-- dump date 20140620_084927 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 171101000001 SEQ_END SEQ_END NC_003098.1 2038615 2038615 DR NC_003098.1; contig end 2038615..2038615 Streptococcus pneumoniae R6 NP_357595.1 CDS dnaA NC_003098.1 1 1362 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1..1362 Streptococcus pneumoniae R6 932985 NP_357596.1 CDS dnaN NC_003098.1 1521 2657 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1521..2657 Streptococcus pneumoniae R6 933376 NP_357597.1 CDS spr0003 NC_003098.1 2722 2916 D hypothetical protein 2722..2916 Streptococcus pneumoniae R6 932878 NP_357598.1 CDS spr0004 NC_003098.1 3000 4115 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 3000..4115 Streptococcus pneumoniae R6 933428 NP_357599.1 CDS pth NC_003098.1 4186 4755 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4186..4755 Streptococcus pneumoniae R6 933315 NP_357600.1 CDS mfd NC_003098.1 4756 8265 D transcription-repair coupling factor 4756..8265 Streptococcus pneumoniae R6 933199 NP_357601.1 CDS spr0007 NC_003098.1 8323 8589 D S4 domain-containing protein 8323..8589 Streptococcus pneumoniae R6 933324 NP_357602.1 CDS spr0008 NC_003098.1 8582 8950 D hypothetical protein 8582..8950 Streptococcus pneumoniae R6 933400 NP_357603.1 CDS spr0009 NC_003098.1 9001 10338 D hypothetical protein 9001..10338 Streptococcus pneumoniae R6 933406 NP_357604.1 CDS spr0010 NC_003098.1 10335 11612 D cell cycle protein of the MesJ/Ycf62 family; hypothetical protein 10335..11612 Streptococcus pneumoniae R6 933448 NP_357605.1 CDS hgt NC_003098.1 11616 12158 D Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 11616..12158 Streptococcus pneumoniae R6 933767 NP_357606.1 CDS ftsH NC_003098.1 12174 14132 D cell division protein FtsH 12174..14132 Streptococcus pneumoniae R6 933698 NP_357607.1 CDS comX1 NC_003098.1 14254 14733 D sigma factor; competence-specific global transcription modulator 14254..14733 Streptococcus pneumoniae R6 933686 NP_357608.1 CDS transposase_A NC_003098.1 20207 20554 D transposase 20207..20554 Streptococcus pneumoniae R6 933716 NP_357610.1 CDS transposase_B NC_003098.1 20733 21071 D transposase 20733..21071 Streptococcus pneumoniae R6 932809 NP_357614.1 CDS spr0020 NC_003098.1 22162 22404 D hypothetical protein 22162..22404 Streptococcus pneumoniae R6 932833 NP_357615.1 CDS purA NC_003098.1 22635 23921 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 22635..23921 Streptococcus pneumoniae R6 933413 NP_357616.1 CDS spr0022 NC_003098.1 24122 24589 D cytidine/deoxycytidylate deaminase 24122..24589 Streptococcus pneumoniae R6 933408 NP_357617.1 CDS dut NC_003098.1 24776 25219 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 24776..25219 Streptococcus pneumoniae R6 933917 NP_357618.1 CDS spr0024 NC_003098.1 25158 25736 D Similar to phosphoglycerate mutase; hypothetical protein 25158..25736 Streptococcus pneumoniae R6 933009 NP_357619.1 CDS radA NC_003098.1 25849 27111 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 25849..27111 Streptococcus pneumoniae R6 933443 NP_357620.1 CDS spr0026 NC_003098.1 27115 27681 D hypothetical protein 27115..27681 Streptococcus pneumoniae R6 933190 NP_357621.1 CDS spr0027 NC_003098.1 27706 28365 D hypothetical protein 27706..28365 Streptococcus pneumoniae R6 933470 NP_357622.1 CDS prsA NC_003098.1 28583 29602 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 28583..29602 Streptococcus pneumoniae R6 932853 NP_357624.1 CDS spr0030 NC_003098.1 30143 30481 R hypothetical protein complement(30143..30481) Streptococcus pneumoniae R6 933421 NP_357625.1 CDS spr0031 NC_003098.1 30700 31053 R hypothetical protein complement(30700..31053) Streptococcus pneumoniae R6 933179 NP_357626.1 CDS polA NC_003098.1 31306 33939 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 31306..33939 Streptococcus pneumoniae R6 933214 NP_357627.1 CDS spr0033 NC_003098.1 34024 34461 D hypothetical protein 34024..34461 Streptococcus pneumoniae R6 933816 NP_357628.1 CDS spr0034 NC_003098.1 34652 35674 R hypothetical protein complement(34652..35674) Streptococcus pneumoniae R6 933827 NP_357629.1 CDS aspC NC_003098.1 35811 36980 D catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 35811..36980 Streptococcus pneumoniae R6 932812 NP_357630.1 CDS recO NC_003098.1 36977 37747 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 36977..37747 Streptococcus pneumoniae R6 933442 NP_357631.1 CDS plsX NC_003098.1 37744 38736 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 37744..38736 Streptococcus pneumoniae R6 932937 NP_357632.1 CDS acpP NC_003098.1 38742 38975 D acyl carrier protein 38742..38975 Streptococcus pneumoniae R6 933946 NP_357634.1 CDS thmA NC_003098.1 39514 39744 D amphipathic pore-forming protein 39514..39744 Streptococcus pneumoniae R6 932910 NP_357635.1 CDS IS1167 NC_003098.1 40224 40991 R transposase complement(40224..40991) Streptococcus pneumoniae R6 933120 NP_357636.1 CDS IS1167 NC_003098.1 40982 41500 R transposase complement(40982..41500) Streptococcus pneumoniae R6 933460 NP_357637.1 CDS comA NC_003098.1 41902 44055 D Competence induced protein ComA, with ComB is responsible for secretion of CSP; competence factor transporting ATP-binding protein/permease ComA 41902..44055 Streptococcus pneumoniae R6 933354 NP_357638.1 CDS comB NC_003098.1 44068 45417 D Competence