-- dump date 20140620_084929 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type NP_357595.1 15902045 932985 1..1362 1 NC_003098.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1362 dnaA 932985 dnaA Streptococcus pneumoniae R6 chromosomal replication initiation protein NP_357595.1 1 D 171101 CDS NP_357596.1 15902046 933376 1521..2657 1 NC_003098.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2657 dnaN 933376 dnaN Streptococcus pneumoniae R6 DNA polymerase III subunit beta NP_357596.1 1521 D 171101 CDS NP_357597.1 15902047 932878 2722..2916 1 NC_003098.1 hypothetical protein 2916 932878 spr0003 Streptococcus pneumoniae R6 hypothetical protein NP_357597.1 2722 D 171101 CDS NP_357598.1 15902048 933428 3000..4115 1 NC_003098.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 4115 933428 spr0004 Streptococcus pneumoniae R6 GTP-dependent nucleic acid-binding protein EngD NP_357598.1 3000 D 171101 CDS NP_357599.1 15902049 933315 4186..4755 1 NC_003098.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4755 pth 933315 pth Streptococcus pneumoniae R6 peptidyl-tRNA hydrolase NP_357599.1 4186 D 171101 CDS NP_357600.1 15902050 933199 4756..8265 1 NC_003098.1 transcription-repair coupling factor 8265 mfd 933199 mfd Streptococcus pneumoniae R6 transcription-repair coupling factor NP_357600.1 4756 D 171101 CDS NP_357601.1 15902051 933324 8323..8589 1 NC_003098.1 S4 domain-containing protein 8589 933324 spr0007 Streptococcus pneumoniae R6 S4 domain-containing protein NP_357601.1 8323 D 171101 CDS NP_357602.1 15902052 933400 8582..8950 1 NC_003098.1 hypothetical protein 8950 933400 spr0008 Streptococcus pneumoniae R6 hypothetical protein NP_357602.1 8582 D 171101 CDS NP_357603.1 15902053 933406 9001..10338 1 NC_003098.1 hypothetical protein 10338 933406 spr0009 Streptococcus pneumoniae R6 hypothetical protein NP_357603.1 9001 D 171101 CDS NP_357604.1 15902054 933448 10335..11612 1 NC_003098.1 cell cycle protein of the MesJ/Ycf62 family; hypothetical protein 11612 933448 spr0010 Streptococcus pneumoniae R6 hypothetical protein NP_357604.1 10335 D 171101 CDS NP_357605.1 15902055 933767 11616..12158 1 NC_003098.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 12158 hgt 933767 hgt Streptococcus pneumoniae R6 hypoxanthine-guanine phosphoribosyltransferase NP_357605.1 11616 D 171101 CDS NP_357606.1 15902056 933698 12174..14132 1 NC_003098.1 cell division protein FtsH 14132 ftsH 933698 ftsH Streptococcus pneumoniae R6 cell division protein FtsH NP_357606.1 12174 D 171101 CDS NP_357607.1 15902057 933686 14254..14733 1 NC_003098.1 sigma factor; competence-specific global transcription modulator 14733 comX1 933686 comX1 Streptococcus pneumoniae R6 competence-specific global transcription modulator NP_357607.1 14254 D 171101 CDS NP_357608.1 15902058 933716 20207..20554 1 NC_003098.1 transposase 20554 transposase_A 933716 transposase_A Streptococcus pneumoniae R6 transposase NP_357608.1 20207 D 171101 CDS NP_357610.1 15902060 932809 20733..21071 1 NC_003098.1 transposase 21071 transposase_B 932809 transposase_B Streptococcus pneumoniae R6 transposase NP_357610.1 20733 D 171101 CDS NP_357614.1 15902064 932833 22162..22404 1 NC_003098.1 hypothetical protein 22404 932833 spr0020 Streptococcus pneumoniae R6 hypothetical protein NP_357614.1 22162 D 171101 CDS NP_357615.1 15902065 933413 22635..23921 1 NC_003098.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 23921 purA 933413 purA Streptococcus pneumoniae R6 adenylosuccinate synthetase NP_357615.1 22635 D 171101 CDS NP_357616.1 15902066 933408 24122..24589 1 NC_003098.1 cytidine/deoxycytidylate deaminase 24589 933408 spr0022 Streptococcus pneumoniae R6 cytidine/deoxycytidylate deaminase NP_357616.1 24122 D 171101 CDS NP_357617.1 15902067 933917 24776..25219 1 NC_003098.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 25219 dut 933917 dut Streptococcus pneumoniae R6 deoxyuridine 5'-triphosphate nucleotidohydrolase NP_357617.1 24776 D 171101 CDS NP_357618.1 15902068 933009 25158..25736 1 NC_003098.1 Similar to phosphoglycerate mutase; hypothetical protein 25736 933009 spr0024 Streptococcus pneumoniae R6 hypothetical protein NP_357618.1 25158 D 171101 CDS NP_357619.1 15902069 933443 25849..27111 1 NC_003098.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 27111 radA 933443 radA Streptococcus pneumoniae R6 DNA repair protein RadA NP_357619.1 25849 D 171101 CDS NP_357620.1 15902070 933190 27115..27681 1 NC_003098.1 hypothetical protein 27681 933190 spr0026 Streptococcus pneumoniae R6 hypothetical protein NP_357620.1 27115 D 171101 CDS NP_357621.1 15902071 933470 27706..28365 1 NC_003098.1 hypothetical protein 28365 933470 spr0027 Streptococcus pneumoniae R6 hypothetical protein NP_357621.1 27706 D 171101 CDS NP_357622.1 15902072 932853 28583..29602 1 NC_003098.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 29602 prsA 932853 prsA Streptococcus pneumoniae R6 ribose-phosphate pyrophosphokinase NP_357622.1 28583 D 171101 CDS NP_357624.1 15902074 933421 complement(30143..30481) 1 NC_003098.1 hypothetical protein 30481 933421 spr0030 Streptococcus pneumoniae R6 hypothetical protein NP_357624.1 30143 R 171101 CDS NP_357625.1 15902075 933179 complement(30700..31053) 1 NC_003098.1 hypothetical protein 31053 933179 spr0031 Streptococcus pneumoniae R6 hypothetical protein NP_357625.1 30700 R 171101 CDS NP_357626.1 15902076 933214 31306..33939 1 NC_003098.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 33939 polA 933214 polA Streptococcus pneumoniae R6 DNA polymerase I NP_357626.1 31306 D 171101 CDS NP_357627.1 15902077 933816 34024..34461 1 NC_003098.1 hypothetical protein 34461 933816 spr0033 Streptococcus pneumoniae R6 hypothetical protein NP_357627.1 34024 D 171101 CDS NP_357628.1 15902078 933827 complement(34652..35674) 1 NC_003098.1 hypothetical protein 35674 933827 spr0034 Streptococcus pneumoniae R6 hypothetical protein NP_357628.1 34652 R 171101 CDS NP_357629.1 15902079 932812 35811..36980 1 NC_003098.1 catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 36980 aspC 932812 aspC Streptococcus pneumoniae R6 aromatic amino acid aminotransferase NP_357629.1 35811 D 171101 CDS NP_357630.1 15902080 933442 36977..37747 1 NC_003098.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 37747 recO 933442 recO Streptococcus pneumoniae R6 DNA repair protein RecO NP_357630.1 36977 D 171101 CDS NP_357631.1 15902081 932937 37744..38736 1 NC_003098.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 38736 plsX 932937 plsX Streptococcus pneumoniae R6 glycerol-3-phosphate acyltransferase PlsX NP_357631.1 37744 D 171101 CDS NP_357632.1 15902082 933946 38742..38975 1 NC_003098.1 acyl carrier protein 38975 acpP 933946 acpP Streptococcus pneumoniae R6 acyl carrier protein NP_357632.1 38742 D 171101 CDS NP_357634.1 15902084 932910 39514..39744 1 NC_003098.1 amphipathic pore-forming protein 39744 thmA 932910 thmA Streptococcus pneumoniae R6 amphipathic pore-forming protein NP_357634.1 39514 D 171101 CDS NP_357635.1 15902085 933120 complement(40224..40991) 1 NC_003098.1 transposase 40991 IS1167 933120 IS1167 Streptococcus pneumoniae R6 transposase NP_357635.1 40224 R 171101 CDS NP_357636.1 15902086 933460 complement(40982..41500) 1 NC_003098.1 transposase 41500 IS1167 933460 IS1167 Streptococcus pneumoniae R6 transposase NP_357636.1 40982 R 171101 CDS NP_357637.1 15902087 933354 41902..44055 1 NC_003098.1 Competence induced protein ComA, with ComB is responsible for secretion of CSP; competence factor transporting ATP-binding protein/permease ComA 44055 comA 933354 comA Streptococcus pneumoniae R6 competence factor transporting ATP-binding protein/permease ComA NP_357637.1 41902 D 171101 CDS NP_357638.1 15902088 933217 44068..45417 1 NC_003098.1 Competence induced protein ComB, with ComA is responsible for secretion of CSP; competence factor transport protein ComB 45417 comB 933217 comB Streptococcus pneumoniae R6 competence factor transport protein ComB NP_357638.1 44068 D 171101 CDS NP_357639.1 15902089 933370 45545..46294 1 NC_003098.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 46294 purC 933370 purC Streptococcus pneumoniae R6 phosphoribosylaminoimidazole-succinocarboxamide synthase NP_357639.1 45545 D 171101 CDS NP_357640.1 15902090 933136 46493..50221 1 NC_003098.1 phosphoribosylformylglycinamidine synthase 50221 purL 933136 purL Streptococcus pneumoniae R6 phosphoribosylformylglycinamidine synthase NP_357640.1 46493 D 171101 CDS NP_357641.1 15902091 933435 50314..51756 1 NC_003098.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 51756 purF 933435 purF Streptococcus pneumoniae R6 amidophosphoribosyltransferase NP_357641.1 50314 D 171101 CDS NP_357642.1 15902092 933451 51793..52815 1 NC_003098.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 52815 purM 933451 purM Streptococcus pneumoniae R6 phosphoribosylaminoimidazole synthetase NP_357642.1 51793 D 171101 CDS NP_357643.1 15902093 933927 52812..53357 1 NC_003098.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 53357 purN 933927 purN Streptococcus pneumoniae R6 phosphoribosylglycinamide formyltransferase NP_357643.1 52812 D 171101 CDS NP_357644.1 15902094 933039 53441..53950 1 NC_003098.1 VanZ protein 53950 vanZ 933039 vanZ Streptococcus pneumoniae R6 VanZ protein NP_357644.1 53441 D 171101 CDS NP_357645.1 15902095 933467 53954..55522 1 NC_003098.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 55522 purH 933467 purH Streptococcus pneumoniae R6 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase NP_357645.1 53954 D 171101 CDS NP_357646.1 15902096 933188 55644..56906 1 NC_003098.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 56906 purD 933188 purD Streptococcus pneumoniae R6 phosphoribosylamine--glycine ligase NP_357646.1 55644 D 171101 CDS YP_008719798.1 555247344 17374503 56979..57146 1 NC_003098.1 hypothetical protein 57146 17374503 spr0052a Streptococcus pneumoniae R6 hypothetical protein YP_008719798.1 56979 D 171101 CDS NP_357647.1 15902097 933469 57276..57797 1 NC_003098.1 Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit 57797 purE 933469 purE Streptococcus pneumoniae R6 phosphoribosylaminoimidazole carboxylase catalytic subunit NP_357647.1 57276 D 171101 CDS NP_357648.1 15902098 933386 57724..58875 1 NC_003098.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 58875 purK 933386 purK Streptococcus pneumoniae R6 phosphoribosylaminoimidazole carboxylase ATPase subunit NP_357648.1 57724 D 171101 CDS NP_357649.1 15902099 933457 58885..59112 1 NC_003098.1 hypothetical protein 59112 933457 spr0055 Streptococcus pneumoniae R6 hypothetical protein NP_357649.1 58885 D 171101 CDS NP_357650.1 15902100 933426 59175..60473 1 NC_003098.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 60473 purB 933426 purB Streptococcus pneumoniae R6 adenylosuccinate lyase NP_357650.1 59175 D 171101 CDS NP_357651.1 15902101 933411 complement(60528..64466) 1 NC_003098.1 beta-N-acetylhexosaminidase 64466 strH 933411 strH Streptococcus pneumoniae R6 beta-N-acetylhexosaminidase NP_357651.1 60528 R 171101 CDS NP_357652.1 15902102 933173 complement(64781..65539) 1 NC_003098.1 Similar to transcriptional regulator (GntR family); hypothetical protein 65539 933173 spr0058 Streptococcus pneumoniae R6 hypothetical protein NP_357652.1 64781 R 171101 CDS NP_357653.1 15902103 934033 65845..67632 1 NC_003098.1 beta-galactosidase 3 67632 bgaC 934033 bgaC Streptococcus pneumoniae R6 beta-galactosidase 3 NP_357653.1 65845 D 171101 CDS NP_357654.1 15902104 933462 67629..68105 1 NC_003098.1 PTS system transporter subunit IIB 68105 PTS-EIIB 933462 PTS-EIIB Streptococcus pneumoniae R6 PTS system transporter subunit IIB NP_357654.1 67629 D 171101 CDS NP_357655.1 15902105 933468 68133..69038 1 NC_003098.1 PTS system transporter subunit IIC 69038 PTS-EIIC 933468 PTS-EIIC Streptococcus pneumoniae R6 PTS system transporter subunit IIC NP_357655.1 68133 D 171101 CDS NP_357656.1 15902106 933330 69010..69840 1 NC_003098.1 PTS system transporter subunit IID 69840 PTS-EIID 933330 PTS-EIID Streptococcus pneumoniae R6 PTS system transporter subunit IID NP_357656.1 69010 D 171101 CDS NP_357657.1 15902107 932847 69847..70251 1 NC_003098.1 PTS system transporter subunit IIA 70251 PTS-EII 932847 PTS-EII Streptococcus pneumoniae R6 PTS system transporter subunit IIA NP_357657.1 69847 D 171101 CDS NP_357658.1 15902108 932790 70549..71715 1 NC_003098.1 sugar isomerase domain-containing protein 71715 agaS 932790 agaS Streptococcus pneumoniae R6 sugar isomerase domain-containing protein NP_357658.1 70549 D 171101 CDS NP_357659.1 15902109 932955 71831..72868 1 NC_003098.1 aldose 1-epimerase 72868 galM 932955 galM Streptococcus pneumoniae R6 aldose 1-epimerase NP_357659.1 71831 D 171101 CDS NP_357660.1 15902110 932795 73075..73929 1 NC_003098.1 hypothetical protein 73929 932795 spr0066 Streptococcus pneumoniae R6 hypothetical protein NP_357660.1 73075 D 171101 CDS NP_357661.1 15902111 932792 74079..74336 1 NC_003098.1 hypothetical protein 74336 932792 spr0067 Streptococcus pneumoniae R6 hypothetical protein NP_357661.1 74079 D 171101 CDS NP_357662.1 15902112 932794 75311..76075 1 NC_003098.1 Similar to uridine phosphorylase; hypothetical protein 76075 932794 spr0068 Streptococcus pneumoniae R6 hypothetical protein NP_357662.1 75311 D 171101 CDS NP_357663.1 15902113 934052 76547..76705 1 NC_003098.1 hypothetical protein 76705 934052 spr0069 Streptococcus pneumoniae R6 hypothetical protein NP_357663.1 76547 D 171101 CDS NP_357664.1 15902114 932801 76686..78065 1 NC_003098.1 Trk transporter membrane-spanning protein 78065 trkH 932801 trkH Streptococcus pneumoniae R6 Trk transporter membrane-spanning protein NP_357664.1 76686 D 171101 CDS NP_357665.1 15902115 932799 78058..78744 1 NC_003098.1 Trk transporter NAD+ binding protein 78744 trkA 932799 trkA Streptococcus pneumoniae R6 Trk transporter NAD+ binding protein NP_357665.1 78058 D 171101 CDS NP_357669.1 15902119 932818 80186..83671 1 NC_003098.1 Similar to cell wall-associated serine proteinase; cell wall surface anchor family protein 83671 932818 spr0075 Streptococcus pneumoniae R6 cell wall surface anchor family protein NP_357669.1 80186 D 171101 CDS NP_357670.1 15902120 932813 83838..84536 1 NC_003098.1 DNA-binding response regulator 84536 rr08 932813 rr08 Streptococcus pneumoniae R6 DNA-binding response regulator NP_357670.1 83838 D 171101 CDS NP_357671.1 15902121 932804 84533..85585 1 NC_003098.1 sensor histidine kinase 85585 hk08 932804 hk08 Streptococcus pneumoniae R6 sensor histidine kinase NP_357671.1 84533 D 171101 CDS NP_357672.1 15902122 932816 85780..86391 1 NC_003098.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 86391 rpsD 932816 rpsD Streptococcus pneumoniae R6 30S ribosomal protein S4 NP_357672.1 85780 D 171101 CDS NP_357673.1 15902123 932823 86559..86735 1 NC_003098.1 degenerative transposase 86735 transposase_A 932823 transposase_A Streptococcus pneumoniae R6 degenerative transposase NP_357673.1 86559 D 171101 CDS NP_357674.1 15902124 932834 87044..87313 1 NC_003098.1 hypothetical protein 87313 932834 spr0080 Streptococcus pneumoniae R6 hypothetical protein NP_357674.1 87044 D 171101 CDS NP_357675.1 15902125 932828 87777..88736 1 NC_003098.1 ABC transporter permease 88736 ABC-MSP 932828 ABC-MSP Streptococcus pneumoniae R6 ABC transporter permease NP_357675.1 87777 D 171101 CDS NP_357676.1 15902126 932824 88750..89673 1 NC_003098.1 ABC transporter permease 89673 ABC-MSP 932824 ABC-MSP Streptococcus pneumoniae R6 ABC transporter permease NP_357676.1 88750 D 171101 CDS NP_357677.1 15902127 932838 89862..91406 1 NC_003098.1 ABC transporter substrate-binding protein 91406 ABC-SBP 932838 ABC-SBP Streptococcus pneumoniae R6 ABC transporter substrate-binding protein NP_357677.1 89862 D 171101 CDS NP_357678.1 15902128 932820 91678..92664 1 NC_003098.1 hypothetical protein 92664 932820 spr0084 Streptococcus pneumoniae R6 hypothetical protein NP_357678.1 91678 D 171101 CDS NP_357679.1 15902129 932845 92633..93646 1 NC_003098.1 hypothetical protein 93646 932845 spr0085 Streptococcus pneumoniae R6 hypothetical protein NP_357679.1 92633 D 171101 CDS NP_357680.1 15902130 932843 complement(93718..94782) 1 NC_003098.1 hypothetical protein 94782 932843 spr0086 Streptococcus pneumoniae R6 hypothetical protein NP_357680.1 93718 R 171101 CDS NP_357681.1 15902131 932839 complement(94845..95807) 1 NC_003098.1 hypothetical protein 95807 932839 spr0087 Streptococcus pneumoniae R6 hypothetical protein NP_357681.1 94845 R 171101 CDS NP_357682.1 15902132 932844 complement(95749..96342) 1 NC_003098.1 hypothetical protein 96342 932844 spr0088 Streptococcus pneumoniae R6 hypothetical protein NP_357682.1 95749 R 171101 CDS NP_357683.1 15902133 932854 complement(96329..96655) 1 NC_003098.1 hypothetical protein 96655 932854 spr0089 Streptococcus pneumoniae R6 hypothetical protein NP_357683.1 96329 R 171101 CDS NP_357684.1 15902134 932858 complement(96794..97960) 1 NC_003098.1 transporter 97960 932858 spr0090 Streptococcus pneumoniae R6 transporter NP_357684.1 96794 R 171101 CDS NP_357685.1 15902135 932836 98018..99175 1 NC_003098.1 sugar transferase related protein; hypothetical protein 99175 932836 spr0091 Streptococcus pneumoniae R6 hypothetical protein NP_357685.1 98018 D 171101 CDS NP_357686.1 15902136 932856 99217..101067 1 NC_003098.1 capsule polysaccharide biosynthesis protein CapD 101067 capD 932856 capD Streptococcus pneumoniae R6 capsule polysaccharide biosynthesis protein CapD NP_357686.1 99217 D 171101 CDS NP_357687.1 15902137 932857 complement(101463..102095) 1 NC_003098.1 phosphoglycolate phosphatase 102095 gph 932857 gph Streptococcus pneumoniae R6 phosphoglycolate phosphatase NP_357687.1 101463 R 171101 CDS NP_357688.1 15902138 932859 complement(102117..102989) 1 NC_003098.1 L-serine dehydratase subunit alpha 102989 sdaA 932859 sdaA Streptococcus pneumoniae R6 L-serine dehydratase subunit alpha NP_357688.1 102117 R 171101 CDS NP_357689.1 15902139 932851 complement(102998..103669) 1 NC_003098.1 L-serine dehydratase subunit beta 103669 sdaB 932851 sdaB Streptococcus pneumoniae R6 L-serine dehydratase subunit beta NP_357689.1 102998 R 171101 CDS NP_357690.1 15902140 932867 103911..104414 1 NC_003098.1 LysM domain-containing protein 104414 932867 spr0096 Streptococcus pneumoniae R6 LysM domain-containing protein NP_357690.1 103911 D 171101 CDS NP_357692.1 15902142 932864 105242..105490 1 NC_003098.1 bacteriocin 105490 932864 spr0098 Streptococcus pneumoniae R6 bacteriocin NP_357692.1 105242 D 171101 CDS NP_357693.1 15902143 932866 105545..107653 1 NC_003098.1 amino acid ABC transporter permease 107653 ABC-MSP 932866 ABC-MSP Streptococcus pneumoniae R6 amino acid ABC transporter permease NP_357693.1 105545 D 171101 CDS NP_357694.1 15902144 932876 107650..108291 1 NC_003098.1 amino acid ABC transporter ATP-binding protein 108291 ABC-NBD 932876 ABC-NBD Streptococcus pneumoniae R6 amino acid ABC transporter ATP-binding protein NP_357694.1 107650 D 171101 CDS NP_357695.1 15902145 932861 108506..109303 1 NC_003098.1 amino acid ABC transporter substrate-binding protein 109303 ABC-SBP 932861 ABC-SBP Streptococcus pneumoniae R6 amino acid ABC transporter substrate-binding protein NP_357695.1 108506 D 171101 CDS NP_357696.1 15902146 932865 109269..110516 1 NC_003098.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 110516 argG 932865 argG Streptococcus pneumoniae R6 argininosuccinate synthase NP_357696.1 109269 D 171101 CDS NP_357697.1 15902147 932888 110545..111936 1 NC_003098.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 111936 argH 932888 argH Streptococcus pneumoniae R6 argininosuccinate lyase NP_357697.1 110545 D 171101 CDS NP_357698.1 15902148 932874 complement(112225..113124) 1 NC_003098.1 hypothetical protein 113124 932874 spr0104 Streptococcus pneumoniae R6 hypothetical protein NP_357698.1 112225 R 171101 CDS NP_357700.1 15902150 932887 113839..115773 1 NC_003098.1 Similar to competence factor transporting ATP-binding/permease ComA; ABC transporter permease/ATP-binding protein 115773 932887 spr0106 Streptococcus pneumoniae R6 ABC transporter permease/ATP-binding protein NP_357700.1 113839 D 171101 CDS NP_357701.1 15902151 932869 115766..116233 1 NC_003098.1 hypothetical protein 116233 932869 spr0107 Streptococcus pneumoniae R6 hypothetical protein NP_357701.1 115766 D 171101 CDS NP_357702.1 15902152 932889 116230..117582 1 NC_003098.1 Similar to ComB protein; hypothetical protein 117582 932889 spr0108 Streptococcus pneumoniae R6 hypothetical protein NP_357702.1 116230 D 171101 CDS NP_357703.1 15902153 932896 117728..118108 1 NC_003098.1 hypothetical protein 118108 932896 spr0109 Streptococcus pneumoniae R6 hypothetical protein NP_357703.1 117728 D 171101 CDS NP_357704.1 15902154 932885 complement(118611..118931) 1 NC_003098.1 hypothetical protein 118931 932885 spr0110 Streptococcus pneumoniae R6 hypothetical protein NP_357704.1 118611 R 171101 CDS NP_357705.1 15902155 932883 119688..120059 1 NC_003098.1 hypothetical protein 120059 932883 spr0111 Streptococcus pneumoniae R6 hypothetical protein NP_357705.1 119688 D 171101 CDS NP_357706.1 15902156 932895 120067..120279 1 NC_003098.1 hypothetical protein 120279 932895 spr0112 Streptococcus pneumoniae R6 hypothetical protein NP_357706.1 120067 D 171101 CDS NP_357707.1 15902157 932879 121084..122142 1 NC_003098.1 hypothetical protein 122142 932879 spr0113 Streptococcus pneumoniae R6 hypothetical protein NP_357707.1 121084 D 171101 CDS NP_357708.1 15902158 932880 122441..123433 1 NC_003098.1 hypothetical protein 123433 932880 spr0114 Streptococcus pneumoniae R6 hypothetical protein NP_357708.1 122441 D 171101 CDS NP_357709.1 15902159 932891 123810..124184 1 NC_003098.1 hypothetical protein 124184 932891 spr0115 Streptococcus pneumoniae R6 hypothetical protein NP_357709.1 123810 D 171101 CDS NP_357710.1 15902160 932892 124191..124373 1 NC_003098.1 hypothetical protein 124373 932892 spr0116 Streptococcus pneumoniae R6 hypothetical protein NP_357710.1 124191 D 171101 CDS NP_357711.1 15902161 932893 124392..125294 1 NC_003098.1 hypothetical protein 125294 932893 spr0117 Streptococcus pneumoniae R6 hypothetical protein NP_357711.1 124392 D 171101 CDS NP_357712.1 15902162 932899 125317..125703 1 NC_003098.1 hypothetical protein 125703 932899 spr0118 Streptococcus pneumoniae R6 hypothetical protein NP_357712.1 125317 D 171101 CDS NP_357713.1 15902163 932890 125670..126428 1 NC_003098.1 hypothetical protein 126428 932890 spr0119 Streptococcus pneumoniae R6 hypothetical protein NP_357713.1 125670 D 171101 CDS YP_008719799.1 555247345 17374504 126907..127104 1 NC_003098.1 hypothetical protein 127104 17374504 spr0119a Streptococcus pneumoniae R6 hypothetical protein YP_008719799.1 126907 D 171101 CDS NP_357714.1 15902164 932897 127503..127802 1 NC_003098.1 hypothetical protein 127802 932897 spr0120 Streptococcus pneumoniae R6 hypothetical protein NP_357714.1 127503 D 171101 CDS NP_357715.1 15902165 932894 128356..130215 1 NC_003098.1 surface protein pspA 130215 pspA 932894 pspA Streptococcus pneumoniae R6 surface protein pspA NP_357715.1 128356 D 171101 CDS NP_357716.1 15902166 932900 130562..131737 1 NC_003098.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 131737 mnmA 932900 mnmA Streptococcus pneumoniae R6 tRNA-specific 2-thiouridylase MnmA NP_357716.1 130562 D 171101 CDS NP_357717.1 15902167 932906 131851..132333 1 NC_003098.1 Similar to MutT protein; MutT/nudix family protein 132333 932906 spr0123 Streptococcus pneumoniae R6 MutT/nudix family protein NP_357717.1 131851 D 171101 CDS NP_357718.1 15902168 932898 132343..134256 1 NC_003098.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 134256 gidA 932898 gidA Streptococcus pneumoniae R6 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA NP_357718.1 132343 D 171101 CDS NP_357719.1 15902169 934629 complement(134636..136468) 1 NC_003098.1 Predicted hydrolase of the metallo-beta-lactamase superfamily; hypothetical protein 136468 934629 spr0125 Streptococcus pneumoniae R6 hypothetical protein NP_357719.1 134636 R 171101 CDS NP_357720.1 15902170 932901 complement(136317..136550) 1 NC_003098.1 hypothetical protein 136550 932901 spr0126 Streptococcus pneumoniae R6 hypothetical protein NP_357720.1 136317 R 171101 CDS NP_357721.1 15902171 934632 complement(137368..137520) 1 NC_003098.1 Induced during competence; hypothetical protein 137520 orf51 934632 orf51 Streptococcus pneumoniae R6 hypothetical protein NP_357721.1 137368 R 171101 CDS NP_357722.1 15902172 934875 complement(137522..137707) 1 NC_003098.1 hypothetical protein 137707 934875 spr0128 Streptococcus pneumoniae R6 hypothetical protein NP_357722.1 137522 R 171101 CDS NP_357723.1 15902173 932905 137885..138568 1 NC_003098.1 hypothetical protein 138568 932905 spr0129 Streptococcus pneumoniae R6 hypothetical protein NP_357723.1 137885 D 171101 CDS NP_357724.1 15902174 932904 138565..139002 1 NC_003098.1 ribosomal protein alanine acetyltransferase 139002 rimI 932904 rimI Streptococcus pneumoniae R6 ribosomal protein alanine acetyltransferase NP_357724.1 138565 D 171101 CDS NP_357725.1 15902175 934879 138992..140002 1 NC_003098.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 140002 gcp 934879 gcp Streptococcus pneumoniae R6 DNA-binding/iron metalloprotein/AP endonuclease NP_357725.1 138992 D 171101 CDS NP_357728.1 15902178 934892 complement(142041..142307) 1 NC_003098.1 degenerative transposase 142307 transposase_A 934892 transposase_A Streptococcus pneumoniae R6 degenerative transposase NP_357728.1 142041 R 171101 CDS NP_357729.1 15902179 934883 142595..143809 1 NC_003098.1 exopolysaccharide (EPS) synthesis glycosyltransferase 143809 epsG 934883 epsG Streptococcus pneumoniae R6 exopolysaccharide (EPS) synthesis glycosyltransferase NP_357729.1 142595 D 171101 CDS NP_357730.1 15902180 934876 143802..144755 1 NC_003098.1 glycosyl transferase 144755 glycosyltransferase 934876 glycosyltransferase Streptococcus pneumoniae R6 glycosyl transferase NP_357730.1 143802 D 171101 CDS NP_357731.1 15902181 934878 144765..146381 1 NC_003098.1 ABC transporter ATP-binding protein 146381 ABC-NP 934878 ABC-NP Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_357731.1 144765 D 171101 CDS NP_357732.1 15902182 934887 147164..147919 1 NC_003098.1 hypothetical protein 147919 934887 spr0138 Streptococcus pneumoniae R6 hypothetical protein NP_357732.1 147164 D 171101 CDS NP_357733.1 15902183 934890 147932..149104 1 NC_003098.1 UDP-glucose dehydrogenase 149104 ugd 934890 ugd Streptococcus pneumoniae R6 UDP-glucose dehydrogenase NP_357733.1 147932 D 171101 CDS NP_357734.1 15902184 934880 149499..150362 1 NC_003098.1 transcriptional regulator 150362 mutR 934880 mutR Streptococcus pneumoniae R6 transcriptional regulator NP_357734.1 149499 D 171101 CDS NP_357735.1 15902185 934894 150653..150886 1 NC_003098.1 hypothetical protein 150886 934894 spr0141 Streptococcus pneumoniae R6 hypothetical protein NP_357735.1 150653 D 171101 CDS NP_357736.1 15902186 934881 150908..151585 1 NC_003098.1 hypothetical protein 151585 934881 spr0142 Streptococcus pneumoniae R6 hypothetical protein NP_357736.1 150908 D 171101 CDS NP_357737.1 15902187 934885 151597..152262 1 NC_003098.1 hypothetical protein 152262 934885 spr0143 Streptococcus pneumoniae R6 hypothetical protein NP_357737.1 151597 D 171101 CDS NP_357738.1 15902188 934888 152331..153560 1 NC_003098.1 hypothetical protein 153560 934888 spr0144 Streptococcus pneumoniae R6 hypothetical protein NP_357738.1 152331 D 171101 CDS NP_357739.1 15902189 934882 153770..154366 1 NC_003098.1 hypothetical protein 154366 934882 spr0145 Streptococcus pneumoniae R6 hypothetical protein NP_357739.1 153770 D 171101 CDS NP_357740.1 15902190 934902 154470..155300 1 NC_003098.1 amino acid ABC transporter substrate-binding protein 155300 ABC-SBP 934902 ABC-SBP Streptococcus pneumoniae R6 amino acid ABC transporter substrate-binding protein NP_357740.1 154470 D 171101 CDS NP_357741.1 15902191 934877 155454..156308 1 NC_003098.1 lipoprotein 156308 ABC-SBP 934877 ABC-SBP Streptococcus pneumoniae R6 lipoprotein NP_357741.1 155454 D 171101 CDS NP_357742.1 15902192 934884 156408..157781 1 NC_003098.1 hypothetical protein 157781 dapE 934884 dapE Streptococcus pneumoniae R6 hypothetical protein NP_357742.1 156408 D 171101 CDS NP_357743.1 15902193 934901 157774..158835 1 NC_003098.1 ABC transporter ATP-binding protein 158835 ABC-NBD 934901 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_357743.1 157774 D 171101 CDS NP_357744.1 15902194 934898 158837..159529 1 NC_003098.1 ABC transporter permease 159529 ABC-MSD 934898 ABC-MSD Streptococcus pneumoniae R6 ABC transporter permease NP_357744.1 158837 D 171101 CDS NP_357745.1 15902195 934904 complement(159559..160128) 1 NC_003098.1 hypothetical protein 160128 934904 spr0151 Streptococcus pneumoniae R6 hypothetical protein NP_357745.1 159559 R 171101 CDS NP_357746.1 15902196 934895 160263..160877 1 NC_003098.1 hypothetical protein 160877 934895 spr0152 Streptococcus pneumoniae R6 hypothetical protein NP_357746.1 160263 D 171101 CDS NP_357747.2 555247343 934900 160855..162525 1 NC_003098.1 histidine kinase 162525 hk07 934900 hk07 Streptococcus pneumoniae R6 histidine kinase NP_357747.2 160855 D 171101 CDS NP_357748.1 15902198 934903 162537..163823 1 NC_003098.1 DNA-binding response regulator 163823 rr07 934903 rr07 Streptococcus pneumoniae R6 DNA-binding response regulator NP_357748.1 162537 D 171101 CDS NP_357749.1 15902199 934897 163827..164408 1 NC_003098.1 hypothetical protein 164408 934897 spr0155 Streptococcus pneumoniae R6 hypothetical protein NP_357749.1 163827 D 171101 CDS NP_357750.1 15902200 934899 164354..164956 1 NC_003098.1 has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; flavoprotein NrdI 164956 934899 spr0156 Streptococcus pneumoniae R6 flavoprotein NrdI NP_357750.1 164354 D 171101 CDS NP_357751.1 15902201 934021 complement(165249..166511) 1 NC_003098.1 hypothetical protein 166511 934021 spr0157 Streptococcus pneumoniae R6 hypothetical protein NP_357751.1 165249 R 171101 CDS NP_357752.1 15902202 932902 complement(166821..167279) 1 NC_003098.1 hypothetical protein 167279 932902 spr0158 Streptococcus pneumoniae R6 hypothetical protein NP_357752.1 166821 R 171101 CDS NP_357753.1 15902203 934023 complement(167276..167797) 1 NC_003098.1 Similar to autolysin response regulator in Bacillus subtilis; hypothetical protein 167797 934023 spr0159 Streptococcus pneumoniae R6 hypothetical protein NP_357753.1 167276 R 171101 CDS NP_357754.1 15902204 934896 168072..170021 1 NC_003098.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 170021 mutL 934896 mutL Streptococcus pneumoniae R6 DNA mismatch repair protein NP_357754.1 168072 D 171101 CDS NP_357755.1 15902205 933803 complement(170346..170813) 1 NC_003098.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 170813 ribH 933803 ribH Streptococcus pneumoniae R6 6,7-dimethyl-8-ribityllumazine synthase NP_357755.1 170346 R 171101 CDS NP_357756.1 15902206 934025 complement(170814..172019) 1 NC_003098.1 3,4-dihydroxy-2-butanone 4-phosphate synthase 172019 ribA 934025 ribA Streptococcus pneumoniae R6 3,4-dihydroxy-2-butanone 4-phosphate synthase NP_357756.1 170814 R 171101 CDS NP_357757.1 15902207 933132 complement(172039..172674) 1 NC_003098.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 172674 ribC 933132 ribC Streptococcus pneumoniae R6 riboflavin synthase subunit alpha NP_357757.1 172039 R 171101 CDS NP_357758.1 15902208 933106 complement(172659..173759) 1 NC_003098.1 riboflavin biosynthesis protein RibD 173759 ribD 933106 ribD Streptococcus pneumoniae R6 riboflavin biosynthesis protein RibD NP_357758.1 172659 R 171101 CDS NP_357759.1 15902209 933035 174163..174756 1 NC_003098.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 174756 ruvA 933035 ruvA Streptococcus pneumoniae R6 Holliday junction DNA helicase RuvA NP_357759.1 174163 D 171101 CDS NP_357760.1 15902210 933894 174766..175329 1 NC_003098.1 DNA-3-methyladenine glycosylase I 175329 tag 933894 tag Streptococcus pneumoniae R6 DNA-3-methyladenine glycosylase I NP_357760.1 174766 D 171101 CDS NP_357761.1 15902211 932875 175326..176003 1 NC_003098.1 hypothetical protein 176003 932875 spr0167 Streptococcus pneumoniae R6 hypothetical protein NP_357761.1 175326 D 171101 CDS NP_357762.1 15902212 933807 complement(176158..177189) 1 NC_003098.1 MccF-like proteins; MccC family protein 177189 933807 spr0168 Streptococcus pneumoniae R6 MccC family protein NP_357762.1 176158 R 171101 CDS NP_357763.1 15902213 933844 complement(177444..178148) 1 NC_003098.1 hypothetical protein 178148 933844 spr0169 Streptococcus pneumoniae R6 hypothetical protein NP_357763.1 177444 R 171101 CDS NP_357764.1 15902214 933183 complement(178139..179083) 1 NC_003098.1 magnesium/cobalt transporter CorA 179083 corA 933183 corA Streptococcus pneumoniae R6 magnesium/cobalt transporter CorA NP_357764.1 178139 R 171101 CDS NP_357765.1 15902215 933838 179215..182046 1 NC_003098.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 182046 uvrA 933838 uvrA Streptococcus pneumoniae R6 excinuclease ABC subunit A NP_357765.1 179215 D 171101 CDS NP_357766.1 15902216 933987 182039..183100 1 NC_003098.1 peptidase M24 family protein 183100 pepP 933987 pepP Streptococcus pneumoniae R6 peptidase M24 family protein NP_357766.1 182039 D 171101 CDS NP_357767.1 15902217 933168 183232..183630 1 NC_003098.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 183630 spxA 933168 spxA Streptococcus pneumoniae R6 transcriptional regulator Spx NP_357767.1 183232 D 171101 CDS NP_357768.1 15902218 933777 183696..184265 1 NC_003098.1 hypothetical protein 184265 933777 spr0174 Streptococcus pneumoniae R6 hypothetical protein NP_357768.1 183696 D 171101 CDS NP_357769.1 15902219 933164 184352..184618 1 NC_003098.1 hypothetical protein 184618 933164 spr0175 Streptococcus pneumoniae R6 hypothetical protein NP_357769.1 184352 D 171101 CDS NP_357770.1 15902220 933212 184622..185041 1 NC_003098.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 185041 933212 spr0176 Streptococcus pneumoniae R6 Holliday junction resolvase-like protein NP_357770.1 184622 D 171101 CDS NP_357771.1 15902221 933178 185057..185362 1 NC_003098.1 hypothetical protein 185362 933178 spr0177 Streptococcus pneumoniae R6 hypothetical protein NP_357771.1 185057 D 171101 CDS NP_357772.1 15902222 933972 185813..187069 1 NC_003098.1 dihydrofolate:folylpolyglutamate synthetase 187069 folC 933972 folC Streptococcus pneumoniae R6 dihydrofolate:folylpolyglutamate synthetase NP_357772.1 185813 D 171101 CDS NP_357773.1 15902223 932873 187066..187584 1 NC_003098.1 hypothetical protein 187584 932873 spr0179 Streptococcus pneumoniae R6 hypothetical protein NP_357773.1 187066 D 171101 CDS NP_357774.1 15902224 933187 187730..189262 1 NC_003098.1 cardiolipin synthetase 189262 cls 933187 cls Streptococcus pneumoniae R6 cardiolipin synthetase NP_357774.1 187730 D 171101 CDS NP_357775.1 15902225 933180 189340..189483 1 NC_003098.1 Induced during competence; hypothetical protein 189483 orf47 933180 orf47 Streptococcus pneumoniae R6 hypothetical protein NP_357775.1 189340 D 171101 CDS NP_357776.1 15902226 932988 189502..191058 1 NC_003098.1 Competence-induced protein Ccs4; competence-induced protein Ccs4 191058 932988 spr0182 Streptococcus pneumoniae R6 competence-induced protein Ccs4 NP_357776.1 189502 D 171101 CDS NP_357777.1 15902227 932922 191172..193385 1 NC_003098.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 193385 nrdD 932922 nrdD Streptococcus pneumoniae R6 anaerobic ribonucleoside triphosphate reductase NP_357777.1 191172 D 171101 CDS NP_357778.1 15902228 932982 193581..194087 1 NC_003098.1 Similar to histone acetyltransferase HPA2 and related acetyltransferases; hypothetical protein 194087 932982 spr0184 Streptococcus pneumoniae R6 hypothetical protein NP_357778.1 193581 D 171101 CDS NP_357779.1 15902229 932981 194080..194670 1 NC_003098.1 anaerobic ribonucleoside-triphosphate reductase activating protein 194670 nrdG 932981 nrdG Streptococcus pneumoniae R6 anaerobic ribonucleoside-triphosphate reductase activating protein NP_357779.1 194080 D 171101 CDS NP_357780.1 15902230 933102 194667..195284 1 NC_003098.1 hypothetical protein 195284 933102 spr0186 Streptococcus pneumoniae R6 hypothetical protein NP_357780.1 194667 D 171101 CDS NP_357781.1 15902231 932811 195551..195859 1 NC_003098.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 195859 rpsJ 932811 rpsJ Streptococcus pneumoniae R6 30S ribosomal protein S10 NP_357781.1 195551 D 171101 CDS NP_357782.1 15902232 932979 196076..196702 1 NC_003098.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 196702 rplC 932979 rplC Streptococcus pneumoniae R6 50S ribosomal protein L3 NP_357782.1 196076 D 171101 CDS NP_357783.1 15902233 933169 196727..197350 1 NC_003098.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 197350 rplD 933169 rplD Streptococcus pneumoniae R6 50S ribosomal protein L4 NP_357783.1 196727 D 171101 CDS NP_357784.1 15902234 932965 197350..197646 1 NC_003098.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 197646 rplW 932965 rplW Streptococcus pneumoniae R6 50S ribosomal protein L23 NP_357784.1 197350 D 171101 CDS NP_357785.1 15902235 933760 197664..198497 1 NC_003098.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 198497 rplB 933760 rplB Streptococcus pneumoniae R6 50S ribosomal protein L2 NP_357785.1 197664 D 171101 CDS NP_357786.1 15902236 932870 198601..198882 1 NC_003098.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 198882 rpsS 932870 rpsS Streptococcus pneumoniae R6 30S ribosomal protein S19 NP_357786.1 198601 D 171101 CDS NP_357788.1 15902238 932936 198894..199238 1 NC_003098.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 199238 rplV 932936 rplV Streptococcus pneumoniae R6 50S ribosomal protein L22 NP_357788.1 198894 D 171101 CDS NP_357789.1 15902239 933129 199251..199904 1 NC_003098.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 199904 rpsC 933129 rpsC Streptococcus pneumoniae R6 30S ribosomal protein S3 NP_357789.1 199251 D 171101 CDS NP_357790.1 15902240 933103 199908..200321 1 NC_003098.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 200321 rplP 933103 rplP Streptococcus pneumoniae R6 50S ribosomal protein L16 NP_357790.1 199908 D 171101 CDS NP_357791.1 15902241 933478 200331..200537 1 NC_003098.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 200537 rpmC 933478 rpmC Streptococcus pneumoniae R6 50S ribosomal protein L29 NP_357791.1 200331 D 171101 CDS NP_357792.1 15902242 932999 200562..200822 1 NC_003098.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 200822 rpsQ 932999 rpsQ Streptococcus pneumoniae R6 30S ribosomal protein S17 NP_357792.1 200562 D 171101 CDS NP_357793.1 15902243 933923 200848..201216 1 NC_003098.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 201216 rplN 933923 rplN Streptococcus pneumoniae R6 50S ribosomal protein L14 NP_357793.1 200848 D 171101 CDS NP_357794.1 15902244 933260 201294..201599 1 NC_003098.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 201599 rplX 933260 rplX Streptococcus pneumoniae R6 50S ribosomal protein L24 NP_357794.1 201294 D 171101 CDS NP_357795.1 15902245 932791 201623..202165 1 NC_003098.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 202165 rplE 932791 rplE Streptococcus pneumoniae R6 50S ribosomal protein L5 NP_357795.1 201623 D 171101 CDS NP_357796.1 15902246 933061 202183..202452 1 NC_003098.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 202452 rpsN 933061 rpsN Streptococcus pneumoniae R6 30S ribosomal protein S14 NP_357796.1 202183 D 171101 CDS NP_357797.1 15902247 933398 202737..203135 1 NC_003098.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 203135 rpsH 933398 rpsH Streptococcus pneumoniae R6 30S ribosomal protein S8 NP_357797.1 202737 D 171101 CDS NP_357798.1 15902248 933505 203327..203863 1 NC_003098.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 203863 rplF 933505 rplF Streptococcus pneumoniae R6 50S ribosomal protein L6 NP_357798.1 203327 D 171101 CDS NP_357799.1 15902249 933766 203947..204303 1 NC_003098.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 204303 rplR 933766 rplR Streptococcus pneumoniae R6 50S ribosomal protein L18 NP_357799.1 203947 D 171101 CDS NP_357800.1 15902250 933812 204321..204815 1 NC_003098.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 204815 rpsE 933812 rpsE Streptococcus pneumoniae R6 30S ribosomal protein S5 NP_357800.1 204321 D 171101 CDS NP_357801.1 15902251 933890 204829..205011 1 NC_003098.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 205011 rpmD 933890 rpmD Streptococcus pneumoniae R6 50S ribosomal protein L30 NP_357801.1 204829 D 171101 CDS NP_357802.1 15902252 933940 205156..205596 1 NC_003098.1 late assembly protein; 50S ribosomal protein L15 205596 rplO 933940 rplO Streptococcus pneumoniae R6 50S ribosomal protein L15 NP_357802.1 205156 D 171101 CDS NP_357803.1 15902253 933437 205609..206919 1 NC_003098.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 206919 secY 933437 secY Streptococcus pneumoniae R6 preprotein translocase subunit SecY NP_357803.1 205609 D 171101 CDS NP_357804.1 15902254 933789 207070..207708 1 NC_003098.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 207708 adk 933789 adk Streptococcus pneumoniae R6 adenylate kinase NP_357804.1 207070 D 171101 CDS NP_357805.2 555247342 932927 207825..208043 1 NC_003098.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 208043 infA 932927 infA Streptococcus pneumoniae R6 translation initiation factor IF-1 NP_357805.2 207825 D 171101 CDS NP_357806.1 15902256 933957 208068..208184 1 NC_003098.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 208184 rpmJ 933957 rpmJ Streptococcus pneumoniae R6 50S ribosomal protein L36 NP_357806.1 208068 D 171101 CDS NP_357807.1 15902257 933973 208202..208567 1 NC_003098.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 208567 rpsM 933973 rpsM Streptococcus pneumoniae R6 30S ribosomal protein S13 NP_357807.1 208202 D 171101 CDS NP_357808.1 15902258 933403 208585..208968 1 NC_003098.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 208968 rpsK 933403 rpsK Streptococcus pneumoniae R6 30S ribosomal protein S11 NP_357808.1 208585 D 171101 CDS NP_357809.1 15902259 933822 209011..209946 1 NC_003098.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 209946 rpoA 933822 rpoA Streptococcus pneumoniae R6 DNA-directed RNA polymerase subunit alpha NP_357809.1 209011 D 171101 CDS NP_357810.1 15902260 933143 209958..210344 1 NC_003098.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 210344 rplQ 933143 rplQ Streptococcus pneumoniae R6 50S ribosomal protein L17 NP_357810.1 209958 D 171101 CDS NP_357811.2 161410756 933047 210609..210875 1 NC_003098.1 ACT domain-containing protein; hypothetical protein 210875 933047 spr0217 Streptococcus pneumoniae R6 hypothetical protein NP_357811.2 210609 D 171101 CDS NP_357812.1 15902262 933558 210885..212222 1 NC_003098.1 hypothetical protein 212222 933558 spr0218 Streptococcus pneumoniae R6 hypothetical protein NP_357812.1 210885 D 171101 CDS NP_357813.1 15902263 933096 212409..213158 1 NC_003098.1 phosphoglycerate mutase 213158 gpmB 933096 gpmB Streptococcus pneumoniae R6 phosphoglycerate mutase NP_357813.1 212409 D 171101 CDS NP_357814.1 15902264 933873 complement(213261..214295) 1 NC_003098.1 iron ABC transporter permease 214295 ABC-MSP 933873 ABC-MSP Streptococcus pneumoniae R6 iron ABC transporter permease NP_357814.1 213261 R 171101 CDS NP_357815.1 15902265 933823 complement(214280..214906) 1 NC_003098.1 iron ABC transporter permease 214906 ABC-MSP 933823 ABC-MSP Streptococcus pneumoniae R6 iron ABC transporter permease NP_357815.1 214280 R 171101 CDS NP_357816.1 15902266 933981 complement(214896..215987) 1 NC_003098.1 ABC transporter ATP-binding protein 215987 ABC-NBD 933981 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_357816.1 214896 R 171101 CDS NP_357819.1 15902269 932975 complement(217339..217536) 1 NC_003098.1 hypothetical protein 217536 932975 spr0225 Streptococcus pneumoniae R6 hypothetical protein NP_357819.1 217339 R 171101 CDS NP_357820.1 15902270 933787 complement(217611..218387) 1 NC_003098.1 pyruvate formate-lyase 3 218387 pflE 933787 pflE Streptococcus pneumoniae R6 pyruvate formate-lyase 3 NP_357820.1 217611 R 171101 CDS NP_357821.1 15902271 933802 218461..219255 1 NC_003098.1 DEOR-type transcriptional regulator 219255 deoR 933802 deoR Streptococcus pneumoniae R6 DEOR-type transcriptional regulator NP_357821.1 218461 D 171101 CDS NP_357822.1 15902272 932868 219268..220248 1 NC_003098.1 Resembles sorbitol operon regulator; hypothetical protein 220248 932868 spr0228 Streptococcus pneumoniae R6 hypothetical protein NP_357822.1 219268 D 171101 CDS NP_357823.1 15902273 933017 220443..220763 1 NC_003098.1 PTS system transporter subunit IIA 220763 PTS-EIIA 933017 PTS-EIIA Streptococcus pneumoniae R6 PTS system transporter subunit IIA NP_357823.1 220443 D 171101 CDS NP_357824.1 15902274 933950 220809..221117 1 NC_003098.1 PTS system transporter subunit IIB 221117 PTS-EIIB 933950 PTS-EIIB Streptococcus pneumoniae R6 PTS system transporter subunit IIB NP_357824.1 220809 D 171101 CDS NP_357825.1 15902275 934634 221110..222432 1 NC_003098.1 PTS system transporter subunit IIC 222432 PTS-EIIC 934634 PTS-EIIC Streptococcus pneumoniae R6 PTS system transporter subunit IIC NP_357825.1 221110 D 171101 CDS NP_357826.1 15902276 932996 222574..225021 1 NC_003098.1 formate acetyltransferase 3 225021 pflF 932996 pflF Streptococcus pneumoniae R6 formate acetyltransferase 3 NP_357826.1 222574 D 171101 CDS NP_357827.1 15902277 933429 225040..225708 1 NC_003098.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 225708 talC 933429 talC Streptococcus pneumoniae R6 fructose-6-phosphate aldolase NP_357827.1 225040 D 171101 CDS NP_357828.1 15902278 934143 225726..226814 1 NC_003098.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 226814 gldA 934143 gldA Streptococcus pneumoniae R6 glycerol dehydrogenase NP_357828.1 225726 D 171101 CDS NP_357829.1 15902279 934057 227269..229770 1 NC_003098.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 229770 leuS 934057 leuS Streptococcus pneumoniae R6 leucyl-tRNA synthetase NP_357829.1 227269 D 171101 CDS NP_357830.1 15902280 933481 229964..230659 1 NC_003098.1 Similar to acetyltransferases, including N-acetylases of ribosomal proteins; hypothetical protein 230659 933481 spr0236 Streptococcus pneumoniae R6 hypothetical protein NP_357830.1 229964 D 171101 CDS NP_357831.1 15902281 934635 230671..231087 1 NC_003098.1 Similar to histone acetyltransferase HPA2 and related acetyltransferases; hypothetical protein 231087 934635 spr0237 Streptococcus pneumoniae R6 hypothetical protein NP_357831.1 230671 D 171101 CDS NP_357832.1 15902282 934147 232128..233126 1 NC_003098.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 233126 ruvB 934147 ruvB Streptococcus pneumoniae R6 Holliday junction DNA helicase RuvB NP_357832.1 232128 D 171101 CDS NP_357833.1 15902283 933735 233107..233679 1 NC_003098.1 hypothetical protein 233679 933735 spr0239 Streptococcus pneumoniae R6 hypothetical protein NP_357833.1 233107 D 171101 CDS NP_357834.1 15902284 934063 233892..234668 1 NC_003098.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 234668 uppS 934063 uppS Streptococcus pneumoniae R6 undecaprenyl pyrophosphate synthase NP_357834.1 233892 D 171101 CDS NP_357835.1 15902285 934160 234677..235480 1 NC_003098.1 phosphatidate cytidylyltransferase 235480 cdsA 934160 cdsA Streptococcus pneumoniae R6 phosphatidate cytidylyltransferase NP_357835.1 234677 D 171101 CDS NP_357836.1 15902286 933841 235502..236761 1 NC_003098.1 determinant for enhanced expression of pheromone 236761 eep 933841 eep Streptococcus pneumoniae R6 determinant for enhanced expression of pheromone NP_357836.1 235502 D 171101 CDS NP_357837.1 15902287 933853 236774..238627 1 NC_003098.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 238627 proS 933853 proS Streptococcus pneumoniae R6 prolyl-tRNA synthetase NP_357837.1 236774 D 171101 CDS NP_357838.1 15902288 932970 238727..240106 1 NC_003098.1 6-phospho-beta-glucosidase 240106 bglA 932970 bglA Streptococcus pneumoniae R6 6-phospho-beta-glucosidase NP_357838.1 238727 D 171101 CDS NP_357839.1 15902289 932810 240298..242106 1 NC_003098.