-- dump date   	20140620_084901
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
488223000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
488223000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223000003	Walker A motif; other site
488223000004	ATP binding site [chemical binding]; other site
488223000005	Walker B motif; other site
488223000006	arginine finger; other site
488223000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
488223000008	DnaA box-binding interface [nucleotide binding]; other site
488223000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
488223000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
488223000011	putative DNA binding surface [nucleotide binding]; other site
488223000012	dimer interface [polypeptide binding]; other site
488223000013	beta-clamp/clamp loader binding surface; other site
488223000014	beta-clamp/translesion DNA polymerase binding surface; other site
488223000015	Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864
488223000016	GTP-binding protein YchF; Reviewed; Region: PRK09601
488223000017	YchF GTPase; Region: YchF; cd01900
488223000018	G1 box; other site
488223000019	GTP/Mg2+ binding site [chemical binding]; other site
488223000020	Switch I region; other site
488223000021	G2 box; other site
488223000022	Switch II region; other site
488223000023	G3 box; other site
488223000024	G4 box; other site
488223000025	G5 box; other site
488223000026	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
488223000027	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
488223000028	putative active site [active]
488223000029	catalytic residue [active]
488223000030	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
488223000031	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
488223000032	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488223000033	ATP binding site [chemical binding]; other site
488223000034	putative Mg++ binding site [ion binding]; other site
488223000035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488223000036	nucleotide binding region [chemical binding]; other site
488223000037	ATP-binding site [chemical binding]; other site
488223000038	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
488223000039	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
488223000040	RNA binding surface [nucleotide binding]; other site
488223000041	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
488223000042	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
488223000043	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
488223000044	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
488223000045	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
488223000046	Ligand Binding Site [chemical binding]; other site
488223000047	TilS substrate C-terminal domain; Region: TilS_C; smart00977
488223000048	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488223000049	active site
488223000050	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
488223000051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223000052	Walker A motif; other site
488223000053	ATP binding site [chemical binding]; other site
488223000054	Walker B motif; other site
488223000055	arginine finger; other site
488223000056	Peptidase family M41; Region: Peptidase_M41; pfam01434
488223000057	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
488223000058	Helix-turn-helix domain; Region: HTH_28; pfam13518
488223000059	Winged helix-turn helix; Region: HTH_29; pfam13551
488223000060	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
488223000061	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
488223000062	GDP-binding site [chemical binding]; other site
488223000063	ACT binding site; other site
488223000064	IMP binding site; other site
488223000065	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
488223000066	active site
488223000067	catalytic residues [active]
488223000068	DNA binding site [nucleotide binding]
488223000069	Int/Topo IB signature motif; other site
488223000070	HIRAN domain; Region: HIRAN; pfam08797
488223000071	Domain of unknown function (DUF955); Region: DUF955; cl01076
488223000072	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
488223000073	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488223000074	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223000075	non-specific DNA binding site [nucleotide binding]; other site
488223000076	salt bridge; other site
488223000077	sequence-specific DNA binding site [nucleotide binding]; other site
488223000078	Prophage antirepressor [Transcription]; Region: COG3617
488223000079	BRO family, N-terminal domain; Region: Bro-N; smart01040
488223000080	ORF6C domain; Region: ORF6C; pfam10552
488223000081	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
488223000082	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
488223000083	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223000084	Walker A motif; other site
488223000085	ATP binding site [chemical binding]; other site
488223000086	Walker B motif; other site
488223000087	arginine finger; other site
488223000088	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
488223000089	YopX protein; Region: YopX; cl09859
488223000090	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
488223000091	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
488223000092	Int/Topo IB signature motif; other site
488223000093	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
488223000094	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488223000095	ATP binding site [chemical binding]; other site
488223000096	putative Mg++ binding site [ion binding]; other site
488223000097	Phage-related protein [Function unknown]; Region: COG4695; cl01923
488223000098	phage portal protein, HK97 family; Region: portal_HK97; TIGR01537
488223000099	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
488223000100	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
488223000101	Phage capsid family; Region: Phage_capsid; pfam05065
488223000102	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
488223000103	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
488223000104	Phage-related minor tail protein [Function unknown]; Region: COG5280
488223000105	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
488223000106	membrane protein P6; Region: PHA01399
488223000107	Phage-related minor tail protein [Function unknown]; Region: COG5281
488223000108	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
488223000109	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
488223000110	toxin secretion/phage lysis holin; Region: holin_tox_secr; TIGR01593
488223000111	Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890
488223000112	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
488223000113	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
488223000114	amidase catalytic site [active]
488223000115	Zn binding residues [ion binding]; other site
488223000116	substrate binding site [chemical binding]; other site
488223000117	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
488223000118	nucleoside/Zn binding site; other site
488223000119	dimer interface [polypeptide binding]; other site
488223000120	catalytic motif [active]
488223000121	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
488223000122	trimer interface [polypeptide binding]; other site
488223000123	active site
488223000124	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
488223000125	catalytic core [active]
488223000126	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
488223000127	DNA repair protein RadA; Provisional; Region: PRK11823
488223000128	Walker A motif; other site
488223000129	ATP binding site [chemical binding]; other site
488223000130	Walker B motif; other site
488223000131	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
488223000132	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
488223000133	active site clefts [active]
488223000134	zinc binding site [ion binding]; other site
488223000135	dimer interface [polypeptide binding]; other site
488223000136	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
488223000137	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
488223000138	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
488223000139	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488223000140	active site
488223000141	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
488223000142	DNA polymerase I; Provisional; Region: PRK05755
488223000143	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
488223000144	active site
488223000145	metal binding site 1 [ion binding]; metal-binding site
488223000146	putative 5' ssDNA interaction site; other site
488223000147	metal binding site 3; metal-binding site
488223000148	metal binding site 2 [ion binding]; metal-binding site
488223000149	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
488223000150	putative DNA binding site [nucleotide binding]; other site
488223000151	putative metal binding site [ion binding]; other site
488223000152	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
488223000153	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
488223000154	active site
488223000155	DNA binding site [nucleotide binding]
488223000156	catalytic site [active]
488223000157	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
488223000158	Predicted membrane protein [Function unknown]; Region: COG2855
488223000159	aromatic amino acid aminotransferase; Validated; Region: PRK07309
488223000160	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488223000161	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488223000162	homodimer interface [polypeptide binding]; other site
488223000163	catalytic residue [active]
488223000164	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
488223000165	Recombination protein O N terminal; Region: RecO_N; pfam11967
488223000166	Recombination protein O C terminal; Region: RecO_C; pfam02565
488223000167	putative phosphate acyltransferase; Provisional; Region: PRK05331
488223000168	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
488223000169	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
488223000170	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
488223000171	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
488223000172	putative active site [active]
488223000173	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488223000174	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223000175	Walker A/P-loop; other site
488223000176	ATP binding site [chemical binding]; other site
488223000177	Q-loop/lid; other site
488223000178	ABC transporter signature motif; other site
488223000179	Walker B; other site
488223000180	D-loop; other site
488223000181	H-loop/switch region; other site
488223000182	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
488223000183	HlyD family secretion protein; Region: HlyD_3; pfam13437
488223000184	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
488223000185	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
488223000186	ATP binding site [chemical binding]; other site
488223000187	active site
488223000188	substrate binding site [chemical binding]; other site
488223000189	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
488223000190	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
488223000191	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
488223000192	dimerization interface [polypeptide binding]; other site
488223000193	ATP binding site [chemical binding]; other site
488223000194	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
488223000195	dimerization interface [polypeptide binding]; other site
488223000196	ATP binding site [chemical binding]; other site
488223000197	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
488223000198	putative active site [active]
488223000199	catalytic triad [active]
488223000200	amidophosphoribosyltransferase; Provisional; Region: PRK07272
488223000201	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
488223000202	active site
488223000203	tetramer interface [polypeptide binding]; other site
488223000204	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488223000205	active site
488223000206	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
488223000207	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
488223000208	dimerization interface [polypeptide binding]; other site
488223000209	putative ATP binding site [chemical binding]; other site
488223000210	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
488223000211	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
488223000212	active site
488223000213	substrate binding site [chemical binding]; other site
488223000214	cosubstrate binding site; other site
488223000215	catalytic site [active]
488223000216	VanZ like family; Region: VanZ; pfam04892
488223000217	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
488223000218	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
488223000219	purine monophosphate binding site [chemical binding]; other site
488223000220	dimer interface [polypeptide binding]; other site
488223000221	putative catalytic residues [active]
488223000222	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
488223000223	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
488223000224	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
488223000225	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
488223000226	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
488223000227	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
488223000228	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
488223000229	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
488223000230	ATP-grasp domain; Region: ATP-grasp; pfam02222
488223000231	adenylosuccinate lyase; Provisional; Region: PRK07492
488223000232	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
488223000233	tetramer interface [polypeptide binding]; other site
488223000234	active site
488223000235	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
488223000236	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
488223000237	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
488223000238	active site
488223000239	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
488223000240	active site
488223000241	G5 domain; Region: G5; pfam07501
488223000242	G5 domain; Region: G5; pfam07501
488223000243	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
488223000244	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
488223000245	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
488223000246	DNA-binding site [nucleotide binding]; DNA binding site
488223000247	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
488223000248	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
488223000249	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
488223000250	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
488223000251	active site
488223000252	phosphorylation site [posttranslational modification]
488223000253	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
488223000254	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
488223000255	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
488223000256	active pocket/dimerization site; other site
488223000257	active site
488223000258	phosphorylation site [posttranslational modification]
488223000259	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
488223000260	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
488223000261	dimer interface [polypeptide binding]; other site
488223000262	active site
488223000263	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
488223000264	putative active site [active]
488223000265	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
488223000266	active site
488223000267	catalytic residues [active]
488223000268	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
488223000269	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
488223000270	putative metal binding site [ion binding]; other site
488223000271	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
488223000272	active site
488223000273	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
488223000274	putative homotetramer interface [polypeptide binding]; other site
488223000275	putative homodimer-homodimer interface [polypeptide binding]; other site
488223000276	putative allosteric switch controlling residues; other site
488223000277	putative metal binding site [ion binding]; other site
488223000278	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
488223000279	active site residue [active]
488223000280	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
488223000281	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
488223000282	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
488223000283	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
488223000284	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
488223000285	TrkA-N domain; Region: TrkA_N; pfam02254
488223000286	Fibronectin-binding repeat; Region: SSURE; pfam11966
488223000287	Fibronectin-binding repeat; Region: SSURE; pfam11966
488223000288	Fibronectin-binding repeat; Region: SSURE; pfam11966
488223000289	Fibronectin-binding repeat; Region: SSURE; pfam11966
488223000290	Fibronectin-binding repeat; Region: SSURE; pfam11966
488223000291	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
488223000292	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488223000293	active site
488223000294	phosphorylation site [posttranslational modification]
488223000295	intermolecular recognition site; other site
488223000296	dimerization interface [polypeptide binding]; other site
488223000297	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488223000298	DNA binding site [nucleotide binding]
488223000299	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
488223000300	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
488223000301	dimerization interface [polypeptide binding]; other site
488223000302	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
488223000303	dimer interface [polypeptide binding]; other site
488223000304	phosphorylation site [posttranslational modification]
488223000305	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223000306	ATP binding site [chemical binding]; other site
488223000307	Mg2+ binding site [ion binding]; other site
488223000308	G-X-G motif; other site
488223000309	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
488223000310	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
488223000311	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
488223000312	RNA binding surface [nucleotide binding]; other site
488223000313	Helix-turn-helix domain; Region: HTH_28; pfam13518
488223000314	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
488223000315	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223000316	dimer interface [polypeptide binding]; other site
488223000317	conserved gate region; other site
488223000318	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
488223000319	ABC-ATPase subunit interface; other site
488223000320	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
488223000321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223000322	dimer interface [polypeptide binding]; other site
488223000323	conserved gate region; other site
488223000324	putative PBP binding loops; other site
488223000325	ABC-ATPase subunit interface; other site
488223000326	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
488223000327	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
488223000328	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
488223000329	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
488223000330	active site residue [active]
488223000331	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
488223000332	Domain of unknown function (DUF4299); Region: DUF4299; pfam14132
488223000333	Dentin matrix protein 1 (DMP1); Region: DMP1; pfam07263
488223000334	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
488223000335	Predicted membrane protein [Function unknown]; Region: COG4709
488223000336	Predicted transcriptional regulators [Transcription]; Region: COG1695
488223000337	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
488223000338	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
488223000339	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488223000340	putative substrate translocation pore; other site
488223000341	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
488223000342	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
488223000343	Ligand binding site; other site
488223000344	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
488223000345	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
488223000346	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
488223000347	NAD(P) binding site [chemical binding]; other site
488223000348	homodimer interface [polypeptide binding]; other site
488223000349	substrate binding site [chemical binding]; other site
488223000350	active site
488223000351	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
488223000352	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223000353	active site
488223000354	motif I; other site
488223000355	motif II; other site
488223000356	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
488223000357	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
488223000358	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
488223000359	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
488223000360	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
488223000361	putative L-serine binding site [chemical binding]; other site
488223000362	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
488223000363	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
488223000364	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683
488223000365	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
488223000366	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
488223000367	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
488223000368	Walker A/P-loop; other site
488223000369	ATP binding site [chemical binding]; other site
488223000370	Q-loop/lid; other site
488223000371	ABC transporter signature motif; other site
488223000372	Walker B; other site
488223000373	D-loop; other site
488223000374	H-loop/switch region; other site
488223000375	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488223000376	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
488223000377	substrate binding pocket [chemical binding]; other site
488223000378	membrane-bound complex binding site; other site
488223000379	hinge residues; other site
488223000380	Arginosuccinate synthase; Region: Arginosuc_synth; cl17227
488223000381	Leucine-zipper of ternary complex factor MIP1; Region: Lzipper-MIP1; pfam14389
488223000382	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223000383	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223000384	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223000385	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223000386	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223000387	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223000388	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
488223000389	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223000390	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
488223000391	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
488223000392	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
488223000393	nudix motif; other site
488223000394	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
488223000395	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
488223000396	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
488223000397	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
488223000398	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
488223000399	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
488223000400	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
488223000401	hypothetical protein; Provisional; Region: PRK13667
488223000402	class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949
488223000403	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
488223000404	Glycoprotease family; Region: Peptidase_M22; pfam00814
488223000405	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
488223000406	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488223000407	Coenzyme A binding pocket [chemical binding]; other site
488223000408	UGMP family protein; Validated; Region: PRK09604
488223000409	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
488223000410	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
488223000411	Winged helix-turn helix; Region: HTH_33; pfam13592
488223000412	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488223000413	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
488223000414	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
488223000415	Walker A/P-loop; other site
488223000416	ATP binding site [chemical binding]; other site
488223000417	Q-loop/lid; other site
488223000418	ABC transporter signature motif; other site
488223000419	Walker B; other site
488223000420	D-loop; other site
488223000421	H-loop/switch region; other site
488223000422	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
488223000423	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
488223000424	Ligand Binding Site [chemical binding]; other site
488223000425	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
488223000426	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
488223000427	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
488223000428	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
488223000429	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223000430	non-specific DNA binding site [nucleotide binding]; other site
488223000431	salt bridge; other site
488223000432	sequence-specific DNA binding site [nucleotide binding]; other site
488223000433	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
488223000434	CAAX protease self-immunity; Region: Abi; pfam02517
488223000435	CAAX protease self-immunity; Region: Abi; pfam02517
488223000436	AzlC protein; Region: AzlC; cl00570
488223000437	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
488223000438	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
488223000439	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488223000440	substrate binding pocket [chemical binding]; other site
488223000441	membrane-bound complex binding site; other site
488223000442	hinge residues; other site
488223000443	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
488223000444	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
488223000445	hypothetical protein; Provisional; Region: PRK06446
488223000446	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
488223000447	metal binding site [ion binding]; metal-binding site
488223000448	dimer interface [polypeptide binding]; other site
488223000449	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
488223000450	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
488223000451	Walker A/P-loop; other site
488223000452	ATP binding site [chemical binding]; other site
488223000453	Q-loop/lid; other site
488223000454	ABC transporter signature motif; other site
488223000455	Walker B; other site
488223000456	D-loop; other site
488223000457	H-loop/switch region; other site
488223000458	NIL domain; Region: NIL; pfam09383
488223000459	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
488223000460	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
488223000461	Predicted integral membrane protein [Function unknown]; Region: COG5578
488223000462	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
488223000463	HAMP domain; Region: HAMP; pfam00672
488223000464	Histidine kinase; Region: His_kinase; pfam06580
488223000465	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223000466	ATP binding site [chemical binding]; other site
488223000467	Mg2+ binding site [ion binding]; other site
488223000468	G-X-G motif; other site
488223000469	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
488223000470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488223000471	active site
488223000472	phosphorylation site [posttranslational modification]
488223000473	intermolecular recognition site; other site
488223000474	dimerization interface [polypeptide binding]; other site
488223000475	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
488223000476	flavoprotein NrdI; Provisional; Region: PRK02551
488223000477	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
488223000478	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
488223000479	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
488223000480	LytTr DNA-binding domain; Region: LytTR; smart00850
488223000481	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
488223000482	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223000483	ATP binding site [chemical binding]; other site
488223000484	Mg2+ binding site [ion binding]; other site
488223000485	G-X-G motif; other site
488223000486	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
488223000487	ATP binding site [chemical binding]; other site
488223000488	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
488223000489	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
488223000490	homopentamer interface [polypeptide binding]; other site
488223000491	active site
488223000492	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
488223000493	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
488223000494	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
488223000495	dimerization interface [polypeptide binding]; other site
488223000496	active site
488223000497	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
488223000498	Lumazine binding domain; Region: Lum_binding; pfam00677
488223000499	Lumazine binding domain; Region: Lum_binding; pfam00677
488223000500	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
488223000501	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
488223000502	catalytic motif [active]
488223000503	Zn binding site [ion binding]; other site
488223000504	RibD C-terminal domain; Region: RibD_C; cl17279
488223000505	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
488223000506	RuvA N terminal domain; Region: RuvA_N; pfam01330
488223000507	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
488223000508	CAAX protease self-immunity; Region: Abi; pfam02517
488223000509	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
488223000510	putative dimer interface [polypeptide binding]; other site
488223000511	catalytic triad [active]
488223000512	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
488223000513	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
488223000514	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
488223000515	Cl binding site [ion binding]; other site
488223000516	oligomer interface [polypeptide binding]; other site
488223000517	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
488223000518	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
488223000519	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
488223000520	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
488223000521	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
488223000522	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
488223000523	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
488223000524	active site
488223000525	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
488223000526	ArsC family; Region: ArsC; pfam03960
488223000527	putative catalytic residues [active]
488223000528	thiol/disulfide switch; other site
488223000529	hypothetical protein; Provisional; Region: PRK05473
488223000530	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
488223000531	hypothetical protein; Provisional; Region: PRK13678
488223000532	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
488223000533	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
488223000534	Bacterial lipoprotein; Region: DUF3642; pfam12182
488223000535	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
488223000536	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
488223000537	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
488223000538	putative active site [active]
488223000539	catalytic site [active]
488223000540	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
488223000541	putative active site [active]
488223000542	catalytic site [active]
488223000543	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
488223000544	ATP cone domain; Region: ATP-cone; pfam03477
488223000545	Class III ribonucleotide reductase; Region: RNR_III; cd01675
488223000546	effector binding site; other site
488223000547	active site
488223000548	Zn binding site [ion binding]; other site
488223000549	glycine loop; other site
488223000550	Predicted acetyltransferase [General function prediction only]; Region: COG3981
488223000551	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
488223000552	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
488223000553	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
488223000554	FeS/SAM binding site; other site
488223000555	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
488223000556	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
488223000557	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
488223000558	active site
488223000559	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
488223000560	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
488223000561	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
488223000562	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
488223000563	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
488223000564	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
488223000565	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
488223000566	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
488223000567	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
488223000568	putative translocon binding site; other site
488223000569	protein-rRNA interface [nucleotide binding]; other site
488223000570	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
488223000571	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
488223000572	G-X-X-G motif; other site
488223000573	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
488223000574	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
488223000575	23S rRNA interface [nucleotide binding]; other site
488223000576	5S rRNA interface [nucleotide binding]; other site
488223000577	putative antibiotic binding site [chemical binding]; other site
488223000578	L25 interface [polypeptide binding]; other site
488223000579	L27 interface [polypeptide binding]; other site
488223000580	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
488223000581	23S rRNA interface [nucleotide binding]; other site
488223000582	putative translocon interaction site; other site
488223000583	signal recognition particle (SRP54) interaction site; other site
488223000584	L23 interface [polypeptide binding]; other site
488223000585	trigger factor interaction site; other site
488223000586	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
488223000587	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
488223000588	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
488223000589	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
488223000590	RNA binding site [nucleotide binding]; other site
488223000591	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
488223000592	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
488223000593	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
488223000594	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
488223000595	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
488223000596	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
488223000597	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
488223000598	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
488223000599	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
488223000600	5S rRNA interface [nucleotide binding]; other site
488223000601	L27 interface [polypeptide binding]; other site
488223000602	23S rRNA interface [nucleotide binding]; other site
488223000603	L5 interface [polypeptide binding]; other site
488223000604	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
488223000605	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
488223000606	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
488223000607	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
488223000608	23S rRNA binding site [nucleotide binding]; other site
488223000609	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
488223000610	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
488223000611	SecY translocase; Region: SecY; pfam00344
488223000612	adenylate kinase; Reviewed; Region: adk; PRK00279
488223000613	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
488223000614	AMP-binding site [chemical binding]; other site
488223000615	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
488223000616	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
488223000617	rRNA binding site [nucleotide binding]; other site
488223000618	predicted 30S ribosome binding site; other site
488223000619	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
488223000620	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
488223000621	30S ribosomal protein S13; Region: bact_S13; TIGR03631
488223000622	30S ribosomal protein S11; Validated; Region: PRK05309
488223000623	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
488223000624	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
488223000625	alphaNTD homodimer interface [polypeptide binding]; other site
488223000626	alphaNTD - beta interaction site [polypeptide binding]; other site
488223000627	alphaNTD - beta' interaction site [polypeptide binding]; other site
488223000628	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
488223000629	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
488223000630	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
488223000631	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
488223000632	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
488223000633	catalytic core [active]
488223000634	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
488223000635	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
488223000636	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
488223000637	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
488223000638	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
488223000639	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
488223000640	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
488223000641	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
488223000642	active site
488223000643	methionine cluster; other site
488223000644	phosphorylation site [posttranslational modification]
488223000645	metal binding site [ion binding]; metal-binding site
488223000646	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
488223000647	active site
488223000648	P-loop; other site
488223000649	phosphorylation site [posttranslational modification]
488223000650	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
488223000651	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
488223000652	Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882
488223000653	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
488223000654	dimer interface [polypeptide binding]; other site
488223000655	active site
488223000656	glycine loop; other site
488223000657	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
488223000658	active site
488223000659	intersubunit interactions; other site
488223000660	catalytic residue [active]
488223000661	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
488223000662	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
488223000663	dimer interface [polypeptide binding]; other site
488223000664	active site
488223000665	metal binding site [ion binding]; metal-binding site
488223000666	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
488223000667	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
488223000668	HIGH motif; other site
488223000669	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
488223000670	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
488223000671	active site
488223000672	KMSKS motif; other site
488223000673	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
488223000674	tRNA binding surface [nucleotide binding]; other site
488223000675	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
488223000676	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
488223000677	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
488223000678	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488223000679	Coenzyme A binding pocket [chemical binding]; other site
488223000680	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
488223000681	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223000682	Walker A motif; other site
488223000683	ATP binding site [chemical binding]; other site
488223000684	Walker B motif; other site
488223000685	arginine finger; other site
488223000686	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
488223000687	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575
488223000688	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
488223000689	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
488223000690	catalytic residue [active]
488223000691	putative FPP diphosphate  binding site; other site
488223000692	putative FPP binding hydrophobic cleft; other site
488223000693	dimer interface [polypeptide binding]; other site
488223000694	putative IPP diphosphate binding site; other site
488223000695	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
488223000696	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
488223000697	RIP metalloprotease RseP; Region: TIGR00054
488223000698	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
488223000699	active site
488223000700	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
488223000701	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
488223000702	putative substrate binding region [chemical binding]; other site
488223000703	prolyl-tRNA synthetase; Provisional; Region: PRK09194
488223000704	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
488223000705	dimer interface [polypeptide binding]; other site
488223000706	motif 1; other site
488223000707	active site
488223000708	motif 2; other site
488223000709	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
488223000710	putative deacylase active site [active]
488223000711	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
488223000712	active site
488223000713	motif 3; other site
488223000714	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
488223000715	anticodon binding site; other site
488223000716	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
488223000717	beta-galactosidase; Region: BGL; TIGR03356
488223000718	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
488223000719	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
488223000720	glutaminase active site [active]
488223000721	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
488223000722	dimer interface [polypeptide binding]; other site
488223000723	active site
488223000724	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
488223000725	dimer interface [polypeptide binding]; other site
488223000726	active site
488223000727	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
488223000728	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
488223000729	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
488223000730	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
488223000731	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
488223000732	carbohydrate binding site [chemical binding]; other site
488223000733	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
488223000734	carbohydrate binding site [chemical binding]; other site
488223000735	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
488223000736	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
488223000737	Ca binding site [ion binding]; other site
488223000738	active site
488223000739	catalytic site [active]
488223000740	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
488223000741	S17 interaction site [polypeptide binding]; other site
488223000742	S8 interaction site; other site
488223000743	16S rRNA interaction site [nucleotide binding]; other site
488223000744	streptomycin interaction site [chemical binding]; other site
488223000745	23S rRNA interaction site [nucleotide binding]; other site
488223000746	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
488223000747	30S ribosomal protein S7; Validated; Region: PRK05302
488223000748	elongation factor G; Reviewed; Region: PRK00007
488223000749	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
488223000750	G1 box; other site
488223000751	putative GEF interaction site [polypeptide binding]; other site
488223000752	GTP/Mg2+ binding site [chemical binding]; other site
488223000753	Switch I region; other site
488223000754	G2 box; other site
488223000755	G3 box; other site
488223000756	Switch II region; other site
488223000757	G4 box; other site
488223000758	G5 box; other site
488223000759	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
488223000760	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
488223000761	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
488223000762	DNA polymerase III PolC; Validated; Region: polC; PRK00448
488223000763	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
488223000764	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
488223000765	generic binding surface II; other site
488223000766	generic binding surface I; other site
488223000767	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
488223000768	active site
488223000769	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
488223000770	active site
488223000771	catalytic site [active]
488223000772	substrate binding site [chemical binding]; other site
488223000773	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
488223000774	putative PHP Thumb interface [polypeptide binding]; other site
488223000775	active site
488223000776	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
488223000777	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
488223000778	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
488223000779	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
488223000780	Predicted membrane protein [Function unknown]; Region: COG2261
488223000781	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
488223000782	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
488223000783	RNA binding surface [nucleotide binding]; other site
488223000784	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
488223000785	active site
488223000786	uracil binding [chemical binding]; other site
488223000787	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
488223000788	trimer interface [polypeptide binding]; other site
488223000789	active site
488223000790	G bulge; other site
488223000791	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
488223000792	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
488223000793	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
488223000794	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
488223000795	active pocket/dimerization site; other site
488223000796	active site
488223000797	phosphorylation site [posttranslational modification]
488223000798	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
488223000799	active site
488223000800	phosphorylation site [posttranslational modification]
