptococcus pneumoniae P1031 7681869 YP_002738288.1 CDS SPP_1143 NC_012467.1 1064530 1064703 D hypothetical protein 1064530..1064703 Streptococcus pneumoniae P1031 7681260 YP_002738289.1 CDS SPP_1144 NC_012467.1 1064700 1065479 D identified by match to protein family HMM PF06970; replication initiator protein A (RepA) N-terminus 1064700..1065479 Streptococcus pneumoniae P1031 7681300 YP_002738290.1 CDS SPP_1145 NC_012467.1 1065578 1066936 D identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675; methyl transferase 1065578..1066936 Streptococcus pneumoniae P1031 7681539 YP_002738291.1 CDS SPP_1146 NC_012467.1 1066920 1067369 D hypothetical protein 1066920..1067369 Streptococcus pneumoniae P1031 7682027 YP_002738292.1 CDS SPP_1147 NC_012467.1 1067362 1067742 D hypothetical protein 1067362..1067742 Streptococcus pneumoniae P1031 7682719 YP_002738293.1 CDS SPP_1148 NC_012467.1 1067755 1067988 D hypothetical protein 1067755..1067988 Streptococcus pneumoniae P1031 7682211 YP_002738294.1 CDS SPP_1149 NC_012467.1 1068132 1068593 D identified by match to protein family HMM PF02517; caax amino protease family 1068132..1068593 Streptococcus pneumoniae P1031 7682367 YP_002738295.1 CDS SPP_1150 NC_012467.1 1068755 1069972 R identified by match to protein family HMM PF00589; match to protein family HMM PF02920; transposase complement(1068755..1069972) Streptococcus pneumoniae P1031 7680920 YP_002738296.1 CDS SPP_1151 NC_012467.1 1070054 1070257 R identified by match to protein family HMM PF09035; hypothetical protein complement(1070054..1070257) Streptococcus pneumoniae P1031 7682176 YP_002738297.1 CDS SPP_1152 NC_012467.1 1070945 1071367 R identified by match to protein family HMM PF04545; match to protein family HMM PF08281; sigma-70, region 4 family complement(1070945..1071367) Streptococcus pneumoniae P1031 7681137 YP_002738298.1 CDS SPP_1153 NC_012467.1 1071400 1071516 D identified by glimmer; putative; hypothetical protein 1071400..1071516 Streptococcus pneumoniae P1031 7682758 YP_002738299.1 CDS SPP_1154 NC_012467.1 1071872 1072225 D identified by match to protein family HMM PF01381; transcriptional regulator, putative 1071872..1072225 Streptococcus pneumoniae P1031 7681678 YP_002738300.1 CDS SPP_1155 NC_012467.1 1072571 1074490 R identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM PF03764; match to protein family HMM TIGR00231; tetracycline resistance protein TetM complement(1072571..1074490) Streptococcus pneumoniae P1031 7682206 YP_002738301.1 CDS SPP_1156 NC_012467.1 1074506 1074622 R regulates the transcription of tet(M) by attenuation; tetracycline resistance determinant leader peptide complement(1074506..1074622) Streptococcus pneumoniae P1031 7681142 YP_002738302.1 CDS SPP_1157 NC_012467.1 1074867 1075784 R conjugative transposon protein complement(1074867..1075784) Streptococcus pneumoniae P1031 7682854 YP_002738303.1 CDS SPP_1158 NC_012467.1 1075799 1076800 R identified by match to protein family HMM PF00877; NLP/P60 family protein complement(1075799..1076800) Streptococcus pneumoniae P1031 7682071 YP_002738304.1 CDS SPP_1159 NC_012467.1 1076797 1078974 R conjugative transposon membrane protein complement(1076797..1078974) Streptococcus pneumoniae P1031 7680979 YP_002738305.1 CDS SPP_1160 NC_012467.1 1078977 1081424 R conjugative transposon protein complement(1078977..1081424) Streptococcus pneumoniae P1031 7680902 YP_002738306.1 CDS SPP_1161 NC_012467.1 1081408 1081914 R conjugative transposon membrane protein complement(1081408..1081914) Streptococcus pneumoniae P1031 7680817 YP_002738307.1 CDS SPP_1162 NC_012467.1 1081889 1082386 R identified by match to protein family HMM PF07275; conjugative transposon protein complement(1081889..1082386) Streptococcus pneumoniae P1031 7681432 YP_002738308.1 CDS SPP_1163 NC_012467.1 1082503 1082724 R hypothetical protein complement(1082503..1082724) Streptococcus pneumoniae P1031 7682397 YP_002738309.1 CDS SPP_1164 NC_012467.1 1082767 1083972 R identified by match to protein family HMM PF01381; match to protein family HMM PF02486; transcriptional regulator, Cro/CI family complement(1082767..1083972) Streptococcus pneumoniae P1031 7680896 YP_002738310.1 CDS SPP_1165 NC_012467.1 1084150 1085535 R identified by match to protein family HMM PF01580; ftsk/spoiiie family protein complement(1084150..1085535) Streptococcus pneumoniae P1031 7681330 YP_002738311.1 CDS SPP_1166 NC_012467.1 1085564 1085947 R identified by match to protein family HMM PF06125; conjugative transposon protein complement(1085564..1085947) Streptococcus pneumoniae P1031 7682086 YP_002738312.1 CDS SPP_1167 NC_012467.1 1085966 1086280 R identified by match to protein family HMM PF06125; conjugative transposon protein complement(1085966..1086280) Streptococcus pneumoniae P1031 7682634 YP_002738313.1 CDS SPP_1168 NC_012467.1 1086303 1086422 R hypothetical protein complement(1086303..1086422) Streptococcus pneumoniae P1031 7681589 YP_002738314.1 CDS SPP_1169 NC_012467.1 1086953 1087252 D hypothetical protein 1086953..1087252 Streptococcus pneumoniae P1031 7681749 YP_002738315.1 CDS SPP_1170 NC_012467.1 1087242 1087730 D hypothetical protein 1087242..1087730 Streptococcus pneumoniae P1031 7682197 YP_002738316.1 CDS SPP_1171 NC_012467.1 1087730 1089607 D identified by match to protein family HMM PF02534; TraG/TraD family protein 1087730..1089607 Streptococcus pneumoniae P1031 7682372 YP_002738317.1 CDS SPP_1172 NC_012467.1 1089628 1089870 D hypothetical protein 1089628..1089870 Streptococcus pneumoniae P1031 7681760 YP_002738318.1 CDS SPP_1173 NC_012467.1 1089887 1090741 D hypothetical protein 1089887..1090741 Streptococcus pneumoniae P1031 7681116 YP_002738319.1 CDS SPP_1174 NC_012467.1 1090795 1091154 D hypothetical protein 1090795..1091154 Streptococcus pneumoniae P1031 7681450 YP_002738320.1 CDS SPP_1175 NC_012467.1 1091147 1093462 D hypothetical protein 1091147..1093462 Streptococcus pneumoniae P1031 7680654 YP_002738321.1 CDS SPP_1176 NC_012467.1 1093474 1096287 D identified by match to protein family HMM PF01551; match to protein family HMM PF05257; M23 peptidase domain protein 1093474..1096287 Streptococcus pneumoniae P1031 7682754 YP_002738322.1 CDS SPP_1177 NC_012467.1 1096525 1097091 D hypothetical protein 1096525..1097091 Streptococcus pneumoniae P1031 7682130 YP_002738323.1 CDS SPP_1178 NC_012467.1 1097243 1097653 D Ig domain protein, group 2 domain protein 1097243..1097653 Streptococcus pneumoniae P1031 7681666 YP_002738324.1 CDS SPP_1179 NC_012467.1 1097701 1103931 D identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF02384; match to protein family HMM PF04851; SNF2 family protein 1097701..1103931 Streptococcus pneumoniae P1031 7682219 YP_002738325.1 CDS SPP_1180 NC_012467.1 1104006 1104290 D hypothetical protein 1104006..1104290 Streptococcus pneumoniae P1031 7681575 YP_002738326.1 CDS SPP_1181 NC_012467.1 1104304 1104600 D hypothetical protein 1104304..1104600 Streptococcus pneumoniae P1031 7680653 YP_002738327.1 CDS SPP_1182 NC_012467.1 1104614 1104811 R identified by glimmer; putative; hypothetical protein complement(1104614..1104811) Streptococcus pneumoniae P1031 7681368 YP_002738328.1 CDS SPP_1183 NC_012467.1 1104971 1105612 D hypothetical protein 1104971..1105612 Streptococcus pneumoniae P1031 7682006 YP_002738329.1 CDS SPP_1184 NC_012467.1 1105622 1106707 D DNA primase 1105622..1106707 Streptococcus pneumoniae P1031 7680787 YP_002738330.1 CDS SPP_1185 NC_012467.1 1106758 1106991 D hypothetical protein 1106758..1106991 Streptococcus pneumoniae P1031 7681688 YP_002738331.1 CDS SPP_1186 NC_012467.1 1106988 1107371 D methyl-accepting chemotaxis protein 1106988..1107371 Streptococcus pneumoniae P1031 7681624 YP_002738332.1 CDS SPP_1187 NC_012467.1 1107409 1107681 D ATPases with chaperone activity, ATP-binding subunit 1107409..1107681 Streptococcus pneumoniae P1031 7681736 YP_002738333.1 CDS SPP_1188 NC_012467.1 1107751 1108227 D identified by match to protein family HMM PF01381; helix-turn-helix domain protein 1107751..1108227 Streptococcus pneumoniae P1031 7682170 YP_002738334.1 CDS SPP_1189 NC_012467.1 1108227 1108997 D identified by match to protein family HMM PF06414; signal recognition particle GTPase 1108227..1108997 Streptococcus pneumoniae P1031 7682771 YP_002738335.1 CDS SPP_1190 NC_012467.1 1109225 1109908 D identified by match to protein family HMM PF00717; match to protein family HMM PF01381; transcriptional regulator 1109225..1109908 Streptococcus pneumoniae P1031 7681027 YP_002738336.1 CDS SPP_1191 NC_012467.1 1109911 1111326 D identified by match to protein family HMM PF00817; SOS responce UmuC protein 1109911..1111326 Streptococcus pneumoniae P1031 7681221 YP_002738337.1 CDS SPP_1192 NC_012467.1 1111326 1111688 D hypothetical protein 1111326..1111688 Streptococcus pneumoniae P1031 7680820 YP_002738338.1 CDS SPP_1193 NC_012467.1 1111678 1111968 D hypothetical protein 1111678..1111968 Streptococcus pneumoniae P1031 7681488 YP_002738339.1 CDS SPP_1194 NC_012467.1 1112264 1112620 D identified by glimmer; putative; hypothetical protein 1112264..1112620 Streptococcus pneumoniae P1031 7681010 YP_002738340.1 CDS SPP_1195 NC_012467.1 1112763 1112990 D identified by match to protein family HMM PF05713; putative mobilization protein (MobC) 1112763..1112990 Streptococcus pneumoniae P1031 7682231 YP_002738341.1 CDS SPP_1196 NC_012467.1 1112977 1114806 D identified by match to protein family HMM PF03432; relaxase 1112977..1114806 Streptococcus pneumoniae P1031 7681134 YP_002738342.1 CDS SPP_1197 NC_012467.1 1114910 1115134 D identified by match to protein family HMM PF01381; hypothetical protein 1114910..1115134 Streptococcus pneumoniae P1031 7681656 YP_002738343.1 CDS SPP_1198 NC_012467.1 1115722 1117230 D identified by match to protein family HMM PF00589; integrase 1115722..1117230 Streptococcus pneumoniae P1031 7682560 YP_002738344.1 CDS rbgA NC_012467.1 1117312 1118163 D essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1117312..1118163 Streptococcus pneumoniae P1031 7681498 YP_002738345.1 CDS rnhB NC_012467.1 1118150 1118929 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1118150..1118929 Streptococcus pneumoniae P1031 7682585 YP_002738346.1 CDS SPP_1201 NC_012467.1 1118945 1120495 D identified by match to protein family HMM PF00654; match to protein family HMM PF02080; voltage-gated chloride channel family protein 1118945..1120495 Streptococcus pneumoniae P1031 7682741 YP_002738347.1 CDS xerS NC_012467.1 1120989 1122059 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1120989..1122059 Streptococcus pneumoniae P1031 7681788 YP_002738348.1 CDS SPP_1203 NC_012467.1 1122132 1123121 R identified by match to protein family HMM PF03099; match to protein family HMM TIGR00545; lipoate protein ligase A complement(1122132..1123121) Streptococcus pneumoniae P1031 7682381 YP_002738349.1 CDS lpdA NC_012467.1 1123185 1124888 R identified by match to protein family HMM PF00070; match to protein family HMM PF00364; match to protein family HMM PF01134; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350; dihydrolipoyl dehydrogenase complement(1123185..1124888) Streptococcus pneumoniae P1031 7680861 YP_002738350.1 CDS SPP_1205 NC_012467.1 1124934 1125977 R unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain; dihydrolipoamide acetyltransferase complement(1124934..1125977) Streptococcus pneumoniae P1031 7682518 YP_002738351.1 CDS SPP_1206 NC_012467.1 1126195 1127187 R identified by match to protein family HMM PF02779; match to protein family HMM PF02780; pyruvate dehydrogenase E1 component subunit beta complement(1126195..1127187) Streptococcus pneumoniae P1031 7681447 YP_002738352.1 CDS SPP_1207 NC_012467.1 1127203 1128171 R identified by match to protein family HMM PF00676; pyruvate dehydrogenase E1 component subunit alpha complement(1127203..1128171) Streptococcus pneumoniae P1031 7682689 YP_002738353.1 CDS SPP_1208 NC_012467.1 1128325 1129686 R identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; mate efflux family protein complement(1128325..1129686) Streptococcus pneumoniae P1031 7681002 YP_002738354.1 CDS pyrC NC_012467.1 1129971 1131239 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1129971..1131239) Streptococcus pneumoniae P1031 7681740 YP_002738355.1 CDS SPP_1210 NC_012467.1 1131252 1131716 R identified by match to protein family HMM PF00293; mutator MutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase) complement(1131252..1131716) Streptococcus pneumoniae P1031 7681572 YP_002738356.1 CDS ung NC_012467.1 1131726 1132379 R Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase complement(1131726..1132379) Streptococcus pneumoniae P1031 7682358 YP_002738357.1 CDS SPP_1212 NC_012467.1 1132517 1133164 R hypothetical protein complement(1132517..1133164) Streptococcus pneumoniae P1031 7681366 YP_002738358.1 CDS SPP_1213 NC_012467.1 1133178 1133891 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; match to protein family HMM TIGR02254; HAD superfamily (subfamily IA) hydrolase complement(1133178..1133891) Streptococcus pneumoniae P1031 7682140 YP_002738359.1 CDS SPP_1214 NC_012467.1 1134144 1135490 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; identified by match to protein family HMM PF01609; Spn1 transposase complement(1134144..1135490) Streptococcus pneumoniae P1031 7682686 YP_002738360.1 CDS SPP_1217 NC_012467.1 1136859 1139393 R identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein B complement(1136859..1139393) Streptococcus pneumoniae P1031 7682242 YP_002738361.1 CDS SPP_1218 NC_012467.1 1139551 1142001 R identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein B complement(1139551..1142001) Streptococcus pneumoniae P1031 7681379 YP_002738362.1 CDS SPP_1220 NC_012467.1 1142122 1142259 D identified by glimmer; putative; hypothetical protein 1142122..1142259 Streptococcus pneumoniae P1031 7681441 YP_002738363.1 CDS ptsP NC_012467.1 1142256 1143989 R identified by match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR01417; phosphoenolpyruvate-protein phosphotransferase complement(1142256..1143989) Streptococcus pneumoniae P1031 7681600 YP_002738364.1 CDS SPP_1221 NC_012467.1 1143995 1144258 R identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; phosphocarrier protein HPr complement(1143995..1144258) Streptococcus pneumoniae P1031 7680642 YP_002738365.1 CDS SPP_1222 NC_012467.1 1144609 1144827 D identified by match to protein family HMM PF00462; match to protein family HMM TIGR02194; glutaredoxin 1144609..1144827 Streptococcus pneumoniae P1031 7681310 YP_002738366.1 CDS SPP_1223 NC_012467.1 1144908 1147067 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1144908..1147067 Streptococcus pneumoniae P1031 7681870 YP_002738367.1 CDS nrdF NC_012467.1 1147255 1148217 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1147255..1148217 Streptococcus pneumoniae P1031 7681637 YP_002738368.1 CDS SPP_1225 NC_012467.1 1148399 1149160 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; lactose phosphotransferase system repressor 1148399..1149160 Streptococcus pneumoniae P1031 7681349 YP_002738369.1 CDS SPP_1226 NC_012467.1 1149439 1149618 R identified by glimmer; putative; hypothetical protein complement(1149439..1149618) Streptococcus pneumoniae P1031 7681564 YP_002738370.1 CDS lacG2 NC_012467.1 1149741 1151147 R catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase complement(1149741..1151147) Streptococcus pneumoniae P1031 7680997 YP_002738371.1 CDS SPP_1228 NC_012467.1 1151362 1153053 R identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00394; match to protein family HMM TIGR00410; match to protein family HMM TIGR00853; PTS system, lactose-specific IIC component complement(1151362..1153053) Streptococcus pneumoniae P1031 7681094 YP_002738372.1 CDS SPP_1229 NC_012467.1 1153053 1153370 R identified by match to protein family HMM PF02255; match to protein family HMM TIGR00823; lactose-specific phosphotransferase enzyme iia component (pts system lactose-specific eiia component) (eiia-lac) (eiii-lac) complement(1153053..1153370) Streptococcus pneumoniae P1031 7680875 YP_002738373.1 CDS SPP_1230 NC_012467.1 1153406 1154242 R identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator LacT complement(1153406..1154242) Streptococcus pneumoniae P1031 7682401 YP_002738374.1 CDS lacD NC_012467.1 1154476 1155456 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase complement(1154476..1155456) Streptococcus pneumoniae P1031 7682622 YP_002738375.1 CDS lacC NC_012467.1 1155458 1156387 R catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase complement(1155458..1156387) Streptococcus pneumoniae P1031 7680790 YP_002738376.1 CDS lacB NC_012467.1 1156398 1156913 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB complement(1156398..1156913) Streptococcus pneumoniae P1031 7682869 YP_002738377.1 CDS lacA NC_012467.1 1156944 1157369 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA complement(1156944..1157369) Streptococcus pneumoniae P1031 7682635 YP_002738378.1 CDS SPP_1235 NC_012467.1 1157527 1157871 R identified by glimmer; putative; hypothetical protein complement(1157527..1157871) Streptococcus pneumoniae P1031 7681438 YP_002738379.1 CDS SPP_1236 NC_012467.1 1158040 1158429 R identified by match to protein family HMM PF01609; transposase (IS4 family) complement(1158040..1158429) Streptococcus pneumoniae P1031 7682225 YP_002738380.1 CDS SPP_1237 NC_012467.1 1158446 1158844 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element complement(1158446..1158844) Streptococcus pneumoniae P1031 7681396 YP_002738381.1 CDS SPP_1238 NC_012467.1 1158852 1159154 R PTS system, galactose-specific IIB component complement(1158852..1159154) Streptococcus pneumoniae P1031 7682753 YP_002738382.1 CDS SPP_1239 NC_012467.1 1159192 1159668 R identified by match to protein family HMM PF00359; phosphotransferase system sugar-specific EII component complement(1159192..1159668) Streptococcus pneumoniae P1031 7681538 YP_002738383.1 CDS SPP_1240 NC_012467.1 1159848 1160045 D chlorohydrolase 1159848..1160045 Streptococcus pneumoniae P1031 7681417 YP_002738384.1 CDS lepA NC_012467.1 1160126 1161949 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(1160126..1161949) Streptococcus pneumoniae P1031 7681275 YP_002738385.1 CDS SPP_1242 NC_012467.1 1162028 1162756 R identified by match to protein family HMM PF00149; serine/threonine protein phosphatase complement(1162028..1162756) Streptococcus pneumoniae P1031 7682452 YP_002738386.1 CDS recN NC_012467.1 1162758 1164425 R identified by match to protein family HMM PF02463; match to protein family HMM TIGR00634; DNA repair protein RecN complement(1162758..1164425) Streptococcus pneumoniae P1031 7681259 YP_002738387.1 CDS SPP_1244 NC_012467.1 1164432 1164863 R identified by match to protein family HMM PF01316; match to protein family HMM PF02863; transcriptional regulator of arginine metabolism expression complement(1164432..1164863) Streptococcus pneumoniae P1031 7682552 YP_002738388.1 CDS tylA NC_012467.1 1164856 1165671 R identified by match to protein family HMM PF01479; match to protein family HMM PF01728; match to protein family HMM TIGR00478; hemolysin A complement(1164856..1165671) Streptococcus pneumoniae P1031 7681752 YP_002738389.1 CDS SPP_1246 NC_012467.1 1165664 1166539 R identified by match to protein family HMM PF00348; geranyltranstransferase (Farnesyl-diphosphate synthase)(FPP synthase) complement(1165664..1166539) Streptococcus pneumoniae P1031 7682617 YP_002738390.1 CDS xseB NC_012467.1 1166536 1166748 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(1166536..1166748) Streptococcus pneumoniae P1031 7680641 YP_002738391.1 CDS xseA NC_012467.1 1166726 1168066 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(1166726..1168066) Streptococcus pneumoniae P1031 7681591 YP_002738392.1 CDS udk NC_012467.1 1168194 1168832 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(1168194..1168832) Streptococcus pneumoniae P1031 7680652 YP_002738393.1 CDS SPP_1250 NC_012467.1 1168940 1169242 R hypothetical protein complement(1168940..1169242) Streptococcus pneumoniae P1031 7681254 YP_002738394.1 CDS truB NC_012467.1 1169483 1170361 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(1169483..1170361) Streptococcus pneumoniae P1031 7681733 YP_002738395.1 CDS SPP_1252 NC_012467.1 1170371 1171645 R hypothetical protein complement(1170371..1171645) Streptococcus pneumoniae P1031 7682375 YP_002738396.1 CDS SPP_1255 NC_012467.1 1173148 1173945 R identified by match to protein family HMM PF01226; formate-nitrate transporter complement(1173148..1173945) Streptococcus pneumoniae P1031 7681510 YP_002738397.1 CDS SPP_1256 NC_012467.1 1174189 1174932 R identified by match to protein family HMM PF04203; match to protein family HMM TIGR01076; sortase complement(1174189..1174932) Streptococcus pneumoniae P1031 7682421 YP_002738398.1 CDS gyrA NC_012467.1 1174932 1177400 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(1174932..1177400) Streptococcus pneumoniae P1031 7681907 YP_002738399.1 CDS ldh NC_012467.1 1177594 1178580 D Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1177594..1178580 Streptococcus pneumoniae P1031 7682080 YP_002738400.1 CDS SPP_1259 NC_012467.1 1178870 1179613 R identified by match to protein family HMM PF00520; match to protein family HMM PF07885; potassium/ion channel protein complement(1178870..1179613) Streptococcus pneumoniae P1031 7680888 YP_002738401.1 CDS SPP_1260 NC_012467.1 1179660 1179914 R identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; cytotoxic translational repressor of toxin-antitoxin stability system complement(1179660..1179914) Streptococcus pneumoniae P1031 7681974 YP_002738402.1 CDS SPP_1261 NC_012467.1 1179916 1180158 R hypothetical protein complement(1179916..1180158) Streptococcus pneumoniae P1031 7681467 YP_002738403.1 CDS SPP_1262 NC_012467.1 1180249 1181058 R identified by match to protein family HMM PF00753; VicX protein complement(1180249..1181058) Streptococcus pneumoniae P1031 7681266 YP_002738404.1 CDS SPP_1263 NC_012467.1 1181060 1182409 R identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM TIGR00229; sensor protein YycG complement(1181060..1182409) Streptococcus pneumoniae P1031 7682789 YP_002738405.1 CDS SPP_1264 NC_012467.1 1182402 1183106 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; alkaline phosphatase synthesis transcriptional regulatory proteinphoP complement(1182402..1183106) Streptococcus pneumoniae P1031 7680874 YP_002738406.1 CDS mutY NC_012467.1 1183162 1184337 R identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01084; A/G-specific adenine glycosylase complement(1183162..1184337) Streptococcus pneumoniae P1031 7680969 YP_002738407.1 CDS fhs NC_012467.1 1184665 1186335 R catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase complement(1184665..1186335) Streptococcus pneumoniae P1031 7682324 YP_002738408.1 CDS coaB NC_012467.1 1186565 1187254 D identified by match to protein family HMM PF04127; match to protein family HMM TIGR02114; phosphopantothenate--cysteine ligase 1186565..1187254 Streptococcus pneumoniae P1031 7680655 YP_002738409.1 CDS coaC NC_012467.1 1187266 1187817 D decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 1187266..1187817 Streptococcus pneumoniae P1031 7682787 YP_002738410.1 CDS SPP_1270 NC_012467.1 1187801 1188364 D integral membrane protein 1187801..1188364 Streptococcus pneumoniae P1031 7681304 YP_002738411.1 CDS SPP_1271 NC_012467.1 1188646 1189173 D hypothetical protein 1188646..1189173 Streptococcus pneumoniae P1031 7682075 YP_002738412.1 CDS SPP_1273 NC_012467.1 1189185 1189700 D identified by match to protein family HMM PF02829; match to protein family HMM PF08279; transcriptional regulator, biotin repressor family 1189185..1189700 Streptococcus pneumoniae P1031 7681963 YP_002738413.1 CDS SPP_1272 NC_012467.1 1189697 1190164 R identified by match to protein family HMM PF00293; NTP pyrophosphohydrolase including oxidative damage repair enzymes complement(1189697..1190164) Streptococcus pneumoniae P1031 7680855 YP_002738414.1 CDS SPP_1274 NC_012467.1 1190238 1190726 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family complement(1190238..1190726) Streptococcus pneumoniae P1031 7681764 YP_002738415.1 CDS SPP_1275 NC_012467.1 1190692 1191255 R acetyltransferase, gnat family complement(1190692..1191255) Streptococcus pneumoniae P1031 7682062 YP_002738416.1 CDS uvrB NC_012467.1 1191265 1193253 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B complement(1191265..1193253) Streptococcus pneumoniae P1031 7681996 YP_002738417.1 CDS SPP_1277 NC_012467.1 1193330 1194283 R identified by match to protein family HMM PF02517; caax amino protease family complement(1193330..1194283) Streptococcus pneumoniae P1031 7681051 YP_002738418.1 CDS SPP_1278 NC_012467.1 1194456 1196621 D identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease/substrate-binding protein 1194456..1196621 Streptococcus pneumoniae P1031 7682639 YP_002738419.1 CDS SPP_1279 NC_012467.1 1196621 1197361 D identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 1196621..1197361 Streptococcus pneumoniae P1031 7682844 YP_002738420.1 CDS zwf NC_012467.1 1197510 1198997 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1197510..1198997 Streptococcus pneumoniae P1031 7682713 YP_002738421.1 CDS SPP_1281 NC_012467.1 1199041 1200330 R identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM TIGR00064; cell division protein FtsY complement(1199041..1200330) Streptococcus pneumoniae P1031 7681771 YP_002738422.1 CDS SPP_1282 NC_012467.1 1200334 1201152 R identified by match to protein family HMM PF00702; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1200334..1201152) Streptococcus pneumoniae P1031 7681875 YP_002738423.1 CDS SPP_1283 NC_012467.1 1201152 1201946 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1201152..1201946) Streptococcus pneumoniae P1031 7682037 