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 242106 glmS 932810 glmS Streptococcus pneumoniae R6 glucosamine--fructose-6-phosphate aminotransferase NP_357839.1 240298 D 171101 CDS NP_357840.1 15902290 933939 242225..243274 1 NC_003098.1 Similar to coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and and related flavin-dependent oxidoreductases; hypothetical protein 243274 933939 spr0246 Streptococcus pneumoniae R6 hypothetical protein NP_357840.1 242225 D 171101 CDS NP_357841.1 15902291 933840 complement(243374..247144) 1 NC_003098.1 alkaline amylopullulanase 247144 pulA 933840 pulA Streptococcus pneumoniae R6 alkaline amylopullulanase NP_357841.1 243374 R 171101 CDS NP_357842.1 15902292 934814 247561..247974 1 NC_003098.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 247974 rpsL 934814 rpsL Streptococcus pneumoniae R6 30S ribosomal protein S12 NP_357842.1 247561 D 171101 CDS NP_357843.1 15902293 933759 247994..248464 1 NC_003098.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 248464 rpsG 933759 rpsG Streptococcus pneumoniae R6 30S ribosomal protein S7 NP_357843.1 247994 D 171101 CDS NP_357844.1 15902294 933055 248889..250970 1 NC_003098.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 250970 fusA 933055 fusA Streptococcus pneumoniae R6 elongation factor G NP_357844.1 248889 D 171101 CDS NP_357845.1 15902295 934637 251074..255465 1 NC_003098.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 255465 polC 934637 polC Streptococcus pneumoniae R6 DNA polymerase III PolC NP_357845.1 251074 D 171101 CDS NP_357846.1 15902296 933022 255567..255830 1 NC_003098.1 hypothetical protein 255830 933022 spr0252 Streptococcus pneumoniae R6 hypothetical protein NP_357846.1 255567 D 171101 CDS NP_357847.1 15902297 932971 255823..256101 1 NC_003098.1 hypothetical protein 256101 932971 spr0253 Streptococcus pneumoniae R6 hypothetical protein NP_357847.1 255823 D 171101 CDS NP_357848.1 15902298 934836 256296..257537 1 NC_003098.1 aminopeptidase 257537 pepS 934836 pepS Streptococcus pneumoniae R6 aminopeptidase NP_357848.1 256296 D 171101 CDS NP_357849.1 15902299 934172 257547..257777 1 NC_003098.1 hypothetical protein 257777 934172 spr0255 Streptococcus pneumoniae R6 hypothetical protein NP_357849.1 257547 D 171101 CDS NP_357850.1 15902300 933942 258090..258812 1 NC_003098.1 ribosomal small subunit pseudouridine synthase A 258812 rsuA 933942 rsuA Streptococcus pneumoniae R6 ribosomal small subunit pseudouridine synthase A NP_357850.1 258090 D 171101 CDS NP_357851.1 15902301 934764 258893..259057 1 NC_003098.1 hypothetical protein 259057 934764 spr0257 Streptococcus pneumoniae R6 hypothetical protein NP_357851.1 258893 D 171101 CDS NP_357852.1 15902302 934645 259029..260363 1 NC_003098.1 aminopeptidase 260363 pepC 934645 pepC Streptococcus pneumoniae R6 aminopeptidase NP_357852.1 259029 D 171101 CDS NP_357853.1 15902303 934837 complement(260419..261330) 1 NC_003098.1 PTS system mannose-specific transporter subunit EIID 261330 manN 934837 manN Streptococcus pneumoniae R6 PTS system mannose-specific transporter subunit EIID NP_357853.1 260419 R 171101 CDS NP_357854.1 15902304 934638 complement(261354..262157) 1 NC_003098.1 PTS system mannose-specific transporter subunit IIC 262157 manM 934638 manM Streptococcus pneumoniae R6 PTS system mannose-specific transporter subunit IIC NP_357854.1 261354 R 171101 CDS NP_357855.1 15902305 934647 complement(262185..263183) 1 NC_003098.1 PTS system mannose-specific transporter subunit IIAB 263183 manL 934647 manL Streptococcus pneumoniae R6 PTS system mannose-specific transporter subunit IIAB NP_357855.1 262185 R 171101 CDS NP_357856.1 15902306 934639 complement(263358..264377) 1 NC_003098.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 264377 adhP 934639 adhP Streptococcus pneumoniae R6 alcohol dehydrogenase NP_357856.1 263358 R 171101 CDS NP_357857.1 15902307 934654 complement(264716..265528) 1 NC_003098.1 Cof family protein 265528 934654 spr0263 Streptococcus pneumoniae R6 Cof family protein NP_357857.1 264716 R 171101 CDS NP_357858.1 15902308 934650 265664..267136 1 NC_003098.1 xanthine/uracil permease 267136 934650 spr0264 Streptococcus pneumoniae R6 xanthine/uracil permease NP_357858.1 265664 D 171101 CDS NP_357859.1 15902309 934648 267187..267897 1 NC_003098.1 hypothetical protein 267897 934648 spr0265 Streptococcus pneumoniae R6 hypothetical protein NP_357859.1 267187 D 171101 CDS NP_357860.1 15902310 934662 268022..268966 1 NC_003098.1 dihydropteroate synthase 268966 sulA 934662 sulA Streptococcus pneumoniae R6 dihydropteroate synthase NP_357860.1 268022 D 171101 CDS NP_357861.1 15902311 934661 268968..270290 1 NC_003098.1 dihydrofolate synthetase 270290 sulB 934661 sulB Streptococcus pneumoniae R6 dihydrofolate synthetase NP_357861.1 268968 D 171101 CDS NP_357862.1 15902312 934652 270271..270825 1 NC_003098.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 270825 folE 934652 folE Streptococcus pneumoniae R6 GTP cyclohydrolase I NP_357862.1 270271 D 171101 CDS NP_357863.1 15902313 934668 270868..271680 1 NC_003098.1 bifunctional folate synthesis protein 271680 sulD 934668 sulD Streptococcus pneumoniae R6 bifunctional folate synthesis protein NP_357863.1 270868 D 171101 CDS NP_357864.1 15902314 934659 complement(271725..272096) 1 NC_003098.1 hypothetical protein 272096 934659 spr0270 Streptococcus pneumoniae R6 hypothetical protein NP_357864.1 271725 R 171101 CDS NP_357865.1 15902315 934656 272399..272845 1 NC_003098.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 272845 rplM 934656 rplM Streptococcus pneumoniae R6 50S ribosomal protein L13 NP_357865.1 272399 D 171101 CDS NP_357866.1 15902316 934684 272865..273257 1 NC_003098.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 273257 rpsI 934684 rpsI Streptococcus pneumoniae R6 30S ribosomal protein S9 NP_357866.1 272865 D 171101 CDS NP_357869.1 15902319 934666 273944..274309 1 NC_003098.1 hypothetical protein 274309 934666 spr0275 Streptococcus pneumoniae R6 hypothetical protein NP_357869.1 273944 D 171101 CDS NP_357870.1 15902320 934676 274499..275935 1 NC_003098.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 275935 celA 934676 celA Streptococcus pneumoniae R6 6-phospho-beta-glucosidase NP_357870.1 274499 D 171101 CDS NP_357871.1 15902321 934690 275987..276226 1 NC_003098.1 hypothetical protein 276226 934690 spr0277 Streptococcus pneumoniae R6 hypothetical protein NP_357871.1 275987 D 171101 CDS NP_357872.2 161410755 934677 276356..276670 1 NC_003098.1 required for cellobiose uptake and metabolism; PTS system cellobiose transporter subunit IIB 276670 celB 934677 celB Streptococcus pneumoniae R6 PTS system cellobiose transporter subunit IIB NP_357872.2 276356 D 171101 CDS NP_357873.1 15902323 934694 276788..278767 1 NC_003098.1 BigG family transcription antiterminator 278767 bglG 934694 bglG Streptococcus pneumoniae R6 BigG family transcription antiterminator NP_357873.1 276788 D 171101 CDS NP_357874.1 15902324 934696 278777..279091 1 NC_003098.1 required for cellobiose uptake and metabolism; PTS system cellobiose transporter subunit IIA 279091 celC 934696 celC Streptococcus pneumoniae R6 PTS system cellobiose transporter subunit IIA NP_357874.1 278777 D 171101 CDS NP_357875.1 15902325 934682 279110..279616 1 NC_003098.1 hypothetical protein 279616 934682 spr0281 Streptococcus pneumoniae R6 hypothetical protein NP_357875.1 279110 D 171101 CDS NP_357876.1 15902326 934687 279696..281042 1 NC_003098.1 required for cellobiose uptake and metabolism; PTS system cellobiose transporter subunit IIC 281042 celD 934687 celD Streptococcus pneumoniae R6 PTS system cellobiose transporter subunit IIC NP_357876.1 279696 D 171101 CDS NP_357877.1 15902327 934700 281424..281600 1 NC_003098.1 hypothetical protein 281600 934700 spr0283 Streptococcus pneumoniae R6 hypothetical protein NP_357877.1 281424 D 171101 CDS NP_357878.1 15902328 934686 282002..284215 1 NC_003098.1 Alpha-xylosidase 284215 xylS 934686 xylS Streptococcus pneumoniae R6 Alpha-xylosidase NP_357878.1 282002 D 171101 CDS NP_357879.1 15902329 934692 complement(284437..284913) 1 NC_003098.1 glutathione peroxidase 284913 basA 934692 basA Streptococcus pneumoniae R6 glutathione peroxidase NP_357879.1 284437 R 171101 CDS NP_357880.1 15902330 934705 285103..288339 1 NC_003098.1 hyaluronate lyase 288339 hysA 934705 hysA Streptococcus pneumoniae R6 hyaluronate lyase NP_357880.1 285103 D 171101 CDS NP_357881.1 15902331 934703 complement(289483..290112) 1 NC_003098.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 290112 kdgA 934703 kdgA Streptococcus pneumoniae R6 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase NP_357881.1 289483 R 171101 CDS NP_357882.1 15902332 934712 complement(290122..291123) 1 NC_003098.1 2-keto-3-deoxygluconate kinase 291123 kdgK 934712 kdgK Streptococcus pneumoniae R6 2-keto-3-deoxygluconate kinase NP_357882.1 290122 R 171101 CDS NP_357883.1 15902333 934706 complement(291154..291795) 1 NC_003098.1 hypothetical protein 291795 934706 spr0289 Streptococcus pneumoniae R6 hypothetical protein NP_357883.1 291154 R 171101 CDS NP_357884.1 15902334 934713 complement(291814..292629) 1 NC_003098.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 292629 gno 934713 gno Streptococcus pneumoniae R6 gluconate 5-dehydrogenase NP_357884.1 291814 R 171101 CDS NP_357885.1 15902335 934720 292900..293334 1 NC_003098.1 PTS system transporter subunit IIA 293334 PTS-EII 934720 PTS-EII Streptococcus pneumoniae R6 PTS system transporter subunit IIA NP_357885.1 292900 D 171101 CDS NP_357886.1 15902336 934711 293346..294536 1 NC_003098.1 glucuronyl hydrolase 294536 ugl 934711 ugl Streptococcus pneumoniae R6 glucuronyl hydrolase NP_357886.1 293346 D 171101 CDS NP_357887.1 15902337 934726 294547..295038 1 NC_003098.1 PTS system transporter subunit IIB 295038 PTS-EII 934726 PTS-EII Streptococcus pneumoniae R6 PTS system transporter subunit IIB NP_357887.1 294547 D 171101 CDS NP_357888.1 15902338 934729 295053..295832 1 NC_003098.1 PTS system transporter subunit IIC 295832 PTS-EII 934729 PTS-EII Streptococcus pneumoniae R6 PTS system transporter subunit IIC NP_357888.1 295053 D 171101 CDS NP_357889.1 15902339 934723 295819..296637 1 NC_003098.1 PTS system transporter subunit IID 296637 PTS-EII 934723 PTS-EII Streptococcus pneumoniae R6 PTS system transporter subunit IID NP_357889.1 295819 D 171101 CDS NP_357890.1 15902340 934717 296637..296930 1 NC_003098.1 preprotein translocase, YajC subunit 296930 934717 spr0296 Streptococcus pneumoniae R6 preprotein translocase, YajC subunit NP_357890.1 296637 D 171101 CDS NP_357891.1 15902341 934735 296952..298853 1 NC_003098.1 hypothetical protein 298853 934735 spr0297 Streptococcus pneumoniae R6 hypothetical protein NP_357891.1 296952 D 171101 CDS NP_357892.1 15902342 934722 298847..299914 1 NC_003098.1 GalR family transcription regulator 299914 regR 934722 regR Streptococcus pneumoniae R6 GalR family transcription regulator NP_357892.1 298847 D 171101 CDS NP_357894.1 15902344 934742 complement(300360..300602) 1 NC_003098.1 hypothetical protein 300602 934742 spr0300 Streptococcus pneumoniae R6 hypothetical protein NP_357894.1 300360 R 171101 CDS NP_357895.1 15902345 934732 complement(300618..300812) 1 NC_003098.1 transcriptional regulator 300812 yorfE 934732 yorfE Streptococcus pneumoniae R6 transcriptional regulator NP_357895.1 300618 R 171101 CDS NP_357896.1 15902346 934733 300978..301928 1 NC_003098.1 S-adenosyl-methyltransferase MraW 301928 mraW 934733 mraW Streptococcus pneumoniae R6 S-adenosyl-methyltransferase MraW NP_357896.1 300978 D 171101 CDS NP_357897.1 15902347 934757 301940..302257 1 NC_003098.1 cell division protein FtsL 302257 ftsL 934757 ftsL Streptococcus pneumoniae R6 cell division protein FtsL NP_357897.1 301940 D 171101 CDS NP_357898.1 15902348 934744 302261..304513 1 NC_003098.1 penicillin-binding protein 2X 304513 pbpX 934744 pbpX Streptococcus pneumoniae R6 penicillin-binding protein 2X NP_357898.1 302261 D 171101 CDS NP_357899.1 15902349 934737 304515..305495 1 NC_003098.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 305495 mraY 934737 mraY Streptococcus pneumoniae R6 phospho-N-acetylmuramoyl-pentapeptide- transferase NP_357899.1 304515 D 171101 CDS NP_357901.1 15902351 934751 306052..308157 1 NC_003098.1 ATP-dependent protease ATP-binding subunit 308157 clpL 934751 clpL Streptococcus pneumoniae R6 ATP-dependent protease ATP-binding subunit NP_357901.1 306052 D 171101 CDS NP_357902.1 15902352 934756 complement(308453..308935) 1 NC_003098.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 308935 luxS 934756 luxS Streptococcus pneumoniae R6 S-ribosylhomocysteinase NP_357902.1 308453 R 171101 CDS NP_357903.1 15902353 934750 complement(309030..310514) 1 NC_003098.1 hypothetical protein 310514 934750 spr0309 Streptococcus pneumoniae R6 hypothetical protein NP_357903.1 309030 R 171101 CDS NP_357904.1 15902354 934759 310667..312274 1 NC_003098.1 glucan 1,6-alpha-glucosidase 312274 dexB 934759 dexB Streptococcus pneumoniae R6 glucan 1,6-alpha-glucosidase NP_357904.1 310667 D 171101 CDS NP_357905.1 15902355 934763 312433..312606 1 NC_003098.1 hypothetical protein 312606 934763 spr0311 Streptococcus pneumoniae R6 hypothetical protein NP_357905.1 312433 D 171101 CDS NP_357908.1 15902358 934761 313695..314657 1 NC_003098.1 hypothetical protein 314657 cps2A 934761 cps2A Streptococcus pneumoniae R6 hypothetical protein NP_357908.1 313695 D 171101 CDS NP_357909.1 15902359 934766 314551..315585 1 NC_003098.1 hypothetical protein 315585 cps2H 934766 cps2H Streptococcus pneumoniae R6 hypothetical protein NP_357909.1 314551 D 171101 CDS NP_357910.1 15902360 934782 315715..316872 1 NC_003098.1 hypothetical protein 316872 cps2I 934782 cps2I Streptococcus pneumoniae R6 hypothetical protein NP_357910.1 315715 D 171101 CDS NP_357911.1 15902361 934770 316869..318278 1 NC_003098.1 hypothetical protein 318278 cps2J 934770 cps2J Streptococcus pneumoniae R6 hypothetical protein NP_357911.1 316869 D 171101 CDS NP_357912.1 15902362 934772 318314..319552 1 NC_003098.1 hypothetical protein 319552 cps2K 934772 cps2K Streptococcus pneumoniae R6 hypothetical protein NP_357912.1 318314 D 171101 CDS NP_357913.1 15902363 934780 319581..320186 1 NC_003098.1 hypothetical protein 320186 cps2P 934780 cps2P Streptococcus pneumoniae R6 hypothetical protein NP_357913.1 319581 D 171101 CDS NP_357914.1 15902364 934775 320264..321133 1 NC_003098.1 hypothetical protein 321133 cps2L 934775 cps2L Streptococcus pneumoniae R6 hypothetical protein NP_357914.1 320264 D 171101 CDS NP_357915.1 15902365 934787 321134..321727 1 NC_003098.1 hypothetical protein 321727 cps2M 934787 cps2M Streptococcus pneumoniae R6 hypothetical protein NP_357915.1 321134 D 171101 CDS NP_357916.1 15902366 934796 321740..322789 1 NC_003098.1 dTDP-glucose-4,6-dehydratase 322789 cpsN 934796 cpsN Streptococcus pneumoniae R6 dTDP-glucose-4,6-dehydratase NP_357916.1 321740 D 171101 CDS NP_357917.1 15902367 934778 322855..323706 1 NC_003098.1 dTDP-L-rhamnose synthase 323706 cpsO 934778 cpsO Streptococcus pneumoniae R6 dTDP-L-rhamnose synthase NP_357917.1 322855 D 171101 CDS NP_357919.1 15902369 934802 324231..324680 1 NC_003098.1 hypothetical protein 324680 934802 spr0325 Streptococcus pneumoniae R6 hypothetical protein NP_357919.1 324231 D 171101 CDS NP_357920.1 15902370 934785 324751..324909 1 NC_003098.1 hypothetical protein 324909 934785 spr0326 Streptococcus pneumoniae R6 hypothetical protein NP_357920.1 324751 D 171101 CDS NP_357921.1 15902371 934786 325111..327093 1 NC_003098.1 oligopeptide ABC transporter substrate-binding protein 327093 aliA 934786 aliA Streptococcus pneumoniae R6 oligopeptide ABC transporter substrate-binding protein NP_357921.1 325111 D 171101 CDS NP_357922.1 15902372 934804 327393..332696 1 NC_003098.1 cell wall surface anchor family protein 332696 934804 spr0328 Streptococcus pneumoniae R6 cell wall surface anchor family protein NP_357922.1 327393 D 171101 CDS NP_357923.1 15902373 934791 complement(332863..335022) 1 NC_003098.1 penicillin-binding protein 1A 335022 pbpA 934791 pbpA Streptococcus pneumoniae R6 penicillin-binding protein 1A NP_357923.1 332863 R 171101 CDS NP_357924.1 15902374 934793 complement(335019..335615) 1 NC_003098.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease 335615 recU 934793 recU Streptococcus pneumoniae R6 Holliday junction-specific endonuclease NP_357924.1 335019 R 171101 CDS NP_357925.1 15902375 934808 335681..336208 1 NC_003098.1 hypothetical protein 336208 934808 spr0331 Streptococcus pneumoniae R6 hypothetical protein NP_357925.1 335681 D 171101 CDS NP_357926.1 15902376 934797 336266..336607 1 NC_003098.1 hypothetical protein 336607 934797 spr0332 Streptococcus pneumoniae R6 hypothetical protein NP_357926.1 336266 D 171101 CDS NP_357927.1 15902377 934806 337078..338250 1 NC_003098.1 hypothetical protein 338250 934806 spr0333 Streptococcus pneumoniae R6 hypothetical protein NP_357927.1 337078 D 171101 CDS NP_357928.1 15902378 934807 338263..339657 1 NC_003098.1 hypothetical protein 339657 934807 spr0334 Streptococcus pneumoniae R6 hypothetical protein NP_357928.1 338263 D 171101 CDS NP_357929.1 15902379 934817 339733..341157 1 NC_003098.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 341157 gnd 934817 gnd Streptococcus pneumoniae R6 6-phosphogluconate dehydrogenase NP_357929.1 339733 D 171101 CDS NP_357930.1 15902380 934805 341169..341858 1 NC_003098.1 DNA-binding response regulator 341858 csrR 934805 csrR Streptococcus pneumoniae R6 DNA-binding response regulator NP_357930.1 341169 D 171101 CDS NP_357931.1 15902381 934810 341956..342972 1 NC_003098.1 choline-binding protein F 342972 cbpF 934810 cbpF Streptococcus pneumoniae R6 choline-binding protein F NP_357931.1 341956 D 171101 CDS NP_357932.1 15902382 934821 343094..343972 1 NC_003098.1 mevalonate kinase 343972 mvk 934821 mvk Streptococcus pneumoniae R6 mevalonate kinase NP_357932.1 343094 D 171101 CDS NP_357933.1 15902383 934816 343873..344907 1 NC_003098.1 diphosphomevalonate decarboxylase 344907 mvd1 934816 mvd1 Streptococcus pneumoniae R6 diphosphomevalonate decarboxylase NP_357933.1 343873 D 171101 CDS NP_357934.1 15902384 934823 344894..345901 1 NC_003098.1 phosphomevalonate kinase 345901 mvaK2 934823 mvaK2 Streptococcus pneumoniae R6 phosphomevalonate kinase NP_357934.1 344894 D 171101 CDS NP_357935.1 15902385 934831 345885..346895 1 NC_003098.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 346895 fni 934831 fni Streptococcus pneumoniae R6 isopentenyl pyrophosphate isomerase NP_357935.1 345885 D 171101 CDS NP_357936.1 15902386 934819 346973..347671 1 NC_003098.1 hypothetical protein 347671 934819 spr0342 Streptococcus pneumoniae R6 hypothetical protein NP_357936.1 346973 D 171101 CDS NP_357937.1 15902387 934820 347668..348663 1 NC_003098.1 sensor histidine kinase 348663 hk03 934820 hk03 Streptococcus pneumoniae R6 sensor histidine kinase NP_357937.1 347668 D 171101 CDS NP_357938.1 15902388 934829 348677..349309 1 NC_003098.1 DNA-binding response regulator 349309 rr03 934829 rr03 Streptococcus pneumoniae R6 DNA-binding response regulator NP_357938.1 348677 D 171101 CDS NP_357942.1 15902392 934818 350229..350423 1 NC_003098.1 hypothetical protein 350423 934818 spr0348 Streptococcus pneumoniae R6 hypothetical protein NP_357942.1 350229 D 171101 CDS NP_357945.1 15902395 934801 351393..352277 1 NC_003098.1 choline-binding protein 352277 pcpC 934801 pcpC Streptococcus pneumoniae R6 choline-binding protein NP_357945.1 351393 D 171101 CDS NP_357950.1 15902400 934701 353760..355529 1 NC_003098.1 PTS system mannitol-specific transporter subunit IIBC 355529 mtlA 934701 mtlA Streptococcus pneumoniae R6 PTS system mannitol-specific transporter subunit IIBC NP_357950.1 353760 D 171101 CDS NP_357951.1 15902401 934715 355553..357508 1 NC_003098.1 transcriptional regulator 357508 934715 spr0357 Streptococcus pneumoniae R6 transcriptional regulator NP_357951.1 355553 D 171101 CDS NP_357952.1 15902402 932976 357510..357947 1 NC_003098.1 PTS system mannitol-specific transporter subunit IIA 357947 mtlF 932976 mtlF Streptococcus pneumoniae R6 PTS system mannitol-specific transporter subunit IIA NP_357952.1 357510 D 171101 CDS NP_357953.1 15902403 933124 358009..359145 1 NC_003098.1 mannitol-1-phosphate 5-dehydrogenase 359145 mtlD 933124 mtlD Streptococcus pneumoniae R6 mannitol-1-phosphate 5-dehydrogenase NP_357953.1 358009 D 171101 CDS NP_357956.1 15902406 933930 359944..361227 1 NC_003098.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 361227 tig 933930 tig Streptococcus pneumoniae R6 trigger factor NP_357956.1 359944 D 171101 CDS NP_357957.1 15902407 934058 complement(361275..363641) 1 NC_003098.1 exonuclease V 363641 recD 934058 recD Streptococcus pneumoniae R6 exonuclease V NP_357957.1 361275 R 171101 CDS NP_357958.1 15902408 934640 complement(363875..364489) 1 NC_003098.1 signal peptidase I 364489 spi 934640 spi Streptococcus pneumoniae R6 signal peptidase I NP_357958.1 363875 R 171101 CDS NP_357959.1 15902409 933085 complement(364501..365373) 1 NC_003098.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII 365373 rnhB 933085 rnhB Streptococcus pneumoniae R6 ribonuclease HIII NP_357959.1 364501 R 171101 CDS NP_357960.1 15902410 934835 365451..365762 1 NC_003098.1 hypothetical protein 365762 934835 spr0366 Streptococcus pneumoniae R6 hypothetical protein NP_357960.1 365451 D 171101 CDS NP_357961.1 15902411 934646 365759..366307 1 NC_003098.1 hypothetical protein 366307 934646 spr0367 Streptococcus pneumoniae R6 hypothetical protein NP_357961.1 365759 D 171101 CDS NP_357962.1 15902412 934644 366411..368747 1 NC_003098.1 MutS2 family protein 368747 mutS2 934644 mutS2 Streptococcus pneumoniae R6 MutS2 family protein NP_357962.1 366411 D 171101 CDS NP_357963.1 15902413 934641 369089..370411 1 NC_003098.1 sodium:alanine symporter family protein 370411 dagA 934641 dagA Streptococcus pneumoniae R6 sodium:alanine symporter family protein NP_357963.1 369089 D 171101 CDS NP_357964.1 15902414 934649 370629..371177 1 NC_003098.1 hypothetical protein 371177 mip 934649 mip Streptococcus pneumoniae R6 hypothetical protein NP_357964.1 370629 D 171101 CDS NP_357965.1 15902415 934642 371275..372186 1 NC_003098.1 exfoliative toxin 372186 shetA 934642 shetA Streptococcus pneumoniae R6 exfoliative toxin NP_357965.1 371275 D 171101 CDS NP_357966.2 161410754 934643 complement(372211..373485) 1 NC_003098.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 373485 serS 934643 serS Streptococcus pneumoniae R6 seryl-tRNA synthetase NP_357966.2 372211 R 171101 CDS NP_357967.1 15902417 934651 complement(373698..374069) 1 NC_003098.1 hypothetical protein 374069 934651 spr0373 Streptococcus pneumoniae R6 hypothetical protein NP_357967.1 373698 R 171101 CDS NP_357968.1 15902418 934653 complement(374072..375436) 1 NC_003098.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase 375436 lysC 934653 lysC Streptococcus pneumoniae R6 aspartate kinase NP_357968.1 374072 R 171101 CDS NP_357969.1 15902419 934663 375761..376546 1 NC_003098.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 376546 phaB 934663 phaB Streptococcus pneumoniae R6 enoyl-CoA hydratase NP_357969.1 375761 D 171101 CDS NP_357970.1 15902420 934658 376640..377074 1 NC_003098.1 Probable transcriptional regulator; hypothetical protein 377074 934658 spr0376 Streptococcus pneumoniae R6 hypothetical protein NP_357970.1 376640 D 171101 CDS NP_357971.1 15902421 934655 377074..378048 1 NC_003098.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 378048 fabH 934655 fabH Streptococcus pneumoniae R6 3-oxoacyl-ACP synthase NP_357971.1 377074 D 171101 CDS NP_357972.1 15902422 934673 378108..378332 1 NC_003098.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 378332 acpP 934673 acpP Streptococcus pneumoniae R6 acyl carrier protein NP_357972.1 378108 D 171101 CDS NP_357973.1 15902423 934670 378451..379425 1 NC_003098.1 enoyl-acyl carrier protein(ACP) reductase 379425 fabK 934670 fabK Streptococcus pneumoniae R6 enoyl-acyl carrier protein(ACP) reductase NP_357973.1 378451 D 171101 CDS NP_357974.1 15902424 934657 379418..380338 1 NC_003098.1 ACP S-malonyltransferase 380338 fabD 934657 fabD Streptococcus pneumoniae R6 ACP S-malonyltransferase NP_357974.1 379418 D 171101 CDS NP_357975.1 15902425 934672 380372..381103 1 NC_003098.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 381103 fabG 934672 fabG Streptococcus pneumoniae R6 3-ketoacyl-ACP reductase NP_357975.1 380372 D 171101 CDS NP_357976.1 15902426 934660 381116..382360 1 NC_003098.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 382360 fabF 934660 fabF Streptococcus pneumoniae R6 3-oxoacyl-ACP synthase NP_357976.1 381116 D 171101 CDS NP_357977.1 15902427 934665 382363..382848 1 NC_003098.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 382848 accB 934665 accB Streptococcus pneumoniae R6 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit NP_357977.1 382363 D 171101 CDS NP_357978.1 15902428 934674 382845..383267 1 NC_003098.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 383267 fabZ 934674 fabZ Streptococcus pneumoniae R6 (3R)-hydroxymyristoyl-ACP dehydratase NP_357978.1 382845 D 171101 CDS NP_357979.1 15902429 934681 383279..384646 1 NC_003098.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 384646 accC 934681 accC Streptococcus pneumoniae R6 acetyl-CoA carboxylase biotin carboxylase subunit NP_357979.1 383279 D 171101 CDS NP_357980.1 15902430 934669 384683..385549 1 NC_003098.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 385549 accD 934669 accD Streptococcus pneumoniae R6 acetyl-CoA carboxylase subunit beta NP_357980.1 384683 D 171101 CDS NP_357981.1 15902431 934683 385546..386313 1 NC_003098.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha 386313 accA 934683 accA Streptococcus pneumoniae R6 acetyl-CoA carboxylase subunit alpha NP_357981.1 385546 D 171101 CDS NP_357984.1 15902434 934688 complement(387424..387864) 1 NC_003098.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 387864 nusB 934688 nusB Streptococcus pneumoniae R6 transcription antitermination protein NusB NP_357984.1 387424 R 171101 CDS NP_357985.1 15902435 934678 complement(387839..388228) 1 NC_003098.1 hypothetical protein 388228 934678 spr0391 Streptococcus pneumoniae R6 hypothetical protein NP_357985.1 387839 R 171101 CDS NP_357986.1 15902436 934680 complement(388250..388810) 1 NC_003098.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 388810 efp 934680 efp Streptococcus pneumoniae R6 elongation factor P NP_357986.1 388250 R 171101 CDS NP_357987.1 15902437 934697 complement(388939..390381) 1 NC_003098.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 390381 gatB 934697 gatB Streptococcus pneumoniae R6 aspartyl/glutamyl-tRNA amidotransferase subunit B NP_357987.1 388939 R 171101 CDS NP_357988.1 15902438 934695 complement(390381..391847) 1 NC_003098.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 391847 gatA 934695 gatA Streptococcus pneumoniae R6 aspartyl/glutamyl-tRNA amidotransferase subunit A NP_357988.1 390381 R 171101 CDS NP_357989.1 15902439 934685 complement(391847..392149) 1 NC_003098.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 392149 gatC 934685 gatC Streptococcus pneumoniae R6 aspartyl/glutamyl-tRNA amidotransferase subunit C NP_357989.1 391847 R 171101 CDS NP_357990.1 15902440 934704 392362..393906 1 NC_003098.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 393906 prfC 934704 prfC Streptococcus pneumoniae R6 peptide chain release factor 3 NP_357990.1 392362 D 171101 CDS NP_357991.1 15902441 934691 394175..394660 1 NC_003098.1 hypothetical protein 394660 934691 spr0397 Streptococcus pneumoniae R6 hypothetical protein NP_357991.1 394175 D 171101 CDS NP_357992.1 15902442 934689 394776..394964 1 NC_003098.1 required for 70S ribosome assembly; 50S ribosomal protein L28 394964 rpmB 934689 rpmB Streptococcus pneumoniae R6 50S ribosomal protein L28 NP_357992.1 394776 D 171101 CDS NP_357993.1 15902443 934702 395121..395486 1 NC_003098.1 hypothetical protein 395486 asp23 934702 asp23 Streptococcus pneumoniae R6 hypothetical protein NP_357993.1 395121 D 171101 CDS NP_357994.1 15902444 934693 395489..397156 1 NC_003098.1 hypothetical protein 397156 934693 spr0400 Streptococcus pneumoniae R6 hypothetical protein NP_357994.1 395489 D 171101 CDS NP_357995.1 15902445 934698 397357..399057 1 NC_003098.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit 399057 ilvB 934698 ilvB Streptococcus pneumoniae R6 acetolactate synthase catalytic subunit NP_357995.1 397357 D 171101 CDS NP_357996.1 15902446 934725 399026..399526 1 NC_003098.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 399526 ilvH 934725 ilvH Streptococcus pneumoniae R6 acetolactate synthase 3 regulatory subunit NP_357996.1 399026 D 171101 CDS NP_357997.1 15902447 934707 399592..400614 1 NC_003098.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 400614 ilvC 934707 ilvC Streptococcus pneumoniae R6 ketol-acid reductoisomerase NP_357997.1 399592 D 171101 CDS NP_357999.1 15902449 934721 401195..401551 1 NC_003098.1 hypothetical protein 401551 934721 spr0405 Streptococcus pneumoniae R6 hypothetical protein NP_357999.1 401195 D 171101 CDS NP_358000.1 15902450 934708 401601..402851 1 NC_003098.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 402851 ilvA 934708 ilvA Streptococcus pneumoniae R6 threonine dehydratase NP_358000.1 401601 D 171101 CDS NP_358001.1 15902451 934719 403586..403801 1 NC_003098.1 hypothetical protein 403801 934719 spr0407 Streptococcus pneumoniae R6 hypothetical protein NP_358001.1 403586 D 171101 CDS NP_358002.1 15902452 934709 complement(403910..404650) 1 NC_003098.1 amino acid ABC transporter ATP-binding protein 404650 glnQ 934709 glnQ Streptococcus pneumoniae R6 amino acid ABC transporter ATP-binding protein NP_358002.1 403910 R 171101 CDS NP_358003.2 555247341 934710 complement(404650..406215) 1 NC_003098.1 glutamine ABC transporter substrate-binding protein 406215 glnH 934710 glnH Streptococcus pneumoniae R6 glutamine ABC transporter substrate-binding protein NP_358003.2 404650 R 171101 CDS NP_358004.1 15902454 934724 406350..408242 1 NC_003098.1 hypothetical protein 408242 934724 spr0410 Streptococcus pneumoniae R6 hypothetical protein NP_358004.1 406350 D 171101 CDS NP_358007.1 15902457 934740 409666..410511 1 NC_003098.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 410511 uppP 934740 uppP Streptococcus pneumoniae R6 undecaprenyl pyrophosphate phosphatase NP_358007.1 409666 D 171101 CDS NP_358008.1 15902458 934718 complement(410657..411727) 1 NC_003098.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 411727 dinP 934718 dinP Streptococcus pneumoniae R6 DNA polymerase IV NP_358008.1 410657 R 171101 CDS NP_358009.1 15902459 934727 412113..414437 1 NC_003098.1 formate acetyltransferase 414437 pfl 934727 pfl Streptococcus pneumoniae R6 formate acetyltransferase NP_358009.1 412113 D 171101 CDS NP_358010.1 15902460 934736 complement(414804..415151) 1 NC_003098.1 hypothetical protein 415151 934736 spr0416 Streptococcus pneumoniae R6 hypothetical protein NP_358010.1 414804 R 171101 CDS NP_358011.1 15902461 934731 complement(415349..415633) 1 NC_003098.1 hypothetical protein 415633 934731 spr0417 Streptococcus pneumoniae R6 hypothetical protein NP_358011.1 415349 R 171101 CDS NP_358014.1 15902464 934739 complement(417068..418291) 1 NC_003098.1 ROK family protein 418291 xylR 934739 xylR Streptococcus pneumoniae R6 ROK family protein NP_358014.1 417068 R 171101 CDS NP_358015.1 15902465 934738 418456..419781 1 NC_003098.1 PTS system cellobiose-specific transporter subunit IIC 419781 PTS-EII 934738 PTS-EII Streptococcus pneumoniae R6 PTS system cellobiose-specific transporter subunit IIC NP_358015.1 418456 D 171101 CDS NP_358016.1 15902466 934749 419729..421669 1 NC_003098.1 hypothetical protein 421669 934749 spr0422 Streptococcus pneumoniae R6 hypothetical protein NP_358016.1 419729 D 171101 CDS NP_358017.1 15902467 934748 421837..422181 1 NC_003098.1 PTS system lactose-specific transporter subunit IIA 422181 PTS-EII 934748 PTS-EII Streptococcus pneumoniae R6 PTS system lactose-specific transporter subunit IIA NP_358017.1 421837 D 171101 CDS NP_358018.1 15902468 934741 422191..423603 1 NC_003098.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 423603 lacG 934741 lacG Streptococcus pneumoniae R6 6-phospho-beta-galactosidase NP_358018.1 422191 D 171101 CDS NP_358019.1 15902469 934754 423672..425351 1 NC_003098.1 PTS system sugar-specific transporter subunit EII 425351 PTS-EII 934754 PTS-EII Streptococcus pneumoniae R6 PTS system sugar-specific transporter subunit EII NP_358019.1 423672 D 171101 CDS NP_358020.1 15902470 934745 complement(425479..426918) 1 NC_003098.1 Trk transporter membrane-spanning protein 426918 trkH 934745 trkH Streptococcus pneumoniae R6 Trk transporter membrane-spanning protein NP_358020.1 425479 R 171101 CDS NP_358021.1 15902471 934746 complement(426922..428271) 1 NC_003098.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 428271 trkA 934746 trkA Streptococcus pneumoniae R6 potassium transporter peripheral membrane component NP_358021.1 426922 R 171101 CDS NP_358022.1 15902472 934755 428433..429308 1 NC_003098.1 hypothetical protein 429308 934755 spr0428 Streptococcus pneumoniae R6 hypothetical protein NP_358022.1 428433 D 171101 CDS NP_358023.1 15902473 934767 429323..429871 1 NC_003098.1 hypothetical protein 429871 934767 spr0429 Streptococcus pneumoniae R6 hypothetical protein NP_358023.1 429323 D 171101 CDS NP_358024.1 15902474 934771 430192..431874 1 NC_003098.1 ABC transporter ATP-binding protein 431874 ABC-NBD 934771 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358024.1 430192 D 171101 CDS NP_358025.1 15902475 934760 431859..432689 1 NC_003098.1 hypothetical protein 432689 ABC-MSD 934760 ABC-MSD Streptococcus pneumoniae R6 hypothetical protein NP_358025.1 431859 D 171101 CDS NP_358026.1 15902476 934758 432843..433385 1 NC_003098.1 rRNA methylase 433385 cspR 934758 cspR Streptococcus pneumoniae R6 rRNA methylase NP_358026.1 432843 D 171101 CDS NP_358027.1 15902477 934779 433829..434407 1 NC_003098.1 hypothetical protein 434407 934779 spr0433 Streptococcus pneumoniae R6 hypothetical protein NP_358027.1 433829 D 171101 CDS NP_358028.1 15902478 934762 434397..435047 1 NC_003098.1 Probable phosphatidic acid phosphatase; PAP2 family protein 435047 934762 spr0434 Streptococcus pneumoniae R6 PAP2 family protein NP_358028.1 434397 D 171101 CDS NP_358029.1 15902479 934768 435075..435464 1 NC_003098.1 hypothetical protein 435464 934768 spr0435 Streptococcus pneumoniae R6 hypothetical protein NP_358029.1 435075 D 171101 CDS NP_358030.1 15902480 934769 435469..435918 1 NC_003098.1 hypothetical protein 435918 934769 spr0436 Streptococcus pneumoniae R6 hypothetical protein NP_358030.1 435469 D 171101 CDS NP_358031.2 161410753 934765 436046..436633 1 NC_003098.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 436633 rpoE 934765 rpoE Streptococcus pneumoniae R6 DNA-directed RNA polymerase subunit delta NP_358031.2 436046 D 171101 CDS NP_358032.1 15902482 934794 437023..438630 1 NC_003098.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 438630 pyrG 934794 pyrG Streptococcus pneumoniae R6 CTP synthetase NP_358032.1 437023 D 171101 CDS NP_358033.1 15902483 934792 complement(439189..440820) 1 NC_003098.1 Probable integral membrane protein; hypothetical protein 440820 934792 spr0439 Streptococcus pneumoniae R6 hypothetical protein NP_358033.1 439189 R 171101 CDS NP_358034.1 15902484 934776 441113..446092 1 NC_003098.1 Similar to endo-beta-N-acetylglucosaminidase; endo-beta-N-acetylglucosaminidase 446092 934776 spr0440 Streptococcus pneumoniae R6 endo-beta-N-acetylglucosaminidase NP_358034.1 441113 D 171101 CDS NP_358035.1 15902485 934773 446182..447378 1 NC_003098.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 447378 pgk 934773 pgk Streptococcus pneumoniae R6 phosphoglycerate kinase NP_358035.1 446182 D 171101 CDS NP_358036.1 15902486 934790 447514..448041 1 NC_003098.1 hypothetical protein 448041 934790 spr0442 Streptococcus pneumoniae R6 hypothetical protein NP_358036.1 447514 D 171101 CDS NP_358037.1 15902487 934781 448118..448474 1 NC_003098.1 transcriptional repressor of the glutamine synthetase gene 448474 glnR 934781 glnR Streptococcus pneumoniae R6 transcriptional repressor of the glutamine synthetase gene NP_358037.1 448118 D 171101 CDS NP_358038.1 15902488 934783 448511..449857 1 NC_003098.1 glutamine synthetase, type I 449857 glnA 934783 glnA Streptococcus pneumoniae R6 glutamine synthetase, type I NP_358038.1 448511 D 171101 CDS NP_358039.1 15902489 934784 450637..451917 1 NC_003098.1 type I restriction-modification system S subunit 451917 hsdS 934784 hsdS Streptococcus pneumoniae R6 type I restriction-modification system S subunit NP_358039.1 450637 D 171101 CDS NP_358040.1 15902490 934789 complement(451871..452470) 1 NC_003098.1 type I restriction-modification system S subunit 452470 hsdS 934789 hsdS Streptococcus pneumoniae R6 type I restriction-modification system S subunit NP_358040.1 451871 R 171101 CDS NP_358041.1 15902491 934813 complement(452481..453278) 1 NC_003098.1 integrase/recombinase 453278 xerD 934813 xerD Streptococcus pneumoniae R6 integrase/recombinase NP_358041.1 452481 R 171101 CDS NP_358042.1 15902492 934798 complement(453335..454903) 1 NC_003098.1 type I restriction-modification system S subunit 454903 hsdS 934798 hsdS Streptococcus pneumoniae R6 type I restriction-modification system S subunit NP_358042.1 453335 R 171101 CDS NP_358043.1 15902493 934799 complement(454903..456366) 1 NC_003098.1 type I restriction-modification system M subunit 456366 hsdM 934799 hsdM Streptococcus pneumoniae R6 type I restriction-modification system M subunit NP_358043.1 454903 R 171101 CDS NP_358044.1 15902494 934824 complement(456379..458712) 1 NC_003098.1 type I restriction-modification system R subunit 458712 hsdR 934824 hsdR Streptococcus pneumoniae R6 type I restriction-modification system R subunit NP_358044.1 456379 R 171101 CDS NP_358045.1 15902495 934800 459085..459285 1 NC_003098.1 hypothetical protein 459285 934800 spr0451 Streptococcus pneumoniae R6 hypothetical protein NP_358045.1 459085 D 171101 CDS NP_358046.1 15902496 934803 459320..459829 1 NC_003098.1 hypothetical protein 459829 934803 spr0452 Streptococcus pneumoniae R6 hypothetical protein NP_358046.1 459320 D 171101 CDS NP_358047.1 15902497 934815 459960..461027 1 NC_003098.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 461027 hrcA 934815 hrcA Streptococcus pneumoniae R6 heat-inducible transcription repressor NP_358047.1 459960 D 171101 CDS NP_358048.1 15902498 934809 461030..461578 1 NC_003098.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 461578 grpE 934809 grpE Streptococcus pneumoniae R6 heat shock protein GrpE NP_358048.1 461030 D 171101 CDS NP_358049.1 15902499 934811 462058..463881 1 NC_003098.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 463881 dnaK 934811 dnaK Streptococcus pneumoniae R6 molecular chaperone DnaK NP_358049.1 462058 D 171101 CDS NP_358050.1 15902500 934826 464641..465759 1 NC_003098.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 465759 dnaJ 934826 dnaJ Streptococcus pneumoniae R6 molecular chaperone DnaJ NP_358050.1 464641 D 171101 CDS NP_358051.1 15902501 934812 complement(466094..466381) 1 NC_003098.1 hypothetical protein 466381 934812 spr0457 Streptococcus pneumoniae R6 hypothetical protein NP_358051.1 466094 R 171101 CDS NP_358052.1 15902502 934830 complement(466391..466801) 1 NC_003098.1 HIT-like protein; hypothetical protein 466801 934830 spr0458 Streptococcus pneumoniae R6 hypothetical protein NP_358052.1 466391 R 171101 CDS NP_358053.1 15902503 934822 466869..467600 1 NC_003098.1 ABC transporter ATP-binding protein 467600 ABC-NBD 934822 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358053.1 466869 D 171101 CDS NP_358054.1 15902504 934832 467597..468646 1 NC_003098.1 ABC transporter permease 468646 ABC-MSP 934832 ABC-MSP Streptococcus pneumoniae R6 ABC transporter permease NP_358054.1 467597 D 171101 CDS NP_358055.1 15902505 934827 complement(468814..469143) 1 NC_003098.1 hypothetical protein 469143 blpT 934827 blpT Streptococcus pneumoniae R6 hypothetical protein NP_358055.1 468814 R 171101 CDS NP_358056.1 15902506 934833 469419..469757 1 NC_003098.1 regulatory protein BlpS 469757 blpS 934833 blpS Streptococcus pneumoniae R6 regulatory protein BlpS NP_358056.1 469419 D 171101 CDS NP_358057.1 15902507 933176 469762..470499 1 NC_003098.1 response regulator BlpR 470499 rr13 933176 rr13 Streptococcus pneumoniae R6 response regulator BlpR NP_358057.1 469762 D 171101 CDS NP_358058.1 15902508 933263 470513..471853 1 NC_003098.1 histidine kinase 471853 hk13 933263 hk13 Streptococcus pneumoniae R6 histidine kinase NP_358058.1 470513 D 171101 CDS NP_358059.1 15902509 933743 complement(471895..472050) 1 NC_003098.1 peptide pheromone BlpC 472050 ip 933743 ip Streptococcus pneumoniae R6 peptide pheromone BlpC NP_358059.1 471895 R 171101 CDS NP_358064.1 15902514 933339 475926..476159 1 NC_003098.1 hypothetical protein 476159 933339 spr0470 Streptococcus pneumoniae R6 hypothetical protein NP_358064.1 475926 D 171101 CDS NP_358065.1 15902515 932909 476175..476354 1 NC_003098.1 hypothetical protein 476354 932909 spr0471 Streptococcus pneumoniae R6 hypothetical protein NP_358065.1 476175 D 171101 CDS NP_358066.1 15902516 933857 476191..476880 1 NC_003098.1 immunity protein BlpY 476880 blpY 933857 blpY Streptococcus pneumoniae R6 immunity protein BlpY NP_358066.1 476191 D 171101 CDS NP_358067.1 15902517 933043 476922..477155 1 NC_003098.1 hypothetical protein 477155 blpZ 933043 blpZ Streptococcus pneumoniae R6 hypothetical protein NP_358067.1 476922 D 171101 CDS NP_358068.1 15902518 933556 477306..477917 1 NC_003098.1 ABC transporter ATP-binding protein 477917 pncP 933556 pncP Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358068.1 477306 D 171101 CDS NP_358069.1 15902519 933194 478078..478872 1 NC_003098.1 hypothetical protein 478872 933194 spr0475 Streptococcus pneumoniae R6 hypothetical protein NP_358069.1 478078 D 171101 CDS NP_358070.1 15902520 933048 478869..479504 1 NC_003098.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 479504 trmB 933048 trmB Streptococcus pneumoniae R6 tRNA (guanine-N(7)-)-methyltransferase NP_358070.1 478869 D 171101 CDS NP_358071.1 15902521 933553 479630..480109 1 NC_003098.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 480109 933553 spr0477 Streptococcus pneumoniae R6 hypothetical protein NP_358071.1 479630 D 171101 CDS NP_358072.1 15902522 933557 480153..481289 1 NC_003098.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 481289 nusA 933557 nusA Streptococcus pneumoniae R6 transcription elongation factor NusA NP_358072.1 480153 D 171101 CDS NP_358073.1 15902523 933559 481311..481604 1 NC_003098.1 hypothetical protein 481604 933559 spr0479 Streptococcus pneumoniae R6 hypothetical protein NP_358073.1 481311 D 171101 CDS NP_358074.1 15902524 933550 481597..481896 1 NC_003098.1 Probable ribosomal protein; hypothetical protein 481896 933550 spr0480 Streptococcus pneumoniae R6 hypothetical protein NP_358074.1 481597 D 171101 CDS NP_358075.1 15902525 933555 481913..484705 1 NC_003098.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 484705 infB 933555 infB Streptococcus pneumoniae R6 translation initiation factor IF-2 NP_358075.1 481913 D 171101 CDS NP_358076.1 15902526 933554 484929..485306 1 NC_003098.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 485306 rbfA 933554 rbfA Streptococcus pneumoniae R6 ribosome-binding factor A NP_358076.1 484929 D 171101 CDS NP_358077.1 15902527 933552 485549..486364 1 NC_003098.1 hypothetical protein 486364 933552 spr0483 Streptococcus pneumoniae R6 hypothetical protein NP_358077.1 485549 D 171101 CDS NP_358078.1 15902528 933551 486366..486548 1 NC_003098.1 hypothetical protein 486548 933551 spr0484 Streptococcus pneumoniae R6 hypothetical protein NP_358078.1 486366 D 171101 CDS NP_358079.1 15902529 933549 486986..487231 1 NC_003098.1 hypothetical protein 487231 933549 spr0485 Streptococcus pneumoniae R6 hypothetical protein NP_358079.1 486986 D 171101 CDS NP_358080.1 15902530 933548 487231..488565 1 NC_003098.1 hypothetical protein 488565 933548 spr0486 Streptococcus pneumoniae R6 hypothetical protein NP_358080.1 487231 D 171101 CDS NP_358081.1 15902531 933542 488575..488829 1 NC_003098.1 hypothetical protein 488829 933542 spr0487 Streptococcus pneumoniae R6 hypothetical protein NP_358081.1 488575 D 171101 CDS NP_358082.1 15902532 933547 488925..489320 1 NC_003098.1 hypothetical protein 489320 933547 spr0488 Streptococcus pneumoniae R6 hypothetical protein NP_358082.1 488925 D 171101 CDS NP_358083.1 15902533 933546 489732..490181 1 NC_003098.1 hypothetical protein 490181 933546 spr0489 Streptococcus pneumoniae R6 hypothetical protein NP_358083.1 489732 D 171101 CDS NP_358084.1 15902534 933539 490168..490725 1 NC_003098.1 Probable acetyl transferase; hypothetical protein 490725 933539 spr0490 Streptococcus pneumoniae R6 hypothetical protein NP_358084.1 490168 D 171101 CDS NP_358085.1 15902535 933545 490727..491689 1 NC_003098.1 hypothetical protein 491689 933545 spr0491 Streptococcus pneumoniae R6 hypothetical protein NP_358085.1 490727 D 171101 CDS NP_358086.1 15902536 933544 491701..494352 1 NC_003098.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 494352 valS 933544 valS Streptococcus pneumoniae R6 valyl-tRNA synthetase NP_358086.1 491701 D 171101 CDS NP_358087.1 15902537 933536 494407..495177 1 NC_003098.1 hypothetical protein 495177 933536 spr0493 Streptococcus pneumoniae R6 hypothetical protein NP_358087.1 494407 D 171101 CDS NP_358088.1 15902538 933541 495460..496263 1 NC_003098.1 cell filamentation protein Fic-related protein 496263 933541 spr0494 Streptococcus pneumoniae R6 cell filamentation protein Fic-related protein NP_358088.1 495460 D 171101 CDS NP_358093.1 15902543 933531 497816..498883 1 NC_003098.1 hypothetical protein 498883 933531 spr0499 Streptococcus pneumoniae R6 hypothetical protein NP_358093.1 497816 D 171101 CDS NP_358098.1 15902548 933525 500872..501711 1 NC_003098.1 BglG family transcriptional antiterminator 501711 licT 933525 licT Streptococcus pneumoniae R6 BglG family transcriptional antiterminator NP_358098.1 500872 D 171101 CDS NP_358099.1 15902549 933530 501729..503567 1 NC_003098.1 PTS system beta-glucosides-specific transporter subunit IIABC 503567 PTS-EII 933530 PTS-EII Streptococcus pneumoniae R6 PTS system beta-glucosides-specific transporter subunit IIABC NP_358099.1 501729 D 171101 CDS NP_358100.1 15902550 933529 503580..504995 1 NC_003098.1 6-phospho-beta-glucosidase 504995 bglH 933529 bglH Streptococcus pneumoniae R6 6-phospho-beta-glucosidase NP_358100.1 503580 D 171101 CDS NP_358101.2 161410752 933527 505587..506633 1 NC_003098.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 506633 pheS 933527 pheS Streptococcus pneumoniae R6 phenylalanyl-tRNA synthetase subunit alpha NP_358101.2 505587 D 171101 CDS NP_358102.1 15902552 933526 506633..507142 1 NC_003098.1 Probable transcriptional regulator; hypothetical protein 507142 933526 spr0508 Streptococcus pneumoniae R6 hypothetical protein NP_358102.1 506633 D 171101 CDS NP_358103.1 15902553 933519 507219..509621 1 NC_003098.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 509621 pheT 933519 pheT Streptococcus pneumoniae R6 phenylalanyl-tRNA synthetase subunit beta NP_358103.1 507219 D 171101 CDS NP_358104.1 15902554 933523 complement(509689..510690) 1 NC_003098.1 hypothetical protein 510690 933523 spr0510 Streptococcus pneumoniae R6 hypothetical protein NP_358104.1 509689 R 171101 CDS NP_358107.1 15902557 933521 511419..511685 1 NC_003098.1 hypothetical protein 511685 933521 spr0513 Streptococcus pneumoniae R6 hypothetical protein NP_358107.1 511419 D 171101 CDS NP_358108.1 15902558 933520 511802..514195 1 NC_003098.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 514195 metE 933520 metE Streptococcus pneumoniae R6 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase NP_358108.1 511802 D 171101 CDS NP_358109.1 15902559 933513 514259..515125 1 NC_003098.1 5,10-methylenetetrahydrofolate reductase 515125 metF 933513 metF Streptococcus pneumoniae R6 5,10-methylenetetrahydrofolate reductase NP_358109.1 514259 D 171101 CDS NP_358110.1 15902560 933518 515696..518023 1 NC_003098.1 polynucleotide phosphorylase 518023 pnpA 933518 pnpA Streptococcus pneumoniae R6 polynucleotide phosphorylase NP_358110.1 515696 D 171101 CDS NP_358111.1 15902561 933517 518039..518656 1 NC_003098.1 serine acetyltransferase 518656 cysE 933517 cysE Streptococcus pneumoniae R6 serine acetyltransferase NP_358111.1 518039 D 171101 CDS NP_358112.1 15902562 933510 518668..519552 1 NC_003098.1 hypothetical protein 519552 933510 spr0518 Streptococcus pneumoniae R6 hypothetical protein NP_358112.1 518668 D 171101 CDS NP_358113.1 15902563 933515 519634..520977 1 NC_003098.