induced protein ComB, with ComA is responsible for secretion of CSP; competence factor transport protein ComB 44068..45417 Streptococcus pneumoniae R6 933217 NP_357639.1 CDS purC NC_003098.1 45545 46294 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 45545..46294 Streptococcus pneumoniae R6 933370 NP_357640.1 CDS purL NC_003098.1 46493 50221 D phosphoribosylformylglycinamidine synthase 46493..50221 Streptococcus pneumoniae R6 933136 NP_357641.1 CDS purF NC_003098.1 50314 51756 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 50314..51756 Streptococcus pneumoniae R6 933435 NP_357642.1 CDS purM NC_003098.1 51793 52815 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 51793..52815 Streptococcus pneumoniae R6 933451 NP_357643.1 CDS purN NC_003098.1 52812 53357 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 52812..53357 Streptococcus pneumoniae R6 933927 NP_357644.1 CDS vanZ NC_003098.1 53441 53950 D VanZ protein 53441..53950 Streptococcus pneumoniae R6 933039 NP_357645.1 CDS purH NC_003098.1 53954 55522 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 53954..55522 Streptococcus pneumoniae R6 933467 NP_357646.1 CDS purD NC_003098.1 55644 56906 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 55644..56906 Streptococcus pneumoniae R6 933188 YP_008719798.1 CDS spr0052a NC_003098.1 56979 57146 D hypothetical protein 56979..57146 Streptococcus pneumoniae R6 17374503 NP_357647.1 CDS purE NC_003098.1 57276 57797 D Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit 57276..57797 Streptococcus pneumoniae R6 933469 NP_357648.1 CDS purK NC_003098.1 57724 58875 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 57724..58875 Streptococcus pneumoniae R6 933386 NP_357649.1 CDS spr0055 NC_003098.1 58885 59112 D hypothetical protein 58885..59112 Streptococcus pneumoniae R6 933457 NP_357650.1 CDS purB NC_003098.1 59175 60473 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 59175..60473 Streptococcus pneumoniae R6 933426 NP_357651.1 CDS strH NC_003098.1 60528 64466 R beta-N-acetylhexosaminidase complement(60528..64466) Streptococcus pneumoniae R6 933411 NP_357652.1 CDS spr0058 NC_003098.1 64781 65539 R Similar to transcriptional regulator (GntR family); hypothetical protein complement(64781..65539) Streptococcus pneumoniae R6 933173 NP_357653.1 CDS bgaC NC_003098.1 65845 67632 D beta-galactosidase 3 65845..67632 Streptococcus pneumoniae R6 934033 NP_357654.1 CDS PTS-EIIB NC_003098.1 67629 68105 D PTS system transporter subunit IIB 67629..68105 Streptococcus pneumoniae R6 933462 NP_357655.1 CDS PTS-EIIC NC_003098.1 68133 69038 D PTS system transporter subunit IIC 68133..69038 Streptococcus pneumoniae R6 933468 NP_357656.1 CDS PTS-EIID NC_003098.1 69010 69840 D PTS system transporter subunit IID 69010..69840 Streptococcus pneumoniae R6 933330 NP_357657.1 CDS PTS-EII NC_003098.1 69847 70251 D PTS system transporter subunit IIA 69847..70251 Streptococcus pneumoniae R6 932847 NP_357658.1 CDS agaS NC_003098.1 70549 71715 D sugar isomerase domain-containing protein 70549..71715 Streptococcus pneumoniae R6 932790 NP_357659.1 CDS galM NC_003098.1 71831 72868 D aldose 1-epimerase 71831..72868 Streptococcus pneumoniae R6 932955 NP_357660.1 CDS spr0066 NC_003098.1 73075 73929 D hypothetical protein 73075..73929 Streptococcus pneumoniae R6 932795 NP_357661.1 CDS spr0067 NC_003098.1 74079 74336 D hypothetical protein 74079..74336 Streptococcus pneumoniae R6 932792 NP_357662.1 CDS spr0068 NC_003098.1 75311 76075 D Similar to uridine phosphorylase; hypothetical protein 75311..76075 Streptococcus pneumoniae R6 932794 NP_357663.1 CDS spr0069 NC_003098.1 76547 76705 D hypothetical protein 76547..76705 Streptococcus pneumoniae R6 934052 NP_357664.1 CDS trkH NC_003098.1 76686 78065 D Trk transporter membrane-spanning protein 76686..78065 Streptococcus pneumoniae R6 932801 NP_357665.1 CDS trkA NC_003098.1 78058 78744 D Trk transporter NAD+ binding protein 78058..78744 Streptococcus pneumoniae R6 932799 NP_357669.1 CDS spr0075 NC_003098.1 80186 83671 D Similar to cell wall-associated serine proteinase; cell wall surface anchor family protein 80186..83671 Streptococcus pneumoniae R6 932818 NP_357670.1 CDS rr08 NC_003098.1 83838 84536 D DNA-binding response regulator 83838..84536 Streptococcus pneumoniae R6 932813 NP_357671.1 CDS hk08 NC_003098.1 84533 85585 D sensor histidine kinase 84533..85585 Streptococcus pneumoniae R6 932804 NP_357672.1 CDS rpsD NC_003098.1 85780 86391 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 85780..86391 Streptococcus pneumoniae R6 932816 NP_357673.1 CDS transposase_A NC_003098.1 86559 86735 D degenerative transposase 86559..86735 Streptococcus pneumoniae R6 932823 NP_357674.1 CDS spr0080 NC_003098.1 87044 87313 D hypothetical protein 87044..87313 Streptococcus pneumoniae R6 932834 NP_357675.1 CDS ABC-MSP NC_003098.1 87777 88736 D ABC transporter permease 87777..88736 Streptococcus pneumoniae R6 932828 NP_357676.1 CDS ABC-MSP NC_003098.1 88750 89673 D ABC transporter permease 88750..89673 Streptococcus pneumoniae R6 932824 NP_357677.1 CDS ABC-SBP NC_003098.1 89862 91406 D ABC transporter substrate-binding protein 89862..91406 Streptococcus pneumoniae R6 932838 NP_357678.1 CDS spr0084 NC_003098.1 91678 92664 D hypothetical protein 91678..92664 Streptococcus pneumoniae R6 932820 NP_357679.1 CDS