YP_002738424.1 CDS smc NC_012467.1 1201943 1205482 R identified by match to protein family HMM PF02463; match to protein family HMM PF06470; match to protein family HMM TIGR02168; chromosome segregation protein SMC complement(1201943..1205482) Streptococcus pneumoniae P1031 7682864 YP_002738425.1 CDS rnc NC_012467.1 1205473 1206171 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(1205473..1206171) Streptococcus pneumoniae P1031 7682621 YP_002738426.1 CDS guaC NC_012467.1 1206489 1207475 R identified by match to protein family HMM PF00478; match to protein family HMM TIGR01306; guanosine 5'-monophosphate oxidoreductase complement(1206489..1207475) Streptococcus pneumoniae P1031 7680747 YP_002738427.1 CDS SPP_1288 NC_012467.1 1207650 1208966 R hypothetical protein complement(1207650..1208966) Streptococcus pneumoniae P1031 7682276 YP_002738428.1 CDS SPP_1289 NC_012467.1 1208953 1210866 R hypothetical protein complement(1208953..1210866) Streptococcus pneumoniae P1031 7680821 YP_002738429.1 CDS SPP_1293 NC_012467.1 1211815 1212174 R hypothetical protein complement(1211815..1212174) Streptococcus pneumoniae P1031 7681234 YP_002738430.1 CDS SPP_1294 NC_012467.1 1212178 1212447 R identified by match to protein family HMM PF06961; hypothetical protein complement(1212178..1212447) Streptococcus pneumoniae P1031 7681855 YP_002738431.1 CDS leuB NC_012467.1 1212444 1213481 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(1212444..1213481) Streptococcus pneumoniae P1031 7681922 YP_002738432.1 CDS SPP_1298 NC_012467.1 1214606 1215262 R identified by match to protein family HMM PF04237; hypothetical protein complement(1214606..1215262) Streptococcus pneumoniae P1031 7682786 YP_002738433.1 CDS SPP_1299 NC_012467.1 1215306 1215938 R identified by match to protein family HMM PF03932; copper homeostasis protein CutC complement(1215306..1215938) Streptococcus pneumoniae P1031 7681835 YP_002738434.1 CDS SPP_1300 NC_012467.1 1216031 1216390 R identified by match to protein family HMM PF04304; hypothetical protein complement(1216031..1216390) Streptococcus pneumoniae P1031 7681627 YP_002738435.1 CDS topA NC_012467.1 1216496 1218583 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(1216496..1218583) Streptococcus pneumoniae P1031 7682799 YP_002738436.1 CDS SPP_1302 NC_012467.1 1218750 1219793 R identified by match to protein family HMM PF04087; hypothetical protein complement(1218750..1219793) Streptococcus pneumoniae P1031 7681570 YP_002738437.1 CDS SPP_1303 NC_012467.1 1220371 1220493 D chlorohydrolase 1220371..1220493 Streptococcus pneumoniae P1031 7682653 YP_002738438.1 CDS dprA NC_012467.1 1220677 1221525 R identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732; DNA protecting protein DprA complement(1220677..1221525) Streptococcus pneumoniae P1031 7681982 YP_002738439.1 CDS SPP_1305 NC_012467.1 1221623 1222312 R identified by match to protein family HMM PF00483; LPS epitope expression regulatory protein complement(1221623..1222312) Streptococcus pneumoniae P1031 7682204 YP_002738440.1 CDS SPP_1306 NC_012467.1 1222324 1223202 R identified by match to protein family HMM PF00892; LPS epitope expression regulatory protein complement(1222324..1223202) Streptococcus pneumoniae P1031 7681250 YP_002738441.1 CDS SPP_1307 NC_012467.1 1223192 1224061 R identified by match to protein family HMM PF01633; match to protein family HMM PF01636; choline kinase complement(1223192..1224061) Streptococcus pneumoniae P1031 7682568 YP_002738442.1 CDS SPP_1308 NC_012467.1 1224078 1225100 R identified by match to protein family HMM PF08240; xylitol dehydrogenase complement(1224078..1225100) Streptococcus pneumoniae P1031 7680959 YP_002738443.1 CDS ispD NC_012467.1 1225105 1225812 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(1225105..1225812) Streptococcus pneumoniae P1031 7681427 YP_002738444.1 CDS SPP_1310 NC_012467.1 1226148 1227635 D identified by match to protein family HMM PF01943; match to protein family HMM PF03023; virulence factor mvin superfamily 1226148..1227635 Streptococcus pneumoniae P1031 7682720 YP_002738445.1 CDS SPP_1311 NC_012467.1 1227645 1228448 D required for phosphorylcholine incorporation in teichoic and lipoteichoic acids; identified by match to protein family HMM PF04991; phosphotransferase 1227645..1228448 Streptococcus pneumoniae P1031 7682502 YP_002738446.1 CDS SPP_1312 NC_012467.1 1228450 1229259 D identified by match to protein family HMM PF04991; LicD Protein 1228450..1229259 Streptococcus pneumoniae P1031 7681185 YP_002738447.1 CDS carB NC_012467.1 1229534 1232710 R four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit complement(1229534..1232710) Streptococcus pneumoniae P1031 7680676 YP_002738448.1 CDS carA NC_012467.1 1233023 1234102 R catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit complement(1233023..1234102) Streptococcus pneumoniae P1031 7682272 YP_002738449.1 CDS pyrB NC_012467.1 1234152 1235075 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit complement(1234152..1235075) Streptococcus pneumoniae P1031 7680852 YP_002738450.1 CDS SPP_1316 NC_012467.1 1235094 1235615 R regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase complement(1235094..1235615) Streptococcus pneumoniae P1031 7682451 YP_002738451.1 CDS nth NC_012467.1 1235826 1236455 R identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01083; endonuclease III complement(1235826..1236455) Streptococcus pneumoniae P1031 7680784 YP_002738452.1 CDS SPP_1318 NC_012467.1 1236455 1236997 R identified by match to protein family HMM PF02620; hypothetical protein complement(1236455..1236997) Streptococcus pneumoniae P1031 7681529 YP_002738453.1 CDS SPP_1319 NC_012467.1 1237119 1237307 D identified by glimmer; putative; hypothetical protein 1237119..1237307 Streptococcus pneumoniae P1031 7681421 YP_002738454.1 CDS SPP_1320 NC_012467.1 1237358 1237483 D identified by glimmer; putative; hypothetical protein 1237358..1237483 Streptococcus pneumoniae P1031 7682318 YP_002738455.1 CDS SPP_1321 NC_012467.1 1237722 1239281 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1237722..1239281 Streptococcus pneumoniae P1031 7682718 YP_002738456.1 CDS SPP_1322 NC_012467.1 1239325 1240224 R putative metalloprotease; heat shock protein HtpX complement(1239325..1240224) Streptococcus pneumoniae P1031 7682023 YP_002738457.1 CDS SPP_1323 NC_012467.1 1240226 1240786 R identified by match to protein family HMM PF04011; cytoplasmic membrane protein complement(1240226..1240786) Streptococcus pneumoniae P1031 7682157 YP_002738458.1 CDS gidB NC_012467.1 1240880 1241593 D glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1240880..1241593 Streptococcus pneumoniae P1031 7681953 YP_002738459.1 CDS SPP_1325 NC_012467.1 1241847 1243130 D identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; uracil permease (Uracil transporter) 1241847..1243130 Streptococcus pneumoniae P1031 7682469 YP_002738460.1 CDS ffh NC_012467.1 1243325 1244896 R identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959; signal recognition particle protein complement(1243325..1244896) Streptococcus pneumoniae P1031 7681692 YP_002738461.1 CDS SPP_1327 NC_012467.1 1244908 1245240 R identified by match to protein family HMM PF04297; match to protein family HMM PF04967; match to protein family HMM PF08281; putative DNA-binding protein complement(1244908..1245240) Streptococcus pneumoniae P1031 7682782 YP_002738462.1 CDS SPP_1328 NC_012467.1 1245331 1245696 R hypothetical protein complement(1245331..1245696) Streptococcus pneumoniae P1031 7681174 YP_002738463.1 CDS SPP_1329 NC_012467.1 1245780 1247084 D identified by match to protein family HMM PF01966; HD superfamily phosphohydrolase 1245780..1247084 Streptococcus pneumoniae P1031 7682569 YP_002738464.1 CDS SPP_1330 NC_012467.1 1247097 1247903 D identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; phosphatase YidA 1247097..1247903 Streptococcus pneumoniae P1031 7682726 YP_002738465.1 CDS SPP_1331 NC_012467.1 1247946 1248944 D identified by match to protein family HMM PF02037; SAP domain protein 1247946..1248944 Streptococcus pneumoniae P1031 7682180 YP_002738466.1 CDS rplS NC_012467.1 1249223 1249570 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(1249223..1249570) Streptococcus pneumoniae P1031 7680743 YP_002738467.1 CDS SPP_1334 NC_012467.1 1249689 1250018 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1249689..1250018) Streptococcus pneumoniae P1031 7681054 YP_002738468.1 CDS SPP_1335 NC_012467.1 1250012 1250386 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1250012..1250386) Streptococcus pneumoniae P1031 7682672 YP_002738469.1 CDS SPP_1336 NC_012467.1 1250383 1250649 R identified by match to protein family HMM PF01817; match to protein family HMM TIGR01805; hypothetical protein complement(1250383..1250649) Streptococcus pneumoniae P1031 7682329 YP_002738470.1 CDS SPP_1337 NC_012467.1 1250765 1251208 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(1250765..1251208) Streptococcus pneumoniae P1031 7681422 YP_002738471.1 CDS SPP_1338 NC_012467.1 1251312 1252247 D identified by match to protein family HMM PF01368; match to protein family HMM PF02272; DHH subfamily 1 protein 1251312..1252247 Streptococcus pneumoniae P1031 7681162 YP_002738472.1 CDS rpmE2 NC_012467.1 1252343 1252585 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 1252343..1252585 Streptococcus pneumoniae P1031 7681416 YP_002738473.1 CDS SPP_1340 NC_012467.1 1252642 1253187 R high-affinity Fe2+/Pb2+ permease complement(1252642..1253187) Streptococcus pneumoniae P1031 7681036 YP_002738474.1 CDS SPP_1343 NC_012467.1 1254250 1254654 R transposase complement(1254250..1254654) Streptococcus pneumoniae P1031 7681693 YP_002738475.1 CDS SPP_1344 NC_012467.1 1255198 1256544 D converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1255198..1256544 Streptococcus pneumoniae P1031 7682092 YP_002738476.1 CDS SPP_1345 NC_012467.1 1257040 1257210 R hypothetical protein complement(1257040..1257210) Streptococcus pneumoniae P1031 7682873 YP_002738477.1 CDS SPP_1346 NC_012467.1 1257223 1257864 R identified by match to protein family HMM PF00005; multidrug resistance protein 1 (ATP-binding cassettesub-family B member 1) (P-glycoprotein 1) (antigen) complement(1257223..1257864) Streptococcus pneumoniae P1031 7682627 YP_002738478.1 CDS SPP_1347 NC_012467.1 1258463 1259809 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; identified by match to protein family HMM PF01609; Spn1 transposase complement(1258463..1259809) Streptococcus pneumoniae P1031 7680936 YP_002738479.1 CDS SPP_1348 NC_012467.1 1259986 1260441 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1259986..1260441 Streptococcus pneumoniae P1031 7681687 YP_002738480.1 CDS SPP_1349 NC_012467.1 1260591 1260794 R glucokinase complement(1260591..1260794) Streptococcus pneumoniae P1031 7680627 YP_002738481.1 CDS SPP_1350 NC_012467.1 1260812 1261729 R identified by match to protein family HMM PF00701; N-acetylneuraminate lyase complement(1260812..1261729) Streptococcus pneumoniae P1031 7681926 YP_002738482.1 CDS cdd2 NC_012467.1 1261761 1262168 R identified by match to protein family HMM PF00383; match to protein family HMM TIGR01354; cytidine deaminase complement(1261761..1262168) Streptococcus pneumoniae P1031 7682494 YP_002738483.1 CDS pgpA NC_012467.1 1262456 1262944 R identified by match to protein family HMM PF04608; phosphatidylglycerophosphatase A complement(1262456..1262944) Streptococcus pneumoniae P1031 7682085 YP_002738484.1 CDS SPP_1353 NC_012467.1 1262949 1264358 R hypothetical protein complement(1262949..1264358) Streptococcus pneumoniae P1031 7681932 YP_002738485.1 CDS gsiA NC_012467.1 1264368 1266350 R identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; glutathione ABC transporter, ATP-binding protein complement(1264368..1266350) Streptococcus pneumoniae P1031 7682793 YP_002738486.1 CDS SPP_1355 NC_012467.1 1266363 1267214 R identified by match to protein family HMM PF00528; oligopeptide transport system permease protein AppC complement(1266363..1267214) Streptococcus pneumoniae P1031 7681301 YP_002738487.1 CDS SPP_1356 NC_012467.1 1267231 1268181 R identified by match to protein family HMM PF00528; oligopeptide transport system permease protein AppB complement(1267231..1268181) Streptococcus pneumoniae P1031 7681493 YP_002738488.1 CDS SPP_1357 NC_012467.1 1268290 1269918 R identified by match to protein family HMM PF00496; ABC transporter substrate-binding protein - oligopeptide transport complement(1268290..1269918) Streptococcus pneumoniae P1031 7682259 YP_002738489.1 CDS SPP_1358 NC_012467.1 1270000 1270923 R hypothetical protein complement(1270000..1270923) Streptococcus pneumoniae P1031 7682736 YP_002738490.1 CDS SPP_1359 NC_012467.1 1270947 1271645 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(1270947..1271645) Streptococcus pneumoniae P1031 7682017 YP_002738491.1 CDS SPP_1360 NC_012467.1 1271692 1271955 R mobile genetic element complement(1271692..1271955) Streptococcus pneumoniae P1031 7682606 YP_002738492.1 CDS SPP_1361 NC_012467.1 1272538 1272759 R hypothetical protein complement(1272538..1272759) Streptococcus pneumoniae P1031 7682762 YP_002738493.1 CDS SPP_1362 NC_012467.1 1273042 1273878 R identified by match to protein family HMM PF08843; hypothetical protein complement(1273042..1273878) Streptococcus pneumoniae P1031 7681746 YP_002738494.1 CDS SPP_1363 NC_012467.1 1273878 1274468 R hypothetical protein complement(1273878..1274468) Streptococcus pneumoniae P1031 7681990 YP_002738495.1 CDS SPP_1364 NC_012467.1 1274598 1275185 R identified by match to protein family HMM PF02517; caax amino protease family complement(1274598..1275185) Streptococcus pneumoniae P1031 7682030 YP_002738496.1 CDS SPP_1365 NC_012467.1 1275188 1275343 R identified by glimmer; putative; hypothetical protein complement(1275188..1275343) Streptococcus pneumoniae P1031 7681948 YP_002738497.1 CDS SPP_1366 NC_012467.1 1275434 1275814 R hypothetical protein complement(1275434..1275814) Streptococcus pneumoniae P1031 7681762 YP_002738498.1 CDS SPP_1367 NC_012467.1 1275807 1276256 R hypothetical protein complement(1275807..1276256) Streptococcus pneumoniae P1031 7681062 YP_002738499.1 CDS SPP_1372 NC_012467.1 1278505 1278678 R hypothetical protein complement(1278505..1278678) Streptococcus pneumoniae P1031 7681993 YP_002738500.1 CDS rplL NC_012467.1 1278865 1279233 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(1278865..1279233) Streptococcus pneumoniae P1031 7682588 YP_002738501.1 CDS rplJ NC_012467.1 1279309 1279809 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(1279309..1279809) Streptococcus pneumoniae P1031 7682387 YP_002738502.1 CDS SPP_1375 NC_012467.1 1280059 1281480 R identified by match to protein family HMM PF01979; match to protein family HMM PF07969; chlorohydrolase complement(1280059..1281480) Streptococcus pneumoniae P1031 7682181 YP_002738503.1 CDS SPP_1376 NC_012467.1 1281575 1283323 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease complement(1281575..1283323) Streptococcus pneumoniae P1031 7682819 YP_002738504.1 CDS SPP_1377 NC_012467.1 1283325 1285049 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease complement(1283325..1285049) Streptococcus pneumoniae P1031 7681796 YP_002738505.1 CDS SPP_1378 NC_012467.1 1285107 1286045 R identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; peptide methionine sulfoxide reductase MsrA/msrB complement(1285107..1286045) Streptococcus pneumoniae P1031 7680815 YP_002738506.1 CDS SPP_1379 NC_012467.1 1286074 1286415 R hypothetical protein complement(1286074..1286415) Streptococcus pneumoniae P1031 7681522 YP_002738507.1 CDS thrB NC_012467.1 1286431 1287300 R catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase complement(1286431..1287300) Streptococcus pneumoniae P1031 7681868 YP_002738508.1 CDS SPP_1381 NC_012467.1 1287302 1288588 R catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase complement(1287302..1288588) Streptococcus pneumoniae P1031 7682299 YP_002738509.1 CDS SPP_1382 NC_012467.1 1288739 1289476 R enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein complement(1288739..1289476) Streptococcus pneumoniae P1031 7681710 YP_002738510.1 CDS SPP_1383 NC_012467.1 1289676 1290710 R hypothetical protein complement(1289676..1290710) Streptococcus pneumoniae P1031 7680878 YP_002738511.1 CDS SPP_1384 NC_012467.1 1290739 1292172 R hypothetical protein complement(1290739..1292172) Streptococcus pneumoniae P1031 7680803 YP_002738512.1 CDS SPP_1385 NC_012467.1 1292188 1293174 R identified by match to protein family HMM PF00535; glycosyl transferase, family 2 complement(1292188..1293174) Streptococcus pneumoniae P1031 7682682 YP_002738513.1 CDS SPP_1386 NC_012467.1 1293176 1294276 R identified by match to protein family HMM PF00534; glycosyl transferase, group 1 family protein complement(1293176..1294276) Streptococcus pneumoniae P1031 7681079 YP_002738514.1 CDS SPP_1387 NC_012467.1 1294269 1295114 R identified by match to protein family HMM PF04991; licD3 protein complement(1294269..1295114) Streptococcus pneumoniae P1031 7682656 YP_002738515.1 CDS SPP_1388 NC_012467.1 1295393 1296667 R identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; transcriptional regulator, LytR family complement(1295393..1296667) Streptococcus pneumoniae P1031 7681612 YP_002738516.1 CDS SPP_1389 NC_012467.1 1296664 1297512 R catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase complement(1296664..1297512) Streptococcus pneumoniae P1031 7682363 YP_002738517.1 CDS aroK NC_012467.1 1297509 1297985 R identified by match to protein family HMM PF01202; shikimate kinase complement(1297509..1297985) Streptococcus pneumoniae P1031 7681369 YP_002738518.1 CDS aroA NC_012467.1 1297978 1299261 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(1297978..1299261) Streptococcus pneumoniae P1031 7681068 YP_002738519.1 CDS SPP_1392 NC_012467.1 1299353 1299691 R identified by match to protein family HMM PF06133; hypothetical protein complement(1299353..1299691) Streptococcus pneumoniae P1031 7682647 YP_002738520.1 CDS SPP_1393 NC_012467.1 1299702 1300805 R catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase complement(1299702..1300805) Streptococcus pneumoniae P1031 7682405 YP_002738521.1 CDS aroC NC_012467.1 1300815 1301981 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(1300815..1301981) Streptococcus pneumoniae P1031 7682224 YP_002738522.1 CDS aroB NC_012467.1 1301991 1303058 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(1301991..1303058) Streptococcus pneumoniae P1031 7681150 YP_002738523.1 CDS aroE NC_012467.1 1303077 1303931 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(1303077..1303931) Streptococcus pneumoniae P1031 7682862 YP_002738524.1 CDS aroD NC_012467.1 1303921 1304598 R catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase complement(1303921..1304598) Streptococcus pneumoniae P1031 7681873 YP_002738525.1 CDS SPP_1398 NC_012467.1 1304595 1305758 R methyltransferase complement(1304595..1305758) Streptococcus pneumoniae P1031 7681775 YP_002738526.1 CDS SPP_1399 NC_012467.1 1306445 1308079 R hypothetical protein complement(1306445..1308079) Streptococcus pneumoniae P1031 7681501 YP_002738527.1 CDS SPP_1400 NC_012467.1 1308060 1308809 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1308060..1308809) Streptococcus pneumoniae P1031 7680972 YP_002738528.1 CDS SPP_1401 NC_012467.1 1308988 1310442 D converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 1308988..1310442 Streptococcus pneumoniae P1031 7681483 YP_002738529.1 CDS alaS NC_012467.1 1310531 1313149 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(1310531..1313149) Streptococcus pneumoniae P1031 7680690 YP_002738530.1 CDS SPP_1403 NC_012467.1 1313171 1313656 R identified by match to protein family HMM PF04525; hypothetical protein complement(1313171..1313656) Streptococcus pneumoniae P1031 7682090 YP_002738531.1 CDS SPP_1404 NC_012467.1 1313931 1314170 R hypothetical protein complement(1313931..1314170) Streptococcus pneumoniae P1031 7681307 YP_002738532.1 CDS SPP_1405 NC_012467.1 1314431 1315501 R identified by match to protein family HMM PF01547; spermidine/putrescine ABC transporter, spermidine/putrescine-binding protein complement(1314431..1315501) Streptococcus pneumoniae P1031 7681989 YP_002738533.1 CDS SPP_1406 NC_012467.1 1315498 1316271 R identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease complement(1315498..1316271) Streptococcus pneumoniae P1031 7681574 YP_002738534.1 CDS SPP_1407 NC_012467.1 1316268 1317074 R identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease complement(1316268..1317074) Streptococcus pneumoniae P1031 7681588 YP_002738535.1 CDS SPP_1408 NC_012467.1 1317055 1318212 R identified by match to protein family HMM PF00005; match to protein family HMM PF08402; spermidine/putrescine import ATP-binding protein PotA complement(1317055..1318212) Streptococcus pneumoniae P1031 7680625 YP_002738536.1 CDS murB NC_012467.1 1318372 1319277 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(1318372..1319277) Streptococcus pneumoniae P1031 7681121 YP_002738537.1 CDS SPP_1410 NC_012467.1 1319389 1320141 R hypothetical protein complement(1319389..1320141) Streptococcus pneumoniae P1031 7682675 YP_002738538.1 CDS budA NC_012467.1 1320151 1320882 R identified by match to protein family HMM PF03306; match to protein family HMM TIGR01252; alpha-acetolactate decarboxylase complement(1320151..1320882) Streptococcus pneumoniae P1031 7682338 YP_002738539.1 CDS SPP_1412 NC_012467.1 1321024 1322295 D identified by match to protein family HMM PF00392; GntR family transcriptional regulator 1321024..1322295 Streptococcus pneumoniae P1031 7681491 YP_002738540.1 CDS SPP_1413 NC_012467.1 1322315 1323001 R identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein complement(1322315..1323001) Streptococcus pneumoniae P1031 7682015 YP_002738541.1 CDS phoU1 NC_012467.1 1323298 1323951 R identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU complement(1323298..1323951) Streptococcus pneumoniae P1031 7682746 YP_002738542.1 CDS pstB1 NC_012467.1 1323963 1324721 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1323963..1324721) Streptococcus pneumoniae P1031 7681599 YP_002738543.1 CDS pstB2 NC_012467.1 1324734 1325537 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1324734..1325537) Streptococcus pneumoniae P1031 7682743 YP_002738544.1 CDS pstA1 NC_012467.1 1325548 1326432 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease complement(1325548..1326432) Streptococcus pneumoniae P1031 7682051 YP_002738545.1 CDS pstC1 NC_012467.1 1326422 1327339 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease complement(1326422..1327339) Streptococcus pneumoniae P1031 7682512 YP_002738546.1 CDS SPP_1419 NC_012467.1 1327339 1328217 R identified by match to protein family HMM PF01547; match to protein family HMM TIGR02136; phosphate-binding protein PstS 1 (PBP 1) complement(1327339..1328217) Streptococcus pneumoniae P1031 7681935 YP_002738547.1 CDS SPP_1420 NC_012467.1 1328447 1328560 D hypothetical protein 1328447..1328560 Streptococcus pneumoniae P1031 7681689 YP_002738548.1 CDS SPP_1421 NC_012467.1 1328791 1330095 R identified by match to protein family HMM PF01189; NOL1/NOP2/sun family protein complement(1328791..1330095) Streptococcus pneumoniae P1031 7682133 YP_002738549.1 CDS SPP_1422 NC_012467.1 1330096 1330869 R identified by match to protein family HMM PF00459; inositol monophosphatase family protein complement(1330096..1330869) Streptococcus pneumoniae P1031 7681865 YP_002738550.1 CDS SPP_1423 NC_012467.1 1330859 1331137 R identified by match to protein family HMM PF05256; hypothetical protein complement(1330859..1331137) Streptococcus pneumoniae P1031 7681536 YP_002738551.1 CDS spxA NC_012467.1 1331137 1331538 R the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx complement(1331137..1331538) Streptococcus pneumoniae P1031 7681169 YP_002738552.1 CDS SPP_1425 NC_012467.1 1331748 1332365 R identified by match to protein family HMM PF07314; match to protein family HMM TIGR01906; integral membrane protein complement(1331748..1332365) Streptococcus pneumoniae P1031 7681823 YP_002738553.1 CDS SPP_1426 NC_012467.1 1332355 1333128 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01457; match to protein family HMM TIGR01460; HAD-superfamily subfamily IIA hydrolase complement(1332355..1333128) Streptococcus pneumoniae P1031 7682872 YP_002738554.1 CDS SPP_1427 NC_012467.1 1333139 1333876 R identified by match to protein family HMM PF01643; acyl-ACP thioesterase complement(1333139..1333876) Streptococcus pneumoniae P1031 7680867 YP_002738555.1 CDS SPP_1428 NC_012467.1 1333881 1335011 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(1333881..1335011) Streptococcus pneumoniae P1031 7681336 YP_002738556.1 CDS SPP_1429 NC_012467.1 1335095 1335484 R hypothetical protein complement(1335095..1335484) Streptococcus pneumoniae P1031 7681329 YP_002738557.1 CDS SPP_1430 NC_012467.1 1335500 1335883 R identified by match to protein family HMM PF06103; hypothetical protein complement(1335500..1335883) Streptococcus pneumoniae P1031 7682120 YP_002738558.1 CDS lgt NC_012467.1 1335884 1336672 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(1335884..1336672) Streptococcus pneumoniae P1031 7681708 YP_002738559.1 CDS hprK NC_012467.1 1336665 1337600 R catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase complement(1336665..1337600) Streptococcus pneumoniae P1031 7682815 YP_002738560.1 CDS rpsU NC_012467.1 1337730 1337906 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(1337730..1337906) Streptococcus pneumoniae P1031 7682044 YP_002738561.1 CDS SPP_1434 NC_012467.1 1338046 1338753 R identified by match to protein family HMM PF01182; glucosamine-6-phosphate deaminase (glucosamine-6-phosphate isomerase) (gnpda) (glcn6p deaminase) complement(1338046..1338753) Streptococcus