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 520977 cysS 933515 cysS Streptococcus pneumoniae R6 cysteinyl-tRNA synthetase NP_358113.1 519634 D 171101 CDS NP_358114.1 15902564 933514 520970..521356 1 NC_003098.1 hypothetical protein 521356 933514 spr0520 Streptococcus pneumoniae R6 hypothetical protein NP_358114.1 520970 D 171101 CDS NP_358115.1 15902565 933507 521360..522244 1 NC_003098.1 Leucine rich protein; hypothetical protein 522244 933507 spr0521 Streptococcus pneumoniae R6 hypothetical protein NP_358115.1 521360 D 171101 CDS NP_358118.1 15902568 933509 523650..524927 1 NC_003098.1 peptide ABC transporter permease 524927 vex1 933509 vex1 Streptococcus pneumoniae R6 peptide ABC transporter permease NP_358118.1 523650 D 171101 CDS NP_358119.1 15902569 933508 524940..525587 1 NC_003098.1 ABC transporter ATP-binding protein 525587 vex2 933508 vex2 Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358119.1 524940 D 171101 CDS NP_358120.1 15902570 933495 525639..527018 1 NC_003098.1 peptide ABC transporter permease 527018 vex3 933495 vex3 Streptococcus pneumoniae R6 peptide ABC transporter permease NP_358120.1 525639 D 171101 CDS NP_358122.1 15902572 933502 527330..527986 1 NC_003098.1 response regulator VncR 527986 vncR 933502 vncR Streptococcus pneumoniae R6 response regulator VncR NP_358122.1 527330 D 171101 CDS NP_358123.1 15902573 933480 527983..529311 1 NC_003098.1 histidine kinase VncS 529311 vncS 933480 vncS Streptococcus pneumoniae R6 histidine kinase VncS NP_358123.1 527983 D 171101 CDS NP_358124.1 15902574 933499 529452..530333 1 NC_003098.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 530333 fba 933499 fba Streptococcus pneumoniae R6 fructose-bisphosphate aldolase NP_358124.1 529452 D 171101 CDS NP_358125.1 15902575 933496 complement(530654..531856) 1 NC_003098.1 Probable oxidoreductase; oxidoreductase 531856 933496 spr0531 Streptococcus pneumoniae R6 oxidoreductase NP_358125.1 530654 R 171101 CDS NP_358126.1 15902576 933482 complement(532102..532761) 1 NC_003098.1 amino acid ABC transporter permease 532761 glnP 933482 glnP Streptococcus pneumoniae R6 amino acid ABC transporter permease NP_358126.1 532102 R 171101 CDS NP_358127.1 15902577 933485 complement(532771..533448) 1 NC_003098.1 amino acid ABC transporter permease 533448 glnP 933485 glnP Streptococcus pneumoniae R6 amino acid ABC transporter permease NP_358127.1 532771 R 171101 CDS NP_358128.1 15902578 933401 complement(533461..534255) 1 NC_003098.1 amino acid ABC transporter amino acid-binding protein 534255 glnH 933401 glnH Streptococcus pneumoniae R6 amino acid ABC transporter amino acid-binding protein NP_358128.1 533461 R 171101 CDS NP_358131.1 15902581 933422 535289..537523 1 NC_003098.1 single-stranded-DNA-specific exonuclease RecJ 537523 recJ 933422 recJ Streptococcus pneumoniae R6 single-stranded-DNA-specific exonuclease RecJ NP_358131.1 535289 D 171101 CDS NP_358132.1 15902582 933405 537698..539359 1 NC_003098.1 metallo-beta-lactamase superfamily protein 539359 933405 spr0538 Streptococcus pneumoniae R6 metallo-beta-lactamase superfamily protein NP_358132.1 537698 D 171101 CDS NP_358133.1 15902583 933384 539428..540207 1 NC_003098.1 tributyrin esterase 540207 estA 933384 estA Streptococcus pneumoniae R6 tributyrin esterase NP_358133.1 539428 D 171101 CDS NP_358134.1 15902584 933395 540319..541539 1 NC_003098.1 serine/alanine adding enzyme 541539 murM 933395 murM Streptococcus pneumoniae R6 serine/alanine adding enzyme NP_358134.1 540319 D 171101 CDS NP_358135.1 15902585 933396 541544..542776 1 NC_003098.1 beta-lactam resistance factor 542776 murN 933396 murN Streptococcus pneumoniae R6 beta-lactam resistance factor NP_358135.1 541544 D 171101 CDS NP_358136.1 15902586 933380 542892..543551 1 NC_003098.1 hypothetical protein 543551 933380 spr0542 Streptococcus pneumoniae R6 hypothetical protein NP_358136.1 542892 D 171101 CDS NP_358137.1 15902587 933390 543591..545435 1 NC_003098.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 545435 uvrC 933390 uvrC Streptococcus pneumoniae R6 excinuclease ABC subunit C NP_358137.1 543591 D 171101 CDS NP_358138.1 15902588 933388 545425..546258 1 NC_003098.1 hypothetical protein 546258 933388 spr0544 Streptococcus pneumoniae R6 hypothetical protein NP_358138.1 545425 D 171101 CDS NP_358139.1 15902589 933383 complement(546440..547255) 1 NC_003098.1 glutamine ABC transporter substrate-binding protein 547255 ABC-SBP 933383 ABC-SBP Streptococcus pneumoniae R6 glutamine ABC transporter substrate-binding protein NP_358139.1 546440 R 171101 CDS NP_358140.1 15902590 933381 547411..548016 1 NC_003098.1 nitroreductase 548016 nrd 933381 nrd Streptococcus pneumoniae R6 nitroreductase NP_358140.1 547411 D 171101 CDS NP_358141.1 15902591 933367 548029..549429 1 NC_003098.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 549429 pepV 933367 pepV Streptococcus pneumoniae R6 dipeptidase PepV NP_358141.1 548029 D 171101 CDS NP_358142.1 15902592 933378 549483..550061 1 NC_003098.1 hypothetical protein 550061 933378 spr0548 Streptococcus pneumoniae R6 hypothetical protein NP_358142.1 549483 D 171101 CDS NP_358145.1 15902595 933369 550668..552008 1 NC_003098.1 branched chain amino acid ABC transporter carrier protein 552008 brnQ 933369 brnQ Streptococcus pneumoniae R6 branched chain amino acid ABC transporter carrier protein NP_358145.1 550668 D 171101 CDS NP_358146.1 15902596 933366 552212..553249 1 NC_003098.1 hypothetical protein 553249 933366 spr0552 Streptococcus pneumoniae R6 hypothetical protein NP_358146.1 552212 D 171101 CDS NP_358147.1 15902597 933365 553218..553721 1 NC_003098.1 HIT family protein 553721 933365 spr0553 Streptococcus pneumoniae R6 HIT family protein NP_358147.1 553218 D 171101 CDS NP_358148.1 15902598 933353 553724..554440 1 NC_003098.1 carboxypeptidase; hypothetical protein 554440 933353 spr0554 Streptococcus pneumoniae R6 hypothetical protein NP_358148.1 553724 D 171101 CDS NP_358149.1 15902599 933360 554749..555174 1 NC_003098.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 555174 rplK 933360 rplK Streptococcus pneumoniae R6 50S ribosomal protein L11 NP_358149.1 554749 D 171101 CDS NP_358150.1 15902600 933347 555382..556071 1 NC_003098.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 556071 rplA 933347 rplA Streptococcus pneumoniae R6 50S ribosomal protein L1 NP_358150.1 555382 D 171101 CDS NP_358151.1 15902601 933350 558589..559581 1 NC_003098.1 ABC transporter ATP-binding protein 559581 ABC-NBD 933350 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358151.1 558589 D 171101 CDS NP_358152.1 15902602 933348 559541..560401 1 NC_003098.1 hypothetical protein 560401 933348 spr0558 Streptococcus pneumoniae R6 hypothetical protein NP_358152.1 559541 D 171101 CDS NP_358153.1 15902603 933329 560403..561188 1 NC_003098.1 hypothetical protein 561188 933329 spr0559 Streptococcus pneumoniae R6 hypothetical protein NP_358153.1 560403 D 171101 CDS NP_358154.1 15902604 933343 561441..561686 1 NC_003098.1 hypothetical protein 561686 933343 spr0560 Streptococcus pneumoniae R6 hypothetical protein NP_358154.1 561441 D 171101 CDS YP_008719800.1 555247346 17374505 complement(561962..562186) 1 NC_003098.1 hypothetical protein 562186 17374505 spr0560a Streptococcus pneumoniae R6 hypothetical protein YP_008719800.1 561962 R 171101 CDS NP_358155.1 15902605 933322 562418..568852 1 NC_003098.1 cell wall-associated serine proteinase PrtA 568852 prtA 933322 prtA Streptococcus pneumoniae R6 cell wall-associated serine proteinase PrtA NP_358155.1 562418 D 171101 CDS NP_358156.1 15902606 933332 569431..569952 1 NC_003098.1 PTS system transporter subunit IIA 569952 PTS-EII 933332 PTS-EII Streptococcus pneumoniae R6 PTS system transporter subunit IIA NP_358156.1 569431 D 171101 CDS NP_358157.1 15902607 933317 569990..570295 1 NC_003098.1 hypothetical protein 570295 933317 spr0563 Streptococcus pneumoniae R6 hypothetical protein NP_358157.1 569990 D 171101 CDS NP_358158.1 15902608 933325 570343..571818 1 NC_003098.1 PTS system transporter subunit IIC 571818 PTS-EII 933325 PTS-EII Streptococcus pneumoniae R6 PTS system transporter subunit IIC NP_358158.1 570343 D 171101 CDS NP_358159.1 15902609 933305 572123..578809 1 NC_003098.1 beta-galactosidase 578809 bgaA 933305 bgaA Streptococcus pneumoniae R6 beta-galactosidase NP_358159.1 572123 D 171101 CDS NP_358161.1 15902611 933300 complement(579666..579911) 1 NC_003098.1 hypothetical protein 579911 933300 spr0567 Streptococcus pneumoniae R6 hypothetical protein NP_358161.1 579666 R 171101 CDS NP_358162.1 15902612 933310 complement(580123..580482) 1 NC_003098.1 hypothetical protein 580482 933310 spr0568 Streptococcus pneumoniae R6 hypothetical protein NP_358162.1 580123 R 171101 CDS NP_358163.1 15902613 933312 580406..581026 1 NC_003098.1 hypothetical protein 581026 933312 spr0569 Streptococcus pneumoniae R6 hypothetical protein NP_358163.1 580406 D 171101 CDS NP_358164.1 15902614 933299 581084..581530 1 NC_003098.1 hypothetical protein 581530 933299 spr0570 Streptococcus pneumoniae R6 hypothetical protein NP_358164.1 581084 D 171101 CDS NP_358165.1 15902615 933303 581508..582071 1 NC_003098.1 hypothetical protein 582071 933303 spr0571 Streptococcus pneumoniae R6 hypothetical protein NP_358165.1 581508 D 171101 CDS NP_358166.1 15902616 933301 582064..582318 1 NC_003098.1 hypothetical protein 582318 933301 spr0572 Streptococcus pneumoniae R6 hypothetical protein NP_358166.1 582064 D 171101 CDS NP_358167.1 15902617 933286 582330..584384 1 NC_003098.1 sodium/hydrogen exchanger family protein 584384 nha2 933286 nha2 Streptococcus pneumoniae R6 sodium/hydrogen exchanger family protein NP_358167.1 582330 D 171101 CDS NP_358168.1 15902618 933297 584548..585423 1 NC_003098.1 ribonuclease BN 585423 933297 spr0574 Streptococcus pneumoniae R6 ribonuclease BN NP_358168.1 584548 D 171101 CDS NP_358169.1 15902619 933280 585634..586344 1 NC_003098.1 cytochrome c-type biogenesis protein 586344 ccdA 933280 ccdA Streptococcus pneumoniae R6 cytochrome c-type biogenesis protein NP_358169.1 585634 D 171101 CDS NP_358170.1 15902620 933294 586337..586930 1 NC_003098.1 hypothetical protein 586930 933294 spr0576 Streptococcus pneumoniae R6 hypothetical protein NP_358170.1 586337 D 171101 CDS NP_358171.1 15902621 933291 586941..588053 1 NC_003098.1 this fusion consists of methionine sulfoxide A reductase at the N-terminus and B at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion; bifunctional methionine sulfoxide reductase A/B protein 588053 msrA 933291 msrA Streptococcus pneumoniae R6 bifunctional methionine sulfoxide reductase A/B protein NP_358171.1 586941 D 171101 CDS NP_358172.1 15902622 933285 588303..589058 1 NC_003098.1 DNA-binding response regulator 589058 rr09 933285 rr09 Streptococcus pneumoniae R6 DNA-binding response regulator NP_358172.1 588303 D 171101 CDS NP_358173.1 15902623 933281 589055..590746 1 NC_003098.1 sensor histidine kinase 590746 hk09 933281 hk09 Streptococcus pneumoniae R6 sensor histidine kinase NP_358173.1 589055 D 171101 CDS NP_358174.1 15902624 933233 590841..591425 1 NC_003098.1 hypothetical protein 591425 933233 spr0580 Streptococcus pneumoniae R6 hypothetical protein NP_358174.1 590841 D 171101 CDS NP_358175.1 15902625 933274 591447..597077 1 NC_003098.1 Similar to IgA1 protease; zinc metalloprotease 597077 zmpB 933274 zmpB Streptococcus pneumoniae R6 zinc metalloprotease NP_358175.1 591447 D 171101 CDS NP_358176.1 15902626 933270 597147..598868 1 NC_003098.1 Para-aminobenzoate synthetase 598868 pabB 933270 pabB Streptococcus pneumoniae R6 Para-aminobenzoate synthetase NP_358176.1 597147 D 171101 CDS NP_358177.1 15902627 933221 599026..600015 1 NC_003098.1 Similar to 1,4-beta-N-acetylmuramidase; pneumococcal surface protein 600015 933221 spr0583 Streptococcus pneumoniae R6 pneumococcal surface protein NP_358177.1 599026 D 171101 CDS NP_358178.1 15902628 933239 600133..601110 1 NC_003098.1 glucokinase 601110 glcK 933239 glcK Streptococcus pneumoniae R6 glucokinase NP_358178.1 600133 D 171101 CDS NP_358179.1 15902629 933235 601207..602046 1 NC_003098.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 602046 thyA 933235 thyA Streptococcus pneumoniae R6 thymidylate synthase NP_358179.1 601207 D 171101 CDS NP_358180.1 15902630 933200 complement(602094..602264) 1 NC_003098.1 hypothetical protein 602264 933200 spr0586 Streptococcus pneumoniae R6 hypothetical protein NP_358180.1 602094 R 171101 CDS NP_358182.1 15902632 933224 602334..603269 1 NC_003098.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 603269 miaA 933224 miaA Streptococcus pneumoniae R6 tRNA delta(2)-isopentenylpyrophosphate transferase NP_358182.1 602334 D 171101 CDS NP_358183.1 15902633 933192 603262..604500 1 NC_003098.1 Probable GTP-binding protein; GTP-binding protein HflX 604500 933192 spr0589 Streptococcus pneumoniae R6 GTP-binding protein HflX NP_358183.1 603262 D 171101 CDS NP_358184.1 15902634 933210 604493..605116 1 NC_003098.1 hypothetical protein 605116 933210 spr0590 Streptococcus pneumoniae R6 hypothetical protein NP_358184.1 604493 D 171101 CDS NP_358185.1 15902635 933204 605131..606060 1 NC_003098.1 member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 606060 933204 spr0591 Streptococcus pneumoniae R6 ribonuclease Z NP_358185.1 605131 D 171101 CDS NP_358186.1 15902636 933170 606081..606836 1 NC_003098.1 Probable oxidoreductase; hypothetical protein 606836 933170 spr0592 Streptococcus pneumoniae R6 hypothetical protein NP_358186.1 606081 D 171101 CDS NP_358187.1 15902637 933196 complement(606890..607936) 1 NC_003098.1 transcriptional regulator 607936 cpsY 933196 cpsY Streptococcus pneumoniae R6 transcriptional regulator NP_358187.1 606890 R 171101 CDS NP_358188.1 15902638 933197 607862..608131 1 NC_003098.1 hypothetical protein 608131 933197 spr0594 Streptococcus pneumoniae R6 hypothetical protein NP_358188.1 607862 D 171101 CDS NP_358189.1 15902639 933145 608131..608511 1 NC_003098.1 hypothetical protein 608511 933145 spr0595 Streptococcus pneumoniae R6 hypothetical protein NP_358189.1 608131 D 171101 CDS NP_358190.1 15902640 933177 608630..608827 1 NC_003098.1 hypothetical protein 608827 933177 spr0596 Streptococcus pneumoniae R6 hypothetical protein NP_358190.1 608630 D 171101 CDS NP_358191.1 15902641 933171 complement(608867..609592) 1 NC_003098.1 ribosomal small subunit pseudouridine synthase A 609592 rsuA 933171 rsuA Streptococcus pneumoniae R6 ribosomal small subunit pseudouridine synthase A NP_358191.1 608867 R 171101 CDS NP_358192.1 15902642 933159 609733..611595 1 NC_003098.1 elongation factor Tu family protein 611595 typA 933159 typA Streptococcus pneumoniae R6 elongation factor Tu family protein NP_358192.1 609733 D 171101 CDS NP_358193.1 15902643 933150 611615..611869 1 NC_003098.1 hypothetical protein 611869 933150 spr0599 Streptococcus pneumoniae R6 hypothetical protein NP_358193.1 611615 D 171101 CDS NP_358194.1 15902644 933142 612185..612532 1 NC_003098.1 bacteriocin; hypothetical protein 612532 933142 spr0600 Streptococcus pneumoniae R6 hypothetical protein NP_358194.1 612185 D 171101 CDS NP_358195.1 15902645 933021 612603..614624 1 NC_003098.1 hypothetical protein 614624 933021 spr0601 Streptococcus pneumoniae R6 hypothetical protein NP_358195.1 612603 D 171101 CDS NP_358196.1 15902646 933012 614626..615267 1 NC_003098.1 sodium ABC transporter ATP-binding protein 615267 ABC-NBD 933012 ABC-NBD Streptococcus pneumoniae R6 sodium ABC transporter ATP-binding protein NP_358196.1 614626 D 171101 CDS NP_358197.1 15902647 932998 615371..616723 1 NC_003098.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 616723 murD 932998 murD Streptococcus pneumoniae R6 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase NP_358197.1 615371 D 171101 CDS NP_358198.1 15902648 933002 616727..617785 1 NC_003098.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 617785 murG 933002 murG Streptococcus pneumoniae R6 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase NP_358198.1 616727 D 171101 CDS NP_358199.1 15902649 932989 617795..618985 1 NC_003098.1 cell division protein DivIB 618985 divIB 932989 divIB Streptococcus pneumoniae R6 cell division protein DivIB NP_358199.1 617795 D 171101 CDS NP_358201.1 15902651 932983 619725..620573 1 NC_003098.1 hypothetical protein 620573 932983 spr0607 Streptococcus pneumoniae R6 hypothetical protein NP_358201.1 619725 D 171101 CDS NP_358205.1 15902655 932963 622965..623678 1 NC_003098.1 membrane spanning protein; hypothetical protein 623678 932963 spr0611 Streptococcus pneumoniae R6 hypothetical protein NP_358205.1 622965 D 171101 CDS NP_358207.1 15902657 932958 624413..625114 1 NC_003098.1 OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 625114 pyrF 932958 pyrF Streptococcus pneumoniae R6 orotidine 5'-phosphate decarboxylase NP_358207.1 624413 D 171101 CDS NP_358208.1 15902658 932949 625148..625780 1 NC_003098.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 625780 pyrE 932949 pyrE Streptococcus pneumoniae R6 orotate phosphoribosyltransferase NP_358208.1 625148 D 171101 CDS NP_358209.1 15902659 934889 625960..626364 1 NC_003098.1 hypothetical protein 626364 934889 spr0615 Streptococcus pneumoniae R6 hypothetical protein NP_358209.1 625960 D 171101 CDS NP_358210.1 15902660 932946 626460..627224 1 NC_003098.1 hypothetical protein 627224 932946 spr0616 Streptococcus pneumoniae R6 hypothetical protein NP_358210.1 626460 D 171101 CDS NP_358211.1 15902661 932944 627173..627976 1 NC_003098.1 hypothetical protein 627976 932944 spr0617 Streptococcus pneumoniae R6 hypothetical protein NP_358211.1 627173 D 171101 CDS NP_358212.1 15902662 932924 627980..628684 1 NC_003098.1 hypothetical protein 628684 932924 spr0618 Streptococcus pneumoniae R6 hypothetical protein NP_358212.1 627980 D 171101 CDS NP_358213.1 15902663 934873 628681..629328 1 NC_003098.1 ABC transporter ATP-binding protein 629328 ABC-NBD 934873 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358213.1 628681 D 171101 CDS NP_358216.1 15902666 934886 complement(630285..631043) 1 NC_003098.1 amino acid ABC transporter ATP-binding protein 631043 glnQ 934886 glnQ Streptococcus pneumoniae R6 amino acid ABC transporter ATP-binding protein NP_358216.1 630285 R 171101 CDS NP_358217.1 15902667 932849 complement(631044..631721) 1 NC_003098.1 amino acid ABC transporter permease 631721 glnP 932849 glnP Streptococcus pneumoniae R6 amino acid ABC transporter permease NP_358217.1 631044 R 171101 CDS NP_358218.1 15902668 932908 complement(631681..632361) 1 NC_003098.1 amino acid ABC transporter permease 632361 glnP 932908 glnP Streptococcus pneumoniae R6 amino acid ABC transporter permease NP_358218.1 631681 R 171101 CDS NP_358220.1 15902670 932817 632850..634340 1 NC_003098.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 634340 lysS 932817 lysS Streptococcus pneumoniae R6 lysyl-tRNA synthetase NP_358220.1 632850 D 171101 CDS NP_358221.1 15902671 932862 634965..636101 1 NC_003098.1 lactate oxidase 636101 lctO 932862 lctO Streptococcus pneumoniae R6 lactate oxidase NP_358221.1 634965 D 171101 CDS NP_358222.1 15902672 932837 636656..637324 1 NC_003098.1 Probable transcriptional regulator; hypothetical protein 637324 932837 spr0628 Streptococcus pneumoniae R6 hypothetical protein NP_358222.1 636656 D 171101 CDS NP_358223.1 15902673 934546 637592..638395 1 NC_003098.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 638395 thiM 934546 thiM Streptococcus pneumoniae R6 hydroxyethylthiazole kinase NP_358223.1 637592 D 171101 CDS NP_358224.1 15902674 932808 638397..639026 1 NC_003098.1 thiamine-phosphate pyrophosphorylase 639026 thiE 932808 thiE Streptococcus pneumoniae R6 thiamine-phosphate pyrophosphorylase NP_358224.1 638397 D 171101 CDS NP_358225.1 15902675 934636 639551..640144 1 NC_003098.1 hypothetical protein 640144 934636 spr0631 Streptococcus pneumoniae R6 hypothetical protein NP_358225.1 639551 D 171101 CDS NP_358226.1 15902676 934174 640145..641530 1 NC_003098.1 ABC transporter ATP-binding protein 641530 ABC-NBD 934174 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358226.1 640145 D 171101 CDS NP_358227.1 15902677 934339 641532..642182 1 NC_003098.1 hypothetical protein 642182 934339 spr0633 Streptococcus pneumoniae R6 hypothetical protein NP_358227.1 641532 D 171101 CDS NP_358228.1 15902678 934245 642193..642885 1 NC_003098.1 extracellular enzyme gene transcriptional regulator 642885 tenA 934245 tenA Streptococcus pneumoniae R6 extracellular enzyme gene transcriptional regulator NP_358228.1 642193 D 171101 CDS NP_358229.1 15902679 934493 642890..643414 1 NC_003098.1 hypothetical protein 643414 934493 spr0635 Streptococcus pneumoniae R6 hypothetical protein NP_358229.1 642890 D 171101 CDS NP_358230.1 15902680 934435 643414..644217 1 NC_003098.1 hydroxyethylthiazole kinase 644217 thiM 934435 thiM Streptococcus pneumoniae R6 hydroxyethylthiazole kinase NP_358230.1 643414 D 171101 CDS NP_358231.1 15902681 934175 644210..644842 1 NC_003098.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 644842 thiE 934175 thiE Streptococcus pneumoniae R6 thiamine-phosphate pyrophosphorylase NP_358231.1 644210 D 171101 CDS NP_358232.1 15902682 934176 complement(645051..645842) 1 NC_003098.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 645842 thiD 934176 thiD Streptococcus pneumoniae R6 phosphomethylpyrimidine kinase NP_358232.1 645051 R 171101 CDS NP_358233.1 15902683 934180 646178..646603 1 NC_003098.1 COPAB ATPase metal-fist type repressor 646603 copY 934180 copY Streptococcus pneumoniae R6 COPAB ATPase metal-fist type repressor NP_358233.1 646178 D 171101 CDS NP_358234.1 15902684 934190 646614..646985 1 NC_003098.1 hypothetical protein 646985 934190 spr0640 Streptococcus pneumoniae R6 hypothetical protein NP_358234.1 646614 D 171101 CDS NP_358235.1 15902685 934178 646986..649238 1 NC_003098.1 copper transporter P-type ATPase 649238 ctpA 934178 ctpA Streptococcus pneumoniae R6 copper transporter P-type ATPase NP_358235.1 646986 D 171101 CDS NP_358236.1 15902686 934181 649445..651220 1 NC_003098.1 pyruvate oxidase 651220 spxB 934181 spxB Streptococcus pneumoniae R6 pyruvate oxidase NP_358236.1 649445 D 171101 CDS NP_358237.1 15902687 934177 651331..651678 1 NC_003098.1 hypothetical protein 651678 934177 spr0643 Streptococcus pneumoniae R6 hypothetical protein NP_358237.1 651331 D 171101 CDS NP_358238.1 15902688 934179 complement(651795..652448) 1 NC_003098.1 transposase 652448 transposase_C 934179 transposase_C Streptococcus pneumoniae R6 transposase NP_358238.1 651795 R 171101 CDS NP_358239.1 15902689 934183 complement(652336..652683) 1 NC_003098.1 hypothetical protein 652683 934183 spr0645 Streptococcus pneumoniae R6 hypothetical protein NP_358239.1 652336 R 171101 CDS NP_358241.1 15902691 934184 653533..654477 1 NC_003098.1 mannose-6-phosphate isomerase 654477 pmi 934184 pmi Streptococcus pneumoniae R6 mannose-6-phosphate isomerase NP_358241.1 653533 D 171101 CDS NP_358242.1 15902692 934182 complement(654580..655971) 1 NC_003098.1 sodium-dependent transporter 655971 NS_transporter 934182 NS_transporter Streptococcus pneumoniae R6 sodium-dependent transporter NP_358242.1 654580 R 171101 CDS NP_358243.1 15902693 934189 656131..656793 1 NC_003098.1 regulator of the multidrug efflux pump pmrA 656793 mta 934189 mta Streptococcus pneumoniae R6 regulator of the multidrug efflux pump pmrA NP_358243.1 656131 D 171101 CDS NP_358244.1 15902694 934185 complement(656822..657277) 1 NC_003098.1 Similar to mutator protein MutT; hypothetical protein 657277 934185 spr0650 Streptococcus pneumoniae R6 hypothetical protein NP_358244.1 656822 R 171101 CDS NP_358245.1 15902695 934187 complement(657297..658490) 1 NC_003098.1 hypothetical protein 658490 934187 spr0651 Streptococcus pneumoniae R6 hypothetical protein NP_358245.1 657297 R 171101 CDS NP_358246.1 15902696 934192 complement(658531..659376) 1 NC_003098.1 hypothetical protein 659376 934192 spr0652 Streptococcus pneumoniae R6 hypothetical protein NP_358246.1 658531 R 171101 CDS NP_358247.1 15902697 934188 659501..660058 1 NC_003098.1 Probable transcriptional regulator; hypothetical protein 660058 934188 spr0653 Streptococcus pneumoniae R6 hypothetical protein NP_358247.1 659501 D 171101 CDS NP_358248.1 15902698 934191 660077..660544 1 NC_003098.1 late competence operon required for DNA binding and uptake; cytidine and deoxycytidylate deaminase 660544 comEB 934191 comEB Streptococcus pneumoniae R6 cytidine and deoxycytidylate deaminase NP_358248.1 660077 D 171101 CDS NP_358249.1 15902699 934196 660612..661262 1 NC_003098.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 661262 upp 934196 upp Streptococcus pneumoniae R6 uracil phosphoribosyltransferase NP_358249.1 660612 D 171101 CDS NP_358250.1 15902700 934194 661436..662026 1 NC_003098.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 662026 clpP 934194 clpP Streptococcus pneumoniae R6 ATP-dependent Clp protease proteolytic subunit NP_358250.1 661436 D 171101 CDS NP_358251.1 15902701 934193 662105..662353 1 NC_003098.1 hypothetical protein 662353 934193 spr0657 Streptococcus pneumoniae R6 hypothetical protein NP_358251.1 662105 D 171101 CDS NP_358252.1 15902702 934197 complement(662219..662449) 1 NC_003098.1 hypothetical protein 662449 934197 spr0658 Streptococcus pneumoniae R6 hypothetical protein NP_358252.1 662219 R 171101 CDS NP_358253.1 15902703 934202 662455..663615 1 NC_003098.1 branched chain amino acid ABC transporter substrate+B481-binding protein 663615 livJ 934202 livJ Streptococcus pneumoniae R6 branched chain amino acid ABC transporter substrate+B481-binding protein NP_358253.1 662455 D 171101 CDS NP_358254.1 15902704 934200 663874..664752 1 NC_003098.1 branched chain amino acid ABC transporter permease 664752 livH 934200 livH Streptococcus pneumoniae R6 branched chain amino acid ABC transporter permease NP_358254.1 663874 D 171101 CDS NP_358255.1 15902705 934195 664756..665712 1 NC_003098.1 branched chain amino acid ABC transporter permease 665712 livM 934195 livM Streptococcus pneumoniae R6 branched chain amino acid ABC transporter permease NP_358255.1 664756 D 171101 CDS NP_358256.1 15902706 934198 665712..666476 1 NC_003098.1 branched chain amino acid ABC transporter ATP-binding protein 666476 livG 934198 livG Streptococcus pneumoniae R6 branched chain amino acid ABC transporter ATP-binding protein NP_358256.1 665712 D 171101 CDS NP_358257.1 15902707 934205 666476..667186 1 NC_003098.1 branched chain amino acid ABC transporter ATP-binding protein 667186 livF 934205 livF Streptococcus pneumoniae R6 branched chain amino acid ABC transporter ATP-binding protein NP_358257.1 666476 D 171101 CDS NP_358258.1 15902708 934199 667600..668256 1 NC_003098.1 acetoin utilization protein AcuB 668256 934199 spr0664 Streptococcus pneumoniae R6 acetoin utilization protein AcuB NP_358258.1 667600 D 171101 CDS NP_358259.1 15902709 934204 668470..669459 1 NC_003098.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 669459 prfB 934204 prfB Streptococcus pneumoniae R6 peptide chain release factor 2 NP_358259.1 668470 D 171101 CDS NP_358260.1 15902710 934207 669477..670169 1 NC_003098.1 ABC transporter ATP-binding protein 670169 ftsE 934207 ftsE Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358260.1 669477 D 171101 CDS NP_358261.1 15902711 934201 670099..671088 1 NC_003098.1 cell division ABC transporter permease FtsX 671088 ftsX 934201 ftsX Streptococcus pneumoniae R6 cell division ABC transporter permease FtsX NP_358261.1 670099 D 171101 CDS NP_358262.1 15902712 934203 671374..673554 1 NC_003098.1 PTS system transporter subunit IIABC 673554 ptsG 934203 ptsG Streptococcus pneumoniae R6 PTS system transporter subunit IIABC NP_358262.1 671374 D 171101 CDS NP_358263.1 15902713 934209 673606..674421 1 NC_003098.1 hypothetical protein 674421 934209 spr0669 Streptococcus pneumoniae R6 hypothetical protein NP_358263.1 673606 D 171101 CDS NP_358264.1 15902714 934208 674561..675904 1 NC_003098.1 ATP-dependent RNA helicase 675904 rheB 934208 rheB Streptococcus pneumoniae R6 ATP-dependent RNA helicase NP_358264.1 674561 D 171101 CDS NP_358265.1 15902715 934206 676119..677309 1 NC_003098.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 677309 metK 934206 metK Streptococcus pneumoniae R6 S-adenosylmethionine synthetase NP_358265.1 676119 D 171101 CDS NP_358266.1 15902716 934210 677862..678797 1 NC_003098.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 678797 pyrDA 934210 pyrDA Streptococcus pneumoniae R6 dihydroorotate dehydrogenase 1A NP_358266.1 677862 D 171101 CDS NP_358267.1 15902717 934219 678831..679868 1 NC_003098.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 679868 holA 934219 holA Streptococcus pneumoniae R6 DNA polymerase III subunit delta NP_358267.1 678831 D 171101 CDS NP_358268.1 15902718 934215 680041..680646 1 NC_003098.1 superoxide dismutase 680646 sodA 934215 sodA Streptococcus pneumoniae R6 superoxide dismutase NP_358268.1 680041 D 171101 CDS NP_358269.1 15902719 934214 680803..681333 1 NC_003098.1 hypothetical protein 681333 934214 spr0675 Streptococcus pneumoniae R6 hypothetical protein NP_358269.1 680803 D 171101 CDS NP_358270.1 15902720 934211 681354..682439 1 NC_003098.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 682439 934211 spr0676 Streptococcus pneumoniae R6 ribosomal RNA large subunit methyltransferase N NP_358270.1 681354 D 171101 CDS NP_358271.1 15902721 934218 682441..682908 1 NC_003098.1 hypothetical protein 682908 934218 spr0677 Streptococcus pneumoniae R6 hypothetical protein NP_358271.1 682441 D 171101 CDS NP_358272.1 15902722 934213 682910..684451 1 NC_003098.1 ABC transporter ATP-binding protein 684451 ABC-NBD 934213 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358272.1 682910 D 171101 CDS NP_358273.1 15902723 934212 complement(684508..685311) 1 NC_003098.1 peptidyl-prolyl cis-trans isomerase 685311 ppiA 934212 ppiA Streptococcus pneumoniae R6 peptidyl-prolyl cis-trans isomerase NP_358273.1 684508 R 171101 CDS NP_358274.1 15902724 934228 complement(685395..685616) 1 NC_003098.1 hypothetical protein 685616 934228 spr0680 Streptococcus pneumoniae R6 hypothetical protein NP_358274.1 685395 R 171101 CDS NP_358275.1 15902725 934216 complement(685504..685734) 1 NC_003098.1 hypothetical protein 685734 934216 spr0681 Streptococcus pneumoniae R6 hypothetical protein NP_358275.1 685504 R 171101 CDS NP_358276.1 15902726 934220 686482..686754 1 NC_003098.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 686754 rpsP 934220 rpsP Streptococcus pneumoniae R6 30S ribosomal protein S16 NP_358276.1 686482 D 171101 CDS NP_358277.1 15902727 934222 686774..687013 1 NC_003098.1 hypothetical protein 687013 934222 spr0683 Streptococcus pneumoniae R6 hypothetical protein NP_358277.1 686774 D 171101 CDS NP_358280.1 15902730 934224 688409..688927 1 NC_003098.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 688927 rimM 934224 rimM Streptococcus pneumoniae R6 16S rRNA-processing protein RimM NP_358280.1 688409 D 171101 CDS NP_358281.1 15902731 934221 688917..689636 1 NC_003098.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 689636 trmD 934221 trmD Streptococcus pneumoniae R6 tRNA (guanine-N(1)-)-methyltransferase NP_358281.1 688917 D 171101 CDS NP_358282.1 15902732 934227 689648..689986 1 NC_003098.1 hypothetical protein 689986 934227 spr0688 Streptococcus pneumoniae R6 hypothetical protein NP_358282.1 689648 D 171101 CDS NP_358283.1 15902733 934226 complement(690017..690337) 1 NC_003098.1 hypothetical protein 690337 934226 spr0689 Streptococcus pneumoniae R6 hypothetical protein NP_358283.1 690017 R 171101 CDS NP_358284.1 15902734 934225 690411..690650 1 NC_003098.1 hypothetical protein 690650 934225 spr0690 Streptococcus pneumoniae R6 hypothetical protein NP_358284.1 690411 D 171101 CDS NP_358285.1 15902735 934230 complement(690854..691390) 1 NC_003098.1 biotin synthase 691390 bioY 934230 bioY Streptococcus pneumoniae R6 biotin synthase NP_358285.1 690854 R 171101 CDS NP_358286.1 15902736 934234 complement(691587..692933) 1 NC_003098.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 692933 gor 934234 gor Streptococcus pneumoniae R6 glutathione reductase NP_358286.1 691587 R 171101 CDS NP_358287.1 15902737 934233 693198..694397 1 NC_003098.1 hypothetical protein 694397 934233 spr0693 Streptococcus pneumoniae R6 hypothetical protein NP_358287.1 693198 D 171101 CDS NP_358288.1 15902738 934229 694381..695082 1 NC_003098.1 ABC transporter ATP-binding protein 695082 ABC-NBD 934229 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358288.1 694381 D 171101 CDS NP_358289.1 15902739 934232 695084..696343 1 NC_003098.1 hypothetical protein 696343 934232 spr0695 Streptococcus pneumoniae R6 hypothetical protein NP_358289.1 695084 D 171101 CDS NP_358290.2 161410751 934240 696467..698464 1 NC_003098.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 698464 metG 934240 metG Streptococcus pneumoniae R6 methionyl-tRNA synthetase NP_358290.2 696467 D 171101 CDS YP_008719801.1 555247347 17374506 698514..698705 1 NC_003098.1 hypothetical protein 698705 17374506 spr0696a Streptococcus pneumoniae R6 hypothetical protein YP_008719801.1 698514 D 171101 CDS NP_358291.1 15902741 934231 698792..699115 1 NC_003098.1 hypothetical protein 699115 934231 spr0697 Streptococcus pneumoniae R6 hypothetical protein NP_358291.1 698792 D 171101 CDS NP_358292.1 15902742 934238 699119..699994 1 NC_003098.1 hypothetical protein 699994 934238 spr0698 Streptococcus pneumoniae R6 hypothetical protein NP_358292.1 699119 D 171101 CDS NP_358293.1 15902743 934236 700006..700935 1 NC_003098.1 hypothetical protein 700935 934236 spr0699 Streptococcus pneumoniae R6 hypothetical protein NP_358293.1 700006 D 171101 CDS NP_358294.1 15902744 934235 701014..701271 1 NC_003098.1 hypothetical protein 701271 934235 spr0700 Streptococcus pneumoniae R6 hypothetical protein NP_358294.1 701014 D 171101 CDS NP_358295.1 15902745 934242 701264..701962 1 NC_003098.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 701962 fabG 934242 fabG Streptococcus pneumoniae R6 3-ketoacyl-ACP reductase NP_358295.1 701264 D 171101 CDS NP_358296.1 15902746 934237 701973..702452 1 NC_003098.1 MutT/nudix family protein 702452 934237 spr0702 Streptococcus pneumoniae R6 MutT/nudix family protein NP_358296.1 701973 D 171101 CDS NP_358297.1 15902747 934250 702460..703188 1 NC_003098.1 hypothetical protein 703188 934250 spr0703 Streptococcus pneumoniae R6 hypothetical protein NP_358297.1 702460 D 171101 CDS NP_358298.1 15902748 934243 703224..704099 1 NC_003098.1 hypothetical protein 704099 934243 spr0704 Streptococcus pneumoniae R6 hypothetical protein NP_358298.1 703224 D 171101 CDS NP_358299.1 15902749 934239 704074..704514 1 NC_003098.1 hypothetical protein 704514 934239 spr0705 Streptococcus pneumoniae R6 hypothetical protein NP_358299.1 704074 D 171101 CDS NP_358300.1 15902750 934241 704637..707183 1 NC_003098.1 aminopeptidase 707183 pepN 934241 pepN Streptococcus pneumoniae R6 aminopeptidase NP_358300.1 704637 D 171101 CDS NP_358301.1 15902751 934251 707226..707966 1 NC_003098.1 DNA-binding response regulator CiaR 707966 ciaR 934251 ciaR Streptococcus pneumoniae R6 DNA-binding response regulator CiaR NP_358301.1 707226 D 171101 CDS NP_358302.1 15902752 934244 707956..709290 1 NC_003098.1 sensor histidine kinase CiaH 709290 ciaH 934244 ciaH Streptococcus pneumoniae R6 sensor histidine kinase CiaH NP_358302.1 707956 D 171101 CDS NP_358303.1 15902753 934248 complement(709324..709611) 1 NC_003098.1 hypothetical protein 709611 934248 spr0709 Streptococcus pneumoniae R6 hypothetical protein NP_358303.1 709324 R 171101 CDS NP_358304.1 15902754 934270 709610..710680 1 NC_003098.1 Similar to protease; hypothetical protein 710680 934270 spr0710 Streptococcus pneumoniae R6 hypothetical protein NP_358304.1 709610 D 171101 CDS NP_358305.1 15902755 934246 710880..713330 1 NC_003098.1 unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 713330 dinG 934246 dinG Streptococcus pneumoniae R6 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon NP_358305.1 710880 D 171101 CDS NP_358306.1 15902756 934247 713340..714590 1 NC_003098.1 rod shape-determining protein RodA 714590 rodA 934247 rodA Streptococcus pneumoniae R6 rod shape-determining protein RodA NP_358306.1 713340 D 171101 CDS NP_358307.1 15902757 934252 714601..715155 1 NC_003098.1 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein 715155 thiJ 934252 thiJ Streptococcus pneumoniae R6 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein NP_358307.1 714601 D 171101 CDS NP_358308.1 15902758 934249 715231..715803 1 NC_003098.1 phosphoglycolate phosphatase 715803 gph 934249 gph Streptococcus pneumoniae R6 phosphoglycolate phosphatase NP_358308.1 715231 D 171101 CDS NP_358309.1 15902759 934253 715818..717764 1 NC_003098.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 717764 gyrB 934253 gyrB Streptococcus pneumoniae R6 DNA gyrase subunit B NP_358309.1 715818 D 171101 CDS NP_358310.1 15902760 934258 717819..719573 1 NC_003098.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 719573 ezrA 934258 ezrA Streptococcus pneumoniae R6 septation ring formation regulator EzrA NP_358310.1 717819 D 171101 CDS NP_358311.1 15902761 934257 720316..720720 1 NC_003098.1 transposase 720720 transposase_C 934257 transposase_C Streptococcus pneumoniae R6 transposase NP_358311.1 720316 D 171101 CDS NP_358312.1 15902762 934256 720608..721261 1 NC_003098.1 transposase 721261 transposase_D 934256 transposase_D Streptococcus pneumoniae R6 transposase NP_358312.1 720608 D 171101 CDS NP_358314.1 15902764 934259 complement(721895..722194) 1 NC_003098.1 hypothetical protein 722194 934259 spr0720 Streptococcus pneumoniae R6 hypothetical protein NP_358314.1 721895 R 171101 CDS NP_358315.1 15902765 934254 complement(722359..722781) 1 NC_003098.1 MutT/nudix family protein 722781 934254 spr0721 Streptococcus pneumoniae R6 MutT/nudix family protein NP_358315.1 722359 R 171101 CDS NP_358316.1 15902766 934263 722874..723221 1 NC_003098.1 transposase 723221 transposase_A 934263 transposase_A Streptococcus pneumoniae R6 transposase NP_358316.1 722874 D 171101 CDS NP_358319.1 15902769 934262 complement(723946..726204) 1 NC_003098.1 ATP dependent protease 726204 clpE 934262 clpE Streptococcus pneumoniae R6 ATP dependent protease NP_358319.1 723946 R 171101 CDS NP_358320.1 15902770 934264 complement(726433..726663) 1 NC_003098.1 hypothetical protein 726663 934264 spr0726 Streptococcus pneumoniae R6 hypothetical protein NP_358320.1 726433 R 171101 CDS NP_358321.1 15902771 934267 726847..727536 1 NC_003098.1 amino acid ABC transporter permease 727536 glnP 934267 glnP Streptococcus pneumoniae R6 amino acid ABC transporter permease NP_358321.1 726847 D 171101 CDS NP_358322.1 15902772 934265 727536..728270 1 NC_003098.1 amino acid ABC transporter ATP-binding protein 728270 glnQ 934265 glnQ Streptococcus pneumoniae R6 amino acid ABC transporter ATP-binding protein NP_358322.1 727536 D 171101 CDS NP_358323.1 15902773 934266 728361..729281 1 NC_003098.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 729281 folD 934266 folD Streptococcus pneumoniae R6 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase NP_358323.1 728361 D 171101 CDS NP_358324.1 15902774 934273 729423..730295 1 NC_003098.1 hypothetical protein 730295 934273 spr0730 Streptococcus pneumoniae R6 hypothetical protein NP_358324.1 729423 D 171101 CDS NP_358325.1 15902775 934268 730520..731260 1 NC_003098.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 731260 rpiA 934268 rpiA Streptococcus pneumoniae R6 ribose-5-phosphate isomerase A NP_358325.1 730520 D 171101 CDS NP_358326.1 15902776 934269 731211..732485 1 NC_003098.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 732485 deoB 934269 deoB Streptococcus pneumoniae R6 phosphopentomutase NP_358326.1 731211 D 171101 CDS NP_358328.1 15902778 934285 733045..733854 1 NC_003098.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 733854 pnp 934285 pnp Streptococcus pneumoniae R6 purine nucleoside phosphorylase NP_358328.1 733045 D 171101 CDS NP_358331.1 15902781 934271 735335..735847 1 NC_003098.1 Related to a cytolysin; hemolysin-like protein 735847 934271 spr0737 Streptococcus pneumoniae R6 hemolysin-like protein NP_358331.1 735335 D 171101 CDS NP_358332.1 15902782 934280 736505..737215 1 NC_003098.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 737215 deoD 934280 deoD Streptococcus pneumoniae R6 purine nucleoside phosphorylase NP_358332.1 736505 D 171101 CDS NP_358333.1 15902783 934274 complement(737238..737762) 1 NC_003098.1 topology modulation protein 737762 flaR 934274 flaR Streptococcus pneumoniae R6 topology modulation protein NP_358333.1 737238 R 171101 CDS NP_358334.2 161410750 934276 complement(737815..738051) 1 NC_003098.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 738051 rpsT 934276 rpsT Streptococcus pneumoniae R6 30S ribosomal protein S20 NP_358334.2 737815 R 171101 CDS NP_358335.1 15902785 934284 complement(738119..739069) 1 NC_003098.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 739069 coaA 934284 coaA Streptococcus pneumoniae R6 pantothenate kinase NP_358335.1 738119 R 171101 CDS NP_358336.1 15902786 934278 739237..739677 1 NC_003098.1 hypothetical protein 739677 934278 spr0742 Streptococcus pneumoniae R6 hypothetical protein NP_358336.1 739237 D 171101 CDS NP_358337.1 15902787 934279 739884..740474 1 NC_003098.1 hypothetical protein 740474 934279 spr0743 Streptococcus pneumoniae R6 hypothetical protein NP_358337.1 739884 D 171101 CDS NP_358338.1 15902788 934286 740471..741748 1 NC_003098.1 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 741748 pdp 934286 pdp Streptococcus pneumoniae R6 pyrimidine-nucleoside phosphorylase NP_358338.1 740471 D 171101 CDS NP_358339.1 15902789 934282 741766..742428 1 NC_003098.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 742428 deoC 934282 deoC Streptococcus pneumoniae R6 deoxyribose-phosphate aldolase NP_358339.1 741766 D 171101 CDS NP_358340.1 15902790 934281 742415..742804 1 NC_003098.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 742804 cdd 934281 cdd Streptococcus pneumoniae R6 cytidine deaminase NP_358340.1 742415 D 171101 CDS NP_358341.1 15902791 934288 742822..743946 1 NC_003098.1 Similar to basic membrane protein A from Lactococcus lactis subsp. lactis; hypothetical protein 743946 934288 spr0747 Streptococcus pneumoniae R6 hypothetical protein NP_358341.1 742822 D 171101 CDS NP_358342.1 15902792 934283 744090..745625 1 NC_003098.1 sugar ABC transporter ATP-binding protein 745625 ABC-NBD 934283 ABC-NBD Streptococcus pneumoniae R6 sugar ABC transporter ATP-binding protein NP_358342.1 744090 D 171101 CDS NP_358343.1 15902793 934289 745591..746676 1 NC_003098.1 sugar ABC transporter permease 746676 ABC-MSP 934289 ABC-MSP Streptococcus pneumoniae R6 sugar ABC transporter permease NP_358343.1 745591 D 171101 CDS NP_358344.1 15902794 934291 746679..747635 1 NC_003098.1 sugar ABC transporter permease 747635 ABC-MSP 934291 ABC-MSP Streptococcus pneumoniae R6 sugar ABC transporter permease NP_358344.1 746679 D 171101 CDS NP_358349.1 15902799 934290 complement(749110..749751) 1 NC_003098.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 749751 934290 spr0755 Streptococcus pneumoniae R6 glycerol-3-phosphate acyltransferase PlsY NP_358349.1 749110 R 171101 CDS NP_358350.1 15902800 934298 749887..751830 1 NC_003098.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 751830 parE 934298 parE Streptococcus pneumoniae R6 DNA topoisomerase IV subunit B NP_358350.1 749887 D 171101 CDS NP_358351.1 15902801 934295 752241..754721 1 NC_003098.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 754721 parC 934295 parC Streptococcus pneumoniae R6 DNA topoisomerase IV subunit A NP_358351.1 752241 D 171101 CDS NP_358352.1 15902802 934293 754851..755873 1 NC_003098.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 755873 ilvE 934293 ilvE Streptococcus pneumoniae R6 branched-chain amino acid aminotransferase NP_358352.1 754851 D 171101 CDS NP_358354.1 15902804 934297 756677..757387 1 NC_003098.1 integral membrane protein; hypothetical protein 757387 934297 spr0760 Streptococcus pneumoniae R6 hypothetical protein NP_358354.1 756677 D 171101 CDS NP_358355.1 15902805 934296 757384..758307 1 NC_003098.1 membrane protein; hypothetical protein 758307 934296 spr0761 Streptococcus pneumoniae R6 hypothetical protein NP_358355.1 757384 D 171101 CDS NP_358356.1 15902806 934303 758322..758966 1 NC_003098.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 758966 pcp 934303 pcp Streptococcus pneumoniae R6 pyrrolidone-carboxylate peptidase NP_358356.1 758322 D 171101 CDS NP_358357.1 15902807 934299 759134..759364 1 NC_003098.1 hypothetical protein 759364 934299 spr0763 Streptococcus pneumoniae R6 hypothetical protein NP_358357.1 759134 D 171101 CDS NP_358358.1 15902808 934311 759737..760939 1 NC_003098.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 760939 rpsA 934311 rpsA Streptococcus pneumoniae R6 30S ribosomal protein S1 NP_358358.1 759737 D 171101 CDS NP_358361.1 15902811 934313 complement(761883..762401) 1 NC_003098.1 transposase 762401 IS1167 934313 IS1167 Streptococcus pneumoniae R6 transposase NP_358361.1 761883 R 171101 CDS NP_358362.1 15902812 934307 762595..763092 1 NC_003098.1 hypothetical protein 763092 934307 spr0768 Streptococcus pneumoniae R6 hypothetical protein NP_358362.1 762595 D 171101 CDS NP_358363.1 15902813 934308 763092..764747 1 NC_003098.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 764747 dnaX 934308 dnaX Streptococcus pneumoniae R6 DNA polymerase III subunits gamma and tau NP_358363.1 763092 D 171101 CDS NP_358364.1 15902814 934314 764775..764969 1 NC_003098.1 hypothetical protein 764969 934314 spr0770 Streptococcus pneumoniae R6 hypothetical protein NP_358364.1 764775 D 171101 CDS NP_358365.1 15902815 934309 765098..765889 1 NC_003098.1 ABC transporter ATP-binding protein 765889 ABC-NBD 934309 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358365.1 765098 D 171101 CDS NP_358366.1 15902816 934310 765917..767179 1 NC_003098.1 hypothetical protein 767179 934310 spr0772 Streptococcus pneumoniae R6 hypothetical protein NP_358366.1 765917 D 171101 CDS NP_358367.1 15902817 934318 767190..768416 1 NC_003098.1 Probable class-V aminotransferase; hypothetical protein 768416 934318 spr0773 Streptococcus pneumoniae R6 hypothetical protein NP_358367.1 767190 D 171101 CDS NP_358368.1 15902818 934312 768403..768843 1 NC_003098.1 NifU protein 768843 nifU 934312 nifU Streptococcus pneumoniae R6 NifU protein NP_358368.1 768403 D 171101 CDS NP_358369.1 15902819 934317 768897..770309 1 NC_003098.1 hypothetical protein 770309 934317 spr0775 Streptococcus pneumoniae R6 hypothetical protein NP_358369.1 768897 D 171101 CDS NP_358370.1 15902820 934315 complement(770508..771749) 1 NC_003098.1 D-alanyl-D-alanine carboxypeptidase 771749 dacA 934315 dacA Streptococcus pneumoniae R6 D-alanyl-D-alanine carboxypeptidase NP_358370.1 770508 R 171101 CDS NP_358371.1 15902821 934316 771852..772961 1 NC_003098.1 permease; hypothetical protein 772961 934316 spr0777 Streptococcus pneumoniae R6 hypothetical protein NP_358371.1 771852 D 171101 CDS NP_358372.1 15902822 934319 774386..775126 1 NC_003098.1 lactose PTS system repressor 775126 fruR 934319 fruR Streptococcus pneumoniae R6 lactose PTS system repressor NP_358372.1 774386 D 171101 CDS NP_358373.1 15902823 934324 775123..776034 1 NC_003098.1 1-phosphofructokinase 776034 fruB 934324 fruB Streptococcus pneumoniae R6 1-phosphofructokinase NP_358373.1 775123 D 171101 CDS NP_358374.1 15902824 934325 776031..777983 1 NC_003098.1 PTS system fructose specific transporter subunit IIABC 777983 fruA 934325 fruA Streptococcus pneumoniae R6 PTS system fructose specific transporter subunit IIABC NP_358374.1 776031 D 171101 CDS NP_358375.1 15902825 934321 778069..780372 1 NC_003098.1 SpoE family protein 780372 ftsK 934321 ftsK Streptococcus pneumoniae R6 SpoE family protein NP_358375.1 778069 D 171101 CDS NP_358376.1 15902826 934327 complement(780417..780950) 1 NC_003098.1 hypothetical protein 780950 934327 spr0782 Streptococcus pneumoniae R6 hypothetical protein NP_358376.1 780417 R 171101 CDS NP_358377.1 15902827 934333 780983..782125 1 NC_003098.1 pyridoxal-phosphate dependent aminotransferase 782125 934333 spr0783 Streptococcus pneumoniae R6 pyridoxal-phosphate dependent aminotransferase NP_358377.1 780983 D 171101 CDS NP_358378.1 15902828 934323 782134..783348 1 NC_003098.