spr0085 NC_003098.1 92633 93646 D hypothetical protein 92633..93646 Streptococcus pneumoniae R6 932845 NP_357680.1 CDS spr0086 NC_003098.1 93718 94782 R hypothetical protein complement(93718..94782) Streptococcus pneumoniae R6 932843 NP_357681.1 CDS spr0087 NC_003098.1 94845 95807 R hypothetical protein complement(94845..95807) Streptococcus pneumoniae R6 932839 NP_357682.1 CDS spr0088 NC_003098.1 95749 96342 R hypothetical protein complement(95749..96342) Streptococcus pneumoniae R6 932844 NP_357683.1 CDS spr0089 NC_003098.1 96329 96655 R hypothetical protein complement(96329..96655) Streptococcus pneumoniae R6 932854 NP_357684.1 CDS spr0090 NC_003098.1 96794 97960 R transporter complement(96794..97960) Streptococcus pneumoniae R6 932858 NP_357685.1 CDS spr0091 NC_003098.1 98018 99175 D sugar transferase related protein; hypothetical protein 98018..99175 Streptococcus pneumoniae R6 932836 NP_357686.1 CDS capD NC_003098.1 99217 101067 D capsule polysaccharide biosynthesis protein CapD 99217..101067 Streptococcus pneumoniae R6 932856 NP_357687.1 CDS gph NC_003098.1 101463 102095 R phosphoglycolate phosphatase complement(101463..102095) Streptococcus pneumoniae R6 932857 NP_357688.1 CDS sdaA NC_003098.1 102117 102989 R L-serine dehydratase subunit alpha complement(102117..102989) Streptococcus pneumoniae R6 932859 NP_357689.1 CDS sdaB NC_003098.1 102998 103669 R L-serine dehydratase subunit beta complement(102998..103669) Streptococcus pneumoniae R6 932851 NP_357690.1 CDS spr0096 NC_003098.1 103911 104414 D LysM domain-containing protein 103911..104414 Streptococcus pneumoniae R6 932867 NP_357692.1 CDS spr0098 NC_003098.1 105242 105490 D bacteriocin 105242..105490 Streptococcus pneumoniae R6 932864 NP_357693.1 CDS ABC-MSP NC_003098.1 105545 107653 D amino acid ABC transporter permease 105545..107653 Streptococcus pneumoniae R6 932866 NP_357694.1 CDS ABC-NBD NC_003098.1 107650 108291 D amino acid ABC transporter ATP-binding protein 107650..108291 Streptococcus pneumoniae R6 932876 NP_357695.1 CDS ABC-SBP NC_003098.1 108506 109303 D amino acid ABC transporter substrate-binding protein 108506..109303 Streptococcus pneumoniae R6 932861 NP_357696.1 CDS argG NC_003098.1 109269 110516 D catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 109269..110516 Streptococcus pneumoniae R6 932865 NP_357697.1 CDS argH NC_003098.1 110545 111936 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 110545..111936 Streptococcus pneumoniae R6 932888 NP_357698.1 CDS spr0104 NC_003098.1 112225 113124 R hypothetical protein complement(112225..113124) Streptococcus pneumoniae R6 932874 NP_357700.1 CDS spr0106 NC_003098.1 113839 115773 D Similar to competence factor transporting ATP-binding/permease ComA; ABC transporter permease/ATP-binding protein 113839..115773 Streptococcus pneumoniae R6 932887 NP_357701.1 CDS spr0107 NC_003098.1 115766 116233 D hypothetical protein 115766..116233 Streptococcus pneumoniae R6 932869 NP_357702.1 CDS spr0108 NC_003098.1 116230 117582 D Similar to ComB protein; hypothetical protein 116230..117582 Streptococcus pneumoniae R6 932889 NP_357703.1 CDS spr0109 NC_003098.1 117728 118108 D hypothetical protein 117728..118108 Streptococcus pneumoniae R6 932896 NP_357704.1 CDS spr0110 NC_003098.1 118611 118931 R hypothetical protein complement(118611..118931) Streptococcus pneumoniae R6 932885 NP_357705.1 CDS spr0111 NC_003098.1 119688 120059 D hypothetical protein 119688..120059 Streptococcus pneumoniae R6 932883 NP_357706.1 CDS spr0112 NC_003098.1 120067 120279 D hypothetical protein 120067..120279 Streptococcus pneumoniae R6 932895 NP_357707.1 CDS spr0113 NC_003098.1 121084 122142 D hypothetical protein 121084..122142 Streptococcus pneumoniae R6 932879 NP_357708.1 CDS spr0114 NC_003098.1 122441 123433 D hypothetical protein 122441..123433 Streptococcus pneumoniae R6 932880 NP_357709.1 CDS spr0115 NC_003098.1 123810 124184 D hypothetical protein 123810..124184 Streptococcus pneumoniae R6 932891 NP_357710.1 CDS spr0116 NC_003098.1 124191 124373 D hypothetical protein 124191..124373 Streptococcus pneumoniae R6 932892 NP_357711.1 CDS spr0117 NC_003098.1 124392 125294 D hypothetical protein 124392..125294 Streptococcus pneumoniae R6 932893 NP_357712.1 CDS spr0118 NC_003098.1 125317 125703 D hypothetical protein 125317..125703 Streptococcus pneumoniae R6 932899 NP_357713.1 CDS spr0119 NC_003098.1 125670 126428 D hypothetical protein 125670..126428 Streptococcus pneumoniae R6 932890 YP_008719799.1 CDS spr0119a NC_003098.1 126907 127104 D hypothetical protein 126907..127104 Streptococcus pneumoniae R6 17374504 NP_357714.1 CDS spr0120 NC_003098.1 127503 127802 D hypothetical protein 127503..127802 Streptococcus pneumoniae R6 932897 NP_357715.1 CDS pspA NC_003098.1 128356 130215 D surface protein pspA 128356..130215 Streptococcus pneumoniae R6 932894 NP_357716.1 CDS mnmA NC_003098.1 130562 131737 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 130562..131737 Streptococcus pneumoniae R6 932900 NP_357717.1 CDS spr0123 NC_003098.1 131851 132333 D Similar to MutT protein; MutT/nudix family protein 131851..132333 Streptococcus pneumoniae R6 932906 NP_357718.1 CDS gidA NC_003098.1 132343 134256 D GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 132343..134256 Streptococcus pneumoniae R6 932898 NP_357719.1 CDS spr0125 NC_003098.1 