pneumoniae P1031 7681114 YP_002738562.1 CDS queA NC_012467.1 1338904 1339932 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 1338904..1339932 Streptococcus pneumoniae P1031 7681783 YP_002738563.1 CDS SPP_1436 NC_012467.1 1340593 1340982 R identified by match to protein family HMM PF01473; choline binding protein complement(1340593..1340982) Streptococcus pneumoniae P1031 7682323 YP_002738564.1 CDS SPP_1437 NC_012467.1 1342442 1342993 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family complement(1342442..1342993) Streptococcus pneumoniae P1031 7682852 YP_002738565.1 CDS nadE NC_012467.1 1343343 1344167 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1343343..1344167) Streptococcus pneumoniae P1031 7682648 YP_002738566.1 CDS pncB NC_012467.1 1344164 1345624 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1344164..1345624) Streptococcus pneumoniae P1031 7681341 YP_002738567.1 CDS SPP_1440 NC_012467.1 1345740 1346228 R hypothetical protein complement(1345740..1346228) Streptococcus pneumoniae P1031 7680880 YP_002738568.1 CDS SPP_1441 NC_012467.1 1346218 1346427 R identified by match to protein family HMM PF01381; hypothetical protein complement(1346218..1346427) Streptococcus pneumoniae P1031 7682344 YP_002738569.1 CDS SPP_1442 NC_012467.1 1346892 1347293 R identified by glimmer; putative; hypothetical protein complement(1346892..1347293) Streptococcus pneumoniae P1031 7682673 YP_002738570.1 CDS SPP_1445 NC_012467.1 1348343 1348456 R identified by glimmer; putative; hypothetical protein complement(1348343..1348456) Streptococcus pneumoniae P1031 7682099 YP_002738571.1 CDS SPP_1448 NC_012467.1 1349501 1349812 R identified by glimmer; putative; hypothetical protein complement(1349501..1349812) Streptococcus pneumoniae P1031 7681655 YP_002738572.1 CDS SPP_1449 NC_012467.1 1349827 1351113 R identified by match to protein family HMM PF01136; peptidase, U32 family protein complement(1349827..1351113) Streptococcus pneumoniae P1031 7680853 YP_002738573.1 CDS SPP_1452 NC_012467.1 1352286 1353476 D identified by match to protein family HMM PF01555; DNA modification methyltransferase M.XbaI 1352286..1353476 Streptococcus pneumoniae P1031 7680651 YP_002738574.1 CDS SPP_1453 NC_012467.1 1353723 1353869 D hypothetical protein 1353723..1353869 Streptococcus pneumoniae P1031 7681297 YP_002738575.1 CDS SPP_1454 NC_012467.1 1353991 1354983 R identified by match to protein family HMM PF00165; AraC family transcriptional regulator complement(1353991..1354983) Streptococcus pneumoniae P1031 7682081 YP_002738576.1 CDS SPP_1455 NC_012467.1 1355143 1356897 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein/permease 1355143..1356897 Streptococcus pneumoniae P1031 7682468 YP_002738577.1 CDS SPP_1456 NC_012467.1 1356881 1358602 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1356881..1358602 Streptococcus pneumoniae P1031 7681966 YP_002738578.1 CDS SPP_1457 NC_012467.1 1358613 1359197 D identified by match to protein family HMM TIGR02185; hypothetical protein 1358613..1359197 Streptococcus pneumoniae P1031 7681414 YP_002738579.1 CDS SPP_1458 NC_012467.1 1359197 1359892 D identified by match to protein family HMM PF02361; cobalt transport protein 1359197..1359892 Streptococcus pneumoniae P1031 7680636 YP_002738580.1 CDS SPP_1459 NC_012467.1 1359880 1361244 D identified by match to protein family HMM PF00005; cobalt ABC transporter, ATPase component, CbiO 1359880..1361244 Streptococcus pneumoniae P1031 7680851 YP_002738581.1 CDS SPP_1461 NC_012467.1 1362544 1362855 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; transposase complement(1362544..1362855) Streptococcus pneumoniae P1031 7682398 YP_002738582.1 CDS SPP_1462 NC_012467.1 1362874 1363341 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; transposase complement(1362874..1363341) Streptococcus pneumoniae P1031 7681884 YP_002738583.1 CDS SPP_1463 NC_012467.1 1363244 1363438 R identified by glimmer; putative; hypothetical protein complement(1363244..1363438) Streptococcus pneumoniae P1031 7681698 YP_002738584.1 CDS SPP_1464 NC_012467.1 1363722 1363958 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; identified by match to protein family HMM PF05717; transposase complement(1363722..1363958) Streptococcus pneumoniae P1031 7682289 YP_002738585.1 CDS SPP_1465 NC_012467.1 1363939 1364124 R hypothetical protein complement(1363939..1364124) Streptococcus pneumoniae P1031 7681324 YP_002738586.1 CDS guaA NC_012467.1 1364428 1365990 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(1364428..1365990) Streptococcus pneumoniae P1031 7681801 YP_002738587.1 CDS SPP_1467 NC_012467.1 1366132 1366830 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 1366132..1366830 Streptococcus pneumoniae P1031 7680892 YP_002738588.1 CDS SPP_1468 NC_012467.1 1366873 1367769 R identified by match to protein family HMM PF00892; membrane protein complement(1366873..1367769) Streptococcus pneumoniae P1031 7680977 YP_002738589.1 CDS SPP_1469 NC_012467.1 1367778 1368713 R identified by match to protein family HMM PF00144; beta-lactamase complement(1367778..1368713) Streptococcus pneumoniae P1031 7681489 YP_002738590.1 CDS SPP_1470 NC_012467.1 1368710 1369435 R CppA protein complement(1368710..1369435) Streptococcus pneumoniae P1031 7681130 YP_002738591.1 CDS SPP_1471 NC_012467.1 1369519 1370154 R identified by match to protein family HMM PF00657; hypothetical protein complement(1369519..1370154) Streptococcus pneumoniae P1031 7682763 YP_002738592.1 CDS SPP_1472 NC_012467.1 1370156 1370983 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; hypothetical protein complement(1370156..1370983) Streptococcus pneumoniae P1031 7681881 YP_002738593.1 CDS def NC_012467.1 1372503 1373114 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1372503..1373114 Streptococcus pneumoniae P1031 7680804 YP_002738594.1 CDS SPP_1477 NC_012467.1 1373159 1373887 D identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; RNA methyltransferase, TrmH family, group 3 1373159..1373887 Streptococcus pneumoniae P1031 7681084 YP_002738595.1 CDS trxB NC_012467.1 1373926 1374837 R identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01292; thioredoxin-disulfide reductase complement(1373926..1374837) Streptococcus pneumoniae P1031 7682561 YP_002738596.1 CDS SPP_1479 NC_012467.1 1374903 1375127 R hypothetical protein complement(1374903..1375127) Streptococcus pneumoniae P1031 7682464 YP_002738597.1 CDS SPP_1480 NC_012467.1 1375205 1375948 R identified by match to protein family HMM PF00005; L-cystine import ATP-binding protein TcyN complement(1375205..1375948) Streptococcus pneumoniae P1031 7681936 YP_002738598.1 CDS SPP_1481 NC_012467.1 1375948 1376748 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; aspartate/glutamate ABC transporter permease complement(1375948..1376748) Streptococcus pneumoniae P1031 7681293 YP_002738599.1 CDS SPP_1482 NC_012467.1 1376906 1377262 R identified by match to protein family HMM PF03960; match to protein family HMM TIGR01617; arsenate reductase complement(1376906..1377262) Streptococcus pneumoniae P1031 7681240 YP_002738600.1 CDS SPP_1483 NC_012467.1 1377275 1377787 R identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589; O6-methylguanine-DNA methyltransferase complement(1377275..1377787) Streptococcus pneumoniae P1031 7681347 YP_002738601.1 CDS SPP_1484 NC_012467.1 1377787 1378281 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family complement(1377787..1378281) Streptococcus pneumoniae P1031 7681882 YP_002738602.1 CDS SPP_1485 NC_012467.1 1378416 1378862 D identified by match to protein family HMM PF08876; hypothetical protein 1378416..1378862 Streptococcus pneumoniae P1031 7682457 YP_002738603.1 CDS SPP_1486 NC_012467.1 1378859 1379506 D identified by match to protein family HMM PF03006; match to protein family HMM TIGR01065; hemolysin-3 (Hemolysin III) (Hly-III) 1378859..1379506 Streptococcus pneumoniae P1031 7681921 YP_002738604.1 CDS SPP_1487 NC_012467.1 1379527 1380108 R with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT complement(1379527..1380108) Streptococcus pneumoniae P1031 7682107 YP_002738605.1 CDS SPP_1488 NC_012467.1 1380109 1380984 R with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS complement(1380109..1380984) Streptococcus pneumoniae P1031 7680678 YP_002738606.1 CDS SPP_1489 NC_012467.1 1381136 1382515 R identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; NADH oxidase (noxase) complement(1381136..1382515) Streptococcus pneumoniae P1031 7681949 YP_002738607.1 CDS SPP_1490 NC_012467.1 1382657 1382812 D hypothetical protein 1382657..1382812 Streptococcus pneumoniae P1031 7682474 YP_002738608.1 CDS SPP_1491 NC_012467.1 1382809 1383732 D identified by match to protein family HMM PF02424; thiamine biosynthesis lipoprotein 1382809..1383732 Streptococcus pneumoniae P1031 7682851 YP_002738609.1 CDS SPP_1492 NC_012467.1 1383792 1384397 D identified by match to protein family HMM PF03358; NADPH-dependent fmn reductase domain protein 1383792..1384397 Streptococcus pneumoniae P1031 7682667 YP_002738610.1 CDS SPP_1493 NC_012467.1 1384416 1385660 D identified by match to protein family HMM PF03358; NADPH-dependent fmn reductase domain protein 1384416..1385660 Streptococcus pneumoniae P1031 7681145 YP_002738611.1 CDS SPP_1494 NC_012467.1 1385883 1386140 R identified by match to protein family HMM PF05979; hypothetical protein complement(1385883..1386140) Streptococcus pneumoniae P1031 7681702 YP_002738612.1 CDS glyS NC_012467.1 1386182 1388218 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(1386182..1388218) Streptococcus pneumoniae P1031 7681626 YP_002738613.1 CDS glyQ NC_012467.1 1388478 1389395 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(1388478..1389395) Streptococcus pneumoniae P1031 7681827 YP_002738614.1 CDS SPP_1497 NC_012467.1 1389764 1390090 R identified by glimmer; putative; hypothetical protein complement(1389764..1390090) Streptococcus pneumoniae P1031 7681436 YP_002738615.1 CDS SPP_1498 NC_012467.1 1390057 1390341 R identified by glimmer; putative; hypothetical protein complement(1390057..1390341) Streptococcus pneumoniae P1031 7681077 YP_002738616.1 CDS SPP_1499 NC_012467.1 1390614 1391456 R identified by match to protein family HMM PF00248; 2,5-diketo-d-gluconic acid reductase a (2,5-dkgreductase a) (2,5-dkgr a) (25dkgr-a) (akr5c) complement(1390614..1391456) Streptococcus pneumoniae P1031 7682104 YP_002738617.1 CDS SPP_1500 NC_012467.1 1391570 1392907 R identified by match to protein family HMM PF01522; peptidoglycan GlcNAc deacetylase complement(1391570..1392907) Streptococcus pneumoniae P1031 7680695 YP_002738618.1 CDS SPP_1501 NC_012467.1 1393196 1393573 R hypothetical protein complement(1393196..1393573) Streptococcus pneumoniae P1031 7682480 YP_002738619.1 CDS SPP_1502 NC_012467.1 1393788 1394765 D identified by match to protein family HMM PF01118; match to protein family HMM PF01408; oxidoreductase 1393788..1394765 Streptococcus pneumoniae P1031 7681952 YP_002738620.1 CDS SPP_1503 NC_012467.1 1394762 1395844 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; DEAD RNA helicase 1394762..1395844 Streptococcus pneumoniae P1031 7682427 YP_002738621.1 CDS SPP_1504 NC_012467.1 1396003 1396560 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(1396003..1396560) Streptococcus pneumoniae P1031 7682346 YP_002738622.1 CDS SPP_1505 NC_012467.1 1396448 1396714 R transposase complement(1396448..1396714) Streptococcus pneumoniae P1031 7681356 YP_002738623.1 CDS SPP_1506 NC_012467.1 1396835 1396954 R identified by glimmer; putative; hypothetical protein complement(1396835..1396954) Streptococcus pneumoniae P1031 7681053 YP_002738624.1 CDS tuf NC_012467.1 1397338 1398534 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(1397338..1398534) Streptococcus pneumoniae P1031 7682704 YP_002738625.1 CDS SPP_1508 NC_012467.1 1398877 1398999 R hypothetical protein complement(1398877..1398999) Streptococcus pneumoniae P1031 7682868 YP_002738626.1 CDS SPP_1509 NC_012467.1 1399410 1400279 R identified by match to protein family HMM PF00230; glycerol facilitator-aquaporin gla (Aquaglyceroporin)(Glyceroaquaporin) complement(1399410..1400279) Streptococcus pneumoniae P1031 7682557 YP_002738627.1 CDS SPP_1510 NC_012467.1 1400304 1400426 R identified by glimmer; putative; hypothetical protein complement(1400304..1400426) Streptococcus pneumoniae P1031 7681091 YP_002738628.1 CDS SPP_1511 NC_012467.1 1400502 1401182 R identified by match to protein family HMM PF00746; match to protein family HMM PF06458; match to protein family HMM TIGR01167; MucBP domain family complement(1400502..1401182) Streptococcus pneumoniae P1031 7682193 YP_002738629.1 CDS SPP_1512 NC_012467.1 1401140 1402054 R hypothetical protein complement(1401140..1402054) Streptococcus pneumoniae P1031 7682108 YP_002738630.1 CDS SPP_1513 NC_012467.1 1402182 1402379 R identified by glimmer; putative; hypothetical protein complement(1402182..1402379) Streptococcus pneumoniae P1031 7680662 YP_002738631.1 CDS SPP_1514 NC_012467.1 1402357 1402611 R hypothetical protein complement(1402357..1402611) Streptococcus pneumoniae P1031 7681986 YP_002738632.1 CDS SPP_1515 NC_012467.1 1402969 1403502 R transposase complement(1402969..1403502) Streptococcus pneumoniae P1031 7681904 YP_002738633.1 CDS SPP_1516 NC_012467.1 1403489 1403623 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(1403489..1403623) Streptococcus pneumoniae P1031 7681030 YP_002738634.1 CDS SPP_1517 NC_012467.1 1403671 1403814 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(1403671..1403814) Streptococcus pneumoniae P1031 7682057 YP_002738635.1 CDS SPP_1518 NC_012467.1 1404048 1405766 D identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880; phosphomannomutase 1404048..1405766 Streptococcus pneumoniae P1031 7682217 YP_002738636.1 CDS SPP_1519 NC_012467.1 1405877 1406224 D identified by match to protein family HMM TIGR01295; bacterocin transport accessory protein 1405877..1406224 Streptococcus pneumoniae P1031 7682296 YP_002738637.1 CDS SPP_1520 NC_012467.1 1406502 1407338 R identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein - glutamine transport complement(1406502..1407338) Streptococcus pneumoniae P1031 7682178 YP_002738638.1 CDS SPP_1521 NC_012467.1 1407351 1407980 R identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ complement(1407351..1407980) Streptococcus pneumoniae P1031 7681098 YP_002738639.1 CDS SPP_1522 NC_012467.1 1407990 1408631 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease complement(1407990..1408631) Streptococcus pneumoniae P1031 7682171 YP_002738640.1 CDS SPP_1523 NC_012467.1 1408777 1410006 R identified by match to protein family HMM PF00515; match to protein family HMM PF07719; TPR domain protein complement(1408777..1410006) Streptococcus pneumoniae P1031 7681153 YP_002738641.1 CDS SPP_1524 NC_012467.1 1409996 1411162 R identified by match to protein family HMM PF01594; transport protein complement(1409996..1411162) Streptococcus pneumoniae P1031 7682716 YP_002738642.1 CDS SPP_1525 NC_012467.1 1411306 1412319 D 3-carboxymuconate cyclase 1411306..1412319 Streptococcus pneumoniae P1031 7680885 YP_002738643.1 CDS atpC NC_012467.1 1412364 1412783 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon complement(1412364..1412783) Streptococcus pneumoniae P1031 7680797 YP_002738644.1 CDS atpD NC_012467.1 1412794 1414200 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(1412794..1414200) Streptococcus pneumoniae P1031 7681913 YP_002738645.1 CDS atpG NC_012467.1 1414286 1415164 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma complement(1414286..1415164) Streptococcus pneumoniae P1031 7682810 YP_002738646.1 CDS atpA NC_012467.1 1415180 1416685 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(1415180..1416685) Streptococcus pneumoniae P1031 7681439 YP_002738647.1 CDS atpH NC_012467.1 1416700 1417236 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(1416700..1417236) Streptococcus pneumoniae P1031 7682156 YP_002738648.1 CDS atpF NC_012467.1 1417236 1417730 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B complement(1417236..1417730) Streptococcus pneumoniae P1031 7681480 YP_002738649.1 CDS atpB NC_012467.1 1417744 1418460 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(1417744..1418460) Streptococcus pneumoniae P1031 7681124 YP_002738650.1 CDS SPP_1533 NC_012467.1 1418495 1418695 R produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(1418495..1418695) Streptococcus pneumoniae P1031 7682220 YP_002738651.1 CDS SPP_1534 NC_012467.1 1418770 1419777 R identified by match to protein family HMM PF00665; transposase complement(1418770..1419777) Streptococcus pneumoniae P1031 7682266 YP_002738652.1 CDS SPP_1536 NC_012467.1 1420741 1421109 D chlorohydrolase 1420741..1421109 Streptococcus pneumoniae P1031 7682454 YP_002738653.1 CDS greA NC_012467.1 1421166 1421648 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1421166..1421648) Streptococcus pneumoniae P1031 7681526 YP_002738654.1 CDS SPP_1538 NC_012467.1 1421719 1423374 R identified by match to protein family HMM PF02618; match to protein family HMM TIGR00247; aminodeoxychorismate lyase complement(1421719..1423374) Streptococcus pneumoniae P1031 7682654 YP_002738655.1 CDS SPP_1539 NC_012467.1 1423455 1423949 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family complement(1423455..1423949) Streptococcus pneumoniae P1031 7682201 YP_002738656.1 CDS SPP_1540 NC_012467.1 1423946 1424410 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family complement(1423946..1424410) Streptococcus pneumoniae P1031 7682443 YP_002738657.1 CDS murC NC_012467.1 1424420 1425754 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(1424420..1425754) Streptococcus pneumoniae P1031 7680661 YP_002738658.1 CDS SPP_1542 NC_012467.1 1425765 1426382 R hypothetical protein complement(1425765..1426382) Streptococcus pneumoniae P1031 7682749 YP_002738659.1 CDS SPP_1543 NC_012467.1 1426430 1429528 R identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434; match to protein family HMM PF08455; Snf2 family protein complement(1426430..1429528) Streptococcus pneumoniae P1031 7682417 YP_002738660.1 CDS SPP_1544 NC_012467.1 1429621 1430787 R identified by match to protein family HMM PF00155; putative aminotransferase B complement(1429621..1430787) Streptococcus pneumoniae P1031 7681187 YP_002738661.1 CDS SPP_1545 NC_012467.1 1430795 1431889 R catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase complement(1430795..1431889) Streptococcus pneumoniae P1031 7682551 YP_002738662.1 CDS SPP_1546 NC_012467.1 1432047 1432769 R identified by match to protein family HMM PF00005; ABC transporter complement(1432047..1432769) Streptococcus pneumoniae P1031 7681691 YP_002738663.1 CDS SPP_1547 NC_012467.1 1432929 1434275 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; identified by match to protein family HMM PF01609; Spn1 transposase 1432929..1434275 Streptococcus pneumoniae P1031 7682805 YP_002738664.1 CDS SPP_1550 NC_012467.1 1435609 1437567 R identified by match to protein family HMM PF00496; oligopeptide binding lipoprotein complement(1435609..1437567) Streptococcus pneumoniae P1031 7681370 YP_002738665.1 CDS SPP_1551 NC_012467.1 1437770 1439407 R identified by match to protein family HMM PF01943; match to protein family HMM PF03023; polysaccharide transporter complement(1437770..1439407) Streptococcus pneumoniae P1031 7680927 YP_002738666.1 CDS SPP_1552 NC_012467.1 1439498 1440943 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1439498..1440943 Streptococcus pneumoniae P1031 7682256 YP_002738667.1 CDS SPP_1553 NC_012467.1 1440989 1441183 R identified by match to protein family HMM PF05532; hypothetical protein complement(1440989..1441183) Streptococcus pneumoniae P1031 7681997 YP_002738668.1 CDS SPP_1554 NC_012467.1 1441284 1441568 R identified by glimmer; putative; hypothetical protein complement(1441284..1441568) Streptococcus pneumoniae P1031 7681182 YP_002738669.1 CDS SPP_1555 NC_012467.1 1441565 1441879 R identified by glimmer; putative; hypothetical protein complement(1441565..1441879) Streptococcus pneumoniae P1031 7681681 YP_002738670.1 CDS SPP_1556 NC_012467.1 1441916 1442428 R hypothetical protein complement(1441916..1442428) Streptococcus pneumoniae P1031 7681424 YP_002738671.1 CDS SPP_1557 NC_012467.1 1442514 1443449 R catalyzes the hydrolysis of pyrophosphate to phosphate; putative manganese-dependent inorganic pyrophosphatase complement(1442514..1443449) Streptococcus pneumoniae P1031 7681850 YP_002738672.1 CDS SPP_1558 NC_012467.1 1443520 1443819 R identified by match to protein family HMM PF01541; hypothetical protein complement(1443520..1443819) Streptococcus pneumoniae P1031 7681734 YP_002738673.1 CDS SPP_1559 NC_012467.1 1443809 1444558 R identified by match to protein family HMM PF05175; methyltransferase complement(1443809..1444558) Streptococcus pneumoniae P1031 7682117 YP_002738674.1 CDS SPP_1560 NC_012467.1 1444612 1444998 R identified by match to protein family HMM PF00575; hypothetical protein complement(1444612..1444998) Streptococcus pneumoniae P1031 7681784 YP_002738675.1 CDS SPP_1561 NC_012467.1 1444973 1446373 R identified by match to protein family HMM PF00160; match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein/peptidyl-prolyl cis-trans isomerase, cyclophilin type complement(1444973..1446373) Streptococcus pneumoniae P1031 7682374 YP_002738676.1 CDS rpsR NC_012467.1 1446668 1446907 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(1446668..1446907) Streptococcus pneumoniae P1031 7681928 YP_002738677.1 CDS SPP_1563 NC_012467.1 1446939 1447409 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1446939..1447409) Streptococcus pneumoniae P1031 7681431 YP_002738678.1 CDS rpsF NC_012467.1 1447421 1447711 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(1447421..1447711) Streptococcus pneumoniae P1031 7681560 YP_002738679.1 CDS asnC NC_012467.1 1447864 1449207 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(1447864..1449207) Streptococcus pneumoniae P1031 7682711 YP_002738680.1 CDS SPP_1566 NC_012467.1 1449226 1449591 R identified by match to protein family HMM PF00903; glyoxalase family protein complement(1449226..1449591) Streptococcus pneumoniae P1031 7682795 YP_002738681.1 CDS SPP_1567 NC_012467.1 1449584 1450771 R catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase complement(1449584..1450771) Streptococcus pneumoniae P1031 7681854 YP_002738682.1 CDS SPP_1568 NC_012467.1 1450768 1451256 R identified by match to protein family HMM PF03413; peptidase propeptide and ypeb domain protein complement(1450768..1451256) Streptococcus pneumoniae P1031 7681261 YP_002738683.1 CDS SPP_1569 NC_012467.1 1451323 1451439 R identified by glimmer; putative; hypothetical protein complement(1451323..1451439) Streptococcus pneumoniae P1031 7682612 YP_002738684.1 CDS SPP_1570 NC_012467.1 1451577 1452125 D identified by match to protein family HMM PF02525; match to protein family HMM PF03358; oxidoreductase 1451577..1452125 Streptococcus pneumoniae P1031 7681816 YP_002738685.1 CDS SPP_1571 NC_012467.1 1452402 1453130 R identified by match to protein family HMM PF03883; hypothetical protein complement(1452402..1453130) Streptococcus pneumoniae P1031 7682740 YP_002738686.1 CDS SPP_1572 NC_012467.1 1453209 1453373 R hypothetical protein complement(1453209..1453373) Streptococcus pneumoniae P1031 7681103 YP_002738687.1 CDS SPP_1573 NC_012467.1 1453440 1455035 R hypothetical protein complement(1453440..1455035) Streptococcus pneumoniae P1031 7682194 YP_002738688.1 CDS def2 NC_012467.1 1455047 1455457 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(1455047..1455457) Streptococcus pneumoniae P1031 7682190 YP_002738689.1 CDS SPP_1575 NC_012467.1 1455573 1456364 R YghU; B2989; one of eight putative glutathione transferase proteins from E. coli; putative glutathione S-transferase YghU complement(1455573..1456364) Streptococcus pneumoniae P1031 7682811 YP_002738690.1 CDS SPP_1576 NC_012467.1 1456377 1459073 R identified by match to protein family HMM PF00122; match to protein family HMM PF00689; match to protein family HMM PF00690; match to protein family HMM PF00702; match to protein family HMM TIGR01494; calcium-transporting ATPase 1 complement(1456377..1459073) Streptococcus pneumoniae P1031 7682599 YP_002738691.1 CDS SPP_1577 NC_012467.1 1459377 1460561 D identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation efflux family protein 1459377..1460561 Streptococcus pneumoniae P1031 7681518 YP_002738692.1 CDS SPP_1578 NC_012467.1 1460704 1462575 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1460704..1462575) Streptococcus pneumoniae P1031 7681856 YP_002738693.1 CDS SPP_1579 NC_012467.1 1462572 1463756 R catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase complement(1462572..1463756) Streptococcus pneumoniae P1031 7681069 YP_002738694.1 CDS dapB NC_012467.1 1463768 1464535 R catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase complement(1463768..1464535) Streptococcus pneumoniae P1031 7682094 YP_002738695.1 CDS SPP_1581 NC_012467.1 1464812 1465660 R identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; hypothetical protein complement(1464812..1465660) Streptococcus pneumoniae P1031 7682701 YP_002738696.1 CDS SPP_1582 NC_012467.1 1465662 1466036 R identified by match to protein family HMM PF06619; hypothetical protein complement(1465662..1466036) Streptococcus pneumoniae P1031 7681984 YP_002738697.1 CDS glmM NC_012467.1 1466110 1467462 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(1466110..1467462) Streptococcus pneumoniae P1031 7681669 YP_002738698.1 CDS SPP_1584 NC_012467.1 1467486 1468265 R identified by match to protein family HMM PF07949; lipoprotein, putative complement(1467486..1468265) Streptococcus pneumoniae P1031 7681058 YP_002738699.1 CDS SPP_1585 NC_012467.1 1468252 1469109 R identified by match