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 783348 thiI 934323 thiI Streptococcus pneumoniae R6 thiamine biosynthesis protein ThiI NP_358378.1 782134 D 171101 CDS NP_358379.1 15902829 934329 783459..784307 1 NC_003098.1 hypothetical protein 784307 934329 spr0785 Streptococcus pneumoniae R6 hypothetical protein NP_358379.1 783459 D 171101 CDS NP_358383.1 15902833 934330 785081..786247 1 NC_003098.1 hypothetical protein 786247 934330 spr0789 Streptococcus pneumoniae R6 hypothetical protein NP_358383.1 785081 D 171101 CDS NP_358384.1 15902834 934337 786755..788248 1 NC_003098.1 type I restriction-modification system M subunit 788248 hsdM 934337 hsdM Streptococcus pneumoniae R6 type I restriction-modification system M subunit NP_358384.1 786755 D 171101 CDS NP_358385.1 15902835 934328 788261..788872 1 NC_003098.1 type I restriction-modification system S subunit 788872 hsdS 934328 hsdS Streptococcus pneumoniae R6 type I restriction-modification system S subunit NP_358385.1 788261 D 171101 CDS NP_358386.1 15902836 934335 788951..792301 1 NC_003098.1 type I restriction-modification system R subunit 792301 hsdR 934335 hsdR Streptococcus pneumoniae R6 type I restriction-modification system R subunit NP_358386.1 788951 D 171101 CDS YP_008719802.1 555247348 17374507 792572..792772 1 NC_003098.1 hypothetical protein 792772 17374507 spr0792a Streptococcus pneumoniae R6 hypothetical protein YP_008719802.1 792572 D 171101 CDS NP_358387.1 15902837 934338 complement(792887..793357) 1 NC_003098.1 arginine repressor ArgR 793357 argR 934338 argR Streptococcus pneumoniae R6 arginine repressor ArgR NP_358387.1 792887 R 171101 CDS NP_358388.1 15902838 934358 complement(793374..795761) 1 NC_003098.1 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase 795761 pepXP 934358 pepXP Streptococcus pneumoniae R6 x-prolyl-dipeptidyl aminopeptidase NP_358388.1 793374 R 171101 CDS NP_358389.1 15902839 934341 795966..799094 1 NC_003098.1 Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 799094 dnaE 934341 dnaE Streptococcus pneumoniae R6 DNA polymerase III DnaE NP_358389.1 795966 D 171101 CDS NP_358390.1 15902840 934334 799177..800184 1 NC_003098.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 800184 pfkA 934334 pfkA Streptococcus pneumoniae R6 6-phosphofructokinase NP_358390.1 799177 D 171101 CDS NP_358391.1 15902841 934336 800243..801748 1 NC_003098.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 801748 pykF 934336 pykF Streptococcus pneumoniae R6 pyruvate kinase NP_358391.1 800243 D 171101 CDS NP_358393.1 15902843 934343 803555..804427 1 NC_003098.1 hypothetical protein 804427 934343 spr0799 Streptococcus pneumoniae R6 hypothetical protein NP_358393.1 803555 D 171101 CDS NP_358396.1 15902846 934344 805060..805371 1 NC_003098.1 hypothetical protein 805371 934344 spr0802 Streptococcus pneumoniae R6 hypothetical protein NP_358396.1 805060 D 171101 CDS NP_358397.1 15902847 934347 805375..806091 1 NC_003098.1 hypothetical protein 806091 934347 spr0803 Streptococcus pneumoniae R6 hypothetical protein NP_358397.1 805375 D 171101 CDS NP_358398.1 15902848 934349 complement(806221..807036) 1 NC_003098.1 hypothetical protein 807036 934349 spr0804 Streptococcus pneumoniae R6 hypothetical protein NP_358398.1 806221 R 171101 CDS NP_358399.1 15902849 934351 complement(807033..807938) 1 NC_003098.1 hypothetical protein 807938 934351 spr0805 Streptococcus pneumoniae R6 hypothetical protein NP_358399.1 807033 R 171101 CDS NP_358402.1 15902852 934350 809733..811880 1 NC_003098.1 toxin expression transcriptional accessory protein 811880 tex 934350 tex Streptococcus pneumoniae R6 toxin expression transcriptional accessory protein NP_358402.1 809733 D 171101 CDS NP_358403.1 15902853 934348 811867..812316 1 NC_003098.1 hypothetical protein 812316 934348 spr0809 Streptococcus pneumoniae R6 hypothetical protein NP_358403.1 811867 D 171101 CDS NP_358404.1 15902854 934356 812345..812647 1 NC_003098.1 hypothetical protein 812647 934356 spr0810 Streptococcus pneumoniae R6 hypothetical protein NP_358404.1 812345 D 171101 CDS NP_358405.1 15902855 934355 complement(813001..813192) 1 NC_003098.1 hypothetical protein 813192 934355 spr0811 Streptococcus pneumoniae R6 hypothetical protein NP_358405.1 813001 R 171101 CDS NP_358406.1 15902856 934359 813563..814378 1 NC_003098.1 ABC transporter ATP-binding protein 814378 ABC-NBD 934359 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358406.1 813563 D 171101 CDS NP_358407.1 15902857 934353 814380..816368 1 NC_003098.1 ABC transporter permease 816368 ABC-MSD 934353 ABC-MSD Streptococcus pneumoniae R6 ABC transporter permease NP_358407.1 814380 D 171101 CDS NP_358408.1 15902858 934354 complement(816411..817001) 1 NC_003098.1 hypothetical protein 817001 934354 spr0814 Streptococcus pneumoniae R6 hypothetical protein NP_358408.1 816411 R 171101 CDS NP_358409.1 15902859 934360 complement(817081..818001) 1 NC_003098.1 transposase 818001 934360 spr0815 Streptococcus pneumoniae R6 transposase NP_358409.1 817081 R 171101 CDS NP_358410.1 15902860 934357 818663..820138 1 NC_003098.1 lysine decarboxylase 820138 cad 934357 cad Streptococcus pneumoniae R6 lysine decarboxylase NP_358410.1 818663 D 171101 CDS NP_358413.1 15902863 934362 821075..821935 1 NC_003098.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 821935 speE 934362 speE Streptococcus pneumoniae R6 spermidine synthase NP_358413.1 821075 D 171101 CDS NP_358414.1 15902864 934369 821932..823191 1 NC_003098.1 hypothetical protein 823191 934369 spr0820 Streptococcus pneumoniae R6 hypothetical protein NP_358414.1 821932 D 171101 CDS NP_358415.1 15902865 934364 823191..824318 1 NC_003098.1 carboxynorspermidine decarboxylase 824318 nspC 934364 nspC Streptococcus pneumoniae R6 carboxynorspermidine decarboxylase NP_358415.1 823191 D 171101 CDS NP_358416.1 15902866 934363 824315..825400 1 NC_003098.1 catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis; agmatine deiminase 825400 934363 spr0822 Streptococcus pneumoniae R6 agmatine deiminase NP_358416.1 824315 D 171101 CDS NP_358417.1 15902867 934377 825410..826285 1 NC_003098.1 beta-alanine synthase or beta-ureidopropionase 826285 but 934377 but Streptococcus pneumoniae R6 beta-alanine synthase or beta-ureidopropionase NP_358417.1 825410 D 171101 CDS NP_358418.1 15902868 934365 complement(826466..827275) 1 NC_003098.1 Cof family protein 827275 934365 spr0824 Streptococcus pneumoniae R6 Cof family protein NP_358418.1 826466 R 171101 CDS NP_358419.1 15902869 934366 827547..827768 1 NC_003098.1 hypothetical protein 827768 934366 spr0825 Streptococcus pneumoniae R6 hypothetical protein NP_358419.1 827547 D 171101 CDS NP_358420.1 15902870 934373 827822..828493 1 NC_003098.1 hypothetical protein 828493 934373 spr0826 Streptococcus pneumoniae R6 hypothetical protein NP_358420.1 827822 D 171101 CDS NP_358422.1 15902872 934370 828735..829643 1 NC_003098.1 regulatory function on capsule expression in group B streptococci 829643 cpsY 934370 cpsY Streptococcus pneumoniae R6 regulatory function on capsule expression in group B streptococci NP_358422.1 828735 D 171101 CDS NP_358423.1 15902873 934374 829640..830101 1 NC_003098.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 830101 lspA 934374 lspA Streptococcus pneumoniae R6 lipoprotein signal peptidase NP_358423.1 829640 D 171101 CDS NP_358424.1 15902874 934371 830091..830978 1 NC_003098.1 ribosomal large subunit pseudouridine synthase D 830978 rluD 934371 rluD Streptococcus pneumoniae R6 ribosomal large subunit pseudouridine synthase D NP_358424.1 830091 D 171101 CDS NP_358425.1 15902875 934372 830981..832864 1 NC_003098.1 choline binding protein E 832864 lytD 934372 lytD Streptococcus pneumoniae R6 choline binding protein E NP_358425.1 830981 D 171101 CDS NP_358426.1 15902876 934389 832944..834074 1 NC_003098.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 834074 proB 934389 proB Streptococcus pneumoniae R6 gamma-glutamyl kinase NP_358426.1 832944 D 171101 CDS NP_358427.1 15902877 934375 834084..835346 1 NC_003098.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 835346 proA 934375 proA Streptococcus pneumoniae R6 gamma-glutamyl phosphate reductase NP_358427.1 834084 D 171101 CDS NP_358428.1 15902878 934378 835350..836147 1 NC_003098.1 pyrroline-5-carboxylate reductase 836147 proC 934378 proC Streptococcus pneumoniae R6 pyrroline-5-carboxylate reductase NP_358428.1 835350 D 171101 CDS NP_358429.1 15902879 934382 836263..836901 1 NC_003098.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 836901 tmk 934382 tmk Streptococcus pneumoniae R6 thymidylate kinase NP_358429.1 836263 D 171101 CDS NP_358430.1 15902880 934380 836898..837788 1 NC_003098.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 837788 holB 934380 holB Streptococcus pneumoniae R6 DNA polymerase III subunit delta' NP_358430.1 836898 D 171101 CDS NP_358431.1 15902881 934376 837801..838145 1 NC_003098.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 838145 934376 spr0837 Streptococcus pneumoniae R6 DNA replication intiation control protein YabA NP_358431.1 837801 D 171101 CDS NP_358432.1 15902882 934385 838148..839017 1 NC_003098.1 hypothetical protein 839017 934385 spr0838 Streptococcus pneumoniae R6 hypothetical protein NP_358432.1 838148 D 171101 CDS NP_358433.1 15902883 934379 839217..839762 1 NC_003098.1 hypothetical protein 839762 934379 spr0839 Streptococcus pneumoniae R6 hypothetical protein NP_358433.1 839217 D 171101 CDS NP_358434.1 15902884 934381 839871..840518 1 NC_003098.1 hypothetical protein 840518 934381 spr0840 Streptococcus pneumoniae R6 hypothetical protein NP_358434.1 839871 D 171101 CDS NP_358435.1 15902885 934387 complement(840507..840896) 1 NC_003098.1 tranposase 840896 IS1381 934387 IS1381 Streptococcus pneumoniae R6 tranposase NP_358435.1 840507 R 171101 CDS NP_358436.1 15902886 934383 complement(840922..841311) 1 NC_003098.1 tranposase 841311 IS1381 934383 IS1381 Streptococcus pneumoniae R6 tranposase NP_358436.1 840922 R 171101 CDS NP_358438.1 15902888 934391 841805..843139 1 NC_003098.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 843139 gidA 934391 gidA Streptococcus pneumoniae R6 tRNA (uracil-5-)-methyltransferase Gid NP_358438.1 841805 D 171101 CDS NP_358439.1 15902889 934386 843217..843960 1 NC_003098.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 843960 pyrH 934386 pyrH Streptococcus pneumoniae R6 uridylate kinase NP_358439.1 843217 D 171101 CDS NP_358440.1 15902890 934401 843969..844526 1 NC_003098.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 844526 frr 934401 frr Streptococcus pneumoniae R6 ribosome recycling factor NP_358440.1 843969 D 171101 CDS NP_358441.1 15902891 934394 844547..845440 1 NC_003098.1 hypothetical protein 845440 934394 spr0847 Streptococcus pneumoniae R6 hypothetical protein NP_358441.1 844547 D 171101 CDS NP_358442.1 15902892 934388 845449..845664 1 NC_003098.1 hypothetical protein 845664 934388 spr0848 Streptococcus pneumoniae R6 hypothetical protein NP_358442.1 845449 D 171101 CDS NP_358443.1 15902893 934390 845750..846718 1 NC_003098.1 PhoH family protein 846718 phoL 934390 phoL Streptococcus pneumoniae R6 PhoH family protein NP_358443.1 845750 D 171101 CDS NP_358444.1 15902894 934396 846911..847411 1 NC_003098.1 hypothetical protein 847411 934396 spr0850 Streptococcus pneumoniae R6 hypothetical protein NP_358444.1 846911 D 171101 CDS NP_358449.1 15902899 934395 849329..849898 1 NC_003098.1 Probable acetyl transferase; hypothetical protein 849898 934395 spr0855 Streptococcus pneumoniae R6 hypothetical protein NP_358449.1 849329 D 171101 CDS NP_358450.1 15902900 934400 849966..850616 1 NC_003098.1 Competence induced; comE-like protein A also known as CilE; DNA uptake by homology; competence protein CelA 850616 celA 934400 celA Streptococcus pneumoniae R6 competence protein CelA NP_358450.1 849966 D 171101 CDS NP_358451.1 15902901 934397 850600..852840 1 NC_003098.1 Competence induced; comE-like protein B; DNA uptake by homology; competence protein CelB 852840 celB 934397 celB Streptococcus pneumoniae R6 competence protein CelB NP_358451.1 850600 D 171101 CDS NP_358454.1 15902904 934399 853830..855011 1 NC_003098.1 hypothetical protein 855011 934399 spr0860 Streptococcus pneumoniae R6 hypothetical protein NP_358454.1 853830 D 171101 CDS NP_358455.1 15902905 934403 855261..855848 1 NC_003098.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 855848 infC 934403 infC Streptococcus pneumoniae R6 translation initiation factor IF-3 NP_358455.1 855261 D 171101 CDS NP_358456.1 15902906 933877 855881..856081 1 NC_003098.1 50S ribosomal protein L35 856081 rpmI 933877 rpmI Streptococcus pneumoniae R6 50S ribosomal protein L35 NP_358456.1 855881 D 171101 CDS NP_358457.1 15902907 934411 856133..856492 1 NC_003098.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 856492 rplT 934411 rplT Streptococcus pneumoniae R6 50S ribosomal protein L20 NP_358457.1 856133 D 171101 CDS NP_358458.1 15902908 934408 856499..856930 1 NC_003098.1 lactoylglutathione lyase 856930 lguL 934408 lguL Streptococcus pneumoniae R6 lactoylglutathione lyase NP_358458.1 856499 D 171101 CDS NP_358459.1 15902909 933866 857180..857980 1 NC_003098.1 responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+); dihydroorotate dehydrogenase electron transfer subunit 857980 pyrDII 933866 pyrDII Streptococcus pneumoniae R6 dihydroorotate dehydrogenase electron transfer subunit NP_358459.1 857180 D 171101 CDS NP_358460.2 161410749 934407 857991..858929 1 NC_003098.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 858929 pyrD 934407 pyrD Streptococcus pneumoniae R6 dihydroorotate dehydrogenase 1B NP_358460.2 857991 D 171101 CDS NP_358461.1 15902911 934406 858971..861136 1 NC_003098.1 endo-beta-N-acetylglucosaminidase 861136 lytB 934406 lytB Streptococcus pneumoniae R6 endo-beta-N-acetylglucosaminidase NP_358461.1 858971 D 171101 CDS NP_358462.1 15902912 933098 complement(861197..862879) 1 NC_003098.1 adherence and virulence protein A 862879 flpA 933098 flpA Streptococcus pneumoniae R6 adherence and virulence protein A NP_358462.1 861197 R 171101 CDS NP_358463.1 15902913 934173 862957..863454 1 NC_003098.1 metalloprotease 863454 934173 spr0869 Streptococcus pneumoniae R6 metalloprotease NP_358463.1 862957 D 171101 CDS NP_358464.1 15902914 933031 863435..863830 1 NC_003098.1 diacylglycerol kinase 863830 dgkA 933031 dgkA Streptococcus pneumoniae R6 diacylglycerol kinase NP_358464.1 863435 D 171101 CDS NP_358465.1 15902915 933913 863847..864746 1 NC_003098.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 864746 era 933913 era Streptococcus pneumoniae R6 GTP-binding protein Era NP_358465.1 863847 D 171101 CDS NP_358466.1 15902916 933206 864795..865619 1 NC_003098.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 865619 mutM 933206 mutM Streptococcus pneumoniae R6 formamidopyrimidine-DNA glycosylase NP_358466.1 864795 D 171101 CDS NP_358467.1 15902917 932960 865592..866224 1 NC_003098.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 866224 coaE 932960 coaE Streptococcus pneumoniae R6 dephospho-CoA kinase NP_358467.1 865592 D 171101 CDS NP_358469.1 15902919 933710 866211..867410 1 NC_003098.1 major facilitator superfamily multi-drug resistance efflux pump 867410 pmrA 933710 pmrA Streptococcus pneumoniae R6 major facilitator superfamily multi-drug resistance efflux pump NP_358469.1 866211 D 171101 CDS NP_358470.1 15902920 933739 867410..867559 1 NC_003098.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 867559 rpmG 933739 rpmG Streptococcus pneumoniae R6 50S ribosomal protein L33 NP_358470.1 867410 D 171101 CDS NP_358471.1 15902921 933638 867599..867832 1 NC_003098.1 preprotein translocase subunit SecG 867832 secG 933638 secG Streptococcus pneumoniae R6 preprotein translocase subunit SecG NP_358471.1 867599 D 171101 CDS NP_358472.1 15902922 932871 867934..870288 1 NC_003098.1 exoribonuclease R 870288 rnr 932871 rnr Streptococcus pneumoniae R6 exoribonuclease R NP_358472.1 867934 D 171101 CDS NP_358473.1 15902923 933888 870251..870718 1 NC_003098.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 870718 smpB 933888 smpB Streptococcus pneumoniae R6 SsrA-binding protein NP_358473.1 870251 D 171101 CDS NP_358474.1 15902924 932916 870728..871594 1 NC_003098.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 871594 tehB 932916 tehB Streptococcus pneumoniae R6 tellurite resistance protein TehB NP_358474.1 870728 D 171101 CDS NP_358475.1 15902925 933951 871667..872620 1 NC_003098.1 Competence induced protein A; competence protein CoiA 872620 coiA 933951 coiA Streptococcus pneumoniae R6 competence protein CoiA NP_358475.1 871667 D 171101 CDS NP_358476.1 15902926 933006 872639..874441 1 NC_003098.1 oligoendopeptidase F 874441 pepB 933006 pepB Streptococcus pneumoniae R6 oligoendopeptidase F NP_358476.1 872639 D 171101 CDS NP_358477.1 15902927 933962 874443..875156 1 NC_003098.1 Probable methyltransferase; O-methyltransferase 875156 933962 spr0883 Streptococcus pneumoniae R6 O-methyltransferase NP_358477.1 874443 D 171101 CDS NP_358478.1 15902928 932962 875223..876164 1 NC_003098.1 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase PrsA 876164 prsA 932962 prsA Streptococcus pneumoniae R6 foldase PrsA NP_358478.1 875223 D 171101 CDS NP_358481.1 15902931 933141 complement(877383..878003) 1 NC_003098.1 phosphoglycerate mutase 878003 gpmB 933141 gpmB Streptococcus pneumoniae R6 phosphoglycerate mutase NP_358481.1 877383 R 171101 CDS NP_358482.1 15902932 932797 complement(878003..878485) 1 NC_003098.1 regulatory protein 878485 ebsC 932797 ebsC Streptococcus pneumoniae R6 regulatory protein NP_358482.1 878003 R 171101 CDS NP_358483.1 15902933 932840 complement(878485..879327) 1 NC_003098.1 hypothetical protein 879327 932840 spr0889 Streptococcus pneumoniae R6 hypothetical protein NP_358483.1 878485 R 171101 CDS NP_358484.1 15902934 933046 complement(879422..880222) 1 NC_003098.1 hypothetical protein 880222 933046 spr0890 Streptococcus pneumoniae R6 hypothetical protein NP_358484.1 879422 R 171101 CDS NP_358485.1 15902935 933167 880306..881745 1 NC_003098.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 881745 glmU 933167 glmU Streptococcus pneumoniae R6 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase NP_358485.1 880306 D 171101 CDS NP_358486.1 15902936 932911 881755..882300 1 NC_003098.1 hypothetical protein 882300 932911 spr0892 Streptococcus pneumoniae R6 hypothetical protein NP_358486.1 881755 D 171101 CDS NP_358487.1 15902937 933247 882279..882626 1 NC_003098.1 hypothetical protein 882626 933247 spr0893 Streptococcus pneumoniae R6 hypothetical protein NP_358487.1 882279 D 171101 CDS NP_358488.1 15902938 933030 882643..883335 1 NC_003098.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 883335 pfs 933030 pfs Streptococcus pneumoniae R6 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase NP_358488.1 882643 D 171101 CDS NP_358489.1 15902939 932987 883412..883903 1 NC_003098.1 hypothetical protein 883903 932987 spr0895 Streptococcus pneumoniae R6 hypothetical protein NP_358489.1 883412 D 171101 CDS NP_358490.1 15902940 934055 883965..884591 1 NC_003098.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 884591 dnaQ 934055 dnaQ Streptococcus pneumoniae R6 DNA polymerase III subunit epsilon NP_358490.1 883965 D 171101 CDS NP_358491.1 15902941 933351 884594..886363 1 NC_003098.1 hypothetical protein 886363 933351 spr0897 Streptococcus pneumoniae R6 hypothetical protein NP_358491.1 884594 D 171101 CDS NP_358494.1 15902944 933391 887384..887584 1 NC_003098.1 hypothetical protein 887584 933391 spr0900 Streptococcus pneumoniae R6 hypothetical protein NP_358494.1 887384 D 171101 CDS NP_358496.1 15902946 933860 887626..888030 1 NC_003098.1 hypothetical protein 888030 933860 spr0902 Streptococcus pneumoniae R6 hypothetical protein NP_358496.1 887626 D 171101 CDS NP_358497.1 15902947 934067 888261..888968 1 NC_003098.1 cytochrome c-type biogenesis protein 888968 ccdA 934067 ccdA Streptococcus pneumoniae R6 cytochrome c-type biogenesis protein NP_358497.1 888261 D 171101 CDS NP_358498.1 15902948 933921 888961..889536 1 NC_003098.1 Similar to thiol:disulfide interchange protein; hypothetical protein 889536 933921 spr0904 Streptococcus pneumoniae R6 hypothetical protein NP_358498.1 888961 D 171101 CDS NP_358499.1 15902949 933721 889898..891301 1 NC_003098.1 cationic amino acid transporter 891301 yfnA 933721 yfnA Streptococcus pneumoniae R6 cationic amino acid transporter NP_358499.1 889898 D 171101 CDS NP_358500.1 15902950 932947 891426..892361 1 NC_003098.1 adhesion lipoprotein 892361 lmb 932947 lmb Streptococcus pneumoniae R6 adhesion lipoprotein NP_358500.1 891426 D 171101 CDS NP_358501.1 15902951 933304 892369..894930 1 NC_003098.1 pneumococcal histidine triad protein D 894930 phtD 933304 phtD Streptococcus pneumoniae R6 pneumococcal histidine triad protein D NP_358501.1 892369 D 171101 CDS NP_358502.1 15902952 933256 895140..898259 1 NC_003098.1 pneumococcal histidine triad protein E 898259 phtE 933256 phtE Streptococcus pneumoniae R6 pneumococcal histidine triad protein E NP_358502.1 895140 D 171101 CDS NP_358506.1 15902956 933755 900059..900688 1 NC_003098.1 hypothetical protein 900688 933755 spr0912 Streptococcus pneumoniae R6 hypothetical protein NP_358506.1 900059 D 171101 CDS NP_358507.1 15902957 933013 complement(900731..901951) 1 NC_003098.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 901951 pepT 933013 pepT Streptococcus pneumoniae R6 peptidase T NP_358507.1 900731 R 171101 CDS NP_358508.1 15902958 933500 902106..903200 1 NC_003098.1 ferrochelatase 903200 hemH 933500 hemH Streptococcus pneumoniae R6 ferrochelatase NP_358508.1 902106 D 171101 CDS NP_358509.1 15902959 932884 complement(903242..903619) 1 NC_003098.1 large conductance mechanosensitive channel protein MscL 903619 mscL 932884 mscL Streptococcus pneumoniae R6 large conductance mechanosensitive channel protein MscL NP_358509.1 903242 R 171101 CDS NP_358510.1 15902960 934062 complement(903701..904132) 1 NC_003098.1 GtrA family protein 904132 mesH 934062 mesH Streptococcus pneumoniae R6 GtrA family protein NP_358510.1 903701 R 171101 CDS NP_358511.1 15902961 932932 904183..904764 1 NC_003098.1 hypothetical protein 904764 ccl 932932 ccl Streptococcus pneumoniae R6 hypothetical protein NP_358511.1 904183 D 171101 CDS NP_358512.1 15902962 933797 905279..906355 1 NC_003098.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 906355 asd 933797 asd Streptococcus pneumoniae R6 aspartate-semialdehyde dehydrogenase NP_358512.1 905279 D 171101 CDS NP_358513.1 15902963 932822 906411..907346 1 NC_003098.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 907346 dapA 932822 dapA Streptococcus pneumoniae R6 dihydrodipicolinate synthase NP_358513.1 906411 D 171101 CDS NP_358514.2 161410748 933044 complement(907393..908766) 1 NC_003098.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 908766 trmE 933044 trmE Streptococcus pneumoniae R6 tRNA modification GTPase TrmE NP_358514.2 907393 R 171101 CDS NP_358515.1 15902965 933810 complement(908903..909085) 1 NC_003098.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 909085 xylH 933810 xylH Streptococcus pneumoniae R6 4-oxalocrotonate tautomerase NP_358515.1 908903 R 171101 CDS NP_358516.1 15902966 933593 909208..909807 1 NC_003098.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 909807 tdk 933593 tdk Streptococcus pneumoniae R6 thymidine kinase NP_358516.1 909208 D 171101 CDS NP_358517.1 15902967 933780 909797..910276 1 NC_003098.1 spermine/spermidine acetyltransferase 910276 bltD 933780 bltD Streptococcus pneumoniae R6 spermine/spermidine acetyltransferase NP_358517.1 909797 D 171101 CDS NP_358518.1 15902968 933019 910286..911365 1 NC_003098.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 911365 prfA 933019 prfA Streptococcus pneumoniae R6 peptide chain release factor 1 NP_358518.1 910286 D 171101 CDS NP_358519.1 15902969 933764 911365..912204 1 NC_003098.1 HemK protein 912204 hemK 933764 hemK Streptococcus pneumoniae R6 HemK protein NP_358519.1 911365 D 171101 CDS NP_358520.1 15902970 933346 912179..912790 1 NC_003098.1 hypothetical protein 912790 933346 spr0926 Streptococcus pneumoniae R6 hypothetical protein NP_358520.1 912179 D 171101 CDS NP_358521.1 15902971 933156 912753..913223 1 NC_003098.1 hypothetical protein 913223 933156 spr0927 Streptococcus pneumoniae R6 hypothetical protein NP_358521.1 912753 D 171101 CDS NP_358522.1 15902972 933588 913285..914541 1 NC_003098.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 914541 glyA 933588 glyA Streptococcus pneumoniae R6 serine hydroxymethyltransferase NP_358522.1 913285 D 171101 CDS NP_358523.1 15902973 933203 914516..915523 1 NC_003098.1 hypothetical protein 915523 933203 spr0929 Streptococcus pneumoniae R6 hypothetical protein NP_358523.1 914516 D 171101 CDS NP_358524.1 15902974 933699 915523..916137 1 NC_003098.1 RAS-related protein; hypothetical protein 916137 933699 spr0930 Streptococcus pneumoniae R6 hypothetical protein NP_358524.1 915523 D 171101 CDS NP_358525.1 15902975 933174 916211..917185 1 NC_003098.1 hypothetical protein 917185 933174 spr0931 Streptococcus pneumoniae R6 hypothetical protein NP_358525.1 916211 D 171101 CDS NP_358526.1 15902976 933763 917259..918890 1 NC_003098.1 Similar to RNA methyltransferase; hypothetical protein 918890 933763 spr0932 Streptococcus pneumoniae R6 hypothetical protein NP_358526.1 917259 D 171101 CDS YP_008719803.1 555247349 17374508 919089..919382 1 NC_003098.1 hypothetical protein 919382 17374508 spr0932a Streptococcus pneumoniae R6 hypothetical protein YP_008719803.1 919089 D 171101 CDS NP_358527.1 15902977 933497 919628..919846 1 NC_003098.1 hypothetical protein 919846 933497 spr0933 Streptococcus pneumoniae R6 hypothetical protein NP_358527.1 919628 D 171101 CDS NP_358528.1 15902978 933737 920239..921264 1 NC_003098.1 iron-compound ABC transporter substrate-binding protein 921264 ABC-SBP 933737 ABC-SBP Streptococcus pneumoniae R6 iron-compound ABC transporter substrate-binding protein NP_358528.1 920239 D 171101 CDS NP_358529.1 15902979 932842 921242..922261 1 NC_003098.1 iron-compound ABC transporter permease 922261 ABC-MSP 932842 ABC-MSP Streptococcus pneumoniae R6 iron-compound ABC transporter permease NP_358529.1 921242 D 171101 CDS NP_358530.1 15902980 933342 922261..923268 1 NC_003098.1 iron-compound ABC transporter permease 923268 ABC-MSP 933342 ABC-MSP Streptococcus pneumoniae R6 iron-compound ABC transporter permease NP_358530.1 922261 D 171101 CDS NP_358532.1 15902982 933605 923268..924062 1 NC_003098.1 iron-compound ABC transporter ATP-binding protein 924062 ABC-NBD 933605 ABC-NBD Streptococcus pneumoniae R6 iron-compound ABC transporter ATP-binding protein NP_358532.1 923268 D 171101 CDS NP_358533.1 15902983 933248 924630..924839 1 NC_003098.1 hypothetical protein 924839 933248 spr0939 Streptococcus pneumoniae R6 hypothetical protein NP_358533.1 924630 D 171101 CDS NP_358534.1 15902984 933805 924964..925119 1 NC_003098.1 hypothetical protein 925119 933805 spr0940 Streptococcus pneumoniae R6 hypothetical protein NP_358534.1 924964 D 171101 CDS NP_358535.1 15902985 933415 925803..925964 1 NC_003098.1 hypothetical protein 925964 933415 spr0941 Streptococcus pneumoniae R6 hypothetical protein NP_358535.1 925803 D 171101 CDS NP_358536.1 15902986 933208 926056..927735 1 NC_003098.1 hypothetical protein 927735 ccrB 933208 ccrB Streptococcus pneumoniae R6 hypothetical protein NP_358536.1 926056 D 171101 CDS NP_358537.1 15902987 934059 927958..928569 1 NC_003098.1 hypothetical protein 928569 934059 spr0943 Streptococcus pneumoniae R6 hypothetical protein NP_358537.1 927958 D 171101 CDS NP_358539.1 15902989 933843 929141..929956 1 NC_003098.1 hypothetical protein 929956 933843 spr0945 Streptococcus pneumoniae R6 hypothetical protein NP_358539.1 929141 D 171101 CDS NP_358540.1 15902990 933884 929956..930810 1 NC_003098.1 hydrolase 930810 933884 spr0946 Streptococcus pneumoniae R6 hydrolase NP_358540.1 929956 D 171101 CDS NP_358541.1 15902991 933202 930871..931806 1 NC_003098.1 hypothetical protein 931806 933202 spr0947 Streptococcus pneumoniae R6 hypothetical protein NP_358541.1 930871 D 171101 CDS NP_358542.1 15902992 933869 931945..933708 1 NC_003098.1 neopullulanase 933708 nplT 933869 nplT Streptococcus pneumoniae R6 neopullulanase NP_358542.1 931945 D 171101 CDS NP_358545.1 15902995 932930 934826..935359 1 NC_003098.1 transcriptional regulator 935359 932930 spr0951 Streptococcus pneumoniae R6 transcriptional regulator NP_358545.1 934826 D 171101 CDS NP_358546.1 15902996 932821 935359..936120 1 NC_003098.1 hypothetical protein 936120 932821 spr0952 Streptococcus pneumoniae R6 hypothetical protein NP_358546.1 935359 D 171101 CDS NP_358549.1 15902999 932940 938136..938495 1 NC_003098.1 Hypothetical protein in TN5252; Tn5252, ORF 10 protein 938495 932940 spr0955 Streptococcus pneumoniae R6 Tn5252, ORF 10 protein NP_358549.1 938136 D 171101 CDS NP_358550.1 15903000 933068 938505..938834 1 NC_003098.1 Tn5252, ORF 9 protein 938834 933068 spr0956 Streptococcus pneumoniae R6 Tn5252, ORF 9 protein NP_358550.1 938505 D 171101 CDS NP_358553.1 15903003 933242 940146..940742 1 NC_003098.1 hypothetical protein 940742 933242 spr0959 Streptococcus pneumoniae R6 hypothetical protein NP_358553.1 940146 D 171101 CDS NP_358554.1 15903004 933784 complement(940787..941641) 1 NC_003098.1 positive transcriptional regulator MutR 941641 mutR 933784 mutR Streptococcus pneumoniae R6 positive transcriptional regulator MutR NP_358554.1 940787 R 171101 CDS NP_358555.1 15903005 933215 941893..943188 1 NC_003098.1 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase 943188 rffD 933215 rffD Streptococcus pneumoniae R6 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase NP_358555.1 941893 D 171101 CDS NP_358556.1 15903006 933584 943148..943798 1 NC_003098.1 hypothetical protein 943798 933584 spr0962 Streptococcus pneumoniae R6 hypothetical protein NP_358556.1 943148 D 171101 CDS NP_358557.1 15903007 933374 943808..944590 1 NC_003098.1 hypothetical protein 944590 933374 spr0963 Streptococcus pneumoniae R6 hypothetical protein NP_358557.1 943808 D 171101 CDS NP_358558.1 15903008 933298 944613..946505 1 NC_003098.1 hypothetical protein 946505 933298 spr0964 Streptococcus pneumoniae R6 hypothetical protein NP_358558.1 944613 D 171101 CDS NP_358559.1 15903009 934070 946534..947640 1 NC_003098.1 hypothetical protein 947640 934070 spr0965 Streptococcus pneumoniae R6 hypothetical protein NP_358559.1 946534 D 171101 CDS NP_358560.1 15903010 933093 947648..948958 1 NC_003098.1 Probable acid-CoA ligase; hypothetical protein 948958 933093 spr0966 Streptococcus pneumoniae R6 hypothetical protein NP_358560.1 947648 D 171101 CDS NP_358561.1 15903011 933966 948960..950183 1 NC_003098.1 hypothetical protein 950183 933966 spr0967 Streptococcus pneumoniae R6 hypothetical protein NP_358561.1 948960 D 171101 CDS NP_358562.1 15903012 933230 950173..951123 1 NC_003098.1 hypothetical protein 951123 933230 spr0968 Streptococcus pneumoniae R6 hypothetical protein NP_358562.1 950173 D 171101 CDS NP_358563.1 15903013 933819 951138..952337 1 NC_003098.1 nikkomycin biosynthesis protein, carboxylase 952337 nikS 933819 nikS Streptococcus pneumoniae R6 nikkomycin biosynthesis protein, carboxylase NP_358563.1 951138 D 171101 CDS NP_358564.1 15903014 933493 952356..953000 1 NC_003098.1 Probable acetyltransferase; hypothetical protein 953000 933493 spr0970 Streptococcus pneumoniae R6 hypothetical protein NP_358564.1 952356 D 171101 CDS NP_358565.1 15903015 933922 953383..954594 1 NC_003098.1 macolide ABC transporter permease 954594 mefE 933922 mefE Streptococcus pneumoniae R6 macolide ABC transporter permease NP_358565.1 953383 D 171101 CDS NP_358566.1 15903016 933427 955253..955474 1 NC_003098.1 repressor protein; hypothetical protein 955474 933427 spr0972 Streptococcus pneumoniae R6 hypothetical protein NP_358566.1 955253 D 171101 CDS NP_358567.1 15903017 933970 956376..957605 1 NC_003098.1 cell division protein FtsW 957605 ftsW 933970 ftsW Streptococcus pneumoniae R6 cell division protein FtsW NP_358567.1 956376 D 171101 CDS NP_358568.1 15903018 932953 957625..960321 1 NC_003098.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 960321 ppc 932953 ppc Streptococcus pneumoniae R6 phosphoenolpyruvate carboxylase NP_358568.1 957625 D 171101 CDS NP_358569.1 15903019 933181 960704..961738 1 NC_003098.1 hypothetical protein 961738 ABC-SBP 933181 ABC-SBP Streptococcus pneumoniae R6 hypothetical protein NP_358569.1 960704 D 171101 CDS NP_358570.1 15903020 933290 961807..962673 1 NC_003098.1 ABC transporter permease 962673 ABC-MSP 933290 ABC-MSP Streptococcus pneumoniae R6 ABC transporter permease NP_358570.1 961807 D 171101 CDS NP_358571.1 15903021 933967 962670..963428 1 NC_003098.1 ABC transporter ATP-binding protein 963428 ABC-NBD 933967 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358571.1 962670 D 171101 CDS NP_358572.1 15903022 933419 963503..965278 1 NC_003098.1 synthesizes RNA primers at the replication forks; DNA primase 965278 dnaG 933419 dnaG Streptococcus pneumoniae R6 DNA primase NP_358572.1 963503 D 171101 CDS NP_358573.1 15903023 933267 965281..966390 1 NC_003098.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 966390 rpoD 933267 rpoD Streptococcus pneumoniae R6 RNA polymerase sigma factor RpoD NP_358573.1 965281 D 171101 CDS NP_358574.1 15903024 933232 966371..966733 1 NC_003098.1 hypothetical protein 966733 933232 spr0980 Streptococcus pneumoniae R6 hypothetical protein NP_358574.1 966371 D 171101 CDS NP_358575.1 15903025 933377 966767..967891 1 NC_003098.1 glycosyl transferase CpoA 967891 cpoA 933377 cpoA Streptococcus pneumoniae R6 glycosyl transferase CpoA NP_358575.1 966767 D 171101 CDS NP_358576.1 15903026 932928 967907..969232 1 NC_003098.1 Probable hexosyltransferase; glycosyl transferase 969232 932928 spr0982 Streptococcus pneumoniae R6 glycosyl transferase NP_358576.1 967907 D 171101 CDS NP_358577.1 15903027 933885 969263..969439 1 NC_003098.1 hypothetical protein 969439 933885 spr0983 Streptococcus pneumoniae R6 hypothetical protein NP_358577.1 969263 D 171101 CDS NP_358578.2 161410747 933276 969702..971006 1 NC_003098.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 971006 obgE 933276 obgE Streptococcus pneumoniae R6 GTPase ObgE NP_358578.2 969702 D 171101 CDS NP_358579.1 15903029 933219 971016..971174 1 NC_003098.1 hypothetical protein 971174 933219 spr0985 Streptococcus pneumoniae R6 hypothetical protein NP_358579.1 971016 D 171101 CDS NP_358582.1 15903032 932860 complement(972009..972563) 1 NC_003098.1 transposase 972563 IS1167 932860 IS1167 Streptococcus pneumoniae R6 transposase NP_358582.1 972009 R 171101 CDS NP_358583.1 15903033 933272 973796..975055 1 NC_003098.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 975055 murZ 933272 murZ Streptococcus pneumoniae R6 UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_358583.1 973796 D 171101 CDS NP_358584.1 15903034 932825 975065..975622 1 NC_003098.1 Similar to alanine acetyl transferase; hypothetical protein 975622 932825 spr0990 Streptococcus pneumoniae R6 hypothetical protein NP_358584.1 975065 D 171101 CDS NP_358585.1 15903035 933905 975615..976892 1 NC_003098.1 hypothetical protein 976892 933905 spr0991 Streptococcus pneumoniae R6 hypothetical protein NP_358585.1 975615 D 171101 CDS NP_358586.1 15903036 932841 976908..977768 1 NC_003098.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 977768 map 932841 map Streptococcus pneumoniae R6 methionine aminopeptidase NP_358586.1 976908 D 171101 CDS NP_358587.1 15903037 933862 977840..978547 1 NC_003098.1 hypothetical protein 978547 933862 spr0993 Streptococcus pneumoniae R6 hypothetical protein NP_358587.1 977840 D 171101 CDS NP_358588.1 15903038 933283 978562..978951 1 NC_003098.1 tranposase 978951 IS1381 933283 IS1381 Streptococcus pneumoniae R6 tranposase NP_358588.1 978562 D 171101 CDS NP_358589.1 15903039 932805 979142..981433 1 NC_003098.1 ATP-dependent DNA helicase PcrA 981433 pcrA 932805 pcrA Streptococcus pneumoniae R6 ATP-dependent DNA helicase PcrA NP_358589.1 979142 D 171101 CDS NP_358590.1 15903040 934080 981461..982156 1 NC_003098.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 982156 radC 934080 radC Streptococcus pneumoniae R6 DNA repair protein RadC NP_358590.1 981461 D 171101 CDS NP_358591.1 15903041 934076 complement(982153..982842) 1 NC_003098.1 Probable amidotransferase; hypothetical protein 982842 934076 spr0997 Streptococcus pneumoniae R6 hypothetical protein NP_358591.1 982153 R 171101 CDS NP_358592.1 15903042 934078 complement(982860..983501) 1 NC_003098.1 modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex 983501 934078 spr0998 Streptococcus pneumoniae R6 redox-sensing transcriptional repressor Rex NP_358592.1 982860 R 171101 CDS NP_358593.1 15903043 934167 complement(983584..983835) 1 NC_003098.1 hypothetical protein 983835 934167 spr0999 Streptococcus pneumoniae R6 hypothetical protein NP_358593.1 983584 R 171101 CDS NP_358594.1 15903044 934034 complement(983807..984154) 1 NC_003098.1 hypothetical protein 984154 934034 spr1000 Streptococcus pneumoniae R6 hypothetical protein NP_358594.1 983807 R 171101 CDS NP_358595.1 15903045 934171 complement(984159..985274) 1 NC_003098.1 pyridoxal-phosphate dependent aminotransferase 985274 nifS 934171 nifS Streptococcus pneumoniae R6 pyridoxal-phosphate dependent aminotransferase NP_358595.1 984159 R 171101 CDS NP_358596.1 15903046 932850 complement(985284..986243) 1 NC_003098.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 986243 prs 932850 prs Streptococcus pneumoniae R6 ribose-phosphate pyrophosphokinase NP_358596.1 985284 R 171101 CDS NP_358597.1 15903047 934074 complement(986356..986925) 1 NC_003098.1 hypothetical protein 986925 934074 spr1003 Streptococcus pneumoniae R6 hypothetical protein NP_358597.1 986356 R 171101 CDS NP_358598.1 15903048 934631 987053..987724 1 NC_003098.1 GTP pyrophosphokinase 987724 934631 spr1004 Streptococcus pneumoniae R6 GTP pyrophosphokinase NP_358598.1 987053 D 171101 CDS NP_358599.1 15903049 934633 987696..988526 1 NC_003098.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 988526 ppnK 934633 ppnK Streptococcus pneumoniae R6 inorganic polyphosphate/ATP-NAD kinase NP_358599.1 987696 D 171101 CDS NP_358600.1 15903050 933234 988523..989419 1 NC_003098.1 23S rRNA pseudouridine synthase 989419 rluD 933234 rluD Streptococcus pneumoniae R6 23S rRNA pseudouridine synthase NP_358600.1 988523 D 171101 CDS NP_358601.1 15903051 933854 989463..990437 1 NC_003098.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 990437 eutD 933854 eutD Streptococcus pneumoniae R6 phosphotransacetylase NP_358601.1 989463 D 171101 CDS NP_358603.1 15903053 933833 complement(991498..992016) 1 NC_003098.1 transposase 992016 IS1167 933833 IS1167 Streptococcus pneumoniae R6 transposase NP_358603.1 991498 R 171101 CDS NP_358604.1 15903054 933771 complement(992198..992497) 1 NC_003098.1 hypothetical protein 992497 933771 spr1010 Streptococcus pneumoniae R6 hypothetical protein NP_358604.1 992198 R 171101 CDS NP_358605.1 15903055 933761 992899..993603 1 NC_003098.1 hypothetical protein 993603 933761 spr1011 Streptococcus pneumoniae R6 hypothetical protein NP_358605.1 992899 D 171101 CDS NP_358606.1 15903056 933955 993785..994099 1 NC_003098.1 50S ribosomal protein L21 994099 rplU 933955 rplU Streptococcus pneumoniae R6 50S ribosomal protein L21 NP_358606.1 993785 D 171101 CDS NP_358607.1 15903057 933790 994115..994459 1 NC_003098.1 hypothetical protein 994459 933790 spr1013 Streptococcus pneumoniae R6 hypothetical protein NP_358607.1 994115 D 171101 CDS NP_358608.1 15903058 934115 994500..994769 1 NC_003098.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 994769 rpmA 934115 rpmA Streptococcus pneumoniae R6 50S ribosomal protein L27 NP_358608.1 994500 D 171101 CDS NP_358611.1 15903061 934162 995722..996639 1 NC_003098.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 996639 mreA 934162 mreA Streptococcus pneumoniae R6 bifunctional riboflavin kinase/FMN adenylyltransferase NP_358611.1 995722 D 171101 CDS NP_358612.1 15903062 934083 complement(996732..997580) 1 NC_003098.1 hypothetical protein 997580 934083 spr1018 Streptococcus pneumoniae R6 hypothetical protein NP_358612.1 996732 R 171101 CDS NP_358613.1 15903063 934107 997722..998561 1 NC_003098.1 Similar to Bacillus subtilis DegV protein; hypothetical protein 998561 934107 spr1019 Streptococcus pneumoniae R6 hypothetical protein NP_358613.1 997722 D 171101 CDS NP_358614.1 15903064 934105 998667..998942 1 NC_003098.1 DNA-binding protein HU 998942 hlpA 934105 hlpA Streptococcus pneumoniae R6 DNA-binding protein HU NP_358614.1 998667 D 171101 CDS NP_358615.1 15903065 934100 999368..1001269 1 NC_003098.1 ABC transporter ATP-binding protein 1001269 ABC-NBD 934100 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358615.1 999368 D 171101 CDS NP_358616.1 15903066 934159 1001242..1002135 1 NC_003098.1 transcriptional regulator MutR 1002135 rggD 934159 rggD Streptococcus pneumoniae R6 transcriptional regulator MutR NP_358616.1 1001242 D 171101 CDS NP_358617.1 15903067 932990 1002215..1003393 1 NC_003098.1 macrolide ABC transporter permease 1003393 ABC-MSP 932990 ABC-MSP Streptococcus pneumoniae R6 macrolide ABC transporter permease NP_358617.1 1002215 D 171101 CDS NP_358618.1 15903068 933694 1003486..1005444 1 NC_003098.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1005444 ligA 933694 ligA Streptococcus pneumoniae R6 NAD-dependent DNA ligase LigA NP_358618.1 1003486 D 171101 CDS NP_358619.1 15903069 932903 1005556..1007835 1 NC_003098.1 thermostable pullulanase 1007835 pulI 932903 pulI Streptococcus pneumoniae R6 thermostable pullulanase NP_358619.1 1005556 D 171101 CDS NP_358622.1 15903072 933338 1008379..1009803 1 NC_003098.1 glyceraldehyde-3-phosphate dehydrogenase 1009803 gapN 933338 gapN Streptococcus pneumoniae R6 glyceraldehyde-3-phosphate dehydrogenase NP_358622.1 1008379 D 171101 CDS NP_358623.1 15903073 933336 1010268..1012196 1 NC_003098.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 1012196 glgB 933336 glgB Streptococcus pneumoniae R6 glycogen branching protein NP_358623.1 1010268 D 171101 CDS NP_358624.1 15903074 934106 1012186..1013328 1 NC_003098.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1013328 glgC 934106 glgC Streptococcus pneumoniae R6 glucose-1-phosphate adenylyltransferase NP_358624.1 1012186 D 171101 CDS NP_358625.1 15903075 934104 1013318..1014457 1 NC_003098.1 required for glycogen biosynthesis 1014457 glgD 934104 glgD Streptococcus pneumoniae R6 required for glycogen biosynthesis NP_358625.1 1013318 D 171101 CDS NP_358626.1 15903076 934118 1014454..1015887 1 NC_003098.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 1015887 glgA 934118 glgA Streptococcus pneumoniae R6 glycogen synthase NP_358626.1 1014454 D 171101 CDS NP_358628.1 15903078 934122 1016588..1017715 1 NC_003098.1 glycerate kinase 1017715 glxK 934122 glxK Streptococcus pneumoniae R6 glycerate kinase NP_358628.1 1016588 D 171101 CDS NP_358629.1 15903079 934154 complement(1017712..1018158) 1 NC_003098.1 hypothetical protein 1018158 934154 spr1035 Streptococcus pneumoniae R6 hypothetical protein NP_358629.1 1017712 R 171101 CDS NP_358630.1 15903080 934109 1018322..1019626 1 NC_003098.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1019626 eno 934109 eno Streptococcus pneumoniae R6 phosphopyruvate hydratase NP_358630.1 1018322 D 171101 CDS NP_358632.1 15903082 934125 complement(1020607..1020975) 1 NC_003098.1 transposase 1020975 transposase_A 934125 transposase_A Streptococcus pneumoniae R6 transposase NP_358632.1 1020607 R 171101 CDS NP_358633.1 15903083 933876 1021482..1024757 1 NC_003098.1 second subunit of major exonuclease 1024757 rexB 933876 rexB Streptococcus pneumoniae R6 second subunit of major exonuclease NP_358633.1 1021482 D 171101 CDS NP_358634.1 15903084 933887 1024754..1028404 1 NC_003098.1 exonuclease RexA 1028404 rexA 933887 rexA Streptococcus pneumoniae R6 exonuclease RexA NP_358634.1 1024754 D 171101 CDS NP_358635.1 15903085 933976 1028574..1029752 1 NC_003098.1 hypothetical protein 1029752 933976 spr1041 Streptococcus pneumoniae R6 hypothetical protein NP_358635.1 1028574 D 171101 CDS NP_358636.1 15903086 933909 1029961..1035852 1 NC_003098.1 immunoglobulin A1 protease 1035852 iga 933909 iga Streptococcus pneumoniae R6 immunoglobulin A1 protease NP_358636.1 1029961 D 171101 CDS NP_358637.1 15903087 933067 1036311..1037162 1 NC_003098.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1037162 rbgA 933067 rbgA Streptococcus pneumoniae R6 ribosomal biogenesis GTPase NP_358637.1 1036311 D 171101 CDS NP_358638.1 15903088 933032 1037149..1037928 1 NC_003098.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1037928 rnhB 933032 rnhB Streptococcus pneumoniae R6 ribonuclease HII NP_358638.1 1037149 D 171101 CDS NP_358639.1 15903089 934627 1037929..1039494 1 NC_003098.1 channel transporter; voltage-gated chloride channel family protein 1039494 934627 spr1045 Streptococcus pneumoniae R6 voltage-gated chloride channel family protein NP_358639.1 1037929 D 171101 CDS NP_358640.1 15903090 934075 1040078..1041148 1 NC_003098.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1041148 xerS 934075 xerS Streptococcus pneumoniae R6 site-specific tyrosine recombinase XerS NP_358640.1 1040078 D 171101 CDS NP_358641.1 15903091 934072 complement(1041221..1042210) 1 NC_003098.1 lipoate-protein ligase 1042210 lplA 934072 lplA Streptococcus pneumoniae R6 lipoate-protein ligase NP_358641.1 1041221 R 171101 CDS NP_358642.1 15903092 934625 complement(1042274..1043977) 1 NC_003098.1 dihydrolipoamide dehydrogenase 1043977 acoL 934625 acoL Streptococcus pneumoniae R6 dihydrolipoamide dehydrogenase NP_358642.1 1042274 R 171101 CDS NP_358643.2 161410746 934073 complement(1044023..1045066) 1 NC_003098.1 unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain; dihydrolipoamide acetyltransferase 1045066 acoC 934073 acoC Streptococcus pneumoniae R6 dihydrolipoamide acetyltransferase NP_358643.2 1044023 R 171101 CDS NP_358644.1 15903094 934165 complement(1045284..1046276) 1 NC_003098.1 acetoin dehydrogenase, E1 component subunit beta 1046276 acoB 934165 acoB Streptococcus pneumoniae R6 acetoin dehydrogenase, E1 component subunit beta NP_358644.1 1045284 R 171101 CDS NP_358645.1 15903095 934170 complement(1046292..1047260) 1 NC_003098.1 TPP-dependent acetoin dehydrogenase subunit alpha 1047260 acoA 934170 acoA Streptococcus pneumoniae R6 TPP-dependent acetoin dehydrogenase subunit alpha NP_358645.1 1046292 R 171101 CDS NP_358646.1 15903096 934077 complement(1047414..1048775) 1 NC_003098.1 MATE efflux family protein 1048775 934077 spr1052 Streptococcus pneumoniae R6 MATE efflux family protein NP_358646.1 1047414 R 171101 CDS NP_358647.1 15903097 934081 complement(1049060..1050328) 1 NC_003098.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1050328 pyrC 934081 pyrC Streptococcus pneumoniae R6 dihydroorotase NP_358647.1 1049060 R 171101 CDS NP_358648.1 15903098 933037 complement(1050341..1050805) 1 NC_003098.1 8-oxodGTP nucleoside triphosphatase 1050805 mutX 933037 mutX Streptococcus pneumoniae R6 8-oxodGTP nucleoside triphosphatase NP_358648.1 1050341 R 171101 CDS NP_358649.1 15903099 933680 complement(1050815..1051483) 1 NC_003098.