134636 136468 R Predicted hydrolase of the metallo-beta-lactamase superfamily; hypothetical protein complement(134636..136468) Streptococcus pneumoniae R6 934629 NP_357720.1 CDS spr0126 NC_003098.1 136317 136550 R hypothetical protein complement(136317..136550) Streptococcus pneumoniae R6 932901 NP_357721.1 CDS orf51 NC_003098.1 137368 137520 R Induced during competence; hypothetical protein complement(137368..137520) Streptococcus pneumoniae R6 934632 NP_357722.1 CDS spr0128 NC_003098.1 137522 137707 R hypothetical protein complement(137522..137707) Streptococcus pneumoniae R6 934875 NP_357723.1 CDS spr0129 NC_003098.1 137885 138568 D hypothetical protein 137885..138568 Streptococcus pneumoniae R6 932905 NP_357724.1 CDS rimI NC_003098.1 138565 139002 D ribosomal protein alanine acetyltransferase 138565..139002 Streptococcus pneumoniae R6 932904 NP_357725.1 CDS gcp NC_003098.1 138992 140002 D in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 138992..140002 Streptococcus pneumoniae R6 934879 NP_357728.1 CDS transposase_A NC_003098.1 142041 142307 R degenerative transposase complement(142041..142307) Streptococcus pneumoniae R6 934892 NP_357729.1 CDS epsG NC_003098.1 142595 143809 D exopolysaccharide (EPS) synthesis glycosyltransferase 142595..143809 Streptococcus pneumoniae R6 934883 NP_357730.1 CDS glycosyltransferase NC_003098.1 143802 144755 D glycosyl transferase 143802..144755 Streptococcus pneumoniae R6 934876 NP_357731.1 CDS ABC-NP NC_003098.1 144765 146381 D ABC transporter ATP-binding protein 144765..146381 Streptococcus pneumoniae R6 934878 NP_357732.1 CDS spr0138 NC_003098.1 147164 147919 D hypothetical protein 147164..147919 Streptococcus pneumoniae R6 934887 NP_357733.1 CDS ugd NC_003098.1 147932 149104 D UDP-glucose dehydrogenase 147932..149104 Streptococcus pneumoniae R6 934890 NP_357734.1 CDS mutR NC_003098.1 149499 150362 D transcriptional regulator 149499..150362 Streptococcus pneumoniae R6 934880 NP_357735.1 CDS spr0141 NC_003098.1 150653 150886 D hypothetical protein 150653..150886 Streptococcus pneumoniae R6 934894 NP_357736.1 CDS spr0142 NC_003098.1 150908 151585 D hypothetical protein 150908..151585 Streptococcus pneumoniae R6 934881 NP_357737.1 CDS spr0143 NC_003098.1 151597 152262 D hypothetical protein 151597..152262 Streptococcus pneumoniae R6 934885 NP_357738.1 CDS spr0144 NC_003098.1 152331 153560 D hypothetical protein 152331..153560 Streptococcus pneumoniae R6 934888 NP_357739.1 CDS spr0145 NC_003098.1 153770 154366 D hypothetical protein 153770..154366 Streptococcus pneumoniae R6 934882 NP_357740.1 CDS ABC-SBP NC_003098.1 154470 155300 D amino acid ABC transporter substrate-binding protein 154470..155300 Streptococcus pneumoniae R6 934902 NP_357741.1 CDS ABC-SBP NC_003098.1 155454 156308 D lipoprotein 155454..156308 Streptococcus pneumoniae R6 934877 NP_357742.1 CDS dapE NC_003098.1 156408 157781 D hypothetical protein 156408..157781 Streptococcus pneumoniae R6 934884 NP_357743.1 CDS ABC-NBD NC_003098.1 157774 158835 D ABC transporter ATP-binding protein 157774..158835 Streptococcus pneumoniae R6 934901 NP_357744.1 CDS ABC-MSD NC_003098.1 158837 159529 D ABC transporter permease 158837..159529 Streptococcus pneumoniae R6 934898 NP_357745.1 CDS spr0151 NC_003098.1 159559 160128 R hypothetical protein complement(159559..160128) Streptococcus pneumoniae R6 934904 NP_357746.1 CDS spr0152 NC_003098.1 160263 160877 D hypothetical protein 160263..160877 Streptococcus pneumoniae R6 934895 NP_357747.2 CDS hk07 NC_003098.1 160855 162525 D histidine kinase 160855..162525 Streptococcus pneumoniae R6 934900 NP_357748.1 CDS rr07 NC_003098.1 162537 163823 D DNA-binding response regulator 162537..163823 Streptococcus pneumoniae R6 934903 NP_357749.1 CDS spr0155 NC_003098.1 163827 164408 D hypothetical protein 163827..164408 Streptococcus pneumoniae R6 934897 NP_357750.1 CDS spr0156 NC_003098.1 164354 164956 D has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; flavoprotein NrdI 164354..164956 Streptococcus pneumoniae R6 934899 NP_357751.1 CDS spr0157 NC_003098.1 165249 166511 R hypothetical protein complement(165249..166511) Streptococcus pneumoniae R6 934021 NP_357752.1 CDS spr0158 NC_003098.1 166821 167279 R hypothetical protein complement(166821..167279) Streptococcus pneumoniae R6 932902 NP_357753.1 CDS spr0159 NC_003098.1 167276 167797 R Similar to autolysin response regulator in Bacillus subtilis; hypothetical protein complement(167276..167797) Streptococcus pneumoniae R6 934023 NP_357754.1 CDS mutL NC_003098.1 168072 170021 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 168072..170021 Streptococcus pneumoniae R6 934896 NP_357755.1 CDS ribH NC_003098.1 170346 170813 R RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase complement(170346..170813) Streptococcus pneumoniae R6 933803 NP_357756.1 CDS ribA NC_003098.1 170814 172019 R 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(170814..172019) Streptococcus pneumoniae R6 934025 NP_357757.1 CDS ribC NC_003098.1 172039 172674 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(172039..172674) Streptococcus pneumoniae R6 933132 NP_357758.1 CDS ribD NC_003098.1 172659 173759 R riboflavin biosynthesis protein RibD complement(172659..173759) Streptococcus pneumoniae R6 933106 NP_357759.1 CDS ruvA NC_003098.1 174163 174756 