488223000801	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
488223000802	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
488223000803	NAD binding site [chemical binding]; other site
488223000804	substrate binding site [chemical binding]; other site
488223000805	catalytic Zn binding site [ion binding]; other site
488223000806	tetramer interface [polypeptide binding]; other site
488223000807	structural Zn binding site [ion binding]; other site
488223000808	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
488223000809	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223000810	active site
488223000811	motif I; other site
488223000812	motif II; other site
488223000813	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
488223000814	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
488223000815	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
488223000816	dihydropteroate synthase; Region: DHPS; TIGR01496
488223000817	substrate binding pocket [chemical binding]; other site
488223000818	dimer interface [polypeptide binding]; other site
488223000819	inhibitor binding site; inhibition site
488223000820	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
488223000821	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
488223000822	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
488223000823	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
488223000824	homodecamer interface [polypeptide binding]; other site
488223000825	GTP cyclohydrolase I; Provisional; Region: PLN03044
488223000826	active site
488223000827	putative catalytic site residues [active]
488223000828	zinc binding site [ion binding]; other site
488223000829	GTP-CH-I/GFRP interaction surface; other site
488223000830	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
488223000831	homooctamer interface [polypeptide binding]; other site
488223000832	active site
488223000833	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
488223000834	catalytic center binding site [active]
488223000835	ATP binding site [chemical binding]; other site
488223000836	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
488223000837	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
488223000838	23S rRNA interface [nucleotide binding]; other site
488223000839	L3 interface [polypeptide binding]; other site
488223000840	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
488223000841	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488223000842	DNA binding site [nucleotide binding]
488223000843	active site
488223000844	Int/Topo IB signature motif; other site
488223000845	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
488223000846	This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595
488223000847	putative active site [active]
488223000848	putative catalytic site [active]
488223000849	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
488223000850	catalytic residues [active]
488223000851	dimer interface [polypeptide binding]; other site
488223000852	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
488223000853	substrate binding site [chemical binding]; other site
488223000854	catalytic residues [active]
488223000855	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
488223000856	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
488223000857	active site
488223000858	intersubunit interface [polypeptide binding]; other site
488223000859	catalytic residue [active]
488223000860	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
488223000861	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
488223000862	substrate binding site [chemical binding]; other site
488223000863	ATP binding site [chemical binding]; other site
488223000864	hypothetical protein; Provisional; Region: PRK09273
488223000865	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
488223000866	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
488223000867	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
488223000868	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
488223000869	NADP binding site [chemical binding]; other site
488223000870	homodimer interface [polypeptide binding]; other site
488223000871	active site
488223000872	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
488223000873	active pocket/dimerization site; other site
488223000874	active site
488223000875	phosphorylation site [posttranslational modification]
488223000876	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
488223000877	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
488223000878	active site
488223000879	phosphorylation site [posttranslational modification]
488223000880	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
488223000881	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
488223000882	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
488223000883	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
488223000884	Transcriptional regulators [Transcription]; Region: PurR; COG1609
488223000885	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
488223000886	DNA binding site [nucleotide binding]
488223000887	domain linker motif; other site
488223000888	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
488223000889	putative dimerization interface [polypeptide binding]; other site
488223000890	putative ligand binding site [chemical binding]; other site
488223000891	Protein of unknown function (DUF3278); Region: DUF3278; pfam11683
488223000892	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223000893	non-specific DNA binding site [nucleotide binding]; other site
488223000894	salt bridge; other site
488223000895	sequence-specific DNA binding site [nucleotide binding]; other site
488223000896	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
488223000897	MraW methylase family; Region: Methyltransf_5; pfam01795
488223000898	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
488223000899	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
488223000900	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
488223000901	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
488223000902	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
488223000903	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
488223000904	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
488223000905	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
488223000906	Mg++ binding site [ion binding]; other site
488223000907	putative catalytic motif [active]
488223000908	putative substrate binding site [chemical binding]; other site
488223000909	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223000910	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
488223000911	Walker A motif; other site
488223000912	ATP binding site [chemical binding]; other site
488223000913	Walker B motif; other site
488223000914	arginine finger; other site
488223000915	UvrB/uvrC motif; Region: UVR; pfam02151
488223000916	MoxR-like ATPases [General function prediction only]; Region: COG0714
488223000917	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223000918	Walker A motif; other site
488223000919	ATP binding site [chemical binding]; other site
488223000920	Walker B motif; other site
488223000921	arginine finger; other site
488223000922	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
488223000923	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
488223000924	LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854
488223000925	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
488223000926	hypothetical protein; Provisional; Region: PRK13663
488223000927	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
488223000928	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
488223000929	Ca binding site [ion binding]; other site
488223000930	active site
488223000931	catalytic site [active]
488223000932	Transposase; Region: HTH_Tnp_IS630; pfam01710
488223000933	Helix-turn-helix domain; Region: HTH_28; pfam13518
488223000934	DNA polymerase processivity factor; Region: DNA_PPF; pfam02916
488223000935	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
488223000936	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
488223000937	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
488223000938	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
488223000939	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
488223000940	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
488223000941	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488223000942	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
488223000943	putative ADP-binding pocket [chemical binding]; other site
488223000944	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
488223000945	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
488223000946	trimer interface [polypeptide binding]; other site
488223000947	active site
488223000948	substrate binding site [chemical binding]; other site
488223000949	CoA binding site [chemical binding]; other site
488223000950	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
488223000951	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488223000952	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
488223000953	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
488223000954	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
488223000955	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
488223000956	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488223000957	NAD(P) binding site [chemical binding]; other site
488223000958	active site
488223000959	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
488223000960	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
488223000961	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
488223000962	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
488223000963	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
488223000964	Transposase; Region: DDE_Tnp_ISL3; pfam01610
488223000965	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
488223000966	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
488223000967	substrate binding site; other site
488223000968	tetramer interface; other site
488223000969	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
488223000970	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
488223000971	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
488223000972	NAD binding site [chemical binding]; other site
488223000973	substrate binding site [chemical binding]; other site
488223000974	homodimer interface [polypeptide binding]; other site
488223000975	active site
488223000976	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
488223000977	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
488223000978	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
488223000979	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
488223000980	peptide binding site [polypeptide binding]; other site
488223000981	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
488223000982	Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905
488223000983	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
488223000984	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
488223000985	Transglycosylase; Region: Transgly; pfam00912
488223000986	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
488223000987	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
488223000988	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
488223000989	hypothetical protein; Provisional; Region: PRK13660
488223000990	cell division protein GpsB; Provisional; Region: PRK14127
488223000991	DivIVA domain; Region: DivI1A_domain; TIGR03544
488223000992	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
488223000993	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
488223000994	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
488223000995	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
488223000996	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
488223000997	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
488223000998	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
488223000999	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488223001000	active site
488223001001	phosphorylation site [posttranslational modification]
488223001002	intermolecular recognition site; other site
488223001003	dimerization interface [polypeptide binding]; other site
488223001004	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488223001005	DNA binding site [nucleotide binding]
488223001006	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
488223001007	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
488223001008	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
488223001009	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
488223001010	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
488223001011	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
488223001012	diphosphomevalonate decarboxylase; Region: PLN02407
488223001013	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
488223001014	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
488223001015	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
488223001016	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
488223001017	homotetramer interface [polypeptide binding]; other site
488223001018	FMN binding site [chemical binding]; other site
488223001019	homodimer contacts [polypeptide binding]; other site
488223001020	putative active site [active]
488223001021	putative substrate binding site [chemical binding]; other site
488223001022	Predicted membrane protein [Function unknown]; Region: COG4758
488223001023	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
488223001024	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
488223001025	Histidine kinase; Region: HisKA_3; pfam07730
488223001026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223001027	ATP binding site [chemical binding]; other site
488223001028	Mg2+ binding site [ion binding]; other site
488223001029	G-X-G motif; other site
488223001030	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
488223001031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488223001032	active site
488223001033	phosphorylation site [posttranslational modification]
488223001034	intermolecular recognition site; other site
488223001035	dimerization interface [polypeptide binding]; other site
488223001036	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
488223001037	DNA binding residues [nucleotide binding]
488223001038	dimerization interface [polypeptide binding]; other site
488223001039	A new structural DNA glycosylase; Region: AlkD_like; cl11434
488223001040	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
488223001041	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488223001042	DNA binding site [nucleotide binding]
488223001043	Int/Topo IB signature motif; other site
488223001044	active site
488223001045	trigger factor; Provisional; Region: tig; PRK01490
488223001046	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
488223001047	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
488223001048	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
488223001049	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
488223001050	DNA binding site [nucleotide binding]
488223001051	AAA domain; Region: AAA_30; pfam13604
488223001052	Family description; Region: UvrD_C_2; pfam13538
488223001053	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
488223001054	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
488223001055	Catalytic site [active]
488223001056	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
488223001057	ribonuclease HIII; Provisional; Region: PRK00996
488223001058	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
488223001059	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
488223001060	RNA/DNA hybrid binding site [nucleotide binding]; other site
488223001061	active site
488223001062	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
488223001063	Colicin V production protein; Region: Colicin_V; pfam02674
488223001064	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193
488223001065	MutS domain III; Region: MutS_III; pfam05192
488223001066	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
488223001067	Walker A/P-loop; other site
488223001068	ATP binding site [chemical binding]; other site
488223001069	Q-loop/lid; other site
488223001070	ABC transporter signature motif; other site
488223001071	Walker B; other site
488223001072	D-loop; other site
488223001073	H-loop/switch region; other site
488223001074	Smr domain; Region: Smr; pfam01713
488223001075	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
488223001076	amino acid carrier protein; Region: agcS; TIGR00835
488223001077	Uncharacterized conserved protein [Function unknown]; Region: COG2128
488223001078	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
488223001079	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
488223001080	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
488223001081	gating phenylalanine in ion channel; other site
488223001082	seryl-tRNA synthetase; Provisional; Region: PRK05431
488223001083	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
488223001084	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
488223001085	dimer interface [polypeptide binding]; other site
488223001086	active site
488223001087	motif 1; other site
488223001088	motif 2; other site
488223001089	motif 3; other site
488223001090	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687
488223001091	aspartate kinase; Reviewed; Region: PRK09034
488223001092	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
488223001093	putative catalytic residues [active]
488223001094	putative nucleotide binding site [chemical binding]; other site
488223001095	putative aspartate binding site [chemical binding]; other site
488223001096	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
488223001097	allosteric regulatory residue; other site
488223001098	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
488223001099	enoyl-CoA hydratase; Provisional; Region: PRK07260
488223001100	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
488223001101	substrate binding site [chemical binding]; other site
488223001102	oxyanion hole (OAH) forming residues; other site
488223001103	trimer interface [polypeptide binding]; other site
488223001104	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
488223001105	MarR family; Region: MarR_2; pfam12802
488223001106	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
488223001107	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
488223001108	dimer interface [polypeptide binding]; other site
488223001109	active site
488223001110	CoA binding pocket [chemical binding]; other site
488223001111	acyl carrier protein; Provisional; Region: acpP; PRK00982
488223001112	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
488223001113	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
488223001114	FMN binding site [chemical binding]; other site
488223001115	substrate binding site [chemical binding]; other site
488223001116	putative catalytic residue [active]
488223001117	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
488223001118	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
488223001119	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
488223001120	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
488223001121	NAD(P) binding site [chemical binding]; other site
488223001122	homotetramer interface [polypeptide binding]; other site
488223001123	homodimer interface [polypeptide binding]; other site
488223001124	active site
488223001125	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
488223001126	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
488223001127	dimer interface [polypeptide binding]; other site
488223001128	active site
488223001129	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
488223001130	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
488223001131	carboxyltransferase (CT) interaction site; other site
488223001132	biotinylation site [posttranslational modification]; other site
488223001133	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
488223001134	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
488223001135	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
488223001136	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
488223001137	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
488223001138	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
488223001139	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
488223001140	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
488223001141	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
488223001142	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
488223001143	putative RNA binding site [nucleotide binding]; other site
488223001144	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
488223001145	elongation factor P; Validated; Region: PRK00529
488223001146	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
488223001147	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
488223001148	RNA binding site [nucleotide binding]; other site
488223001149	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
488223001150	RNA binding site [nucleotide binding]; other site
488223001151	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
488223001152	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
488223001153	putative NAD(P) binding site [chemical binding]; other site
488223001154	catalytic Zn binding site [ion binding]; other site
488223001155	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
488223001156	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
488223001157	GatB domain; Region: GatB_Yqey; pfam02637
488223001158	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
488223001159	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
488223001160	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
488223001161	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
488223001162	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
488223001163	G1 box; other site
488223001164	putative GEF interaction site [polypeptide binding]; other site
488223001165	GTP/Mg2+ binding site [chemical binding]; other site
488223001166	Switch I region; other site
488223001167	G2 box; other site
488223001168	G3 box; other site
488223001169	Switch II region; other site
488223001170	G4 box; other site
488223001171	G5 box; other site
488223001172	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
488223001173	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
488223001174	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
488223001175	Ligand binding site; other site
488223001176	metal-binding site
488223001177	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
488223001178	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
488223001179	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
488223001180	DAK2 domain; Region: Dak2; pfam02734
488223001181	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282
488223001182	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
488223001183	PYR/PP interface [polypeptide binding]; other site
488223001184	dimer interface [polypeptide binding]; other site
488223001185	TPP binding site [chemical binding]; other site
488223001186	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
488223001187	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
488223001188	TPP-binding site [chemical binding]; other site
488223001189	dimer interface [polypeptide binding]; other site
488223001190	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
488223001191	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
488223001192	putative valine binding site [chemical binding]; other site
488223001193	dimer interface [polypeptide binding]; other site
488223001194	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
488223001195	ketol-acid reductoisomerase; Provisional; Region: PRK05479
488223001196	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
488223001197	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
488223001198	threonine dehydratase; Validated; Region: PRK08639
488223001199	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
488223001200	tetramer interface [polypeptide binding]; other site
488223001201	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488223001202	catalytic residue [active]
488223001203	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
488223001204	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
488223001205	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223001206	Walker A/P-loop; other site
488223001207	ATP binding site [chemical binding]; other site
488223001208	Q-loop/lid; other site
488223001209	ABC transporter signature motif; other site
488223001210	Walker B; other site
488223001211	D-loop; other site
488223001212	H-loop/switch region; other site
488223001213	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488223001214	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
488223001215	substrate binding pocket [chemical binding]; other site
488223001216	membrane-bound complex binding site; other site
488223001217	hinge residues; other site
488223001218	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223001219	dimer interface [polypeptide binding]; other site
488223001220	conserved gate region; other site
488223001221	putative PBP binding loops; other site
488223001222	ABC-ATPase subunit interface; other site
488223001223	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
488223001224	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
488223001225	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
488223001226	Transposase; Region: DEDD_Tnp_IS110; pfam01548
488223001227	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
488223001228	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
488223001229	active site
488223001230	DNA polymerase IV; Validated; Region: PRK02406
488223001231	DNA binding site [nucleotide binding]
488223001232	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
488223001233	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
488223001234	Transcriptional regulators [Transcription]; Region: MarR; COG1846
488223001235	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
488223001236	non-specific DNA interactions [nucleotide binding]; other site
488223001237	DNA binding site [nucleotide binding]
488223001238	sequence specific DNA binding site [nucleotide binding]; other site
488223001239	putative cAMP binding site [chemical binding]; other site
488223001240	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
488223001241	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
488223001242	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
488223001243	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
488223001244	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
488223001245	methionine cluster; other site
488223001246	active site
488223001247	phosphorylation site [posttranslational modification]
488223001248	metal binding site [ion binding]; metal-binding site
488223001249	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
488223001250	beta-galactosidase; Region: BGL; TIGR03356
488223001251	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
488223001252	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
488223001253	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
488223001254	active site
488223001255	P-loop; other site
488223001256	phosphorylation site [posttranslational modification]
488223001257	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
488223001258	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
488223001259	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
488223001260	TrkA-N domain; Region: TrkA_N; pfam02254
488223001261	TrkA-C domain; Region: TrkA_C; pfam02080
488223001262	TrkA-N domain; Region: TrkA_N; pfam02254
488223001263	TrkA-C domain; Region: TrkA_C; pfam02080
488223001264	Uncharacterized conserved protein [Function unknown]; Region: COG1912
488223001265	hypothetical protein; Provisional; Region: PRK13661
488223001266	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
488223001267	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
488223001268	Walker A/P-loop; other site
488223001269	ATP binding site [chemical binding]; other site
488223001270	Q-loop/lid; other site
488223001271	ABC transporter signature motif; other site
488223001272	Walker B; other site
488223001273	D-loop; other site
488223001274	H-loop/switch region; other site
488223001275	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
488223001276	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
488223001277	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
488223001278	Walker A/P-loop; other site
488223001279	ATP binding site [chemical binding]; other site
488223001280	Q-loop/lid; other site
488223001281	ABC transporter signature motif; other site
488223001282	Walker B; other site
488223001283	D-loop; other site
488223001284	H-loop/switch region; other site
488223001285	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
488223001286	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
488223001287	Predicted membrane protein [Function unknown]; Region: COG3601
488223001288	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
488223001289	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
488223001290	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
488223001291	active site
488223001292	ParB-like nuclease domain; Region: ParBc; cl02129
488223001293	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
488223001294	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
488223001295	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
488223001296	CTP synthetase; Validated; Region: pyrG; PRK05380
488223001297	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
488223001298	Catalytic site [active]
488223001299	active site
488223001300	UTP binding site [chemical binding]; other site
488223001301	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
488223001302	active site
488223001303	putative oxyanion hole; other site
488223001304	catalytic triad [active]
488223001305	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
488223001306	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
488223001307	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
488223001308	PhoU domain; Region: PhoU; pfam01895
488223001309	PhoU domain; Region: PhoU; pfam01895
488223001310	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
488223001311	Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins.  The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547
488223001312	putative active site [active]
488223001313	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
488223001314	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
488223001315	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
488223001316	G5 domain; Region: G5; pfam07501
488223001317	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
488223001318	Phosphoglycerate kinase; Region: PGK; pfam00162
488223001319	substrate binding site [chemical binding]; other site
488223001320	hinge regions; other site
488223001321	ADP binding site [chemical binding]; other site
488223001322	catalytic site [active]
488223001323	Predicted membrane protein [Function unknown]; Region: COG4129
488223001324	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
488223001325	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
488223001326	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
488223001327	DNA binding residues [nucleotide binding]
488223001328	putative dimer interface [polypeptide binding]; other site
488223001329	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
488223001330	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
488223001331	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
488223001332	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
488223001333	unresolved collapsed repeat
488223001334	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
488223001335	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
488223001336	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
488223001337	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
488223001338	VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196
488223001339	Int/Topo IB signature motif; other site
488223001340	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
488223001341	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
488223001342	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
488223001343	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
488223001344	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
488223001345	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
488223001346	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
488223001347	HsdM N-terminal domain; Region: HsdM_N; pfam12161
488223001348	Methyltransferase domain; Region: Methyltransf_26; pfam13659
488223001349	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
488223001350	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
488223001351	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
488223001352	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
488223001353	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
488223001354	dimer interface [polypeptide binding]; other site
488223001355	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
488223001356	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
488223001357	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
488223001358	nucleotide binding site [chemical binding]; other site
488223001359	NEF interaction site [polypeptide binding]; other site
488223001360	SBD interface [polypeptide binding]; other site
488223001361	chaperone protein DnaJ; Provisional; Region: PRK14276
488223001362	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
488223001363	HSP70 interaction site [polypeptide binding]; other site
488223001364	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
488223001365	substrate binding site [polypeptide binding]; other site
488223001366	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
488223001367	Zn binding sites [ion binding]; other site
488223001368	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
488223001369	substrate binding site [polypeptide binding]; other site
488223001370	dimer interface [polypeptide binding]; other site
488223001371	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
488223001372	HIT family signature motif; other site
488223001373	catalytic residue [active]
488223001374	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
488223001375	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
488223001376	Walker A/P-loop; other site
488223001377	ATP binding site [chemical binding]; other site
488223001378	Q-loop/lid; other site
488223001379	ABC transporter signature motif; other site
488223001380	Walker B; other site
488223001381	D-loop; other site
488223001382	H-loop/switch region; other site
488223001383	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
488223001384	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
488223001385	LytTr DNA-binding domain; Region: LytTR; pfam04397
488223001386	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
488223001387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488223001388	active site
488223001389	phosphorylation site [posttranslational modification]
488223001390	intermolecular recognition site; other site
488223001391	dimerization interface [polypeptide binding]; other site
488223001392	LytTr DNA-binding domain; Region: LytTR; pfam04397
488223001393	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
488223001394	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223001395	ATP binding site [chemical binding]; other site
488223001396	Mg2+ binding site [ion binding]; other site
488223001397	G-X-G motif; other site
488223001398	COMC family; Region: ComC; pfam03047
488223001399	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
488223001400	HlyD family secretion protein; Region: HlyD_3; pfam13437
488223001401	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
488223001402	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
488223001403	putative active site [active]
488223001404	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488223001405	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223001406	Walker A/P-loop; other site
488223001407	ATP binding site [chemical binding]; other site
488223001408	Q-loop/lid; other site
488223001409	ABC transporter signature motif; other site
488223001410	Walker B; other site
488223001411	D-loop; other site
488223001412	H-loop/switch region; other site
488223001413	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
488223001414	CAAX protease self-immunity; Region: Abi; pfam02517
488223001415	CAAX protease self-immunity; Region: Abi; pfam02517
488223001416	Phosphotransferase enzyme family; Region: APH; pfam01636
488223001417	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
488223001418	substrate binding site [chemical binding]; other site
488223001419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223001420	S-adenosylmethionine binding site [chemical binding]; other site
488223001421	ribosome maturation protein RimP; Reviewed; Region: PRK00092
488223001422	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
488223001423	putative oligomer interface [polypeptide binding]; other site
488223001424	putative RNA binding site [nucleotide binding]; other site
488223001425	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
488223001426	NusA N-terminal domain; Region: NusA_N; pfam08529
488223001427	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
488223001428	RNA binding site [nucleotide binding]; other site
488223001429	homodimer interface [polypeptide binding]; other site
488223001430	NusA-like KH domain; Region: KH_5; pfam13184
488223001431	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
488223001432	G-X-X-G motif; other site
488223001433	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
488223001434	putative RNA binding cleft [nucleotide binding]; other site
488223001435	hypothetical protein; Provisional; Region: PRK07283
488223001436	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
488223001437	translation initiation factor IF-2; Region: IF-2; TIGR00487
488223001438	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
488223001439	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
488223001440	G1 box; other site
488223001441	putative GEF interaction site [polypeptide binding]; other site
488223001442	GTP/Mg2+ binding site [chemical binding]; other site
488223001443	Switch I region; other site
488223001444	G2 box; other site
488223001445	G3 box; other site
488223001446	Switch II region; other site
488223001447	G4 box; other site
488223001448	G5 box; other site
488223001449	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
488223001450	Translation-initiation factor 2; Region: IF-2; pfam11987
488223001451	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
488223001452	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
488223001453	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
488223001454	Uncharacterized conserved protein [Function unknown]; Region: COG2461
488223001455	Family of unknown function (DUF438); Region: DUF438; pfam04282
488223001456	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
488223001457	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
488223001458	putative active site [active]
488223001459	heme pocket [chemical binding]; other site
488223001460	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
488223001461	hypothetical protein; Provisional; Region: PRK07758
488223001462	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
488223001463	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
488223001464	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
488223001465	AAA domain; Region: AAA_18; pfam13238
488223001466	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
488223001467	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
488223001468	active site
488223001469	HIGH motif; other site
488223001470	nucleotide binding site [chemical binding]; other site
488223001471	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
488223001472	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
488223001473	active site
488223001474	KMSKS motif; other site
488223001475	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
488223001476	tRNA binding surface [nucleotide binding]; other site
488223001477	anticodon binding site; other site
488223001478	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
488223001479	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
488223001480	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
488223001481	Fic/DOC family; Region: Fic; pfam02661
488223001482	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
488223001483	Helix-turn-helix domain; Region: HTH_28; pfam13518
488223001484	Transposase; Region: HTH_Tnp_1; cl17663
488223001485	HTH-like domain; Region: HTH_21; pfam13276
488223001486	transcriptional antiterminator BglG; Provisional; Region: PRK09772
488223001487	CAT RNA binding domain; Region: CAT_RBD; smart01061
488223001488	PRD domain; Region: PRD; pfam00874
488223001489	PRD domain; Region: PRD; pfam00874
488223001490	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
488223001491	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
488223001492	active site turn [active]
488223001493	phosphorylation site [posttranslational modification]
488223001494	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
488223001495	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
488223001496	HPr interaction site; other site
488223001497	glycerol kinase (GK) interaction site [polypeptide binding]; other site
488223001498	active site
488223001499	phosphorylation site [posttranslational modification]
488223001500	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
488223001501	beta-galactosidase; Region: BGL; TIGR03356
488223001502	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
488223001503	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
488223001504	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
488223001505	dimer interface [polypeptide binding]; other site
488223001506	motif 1; other site
488223001507	active site
488223001508	motif 2; other site
488223001509	motif 3; other site
488223001510	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
488223001511	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488223001512	Coenzyme A binding pocket [chemical binding]; other site
488223001513	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
488223001514	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
488223001515	putative tRNA-binding site [nucleotide binding]; other site
488223001516	B3/4 domain; Region: B3_4; pfam03483
488223001517	tRNA synthetase B5 domain; Region: B5; smart00874
488223001518	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
488223001519	dimer interface [polypeptide binding]; other site
488223001520	motif 1; other site
488223001521	motif 3; other site
488223001522	motif 2; other site
488223001523	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
488223001524	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
488223001525	putative catalytic site [active]
488223001526	putative metal binding site [ion binding]; other site
488223001527	putative phosphate binding site [ion binding]; other site
488223001528	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223001529	non-specific DNA binding site [nucleotide binding]; other site
488223001530	salt bridge; other site
488223001531	sequence-specific DNA binding site [nucleotide binding]; other site
488223001532	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
488223001533	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
488223001534	THF binding site; other site
488223001535	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
488223001536	substrate binding site [chemical binding]; other site
488223001537	THF binding site; other site
488223001538	zinc-binding site [ion binding]; other site
488223001539	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
488223001540	FAD binding site [chemical binding]; other site
488223001541	serine O-acetyltransferase; Region: cysE; TIGR01172
488223001542	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
488223001543	trimer interface [polypeptide binding]; other site
488223001544	active site
488223001545	substrate binding site [chemical binding]; other site
488223001546	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488223001547	Coenzyme A binding pocket [chemical binding]; other site
488223001548	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
488223001549	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488223001550	Coenzyme A binding pocket [chemical binding]; other site
488223001551	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
488223001552	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
488223001553	active site
488223001554	HIGH motif; other site
488223001555	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
488223001556	KMSKS motif; other site
488223001557	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
488223001558	tRNA binding surface [nucleotide binding]; other site
488223001559	anticodon binding site; other site
488223001560	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
488223001561	active site
488223001562	metal binding site [ion binding]; metal-binding site
488223001563	dimerization interface [polypeptide binding]; other site
488223001564	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
488223001565	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
488223001566	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
488223001567	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
488223001568	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
488223001569	FtsX-like permease family; Region: FtsX; pfam02687
488223001570	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
488223001571	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
488223001572	Walker A/P-loop; other site
488223001573	ATP binding site [chemical binding]; other site
488223001574	Q-loop/lid; other site
488223001575	ABC transporter signature motif; other site
488223001576	Walker B; other site
488223001577	D-loop; other site
488223001578	H-loop/switch region; other site
488223001579	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
488223001580	FtsX-like permease family; Region: FtsX; pfam02687
488223001581	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
488223001582	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488223001583	active site
488223001584	phosphorylation site [posttranslational modification]
488223001585	intermolecular recognition site; other site
488223001586	dimerization interface [polypeptide binding]; other site
488223001587	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488223001588	DNA binding site [nucleotide binding]
488223001589	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
488223001590	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
488223001591	dimerization interface [polypeptide binding]; other site
488223001592	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
488223001593	dimer interface [polypeptide binding]; other site
488223001594	phosphorylation site [posttranslational modification]
488223001595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223001596	ATP binding site [chemical binding]; other site
488223001597	Mg2+ binding site [ion binding]; other site
488223001598	G-X-G motif; other site
488223001599	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
488223001600	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