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 1051483 ung 933680 ung Streptococcus pneumoniae R6 uracil-DNA glycosylase NP_358649.1 1050815 R 171101 CDS NP_358650.1 15903100 933471 complement(1051604..1052251) 1 NC_003098.1 hypothetical protein 1052251 933471 spr1056 Streptococcus pneumoniae R6 hypothetical protein NP_358650.1 1051604 R 171101 CDS NP_358651.1 15903101 932848 complement(1052265..1052978) 1 NC_003098.1 hypothetical protein 1052978 932848 spr1057 Streptococcus pneumoniae R6 hypothetical protein NP_358651.1 1052265 R 171101 CDS NP_358654.1 15903104 933226 complement(1054238..1056805) 1 NC_003098.1 histidine motif-containing protein 1056805 phpA 933226 phpA Streptococcus pneumoniae R6 histidine motif-containing protein NP_358654.1 1054238 R 171101 CDS NP_358655.1 15903105 933846 complement(1056930..1059416) 1 NC_003098.1 pneumococcal histidine triad protein A 1059416 phtA 933846 phtA Streptococcus pneumoniae R6 pneumococcal histidine triad protein A NP_358655.1 1056930 R 171101 CDS NP_358656.1 15903106 933754 complement(1059635..1061368) 1 NC_003098.1 phosphoenolpyruvate-protein phosphotransferase 1061368 ptsI 933754 ptsI Streptococcus pneumoniae R6 phosphoenolpyruvate-protein phosphotransferase NP_358656.1 1059635 R 171101 CDS NP_358657.1 15903107 932807 complement(1061374..1061637) 1 NC_003098.1 phosphocarrier protein HPr 1061637 ptsH 932807 ptsH Streptococcus pneumoniae R6 phosphocarrier protein HPr NP_358657.1 1061374 R 171101 CDS NP_358658.1 15903108 933182 1061970..1062206 1 NC_003098.1 glutaredoxin-like protein 1062206 nrdH 933182 nrdH Streptococcus pneumoniae R6 glutaredoxin-like protein NP_358658.1 1061970 D 171101 CDS NP_358659.1 15903109 933455 1062287..1064446 1 NC_003098.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1064446 nrdE 933455 nrdE Streptococcus pneumoniae R6 ribonucleotide-diphosphate reductase subunit alpha NP_358659.1 1062287 D 171101 CDS NP_358660.1 15903110 932802 1064634..1065596 1 NC_003098.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1065596 nrdF 932802 nrdF Streptococcus pneumoniae R6 ribonucleotide-diphosphate reductase subunit beta NP_358660.1 1064634 D 171101 CDS NP_358661.1 15903111 932931 1065778..1066539 1 NC_003098.1 lactose PTS system repressor 1066539 lacR 932931 lacR Streptococcus pneumoniae R6 lactose PTS system repressor NP_358661.1 1065778 D 171101 CDS NP_358662.1 15903112 932827 complement(1067037..1068443) 1 NC_003098.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 1068443 lacG 932827 lacG Streptococcus pneumoniae R6 6-phospho-beta-galactosidase NP_358662.1 1067037 R 171101 CDS NP_358663.1 15903113 933773 complement(1068652..1070343) 1 NC_003098.1 PTS system lactose-specific transporter subunit IIBC 1070343 lacE 933773 lacE Streptococcus pneumoniae R6 PTS system lactose-specific transporter subunit IIBC NP_358663.1 1068652 R 171101 CDS NP_358664.1 15903114 933794 complement(1070343..1070660) 1 NC_003098.1 PTS system lactose-specific transporter subunit IIA 1070660 lacF 933794 lacF Streptococcus pneumoniae R6 PTS system lactose-specific transporter subunit IIA NP_358664.1 1070343 R 171101 CDS NP_358665.1 15903115 932881 complement(1070696..1071532) 1 NC_003098.1 transcription antiterminator LacT 1071532 lacT 932881 lacT Streptococcus pneumoniae R6 transcription antiterminator LacT NP_358665.1 1070696 R 171101 CDS NP_358666.1 15903116 933800 complement(1071766..1072746) 1 NC_003098.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase 1072746 lacD 933800 lacD Streptococcus pneumoniae R6 tagatose 1,6-diphosphate aldolase NP_358666.1 1071766 R 171101 CDS NP_358667.1 15903117 933209 complement(1072748..1073677) 1 NC_003098.1 catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase 1073677 lacC 933209 lacC Streptococcus pneumoniae R6 tagatose-6-phosphate kinase NP_358667.1 1072748 R 171101 CDS NP_358668.1 15903118 933958 complement(1073688..1074203) 1 NC_003098.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB 1074203 lacB 933958 lacB Streptococcus pneumoniae R6 galactose-6-phosphate isomerase subunit LacB NP_358668.1 1073688 R 171101 CDS NP_358669.1 15903119 933185 complement(1074234..1074659) 1 NC_003098.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA 1074659 lacA 933185 lacA Streptococcus pneumoniae R6 galactose-6-phosphate isomerase subunit LacA NP_358669.1 1074234 R 171101 CDS NP_358671.1 15903121 933863 complement(1075330..1075728) 1 NC_003098.1 transposase 1075728 933863 spr1078 Streptococcus pneumoniae R6 transposase NP_358671.1 1075330 R 171101 CDS NP_358672.1 15903122 934030 complement(1075659..1076180) 1 NC_003098.1 hypothetical protein 1076180 934030 spr1079 Streptococcus pneumoniae R6 hypothetical protein NP_358672.1 1075659 R 171101 CDS NP_358673.1 15903123 933906 complement(1076140..1076442) 1 NC_003098.1 hypothetical protein 1076442 933906 spr1080 Streptococcus pneumoniae R6 hypothetical protein NP_358673.1 1076140 R 171101 CDS NP_358674.1 15903124 932942 complement(1076480..1076752) 1 NC_003098.1 hypothetical protein 1076752 932942 spr1081 Streptococcus pneumoniae R6 hypothetical protein NP_358674.1 1076480 R 171101 CDS YP_008719804.1 555247350 17374509 1077136..1077288 1 NC_003098.1 hypothetical protein 1077288 17374509 spr1079a Streptococcus pneumoniae R6 hypothetical protein YP_008719804.1 1077136 D 171101 CDS NP_358675.1 15903125 933087 complement(1077369..1079192) 1 NC_003098.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 1079192 lepA 933087 lepA Streptococcus pneumoniae R6 GTP-binding protein LepA NP_358675.1 1077369 R 171101 CDS NP_358676.1 15903126 933792 complement(1079271..1079999) 1 NC_003098.1 serine/threonine protein phosphatase 1079999 pphA 933792 pphA Streptococcus pneumoniae R6 serine/threonine protein phosphatase NP_358676.1 1079271 R 171101 CDS NP_358677.1 15903127 934047 complement(1080001..1081668) 1 NC_003098.1 DNA repair protein RecN 1081668 recN 934047 recN Streptococcus pneumoniae R6 DNA repair protein RecN NP_358677.1 1080001 R 171101 CDS NP_358678.1 15903128 933785 complement(1081675..1082106) 1 NC_003098.1 arginine metabolism transcriptional regulator 1082106 ahrC 933785 ahrC Streptococcus pneumoniae R6 arginine metabolism transcriptional regulator NP_358678.1 1081675 R 171101 CDS NP_358679.1 15903129 933503 complement(1082099..1082914) 1 NC_003098.1 Hemolysin-like protein; hypothetical protein 1082914 933503 spr1086 Streptococcus pneumoniae R6 hypothetical protein NP_358679.1 1082099 R 171101 CDS NP_358680.1 15903130 933371 complement(1082907..1083782) 1 NC_003098.1 geranyltranstransferase 1083782 ispA 933371 ispA Streptococcus pneumoniae R6 geranyltranstransferase NP_358680.1 1082907 R 171101 CDS NP_358681.1 15903131 933250 complement(1083779..1083991) 1 NC_003098.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 1083991 xseB 933250 xseB Streptococcus pneumoniae R6 exodeoxyribonuclease VII small subunit NP_358681.1 1083779 R 171101 CDS NP_358682.1 15903132 933134 complement(1083969..1085315) 1 NC_003098.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 1085315 xseA 933134 xseA Streptococcus pneumoniae R6 exodeoxyribonuclease VII large subunit NP_358682.1 1083969 R 171101 CDS NP_358683.1 15903133 933122 complement(1085437..1086075) 1 NC_003098.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1086075 udK 933122 udK Streptococcus pneumoniae R6 uridine kinase NP_358683.1 1085437 R 171101 CDS NP_358684.1 15903134 933148 complement(1086183..1086485) 1 NC_003098.1 hypothetical protein 1086485 933148 spr1091 Streptococcus pneumoniae R6 hypothetical protein NP_358684.1 1086183 R 171101 CDS NP_358685.1 15903135 933266 complement(1086726..1087604) 1 NC_003098.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1087604 truB 933266 truB Streptococcus pneumoniae R6 tRNA pseudouridine synthase B NP_358685.1 1086726 R 171101 CDS NP_358686.1 15903136 933791 complement(1087705..1090890) 1 NC_003098.1 hypothetical protein 1090890 933791 spr1093 Streptococcus pneumoniae R6 hypothetical protein NP_358686.1 1087705 R 171101 CDS NP_358687.1 15903137 933072 complement(1090902..1092176) 1 NC_003098.1 hypothetical protein 1092176 933072 spr1094 Streptococcus pneumoniae R6 hypothetical protein NP_358687.1 1090902 R 171101 CDS NP_358690.1 15903140 934032 complement(1093679..1094476) 1 NC_003098.1 formate/nitrate transporter 1094476 nirC 934032 nirC Streptococcus pneumoniae R6 formate/nitrate transporter NP_358690.1 1093679 R 171101 CDS NP_358691.1 15903141 933969 complement(1094720..1095463) 1 NC_003098.1 proposed to perform the peptide cleavage and the transpeptidation during the process of anchoring proteins to Gram-positive bacterial cell walls; sortase 1095463 srtA 933969 srtA Streptococcus pneumoniae R6 sortase NP_358691.1 1094720 R 171101 CDS NP_358692.1 15903142 933198 complement(1095463..1097931) 1 NC_003098.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 1097931 gyrA 933198 gyrA Streptococcus pneumoniae R6 DNA gyrase subunit A NP_358692.1 1095463 R 171101 CDS NP_358693.1 15903143 933245 1098125..1099111 1 NC_003098.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1099111 ldh 933245 ldh Streptococcus pneumoniae R6 L-lactate dehydrogenase NP_358693.1 1098125 D 171101 CDS NP_358694.1 15903144 933928 complement(1099497..1102751) 1 NC_003098.1 type II restriction endonuclease 1102751 spnII-interrupted-C 933928 spnII-interrupted-C Streptococcus pneumoniae R6 type II restriction endonuclease NP_358694.1 1099497 R 171101 CDS NP_358695.1 15903145 933783 complement(1102916..1104793) 1 NC_003098.1 type II restriction endonuclease 1104793 spnII-interrupted-N 933783 spnII-interrupted-N Streptococcus pneumoniae R6 type II restriction endonuclease NP_358695.1 1102916 R 171101 CDS NP_358696.1 15903146 933412 complement(1104862..1105125) 1 NC_003098.1 hypothetical protein 1105125 933412 spr1103 Streptococcus pneumoniae R6 hypothetical protein NP_358696.1 1104862 R 171101 CDS NP_358697.1 15903147 933121 complement(1105118..1105420) 1 NC_003098.1 hypothetical protein 1105420 933121 spr1104 Streptococcus pneumoniae R6 hypothetical protein NP_358697.1 1105118 R 171101 CDS NP_358698.1 15903148 933337 complement(1105451..1106260) 1 NC_003098.1 metal-dependent hydrolase 1106260 vicX 933337 vicX Streptococcus pneumoniae R6 metal-dependent hydrolase NP_358698.1 1105451 R 171101 CDS NP_358699.1 15903149 933765 complement(1106262..1107611) 1 NC_003098.1 sensory box sensor histidine kinase 1107611 hk02 933765 hk02 Streptococcus pneumoniae R6 sensory box sensor histidine kinase NP_358699.1 1106262 R 171101 CDS NP_358700.1 15903150 932912 complement(1107604..1108359) 1 NC_003098.1 DNA-binding response regulator 1108359 rr02 932912 rr02 Streptococcus pneumoniae R6 DNA-binding response regulator NP_358700.1 1107604 R 171101 CDS NP_358701.1 15903151 933900 complement(1108363..1109538) 1 NC_003098.1 A/G-specific adenine glycosylase 1109538 mutY 933900 mutY Streptococcus pneumoniae R6 A/G-specific adenine glycosylase NP_358701.1 1108363 R 171101 CDS NP_358702.1 15903152 933045 complement(1109867..1111537) 1 NC_003098.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 1111537 fhs 933045 fhs Streptococcus pneumoniae R6 formate--tetrahydrofolate ligase NP_358702.1 1109867 R 171101 CDS NP_358703.1 15903153 933205 1111752..1112456 1 NC_003098.1 phosphopantothenate--cysteine ligase 1112456 dfp-C-terminus 933205 dfp-C-terminus Streptococcus pneumoniae R6 phosphopantothenate--cysteine ligase NP_358703.1 1111752 D 171101 CDS NP_358704.1 15903154 933762 1112468..1113019 1 NC_003098.1 decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 1113019 dfp-N-terminus 933762 dfp-N-terminus Streptococcus pneumoniae R6 phosphopantothenoylcysteine decarboxylase NP_358704.1 1112468 D 171101 CDS NP_358705.1 15903155 932957 1113003..1113566 1 NC_003098.1 Probable membrane protein; hypothetical protein 1113566 932957 spr1112 Streptococcus pneumoniae R6 hypothetical protein NP_358705.1 1113003 D 171101 CDS NP_358706.1 15903156 933218 1113794..1114375 1 NC_003098.1 hypothetical protein 1114375 933218 spr1113 Streptococcus pneumoniae R6 hypothetical protein NP_358706.1 1113794 D 171101 CDS NP_358707.1 15903157 932954 1114387..1114902 1 NC_003098.1 Probable transcriptional regulator; hypothetical protein 1114902 932954 spr1114 Streptococcus pneumoniae R6 hypothetical protein NP_358707.1 1114387 D 171101 CDS NP_358708.1 15903158 932945 complement(1114899..1115366) 1 NC_003098.1 MutT-like protein; hypothetical protein 1115366 932945 spr1115 Streptococcus pneumoniae R6 hypothetical protein NP_358708.1 1114899 R 171101 CDS NP_358709.1 15903159 933162 complement(1115440..1115928) 1 NC_003098.1 Acetyltransferase (GNAT) family; hypothetical protein 1115928 933162 spr1116 Streptococcus pneumoniae R6 hypothetical protein NP_358709.1 1115440 R 171101 CDS NP_358710.1 15903160 933313 complement(1115894..1116457) 1 NC_003098.1 Probable acetyltransferase; hypothetical protein 1116457 933313 spr1117 Streptococcus pneumoniae R6 hypothetical protein NP_358710.1 1115894 R 171101 CDS NP_358711.1 15903161 933244 complement(1116467..1118455) 1 NC_003098.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1118455 uvrB 933244 uvrB Streptococcus pneumoniae R6 excinuclease ABC subunit B NP_358711.1 1116467 R 171101 CDS NP_358712.1 15903162 933140 complement(1118532..1119485) 1 NC_003098.1 transmembrane protein; hypothetical protein 1119485 933140 spr1119 Streptococcus pneumoniae R6 hypothetical protein NP_358712.1 1118532 R 171101 CDS NP_358713.1 15903163 934028 1119658..1121823 1 NC_003098.1 amino acid ABC transporter substrate-binding protein 1121823 glnP 934028 glnP Streptococcus pneumoniae R6 amino acid ABC transporter substrate-binding protein NP_358713.1 1119658 D 171101 CDS NP_358714.1 15903164 933796 1121823..1122563 1 NC_003098.1 amino acid ABC transporter ATP-binding protein 1122563 glnQ 933796 glnQ Streptococcus pneumoniae R6 amino acid ABC transporter ATP-binding protein NP_358714.1 1121823 D 171101 CDS NP_358715.1 15903165 933288 1122712..1124199 1 NC_003098.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1124199 zwf 933288 zwf Streptococcus pneumoniae R6 glucose-6-phosphate 1-dehydrogenase NP_358715.1 1122712 D 171101 CDS NP_358716.1 15903166 933257 complement(1124245..1125522) 1 NC_003098.1 signal recognition particle-docking protein FtsY 1125522 ftsY 933257 ftsY Streptococcus pneumoniae R6 signal recognition particle-docking protein FtsY NP_358716.1 1124245 R 171101 CDS NP_358717.1 15903167 933814 complement(1125526..1126344) 1 NC_003098.1 Cof family protein 1126344 933814 spr1124 Streptococcus pneumoniae R6 Cof family protein NP_358717.1 1125526 R 171101 CDS NP_358718.1 15903168 933655 complement(1126344..1127138) 1 NC_003098.1 Cof family protein 1127138 933655 spr1125 Streptococcus pneumoniae R6 Cof family protein NP_358718.1 1126344 R 171101 CDS NP_358719.1 15903169 933157 complement(1127135..1130674) 1 NC_003098.1 chromosome condensation and segregation SMC protein 1130674 smc 933157 smc Streptococcus pneumoniae R6 chromosome condensation and segregation SMC protein NP_358719.1 1127135 R 171101 CDS NP_358720.1 15903170 932926 complement(1130665..1131363) 1 NC_003098.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 1131363 rnc 932926 rnc Streptococcus pneumoniae R6 ribonuclease III NP_358720.1 1130665 R 171101 CDS NP_358721.1 15903171 933293 complement(1131681..1132667) 1 NC_003098.1 guanosine 5'-monophosphate oxidoreductase 1132667 guaC 933293 guaC Streptococcus pneumoniae R6 guanosine 5'-monophosphate oxidoreductase NP_358721.1 1131681 R 171101 CDS NP_358722.1 15903172 932798 complement(1132842..1134185) 1 NC_003098.1 hypothetical protein 1134185 932798 spr1129 Streptococcus pneumoniae R6 hypothetical protein NP_358722.1 1132842 R 171101 CDS NP_358723.1 15903173 933897 complement(1134145..1136079) 1 NC_003098.1 Probable endonuclease; endonuclease 1136079 933897 spr1130 Streptococcus pneumoniae R6 endonuclease NP_358723.1 1134145 R 171101 CDS NP_358724.1 15903174 933326 complement(1136240..1136410) 1 NC_003098.1 hypothetical protein 1136410 933326 spr1131 Streptococcus pneumoniae R6 hypothetical protein NP_358724.1 1136240 R 171101 CDS NP_358725.1 15903175 932830 complement(1136391..1136564) 1 NC_003098.1 hypothetical protein 1136564 932830 spr1132 Streptococcus pneumoniae R6 hypothetical protein NP_358725.1 1136391 R 171101 CDS NP_358727.1 15903177 932826 complement(1137389..1137658) 1 NC_003098.1 hypothetical protein 1137658 932826 spr1134 Streptococcus pneumoniae R6 hypothetical protein NP_358727.1 1137389 R 171101 CDS NP_358728.1 15903178 933207 complement(1137655..1138692) 1 NC_003098.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 1138692 leuB 933207 leuB Streptococcus pneumoniae R6 3-isopropylmalate dehydrogenase NP_358728.1 1137655 R 171101 CDS NP_358731.1 15903181 933271 complement(1139817..1140473) 1 NC_003098.1 hypothetical protein 1140473 933271 spr1138 Streptococcus pneumoniae R6 hypothetical protein NP_358731.1 1139817 R 171101 CDS NP_358732.1 15903182 932966 complement(1140517..1141149) 1 NC_003098.1 copper homeostasis protein CutC 1141149 cutC 932966 cutC Streptococcus pneumoniae R6 copper homeostasis protein CutC NP_358732.1 1140517 R 171101 CDS NP_358733.1 15903183 933904 complement(1141242..1141601) 1 NC_003098.1 hypothetical protein 1141601 933904 spr1140 Streptococcus pneumoniae R6 hypothetical protein NP_358733.1 1141242 R 171101 CDS NP_358734.1 15903184 933880 complement(1141707..1143812) 1 NC_003098.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1143812 topA 933880 topA Streptococcus pneumoniae R6 DNA topoisomerase I NP_358734.1 1141707 R 171101 CDS NP_358735.1 15903185 933253 complement(1143961..1145004) 1 NC_003098.1 hypothetical protein 1145004 933253 spr1142 Streptococcus pneumoniae R6 hypothetical protein NP_358735.1 1143961 R 171101 CDS NP_358737.1 15903187 933320 complement(1145894..1146754) 1 NC_003098.1 Also known as Competence induced loci B, CilB; DNA processing protein DprA 1146754 smf 933320 smf Streptococcus pneumoniae R6 DNA processing protein DprA NP_358737.1 1145894 R 171101 CDS NP_358738.1 15903188 933831 complement(1146838..1147527) 1 NC_003098.1 hypothetical protein 1147527 licC 933831 licC Streptococcus pneumoniae R6 hypothetical protein NP_358738.1 1146838 R 171101 CDS NP_358739.1 15903189 933852 complement(1147539..1148429) 1 NC_003098.1 hypothetical protein 1148429 licB 933852 licB Streptococcus pneumoniae R6 hypothetical protein NP_358739.1 1147539 R 171101 CDS NP_358740.1 15903190 933258 complement(1148407..1149276) 1 NC_003098.1 choline kinase 1149276 pck 933258 pck Streptococcus pneumoniae R6 choline kinase NP_358740.1 1148407 R 171101 CDS NP_358741.1 15903191 932935 complement(1149293..1150333) 1 NC_003098.1 Probable oxidoreductase; zinc-containing alcohol dehydrogenase 1150333 932935 spr1148 Streptococcus pneumoniae R6 zinc-containing alcohol dehydrogenase NP_358741.1 1149293 R 171101 CDS NP_358742.1 15903192 933316 complement(1150320..1151027) 1 NC_003098.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1151027 ispD 933316 ispD Streptococcus pneumoniae R6 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NP_358742.1 1150320 R 171101 CDS NP_358743.1 15903193 933321 1151363..1152850 1 NC_003098.1 Probable oligosaccharide repeat unit transporter; polysaccharide biosynthesis protein 1152850 933321 spr1150 Streptococcus pneumoniae R6 polysaccharide biosynthesis protein NP_358743.1 1151363 D 171101 CDS NP_358744.1 15903194 933252 1152860..1153663 1 NC_003098.1 required for phosphorylcholine incorporation in teichoic and lipoteichoic acids 1153663 licD1 933252 licD1 Streptococcus pneumoniae R6 required for phosphorylcholine incorporation in teichoic and lipoteichoic acids NP_358744.1 1152860 D 171101 CDS NP_358745.1 15903195 933341 1153665..1154474 1 NC_003098.1 Required for phosphorylcholine incorporation in teichoic and lipoteichoic acids; licD protein 1154474 licD2 933341 licD2 Streptococcus pneumoniae R6 licD protein NP_358745.1 1153665 D 171101 CDS NP_358746.1 15903196 933355 complement(1154749..1157925) 1 NC_003098.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1157925 carB 933355 carB Streptococcus pneumoniae R6 carbamoyl phosphate synthase large subunit NP_358746.1 1154749 R 171101 CDS NP_358747.1 15903197 933238 complement(1158238..1159317) 1 NC_003098.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1159317 carA 933238 carA Streptococcus pneumoniae R6 carbamoyl phosphate synthase small subunit NP_358747.1 1158238 R 171101 CDS NP_358748.1 15903198 933189 complement(1159367..1160290) 1 NC_003098.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 1160290 pyrB 933189 pyrB Streptococcus pneumoniae R6 aspartate carbamoyltransferase NP_358748.1 1159367 R 171101 CDS NP_358749.1 15903199 933441 complement(1160309..1160830) 1 NC_003098.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase 1160830 pyrR 933441 pyrR Streptococcus pneumoniae R6 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase NP_358749.1 1160309 R 171101 CDS NP_358750.1 15903200 933279 complement(1161041..1161670) 1 NC_003098.1 endonuclease III 1161670 nth 933279 nth Streptococcus pneumoniae R6 endonuclease III NP_358750.1 1161041 R 171101 CDS NP_358751.1 15903201 933191 complement(1161670..1162212) 1 NC_003098.1 hypothetical protein 1162212 933191 spr1158 Streptococcus pneumoniae R6 hypothetical protein NP_358751.1 1161670 R 171101 CDS NP_358754.1 15903204 933416 1162971..1164497 1 NC_003098.1 ABC transporter ATP-binding protein 1164497 ABC-NBD 933416 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358754.1 1162971 D 171101 CDS NP_358755.1 15903205 932914 complement(1164646..1165554) 1 NC_003098.1 metalloprotease; heat shock protein HtpX 1165554 htpX 932914 htpX Streptococcus pneumoniae R6 heat shock protein HtpX NP_358755.1 1164646 R 171101 CDS NP_358756.1 15903206 934068 complement(1165547..1166107) 1 NC_003098.1 cytoplasmic membrane protein 1166107 lemA 934068 lemA Streptococcus pneumoniae R6 cytoplasmic membrane protein NP_358756.1 1165547 R 171101 CDS NP_358757.1 15903207 933340 1166177..1166914 1 NC_003098.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1166914 gidB 933340 gidB Streptococcus pneumoniae R6 16S rRNA methyltransferase GidB NP_358757.1 1166177 D 171101 CDS NP_358758.1 15903208 933249 1167230..1168549 1 NC_003098.1 uracil permease 1168549 pyrP 933249 pyrP Streptococcus pneumoniae R6 uracil permease NP_358758.1 1167230 D 171101 CDS NP_358759.1 15903209 933912 complement(1168744..1170315) 1 NC_003098.1 signal recognition particle protein 1170315 ffh 933912 ffh Streptococcus pneumoniae R6 signal recognition particle protein NP_358759.1 1168744 R 171101 CDS NP_358760.1 15903210 932921 complement(1170327..1170659) 1 NC_003098.1 DNA-binding protein 1170659 932921 spr1167 Streptococcus pneumoniae R6 DNA-binding protein NP_358760.1 1170327 R 171101 CDS NP_358761.1 15903211 933175 complement(1170750..1171127) 1 NC_003098.1 hypothetical protein 1171127 933175 spr1168 Streptococcus pneumoniae R6 hypothetical protein NP_358761.1 1170750 R 171101 CDS NP_358762.1 15903212 933220 1171103..1172503 1 NC_003098.1 hypothetical protein 1172503 933220 spr1169 Streptococcus pneumoniae R6 hypothetical protein NP_358762.1 1171103 D 171101 CDS NP_358763.1 15903213 933184 1172516..1173322 1 NC_003098.1 Cof family protein 1173322 933184 spr1170 Streptococcus pneumoniae R6 Cof family protein NP_358763.1 1172516 D 171101 CDS NP_358764.1 15903214 932995 complement(1173490..1173837) 1 NC_003098.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1173837 rplS 932995 rplS Streptococcus pneumoniae R6 50S ribosomal protein L19 NP_358764.1 1173490 R 171101 CDS NP_358765.1 15903215 933959 complement(1173956..1174285) 1 NC_003098.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1174285 crcB 933959 crcB Streptococcus pneumoniae R6 camphor resistance protein CrcB NP_358765.1 1173956 R 171101 CDS NP_358766.1 15903216 934163 complement(1174279..1174653) 1 NC_003098.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1174653 crcB 934163 crcB Streptococcus pneumoniae R6 camphor resistance protein CrcB NP_358766.1 1174279 R 171101 CDS NP_358767.1 15903217 933949 complement(1174650..1174916) 1 NC_003098.1 hypothetical protein 1174916 933949 spr1174 Streptococcus pneumoniae R6 hypothetical protein NP_358767.1 1174650 R 171101 CDS NP_358768.1 15903218 933952 complement(1175032..1175475) 1 NC_003098.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 1175475 flaV 933952 flaV Streptococcus pneumoniae R6 flavodoxin NP_358768.1 1175032 R 171101 CDS NP_358769.1 15903219 933806 1175567..1176514 1 NC_003098.1 DHH subfamily 1 protein 1176514 933806 spr1176 Streptococcus pneumoniae R6 DHH subfamily 1 protein NP_358769.1 1175567 D 171101 CDS NP_358770.1 15903220 933825 1176610..1176852 1 NC_003098.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1176852 rpmE2 933825 rpmE2 Streptococcus pneumoniae R6 50S ribosomal protein L31 NP_358770.1 1176610 D 171101 CDS NP_358771.1 15903221 933834 complement(1176909..1177487) 1 NC_003098.1 hypothetical protein 1177487 933834 spr1178 Streptococcus pneumoniae R6 hypothetical protein NP_358771.1 1176909 R 171101 CDS NP_358772.1 15903222 933059 complement(1177462..1178466) 1 NC_003098.1 hypothetical protein 1178466 933059 spr1179 Streptococcus pneumoniae R6 hypothetical protein NP_358772.1 1177462 R 171101 CDS NP_358774.1 15903224 934142 1179472..1180818 1 NC_003098.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1180818 gdhA 934142 gdhA Streptococcus pneumoniae R6 glutamate dehydrogenase NP_358774.1 1179472 D 171101 CDS NP_358775.1 15903225 934144 complement(1181314..1181484) 1 NC_003098.1 hypothetical protein 1181484 934144 spr1182 Streptococcus pneumoniae R6 hypothetical protein NP_358775.1 1181314 R 171101 CDS NP_358776.1 15903226 934145 complement(1181497..1182138) 1 NC_003098.1 ABC transporter ATP-binding protein 1182138 934145 spr1183 Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358776.1 1181497 R 171101 CDS NP_358778.1 15903228 934148 complement(1183138..1183341) 1 NC_003098.1 hypothetical protein 1183341 934148 spr1185 Streptococcus pneumoniae R6 hypothetical protein NP_358778.1 1183138 R 171101 CDS NP_358781.1 15903231 934151 complement(1184308..1184715) 1 NC_003098.1 cytidine deaminase 1184715 cdd 934151 cdd Streptococcus pneumoniae R6 cytidine deaminase NP_358781.1 1184308 R 171101 CDS NP_358782.1 15903232 934152 complement(1185003..1185491) 1 NC_003098.1 hypothetical protein 1185491 934152 spr1189 Streptococcus pneumoniae R6 hypothetical protein NP_358782.1 1185003 R 171101 CDS NP_358783.1 15903233 934153 complement(1185496..1186914) 1 NC_003098.1 hypothetical protein 1186914 934153 spr1190 Streptococcus pneumoniae R6 hypothetical protein NP_358783.1 1185496 R 171101 CDS NP_358784.1 15903234 934155 complement(1186915..1188897) 1 NC_003098.1 peptide ABC transporter ATP-binding protein 1188897 appD 934155 appD Streptococcus pneumoniae R6 peptide ABC transporter ATP-binding protein NP_358784.1 1186915 R 171101 CDS NP_358785.1 15903235 934156 complement(1188910..1189761) 1 NC_003098.1 peptide ABC transporter permease 1189761 appC 934156 appC Streptococcus pneumoniae R6 peptide ABC transporter permease NP_358785.1 1188910 R 171101 CDS NP_358786.1 15903236 934157 complement(1189778..1190773) 1 NC_003098.1 peptide ABC transporter permease 1190773 appB 934157 appB Streptococcus pneumoniae R6 peptide ABC transporter permease NP_358786.1 1189778 R 171101 CDS NP_358787.1 15903237 934158 complement(1190838..1192466) 1 NC_003098.1 oligopeptide ABC transporter substrate-binding protein 1192466 appA 934158 appA Streptococcus pneumoniae R6 oligopeptide ABC transporter substrate-binding protein NP_358787.1 1190838 R 171101 CDS NP_358788.1 15903238 932793 complement(1192548..1193471) 1 NC_003098.1 hypothetical protein 1193471 932793 spr1195 Streptococcus pneumoniae R6 hypothetical protein NP_358788.1 1192548 R 171101 CDS NP_358789.1 15903239 934409 complement(1193495..1194193) 1 NC_003098.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 1194193 nanE 934409 nanE Streptococcus pneumoniae R6 N-acetylmannosamine-6-phosphate 2-epimerase NP_358789.1 1193495 R 171101 CDS NP_358792.1 15903242 934412 complement(1195086..1195307) 1 NC_003098.1 hypothetical protein 1195307 934412 spr1199 Streptococcus pneumoniae R6 hypothetical protein NP_358792.1 1195086 R 171101 CDS NP_358794.1 15903244 934413 complement(1196371..1197690) 1 NC_003098.1 hypothetical protein 1197690 934413 spr1201 Streptococcus pneumoniae R6 hypothetical protein NP_358794.1 1196371 R 171101 CDS NP_358795.1 15903245 934415 complement(1197693..1198451) 1 NC_003098.1 ABC transporter ATP-binding protein 1198451 ABC-NDB 934415 ABC-NDB Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358795.1 1197693 R 171101 CDS NP_358796.1 15903246 934427 complement(1198448..1200055) 1 NC_003098.1 drug efflux ABC transporter ATP-binding/permease 1200055 ABC-NP 934427 ABC-NP Streptococcus pneumoniae R6 drug efflux ABC transporter ATP-binding/permease NP_358796.1 1198448 R 171101 CDS NP_358797.1 15903247 934419 complement(1200052..1201992) 1 NC_003098.1 prolyl oligopeptidase 1201992 ptrB 934419 ptrB Streptococcus pneumoniae R6 prolyl oligopeptidase NP_358797.1 1200052 R 171101 CDS NP_358798.1 15903248 934416 complement(1202025..1204661) 1 NC_003098.1 hypothetical protein 1204661 934416 spr1205 Streptococcus pneumoniae R6 hypothetical protein NP_358798.1 1202025 R 171101 CDS NP_358799.1 15903249 934423 complement(1205152..1205739) 1 NC_003098.1 hypothetical protein 1205739 934423 spr1206 Streptococcus pneumoniae R6 hypothetical protein NP_358799.1 1205152 R 171101 CDS NP_358800.1 15903250 934417 complement(1205988..1206368) 1 NC_003098.1 hypothetical protein 1206368 934417 spr1207 Streptococcus pneumoniae R6 hypothetical protein NP_358800.1 1205988 R 171101 CDS NP_358801.1 15903251 934418 complement(1206423..1206701) 1 NC_003098.1 hypothetical protein 1206701 934418 spr1208 Streptococcus pneumoniae R6 hypothetical protein NP_358801.1 1206423 R 171101 CDS NP_358802.1 15903252 934425 complement(1206709..1206963) 1 NC_003098.1 hypothetical protein 1206963 934425 spr1209 Streptococcus pneumoniae R6 hypothetical protein NP_358802.1 1206709 R 171101 CDS NP_358803.1 15903253 934420 complement(1206960..1207172) 1 NC_003098.1 hypothetical protein 1207172 934420 spr1210 Streptococcus pneumoniae R6 hypothetical protein NP_358803.1 1206960 R 171101 CDS NP_358804.2 161410745 934421 complement(1207321..1207689) 1 NC_003098.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1207689 rplL 934421 rplL Streptococcus pneumoniae R6 50S ribosomal protein L7/L12 NP_358804.2 1207321 R 171101 CDS NP_358805.1 15903255 934429 complement(1207765..1208265) 1 NC_003098.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1208265 rplJ 934429 rplJ Streptococcus pneumoniae R6 50S ribosomal protein L10 NP_358805.1 1207765 R 171101 CDS NP_358807.2 161410744 934426 complement(1208515..1209831) 1 NC_003098.1 chlorohydrolase 1209831 trzA 934426 trzA Streptococcus pneumoniae R6 chlorohydrolase NP_358807.2 1208515 R 171101 CDS NP_358808.1 15903258 934428 complement(1210076..1211866) 1 NC_003098.1 ABC transporter ATP-binding protein/permease 1211866 ABC-N/P 934428 ABC-N/P Streptococcus pneumoniae R6 ABC transporter ATP-binding protein/permease NP_358808.1 1210076 R 171101 CDS NP_358809.1 15903259 934430 complement(1211829..1213553) 1 NC_003098.1 ABC transporter ATP-binding protein/permease 1213553 ABC-N/P 934430 ABC-N/P Streptococcus pneumoniae R6 ABC transporter ATP-binding protein/permease NP_358809.1 1211829 R 171101 CDS NP_358810.1 15903260 934434 complement(1213611..1214549) 1 NC_003098.1 this fusion consists of methionine sulfoxide A reductase at the N-terminus and B at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion; bifunctional methionine sulfoxide reductase A/B protein 1214549 msrA 934434 msrA Streptococcus pneumoniae R6 bifunctional methionine sulfoxide reductase A/B protein NP_358810.1 1213611 R 171101 CDS NP_358811.1 15903261 934431 complement(1214845..1215714) 1 NC_003098.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1215714 thrB 934431 thrB Streptococcus pneumoniae R6 homoserine kinase NP_358811.1 1214845 R 171101 CDS NP_358812.2 229000971 934437 complement(1215716..1217002) 1 NC_003098.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1217002 hom 934437 hom Streptococcus pneumoniae R6 homoserine dehydrogenase NP_358812.2 1215716 R 171101 CDS NP_358813.1 15903263 934432 complement(1217153..1217890) 1 NC_003098.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein 1217890 mecA 934432 mecA Streptococcus pneumoniae R6 adaptor protein NP_358813.1 1217153 R 171101 CDS NP_358814.1 15903264 934433 complement(1218032..1219066) 1 NC_003098.1 hypothetical protein 1219066 934433 spr1221 Streptococcus pneumoniae R6 hypothetical protein NP_358814.1 1218032 R 171101 CDS NP_358815.1 15903265 934447 complement(1219095..1220528) 1 NC_003098.1 hypothetical protein 1220528 934447 spr1222 Streptococcus pneumoniae R6 hypothetical protein NP_358815.1 1219095 R 171101 CDS NP_358816.1 15903266 934436 complement(1220544..1221530) 1 NC_003098.1 galactosyl transferase 1221530 cps23FU 934436 cps23FU Streptococcus pneumoniae R6 galactosyl transferase NP_358816.1 1220544 R 171101 CDS NP_358817.1 15903267 934444 complement(1221532..1222689) 1 NC_003098.1 Similar to capsular polysaccharide biosynthsis protein; hypothetical protein 1222689 934444 spr1224 Streptococcus pneumoniae R6 hypothetical protein NP_358817.1 1221532 R 171101 CDS NP_358818.1 15903268 934441 complement(1222625..1223470) 1 NC_003098.1 licD protein 1223470 licD1 934441 licD1 Streptococcus pneumoniae R6 licD protein NP_358818.1 1222625 R 171101 CDS NP_358819.1 15903269 934438 complement(1223749..1225023) 1 NC_003098.1 transcriptional regulator; hypothetical protein 1225023 934438 spr1226 Streptococcus pneumoniae R6 hypothetical protein NP_358819.1 1223749 R 171101 CDS NP_358820.1 15903270 934451 complement(1225020..1225868) 1 NC_003098.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 1225868 pheA 934451 pheA Streptococcus pneumoniae R6 prephenate dehydratase NP_358820.1 1225020 R 171101 CDS NP_358821.1 15903271 934443 complement(1225865..1226341) 1 NC_003098.1 shikimate kinase 1226341 aroK 934443 aroK Streptococcus pneumoniae R6 shikimate kinase NP_358821.1 1225865 R 171101 CDS NP_358822.1 15903272 934439 complement(1226334..1227629) 1 NC_003098.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1227629 aroA 934439 aroA Streptococcus pneumoniae R6 3-phosphoshikimate 1-carboxyvinyltransferase NP_358822.1 1226334 R 171101 CDS NP_358823.1 15903273 934450 complement(1227709..1228047) 1 NC_003098.1 hypothetical protein 1228047 934450 spr1230 Streptococcus pneumoniae R6 hypothetical protein NP_358823.1 1227709 R 171101 CDS NP_358824.1 15903274 934440 complement(1228058..1229161) 1 NC_003098.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 1229161 tyrA 934440 tyrA Streptococcus pneumoniae R6 prephenate dehydrogenase NP_358824.1 1228058 R 171101 CDS NP_358825.1 15903275 934448 complement(1229171..1230337) 1 NC_003098.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1230337 aroC 934448 aroC Streptococcus pneumoniae R6 chorismate synthase NP_358825.1 1229171 R 171101 CDS NP_358826.1 15903276 934442 complement(1230347..1231414) 1 NC_003098.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1231414 aroB 934442 aroB Streptococcus pneumoniae R6 3-dehydroquinate synthase NP_358826.1 1230347 R 171101 CDS NP_358827.1 15903277 934445 complement(1231433..1232287) 1 NC_003098.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1232287 aroE 934445 aroE Streptococcus pneumoniae R6 shikimate 5-dehydrogenase NP_358827.1 1231433 R 171101 CDS NP_358828.1 15903278 934452 complement(1232277..1232954) 1 NC_003098.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1232954 aroD 934452 aroD Streptococcus pneumoniae R6 3-dehydroquinate dehydratase NP_358828.1 1232277 R 171101 CDS NP_358829.1 15903279 934468 complement(1232951..1234123) 1 NC_003098.1 hypothetical protein 1234123 934468 spr1236 Streptococcus pneumoniae R6 hypothetical protein NP_358829.1 1232951 R 171101 CDS NP_358830.1 15903280 934446 complement(1234801..1236462) 1 NC_003098.1 hypothetical protein 1236462 934446 spr1237 Streptococcus pneumoniae R6 hypothetical protein NP_358830.1 1234801 R 171101 CDS NP_358831.1 15903281 934455 complement(1236416..1237222) 1 NC_003098.1 ABC transporter ATP-binding protein 1237222 ABC-NBD 934455 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358831.1 1236416 R 171101 CDS NP_358832.1 15903282 934449 1237343..1238797 1 NC_003098.1 converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 1238797 amy 934449 amy Streptococcus pneumoniae R6 cytoplasmic alpha-amylase NP_358832.1 1237343 D 171101 CDS NP_358833.1 15903283 934453 complement(1238887..1241505) 1 NC_003098.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1241505 alaS 934453 alaS Streptococcus pneumoniae R6 alanyl-tRNA synthetase NP_358833.1 1238887 R 171101 CDS NP_358834.1 15903284 934456 complement(1241527..1242024) 1 NC_003098.1 hypothetical protein 1242024 934456 spr1241 Streptococcus pneumoniae R6 hypothetical protein NP_358834.1 1241527 R 171101 CDS NP_358835.1 15903285 934454 complement(1242287..1242526) 1 NC_003098.1 hypothetical protein 1242526 934454 spr1242 Streptococcus pneumoniae R6 hypothetical protein NP_358835.1 1242287 R 171101 CDS NP_358836.1 15903286 934459 complement(1242787..1243857) 1 NC_003098.1 spermidine/putrescine ABC transporter substrate-binding protein 1243857 potD 934459 potD Streptococcus pneumoniae R6 spermidine/putrescine ABC transporter substrate-binding protein NP_358836.1 1242787 R 171101 CDS NP_358837.1 15903287 934457 complement(1243854..1244627) 1 NC_003098.1 spermidine/putrescine ABC transporter permease 1244627 potC 934457 potC Streptococcus pneumoniae R6 spermidine/putrescine ABC transporter permease NP_358837.1 1243854 R 171101 CDS NP_358838.1 15903288 934458 complement(1244624..1245451) 1 NC_003098.1 spermidine/putrescine ABC transporter permease 1245451 potB 934458 potB Streptococcus pneumoniae R6 spermidine/putrescine ABC transporter permease NP_358838.1 1244624 R 171101 CDS NP_358839.1 15903289 934460 complement(1245411..1246568) 1 NC_003098.1 spermidine/putrescine ABC transporter ATP-binding protein 1246568 potA 934460 potA Streptococcus pneumoniae R6 spermidine/putrescine ABC transporter ATP-binding protein NP_358839.1 1245411 R 171101 CDS NP_358840.1 15903290 934461 complement(1246627..1247577) 1 NC_003098.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 1247577 murB 934461 murB Streptococcus pneumoniae R6 UDP-N-acetylenolpyruvoylglucosamine reductase NP_358840.1 1246627 R 171101 CDS NP_358841.1 15903291 934464 complement(1247689..1248441) 1 NC_003098.1 hypothetical protein 1248441 934464 spr1248 Streptococcus pneumoniae R6 hypothetical protein NP_358841.1 1247689 R 171101 CDS NP_358842.1 15903292 934465 complement(1248451..1249182) 1 NC_003098.1 alpha-acetolactate decarboxylase 1249182 aldB 934465 aldB Streptococcus pneumoniae R6 alpha-acetolactate decarboxylase NP_358842.1 1248451 R 171101 CDS NP_358843.1 15903293 934462 1249324..1250595 1 NC_003098.1 hypothetical protein 1250595 934462 spr1250 Streptococcus pneumoniae R6 hypothetical protein NP_358843.1 1249324 D 171101 CDS NP_358844.1 15903294 934463 complement(1250615..1251430) 1 NC_003098.1 amino acid ABC transporter amino acid-binding protein 1251430 glnH 934463 glnH Streptococcus pneumoniae R6 amino acid ABC transporter amino acid-binding protein NP_358844.1 1250615 R 171101 CDS NP_358845.1 15903295 934483 complement(1251587..1252240) 1 NC_003098.1 phosphate transporter PhoU 1252240 phoU 934483 phoU Streptococcus pneumoniae R6 phosphate transporter PhoU NP_358845.1 1251587 R 171101 CDS NP_358846.1 15903296 934467 complement(1252252..1253010) 1 NC_003098.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1253010 pstB 934467 pstB Streptococcus pneumoniae R6 phosphate transporter ATP-binding protein NP_358846.1 1252252 R 171101 CDS NP_358847.1 15903297 934466 complement(1253023..1253826) 1 NC_003098.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1253826 pstB 934466 pstB Streptococcus pneumoniae R6 phosphate transporter ATP-binding protein NP_358847.1 1253023 R 171101 CDS NP_358848.1 15903298 934472 complement(1253837..1254721) 1 NC_003098.1 phosphate ABC transporter permease 1254721 pstA 934472 pstA Streptococcus pneumoniae R6 phosphate ABC transporter permease NP_358848.1 1253837 R 171101 CDS NP_358849.1 15903299 934470 complement(1254711..1255628) 1 NC_003098.1 phosphate ABC transporter permease 1255628 pstC 934470 pstC Streptococcus pneumoniae R6 phosphate ABC transporter permease NP_358849.1 1254711 R 171101 CDS NP_358850.1 15903300 934469 complement(1255628..1256506) 1 NC_003098.1 phosphate ABC transporter substrate+B766-binding protein 1256506 pstS 934469 pstS Streptococcus pneumoniae R6 phosphate ABC transporter substrate+B766-binding protein NP_358850.1 1255628 R 171101 CDS NP_358853.1 15903303 934476 complement(1258385..1259233) 1 NC_003098.1 Similar to E. coli extragenic suppressor protein SuhB; inositol monophosphatase 1259233 934476 spr1260 Streptococcus pneumoniae R6 inositol monophosphatase NP_358853.1 1258385 R 171101 CDS NP_358854.1 15903304 934481 complement(1259148..1259426) 1 NC_003098.1 hypothetical protein 1259426 934481 spr1261 Streptococcus pneumoniae R6 hypothetical protein NP_358854.1 1259148 R 171101 CDS NP_358855.1 15903305 934475 complement(1259426..1259827) 1 NC_003098.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 1259827 spxA 934475 spxA Streptococcus pneumoniae R6 transcriptional regulator Spx NP_358855.1 1259426 R 171101 CDS NP_358856.1 15903306 934478 complement(1260037..1260687) 1 NC_003098.1 hypothetical protein 1260687 934478 spr1263 Streptococcus pneumoniae R6 hypothetical protein NP_358856.1 1260037 R 171101 CDS NP_358857.1 15903307 934502 complement(1260644..1261417) 1 NC_003098.1 N-acetyl-glucosamine matabolism 1261417 nagD 934502 nagD Streptococcus pneumoniae R6 N-acetyl-glucosamine matabolism NP_358857.1 1260644 R 171101 CDS NP_358858.1 15903308 934474 complement(1261428..1262165) 1 NC_003098.1 Acyl-ACP thioesterase; acyl-ACP thioesterase 1262165 934474 spr1265 Streptococcus pneumoniae R6 acyl-ACP thioesterase NP_358858.1 1261428 R 171101 CDS NP_358859.1 15903309 934487 complement(1262170..1263300) 1 NC_003098.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 1263300 hemN 934487 hemN Streptococcus pneumoniae R6 coproporphyrinogen III oxidase NP_358859.1 1262170 R 171101 CDS NP_358860.1 15903310 934477 complement(1263384..1263773) 1 NC_003098.1 hypothetical protein 1263773 934477 spr1267 Streptococcus pneumoniae R6 hypothetical protein NP_358860.1 1263384 R 171101 CDS NP_358861.1 15903311 934479 complement(1263789..1264172) 1 NC_003098.1 hypothetical protein 1264172 934479 spr1268 Streptococcus pneumoniae R6 hypothetical protein NP_358861.1 1263789 R 171101 CDS NP_358862.1 15903312 934486 complement(1264173..1264973) 1 NC_003098.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1264973 lgt 934486 lgt Streptococcus pneumoniae R6 prolipoprotein diacylglyceryl transferase NP_358862.1 1264173 R 171101 CDS NP_358863.1 15903313 934482 complement(1264954..1265904) 1 NC_003098.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 1265904 hprK 934482 hprK Streptococcus pneumoniae R6 HPr kinase/phosphorylase NP_358863.1 1264954 R 171101 CDS NP_358864.1 15903314 934480 complement(1266019..1266219) 1 NC_003098.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1266219 rpsU 934480 rpsU Streptococcus pneumoniae R6 30S ribosomal protein S21 NP_358864.1 1266019 R 171101 CDS NP_358865.1 15903315 934489 complement(1266335..1267057) 1 NC_003098.1 glucosamine-6-phosphate isomerase 1267057 nagB 934489 nagB Streptococcus pneumoniae R6 glucosamine-6-phosphate isomerase NP_358865.1 1266335 R 171101 CDS NP_358866.1 15903316 934484 1267181..1268221 1 NC_003098.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 1268221 queA 934484 queA Streptococcus pneumoniae R6 S-adenosylmethionine:tRNA ribosyltransferase-isomerase NP_358866.1 1267181 D 171101 CDS NP_358868.1 15903318 934485 complement(1270613..1271164) 1 NC_003098.1 alanine acetyl transferase; hypothetical protein 1271164 934485 spr1275 Streptococcus pneumoniae R6 hypothetical protein NP_358868.1 1270613 R 171101 CDS NP_358869.1 15903319 934488 complement(1271411..1272235) 1 NC_003098.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1272235 nadE 934488 nadE Streptococcus pneumoniae R6 NAD synthetase NP_358869.1 1271411 R 171101 CDS NP_358870.1 15903320 934497 complement(1272232..1273692) 1 NC_003098.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1273692 934497 spr1277 Streptococcus pneumoniae R6 nicotinate phosphoribosyltransferase NP_358870.1 1272232 R 171101 CDS NP_358871.1 15903321 934492 complement(1273808..1274296) 1 NC_003098.1 hypothetical protein 1274296 934492 spr1278 Streptococcus pneumoniae R6 hypothetical protein NP_358871.1 1273808 R 171101 CDS NP_358872.1 15903322 934498 complement(1274286..1274525) 1 NC_003098.1 transcription regulator; transcriptional repressor 1274525 934498 spr1279 Streptococcus pneumoniae R6 transcriptional repressor NP_358872.1 1274286 R 171101 CDS NP_358873.1 15903323 934501 complement(1274880..1275608) 1 NC_003098.1 hypothetical protein 1275608 934501 spr1280 Streptococcus pneumoniae R6 hypothetical protein NP_358873.1 1274880 R 171101 CDS NP_358874.1 15903324 934500 complement(1275624..1276346) 1 NC_003098.1 ABC transporter ATP-binding protein 1276346 ABC-NBD 934500 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358874.1 1275624 R 171101 CDS NP_358875.1 15903325 934491 complement(1276851..1277576) 1 NC_003098.1 hypothetical protein 1277576 934491 spr1282 Streptococcus pneumoniae R6 hypothetical protein NP_358875.1 1276851 R 171101 CDS NP_358877.1 15903327 934494 complement(1278165..1279469) 1 NC_003098.1 protease 1279469 934494 spr1284 Streptococcus pneumoniae R6 protease NP_358877.1 1278165 R 171101 CDS NP_358881.1 15903331 934499 complement(1282334..1283326) 1 NC_003098.1 hypothetical protein 1283326 934499 spr1288 Streptococcus pneumoniae R6 hypothetical protein NP_358881.1 1282334 R 171101 CDS NP_358882.1 15903332 934506 1283480..1285240 1 NC_003098.1 ABC transporter ATP-binding protein/permease 1285240 ABC-N/P 934506 ABC-N/P Streptococcus pneumoniae R6 ABC transporter ATP-binding protein/permease NP_358882.1 1283480 D 171101 CDS NP_358883.1 15903333 934504 1285200..1286945 1 NC_003098.1 ABC transporter ATP-binding protein 1286945 ABC-N/P 934504 ABC-N/P Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358883.1 1285200 D 171101 CDS NP_358884.1 15903334 934511 1286956..1287540 1 NC_003098.1 hypothetical protein 1287540 934511 spr1291 Streptococcus pneumoniae R6 hypothetical protein NP_358884.1 1286956 D 171101 CDS NP_358885.1 15903335 934527 1287540..1288235 1 NC_003098.1 hypothetical protein 1288235 934527 spr1292 Streptococcus pneumoniae R6 hypothetical protein NP_358885.1 1287540 D 171101 CDS NP_358886.1 15903336 934510 1288223..1289587 1 NC_003098.1 ABC transporter ATP-binding protein 1289587 ABC-NBD 934510 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_358886.1 1288223 D 171101 CDS NP_358887.1 15903337 934512 complement(1290375..1290836) 1 NC_003098.1 hypothetical protein 1290836 934512 spr1294 Streptococcus pneumoniae R6 hypothetical protein NP_358887.1 1290375 R 171101 CDS NP_358889.1 15903339 934507 complement(1291130..1291498) 1 NC_003098.1 hypothetical protein 1291498 934507 spr1296 Streptococcus pneumoniae R6 hypothetical protein NP_358889.1 1291130 R 171101 CDS NP_358890.1 15903340 934513 complement(1291422..1291616) 1 NC_003098.1 hypothetical protein 1291616 934513 spr1297 Streptococcus pneumoniae R6 hypothetical protein NP_358890.1 1291422 R 171101 CDS NP_358891.1 15903341 934509 complement(1291786..1292136) 1 NC_003098.1 transposase 1292136 transposase_E 934509 transposase_E Streptococcus pneumoniae R6 transposase NP_358891.1 1291786 R 171101 CDS NP_358893.1 15903343 934514 complement(1292606..1294168) 1 NC_003098.