to protein family HMM PF02457; match to protein family HMM TIGR00159; hypothetical protein complement(1468252..1469109) Streptococcus pneumoniae P1031 7682404 YP_002738700.1 CDS SPP_1586 NC_012467.1 1469245 1470213 D identified by match to protein family HMM PF00070; match to protein family HMM PF03486; match to protein family HMM PF07992; thioredoxin reductase 1469245..1470213 Streptococcus pneumoniae P1031 7681840 YP_002738701.1 CDS SPP_1587 NC_012467.1 1470247 1471158 R identified by match to protein family HMM PF02650; match to protein family HMM TIGR00647; hypothetical protein complement(1470247..1471158) Streptococcus pneumoniae P1031 7681632 YP_002738702.1 CDS SPP_1588 NC_012467.1 1471155 1472132 R identified by match to protein family HMM PF01933; match to protein family HMM TIGR01826; transporter complement(1471155..1472132) Streptococcus pneumoniae P1031 7681294 YP_002738703.1 CDS SPP_1589 NC_012467.1 1472129 1473019 R identified by match to protein family HMM PF03668; hypothetical protein complement(1472129..1473019) Streptococcus pneumoniae P1031 7682391 YP_002738704.1 CDS SPP_1590 NC_012467.1 1473071 1473451 R identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004; endoribonuclease L-PSP, putative complement(1473071..1473451) Streptococcus pneumoniae P1031 7682643 YP_002738705.1 CDS engB NC_012467.1 1473462 1474049 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(1473462..1474049) Streptococcus pneumoniae P1031 7682126 YP_002738706.1 CDS clpX NC_012467.1 1474058 1475290 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1474058..1475290) Streptococcus pneumoniae P1031 7682172 YP_002738707.1 CDS SPP_1593 NC_012467.1 1475322 1475492 R hypothetical protein complement(1475322..1475492) Streptococcus pneumoniae P1031 7682828 YP_002738708.1 CDS folA NC_012467.1 1475492 1475998 R identified by match to protein family HMM PF00186; dihydrofolate reductase complement(1475492..1475998) Streptococcus pneumoniae P1031 7681426 YP_002738709.1 CDS SPP_1595 NC_012467.1 1476128 1476646 R identified by match to protein family HMM PF00210; DNA protection during starvation protein complement(1476128..1476646) Streptococcus pneumoniae P1031 7681202 YP_002738710.1 CDS SPP_1596 NC_012467.1 1477143 1478615 R identified by match to protein family HMM PF01183; match to protein family HMM PF01473; 1,4-beta-N-acetylmuramidase complement(1477143..1478615) Streptococcus pneumoniae P1031 7682016 YP_002738711.1 CDS tpiA NC_012467.1 1478686 1479444 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(1478686..1479444) Streptococcus pneumoniae P1031 7681001 YP_002738712.1 CDS SPP_1598 NC_012467.1 1479542 1480219 R identified by match to protein family HMM PF04271; match to protein family HMM TIGR01446; DNA replication protein DnaD complement(1479542..1480219) Streptococcus pneumoniae P1031 7681595 YP_002738713.1 CDS metA NC_012467.1 1480228 1481172 R catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase complement(1480228..1481172) Streptococcus pneumoniae P1031 7681832 YP_002738714.1 CDS apt NC_012467.1 1481354 1481866 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(1481354..1481866) Streptococcus pneumoniae P1031 7681645 YP_002738715.1 CDS SPP_1601 NC_012467.1 1481953 1482711 R identified by match to protein family HMM PF08241; match to protein family HMM PF08242; SAM-dependent methyltransferase complement(1481953..1482711) Streptococcus pneumoniae P1031 7681682 YP_002738716.1 CDS SPP_1602 NC_012467.1 1482919 1483065 D chlorohydrolase 1482919..1483065 Streptococcus pneumoniae P1031 7681249 YP_002738717.1 CDS SPP_1603 NC_012467.1 1483212 1484342 R identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; multiple sugar-binding transport ATP-binding protein MsmK complement(1483212..1484342) Streptococcus pneumoniae P1031 7682007 YP_002738718.1 CDS SPP_1605 NC_012467.1 1484792 1485367 R identified by match to protein family HMM PF00857; isochorismatase complement(1484792..1485367) Streptococcus pneumoniae P1031 7680734 YP_002738719.1 CDS codY NC_012467.1 1485367 1486155 R CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY complement(1485367..1486155) Streptococcus pneumoniae P1031 7681757 YP_002738720.1 CDS SPP_1607 NC_012467.1 1486420 1487994 R identified by match to protein family HMM PF00270; match to protein family HMM PF00271; cold-shock DEAD box protein A complement(1486420..1487994) Streptococcus pneumoniae P1031 7682520 YP_002738721.1 CDS SPP_1608 NC_012467.1 1488193 1489419 R identified by match to protein family HMM PF07690; major facilitator:Oxalate:Formate Antiporter complement(1488193..1489419) Streptococcus pneumoniae P1031 7682056 YP_002738722.1 CDS SPP_1609 NC_012467.1 1489613 1490929 D Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 1489613..1490929 Streptococcus pneumoniae P1031 7681020 YP_002738723.1 CDS SPP_1610 NC_012467.1 1491028 1492371 D identified by match to protein family HMM PF08245; match to protein family HMM PF08353; Mur ligase family protein 1491028..1492371 Streptococcus pneumoniae P1031 7682298 YP_002738724.1 CDS SPP_1611 NC_012467.1 1492371 1493153 D identified by match to protein family HMM PF07685; cobyric acid synthase 1492371..1493153 Streptococcus pneumoniae P1031 7682576 YP_002738725.1 CDS SPP_1612 NC_012467.1 1493279 1494361 D identified by match to protein family HMM PF00557; match to protein family HMM PF01321; Xaa-Pro dipeptidase (X-Pro dipeptidase) (Prolinedipeptidase) (Prolidase) (Imidodipeptidase) 1493279..1494361 Streptococcus pneumoniae P1031 7681195 YP_002738726.1 CDS SPP_1613 NC_012467.1 1494354 1494557 D hypothetical protein 1494354..1494557 Streptococcus pneumoniae P1031 7681055 YP_002738727.1 CDS SPP_1614 NC_012467.1 1494682 1494900 R transposase OrfB complement(1494682..1494900) Streptococcus pneumoniae P1031 7682115 YP_002738728.1 CDS SPP_1617 NC_012467.1 1495576 1495764 D identified by glimmer; putative; hypothetical protein 1495576..1495764 Streptococcus pneumoniae P1031 7681435 YP_002738729.1 CDS SPP_1616 NC_012467.1 1495757 1496218 R hypothetical protein complement(1495757..1496218) Streptococcus pneumoniae P1031 7682563 YP_002738730.1 CDS SPP_1618 NC_012467.1 1496196 1496969 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(1496196..1496969) Streptococcus pneumoniae P1031 7681099 YP_002738731.1 CDS truA NC_012467.1 1496959 1497708 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(1496959..1497708) Streptococcus pneumoniae P1031 7681465 YP_002738732.1 CDS SPP_1620 NC_012467.1 1498026 1499177 R identified by match to protein family HMM PF07690; major facilitator superfamily transporter complement(1498026..1499177) Streptococcus pneumoniae P1031 7681804 YP_002738733.1 CDS SPP_1621 NC_012467.1 1499149 1499265 D identified by glimmer; putative; hypothetical protein 1499149..1499265 Streptococcus pneumoniae P1031 7680960 YP_002738734.1 CDS SPP_1622 NC_012467.1 1499417 1500046 R hypothetical protein complement(1499417..1500046) Streptococcus pneumoniae P1031 7681440 YP_002738735.1 CDS phnA NC_012467.1 1500049 1500387 R identified by match to protein family HMM PF03831; match to protein family HMM PF08274; match to protein family HMM TIGR00686; alkylphosphonate utilization operon protein PhnA complement(1500049..1500387) Streptococcus pneumoniae P1031 7680995 YP_002738736.1 CDS cmk NC_012467.1 1500518 1501189 R Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase complement(1500518..1501189) Streptococcus pneumoniae P1031 7682032 YP_002738737.1 CDS SPP_1625 NC_012467.1 1501198 1501674 R hypothetical protein complement(1501198..1501674) Streptococcus pneumoniae P1031 7682082 YP_002738738.1 CDS SPP_1626 NC_012467.1 1501816 1501932 D ferredoxin 1501816..1501932 Streptococcus pneumoniae P1031 7682521 YP_002738739.1 CDS SPP_1627 NC_012467.1 1501994 1502947 R identified by match to protein family HMM PF00535; bactoprenol glucosyl transferase complement(1501994..1502947) Streptococcus pneumoniae P1031 7682432 YP_002738740.1 CDS galE2 NC_012467.1 1502949 1503968 R identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase complement(1502949..1503968) Streptococcus pneumoniae P1031 7681911 YP_002738741.1 CDS SPP_1629 NC_012467.1 1504071 1504262 R identified by glimmer; putative; hypothetical protein complement(1504071..1504262) Streptococcus pneumoniae P1031 7681389 YP_002738742.1 CDS SPP_1630 NC_012467.1 1504269 1505372 R identified by match to protein family HMM PF01266; FAD dependent oxidoreductase complement(1504269..1505372) Streptococcus pneumoniae P1031 7681066 YP_002738743.1 CDS SPP_1631 NC_012467.1 1505389 1506186 R identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486; hypothetical protein complement(1505389..1506186) Streptococcus pneumoniae P1031 7682137 YP_002738744.1 CDS SPP_1632 NC_012467.1 1506173 1506850 R identified by match to protein family HMM PF04816; Bcl-2 family protein complement(1506173..1506850) Streptococcus pneumoniae P1031 7680694 YP_002738745.1 CDS SPP_1633 NC_012467.1 1507400 1508392 D hypothetical protein 1507400..1508392 Streptococcus pneumoniae P1031 7681445 YP_002738746.1 CDS SPP_1636 NC_012467.1 1509071 1509727 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(1509071..1509727) Streptococcus pneumoniae P1031 7681319 YP_002738747.1 CDS tkt1 NC_012467.1 1510100 1512070 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(1510100..1512070) Streptococcus pneumoniae P1031 7680705 YP_002738748.1 CDS SPP_1638 NC_012467.1 1512107 1512802 R identified by match to protein family HMM PF00834; allulose-6-phosphate 3-epimerase complement(1512107..1512802) Streptococcus pneumoniae P1031 7680899 YP_002738749.1 CDS SPP_1639 NC_012467.1 1512813 1513898 R identified by match to protein family HMM PF02378; match to protein family HMM TIGR01427; PTS system, IIC component complement(1512813..1513898) Streptococcus pneumoniae P1031 7682565 YP_002738750.1 CDS SPP_1641 NC_012467.1 1514263 1514712 R identified by match to protein family HMM PF00359; match to protein family HMM TIGR00848; PTS system, IIA component complement(1514263..1514712) Streptococcus pneumoniae P1031 7682797 YP_002738751.1 CDS SPP_1642 NC_012467.1 1514690 1515118 R identified by match to protein family HMM PF00359; PTS system, nitrogen regulatory component IIA, putative complement(1514690..1515118) Streptococcus pneumoniae P1031 7681273 YP_002738752.1 CDS SPP_1643 NC_012467.1 1515111 1516574 R identified by match to protein family HMM PF00874; match to protein family HMM PF05043; match to protein family HMM PF08279; putative transcription antiterminator BglG family protein complement(1515111..1516574) Streptococcus pneumoniae P1031 7681700 YP_002738753.1 CDS SPP_1644 NC_012467.1 1517103 1519439 R identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; P-type ATPase - metal cation transport complement(1517103..1519439) Streptococcus pneumoniae P1031 7682098 YP_002738754.1 CDS SPP_1645 NC_012467.1 1519572 1520321 D identified by match to protein family HMM PF01553; acyltransferase family protein 1519572..1520321 Streptococcus pneumoniae P1031 7682660 YP_002738755.1 CDS SPP_1646 NC_012467.1 1520614 1521228 R identified by match to protein family HMM PF03596; match to protein family HMM TIGR00779; CadD complement(1520614..1521228) Streptococcus pneumoniae P1031 7680983 YP_002738756.1 CDS rpsO NC_012467.1 1522044 1522313 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(1522044..1522313) Streptococcus pneumoniae P1031 7681896 YP_002738757.1 CDS SPP_1648 NC_012467.1 1522454 1523083 R YwnB complement(1522454..1523083) Streptococcus pneumoniae P1031 7681579 YP_002738758.1 CDS SPP_1649 NC_012467.1 1523942 1524265 D hypothetical protein 1523942..1524265 Streptococcus pneumoniae P1031 7681306 YP_002738759.1 CDS thrS NC_012467.1 1524323 1526266 D catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1524323..1526266 Streptococcus pneumoniae P1031 7681679 YP_002738760.1 CDS SPP_1651 NC_012467.1 1526315 1527289 R identified by match to protein family HMM PF02518; histidine kinase complement(1526315..1527289) Streptococcus pneumoniae P1031 7681625 YP_002738761.1 CDS SPP_1652 NC_012467.1 1527282 1527959 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator complement(1527282..1527959) Streptococcus pneumoniae P1031 7681901 YP_002738762.1 CDS SPP_1653 NC_012467.1 1528115 1529188 D hypothetical protein 1528115..1529188 Streptococcus pneumoniae P1031 7682519 YP_002738763.1 CDS SPP_1654 NC_012467.1 1529279 1529581 R hypothetical protein complement(1529279..1529581) Streptococcus pneumoniae P1031 7682737 YP_002738764.1 CDS SPP_1655 NC_012467.1 1529649 1530086 R identified by match to protein family HMM PF02082; Rrf2 family protein complement(1529649..1530086) Streptococcus pneumoniae P1031 7682050 YP_002738765.1 CDS SPP_1656 NC_012467.1 1530162 1531004 R identified by match to protein family HMM PF00149; metallophosphoesterase complement(1530162..1531004) Streptococcus pneumoniae P1031 7680856 YP_002738766.1 CDS SPP_1657 NC_012467.1 1531116 1531766 D identified by match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF02742; match to protein family HMM PF04023; iron-dependent transcriptional regulator 1531116..1531766 Streptococcus pneumoniae P1031 7681942 YP_002738767.1 CDS SPP_1658 NC_012467.1 1531747 1531938 D hypothetical protein 1531747..1531938 Streptococcus pneumoniae P1031 7682431 YP_002738768.1 CDS SPP_1659 NC_012467.1 1531964 1532611 D hypothetical protein 1531964..1532611 Streptococcus pneumoniae P1031 7680681 YP_002738769.1 CDS SPP_1660 NC_012467.1 1532742 1533155 D hypothetical protein 1532742..1533155 Streptococcus pneumoniae P1031 7682109 YP_002738770.1 CDS SPP_1661 NC_012467.1 1533174 1533359 D hypothetical protein 1533174..1533359 Streptococcus pneumoniae P1031 7680910 YP_002738771.1 CDS SPP_1662 NC_012467.1 1533426 1533587 D identified by glimmer; putative; hypothetical protein 1533426..1533587 Streptococcus pneumoniae P1031 7681623 YP_002738772.1 CDS dtd NC_012467.1 1533626 1534069 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(1533626..1534069) Streptococcus pneumoniae P1031 7680781 YP_002738773.1 CDS spoT NC_012467.1 1534099 1536321 R identified by match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691; guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase complement(1534099..1536321) Streptococcus pneumoniae P1031 7680929 YP_002738774.1 CDS SPP_1665 NC_012467.1 1537317 1537946 D identified by match to protein family HMM PF00753; metallo-beta-lactamase superfamily protein 1537317..1537946 Streptococcus pneumoniae P1031 7681677 YP_002738775.1 CDS SPP_1666 NC_012467.1 1538069 1539961 R identified by match to protein family HMM PF01431; match to protein family HMM PF05649; endopeptidase O complement(1538069..1539961) Streptococcus pneumoniae P1031 7682681 YP_002738776.1 CDS SPP_1667 NC_012467.1 1540252 1540974 D identified by match to protein family HMM PF00005; manganese transport system ATP-binding protein MntA 1540252..1540974 Streptococcus pneumoniae P1031 7682139 YP_002738777.1 CDS SPP_1668 NC_012467.1 1540971 1541819 D identified by match to protein family HMM PF00950; manganese transport system membrane protein MntB 1540971..1541819 Streptococcus pneumoniae P1031 7681696 YP_002738778.1 CDS SPP_1669 NC_012467.1 1541851 1542780 D identified by match to protein family HMM PF01297; manganese ABC transporter substrate-binding lipoprotein (Adhesin B) (Saliva-binding protein) 1541851..1542780 Streptococcus pneumoniae P1031 7682807 YP_002738779.1 CDS tpx NC_012467.1 1542903 1543394 D antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1542903..1543394 Streptococcus pneumoniae P1031 7681671 YP_002738780.1 CDS SPP_1671 NC_012467.1 1543490 1546198 R identified by match to protein family HMM PF02687; efflux ABC transporter, permease protein complement(1543490..1546198) Streptococcus pneumoniae P1031 7681415 YP_002738781.1 CDS SPP_1672 NC_012467.1 1546200 1546901 R identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease protein MacB complement(1546200..1546901) Streptococcus pneumoniae P1031 7681831 YP_002738782.1 CDS SPP_1673 NC_012467.1 1547151 1549562 R alpha-fucosidase complement(1547151..1549562) Streptococcus pneumoniae P1031 7682463 YP_002738783.1 CDS gpmA NC_012467.1 1549615 1550307 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(1549615..1550307) Streptococcus pneumoniae P1031 7681540 YP_002738784.1 CDS SPP_1675 NC_012467.1 1550358 1550648 R hypothetical protein complement(1550358..1550648) Streptococcus pneumoniae P1031 7681658 YP_002738785.1 CDS SPP_1676 NC_012467.1 1550842 1551222 R prophage Lp1 protein 6 complement(1550842..1551222) Streptococcus pneumoniae P1031 7682275 YP_002738786.1 CDS ileS NC_012467.1 1551625 1554417 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase complement(1551625..1554417) Streptococcus pneumoniae P1031 7682709 YP_002738787.1 CDS SPP_1678 NC_012467.1 1554670 1554786 R hypothetical protein complement(1554670..1554786) Streptococcus pneumoniae P1031 7681209 YP_002738788.1 CDS SPP_1679 NC_012467.1 1554765 1555553 R identified by match to protein family HMM PF05103; cell-division initiation protein complement(1554765..1555553) Streptococcus pneumoniae P1031 7682537 YP_002738789.1 CDS SPP_1680 NC_012467.1 1555562 1556347 R identified by match to protein family HMM PF01479; YlmH protein complement(1555562..1556347) Streptococcus pneumoniae P1031 7681542 YP_002738790.1 CDS SPP_1681 NC_012467.1 1556344 1556607 R identified by match to protein family HMM PF02325; yggt family, putative complement(1556344..1556607) Streptococcus pneumoniae P1031 7680635 YP_002738791.1 CDS SPP_1682 NC_012467.1 1556607 1557146 R identified by match to protein family HMM PF04472; YlmF protein complement(1556607..1557146) Streptococcus pneumoniae P1031 7682271 YP_002738792.1 CDS SPP_1683 NC_012467.1 1557156 1557827 R identified by match to protein family HMM TIGR00044; pyridoxal phosphate enzyme, YggS family complement(1557156..1557827) Streptococcus pneumoniae P1031 7681709 YP_002738793.1 CDS ftsZ NC_012467.1 1557832 1559091 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(1557832..1559091) Streptococcus pneumoniae P1031 7680897 YP_002738794.1 CDS ftsA NC_012467.1 1559108 1560481 R identified by match to protein family HMM PF02491; match to protein family HMM TIGR01174; cell division protein FtsA complement(1559108..1560481) Streptococcus pneumoniae P1031 7680802 YP_002738795.1 CDS SPP_1686 NC_012467.1 1560700 1561404 R identified by match to protein family HMM TIGR02206; hypothetical protein complement(1560700..1561404) Streptococcus pneumoniae P1031 7681468 YP_002738796.1 CDS SPP_1687 NC_012467.1 1561495 1562106 R identified by match to protein family HMM PF00293; MutT/nudix family protein complement(1561495..1562106) Streptococcus pneumoniae P1031 7681650 YP_002738797.1 CDS SPP_1688 NC_012467.1 1562093 1563466 R identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01143; UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase complement(1562093..1563466) Streptococcus pneumoniae P1031 7681005 YP_002738798.1 CDS ddl NC_012467.1 1563550 1564593 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(1563550..1564593) Streptococcus pneumoniae P1031 7682307 YP_002738799.1 CDS recR NC_012467.1 1564788 1565384 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(1564788..1565384) Streptococcus pneumoniae P1031 7681830 YP_002738800.1 CDS SPP_1691 NC_012467.1 1565395 1567437 R identified by match to protein family HMM PF00905; match to protein family HMM PF03717; penicillin-binding protein 2B complement(1565395..1567437) Streptococcus pneumoniae P1031 7681355 YP_002738801.1 CDS SPP_1692 NC_012467.1 1567652 1568503 D identified by match to protein family HMM PF01380; match to protein family HMM PF01418; transcriptional regulator, RpiR family 1567652..1568503 Streptococcus pneumoniae P1031 7681037 YP_002738802.1 CDS SPP_1693 NC_012467.1 1568519 1569403 R identified by match to protein family HMM PF00480; glucokinase complement(1568519..1569403) Streptococcus pneumoniae P1031 7682429 YP_002738803.1 CDS SPP_1694 NC_012467.1 1569421 1570338 R identified by match to protein family HMM PF00701; N-acetylneuraminate lyase complement(1569421..1570338) Streptococcus pneumoniae P1031 7682327 YP_002738804.1 CDS SPP_1695 NC_012467.1 1570507 1571151 R identified by match to protein family HMM PF04854; hypothetical protein complement(1570507..1571151) Streptococcus pneumoniae P1031 7681673 YP_002738805.1 CDS SPP_1696 NC_012467.1 1571499 1571651 D identified by glimmer; putative; hypothetical protein 1571499..1571651 Streptococcus pneumoniae P1031 7681106 YP_002738806.1 CDS SPP_1697 NC_012467.1 1571876 1572328 R identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein complement(1571876..1572328) Streptococcus pneumoniae P1031 7682609 YP_002738807.1 CDS SPP_1698 NC_012467.1 1572600 1573439 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1572600..1573439) Streptococcus pneumoniae P1031 7680915 YP_002738808.1 CDS SPP_1699 NC_012467.1 1573455 1574342 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1573455..1574342) Streptococcus pneumoniae P1031 7682160 YP_002738809.1 CDS SPP_1700 NC_012467.1 1574574 1575902 R identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein complement(1574574..1575902) Streptococcus pneumoniae P1031 7682821 YP_002738810.1 CDS SPP_1701 NC_012467.1 1576027 1577544 R identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; pts system maltose- and glucose-specific eiicb component complement(1576027..1577544) Streptococcus pneumoniae P1031 7682184 YP_002738811.1 CDS SPP_1702 NC_012467.1 1577563 1578261 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(1577563..1578261) Streptococcus pneumoniae P1031 7682674 YP_002738812.1 CDS SPP_1703 NC_012467.1 1578434 1579537 R identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; match to protein family HMM PF03447; putative oxidoreductase YjhC complement(1578434..1579537) Streptococcus pneumoniae P1031 7682607 YP_002738813.1 CDS SPP_1704 NC_012467.1 1579549 1581642 R identified by match to protein family HMM PF02012; match to protein family HMM PF02973; sialidase B (Neuraminidase B) complement(1579549..1581642) Streptococcus pneumoniae P1031 7682492 YP_002738814.1 CDS SPP_1705 NC_012467.1 1581660 1582493 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1581660..1582493) Streptococcus pneumoniae P1031 7681571 YP_002738815.1 CDS SPP_1706 NC_012467.1 1582493 1583377 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1582493..1583377) Streptococcus pneumoniae P1031 7680634 YP_002738816.1 CDS SPP_1707 NC_012467.1 1583456 1584793 R identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein complement(1583456..1584793) Streptococcus pneumoniae P1031 7682833 YP_002738817.1 CDS SPP_1708 NC_012467.1 1584812 1585264 R identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein complement(1584812..1585264) Streptococcus pneumoniae P1031 7681383 YP_002738818.1 CDS SPP_1709 NC_012467.1 1586277 1589345 R identified by match to protein family HMM PF02012; match to protein family HMM PF02973; match to protein family HMM TIGR01167; neuraminidase complement(1586277..1589345) Streptococcus pneumoniae P1031 7681102 YP_002738819.1 CDS SPP_1710 NC_012467.1 1589702 1589929 R hypothetical protein complement(1589702..1589929) Streptococcus pneumoniae P1031 7680869 YP_002738820.1 CDS SPP_1712 NC_012467.1 1591049 1592029 R identified by match to protein family HMM PF05448; xylan esterase 1 complement(1591049..1592029) Streptococcus pneumoniae P1031 7680800 YP_002738821.1 CDS recG NC_012467.1 1592345 1594360 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(1592345..1594360) Streptococcus pneumoniae P1031 7682482 YP_002738822.1 CDS alr NC_012467.1 1594379 1595482 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(1594379..1595482) Streptococcus pneumoniae P1031 7682858 YP_002738823.1 CDS acpS NC_012467.1 1595472 1595834 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(1595472..1595834) Streptococcus pneumoniae P1031 7682209 YP_002738824.1 CDS SPP_1716 NC_012467.1 1595879 1596910 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1595879..1596910) Streptococcus pneumoniae P1031 7682529 YP_002738825.1 CDS SPP_1717 NC_012467.1 1596912 1597943 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1596912..1597943) Streptococcus pneumoniae P1031 7681473 YP_002738826.1 CDS secA NC_012467.1 1598024 1600537 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(1598024..1600537) Streptococcus pneumoniae P1031 7680940 YP_002738827.1 CDS SPP_1719 NC_012467.1 1600683 1600796 R identified by glimmer; putative; hypothetical protein complement(1600683..1600796) Streptococcus pneumoniae P1031 7681811 YP_002738828.1 CDS SPP_1720 NC_012467.1 1601000 1601632 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1601000..1601632) Streptococcus pneumoniae P1031 7681318 YP_002738829.1 CDS SPP_1721 NC_012467.1 1601636 1602211 R hypothetical protein complement(1601636..1602211) Streptococcus pneumoniae P1031 7682076 YP_002738830.1 CDS SPP_1722 NC_012467.1 1602270 1603061 R hypothetical protein complement(1602270..1603061) Streptococcus pneumoniae P1031 7682680 YP_002738831.1 CDS SPP_1723 NC_012467.1 1603246 1603581 R hypothetical protein complement(1603246..1603581) Streptococcus pneumoniae P1031 7681060 YP_002738832.1 CDS SPP_1724 NC_012467.1 1603721 1604059 R hypothetical protein complement(1603721..1604059) Streptococcus pneumoniae P1031 7681362 YP_002738833.1 CDS engA NC_012467.1 1604147 1605457 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(1604147..1605457) Streptococcus pneumoniae P1031 7681631 YP_002738834.1 CDS SPP_1726 NC_012467.1 1605471 1606184 R identified by match to protein family HMM PF00881; nitroreductase family protein complement(1605471..1606184) Streptococcus pneumoniae P1031 7682619 YP_002738835.1 CDS SPP_1727 NC_012467.1 1606181 1607077 R Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI complement(1606181..1607077) Streptococcus