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 174163..174756 Streptococcus pneumoniae R6 933035 NP_357760.1 CDS tag NC_003098.1 174766 175329 D DNA-3-methyladenine glycosylase I 174766..175329 Streptococcus pneumoniae R6 933894 NP_357761.1 CDS spr0167 NC_003098.1 175326 176003 D hypothetical protein 175326..176003 Streptococcus pneumoniae R6 932875 NP_357762.1 CDS spr0168 NC_003098.1 176158 177189 R MccF-like proteins; MccC family protein complement(176158..177189) Streptococcus pneumoniae R6 933807 NP_357763.1 CDS spr0169 NC_003098.1 177444 178148 R hypothetical protein complement(177444..178148) Streptococcus pneumoniae R6 933844 NP_357764.1 CDS corA NC_003098.1 178139 179083 R magnesium/cobalt transporter CorA complement(178139..179083) Streptococcus pneumoniae R6 933183 NP_357765.1 CDS uvrA NC_003098.1 179215 182046 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 179215..182046 Streptococcus pneumoniae R6 933838 NP_357766.1 CDS pepP NC_003098.1 182039 183100 D peptidase M24 family protein 182039..183100 Streptococcus pneumoniae R6 933987 NP_357767.1 CDS spxA NC_003098.1 183232 183630 D the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 183232..183630 Streptococcus pneumoniae R6 933168 NP_357768.1 CDS spr0174 NC_003098.1 183696 184265 D hypothetical protein 183696..184265 Streptococcus pneumoniae R6 933777 NP_357769.1 CDS spr0175 NC_003098.1 184352 184618 D hypothetical protein 184352..184618 Streptococcus pneumoniae R6 933164 NP_357770.1 CDS spr0176 NC_003098.1 184622 185041 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 184622..185041 Streptococcus pneumoniae R6 933212 NP_357771.1 CDS spr0177 NC_003098.1 185057 185362 D hypothetical protein 185057..185362 Streptococcus pneumoniae R6 933178 NP_357772.1 CDS folC NC_003098.1 185813 187069 D dihydrofolate:folylpolyglutamate synthetase 185813..187069 Streptococcus pneumoniae R6 933972 NP_357773.1 CDS spr0179 NC_003098.1 187066 187584 D hypothetical protein 187066..187584 Streptococcus pneumoniae R6 932873 NP_357774.1 CDS cls NC_003098.1 187730 189262 D cardiolipin synthetase 187730..189262 Streptococcus pneumoniae R6 933187 NP_357775.1 CDS orf47 NC_003098.1 189340 189483 D Induced during competence; hypothetical protein 189340..189483 Streptococcus pneumoniae R6 933180 NP_357776.1 CDS spr0182 NC_003098.1 189502 191058 D Competence-induced protein Ccs4; competence-induced protein Ccs4 189502..191058 Streptococcus pneumoniae R6 932988 NP_357777.1 CDS nrdD NC_003098.1 191172 193385 D Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 191172..193385 Streptococcus pneumoniae R6 932922 NP_357778.1 CDS spr0184 NC_003098.1 193581 194087 D Similar to histone acetyltransferase HPA2 and related acetyltransferases; hypothetical protein 193581..194087 Streptococcus pneumoniae R6 932982 NP_357779.1 CDS nrdG NC_003098.1 194080 194670 D anaerobic ribonucleoside-triphosphate reductase activating protein 194080..194670 Streptococcus pneumoniae R6 932981 NP_357780.1 CDS spr0186 NC_003098.1 194667 195284 D hypothetical protein 194667..195284 Streptococcus pneumoniae R6 933102 NP_357781.1 CDS rpsJ NC_003098.1 195551 195859 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 195551..195859 Streptococcus pneumoniae R6 932811 NP_357782.1 CDS rplC NC_003098.1 196076 196702 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 196076..196702 Streptococcus pneumoniae R6 932979 NP_357783.1 CDS rplD NC_003098.1 196727 197350 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 196727..197350 Streptococcus pneumoniae R6 933169 NP_357784.1 CDS rplW NC_003098.1 197350 197646 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 197350..197646 Streptococcus pneumoniae R6 932965 NP_357785.1 CDS rplB NC_003098.1 197664 198497 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 197664..198497 Streptococcus pneumoniae R6 933760 NP_357786.1 CDS rpsS NC_003098.1 198601 198882 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 198601..198882 Streptococcus pneumoniae R6 932870 NP_357788.1 CDS rplV NC_003098.1 198894 199238 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 198894..199238 Streptococcus pneumoniae R6 932936 NP_357789.1 CDS rpsC NC_003098.1 199251 199904 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 199251..199904 Streptococcus pneumoniae R6 933129 NP_357790.1 CDS rplP NC_003098.1 199908 200321 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 199908..200321 Streptococcus pneumoniae R6 933103 NP_357791.1 CDS rpmC NC_003098.1 200331 200537 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 200331..200537 Streptococcus pneumoniae R6 933478 NP_357792.1 CDS rpsQ NC_003098.1 200562 200822 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 200562..200822 Streptococcus pneumoniae R6 932999 NP_357793.1 CDS rplN NC_003098.1 200848 201216 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 200848..201216 Streptococcus pneumoniae R6 933923 NP_357794.1 CDS rplX NC_003098.1 201294 201599 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 201294..201599 Streptococcus pneumoniae R6 933260 NP_357795.1 CDS rplE NC_003098.1 201623 202165 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 201623..202165 Streptococcus pneumoniae R6 932791 NP_357796.1 CDS rpsN NC_003098.1 202183 202452 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 202183..202452 Streptococcus