488223001601	intersubunit interface [polypeptide binding]; other site
488223001602	active site
488223001603	zinc binding site [ion binding]; other site
488223001604	Na+ binding site [ion binding]; other site
488223001605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223001606	dimer interface [polypeptide binding]; other site
488223001607	conserved gate region; other site
488223001608	putative PBP binding loops; other site
488223001609	ABC-ATPase subunit interface; other site
488223001610	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223001611	dimer interface [polypeptide binding]; other site
488223001612	conserved gate region; other site
488223001613	putative PBP binding loops; other site
488223001614	ABC-ATPase subunit interface; other site
488223001615	bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917
488223001616	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488223001617	substrate binding pocket [chemical binding]; other site
488223001618	membrane-bound complex binding site; other site
488223001619	hinge residues; other site
488223001620	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
488223001621	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
488223001622	Walker A/P-loop; other site
488223001623	ATP binding site [chemical binding]; other site
488223001624	Q-loop/lid; other site
488223001625	ABC transporter signature motif; other site
488223001626	Walker B; other site
488223001627	D-loop; other site
488223001628	H-loop/switch region; other site
488223001629	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
488223001630	DHH family; Region: DHH; pfam01368
488223001631	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
488223001632	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
488223001633	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
488223001634	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
488223001635	Predicted esterase [General function prediction only]; Region: COG0627
488223001636	S-formylglutathione hydrolase; Region: PLN02442
488223001637	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
488223001638	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
488223001639	FemAB family; Region: FemAB; pfam02388
488223001640	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
488223001641	active site
488223001642	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
488223001643	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
488223001644	GIY-YIG motif/motif A; other site
488223001645	active site
488223001646	catalytic site [active]
488223001647	putative DNA binding site [nucleotide binding]; other site
488223001648	metal binding site [ion binding]; metal-binding site
488223001649	UvrB/uvrC motif; Region: UVR; pfam02151
488223001650	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
488223001651	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
488223001652	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
488223001653	active site
488223001654	metal binding site [ion binding]; metal-binding site
488223001655	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
488223001656	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488223001657	substrate binding pocket [chemical binding]; other site
488223001658	membrane-bound complex binding site; other site
488223001659	hinge residues; other site
488223001660	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
488223001661	dimer interface [polypeptide binding]; other site
488223001662	FMN binding site [chemical binding]; other site
488223001663	dipeptidase PepV; Reviewed; Region: PRK07318
488223001664	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
488223001665	active site
488223001666	metal binding site [ion binding]; metal-binding site
488223001667	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
488223001668	putative uracil binding site [chemical binding]; other site
488223001669	putative active site [active]
488223001670	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
488223001671	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
488223001672	active site residue [active]
488223001673	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
488223001674	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
488223001675	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
488223001676	putative oligomer interface [polypeptide binding]; other site
488223001677	putative active site [active]
488223001678	metal binding site [ion binding]; metal-binding site
488223001679	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
488223001680	nucleotide binding site/active site [active]
488223001681	HIT family signature motif; other site
488223001682	catalytic residue [active]
488223001683	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
488223001684	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
488223001685	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
488223001686	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
488223001687	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
488223001688	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
488223001689	23S rRNA interface [nucleotide binding]; other site
488223001690	L7/L12 interface [polypeptide binding]; other site
488223001691	putative thiostrepton binding site; other site
488223001692	L25 interface [polypeptide binding]; other site
488223001693	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
488223001694	mRNA/rRNA interface [nucleotide binding]; other site
488223001695	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
488223001696	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223001697	Walker A/P-loop; other site
488223001698	ATP binding site [chemical binding]; other site
488223001699	Q-loop/lid; other site
488223001700	ABC transporter signature motif; other site
488223001701	Walker B; other site
488223001702	D-loop; other site
488223001703	H-loop/switch region; other site
488223001704	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
488223001705	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
488223001706	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
488223001707	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
488223001708	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
488223001709	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
488223001710	putative active site [active]
488223001711	catalytic triad [active]
488223001712	PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819
488223001713	PA/protease or protease-like domain interface [polypeptide binding]; other site
488223001714	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
488223001715	catalytic residues [active]
488223001716	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
488223001717	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
488223001718	active site
488223001719	phosphorylation site [posttranslational modification]
488223001720	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
488223001721	active site
488223001722	P-loop; other site
488223001723	phosphorylation site [posttranslational modification]
488223001724	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
488223001725	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
488223001726	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
488223001727	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
488223001728	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
488223001729	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
488223001730	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
488223001731	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
488223001732	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
488223001733	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
488223001734	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
488223001735	G5 domain; Region: G5; pfam07501
488223001736	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
488223001737	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
488223001738	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
488223001739	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
488223001740	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
488223001741	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
488223001742	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
488223001743	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
488223001744	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
488223001745	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
488223001746	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
488223001747	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
488223001748	catalytic residues [active]
488223001749	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
488223001750	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
488223001751	SelR domain; Region: SelR; pfam01641
488223001752	Response regulator receiver domain; Region: Response_reg; pfam00072
488223001753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488223001754	active site
488223001755	phosphorylation site [posttranslational modification]
488223001756	intermolecular recognition site; other site
488223001757	dimerization interface [polypeptide binding]; other site
488223001758	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
488223001759	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
488223001760	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
488223001761	Cache domain; Region: Cache_1; pfam02743
488223001762	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
488223001763	dimerization interface [polypeptide binding]; other site
488223001764	Histidine kinase; Region: His_kinase; pfam06580
488223001765	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223001766	ATP binding site [chemical binding]; other site
488223001767	Mg2+ binding site [ion binding]; other site
488223001768	G-X-G motif; other site
488223001769	hypothetical protein; Provisional; Region: PRK13690
488223001770	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
488223001771	G5 domain; Region: G5; pfam07501
488223001772	G5 domain; Region: G5; pfam07501
488223001773	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
488223001774	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
488223001775	aminodeoxychorismate synthase; Provisional; Region: PRK07508
488223001776	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
488223001777	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
488223001778	substrate-cofactor binding pocket; other site
488223001779	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
488223001780	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488223001781	catalytic residue [active]
488223001782	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
488223001783	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
488223001784	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
488223001785	nucleotide binding site [chemical binding]; other site
488223001786	thymidylate synthase; Reviewed; Region: thyA; PRK01827
488223001787	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
488223001788	dimerization interface [polypeptide binding]; other site
488223001789	active site
488223001790	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
488223001791	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
488223001792	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
488223001793	GTPases [General function prediction only]; Region: HflX; COG2262
488223001794	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
488223001795	HflX GTPase family; Region: HflX; cd01878
488223001796	G1 box; other site
488223001797	GTP/Mg2+ binding site [chemical binding]; other site
488223001798	Switch I region; other site
488223001799	G2 box; other site
488223001800	G3 box; other site
488223001801	Switch II region; other site
488223001802	G4 box; other site
488223001803	G5 box; other site
488223001804	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
488223001805	ribonuclease Z; Region: RNase_Z; TIGR02651
488223001806	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
488223001807	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
488223001808	NAD(P) binding site [chemical binding]; other site
488223001809	active site
488223001810	Transcriptional regulator [Transcription]; Region: LysR; COG0583
488223001811	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
488223001812	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
488223001813	dimerization interface [polypeptide binding]; other site
488223001814	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
488223001815	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
488223001816	active site residue [active]
488223001817	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
488223001818	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
488223001819	RNA binding surface [nucleotide binding]; other site
488223001820	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
488223001821	active site
488223001822	uracil binding [chemical binding]; other site
488223001823	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
488223001824	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
488223001825	G1 box; other site
488223001826	putative GEF interaction site [polypeptide binding]; other site
488223001827	GTP/Mg2+ binding site [chemical binding]; other site
488223001828	Switch I region; other site
488223001829	G2 box; other site
488223001830	G3 box; other site
488223001831	Switch II region; other site
488223001832	G4 box; other site
488223001833	G5 box; other site
488223001834	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
488223001835	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
488223001836	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
488223001837	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683
488223001838	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
488223001839	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
488223001840	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223001841	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
488223001842	Walker A/P-loop; other site
488223001843	ATP binding site [chemical binding]; other site
488223001844	Q-loop/lid; other site
488223001845	ABC transporter signature motif; other site
488223001846	Walker B; other site
488223001847	D-loop; other site
488223001848	H-loop/switch region; other site
488223001849	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
488223001850	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
488223001851	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
488223001852	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
488223001853	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
488223001854	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
488223001855	homodimer interface [polypeptide binding]; other site
488223001856	active site
488223001857	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
488223001858	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
488223001859	Cell division protein FtsQ; Region: FtsQ; pfam03799
488223001860	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
488223001861	active site
488223001862	dimer interface [polypeptide binding]; other site
488223001863	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488223001864	active site
488223001865	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
488223001866	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223001867	Walker A/P-loop; other site
488223001868	ATP binding site [chemical binding]; other site
488223001869	Q-loop/lid; other site
488223001870	ABC transporter signature motif; other site
488223001871	Walker B; other site
488223001872	D-loop; other site
488223001873	H-loop/switch region; other site
488223001874	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
488223001875	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488223001876	substrate binding pocket [chemical binding]; other site
488223001877	membrane-bound complex binding site; other site
488223001878	hinge residues; other site
488223001879	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223001880	dimer interface [polypeptide binding]; other site
488223001881	conserved gate region; other site
488223001882	putative PBP binding loops; other site
488223001883	ABC-ATPase subunit interface; other site
488223001884	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
488223001885	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
488223001886	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
488223001887	dimer interface [polypeptide binding]; other site
488223001888	putative anticodon binding site; other site
488223001889	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
488223001890	motif 1; other site
488223001891	active site
488223001892	motif 2; other site
488223001893	motif 3; other site
488223001894	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
488223001895	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
488223001896	teramer interface [polypeptide binding]; other site
488223001897	active site
488223001898	FMN binding site [chemical binding]; other site
488223001899	catalytic residues [active]
488223001900	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
488223001901	substrate binding site [chemical binding]; other site
488223001902	multimerization interface [polypeptide binding]; other site
488223001903	ATP binding site [chemical binding]; other site
488223001904	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
488223001905	thiamine phosphate binding site [chemical binding]; other site
488223001906	active site
488223001907	pyrophosphate binding site [ion binding]; other site
488223001908	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
488223001909	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
488223001910	Walker A/P-loop; other site
488223001911	ATP binding site [chemical binding]; other site
488223001912	ABC transporter; Region: ABC_tran; pfam00005
488223001913	Q-loop/lid; other site
488223001914	ABC transporter signature motif; other site
488223001915	Walker B; other site
488223001916	D-loop; other site
488223001917	H-loop/switch region; other site
488223001918	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223001919	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
488223001920	Walker A/P-loop; other site
488223001921	ATP binding site [chemical binding]; other site
488223001922	Q-loop/lid; other site
488223001923	ABC transporter signature motif; other site
488223001924	Walker B; other site
488223001925	D-loop; other site
488223001926	H-loop/switch region; other site
488223001927	Putative transcription activator [Transcription]; Region: TenA; COG0819
488223001928	Predicted membrane protein [Function unknown]; Region: COG4732
488223001929	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
488223001930	substrate binding site [chemical binding]; other site
488223001931	multimerization interface [polypeptide binding]; other site
488223001932	ATP binding site [chemical binding]; other site
488223001933	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
488223001934	thiamine phosphate binding site [chemical binding]; other site
488223001935	active site
488223001936	pyrophosphate binding site [ion binding]; other site
488223001937	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
488223001938	dimer interface [polypeptide binding]; other site
488223001939	substrate binding site [chemical binding]; other site
488223001940	ATP binding site [chemical binding]; other site
488223001941	Predicted transcriptional regulator [Transcription]; Region: COG3682
488223001942	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
488223001943	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
488223001944	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
488223001945	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
488223001946	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
488223001947	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
488223001948	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
488223001949	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
488223001950	PYR/PP interface [polypeptide binding]; other site
488223001951	dimer interface [polypeptide binding]; other site
488223001952	tetramer interface [polypeptide binding]; other site
488223001953	TPP binding site [chemical binding]; other site
488223001954	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
488223001955	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
488223001956	TPP-binding site [chemical binding]; other site
488223001957	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
488223001958	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
488223001959	active site
488223001960	DDE superfamily endonuclease; Region: DDE_3; pfam13358
488223001961	Homeodomain-like domain; Region: HTH_23; pfam13384
488223001962	Winged helix-turn helix; Region: HTH_29; pfam13551
488223001963	Homeodomain-like domain; Region: HTH_32; pfam13565
488223001964	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
488223001965	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
488223001966	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
488223001967	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
488223001968	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
488223001969	DNA binding residues [nucleotide binding]
488223001970	dimer interface [polypeptide binding]; other site
488223001971	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
488223001972	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
488223001973	putative active site [active]
488223001974	nucleotide binding site [chemical binding]; other site
488223001975	nudix motif; other site
488223001976	putative metal binding site [ion binding]; other site
488223001977	Predicted flavoproteins [General function prediction only]; Region: COG2081
488223001978	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
488223001979	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
488223001980	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
488223001981	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
488223001982	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
488223001983	catalytic motif [active]
488223001984	Zn binding site [ion binding]; other site
488223001985	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488223001986	active site
488223001987	Clp protease; Region: CLP_protease; pfam00574
488223001988	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
488223001989	oligomer interface [polypeptide binding]; other site
488223001990	active site residues [active]
488223001991	hypothetical protein; Provisional; Region: PRK02302
488223001992	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
488223001993	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
488223001994	putative ligand binding site [chemical binding]; other site
488223001995	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488223001996	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
488223001997	TM-ABC transporter signature motif; other site
488223001998	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
488223001999	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
488223002000	TM-ABC transporter signature motif; other site
488223002001	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
488223002002	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
488223002003	Walker A/P-loop; other site
488223002004	ATP binding site [chemical binding]; other site
488223002005	Q-loop/lid; other site
488223002006	ABC transporter signature motif; other site
488223002007	Walker B; other site
488223002008	D-loop; other site
488223002009	H-loop/switch region; other site
488223002010	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
488223002011	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
488223002012	Walker A/P-loop; other site
488223002013	ATP binding site [chemical binding]; other site
488223002014	Q-loop/lid; other site
488223002015	ABC transporter signature motif; other site
488223002016	Walker B; other site
488223002017	D-loop; other site
488223002018	H-loop/switch region; other site
488223002019	FOG: CBS domain [General function prediction only]; Region: COG0517
488223002020	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
488223002021	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
488223002022	peptide chain release factor 2; Region: prfB; TIGR00020
488223002023	PCRF domain; Region: PCRF; pfam03462
488223002024	RF-1 domain; Region: RF-1; pfam00472
488223002025	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
488223002026	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223002027	Walker A/P-loop; other site
488223002028	ATP binding site [chemical binding]; other site
488223002029	Q-loop/lid; other site
488223002030	ABC transporter signature motif; other site
488223002031	Walker B; other site
488223002032	D-loop; other site
488223002033	H-loop/switch region; other site
488223002034	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
488223002035	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
488223002036	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
488223002037	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
488223002038	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
488223002039	active site turn [active]
488223002040	phosphorylation site [posttranslational modification]
488223002041	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
488223002042	HPr interaction site; other site
488223002043	glycerol kinase (GK) interaction site [polypeptide binding]; other site
488223002044	active site
488223002045	phosphorylation site [posttranslational modification]
488223002046	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
488223002047	putative catalytic site [active]
488223002048	putative metal binding site [ion binding]; other site
488223002049	putative phosphate binding site [ion binding]; other site
488223002050	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
488223002051	DEAD-like helicases superfamily; Region: DEXDc; smart00487
488223002052	ATP binding site [chemical binding]; other site
488223002053	Mg++ binding site [ion binding]; other site
488223002054	motif III; other site
488223002055	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488223002056	nucleotide binding region [chemical binding]; other site
488223002057	ATP-binding site [chemical binding]; other site
488223002058	S-adenosylmethionine synthetase; Validated; Region: PRK05250
488223002059	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
488223002060	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
488223002061	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
488223002062	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
488223002063	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
488223002064	active site
488223002065	FMN binding site [chemical binding]; other site
488223002066	substrate binding site [chemical binding]; other site
488223002067	catalytic residues [active]
488223002068	homodimer interface [polypeptide binding]; other site
488223002069	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
488223002070	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
488223002071	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
488223002072	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
488223002073	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
488223002074	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
488223002075	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
488223002076	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
488223002077	FeS/SAM binding site; other site
488223002078	VanZ like family; Region: VanZ; pfam04892
488223002079	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
488223002080	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488223002081	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488223002082	ABC transporter; Region: ABC_tran_2; pfam12848
488223002083	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488223002084	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
488223002085	active site
488223002086	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
488223002087	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
488223002088	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
488223002089	KH domain; Region: KH_4; pfam13083
488223002090	G-X-X-G motif; other site
488223002091	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
488223002092	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
488223002093	RimM N-terminal domain; Region: RimM; pfam01782
488223002094	PRC-barrel domain; Region: PRC; pfam05239
488223002095	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
488223002096	ATP cone domain; Region: ATP-cone; pfam03477
488223002097	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
488223002098	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
488223002099	glutathione reductase; Validated; Region: PRK06116
488223002100	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
488223002101	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
488223002102	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
488223002103	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
488223002104	HlyD family secretion protein; Region: HlyD_3; pfam13437
488223002105	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
488223002106	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
488223002107	Walker A/P-loop; other site
488223002108	ATP binding site [chemical binding]; other site
488223002109	Q-loop/lid; other site
488223002110	ABC transporter signature motif; other site
488223002111	Walker B; other site
488223002112	D-loop; other site
488223002113	H-loop/switch region; other site
488223002114	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
488223002115	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
488223002116	FtsX-like permease family; Region: FtsX; pfam02687
488223002117	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
488223002118	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
488223002119	active site
488223002120	HIGH motif; other site
488223002121	KMSKS motif; other site
488223002122	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
488223002123	tRNA binding surface [nucleotide binding]; other site
488223002124	anticodon binding site; other site
488223002125	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
488223002126	dimer interface [polypeptide binding]; other site
488223002127	putative tRNA-binding site [nucleotide binding]; other site
488223002128	Predicted transcriptional regulators [Transcription]; Region: COG1695
488223002129	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
488223002130	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
488223002131	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
488223002132	active site
488223002133	catalytic tetrad [active]
488223002134	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
488223002135	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
488223002136	classical (c) SDRs; Region: SDR_c; cd05233
488223002137	NAD(P) binding site [chemical binding]; other site
488223002138	active site
488223002139	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
488223002140	nudix motif; other site
488223002141	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
488223002142	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
488223002143	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
488223002144	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
488223002145	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
488223002146	Zn binding site [ion binding]; other site
488223002147	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
488223002148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488223002149	active site
488223002150	phosphorylation site [posttranslational modification]
488223002151	intermolecular recognition site; other site
488223002152	dimerization interface [polypeptide binding]; other site
488223002153	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488223002154	DNA binding site [nucleotide binding]
488223002155	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
488223002156	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
488223002157	dimer interface [polypeptide binding]; other site
488223002158	phosphorylation site [posttranslational modification]
488223002159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223002160	ATP binding site [chemical binding]; other site
488223002161	Mg2+ binding site [ion binding]; other site
488223002162	G-X-G motif; other site
488223002163	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
488223002164	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
488223002165	Peptidase family U32; Region: Peptidase_U32; pfam01136
488223002166	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
488223002167	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
488223002168	active site
488223002169	catalytic site [active]
488223002170	substrate binding site [chemical binding]; other site
488223002171	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488223002172	ATP binding site [chemical binding]; other site
488223002173	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
488223002174	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
488223002175	DJ-1 family protein; Region: not_thiJ; TIGR01383
488223002176	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
488223002177	conserved cys residue [active]
488223002178	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
488223002179	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223002180	motif II; other site
488223002181	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
488223002182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223002183	Mg2+ binding site [ion binding]; other site
488223002184	G-X-G motif; other site
488223002185	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
488223002186	anchoring element; other site
488223002187	dimer interface [polypeptide binding]; other site
488223002188	ATP binding site [chemical binding]; other site
488223002189	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
488223002190	active site
488223002191	putative metal-binding site [ion binding]; other site
488223002192	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
488223002193	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
488223002194	Winged helix-turn helix; Region: HTH_33; pfam13592
488223002195	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
488223002196	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
488223002197	HTH-like domain; Region: HTH_21; pfam13276
488223002198	Integrase core domain; Region: rve; pfam00665
488223002199	Integrase core domain; Region: rve_2; pfam13333
488223002200	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
488223002201	Helix-turn-helix domain; Region: HTH_28; pfam13518
488223002202	Winged helix-turn helix; Region: HTH_29; pfam13551
488223002203	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
488223002204	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223002205	Walker A motif; other site
488223002206	ATP binding site [chemical binding]; other site
488223002207	Walker B motif; other site
488223002208	arginine finger; other site
488223002209	UvrB/uvrC motif; Region: UVR; pfam02151
488223002210	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223002211	Walker A motif; other site
488223002212	ATP binding site [chemical binding]; other site
488223002213	Walker B motif; other site
488223002214	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
488223002215	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
488223002216	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
488223002217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223002218	dimer interface [polypeptide binding]; other site
488223002219	conserved gate region; other site
488223002220	putative PBP binding loops; other site
488223002221	ABC-ATPase subunit interface; other site
488223002222	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
488223002223	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
488223002224	Walker A/P-loop; other site
488223002225	ATP binding site [chemical binding]; other site
488223002226	Q-loop/lid; other site
488223002227	ABC transporter signature motif; other site
488223002228	Walker B; other site
488223002229	D-loop; other site
488223002230	H-loop/switch region; other site
488223002231	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
488223002232	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
488223002233	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
488223002234	homodimer interface [polypeptide binding]; other site
488223002235	NADP binding site [chemical binding]; other site
488223002236	substrate binding site [chemical binding]; other site
488223002237	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
488223002238	putative substrate binding site [chemical binding]; other site
488223002239	putative ATP binding site [chemical binding]; other site
488223002240	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
488223002241	tetramer (dimer of dimers) interface [polypeptide binding]; other site
488223002242	active site
488223002243	dimer interface [polypeptide binding]; other site
488223002244	phosphopentomutase; Provisional; Region: PRK05362
488223002245	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
488223002246	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
488223002247	purine nucleoside phosphorylase; Provisional; Region: PRK08202
488223002248	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
488223002249	nucleophilic elbow; other site
488223002250	catalytic triad; other site
488223002251	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
488223002252	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
488223002253	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
488223002254	topology modulation protein; Provisional; Region: PRK07261
488223002255	AAA domain; Region: AAA_17; pfam13207
488223002256	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
488223002257	pantothenate kinase; Provisional; Region: PRK05439
488223002258	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
488223002259	ATP-binding site [chemical binding]; other site
488223002260	CoA-binding site [chemical binding]; other site
488223002261	Mg2+-binding site [ion binding]; other site
488223002262	Methyltransferase domain; Region: Methyltransf_31; pfam13847
488223002263	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223002264	S-adenosylmethionine binding site [chemical binding]; other site
488223002265	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
488223002266	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
488223002267	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
488223002268	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
488223002269	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
488223002270	intersubunit interface [polypeptide binding]; other site
488223002271	active site
488223002272	catalytic residue [active]
488223002273	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
488223002274	active site
488223002275	catalytic motif [active]
488223002276	Zn binding site [ion binding]; other site
488223002277	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
488223002278	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
488223002279	ligand binding site [chemical binding]; other site
488223002280	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
488223002281	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
488223002282	Walker A/P-loop; other site
488223002283	ATP binding site [chemical binding]; other site
488223002284	Q-loop/lid; other site
488223002285	ABC transporter signature motif; other site
488223002286	Walker B; other site
488223002287	D-loop; other site
488223002288	H-loop/switch region; other site
488223002289	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
488223002290	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488223002291	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
488223002292	TM-ABC transporter signature motif; other site
488223002293	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488223002294	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
488223002295	TM-ABC transporter signature motif; other site
488223002296	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
488223002297	Helix-turn-helix domain; Region: HTH_28; pfam13518
488223002298	HTH-like domain; Region: HTH_21; pfam13276
488223002299	Integrase core domain; Region: rve; pfam00665
488223002300	Integrase core domain; Region: rve_2; pfam13333
488223002301	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
488223002302	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
488223002303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223002304	Mg2+ binding site [ion binding]; other site
488223002305	G-X-G motif; other site
488223002306	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
488223002307	anchoring element; other site
488223002308	dimer interface [polypeptide binding]; other site
488223002309	ATP binding site [chemical binding]; other site
488223002310	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
488223002311	active site
488223002312	putative metal-binding site [ion binding]; other site
488223002313	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
488223002314	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
488223002315	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
488223002316	CAP-like domain; other site
488223002317	active site
488223002318	primary dimer interface [polypeptide binding]; other site
488223002319	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
488223002320	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
488223002321	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
488223002322	homodimer interface [polypeptide binding]; other site
488223002323	substrate-cofactor binding pocket; other site
488223002324	catalytic residue [active]
488223002325	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
488223002326	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
488223002327	Predicted membrane protein [Function unknown]; Region: COG3819
488223002328	Predicted membrane protein [Function unknown]; Region: COG3817
488223002329	Protein of unknown function (DUF979); Region: DUF979; pfam06166
488223002330	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
488223002331	putative substrate binding pocket [chemical binding]; other site
488223002332	AC domain interface; other site
488223002333	catalytic triad [active]
488223002334	AB domain interface; other site
488223002335	interchain disulfide; other site
488223002336	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
488223002337	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
488223002338	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
488223002339	RNA binding site [nucleotide binding]; other site
488223002340	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
488223002341	RNA binding site [nucleotide binding]; other site
488223002342	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
488223002343	RNA binding site [nucleotide binding]; other site
488223002344	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
488223002345	RNA binding site [nucleotide binding]; other site
488223002346	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
488223002347	GAF domain; Region: GAF_2; pfam13185
488223002348	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
488223002349	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223002350	Walker A motif; other site
488223002351	ATP binding site [chemical binding]; other site
488223002352	Walker B motif; other site
488223002353	arginine finger; other site
488223002354	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
488223002355	Protein of unknown function (DUF3272); Region: DUF3272; pfam11676
488223002356	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
488223002357	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
488223002358	Walker A/P-loop; other site
488223002359	ATP binding site [chemical binding]; other site
488223002360	Q-loop/lid; other site
488223002361	ABC transporter signature motif; other site
488223002362	Walker B; other site
488223002363	D-loop; other site
488223002364	H-loop/switch region; other site
488223002365	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
488223002366	FeS assembly protein SufD; Region: sufD; TIGR01981
488223002367	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
488223002368	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
488223002369	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
488223002370	catalytic residue [active]
488223002371	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
488223002372	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
488223002373	trimerization site [polypeptide binding]; other site
488223002374	active site
488223002375	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
488223002376	FeS assembly protein SufB; Region: sufB; TIGR01980
488223002377	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
488223002378	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
488223002379	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
488223002380	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
488223002381	Domain of unknown function DUF20; Region: UPF0118; pfam01594
488223002382	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
488223002383	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
488223002384	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
488223002385	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
488223002386	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
488223002387	putative substrate binding site [chemical binding]; other site
488223002388	putative ATP binding site [chemical binding]; other site
488223002389	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
488223002390	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
488223002391	active site
488223002392	phosphorylation site [posttranslational modification]
488223002393	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
488223002394	active site
488223002395	P-loop; other site
488223002396	phosphorylation site [posttranslational modification]
488223002397	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
488223002398	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
488223002399	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
488223002400	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
488223002401	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
488223002402	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
488223002403	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
488223002404	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
488223002405	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
488223002406	catalytic residue [active]
488223002407	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
488223002408	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
488223002409	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
488223002410	Ligand Binding Site [chemical binding]; other site
488223002411	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
488223002412	Putative esterase; Region: Esterase; pfam00756
488223002413	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
488223002414	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
488223002415	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
488223002416	HsdM N-terminal domain; Region: HsdM_N; pfam12161
488223002417	Methyltransferase domain; Region: Methyltransf_26; pfam13659
488223002418	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