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1294168 guaA 934514 guaA Streptococcus pneumoniae R6 GMP synthase NP_358893.1 1292606 R 171101 CDS NP_358894.1 15903344 934515 1294301..1295008 1 NC_003098.1 Probable transcription regulator, GntR family; hypothetical protein 1295008 934515 spr1301 Streptococcus pneumoniae R6 hypothetical protein NP_358894.1 1294301 D 171101 CDS NP_358895.1 15903345 934519 complement(1295051..1296007) 1 NC_003098.1 membrane protein; hypothetical protein 1296007 934519 spr1302 Streptococcus pneumoniae R6 hypothetical protein NP_358895.1 1295051 R 171101 CDS NP_358896.1 15903346 934520 complement(1295956..1296894) 1 NC_003098.1 hypothetical protein 1296894 934520 spr1303 Streptococcus pneumoniae R6 hypothetical protein NP_358896.1 1295956 R 171101 CDS NP_358897.1 15903347 934516 complement(1296891..1297631) 1 NC_003098.1 C3-degrading proteinase 1297631 cppA 934516 cppA Streptococcus pneumoniae R6 C3-degrading proteinase NP_358897.1 1296891 R 171101 CDS NP_358898.1 15903348 934524 complement(1297700..1298335) 1 NC_003098.1 hypothetical protein 1298335 934524 spr1305 Streptococcus pneumoniae R6 hypothetical protein NP_358898.1 1297700 R 171101 CDS NP_358899.1 15903349 934518 complement(1298337..1299164) 1 NC_003098.1 Cof family protein 1299164 934518 spr1306 Streptococcus pneumoniae R6 Cof family protein NP_358899.1 1298337 R 171101 CDS NP_358903.1 15903353 934523 1300763..1301374 1 NC_003098.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1301374 def 934523 def Streptococcus pneumoniae R6 peptide deformylase NP_358903.1 1300763 D 171101 CDS NP_358904.1 15903354 934536 1301386..1302147 1 NC_003098.1 tRNA (guanosine-2'-O-)-methyltransferase 1302147 trmH 934536 trmH Streptococcus pneumoniae R6 tRNA (guanosine-2'-O-)-methyltransferase NP_358904.1 1301386 D 171101 CDS NP_358905.1 15903355 934526 complement(1302186..1303097) 1 NC_003098.1 thioredoxin reductase 1303097 trxB 934526 trxB Streptococcus pneumoniae R6 thioredoxin reductase NP_358905.1 1302186 R 171101 CDS NP_358906.1 15903356 934525 complement(1303163..1303399) 1 NC_003098.1 hypothetical protein 1303399 934525 spr1313 Streptococcus pneumoniae R6 hypothetical protein NP_358906.1 1303163 R 171101 CDS NP_358907.1 15903357 934534 complement(1303465..1304208) 1 NC_003098.1 amino acid ABC transporter ATP-binding protein 1304208 ABC-NDB 934534 ABC-NDB Streptococcus pneumoniae R6 amino acid ABC transporter ATP-binding protein NP_358907.1 1303465 R 171101 CDS NP_358908.1 15903358 934533 complement(1304208..1305008) 1 NC_003098.1 amino acid ABC transporter permease 1305008 ABC-MSP 934533 ABC-MSP Streptococcus pneumoniae R6 amino acid ABC transporter permease NP_358908.1 1304208 R 171101 CDS NP_358909.1 15903359 934529 complement(1305166..1305522) 1 NC_003098.1 Similar to arsenate reductase; hypothetical protein 1305522 934529 spr1316 Streptococcus pneumoniae R6 hypothetical protein NP_358909.1 1305166 R 171101 CDS NP_358910.1 15903360 934535 complement(1305516..1306046) 1 NC_003098.1 methylated-DNA--protein-cysteine S-methyltransferase 1306046 ogt 934535 ogt Streptococcus pneumoniae R6 methylated-DNA--protein-cysteine S-methyltransferase NP_358910.1 1305516 R 171101 CDS NP_358911.1 15903361 934530 complement(1306046..1306540) 1 NC_003098.1 acetyltransferase; hypothetical protein 1306540 934530 spr1318 Streptococcus pneumoniae R6 hypothetical protein NP_358911.1 1306046 R 171101 CDS NP_358912.1 15903362 934531 1306669..1307121 1 NC_003098.1 hypothetical protein 1307121 934531 spr1319 Streptococcus pneumoniae R6 hypothetical protein NP_358912.1 1306669 D 171101 CDS NP_358913.1 15903363 934541 1307118..1307765 1 NC_003098.1 Similar to hemolysin III; hemolysin 1307765 934541 spr1320 Streptococcus pneumoniae R6 hemolysin NP_358913.1 1307118 D 171101 CDS NP_358914.1 15903364 934544 complement(1307786..1308367) 1 NC_003098.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 1308367 934544 spr1321 Streptococcus pneumoniae R6 glutamine amidotransferase subunit PdxT NP_358914.1 1307786 R 171101 CDS NP_358915.1 15903365 934532 complement(1308368..1309261) 1 NC_003098.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 1309261 pdx1 934532 pdx1 Streptococcus pneumoniae R6 pyridoxal biosynthesis lyase PdxS NP_358915.1 1308368 R 171101 CDS NP_358916.1 15903366 934540 complement(1309395..1310774) 1 NC_003098.1 NADH oxidase 1310774 nox 934540 nox Streptococcus pneumoniae R6 NADH oxidase NP_358916.1 1309395 R 171101 CDS NP_358917.1 15903367 934537 1311068..1311991 1 NC_003098.1 thiamine biosynthesis protein ApbE 1311991 apbE 934537 apbE Streptococcus pneumoniae R6 thiamine biosynthesis protein ApbE NP_358917.1 1311068 D 171101 CDS NP_358918.1 15903368 934542 1312051..1312656 1 NC_003098.1 hypothetical protein 1312656 934542 spr1325 Streptococcus pneumoniae R6 hypothetical protein NP_358918.1 1312051 D 171101 CDS NP_358919.1 15903369 934543 1312674..1313918 1 NC_003098.1 oxidoreductase 1313918 934543 spr1326 Streptococcus pneumoniae R6 oxidoreductase NP_358919.1 1312674 D 171101 CDS NP_358920.1 15903370 934539 complement(1314035..1314292) 1 NC_003098.1 hypothetical protein 1314292 934539 spr1327 Streptococcus pneumoniae R6 hypothetical protein NP_358920.1 1314035 R 171101 CDS NP_358921.1 15903371 934538 complement(1314334..1316370) 1 NC_003098.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 1316370 glyS 934538 glyS Streptococcus pneumoniae R6 glycyl-tRNA synthetase subunit beta NP_358921.1 1314334 R 171101 CDS NP_358922.1 15903372 934548 complement(1316630..1317547) 1 NC_003098.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 1317547 glyQ 934548 glyQ Streptococcus pneumoniae R6 glycyl-tRNA synthetase subunit alpha NP_358922.1 1316630 R 171101 CDS NP_358925.1 15903375 934550 complement(1318774..1319616) 1 NC_003098.1 oxidoreductase; hypothetical protein 1319616 934550 spr1332 Streptococcus pneumoniae R6 hypothetical protein NP_358925.1 1318774 R 171101 CDS NP_358926.1 15903376 934547 complement(1319730..1321121) 1 NC_003098.1 peptidoglycan GlcNAc deacetylase 1321121 pgdA 934547 pgdA Streptococcus pneumoniae R6 peptidoglycan GlcNAc deacetylase NP_358926.1 1319730 R 171101 CDS NP_358928.1 15903378 934555 1321864..1322925 1 NC_003098.1 oxidoreductase 1322925 mocA 934555 mocA Streptococcus pneumoniae R6 oxidoreductase NP_358928.1 1321864 D 171101 CDS NP_358929.1 15903379 934554 1322922..1324004 1 NC_003098.1 DEAD RNA helicase 1324004 DEAD/H 934554 DEAD/H Streptococcus pneumoniae R6 DEAD RNA helicase NP_358929.1 1322922 D 171101 CDS NP_358936.1 15903386 934560 complement(1326964..1328160) 1 NC_003098.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1328160 tuf 934560 tuf Streptococcus pneumoniae R6 elongation factor Tu NP_358936.1 1326964 R 171101 CDS NP_358937.1 15903387 934564 complement(1329082..1329951) 1 NC_003098.1 glycerol uptake facilitator protein 1329951 glpF 934564 glpF Streptococcus pneumoniae R6 glycerol uptake facilitator protein NP_358937.1 1329082 R 171101 CDS NP_358938.1 15903388 934589 complement(1330175..1330783) 1 NC_003098.1 cell wall surface anchor family protein 1330783 934589 spr1345 Streptococcus pneumoniae R6 cell wall surface anchor family protein NP_358938.1 1330175 R 171101 CDS NP_358939.1 15903389 934559 complement(1330741..1331853) 1 NC_003098.1 hypothetical protein 1331853 934559 spr1346 Streptococcus pneumoniae R6 hypothetical protein NP_358939.1 1330741 R 171101 CDS NP_358940.1 15903390 934567 complement(1331958..1332212) 1 NC_003098.1 hypothetical protein 1332212 934567 spr1347 Streptococcus pneumoniae R6 hypothetical protein NP_358940.1 1331958 R 171101 CDS NP_358941.1 15903391 934562 complement(1332206..1332448) 1 NC_003098.1 hypothetical protein 1332448 934562 spr1348 Streptococcus pneumoniae R6 hypothetical protein NP_358941.1 1332206 R 171101 CDS NP_358944.1 15903394 934575 1333648..1335366 1 NC_003098.1 phosphoglucomutase 1335366 pgm 934575 pgm Streptococcus pneumoniae R6 phosphoglucomutase NP_358944.1 1333648 D 171101 CDS NP_358945.1 15903395 934565 1335477..1335824 1 NC_003098.1 bacterocin transport accessory protein 1335824 bta 934565 bta Streptococcus pneumoniae R6 bacterocin transport accessory protein NP_358945.1 1335477 D 171101 CDS NP_358946.1 15903396 934569 complement(1336103..1336939) 1 NC_003098.1 amino acid ABC transporter amino acid-binding protein 1336939 glnH 934569 glnH Streptococcus pneumoniae R6 amino acid ABC transporter amino acid-binding protein NP_358946.1 1336103 R 171101 CDS NP_358947.1 15903397 934568 complement(1336952..1337581) 1 NC_003098.1 amino acid ABC transporter ATP-binding protein 1337581 glnQ 934568 glnQ Streptococcus pneumoniae R6 amino acid ABC transporter ATP-binding protein NP_358947.1 1336952 R 171101 CDS NP_358948.1 15903398 934570 complement(1337591..1338289) 1 NC_003098.1 amino acid ABC transporter permease 1338289 glnP 934570 glnP Streptococcus pneumoniae R6 amino acid ABC transporter permease NP_358948.1 1337591 R 171101 CDS NP_358949.1 15903399 934578 complement(1338378..1339622) 1 NC_003098.1 hypothetical protein 1339622 934578 spr1356 Streptococcus pneumoniae R6 hypothetical protein NP_358949.1 1338378 R 171101 CDS NP_358950.1 15903400 934574 complement(1339597..1340763) 1 NC_003098.1 membrane protein; hypothetical protein 1340763 934574 spr1357 Streptococcus pneumoniae R6 hypothetical protein NP_358950.1 1339597 R 171101 CDS NP_358951.1 15903401 934572 1340907..1341920 1 NC_003098.1 hypothetical protein 1341920 934572 spr1358 Streptococcus pneumoniae R6 hypothetical protein NP_358951.1 1340907 D 171101 CDS NP_358952.1 15903402 934577 complement(1341965..1342384) 1 NC_003098.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 1342384 atpC 934577 atpC Streptococcus pneumoniae R6 ATP synthase F0F1 subunit epsilon NP_358952.1 1341965 R 171101 CDS NP_358953.1 15903403 934571 complement(1342395..1343801) 1 NC_003098.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 1343801 atpD 934571 atpD Streptococcus pneumoniae R6 ATP synthase F0F1 subunit beta NP_358953.1 1342395 R 171101 CDS NP_358954.1 15903404 934573 complement(1343887..1344765) 1 NC_003098.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 1344765 atpG 934573 atpG Streptococcus pneumoniae R6 ATP synthase F0F1 subunit gamma NP_358954.1 1343887 R 171101 CDS NP_358955.1 15903405 934581 complement(1344781..1346286) 1 NC_003098.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 1346286 atpA 934581 atpA Streptococcus pneumoniae R6 ATP synthase F0F1 subunit alpha NP_358955.1 1344781 R 171101 CDS NP_358956.1 15903406 934579 complement(1346301..1346837) 1 NC_003098.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 1346837 atpH 934579 atpH Streptococcus pneumoniae R6 ATP synthase F0F1 subunit delta NP_358956.1 1346301 R 171101 CDS NP_358957.1 15903407 934576 complement(1346837..1347331) 1 NC_003098.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 1347331 atpF 934576 atpF Streptococcus pneumoniae R6 ATP synthase F0F1 subunit B NP_358957.1 1346837 R 171101 CDS NP_358958.1 15903408 934583 complement(1347345..1348061) 1 NC_003098.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 1348061 atpB 934583 atpB Streptococcus pneumoniae R6 ATP synthase F0F1 subunit A NP_358958.1 1347345 R 171101 CDS NP_358959.1 15903409 934580 complement(1348096..1348296) 1 NC_003098.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 1348296 atpE 934580 atpE Streptococcus pneumoniae R6 ATP synthase F0F1 subunit C NP_358959.1 1348096 R 171101 CDS NP_358960.1 15903410 934582 complement(1348371..1349378) 1 NC_003098.1 transposase 1349378 IS1239 934582 IS1239 Streptococcus pneumoniae R6 transposase NP_358960.1 1348371 R 171101 CDS NP_358961.1 15903411 934587 complement(1349823..1350305) 1 NC_003098.1 hypothetical protein 1350305 934587 spr1368 Streptococcus pneumoniae R6 hypothetical protein NP_358961.1 1349823 R 171101 CDS NP_358962.1 15903412 934588 complement(1350774..1351265) 1 NC_003098.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1351265 greA 934588 greA Streptococcus pneumoniae R6 transcription elongation factor GreA NP_358962.1 1350774 R 171101 CDS NP_358963.1 15903413 934585 complement(1351327..1352982) 1 NC_003098.1 hypothetical protein 1352982 934585 spr1370 Streptococcus pneumoniae R6 hypothetical protein NP_358963.1 1351327 R 171101 CDS NP_358964.1 15903414 934584 complement(1353063..1353557) 1 NC_003098.1 acetyltransferase; hypothetical protein 1353557 934584 spr1371 Streptococcus pneumoniae R6 hypothetical protein NP_358964.1 1353063 R 171101 CDS NP_358965.1 15903415 934592 complement(1353554..1354018) 1 NC_003098.1 N-terminal acetyltransferase related protein; hypothetical protein 1354018 934592 spr1372 Streptococcus pneumoniae R6 hypothetical protein NP_358965.1 1353554 R 171101 CDS NP_358966.1 15903416 934586 complement(1354028..1355362) 1 NC_003098.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1355362 murC 934586 murC Streptococcus pneumoniae R6 UDP-N-acetylmuramate--L-alanine ligase NP_358966.1 1354028 R 171101 CDS NP_358967.1 15903417 934590 complement(1355373..1355990) 1 NC_003098.1 hypothetical protein 1355990 934590 spr1374 Streptococcus pneumoniae R6 hypothetical protein NP_358967.1 1355373 R 171101 CDS NP_358968.1 15903418 934596 complement(1356038..1359136) 1 NC_003098.1 Snf2 family protein 1359136 snf 934596 snf Streptococcus pneumoniae R6 Snf2 family protein NP_358968.1 1356038 R 171101 CDS NP_358969.1 15903419 934591 complement(1359229..1360395) 1 NC_003098.1 aminotransferase, class II 1360395 patB 934591 patB Streptococcus pneumoniae R6 aminotransferase, class II NP_358969.1 1359229 R 171101 CDS NP_358970.1 15903420 934621 complement(1360403..1361497) 1 NC_003098.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 1361497 metB 934621 metB Streptococcus pneumoniae R6 cystathionine gamma-synthase NP_358970.1 1360403 R 171101 CDS NP_358975.1 15903425 934595 complement(1363510..1365468) 1 NC_003098.1 peptide ABC transporter substrate-binding protein 1365468 aliB 934595 aliB Streptococcus pneumoniae R6 peptide ABC transporter substrate-binding protein NP_358975.1 1363510 R 171101 CDS NP_358976.1 15903426 934598 complement(1365671..1367293) 1 NC_003098.1 polysaccharide biosynthesis protein 1367293 PST_transporter 934598 PST_transporter Streptococcus pneumoniae R6 polysaccharide biosynthesis protein NP_358976.1 1365671 R 171101 CDS NP_358977.1 15903427 934603 1367399..1368844 1 NC_003098.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1368844 murE 934603 murE Streptococcus pneumoniae R6 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase NP_358977.1 1367399 D 171101 CDS NP_358978.1 15903428 934607 complement(1368890..1369084) 1 NC_003098.1 hypothetical protein 1369084 934607 spr1385 Streptococcus pneumoniae R6 hypothetical protein NP_358978.1 1368890 R 171101 CDS NP_358981.1 15903431 934601 complement(1369817..1370329) 1 NC_003098.1 hypothetical protein 1370329 934601 spr1388 Streptococcus pneumoniae R6 hypothetical protein NP_358981.1 1369817 R 171101 CDS NP_358982.1 15903432 934602 complement(1370416..1371351) 1 NC_003098.1 catalyzes the hydrolysis of pyrophosphate to phosphate; manganese-dependent inorganic pyrophosphatase 1371351 ppaC 934602 ppaC Streptococcus pneumoniae R6 manganese-dependent inorganic pyrophosphatase NP_358982.1 1370416 R 171101 CDS NP_358983.1 15903433 934610 complement(1371422..1371721) 1 NC_003098.1 hypothetical protein 1371721 934610 spr1390 Streptococcus pneumoniae R6 hypothetical protein NP_358983.1 1371422 R 171101 CDS NP_358984.1 15903434 934604 complement(1371711..1372460) 1 NC_003098.1 hypothetical protein 1372460 934604 spr1391 Streptococcus pneumoniae R6 hypothetical protein NP_358984.1 1371711 R 171101 CDS NP_358985.1 15903435 934608 complement(1372514..1372900) 1 NC_003098.1 Similar to general stress protein GSP13 from Lactococcus lactis subsp. lactis and Bacillus subtilis; hypothetical protein 1372900 934608 spr1392 Streptococcus pneumoniae R6 hypothetical protein NP_358985.1 1372514 R 171101 CDS NP_358986.1 15903436 934612 complement(1372875..1374275) 1 NC_003098.1 Cof family protein/peptidyl-prolyl cis-trans isomerase 1374275 934612 spr1393 Streptococcus pneumoniae R6 Cof family protein/peptidyl-prolyl cis-trans isomerase NP_358986.1 1372875 R 171101 CDS NP_358987.1 15903437 934606 complement(1374570..1374809) 1 NC_003098.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 1374809 rpsR 934606 rpsR Streptococcus pneumoniae R6 30S ribosomal protein S18 NP_358987.1 1374570 R 171101 CDS NP_358988.1 15903438 934609 complement(1374841..1375311) 1 NC_003098.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1375311 ssbA 934609 ssbA Streptococcus pneumoniae R6 single-stranded DNA-binding protein NP_358988.1 1374841 R 171101 CDS NP_358989.1 15903439 934613 complement(1375323..1375613) 1 NC_003098.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 1375613 rpsF 934613 rpsF Streptococcus pneumoniae R6 30S ribosomal protein S6 NP_358989.1 1375323 R 171101 CDS NP_358990.1 15903440 934611 complement(1375766..1377109) 1 NC_003098.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1377109 asnC 934611 asnC Streptococcus pneumoniae R6 asparaginyl-tRNA synthetase NP_358990.1 1375766 R 171101 CDS NP_358991.1 15903441 934615 complement(1377128..1377499) 1 NC_003098.1 hypothetical protein 1377499 934615 spr1398 Streptococcus pneumoniae R6 hypothetical protein NP_358991.1 1377128 R 171101 CDS NP_358992.1 15903442 934622 complement(1377486..1378673) 1 NC_003098.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 1378673 aspB 934622 aspB Streptococcus pneumoniae R6 aspartate aminotransferase NP_358992.1 1377486 R 171101 CDS NP_358993.1 15903443 934614 complement(1378670..1379158) 1 NC_003098.1 hypothetical protein 1379158 934614 spr1400 Streptococcus pneumoniae R6 hypothetical protein NP_358993.1 1378670 R 171101 CDS NP_358995.1 15903445 934619 1379398..1380027 1 NC_003098.1 hypothetical protein 1380027 934619 spr1402 Streptococcus pneumoniae R6 hypothetical protein NP_358995.1 1379398 D 171101 CDS NP_358996.1 15903446 934616 complement(1380265..1387920) 1 NC_003098.1 hypothetical protein 1387920 934616 spr1403 Streptococcus pneumoniae R6 hypothetical protein NP_358996.1 1380265 R 171101 CDS NP_358997.1 15903447 934617 1388112..1389620 1 NC_003098.1 Mga-like regulatory protein; hypothetical protein 1389620 934617 spr1404 Streptococcus pneumoniae R6 hypothetical protein NP_358997.1 1388112 D 171101 CDS NP_358998.1 15903448 934628 complement(1389671..1390399) 1 NC_003098.1 hypothetical protein 1390399 934628 spr1405 Streptococcus pneumoniae R6 hypothetical protein NP_358998.1 1389671 R 171101 CDS NP_358999.1 15903449 934620 complement(1390478..1390657) 1 NC_003098.1 hypothetical protein 1390657 934620 spr1406 Streptococcus pneumoniae R6 hypothetical protein NP_358999.1 1390478 R 171101 CDS NP_359000.1 15903450 934168 complement(1390809..1392404) 1 NC_003098.1 hypothetical protein 1392404 934168 spr1407 Streptococcus pneumoniae R6 hypothetical protein NP_359000.1 1390809 R 171101 CDS NP_359001.1 15903451 934624 complement(1392416..1392826) 1 NC_003098.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1392826 def 934624 def Streptococcus pneumoniae R6 peptide deformylase NP_359001.1 1392416 R 171101 CDS NP_359002.1 15903452 934623 complement(1392942..1393733) 1 NC_003098.1 YghU; B2989; one of eight glutathione transferases from E. coli; glutathione S-transferase YghU 1393733 934623 spr1409 Streptococcus pneumoniae R6 glutathione S-transferase YghU NP_359002.1 1392942 R 171101 CDS NP_359003.1 15903453 934079 complement(1393746..1396442) 1 NC_003098.1 calcium transporter; calcium transporter P-type ATPase 1396442 pacL 934079 pacL Streptococcus pneumoniae R6 calcium transporter P-type ATPase NP_359003.1 1393746 R 171101 CDS NP_359004.1 15903454 934626 1396746..1397930 1 NC_003098.1 Probable cation transporter; cation efflux family protein 1397930 934626 spr1411 Streptococcus pneumoniae R6 cation efflux family protein NP_359004.1 1396746 D 171101 CDS NP_359005.1 15903455 934166 complement(1398073..1399944) 1 NC_003098.1 ABC transporter ATP-binding protein 1399944 ABC-NBD 934166 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_359005.1 1398073 R 171101 CDS NP_359006.1 15903456 934161 complement(1399941..1401140) 1 NC_003098.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 1401140 cca 934161 cca Streptococcus pneumoniae R6 tRNA CCA-pyrophosphorylase NP_359006.1 1399941 R 171101 CDS NP_359007.1 15903457 934164 complement(1401137..1401904) 1 NC_003098.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 1401904 dapB 934164 dapB Streptococcus pneumoniae R6 dihydrodipicolinate reductase NP_359007.1 1401137 R 171101 CDS NP_359008.1 15903458 934169 complement(1402181..1403029) 1 NC_003098.1 Similar to DegV of B.subtilis; hypothetical protein 1403029 934169 spr1415 Streptococcus pneumoniae R6 hypothetical protein NP_359008.1 1402181 R 171101 CDS NP_359009.1 15903459 933090 complement(1403031..1403417) 1 NC_003098.1 hypothetical protein 1403417 933090 spr1416 Streptococcus pneumoniae R6 hypothetical protein NP_359009.1 1403031 R 171101 CDS NP_359010.1 15903460 934084 complement(1403479..1404831) 1 NC_003098.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1404831 glmM 934084 glmM Streptococcus pneumoniae R6 phosphoglucosamine mutase NP_359010.1 1403479 R 171101 CDS NP_359011.1 15903461 933941 complement(1404855..1405634) 1 NC_003098.1 hypothetical protein 1405634 933941 spr1418 Streptococcus pneumoniae R6 hypothetical protein NP_359011.1 1404855 R 171101 CDS NP_359012.1 15903462 934085 complement(1405621..1406499) 1 NC_003098.1 hypothetical protein 1406499 934085 spr1419 Streptococcus pneumoniae R6 hypothetical protein NP_359012.1 1405621 R 171101 CDS NP_359013.1 15903463 933883 complement(1406396..1406569) 1 NC_003098.1 hypothetical protein 1406569 933883 spr1420 Streptococcus pneumoniae R6 hypothetical protein NP_359013.1 1406396 R 171101 CDS NP_359014.1 15903464 934042 1406614..1407582 1 NC_003098.1 pyridine nucleotide-disulphide oxidoreductase 1407582 trxB 934042 trxB Streptococcus pneumoniae R6 pyridine nucleotide-disulphide oxidoreductase NP_359014.1 1406614 D 171101 CDS NP_359015.1 15903465 934044 complement(1407616..1408527) 1 NC_003098.1 hypothetical protein 1408527 934044 spr1422 Streptococcus pneumoniae R6 hypothetical protein NP_359015.1 1407616 R 171101 CDS NP_359016.1 15903466 934065 complement(1408524..1409501) 1 NC_003098.1 hypothetical protein 1409501 934065 spr1423 Streptococcus pneumoniae R6 hypothetical protein NP_359016.1 1408524 R 171101 CDS NP_359017.1 15903467 934082 complement(1409498..1410388) 1 NC_003098.1 hypothetical protein 1410388 934082 spr1424 Streptococcus pneumoniae R6 hypothetical protein NP_359017.1 1409498 R 171101 CDS NP_359018.1 15903468 933389 complement(1410440..1410820) 1 NC_003098.1 endoribonuclease L-PSP 1410820 aldR 933389 aldR Streptococcus pneumoniae R6 endoribonuclease L-PSP NP_359018.1 1410440 R 171101 CDS NP_359019.1 15903469 933284 complement(1410831..1411424) 1 NC_003098.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 1411424 engB 933284 engB Streptococcus pneumoniae R6 ribosome biogenesis GTP-binding protein YsxC NP_359019.1 1410831 R 171101 CDS NP_359020.1 15903470 933131 complement(1411427..1412659) 1 NC_003098.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1412659 clpX 933131 clpX Streptococcus pneumoniae R6 ATP-dependent protease ATP-binding subunit ClpX NP_359020.1 1411427 R 171101 CDS NP_359021.1 15903471 933094 complement(1412691..1412861) 1 NC_003098.1 hypothetical protein 1412861 933094 spr1428 Streptococcus pneumoniae R6 hypothetical protein NP_359021.1 1412691 R 171101 CDS NP_359022.1 15903472 933011 complement(1412861..1413367) 1 NC_003098.1 dihydrofolate reductase 1413367 dfr 933011 dfr Streptococcus pneumoniae R6 dihydrofolate reductase NP_359022.1 1412861 R 171101 CDS NP_359023.1 15903473 933945 complement(1413497..1414033) 1 NC_003098.1 non-heme iron-containing ferritin 1414033 dpr 933945 dpr Streptococcus pneumoniae R6 non-heme iron-containing ferritin NP_359023.1 1413497 R 171101 CDS NP_359024.1 15903474 933163 complement(1414511..1416016) 1 NC_003098.1 1,4-beta-N-acetylmuramidase 1416016 lytC 933163 lytC Streptococcus pneumoniae R6 1,4-beta-N-acetylmuramidase NP_359024.1 1414511 R 171101 CDS NP_359025.1 15903475 933104 complement(1416054..1416833) 1 NC_003098.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1416833 tpiA 933104 tpiA Streptococcus pneumoniae R6 triosephosphate isomerase NP_359025.1 1416054 R 171101 CDS NP_359026.1 15903476 933431 complement(1416910..1417587) 1 NC_003098.1 hypothetical protein 1417587 933431 spr1433 Streptococcus pneumoniae R6 hypothetical protein NP_359026.1 1416910 R 171101 CDS NP_359027.1 15903477 933387 complement(1417596..1418540) 1 NC_003098.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 1418540 metA 933387 metA Streptococcus pneumoniae R6 homoserine O-succinyltransferase NP_359027.1 1417596 R 171101 CDS NP_359028.1 15903478 933430 complement(1418722..1419252) 1 NC_003098.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1419252 apt 933430 apt Streptococcus pneumoniae R6 adenine phosphoribosyltransferase NP_359028.1 1418722 R 171101 CDS NP_359029.1 15903479 933409 complement(1419322..1420080) 1 NC_003098.1 Methyltransferase-like protein; hypothetical protein 1420080 933409 spr1436 Streptococcus pneumoniae R6 hypothetical protein NP_359029.1 1419322 R 171101 CDS NP_359030.1 15903480 933410 complement(1420581..1421711) 1 NC_003098.1 sugar ABC transporter ATP-binding protein 1421711 msmK 933410 msmK Streptococcus pneumoniae R6 sugar ABC transporter ATP-binding protein NP_359030.1 1420581 R 171101 CDS NP_359031.1 15903481 933750 complement(1422161..1422736) 1 NC_003098.1 isochorismatase 1422736 entB 933750 entB Streptococcus pneumoniae R6 isochorismatase NP_359031.1 1422161 R 171101 CDS NP_359032.1 15903482 933916 complement(1422736..1423524) 1 NC_003098.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY 1423524 codY 933916 codY Streptococcus pneumoniae R6 transcriptional repressor CodY NP_359032.1 1422736 R 171101 CDS NP_359033.1 15903483 933241 complement(1423788..1425362) 1 NC_003098.1 Probable ATP-dependent RNA helicase; ATP-dependent RNA helicase 1425362 933241 spr1440 Streptococcus pneumoniae R6 ATP-dependent RNA helicase NP_359033.1 1423788 R 171101 CDS NP_359034.1 15903484 933237 complement(1425561..1426787) 1 NC_003098.1 oxalate:formate antiporter 1426787 oxlT 933237 oxlT Streptococcus pneumoniae R6 oxalate:formate antiporter NP_359034.1 1425561 R 171101 CDS NP_359035.1 15903485 933259 1426977..1428293 1 NC_003098.1 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 1428293 merA 933259 merA Streptococcus pneumoniae R6 pyridine nucleotide-disulfide oxidoreductase NP_359035.1 1426977 D 171101 CDS NP_359036.1 15903486 933333 1428392..1429735 1 NC_003098.1 three-substrate amide ligase belonging tothe mur-ligase; hypothetical protein 1429735 933333 spr1443 Streptococcus pneumoniae R6 hypothetical protein NP_359036.1 1428392 D 171101 CDS NP_359037.1 15903487 933453 1429735..1430517 1 NC_003098.1 hypothetical protein 1430517 cobQ 933453 cobQ Streptococcus pneumoniae R6 hypothetical protein NP_359037.1 1429735 D 171101 CDS NP_359038.1 15903488 933393 1430643..1431725 1 NC_003098.1 dipeptidase 1431725 pepQ 933393 pepQ Streptococcus pneumoniae R6 dipeptidase NP_359038.1 1430643 D 171101 CDS NP_359039.1 15903489 933278 complement(1432048..1432536) 1 NC_003098.1 integrase 1432536 933278 spr1446 Streptococcus pneumoniae R6 integrase NP_359039.1 1432048 R 171101 CDS NP_359040.1 15903490 933311 complement(1432598..1432870) 1 NC_003098.1 hypothetical protein 1432870 933311 spr1447 Streptococcus pneumoniae R6 hypothetical protein NP_359040.1 1432598 R 171101 CDS NP_359041.1 15903491 932992 complement(1433096..1433368) 1 NC_003098.1 hypothetical protein 1433368 932992 spr1448 Streptococcus pneumoniae R6 hypothetical protein NP_359041.1 1433096 R 171101 CDS NP_359042.1 15903492 933240 complement(1433540..1434001) 1 NC_003098.1 hypothetical protein 1434001 933240 spr1449 Streptococcus pneumoniae R6 hypothetical protein NP_359042.1 1433540 R 171101 CDS NP_359043.1 15903493 933776 complement(1433979..1434752) 1 NC_003098.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 1434752 pdxK 933776 pdxK Streptococcus pneumoniae R6 phosphomethylpyrimidine kinase NP_359043.1 1433979 R 171101 CDS NP_359044.1 15903494 933799 complement(1434742..1435491) 1 NC_003098.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1435491 truA 933799 truA Streptococcus pneumoniae R6 tRNA pseudouridine synthase A NP_359044.1 1434742 R 171101 CDS NP_359046.1 15903496 933474 complement(1435804..1436955) 1 NC_003098.1 major facilitator transporter 1436955 MFS_transporter 933474 MFS_transporter Streptococcus pneumoniae R6 major facilitator transporter NP_359046.1 1435804 R 171101 CDS NP_359047.1 15903497 934038 complement(1437195..1437824) 1 NC_003098.1 hypothetical protein 1437824 934038 spr1454 Streptococcus pneumoniae R6 hypothetical protein NP_359047.1 1437195 R 171101 CDS NP_359048.1 15903498 933081 complement(1437827..1438165) 1 NC_003098.1 hypothetical protein 1438165 phnA 933081 phnA Streptococcus pneumoniae R6 hypothetical protein NP_359048.1 1437827 R 171101 CDS NP_359049.1 15903499 933855 complement(1438296..1438967) 1 NC_003098.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1438967 cmk 933855 cmk Streptococcus pneumoniae R6 cytidylate kinase NP_359049.1 1438296 R 171101 CDS NP_359050.1 15903500 933097 complement(1438976..1439452) 1 NC_003098.1 hypothetical protein 1439452 933097 spr1457 Streptococcus pneumoniae R6 hypothetical protein NP_359050.1 1438976 R 171101 CDS NP_359051.1 15903501 933123 1439432..1439710 1 NC_003098.1 ferredoxin 1439710 fer 933123 fer Streptococcus pneumoniae R6 ferredoxin NP_359051.1 1439432 D 171101 CDS NP_359052.1 15903502 933830 complement(1439772..1440863) 1 NC_003098.1 glycosil transferase 1440863 gtrB 933830 gtrB Streptococcus pneumoniae R6 glycosil transferase NP_359052.1 1439772 R 171101 CDS NP_359053.1 15903503 933804 complement(1440727..1441746) 1 NC_003098.1 UDP-glucose 4-epimerase 1441746 galE 933804 galE Streptococcus pneumoniae R6 UDP-glucose 4-epimerase NP_359053.1 1440727 R 171101 CDS NP_359054.1 15903504 934040 complement(1442047..1443159) 1 NC_003098.1 Probable oxidase; hypothetical protein 1443159 934040 spr1461 Streptococcus pneumoniae R6 hypothetical protein NP_359054.1 1442047 R 171101 CDS NP_359055.1 15903505 933251 complement(1443167..1443964) 1 NC_003098.1 hypothetical protein 1443964 933251 spr1462 Streptococcus pneumoniae R6 hypothetical protein NP_359055.1 1443167 R 171101 CDS NP_359056.1 15903506 933452 complement(1443951..1444628) 1 NC_003098.1 hypothetical protein 1444628 933452 spr1463 Streptococcus pneumoniae R6 hypothetical protein NP_359056.1 1443951 R 171101 CDS NP_359057.1 15903507 934036 complement(1444730..1447066) 1 NC_003098.1 metal cation transporter P-type ATPase 1447066 ctpE 934036 ctpE Streptococcus pneumoniae R6 metal cation transporter P-type ATPase NP_359057.1 1444730 R 171101 CDS NP_359058.1 15903508 933161 1447154..1447948 1 NC_003098.1 Probable member of acyltransferase; hypothetical protein 1447948 933161 spr1465 Streptococcus pneumoniae R6 hypothetical protein NP_359058.1 1447154 D 171101 CDS NP_359059.1 15903509 933449 complement(1448241..1448855) 1 NC_003098.1 cadmium resistance protein 1448855 cadD 933449 cadD Streptococcus pneumoniae R6 cadmium resistance protein NP_359059.1 1448241 R 171101 CDS NP_359060.1 15903510 934037 complement(1449589..1449858) 1 NC_003098.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1449858 rpsO 934037 rpsO Streptococcus pneumoniae R6 30S ribosomal protein S15 NP_359060.1 1449589 R 171101 CDS NP_359061.1 15903511 932978 complement(1449999..1450628) 1 NC_003098.1 hypothetical protein 1450628 932978 spr1468 Streptococcus pneumoniae R6 hypothetical protein NP_359061.1 1449999 R 171101 CDS NP_359065.2 161410743 934039 1451879..1453822 1 NC_003098.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1453822 thrS 934039 thrS Streptococcus pneumoniae R6 threonyl-tRNA synthetase NP_359065.2 1451879 D 171101 CDS NP_359066.1 15903516 933107 complement(1453871..1454845) 1 NC_003098.1 sensor histidine kinase 1454845 hk01 933107 hk01 Streptococcus pneumoniae R6 sensor histidine kinase NP_359066.1 1453871 R 171101 CDS NP_359067.1 15903517 933349 complement(1454838..1455515) 1 NC_003098.1 DNA-binding response regulator 1455515 rr01 933349 rr01 Streptococcus pneumoniae R6 DNA-binding response regulator NP_359067.1 1454838 R 171101 CDS NP_359068.1 15903518 933114 1455671..1456744 1 NC_003098.1 hypothetical protein 1456744 933114 spr1475 Streptococcus pneumoniae R6 hypothetical protein NP_359068.1 1455671 D 171101 CDS NP_359069.1 15903519 933100 complement(1456835..1457137) 1 NC_003098.1 hypothetical protein 1457137 933100 spr1476 Streptococcus pneumoniae R6 hypothetical protein NP_359069.1 1456835 R 171101 CDS NP_359070.1 15903520 934035 complement(1457206..1457643) 1 NC_003098.1 Rrf2 family protein 1457643 934035 spr1477 Streptococcus pneumoniae R6 Rrf2 family protein NP_359070.1 1457206 R 171101 CDS NP_359072.1 15903522 933056 complement(1457719..1458567) 1 NC_003098.1 hypothetical protein 1458567 933056 spr1479 Streptococcus pneumoniae R6 hypothetical protein NP_359072.1 1457719 R 171101 CDS NP_359073.1 15903523 933026 1458673..1459323 1 NC_003098.1 iron-dependent transcriptional regulator 1459323 marR 933026 marR Streptococcus pneumoniae R6 iron-dependent transcriptional regulator NP_359073.1 1458673 D 171101 CDS NP_359074.1 15903524 933112 1459304..1459474 1 NC_003098.1 hypothetical protein 1459474 933112 spr1481 Streptococcus pneumoniae R6 hypothetical protein NP_359074.1 1459304 D 171101 CDS NP_359076.1 15903526 933051 1460276..1460713 1 NC_003098.1 hypothetical protein 1460713 933051 spr1483 Streptococcus pneumoniae R6 hypothetical protein NP_359076.1 1460276 D 171101 CDS NP_359077.1 15903527 933074 complement(1460808..1461107) 1 NC_003098.1 hypothetical protein 1461107 933074 spr1484 Streptococcus pneumoniae R6 hypothetical protein NP_359077.1 1460808 R 171101 CDS NP_359079.1 15903529 933118 complement(1462462..1462905) 1 NC_003098.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 1462905 933118 spr1486 Streptococcus pneumoniae R6 D-tyrosyl-tRNA(Tyr) deacylase NP_359079.1 1462462 R 171101 CDS NP_359080.1 15903530 933127 complement(1462935..1465157) 1 NC_003098.1 GTP pyrophosphokinase 1465157 relA 933127 relA Streptococcus pneumoniae R6 GTP pyrophosphokinase NP_359080.1 1462935 R 171101 CDS NP_359083.1 15903533 933105 1466101..1466781 1 NC_003098.1 Probable member of metallo-beta-lactamase superfamily; metallo-beta-lactamase superfamily protein 1466781 933105 spr1490 Streptococcus pneumoniae R6 metallo-beta-lactamase superfamily protein NP_359083.1 1466101 D 171101 CDS NP_359084.1 15903534 933477 complement(1466904..1468796) 1 NC_003098.1 endopeptidase O 1468796 pepO 933477 pepO Streptococcus pneumoniae R6 endopeptidase O NP_359084.1 1466904 R 171101 CDS NP_359085.1 15903535 933772 1469087..1469809 1 NC_003098.1 manganese ABC transporter ATP-binding protein 1469809 psaB 933772 psaB Streptococcus pneumoniae R6 manganese ABC transporter ATP-binding protein NP_359085.1 1469087 D 171101 CDS NP_359086.1 15903536 933751 1469806..1470654 1 NC_003098.1 manganese ABC transporter permease 1470654 psaC 933751 psaC Streptococcus pneumoniae R6 manganese ABC transporter permease NP_359086.1 1469806 D 171101 CDS NP_359087.1 15903537 933003 1470686..1471615 1 NC_003098.1 manganese ABC transporter substrate-binding protein 1471615 psaA 933003 psaA Streptococcus pneumoniae R6 manganese ABC transporter substrate-binding protein NP_359087.1 1470686 D 171101 CDS NP_359088.2 161410742 933932 1471738..1472229 1 NC_003098.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1472229 tpx 933932 tpx Streptococcus pneumoniae R6 thiol peroxidase NP_359088.2 1471738 D 171101 CDS NP_359089.1 15903539 933117 complement(1472325..1475099) 1 NC_003098.1 hypothetical protein 1475099 933117 spr1496 Streptococcus pneumoniae R6 hypothetical protein NP_359089.1 1472325 R 171101 CDS NP_359090.1 15903540 933758 complement(1475035..1475745) 1 NC_003098.1 ABC transporter ATP-binding protein 1475745 ABC-NBD 933758 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_359090.1 1475035 R 171101 CDS NP_359091.1 15903541 933748 complement(1475986..1478397) 1 NC_003098.1 large secreted protein; hypothetical protein 1478397 933748 spr1498 Streptococcus pneumoniae R6 hypothetical protein NP_359091.1 1475986 R 171101 CDS NP_359092.1 15903542 933138 complement(1478450..1479142) 1 NC_003098.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 1479142 gpmA 933138 gpmA Streptococcus pneumoniae R6 phosphoglyceromutase NP_359092.1 1478450 R 171101 CDS NP_359093.1 15903543 933817 complement(1479193..1479381) 1 NC_003098.1 hypothetical protein 1479381 933817 spr1500 Streptococcus pneumoniae R6 hypothetical protein NP_359093.1 1479193 R 171101 CDS NP_359095.1 15903545 933475 complement(1480465..1483257) 1 NC_003098.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1483257 ileS 933475 ileS Streptococcus pneumoniae R6 isoleucyl-tRNA synthetase NP_359095.1 1480465 R 171101 CDS NP_359096.1 15903546 933024 complement(1483401..1483562) 1 NC_003098.1 hypothetical protein 1483562 933024 spr1503 Streptococcus pneumoniae R6 hypothetical protein NP_359096.1 1483401 R 171101 CDS NP_359098.1 15903548 933446 complement(1483605..1484405) 1 NC_003098.1 cell division protein DivIVA 1484405 divIVA 933446 divIVA Streptococcus pneumoniae R6 cell division protein DivIVA NP_359098.1 1483605 R 171101 CDS NP_359099.1 15903549 933236 complement(1484402..1485253) 1 NC_003098.1 hypothetical protein 1485253 933236 spr1506 Streptococcus pneumoniae R6 hypothetical protein NP_359099.1 1484402 R 171101 CDS NP_359100.1 15903550 934045 complement(1485184..1485447) 1 NC_003098.1 hypothetical protein 1485447 934045 spr1507 Streptococcus pneumoniae R6 hypothetical protein NP_359100.1 1485184 R 171101 CDS NP_359101.1 15903551 933746 complement(1485447..1485986) 1 NC_003098.1 hypothetical protein 1485986 933746 spr1508 Streptococcus pneumoniae R6 hypothetical protein NP_359101.1 1485447 R 171101 CDS NP_359102.1 15903552 933484 complement(1485996..1486667) 1 NC_003098.1 hypothetical protein 1486667 933484 spr1509 Streptococcus pneumoniae R6 hypothetical protein NP_359102.1 1485996 R 171101 CDS NP_359103.1 15903553 933826 complement(1486672..1487931) 1 NC_003098.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1487931 ftsZ 933826 ftsZ Streptococcus pneumoniae R6 cell division protein FtsZ NP_359103.1 1486672 R 171101 CDS NP_359104.1 15903554 933392 complement(1487948..1489321) 1 NC_003098.1 cell division protein FtsA 1489321 ftsA 933392 ftsA Streptococcus pneumoniae R6 cell division protein FtsA NP_359104.1 1487948 R 171101 CDS NP_359105.1 15903555 933008 complement(1489540..1490244) 1 NC_003098.1 hypothetical protein 1490244 933008 spr1512 Streptococcus pneumoniae R6 hypothetical protein NP_359105.1 1489540 R 171101 CDS NP_359106.1 15903556 933010 complement(1490335..1490946) 1 NC_003098.1 MutT/nudix family protein 1490946 mutT 933010 mutT Streptococcus pneumoniae R6 MutT/nudix family protein NP_359106.1 1490335 R 171101 CDS NP_359107.1 15903557 933049 complement(1490933..1492306) 1 NC_003098.1 UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D- alanyl-D-alanine ligase 1492306 murF 933049 murF Streptococcus pneumoniae R6 UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D- alanyl-D-alanine ligase NP_359107.1 1490933 R 171101 CDS NP_359108.1 15903558 933362 complement(1492390..1493433) 1 NC_003098.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 1493433 ddl 933362 ddl Streptococcus pneumoniae R6 D-alanyl-alanine synthetase A NP_359108.1 1492390 R 171101 CDS NP_359109.1 15903559 933153 complement(1493609..1494205) 1 NC_003098.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1494205 recR 933153 recR Streptococcus pneumoniae R6 recombination protein RecR NP_359109.1 1493609 R 171101 CDS NP_359110.1 15903560 933948 complement(1494216..1496273) 1 NC_003098.1 penicillin-binding protein 2B 1496273 pbp2b 933948 pbp2b Streptococcus pneumoniae R6 penicillin-binding protein 2B NP_359110.1 1494216 R 171101 CDS NP_359111.1 15903561 933935 1496473..1497324 1 NC_003098.1 Probable transcriptional regulator; phosphosugar-binding transcriptional regulator 1497324 933935 spr1518 Streptococcus pneumoniae R6 phosphosugar-binding transcriptional regulator NP_359111.1 1496473 D 171101 CDS NP_359112.1 15903562 933382 complement(1497340..1498224) 1 NC_003098.1 ROK family protein 1498224 glk 933382 glk Streptococcus pneumoniae R6 ROK family protein NP_359112.1 1497340 R 171101 CDS NP_359115.1 15903565 933394 complement(1499342..1499806) 1 NC_003098.1 hypothetical protein 1499806 933394 spr1522 Streptococcus pneumoniae R6 hypothetical protein NP_359115.1 1499342 R 171101 CDS NP_359116.1 15903566 933062 complement(1500093..1500437) 1 NC_003098.1 hypothetical protein 1500437 933062 spr1523 Streptococcus pneumoniae R6 hypothetical protein NP_359116.1 1500093 R 171101 CDS NP_359117.1 15903567 933054 complement(1500534..1500986) 1 NC_003098.1 hypothetical protein 1500986 933054 spr1524 Streptococcus pneumoniae R6 hypothetical protein NP_359117.1 1500534 R 171101 CDS NP_359118.1 15903568 933433 complement(1501259..1502098) 1 NC_003098.1 sugar ABC transporter permease 1502098 ABC-MSP 933433 ABC-MSP Streptococcus pneumoniae R6 sugar ABC transporter permease NP_359118.1 1501259 R 171101 CDS NP_359119.1 15903569 933757 complement(1502114..1503010) 1 NC_003098.1 sugar ABC transporter permease 1503010 ABC-MSP 933757 ABC-MSP Streptococcus pneumoniae R6 sugar ABC transporter permease NP_359119.1 1502114 R 171101 CDS NP_359120.1 15903570 933832 complement(1503232..1504560) 1 NC_003098.1 sugar ABC transporter substrate-binding protein 1504560 ABC-SBP 933832 ABC-SBP Streptococcus pneumoniae R6 sugar ABC transporter substrate-binding protein NP_359120.1 1503232 R 171101 CDS NP_359121.1 15903571 933910 complement(1504685..1506217) 1 NC_003098.1 PTS system transporter subunit IIBC 1506217 PTS-EII 933910 PTS-EII Streptococcus pneumoniae R6 PTS system transporter subunit IIBC NP_359121.1 1504685 R 171101 CDS NP_359122.1 15903572 933779 complement(1506221..1506919) 1 NC_003098.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 1506919 nanE 933779 nanE Streptococcus pneumoniae R6 N-acetylmannosamine-6-phosphate 2-epimerase NP_359122.1 1506221 R 171101 CDS NP_359123.1 15903573 933464 complement(1507099..1508202) 1 NC_003098.1 Probable Oxidoreductase, GFO/IDH/MOCA family; hypothetical protein 1508202 933464 spr1530 Streptococcus pneumoniae R6 hypothetical protein NP_359123.1 1507099 R 171101 CDS NP_359124.1 15903574 933504 complement(1508214..1510307) 1 NC_003098.1 neuraminidase B 1510307 nanB 933504 nanB Streptococcus pneumoniae R6 neuraminidase B NP_359124.1 1508214 R 171101 CDS NP_359125.1 15903575 933445 complement(1510325..1511158) 1 NC_003098.1 ABC transporter permease 1511158 ABC-MSP 933445 ABC-MSP Streptococcus pneumoniae R6 ABC transporter permease NP_359125.1 1510325 R 171101 CDS NP_359126.1 15903576 932934 complement(1511158..1512042) 1 NC_003098.1 ABC transporter permease 1512042 ABC-MSP 932934 ABC-MSP Streptococcus pneumoniae R6 ABC transporter permease NP_359126.1 1511158 R 171101 CDS NP_359127.1 15903577 933015 complement(1512121..1513458) 1 NC_003098.1 ABC transporter substrate-binding protein 1513458 ABC-SBP 933015 ABC-SBP Streptococcus pneumoniae R6 ABC transporter substrate-binding protein NP_359127.1 1512121 R 171101 CDS NP_359128.1 15903578 933295 complement(1513477..1513929) 1 NC_003098.1 hypothetical protein 1513929 933295 spr1535 Streptococcus pneumoniae R6 hypothetical protein NP_359128.1 1513477 R 171101 CDS NP_359129.1 15903579 933902 complement(1514944..1518051) 1 NC_003098.1 neuraminidase A 1518051 nanA 933902 nanA Streptococcus pneumoniae R6 neuraminidase A NP_359129.1 1514944 R 171101 CDS NP_359130.1 15903580 933895 complement(1518294..1518521) 1 NC_003098.1 hypothetical protein 1518521 933895 spr1537 Streptococcus pneumoniae R6 hypothetical protein NP_359130.1 1518294 R 171101 CDS NP_359131.1 15903581 933372 complement(1519416..1520396) 1 NC_003098.1 acetyl xylan esterase 1520396 axe1 933372 axe1 Streptococcus pneumoniae R6 acetyl xylan esterase NP_359131.1 1519416 R 171101 CDS NP_359132.1 15903582 933472 complement(1520712..1522727) 1 NC_003098.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 1522727 recG 933472 recG Streptococcus pneumoniae R6 ATP-dependent DNA helicase RecG NP_359132.1 1520712 R 171101 CDS NP_359133.1 15903583 933368 complement(1522746..1523870) 1 NC_003098.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 1523870 alr 933368 alr Streptococcus pneumoniae R6 alanine racemase NP_359133.1 1522746 R 171101 CDS NP_359134.1 15903584 933057 complement(1523839..1524201) 1 NC_003098.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1524201 acpS 933057 acpS Streptococcus pneumoniae R6 4'-phosphopantetheinyl transferase NP_359134.1 1523839 R 171101 CDS NP_359135.1 15903585 932815 complement(1524246..1525277) 1 NC_003098.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1525277 aroF 932815 aroF Streptococcus pneumoniae R6 phospho-2-dehydro-3-deoxyheptonate aldolase NP_359135.1 1524246 R 171101 CDS NP_359136.1 15903586 933155 complement(1525279..1526310) 1 NC_003098.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1526310 aroG 933155 aroG Streptococcus pneumoniae R6 phospho-2-dehydro-3-deoxyheptonate aldolase NP_359136.1 1525279 R 171101 CDS NP_359137.1 15903587 933782 complement(1526391..1528904) 1 NC_003098.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1528904 secA 933782 secA Streptococcus pneumoniae R6 preprotein translocase subunit SecA NP_359137.1 1526391 R 171101 CDS NP_359138.1 15903588 933079 complement(1529050..1529250) 1 NC_003098.1 hypothetical protein 1529250 933079 spr1545 Streptococcus pneumoniae R6 hypothetical protein NP_359138.1 1529050 R 171101 CDS NP_359139.1 15903589 933956 complement(1529350..1530000) 1 NC_003098.1 ABC transporter ATP-binding protein 1530000 ABC-NBD 933956 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_359139.1 1529350 R 171101 CDS NP_359140.1 15903590 933752 complement(1530004..1530681) 1 NC_003098.1 hypothetical protein 1530681 933752 spr1547 Streptococcus pneumoniae R6 hypothetical protein NP_359140.1 1530004 R 171101 CDS NP_359141.1 15903591 933749 complement(1530638..1531429) 1 NC_003098.1 hypothetical protein 1531429 933749 spr1548 Streptococcus pneumoniae R6 hypothetical protein NP_359141.1 1530638 R 171101 CDS NP_359142.1 15903592 933033 complement(1531451..1531843) 1 NC_003098.1 hypothetical protein 1531843 933033 spr1549 Streptococcus pneumoniae R6 hypothetical protein NP_359142.1 1531451 R 171101 CDS NP_359143.1 15903593 933229 1532170..1533021 1 NC_003098.1 Similar to MutR protein; hypothetical protein 1533021 933229 spr1550 Streptococcus pneumoniae R6 hypothetical protein NP_359143.1 1532170 D 171101 CDS NP_359144.1 15903594 933020 complement(1533243..1533596) 1 NC_003098.1 hypothetical protein 1533596 933020 spr1551 Streptococcus pneumoniae R6 hypothetical protein NP_359144.1 1533243 R 171101 CDS NP_359145.1 15903595 932941 complement(1533733..1534077) 1 NC_003098.1 hypothetical protein 1534077 932941 spr1552 Streptococcus pneumoniae R6 hypothetical protein NP_359145.1 1533733 R 171101 CDS NP_359146.1 15903596 933135 complement(1534157..1535467) 1 NC_003098.