pneumoniae R6 933061 NP_357797.1 CDS rpsH NC_003098.1 202737 203135 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 202737..203135 Streptococcus pneumoniae R6 933398 NP_357798.1 CDS rplF NC_003098.1 203327 203863 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 203327..203863 Streptococcus pneumoniae R6 933505 NP_357799.1 CDS rplR NC_003098.1 203947 204303 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 203947..204303 Streptococcus pneumoniae R6 933766 NP_357800.1 CDS rpsE NC_003098.1 204321 204815 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 204321..204815 Streptococcus pneumoniae R6 933812 NP_357801.1 CDS rpmD NC_003098.1 204829 205011 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 204829..205011 Streptococcus pneumoniae R6 933890 NP_357802.1 CDS rplO NC_003098.1 205156 205596 D late assembly protein; 50S ribosomal protein L15 205156..205596 Streptococcus pneumoniae R6 933940 NP_357803.1 CDS secY NC_003098.1 205609 206919 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 205609..206919 Streptococcus pneumoniae R6 933437 NP_357804.1 CDS adk NC_003098.1 207070 207708 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 207070..207708 Streptococcus pneumoniae R6 933789 NP_357805.2 CDS infA NC_003098.1 207825 208043 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 207825..208043 Streptococcus pneumoniae R6 932927 NP_357806.1 CDS rpmJ NC_003098.1 208068 208184 D smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 208068..208184 Streptococcus pneumoniae R6 933957 NP_357807.1 CDS rpsM NC_003098.1 208202 208567 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 208202..208567 Streptococcus pneumoniae R6 933973 NP_357808.1 CDS rpsK NC_003098.1 208585 208968 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 208585..208968 Streptococcus pneumoniae R6 933403 NP_357809.1 CDS rpoA NC_003098.1 209011 209946 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 209011..209946 Streptococcus pneumoniae R6 933822 NP_357810.1 CDS rplQ NC_003098.1 209958 210344 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 209958..210344 Streptococcus pneumoniae R6 933143 NP_357811.2 CDS spr0217 NC_003098.1 210609 210875 D ACT domain-containing protein; hypothetical protein 210609..210875 Streptococcus pneumoniae R6 933047 NP_357812.1 CDS spr0218 NC_003098.1 210885 212222 D hypothetical protein 210885..212222 Streptococcus pneumoniae R6 933558 NP_357813.1 CDS gpmB NC_003098.1 212409 213158 D phosphoglycerate mutase 212409..213158 Streptococcus pneumoniae R6 933096 NP_357814.1 CDS ABC-MSP NC_003098.1 213261 214295 R iron ABC transporter permease complement(213261..214295) Streptococcus pneumoniae R6 933873 NP_357815.1 CDS ABC-MSP NC_003098.1 214280 214906 R iron ABC transporter permease complement(214280..214906) Streptococcus pneumoniae R6 933823 NP_357816.1 CDS ABC-NBD NC_003098.1 214896 215987 R ABC transporter ATP-binding protein complement(214896..215987) Streptococcus pneumoniae R6 933981 NP_357819.1 CDS spr0225 NC_003098.1 217339 217536 R hypothetical protein complement(217339..217536) Streptococcus pneumoniae R6 932975 NP_357820.1 CDS pflE NC_003098.1 217611 218387 R pyruvate formate-lyase 3 complement(217611..218387) Streptococcus pneumoniae R6 933787 NP_357821.1 CDS deoR NC_003098.1 218461 219255 D DEOR-type transcriptional regulator 218461..219255 Streptococcus pneumoniae R6 933802 NP_357822.1 CDS spr0228 NC_003098.1 219268 220248 D Resembles sorbitol operon regulator; hypothetical protein 219268..220248 Streptococcus pneumoniae R6 932868 NP_357823.1 CDS PTS-EIIA NC_003098.1 220443 220763 D PTS system transporter subunit IIA 220443..220763 Streptococcus pneumoniae R6 933017 NP_357824.1 CDS PTS-EIIB NC_003098.1 220809 221117 D PTS system transporter subunit IIB 220809..221117 Streptococcus pneumoniae R6 933950 NP_357825.1 CDS PTS-EIIC NC_003098.1 221110 222432 D PTS system transporter subunit IIC 221110..222432 Streptococcus pneumoniae R6 934634 NP_357826.1 CDS pflF NC_003098.1 222574 225021 D formate acetyltransferase 3 222574..225021 Streptococcus pneumoniae R6 932996 NP_357827.1 CDS talC NC_003098.1 225040 225708 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 225040..225708 Streptococcus pneumoniae R6 933429 NP_357828.1 CDS gldA NC_003098.1 225726 226814 D forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 225726..226814 Streptococcus pneumoniae R6 934143 NP_357829.1 CDS leuS NC_003098.1 227269 229770 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 227269..229770 Streptococcus pneumoniae R6 934057 NP_357830.1 CDS spr0236 NC_003098.1 229964 230659 D Similar to acetyltransferases, including N-acetylases of ribosomal proteins; hypothetical protein 229964..230659 Streptococcus pneumoniae R6 933481 NP_357831.1 CDS spr0237 NC_003098.1 230671 231087 D Similar to histone acetyltransferase HPA2 and related acetyltransferases; hypothetical protein 230671..231087 Streptococcus pneumoniae R6 934635 NP_357832.1 CDS ruvB NC_003098.1 232128 233126 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 232128..233126 Streptococcus pneumoniae R6 934147 NP_357833.1 CDS spr0239 NC_003098.1 233107 233679 D hypothetical protein 233107..233679 Streptococcus pneumoniae R6 933735 NP_357834.1 CDS uppS NC_003098.1 233892 234668 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 233892..234668 