pneumoniae P1031 7682078 YP_002738836.1 CDS SPP_1728 NC_012467.1 1607078 1608247 R identified by match to protein family HMM PF07261; replication initiation and membrane attachment protein complement(1607078..1608247) Streptococcus pneumoniae P1031 7681987 YP_002738837.1 CDS nrdR NC_012467.1 1608248 1608721 R identified by match to protein family HMM PF03477; match to protein family HMM TIGR00244; transcriptional regulator NrdR complement(1608248..1608721) Streptococcus pneumoniae P1031 7682412 YP_002738838.1 CDS SPP_1730 NC_012467.1 1608861 1609226 D identified by match to protein family HMM PF00392; GntR family transcriptional regulator 1608861..1609226 Streptococcus pneumoniae P1031 7682389 YP_002738839.1 CDS SPP_1731 NC_012467.1 1609231 1609926 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1609231..1609926 Streptococcus pneumoniae P1031 7681455 YP_002738840.1 CDS SPP_1732 NC_012467.1 1609943 1610710 D hypothetical protein 1609943..1610710 Streptococcus pneumoniae P1031 7681521 YP_002738841.1 CDS SPP_1733 NC_012467.1 1611063 1612262 R Na+ ABC transporter permease complement(1611063..1612262) Streptococcus pneumoniae P1031 7680913 YP_002738842.1 CDS SPP_1734 NC_012467.1 1612259 1613152 R identified by match to protein family HMM PF00005; Na+ ABC transporter ATP-binding protein complement(1612259..1613152) Streptococcus pneumoniae P1031 7682322 YP_002738843.1 CDS SPP_1735 NC_012467.1 1613275 1613646 D hypothetical protein 1613275..1613646 Streptococcus pneumoniae P1031 7681912 YP_002738844.1 CDS SPP_1736 NC_012467.1 1614642 1615259 D identified by match to protein family HMM PF09335; hypothetical protein 1614642..1615259 Streptococcus pneumoniae P1031 7680837 YP_002738845.1 CDS SPP_1737 NC_012467.1 1615302 1616189 R identified by match to protein family HMM PF00480; fructokinase complement(1615302..1616189) Streptococcus pneumoniae P1031 7682192 YP_002738846.1 CDS SPP_1738 NC_012467.1 1616338 1618221 R identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01996; pts system, sucrose-specific iibc component complement(1616338..1618221) Streptococcus pneumoniae P1031 7682768 YP_002738847.1 CDS SPP_1739 NC_012467.1 1618347 1618544 R hypothetical protein complement(1618347..1618544) Streptococcus pneumoniae P1031 7680989 YP_002738848.1 CDS SPP_1740 NC_012467.1 1618597 1620051 D identified by match to protein family HMM PF00251; match to protein family HMM PF08244; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase (Sucrase) (Invertase) 1618597..1620051 Streptococcus pneumoniae P1031 7681630 YP_002738849.1 CDS SPP_1741 NC_012467.1 1620032 1620997 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sucrose operon repressor (Scr operon regulatory protein) 1620032..1620997 Streptococcus pneumoniae P1031 7681821 YP_002738850.1 CDS SPP_1744 NC_012467.1 1622307 1623503 R identified by match to protein family HMM PF01154; match to protein family HMM PF08540; match to protein family HMM TIGR01835; hydroxymethylglutaryl-CoA synthase complement(1622307..1623503) Streptococcus pneumoniae P1031 7680858 YP_002738851.1 CDS SPP_1745 NC_012467.1 1623610 1623858 R hypothetical protein complement(1623610..1623858) Streptococcus pneumoniae P1031 7682636 YP_002738852.1 CDS SPP_1746 NC_012467.1 1623926 1624315 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) complement(1623926..1624315) Streptococcus pneumoniae P1031 7682063 YP_002738853.1 CDS SPP_1747 NC_012467.1 1624332 1624547 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element complement(1624332..1624547) Streptococcus pneumoniae P1031 7681506 YP_002738854.1 CDS SPP_1748 NC_012467.1 1624612 1625061 R hypothetical protein complement(1624612..1625061) Streptococcus pneumoniae P1031 7682210 YP_002738855.1 CDS SPP_1749 NC_012467.1 1625063 1625821 R identified by match to protein family HMM PF06738; hypothetical protein complement(1625063..1625821) Streptococcus pneumoniae P1031 7680942 YP_002738856.1 CDS SPP_1750 NC_012467.1 1625936 1627915 R identified by match to protein family HMM PF00069; match to protein family HMM PF01163; match to protein family HMM PF03793; Stk1 complement(1625936..1627915) Streptococcus pneumoniae P1031 7681371 YP_002738857.1 CDS SPP_1751 NC_012467.1 1627912 1628652 R identified by match to protein family HMM PF00481; protein phosphatase PrpC complement(1627912..1628652) Streptococcus pneumoniae P1031 7682227 YP_002738858.1 CDS sun NC_012467.1 1628667 1629980 R identified by match to protein family HMM PF01029; match to protein family HMM PF01189; match to protein family HMM TIGR00563; ribosomal RNA small subunit methyltransferase B complement(1628667..1629980) Streptococcus pneumoniae P1031 7682513 YP_002738859.1 CDS fmt NC_012467.1 1629973 1630908 R modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase complement(1629973..1630908) Streptococcus pneumoniae P1031 7681181 YP_002738860.1 CDS SPP_1754 NC_012467.1 1630921 1633317 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(1630921..1633317) Streptococcus pneumoniae P1031 7680685 YP_002738861.1 CDS SPP_1755 NC_012467.1 1633383 1633694 R Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(1633383..1633694) Streptococcus pneumoniae P1031 7682813 YP_002738862.1 CDS gmk NC_012467.1 1633722 1634348 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(1633722..1634348) Streptococcus pneumoniae P1031 7682277 YP_002738863.1 CDS SPP_1757 NC_012467.1 1634478 1636091 R identified by match to protein family HMM PF00013; match to protein family HMM PF01966; match to protein family HMM TIGR00277; match to protein family HMM TIGR03319; hypothetical protein complement(1634478..1636091) Streptococcus pneumoniae P1031 7681763 YP_002738864.1 CDS SPP_1758 NC_012467.1 1636434 1639181 R hypothetical protein complement(1636434..1639181) Streptococcus pneumoniae P1031 7681548 YP_002738865.1 CDS SPP_1759 NC_012467.1 1639528 1640625 R identified by match to protein family HMM PF05636; hypothetical protein complement(1639528..1640625) Streptococcus pneumoniae P1031 7682461 YP_002738866.1 CDS SPP_1760 NC_012467.1 1640635 1641381 R identified by match to protein family HMM PF08241; match to protein family HMM PF08242; SAM-dependent methyltransferase complement(1640635..1641381) Streptococcus pneumoniae P1031 7682546 YP_002738867.1 CDS SPP_1761 NC_012467.1 1641484 1641837 R identified by match to protein family HMM PF02410; match to protein family HMM TIGR00090; putative iojap homolog complement(1641484..1641837) Streptococcus pneumoniae P1031 7682292 YP_002738868.1 CDS SPP_1762 NC_012467.1 1641850 1642350 R identified by match to protein family HMM PF00857; isochorismatase family protein complement(1641850..1642350) Streptococcus pneumoniae P1031 7680629 YP_002738869.1 CDS SPP_1763 NC_012467.1 1642351 1642944 R identified by match to protein family HMM PF01966; match to protein family HMM TIGR00277; match to protein family HMM TIGR00488; hypothetical protein complement(1642351..1642944) Streptococcus pneumoniae P1031 7681552 YP_002738870.1 CDS nadD NC_012467.1 1642944 1643573 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(1642944..1643573) Streptococcus pneumoniae P1031 7680967 YP_002738871.1 CDS SPP_1765 NC_012467.1 1643625 1643936 R identified by match to protein family HMM PF01985; match to protein family HMM TIGR00253; hypothetical protein complement(1643625..1643936) Streptococcus pneumoniae P1031 7681203 YP_002738872.1 CDS SPP_1766 NC_012467.1 1644150 1645256 R in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH complement(1644150..1645256) Streptococcus pneumoniae P1031 7681228 YP_002738873.1 CDS yqeG NC_012467.1 1645259 1645786 R identified by match to protein family HMM TIGR01662; match to protein family HMM TIGR01668; had superfamily (subfamily iiia) phosphatase complement(1645259..1645786) Streptococcus pneumoniae P1031 7681269 YP_002738874.1 CDS SPP_1768 NC_012467.1 1645801 1646709 R identified by match to protein family HMM PF01544; CorA - magnesium and cobalt transporter complement(1645801..1646709) Streptococcus pneumoniae P1031 7682590 YP_002738875.1 CDS SPP_1769 NC_012467.1 1646766 1647326 R identified by match to protein family HMM PF00924; small conductance mechanosensitive ion channel complement(1646766..1647326) Streptococcus pneumoniae P1031 7681096 YP_002738876.1 CDS SPP_1772 NC_012467.1 1648741 1649694 D identified by match to protein family HMM PF06081; integral membrane protein 1648741..1649694 Streptococcus pneumoniae P1031 7681906 YP_002738877.1 CDS SPP_1773 NC_012467.1 1649837 1650217 D identified by match to protein family HMM PF01047; transcriptional regulator, putative 1649837..1650217 Streptococcus pneumoniae P1031 7681959 YP_002738878.1 CDS SPP_1774 NC_012467.1 1650316 1650537 D hypothetical protein 1650316..1650537 Streptococcus pneumoniae P1031 7681085 YP_002738879.1 CDS trx NC_012467.1 1650554 1650868 D identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin 1650554..1650868 Streptococcus pneumoniae P1031 7682159 YP_002738880.1 CDS SPP_1776 NC_012467.1 1651173 1651706 D NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 1651173..1651706 Streptococcus pneumoniae P1031 7681282 YP_002738881.1 CDS SPP_1777 NC_012467.1 1651960 1652628 R identified by match to protein family HMM PF00230; aquaporin Z - water channel protein complement(1651960..1652628) Streptococcus pneumoniae P1031 7682297 YP_002738882.1 CDS SPP_1778 NC_012467.1 1652739 1653530 R hypothetical protein complement(1652739..1653530) Streptococcus pneumoniae P1031 7682583 YP_002738883.1 CDS SPP_1779 NC_012467.1 1653954 1654718 R identified by match to protein family HMM PF01061; ABC transporter complement(1653954..1654718) Streptococcus pneumoniae P1031 7681325 YP_002738884.1 CDS SPP_1780 NC_012467.1 1654711 1655481 R identified by match to protein family HMM PF00005; Nod factor export ATP-binding protein I (Nodulation ATP-binding protein I) complement(1654711..1655481) Streptococcus pneumoniae P1031 7682012 YP_002738885.1 CDS SPP_1781 NC_012467.1 1655728 1656405 D identified by match to protein family HMM PF01022; transcriptional regulator, ArsR family 1655728..1656405 Streptococcus pneumoniae P1031 7681022 YP_002738886.1 CDS pepF2 NC_012467.1 1656465 1658261 R identified by match to protein family HMM PF01432; match to protein family HMM PF08439; match to protein family HMM TIGR00181; oligoendopeptidase F complement(1656465..1658261) Streptococcus pneumoniae P1031 7681138 YP_002738887.1 CDS SPP_1783 NC_012467.1 1658272 1659015 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(1658272..1659015) Streptococcus pneumoniae P1031 7682229 YP_002738888.1 CDS prmA NC_012467.1 1659017 1659967 R methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase complement(1659017..1659967) Streptococcus pneumoniae P1031 7681110 YP_002738889.1 CDS SPP_1785 NC_012467.1 1660105 1660533 R identified by match to protein family HMM PF00293; MutT/nudix family protein complement(1660105..1660533) Streptococcus pneumoniae P1031 7682187 YP_002738890.1 CDS SPP_1786 NC_012467.1 1660514 1661602 R identified by match to protein family HMM PF02163; peptidase, M50 family protein complement(1660514..1661602) Streptococcus pneumoniae P1031 7682824 YP_002738891.1 CDS SPP_1787 NC_012467.1 1661621 1662091 R hypothetical protein complement(1661621..1662091) Streptococcus pneumoniae P1031 7682614 YP_002738892.1 CDS SPP_1788 NC_012467.1 1662382 1662834 R identified by match to protein family HMM PF03681; hypothetical protein complement(1662382..1662834) Streptococcus pneumoniae P1031 7681573 YP_002738893.1 CDS SPP_1789 NC_012467.1 1663186 1663365 R hypothetical protein complement(1663186..1663365) Streptococcus pneumoniae P1031 7681191 YP_002738894.1 CDS SPP_1790 NC_012467.1 1663530 1663769 R hypothetical protein complement(1663530..1663769) Streptococcus pneumoniae P1031 7681401 YP_002738895.1 CDS SPP_1791 NC_012467.1 1664039 1665310 D identified by match to protein family HMM PF00004; recombination factor protein RarA 1664039..1665310 Streptococcus pneumoniae P1031 7680832 YP_002738896.1 CDS SPP_1793 NC_012467.1 1665857 1667176 R identified by match to protein family HMM PF00251; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase complement(1665857..1667176) Streptococcus pneumoniae P1031 7680759 YP_002738897.1 CDS SPP_1794 NC_012467.1 1667186 1668031 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1667186..1668031) Streptococcus pneumoniae P1031 7680828 YP_002738898.1 CDS SPP_1795 NC_012467.1 1668033 1668935 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1668033..1668935) Streptococcus pneumoniae P1031 7681910 YP_002738899.1 CDS SPP_1796 NC_012467.1 1669031 1670341 R identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein complement(1669031..1670341) Streptococcus pneumoniae P1031 7681582 YP_002738900.1 CDS SPP_1797 NC_012467.1 1670468 1671463 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sugar-binding transcriptional regulator, LacI family protein complement(1670468..1671463) Streptococcus pneumoniae P1031 7682223 YP_002738901.1 CDS SPP_1798 NC_012467.1 1671825 1673306 R identified by match to protein family HMM PF05043; match to protein family HMM PF08270; match to protein family HMM PF08279; match to protein family HMM PF08280; M protein trans-acting positive transcriptional regulator complement(1671825..1673306) Streptococcus pneumoniae P1031 7681360 YP_002738902.1 CDS SPP_1799 NC_012467.1 1673749 1673913 D identified by match to protein family HMM PF04226; hypothetical protein 1673749..1673913 Streptococcus pneumoniae P1031 7681052 YP_002738903.1 CDS SPP_1800 NC_012467.1 1673997 1674563 D hypothetical protein 1673997..1674563 Streptococcus pneumoniae P1031 7682695 YP_002738904.1 CDS SPP_1801 NC_012467.1 1674575 1674745 D lipoprotein, putative 1674575..1674745 Streptococcus pneumoniae P1031 7681592 YP_002738905.1 CDS SPP_1802 NC_012467.1 1674784 1675392 D identified by match to protein family HMM PF03780; Gls24 protein 1674784..1675392 Streptococcus pneumoniae P1031 7681880 YP_002738906.1 CDS SPP_1803 NC_012467.1 1675423 1675626 D identified by match to protein family HMM PF05532; hypothetical protein 1675423..1675626 Streptococcus pneumoniae P1031 7681171 YP_002738907.1 CDS SPP_1804 NC_012467.1 1676440 1676559 R identified by glimmer; putative; hypothetical protein complement(1676440..1676559) Streptococcus pneumoniae P1031 7681281 YP_002738908.1 CDS SPP_1805 NC_012467.1 1676777 1677484 R identified by match to protein family HMM PF01925; hypothetical protein complement(1676777..1677484) Streptococcus pneumoniae P1031 7681253 YP_002738909.1 CDS SPP_1806 NC_012467.1 1677562 1678008 R identified by match to protein family HMM PF03781; sulfatase-modifying factor 1 (C-alpha-formyglycine-generating enzyme 1) complement(1677562..1678008) Streptococcus pneumoniae P1031 7681295 YP_002738910.1 CDS SPP_1807 NC_012467.1 1678094 1678696 R phosphotransferase system complement(1678094..1678696) Streptococcus pneumoniae P1031 7681923 YP_002738911.1 CDS SPP_1810 NC_012467.1 1679039 1679356 R identified by match to protein family HMM PF02302; lichenan-specific phosphotransferase enzyme iib component (pts system lichenan-specific eiib component) (eiib-lic) complement(1679039..1679356) Streptococcus pneumoniae P1031 7681551 YP_002738912.1 CDS SPP_1811 NC_012467.1 1679371 1680267 R hypothetical protein complement(1679371..1680267) Streptococcus pneumoniae P1031 7680963 YP_002738913.1 CDS SPP_1812 NC_012467.1 1680270 1681532 R identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) complement(1680270..1681532) Streptococcus pneumoniae P1031 7680891 YP_002738914.1 CDS SPP_1813 NC_012467.1 1681812 1682990 D identified by match to protein family HMM PF00480; ROK family protein, putative 1681812..1682990 Streptococcus pneumoniae P1031 7682371 YP_002738915.1 CDS SPP_1814 NC_012467.1 1683218 1683664 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family complement(1683218..1683664) Streptococcus pneumoniae P1031 7682874 YP_002738916.1 CDS SPP_1815 NC_012467.1 1683734 1684393 D identified by match to protein family HMM PF01478; match to protein family HMM PF06750; type 4 prepilin peptidase 1683734..1684393 Streptococcus pneumoniae P1031 7682134 YP_002738917.1 CDS SPP_1816 NC_012467.1 1684445 1685596 R identified by match to protein family HMM PF01381; match to protein family HMM PF06114; transcriptional regulator complement(1684445..1685596) Streptococcus pneumoniae P1031 7682473 YP_002738918.1 CDS SPP_1817 NC_012467.1 1685611 1686165 R identified by glimmer; putative; hypothetical protein complement(1685611..1686165) Streptococcus pneumoniae P1031 7682757 YP_002738919.1 CDS SPP_1818 NC_012467.1 1686202 1686342 R identified by glimmer; putative; hypothetical protein complement(1686202..1686342) Streptococcus pneumoniae P1031 7681738 YP_002738920.1 CDS trpA NC_012467.1 1686644 1687420 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1686644..1687420) Streptococcus pneumoniae P1031 7681408 YP_002738921.1 CDS trpB NC_012467.1 1687413 1688636 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1687413..1688636) Streptococcus pneumoniae P1031 7681559 YP_002738922.1 CDS trpF NC_012467.1 1688614 1689213 R catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase complement(1688614..1689213) Streptococcus pneumoniae P1031 7681918 YP_002738923.1 CDS trpC NC_012467.1 1689200 1689967 R involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase complement(1689200..1689967) Streptococcus pneumoniae P1031 7681262 YP_002738924.1 CDS trpD NC_012467.1 1689964 1690968 R Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase complement(1689964..1690968) Streptococcus pneumoniae P1031 7681270 YP_002738925.1 CDS SPP_1824 NC_012467.1 1690979 1691545 R TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II complement(1690979..1691545) Streptococcus pneumoniae P1031 7681931 YP_002738926.1 CDS trpE NC_012467.1 1691542 1692903 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1691542..1692903) Streptococcus pneumoniae P1031 7682423 YP_002738927.1 CDS SPP_1826 NC_012467.1 1693275 1693436 R hypothetical protein complement(1693275..1693436) Streptococcus pneumoniae P1031 7681524 YP_002738928.1 CDS SPP_1827 NC_012467.1 1694044 1695045 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; catabolite control protein complement(1694044..1695045) Streptococcus pneumoniae P1031 7681376 YP_002738929.1 CDS SPP_1828 NC_012467.1 1695617 1696327 R identified by match to protein family HMM PF02308; putative Mg2+ transporter-C (MgtC) family protein complement(1695617..1696327) Streptococcus pneumoniae P1031 7682706 YP_002738930.1 CDS SPP_1829 NC_012467.1 1696330 1698021 R identified by match to protein family HMM PF00528; binding-protein-dependent transport systems inner membrane component complement(1696330..1698021) Streptococcus pneumoniae P1031 7682089 YP_002738931.1 CDS SPP_1830 NC_012467.1 1698033 1699043 R identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; spermidine/putrescine import ATP-binding protein PotA complement(1698033..1699043) Streptococcus pneumoniae P1031 7681705 YP_002738932.1 CDS SPP_1831 NC_012467.1 1699146 1700213 R ABC transporter substrate-binding protein complement(1699146..1700213) Streptococcus pneumoniae P1031 7681794 YP_002738933.1 CDS SPP_1832 NC_012467.1 1700238 1700897 R identified by match to protein family HMM PF08975; hypothetical protein complement(1700238..1700897) Streptococcus pneumoniae P1031 7681975 YP_002738934.1 CDS SPP_1833 NC_012467.1 1701022 1701135 R hypothetical protein complement(1701022..1701135) Streptococcus pneumoniae P1031 7682601 YP_002738935.1 CDS SPP_1834 NC_012467.1 1701916 1704042 R identified by match to protein family HMM PF04650; match to protein family HMM TIGR01168; cell wall surface anchor family protein complement(1701916..1704042) Streptococcus pneumoniae P1031 7682586 YP_002738936.1 CDS SPP_1835 NC_012467.1 1705205 1706431 R identified by match to protein family HMM PF01041; Cps7G complement(1705205..1706431) Streptococcus pneumoniae P1031 7681748 YP_002738937.1 CDS SPP_1836 NC_012467.1 1706474 1707166 R identified by match to protein family HMM PF02397; putative glycosyl transferase complement(1706474..1707166) Streptococcus pneumoniae P1031 7682343 YP_002738938.1 CDS SPP_1837 NC_012467.1 1707352 1709103 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein complement(1707352..1709103) Streptococcus pneumoniae P1031 7681484 YP_002738939.1 CDS SPP_1838 NC_012467.1 1709093 1710838 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein complement(1709093..1710838) Streptococcus pneumoniae P1031 7681443 YP_002738940.1 CDS SPP_1839 NC_012467.1 1710884 1710997 D identified by glimmer; putative; hypothetical protein 1710884..1710997 Streptococcus pneumoniae P1031 7681143 YP_002738941.1 CDS SPP_1840 NC_012467.1 1711044 1711340 R identified by glimmer; putative; hypothetical protein complement(1711044..1711340) Streptococcus pneumoniae P1031 7682215 YP_002738942.1 CDS SPP_1841 NC_012467.1 1711493 1711768 R identified by glimmer; putative; hypothetical protein complement(1711493..1711768) Streptococcus pneumoniae P1031 7681403 YP_002738943.1 CDS SPP_1842 NC_012467.1 1711722 1711949 R identified by glimmer; putative; hypothetical protein complement(1711722..1711949) Streptococcus pneumoniae P1031 7682335 YP_002738944.1 CDS xth NC_012467.1 1712082 1712909 D identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633; exodeoxyribonuclease III 1712082..1712909 Streptococcus pneumoniae P1031 7681346 YP_002738945.1 CDS xpt NC_012467.1 1714181 1714762 D Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 1714181..1714762 Streptococcus pneumoniae P1031 7681598 YP_002738946.1 CDS SPP_1847 NC_012467.1 1714762 1716024 D identified by match to protein family HMM PF00860; match to protein family HMM PF00916; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173; xanthine permease 1714762..1716024 Streptococcus pneumoniae P1031 7682168 YP_002738947.1 CDS SPP_1848 NC_012467.1 1716111 1716977 R identified by match to protein family HMM PF04556; type II restriction enzyme complement(1716111..1716977) Streptococcus pneumoniae P1031 7681503 YP_002738948.1 CDS SPP_1849 NC_012467.1 1716964 1717734 R identified by match to protein family HMM PF01555; DNA methylase complement(1716964..1717734) Streptococcus pneumoniae P1031 7682687 YP_002738949.1 CDS SPP_1850 NC_012467.1 1717760 1718614 R identified by match to protein family HMM PF02086; match to protein family HMM TIGR00571; modification methylase complement(1717760..1718614) Streptococcus pneumoniae P1031 7682059 YP_002738950.1 CDS SPP_1851 NC_012467.1 1718771 1719175 R identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; thioesterase family protein complement(1718771..1719175) Streptococcus pneumoniae P1031 7680930 YP_002738951.1 CDS galT NC_012467.1 1719245 1720726 R catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase complement(1719245..1720726) Streptococcus pneumoniae P1031 7681641 YP_002738952.1 CDS galK NC_012467.1 1720745 1721923 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(1720745..1721923) Streptococcus pneumoniae P1031 7681858 YP_002738953.1 CDS SPP_1854 NC_012467.1 1722087 1723094 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; GalR, member of GalR-LacI family of transcriptional regulators, binds DNA; regulator of gal operon 1722087..1723094 Streptococcus pneumoniae P1031 7682131 YP_002738954.1 CDS SPP_1855 NC_012467.1 1723140 1724177 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; alcohol dehydrogenase, zinc-containing complement(1723140..1724177) Streptococcus pneumoniae P1031 7681556 YP_002738955.1 CDS SPP_1856 NC_012467.1 1724178 1724531 R identified by match to protein family HMM PF00376; transcriptional regulator, MerR family complement(1724178..1724531) Streptococcus pneumoniae P1031 7682257 YP_002738956.1 CDS SPP_1857 NC_012467.1 1724775 1725665 R identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation diffusion facilitator transporter - heavy metal transport complement(1724775..1725665) Streptococcus pneumoniae P1031 7681934 YP_002738957.1 CDS SPP_1858 NC_012467.1 1725798 1726334 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 1725798..1726334 Streptococcus pneumoniae P1031 7681462 YP_002738958.1 CDS SPP_1859 NC_012467.1 1726500 1727306 R identified by match to protein family HMM PF04973; match to protein family HMM TIGR01528; nicotinamide mononucleotide transporter complement(1726500..1727306) Streptococcus pneumoniae P1031 7682234 YP_002738959.1 CDS SPP_1860 NC_012467.1 1727830 1729176 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; identified by match to protein family HMM PF01609; Spn1 transposase complement(1727830..1729176) Streptococcus pneumoniae P1031 7681348 YP_002738960.1 CDS SPP_1861 NC_012467.1 1729359 1730879 R identified by match to protein family HMM PF00528; match to protein family HMM PF04069; choline ABC transporter permease complement(1729359..1730879) Streptococcus pneumoniae P1031 7681351 YP_002738961.1 CDS SPP_1862 NC_012467.1 1730872 1731600 R identified by match to protein family HMM PF00005; choline transport ATP-binding protein opuBA complement(1730872..1731600) Streptococcus pneumoniae P1031 7681819 YP_002738962.1 CDS SPP_1863 NC_012467.1 1731615 1732379 R identified by match to protein family HMM PF07366; hypothetical protein complement(1731615..1732379) Streptococcus pneumoniae P1031 7681317 YP_002738963.1 CDS SPP_1864 NC_012467.1 1732383 1732826 R identified by match to protein family HMM PF01047; transcriptional regulator, MarR family complement(1732383..1732826) Streptococcus pneumoniae P1031 7682697 YP_002738964.1 CDS SPP_1865 NC_012467.1 1733508 1733804 R identified by match to protein family HMM PF08957; hypothetical protein complement(1733508..1733804) Streptococcus pneumoniae P1031 7680970 YP_002738965.1 CDS pepA NC_012467.1 1733826 1734890 R identified by match to protein family HMM PF05343; match to protein family HMM TIGR03107; glutamyl