488223002419	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
488223002420	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
488223002421	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
488223002422	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
488223002423	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
488223002424	active site
488223002425	catalytic residues [active]
488223002426	DNA binding site [nucleotide binding]
488223002427	Int/Topo IB signature motif; other site
488223002428	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
488223002429	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
488223002430	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
488223002431	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
488223002432	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488223002433	ATP binding site [chemical binding]; other site
488223002434	putative Mg++ binding site [ion binding]; other site
488223002435	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
488223002436	Arginine repressor [Transcription]; Region: ArgR; COG1438
488223002437	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
488223002438	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
488223002439	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
488223002440	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
488223002441	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
488223002442	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
488223002443	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
488223002444	active site
488223002445	PHP Thumb interface [polypeptide binding]; other site
488223002446	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
488223002447	generic binding surface II; other site
488223002448	generic binding surface I; other site
488223002449	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
488223002450	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
488223002451	active site
488223002452	ADP/pyrophosphate binding site [chemical binding]; other site
488223002453	dimerization interface [polypeptide binding]; other site
488223002454	allosteric effector site; other site
488223002455	fructose-1,6-bisphosphate binding site; other site
488223002456	pyruvate kinase; Provisional; Region: PRK05826
488223002457	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
488223002458	domain interfaces; other site
488223002459	active site
488223002460	Domain of unknown function (DUF4300); Region: DUF4300; pfam14133
488223002461	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
488223002462	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
488223002463	Predicted membrane protein [Function unknown]; Region: COG3689
488223002464	Predicted permeases [General function prediction only]; Region: COG0701
488223002465	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
488223002466	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
488223002467	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
488223002468	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
488223002469	RNA binding site [nucleotide binding]; other site
488223002470	SprT homologues; Region: SprT; cl01182
488223002471	hypothetical protein; Provisional; Region: PRK04351
488223002472	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
488223002473	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
488223002474	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
488223002475	Walker A/P-loop; other site
488223002476	ATP binding site [chemical binding]; other site
488223002477	Q-loop/lid; other site
488223002478	ABC transporter signature motif; other site
488223002479	Walker B; other site
488223002480	D-loop; other site
488223002481	H-loop/switch region; other site
488223002482	FtsX-like permease family; Region: FtsX; pfam02687
488223002483	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
488223002484	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
488223002485	Helix-turn-helix domain; Region: HTH_38; pfam13936
488223002486	Integrase core domain; Region: rve; pfam00665
488223002487	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
488223002488	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
488223002489	homodimer interface [polypeptide binding]; other site
488223002490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488223002491	catalytic residue [active]
488223002492	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
488223002493	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
488223002494	Transposase; Region: DEDD_Tnp_IS110; pfam01548
488223002495	spermidine synthase; Provisional; Region: PRK00811
488223002496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223002497	S-adenosylmethionine binding site [chemical binding]; other site
488223002498	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
488223002499	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488
488223002500	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
488223002501	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
488223002502	dimer interface [polypeptide binding]; other site
488223002503	active site
488223002504	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
488223002505	catalytic residues [active]
488223002506	substrate binding site [chemical binding]; other site
488223002507	agmatine deiminase; Provisional; Region: PRK13551
488223002508	agmatine deiminase; Region: agmatine_aguA; TIGR03380
488223002509	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
488223002510	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
488223002511	putative active site; other site
488223002512	catalytic triad [active]
488223002513	putative dimer interface [polypeptide binding]; other site
488223002514	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223002515	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
488223002516	active site
488223002517	motif I; other site
488223002518	motif II; other site
488223002519	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223002520	CAAX protease self-immunity; Region: Abi; pfam02517
488223002521	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
488223002522	Transcriptional regulator [Transcription]; Region: LysR; COG0583
488223002523	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
488223002524	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
488223002525	dimerization interface [polypeptide binding]; other site
488223002526	lipoprotein signal peptidase; Provisional; Region: PRK14797
488223002527	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
488223002528	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
488223002529	RNA binding surface [nucleotide binding]; other site
488223002530	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
488223002531	active site
488223002532	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
488223002533	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
488223002534	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
488223002535	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
488223002536	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
488223002537	nucleotide binding site [chemical binding]; other site
488223002538	homotetrameric interface [polypeptide binding]; other site
488223002539	putative phosphate binding site [ion binding]; other site
488223002540	putative allosteric binding site; other site
488223002541	PUA domain; Region: PUA; pfam01472
488223002542	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
488223002543	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
488223002544	putative catalytic cysteine [active]
488223002545	pyrroline-5-carboxylate reductase; Region: PLN02688
488223002546	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
488223002547	thymidylate kinase; Validated; Region: tmk; PRK00698
488223002548	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
488223002549	TMP-binding site; other site
488223002550	ATP-binding site [chemical binding]; other site
488223002551	DNA polymerase III subunit delta'; Validated; Region: PRK07276
488223002552	DNA polymerase III subunit delta'; Validated; Region: PRK08485
488223002553	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
488223002554	Predicted methyltransferases [General function prediction only]; Region: COG0313
488223002555	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
488223002556	putative SAM binding site [chemical binding]; other site
488223002557	putative homodimer interface [polypeptide binding]; other site
488223002558	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
488223002559	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
488223002560	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
488223002561	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
488223002562	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
488223002563	Glucose inhibited division protein A; Region: GIDA; pfam01134
488223002564	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
488223002565	putative nucleotide binding site [chemical binding]; other site
488223002566	uridine monophosphate binding site [chemical binding]; other site
488223002567	homohexameric interface [polypeptide binding]; other site
488223002568	ribosome recycling factor; Reviewed; Region: frr; PRK00083
488223002569	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
488223002570	hinge region; other site
488223002571	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
488223002572	S1 domain; Region: S1_2; pfam13509
488223002573	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
488223002574	hypothetical protein; Provisional; Region: PRK13672
488223002575	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
488223002576	PhoH-like protein; Region: PhoH; pfam02562
488223002577	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
488223002578	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488223002579	Coenzyme A binding pocket [chemical binding]; other site
488223002580	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
488223002581	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
488223002582	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
488223002583	SLBB domain; Region: SLBB; pfam10531
488223002584	comEA protein; Region: comE; TIGR01259
488223002585	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
488223002586	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
488223002587	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
488223002588	Competence protein; Region: Competence; pfam03772
488223002589	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
488223002590	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
488223002591	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13541
488223002592	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
488223002593	Walker A/P-loop; other site
488223002594	ATP binding site [chemical binding]; other site
488223002595	Q-loop/lid; other site
488223002596	ABC transporter signature motif; other site
488223002597	Walker B; other site
488223002598	D-loop; other site
488223002599	H-loop/switch region; other site
488223002600	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
488223002601	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
488223002602	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
488223002603	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
488223002604	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
488223002605	23S rRNA binding site [nucleotide binding]; other site
488223002606	L21 binding site [polypeptide binding]; other site
488223002607	L13 binding site [polypeptide binding]; other site
488223002608	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
488223002609	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
488223002610	dimer interface [polypeptide binding]; other site
488223002611	active site
488223002612	metal binding site [ion binding]; metal-binding site
488223002613	glutathione binding site [chemical binding]; other site
488223002614	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
488223002615	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
488223002616	FAD binding pocket [chemical binding]; other site
488223002617	FAD binding motif [chemical binding]; other site
488223002618	phosphate binding motif [ion binding]; other site
488223002619	beta-alpha-beta structure motif; other site
488223002620	NAD binding pocket [chemical binding]; other site
488223002621	Iron coordination center [ion binding]; other site
488223002622	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
488223002623	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
488223002624	heterodimer interface [polypeptide binding]; other site
488223002625	active site
488223002626	FMN binding site [chemical binding]; other site
488223002627	homodimer interface [polypeptide binding]; other site
488223002628	substrate binding site [chemical binding]; other site
488223002629	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
488223002630	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
488223002631	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
488223002632	Domain of unknown function (DUF814); Region: DUF814; pfam05670
488223002633	metal-binding heat shock protein; Provisional; Region: PRK00016
488223002634	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
488223002635	GTPase Era; Reviewed; Region: era; PRK00089
488223002636	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
488223002637	G1 box; other site
488223002638	GTP/Mg2+ binding site [chemical binding]; other site
488223002639	Switch I region; other site
488223002640	G2 box; other site
488223002641	Switch II region; other site
488223002642	G3 box; other site
488223002643	G4 box; other site
488223002644	G5 box; other site
488223002645	KH domain; Region: KH_2; pfam07650
488223002646	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
488223002647	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
488223002648	DNA binding site [nucleotide binding]
488223002649	catalytic residue [active]
488223002650	H2TH interface [polypeptide binding]; other site
488223002651	putative catalytic residues [active]
488223002652	turnover-facilitating residue; other site
488223002653	intercalation triad [nucleotide binding]; other site
488223002654	8OG recognition residue [nucleotide binding]; other site
488223002655	putative reading head residues; other site
488223002656	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
488223002657	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
488223002658	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
488223002659	dephospho-CoA kinase; Region: TIGR00152
488223002660	CoA-binding site [chemical binding]; other site
488223002661	ATP-binding [chemical binding]; other site
488223002662	drug efflux system protein MdtG; Provisional; Region: PRK09874
488223002663	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488223002664	putative substrate translocation pore; other site
488223002665	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
488223002666	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
488223002667	ribonuclease R; Region: RNase_R; TIGR02063
488223002668	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
488223002669	RNB domain; Region: RNB; pfam00773
488223002670	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
488223002671	RNA binding site [nucleotide binding]; other site
488223002672	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
488223002673	SmpB-tmRNA interface; other site
488223002674	tellurite resistance protein TehB; Provisional; Region: PRK12335
488223002675	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
488223002676	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223002677	S-adenosylmethionine binding site [chemical binding]; other site
488223002678	Competence protein CoiA-like family, contains a predicted nuclease    domain [General function prediction only]; Region: CoiA; COG4469
488223002679	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
488223002680	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
488223002681	active site
488223002682	Zn binding site [ion binding]; other site
488223002683	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
488223002684	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223002685	S-adenosylmethionine binding site [chemical binding]; other site
488223002686	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
488223002687	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
488223002688	Integrase core domain; Region: rve; pfam00665
488223002689	Integrase core domain; Region: rve_2; pfam13333
488223002690	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
488223002691	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
488223002692	catalytic core [active]
488223002693	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
488223002694	putative deacylase active site [active]
488223002695	Predicted membrane protein [Function unknown]; Region: COG2035
488223002696	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
488223002697	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
488223002698	active site
488223002699	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
488223002700	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
488223002701	Substrate binding site; other site
488223002702	Mg++ binding site; other site
488223002703	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
488223002704	active site
488223002705	substrate binding site [chemical binding]; other site
488223002706	CoA binding site [chemical binding]; other site
488223002707	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
488223002708	dimer interface [polypeptide binding]; other site
488223002709	ADP-ribose binding site [chemical binding]; other site
488223002710	active site
488223002711	nudix motif; other site
488223002712	metal binding site [ion binding]; metal-binding site
488223002713	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
488223002714	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
488223002715	MarR family; Region: MarR_2; cl17246
488223002716	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
488223002717	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
488223002718	active site
488223002719	catalytic site [active]
488223002720	substrate binding site [chemical binding]; other site
488223002721	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
488223002722	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
488223002723	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
488223002724	putative active site [active]
488223002725	catalytic site [active]
488223002726	putative metal binding site [ion binding]; other site
488223002727	Helix-turn-helix domain; Region: HTH_28; pfam13518
488223002728	Winged helix-turn helix; Region: HTH_29; pfam13551
488223002729	DDE superfamily endonuclease; Region: DDE_3; pfam13358
488223002730	Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases; Region: TM_EGFR-like; cl17045
488223002731	dimer interface [polypeptide binding]; other site
488223002732	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
488223002733	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
488223002734	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
488223002735	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
488223002736	catalytic residues [active]
488223002737	amino acid transporter; Region: 2A0306; TIGR00909
488223002738	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
488223002739	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
488223002740	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
488223002741	metal binding site [ion binding]; metal-binding site
488223002742	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
488223002743	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223002744	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223002745	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223002746	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
488223002747	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223002748	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223002749	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223002750	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223002751	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223002752	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223002753	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223002754	peptidase T; Region: peptidase-T; TIGR01882
488223002755	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
488223002756	metal binding site [ion binding]; metal-binding site
488223002757	dimer interface [polypeptide binding]; other site
488223002758	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
488223002759	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
488223002760	Predicted membrane protein [Function unknown]; Region: COG2246
488223002761	GtrA-like protein; Region: GtrA; pfam04138
488223002762	Predicted membrane protein [Function unknown]; Region: COG4708
488223002763	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
488223002764	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
488223002765	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
488223002766	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
488223002767	dimer interface [polypeptide binding]; other site
488223002768	active site
488223002769	catalytic residue [active]
488223002770	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
488223002771	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
488223002772	trmE is a tRNA modification GTPase; Region: trmE; cd04164
488223002773	G1 box; other site
488223002774	GTP/Mg2+ binding site [chemical binding]; other site
488223002775	Switch I region; other site
488223002776	G2 box; other site
488223002777	Switch II region; other site
488223002778	G3 box; other site
488223002779	G4 box; other site
488223002780	G5 box; other site
488223002781	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
488223002782	4-oxalocrotonate tautomerase; Provisional; Region: PRK02289
488223002783	active site 1 [active]
488223002784	dimer interface [polypeptide binding]; other site
488223002785	hexamer interface [polypeptide binding]; other site
488223002786	active site 2 [active]
488223002787	thymidine kinase; Provisional; Region: PRK04296
488223002788	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
488223002789	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
488223002790	Coenzyme A binding pocket [chemical binding]; other site
488223002791	peptide chain release factor 1; Validated; Region: prfA; PRK00591
488223002792	This domain is found in peptide chain release factors; Region: PCRF; smart00937
488223002793	RF-1 domain; Region: RF-1; pfam00472
488223002794	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
488223002795	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223002796	S-adenosylmethionine binding site [chemical binding]; other site
488223002797	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
488223002798	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
488223002799	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488223002800	Coenzyme A binding pocket [chemical binding]; other site
488223002801	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
488223002802	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
488223002803	dimer interface [polypeptide binding]; other site
488223002804	active site
488223002805	glycine-pyridoxal phosphate binding site [chemical binding]; other site
488223002806	folate binding site [chemical binding]; other site
488223002807	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
488223002808	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
488223002809	Lysozyme-like; Region: Lysozyme_like; pfam13702
488223002810	catalytic residue [active]
488223002811	Predicted secreted protein [Function unknown]; Region: COG4086
488223002812	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
488223002813	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
488223002814	TRAM domain; Region: TRAM; cl01282
488223002815	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223002816	S-adenosylmethionine binding site [chemical binding]; other site
488223002817	Predicted transcriptional regulator [Transcription]; Region: COG3655
488223002818	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
488223002819	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
488223002820	siderophore binding site; other site
488223002821	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
488223002822	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
488223002823	ABC-ATPase subunit  interface; other site
488223002824	dimer interface [polypeptide binding]; other site
488223002825	putative PBP binding regions; other site
488223002826	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
488223002827	ABC-ATPase subunit  interface; other site
488223002828	dimer interface [polypeptide binding]; other site
488223002829	putative PBP binding regions; other site
488223002830	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
488223002831	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
488223002832	Walker A/P-loop; other site
488223002833	ATP binding site [chemical binding]; other site
488223002834	Q-loop/lid; other site
488223002835	ABC transporter signature motif; other site
488223002836	Walker B; other site
488223002837	D-loop; other site
488223002838	H-loop/switch region; other site
488223002839	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
488223002840	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
488223002841	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
488223002842	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
488223002843	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
488223002844	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488223002845	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223002846	non-specific DNA binding site [nucleotide binding]; other site
488223002847	salt bridge; other site
488223002848	sequence-specific DNA binding site [nucleotide binding]; other site
488223002849	Zeta toxin; Region: Zeta_toxin; pfam06414
488223002850	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
488223002851	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
488223002852	AAA domain; Region: AAA_21; pfam13304
488223002853	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223002854	ABC transporter signature motif; other site
488223002855	Walker B; other site
488223002856	D-loop; other site
488223002857	H-loop/switch region; other site
488223002858	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
488223002859	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
488223002860	NAD binding site [chemical binding]; other site
488223002861	UDP-glucose 4-epimerase; Region: PLN02240
488223002862	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
488223002863	NAD binding site [chemical binding]; other site
488223002864	homodimer interface [polypeptide binding]; other site
488223002865	active site
488223002866	substrate binding site [chemical binding]; other site
488223002867	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
488223002868	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488223002869	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223002870	sequence-specific DNA binding site [nucleotide binding]; other site
488223002871	salt bridge; other site
488223002872	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
488223002873	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
488223002874	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
488223002875	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
488223002876	T-box leader; cis-reg00001
488223002877	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
488223002878	zinc binding site [ion binding]; other site
488223002879	putative ligand binding site [chemical binding]; other site
488223002880	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
488223002881	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
488223002882	TM-ABC transporter signature motif; other site
488223002883	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
488223002884	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223002885	Walker A/P-loop; other site
488223002886	ATP binding site [chemical binding]; other site
488223002887	Q-loop/lid; other site
488223002888	ABC transporter signature motif; other site
488223002889	Walker B; other site
488223002890	D-loop; other site
488223002891	H-loop/switch region; other site
488223002892	DNA primase; Validated; Region: dnaG; PRK05667
488223002893	CHC2 zinc finger; Region: zf-CHC2; pfam01807
488223002894	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
488223002895	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
488223002896	active site
488223002897	metal binding site [ion binding]; metal-binding site
488223002898	interdomain interaction site; other site
488223002899	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
488223002900	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
488223002901	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
488223002902	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
488223002903	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
488223002904	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
488223002905	DNA binding residues [nucleotide binding]
488223002906	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
488223002907	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488223002908	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
488223002909	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488223002910	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
488223002911	putative ADP-binding pocket [chemical binding]; other site
488223002912	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
488223002913	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
488223002914	GTPase CgtA; Reviewed; Region: obgE; PRK12297
488223002915	GTP1/OBG; Region: GTP1_OBG; pfam01018
488223002916	Obg GTPase; Region: Obg; cd01898
488223002917	G1 box; other site
488223002918	GTP/Mg2+ binding site [chemical binding]; other site
488223002919	Switch I region; other site
488223002920	G2 box; other site
488223002921	G3 box; other site
488223002922	Switch II region; other site
488223002923	G4 box; other site
488223002924	G5 box; other site
488223002925	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
488223002926	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
488223002927	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
488223002928	hinge; other site
488223002929	active site
488223002930	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
488223002931	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
488223002932	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
488223002933	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
488223002934	DNA-binding site [nucleotide binding]; DNA binding site
488223002935	DRTGG domain; Region: DRTGG; pfam07085
488223002936	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
488223002937	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
488223002938	active site 2 [active]
488223002939	active site 1 [active]
488223002940	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
488223002941	active site
488223002942	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
488223002943	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
488223002944	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
488223002945	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
488223002946	Part of AAA domain; Region: AAA_19; pfam13245
488223002947	Family description; Region: UvrD_C_2; pfam13538
488223002948	hypothetical protein; Reviewed; Region: PRK00024
488223002949	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
488223002950	MPN+ (JAMM) motif; other site
488223002951	Zinc-binding site [ion binding]; other site
488223002952	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
488223002953	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
488223002954	catalytic triad [active]
488223002955	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
488223002956	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
488223002957	CoA binding domain; Region: CoA_binding; pfam02629
488223002958	Putative amino acid metabolism; Region: DUF1831; pfam08866
488223002959	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
488223002960	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
488223002961	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
488223002962	catalytic residue [active]
488223002963	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
488223002964	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
488223002965	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488223002966	active site
488223002967	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
488223002968	putative active site [active]
488223002969	putative metal binding residues [ion binding]; other site
488223002970	signature motif; other site
488223002971	putative triphosphate binding site [ion binding]; other site
488223002972	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
488223002973	synthetase active site [active]
488223002974	NTP binding site [chemical binding]; other site
488223002975	metal binding site [ion binding]; metal-binding site
488223002976	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
488223002977	ATP-NAD kinase; Region: NAD_kinase; pfam01513
488223002978	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
488223002979	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
488223002980	RNA binding surface [nucleotide binding]; other site
488223002981	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
488223002982	active site
488223002983	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
488223002984	hypothetical protein; Validated; Region: PRK00153
488223002985	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
488223002986	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
488223002987	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
488223002988	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
488223002989	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
488223002990	active site
488223002991	Riboflavin kinase; Region: Flavokinase; smart00904
488223002992	Uncharacterized conserved protein [Function unknown]; Region: COG1284
488223002993	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
488223002994	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
488223002995	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
488223002996	EDD domain protein, DegV family; Region: DegV; TIGR00762
488223002997	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
488223002998	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
488223002999	IHF dimer interface [polypeptide binding]; other site
488223003000	IHF - DNA interface [nucleotide binding]; other site
488223003001	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
488223003002	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488223003003	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488223003004	ABC transporter; Region: ABC_tran_2; pfam12848
488223003005	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488223003006	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223003007	non-specific DNA binding site [nucleotide binding]; other site
488223003008	salt bridge; other site
488223003009	sequence-specific DNA binding site [nucleotide binding]; other site
488223003010	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
488223003011	H+ Antiporter protein; Region: 2A0121; TIGR00900
488223003012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488223003013	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
488223003014	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
488223003015	nucleotide binding pocket [chemical binding]; other site
488223003016	K-X-D-G motif; other site
488223003017	catalytic site [active]
488223003018	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
488223003019	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
488223003020	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
488223003021	Dimer interface [polypeptide binding]; other site
488223003022	BRCT sequence motif; other site
488223003023	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227
488223003024	pullulanase, type I; Region: pulA_typeI; TIGR02104
488223003025	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
488223003026	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
488223003027	Ca binding site [ion binding]; other site
488223003028	active site
488223003029	catalytic site [active]
488223003030	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
488223003031	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
488223003032	tetrameric interface [polypeptide binding]; other site
488223003033	activator binding site; other site
488223003034	NADP binding site [chemical binding]; other site
488223003035	substrate binding site [chemical binding]; other site
488223003036	catalytic residues [active]
488223003037	glycogen branching enzyme; Provisional; Region: PRK12313
488223003038	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
488223003039	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
488223003040	active site
488223003041	catalytic site [active]
488223003042	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
488223003043	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
488223003044	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
488223003045	ligand binding site; other site
488223003046	oligomer interface; other site
488223003047	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
488223003048	dimer interface [polypeptide binding]; other site
488223003049	N-terminal domain interface [polypeptide binding]; other site
488223003050	sulfate 1 binding site; other site
488223003051	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
488223003052	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
488223003053	active site
488223003054	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
488223003055	dimer interface [polypeptide binding]; other site
488223003056	N-terminal domain interface [polypeptide binding]; other site
488223003057	sulfate 1 binding site; other site
488223003058	glycogen synthase; Provisional; Region: glgA; PRK00654
488223003059	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
488223003060	ADP-binding pocket [chemical binding]; other site
488223003061	homodimer interface [polypeptide binding]; other site
488223003062	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
488223003063	Uncharacterized conserved protein [Function unknown]; Region: COG5506
488223003064	enolase; Provisional; Region: eno; PRK00077
488223003065	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
488223003066	dimer interface [polypeptide binding]; other site
488223003067	metal binding site [ion binding]; metal-binding site
488223003068	substrate binding pocket [chemical binding]; other site
488223003069	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488223003070	DNA binding site [nucleotide binding]
488223003071	active site
488223003072	Int/Topo IB signature motif; other site
488223003073	Transposase; Region: HTH_Tnp_IS630; pfam01710
488223003074	Helix-turn-helix domain; Region: HTH_28; pfam13518
488223003075	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
488223003076	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
488223003077	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
488223003078	Part of AAA domain; Region: AAA_19; pfam13245
488223003079	Family description; Region: UvrD_C_2; pfam13538
488223003080	Family description; Region: UvrD_C_2; pfam13538
488223003081	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
488223003082	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
488223003083	G5 domain; Region: G5; pfam07501
488223003084	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
488223003085	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
488223003086	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
488223003087	G5 domain; Region: G5; pfam07501
488223003088	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
488223003089	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
488223003090	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
488223003091	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
488223003092	cofactor binding site; other site
488223003093	DNA binding site [nucleotide binding]
488223003094	substrate interaction site [chemical binding]; other site
488223003095	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
488223003096	Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393
488223003097	ArsC family; Region: ArsC; pfam03960
488223003098	CAAX protease self-immunity; Region: Abi; pfam02517
488223003099	DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920
488223003100	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
488223003101	Int/Topo IB signature motif; other site
488223003102	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
488223003103	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
488223003104	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
488223003105	DNA binding residues [nucleotide binding]
488223003106	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223003107	non-specific DNA binding site [nucleotide binding]; other site
488223003108	salt bridge; other site
488223003109	sequence-specific DNA binding site [nucleotide binding]; other site
488223003110	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
488223003111	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
488223003112	G1 box; other site
488223003113	putative GEF interaction site [polypeptide binding]; other site
488223003114	GTP/Mg2+ binding site [chemical binding]; other site
488223003115	Switch I region; other site
488223003116	G2 box; other site
488223003117	G3 box; other site
488223003118	Switch II region; other site
488223003119	G4 box; other site
488223003120	G5 box; other site
488223003121	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
488223003122	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
488223003123	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
488223003124	tetracycline resistance determinant leader peptide; Provisional; Region: PRK14751
488223003125	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
488223003126	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
488223003127	N-acetyl-D-glucosamine binding site [chemical binding]; other site
488223003128	catalytic residue [active]
488223003129	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
488223003130	NlpC/P60 family; Region: NLPC_P60; pfam00877
488223003131	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
488223003132	Haemolysin-III related; Region: HlyIII; cl03831
488223003133	AAA-like domain; Region: AAA_10; pfam12846
488223003134	TcpE family; Region: TcpE; pfam12648
488223003135	Antirestriction protein (ArdA); Region: ArdA; pfam07275
488223003136	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223003137	non-specific DNA binding site [nucleotide binding]; other site
488223003138	salt bridge; other site
488223003139	sequence-specific DNA binding site [nucleotide binding]; other site
488223003140	Replication initiation factor; Region: Rep_trans; pfam02486
488223003141	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
488223003142	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223003143	Walker A motif; other site
488223003144	ATP binding site [chemical binding]; other site
488223003145	Walker B motif; other site
488223003146	arginine finger; other site
488223003147	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
488223003148	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
488223003149	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
488223003150	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
488223003151	Walker A motif; other site
488223003152	ATP binding site [chemical binding]; other site
488223003153	Walker B motif; other site
488223003154	PrgI family protein; Region: PrgI; pfam12666
488223003155	AAA-like domain; Region: AAA_10; pfam12846
488223003156	Peptidase family M23; Region: Peptidase_M23; pfam01551
488223003157	CHAP domain; Region: CHAP; pfam05257
488223003158	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
488223003159	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
488223003160	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223003161	S-adenosylmethionine binding site [chemical binding]; other site
488223003162	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
488223003163	DEAD-like helicases superfamily; Region: DEXDc; smart00487
488223003164	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
488223003165	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
488223003166	helicase superfamily c-terminal domain; Region: HELICc; smart00490
488223003167	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
488223003168	Toprim-like; Region: Toprim_2; pfam13155
488223003169	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
488223003170	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488223003171	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223003172	non-specific DNA binding site [nucleotide binding]; other site
488223003173	salt bridge; other site
488223003174	sequence-specific DNA binding site [nucleotide binding]; other site
488223003175	Zeta toxin; Region: Zeta_toxin; pfam06414
488223003176	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
488223003177	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223003178	non-specific DNA binding site [nucleotide binding]; other site
488223003179	salt bridge; other site
488223003180	sequence-specific DNA binding site [nucleotide binding]; other site
488223003181	Predicted transcriptional regulator [Transcription]; Region: COG2932
488223003182	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
488223003183	Catalytic site [active]
488223003184	DNA polymerase IV; Reviewed; Region: PRK03103
488223003185	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
488223003186	active site
488223003187	DNA binding site [nucleotide binding]
488223003188	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
488223003189	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
488223003190	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488223003191	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223003192	non-specific DNA binding site [nucleotide binding]; other site
488223003193	salt bridge; other site
488223003194	sequence-specific DNA binding site [nucleotide binding]; other site
488223003195	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
488223003196	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
488223003197	Int/Topo IB signature motif; other site
488223003198	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
488223003199	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
488223003200	GTP/Mg2+ binding site [chemical binding]; other site
488223003201	G4 box; other site
488223003202	G5 box; other site
488223003203	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
488223003204	G1 box; other site
488223003205	G1 box; other site
488223003206	GTP/Mg2+ binding site [chemical binding]; other site
488223003207	Switch I region; other site
488223003208	G2 box; other site
488223003209	G2 box; other site
488223003210	G3 box; other site
488223003211	G3 box; other site
488223003212	Switch II region; other site
488223003213	Switch II region; other site
488223003214	G5 box; other site
488223003215	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
488223003216	RNA/DNA hybrid binding site [nucleotide binding]; other site
488223003217	active site