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1535467 engA 933135 engA Streptococcus pneumoniae R6 GTP-binding protein EngA NP_359146.1 1534157 R 171101 CDS NP_359147.1 15903597 933420 complement(1535481..1536194) 1 NC_003098.1 nitroreductase 1536194 frp 933420 frp Streptococcus pneumoniae R6 nitroreductase NP_359147.1 1535481 R 171101 CDS NP_359148.1 15903598 933865 complement(1536191..1537087) 1 NC_003098.1 Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI 1537087 dnaI 933865 dnaI Streptococcus pneumoniae R6 primosomal protein DnaI NP_359148.1 1536191 R 171101 CDS NP_359149.1 15903599 933424 complement(1537088..1538257) 1 NC_003098.1 hypothetical protein 1538257 dnaB 933424 dnaB Streptococcus pneumoniae R6 hypothetical protein NP_359149.1 1537088 R 171101 CDS NP_359150.2 161410741 933896 complement(1538258..1538731) 1 NC_003098.1 transcriptional regulator NrdR 1538731 nrdR 933896 nrdR Streptococcus pneumoniae R6 transcriptional regulator NrdR NP_359150.2 1538258 R 171101 CDS NP_359151.1 15903601 933463 1538871..1539236 1 NC_003098.1 Similar to transcriptional regulator (GntR family); hypothetical protein 1539236 933463 spr1558 Streptococcus pneumoniae R6 hypothetical protein NP_359151.1 1538871 D 171101 CDS NP_359152.1 15903602 933133 1539214..1539936 1 NC_003098.1 ABC transporter ATP-binding protein 1539936 ABC-NBD 933133 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_359152.1 1539214 D 171101 CDS NP_359153.1 15903603 933149 1539872..1540720 1 NC_003098.1 hypothetical protein 1540720 933149 spr1560 Streptococcus pneumoniae R6 hypothetical protein NP_359153.1 1539872 D 171101 CDS NP_359154.1 15903604 933936 complement(1541133..1542332) 1 NC_003098.1 hypothetical protein 1542332 natB 933936 natB Streptococcus pneumoniae R6 hypothetical protein NP_359154.1 1541133 R 171101 CDS NP_359155.1 15903605 933125 complement(1542329..1543222) 1 NC_003098.1 ABC transporter ATP-binding protein 1543222 natA 933125 natA Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_359155.1 1542329 R 171101 CDS NP_359157.1 15903607 933073 1544531..1545148 1 NC_003098.1 hypothetical protein 1545148 933073 spr1564 Streptococcus pneumoniae R6 hypothetical protein NP_359157.1 1544531 D 171101 CDS NP_359158.1 15903608 933152 complement(1545468..1546355) 1 NC_003098.1 fructokinase 1546355 scrK 933152 scrK Streptococcus pneumoniae R6 fructokinase NP_359158.1 1545468 R 171101 CDS NP_359159.1 15903609 933361 complement(1546504..1548387) 1 NC_003098.1 PTS system transporter subunit IIABC 1548387 scrA 933361 scrA Streptococcus pneumoniae R6 PTS system transporter subunit IIABC NP_359159.1 1546504 R 171101 CDS NP_359160.1 15903610 933454 1548764..1550218 1 NC_003098.1 sucrose-6-phosphate hydrolase 1550218 scrB 933454 scrB Streptococcus pneumoniae R6 sucrose-6-phosphate hydrolase NP_359160.1 1548764 D 171101 CDS NP_359161.1 15903611 933292 1550199..1551164 1 NC_003098.1 sucrose operon repressor 1551164 scrR 933292 scrR Streptococcus pneumoniae R6 sucrose operon repressor NP_359161.1 1550199 D 171101 CDS NP_359162.1 15903612 932918 complement(1551199..1552473) 1 NC_003098.1 3-hydroxy-3-methylglutaryl-CoA reductase 1552473 mvaA 932918 mvaA Streptococcus pneumoniae R6 3-hydroxy-3-methylglutaryl-CoA reductase NP_359162.1 1551199 R 171101 CDS NP_359163.1 15903613 933931 complement(1552473..1553669) 1 NC_003098.1 hydroxymethylglutaryl-CoA synthase 1553669 mvaS 933931 mvaS Streptococcus pneumoniae R6 hydroxymethylglutaryl-CoA synthase NP_359163.1 1552473 R 171101 CDS NP_359164.1 15903614 933874 complement(1553776..1554063) 1 NC_003098.1 hypothetical protein 1554063 933874 spr1572 Streptococcus pneumoniae R6 hypothetical protein NP_359164.1 1553776 R 171101 CDS NP_359165.1 15903615 933925 complement(1554092..1554481) 1 NC_003098.1 tranposase 1554481 IS1381 933925 IS1381 Streptococcus pneumoniae R6 tranposase NP_359165.1 1554092 R 171101 CDS NP_359167.1 15903617 933128 complement(1554780..1555229) 1 NC_003098.1 hypothetical protein 1555229 933128 spr1575 Streptococcus pneumoniae R6 hypothetical protein NP_359167.1 1554780 R 171101 CDS NP_359168.1 15903618 933309 complement(1555231..1555989) 1 NC_003098.1 hypothetical protein 1555989 933309 spr1576 Streptococcus pneumoniae R6 hypothetical protein NP_359168.1 1555231 R 171101 CDS NP_359169.1 15903619 933070 complement(1556104..1558083) 1 NC_003098.1 serine/threonine protein kinase 1558083 pkn2 933070 pkn2 Streptococcus pneumoniae R6 serine/threonine protein kinase NP_359169.1 1556104 R 171101 CDS NP_359170.1 15903620 933328 complement(1558080..1558820) 1 NC_003098.1 phosphatase 1558820 pppL 933328 pppL Streptococcus pneumoniae R6 phosphatase NP_359170.1 1558080 R 171101 CDS NP_359171.1 15903621 933344 complement(1558835..1560151) 1 NC_003098.1 rRNA methylase 1560151 sunL 933344 sunL Streptococcus pneumoniae R6 rRNA methylase NP_359171.1 1558835 R 171101 CDS NP_359172.1 15903622 933459 complement(1560141..1561076) 1 NC_003098.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1561076 fmt 933459 fmt Streptococcus pneumoniae R6 methionyl-tRNA formyltransferase NP_359172.1 1560141 R 171101 CDS NP_359173.1 15903623 933323 complement(1561089..1563485) 1 NC_003098.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1563485 priA 933323 priA Streptococcus pneumoniae R6 primosome assembly protein PriA NP_359173.1 1561089 R 171101 CDS NP_359174.1 15903624 933835 complement(1563551..1563865) 1 NC_003098.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1563865 933835 spr1582 Streptococcus pneumoniae R6 DNA-directed RNA polymerase subunit omega NP_359174.1 1563551 R 171101 CDS NP_359175.1 15903625 933273 complement(1563890..1564516) 1 NC_003098.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1564516 gmk 933273 gmk Streptococcus pneumoniae R6 guanylate kinase NP_359175.1 1563890 R 171101 CDS NP_359176.1 15903626 933269 complement(1564646..1566259) 1 NC_003098.1 hypothetical protein 1566259 933269 spr1584 Streptococcus pneumoniae R6 hypothetical protein NP_359176.1 1564646 R 171101 CDS NP_359177.1 15903627 933264 complement(1566450..1566704) 1 NC_003098.1 hypothetical protein 1566704 933264 spr1585 Streptococcus pneumoniae R6 hypothetical protein NP_359177.1 1566450 R 171101 CDS NP_359178.1 15903628 933314 complement(1566708..1567001) 1 NC_003098.1 hypothetical protein 1567001 933314 spr1586 Streptococcus pneumoniae R6 hypothetical protein NP_359178.1 1566708 R 171101 CDS NP_359179.1 15903629 933243 complement(1567200..1568297) 1 NC_003098.1 hypothetical protein 1568297 933243 spr1587 Streptococcus pneumoniae R6 hypothetical protein NP_359179.1 1567200 R 171101 CDS NP_359180.1 15903630 933287 complement(1568307..1569053) 1 NC_003098.1 hypothetical protein 1569053 933287 spr1588 Streptococcus pneumoniae R6 hypothetical protein NP_359180.1 1568307 R 171101 CDS NP_359181.1 15903631 933139 complement(1569156..1569509) 1 NC_003098.1 iojap-related protein 1569509 933139 spr1589 Streptococcus pneumoniae R6 iojap-related protein NP_359181.1 1569156 R 171101 CDS NP_359182.1 15903632 933302 complement(1569522..1570022) 1 NC_003098.1 Similar to isochorismatase; isochorismatase 1570022 933302 spr1590 Streptococcus pneumoniae R6 isochorismatase NP_359182.1 1569522 R 171101 CDS NP_359183.1 15903633 933060 complement(1570023..1570616) 1 NC_003098.1 hypothetical protein 1570616 933060 spr1591 Streptococcus pneumoniae R6 hypothetical protein NP_359183.1 1570023 R 171101 CDS NP_359184.1 15903634 933444 complement(1570616..1571245) 1 NC_003098.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 1571245 nadD 933444 nadD Streptococcus pneumoniae R6 nicotinic acid mononucleotide adenylyltransferase NP_359184.1 1570616 R 171101 CDS NP_359185.1 15903635 933137 complement(1571297..1571608) 1 NC_003098.1 hypothetical protein 1571608 933137 spr1593 Streptococcus pneumoniae R6 hypothetical protein NP_359185.1 1571297 R 171101 CDS NP_359186.1 15903636 933397 complement(1571823..1572929) 1 NC_003098.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH 1572929 933397 spr1594 Streptococcus pneumoniae R6 GTP-binding protein YqeH NP_359186.1 1571823 R 171101 CDS NP_359187.1 15903637 933109 complement(1572932..1573522) 1 NC_003098.1 hypothetical protein 1573522 933109 spr1595 Streptococcus pneumoniae R6 hypothetical protein NP_359187.1 1572932 R 171101 CDS NP_359188.1 15903638 933228 complement(1573474..1574370) 1 NC_003098.1 magnesium and cobalt transporter CorA 1574370 corA 933228 corA Streptococcus pneumoniae R6 magnesium and cobalt transporter CorA NP_359188.1 1573474 R 171101 CDS NP_359189.1 15903639 933438 complement(1574427..1575032) 1 NC_003098.1 hypothetical protein 1575032 933438 spr1597 Streptococcus pneumoniae R6 hypothetical protein NP_359189.1 1574427 R 171101 CDS NP_359190.1 15903640 933071 1575376..1576335 1 NC_003098.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 1576335 dctA 933071 dctA Streptococcus pneumoniae R6 serine/threonine transporter SstT NP_359190.1 1575376 D 171101 CDS NP_359191.1 15903641 933402 1576403..1577356 1 NC_003098.1 hypothetical protein 1577356 933402 spr1599 Streptococcus pneumoniae R6 hypothetical protein NP_359191.1 1576403 D 171101 CDS NP_359192.1 15903642 933307 1577455..1577880 1 NC_003098.1 Probable transcription regulator; transcriptional regulator 1577880 933307 spr1600 Streptococcus pneumoniae R6 transcriptional regulator NP_359192.1 1577455 D 171101 CDS NP_359193.1 15903643 933432 1577898..1578200 1 NC_003098.1 hypothetical protein 1578200 933432 spr1601 Streptococcus pneumoniae R6 hypothetical protein NP_359193.1 1577898 D 171101 CDS NP_359194.1 15903644 933436 1578217..1578531 1 NC_003098.1 thioredoxin 1578531 trxA 933436 trxA Streptococcus pneumoniae R6 thioredoxin NP_359194.1 1578217 D 171101 CDS NP_359195.1 15903645 933864 1578797..1579369 1 NC_003098.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 1579369 933864 spr1603 Streptococcus pneumoniae R6 7-cyano-7-deazaguanine reductase NP_359195.1 1578797 D 171101 CDS YP_008719805.1 555247351 17374510 1579381..1579824 1 NC_003098.1 hypothetical protein 1579824 17374510 spr1603a Streptococcus pneumoniae R6 hypothetical protein YP_008719805.1 1579381 D 171101 CDS NP_359196.1 15903646 933893 complement(1579849..1580517) 1 NC_003098.1 aquaporin 1580517 aqpZ 933893 aqpZ Streptococcus pneumoniae R6 aquaporin NP_359196.1 1579849 R 171101 CDS NP_359197.1 15903647 934041 complement(1580628..1581188) 1 NC_003098.1 hypothetical protein 1581188 934041 spr1605 Streptococcus pneumoniae R6 hypothetical protein NP_359197.1 1580628 R 171101 CDS NP_359198.1 15903648 933318 complement(1581428..1583224) 1 NC_003098.1 oligoendopeptidase F 1583224 pepF 933318 pepF Streptococcus pneumoniae R6 oligoendopeptidase F NP_359198.1 1581428 R 171101 CDS NP_359199.1 15903649 933160 complement(1583235..1583990) 1 NC_003098.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 1583990 933160 spr1607 Streptococcus pneumoniae R6 16S ribosomal RNA methyltransferase RsmE NP_359199.1 1583235 R 171101 CDS NP_359200.2 161410740 934029 complement(1583980..1584930) 1 NC_003098.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 1584930 prmA 934029 prmA Streptococcus pneumoniae R6 ribosomal protein L11 methyltransferase NP_359200.2 1583980 R 171101 CDS NP_359201.1 15903651 933359 complement(1585068..1585496) 1 NC_003098.1 MutT/nudix family protein 1585496 mutT 933359 mutT Streptococcus pneumoniae R6 MutT/nudix family protein NP_359201.1 1585068 R 171101 CDS NP_359202.1 15903652 933498 complement(1585462..1586580) 1 NC_003098.1 hypothetical protein 1586580 933498 spr1610 Streptococcus pneumoniae R6 hypothetical protein NP_359202.1 1585462 R 171101 CDS NP_359203.1 15903653 933786 complement(1586584..1587054) 1 NC_003098.1 hypothetical protein 1587054 933786 spr1611 Streptococcus pneumoniae R6 hypothetical protein NP_359203.1 1586584 R 171101 CDS NP_359204.1 15903654 933845 complement(1587345..1587797) 1 NC_003098.1 hypothetical protein 1587797 933845 spr1612 Streptococcus pneumoniae R6 hypothetical protein NP_359204.1 1587345 R 171101 CDS NP_359205.1 15903655 933465 complement(1587834..1588040) 1 NC_003098.1 hypothetical protein 1588040 933465 spr1613 Streptococcus pneumoniae R6 hypothetical protein NP_359205.1 1587834 R 171101 CDS NP_359206.1 15903656 933308 complement(1588150..1588329) 1 NC_003098.1 hypothetical protein 1588329 933308 spr1614 Streptococcus pneumoniae R6 hypothetical protein NP_359206.1 1588150 R 171101 CDS NP_359207.1 15903657 933744 complement(1588494..1588733) 1 NC_003098.1 hypothetical protein 1588733 933744 spr1615 Streptococcus pneumoniae R6 hypothetical protein NP_359207.1 1588494 R 171101 CDS NP_359208.1 15903658 933195 1589003..1590274 1 NC_003098.1 recombination factor protein RarA 1590274 cshA 933195 cshA Streptococcus pneumoniae R6 recombination factor protein RarA NP_359208.1 1589003 D 171101 CDS NP_359209.1 15903659 933211 complement(1590821..1592140) 1 NC_003098.1 sucrose-6-phosphate hydrolase 1592140 sacA 933211 sacA Streptococcus pneumoniae R6 sucrose-6-phosphate hydrolase NP_359209.1 1590821 R 171101 CDS NP_359210.1 15903660 933483 complement(1592150..1593004) 1 NC_003098.1 sugar ABC transporter permease 1593004 ABC-MSP 933483 ABC-MSP Streptococcus pneumoniae R6 sugar ABC transporter permease NP_359210.1 1592150 R 171101 CDS NP_359211.1 15903661 932933 complement(1592997..1593905) 1 NC_003098.1 sugar ABC transporter permease 1593905 ABC-MSP 932933 ABC-MSP Streptococcus pneumoniae R6 sugar ABC transporter permease NP_359211.1 1592997 R 171101 CDS NP_359212.1 15903662 933745 complement(1593995..1595308) 1 NC_003098.1 sugar ABC transporter substrate-binding protein 1595308 ABC-SBP 933745 ABC-SBP Streptococcus pneumoniae R6 sugar ABC transporter substrate-binding protein NP_359212.1 1593995 R 171101 CDS NP_359213.1 15903663 933960 complement(1595432..1596445) 1 NC_003098.1 sucrose operon repressor 1596445 scrR 933960 scrR Streptococcus pneumoniae R6 sucrose operon repressor NP_359213.1 1595432 R 171101 CDS NP_359214.1 15903664 933678 complement(1596789..1598327) 1 NC_003098.1 regulator protein; hypothetical protein 1598327 933678 spr1622 Streptococcus pneumoniae R6 hypothetical protein NP_359214.1 1596789 R 171101 CDS NP_359215.1 15903665 932829 1598954..1599526 1 NC_003098.1 hypothetical protein 1599526 932829 spr1623 Streptococcus pneumoniae R6 hypothetical protein NP_359215.1 1598954 D 171101 CDS NP_359216.1 15903666 933828 1599538..1599708 1 NC_003098.1 hypothetical protein 1599708 933828 spr1624 Streptococcus pneumoniae R6 hypothetical protein NP_359216.1 1599538 D 171101 CDS NP_359217.1 15903667 933793 1599747..1600355 1 NC_003098.1 general stress protein 24 1600355 933793 spr1625 Streptococcus pneumoniae R6 general stress protein 24 NP_359217.1 1599747 D 171101 CDS NP_359218.1 15903668 933216 1600386..1600589 1 NC_003098.1 hypothetical protein 1600589 933216 spr1626 Streptococcus pneumoniae R6 hypothetical protein NP_359218.1 1600386 D 171101 CDS NP_359219.1 15903669 933262 complement(1601116..1601562) 1 NC_003098.1 Probable acetyltransferase; hypothetical protein 1601562 933262 spr1627 Streptococcus pneumoniae R6 hypothetical protein NP_359219.1 1601116 R 171101 CDS NP_359220.1 15903670 933620 1601632..1602291 1 NC_003098.1 type IV prepilin peptidase 1602291 pilD 933620 pilD Streptococcus pneumoniae R6 type IV prepilin peptidase NP_359220.1 1601632 D 171101 CDS NP_359221.1 15903671 933063 complement(1602343..1603494) 1 NC_003098.1 DNA-binding protein; transcriptional regulator 1603494 933063 spr1629 Streptococcus pneumoniae R6 transcriptional regulator NP_359221.1 1602343 R 171101 CDS NP_359222.1 15903672 933473 complement(1603509..1604240) 1 NC_003098.1 hypothetical protein 1604240 933473 spr1630 Streptococcus pneumoniae R6 hypothetical protein NP_359222.1 1603509 R 171101 CDS NP_359223.1 15903673 933255 complement(1604542..1605318) 1 NC_003098.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1605318 trpA 933255 trpA Streptococcus pneumoniae R6 tryptophan synthase subunit alpha NP_359223.1 1604542 R 171101 CDS NP_359224.1 15903674 933618 complement(1605311..1606534) 1 NC_003098.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1606534 trpB 933618 trpB Streptococcus pneumoniae R6 tryptophan synthase subunit beta NP_359224.1 1605311 R 171101 CDS NP_359225.1 15903675 933859 complement(1606512..1607141) 1 NC_003098.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase 1607141 trpF 933859 trpF Streptococcus pneumoniae R6 N-(5'-phosphoribosyl)anthranilate isomerase NP_359225.1 1606512 R 171101 CDS NP_359226.1 15903676 933756 complement(1607098..1607865) 1 NC_003098.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol phosphate synthase 1607865 trpC 933756 trpC Streptococcus pneumoniae R6 indole-3-glycerol phosphate synthase NP_359226.1 1607098 R 171101 CDS NP_359227.1 15903677 933836 complement(1607862..1608866) 1 NC_003098.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1608866 trpD 933836 trpD Streptococcus pneumoniae R6 anthranilate phosphoribosyltransferase NP_359227.1 1607862 R 171101 CDS NP_359228.1 15903678 933813 complement(1608877..1609443) 1 NC_003098.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1609443 trpG 933813 trpG Streptococcus pneumoniae R6 anthranilate synthase component II NP_359228.1 1608877 R 171101 CDS NP_359229.2 229000970 933781 complement(1609440..1610801) 1 NC_003098.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1610801 trpE 933781 trpE Streptococcus pneumoniae R6 anthranilate synthase component I NP_359229.2 1609440 R 171101 CDS NP_359231.1 15903681 933352 complement(1611988..1612989) 1 NC_003098.1 catabolite control protein 1612989 ccpA 933352 ccpA Streptococcus pneumoniae R6 catabolite control protein NP_359231.1 1611988 R 171101 CDS NP_359232.1 15903682 933345 complement(1613097..1613465) 1 NC_003098.1 hypothetical protein 1613465 933345 spr1640 Streptococcus pneumoniae R6 hypothetical protein NP_359232.1 1613097 R 171101 CDS NP_359233.1 15903683 933023 complement(1613561..1614271) 1 NC_003098.1 Mg2+ transporter 1614271 mgtC 933023 mgtC Streptococcus pneumoniae R6 Mg2+ transporter NP_359233.1 1613561 R 171101 CDS NP_359235.1 15903685 933624 complement(1614274..1615965) 1 NC_003098.1 ABC transporter permease 1615965 ABC-MSP 933624 ABC-MSP Streptococcus pneumoniae R6 ABC transporter permease NP_359235.1 1614274 R 171101 CDS NP_359236.1 15903686 933848 complement(1615977..1616987) 1 NC_003098.1 ABC transporter ATP-binding protein 1616987 ABC-NBD 933848 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_359236.1 1615977 R 171101 CDS NP_359237.1 15903687 933166 complement(1617090..1618157) 1 NC_003098.1 ABC transporter substrate-binding protein 1618157 ABC-SBP 933166 ABC-SBP Streptococcus pneumoniae R6 ABC transporter substrate-binding protein NP_359237.1 1617090 R 171101 CDS NP_359238.1 15903688 933543 complement(1618182..1618841) 1 NC_003098.1 hypothetical protein 1618841 933543 spr1646 Streptococcus pneumoniae R6 hypothetical protein NP_359238.1 1618182 R 171101 CDS NP_359239.1 15903689 933268 complement(1619051..1620031) 1 NC_003098.1 UDP-glucose 4-epimerase 1620031 galE 933268 galE Streptococcus pneumoniae R6 UDP-glucose 4-epimerase NP_359239.1 1619051 R 171101 CDS NP_359240.1 15903690 932967 complement(1620044..1621519) 1 NC_003098.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase 1621519 galT 932967 galT Streptococcus pneumoniae R6 galactose-1-phosphate uridylyltransferase NP_359240.1 1620044 R 171101 CDS NP_359241.1 15903691 933690 complement(1621532..1622173) 1 NC_003098.1 transcriptional regulator (phoU like); phosphate transporter PhoU 1622173 933690 spr1649 Streptococcus pneumoniae R6 phosphate transporter PhoU NP_359241.1 1621532 R 171101 CDS NP_359244.1 15903694 933108 complement(1623066..1625225) 1 NC_003098.1 cell wall surface anchor family protein 1625225 933108 spr1652 Streptococcus pneumoniae R6 cell wall surface anchor family protein NP_359244.1 1623066 R 171101 CDS NP_359246.1 15903696 933440 complement(1626356..1627609) 1 NC_003098.1 role in biosynthesis of amino sugar; capsular polysaccharide biosynthesis protein 1627609 933440 spr1654 Streptococcus pneumoniae R6 capsular polysaccharide biosynthesis protein NP_359246.1 1626356 R 171101 CDS NP_359247.1 15903697 932855 complement(1627625..1628356) 1 NC_003098.1 glycosyltransferase; glycosyl transferase 1628356 932855 spr1655 Streptococcus pneumoniae R6 glycosyl transferase NP_359247.1 1627625 R 171101 CDS NP_359248.1 15903698 934027 complement(1628490..1630241) 1 NC_003098.1 ABC transporter ATP-binding protein/permease 1630241 ABC-N/P 934027 ABC-N/P Streptococcus pneumoniae R6 ABC transporter ATP-binding protein/permease NP_359248.1 1628490 R 171101 CDS NP_359249.1 15903699 934046 complement(1630231..1632015) 1 NC_003098.1 ABC transporter ATP-binding protein/permease 1632015 ABC-N/P 934046 ABC-N/P Streptococcus pneumoniae R6 ABC transporter ATP-binding protein/permease NP_359249.1 1630231 R 171101 CDS NP_359252.1 15903702 933227 1633221..1634048 1 NC_003098.1 exodeoxyribonuclease 1634048 exoA 933227 exoA Streptococcus pneumoniae R6 exodeoxyribonuclease NP_359252.1 1633221 D 171101 CDS NP_359253.1 15903703 933082 1634203..1634442 1 NC_003098.1 hypothetical protein 1634442 933082 spr1661 Streptococcus pneumoniae R6 hypothetical protein NP_359253.1 1634203 D 171101 CDS NP_359254.1 15903704 934026 1635320..1635901 1 NC_003098.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 1635901 xpt 934026 xpt Streptococcus pneumoniae R6 xanthine phosphoribosyltransferase NP_359254.1 1635320 D 171101 CDS NP_359255.1 15903705 933092 1635901..1637163 1 NC_003098.1 xanthine permease 1637163 pbuX 933092 pbuX Streptococcus pneumoniae R6 xanthine permease NP_359255.1 1635901 D 171101 CDS NP_359256.1 15903706 933798 complement(1637214..1637675) 1 NC_003098.1 hypothetical protein 1637675 dpnD 933798 dpnD Streptococcus pneumoniae R6 hypothetical protein NP_359256.1 1637214 R 171101 CDS NP_359257.1 15903707 933882 complement(1637672..1638436) 1 NC_003098.1 type II restriction enzyme DpnI (dpnC) 1638436 dpnC 933882 dpnC Streptococcus pneumoniae R6 type II restriction enzyme DpnI (dpnC) NP_359257.1 1637672 R 171101 CDS NP_359258.1 15903708 933648 complement(1638617..1639042) 1 NC_003098.1 Similar to E. coli PaaI protein involved in phenylacetic acid degradation; hypothetical protein 1639042 933648 spr1666 Streptococcus pneumoniae R6 hypothetical protein NP_359258.1 1638617 R 171101 CDS NP_359259.1 15903709 933029 complement(1639091..1640572) 1 NC_003098.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase 1640572 galT 933029 galT Streptococcus pneumoniae R6 galactose-1-phosphate uridylyltransferase NP_359259.1 1639091 R 171101 CDS NP_359260.1 15903710 933086 complement(1640591..1641769) 1 NC_003098.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 1641769 galK 933086 galK Streptococcus pneumoniae R6 galactokinase NP_359260.1 1640591 R 171101 CDS NP_359261.1 15903711 934048 1641933..1642940 1 NC_003098.1 regulator of gal operon GalR 1642940 galR 934048 galR Streptococcus pneumoniae R6 regulator of gal operon GalR NP_359261.1 1641933 D 171101 CDS NP_359262.1 15903712 933078 complement(1642986..1644023) 1 NC_003098.1 zinc-containing alcohol dehydrogenase 1644023 adhB 933078 adhB Streptococcus pneumoniae R6 zinc-containing alcohol dehydrogenase NP_359262.1 1642986 R 171101 CDS NP_359263.1 15903713 932950 complement(1644024..1644377) 1 NC_003098.1 Similar to transcriptional regulator (MerR family); hypothetical protein 1644377 932950 spr1671 Streptococcus pneumoniae R6 hypothetical protein NP_359263.1 1644024 R 171101 CDS NP_359264.1 15903714 933821 complement(1644621..1645520) 1 NC_003098.1 cation efflux system protein 1645520 czcD 933821 czcD Streptococcus pneumoniae R6 cation efflux system protein NP_359264.1 1644621 R 171101 CDS NP_359265.1 15903715 933091 1645644..1646180 1 NC_003098.1 tetR-family transcriptional regulator; hypothetical protein 1646180 933091 spr1673 Streptococcus pneumoniae R6 hypothetical protein NP_359265.1 1645644 D 171101 CDS NP_359266.1 15903716 933875 complement(1646347..1647156) 1 NC_003098.1 hypothetical protein 1647156 933875 spr1674 Streptococcus pneumoniae R6 hypothetical protein NP_359266.1 1646347 R 171101 CDS NP_359267.1 15903717 933126 1647556..1648074 1 NC_003098.1 transposase 1648074 IS1167 933126 IS1167 Streptococcus pneumoniae R6 transposase NP_359267.1 1647556 D 171101 CDS NP_359269.1 15903719 933005 complement(1648982..1650502) 1 NC_003098.1 choline ABC transporter permease 1650502 proWX 933005 proWX Streptococcus pneumoniae R6 choline ABC transporter permease NP_359269.1 1648982 R 171101 CDS NP_359270.1 15903720 933246 complement(1650495..1651223) 1 NC_003098.1 choline transporter 1651223 proV 933246 proV Streptococcus pneumoniae R6 choline transporter NP_359270.1 1650495 R 171101 CDS NP_359271.1 15903721 933998 complement(1651238..1652002) 1 NC_003098.1 hypothetical protein 1652002 933998 spr1679 Streptococcus pneumoniae R6 hypothetical protein NP_359271.1 1651238 R 171101 CDS NP_359272.1 15903722 934024 complement(1652006..1652449) 1 NC_003098.1 transcriptional regulator; hypothetical protein 1652449 934024 spr1680 Streptococcus pneumoniae R6 hypothetical protein NP_359272.1 1652006 R 171101 CDS NP_359273.1 15903723 932956 complement(1653131..1653436) 1 NC_003098.1 hypothetical protein 1653436 932956 spr1681 Streptococcus pneumoniae R6 hypothetical protein NP_359273.1 1653131 R 171101 CDS NP_359274.1 15903724 932959 complement(1653449..1654513) 1 NC_003098.1 glutamyl aminopeptidase 1654513 pepA 932959 pepA Streptococcus pneumoniae R6 glutamyl aminopeptidase NP_359274.1 1653449 R 171101 CDS NP_359275.1 15903725 933099 1654914..1655615 1 NC_003098.1 NAD-dependent epimerase/dehydratase 1655615 933099 spr1683 Streptococcus pneumoniae R6 NAD-dependent epimerase/dehydratase NP_359275.1 1654914 D 171101 CDS NP_359276.1 15903726 933870 1656023..1656997 1 NC_003098.1 iron-compound ABC transporter permease 1656997 fatD 933870 fatD Streptococcus pneumoniae R6 iron-compound ABC transporter permease NP_359276.1 1656023 D 171101 CDS NP_359277.1 15903727 932929 1656987..1657943 1 NC_003098.1 iron-compound ABC transporter permease 1657943 fatC 932929 fatC Streptococcus pneumoniae R6 iron-compound ABC transporter permease NP_359277.1 1656987 D 171101 CDS NP_359278.1 15903728 933979 1657940..1658692 1 NC_003098.1 iron-compound ABC transporter ATP-binding protein 1658692 fecE 933979 fecE Streptococcus pneumoniae R6 iron-compound ABC transporter ATP-binding protein NP_359278.1 1657940 D 171101 CDS NP_359279.1 15903729 933306 1658788..1659753 1 NC_003098.1 iron-compound ABC transporter substrate-binding protein 1659753 fatB 933306 fatB Streptococcus pneumoniae R6 iron-compound ABC transporter substrate-binding protein NP_359279.1 1658788 D 171101 CDS NP_359280.1 15903730 933934 complement(1659978..1660220) 1 NC_003098.1 hypothetical protein 1660220 933934 spr1688 Streptococcus pneumoniae R6 hypothetical protein NP_359280.1 1659978 R 171101 CDS NP_359281.1 15903731 933891 complement(1660220..1660942) 1 NC_003098.1 ribosomal large subunit pseudouridine synthase B 1660942 rluB 933891 rluB Streptococcus pneumoniae R6 ribosomal large subunit pseudouridine synthase B NP_359281.1 1660220 R 171101 CDS NP_359282.1 15903732 933665 complement(1660929..1661498) 1 NC_003098.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B 1661498 scpB 933665 scpB Streptococcus pneumoniae R6 segregation and condensation protein B NP_359282.1 1660929 R 171101 CDS NP_359283.1 15903733 933770 complement(1661517..1662245) 1 NC_003098.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A 1662245 scpA 933770 scpA Streptococcus pneumoniae R6 segregation and condensation protein A NP_359283.1 1661517 R 171101 CDS NP_359284.1 15903734 932943 complement(1662245..1662985) 1 NC_003098.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD-like protein 1662985 xerD 932943 xerD Streptococcus pneumoniae R6 site-specific tyrosine recombinase XerD-like protein NP_359284.1 1662245 R 171101 CDS NP_359285.1 15903735 933937 complement(1662976..1663437) 1 NC_003098.1 hypothetical protein 1663437 933937 spr1693 Streptococcus pneumoniae R6 hypothetical protein NP_359285.1 1662976 R 171101 CDS NP_359286.1 15903736 932835 complement(1663434..1663955) 1 NC_003098.1 hypothetical protein 1663955 932835 spr1694 Streptococcus pneumoniae R6 hypothetical protein NP_359286.1 1663434 R 171101 CDS NP_359287.2 161410739 933028 complement(1663931..1664902) 1 NC_003098.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; fused deoxyribonucleotide triphosphate pyrophosphatase/hypothetical protein 1664902 933028 spr1695 Streptococcus pneumoniae R6 fused deoxyribonucleotide triphosphate pyrophosphatase/hypothetical protein NP_359287.2 1663931 R 171101 CDS NP_359288.1 15903738 933741 complement(1664899..1665693) 1 NC_003098.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1665693 murI 933741 murI Streptococcus pneumoniae R6 glutamate racemase NP_359288.1 1664899 R 171101 CDS NP_359289.1 15903739 933041 complement(1665900..1666202) 1 NC_003098.1 hypothetical protein 1666202 933041 spr1697 Streptococcus pneumoniae R6 hypothetical protein NP_359289.1 1665900 R 171101 CDS NP_359290.1 15903740 933881 complement(1666290..1667915) 1 NC_003098.1 Also highly similar to trehalose-6-phosphate hydrolase; dextran glucosidase 1667915 dexS 933881 dexS Streptococcus pneumoniae R6 dextran glucosidase NP_359290.1 1666290 R 171101 CDS NP_359291.1 15903741 933714 complement(1668093..1670210) 1 NC_003098.1 PTS system trehalose-specific transporter subunit IIBC 1670210 treP 933714 treP Streptococcus pneumoniae R6 PTS system trehalose-specific transporter subunit IIBC NP_359291.1 1668093 R 171101 CDS NP_359292.1 15903742 933116 1670245..1670955 1 NC_003098.1 trehalose operon transcriptional repressor 1670955 treR 933116 treR Streptococcus pneumoniae R6 trehalose operon transcriptional repressor NP_359292.1 1670245 D 171101 CDS NP_359295.1 15903745 932969 complement(1672492..1673463) 1 NC_003098.1 oligopeptide ABC transporter ATP-binding protein AmiF 1673463 amiF 932969 amiF Streptococcus pneumoniae R6 oligopeptide ABC transporter ATP-binding protein AmiF NP_359295.1 1672492 R 171101 CDS NP_359296.1 15903746 934004 complement(1673429..1674496) 1 NC_003098.1 oligopeptide ABC transporter ATP-binding protein AmiE 1674496 amiE 934004 amiE Streptococcus pneumoniae R6 oligopeptide ABC transporter ATP-binding protein AmiE NP_359296.1 1673429 R 171101 CDS NP_359297.1 15903747 932913 complement(1674505..1675431) 1 NC_003098.1 oligopeptide ABC transporter permease AmiD 1675431 amiD 932913 amiD Streptococcus pneumoniae R6 oligopeptide ABC transporter permease AmiD NP_359297.1 1674505 R 171101 CDS NP_359298.1 15903748 933016 complement(1675431..1676927) 1 NC_003098.1 oligopeptide ABC transporter permease AmiC 1676927 amiC 933016 amiC Streptococcus pneumoniae R6 oligopeptide ABC transporter permease AmiC NP_359298.1 1675431 R 171101 CDS NP_359299.1 15903749 933861 complement(1676994..1678973) 1 NC_003098.1 oligopeptide ABC transporter substrate-binding protein 1678973 amiA 933861 amiA Streptococcus pneumoniae R6 oligopeptide ABC transporter substrate-binding protein NP_359299.1 1676994 R 171101 CDS NP_359300.1 15903750 932951 complement(1679660..1680853) 1 NC_003098.1 hypothetical protein 1680853 932951 spr1708 Streptococcus pneumoniae R6 hypothetical protein NP_359300.1 1679660 R 171101 CDS NP_359301.1 15903751 933971 complement(1680991..1682433) 1 NC_003098.1 sucrose phosphorylase 1682433 gtfA 933971 gtfA Streptococcus pneumoniae R6 sucrose phosphorylase NP_359301.1 1680991 R 171101 CDS YP_008719806.1 555247352 17374511 complement(1682617..1682784) 1 NC_003098.1 hypothetical protein 1682784 17374511 spr1709a Streptococcus pneumoniae R6 hypothetical protein YP_008719806.1 1682617 R 171101 CDS NP_359302.1 15903752 933978 complement(1682791..1683624) 1 NC_003098.1 sugar ABC transporter permease 1683624 msmG 933978 msmG Streptococcus pneumoniae R6 sugar ABC transporter permease NP_359302.1 1682791 R 171101 CDS NP_359303.1 15903753 933920 complement(1683638..1684528) 1 NC_003098.1 sugar ABC transporter permease 1684528 msmF 933920 msmF Streptococcus pneumoniae R6 sugar ABC transporter permease NP_359303.1 1683638 R 171101 CDS NP_359304.1 15903754 933919 complement(1684518..1685777) 1 NC_003098.1 sugar ABC transporter substrate-binding protein 1685777 msmE 933919 msmE Streptococcus pneumoniae R6 sugar ABC transporter substrate-binding protein NP_359304.1 1684518 R 171101 CDS NP_359305.1 15903755 933461 complement(1685869..1688031) 1 NC_003098.1 alpha-galactosidase 1688031 aga 933461 aga Streptococcus pneumoniae R6 alpha-galactosidase NP_359305.1 1685869 R 171101 CDS NP_359306.1 15903756 932882 1688139..1688999 1 NC_003098.1 MSM (multiple sugar metabolism) operon regulatory protein 1688999 msmR 932882 msmR Streptococcus pneumoniae R6 MSM (multiple sugar metabolism) operon regulatory protein NP_359306.1 1688139 D 171101 CDS NP_359307.1 15903757 933753 1688996..1689931 1 NC_003098.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1689931 birA 933753 birA Streptococcus pneumoniae R6 biotin--protein ligase NP_359307.1 1688996 D 171101 CDS NP_359309.1 15903759 933414 complement(1697564..1698919) 1 NC_003098.1 Similar to RNA methyltransferase; hypothetical protein 1698919 933414 spr1717 Streptococcus pneumoniae R6 hypothetical protein NP_359309.1 1697564 R 171101 CDS NP_359310.2 161410738 933158 1698957..1699733 1 NC_003098.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1699733 recX 933158 recX Streptococcus pneumoniae R6 recombination regulator RecX NP_359310.2 1698957 D 171101 CDS NP_359311.1 15903761 933375 1699822..1700355 1 NC_003098.1 hypothetical protein 1700355 933375 spr1719 Streptococcus pneumoniae R6 hypothetical protein NP_359311.1 1699822 D 171101 CDS NP_359312.1 15903762 933040 complement(1700709..1700915) 1 NC_003098.1 hypothetical protein 1700915 933040 spr1720 Streptococcus pneumoniae R6 hypothetical protein NP_359312.1 1700709 R 171101 CDS NP_359313.1 15903763 933774 1701075..1702304 1 NC_003098.1 transposase 1702304 933774 spr1721 Streptococcus pneumoniae R6 transposase NP_359313.1 1701075 D 171101 CDS NP_359314.1 15903764 932997 complement(1702403..1704025) 1 NC_003098.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 1704025 groEL 932997 groEL Streptococcus pneumoniae R6 molecular chaperone GroEL NP_359314.1 1702403 R 171101 CDS NP_359315.1 15903765 933334 complement(1704041..1704325) 1 NC_003098.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1704325 groES 933334 groES Streptococcus pneumoniae R6 co-chaperonin GroES NP_359315.1 1704041 R 171101 CDS NP_359316.1 15903766 933820 complement(1704481..1704876) 1 NC_003098.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1704876 ssbB 933820 ssbB Streptococcus pneumoniae R6 single-stranded DNA-binding protein NP_359316.1 1704481 R 171101 CDS NP_359317.1 15903767 933630 complement(1704954..1705715) 1 NC_003098.1 oxidoreductase 1705715 ydfG 933630 ydfG Streptococcus pneumoniae R6 oxidoreductase NP_359317.1 1704954 R 171101 CDS NP_359318.1 15903768 933705 complement(1705748..1706374) 1 NC_003098.1 hypothetical protein 1706374 933705 spr1726 Streptococcus pneumoniae R6 hypothetical protein NP_359318.1 1705748 R 171101 CDS NP_359319.1 15903769 933577 complement(1706390..1706707) 1 NC_003098.1 Similar to thioredoxin H1; hypothetical protein 1706707 933577 spr1727 Streptococcus pneumoniae R6 hypothetical protein NP_359319.1 1706390 R 171101 CDS NP_359320.1 15903770 932863 complement(1706704..1707003) 1 NC_003098.1 hypothetical protein 1707003 932863 spr1728 Streptococcus pneumoniae R6 hypothetical protein NP_359320.1 1706704 R 171101 CDS NP_359322.1 15903772 933706 complement(1707692..1708366) 1 NC_003098.1 hypothetical protein 1708366 933706 spr1730 Streptococcus pneumoniae R6 hypothetical protein NP_359322.1 1707692 R 171101 CDS NP_359323.1 15903773 933697 complement(1708372..1708821) 1 NC_003098.1 hypothetical protein 1708821 933697 spr1731 Streptococcus pneumoniae R6 hypothetical protein NP_359323.1 1708372 R 171101 CDS NP_359324.1 15903774 933704 complement(1708932..1709435) 1 NC_003098.1 Similar to bacteriocin transport permease; PAP2 family protein 1709435 933704 spr1732 Streptococcus pneumoniae R6 PAP2 family protein NP_359324.1 1708932 R 171101 CDS NP_359325.1 15903775 933703 complement(1709432..1709794) 1 NC_003098.1 hypothetical protein 1709794 933703 spr1733 Streptococcus pneumoniae R6 hypothetical protein NP_359325.1 1709432 R 171101 CDS NP_359326.1 15903776 933695 complement(1709860..1710891) 1 NC_003098.1 ABC transporter ATP-binding protein 1710891 933695 spr1734 Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_359326.1 1709860 R 171101 CDS NP_359330.1 15903780 933696 complement(1712329..1713045) 1 NC_003098.1 hypothetical protein 1713045 933696 spr1738 Streptococcus pneumoniae R6 hypothetical protein NP_359330.1 1712329 R 171101 CDS NP_359331.1 15903781 933687 complement(1713926..1715341) 1 NC_003098.1 pneumolysin 1715341 ply 933687 ply Streptococcus pneumoniae R6 pneumolysin NP_359331.1 1713926 R 171101 CDS NP_359332.1 15903782 933693 complement(1715352..1715762) 1 NC_003098.1 hypothetical protein 1715762 933693 spr1740 Streptococcus pneumoniae R6 hypothetical protein NP_359332.1 1715352 R 171101 CDS NP_359333.1 15903783 933692 complement(1715755..1716363) 1 NC_003098.1 hypothetical protein 1716363 933692 spr1741 Streptococcus pneumoniae R6 hypothetical protein NP_359333.1 1715755 R 171101 CDS NP_359338.1 15903788 933685 complement(1718122..1718382) 1 NC_003098.1 hypothetical protein 1718382 933685 spr1746 Streptococcus pneumoniae R6 hypothetical protein NP_359338.1 1718122 R 171101 CDS NP_359339.1 15903789 933683 complement(1718441..1718995) 1 NC_003098.1 hypothetical protein 1718995 933683 spr1747 Streptococcus pneumoniae R6 hypothetical protein NP_359339.1 1718441 R 171101 CDS NP_359340.1 15903790 933682 complement(1718982..1719179) 1 NC_003098.1 hypothetical protein 1719179 933682 spr1748 Streptococcus pneumoniae R6 hypothetical protein NP_359340.1 1718982 R 171101 CDS NP_359341.1 15903791 933674 complement(1719183..1719977) 1 NC_003098.1 hypothetical protein 1719977 933674 spr1749 Streptococcus pneumoniae R6 hypothetical protein NP_359341.1 1719183 R 171101 CDS NP_359343.1 15903793 933677 complement(1720939..1721298) 1 NC_003098.1 hypothetical protein 1721298 933677 spr1751 Streptococcus pneumoniae R6 hypothetical protein NP_359343.1 1720939 R 171101 CDS NP_359344.1 15903794 933671 complement(1721344..1721586) 1 NC_003098.1 hypothetical protein 1721586 933671 spr1752 Streptococcus pneumoniae R6 hypothetical protein NP_359344.1 1721344 R 171101 CDS NP_359345.1 15903795 933676 complement(1721537..1721710) 1 NC_003098.1 hypothetical protein 1721710 933676 spr1753 Streptococcus pneumoniae R6 hypothetical protein NP_359345.1 1721537 R 171101 CDS NP_359346.1 15903796 933669 complement(1722069..1723025) 1 NC_003098.1 N-acetylmuramoyl-L-alanine amidase 1723025 lytA 933669 lytA Streptococcus pneumoniae R6 N-acetylmuramoyl-L-alanine amidase NP_359346.1 1722069 R 171101 CDS NP_359348.1 15903798 933672 complement(1723401..1724771) 1 NC_003098.1 MATE efflux family protein DinF 1724771 dinF 933672 dinF Streptococcus pneumoniae R6 MATE efflux family protein DinF NP_359348.1 1723401 R 171101 CDS NP_359349.1 15903799 933670 complement(1725078..1726244) 1 NC_003098.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1726244 recA 933670 recA Streptococcus pneumoniae R6 recombinase A NP_359349.1 1725078 R 171101 CDS NP_359350.1 15903800 933663 complement(1726299..1727555) 1 NC_003098.1 Competence induced protein A; competence damage-inducible protein A 1727555 cinA 933663 cinA Streptococcus pneumoniae R6 competence damage-inducible protein A NP_359350.1 1726299 R 171101 CDS NP_359351.1 15903801 933667 complement(1727640..1728656) 1 NC_003098.1 transcriptional regulator 1728656 lytR 933667 lytR Streptococcus pneumoniae R6 transcriptional regulator NP_359351.1 1727640 R 171101 CDS NP_359352.1 15903802 933666 complement(1728664..1729182) 1 NC_003098.1 hypothetical protein 1729182 933666 spr1760 Streptococcus pneumoniae R6 hypothetical protein NP_359352.1 1728664 R 171101 CDS NP_359353.1 15903803 933660 complement(1729172..1729615) 1 NC_003098.1 hypothetical protein 1729615 933660 spr1761 Streptococcus pneumoniae R6 hypothetical protein NP_359353.1 1729172 R 171101 CDS NP_359354.1 15903804 933664 complement(1729701..1730321) 1 NC_003098.1 hypothetical protein 1730321 933664 spr1762 Streptococcus pneumoniae R6 hypothetical protein NP_359354.1 1729701 R 171101 CDS NP_359355.1 15903805 933657 complement(1730704..1731567) 1 NC_003098.1 transcriptional activator 1731567 plcR 933657 plcR Streptococcus pneumoniae R6 transcriptional activator NP_359355.1 1730704 R 171101 CDS NP_359356.1 15903806 933662 1731759..1731929 1 NC_003098.1 hypothetical protein 1731929 933662 spr1764 Streptococcus pneumoniae R6 hypothetical protein NP_359356.1 1731759 D 171101 CDS NP_359357.1 15903807 933661 1732032..1732256 1 NC_003098.1 hypothetical protein 1732256 933661 spr1765 Streptococcus pneumoniae R6 hypothetical protein NP_359357.1 1732032 D 171101 CDS NP_359358.1 15903808 933653 1732263..1732451 1 NC_003098.1 hypothetical protein 1732451 933653 spr1766 Streptococcus pneumoniae R6 hypothetical protein NP_359358.1 1732263 D 171101 CDS NP_359359.1 15903809 933659 1732567..1735557 1 NC_003098.1 bacteriocin formation protein 1735557 cylM 933659 cylM Streptococcus pneumoniae R6 bacteriocin formation protein NP_359359.1 1732567 D 171101 CDS NP_359360.1 15903810 933658 1735907..1736611 1 NC_003098.1 Related to Trp repressor binding protein; hypothetical protein 1736611 933658 spr1768 Streptococcus pneumoniae R6 hypothetical protein NP_359360.1 1735907 D 171101 CDS NP_359361.1 15903811 933650 1736592..1737521 1 NC_003098.1 hypothetical protein 1737521 933650 spr1769 Streptococcus pneumoniae R6 hypothetical protein NP_359361.1 1736592 D 171101 CDS NP_359362.1 15903812 933656 1737518..1739626 1 NC_003098.1 toxin secretion ABC transporter ATP-binding/permease 1739626 clyB 933656 clyB Streptococcus pneumoniae R6 toxin secretion ABC transporter ATP-binding/permease NP_359362.1 1737518 D 171101 CDS NP_359363.1 15903813 933654 1739650..1741389 1 NC_003098.1 subtilisin-like serine protease 1741389 nisP 933654 nisP Streptococcus pneumoniae R6 subtilisin-like serine protease NP_359363.1 1739650 D 171101 CDS NP_359364.1 15903814 933646 1741440..1742207 1 NC_003098.1 hypothetical protein 1742207 933646 spr1772 Streptococcus pneumoniae R6 hypothetical protein NP_359364.1 1741440 D 171101 CDS NP_359365.1 15903815 933652 1742209..1742841 1 NC_003098.1 ABC transporter ATP-binding protein 1742841 ABC-NBD 933652 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_359365.1 1742209 D 171101 CDS NP_359367.1 15903817 933643 complement(1743787..1744200) 1 NC_003098.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1744200 ndk 933643 ndk Streptococcus pneumoniae R6 nucleoside diphosphate kinase NP_359367.1 1743787 R 171101 CDS NP_359368.1 15903818 933649 complement(1744311..1747988) 1 NC_003098.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 1747988 rpoC 933649 rpoC Streptococcus pneumoniae R6 DNA-directed RNA polymerase subunit beta' NP_359368.1 1744311 R 171101 CDS NP_359369.1 15903819 933647 complement(1748021..1751671) 1 NC_003098.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1751671 rpoB 933647 rpoB Streptococcus pneumoniae R6 DNA-directed RNA polymerase subunit beta NP_359369.1 1748021 R 171101 CDS NP_359370.1 15903820 933644 complement(1752316..1753647) 1 NC_003098.1 hemolysin 1753647 hlyX 933644 hlyX Streptococcus pneumoniae R6 hemolysin NP_359370.1 1752316 R 171101 CDS NP_359371.1 15903821 933636 complement(1753876..1754700) 1 NC_003098.1 DNA-entry nuclease 1754700 endA 933636 endA Streptococcus pneumoniae R6 DNA-entry nuclease NP_359371.1 1753876 R 171101 CDS NP_359372.1 15903822 933642 complement(1754739..1754945) 1 NC_003098.1 hypothetical protein 1754945 epuA 933642 epuA Streptococcus pneumoniae R6 hypothetical protein NP_359372.1 1754739 R 171101 CDS NP_359373.1 15903823 933641 complement(1754920..1756203) 1 NC_003098.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1756203 murA 933641 murA Streptococcus pneumoniae R6 UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_359373.1 1754920 R 171101 CDS YP_008719807.1 555247353 17374512 complement(1756227..1756457) 1 NC_003098.1 hypothetical protein 1756457 17374512 spr1781a Streptococcus pneumoniae R6 hypothetical protein YP_008719807.1 1756227 R 171101 CDS NP_359374.1 15903824 933633 complement(1756515..1757552) 1 NC_003098.1 hypothetical protein 1757552 933633 spr1782 Streptococcus pneumoniae R6 hypothetical protein NP_359374.1 1756515 R 171101 CDS NP_359375.1 15903825 933639 complement(1757536..1758024) 1 NC_003098.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1758024 coaD 933639 coaD Streptococcus pneumoniae R6 phosphopantetheine adenylyltransferase NP_359375.1 1757536 R 171101 CDS NP_359376.1 15903826 933637 complement(1758014..1758553) 1 NC_003098.1 Probable methylase; type II DNA modification methyltransferase 1758553 933637 spr1784 Streptococcus pneumoniae R6 type II DNA modification methyltransferase NP_359376.1 1758014 R 171101 CDS NP_359377.1 15903827 933629 complement(1758618..1759616) 1 NC_003098.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 1759616 asnA 933629 asnA Streptococcus pneumoniae R6 asparagine synthetase AsnA NP_359377.1 1758618 R 171101 CDS NP_359379.1 15903829 933634 complement(1759722..1760429) 1 NC_003098.1 transmembrane protein; hypothetical protein 1760429 933634 spr1787 Streptococcus pneumoniae R6 hypothetical protein NP_359379.1 1759722 R 171101 CDS NP_359380.1 15903830 933626 complement(1760461..1761219) 1 NC_003098.1 rRNA/tRNA methylase 1761219 yjfA 933626 yjfA Streptococcus pneumoniae R6 rRNA/tRNA methylase NP_359380.1 1760461 R 171101 CDS NP_359381.1 15903831 933631 1761235..1761513 1 NC_003098.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1761513 acyP 933631 acyP Streptococcus pneumoniae R6 acylphosphatase NP_359381.1 1761235 D 171101 CDS NP_359382.1 15903832 933632 1761591..1762517 1 NC_003098.1 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein 1762517 933632 spr1790 Streptococcus pneumoniae R6 OxaA-like protein NP_359382.1 1761591 D 171101 CDS NP_359383.1 15903833 933619 complement(1762592..1763386) 1 NC_003098.1 pyruvate-formate lyase activating enzyme 1763386 pflC 933619 pflC Streptococcus pneumoniae R6 pyruvate-formate lyase activating enzyme NP_359383.1 1762592 R 171101 CDS NP_359384.1 15903834 933628 complement(1763512..1764762) 1 NC_003098.1 diaminopimelate decarboxylase 1764762 lysA 933628 lysA Streptococcus pneumoniae R6 diaminopimelate decarboxylase NP_359384.1 1763512 R 171101 CDS NP_359385.1 15903835 933627 complement(1764829..1765656) 1 NC_003098.1 pur operon repressor 1765656 purR 933627 purR Streptococcus pneumoniae R6 pur operon repressor NP_359385.1 1764829 R 171101 CDS NP_359386.1 15903836 933622 complement(1765923..1766927) 1 NC_003098.1 cmp-binding-factor 1 1766927 cbf1 933622 cbf1 Streptococcus pneumoniae R6 cmp-binding-factor 1 NP_359386.1 1765923 R 171101 CDS NP_359387.1 15903837 933621 complement(1766854..1768152) 1 NC_003098.1 hypothetical protein 1768152 933621 spr1795 Streptococcus pneumoniae R6 hypothetical protein NP_359387.1 1766854 R 171101 CDS NP_359388.1 15903838 933613 complement(1768112..1768795) 1 NC_003098.1 hypothetical protein 1768795 933613 spr1796 Streptococcus pneumoniae R6 hypothetical protein NP_359388.1 1768112 R 171101 CDS NP_359389.1 15903839 933617 complement(1768737..1769393) 1 NC_003098.1 ribulose-phosphate 3-epimerase 1769393 rpe 933617 rpe Streptococcus pneumoniae R6 ribulose-phosphate 3-epimerase NP_359389.1 1768737 R 171101 CDS NP_359390.1 15903840 933616 complement(1769404..1770282) 1 NC_003098.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 1770282 933616 spr1798 Streptococcus pneumoniae R6 ribosome-associated GTPase NP_359390.1 1769404 R 171101 CDS NP_359391.1 15903841 933610 complement(1770284..1771156) 1 NC_003098.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1771156 ksgA 933610 ksgA Streptococcus pneumoniae R6 dimethyladenosine transferase NP_359391.1 1770284 R 171101 CDS NP_359392.1 15903842 933615 complement(1771287..1771601) 1 NC_003098.1 hypothetical protein 1771601 933615 spr1800 Streptococcus pneumoniae R6 hypothetical protein NP_359392.1 1771287 R 171101 CDS NP_359393.1 15903843 933614 complement(1771588..1772229) 1 NC_003098.1 ABC transporter ATP-binding protein 1772229 ABC-NBD 933614 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_359393.1 1771588 R 171101 CDS NP_359394.1 15903844 933608 complement(1772231..1774273) 1 NC_003098.1 immunity protein; hypothetical protein 1774273 933608 spr1802 Streptococcus pneumoniae R6 hypothetical protein NP_359394.1 1772231 R 171101 CDS NP_359395.1 15903845 933612 complement(1774530..1775429) 1 NC_003098.1 transcriptional regulator PlcR 1775429 plcR 933612 plcR Streptococcus pneumoniae R6 transcriptional regulator PlcR NP_359395.1 1774530 R 171101 CDS NP_359396.1 15903846 933611 complement(1775501..1776061) 1 NC_003098.1 Primase-related protein; primase-related protein 1776061 933611 spr1804 Streptococcus pneumoniae R6 primase-related protein NP_359396.1 1775501 R 171101 CDS NP_359397.1 15903847 933604 complement(1776061..1776834) 1 NC_003098.1 hypothetical protein 1776834 933604 spr1805 Streptococcus pneumoniae R6 hypothetical protein NP_359397.1 1776061 R 171101 CDS NP_359398.1 15903848 933609 complement(1777140..1777805) 1 NC_003098.1 cell wall surface anchor family protein 1777805 933609 spr1806 Streptococcus pneumoniae R6 cell wall surface anchor family protein NP_359398.1 1777140 R 171101 CDS NP_359399.1 15903849 933601 complement(1778068..1778202) 1 NC_003098.