aminopeptidase complement(1733826..1734890) Streptococcus pneumoniae P1031 7681050 YP_002738966.1 CDS SPP_1867 NC_012467.1 1735046 1735204 R identified by glimmer; putative; hypothetical protein complement(1735046..1735204) Streptococcus pneumoniae P1031 7681836 YP_002738967.1 CDS SPP_1869 NC_012467.1 1736416 1737375 D identified by match to protein family HMM PF01032; Fe3+ ABC transporter permease 1736416..1737375 Streptococcus pneumoniae P1031 7681703 YP_002738968.1 CDS SPP_1870 NC_012467.1 1737365 1738321 D identified by match to protein family HMM PF01032; Fe3+ ABC transporter permease 1737365..1738321 Streptococcus pneumoniae P1031 7682556 YP_002738969.1 CDS SPP_1871 NC_012467.1 1738318 1739070 D identified by match to protein family HMM PF00005; ferrichrome transport ATP-binding protein FhuC 1738318..1739070 Streptococcus pneumoniae P1031 7681205 YP_002738970.1 CDS SPP_1872 NC_012467.1 1739166 1740131 D identified by match to protein family HMM PF01497; iron-compound ABC transporter, iron-compound-binding protein 1739166..1740131 Streptococcus pneumoniae P1031 7681842 YP_002738971.1 CDS SPP_1873 NC_012467.1 1740356 1740598 R identified by match to protein family HMM PF01809; match to protein family HMM TIGR00278; hypothetical protein complement(1740356..1740598) Streptococcus pneumoniae P1031 7682725 YP_002738972.1 CDS rluB NC_012467.1 1740598 1741320 R identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal large subunit pseudouridine synthase B complement(1740598..1741320) Streptococcus pneumoniae P1031 7681363 YP_002738973.1 CDS scpB NC_012467.1 1741307 1741876 R functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B complement(1741307..1741876) Streptococcus pneumoniae P1031 7681497 YP_002738974.1 CDS scpA NC_012467.1 1741895 1742623 R functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A complement(1741895..1742623) Streptococcus pneumoniae P1031 7682425 YP_002738975.1 CDS xerD NC_012467.1 1742623 1743363 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD-like protein complement(1742623..1743363) Streptococcus pneumoniae P1031 7681715 YP_002738976.1 CDS SPP_1878 NC_012467.1 1743354 1743815 R identified by match to protein family HMM PF00571; CBS domain protein complement(1743354..1743815) Streptococcus pneumoniae P1031 7682594 YP_002738977.1 CDS SPP_1879 NC_012467.1 1743812 1744333 R identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040; phosphodiesterase, family complement(1743812..1744333) Streptococcus pneumoniae P1031 7681115 YP_002738978.1 CDS SPP_1880 NC_012467.1 1744309 1745280 R HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase/hypothetical protein complement(1744309..1745280) Streptococcus pneumoniae P1031 7680624 YP_002738979.1 CDS murI NC_012467.1 1745277 1746071 R converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase complement(1745277..1746071) Streptococcus pneumoniae P1031 7680628 YP_002738980.1 CDS SPP_1882 NC_012467.1 1746278 1746526 R identified by match to protein family HMM PF03672; hypothetical protein complement(1746278..1746526) Streptococcus pneumoniae P1031 7682761 YP_002738981.1 CDS treC NC_012467.1 1746668 1748293 R identified by match to protein family HMM PF00128; match to protein family HMM TIGR02403; alpha,alpha-phosphotrehalase complement(1746668..1748293) Streptococcus pneumoniae P1031 7681871 YP_002738982.1 CDS treP NC_012467.1 1748471 1750438 R identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01992; pts system, trehalose-specific iibc component complement(1748471..1750438) Streptococcus pneumoniae P1031 7682084 YP_002738983.1 CDS treR NC_012467.1 1750623 1751333 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM TIGR02404; trehalose operon repressor 1750623..1751333 Streptococcus pneumoniae P1031 7681283 YP_002738984.1 CDS SPP_1886 NC_012467.1 1751366 1752169 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1751366..1752169) Streptococcus pneumoniae P1031 7681947 YP_002738985.1 CDS SPP_1891 NC_012467.1 1753974 1754102 D identified by glimmer; putative; hypothetical protein 1753974..1754102 Streptococcus pneumoniae P1031 7682605 YP_002738986.1 CDS SPP_1892 NC_012467.1 1754500 1755426 R identified by match to protein family HMM PF00005; match to protein family HMM PF08352; oligopeptide transport ATP-binding protein AmiF complement(1754500..1755426) Streptococcus pneumoniae P1031 7680841 YP_002738987.1 CDS SPP_1893 NC_012467.1 1755437 1756504 R identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; oligopeptide transport ATP-binding protein OppD complement(1755437..1756504) Streptococcus pneumoniae P1031 7682671 YP_002738988.1 CDS SPP_1894 NC_012467.1 1756513 1757439 R identified by match to protein family HMM PF00528; oligopeptide transport system permease protein AmiD complement(1756513..1757439) Streptococcus pneumoniae P1031 7682688 YP_002738989.1 CDS SPP_1895 NC_012467.1 1757439 1758935 R identified by match to protein family HMM PF00528; oligopeptide transport system permease protein AmiC complement(1757439..1758935) Streptococcus pneumoniae P1031 7680987 YP_002738990.1 CDS SPP_1896 NC_012467.1 1759002 1760981 R identified by match to protein family HMM PF00496; AmiA protein complement(1759002..1760981) Streptococcus pneumoniae P1031 7682163 YP_002738991.1 CDS SPP_1897 NC_012467.1 1761109 1761276 D hypothetical protein 1761109..1761276 Streptococcus pneumoniae P1031 7681086 YP_002738992.1 CDS SPP_1898 NC_012467.1 1761668 1762861 R identified by match to protein family HMM PF04932; O-antigen polymerase family complement(1761668..1762861) Streptococcus pneumoniae P1031 7681806 YP_002738993.1 CDS SPP_1899 NC_012467.1 1762999 1764441 R identified by match to protein family HMM PF00128; sucrose phosphorylase (Sucrose glucosyltransferase)(Glucosyltransferase-A) (GTF-A) complement(1762999..1764441) Streptococcus pneumoniae P1031 7681065 YP_002738994.1 CDS SPP_1900 NC_012467.1 1764625 1764792 R hypothetical protein complement(1764625..1764792) Streptococcus pneumoniae P1031 7682669 YP_002738995.1 CDS SPP_1901 NC_012467.1 1764799 1765632 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1764799..1765632) Streptococcus pneumoniae P1031 7681643 YP_002738996.1 CDS SPP_1902 NC_012467.1 1765646 1766512 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1765646..1766512) Streptococcus pneumoniae P1031 7680974 YP_002738997.1 CDS SPP_1903 NC_012467.1 1766526 1767785 R identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein complement(1766526..1767785) Streptococcus pneumoniae P1031 7681093 YP_002738998.1 CDS SPP_1904 NC_012467.1 1767877 1770039 R identified by match to protein family HMM PF02065; alpha-galactosidase AgaN complement(1767877..1770039) Streptococcus pneumoniae P1031 7680795 YP_002738999.1 CDS SPP_1905 NC_012467.1 1770147 1771007 D identified by match to protein family HMM PF00165; match to protein family HMM PF02311; Msm operon regulatory protein 1770147..1771007 Streptococcus pneumoniae P1031 7682483 YP_002739000.1 CDS SPP_1906 NC_012467.1 1771004 1771939 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1771004..1771939 Streptococcus pneumoniae P1031 7681695 YP_002739001.1 CDS rumA2 NC_012467.1 1778843 1780198 R identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA complement(1778843..1780198) Streptococcus pneumoniae P1031 7680736 YP_002739002.1 CDS SPP_1930 NC_012467.1 1780168 1781031 D identified by match to protein family HMM PF01636; aminoglycoside phosphotransferase 1780168..1781031 Streptococcus pneumoniae P1031 7681652 YP_002739003.1 CDS recX NC_012467.1 1781041 1781817 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1781041..1781817 Streptococcus pneumoniae P1031 7682394 YP_002739004.1 CDS SPP_1932 NC_012467.1 1781906 1782439 D identified by match to protein family HMM PF04167; hypothetical protein 1781906..1782439 Streptococcus pneumoniae P1031 7682357 YP_002739005.1 CDS groEL NC_012467.1 1783773 1785395 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL complement(1783773..1785395) Streptococcus pneumoniae P1031 7680697 YP_002739006.1 CDS groES NC_012467.1 1785411 1785695 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(1785411..1785695) Streptococcus pneumoniae P1031 7682767 YP_002739007.1 CDS SPP_1937 NC_012467.1 1785965 1786360 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1785965..1786360) Streptococcus pneumoniae P1031 7681458 YP_002739008.1 CDS SPP_1938 NC_012467.1 1786438 1787199 R identified by match to protein family HMM PF00106; match to protein family HMM PF08659; oxidoreductase, short chain dehydrogenase/reductase family complement(1786438..1787199) Streptococcus pneumoniae P1031 7681534 YP_002739009.1 CDS SPP_1939 NC_012467.1 1787232 1787858 R identified by match to protein family HMM PF01588; putative tRNA binding domain protein complement(1787232..1787858) Streptococcus pneumoniae P1031 7680954 YP_002739010.1 CDS SPP_1940 NC_012467.1 1787874 1788191 R identified by match to protein family HMM PF00085; thioredoxin family protein complement(1787874..1788191) Streptococcus pneumoniae P1031 7682003 YP_002739011.1 CDS SPP_1941 NC_012467.1 1788188 1788487 R hypothetical protein complement(1788188..1788487) Streptococcus pneumoniae P1031 7680806 YP_002739012.1 CDS SPP_1942 NC_012467.1 1788772 1788963 R identified by match to protein family HMM PF01473; hypothetical protein complement(1788772..1788963) Streptococcus pneumoniae P1031 7682841 YP_002739013.1 CDS SPP_1943 NC_012467.1 1789124 1789798 R hypothetical protein complement(1789124..1789798) Streptococcus pneumoniae P1031 7681916 YP_002739014.1 CDS SPP_1944 NC_012467.1 1789803 1790249 R identified by match to protein family HMM PF04397; response regulator of the LytR/AlgR family complement(1789803..1790249) Streptococcus pneumoniae P1031 7682808 YP_002739015.1 CDS SPP_1945 NC_012467.1 1790363 1790866 R identified by match to protein family HMM PF01569; PAP2 family protein complement(1790363..1790866) Streptococcus pneumoniae P1031 7682604 YP_002739016.1 CDS SPP_1946 NC_012467.1 1790863 1791225 R hypothetical protein complement(1790863..1791225) Streptococcus pneumoniae P1031 7681144 YP_002739017.1 CDS SPP_1952 NC_012467.1 1793760 1794476 R identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein complement(1793760..1794476) Streptococcus pneumoniae P1031 7681663 YP_002739018.1 CDS SPP_1953 NC_012467.1 1795357 1796772 R identified by match to protein family HMM PF01289; pneumolysin (Thiol-activated cytolysin) complement(1795357..1796772) Streptococcus pneumoniae P1031 7682863 YP_002739019.1 CDS SPP_1954 NC_012467.1 1796783 1797193 R hypothetical protein complement(1796783..1797193) Streptococcus pneumoniae P1031 7682004 YP_002739020.1 CDS SPP_1955 NC_012467.1 1797186 1797794 R hypothetical protein complement(1797186..1797794) Streptococcus pneumoniae P1031 7681041 YP_002739021.1 CDS SPP_1956 NC_012467.1 1797807 1798265 R hypothetical protein complement(1797807..1798265) Streptococcus pneumoniae P1031 7681042 YP_002739022.1 CDS SPP_1957 NC_012467.1 1798390 1798521 D mobile genetic element 1798390..1798521 Streptococcus pneumoniae P1031 7680906 YP_002739023.1 CDS SPP_1958 NC_012467.1 1798526 1798789 D mobile genetic element 1798526..1798789 Streptococcus pneumoniae P1031 7681891 YP_002739024.1 CDS SPP_1959 NC_012467.1 1799554 1799814 R hypothetical protein complement(1799554..1799814) Streptococcus pneumoniae P1031 7681136 YP_002739025.1 CDS SPP_1960 NC_012467.1 1799873 1800424 R hypothetical protein complement(1799873..1800424) Streptococcus pneumoniae P1031 7682274 YP_002739026.1 CDS SPP_1961 NC_012467.1 1800414 1800611 R hypothetical protein complement(1800414..1800611) Streptococcus pneumoniae P1031 7682408 YP_002739027.1 CDS SPP_1962 NC_012467.1 1800615 1801199 R hypothetical protein complement(1800615..1801199) Streptococcus pneumoniae P1031 7682112 YP_002739028.1 CDS SPP_1963 NC_012467.1 1801597 1802022 R hypothetical protein complement(1801597..1802022) Streptococcus pneumoniae P1031 7682222 YP_002739029.1 CDS SPP_1964 NC_012467.1 1802151 1802510 R hypothetical protein complement(1802151..1802510) Streptococcus pneumoniae P1031 7681603 YP_002739030.1 CDS SPP_1965 NC_012467.1 1802749 1802910 R type II restriction-modification system regulatory protein, putative complement(1802749..1802910) Streptococcus pneumoniae P1031 7682700 YP_002739031.1 CDS SPP_1966 NC_012467.1 1803269 1804225 R identified by match to protein family HMM PF01473; match to protein family HMM PF01510; autolysin (N-acetylmuramoyl-L-alanine amidase) (Mureinhydrolase) (Mucopeptide aminohydrolase) (Cell wall hydrolase) complement(1803269..1804225) Streptococcus pneumoniae P1031 7682105 YP_002739032.1 CDS SPP_1967 NC_012467.1 1804601 1805971 R identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; DNA-damage-inducible protein complement(1804601..1805971) Streptococcus pneumoniae P1031 7681707 YP_002739033.1 CDS recA NC_012467.1 1806278 1807444 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(1806278..1807444) Streptococcus pneumoniae P1031 7682326 YP_002739034.1 CDS SPP_1969 NC_012467.1 1807499 1808755 R identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; competence damage-inducible protein A complement(1807499..1808755) Streptococcus pneumoniae P1031 7682678 YP_002739035.1 CDS SPP_1970 NC_012467.1 1808840 1809856 R identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; regulator of lytrabc operon complement(1808840..1809856) Streptococcus pneumoniae P1031 7681026 YP_002739036.1 CDS SPP_1971 NC_012467.1 1809864 1810382 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family complement(1809864..1810382) Streptococcus pneumoniae P1031 7681345 YP_002739037.1 CDS SPP_1972 NC_012467.1 1810372 1810815 R identified by match to protein family HMM PF02367; match to protein family HMM TIGR00150; hypothetical protein complement(1810372..1810815) Streptococcus pneumoniae P1031 7681226 YP_002739038.1 CDS SPP_1973 NC_012467.1 1810901 1811521 R lipoprotein, putative complement(1810901..1811521) Streptococcus pneumoniae P1031 7680650 YP_002739039.1 CDS SPP_1974 NC_012467.1 1811904 1812767 R identified by match to protein family HMM PF01381; transcriptional activator complement(1811904..1812767) Streptococcus pneumoniae P1031 7682650 YP_002739040.1 CDS SPP_1975 NC_012467.1 1812956 1813126 D hypothetical protein 1812956..1813126 Streptococcus pneumoniae P1031 7681957 YP_002739041.1 CDS SPP_1976 NC_012467.1 1813271 1815286 D identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; bacteriocin-associated integral membrane protein 1813271..1815286 Streptococcus pneumoniae P1031 7682495 YP_002739042.1 CDS SPP_1977 NC_012467.1 1815288 1815920 D identified by match to protein family HMM PF00005; antimicrobial peptide ABC transporter ATPase 1815288..1815920 Streptococcus pneumoniae P1031 7681547 YP_002739043.1 CDS SPP_1978 NC_012467.1 1816061 1816339 D hypothetical protein 1816061..1816339 Streptococcus pneumoniae P1031 7681878 YP_002739044.1 CDS ndk NC_012467.1 1816848 1817261 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(1816848..1817261) Streptococcus pneumoniae P1031 7682769 YP_002739045.1 CDS rpoC NC_012467.1 1817372 1821049 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(1817372..1821049) Streptococcus pneumoniae P1031 7682571 YP_002739046.1 CDS rpoB NC_012467.1 1821082 1824693 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(1821082..1824693) Streptococcus pneumoniae P1031 7682759 YP_002739047.1 CDS SPP_1983 NC_012467.1 1825377 1826708 R identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471; CBS domain protein complement(1825377..1826708) Streptococcus pneumoniae P1031 7680756 YP_002739048.1 CDS SPP_1984 NC_012467.1 1826999 1827823 R identified by match to protein family HMM PF01223; DNA-entry nuclease (Competence-specific nuclease) complement(1826999..1827823) Streptococcus pneumoniae P1031 7681761 YP_002739049.1 CDS SPP_1985 NC_012467.1 1827862 1828050 R hypothetical protein complement(1827862..1828050) Streptococcus pneumoniae P1031 7682666 YP_002739050.1 CDS murA2 NC_012467.1 1828043 1829326 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(1828043..1829326) Streptococcus pneumoniae P1031 7681024 YP_002739051.1 CDS SPP_1987 NC_012467.1 1829350 1829481 R hypothetical protein complement(1829350..1829481) Streptococcus pneumoniae P1031 7681665 YP_002739052.1 CDS SPP_1988 NC_012467.1 1829638 1830675 R ATP-dependent protease La complement(1829638..1830675) Streptococcus pneumoniae P1031 7682330 YP_002739053.1 CDS coaD NC_012467.1 1830659 1831147 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(1830659..1831147) Streptococcus pneumoniae P1031 7682294 YP_002739054.1 CDS rsmD NC_012467.1 1831137 1831676 R identified by match to protein family HMM PF03602; match to protein family HMM TIGR00095; RNA methyltransferase, RsmD family complement(1831137..1831676) Streptococcus pneumoniae P1031 7680668 YP_002739055.1 CDS asnA NC_012467.1 1831741 1832733 R catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA complement(1831741..1832733) Streptococcus pneumoniae P1031 7681172 YP_002739056.1 CDS SPP_1992 NC_012467.1 1832707 1832838 D identified by glimmer; putative; hypothetical protein 1832707..1832838 Streptococcus pneumoniae P1031 7682503 YP_002739057.1 CDS SPP_1993 NC_012467.1 1832844 1833527 R identified by match to protein family HMM PF01027; membrane protein complement(1832844..1833527) Streptococcus pneumoniae P1031 7680810 YP_002739058.1 CDS SPP_1994 NC_012467.1 1833583 1834323 R identified by match to protein family HMM PF00588; match to protein family HMM PF08032; rRNA/tRNA methylase complement(1833583..1834323) Streptococcus pneumoniae P1031 7682677 YP_002739059.1 CDS SPP_1995 NC_012467.1 1834357 1834635 D catalyzes the hydrolysis of acylphosphate; acylphosphatase 1834357..1834635 Streptococcus pneumoniae P1031 7681981 YP_002739060.1 CDS SPP_1996 NC_012467.1 1834713 1835639 D involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor 1834713..1835639 Streptococcus pneumoniae P1031 7682497 YP_002739061.1 CDS pflA NC_012467.1 1835714 1836508 R identified by match to protein family HMM PF04055; match to protein family HMM TIGR02493; pyruvate formate-lyase 1-activating enzyme complement(1835714..1836508) Streptococcus pneumoniae P1031 7681853 YP_002739062.1 CDS SPP_1998 NC_012467.1 1836634 1837884 R identified by match to protein family HMM PF00278; match to protein family HMM PF02784; diaminopimelate decarboxylase complement(1836634..1837884) Streptococcus pneumoniae P1031 7682801 YP_002739063.1 CDS purR NC_012467.1 1837951 1838778 R identified by match to protein family HMM PF00156; match to protein family HMM PF09182; match to protein family HMM TIGR01743; pur operon repressor complement(1837951..1838778) Streptococcus pneumoniae P1031 7681724 YP_002739064.1 CDS SPP_2000 NC_012467.1 1839045 1839986 R identified by match to protein family HMM PF01336; match to protein family HMM PF01966; 3'-5' exoribonuclease YhaM complement(1839045..1839986) Streptococcus pneumoniae P1031 7681239 YP_002739065.1 CDS SPP_2001 NC_012467.1 1839976 1841232 R identified by match to protein family HMM PF02646; competence-induced protein Ccs50 complement(1839976..1841232) Streptococcus pneumoniae P1031 7681866 YP_002739066.1 CDS SPP_2002 NC_012467.1 1841234 1841896 R identified by match to protein family HMM PF04263; match to protein family HMM PF04265; match to protein family HMM TIGR01378; thiamine pyrophosphokinase complement(1841234..1841896) Streptococcus pneumoniae P1031 7681649 YP_002739067.1 CDS rpe NC_012467.1 1841859 1842515 R identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163; ribulose-phosphate 3-epimerase complement(1841859..1842515) Streptococcus pneumoniae P1031 7681553 YP_002739068.1 CDS rsgA NC_012467.1 1842526 1843404 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(1842526..1843404) Streptococcus pneumoniae P1031 7681213 YP_002739069.1 CDS SPP_2005 NC_012467.1 1843605 1844003 R identified by glimmer; putative; hypothetical protein complement(1843605..1844003) Streptococcus pneumoniae P1031 7681726 YP_002739070.1 CDS SPP_2006 NC_012467.1 1843997 1844770 R identified by glimmer; putative; hypothetical protein complement(1843997..1844770) Streptococcus pneumoniae P1031 7682293 YP_002739071.1 CDS ksgA NC_012467.1 1845460 1846332 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(1845460..1846332) Streptococcus pneumoniae P1031 7680689 YP_002739072.1 CDS SPP_2008 NC_012467.1 1846583 1846801 R identified by glimmer; putative; hypothetical protein complement(1846583..1846801) Streptococcus pneumoniae P1031 7680836 YP_002739073.1 CDS SPP_2009 NC_012467.1 1846869 1847510 R identified by match to protein family HMM PF00005; antimicrobial peptide ABC transporter ATPase complement(1846869..1847510) Streptococcus pneumoniae P1031 7681410 YP_002739074.1 CDS SPP_2012 NC_012467.1 1849810 1850709 R transcriptional activator complement(1849810..1850709) Streptococcus pneumoniae P1031 7681607 YP_002739075.1 CDS SPP_2013 NC_012467.1 1850781 1851341 R identified by match to protein family HMM PF01751; match to protein family HMM TIGR00334; putative primase homolog complement(1850781..1851341) Streptococcus pneumoniae P1031 7681015 YP_002739076.1 CDS SPP_2014 NC_012467.1 1851341 1852114 R identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010; deoxyribonuclease TatD family complement(1851341..1852114) Streptococcus pneumoniae P1031 7682010 YP_002739077.1 CDS SPP_2015 NC_012467.1 1852419 1853312 R identified by match to protein family HMM PF00746; match to protein family HMM PF07564; match to protein family HMM TIGR01167; cell wall surface anchor family protein complement(1852419..1853312) Streptococcus pneumoniae P1031 7680843 YP_002739078.1 CDS rpmH NC_012467.1 1853596 1853730 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(1853596..1853730) Streptococcus pneumoniae P1031 7680890 YP_002739079.1 CDS SPP_2017 NC_012467.1 1853875 1855089 R broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT complement(1853875..1855089) Streptococcus pneumoniae P1031 7682302 YP_002739080.1 CDS SPP_2018 NC_012467.1 1855245 1855538 R hypothetical protein complement(1855245..1855538) Streptococcus pneumoniae P1031 7682579 YP_002739081.1 CDS SPP_2019 NC_012467.1 1855700 1856152 D identified by match to protein family HMM PF00582; universal stress protein family protein 1855700..1856152 Streptococcus pneumoniae P1031 7681207 YP_002739082.1 CDS SPP_2020 NC_012467.1 1856187 1857575 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1856187..1857575) Streptococcus pneumoniae P1031 7682185 YP_002739083.1 CDS SPP_2022 NC_012467.1 1857641 1858603 D identified by match to protein family HMM PF00710; L-asparaginase 1857641..1858603 Streptococcus pneumoniae P1031 7682282 YP_002739084.1 CDS SPP_2021 NC_012467.1 1858600 1858971 R hypothetical protein complement(1858600..1858971) Streptococcus pneumoniae P1031 7681090 YP_002739085.1 CDS ccpA NC_012467.1 1859035 1860045 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; match to protein family HMM TIGR01481; catabolite control protein A complement(1859035..1860045) Streptococcus pneumoniae P1031 7682073 YP_002739086.1 CDS SPP_2024 NC_012467.1 1860470 1861069 R identified by match to protein family HMM PF00072; match to protein family HMM PF00196; response regulator complement(1860470..1861069) Streptococcus pneumoniae P1031 7681028 YP_002739087.1 CDS SPP_2025 NC_012467.1 1861071 1862168 R identified by match to protein family HMM PF02518; match to protein family HMM PF07730; histidine kinase complement(1861071..1862168) Streptococcus pneumoniae P1031 7682251 YP_002739088.1 CDS SPP_2026 NC_012467.1 1862168 1862905 R identified by match to protein family HMM PF01061; multidrug ABC transporter permease complement(1862168..1862905) Streptococcus pneumoniae P1031 7681670 YP_002739089.1 CDS SPP_2027 NC_012467.1 1862907 1863791 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1862907..1863791) Streptococcus pneumoniae P1031 7680798 YP_002739090.1 CDS SPP_2028 NC_012467.1 1863778 1863972 R hypothetical protein complement(1863778..1863972) Streptococcus pneumoniae P1031 7682633 YP_002739091.1 CDS SPP_2029 NC_012467.1 1863969 1864175 R hypothetical protein complement(1863969..1864175) Streptococcus pneumoniae P1031 7680988 YP_002739092.1 CDS SPP_2044 NC_012467.1 1870856 1871335 R competence-specific global transcription modulator complement(1870856..1871335) Streptococcus pneumoniae P1031 7680754 YP_002739093.1 CDS nusG NC_012467.1 1871457 1871993 R Modulates Rho-dependent transcription termination; transcription antitermination protein NusG complement(1871457..1871993) Streptococcus pneumoniae P1031 7682777 YP_002739094.1 CDS secE NC_012467.1 1872048 1872224 R forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(1872048..1872224) Streptococcus pneumoniae P1031 7682435 YP_002739095.1 CDS rpmG NC_012467.1 1872234 1872386 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 complement(1872234..1872386) Streptococcus pneumoniae P1031 7682350 YP_002739096.1 CDS SPP_2048 NC_012467.1 1872439 1874634 R identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 2A complement(1872439..1874634) Streptococcus pneumoniae P1031 7682028 YP_002739097.1 CDS SPP_2049 NC_012467.1 1874760 1875596 D identified by match to protein family HMM PF00849; ribosomal large subunit pseudouridine synthase, RluD subfamily 1874760..1875596 Streptococcus pneumoniae P1031 7681664 YP_002739098.1 CDS gap NC_012467.1 1875663 1876670 R identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; glyceraldehyde-3-phosphate dehydrogenase, type I complement(1875663..1876670) Streptococcus pneumoniae P1031 7682114 YP_002739099.1 CDS SPP_2051 NC_012467.1 1876848 1877810 R identified by match to protein family HMM PF02687; efflux ABC transporter, permease protein complement(1876848..1877810) Streptococcus pneumoniae P1031 7681080 YP_002739100.1 CDS SPP_2052 NC_012467.1 1877833 1877961 R identified by