Streptococcus pneumoniae R6 934063 NP_357835.1 CDS cdsA NC_003098.1 234677 235480 D phosphatidate cytidylyltransferase 234677..235480 Streptococcus pneumoniae R6 934160 NP_357836.1 CDS eep NC_003098.1 235502 236761 D determinant for enhanced expression of pheromone 235502..236761 Streptococcus pneumoniae R6 933841 NP_357837.1 CDS proS NC_003098.1 236774 238627 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 236774..238627 Streptococcus pneumoniae R6 933853 NP_357838.1 CDS bglA NC_003098.1 238727 240106 D 6-phospho-beta-glucosidase 238727..240106 Streptococcus pneumoniae R6 932970 NP_357839.1 CDS glmS NC_003098.1 240298 242106 D Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 240298..242106 Streptococcus pneumoniae R6 932810 NP_357840.1 CDS spr0246 NC_003098.1 242225 243274 D Similar to coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and and related flavin-dependent oxidoreductases; hypothetical protein 242225..243274 Streptococcus pneumoniae R6 933939 NP_357841.1 CDS pulA NC_003098.1 243374 247144 R alkaline amylopullulanase complement(243374..247144) Streptococcus pneumoniae R6 933840 NP_357842.1 CDS rpsL NC_003098.1 247561 247974 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 247561..247974 Streptococcus pneumoniae R6 934814 NP_357843.1 CDS rpsG NC_003098.1 247994 248464 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 247994..248464 Streptococcus pneumoniae R6 933759 NP_357844.1 CDS fusA NC_003098.1 248889 250970 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 248889..250970 Streptococcus pneumoniae R6 933055 NP_357845.1 CDS polC NC_003098.1 251074 255465 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 251074..255465 Streptococcus pneumoniae R6 934637 NP_357846.1 CDS spr0252 NC_003098.1 255567 255830 D hypothetical protein 255567..255830 Streptococcus pneumoniae R6 933022 NP_357847.1 CDS spr0253 NC_003098.1 255823 256101 D hypothetical protein 255823..256101 Streptococcus pneumoniae R6 932971 NP_357848.1 CDS pepS NC_003098.1 256296 257537 D aminopeptidase 256296..257537 Streptococcus pneumoniae R6 934836 NP_357849.1 CDS spr0255 NC_003098.1 257547 257777 D hypothetical protein 257547..257777 Streptococcus pneumoniae R6 934172 NP_357850.1 CDS rsuA NC_003098.1 258090 258812 D ribosomal small subunit pseudouridine synthase A 258090..258812 Streptococcus pneumoniae R6 933942 NP_357851.1 CDS spr0257 NC_003098.1 258893 259057 D hypothetical protein 258893..259057 Streptococcus pneumoniae R6 934764 NP_357852.1 CDS pepC NC_003098.1 259029 260363 D aminopeptidase 259029..260363 Streptococcus pneumoniae R6 934645 NP_357853.1 CDS manN NC_003098.1 260419 261330 R PTS system mannose-specific transporter subunit EIID complement(260419..261330) Streptococcus pneumoniae R6 934837 NP_357854.1 CDS manM NC_003098.1 261354 262157 R PTS system mannose-specific transporter subunit IIC complement(261354..262157) Streptococcus pneumoniae R6 934638 NP_357855.1 CDS manL NC_003098.1 262185 263183 R PTS system mannose-specific transporter subunit IIAB complement(262185..263183) Streptococcus pneumoniae R6 934647 NP_357856.1 CDS adhP NC_003098.1 263358 264377 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(263358..264377) Streptococcus pneumoniae R6 934639 NP_357857.1 CDS spr0263 NC_003098.1 264716 265528 R Cof family protein complement(264716..265528) Streptococcus pneumoniae R6 934654 NP_357858.1 CDS spr0264 NC_003098.1 265664 267136 D xanthine/uracil permease 265664..267136 Streptococcus pneumoniae R6 934650 NP_357859.1 CDS spr0265 NC_003098.1 267187 267897 D hypothetical protein 267187..267897 Streptococcus pneumoniae R6 934648 NP_357860.1 CDS sulA NC_003098.1 268022 268966 D dihydropteroate synthase 268022..268966 Streptococcus pneumoniae R6 934662 NP_357861.1 CDS sulB NC_003098.1 268968 270290 D dihydrofolate synthetase 268968..270290 Streptococcus pneumoniae R6 934661 NP_357862.1 CDS folE NC_003098.1 270271 270825 D involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 270271..270825 Streptococcus pneumoniae R6 934652 NP_357863.1 CDS sulD NC_003098.1 270868 271680 D bifunctional folate synthesis protein 270868..271680 Streptococcus pneumoniae R6 934668 NP_357864.1 CDS spr0270 NC_003098.1 271725 272096 R hypothetical protein complement(271725..272096) Streptococcus pneumoniae R6 934659 NP_357865.1 CDS rplM NC_003098.1 272399 272845 D in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 272399..272845 Streptococcus pneumoniae R6 934656 NP_357866.1 CDS rpsI NC_003098.1 272865 273257 D forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 272865..273257 Streptococcus pneumoniae R6 934684 NP_357869.1 CDS spr0275 NC_003098.1 273944 274309 D hypothetical protein 273944..274309 Streptococcus pneumoniae R6 934666 NP_357870.1 CDS celA NC_003098.1 274499 275935 D converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 274499..275935 Streptococcus pneumoniae R6 934676 NP_357871.1 CDS spr0277 NC_003098.1 275987 276226 D hypothetical protein 275987..276226 Streptococcus pneumoniae R6 934690 NP_357872.2 CDS celB NC_003098.1 276356 276670 D required for cellobiose uptake and metabolism; PTS system cellobiose transporter subunit IIB 276356..276670 Streptococcus pneumoniae R6 934677 NP_357873.1 CDS bglG NC_003098.1 276788 278767 D BigG family transcription antiterminator 276788..278767 Streptococcus