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 1778202 rpmH 933601 rpmH Streptococcus pneumoniae R6 50S ribosomal protein L34 NP_359399.1 1778068 R 171101 CDS NP_359400.1 15903850 933607 complement(1778347..1779561) 1 NC_003098.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 1779561 aspC 933607 aspC Streptococcus pneumoniae R6 aminotransferase NP_359400.1 1778347 R 171101 CDS NP_359401.1 15903851 933606 complement(1779717..1780025) 1 NC_003098.1 hypothetical protein 1780025 933606 spr1809 Streptococcus pneumoniae R6 hypothetical protein NP_359401.1 1779717 R 171101 CDS NP_359402.1 15903852 933599 1780109..1780624 1 NC_003098.1 hypothetical protein 1780624 933599 spr1810 Streptococcus pneumoniae R6 hypothetical protein NP_359402.1 1780109 D 171101 CDS NP_359403.1 15903853 933603 complement(1780659..1782077) 1 NC_003098.1 Cof family protein 1782077 933603 spr1811 Streptococcus pneumoniae R6 Cof family protein NP_359403.1 1780659 R 171101 CDS NP_359404.1 15903854 933602 1782113..1783075 1 NC_003098.1 L-asparaginase 1783075 ansB 933602 ansB Streptococcus pneumoniae R6 L-asparaginase NP_359404.1 1782113 D 171101 CDS YP_008719808.1 555247354 17374513 complement(1783072..1783263) 1 NC_003098.1 hypothetical protein 1783263 17374513 spr1812a Streptococcus pneumoniae R6 hypothetical protein YP_008719808.1 1783072 R 171101 CDS NP_359405.1 15903855 933600 complement(1783327..1784367) 1 NC_003098.1 catabolite control protein A 1784367 ccpA 933600 ccpA Streptococcus pneumoniae R6 catabolite control protein A NP_359405.1 1783327 R 171101 CDS NP_359406.1 15903856 933595 complement(1784762..1785361) 1 NC_003098.1 DNA-binding response regulator 1785361 rr11 933595 rr11 Streptococcus pneumoniae R6 DNA-binding response regulator NP_359406.1 1784762 R 171101 CDS NP_359407.1 15903857 933598 complement(1785363..1786460) 1 NC_003098.1 sensor histidine kinase 1786460 hk11 933598 hk11 Streptococcus pneumoniae R6 sensor histidine kinase NP_359407.1 1785363 R 171101 CDS NP_359408.1 15903858 933597 complement(1786460..1787227) 1 NC_003098.1 hypothetical protein 1787227 933597 spr1816 Streptococcus pneumoniae R6 hypothetical protein NP_359408.1 1786460 R 171101 CDS NP_359409.1 15903859 933591 complement(1787199..1788083) 1 NC_003098.1 ABC transporter ATP-binding protein 1788083 ABC-NBD 933591 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_359409.1 1787199 R 171101 CDS NP_359410.1 15903860 933596 complement(1788261..1788467) 1 NC_003098.1 hypothetical protein 1788467 933596 spr1818 Streptococcus pneumoniae R6 hypothetical protein NP_359410.1 1788261 R 171101 CDS NP_359411.1 15903861 933573 complement(1795146..1795625) 1 NC_003098.1 sigma factor; competence-specific global transcription modulator 1795625 comX2 933573 comX2 Streptococcus pneumoniae R6 competence-specific global transcription modulator NP_359411.1 1795146 R 171101 CDS NP_359412.1 15903862 933572 complement(1795747..1796298) 1 NC_003098.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 1796298 nusG 933572 nusG Streptococcus pneumoniae R6 transcription antitermination protein NusG NP_359412.1 1795747 R 171101 CDS NP_359413.1 15903863 933566 complement(1796338..1796514) 1 NC_003098.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1796514 secE 933566 secE Streptococcus pneumoniae R6 preprotein translocase subunit SecE NP_359413.1 1796338 R 171101 CDS NP_359414.1 15903864 933570 complement(1796524..1796676) 1 NC_003098.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 1796676 rpmG 933570 rpmG Streptococcus pneumoniae R6 50S ribosomal protein L33 NP_359414.1 1796524 R 171101 CDS NP_359415.1 15903865 933569 complement(1796729..1798924) 1 NC_003098.1 penicillin-binding protein 2A 1798924 pbp2a 933569 pbp2a Streptococcus pneumoniae R6 penicillin-binding protein 2A NP_359415.1 1796729 R 171101 CDS NP_359416.1 15903866 933563 1799011..1799886 1 NC_003098.1 ribosomal large subunit pseudouridine synthase D 1799886 rluD 933563 rluD Streptococcus pneumoniae R6 ribosomal large subunit pseudouridine synthase D NP_359416.1 1799011 D 171101 CDS NP_359417.1 15903867 933568 complement(1799954..1801033) 1 NC_003098.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase 1801033 gapA 933568 gapA Streptococcus pneumoniae R6 glyceraldehyde-3-phosphate dehydrogenase NP_359417.1 1799954 R 171101 CDS NP_359418.1 15903868 933567 complement(1801138..1802118) 1 NC_003098.1 hypothetical protein 1802118 933567 spr1826 Streptococcus pneumoniae R6 hypothetical protein NP_359418.1 1801138 R 171101 CDS NP_359420.1 15903870 933565 complement(1802664..1803011) 1 NC_003098.1 transposase 1803011 transposase_A 933565 transposase_A Streptococcus pneumoniae R6 transposase NP_359420.1 1802664 R 171101 CDS NP_359421.1 15903871 933564 complement(1803124..1804023) 1 NC_003098.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1804023 nadC 933564 nadC Streptococcus pneumoniae R6 nicotinate-nucleotide pyrophosphorylase NP_359421.1 1803124 R 171101 CDS NP_359422.1 15903872 933778 1804233..1805543 1 NC_003098.1 integral membrane protein; hypothetical protein 1805543 933778 spr1830 Streptococcus pneumoniae R6 hypothetical protein NP_359422.1 1804233 D 171101 CDS NP_359423.1 15903873 933562 complement(1805909..1806103) 1 NC_003098.1 hypothetical protein 1806103 933562 spr1831 Streptococcus pneumoniae R6 hypothetical protein NP_359423.1 1805909 R 171101 CDS NP_359424.1 15903874 933801 complement(1806563..1807291) 1 NC_003098.1 transcription regulator; hypothetical protein 1807291 933801 spr1832 Streptococcus pneumoniae R6 hypothetical protein NP_359424.1 1806563 R 171101 CDS NP_359425.1 15903875 933560 1807407..1808858 1 NC_003098.1 beta-glucosidase 1808858 bgl2 933560 bgl2 Streptococcus pneumoniae R6 beta-glucosidase NP_359425.1 1807407 D 171101 CDS NP_359426.1 15903876 933775 1808876..1810171 1 NC_003098.1 PTS system transporter subunit IIC 1810171 ptcC 933775 ptcC Streptococcus pneumoniae R6 PTS system transporter subunit IIC NP_359426.1 1808876 D 171101 CDS NP_359427.1 15903877 933815 1810176..1810484 1 NC_003098.1 PTS system transporter subunit IIB 1810484 ptcB 933815 ptcB Streptococcus pneumoniae R6 PTS system transporter subunit IIB NP_359427.1 1810176 D 171101 CDS NP_359428.1 15903878 933795 1810463..1810789 1 NC_003098.1 PTS system transporter subunit IIA 1810789 ptcA 933795 ptcA Streptococcus pneumoniae R6 PTS system transporter subunit IIA NP_359428.1 1810463 D 171101 CDS NP_359429.1 15903879 933809 complement(1811697..1814369) 1 NC_003098.1 bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1814369 adhE 933809 adhE Streptococcus pneumoniae R6 bifunctional acetaldehyde-CoA/alcohol dehydrogenase NP_359429.1 1811697 R 171101 CDS NP_359430.1 15903880 933811 complement(1814648..1815058) 1 NC_003098.1 hypothetical protein 1815058 933811 spr1838 Streptococcus pneumoniae R6 hypothetical protein NP_359430.1 1814648 R 171101 CDS NP_359431.1 15903881 933856 complement(1815060..1815488) 1 NC_003098.1 protein-tyrosine-phosphatase; phosphotyrosine protein phosphatase 1815488 933856 spr1839 Streptococcus pneumoniae R6 phosphotyrosine protein phosphatase NP_359431.1 1815060 R 171101 CDS NP_359432.1 15903882 933824 complement(1815535..1815834) 1 NC_003098.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 1815834 yajC 933824 yajC Streptococcus pneumoniae R6 preprotein translocase subunit YajC NP_359432.1 1815535 R 171101 CDS NP_359433.1 15903883 933829 complement(1815951..1817927) 1 NC_003098.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1817927 tktA 933829 tktA Streptococcus pneumoniae R6 transketolase NP_359433.1 1815951 R 171101 CDS NP_359434.1 15903884 933878 complement(1818041..1819132) 1 NC_003098.1 L-ascorbate 6-phosphate lactonase 1819132 933878 spr1842 Streptococcus pneumoniae R6 L-ascorbate 6-phosphate lactonase NP_359434.1 1818041 R 171101 CDS NP_359435.1 15903885 933847 complement(1819244..1820917) 1 NC_003098.1 transcriptional regulator; hypothetical protein 1820917 933847 spr1843 Streptococcus pneumoniae R6 hypothetical protein NP_359435.1 1819244 R 171101 CDS NP_359436.1 15903886 933851 complement(1821096..1821800) 1 NC_003098.1 catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase 1821800 araD 933851 araD Streptococcus pneumoniae R6 L-ribulose-5-phosphate 4-epimerase NP_359436.1 1821096 R 171101 CDS NP_359437.1 15903887 933901 complement(1821802..1822665) 1 NC_003098.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase 1822665 sga 933901 sga Streptococcus pneumoniae R6 L-xylulose 5-phosphate 3-epimerase NP_359437.1 1821802 R 171101 CDS NP_359438.2 161410737 933867 complement(1822669..1823334) 1 NC_003098.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 1823334 ulaD 933867 ulaD Streptococcus pneumoniae R6 3-keto-L-gulonate-6-phosphate decarboxylase NP_359438.2 1822669 R 171101 CDS NP_359439.1 15903889 933871 complement(1823351..1823836) 1 NC_003098.1 PTS system transporter subunit IIA 1823836 PTS-EII 933871 PTS-EII Streptococcus pneumoniae R6 PTS system transporter subunit IIA NP_359439.1 1823351 R 171101 CDS NP_359440.1 15903890 933915 complement(1823913..1824194) 1 NC_003098.1 PTS system transporter subunit IIB 1824194 PTS-EII 933915 PTS-EII Streptococcus pneumoniae R6 PTS system transporter subunit IIB NP_359440.1 1823913 R 171101 CDS NP_359441.2 161410736 933892 complement(1824217..1825674) 1 NC_003098.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 1825674 ulaA 933892 ulaA Streptococcus pneumoniae R6 PTS system ascorbate-specific transporter subunit IIC NP_359441.2 1824217 R 171101 CDS NP_359442.1 15903892 933898 complement(1825805..1826428) 1 NC_003098.1 hypothetical protein 1826428 933898 spr1850 Streptococcus pneumoniae R6 hypothetical protein NP_359442.1 1825805 R 171101 CDS NP_359443.1 15903893 933938 complement(1826479..1827465) 1 NC_003098.1 hypothetical protein 1827465 933938 spr1851 Streptococcus pneumoniae R6 hypothetical protein NP_359443.1 1826479 R 171101 CDS NP_359444.1 15903894 933908 complement(1827484..1828314) 1 NC_003098.1 Similar to Bacillus subtilis SpoIIIJ; SpoIIIJ family protein 1828314 933908 spr1852 Streptococcus pneumoniae R6 SpoIIIJ family protein NP_359444.1 1827484 R 171101 CDS NP_359445.1 15903895 933911 complement(1828283..1828654) 1 NC_003098.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 1828654 rnpA 933911 rnpA Streptococcus pneumoniae R6 ribonuclease P NP_359445.1 1828283 R 171101 CDS NP_359446.1 15903896 933975 complement(1828803..1829993) 1 NC_003098.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 1829993 ackA 933975 ackA Streptococcus pneumoniae R6 acetate kinase NP_359446.1 1828803 R 171101 CDS NP_359447.1 15903897 933926 complement(1830044..1830997) 1 NC_003098.1 hypothetical protein 1830997 933926 spr1855 Streptococcus pneumoniae R6 hypothetical protein NP_359447.1 1830044 R 171101 CDS NP_359450.1 15903900 933961 complement(1831789..1832202) 1 NC_003098.1 hypothetical protein 1832202 933961 spr1858 Streptococcus pneumoniae R6 hypothetical protein NP_359450.1 1831789 R 171101 CDS NP_359451.1 15903901 933974 complement(1832180..1832686) 1 NC_003098.1 Competence induced; related to comYD; hypothetical protein 1832686 933974 spr1859 Streptococcus pneumoniae R6 hypothetical protein NP_359451.1 1832180 R 171101 CDS NP_359452.1 15903902 933985 complement(1832869..1833351) 1 NC_003098.1 Competence induced; comG-like protein D; competence protein CglD 1833351 cglD 933985 cglD Streptococcus pneumoniae R6 competence protein CglD NP_359452.1 1832869 R 171101 CDS NP_359453.1 15903903 933977 complement(1833266..1833592) 1 NC_003098.1 Competence induced; comG-like protein C; competence protein CglC 1833592 cglC 933977 cglC Streptococcus pneumoniae R6 competence protein CglC NP_359453.1 1833266 R 171101 CDS NP_359454.1 15903904 933980 complement(1833594..1834685) 1 NC_003098.1 Competence induced; comG-like protein B; competence protein CglB 1834685 cglB 933980 cglB Streptococcus pneumoniae R6 competence protein CglB NP_359454.1 1833594 R 171101 CDS NP_359455.1 15903905 933989 complement(1834558..1835499) 1 NC_003098.1 Competence induced; comG-like protein A; Also known as cilD; competence protein CglA 1835499 cglA 933989 cglA Streptococcus pneumoniae R6 competence protein CglA NP_359455.1 1834558 R 171101 CDS NP_359456.1 15903906 933983 complement(1835575..1835946) 1 NC_003098.1 DNA binding protein; hypothetical protein 1835946 933983 spr1865 Streptococcus pneumoniae R6 hypothetical protein NP_359456.1 1835575 R 171101 CDS NP_359457.1 15903907 933984 complement(1836091..1837149) 1 NC_003098.1 zinc-containing alcohol dehydrogenase 1837149 adh 933984 adh Streptococcus pneumoniae R6 zinc-containing alcohol dehydrogenase NP_359457.1 1836091 R 171101 CDS NP_359458.1 15903908 933992 complement(1837312..1838463) 1 NC_003098.1 N-acetylglucosamine-6-phosphate deacetylase 1838463 nagA 933992 nagA Streptococcus pneumoniae R6 N-acetylglucosamine-6-phosphate deacetylase NP_359458.1 1837312 R 171101 CDS NP_359459.1 15903909 933986 complement(1838616..1840433) 1 NC_003098.1 hypothetical protein 1840433 933986 spr1868 Streptococcus pneumoniae R6 hypothetical protein NP_359459.1 1838616 R 171101 CDS NP_359460.1 15903910 933988 complement(1840531..1841673) 1 NC_003098.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 1841673 tgt 933988 tgt Streptococcus pneumoniae R6 queuine tRNA-ribosyltransferase NP_359460.1 1840531 R 171101 CDS NP_359461.1 15903911 933994 1841803..1842660 1 NC_003098.1 hypothetical protein 1842660 933994 spr1870 Streptococcus pneumoniae R6 hypothetical protein NP_359461.1 1841803 D 171101 CDS NP_359465.1 15903915 933993 complement(1843781..1844119) 1 NC_003098.1 MarR family transcriptional regulator 1844119 marR 933993 marR Streptococcus pneumoniae R6 MarR family transcriptional regulator NP_359465.1 1843781 R 171101 CDS NP_359466.1 15903916 934001 complement(1844525..1845667) 1 NC_003098.1 Probable group B streptococcal surface immunogenic protein; hypothetical protein 1845667 934001 spr1875 Streptococcus pneumoniae R6 hypothetical protein NP_359466.1 1844525 R 171101 CDS NP_359467.1 15903917 933995 complement(1845833..1846453) 1 NC_003098.1 Low similarity to phosphoglycolate phosphatase; hypothetical protein 1846453 933995 spr1876 Streptococcus pneumoniae R6 hypothetical protein NP_359467.1 1845833 R 171101 CDS NP_359468.1 15903918 933996 complement(1846457..1847737) 1 NC_003098.1 MATE family transporter 1847737 MATE_transporter 933996 MATE_transporter Streptococcus pneumoniae R6 MATE family transporter NP_359468.1 1846457 R 171101 CDS NP_359469.1 15903919 934003 complement(1847798..1849282) 1 NC_003098.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1849282 thrC 934003 thrC Streptococcus pneumoniae R6 threonine synthase NP_359469.1 1847798 R 171101 CDS NP_359470.1 15903920 933999 complement(1849358..1850635) 1 NC_003098.1 hypothetical protein 1850635 933999 spr1879 Streptococcus pneumoniae R6 hypothetical protein NP_359470.1 1849358 R 171101 CDS NP_359471.1 15903921 934018 complement(1857099..1857533) 1 NC_003098.1 Low similarity to cytidine/deoxycytidylate deaminases; cytidine/deoxycytidylate deaminase 1857533 934018 spr1880 Streptococcus pneumoniae R6 cytidine/deoxycytidylate deaminase NP_359471.1 1857099 R 171101 CDS NP_359472.1 15903922 934019 complement(1857547..1859007) 1 NC_003098.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 1859007 gltX 934019 gltX Streptococcus pneumoniae R6 glutamyl-tRNA synthetase NP_359472.1 1857547 R 171101 CDS NP_359473.1 15903923 934060 complement(1859131..1860480) 1 NC_003098.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1860480 pgi 934060 pgi Streptococcus pneumoniae R6 glucose-6-phosphate isomerase NP_359473.1 1859131 R 171101 CDS NP_359474.1 15903924 934022 complement(1860467..1860646) 1 NC_003098.1 hypothetical protein 1860646 934022 spr1883 Streptococcus pneumoniae R6 hypothetical protein NP_359474.1 1860467 R 171101 CDS NP_359475.1 15903925 934043 complement(1860650..1861387) 1 NC_003098.1 glutamine amidotransferase 1861387 guaA 934043 guaA Streptococcus pneumoniae R6 glutamine amidotransferase NP_359475.1 1860650 R 171101 CDS NP_359476.1 15903926 934071 complement(1861478..1863289) 1 NC_003098.1 ABC transporter ATP-binding protein/permease 1863289 ABC-NP 934071 ABC-NP Streptococcus pneumoniae R6 ABC transporter ATP-binding protein/permease NP_359476.1 1861478 R 171101 CDS NP_359478.1 15903928 934054 complement(1864031..1865725) 1 NC_003098.1 ABC transporter ATP-binding protein/permease 1865725 ABC-NP 934054 ABC-NP Streptococcus pneumoniae R6 ABC transporter ATP-binding protein/permease NP_359478.1 1864031 R 171101 CDS NP_359479.1 15903929 934113 complement(1865872..1868445) 1 NC_003098.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 1868445 hexA 934113 hexA Streptococcus pneumoniae R6 DNA mismatch repair protein MutS NP_359479.1 1865872 R 171101 CDS NP_359480.1 15903930 934064 complement(1868457..1868903) 1 NC_003098.1 arginine repressor ArgR 1868903 argR 934064 argR Streptococcus pneumoniae R6 arginine repressor ArgR NP_359480.1 1868457 R 171101 CDS NP_359481.1 15903931 934066 1869051..1870742 1 NC_003098.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1870742 argS 934066 argS Streptococcus pneumoniae R6 arginyl-tRNA synthetase NP_359481.1 1869051 D 171101 CDS NP_359482.1 15903932 934140 complement(1871057..1871446) 1 NC_003098.1 tranposase 1871446 IS1381 934140 IS1381 Streptococcus pneumoniae R6 tranposase NP_359482.1 1871057 R 171101 CDS NP_359483.1 15903933 934133 1871577..1872086 1 NC_003098.1 hypothetical protein 1872086 934133 spr1892 Streptococcus pneumoniae R6 hypothetical protein NP_359483.1 1871577 D 171101 CDS NP_359484.1 15903934 934134 1872170..1872877 1 NC_003098.1 response regulator 1872877 phoP_pnpR 934134 phoP_pnpR Streptococcus pneumoniae R6 response regulator NP_359484.1 1872170 D 171101 CDS NP_359485.1 15903935 934137 1872878..1874209 1 NC_003098.1 sensor histidine kinase PnpS 1874209 phoR-pnpS 934137 phoR-pnpS Streptococcus pneumoniae R6 sensor histidine kinase PnpS NP_359485.1 1872878 D 171101 CDS NP_359486.1 15903936 934120 1874313..1875251 1 NC_003098.1 phosphate ABC transporter substrate+B766-binding protein 1875251 pstS 934120 pstS Streptococcus pneumoniae R6 phosphate ABC transporter substrate+B766-binding protein NP_359486.1 1874313 D 171101 CDS NP_359487.1 15903937 934126 1875369..1876232 1 NC_003098.1 phosphate ABC transporter permease 1876232 pstC 934126 pstC Streptococcus pneumoniae R6 phosphate ABC transporter permease NP_359487.1 1875369 D 171101 CDS NP_359488.1 15903938 934117 1876225..1877040 1 NC_003098.1 phosphate ABC transporter permease 1877040 pstA 934117 pstA Streptococcus pneumoniae R6 phosphate ABC transporter permease NP_359488.1 1876225 D 171101 CDS NP_359489.1 15903939 934112 1877042..1877794 1 NC_003098.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1877794 pstB 934112 pstB Streptococcus pneumoniae R6 phosphate transporter ATP-binding protein NP_359489.1 1877042 D 171101 CDS NP_359490.1 15903940 934135 1877809..1878459 1 NC_003098.1 phosphate transporter PhoU 1878459 phoU 934135 phoU Streptococcus pneumoniae R6 phosphate transporter PhoU NP_359490.1 1877809 D 171101 CDS NP_359492.1 15903942 934138 complement(1879066..1879584) 1 NC_003098.1 Possible transcriptional regulator; transcriptional regulator 1879584 934138 spr1901 Streptococcus pneumoniae R6 transcriptional regulator NP_359492.1 1879066 R 171101 CDS NP_359493.1 15903943 934131 1879718..1880734 1 NC_003098.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1880734 gpsA 934131 gpsA Streptococcus pneumoniae R6 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase NP_359493.1 1879718 D 171101 CDS NP_359494.1 15903944 934139 1880756..1881655 1 NC_003098.1 UTP-glucose-1-phosphate uridylyltransferase 1881655 galU 934139 galU Streptococcus pneumoniae R6 UTP-glucose-1-phosphate uridylyltransferase NP_359494.1 1880756 D 171101 CDS NP_359495.1 15903945 934116 complement(1881722..1882402) 1 NC_003098.1 hypothetical protein 1882402 934116 spr1904 Streptococcus pneumoniae R6 hypothetical protein NP_359495.1 1881722 R 171101 CDS NP_359496.1 15903946 934123 complement(1882383..1882928) 1 NC_003098.1 Similar to 5-formyltetrahydrofolate cyclo-ligase; 5-formyltetrahydrofolate cyclo-ligase 1882928 934123 spr1905 Streptococcus pneumoniae R6 5-formyltetrahydrofolate cyclo-ligase NP_359496.1 1882383 R 171101 CDS NP_359497.1 15903947 934136 complement(1882934..1884064) 1 NC_003098.1 hypothetical protein 1884064 hipO 934136 hipO Streptococcus pneumoniae R6 hypothetical protein NP_359497.1 1882934 R 171101 CDS NP_359498.1 15903948 934124 complement(1884132..1884830) 1 NC_003098.1 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 1884830 dapD 934124 dapD Streptococcus pneumoniae R6 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase NP_359498.1 1884132 R 171101 CDS NP_359499.1 15903949 934127 complement(1885060..1886193) 1 NC_003098.1 hypothetical protein 1886193 934127 spr1908 Streptococcus pneumoniae R6 hypothetical protein NP_359499.1 1885060 R 171101 CDS NP_359500.1 15903950 934893 complement(1886036..1888501) 1 NC_003098.1 penicillin-binding protein 1B 1888501 pbp1b 934893 pbp1b Streptococcus pneumoniae R6 penicillin-binding protein 1B NP_359500.1 1886036 R 171101 CDS NP_359501.1 15903951 934128 1888643..1889899 1 NC_003098.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1889899 tyrS 934128 tyrS Streptococcus pneumoniae R6 tyrosyl-tRNA synthetase NP_359501.1 1888643 D 171101 CDS NP_359502.1 15903952 934119 complement(1889977..1892049) 1 NC_003098.1 metal/cation transporter P-type ATPase 1892049 ctpC 934119 ctpC Streptococcus pneumoniae R6 metal/cation transporter P-type ATPase NP_359502.1 1889977 R 171101 CDS NP_359503.1 15903953 934129 complement(1892042..1892353) 1 NC_003098.1 hypothetical protein 1892353 934129 spr1912 Streptococcus pneumoniae R6 hypothetical protein NP_359503.1 1892042 R 171101 CDS NP_359504.1 15903954 934132 1892472..1893320 1 NC_003098.1 rRNA (guanine-N1-)-methyltransferase 1893320 rrmA 934132 rrmA Streptococcus pneumoniae R6 rRNA (guanine-N1-)-methyltransferase NP_359504.1 1892472 D 171101 CDS NP_359505.1 15903955 934111 complement(1893836..1894042) 1 NC_003098.1 hypothetical protein 1894042 934111 spr1914 Streptococcus pneumoniae R6 hypothetical protein NP_359505.1 1893836 R 171101 CDS NP_359506.1 15903956 934130 1894119..1894691 1 NC_003098.1 hypothetical protein 1894691 934130 spr1915 Streptococcus pneumoniae R6 hypothetical protein NP_359506.1 1894119 D 171101 CDS NP_359507.1 15903957 932789 complement(1895736..1897994) 1 NC_003098.1 maltodextrin phosphorylase 1897994 malP 932789 malP Streptococcus pneumoniae R6 maltodextrin phosphorylase NP_359507.1 1895736 R 171101 CDS NP_359508.1 15903958 934839 complement(1898020..1899537) 1 NC_003098.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 1899537 malM 934839 malM Streptococcus pneumoniae R6 4-alpha-glucanotransferase NP_359508.1 1898020 R 171101 CDS NP_359509.1 15903959 932974 1900087..1901358 1 NC_003098.1 maltose/maltodextrin ABC transporter substrate+B616-binding protein 1901358 malX 932974 malX Streptococcus pneumoniae R6 maltose/maltodextrin ABC transporter substrate+B616-binding protein NP_359509.1 1900087 D 171101 CDS NP_359510.1 15903960 934838 1901454..1902761 1 NC_003098.1 maltodextrin ABC transporter permease 1902761 malC 934838 malC Streptococcus pneumoniae R6 maltodextrin ABC transporter permease NP_359510.1 1901454 D 171101 CDS NP_359511.1 15903961 932952 1902742..1903605 1 NC_003098.1 maltodextrin ABC transporter permease 1903605 malD 932952 malD Streptococcus pneumoniae R6 maltodextrin ABC transporter permease NP_359511.1 1902742 D 171101 CDS NP_359512.1 15903962 932980 1903858..1904658 1 NC_003098.1 MalA protein 1904658 malA 932980 malA Streptococcus pneumoniae R6 MalA protein NP_359512.1 1903858 D 171101 CDS NP_359513.1 15903963 934853 1904668..1905654 1 NC_003098.1 maltose operon transcriptional repressor 1905654 malR 934853 malR Streptococcus pneumoniae R6 maltose operon transcriptional repressor NP_359513.1 1904668 D 171101 CDS NP_359514.1 15903964 933407 complement(1905946..1906887) 1 NC_003098.1 hypothetical protein 1906887 933407 spr1923 Streptococcus pneumoniae R6 hypothetical protein NP_359514.1 1905946 R 171101 CDS NP_359515.1 15903965 934841 complement(1906865..1908628) 1 NC_003098.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1908628 aspS 934841 aspS Streptococcus pneumoniae R6 aspartyl-tRNA synthetase NP_359515.1 1906865 R 171101 CDS NP_359516.1 15903966 933582 complement(1908980..1909210) 1 NC_003098.1 hypothetical protein 1909210 933582 spr1925 Streptococcus pneumoniae R6 hypothetical protein NP_359516.1 1908980 R 171101 CDS NP_359517.1 15903967 933018 complement(1909228..1909869) 1 NC_003098.1 hypothetical protein 1909869 933018 spr1926 Streptococcus pneumoniae R6 hypothetical protein NP_359517.1 1909228 R 171101 CDS NP_359518.1 15903968 933014 complement(1909881..1910621) 1 NC_003098.1 hypothetical protein 1910621 933014 spr1927 Streptococcus pneumoniae R6 hypothetical protein NP_359518.1 1909881 R 171101 CDS NP_359519.1 15903969 934121 complement(1910618..1910818) 1 NC_003098.1 hypothetical protein 1910818 934121 spr1928 Streptococcus pneumoniae R6 hypothetical protein NP_359519.1 1910618 R 171101 CDS NP_359520.1 15903970 934842 complement(1910815..1911030) 1 NC_003098.1 transcriptional repressor protein; transcriptional regulator 1911030 934842 spr1929 Streptococcus pneumoniae R6 transcriptional regulator NP_359520.1 1910815 R 171101 CDS NP_359521.1 15903971 933027 complement(1911031..1911495) 1 NC_003098.1 hypothetical protein 1911495 933027 spr1930 Streptococcus pneumoniae R6 hypothetical protein NP_359521.1 1911031 R 171101 CDS NP_359522.1 15903972 934840 complement(1911671..1912960) 1 NC_003098.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 1912960 hisS 934840 hisS Streptococcus pneumoniae R6 histidyl-tRNA synthetase NP_359522.1 1911671 R 171101 CDS NP_359523.1 15903973 933004 complement(1913038..1914285) 1 NC_003098.1 permease; hypothetical protein 1914285 933004 spr1932 Streptococcus pneumoniae R6 hypothetical protein NP_359523.1 1913038 R 171101 CDS NP_359524.1 15903974 932938 complement(1914475..1915326) 1 NC_003098.1 positive transcriptional regulator of glucosyltransferase and Spp phenotype 1915326 rgg 932938 rgg Streptococcus pneumoniae R6 positive transcriptional regulator of glucosyltransferase and Spp phenotype NP_359524.1 1914475 R 171101 CDS NP_359525.1 15903975 933034 1915450..1915791 1 NC_003098.1 hypothetical protein 1915791 933034 spr1934 Streptococcus pneumoniae R6 hypothetical protein NP_359525.1 1915450 D 171101 CDS NP_359526.1 15903976 934050 complement(1916000..1917703) 1 NC_003098.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 1917703 ilvD 934050 ilvD Streptococcus pneumoniae R6 dihydroxy-acid dehydratase NP_359526.1 1916000 R 171101 CDS NP_359527.1 15903977 934843 complement(1917936..1918868) 1 NC_003098.1 transketolase C-terminal subunit 1918868 tktC 934843 tktC Streptococcus pneumoniae R6 transketolase C-terminal subunit NP_359527.1 1917936 R 171101 CDS NP_359528.1 15903978 933053 complement(1918865..1919722) 1 NC_003098.1 transketolase N-terminal section 1919722 tktN 933053 tktN Streptococcus pneumoniae R6 transketolase N-terminal section NP_359528.1 1918865 R 171101 CDS NP_359529.1 15903979 933025 complement(1919726..1921072) 1 NC_003098.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 1921072 ulaA 933025 ulaA Streptococcus pneumoniae R6 PTS system ascorbate-specific transporter subunit IIC NP_359529.1 1919726 R 171101 CDS NP_359530.1 15903980 934844 complement(1921085..1921369) 1 NC_003098.1 PTS system transporter subunit IIB 1921369 934844 spr1939 Streptococcus pneumoniae R6 PTS system transporter subunit IIB NP_359530.1 1921085 R 171101 CDS NP_359531.1 15903981 933065 complement(1921373..1923403) 1 NC_003098.1 Probable transcriptional antiterminator, bglG family; hypothetical protein 1923403 933065 spr1940 Streptococcus pneumoniae R6 hypothetical protein NP_359531.1 1921373 R 171101 CDS NP_359532.1 15903982 933064 1923594..1924601 1 NC_003098.1 hypothetical protein 1924601 933064 spr1941 Streptococcus pneumoniae R6 hypothetical protein NP_359532.1 1923594 D 171101 CDS NP_359533.1 15903983 933036 1924604..1924804 1 NC_003098.1 hypothetical protein 1924804 933036 spr1942 Streptococcus pneumoniae R6 hypothetical protein NP_359533.1 1924604 D 171101 CDS NP_359534.1 15903984 933000 1924956..1925138 1 NC_003098.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1925138 rpmF 933000 rpmF Streptococcus pneumoniae R6 50S ribosomal protein L32 NP_359534.1 1924956 D 171101 CDS NP_359535.1 15903985 934845 1925154..1925303 1 NC_003098.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1925303 rpmG 934845 rpmG Streptococcus pneumoniae R6 50S ribosomal protein L33 NP_359535.1 1925154 D 171101 CDS NP_359536.1 15903986 933069 complement(1925783..1927855) 1 NC_003098.1 choline binding protein PcpA 1927855 pcpA 933069 pcpA Streptococcus pneumoniae R6 choline binding protein PcpA NP_359536.1 1925783 R 171101 CDS NP_359537.1 15903987 933077 1928212..1928781 1 NC_003098.1 hypothetical protein 1928781 933077 spr1946 Streptococcus pneumoniae R6 hypothetical protein NP_359537.1 1928212 D 171101 CDS NP_359538.1 15903988 934847 1928807..1929196 1 NC_003098.1 tranposase 1929196 IS1381 934847 IS1381 Streptococcus pneumoniae R6 tranposase NP_359538.1 1928807 D 171101 CDS NP_359540.1 15903990 934846 complement(1929900..1931780) 1 NC_003098.1 glycosyl hydrolase-like protein 1931780 934846 spr1949 Streptococcus pneumoniae R6 glycosyl hydrolase-like protein NP_359540.1 1929900 R 171101 CDS NP_359541.1 15903991 933076 complement(1931774..1932655) 1 NC_003098.1 sugar operon regulatory protein; ROK family protein 1932655 933076 spr1950 Streptococcus pneumoniae R6 ROK family protein NP_359541.1 1931774 R 171101 CDS NP_359542.1 15903992 933083 complement(1932727..1935387) 1 NC_003098.1 Probable sugar hydrolase; hypothetical protein 1935387 933083 spr1951 Streptococcus pneumoniae R6 hypothetical protein NP_359542.1 1932727 R 171101 CDS NP_359543.1 15903993 933101 complement(1935463..1936767) 1 NC_003098.1 hypothetical protein 1936767 933101 spr1952 Streptococcus pneumoniae R6 hypothetical protein NP_359543.1 1935463 R 171101 CDS NP_359544.1 15903994 933282 1936914..1938998 1 NC_003098.1 Similar to a sugar hydrolase in Lactococcus lactis subsp. lactis; hypothetical protein 1938998 933282 spr1953 Streptococcus pneumoniae R6 hypothetical protein NP_359544.1 1936914 D 171101 CDS NP_359545.1 15903995 933075 complement(1939038..1940789) 1 NC_003098.1 hypothetical protein 1940789 933075 spr1954 Streptococcus pneumoniae R6 hypothetical protein NP_359545.1 1939038 R 171101 CDS NP_359548.1 15903998 932991 1942769..1943785 1 NC_003098.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 1943785 arcB 932991 arcB Streptococcus pneumoniae R6 ornithine carbamoyltransferase NP_359548.1 1942769 D 171101 CDS NP_359549.1 15903999 934851 1943950..1944897 1 NC_003098.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1944897 arcC 934851 arcC Streptococcus pneumoniae R6 carbamate kinase NP_359549.1 1943950 D 171101 CDS NP_359550.1 15904000 933363 1945106..1946617 1 NC_003098.1 hypothetical protein 1946617 933363 spr1959 Streptococcus pneumoniae R6 hypothetical protein NP_359550.1 1945106 D 171101 CDS NP_359551.1 15904001 933289 1946639..1947970 1 NC_003098.1 Probable Xaa-His dipeptidase; hypothetical protein 1947970 933289 spr1960 Streptococcus pneumoniae R6 hypothetical protein NP_359551.1 1946639 D 171101 CDS NP_359552.1 15904002 933261 complement(1948375..1948665) 1 NC_003098.1 hypothetical protein 1948665 933261 spr1961 Streptococcus pneumoniae R6 hypothetical protein NP_359552.1 1948375 R 171101 CDS NP_359553.1 15904003 933066 complement(1949304..1950203) 1 NC_003098.1 Probable member of SPFH domain/Band 7 family; hypothetical protein 1950203 933066 spr1962 Streptococcus pneumoniae R6 hypothetical protein NP_359553.1 1949304 R 171101 CDS NP_359554.1 15904004 933050 complement(1950333..1951484) 1 NC_003098.1 iron-containing alcohol dehydrogenase 1951484 adh2 933050 adh2 Streptococcus pneumoniae R6 iron-containing alcohol dehydrogenase NP_359554.1 1950333 R 171101 CDS NP_359555.1 15904005 933146 complement(1951630..1953396) 1 NC_003098.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 1953396 fucI 933146 fucI Streptococcus pneumoniae R6 L-fucose isomerase NP_359555.1 1951630 R 171101 CDS NP_359556.1 15904006 933903 complement(1953453..1956569) 1 NC_003098.1 fucolectin-related protein 1956569 933903 spr1965 Streptococcus pneumoniae R6 fucolectin-related protein NP_359556.1 1953453 R 171101 CDS NP_359557.1 15904007 934848 complement(1956579..1958873) 1 NC_003098.1 hypothetical protein 1958873 934848 spr1966 Streptococcus pneumoniae R6 hypothetical protein NP_359557.1 1956579 R 171101 CDS NP_359558.1 15904008 933119 complement(1958932..1959732) 1 NC_003098.1 PTS system transporter subunit IID 1959732 PTS-EII 933119 PTS-EII Streptococcus pneumoniae R6 PTS system transporter subunit IID NP_359558.1 1958932 R 171101 CDS NP_359559.1 15904009 933265 complement(1959729..1960502) 1 NC_003098.1 PTS system transporter subunit IIC 1960502 PTS-EII 933265 PTS-EII Streptococcus pneumoniae R6 PTS system transporter subunit IIC NP_359559.1 1959729 R 171101 CDS NP_359560.1 15904010 934849 complement(1960527..1960997) 1 NC_003098.1 PTS system transporter subunit IIB 1960997 PTS-EII 934849 PTS-EII Streptococcus pneumoniae R6 PTS system transporter subunit IIB NP_359560.1 1960527 R 171101 CDS NP_359561.1 15904011 933110 complement(1960988..1961434) 1 NC_003098.1 PTS system transporter subunit IIA 1961434 PTS-EII 933110 PTS-EII Streptococcus pneumoniae R6 PTS system transporter subunit IIA NP_359561.1 1960988 R 171101 CDS NP_359562.1 15904012 933886 complement(1961412..1961852) 1 NC_003098.1 fucose pathway protein 1961852 fucU 933886 fucU Streptococcus pneumoniae R6 fucose pathway protein NP_359562.1 1961412 R 171101 CDS NP_359563.1 15904013 932993 complement(1961864..1962517) 1 NC_003098.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 1962517 fucA 932993 fucA Streptococcus pneumoniae R6 L-fuculose phosphate aldolase NP_359563.1 1961864 R 171101 CDS NP_359564.1 15904014 932925 complement(1962617..1964065) 1 NC_003098.1 fucose kinase 1964065 fcsK 932925 fcsK Streptococcus pneumoniae R6 fucose kinase NP_359564.1 1962617 R 171101 CDS NP_359565.1 15904015 934850 1964196..1964969 1 NC_003098.1 fucose operon repressor 1964969 fcsR 934850 fcsR Streptococcus pneumoniae R6 fucose operon repressor NP_359565.1 1964196 D 171101 CDS NP_359566.1 15904016 933277 complement(1966098..1967603) 1 NC_003098.1 zinc ABC transporter substrate-binding protein 1967603 adcA 933277 adcA Streptococcus pneumoniae R6 zinc ABC transporter substrate-binding protein NP_359566.1 1966098 R 171101 CDS NP_359567.1 15904017 934852 complement(1967613..1968449) 1 NC_003098.1 zinc ABC transporter permease 1968449 adcB 934852 adcB Streptococcus pneumoniae R6 zinc ABC transporter permease NP_359567.1 1967613 R 171101 CDS NP_359568.1 15904018 933425 complement(1968412..1969116) 1 NC_003098.1 ABC transporter ATPase 1969116 adcC 933425 adcC Streptococcus pneumoniae R6 ABC transporter ATPase NP_359568.1 1968412 R 171101 CDS NP_359569.1 15904019 933868 complement(1969116..1969616) 1 NC_003098.1 adc operon repressor AdcR 1969616 adcR 933868 adcR Streptococcus pneumoniae R6 adc operon repressor AdcR NP_359569.1 1969116 R 171101 CDS NP_359570.1 15904020 933943 complement(1969711..1970994) 1 NC_003098.1 poly D-alanine transfer protein 1970994 dltD 933943 dltD Streptococcus pneumoniae R6 poly D-alanine transfer protein NP_359570.1 1969711 R 171101 CDS NP_359571.1 15904021 934854 complement(1970972..1971211) 1 NC_003098.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 1971211 dltC 934854 dltC Streptococcus pneumoniae R6 D-alanine--poly(phosphoribitol) ligase subunit 2 NP_359571.1 1970972 R 171101 CDS NP_359572.1 15904022 933707 complement(1971225..1972469) 1 NC_003098.1 D-alanine transfer from Dcp to undecaprenol-phosphate; activated D-alanine transport protein 1972469 dltB 933707 dltB Streptococcus pneumoniae R6 activated D-alanine transport protein NP_359572.1 1971225 R 171101 CDS NP_359573.1 15904023 934087 complement(1972466..1973932) 1 NC_003098.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 1973932 dltA 934087 dltA Streptococcus pneumoniae R6 D-alanine--poly(phosphoribitol) ligase subunit 1 NP_359573.1 1972466 R 171101 CDS NP_359574.1 15904024 933708 complement(1974482..1975660) 1 NC_003098.1 hypothetical protein 1975660 933708 spr1983 Streptococcus pneumoniae R6 hypothetical protein NP_359574.1 1974482 R 171101 CDS NP_359577.1 15904027 933486 1978504..1979091 1 NC_003098.1 hypothetical protein 1979091 933486 spr1986 Streptococcus pneumoniae R6 hypothetical protein NP_359577.1 1978504 D 171101 CDS NP_359578.1 15904028 934871 complement(1979178..1979381) 1 NC_003098.1 hypothetical protein 1979381 934871 spr1987 Streptococcus pneumoniae R6 hypothetical protein NP_359578.1 1979178 R 171101 CDS NP_359579.1 15904029 933711 complement(1979572..1980276) 1 NC_003098.1 glycerol uptake facilitator protein 1980276 glpF 933711 glpF Streptococcus pneumoniae R6 glycerol uptake facilitator protein NP_359579.1 1979572 R 171101 CDS NP_359582.1 15904032 933712 complement(1982216..1983724) 1 NC_003098.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 1983724 glpK 933712 glpK Streptococcus pneumoniae R6 glycerol kinase NP_359582.1 1982216 R 171101 CDS NP_359583.1 15904033 934088 complement(1983883..1985310) 1 NC_003098.1 hypothetical protein 1985310 934088 spr1992 Streptococcus pneumoniae R6 hypothetical protein NP_359583.1 1983883 R 171101 CDS NP_359584.1 15904034 934856 1985475..1986347 1 NC_003098.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 1986347 hslO 934856 hslO Streptococcus pneumoniae R6 Hsp33-like chaperonin NP_359584.1 1985475 D 171101 CDS NP_359585.1 15904035 933713 1986304..1987314 1 NC_003098.1 Falls into the same paralogous family as dihydroorotate dehydrogenase; hypothetical protein 1987314 933713 spr1994 Streptococcus pneumoniae R6 hypothetical protein NP_359585.1 1986304 D 171101 CDS NP_359586.1 15904036 933487 complement(1987544..1989649) 1 NC_003098.1 choline binding protein A 1989649 pspC 933487 pspC Streptococcus pneumoniae R6 choline binding protein A NP_359586.1 1987544 R 171101 CDS NP_359587.1 15904037 934857 complement(1989728..1990255) 1 NC_003098.1 hypothetical protein 1990255 934857 spr1996 Streptococcus pneumoniae R6 hypothetical protein NP_359587.1 1989728 R 171101 CDS NP_359588.1 15904038 933715 complement(1990338..1991669) 1 NC_003098.1 histidine kinase 1991669 hk06 933715 hk06 Streptococcus pneumoniae R6 histidine kinase NP_359588.1 1990338 R 171101 CDS NP_359589.1 15904039 934089 complement(1991666..1992319) 1 NC_003098.1 response regulator 1992319 rr06 934089 rr06 Streptococcus pneumoniae R6 response regulator NP_359589.1 1991666 R 171101 CDS NP_359592.1 15904042 933717 complement(1995395..1995916) 1 NC_003098.1 transcriptional regulator CtsR 1995916 ctsR 933717 ctsR Streptococcus pneumoniae R6 transcriptional regulator CtsR NP_359592.1 1995395 R 171101 CDS NP_359593.1 15904043 934094 complement(1995972..1996700) 1 NC_003098.1 ABC transporter ATP-binding protein 1996700 ABC-NBD 934094 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_359593.1 1995972 R 171101 CDS NP_359594.1 15904044 934861 complement(1996700..1997707) 1 NC_003098.1 ABC transporter substrate-binding protein 1997707 934861 spr2003 Streptococcus pneumoniae R6 ABC transporter substrate-binding protein NP_359594.1 1996700 R 171101 CDS NP_359595.1 15904045 933718 complement(1997745..1998506) 1 NC_003098.1 ABC transporter permease 1998506 ABC-MSP 933718 ABC-MSP Streptococcus pneumoniae R6 ABC transporter permease NP_359595.1 1997745 R 171101 CDS NP_359596.1 15904046 934092 complement(1998466..1998756) 1 NC_003098.1 hypothetical protein 1998756 934092 spr2005 Streptococcus pneumoniae R6 hypothetical protein NP_359596.1 1998466 R 171101 CDS NP_359597.1 15904047 934859 complement(1999012..2000358) 1 NC_003098.1 choline binding protein D 2000358 cbpD 934859 cbpD Streptococcus pneumoniae R6 choline binding protein D NP_359597.1 1999012 R 171101 CDS NP_359598.1 15904048 933719 complement(2000447..2000713) 1 NC_003098.1 hypothetical protein 2000713 933719 spr2007 Streptococcus pneumoniae R6 hypothetical protein NP_359598.1 2000447 R 171101 CDS NP_359599.1 15904049 933489 complement(2000715..2002067) 1 NC_003098.1 unwinds double stranded DNA; replicative DNA helicase 2002067 dnaC 933489 dnaC Streptococcus pneumoniae R6 replicative DNA helicase NP_359599.1 2000715 R 171101 CDS NP_359600.1 15904050 934865 complement(2002111..2002563) 1 NC_003098.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 2002563 rplI 934865 rplI Streptococcus pneumoniae R6 50S ribosomal protein L9 NP_359600.1 2002111 R 171101 CDS NP_359601.1 15904051 933720 complement(2002560..2004533) 1 NC_003098.1 Probable member of DHH superfamily; DHH subfamily 1 protein 2004533 933720 spr2010 Streptococcus pneumoniae R6 DHH subfamily 1 protein NP_359601.1 2002560 R 171101 CDS NP_359602.1 15904052 934097 complement(2004669..2005217) 1 NC_003098.1 Probable member of ribosomal protein S30AE family; ribosomal subunit interface protein 2005217 934097 spr2011 Streptococcus pneumoniae R6 ribosomal subunit interface protein NP_359602.1 2004669 R 171101 CDS NP_359603.1 15904053 934860 complement(2005297..2005959) 1 NC_003098.1 competence protein ComF 2005959 comFC 934860 comFC Streptococcus pneumoniae R6 competence protein ComF NP_359603.1 2005297 R 171101 CDS NP_359604.1 15904054 933722 complement(2005956..2007254) 1 NC_003098.1 helicase 2007254 comFA 933722 comFA Streptococcus pneumoniae R6 helicase NP_359604.1 2005956 R 171101 CDS NP_359605.1 15904055 934091 2007310..2007945 1 NC_003098.1 hypothetical protein 2007945 934091 spr2014 Streptococcus pneumoniae R6 hypothetical protein NP_359605.1 2007310 D 171101 CDS NP_359606.1 15904056 933723 2008230..2009150 1 NC_003098.1 cysteine synthase 2009150 cycK 933723 cycK Streptococcus pneumoniae R6 cysteine synthase NP_359606.1 2008230 D 171101 CDS NP_359607.1 15904057 933490 complement(2009347..2009616) 1 NC_003098.1 hypothetical protein 2009616 transposase_G 933490 transposase_G Streptococcus pneumoniae R6 hypothetical protein NP_359607.1 2009347 R 171101 CDS NP_359610.1 15904060 933725 complement(2010734..2011774) 1 NC_003098.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 2011774 tsf 933725 tsf Streptococcus pneumoniae R6 elongation factor Ts NP_359610.1 2010734 R 171101 CDS NP_359611.1 15904061 934093 complement(2011840..2012619) 1 NC_003098.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 2012619 rpsB 934093 rpsB Streptococcus pneumoniae R6 30S ribosomal protein S2 NP_359611.1 2011840 R 171101 CDS NP_359612.1 15904062 933726 complement(2012843..2014021) 1 NC_003098.1 general stress protein GSP-781 2014021 gsp-781 933726 gsp-781 Streptococcus pneumoniae R6 general stress protein GSP-781 NP_359612.1 2012843 R 171101 CDS NP_359613.1 15904063 933491 complement(2014115..2014609) 1 NC_003098.1 rod shpae-determining protein MreD 2014609 mreD 933491 mreD Streptococcus pneumoniae R6 rod shpae-determining protein MreD NP_359613.1 2014115 R 171101 CDS NP_359614.1 15904064 934863 complement(2014609..2015427) 1 NC_003098.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 2015427 mreC 934863 mreC Streptococcus pneumoniae R6 rod shape-determining protein MreC NP_359614.1 2014609 R 171101 CDS NP_359615.1 15904065 933727 complement(2015486..2016280) 1 NC_003098.1 ABC transporter permease 2016280 ABC-MSP 933727 ABC-MSP Streptococcus pneumoniae R6 ABC transporter permease NP_359615.1 2015486 R 171101 CDS NP_359616.1 15904066 934095 complement(2016273..2017112) 1 NC_003098.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 2017112 cbiO 934095 cbiO Streptococcus pneumoniae R6 cobalt transporter ATP-binding subunit NP_359616.1 2016273 R 171101 CDS NP_359617.1 15904067 934864 complement(2017097..2017924) 1 NC_003098.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 2017924 cbiO 934864 cbiO Streptococcus pneumoniae R6 cobalt transporter ATP-binding subunit NP_359617.1 2017097 R 171101 CDS NP_359618.1 15904068 933728 complement(2017921..2018466) 1 NC_003098.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 2018466 pgsA 933728 pgsA Streptococcus pneumoniae R6 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase NP_359618.1 2017921 R 171101 CDS NP_359619.1 15904069 934098 complement(2018477..2019307) 1 NC_003098.1 hypothetical protein 2019307 934098 spr2028 Streptococcus pneumoniae R6 hypothetical protein NP_359619.1 2018477 R 171101 CDS NP_359620.1 15904070 934872 complement(2019340..2020623) 1 NC_003098.1 Probable protease/peptidase; hypothetical protein 2020623 934872 spr2029 Streptococcus pneumoniae R6 hypothetical protein NP_359620.1 2019340 R 171101 CDS NP_359621.1 15904071 933729 complement(2020620..2021870) 1 NC_003098.1 hypothetical protein 2021870 933729 spr2030 Streptococcus pneumoniae R6 hypothetical protein NP_359621.1 2020620 R 171101 CDS NP_359622.1 15904072 934101 2022029..2022397 1 NC_003098.1 hypothetical protein 2022397 934101 spr2031 Streptococcus pneumoniae R6 hypothetical protein NP_359622.1 2022029 D 171101 CDS NP_359623.1 15904073 934866 2022400..2023497 1 NC_003098.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2023497 recF 934866 recF Streptococcus pneumoniae R6 recombination protein F NP_359623.1 2022400 D 171101 CDS NP_359624.1 15904074 933730 complement(2023548..2025026) 1 NC_003098.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2025026 imdH 933730 imdH Streptococcus pneumoniae R6 inosine 5'-monophosphate dehydrogenase NP_359624.1 2023548 R 171101 CDS NP_359625.1 15904075 933492 complement(2025178..2026203) 1 NC_003098.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II 2026203 trpS 933492 trpS Streptococcus pneumoniae R6 tryptophanyl-tRNA synthetase II NP_359625.1 2025178 R 171101 CDS NP_359626.1 15904076 934867 2026409..2028031 1 NC_003098.1 ABC transporter ATP-binding protein 2028031 ABC-NBD 934867 ABC-NBD Streptococcus pneumoniae R6 ABC transporter ATP-binding protein NP_359626.1 2026409 D 171101 CDS NP_359627.1 15904077 933731 2028093..2030645 1 NC_003098.1 ABC transporter permease 2030645 933731 spr2036 Streptococcus pneumoniae R6 ABC transporter permease NP_359627.1 2028093 D 171101 CDS NP_359631.1 15904081 934096 2032457..2032999 1 NC_003098.1 Probable transcriptional regulator of TetR family; hypothetical protein 2032999 934096 spr2040 Streptococcus pneumoniae R6 hypothetical protein NP_359631.1 2032457 D 171101 CDS NP_359632.1 15904082 933733 complement(2033242..2033994) 1 NC_003098.1 Required for induction of competence; response regulator 2033994 comE 933733 comE Streptococcus pneumoniae R6 response regulator NP_359632.1 2033242 R 171101 CDS NP_359633.1 15904083 934103 complement(2033991..2035316) 1 NC_003098.1 Required for induction of competence; sensor histidine kinase ComD 2035316 comD 934103 comD Streptococcus pneumoniae R6 sensor histidine kinase ComD NP_359633.1 2033991 R 171101 CDS NP_359634.1 15904084 934870 complement(2035337..2035462) 1 NC_003098.1 competence stimulating peptide 2035462 comC 934870 comC Streptococcus pneumoniae R6 competence stimulating peptide NP_359634.1 2035337 R 171101 CDS NP_359635.1 15904085 933736 complement(2035744..2036223) 1 NC_003098.1 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 2036223 933736 spr2044 Streptococcus pneumoniae R6 rRNA large subunit methyltransferase NP_359635.1 2035744 R 171101 CDS NP_359636.1 15904086 934102 2036394..2037587 1 NC_003098.1 serine protease 2037587 sphtra 934102 sphtra Streptococcus pneumoniae R6 serine protease NP_359636.1 2036394 D 171101 CDS NP_359637.1 15904087 933738 2037645..2038403 1 NC_003098.1 chromosome segregation protein 2038403 spo0J 933738 spo0J Streptococcus pneumoniae R6 chromosome segregation protein NP_359637.1 2037645 D 171101 CDS