glimmer; putative; hypothetical protein complement(1877833..1877961) Streptococcus pneumoniae P1031 7681618 YP_002739101.1 CDS SPP_2053 NC_012467.1 1878368 1878718 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01710; transposase complement(1878368..1878718) Streptococcus pneumoniae P1031 7682362 YP_002739102.1 CDS nadC NC_012467.1 1878849 1879721 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase complement(1878849..1879721) Streptococcus pneumoniae P1031 7681386 YP_002739103.1 CDS SPP_2055 NC_012467.1 1879958 1881268 D identified by match to protein family HMM PF03600; match to protein family HMM PF07158; membrane protein 1879958..1881268 Streptococcus pneumoniae P1031 7681327 YP_002739104.1 CDS SPP_2056 NC_012467.1 1881633 1881764 R hypothetical protein complement(1881633..1881764) Streptococcus pneumoniae P1031 7682631 YP_002739105.1 CDS SPP_2057 NC_012467.1 1882286 1883014 R identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator complement(1882286..1883014) Streptococcus pneumoniae P1031 7681274 YP_002739106.1 CDS SPP_2058 NC_012467.1 1883172 1884581 D identified by match to protein family HMM PF00232; glycosyl hydrolase, family protein 1 1883172..1884581 Streptococcus pneumoniae P1031 7682729 YP_002739107.1 CDS SPP_2059 NC_012467.1 1884599 1885894 D identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; phosphotransferase system system, cellobiose-specific IIC component 1884599..1885894 Streptococcus pneumoniae P1031 7681897 YP_002739108.1 CDS SPP_2060 NC_012467.1 1885899 1886207 D identified by match to protein family HMM PF02302; lichenan-specific phosphotransferase enzyme iib component (pts system lichenan-specific eiib component) (eiib-lic) 1885899..1886207 Streptococcus pneumoniae P1031 7680846 YP_002739109.1 CDS SPP_2061 NC_012467.1 1886204 1886512 D identified by match to protein family HMM PF02255; lichenan-specific phosphotransferase enzyme iia component (pts system lichenan-specific eiia component) (eiia-lic) (eiii-lic) 1886204..1886512 Streptococcus pneumoniae P1031 7681751 YP_002739110.1 CDS SPP_2062 NC_012467.1 1887420 1890071 R identified by match to protein family HMM PF00465; bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1887420..1890071) Streptococcus pneumoniae P1031 7680981 YP_002739111.1 CDS SPP_2063 NC_012467.1 1890370 1890780 R identified by match to protein family HMM PF02493; morn motif family protein complement(1890370..1890780) Streptococcus pneumoniae P1031 7681459 YP_002739112.1 CDS SPP_2064 NC_012467.1 1890782 1891210 R identified by match to protein family HMM PF01451; phosphotyrosine protein phosphatase complement(1890782..1891210) Streptococcus pneumoniae P1031 7681320 YP_002739113.1 CDS yajC NC_012467.1 1891256 1891555 R member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC complement(1891256..1891555) Streptococcus pneumoniae P1031 7681807 YP_002739114.1 CDS tkt2 NC_012467.1 1891672 1893648 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(1891672..1893648) Streptococcus pneumoniae P1031 7681675 YP_002739115.1 CDS SPP_2067 NC_012467.1 1893762 1894853 R putative L-ascorbate 6-phosphate lactonase complement(1893762..1894853) Streptococcus pneumoniae P1031 7680833 YP_002739116.1 CDS SPP_2068 NC_012467.1 1894965 1896638 R identified by match to protein family HMM PF00874; match to protein family HMM PF08279; transcriptional regulator, BglG family complement(1894965..1896638) Streptococcus pneumoniae P1031 7682814 YP_002739117.1 CDS araD NC_012467.1 1896817 1897521 R catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase complement(1896817..1897521) Streptococcus pneumoniae P1031 7682602 YP_002739118.1 CDS SPP_2070 NC_012467.1 1897523 1898386 R L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase complement(1897523..1898386) Streptococcus pneumoniae P1031 7682162 YP_002739119.1 CDS ulaD NC_012467.1 1898390 1899055 R catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase complement(1898390..1899055) Streptococcus pneumoniae P1031 7681147 YP_002739120.1 CDS SPP_2072 NC_012467.1 1899072 1899557 R identified by match to protein family HMM PF00359; ascorbate-specific phosphotransferase enzyme iia component (pts system ascorbate-specific eiia component) complement(1899072..1899557) Streptococcus pneumoniae P1031 7681032 YP_002739121.1 CDS SPP_2073 NC_012467.1 1899634 1899915 R identified by match to protein family HMM PF02302; ascorbate-specific phosphotransferase enzyme iib component (ascorbate-specific pts system eiib component) complement(1899634..1899915) Streptococcus pneumoniae P1031 7682018 YP_002739122.1 CDS SPP_2074 NC_012467.1 1899938 1901395 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(1899938..1901395) Streptococcus pneumoniae P1031 7682331 YP_002739123.1 CDS SPP_2075 NC_012467.1 1901526 1902149 R hypothetical protein complement(1901526..1902149) Streptococcus pneumoniae P1031 7681739 YP_002739124.1 CDS SPP_2076 NC_012467.1 1902200 1903186 R identified by match to protein family HMM PF01424; jag protein complement(1902200..1903186) Streptococcus pneumoniae P1031 7681173 YP_002739125.1 CDS SPP_2077 NC_012467.1 1903205 1904035 R identified by match to protein family HMM PF02096; match to protein family HMM TIGR03592; membrane protein OxaA 1 complement(1903205..1904035) Streptococcus pneumoniae P1031 7681620 YP_002739126.1 CDS rnpA NC_012467.1 1904004 1904375 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(1904004..1904375) Streptococcus pneumoniae P1031 7682539 YP_002739127.1 CDS SPP_2079 NC_012467.1 1904392 1904523 R hypothetical protein complement(1904392..1904523) Streptococcus pneumoniae P1031 7681070 YP_002739128.1 CDS ackA NC_012467.1 1904524 1905714 R AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase complement(1904524..1905714) Streptococcus pneumoniae P1031 7682436 YP_002739129.1 CDS SPP_2081 NC_012467.1 1905765 1906718 R adenine-specific DNA methylase complement(1905765..1906718) Streptococcus pneumoniae P1031 7681968 YP_002739130.1 CDS SPP_2082 NC_012467.1 1906787 1906936 D identified by glimmer; putative; hypothetical protein 1906787..1906936 Streptococcus pneumoniae P1031 7681357 YP_002739131.1 CDS SPP_2083 NC_012467.1 1906977 1907159 R identified by glimmer; putative; hypothetical protein complement(1906977..1907159) Streptococcus pneumoniae P1031 7680777 YP_002739132.1 CDS SPP_2085 NC_012467.1 1907510 1907923 R hypothetical protein complement(1907510..1907923) Streptococcus pneumoniae P1031 7680673 YP_002739133.1 CDS SPP_2086 NC_012467.1 1907901 1908362 R competence protein ComGF complement(1907901..1908362) Streptococcus pneumoniae P1031 7682247 YP_002739134.1 CDS SPP_2087 NC_012467.1 1908325 1908585 R hypothetical protein complement(1908325..1908585) Streptococcus pneumoniae P1031 7680962 YP_002739135.1 CDS SPP_2088 NC_012467.1 1908590 1908994 R identified by match to protein family HMM TIGR02532; competence protein CglD complement(1908590..1908994) Streptococcus pneumoniae P1031 7680865 YP_002739136.1 CDS SPP_2089 NC_012467.1 1908987 1909313 R identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532; competence protein CglC complement(1908987..1909313) Streptococcus pneumoniae P1031 7680801 YP_002739137.1 CDS SPP_2090 NC_012467.1 1909315 1910163 R identified by match to protein family HMM PF00482; competence protein CglB complement(1909315..1910163) Streptococcus pneumoniae P1031 7682642 YP_002739138.1 CDS SPP_2091 NC_012467.1 1910279 1911220 R identified by match to protein family HMM PF00437; putative ABC transporter subunit ComYA complement(1910279..1911220) Streptococcus pneumoniae P1031 7682860 YP_002739139.1 CDS SPP_2092 NC_012467.1 1911296 1911661 R identified by match to protein family HMM PF06279; hypothetical protein complement(1911296..1911661) Streptococcus pneumoniae P1031 7682207 YP_002739140.1 CDS SPP_2093 NC_012467.1 1911812 1912870 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; alcohol dehydrogenase, zinc-containing complement(1911812..1912870) Streptococcus pneumoniae P1031 7681149 YP_002739141.1 CDS nagA NC_012467.1 1913033 1914184 R identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221; N-acetylglucosamine-6-phosphate deacetylase complement(1913033..1914184) Streptococcus pneumoniae P1031 7681476 YP_002739142.1 CDS SPP_2095 NC_012467.1 1914337 1916154 R identified by match to protein family HMM PF01757; acyltransferase complement(1914337..1916154) Streptococcus pneumoniae P1031 7680984 YP_002739143.1 CDS tgt NC_012467.1 1916255 1917397 R Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase complement(1916255..1917397) Streptococcus pneumoniae P1031 7681802 YP_002739144.1 CDS SPP_2097 NC_012467.1 1917527 1918384 D identified by match to protein family HMM PF06161; hypothetical protein 1917527..1918384 Streptococcus pneumoniae P1031 7681765 YP_002739145.1 CDS pcp2 NC_012467.1 1918412 1919056 R catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase complement(1918412..1919056) Streptococcus pneumoniae P1031 7681520 YP_002739146.1 CDS SPP_2099 NC_012467.1 1919163 1919531 R identified by match to protein family HMM PF06993; hypothetical protein complement(1919163..1919531) Streptococcus pneumoniae P1031 7681895 YP_002739147.1 CDS SPP_2102 NC_012467.1 1920285 1920407 D identified by glimmer; putative; hypothetical protein 1920285..1920407 Streptococcus pneumoniae P1031 7681841 YP_002739148.1 CDS SPP_2101 NC_012467.1 1920393 1921571 R identified by match to protein family HMM PF01476; LysM domain-containing protein complement(1920393..1921571) Streptococcus pneumoniae P1031 7681960 YP_002739149.1 CDS SPP_2103 NC_012467.1 1921737 1922357 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; HAD-superfamily hydrolase, subfamily IA, variant 1 complement(1921737..1922357) Streptococcus pneumoniae P1031 7682780 YP_002739150.1 CDS SPP_2104 NC_012467.1 1922361 1923641 R identified by match to protein family HMM PF01554; match to protein family HMM PF03023; match to protein family HMM TIGR00797; multi antimicrobial extrusion complement(1922361..1923641) Streptococcus pneumoniae P1031 7681220 YP_002739151.1 CDS thrC NC_012467.1 1923702 1925186 R catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase complement(1923702..1925186) Streptococcus pneumoniae P1031 7681549 YP_002739152.1 CDS SPP_2106 NC_012467.1 1925262 1926539 R hypothetical protein complement(1925262..1926539) Streptococcus pneumoniae P1031 7682465 YP_002739153.1 CDS SPP_2123 NC_012467.1 1933008 1933442 R cytidine/deoxycytidylate deaminase family protein complement(1933008..1933442) Streptococcus pneumoniae P1031 7680741 YP_002739154.1 CDS gltX NC_012467.1 1933456 1934916 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(1933456..1934916) Streptococcus pneumoniae P1031 7680905 YP_002739155.1 CDS pgi NC_012467.1 1935040 1936389 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(1935040..1936389) Streptococcus pneumoniae P1031 7681049 YP_002739156.1 CDS SPP_2126 NC_012467.1 1936376 1936555 R hypothetical protein complement(1936376..1936555) Streptococcus pneumoniae P1031 7681413 YP_002739157.1 CDS SPP_2127 NC_012467.1 1936559 1937248 R identified by match to protein family HMM PF00117; match to protein family HMM PF07722; glutamine amidotransferase complement(1936559..1937248) Streptococcus pneumoniae P1031 7681546 YP_002739158.1 CDS SPP_2128 NC_012467.1 1937387 1939153 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease complement(1937387..1939153) Streptococcus pneumoniae P1031 7682026 YP_002739159.1 CDS SPP_2129 NC_012467.1 1939291 1939614 D transposase 1939291..1939614 Streptococcus pneumoniae P1031 7681012 YP_002739160.1 CDS SPP_2130 NC_012467.1 1939944 1941638 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease complement(1939944..1941638) Streptococcus pneumoniae P1031 7682353 YP_002739161.1 CDS mutS NC_012467.1 1941785 1944319 R This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS complement(1941785..1944319) Streptococcus pneumoniae P1031 7680932 YP_002739162.1 CDS argR NC_012467.1 1944370 1944816 R identified by match to protein family HMM PF01316; match to protein family HMM PF02863; match to protein family HMM TIGR01529; arginine repressor complement(1944370..1944816) Streptococcus pneumoniae P1031 7680706 YP_002739163.1 CDS argS NC_012467.1 1944952 1946643 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1944952..1946643 Streptococcus pneumoniae P1031 7681991 YP_002739164.1 CDS SPP_2134 NC_012467.1 1946958 1947422 R identified by match to protein family HMM PF01609; transposase (IS4 family) complement(1946958..1947422) Streptococcus pneumoniae P1031 7682554 YP_002739165.1 CDS SPP_2135 NC_012467.1 1947502 1947987 D identified by match to protein family HMM PF06172; hypothetical protein 1947502..1947987 Streptococcus pneumoniae P1031 7682820 YP_002739166.1 CDS SPP_2136 NC_012467.1 1948071 1948778 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; alkaline phosphatase synthesis transcriptional regulatory proteinphoP 1948071..1948778 Streptococcus pneumoniae P1031 7681535 YP_002739167.1 CDS SPP_2137 NC_012467.1 1948779 1950110 D identified by match to protein family HMM PF00512; match to protein family HMM PF02518; histidine kinase PnpS 1948779..1950110 Streptococcus pneumoniae P1031 7681397 YP_002739168.1 CDS SPP_2139 NC_012467.1 1950277 1951152 D ABC transporter substrate-binding protein - phosphate transport 1950277..1951152 Streptococcus pneumoniae P1031 7681943 YP_002739169.1 CDS SPP_2138 NC_012467.1 1951145 1951276 R identified by glimmer; putative; hypothetical protein complement(1951145..1951276) Streptococcus pneumoniae P1031 7682665 YP_002739170.1 CDS pstC2 NC_012467.1 1951270 1952133 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease 1951270..1952133 Streptococcus pneumoniae P1031 7682676 YP_002739171.1 CDS pstA2 NC_012467.1 1952126 1952941 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease 1952126..1952941 Streptococcus pneumoniae P1031 7681291 YP_002739172.1 CDS pstB3 NC_012467.1 1952943 1953695 D ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1952943..1953695 Streptococcus pneumoniae P1031 7681701 YP_002739173.1 CDS phoU2 NC_012467.1 1953710 1954360 D identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU 1953710..1954360 Streptococcus pneumoniae P1031 7682281 YP_002739174.1 CDS SPP_2144 NC_012467.1 1954428 1954853 D transposase, IS1380-Spn1 related, truncation 1954428..1954853 Streptococcus pneumoniae P1031 7680785 YP_002739175.1 CDS gpsA NC_012467.1 1955619 1956635 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1955619..1956635 Streptococcus pneumoniae P1031 7681818 YP_002739176.1 CDS galU NC_012467.1 1956657 1957556 D identified by match to protein family HMM PF00483; match to protein family HMM TIGR01099; UTP-glucose-1-phosphate uridylyltransferase 1956657..1957556 Streptococcus pneumoniae P1031 7680939 YP_002739177.1 CDS SPP_2148 NC_012467.1 1957974 1958906 D identified by glimmer; putative; hypothetical protein 1957974..1958906 Streptococcus pneumoniae P1031 7681442 YP_002739178.1 CDS SPP_2149 NC_012467.1 1959009 1959686 R identified by match to protein family HMM PF01694; peptidase, S54 complement(1959009..1959686) Streptococcus pneumoniae P1031 7681140 YP_002739179.1 CDS SPP_2150 NC_012467.1 1959670 1960209 R identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; 5-formyltetrahydrofolate cyclo-ligase complement(1959670..1960209) Streptococcus pneumoniae P1031 7682501 YP_002739180.1 CDS SPP_2151 NC_012467.1 1960221 1961351 R identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01891; peptidase, M20/M25/M40 family complement(1960221..1961351) Streptococcus pneumoniae P1031 7681008 YP_002739181.1 CDS SPP_2152 NC_012467.1 1961419 1962117 R identified by match to protein family HMM PF00132; match to protein family HMM PF08503; galactoside O-acetyltransferase complement(1961419..1962117) Streptococcus pneumoniae P1031 7682199 YP_002739182.1 CDS SPP_2153 NC_012467.1 1962347 1963309 R identified by match to protein family HMM PF00892; membrane protein complement(1962347..1963309) Streptococcus pneumoniae P1031 7681622 YP_002739183.1 CDS SPP_2154 NC_012467.1 1963323 1965788 R identified by match to protein family HMM PF00905; match to protein family HMM PF00912; penicillin-binding protein 1B complement(1963323..1965788) Streptococcus pneumoniae P1031 7681315 YP_002739184.1 CDS tyrS NC_012467.1 1965930 1967186 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1965930..1967186 Streptococcus pneumoniae P1031 7681791 YP_002739185.1 CDS SPP_2156 NC_012467.1 1967264 1969327 R identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01525; P-type ATPase-metal/cation transport complement(1967264..1969327) Streptococcus pneumoniae P1031 7680640 YP_002739186.1 CDS SPP_2157 NC_012467.1 1969329 1969607 R hypothetical protein complement(1969329..1969607) Streptococcus pneumoniae P1031 7681557 YP_002739187.1 CDS SPP_2158 NC_012467.1 1969759 1970607 D identified by match to protein family HMM PF08241; 23S rRNA m1G745 methyltransferase 1969759..1970607 Streptococcus pneumoniae P1031 7681721 YP_002739188.1 CDS SPP_2159 NC_012467.1 1971229 1971801 D hypothetical protein 1971229..1971801 Streptococcus pneumoniae P1031 7682781 YP_002739189.1 CDS SPP_2160 NC_012467.1 1972845 1975103 R identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093; glycogen phosphorylase complement(1972845..1975103) Streptococcus pneumoniae P1031 7681998 YP_002739190.1 CDS malQ NC_012467.1 1975129 1976646 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(1975129..1976646) Streptococcus pneumoniae P1031 7682649 YP_002739191.1 CDS SPP_2162 NC_012467.1 1977196 1978467 D identified by match to protein family HMM PF01547; maltose/maltodextrin-binding protein 1977196..1978467 Streptococcus pneumoniae P1031 7681113 YP_002739192.1 CDS SPP_2163 NC_012467.1 1978578 1979870 D identified by match to protein family HMM PF00528; match to protein family HMM PF05154; maltodextrin transport system permease protein MalC 1978578..1979870 Streptococcus pneumoniae P1031 7681056 YP_002739193.1 CDS SPP_2164 NC_012467.1 1979872 1980714 D identified by match to protein family HMM PF00528; maltose/maltodextrin ABC transporter permease 1979872..1980714 Streptococcus pneumoniae P1031 7681394 YP_002739194.1 CDS SPP_2165 NC_012467.1 1980967 1981767 D maltodextrose utilization protein MalA 1980967..1981767 Streptococcus pneumoniae P1031 7680632 YP_002739195.1 CDS SPP_2166 NC_012467.1 1981777 1982763 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; HTH-type transcriptional regulator MalR (Maltose operontranscriptional repressor) 1981777..1982763 Streptococcus pneumoniae P1031 7680831 YP_002739196.1 CDS SPP_2167 NC_012467.1 1982830 1983501 D hypothetical protein 1982830..1983501 Streptococcus pneumoniae P1031 7682826 YP_002739197.1 CDS SPP_2168 NC_012467.1 1983505 1984446 R identified by match to protein family HMM PF02588; YitT family protein complement(1983505..1984446) Streptococcus pneumoniae P1031 7682728 YP_002739198.1 CDS aspS NC_012467.1 1984424 1986187 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(1984424..1986187) Streptococcus pneumoniae P1031 7682403 YP_002739199.1 CDS SPP_2170 NC_012467.1 1986539 1986769 R hypothetical protein complement(1986539..1986769) Streptococcus pneumoniae P1031 7681192 YP_002739200.1 CDS SPP_2171 NC_012467.1 1986787 1987428 R identified by match to protein family HMM PF02517; caax amino protease family complement(1986787..1987428) Streptococcus pneumoniae P1031 7681359 YP_002739201.1 CDS SPP_2172 NC_012467.1 1987440 1988174 R hypothetical protein complement(1987440..1988174) Streptococcus pneumoniae P1031 7680807 YP_002739202.1 CDS SPP_2173 NC_012467.1 1988177 1988374 R hypothetical protein complement(1988177..1988374) Streptococcus pneumoniae P1031 7681956 YP_002739203.1 CDS SPP_2174 NC_012467.1 1988374 1988580 R identified by match to protein family HMM PF01381; hypothetical protein complement(1988374..1988580) Streptococcus pneumoniae P1031 7682479 YP_002739204.1 CDS SPP_2175 NC_012467.1 1988590 1988904 R hypothetical protein complement(1988590..1988904) Streptococcus pneumoniae P1031 7681543 YP_002739205.1 CDS SPP_2176 NC_012467.1 1989057 1989203 R chlorohydrolase complement(1989057..1989203) Streptococcus pneumoniae P1031 7681407 YP_002739206.1 CDS hisS NC_012467.1 1989200 1990489 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(1989200..1990489) Streptococcus pneumoniae P1031 7682165 YP_002739207.1 CDS SPP_2178 NC_012467.1 1990586 1991815 R identified by match to protein family HMM PF07690; transporter, major facilitator family complement(1990586..1991815) Streptococcus pneumoniae P1031 7681508 YP_002739208.1 CDS SPP_2179 NC_012467.1 1992008 1992859 R identified by match to protein family HMM TIGR01716; positive transcriptional regulator of glucosyltransferase and Spp phenotype complement(1992008..1992859) Streptococcus pneumoniae P1031 7681434 YP_002739209.1 CDS SPP_2180 NC_012467.1 1992983 1993324 D identified by match to protein family HMM PF01883; hypothetical protein 1992983..1993324 Streptococcus pneumoniae P1031 7681930 YP_002739210.1 CDS SPP_2181 NC_012467.1 1993388 1993732 D identified by glimmer; putative; hypothetical protein 1993388..1993732 Streptococcus pneumoniae P1031 7682355 YP_002739211.1 CDS ilvD NC_012467.1 1993758 1995461 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(1993758..1995461) Streptococcus pneumoniae P1031 7682829 YP_002739212.1 CDS SPP_2183 NC_012467.1 1995694 1996626 R identified by match to protein family HMM PF02779; match to protein family HMM PF02780; transketolase, C- subunit complement(1995694..1996626) Streptococcus pneumoniae P1031 7681616 YP_002739213.1 CDS SPP_2184 NC_012467.1 1996623 1997480 R identified by match to protein family HMM PF00456; transketolase complement(1996623..1997480) Streptococcus pneumoniae P1031 7681902 YP_002739214.1 CDS ulaA NC_012467.1 1997484 1998830 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(1997484..1998830) Streptococcus pneumoniae P1031 7681387 YP_002739215.1 CDS SPP_2186 NC_012467.1 1998843 1999127 R identified by match to protein family HMM PF02302; phosphotransferase system, galactitol-specific IIB component complement(1998843..1999127) Streptococcus pneumoniae P1031 7680941 YP_002739216.1 CDS SPP_2187 NC_012467.1 1999131 2001161 R identified by match to protein family HMM PF00359; match to protein family HMM PF00874; transcriptional regulator, BglG family protein complement(1999131..2001161) Streptococcus pneumoniae P1031 7681983 YP_002739217.1 CDS SPP_2188 NC_012467.1 2001352 2002359 D identified by match to protein family HMM PF01145; integral membrane protein 2001352..2002359 Streptococcus pneumoniae P1031 7682021 YP_002739218.1 CDS SPP_2189 NC_012467.1 2002362 2002562 D hypothetical protein 2002362..2002562 Streptococcus pneumoniae P1031 7682087 YP_002739219.1 CDS rpmF NC_012467.1 2002714 2002896 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 2002714..2002896 Streptococcus pneumoniae P1031 7682312 YP_002739220.1 CDS rpmG NC_012467.1 2002912 2003061 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 2002912..2003061 Streptococcus pneumoniae P1031 7682236 YP_002739221.1 CDS SPP_2192 NC_012467.1 2003483 2005363 R identified by match to protein family HMM PF00728; N-acetyl-beta-D-glucosaminidase complement(2003483..2005363) Streptococcus pneumoniae P1031 7682567 YP_002739222.1 CDS SPP_2193 NC_012467.1 2005357 2006226 R identified by match to protein family HMM PF00480; ROK family protein complement(2005357..2006226) Streptococcus pneumoniae P1031 7681313 YP_002739223.1 CDS SPP_2194 NC_012467.1 2006310 2008955 R identified by match to protein family HMM PF01074; match to protein family HMM PF07748; glycosyl hydrolase, family 38 complement(2006310..2008955) Streptococcus pneumoniae P1031 7682240 YP_002739224.1 CDS SPP_2195 NC_012467.1 2009046 2010326 R identified by match to protein family HMM PF06824; twin-arginine translocation pathway signal complement(2009046..2010326) Streptococcus pneumoniae P1031 7680949 YP_002739225.1 CDS SPP_2196 NC_012467.1 2010497 2012581 D identified by match to protein family HMM PF07971; match to protein family HMM TIGR01180; antigen, cell wall surface anchor family 2010497..2012581 Streptococcus pneumoniae P1031 7681460 YP_002739226.1 CDS SPP_2197 NC_012467.1 2012621 2014300 R FucA complement(2012621..2014300) Streptococcus pneumoniae P1031 7681154 YP_002739227.1 CDS SPP_2198 NC_012467.1 2014344 2014457 R identified by glimmer; putative; hypothetical protein complement(2014344..2014457) Streptococcus pneumoniae P1031 7682230 YP_002739228.1 CDS arcA NC_012467.1 2015056 2016285 D catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 2015056..2016285 Streptococcus pneumoniae P1031 7681490 YP_002739229.1 CDS argF NC_012467.1 2016343 2017359 D catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 2016343..2017359 Streptococcus pneumoniae P1031 7680665 YP_002739230.1 CDS arcC NC_012467.1 2017524 2018471 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 2017524..2018471 Streptococcus pneumoniae P1031 7681487 YP_002739231.1 CDS SPP_2202 NC_012467.1 2018682 2020193 D identified by match to protein family HMM PF03606; arginine-ornithine antiporter 2018682..2020193 Streptococcus pneumoniae P1031 7682426 YP_002739232.1 CDS SPP_2203 NC_012467.1 2020215 2021546 D identified by match to protein family HMM PF01546; match to protein family HMM TIGR01887; hypothetical protein 2020215..2021546 Streptococcus pneumoniae P1031 7680857 YP_002739233.1 CDS SPP_2205 NC_012467.1 2022229 2022378 R hypothetical protein complement(2022229..2022378) Streptococcus pneumoniae P1031 7682304 YP_002739234.1 CDS SPP_2207 NC_012467.1 2022880 2023779 R identified by match to protein family HMM PF01145; spfh domain/band 7 family complement(2022880..2023779) Streptococcus pneumoniae P1031 7680893 YP_002739235.1 CDS SPP_2208 NC_012467.1 2023909 2025060 R identified by match to protein family HMM PF00465; NAD-dependent