488223003218	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
488223003219	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
488223003220	Cl- selectivity filter; other site
488223003221	Cl- binding residues [ion binding]; other site
488223003222	pore gating glutamate residue; other site
488223003223	dimer interface [polypeptide binding]; other site
488223003224	H+/Cl- coupling transport residue; other site
488223003225	TrkA-C domain; Region: TrkA_C; pfam02080
488223003226	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
488223003227	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
488223003228	active site
488223003229	DNA binding site [nucleotide binding]
488223003230	Int/Topo IB signature motif; other site
488223003231	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
488223003232	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
488223003233	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
488223003234	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
488223003235	E3 interaction surface; other site
488223003236	lipoyl attachment site [posttranslational modification]; other site
488223003237	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
488223003238	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
488223003239	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
488223003240	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
488223003241	dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843
488223003242	e3 binding domain; Region: E3_binding; pfam02817
488223003243	e3 binding domain; Region: E3_binding; pfam02817
488223003244	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
488223003245	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
488223003246	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
488223003247	alpha subunit interface [polypeptide binding]; other site
488223003248	TPP binding site [chemical binding]; other site
488223003249	heterodimer interface [polypeptide binding]; other site
488223003250	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
488223003251	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
488223003252	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
488223003253	tetramer interface [polypeptide binding]; other site
488223003254	TPP-binding site [chemical binding]; other site
488223003255	heterodimer interface [polypeptide binding]; other site
488223003256	phosphorylation loop region [posttranslational modification]
488223003257	multidrug efflux protein; Reviewed; Region: PRK01766
488223003258	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
488223003259	cation binding site [ion binding]; other site
488223003260	dihydroorotase; Validated; Region: pyrC; PRK09357
488223003261	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
488223003262	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
488223003263	active site
488223003264	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
488223003265	putative active site [active]
488223003266	nucleotide binding site [chemical binding]; other site
488223003267	nudix motif; other site
488223003268	putative metal binding site [ion binding]; other site
488223003269	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
488223003270	ligand binding site [chemical binding]; other site
488223003271	active site
488223003272	UGI interface [polypeptide binding]; other site
488223003273	catalytic site [active]
488223003274	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
488223003275	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223003276	motif II; other site
488223003277	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
488223003278	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
488223003279	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223003280	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223003281	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223003282	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
488223003283	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223003284	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223003285	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
488223003286	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
488223003287	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
488223003288	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
488223003289	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
488223003290	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
488223003291	dimerization domain swap beta strand [polypeptide binding]; other site
488223003292	regulatory protein interface [polypeptide binding]; other site
488223003293	active site
488223003294	regulatory phosphorylation site [posttranslational modification]; other site
488223003295	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
488223003296	catalytic residues [active]
488223003297	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
488223003298	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
488223003299	Class I ribonucleotide reductase; Region: RNR_I; cd01679
488223003300	active site
488223003301	dimer interface [polypeptide binding]; other site
488223003302	catalytic residues [active]
488223003303	effector binding site; other site
488223003304	R2 peptide binding site; other site
488223003305	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
488223003306	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
488223003307	dimer interface [polypeptide binding]; other site
488223003308	putative radical transfer pathway; other site
488223003309	diiron center [ion binding]; other site
488223003310	tyrosyl radical; other site
488223003311	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
488223003312	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
488223003313	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
488223003314	Protein of unknown function (DUF3884); Region: DUF3884; pfam13024
488223003315	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
488223003316	beta-galactosidase; Region: BGL; TIGR03356
488223003317	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
488223003318	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
488223003319	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
488223003320	active site
488223003321	P-loop; other site
488223003322	phosphorylation site [posttranslational modification]
488223003323	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
488223003324	methionine cluster; other site
488223003325	active site
488223003326	phosphorylation site [posttranslational modification]
488223003327	metal binding site [ion binding]; metal-binding site
488223003328	CAT RNA binding domain; Region: CAT_RBD; smart01061
488223003329	transcriptional antiterminator BglG; Provisional; Region: PRK09772
488223003330	PRD domain; Region: PRD; pfam00874
488223003331	PRD domain; Region: PRD; pfam00874
488223003332	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
488223003333	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
488223003334	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
488223003335	putative substrate binding site [chemical binding]; other site
488223003336	putative ATP binding site [chemical binding]; other site
488223003337	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
488223003338	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
488223003339	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
488223003340	catalytic residues [active]
488223003341	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
488223003342	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
488223003343	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
488223003344	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
488223003345	active site
488223003346	P-loop; other site
488223003347	phosphorylation site [posttranslational modification]
488223003348	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
488223003349	active site
488223003350	phosphorylation site [posttranslational modification]
488223003351	GTP-binding protein LepA; Provisional; Region: PRK05433
488223003352	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
488223003353	G1 box; other site
488223003354	putative GEF interaction site [polypeptide binding]; other site
488223003355	GTP/Mg2+ binding site [chemical binding]; other site
488223003356	Switch I region; other site
488223003357	G2 box; other site
488223003358	G3 box; other site
488223003359	Switch II region; other site
488223003360	G4 box; other site
488223003361	G5 box; other site
488223003362	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
488223003363	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
488223003364	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
488223003365	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
488223003366	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
488223003367	active site
488223003368	metal binding site [ion binding]; metal-binding site
488223003369	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
488223003370	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
488223003371	Walker A/P-loop; other site
488223003372	ATP binding site [chemical binding]; other site
488223003373	Q-loop/lid; other site
488223003374	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
488223003375	ABC transporter signature motif; other site
488223003376	Walker B; other site
488223003377	D-loop; other site
488223003378	H-loop/switch region; other site
488223003379	Arginine repressor [Transcription]; Region: ArgR; COG1438
488223003380	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
488223003381	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
488223003382	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
488223003383	S4 RNA-binding domain; Region: S4; smart00363
488223003384	RNA binding surface [nucleotide binding]; other site
488223003385	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
488223003386	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
488223003387	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
488223003388	substrate binding pocket [chemical binding]; other site
488223003389	chain length determination region; other site
488223003390	substrate-Mg2+ binding site; other site
488223003391	catalytic residues [active]
488223003392	aspartate-rich region 1; other site
488223003393	active site lid residues [active]
488223003394	aspartate-rich region 2; other site
488223003395	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
488223003396	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
488223003397	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
488223003398	generic binding surface II; other site
488223003399	generic binding surface I; other site
488223003400	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
488223003401	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
488223003402	Sugar specificity; other site
488223003403	Pyrimidine base specificity; other site
488223003404	ATP-binding site [chemical binding]; other site
488223003405	Enterocin A Immunity; Region: EntA_Immun; pfam08951
488223003406	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
488223003407	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
488223003408	RNA binding site [nucleotide binding]; other site
488223003409	active site
488223003410	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
488223003411	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
488223003412	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
488223003413	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
488223003414	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
488223003415	active site
488223003416	catalytic site [active]
488223003417	DNA gyrase subunit A; Validated; Region: PRK05560
488223003418	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
488223003419	CAP-like domain; other site
488223003420	active site
488223003421	primary dimer interface [polypeptide binding]; other site
488223003422	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
488223003423	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
488223003424	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
488223003425	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
488223003426	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
488223003427	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
488223003428	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
488223003429	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
488223003430	tetramer (dimer of dimers) interface [polypeptide binding]; other site
488223003431	NAD binding site [chemical binding]; other site
488223003432	dimer interface [polypeptide binding]; other site
488223003433	substrate binding site [chemical binding]; other site
488223003434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
488223003435	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
488223003436	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
488223003437	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
488223003438	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
488223003439	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
488223003440	putative active site [active]
488223003441	heme pocket [chemical binding]; other site
488223003442	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
488223003443	dimer interface [polypeptide binding]; other site
488223003444	phosphorylation site [posttranslational modification]
488223003445	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223003446	ATP binding site [chemical binding]; other site
488223003447	Mg2+ binding site [ion binding]; other site
488223003448	G-X-G motif; other site
488223003449	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
488223003450	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488223003451	active site
488223003452	phosphorylation site [posttranslational modification]
488223003453	intermolecular recognition site; other site
488223003454	dimerization interface [polypeptide binding]; other site
488223003455	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488223003456	DNA binding site [nucleotide binding]
488223003457	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
488223003458	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
488223003459	minor groove reading motif; other site
488223003460	helix-hairpin-helix signature motif; other site
488223003461	substrate binding pocket [chemical binding]; other site
488223003462	active site
488223003463	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
488223003464	DNA binding and oxoG recognition site [nucleotide binding]
488223003465	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
488223003466	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
488223003467	Potassium binding sites [ion binding]; other site
488223003468	Cesium cation binding sites [ion binding]; other site
488223003469	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
488223003470	phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113
488223003471	Flavoprotein; Region: Flavoprotein; pfam02441
488223003472	Predicted membrane protein [Function unknown]; Region: COG4684
488223003473	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
488223003474	HTH domain; Region: HTH_11; pfam08279
488223003475	3H domain; Region: 3H; pfam02829
488223003476	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
488223003477	putative active site [active]
488223003478	nucleotide binding site [chemical binding]; other site
488223003479	nudix motif; other site
488223003480	putative metal binding site [ion binding]; other site
488223003481	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
488223003482	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488223003483	Coenzyme A binding pocket [chemical binding]; other site
488223003484	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
488223003485	excinuclease ABC subunit B; Provisional; Region: PRK05298
488223003486	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488223003487	ATP binding site [chemical binding]; other site
488223003488	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488223003489	nucleotide binding region [chemical binding]; other site
488223003490	ATP-binding site [chemical binding]; other site
488223003491	Ultra-violet resistance protein B; Region: UvrB; pfam12344
488223003492	UvrB/uvrC motif; Region: UVR; pfam02151
488223003493	CAAX protease self-immunity; Region: Abi; pfam02517
488223003494	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488223003495	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
488223003496	substrate binding pocket [chemical binding]; other site
488223003497	membrane-bound complex binding site; other site
488223003498	hinge residues; other site
488223003499	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488223003500	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
488223003501	substrate binding pocket [chemical binding]; other site
488223003502	membrane-bound complex binding site; other site
488223003503	hinge residues; other site
488223003504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223003505	dimer interface [polypeptide binding]; other site
488223003506	conserved gate region; other site
488223003507	putative PBP binding loops; other site
488223003508	ABC-ATPase subunit interface; other site
488223003509	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
488223003510	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
488223003511	Walker A/P-loop; other site
488223003512	ATP binding site [chemical binding]; other site
488223003513	Q-loop/lid; other site
488223003514	ABC transporter signature motif; other site
488223003515	Walker B; other site
488223003516	D-loop; other site
488223003517	H-loop/switch region; other site
488223003518	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
488223003519	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
488223003520	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
488223003521	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
488223003522	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
488223003523	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
488223003524	P loop; other site
488223003525	GTP binding site [chemical binding]; other site
488223003526	sugar phosphate phosphatase; Provisional; Region: PRK10513
488223003527	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223003528	motif II; other site
488223003529	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
488223003530	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
488223003531	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223003532	active site
488223003533	motif I; other site
488223003534	motif II; other site
488223003535	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
488223003536	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
488223003537	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
488223003538	Walker A/P-loop; other site
488223003539	ATP binding site [chemical binding]; other site
488223003540	Q-loop/lid; other site
488223003541	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
488223003542	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
488223003543	ABC transporter signature motif; other site
488223003544	Walker B; other site
488223003545	D-loop; other site
488223003546	H-loop/switch region; other site
488223003547	ribonuclease III; Reviewed; Region: rnc; PRK00102
488223003548	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
488223003549	dimerization interface [polypeptide binding]; other site
488223003550	active site
488223003551	metal binding site [ion binding]; metal-binding site
488223003552	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
488223003553	dsRNA binding site [nucleotide binding]; other site
488223003554	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
488223003555	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
488223003556	active site
488223003557	McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268
488223003558	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
488223003559	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223003560	Walker A motif; other site
488223003561	ATP binding site [chemical binding]; other site
488223003562	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
488223003563	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
488223003564	substrate binding site [chemical binding]; other site
488223003565	Predicted membrane protein [Function unknown]; Region: COG3326
488223003566	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
488223003567	tartrate dehydrogenase; Region: TTC; TIGR02089
488223003568	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
488223003569	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
488223003570	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
488223003571	DNA topoisomerase I; Validated; Region: PRK05582
488223003572	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
488223003573	active site
488223003574	interdomain interaction site; other site
488223003575	putative metal-binding site [ion binding]; other site
488223003576	nucleotide binding site [chemical binding]; other site
488223003577	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
488223003578	domain I; other site
488223003579	DNA binding groove [nucleotide binding]
488223003580	phosphate binding site [ion binding]; other site
488223003581	domain II; other site
488223003582	domain III; other site
488223003583	nucleotide binding site [chemical binding]; other site
488223003584	catalytic site [active]
488223003585	domain IV; other site
488223003586	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
488223003587	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
488223003588	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
488223003589	Predicted membrane protein [Function unknown]; Region: COG1808
488223003590	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
488223003591	DNA protecting protein DprA; Region: dprA; TIGR00732
488223003592	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
488223003593	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
488223003594	active site
488223003595	metal-binding site
488223003596	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
488223003597	Phosphotransferase enzyme family; Region: APH; pfam01636
488223003598	active site
488223003599	substrate binding site [chemical binding]; other site
488223003600	ATP binding site [chemical binding]; other site
488223003601	dimer interface [polypeptide binding]; other site
488223003602	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
488223003603	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
488223003604	putative NAD(P) binding site [chemical binding]; other site
488223003605	putative catalytic Zn binding site [ion binding]; other site
488223003606	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
488223003607	substrate binding site; other site
488223003608	dimer interface; other site
488223003609	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
488223003610	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
488223003611	LicD family; Region: LicD; cl01378
488223003612	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
488223003613	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
488223003614	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
488223003615	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
488223003616	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
488223003617	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
488223003618	ATP-grasp domain; Region: ATP-grasp_4; cl17255
488223003619	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
488223003620	IMP binding site; other site
488223003621	dimer interface [polypeptide binding]; other site
488223003622	interdomain contacts; other site
488223003623	partial ornithine binding site; other site
488223003624	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
488223003625	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
488223003626	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
488223003627	catalytic site [active]
488223003628	subunit interface [polypeptide binding]; other site
488223003629	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
488223003630	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
488223003631	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
488223003632	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
488223003633	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488223003634	active site
488223003635	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
488223003636	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
488223003637	minor groove reading motif; other site
488223003638	helix-hairpin-helix signature motif; other site
488223003639	substrate binding pocket [chemical binding]; other site
488223003640	active site
488223003641	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
488223003642	potential frameshift: common BLAST hit: gi|169832948|ref|YP_001694706.1| BlpT protein, fusion
488223003643	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
488223003644	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488223003645	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488223003646	heat shock protein HtpX; Provisional; Region: PRK04897
488223003647	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
488223003648	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
488223003649	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223003650	S-adenosylmethionine binding site [chemical binding]; other site
488223003651	uracil transporter; Provisional; Region: PRK10720
488223003652	signal recognition particle protein; Provisional; Region: PRK10867
488223003653	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
488223003654	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
488223003655	P loop; other site
488223003656	GTP binding site [chemical binding]; other site
488223003657	Signal peptide binding domain; Region: SRP_SPB; pfam02978
488223003658	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
488223003659	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
488223003660	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
488223003661	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
488223003662	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
488223003663	Zn2+ binding site [ion binding]; other site
488223003664	Mg2+ binding site [ion binding]; other site
488223003665	sugar phosphate phosphatase; Provisional; Region: PRK10513
488223003666	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223003667	active site
488223003668	motif I; other site
488223003669	motif II; other site
488223003670	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223003671	SAP domain; Region: SAP; pfam02037
488223003672	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
488223003673	camphor resistance protein CrcB; Provisional; Region: PRK14229
488223003674	camphor resistance protein CrcB; Provisional; Region: PRK14221
488223003675	hypothetical protein; Provisional; Region: PRK07248
488223003676	flavodoxin; Validated; Region: PRK07308
488223003677	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
488223003678	DHH family; Region: DHH; pfam01368
488223003679	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
488223003680	Winged helix-turn helix; Region: HTH_29; pfam13551
488223003681	Homeodomain-like domain; Region: HTH_32; pfam13565
488223003682	glutamate dehydrogenase; Provisional; Region: PRK09414
488223003683	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
488223003684	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
488223003685	NAD(P) binding site [chemical binding]; other site
488223003686	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223003687	Walker A/P-loop; other site
488223003688	ATP binding site [chemical binding]; other site
488223003689	ABC transporter; Region: ABC_tran; pfam00005
488223003690	Q-loop/lid; other site
488223003691	ABC transporter signature motif; other site
488223003692	Walker B; other site
488223003693	D-loop; other site
488223003694	H-loop/switch region; other site
488223003695	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
488223003696	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
488223003697	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
488223003698	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
488223003699	Class I aldolases; Region: Aldolase_Class_I; cl17187
488223003700	catalytic residue [active]
488223003701	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
488223003702	active site
488223003703	catalytic motif [active]
488223003704	Zn binding site [ion binding]; other site
488223003705	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
488223003706	tetramer interfaces [polypeptide binding]; other site
488223003707	binuclear metal-binding site [ion binding]; other site
488223003708	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
488223003709	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
488223003710	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
488223003711	Walker A/P-loop; other site
488223003712	ATP binding site [chemical binding]; other site
488223003713	Q-loop/lid; other site
488223003714	ABC transporter signature motif; other site
488223003715	Walker B; other site
488223003716	D-loop; other site
488223003717	H-loop/switch region; other site
488223003718	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
488223003719	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
488223003720	Walker A/P-loop; other site
488223003721	ATP binding site [chemical binding]; other site
488223003722	Q-loop/lid; other site
488223003723	ABC transporter signature motif; other site
488223003724	Walker B; other site
488223003725	D-loop; other site
488223003726	H-loop/switch region; other site
488223003727	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
488223003728	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
488223003729	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223003730	dimer interface [polypeptide binding]; other site
488223003731	conserved gate region; other site
488223003732	putative PBP binding loops; other site
488223003733	ABC-ATPase subunit interface; other site
488223003734	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
488223003735	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223003736	dimer interface [polypeptide binding]; other site
488223003737	conserved gate region; other site
488223003738	putative PBP binding loops; other site
488223003739	ABC-ATPase subunit interface; other site
488223003740	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
488223003741	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
488223003742	cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548
488223003743	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
488223003744	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
488223003745	putative active site cavity [active]
488223003746	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
488223003747	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
488223003748	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
488223003749	CAAX protease self-immunity; Region: Abi; pfam02517
488223003750	Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393
488223003751	ArsC family; Region: ArsC; pfam03960
488223003752	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
488223003753	core dimer interface [polypeptide binding]; other site
488223003754	L10 interface [polypeptide binding]; other site
488223003755	L11 interface [polypeptide binding]; other site
488223003756	putative EF-Tu interaction site [polypeptide binding]; other site
488223003757	putative EF-G interaction site [polypeptide binding]; other site
488223003758	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
488223003759	23S rRNA interface [nucleotide binding]; other site
488223003760	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
488223003761	chlorohydrolase; Validated; Region: PRK06687
488223003762	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
488223003763	active site
488223003764	putative substrate binding pocket [chemical binding]; other site
488223003765	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
488223003766	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488223003767	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
488223003768	Walker A/P-loop; other site
488223003769	ATP binding site [chemical binding]; other site
488223003770	Q-loop/lid; other site
488223003771	ABC transporter signature motif; other site
488223003772	Walker B; other site
488223003773	D-loop; other site
488223003774	H-loop/switch region; other site
488223003775	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
488223003776	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488223003777	APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination; Region: APC10-like; cl02148
488223003778	putative ligand binding site [chemical binding]; other site
488223003779	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223003780	Walker A/P-loop; other site
488223003781	ATP binding site [chemical binding]; other site
488223003782	Q-loop/lid; other site
488223003783	ABC transporter signature motif; other site
488223003784	Walker B; other site
488223003785	D-loop; other site
488223003786	H-loop/switch region; other site
488223003787	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
488223003788	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
488223003789	SelR domain; Region: SelR; pfam01641
488223003790	homoserine kinase; Provisional; Region: PRK01212
488223003791	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
488223003792	homoserine dehydrogenase; Provisional; Region: PRK06349
488223003793	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
488223003794	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
488223003795	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
488223003796	adaptor protein; Provisional; Region: PRK02315
488223003797	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
488223003798	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
488223003799	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
488223003800	active site
488223003801	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
488223003802	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
488223003803	putative ADP-binding pocket [chemical binding]; other site
488223003804	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
488223003805	Transcriptional regulator [Transcription]; Region: LytR; COG1316
488223003806	prephenate dehydratase; Provisional; Region: PRK11898
488223003807	Prephenate dehydratase; Region: PDT; pfam00800
488223003808	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
488223003809	putative L-Phe binding site [chemical binding]; other site
488223003810	shikimate kinase; Reviewed; Region: aroK; PRK00131
488223003811	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
488223003812	ADP binding site [chemical binding]; other site
488223003813	magnesium binding site [ion binding]; other site
488223003814	putative shikimate binding site; other site
488223003815	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
488223003816	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
488223003817	hinge; other site
488223003818	active site
488223003819	hypothetical protein; Provisional; Region: PRK13676
488223003820	prephenate dehydrogenase; Validated; Region: PRK06545
488223003821	prephenate dehydrogenase; Validated; Region: PRK08507
488223003822	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
488223003823	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
488223003824	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
488223003825	Tetramer interface [polypeptide binding]; other site
488223003826	active site
488223003827	FMN-binding site [chemical binding]; other site
488223003828	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
488223003829	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
488223003830	active site
488223003831	dimer interface [polypeptide binding]; other site
488223003832	metal binding site [ion binding]; metal-binding site
488223003833	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
488223003834	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
488223003835	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
488223003836	shikimate binding site; other site
488223003837	NAD(P) binding site [chemical binding]; other site
488223003838	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
488223003839	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
488223003840	active site
488223003841	catalytic residue [active]
488223003842	dimer interface [polypeptide binding]; other site
488223003843	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
488223003844	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
488223003845	putative RNA binding site [nucleotide binding]; other site
488223003846	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223003847	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
488223003848	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
488223003849	Walker A/P-loop; other site
488223003850	ATP binding site [chemical binding]; other site
488223003851	Q-loop/lid; other site
488223003852	ABC transporter signature motif; other site
488223003853	Walker B; other site
488223003854	D-loop; other site
488223003855	H-loop/switch region; other site
488223003856	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
488223003857	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
488223003858	active site
488223003859	Na/Ca binding site [ion binding]; other site
488223003860	catalytic site [active]
488223003861	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
488223003862	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
488223003863	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
488223003864	motif 1; other site
488223003865	active site
488223003866	motif 2; other site
488223003867	motif 3; other site
488223003868	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
488223003869	DHHA1 domain; Region: DHHA1; pfam02272
488223003870	Uncharacterized conserved protein [Function unknown]; Region: COG4894
488223003871	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
488223003872	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
488223003873	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
488223003874	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223003875	dimer interface [polypeptide binding]; other site
488223003876	conserved gate region; other site
488223003877	putative PBP binding loops; other site
488223003878	ABC-ATPase subunit interface; other site
488223003879	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223003880	dimer interface [polypeptide binding]; other site
488223003881	conserved gate region; other site
488223003882	putative PBP binding loops; other site
488223003883	ABC-ATPase subunit interface; other site
488223003884	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
488223003885	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
488223003886	Walker A/P-loop; other site
488223003887	ATP binding site [chemical binding]; other site
488223003888	Q-loop/lid; other site
488223003889	ABC transporter signature motif; other site
488223003890	Walker B; other site
488223003891	D-loop; other site
488223003892	H-loop/switch region; other site
488223003893	TOBE domain; Region: TOBE_2; pfam08402
488223003894	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
488223003895	FAD binding domain; Region: FAD_binding_4; pfam01565
488223003896	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
488223003897	Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810
488223003898	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
488223003899	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
488223003900	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
488223003901	DNA-binding site [nucleotide binding]; DNA binding site
488223003902	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488223003903	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488223003904	homodimer interface [polypeptide binding]; other site
488223003905	catalytic residue [active]
488223003906	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488223003907	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
488223003908	substrate binding pocket [chemical binding]; other site
488223003909	membrane-bound complex binding site; other site
488223003910	hinge residues; other site
488223003911	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
488223003912	PhoU domain; Region: PhoU; pfam01895
488223003913	PhoU domain; Region: PhoU; pfam01895
488223003914	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
488223003915	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
488223003916	Walker A/P-loop; other site
488223003917	ATP binding site [chemical binding]; other site
488223003918	Q-loop/lid; other site
488223003919	ABC transporter signature motif; other site
488223003920	Walker B; other site
488223003921	D-loop; other site
488223003922	H-loop/switch region; other site
488223003923	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
488223003924	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
488223003925	Walker A/P-loop; other site
488223003926	ATP binding site [chemical binding]; other site
488223003927	Q-loop/lid; other site
488223003928	ABC transporter signature motif; other site
488223003929	Walker B; other site
488223003930	D-loop; other site
488223003931	H-loop/switch region; other site
488223003932	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
488223003933	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223003934	dimer interface [polypeptide binding]; other site
488223003935	conserved gate region; other site
488223003936	putative PBP binding loops; other site
488223003937	ABC-ATPase subunit interface; other site
488223003938	sulfate transport protein; Provisional; Region: cysT; CHL00187
488223003939	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223003940	dimer interface [polypeptide binding]; other site
488223003941	conserved gate region; other site
488223003942	putative PBP binding loops; other site
488223003943	ABC-ATPase subunit interface; other site
488223003944	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
488223003945	phosphate binding protein; Region: ptsS_2; TIGR02136
488223003946	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
488223003947	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223003948	S-adenosylmethionine binding site [chemical binding]; other site
488223003949	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
488223003950	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
488223003951	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
488223003952	active site
488223003953	hypothetical protein; Provisional; Region: PRK04387
488223003954	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
488223003955	ArsC family; Region: ArsC; pfam03960
488223003956	putative catalytic residues [active]
488223003957	thiol/disulfide switch; other site
488223003958	Predicted membrane protein [Function unknown]; Region: COG4478
488223003959	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
488223003960	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223003961	active site
488223003962	motif I; other site
488223003963	motif II; other site
488223003964	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223003965	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
488223003966	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
488223003967	active site
488223003968	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
488223003969	active site
488223003970	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
488223003971	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
488223003972	FeS/SAM binding site; other site
488223003973	HemN C-terminal domain; Region: HemN_C; pfam06969
488223003974	YtxH-like protein; Region: YtxH; pfam12732
488223003975	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
488223003976	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
488223003977	HPr kinase/phosphorylase; Provisional; Region: PRK05428
488223003978	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
488223003979	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
488223003980	Hpr binding site; other site
488223003981	active site
488223003982	homohexamer subunit interaction site [polypeptide binding]; other site
488223003983	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
488223003984	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
488223003985	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
488223003986	active site
488223003987	trimer interface [polypeptide binding]; other site
488223003988	allosteric site; other site
488223003989	active site lid [active]
488223003990	hexamer (dimer of trimers) interface [polypeptide binding]; other site
488223003991	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
488223003992	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
488223003993	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
488223003994	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223003995	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
488223003996	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
488223003997	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
488223003998	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
488223003999	homodimer interface [polypeptide binding]; other site
488223004000	NAD binding pocket [chemical binding]; other site
488223004001	ATP binding pocket [chemical binding]; other site
488223004002	Mg binding site [ion binding]; other site
488223004003	active-site loop [active]
488223004004	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
488223004005	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
488223004006	active site
488223004007	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223004008	non-specific DNA binding site [nucleotide binding]; other site
488223004009	salt bridge; other site
488223004010	sequence-specific DNA binding site [nucleotide binding]; other site
488223004011	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
488223004012	CHY zinc finger; Region: zf-CHY; pfam05495
488223004013	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
488223004014	Peptidase family U32; Region: Peptidase_U32; pfam01136
488223004015	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
488223004016	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
488223004017	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223004018	S-adenosylmethionine binding site [chemical binding]; other site
488223004019	Helix-turn-helix domain; Region: HTH_18; pfam12833
488223004020	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
488223004021	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
488223004022	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488223004023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223004024	Walker A/P-loop; other site
488223004025	ATP binding site [chemical binding]; other site
488223004026	Q-loop/lid; other site
488223004027	ABC transporter signature motif; other site
488223004028	Walker B; other site
488223004029	D-loop; other site
488223004030	H-loop/switch region; other site
488223004031	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
488223004032	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223004033	Walker A/P-loop; other site
488223004034	ATP binding site [chemical binding]; other site
488223004035	Q-loop/lid; other site
488223004036	ABC transporter signature motif; other site
488223004037	Walker B; other site
488223004038	D-loop; other site
488223004039	H-loop/switch region; other site
488223004040	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
488223004041	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
488223004042	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
488223004043	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
488223004044	Walker A/P-loop; other site
488223004045	ATP binding site [chemical binding]; other site
488223004046	Q-loop/lid; other site
488223004047	ABC transporter signature motif; other site
488223004048	Walker B; other site
488223004049	D-loop; other site
488223004050	H-loop/switch region; other site
488223004051	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223004052	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
488223004053	Walker A/P-loop; other site
488223004054	ATP binding site [chemical binding]; other site
488223004055	Q-loop/lid; other site
488223004056	ABC transporter signature motif; other site
488223004057	Walker B; other site
488223004058	D-loop; other site
488223004059	H-loop/switch region; other site
488223004060	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
488223004061	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
488223004062	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
488223004063	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
488223004064	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
488223004065	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
488223004066	GMP synthase; Reviewed; Region: guaA; PRK00074
488223004067	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
488223004068	AMP/PPi binding site [chemical binding]; other site
488223004069	candidate oxyanion hole; other site
488223004070	catalytic triad [active]
488223004071	potential glutamine specificity residues [chemical binding]; other site
488223004072	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
488223004073	ATP Binding subdomain [chemical binding]; other site
488223004074	Dimerization subdomain; other site
488223004075	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
488223004076	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
488223004077	DNA-binding site [nucleotide binding]; DNA binding site
488223004078	UTRA domain; Region: UTRA; pfam07702
488223004079	EamA-like transporter family; Region: EamA; pfam00892
488223004080	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
488223004081	Beta-lactamase; Region: Beta-lactamase; pfam00144
488223004082	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
488223004083	active site
488223004084	catalytic triad [active]
488223004085	oxyanion hole [active]
488223004086	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
488223004087	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223004088	active site
488223004089	motif I; other site
488223004090	motif II; other site
488223004091	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223004092	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
488223004093	active site
488223004094	catalytic residues [active]
488223004095	metal binding site [ion binding]; metal-binding site
488223004096	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
488223004097	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
488223004098	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
488223004099	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
488223004100	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
488223004101	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
488223004102	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
488223004103	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
488223004104	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
488223004105	Walker A/P-loop; other site
488223004106	ATP binding site [chemical binding]; other site
488223004107	Q-loop/lid; other site
488223004108	ABC transporter signature motif; other site
488223004109	Walker B; other site
488223004110	D-loop; other site
488223004111	H-loop/switch region; other site
488223004112	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
488223004113	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223004114	ABC-ATPase subunit interface; other site
488223004115	putative PBP binding loops; other site
488223004116	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
488223004117	putative ArsC-like catalytic residues; other site
488223004118	putative TRX-like catalytic residues [active]
488223004119	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
488223004120	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
488223004121	DNA binding site [nucleotide binding]
488223004122	active site
488223004123	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
488223004124	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
488223004125	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
488223004126	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
488223004127	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
488223004128	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
488223004129	predicted active site [active]
488223004130	catalytic triad [active]
488223004131	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
488223004132	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
488223004133	active site
488223004134	multimer interface [polypeptide binding]; other site
488223004135	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
488223004136	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
488223004137	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
488223004138	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
488223004139	ApbE family; Region: ApbE; pfam02424
488223004140	Predicted flavoprotein [General function prediction only]; Region: COG0431
488223004141	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
488223004142	Predicted flavoprotein [General function prediction only]; Region: COG0431
488223004143	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
488223004144	PAS domain; Region: PAS_10; pfam13596
488223004145	hypothetical protein; Provisional; Region: PRK02539
488223004146	Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751
488223004147	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
488223004148	DALR anticodon binding domain; Region: DALR_1; pfam05746
488223004149	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
488223004150	dimer interface [polypeptide binding]; other site
488223004151	motif 1; other site
488223004152	active site
488223004153	motif 2; other site
488223004154	motif 3; other site
488223004155	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
488223004156	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
488223004157	active site
488223004158	catalytic tetrad [active]
488223004159	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
488223004160	Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947
488223004161	NodB motif; other site
488223004162	active site
488223004163	catalytic site [active]
488223004164	Zn binding site [ion binding]; other site
488223004165	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
488223004166	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
488223004167	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
488223004168	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
488223004169	DEAD-like helicases superfamily; Region: DEXDc; smart00487
488223004170	ATP binding site [chemical binding]; other site
488223004171	putative Mg++ binding site [ion binding]; other site
488223004172	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488223004173	nucleotide binding region [chemical binding]; other site
488223004174	ATP-binding site [chemical binding]; other site
488223004175	DDE superfamily endonuclease; Region: DDE_3; pfam13358
488223004176	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
488223004177	Winged helix-turn helix; Region: HTH_33; pfam13592
488223004178	elongation factor Tu; Reviewed; Region: PRK00049
488223004179	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
488223004180	G1 box; other site
488223004181	GEF interaction site [polypeptide binding]; other site
488223004182	GTP/Mg2+ binding site [chemical binding]; other site
488223004183	Switch I region; other site
488223004184	G2 box; other site
488223004185	G3 box; other site
488223004186	Switch II region; other site
488223004187	G4 box; other site
488223004188	G5 box; other site
488223004189	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
488223004190	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
488223004191	Antibiotic Binding Site [chemical binding]; other site
488223004192	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
488223004193	amphipathic channel; other site
488223004194	Asn-Pro-Ala signature motifs; other site
488223004195	MucBP domain; Region: MucBP; pfam06458
488223004196	DDE superfamily endonuclease; Region: DDE_3; pfam13358
488223004197	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
488223004198	Transposase; Region: HTH_Tnp_IS630; pfam01710
488223004199	Helix-turn-helix domain; Region: HTH_28; pfam13518
488223004200	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
488223004201	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
488223004202	active site
488223004203	substrate binding site [chemical binding]; other site
488223004204	metal binding site [ion binding]; metal-binding site
488223004205	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
488223004206	catalytic residues [active]
488223004207	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
488223004208	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
488223004209	substrate binding pocket [chemical binding]; other site
488223004210	membrane-bound complex binding site; other site
488223004211	hinge residues; other site
488223004212	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
488223004213	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223004214	Walker A/P-loop; other site
488223004215	ATP binding site [chemical binding]; other site
488223004216	Q-loop/lid; other site
488223004217	ABC transporter signature motif; other site
488223004218	Walker B; other site
488223004219	D-loop; other site
488223004220	H-loop/switch region; other site
488223004221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223004222	dimer interface [polypeptide binding]; other site
488223004223	conserved gate region; other site
488223004224	putative PBP binding loops; other site
488223004225	ABC-ATPase subunit interface; other site
488223004226	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
488223004227	TPR motif; other site
488223004228	binding surface
488223004229	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
488223004230	binding surface
488223004231	TPR motif; other site
488223004232	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
488223004233	Domain of unknown function DUF20; Region: UPF0118; pfam01594
488223004234	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
488223004235	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
488223004236	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
488223004237	gamma subunit interface [polypeptide binding]; other site
488223004238	epsilon subunit interface [polypeptide binding]; other site
488223004239	LBP interface [polypeptide binding]; other site
488223004240	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
488223004241	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
488223004242	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
488223004243	alpha subunit interaction interface [polypeptide binding]; other site
488223004244	Walker A motif; other site
488223004245	ATP binding site [chemical binding]; other site
488223004246	Walker B motif; other site
488223004247	inhibitor binding site; inhibition site
488223004248	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
488223004249	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
488223004250	core domain interface [polypeptide binding]; other site
488223004251	delta subunit interface [polypeptide binding]; other site
488223004252	epsilon subunit interface [polypeptide binding]; other site
488223004253	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
488223004254	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
488223004255	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
488223004256	beta subunit interaction interface [polypeptide binding]; other site
488223004257	Walker A motif; other site
488223004258	ATP binding site [chemical binding]; other site
488223004259	Walker B motif; other site
488223004260	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
488223004261	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
488223004262	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
488223004263	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
488223004264	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
488223004265	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
488223004266	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
488223004267	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
488223004268	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
488223004269	Helix-turn-helix domain; Region: HTH_38; pfam13936
488223004270	Integrase core domain; Region: rve; pfam00665
488223004271	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
488223004272	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
488223004273	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
488223004274	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
488223004275	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
488223004276	dimerization interface [polypeptide binding]; other site
488223004277	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
488223004278	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488223004279	Coenzyme A binding pocket [chemical binding]; other site
488223004280	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488223004281	Coenzyme A binding pocket [chemical binding]; other site
488223004282	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
488223004283	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
488223004284	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
488223004285	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
488223004286	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
488223004287	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
488223004288	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488223004289	ATP binding site [chemical binding]; other site
488223004290	putative Mg++ binding site [ion binding]; other site
488223004291	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488223004292	nucleotide binding region [chemical binding]; other site
488223004293	ATP-binding site [chemical binding]; other site
488223004294	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
488223004295	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488223004296	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488223004297	homodimer interface [polypeptide binding]; other site
488223004298	catalytic residue [active]
488223004299	cystathionine gamma-synthase; Reviewed; Region: PRK07269
488223004300	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
488223004301	homodimer interface [polypeptide binding]; other site
488223004302	substrate-cofactor binding pocket; other site
488223004303	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488223004304	catalytic residue [active]
488223004305	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223004306	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
488223004307	Walker A/P-loop; other site
488223004308	ATP binding site [chemical binding]; other site
488223004309	Q-loop/lid; other site
488223004310	ABC transporter signature motif; other site
488223004311	Walker B; other site
488223004312	D-loop; other site
488223004313	H-loop/switch region; other site
488223004314	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
488223004315	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
488223004316	peptide binding site [polypeptide binding]; other site
488223004317	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
488223004318	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
488223004319	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
488223004320	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
488223004321	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
488223004322	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
488223004323	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
488223004324	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
488223004325	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
488223004326	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
488223004327	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
488223004328	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
488223004329	DHH family; Region: DHH; pfam01368
488223004330	DHHA2 domain; Region: DHHA2; pfam02833
488223004331	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
488223004332	GIY-YIG motif/motif A; other site
488223004333	putative active site [active]
488223004334	putative metal binding site [ion binding]; other site
488223004335	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
488223004336	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223004337	S-adenosylmethionine binding site [chemical binding]; other site
488223004338	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
488223004339	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
488223004340	RNA binding site [nucleotide binding]; other site
488223004341	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223004342	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
488223004343	active site
488223004344	motif I; other site
488223004345	motif II; other site
488223004346	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223004347	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
488223004348	active site
488223004349	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
488223004350	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
488223004351	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
488223004352	dimer interface [polypeptide binding]; other site
488223004353	ssDNA binding site [nucleotide binding]; other site
488223004354	tetramer (dimer of dimers) interface [polypeptide binding]; other site
488223004355	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
488223004356	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
488223004357	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
488223004358	putative dimer interface [polypeptide binding]; other site
488223004359	putative anticodon binding site; other site
488223004360	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
488223004361	homodimer interface [polypeptide binding]; other site
488223004362	motif 1; other site
488223004363	motif 2; other site
488223004364	active site
488223004365	motif 3; other site
488223004366	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
488223004367	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
488223004368	aspartate aminotransferase; Provisional; Region: PRK05764
488223004369	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488223004370	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488223004371	homodimer interface [polypeptide binding]; other site
488223004372	catalytic residue [active]
488223004373	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
488223004374	Predicted flavoprotein [General function prediction only]; Region: COG0431
488223004375	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
488223004376	hypothetical protein; Validated; Region: PRK02101
488223004377	Protein of unknown function (DUF3953); Region: DUF3953; pfam13129
488223004378	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
488223004379	active site
488223004380	catalytic residues [active]
488223004381	metal binding site [ion binding]; metal-binding site
488223004382	putative S-transferase; Provisional; Region: PRK11752
488223004383	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
488223004384	C-terminal domain interface [polypeptide binding]; other site
488223004385	GSH binding site (G-site) [chemical binding]; other site
488223004386	dimer interface [polypeptide binding]; other site
488223004387	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
488223004388	N-terminal domain interface [polypeptide binding]; other site
488223004389	dimer interface [polypeptide binding]; other site
488223004390	substrate binding pocket (H-site) [chemical binding]; other site
488223004391	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
488223004392	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
488223004393	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
488223004394	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
488223004395	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
488223004396	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
488223004397	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
488223004398	Cation efflux family; Region: Cation_efflux; pfam01545
488223004399	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
488223004400	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
488223004401	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223004402	Walker A/P-loop; other site
488223004403	ATP binding site [chemical binding]; other site
488223004404	Q-loop/lid; other site
488223004405	ABC transporter signature motif; other site
488223004406	Walker B; other site
488223004407	D-loop; other site
488223004408	H-loop/switch region; other site
488223004409	ABC transporter; Region: ABC_tran_2; pfam12848
488223004410	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488223004411	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
488223004412	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
488223004413	active site
488223004414	NTP binding site [chemical binding]; other site
488223004415	metal binding triad [ion binding]; metal-binding site
488223004416	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
488223004417	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
488223004418	dihydrodipicolinate reductase; Provisional; Region: PRK00048
488223004419	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
488223004420	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
488223004421	EDD domain protein, DegV family; Region: DegV; TIGR00762
488223004422	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
488223004423	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835
488223004424	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
488223004425	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
488223004426	active site
488223004427	substrate binding site [chemical binding]; other site
488223004428	metal binding site [ion binding]; metal-binding site
488223004429	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
488223004430	YbbR-like protein; Region: YbbR; pfam07949
488223004431	Uncharacterized conserved protein [Function unknown]; Region: COG1624
488223004432	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
488223004433	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
488223004434	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
488223004435	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
488223004436	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
488223004437	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
488223004438	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
488223004439	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
488223004440	dimer interface [polypeptide binding]; other site
488223004441	phosphate binding site [ion binding]; other site
488223004442	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
488223004443	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
488223004444	homotrimer interaction site [polypeptide binding]; other site
488223004445	putative active site [active]
488223004446	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
488223004447	G1 box; other site
488223004448	GTP/Mg2+ binding site [chemical binding]; other site
488223004449	Switch I region; other site
488223004450	G2 box; other site
488223004451	G3 box; other site
488223004452	Switch II region; other site
488223004453	G4 box; other site
488223004454	G5 box; other site
488223004455	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
488223004456	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
488223004457	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223004458	Walker A motif; other site
488223004459	ATP binding site [chemical binding]; other site
488223004460	Walker B motif; other site
488223004461	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
488223004462	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
488223004463	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
488223004464	folate binding site [chemical binding]; other site
488223004465	NADP+ binding site [chemical binding]; other site
488223004466	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
488223004467	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
488223004468	dimerization interface [polypeptide binding]; other site
488223004469	DPS ferroxidase diiron center [ion binding]; other site
488223004470	ion pore; other site
488223004471	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
488223004472	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
488223004473	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
488223004474	active site
488223004475	triosephosphate isomerase; Provisional; Region: PRK14567
488223004476	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
488223004477	substrate binding site [chemical binding]; other site
488223004478	dimer interface [polypeptide binding]; other site
488223004479	catalytic triad [active]
488223004480	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
488223004481	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
488223004482	Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897
488223004483	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
488223004484	proposed active site lysine [active]
488223004485	conserved cys residue [active]
488223004486	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488223004487	active site
488223004488	Methyltransferase domain; Region: Methyltransf_31; pfam13847
488223004489	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223004490	S-adenosylmethionine binding site [chemical binding]; other site
488223004491	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
488223004492	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
488223004493	Walker A/P-loop; other site
488223004494	ATP binding site [chemical binding]; other site
488223004495	Q-loop/lid; other site
488223004496	ABC transporter signature motif; other site
488223004497	Walker B; other site
488223004498	D-loop; other site
488223004499	H-loop/switch region; other site
488223004500	TOBE domain; Region: TOBE_2; pfam08402
488223004501	Isochorismatase family; Region: Isochorismatase; pfam00857
488223004502	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
488223004503	catalytic triad [active]
488223004504	conserved cis-peptide bond; other site
488223004505	Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465
488223004506	CodY GAF-like domain; Region: CodY; pfam06018
488223004507	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
488223004508	putative DNA binding site [nucleotide binding]; other site
488223004509	putative Zn2+ binding site [ion binding]; other site
488223004510	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
488223004511	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
488223004512	ATP binding site [chemical binding]; other site
488223004513	Mg++ binding site [ion binding]; other site
488223004514	motif III; other site
488223004515	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488223004516	nucleotide binding region [chemical binding]; other site
488223004517	ATP-binding site [chemical binding]; other site
488223004518	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
488223004519	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488223004520	putative substrate translocation pore; other site
488223004521	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
488223004522	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
488223004523	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
488223004524	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
488223004525	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
488223004526	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
488223004527	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
488223004528	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
488223004529	catalytic triad [active]
488223004530	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
488223004531	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
488223004532	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
488223004533	active site
488223004534	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
488223004535	Integrase core domain; Region: rve; pfam00665
488223004536	Integrase core domain; Region: rve_2; pfam13333
488223004537	Predicted membrane protein [Function unknown]; Region: COG4720
488223004538	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
488223004539	dimer interface [polypeptide binding]; other site
488223004540	substrate binding site [chemical binding]; other site
488223004541	ATP binding site [chemical binding]; other site
488223004542	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
488223004543	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
488223004544	dimerization interface 3.5A [polypeptide binding]; other site
488223004545	active site
488223004546	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488223004547	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
488223004548	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
488223004549	PhnA protein; Region: PhnA; pfam03831
488223004550	cytidylate kinase; Provisional; Region: cmk; PRK00023
488223004551	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
488223004552	CMP-binding site; other site
488223004553	The sites determining sugar specificity; other site
488223004554	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
488223004555	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
488223004556	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
488223004557	Ligand binding site; other site
488223004558	Putative Catalytic site; other site
488223004559	DXD motif; other site
488223004560	UDP-glucose 4-epimerase; Region: PLN02240
488223004561	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
488223004562	NAD binding site [chemical binding]; other site
488223004563	homodimer interface [polypeptide binding]; other site
488223004564	active site
488223004565	substrate binding site [chemical binding]; other site
488223004566	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
488223004567	Uncharacterized conserved protein [Function unknown]; Region: COG0327
488223004568	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
488223004569	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
488223004570	Family of unknown function (DUF633); Region: DUF633; pfam04816
488223004571	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
488223004572	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
488223004573	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
488223004574	Homeodomain-like domain; Region: HTH_23; cl17451
488223004575	Transposase; Region: HTH_Tnp_1; cl17663
488223004576	HTH-like domain; Region: HTH_21; pfam13276
488223004577	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
488223004578	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
488223004579	TPP-binding site [chemical binding]; other site
488223004580	dimer interface [polypeptide binding]; other site
488223004581	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
488223004582	PYR/PP interface [polypeptide binding]; other site
488223004583	dimer interface [polypeptide binding]; other site
488223004584	TPP binding site [chemical binding]; other site
488223004585	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
488223004586	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
488223004587	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
488223004588	substrate binding site [chemical binding]; other site
488223004589	hexamer interface [polypeptide binding]; other site
488223004590	metal binding site [ion binding]; metal-binding site
488223004591	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
488223004592	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
488223004593	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
488223004594	active site
488223004595	phosphorylation site [posttranslational modification]
488223004596	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
488223004597	active site
488223004598	phosphorylation site [posttranslational modification]
488223004599	HTH domain; Region: HTH_11; pfam08279
488223004600	Mga helix-turn-helix domain; Region: Mga; pfam05043
488223004601	PRD domain; Region: PRD; pfam00874
488223004602	PRD domain; Region: PRD; pfam00874
488223004603	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
488223004604	active site
488223004605	P-loop; other site
488223004606	phosphorylation site [posttranslational modification]
488223004607	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
488223004608	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
488223004609	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
488223004610	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223004611	motif II; other site
488223004612	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
488223004613	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
488223004614	putative acyl-acceptor binding pocket; other site
488223004615	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
488223004616	Cadmium resistance transporter; Region: Cad; pfam03596
488223004617	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
488223004618	16S/18S rRNA binding site [nucleotide binding]; other site
488223004619	S13e-L30e interaction site [polypeptide binding]; other site
488223004620	25S rRNA binding site [nucleotide binding]; other site
488223004621	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
488223004622	NADH(P)-binding; Region: NAD_binding_10; pfam13460
488223004623	NAD binding site [chemical binding]; other site
488223004624	substrate binding site [chemical binding]; other site
488223004625	putative active site [active]
488223004626	T-box leader; cis-reg00002
488223004627	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
488223004628	metal binding site [ion binding]; metal-binding site
488223004629	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
488223004630	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
488223004631	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
488223004632	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
488223004633	active site
488223004634	dimer interface [polypeptide binding]; other site
488223004635	motif 1; other site
488223004636	motif 2; other site
488223004637	motif 3; other site
488223004638	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
488223004639	anticodon binding site; other site
488223004640	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
488223004641	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223004642	ATP binding site [chemical binding]; other site
488223004643	Mg2+ binding site [ion binding]; other site
488223004644	G-X-G motif; other site
488223004645	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
488223004646	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488223004647	active site
488223004648	phosphorylation site [posttranslational modification]
488223004649	intermolecular recognition site; other site
488223004650	dimerization interface [polypeptide binding]; other site
488223004651	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488223004652	DNA binding site [nucleotide binding]
488223004653	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
488223004654	nucleophilic elbow; other site
488223004655	catalytic triad; other site
488223004656	Predicted transcriptional regulator [Transcription]; Region: COG1959
488223004657	Transcriptional regulator; Region: Rrf2; pfam02082
488223004658	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
488223004659	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
488223004660	active site
488223004661	metal binding site [ion binding]; metal-binding site
488223004662	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
488223004663	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
488223004664	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
488223004665	FeoA domain; Region: FeoA; pfam04023
488223004666	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
488223004667	putative active site [active]
488223004668	dimerization interface [polypeptide binding]; other site
488223004669	putative tRNAtyr binding site [nucleotide binding]; other site
488223004670	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
488223004671	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
488223004672	Zn2+ binding site [ion binding]; other site
488223004673	Mg2+ binding site [ion binding]; other site
488223004674	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
488223004675	synthetase active site [active]
488223004676	NTP binding site [chemical binding]; other site
488223004677	metal binding site [ion binding]; metal-binding site
488223004678	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
488223004679	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
488223004680	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
488223004681	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
488223004682	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
488223004683	active site
488223004684	Zn binding site [ion binding]; other site
488223004685	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
488223004686	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
488223004687	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
488223004688	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
488223004689	ABC-ATPase subunit  interface; other site
488223004690	dimer interface [polypeptide binding]; other site
488223004691	putative PBP binding regions; other site
488223004692	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
488223004693	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
488223004694	metal binding site [ion binding]; metal-binding site
488223004695	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
488223004696	dimer interface [polypeptide binding]; other site
488223004697	catalytic triad [active]
488223004698	peroxidatic and resolving cysteines [active]
488223004699	FtsX-like permease family; Region: FtsX; pfam02687
488223004700	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
488223004701	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
488223004702	FtsX-like permease family; Region: FtsX; pfam02687
488223004703	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
488223004704	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
488223004705	Walker A/P-loop; other site
488223004706	ATP binding site [chemical binding]; other site
488223004707	Q-loop/lid; other site
488223004708	ABC transporter signature motif; other site
488223004709	Walker B; other site
488223004710	D-loop; other site
488223004711	H-loop/switch region; other site
488223004712	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
488223004713	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
488223004714	catalytic core [active]
488223004715	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
488223004716	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
488223004717	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
488223004718	active site
488223004719	HIGH motif; other site
488223004720	nucleotide binding site [chemical binding]; other site
488223004721	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
488223004722	active site
488223004723	KMSKS motif; other site
488223004724	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
488223004725	tRNA binding surface [nucleotide binding]; other site
488223004726	anticodon binding site; other site
488223004727	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
488223004728	T-box leader; cis-reg00005
488223004729	DivIVA domain; Region: DivI1A_domain; TIGR03544
488223004730	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
488223004731	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
488223004732	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
488223004733	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
488223004734	RNA binding surface [nucleotide binding]; other site
488223004735	YGGT family; Region: YGGT; pfam02325
488223004736	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
488223004737	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
488223004738	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
488223004739	catalytic residue [active]
488223004740	cell division protein FtsZ; Validated; Region: PRK09330
488223004741	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
488223004742	nucleotide binding site [chemical binding]; other site
488223004743	SulA interaction site; other site
488223004744	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
488223004745	Cell division protein FtsA; Region: FtsA; smart00842
488223004746	Cell division protein FtsA; Region: FtsA; pfam14450
488223004747	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
488223004748	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
488223004749	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
488223004750	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
488223004751	nudix motif; other site
488223004752	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
488223004753	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
488223004754	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
488223004755	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
488223004756	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
488223004757	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
488223004758	recombination protein RecR; Reviewed; Region: recR; PRK00076
488223004759	RecR protein; Region: RecR; pfam02132
488223004760	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
488223004761	putative active site [active]
488223004762	putative metal-binding site [ion binding]; other site
488223004763	tetramer interface [polypeptide binding]; other site
488223004764	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
488223004765	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
488223004766	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
488223004767	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
488223004768	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
488223004769	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
488223004770	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
488223004771	putative active site [active]
488223004772	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
488223004773	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
488223004774	nucleotide binding site [chemical binding]; other site
488223004775	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
488223004776	Class I aldolases; Region: Aldolase_Class_I; cl17187
488223004777	catalytic residue [active]
488223004778	Protein of unknown function, DUF624; Region: DUF624; pfam04854
488223004779	Domain of unknown function (DUF386); Region: DUF386; pfam04074
488223004780	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
488223004781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223004782	dimer interface [polypeptide binding]; other site
488223004783	conserved gate region; other site
488223004784	putative PBP binding loops; other site
488223004785	ABC-ATPase subunit interface; other site
488223004786	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
488223004787	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
488223004788	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223004789	putative PBP binding loops; other site
488223004790	dimer interface [polypeptide binding]; other site
488223004791	ABC-ATPase subunit interface; other site
488223004792	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
488223004793	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
488223004794	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
488223004795	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
488223004796	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
488223004797	active site turn [active]
488223004798	phosphorylation site [posttranslational modification]
488223004799	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
488223004800	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
488223004801	putative active site cavity [active]
488223004802	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
488223004803	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
488223004804	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
488223004805	Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409
488223004806	Sialidase, N-terminal domain; Region: Sialidase; pfam02973
488223004807	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
488223004808	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
488223004809	Asp-box motif; other site
488223004810	catalytic site [active]
488223004811	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
488223004812	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223004813	dimer interface [polypeptide binding]; other site
488223004814	conserved gate region; other site
488223004815	putative PBP binding loops; other site
488223004816	ABC-ATPase subunit interface; other site
488223004817	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
488223004818	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223004819	dimer interface [polypeptide binding]; other site
488223004820	conserved gate region; other site
488223004821	putative PBP binding loops; other site
488223004822	ABC-ATPase subunit interface; other site
488223004823	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
488223004824	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
488223004825	Domain of unknown function (DUF386); Region: DUF386; cl01047
488223004826	Sialidase, N-terminal domain; Region: Sialidase; pfam02973
488223004827	calcium mediated ligand binding site; other site
488223004828	intermolecular salt bridges; other site
488223004829	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
488223004830	Asp-box motif; other site
488223004831	catalytic site [active]
488223004832	Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887
488223004833	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
488223004834	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
488223004835	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
488223004836	ssDNA binding site; other site
488223004837	generic binding surface II; other site
488223004838	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488223004839	ATP binding site [chemical binding]; other site
488223004840	putative Mg++ binding site [ion binding]; other site
488223004841	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488223004842	nucleotide binding region [chemical binding]; other site
488223004843	ATP-binding site [chemical binding]; other site
488223004844	alanine racemase; Reviewed; Region: alr; PRK00053
488223004845	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
488223004846	active site
488223004847	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
488223004848	dimer interface [polypeptide binding]; other site