methanol dehydrogenase (medh) complement(2023909..2025060) Streptococcus pneumoniae P1031 7682577 YP_002739236.1 CDS fucI NC_012467.1 2025206 2026972 R catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase complement(2025206..2026972) Streptococcus pneumoniae P1031 7682662 YP_002739237.1 CDS SPP_2210 NC_012467.1 2027029 2030145 R identified by match to protein family HMM PF00754; match to protein family HMM PF08306; match to protein family HMM PF08307; glycosyl hydrolase family 98 complement(2027029..2030145) Streptococcus pneumoniae P1031 7680808 YP_002739238.1 CDS SPP_2211 NC_012467.1 2030155 2032449 R large secreted protein complement(2030155..2032449) Streptococcus pneumoniae P1031 7682198 YP_002739239.1 CDS SPP_2212 NC_012467.1 2032508 2033308 R identified by match to protein family HMM PF03613; mannose permease iid component (pts system mannose-specific eiidcomponent) (eiid-man) (eii-m-man) complement(2032508..2033308) Streptococcus pneumoniae P1031 7682364 YP_002739240.1 CDS SPP_2213 NC_012467.1 2033305 2034078 R identified by match to protein family HMM PF03609; phosphotransferase system sugar-specific EII component complement(2033305..2034078) Streptococcus pneumoniae P1031 7681730 YP_002739241.1 CDS SPP_2214 NC_012467.1 2034103 2034573 R identified by match to protein family HMM PF03830; PTS system, IIB component complement(2034103..2034573) Streptococcus pneumoniae P1031 7681255 YP_002739242.1 CDS SPP_2215 NC_012467.1 2034564 2035007 R identified by match to protein family HMM PF03610; PTS system, IIA component complement(2034564..2035007) Streptococcus pneumoniae P1031 7680647 YP_002739243.1 CDS SPP_2216 NC_012467.1 2034988 2035428 R identified by match to protein family HMM PF05025; fucose operon FucU protein complement(2034988..2035428) Streptococcus pneumoniae P1031 7681615 YP_002739244.1 CDS SPP_2217 NC_012467.1 2035440 2036078 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(2035440..2036078) Streptococcus pneumoniae P1031 7680637 YP_002739245.1 CDS SPP_2218 NC_012467.1 2036193 2037596 R identified by match to protein family HMM PF00370; rhamnulokinase (Rhamnulose kinase) complement(2036193..2037596) Streptococcus pneumoniae P1031 7682077 YP_002739246.1 CDS SPP_2219 NC_012467.1 2037772 2038545 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; regulator of fucose operon 2037772..2038545 Streptococcus pneumoniae P1031 7682626 YP_002739247.1 CDS SPP_2220 NC_012467.1 2039707 2041212 R identified by match to protein family HMM PF01297; match to protein family HMM PF09223; zinc-binding lipoprotein AdcA complement(2039707..2041212) Streptococcus pneumoniae P1031 7681972 YP_002739248.1 CDS SPP_2221 NC_012467.1 2041222 2042028 R identified by match to protein family HMM PF00950; zinc ABC transporter permease complement(2041222..2042028) Streptococcus pneumoniae P1031 7680887 YP_002739249.1 CDS SPP_2222 NC_012467.1 2042021 2042725 R identified by match to protein family HMM PF00005; zinc transport system ATP-binding protein AdcC complement(2042021..2042725) Streptococcus pneumoniae P1031 7681711 YP_002739250.1 CDS SPP_2223 NC_012467.1 2042725 2043165 R identified by match to protein family HMM PF01022; match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF01978; match to protein family HMM PF08279; putative transcriptional repressor complement(2042725..2043165) Streptococcus pneumoniae P1031 7682315 YP_002739251.1 CDS SPP_2224 NC_012467.1 2043150 2043287 D hypothetical protein 2043150..2043287 Streptococcus pneumoniae P1031 7680829 YP_002739252.1 CDS SPP_2225 NC_012467.1 2043320 2044588 R identified by match to protein family HMM PF04914; match to protein family HMM PF04915; match to protein family HMM PF04918; D-alanine transfer from undecaprenol-phosphate to the poly complement(2043320..2044588) Streptococcus pneumoniae P1031 7681638 YP_002739253.1 CDS dltC NC_012467.1 2044581 2044820 R D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 complement(2044581..2044820) Streptococcus pneumoniae P1031 7680971 YP_002739254.1 CDS SPP_2227 NC_012467.1 2044834 2046078 R identified by match to protein family HMM PF03062; protein DltB complement(2044834..2046078) Streptococcus pneumoniae P1031 7680631 YP_002739255.1 CDS dltA NC_012467.1 2046075 2047625 R transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 complement(2046075..2047625) Streptococcus pneumoniae P1031 7682790 YP_002739256.1 CDS SPP_2229 NC_012467.1 2047646 2047777 R hypothetical protein complement(2047646..2047777) Streptococcus pneumoniae P1031 7681659 YP_002739257.1 CDS SPP_2230 NC_012467.1 2048091 2049269 R identified by match to protein family HMM PF07690; permease of the major facilitator superfamily complement(2048091..2049269) Streptococcus pneumoniae P1031 7681567 YP_002739258.1 CDS SPP_2231 NC_012467.1 2049725 2051002 R identified by match to protein family HMM PF00078; match to protein family HMM PF08388; GBSi1, group II intron, maturase complement(2049725..2051002) Streptococcus pneumoniae P1031 7680712 YP_002739259.1 CDS SPP_2232 NC_012467.1 2052192 2052383 D identified by glimmer; putative; hypothetical protein 2052192..2052383 Streptococcus pneumoniae P1031 7682413 YP_002739260.1 CDS SPP_2233 NC_012467.1 2052785 2052988 R identified by glimmer; putative; hypothetical protein complement(2052785..2052988) Streptococcus pneumoniae P1031 7681822 YP_002739261.1 CDS SPP_2234 NC_012467.1 2053081 2053206 D identified by glimmer; putative; hypothetical protein 2053081..2053206 Streptococcus pneumoniae P1031 7682865 YP_002739262.1 CDS SPP_2235 NC_012467.1 2053285 2053989 R identified by match to protein family HMM PF00230; match to protein family HMM TIGR00861; glycerol uptake facilitator protein complement(2053285..2053989) Streptococcus pneumoniae P1031 7680934 YP_002739263.1 CDS SPP_2236 NC_012467.1 2054059 2055885 R identified by match to protein family HMM PF01266; alpha-glycerophosphate oxidase (Glycerol-3-phosphateoxidase) (Exported protein 6) complement(2054059..2055885) Streptococcus pneumoniae P1031 7681128 YP_002739264.1 CDS glpK NC_012467.1 2056032 2057540 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(2056032..2057540) Streptococcus pneumoniae P1031 7680924 YP_002739265.1 CDS SPP_2238 NC_012467.1 2057699 2059108 R identified by match to protein family HMM PF05043; M protein trans-acting positive regulator (MGA) complement(2057699..2059108) Streptococcus pneumoniae P1031 7681021 YP_002739266.1 CDS SPP_2239 NC_012467.1 2059117 2059251 R identified by glimmer; putative; hypothetical protein complement(2059117..2059251) Streptococcus pneumoniae P1031 7682668 YP_002739267.1 CDS hslO NC_012467.1 2059291 2060163 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 2059291..2060163 Streptococcus pneumoniae P1031 7681980 YP_002739268.1 CDS SPP_2241 NC_012467.1 2060150 2061130 D identified by match to protein family HMM PF00724; match to protein family HMM PF01180; match to protein family HMM PF01207; match to protein family HMM TIGR00737; tRNA-dihydrouridine synthase B 2060150..2061130 Streptococcus pneumoniae P1031 7681608 YP_002739269.1 CDS SPP_2242 NC_012467.1 2061360 2063099 R identified by match to protein family HMM PF01473; match to protein family HMM PF04650; match to protein family HMM PF05062; match to protein family HMM TIGR01168; SigA binding protein complement(2061360..2063099) Streptococcus pneumoniae P1031 7681157 YP_002739270.1 CDS SPP_2243 NC_012467.1 2063178 2063705 R identified by match to protein family HMM PF04140; hypothetical protein complement(2063178..2063705) Streptococcus pneumoniae P1031 7682410 YP_002739271.1 CDS SPP_2244 NC_012467.1 2063788 2065119 R identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; histidine kinase complement(2063788..2065119) Streptococcus pneumoniae P1031 7680657 YP_002739272.1 CDS SPP_2245 NC_012467.1 2065116 2065769 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator complement(2065116..2065769) Streptococcus pneumoniae P1031 7681358 YP_002739273.1 CDS SPP_2246 NC_012467.1 2065822 2066019 D identified by glimmer; putative; hypothetical protein 2065822..2066019 Streptococcus pneumoniae P1031 7681072 YP_002739274.1 CDS SPP_2247 NC_012467.1 2066209 2066340 D DNA alkylation repair enzyme 2066209..2066340 Streptococcus pneumoniae P1031 7681944 YP_002739275.1 CDS SPP_2248 NC_012467.1 2066411 2068843 R identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; chaperone ClpB 1 complement(2066411..2068843) Streptococcus pneumoniae P1031 7682484 YP_002739276.1 CDS SPP_2249 NC_012467.1 2068845 2069303 R identified by match to protein family HMM PF05848; transcriptional regulator CtsR complement(2068845..2069303) Streptococcus pneumoniae P1031 7681244 YP_002739277.1 CDS SPP_2250 NC_012467.1 2069422 2070150 R identified by match to protein family HMM PF00005; anion ABC transporter ATP-binding protein complement(2069422..2070150) Streptococcus pneumoniae P1031 7682470 YP_002739278.1 CDS SPP_2251 NC_012467.1 2070150 2071157 R identified by match to protein family HMM PF09084; ABC transporter substrate-binding protein complement(2070150..2071157) Streptococcus pneumoniae P1031 7681909 YP_002739279.1 CDS SPP_2252 NC_012467.1 2071195 2071956 R identified by match to protein family HMM PF00528; ABC transporter permease complement(2071195..2071956) Streptococcus pneumoniae P1031 7681218 YP_002739280.1 CDS SPP_2253 NC_012467.1 2071916 2072206 R hypothetical protein complement(2071916..2072206) Streptococcus pneumoniae P1031 7681246 YP_002739281.1 CDS SPP_2254 NC_012467.1 2072462 2073808 R identified by match to protein family HMM PF01473; match to protein family HMM PF05257; match to protein family HMM PF08460; choline binding protein D complement(2072462..2073808) Streptococcus pneumoniae P1031 7682773 YP_002739282.1 CDS SPP_2255 NC_012467.1 2073897 2074163 R identified by match to protein family HMM PF06257; hypothetical protein complement(2073897..2074163) Streptococcus pneumoniae P1031 7681452 YP_002739283.1 CDS dnaB NC_012467.1 2074165 2075517 R unwinds double stranded DNA; replicative DNA helicase complement(2074165..2075517) Streptococcus pneumoniae P1031 7681516 YP_002739284.1 CDS rplI NC_012467.1 2075561 2076013 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(2075561..2076013) Streptococcus pneumoniae P1031 7681200 YP_002739285.1 CDS SPP_2258 NC_012467.1 2076010 2077983 R identified by match to protein family HMM PF01368; match to protein family HMM PF02272; DHH subfamily 1 protein complement(2076010..2077983) Streptococcus pneumoniae P1031 7682041 YP_002739286.1 CDS SPP_2259 NC_012467.1 2078119 2078667 R identified by match to protein family HMM PF02482; match to protein family HMM TIGR00741; ribosome-associated protein Y complement(2078119..2078667) Streptococcus pneumoniae P1031 7682723 YP_002739287.1 CDS SPP_2260 NC_012467.1 2078747 2079409 R putative competence protein ComF complement(2078747..2079409) Streptococcus pneumoniae P1031 7681747 YP_002739288.1 CDS SPP_2261 NC_012467.1 2079406 2080704 R identified by match to protein family HMM PF00271; match to protein family HMM PF04851; superfamily II ATP-dependent DNA/RNA helicase required for DNA uptake complement(2079406..2080704) Streptococcus pneumoniae P1031 7682317 YP_002739289.1 CDS SPP_2262 NC_012467.1 2080760 2081395 D identified by match to protein family HMM PF01205; match to protein family HMM PF09186; match to protein family HMM TIGR00257; hypothetical protein 2080760..2081395 Streptococcus pneumoniae P1031 7681352 YP_002739290.1 CDS cysK NC_012467.1 2081680 2082600 D identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; cysteine synthase A 2081680..2082600 Streptococcus pneumoniae P1031 7682545 YP_002739291.1 CDS SPP_2264 NC_012467.1 2082797 2083066 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(2082797..2083066) Streptococcus pneumoniae P1031 7682264 YP_002739292.1 CDS SPP_2265 NC_012467.1 2083651 2083938 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a premature stop; identified by match to protein family HMM PF05717; transposase complement(2083651..2083938) Streptococcus pneumoniae P1031 7681862 YP_002739293.1 CDS tsf NC_012467.1 2084184 2085224 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(2084184..2085224) Streptococcus pneumoniae P1031 7681507 YP_002739294.1 CDS rpsB NC_012467.1 2085303 2086082 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(2085303..2086082) Streptococcus pneumoniae P1031 7682025 YP_002739295.1 CDS SPP_2268 NC_012467.1 2086306 2087484 R identified by match to protein family HMM PF05257; general stress protein GSP-781 complement(2086306..2087484) Streptococcus pneumoniae P1031 7681898 YP_002739296.1 CDS mreD NC_012467.1 2087578 2088072 R identified by match to protein family HMM PF04093; match to protein family HMM TIGR03426; rod shape-determining protein MreD complement(2087578..2088072) Streptococcus pneumoniae P1031 7681119 YP_002739297.1 CDS mreC NC_012467.1 2088072 2088890 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(2088072..2088890) Streptococcus pneumoniae P1031 7681296 YP_002739298.1 CDS SPP_2271 NC_012467.1 2088949 2089743 R identified by match to protein family HMM PF02361; ABC transporter permease complement(2088949..2089743) Streptococcus pneumoniae P1031 7682857 YP_002739299.1 CDS cbiO NC_012467.1 2089736 2090575 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2089736..2090575) Streptococcus pneumoniae P1031 7680791 YP_002739300.1 CDS cbiO NC_012467.1 2090560 2091387 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2090560..2091387) Streptococcus pneumoniae P1031 7681482 YP_002739301.1 CDS pgsA NC_012467.1 2091384 2091929 R identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase complement(2091384..2091929) Streptococcus pneumoniae P1031 7680794 YP_002739302.1 CDS SPP_2275 NC_012467.1 2091940 2092761 R hypothetical protein complement(2091940..2092761) Streptococcus pneumoniae P1031 7681478 YP_002739303.1 CDS SPP_2276 NC_012467.1 2092803 2094086 R identified by match to protein family HMM PF00675; match to protein family HMM PF05193; peptidase, M16 family complement(2092803..2094086) Streptococcus pneumoniae P1031 7680968 YP_002739304.1 CDS SPP_2277 NC_012467.1 2094083 2095333 R identified by match to protein family HMM PF05193; peptidase, M16 family complement(2094083..2095333) Streptococcus pneumoniae P1031 7682214 YP_002739305.1 CDS SPP_2278 NC_012467.1 2095492 2095860 D identified by match to protein family HMM TIGR02988; S4 domain protein YaaA, putative 2095492..2095860 Streptococcus pneumoniae P1031 7681163 YP_002739306.1 CDS recF NC_012467.1 2095863 2096960 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2095863..2096960 Streptococcus pneumoniae P1031 7682645 YP_002739307.1 CDS guaB NC_012467.1 2097011 2098489 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2097011..2098489) Streptococcus pneumoniae P1031 7681786 YP_002739308.1 CDS trpS NC_012467.1 2098641 2099666 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II complement(2098641..2099666) Streptococcus pneumoniae P1031 7681312 YP_002739309.1 CDS SPP_2282 NC_012467.1 2099872 2101494 D identified by match to protein family HMM PF00005; ATPase component of ABC transporters with duplicated ATPase domains 2099872..2101494 Streptococcus pneumoniae P1031 7681971 YP_002739310.1 CDS SPP_2283 NC_012467.1 2101556 2104108 D ABC transporter permease 2101556..2104108 Streptococcus pneumoniae P1031 7681219 YP_002739311.1 CDS SPP_2285 NC_012467.1 2104551 2104889 R phage infection protein complement(2104551..2104889) Streptococcus pneumoniae P1031 7682202 YP_002739312.1 CDS SPP_2286 NC_012467.1 2104974 2105741 R hypothetical protein complement(2104974..2105741) Streptococcus pneumoniae P1031 7681759 YP_002739313.1 CDS SPP_2287 NC_012467.1 2105920 2106462 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 2105920..2106462 Streptococcus pneumoniae P1031 7682750 YP_002739314.1 CDS SPP_2290 NC_012467.1 2106705 2107457 R identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator complement(2106705..2107457) Streptococcus pneumoniae P1031 7680771 YP_002739315.1 CDS SPP_2291 NC_012467.1 2107454 2108779 R identified by match to protein family HMM PF02518; ComD complement(2107454..2108779) Streptococcus pneumoniae P1031 7681777 YP_002739316.1 CDS SPP_2292 NC_012467.1 2108800 2108925 R identified by match to protein family HMM PF03047; hypothetical protein complement(2108800..2108925) Streptococcus pneumoniae P1031 7682261 YP_002739317.1 CDS SPP_2294 NC_012467.1 2109207 2109686 R SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(2109207..2109686) Streptococcus pneumoniae P1031 7680727 YP_002739318.1 CDS SPP_2295 NC_012467.1 2109869 2111050 D identified by match to protein family HMM PF00089; trypsin domain protein 2109869..2111050 Streptococcus pneumoniae P1031 7681537 YP_002739319.1 CDS SPP_2296 NC_012467.1 2111108 2111866 D identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; stage 0 sporulation protein J 2111108..2111866 Streptococcus pneumoniae P1031 7681384 SPP_0015 tRNA SPP_0015 NC_012467.1 15024 15098 D tRNA-Glu 15024..15098 Streptococcus pneumoniae P1031 7682664 SPP_0017 tRNA SPP_0017 NC_012467.1 16944 17021 D tRNA-Ala 16944..17021 Streptococcus pneumoniae P1031 7680707 SPP_0021 tRNA SPP_0021 NC_012467.1 20241 20317 D tRNA-Asn 20241..20317 Streptococcus pneumoniae P1031 7682155 SPP_0869 tRNA SPP_0869 NC_012467.1 789471 789554 D tRNA-Tyr 789471..789554 Streptococcus pneumoniae P1031 7681561 SPP_0870 tRNA SPP_0870 NC_012467.1 789561 789635 D tRNA-Gln 789561..789635 Streptococcus pneumoniae P1031 7680772 SPP_0882 tRNA SPP_0882 NC_012467.1 802620 802712 R tRNA-Ser complement(802620..802712) Streptococcus pneumoniae P1031 7680773 SPP_1019 tRNA SPP_1019 NC_012467.1 934157 934232 D tRNA-Thr 934157..934232 Streptococcus pneumoniae P1031 7682589 SPP_1286 tRNA SPP_1286 NC_012467.1 1206350 1206426 R tRNA-Arg complement(1206350..1206426) Streptococcus pneumoniae P1031 7681433 SPP_1332 tRNA SPP_1332 NC_012467.1 1249107 1249181 R tRNA-Arg complement(1249107..1249181) Streptococcus pneumoniae P1031 7680923 SPP_1604 tRNA SPP_1604 NC_012467.1 1484621 1484711 R tRNA-Leu complement(1484621..1484711) Streptococcus pneumoniae P1031 7682738 SPP_1792 tRNA SPP_1792 NC_012467.1 1665574 1665651 D tRNA-Lys 1665574..1665651 Streptococcus pneumoniae P1031 7680889 SPP_1907 tRNA SPP_1907 NC_012467.1 1772061 1772153 R tRNA-Ser complement(1772061..1772153) Streptococcus pneumoniae P1031 7682125 SPP_1908 tRNA SPP_1908 NC_012467.1 1772155 1772233 R tRNA-Ile complement(1772155..1772233) Streptococcus pneumoniae P1031 7680755 SPP_1909 tRNA SPP_1909 NC_012467.1 1772265 1772338 R tRNA-Gly complement(1772265..1772338) Streptococcus pneumoniae P1031 7680762 SPP_1910 tRNA SPP_1910 NC_012467.1 1772355 1772430 R tRNA-Phe complement(1772355..1772430) Streptococcus pneumoniae P1031 7680731 SPP_1911 tRNA SPP_1911 NC_012467.1 1772431 1772507 R tRNA-Met complement(1772431..1772507) Streptococcus pneumoniae P1031 7680752 SPP_1912 tRNA SPP_1912 NC_012467.1 1772515 1772607 R tRNA-Ser complement(1772515..1772607) Streptococcus pneumoniae P1031 7680722 SPP_1913 tRNA SPP_1913 NC_012467.1 1772615 1772691 R tRNA-Met complement(1772615..1772691) Streptococcus pneumoniae P1031 7680742 SPP_1914 tRNA SPP_1914 NC_012467.1 1772701 1772779 R tRNA-Met complement(1772701..1772779) Streptococcus pneumoniae P1031 7680753 SPP_1915 tRNA SPP_1915 NC_012467.1 1772780 1772858 R tRNA-Pro complement(1772780..1772858) Streptococcus pneumoniae P1031 7680730 SPP_1916 tRNA SPP_1916 NC_012467.1 1772870 1772946 R tRNA-Arg complement(1772870..1772946) Streptococcus pneumoniae P1031 7680739 SPP_1917 tRNA SPP_1917 NC_012467.1 1772953 1773041 R tRNA-Leu complement(1772953..1773041) Streptococcus pneumoniae P1031 7680719 SPP_1918 tRNA SPP_1918 NC_012467.1 1773046 1773120 R tRNA-Gly complement(1773046..1773120) Streptococcus pneumoniae P1031 7680721 SPP_1919 tRNA SPP_1919 NC_012467.1 1773140 1773215 R tRNA-Thr complement(1773140..1773215) Streptococcus pneumoniae P1031 7680766 SPP_1920 tRNA SPP_1920 NC_012467.1 1773230 1773316 R tRNA-Leu complement(1773230..1773316) Streptococcus pneumoniae P1031 7680751 SPP_1921 tRNA SPP_1921 NC_012467.1 1773318 1773393 R tRNA-Lys complement(1773318..1773393) Streptococcus pneumoniae P1031 7680744 SPP_1922 tRNA SPP_1922 NC_012467.1 1773418 1773490 R tRNA-Asp complement(1773418..1773490) Streptococcus pneumoniae P1031 7680769 SPP_2299 tRNA SPP_2299 NC_012467.1 1773493 1773565 R tRNA-Val complement(1773493..1773565) Streptococcus pneumoniae P1031 7680764 SPP_1926 tRNA SPP_1926 NC_012467.1 1776784 1776861 R tRNA-Ala complement(1776784..1776861) Streptococcus pneumoniae P1031 7682151 SPP_1928 tRNA SPP_1928 NC_012467.1 1778707 1778781 R tRNA-Glu complement(1778707..1778781) Streptococcus pneumoniae P1031 7682148 SPP_1982 tRNA SPP_1982 NC_012467.1 1825108 1825183 D tRNA-Cys 1825108..1825183 Streptococcus pneumoniae P1031 7681532 SPP_2030 tRNA SPP_2030 NC_012467.1 1864760 1864838 R tRNA-Pro complement(1864760..1864838) Streptococcus pneumoniae P1031 7680912 SPP_2031 tRNA SPP_2031 NC_012467.1 1864850 1864926 R tRNA-Arg complement(1864850..1864926) Streptococcus pneumoniae P1031 7680720 SPP_2032 tRNA SPP_2032 NC_012467.1 1864933 1865021 R tRNA-Leu complement(1864933..1865021) Streptococcus pneumoniae P1031 7680716 SPP_2033 tRNA SPP_2033 NC_012467.1 1865026 1865100 R tRNA-Gly complement(1865026..1865100) Streptococcus pneumoniae P1031 7680757 SPP_2034 tRNA SPP_2034 NC_012467.1 1865120 1865195 R tRNA-Thr complement(1865120..1865195) Streptococcus pneumoniae P1031 7680763 SPP_2035 tRNA SPP_2035 NC_012467.1 1865210 1865296 R tRNA-Leu complement(1865210..1865296) Streptococcus pneumoniae P1031 7680738 SPP_2036 tRNA SPP_2036 NC_012467.1 1865298 1865373 R tRNA-Lys complement(1865298..1865373) Streptococcus pneumoniae P1031 7680758 SPP_2037 tRNA SPP_2037 NC_012467.1 1865398 1865470 R tRNA-Asp complement(1865398..1865470) Streptococcus pneumoniae P1031 7680735 SPP_2301 tRNA SPP_2301 NC_012467.1 1865473 1865545 R tRNA-Val complement(1865473..1865545) Streptococcus pneumoniae P1031 7680768 SPP_2041 tRNA SPP_2041 NC_012467.1 1868764 1868841 R tRNA-Ala complement(1868764..1868841) Streptococcus pneumoniae P1031 7682150 SPP_2043 tRNA SPP_2043 NC_012467.1 1870687 1870761 R tRNA-Glu complement(1870687..1870761) Streptococcus pneumoniae P1031 7682153 SPP_2107 tRNA SPP_2107 NC_012467.1 1926642 1926730 R tRNA-Leu complement(1926642..1926730) Streptococcus pneumoniae P1031 7682467 SPP_2108 tRNA SPP_2108 NC_012467.1 1926735 1926811 R tRNA-Gln complement(1926735..1926811) Streptococcus pneumoniae P1031 7680737 SPP_2109 tRNA SPP_2109 NC_012467.1 1926820 1926897 R tRNA-His complement(1926820..1926897) Streptococcus pneumoniae P1031 7680729 SPP_2110 tRNA SPP_2110 NC_012467.1 1926911 1926983 R tRNA-Trp complement(1926911..1926983) Streptococcus pneumoniae P1031 7680761 SPP_2300 tRNA SPP_2300 NC_012467.1 1926986 1927066 R tRNA-Tyr complement(1926986..1927066) Streptococcus pneumoniae P1031 7680765 SPP_2111 tRNA SPP_2111 NC_012467.1 1927076 1927151 R tRNA-Phe complement(1927076..1927151) Streptococcus pneumoniae P1031 7680732 SPP_2112 tRNA SPP_2112 NC_012467.1 1927152 1927228 R tRNA-Met complement(1927152..1927228) Streptococcus pneumoniae P1031 7680724 SPP_2113 tRNA SPP_2113 NC_012467.1 1927239 1927331 R tRNA-Ser complement(1927239..1927331) Streptococcus pneumoniae P1031 7680767 SPP_2114 tRNA SPP_2114 NC_012467.1 1927410 1927488 R tRNA-Ile complement(1927410..1927488) Streptococcus pneumoniae P1031 7680733 SPP_2115 tRNA SPP_2115 NC_012467.1 1927518 1927593 R tRNA-Gly complement(1927518..1927593) Streptococcus pneumoniae P1031 7680728 SPP_2116 tRNA SPP_2116 NC_012467.1 1927595 1927670 R tRNA-Val complement(1927595..1927670) Streptococcus pneumoniae P1031 7680770 SPP_2120 tRNA SPP_2120 NC_012467.1 1930889 1930966 R tRNA-Ala complement(1930889..1930966) Streptococcus pneumoniae P1031 7680708 SPP_2122 tRNA SPP_2122 NC_012467.1 1932812 1932886 R tRNA-Glu complement(1932812..1932886) Streptococcus pneumoniae P1031 7682147 SPP_2288 tRNA SPP_2288 NC_012467.1 2106500 2106576 R tRNA-Asn complement(2106500..2106576) Streptococcus pneumoniae P1031 7680824 SPP_2289 tRNA SPP_2289 NC_012467.1 2106579 2106653 R tRNA-Glu complement(2106579..2106653) Streptococcus pneumoniae P1031 7680726 SPP_2293 tRNA SPP_2293 NC_012467.1 2109087 2109163 R tRNA-Arg complement(2109087..2109163) Streptococcus pneumoniae P1031 7682580 SPP_0016 rRNA rrs1 NC_012467.1 15373 16806 D 16S ribosomal RNA 15373..16806 Streptococcus pneumoniae P1031 7680740 SPP_0019 rRNA rrl1 NC_012467.1 17142 20043 D 23S ribosomal RNA 17142..20043 Streptococcus pneumoniae P1031 7680746 SPP_0020 rRNA rrf1 NC_012467.1 20120 20235 D 5S ribosomal RNA 20120..20235 Streptococcus pneumoniae P1031 7682154 SPP_1923 rRNA rrf2 NC_012467.1 1773570 1773685 R 5S ribosomal RNA complement(1773570..1773685) Streptococcus pneumoniae P1031 7680749 SPP_1924 rRNA rrl2 NC_012467.1 1773762 1776663 R 23S ribosomal RNA complement(1773762..1776663) Streptococcus pneumoniae P1031 7682149 SPP_1927 rRNA rrs2 NC_012467.1 1776999 1778432 R 16S ribosomal RNA complement(1776999..1778432) Streptococcus pneumoniae P1031 7680718 SPP_2038 rRNA rrf3 NC_012467.1 1865550 1865665 R 5S ribosomal RNA complement(1865550..1865665) Streptococcus pneumoniae P1031 7680715 SPP_2039 rRNA rrl3 NC_012467.1 1865742 1868643 R 23S ribosomal RNA complement(1865742..1868643) Streptococcus pneumoniae P1031 7682152 SPP_2042 rRNA rrs3 NC_012467.1 1868979 1870412 R 16S ribosomal RNA complement(1868979..1870412) Streptococcus pneumoniae P1031 7680748 SPP_2117 rRNA rrf4 NC_012467.1 1927675 1927790 R 5S ribosomal RNA complement(1927675..1927790) Streptococcus pneumoniae P1031 7680745 SPP_2118 rRNA rrl4 NC_012467.1 1927867 1930768 R 23S ribosomal RNA complement(1927867..1930768) Streptococcus pneumoniae P1031 7680709 SPP_2121 rRNA rrs4 NC_012467.1 1931104 1932537 R 16S ribosomal RNA complement(1931104..1932537) Streptococcus pneumoniae P1031 7680717