488223004849	substrate binding site [chemical binding]; other site
488223004850	catalytic residues [active]
488223004851	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
488223004852	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
488223004853	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
488223004854	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
488223004855	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
488223004856	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
488223004857	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
488223004858	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488223004859	nucleotide binding region [chemical binding]; other site
488223004860	ATP-binding site [chemical binding]; other site
488223004861	SEC-C motif; Region: SEC-C; pfam02810
488223004862	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
488223004863	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
488223004864	Walker A/P-loop; other site
488223004865	ATP binding site [chemical binding]; other site
488223004866	Q-loop/lid; other site
488223004867	ABC transporter signature motif; other site
488223004868	Walker B; other site
488223004869	D-loop; other site
488223004870	H-loop/switch region; other site
488223004871	GTP-binding protein Der; Reviewed; Region: PRK00093
488223004872	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
488223004873	G1 box; other site
488223004874	GTP/Mg2+ binding site [chemical binding]; other site
488223004875	Switch I region; other site
488223004876	G2 box; other site
488223004877	Switch II region; other site
488223004878	G3 box; other site
488223004879	G4 box; other site
488223004880	G5 box; other site
488223004881	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
488223004882	G1 box; other site
488223004883	GTP/Mg2+ binding site [chemical binding]; other site
488223004884	Switch I region; other site
488223004885	G2 box; other site
488223004886	G3 box; other site
488223004887	Switch II region; other site
488223004888	G4 box; other site
488223004889	G5 box; other site
488223004890	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
488223004891	dimer interface [polypeptide binding]; other site
488223004892	FMN binding site [chemical binding]; other site
488223004893	NADPH bind site [chemical binding]; other site
488223004894	primosomal protein DnaI; Reviewed; Region: PRK08939
488223004895	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
488223004896	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223004897	Walker A motif; other site
488223004898	ATP binding site [chemical binding]; other site
488223004899	Walker B motif; other site
488223004900	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
488223004901	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
488223004902	ATP cone domain; Region: ATP-cone; pfam03477
488223004903	Predicted transcriptional regulators [Transcription]; Region: COG1725
488223004904	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
488223004905	DNA-binding site [nucleotide binding]; DNA binding site
488223004906	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
488223004907	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
488223004908	Walker A/P-loop; other site
488223004909	ATP binding site [chemical binding]; other site
488223004910	Q-loop/lid; other site
488223004911	ABC transporter signature motif; other site
488223004912	Walker B; other site
488223004913	D-loop; other site
488223004914	H-loop/switch region; other site
488223004915	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
488223004916	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
488223004917	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223004918	Walker A/P-loop; other site
488223004919	ATP binding site [chemical binding]; other site
488223004920	Q-loop/lid; other site
488223004921	ABC transporter signature motif; other site
488223004922	Walker B; other site
488223004923	D-loop; other site
488223004924	H-loop/switch region; other site
488223004925	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
488223004926	Uncharacterized conserved protein [Function unknown]; Region: COG0398
488223004927	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
488223004928	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
488223004929	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
488223004930	nucleotide binding site [chemical binding]; other site
488223004931	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
488223004932	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
488223004933	active site turn [active]
488223004934	phosphorylation site [posttranslational modification]
488223004935	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
488223004936	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
488223004937	HPr interaction site; other site
488223004938	glycerol kinase (GK) interaction site [polypeptide binding]; other site
488223004939	active site
488223004940	phosphorylation site [posttranslational modification]
488223004941	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
488223004942	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
488223004943	substrate binding [chemical binding]; other site
488223004944	active site
488223004945	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
488223004946	Transcriptional regulators [Transcription]; Region: PurR; COG1609
488223004947	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
488223004948	DNA binding site [nucleotide binding]
488223004949	domain linker motif; other site
488223004950	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
488223004951	dimerization interface [polypeptide binding]; other site
488223004952	ligand binding site [chemical binding]; other site
488223004953	sodium binding site [ion binding]; other site
488223004954	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
488223004955	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
488223004956	dimer interface [polypeptide binding]; other site
488223004957	active site
488223004958	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
488223004959	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
488223004960	Uncharacterized conserved protein [Function unknown]; Region: COG3610
488223004961	Uncharacterized conserved protein [Function unknown]; Region: COG2966
488223004962	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
488223004963	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
488223004964	Catalytic domain of Protein Kinases; Region: PKc; cd00180
488223004965	active site
488223004966	ATP binding site [chemical binding]; other site
488223004967	substrate binding site [chemical binding]; other site
488223004968	activation loop (A-loop); other site
488223004969	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
488223004970	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
488223004971	PASTA domain; Region: PASTA; smart00740
488223004972	PASTA domain; Region: PASTA; smart00740
488223004973	PASTA domain; Region: PASTA; smart00740
488223004974	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
488223004975	active site
488223004976	16S rRNA methyltransferase B; Provisional; Region: PRK14902
488223004977	NusB family; Region: NusB; pfam01029
488223004978	putative RNA binding site [nucleotide binding]; other site
488223004979	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223004980	S-adenosylmethionine binding site [chemical binding]; other site
488223004981	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
488223004982	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
488223004983	putative active site [active]
488223004984	substrate binding site [chemical binding]; other site
488223004985	putative cosubstrate binding site; other site
488223004986	catalytic site [active]
488223004987	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
488223004988	substrate binding site [chemical binding]; other site
488223004989	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
488223004990	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488223004991	ATP binding site [chemical binding]; other site
488223004992	putative Mg++ binding site [ion binding]; other site
488223004993	helicase superfamily c-terminal domain; Region: HELICc; smart00490
488223004994	ATP-binding site [chemical binding]; other site
488223004995	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
488223004996	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
488223004997	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
488223004998	catalytic site [active]
488223004999	G-X2-G-X-G-K; other site
488223005000	hypothetical protein; Provisional; Region: PRK00106
488223005001	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
488223005002	Zn2+ binding site [ion binding]; other site
488223005003	Mg2+ binding site [ion binding]; other site
488223005004	SIR2-like domain; Region: SIR2_2; pfam13289
488223005005	hypothetical protein; Provisional; Region: PRK13670
488223005006	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
488223005007	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
488223005008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223005009	S-adenosylmethionine binding site [chemical binding]; other site
488223005010	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
488223005011	Isochorismatase family; Region: Isochorismatase; pfam00857
488223005012	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
488223005013	catalytic triad [active]
488223005014	conserved cis-peptide bond; other site
488223005015	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
488223005016	Zn2+ binding site [ion binding]; other site
488223005017	Mg2+ binding site [ion binding]; other site
488223005018	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
488223005019	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
488223005020	active site
488223005021	(T/H)XGH motif; other site
488223005022	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
488223005023	GTPase YqeH; Provisional; Region: PRK13796
488223005024	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
488223005025	GTP/Mg2+ binding site [chemical binding]; other site
488223005026	G4 box; other site
488223005027	G5 box; other site
488223005028	G1 box; other site
488223005029	Switch I region; other site
488223005030	G2 box; other site
488223005031	G3 box; other site
488223005032	Switch II region; other site
488223005033	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
488223005034	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223005035	active site
488223005036	motif I; other site
488223005037	motif II; other site
488223005038	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
488223005039	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
488223005040	Cl binding site [ion binding]; other site
488223005041	oligomer interface [polypeptide binding]; other site
488223005042	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
488223005043	Mechanosensitive ion channel; Region: MS_channel; pfam00924
488223005044	Predicted membrane protein [Function unknown]; Region: COG4129
488223005045	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
488223005046	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
488223005047	MarR family; Region: MarR; pfam01047
488223005048	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
488223005049	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
488223005050	catalytic residues [active]
488223005051	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
488223005052	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
488223005053	amphipathic channel; other site
488223005054	Asn-Pro-Ala signature motifs; other site
488223005055	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
488223005056	ABC-2 type transporter; Region: ABC2_membrane; cl17235
488223005057	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
488223005058	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223005059	Walker A/P-loop; other site
488223005060	ATP binding site [chemical binding]; other site
488223005061	Q-loop/lid; other site
488223005062	ABC transporter signature motif; other site
488223005063	Walker B; other site
488223005064	D-loop; other site
488223005065	H-loop/switch region; other site
488223005066	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
488223005067	dimerization interface [polypeptide binding]; other site
488223005068	putative DNA binding site [nucleotide binding]; other site
488223005069	putative Zn2+ binding site [ion binding]; other site
488223005070	oligoendopeptidase F; Region: pepF; TIGR00181
488223005071	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
488223005072	Zn binding site [ion binding]; other site
488223005073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
488223005074	RNA methyltransferase, RsmE family; Region: TIGR00046
488223005075	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
488223005076	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223005077	S-adenosylmethionine binding site [chemical binding]; other site
488223005078	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
488223005079	nudix motif; other site
488223005080	Peptidase family M50; Region: Peptidase_M50; pfam02163
488223005081	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
488223005082	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
488223005083	recombination factor protein RarA; Reviewed; Region: PRK13342
488223005084	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223005085	Walker A motif; other site
488223005086	ATP binding site [chemical binding]; other site
488223005087	Walker B motif; other site
488223005088	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
488223005089	arginine finger; other site
488223005090	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
488223005091	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
488223005092	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
488223005093	substrate binding [chemical binding]; other site
488223005094	active site
488223005095	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
488223005096	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
488223005097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223005098	dimer interface [polypeptide binding]; other site
488223005099	conserved gate region; other site
488223005100	putative PBP binding loops; other site
488223005101	ABC-ATPase subunit interface; other site
488223005102	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
488223005103	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223005104	dimer interface [polypeptide binding]; other site
488223005105	conserved gate region; other site
488223005106	putative PBP binding loops; other site
488223005107	ABC-ATPase subunit interface; other site
488223005108	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
488223005109	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
488223005110	Transcriptional regulators [Transcription]; Region: PurR; COG1609
488223005111	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
488223005112	DNA binding site [nucleotide binding]
488223005113	domain linker motif; other site
488223005114	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
488223005115	dimerization interface [polypeptide binding]; other site
488223005116	ligand binding site [chemical binding]; other site
488223005117	sodium binding site [ion binding]; other site
488223005118	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
488223005119	Mga helix-turn-helix domain; Region: Mga; pfam05043
488223005120	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
488223005121	Predicted membrane protein [Function unknown]; Region: COG2261
488223005122	Small integral membrane protein [Function unknown]; Region: COG5547
488223005123	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
488223005124	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
488223005125	Uncharacterized conserved protein [Function unknown]; Region: COG1262
488223005126	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
488223005127	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
488223005128	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
488223005129	active site
488223005130	P-loop; other site
488223005131	phosphorylation site [posttranslational modification]
488223005132	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270
488223005133	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
488223005134	MarR family; Region: MarR_2; pfam12802
488223005135	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
488223005136	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
488223005137	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
488223005138	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488223005139	Coenzyme A binding pocket [chemical binding]; other site
488223005140	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
488223005141	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
488223005142	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
488223005143	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488223005144	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223005145	non-specific DNA binding site [nucleotide binding]; other site
488223005146	salt bridge; other site
488223005147	sequence-specific DNA binding site [nucleotide binding]; other site
488223005148	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
488223005149	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
488223005150	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
488223005151	substrate binding site [chemical binding]; other site
488223005152	active site
488223005153	catalytic residues [active]
488223005154	heterodimer interface [polypeptide binding]; other site
488223005155	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
488223005156	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
488223005157	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488223005158	catalytic residue [active]
488223005159	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
488223005160	active site
488223005161	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
488223005162	active site
488223005163	ribulose/triose binding site [chemical binding]; other site
488223005164	phosphate binding site [ion binding]; other site
488223005165	substrate (anthranilate) binding pocket [chemical binding]; other site
488223005166	product (indole) binding pocket [chemical binding]; other site
488223005167	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
488223005168	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
488223005169	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
488223005170	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
488223005171	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
488223005172	glutamine binding [chemical binding]; other site
488223005173	catalytic triad [active]
488223005174	anthranilate synthase component I; Provisional; Region: PRK13570
488223005175	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
488223005176	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
488223005177	T-box leader; cis-reg00003
488223005178	T-box leader; cis-reg00004
488223005179	Transcriptional regulators [Transcription]; Region: PurR; COG1609
488223005180	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
488223005181	DNA binding site [nucleotide binding]
488223005182	domain linker motif; other site
488223005183	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
488223005184	putative dimerization interface [polypeptide binding]; other site
488223005185	putative ligand binding site [chemical binding]; other site
488223005186	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
488223005187	MgtC family; Region: MgtC; pfam02308
488223005188	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
488223005189	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223005190	dimer interface [polypeptide binding]; other site
488223005191	conserved gate region; other site
488223005192	putative PBP binding loops; other site
488223005193	ABC-ATPase subunit interface; other site
488223005194	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223005195	putative PBP binding loops; other site
488223005196	dimer interface [polypeptide binding]; other site
488223005197	ABC-ATPase subunit interface; other site
488223005198	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
488223005199	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223005200	Walker A/P-loop; other site
488223005201	ATP binding site [chemical binding]; other site
488223005202	Q-loop/lid; other site
488223005203	ABC transporter signature motif; other site
488223005204	Walker B; other site
488223005205	D-loop; other site
488223005206	H-loop/switch region; other site
488223005207	TOBE domain; Region: TOBE; pfam03459
488223005208	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
488223005209	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
488223005210	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255
488223005211	Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975
488223005212	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
488223005213	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
488223005214	Pectate lyase; Region: Pec_lyase_C; cl01593
488223005215	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
488223005216	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
488223005217	inhibitor-cofactor binding pocket; inhibition site
488223005218	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488223005219	catalytic residue [active]
488223005220	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
488223005221	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
488223005222	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488223005223	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
488223005224	Walker A/P-loop; other site
488223005225	ATP binding site [chemical binding]; other site
488223005226	Q-loop/lid; other site
488223005227	ABC transporter signature motif; other site
488223005228	Walker B; other site
488223005229	D-loop; other site
488223005230	H-loop/switch region; other site
488223005231	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488223005232	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
488223005233	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223005234	Walker A/P-loop; other site
488223005235	ATP binding site [chemical binding]; other site
488223005236	Q-loop/lid; other site
488223005237	ABC transporter signature motif; other site
488223005238	Walker B; other site
488223005239	D-loop; other site
488223005240	H-loop/switch region; other site
488223005241	Predicted membrane protein [Function unknown]; Region: COG2323
488223005242	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
488223005243	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
488223005244	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
488223005245	active site
488223005246	putative catalytic site [active]
488223005247	DNA binding site [nucleotide binding]
488223005248	putative phosphate binding site [ion binding]; other site
488223005249	metal binding site A [ion binding]; metal-binding site
488223005250	AP binding site [nucleotide binding]; other site
488223005251	metal binding site B [ion binding]; metal-binding site
488223005252	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488223005253	active site
488223005254	xanthine permease; Region: pbuX; TIGR03173
488223005255	Sulfate transporter family; Region: Sulfate_transp; pfam00916
488223005256	DpnII restriction endonuclease; Region: DpnII; pfam04556
488223005257	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
488223005258	DNA methylase; Region: N6_N4_Mtase; pfam01555
488223005259	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223005260	S-adenosylmethionine binding site [chemical binding]; other site
488223005261	DNA adenine methylase (dam); Region: dam; TIGR00571
488223005262	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
488223005263	CoenzymeA binding site [chemical binding]; other site
488223005264	subunit interaction site [polypeptide binding]; other site
488223005265	PHB binding site; other site
488223005266	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
488223005267	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
488223005268	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
488223005269	galactokinase; Provisional; Region: PRK05322
488223005270	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
488223005271	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
488223005272	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
488223005273	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
488223005274	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
488223005275	DNA binding site [nucleotide binding]
488223005276	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
488223005277	putative dimerization interface [polypeptide binding]; other site
488223005278	putative ligand binding site [chemical binding]; other site
488223005279	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
488223005280	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
488223005281	catalytic Zn binding site [ion binding]; other site
488223005282	NAD(P) binding site [chemical binding]; other site
488223005283	structural Zn binding site [ion binding]; other site
488223005284	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
488223005285	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
488223005286	DNA binding residues [nucleotide binding]
488223005287	putative dimer interface [polypeptide binding]; other site
488223005288	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
488223005289	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
488223005290	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
488223005291	nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528
488223005292	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
488223005293	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223005294	dimer interface [polypeptide binding]; other site
488223005295	conserved gate region; other site
488223005296	ABC-ATPase subunit interface; other site
488223005297	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
488223005298	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
488223005299	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
488223005300	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223005301	Walker A/P-loop; other site
488223005302	ATP binding site [chemical binding]; other site
488223005303	Q-loop/lid; other site
488223005304	ABC transporter signature motif; other site
488223005305	Walker B; other site
488223005306	D-loop; other site
488223005307	H-loop/switch region; other site
488223005308	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
488223005309	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
488223005310	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
488223005311	Enterocin A Immunity; Region: EntA_Immun; pfam08951
488223005312	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
488223005313	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
488223005314	oligomer interface [polypeptide binding]; other site
488223005315	active site
488223005316	metal binding site [ion binding]; metal-binding site
488223005317	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
488223005318	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
488223005319	ABC-ATPase subunit  interface; other site
488223005320	dimer interface [polypeptide binding]; other site
488223005321	putative PBP binding regions; other site
488223005322	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
488223005323	ABC-ATPase subunit  interface; other site
488223005324	dimer interface [polypeptide binding]; other site
488223005325	putative PBP binding regions; other site
488223005326	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
488223005327	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
488223005328	Walker A/P-loop; other site
488223005329	ATP binding site [chemical binding]; other site
488223005330	Q-loop/lid; other site
488223005331	ABC transporter signature motif; other site
488223005332	Walker B; other site
488223005333	D-loop; other site
488223005334	H-loop/switch region; other site
488223005335	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
488223005336	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
488223005337	putative ligand binding residues [chemical binding]; other site
488223005338	hypothetical protein; Validated; Region: PRK00041
488223005339	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
488223005340	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
488223005341	RNA binding surface [nucleotide binding]; other site
488223005342	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
488223005343	active site
488223005344	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
488223005345	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
488223005346	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
488223005347	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
488223005348	DNA binding site [nucleotide binding]
488223005349	Int/Topo IB signature motif; other site
488223005350	active site
488223005351	catalytic residues [active]
488223005352	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
488223005353	FOG: CBS domain [General function prediction only]; Region: COG0517
488223005354	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
488223005355	active site
488223005356	metal binding site [ion binding]; metal-binding site
488223005357	homotetramer interface [polypeptide binding]; other site
488223005358	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
488223005359	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
488223005360	active site
488223005361	dimerization interface [polypeptide binding]; other site
488223005362	glutamate racemase; Provisional; Region: PRK00865
488223005363	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
488223005364	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
488223005365	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
488223005366	Ca binding site [ion binding]; other site
488223005367	active site
488223005368	catalytic site [active]
488223005369	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
488223005370	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
488223005371	active site turn [active]
488223005372	phosphorylation site [posttranslational modification]
488223005373	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
488223005374	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
488223005375	HPr interaction site; other site
488223005376	glycerol kinase (GK) interaction site [polypeptide binding]; other site
488223005377	active site
488223005378	phosphorylation site [posttranslational modification]
488223005379	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
488223005380	DNA-binding site [nucleotide binding]; DNA binding site
488223005381	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
488223005382	UTRA domain; Region: UTRA; pfam07702
488223005383	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
488223005384	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223005385	Walker A/P-loop; other site
488223005386	ATP binding site [chemical binding]; other site
488223005387	Q-loop/lid; other site
488223005388	ABC transporter signature motif; other site
488223005389	Walker B; other site
488223005390	D-loop; other site
488223005391	H-loop/switch region; other site
488223005392	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
488223005393	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
488223005394	Walker A/P-loop; other site
488223005395	ATP binding site [chemical binding]; other site
488223005396	Q-loop/lid; other site
488223005397	ABC transporter signature motif; other site
488223005398	Walker B; other site
488223005399	D-loop; other site
488223005400	H-loop/switch region; other site
488223005401	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
488223005402	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
488223005403	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
488223005404	Walker A/P-loop; other site
488223005405	ATP binding site [chemical binding]; other site
488223005406	Q-loop/lid; other site
488223005407	ABC transporter signature motif; other site
488223005408	Walker B; other site
488223005409	D-loop; other site
488223005410	H-loop/switch region; other site
488223005411	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
488223005412	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
488223005413	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
488223005414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223005415	dimer interface [polypeptide binding]; other site
488223005416	conserved gate region; other site
488223005417	putative PBP binding loops; other site
488223005418	ABC-ATPase subunit interface; other site
488223005419	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
488223005420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223005421	dimer interface [polypeptide binding]; other site
488223005422	conserved gate region; other site
488223005423	putative PBP binding loops; other site
488223005424	ABC-ATPase subunit interface; other site
488223005425	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
488223005426	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
488223005427	peptide binding site [polypeptide binding]; other site
488223005428	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
488223005429	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
488223005430	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
488223005431	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
488223005432	active site
488223005433	homodimer interface [polypeptide binding]; other site
488223005434	catalytic site [active]
488223005435	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
488223005436	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223005437	dimer interface [polypeptide binding]; other site
488223005438	conserved gate region; other site
488223005439	putative PBP binding loops; other site
488223005440	ABC-ATPase subunit interface; other site
488223005441	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223005442	dimer interface [polypeptide binding]; other site
488223005443	conserved gate region; other site
488223005444	putative PBP binding loops; other site
488223005445	ABC-ATPase subunit interface; other site
488223005446	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
488223005447	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
488223005448	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
488223005449	Melibiase; Region: Melibiase; pfam02065
488223005450	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
488223005451	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
488223005452	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
488223005453	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
488223005454	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
488223005455	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
488223005456	DNA-binding site [nucleotide binding]; DNA binding site
488223005457	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
488223005458	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
488223005459	TRAM domain; Region: TRAM; pfam01938
488223005460	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
488223005461	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223005462	S-adenosylmethionine binding site [chemical binding]; other site
488223005463	Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150
488223005464	active site
488223005465	Phosphotransferase enzyme family; Region: APH; pfam01636
488223005466	ATP binding site [chemical binding]; other site
488223005467	antibiotic binding site [chemical binding]; other site
488223005468	recombination regulator RecX; Provisional; Region: recX; PRK14135
488223005469	hypothetical protein; Provisional; Region: PRK13662
488223005470	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
488223005471	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
488223005472	ring oligomerisation interface [polypeptide binding]; other site
488223005473	ATP/Mg binding site [chemical binding]; other site
488223005474	stacking interactions; other site
488223005475	hinge regions; other site
488223005476	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
488223005477	oligomerisation interface [polypeptide binding]; other site
488223005478	mobile loop; other site
488223005479	roof hairpin; other site
488223005480	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
488223005481	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
488223005482	dimer interface [polypeptide binding]; other site
488223005483	ssDNA binding site [nucleotide binding]; other site
488223005484	tetramer (dimer of dimers) interface [polypeptide binding]; other site
488223005485	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
488223005486	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
488223005487	putative NAD(P) binding site [chemical binding]; other site
488223005488	homodimer interface [polypeptide binding]; other site
488223005489	homotetramer interface [polypeptide binding]; other site
488223005490	active site
488223005491	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
488223005492	putative tRNA-binding site [nucleotide binding]; other site
488223005493	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
488223005494	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
488223005495	catalytic residues [active]
488223005496	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
488223005497	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
488223005498	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
488223005499	LytTr DNA-binding domain; Region: LytTR; smart00850
488223005500	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
488223005501	active site
488223005502	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
488223005503	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4898
488223005504	hypothetical protein; Provisional; Region: PRK12378
488223005505	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
488223005506	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
488223005507	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
488223005508	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
488223005509	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488223005510	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223005511	non-specific DNA binding site [nucleotide binding]; other site
488223005512	salt bridge; other site
488223005513	sequence-specific DNA binding site [nucleotide binding]; other site
488223005514	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
488223005515	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
488223005516	amidase catalytic site [active]
488223005517	Zn binding residues [ion binding]; other site
488223005518	substrate binding site [chemical binding]; other site
488223005519	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223005520	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223005521	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
488223005522	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
488223005523	recombinase A; Provisional; Region: recA; PRK09354
488223005524	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
488223005525	hexamer interface [polypeptide binding]; other site
488223005526	Walker A motif; other site
488223005527	ATP binding site [chemical binding]; other site
488223005528	Walker B motif; other site
488223005529	competence damage-inducible protein A; Provisional; Region: PRK00549
488223005530	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
488223005531	putative MPT binding site; other site
488223005532	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
488223005533	Transcriptional regulator [Transcription]; Region: LytR; COG1316
488223005534	putative acetyltransferase YhhY; Provisional; Region: PRK10140
488223005535	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
488223005536	Coenzyme A binding pocket [chemical binding]; other site
488223005537	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
488223005538	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488223005539	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223005540	non-specific DNA binding site [nucleotide binding]; other site
488223005541	salt bridge; other site
488223005542	sequence-specific DNA binding site [nucleotide binding]; other site
488223005543	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
488223005544	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
488223005545	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
488223005546	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
488223005547	Walker A/P-loop; other site
488223005548	ATP binding site [chemical binding]; other site
488223005549	Q-loop/lid; other site
488223005550	ABC transporter signature motif; other site
488223005551	Walker B; other site
488223005552	D-loop; other site
488223005553	H-loop/switch region; other site
488223005554	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
488223005555	active site
488223005556	multimer interface [polypeptide binding]; other site
488223005557	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
488223005558	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
488223005559	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
488223005560	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
488223005561	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
488223005562	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
488223005563	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
488223005564	G-loop; other site
488223005565	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
488223005566	DNA binding site [nucleotide binding]
488223005567	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
488223005568	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
488223005569	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
488223005570	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
488223005571	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
488223005572	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
488223005573	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
488223005574	RPB1 interaction site [polypeptide binding]; other site
488223005575	RPB10 interaction site [polypeptide binding]; other site
488223005576	RPB11 interaction site [polypeptide binding]; other site
488223005577	RPB3 interaction site [polypeptide binding]; other site
488223005578	RPB12 interaction site [polypeptide binding]; other site
488223005579	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
488223005580	Domain of unknown function DUF21; Region: DUF21; pfam01595
488223005581	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
488223005582	Transporter associated domain; Region: CorC_HlyC; smart01091
488223005583	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
488223005584	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
488223005585	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
488223005586	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
488223005587	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
488223005588	hinge; other site
488223005589	active site
488223005590	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
488223005591	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
488223005592	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
488223005593	protein binding site [polypeptide binding]; other site
488223005594	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
488223005595	Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669
488223005596	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
488223005597	active site
488223005598	(T/H)XGH motif; other site
488223005599	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
488223005600	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223005601	S-adenosylmethionine binding site [chemical binding]; other site
488223005602	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
488223005603	dimer interface [polypeptide binding]; other site
488223005604	active site
488223005605	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
488223005606	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
488223005607	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
488223005608	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
488223005609	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
488223005610	acylphosphatase; Provisional; Region: PRK14434
488223005611	OxaA-like protein precursor; Provisional; Region: PRK02463
488223005612	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
488223005613	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
488223005614	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
488223005615	FeS/SAM binding site; other site
488223005616	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
488223005617	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
488223005618	active site
488223005619	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
488223005620	substrate binding site [chemical binding]; other site
488223005621	catalytic residues [active]
488223005622	dimer interface [polypeptide binding]; other site
488223005623	pur operon repressor; Provisional; Region: PRK09213
488223005624	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
488223005625	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488223005626	active site
488223005627	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
488223005628	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
488223005629	generic binding surface II; other site
488223005630	generic binding surface I; other site
488223005631	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
488223005632	Zn2+ binding site [ion binding]; other site
488223005633	Mg2+ binding site [ion binding]; other site
488223005634	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
488223005635	RmuC family; Region: RmuC; pfam02646
488223005636	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
488223005637	Thiamine pyrophosphokinase; Region: TPK; cd07995
488223005638	active site
488223005639	dimerization interface [polypeptide binding]; other site
488223005640	thiamine binding site [chemical binding]; other site
488223005641	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
488223005642	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
488223005643	substrate binding site [chemical binding]; other site
488223005644	hexamer interface [polypeptide binding]; other site
488223005645	metal binding site [ion binding]; metal-binding site
488223005646	GTPase RsgA; Reviewed; Region: PRK00098
488223005647	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
488223005648	RNA binding site [nucleotide binding]; other site
488223005649	homodimer interface [polypeptide binding]; other site
488223005650	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
488223005651	GTPase/Zn-binding domain interface [polypeptide binding]; other site
488223005652	GTP/Mg2+ binding site [chemical binding]; other site
488223005653	G4 box; other site
488223005654	G5 box; other site
488223005655	G1 box; other site
488223005656	Switch I region; other site
488223005657	G2 box; other site
488223005658	G3 box; other site
488223005659	Switch II region; other site
488223005660	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
488223005661	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223005662	S-adenosylmethionine binding site [chemical binding]; other site
488223005663	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
488223005664	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
488223005665	Walker A/P-loop; other site
488223005666	ATP binding site [chemical binding]; other site
488223005667	Q-loop/lid; other site
488223005668	ABC transporter signature motif; other site
488223005669	Walker B; other site
488223005670	D-loop; other site
488223005671	H-loop/switch region; other site
488223005672	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
488223005673	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223005674	non-specific DNA binding site [nucleotide binding]; other site
488223005675	salt bridge; other site
488223005676	sequence-specific DNA binding site [nucleotide binding]; other site
488223005677	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
488223005678	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
488223005679	putative active site [active]
488223005680	putative metal binding site [ion binding]; other site
488223005681	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
488223005682	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
488223005683	active site
488223005684	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
488223005685	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
488223005686	aminotransferase AlaT; Validated; Region: PRK09265
488223005687	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
488223005688	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488223005689	homodimer interface [polypeptide binding]; other site
488223005690	catalytic residue [active]
488223005691	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
488223005692	Ligand Binding Site [chemical binding]; other site
488223005693	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223005694	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
488223005695	active site
488223005696	motif I; other site
488223005697	motif II; other site
488223005698	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223005699	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
488223005700	putative nucleotide binding site [chemical binding]; other site
488223005701	putative metal binding site [ion binding]; other site
488223005702	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
488223005703	active site
488223005704	homotetramer interface [polypeptide binding]; other site
488223005705	homodimer interface [polypeptide binding]; other site
488223005706	catabolite control protein A; Region: ccpA; TIGR01481
488223005707	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
488223005708	DNA binding site [nucleotide binding]
488223005709	domain linker motif; other site
488223005710	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
488223005711	dimerization interface [polypeptide binding]; other site
488223005712	effector binding site; other site
488223005713	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
488223005714	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488223005715	active site
488223005716	phosphorylation site [posttranslational modification]
488223005717	intermolecular recognition site; other site
488223005718	dimerization interface [polypeptide binding]; other site
488223005719	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
488223005720	DNA binding residues [nucleotide binding]
488223005721	dimerization interface [polypeptide binding]; other site
488223005722	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
488223005723	Histidine kinase; Region: HisKA_3; pfam07730
488223005724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223005725	ATP binding site [chemical binding]; other site
488223005726	Mg2+ binding site [ion binding]; other site
488223005727	G-X-G motif; other site
488223005728	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
488223005729	ABC-2 type transporter; Region: ABC2_membrane; cl17235
488223005730	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
488223005731	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
488223005732	Walker A/P-loop; other site
488223005733	ATP binding site [chemical binding]; other site
488223005734	Q-loop/lid; other site
488223005735	ABC transporter signature motif; other site
488223005736	Walker B; other site
488223005737	D-loop; other site
488223005738	H-loop/switch region; other site
488223005739	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
488223005740	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
488223005741	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
488223005742	putative homodimer interface [polypeptide binding]; other site
488223005743	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
488223005744	heterodimer interface [polypeptide binding]; other site
488223005745	homodimer interface [polypeptide binding]; other site
488223005746	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
488223005747	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
488223005748	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
488223005749	Transglycosylase; Region: Transgly; pfam00912
488223005750	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
488223005751	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
488223005752	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
488223005753	active site
488223005754	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
488223005755	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
488223005756	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
488223005757	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
488223005758	FtsX-like permease family; Region: FtsX; pfam02687
488223005759	Transposase; Region: HTH_Tnp_IS630; pfam01710
488223005760	Helix-turn-helix domain; Region: HTH_28; pfam13518
488223005761	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559
488223005762	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
488223005763	dimerization interface [polypeptide binding]; other site
488223005764	active site
488223005765	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
488223005766	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
488223005767	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
488223005768	Walker A/P-loop; other site
488223005769	ATP binding site [chemical binding]; other site
488223005770	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
488223005771	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
488223005772	DNA-binding site [nucleotide binding]; DNA binding site
488223005773	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
488223005774	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
488223005775	beta-galactosidase; Region: BGL; TIGR03356
488223005776	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
488223005777	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
488223005778	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
488223005779	active site
488223005780	P-loop; other site
488223005781	phosphorylation site [posttranslational modification]
488223005782	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
488223005783	methionine cluster; other site
488223005784	active site
488223005785	phosphorylation site [posttranslational modification]
488223005786	metal binding site [ion binding]; metal-binding site
488223005787	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
488223005788	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
488223005789	putative catalytic cysteine [active]
488223005790	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
488223005791	putative active site [active]
488223005792	metal binding site [ion binding]; metal-binding site
488223005793	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
488223005794	MORN repeat; Region: MORN; cl14787
488223005795	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
488223005796	Low molecular weight phosphatase family; Region: LMWPc; cd00115
488223005797	active site
488223005798	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
488223005799	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
488223005800	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
488223005801	TPP-binding site [chemical binding]; other site
488223005802	dimer interface [polypeptide binding]; other site
488223005803	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
488223005804	PYR/PP interface [polypeptide binding]; other site
488223005805	dimer interface [polypeptide binding]; other site
488223005806	TPP binding site [chemical binding]; other site
488223005807	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
488223005808	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
488223005809	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
488223005810	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
488223005811	PRD domain; Region: PRD; pfam00874
488223005812	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
488223005813	active site
488223005814	P-loop; other site
488223005815	phosphorylation site [posttranslational modification]
488223005816	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
488223005817	L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145
488223005818	intersubunit interface [polypeptide binding]; other site
488223005819	active site
488223005820	Zn2+ binding site [ion binding]; other site
488223005821	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
488223005822	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
488223005823	AP (apurinic/apyrimidinic) site pocket; other site
488223005824	DNA interaction; other site
488223005825	Metal-binding active site; metal-binding site
488223005826	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
488223005827	active site
488223005828	dimer interface [polypeptide binding]; other site
488223005829	magnesium binding site [ion binding]; other site
488223005830	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
488223005831	active site
488223005832	phosphorylation site [posttranslational modification]
488223005833	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
488223005834	active site
488223005835	P-loop; other site
488223005836	phosphorylation site [posttranslational modification]
488223005837	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
488223005838	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
488223005839	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
488223005840	G-X-X-G motif; other site
488223005841	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
488223005842	RxxxH motif; other site
488223005843	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
488223005844	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
488223005845	ribonuclease P; Reviewed; Region: rnpA; PRK00499
488223005846	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
488223005847	propionate/acetate kinase; Provisional; Region: PRK12379
488223005848	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
488223005849	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223005850	S-adenosylmethionine binding site [chemical binding]; other site
488223005851	Methyltransferase domain; Region: Methyltransf_12; pfam08242
488223005852	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
488223005853	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
488223005854	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
488223005855	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
488223005856	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
488223005857	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
488223005858	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
488223005859	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
488223005860	Walker A motif; other site
488223005861	ATP binding site [chemical binding]; other site
488223005862	Walker B motif; other site
488223005863	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
488223005864	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
488223005865	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
488223005866	catalytic Zn binding site [ion binding]; other site
488223005867	structural Zn binding site [ion binding]; other site
488223005868	NAD(P) binding site [chemical binding]; other site
488223005869	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
488223005870	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
488223005871	active site
488223005872	dimer interface [polypeptide binding]; other site
488223005873	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
488223005874	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
488223005875	catalytic triad [active]
488223005876	catalytic triad [active]
488223005877	oxyanion hole [active]
488223005878	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
488223005879	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
488223005880	Predicted integral membrane protein [Function unknown]; Region: COG5523
488223005881	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
488223005882	putative substrate binding pocket [chemical binding]; other site
488223005883	AC domain interface; other site
488223005884	catalytic triad [active]
488223005885	AB domain interface; other site
488223005886	interchain disulfide; other site
488223005887	Predicted membrane protein [Function unknown]; Region: COG3759
488223005888	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
488223005889	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
488223005890	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223005891	motif II; other site
488223005892	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
488223005893	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
488223005894	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
488223005895	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
488223005896	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488223005897	catalytic residue [active]
488223005898	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
488223005899	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
488223005900	active site
488223005901	catalytic motif [active]
488223005902	Zn binding site [ion binding]; other site
488223005903	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
488223005904	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
488223005905	active site
488223005906	HIGH motif; other site
488223005907	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
488223005908	active site
488223005909	KMSKS motif; other site
488223005910	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
488223005911	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
488223005912	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
488223005913	active site
488223005914	dimer interface [polypeptide binding]; other site
488223005915	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
488223005916	dimer interface [polypeptide binding]; other site
488223005917	active site
488223005918	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
488223005919	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
488223005920	catalytic triad [active]
488223005921	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
488223005922	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488223005923	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223005924	Walker A/P-loop; other site
488223005925	ATP binding site [chemical binding]; other site
488223005926	Q-loop/lid; other site
488223005927	ABC transporter signature motif; other site
488223005928	Walker B; other site
488223005929	D-loop; other site
488223005930	H-loop/switch region; other site
488223005931	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
488223005932	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
488223005933	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
488223005934	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
488223005935	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223005936	Walker A/P-loop; other site
488223005937	ATP binding site [chemical binding]; other site
488223005938	Q-loop/lid; other site
488223005939	ABC transporter signature motif; other site
488223005940	Walker B; other site
488223005941	D-loop; other site
488223005942	H-loop/switch region; other site
488223005943	DNA mismatch repair protein MutS; Region: mutS1; TIGR01070
488223005944	MutS domain I; Region: MutS_I; pfam01624
488223005945	MutS domain II; Region: MutS_II; pfam05188
488223005946	MutS domain III; Region: MutS_III; pfam05192
488223005947	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
488223005948	Walker A/P-loop; other site
488223005949	ATP binding site [chemical binding]; other site
488223005950	Q-loop/lid; other site
488223005951	ABC transporter signature motif; other site
488223005952	Walker B; other site
488223005953	D-loop; other site
488223005954	H-loop/switch region; other site
488223005955	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
488223005956	arginine repressor; Region: argR_whole; TIGR01529
488223005957	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
488223005958	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
488223005959	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
488223005960	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
488223005961	active site
488223005962	HIGH motif; other site
488223005963	KMSK motif region; other site
488223005964	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
488223005965	tRNA binding surface [nucleotide binding]; other site
488223005966	anticodon binding site; other site
488223005967	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
488223005968	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
488223005969	Uncharacterized conserved protein [Function unknown]; Region: COG3542
488223005970	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
488223005971	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488223005972	active site
488223005973	phosphorylation site [posttranslational modification]
488223005974	intermolecular recognition site; other site
488223005975	dimerization interface [polypeptide binding]; other site
488223005976	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488223005977	DNA binding site [nucleotide binding]
488223005978	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
488223005979	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
488223005980	dimer interface [polypeptide binding]; other site
488223005981	phosphorylation site [posttranslational modification]
488223005982	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223005983	ATP binding site [chemical binding]; other site
488223005984	G-X-G motif; other site
488223005985	PBP superfamily domain; Region: PBP_like_2; cl17296
488223005986	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
488223005987	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
488223005988	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223005989	dimer interface [polypeptide binding]; other site
488223005990	conserved gate region; other site
488223005991	putative PBP binding loops; other site
488223005992	ABC-ATPase subunit interface; other site
488223005993	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
488223005994	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223005995	dimer interface [polypeptide binding]; other site
488223005996	conserved gate region; other site
488223005997	putative PBP binding loops; other site
488223005998	ABC-ATPase subunit interface; other site
488223005999	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
488223006000	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
488223006001	Walker A/P-loop; other site
488223006002	ATP binding site [chemical binding]; other site
488223006003	Q-loop/lid; other site
488223006004	ABC transporter signature motif; other site
488223006005	Walker B; other site
488223006006	D-loop; other site
488223006007	H-loop/switch region; other site
488223006008	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
488223006009	PhoU domain; Region: PhoU; pfam01895
488223006010	PhoU domain; Region: PhoU; pfam01895
488223006011	DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502
488223006012	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
488223006013	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
488223006014	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
488223006015	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
488223006016	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
488223006017	active site
488223006018	tetramer interface; other site
488223006019	Rhomboid family; Region: Rhomboid; pfam01694
488223006020	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
488223006021	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
488223006022	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
488223006023	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
488223006024	metal binding site [ion binding]; metal-binding site
488223006025	putative dimer interface [polypeptide binding]; other site
488223006026	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
488223006027	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
488223006028	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
488223006029	trimer interface [polypeptide binding]; other site
488223006030	active site
488223006031	substrate binding site [chemical binding]; other site
488223006032	CoA binding site [chemical binding]; other site
488223006033	EamA-like transporter family; Region: EamA; pfam00892
488223006034	Transglycosylase; Region: Transgly; pfam00912
488223006035	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
488223006036	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
488223006037	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
488223006038	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
488223006039	active site
488223006040	HIGH motif; other site
488223006041	dimer interface [polypeptide binding]; other site
488223006042	KMSKS motif; other site
488223006043	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
488223006044	RNA binding surface [nucleotide binding]; other site
488223006045	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
488223006046	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
488223006047	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
488223006048	motif II; other site
488223006049	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
488223006050	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
488223006051	S-adenosylmethionine binding site [chemical binding]; other site
488223006052	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
488223006053	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
488223006054	4-alpha-glucanotransferase; Provisional; Region: PRK14508
488223006055	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
488223006056	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
488223006057	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223006058	dimer interface [polypeptide binding]; other site
488223006059	conserved gate region; other site
488223006060	putative PBP binding loops; other site
488223006061	ABC-ATPase subunit interface; other site
488223006062	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
488223006063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
488223006064	dimer interface [polypeptide binding]; other site
488223006065	conserved gate region; other site
488223006066	putative PBP binding loops; other site
488223006067	ABC-ATPase subunit interface; other site
488223006068	Predicted integral membrane protein [Function unknown]; Region: COG5521
488223006069	Transcriptional regulators [Transcription]; Region: PurR; COG1609
488223006070	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
488223006071	DNA binding site [nucleotide binding]
488223006072	domain linker motif; other site
488223006073	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
488223006074	putative dimerization interface [polypeptide binding]; other site
488223006075	putative ligand binding site [chemical binding]; other site
488223006076	Uncharacterized conserved protein [Function unknown]; Region: COG1284
488223006077	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
488223006078	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
488223006079	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
488223006080	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
488223006081	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
488223006082	dimer interface [polypeptide binding]; other site
488223006083	anticodon binding site; other site
488223006084	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
488223006085	homodimer interface [polypeptide binding]; other site
488223006086	motif 1; other site
488223006087	active site
488223006088	motif 2; other site
488223006089	GAD domain; Region: GAD; pfam02938
488223006090	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
488223006091	motif 3; other site
488223006092	CAAX protease self-immunity; Region: Abi; pfam02517
488223006093	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
488223006094	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223006095	non-specific DNA binding site [nucleotide binding]; other site
488223006096	salt bridge; other site
488223006097	sequence-specific DNA binding site [nucleotide binding]; other site
488223006098	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
488223006099	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
488223006100	dimer interface [polypeptide binding]; other site
488223006101	motif 1; other site
488223006102	active site
488223006103	motif 2; other site
488223006104	motif 3; other site
488223006105	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
488223006106	anticodon binding site; other site
488223006107	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
488223006108	non-specific DNA binding site [nucleotide binding]; other site
488223006109	salt bridge; other site
488223006110	sequence-specific DNA binding site [nucleotide binding]; other site
488223006111	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
488223006112	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
488223006113	6-phosphogluconate dehydratase; Region: edd; TIGR01196
488223006114	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
488223006115	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
488223006116	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
488223006117	PYR/PP interface [polypeptide binding]; other site
488223006118	dimer interface [polypeptide binding]; other site
488223006119	TPP binding site [chemical binding]; other site
488223006120	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
488223006121	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
488223006122	TPP-binding site [chemical binding]; other site
488223006123	dimer interface [polypeptide binding]; other site
488223006124	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
488223006125	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
488223006126	active site
488223006127	P-loop; other site
488223006128	phosphorylation site [posttranslational modification]
488223006129	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
488223006130	PRD domain; Region: PRD; pfam00874
488223006131	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
488223006132	active site
488223006133	P-loop; other site
488223006134	phosphorylation site [posttranslational modification]
488223006135	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
488223006136	active site
488223006137	phosphorylation site [posttranslational modification]
488223006138	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
488223006139	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
488223006140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
488223006141	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
488223006142	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
488223006143	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
488223006144	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
488223006145	putative active site [active]
488223006146	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
488223006147	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
488223006148	nucleotide binding site [chemical binding]; other site
488223006149	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
488223006150	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
488223006151	active site
488223006152	metal binding site [ion binding]; metal-binding site
488223006153	homodimer interface [polypeptide binding]; other site
488223006154	catalytic site [active]
488223006155	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
488223006156	Uncharacterized conserved protein [Function unknown]; Region: COG3538
488223006157	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
488223006158	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
488223006159	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
488223006160	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
488223006161	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
488223006162	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
488223006163	arginine deiminase; Provisional; Region: PRK01388
488223006164	ornithine carbamoyltransferase; Validated; Region: PRK02102
488223006165	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
488223006166	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
488223006167	carbamate kinase; Reviewed; Region: PRK12686
488223006168	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
488223006169	putative substrate binding site [chemical binding]; other site
488223006170	nucleotide binding site [chemical binding]; other site
488223006171	nucleotide binding site [chemical binding]; other site
488223006172	homodimer interface [polypeptide binding]; other site
488223006173	Predicted membrane protein [Function unknown]; Region: COG1288
488223006174	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
488223006175	hypothetical protein; Provisional; Region: PRK07205
488223006176	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
488223006177	active site
488223006178	metal binding site [ion binding]; metal-binding site
488223006179	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
488223006180	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
488223006181	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
488223006182	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
488223006183	dimer interface [polypeptide binding]; other site
488223006184	active site
488223006185	metal binding site [ion binding]; metal-binding site
488223006186	L-fucose isomerase; Provisional; Region: fucI; PRK10991
488223006187	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
488223006188	hexamer (dimer of trimers) interface [polypeptide binding]; other site
488223006189	trimer interface [polypeptide binding]; other site
488223006190	substrate binding site [chemical binding]; other site
488223006191	Mn binding site [ion binding]; other site
488223006192	Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306
488223006193	Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307
488223006194	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
488223006195	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
488223006196	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
488223006197	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
488223006198	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
488223006199	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
488223006200	active site
488223006201	phosphorylation site [posttranslational modification]
488223006202	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
488223006203	active pocket/dimerization site; other site
488223006204	active site
488223006205	phosphorylation site [posttranslational modification]
488223006206	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
488223006207	L-fuculose phosphate aldolase; Provisional; Region: PRK06833
488223006208	intersubunit interface [polypeptide binding]; other site
488223006209	active site
488223006210	Zn2+ binding site [ion binding]; other site
488223006211	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
488223006212	N- and C-terminal domain interface [polypeptide binding]; other site
488223006213	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
488223006214	active site
488223006215	putative catalytic site [active]
488223006216	metal binding site [ion binding]; metal-binding site
488223006217	ATP binding site [chemical binding]; other site
488223006218	carbohydrate binding site [chemical binding]; other site
488223006219	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
488223006220	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
488223006221	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
488223006222	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
488223006223	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
488223006224	metal binding site [ion binding]; metal-binding site
488223006225	YodA lipocalin-like domain; Region: YodA; pfam09223
488223006226	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
488223006227	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
488223006228	ABC-ATPase subunit  interface; other site
488223006229	dimer interface [polypeptide binding]; other site
488223006230	putative PBP binding regions; other site
488223006231	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
488223006232	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
488223006233	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
488223006234	putative DNA binding site [nucleotide binding]; other site
488223006235	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
488223006236	DltD N-terminal region; Region: DltD_N; pfam04915
488223006237	DltD central region; Region: DltD_M; pfam04918
488223006238	DltD C-terminal region; Region: DltD_C; pfam04914
488223006239	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
488223006240	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
488223006241	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
488223006242	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
488223006243	acyl-activating enzyme (AAE) consensus motif; other site
488223006244	AMP binding site [chemical binding]; other site
488223006245	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
488223006246	H+ Antiporter protein; Region: 2A0121; TIGR00900
488223006247	putative substrate translocation pore; other site
488223006248	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
488223006249	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
488223006250	putative active site [active]
488223006251	putative NTP binding site [chemical binding]; other site
488223006252	putative nucleic acid binding site [nucleotide binding]; other site
488223006253	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
488223006254	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
488223006255	amphipathic channel; other site
488223006256	Asn-Pro-Ala signature motifs; other site
488223006257	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
488223006258	glycerol kinase; Provisional; Region: glpK; PRK00047
488223006259	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
488223006260	N- and C-terminal domain interface [polypeptide binding]; other site
488223006261	active site
488223006262	MgATP binding site [chemical binding]; other site
488223006263	catalytic site [active]
488223006264	metal binding site [ion binding]; metal-binding site
488223006265	glycerol binding site [chemical binding]; other site
488223006266	homotetramer interface [polypeptide binding]; other site
488223006267	homodimer interface [polypeptide binding]; other site
488223006268	FBP binding site [chemical binding]; other site
488223006269	protein IIAGlc interface [polypeptide binding]; other site
488223006270	Mga helix-turn-helix domain; Region: Mga; pfam05043
488223006271	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
488223006272	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
488223006273	dimerization interface [polypeptide binding]; other site
488223006274	domain crossover interface; other site
488223006275	redox-dependent activation switch; other site
488223006276	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
488223006277	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
488223006278	FMN binding site [chemical binding]; other site
488223006279	active site
488223006280	catalytic residues [active]
488223006281	substrate binding site [chemical binding]; other site
488223006282	RICH domain; Region: RICH; pfam05062
488223006283	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223006284	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
488223006285	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223006286	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223006287	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223006288	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
488223006289	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223006290	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
488223006291	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
488223006292	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
488223006293	dimerization interface [polypeptide binding]; other site
488223006294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
488223006295	dimer interface [polypeptide binding]; other site
488223006296	phosphorylation site [posttranslational modification]
488223006297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
488223006298	ATP binding site [chemical binding]; other site
488223006299	Mg2+ binding site [ion binding]; other site
488223006300	G-X-G motif; other site
488223006301	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
488223006302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488223006303	active site
488223006304	phosphorylation site [posttranslational modification]
488223006305	intermolecular recognition site; other site
488223006306	dimerization interface [polypeptide binding]; other site
488223006307	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
488223006308	DNA binding site [nucleotide binding]
488223006309	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
488223006310	Clp amino terminal domain; Region: Clp_N; pfam02861
488223006311	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223006312	Walker A motif; other site
488223006313	ATP binding site [chemical binding]; other site
488223006314	Walker B motif; other site
488223006315	arginine finger; other site
488223006316	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
488223006317	Walker A motif; other site
488223006318	ATP binding site [chemical binding]; other site
488223006319	Walker B motif; other site
488223006320	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
488223006321	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
488223006322	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
488223006323	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
488223006324	Walker A/P-loop; other site
488223006325	ATP binding site [chemical binding]; other site
488223006326	Q-loop/lid; other site
488223006327	ABC transporter signature motif; other site
488223006328	Walker B; other site
488223006329	D-loop; other site
488223006330	H-loop/switch region; other site
488223006331	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
488223006332	NMT1/THI5 like; Region: NMT1; pfam09084
488223006333	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
488223006334	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
488223006335	putative PBP binding loops; other site
488223006336	ABC-ATPase subunit interface; other site
488223006337	Uncharacterized conserved protein [Function unknown]; Region: COG0011
488223006338	Surface antigen [General function prediction only]; Region: COG3942
488223006339	CHAP domain; Region: CHAP; pfam05257
488223006340	Bacterial SH3 domain; Region: SH3_5; pfam08460
488223006341	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
488223006342	Bacterial SH3 domain; Region: SH3_5; pfam08460
488223006343	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
488223006344	Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466
488223006345	replicative DNA helicase; Provisional; Region: PRK05748
488223006346	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
488223006347	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
488223006348	Walker A motif; other site
488223006349	ATP binding site [chemical binding]; other site
488223006350	Walker B motif; other site
488223006351	DNA binding loops [nucleotide binding]
488223006352	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
488223006353	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
488223006354	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
488223006355	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
488223006356	DHH family; Region: DHH; pfam01368
488223006357	DHHA1 domain; Region: DHHA1; pfam02272
488223006358	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
488223006359	30S subunit binding site; other site
488223006360	comF family protein; Region: comF; TIGR00201
488223006361	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
488223006362	active site
488223006363	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
488223006364	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
488223006365	ATP binding site [chemical binding]; other site
488223006366	putative Mg++ binding site [ion binding]; other site
488223006367	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
488223006368	nucleotide binding region [chemical binding]; other site
488223006369	ATP-binding site [chemical binding]; other site
488223006370	Uncharacterized conserved protein [Function unknown]; Region: COG1739
488223006371	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
488223006372	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
488223006373	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
488223006374	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
488223006375	dimer interface [polypeptide binding]; other site
488223006376	pyridoxal 5'-phosphate binding site [chemical binding]; other site
488223006377	catalytic residue [active]
488223006378	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
488223006379	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
488223006380	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
488223006381	elongation factor Ts; Provisional; Region: tsf; PRK09377
488223006382	UBA/TS-N domain; Region: UBA; pfam00627
488223006383	Elongation factor TS; Region: EF_TS; pfam00889
488223006384	Elongation factor TS; Region: EF_TS; pfam00889
488223006385	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
488223006386	rRNA interaction site [nucleotide binding]; other site
488223006387	S8 interaction site; other site
488223006388	putative laminin-1 binding site; other site
488223006389	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
488223006390	Septum formation initiator; Region: DivIC; cl17659
488223006391	Surface antigen [General function prediction only]; Region: COG3942
488223006392	CHAP domain; Region: CHAP; pfam05257
488223006393	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
488223006394	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
488223006395	rod shape-determining protein MreC; Region: MreC; pfam04085
488223006396	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
488223006397	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
488223006398	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
488223006399	Walker A/P-loop; other site
488223006400	ATP binding site [chemical binding]; other site
488223006401	Q-loop/lid; other site
488223006402	ABC transporter signature motif; other site
488223006403	Walker B; other site
488223006404	D-loop; other site
488223006405	H-loop/switch region; other site
488223006406	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
488223006407	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
488223006408	Walker A/P-loop; other site
488223006409	ATP binding site [chemical binding]; other site
488223006410	Q-loop/lid; other site
488223006411	ABC transporter signature motif; other site
488223006412	Walker B; other site
488223006413	D-loop; other site
488223006414	H-loop/switch region; other site
488223006415	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
488223006416	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
488223006417	Helix-turn-helix domain; Region: HTH_25; pfam13413
488223006418	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
488223006419	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
488223006420	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
488223006421	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
488223006422	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
488223006423	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
488223006424	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
488223006425	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
488223006426	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
488223006427	Walker A/P-loop; other site
488223006428	ATP binding site [chemical binding]; other site
488223006429	Q-loop/lid; other site
488223006430	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
488223006431	ABC transporter signature motif; other site
488223006432	Walker B; other site
488223006433	D-loop; other site
488223006434	H-loop/switch region; other site
488223006435	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
488223006436	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
488223006437	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
488223006438	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
488223006439	active site
488223006440	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
488223006441	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
488223006442	active site
488223006443	HIGH motif; other site
488223006444	dimer interface [polypeptide binding]; other site
488223006445	KMSKS motif; other site
488223006446	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
488223006447	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488223006448	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488223006449	ABC transporter; Region: ABC_tran_2; pfam12848
488223006450	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
488223006451	Predicted membrane protein [Function unknown]; Region: COG4485
488223006452	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
488223006453	Predicted membrane protein [Function unknown]; Region: COG1511
488223006454	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
488223006455	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
488223006456	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
488223006457	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
488223006458	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
488223006459	active site
488223006460	phosphorylation site [posttranslational modification]
488223006461	intermolecular recognition site; other site
488223006462	dimerization interface [polypeptide binding]; other site
488223006463	LytTr DNA-binding domain; Region: LytTR; pfam04397
488223006464	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
488223006465	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
488223006466	COMC family; Region: ComC; pfam03047
488223006467	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
488223006468	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
488223006469	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
488223006470	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
488223006471	protein binding site [polypeptide binding]; other site
488223006472	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
488223006473	ParB-like nuclease domain; Region: ParBc; pfam02195
488223006474	KorB domain; Region: KorB; pfam08535