pneumoniae R6 934694 NP_357874.1 CDS celC NC_003098.1 278777 279091 D required for cellobiose uptake and metabolism; PTS system cellobiose transporter subunit IIA 278777..279091 Streptococcus pneumoniae R6 934696 NP_357875.1 CDS spr0281 NC_003098.1 279110 279616 D hypothetical protein 279110..279616 Streptococcus pneumoniae R6 934682 NP_357876.1 CDS celD NC_003098.1 279696 281042 D required for cellobiose uptake and metabolism; PTS system cellobiose transporter subunit IIC 279696..281042 Streptococcus pneumoniae R6 934687 NP_357877.1 CDS spr0283 NC_003098.1 281424 281600 D hypothetical protein 281424..281600 Streptococcus pneumoniae R6 934700 NP_357878.1 CDS xylS NC_003098.1 282002 284215 D Alpha-xylosidase 282002..284215 Streptococcus pneumoniae R6 934686 NP_357879.1 CDS basA NC_003098.1 284437 284913 R glutathione peroxidase complement(284437..284913) Streptococcus pneumoniae R6 934692 NP_357880.1 CDS hysA NC_003098.1 285103 288339 D hyaluronate lyase 285103..288339 Streptococcus pneumoniae R6 934705 NP_357881.1 CDS kdgA NC_003098.1 289483 290112 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(289483..290112) Streptococcus pneumoniae R6 934703 NP_357882.1 CDS kdgK NC_003098.1 290122 291123 R 2-keto-3-deoxygluconate kinase complement(290122..291123) Streptococcus pneumoniae R6 934712 NP_357883.1 CDS spr0289 NC_003098.1 291154 291795 R hypothetical protein complement(291154..291795) Streptococcus pneumoniae R6 934706 NP_357884.1 CDS gno NC_003098.1 291814 292629 R Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase complement(291814..292629) Streptococcus pneumoniae R6 934713 NP_357885.1 CDS PTS-EII NC_003098.1 292900 293334 D PTS system transporter subunit IIA 292900..293334 Streptococcus pneumoniae R6 934720 NP_357886.1 CDS ugl NC_003098.1 293346 294536 D glucuronyl hydrolase 293346..294536 Streptococcus pneumoniae R6 934711 NP_357887.1 CDS PTS-EII NC_003098.1 294547 295038 D PTS system transporter subunit IIB 294547..295038 Streptococcus pneumoniae R6 934726 NP_357888.1 CDS PTS-EII NC_003098.1 295053 295832 D PTS system transporter subunit IIC 295053..295832 Streptococcus pneumoniae R6 934729 NP_357889.1 CDS PTS-EII NC_003098.1 295819 296637 D PTS system transporter subunit IID 295819..296637 Streptococcus pneumoniae R6 934723 NP_357890.1 CDS spr0296 NC_003098.1 296637 296930 D preprotein translocase, YajC subunit 296637..296930 Streptococcus pneumoniae R6 934717 NP_357891.1 CDS spr0297 NC_003098.1 296952 298853 D hypothetical protein 296952..298853 Streptococcus pneumoniae R6 934735 NP_357892.1 CDS regR NC_003098.1 298847 299914 D GalR family transcription regulator 298847..299914 Streptococcus pneumoniae R6 934722 NP_357894.1 CDS spr0300 NC_003098.1 300360 300602 R hypothetical protein complement(300360..300602) Streptococcus pneumoniae R6 934742 NP_357895.1 CDS yorfE NC_003098.1 300618 300812 R transcriptional regulator complement(300618..300812) Streptococcus pneumoniae R6 934732 NP_357896.1 CDS mraW NC_003098.1 300978 301928 D S-adenosyl-methyltransferase MraW 300978..301928 Streptococcus pneumoniae R6 934733 NP_357897.1 CDS ftsL NC_003098.1 301940 302257 D cell division protein FtsL 301940..302257 Streptococcus pneumoniae R6 934757 NP_357898.1 CDS pbpX NC_003098.1 302261 304513 D penicillin-binding protein 2X 302261..304513 Streptococcus pneumoniae R6 934744 NP_357899.1 CDS mraY NC_003098.1 304515 305495 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 304515..305495 Streptococcus pneumoniae R6 934737 NP_357901.1 CDS clpL NC_003098.1 306052 308157 D ATP-dependent protease ATP-binding subunit 306052..308157 Streptococcus pneumoniae R6 934751 NP_357902.1 CDS luxS NC_003098.1 308453 308935 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(308453..308935) Streptococcus pneumoniae R6 934756 NP_357903.1 CDS spr0309 NC_003098.1 309030 310514 R hypothetical protein complement(309030..310514) Streptococcus pneumoniae R6 934750 NP_357904.1 CDS dexB NC_003098.1 310667 312274 D glucan 1,6-alpha-glucosidase 310667..312274 Streptococcus pneumoniae R6 934759 NP_357905.1 CDS spr0311 NC_003098.1 312433 312606 D hypothetical protein 312433..312606 Streptococcus pneumoniae R6 934763 NP_357908.1 CDS cps2A NC_003098.1 313695 314657 D hypothetical protein 313695..314657 Streptococcus pneumoniae R6 934761 NP_357909.1 CDS cps2H NC_003098.1 314551 315585 D hypothetical protein 314551..315585 Streptococcus pneumoniae R6 934766 NP_357910.1 CDS cps2I NC_003098.1 315715 316872 D hypothetical protein 315715..316872 Streptococcus pneumoniae R6 934782 NP_357911.1 CDS cps2J NC_003098.1 316869 318278 D hypothetical protein 316869..318278 Streptococcus pneumoniae R6 934770 NP_357912.1 CDS cps2K NC_003098.1 318314 319552 D hypothetical protein 318314..319552 Streptococcus pneumoniae R6 934772 NP_357913.1 CDS cps2P NC_003098.1 319581 320186 D hypothetical protein 319581..320186 Streptococcus pneumoniae R6 934780 NP_357914.1 CDS cps2L NC_003098.1 320264 321133 D hypothetical protein 320264..321133 Streptococcus pneumoniae R6 934775 NP_357915.1 CDS cps2M NC_003098.1 321134 321727 D hypothetical protein 321134..321727 Streptococcus pneumoniae R6 934787 NP_357916.1 CDS cpsN NC_003098.1 321740 322789 D dTDP-glucose-4,6-dehydratase 321740..322789 Streptococcus pneumoniae R6 934796 NP_357917.1 CDS cpsO NC_003098.1 322855 323706 D dTDP-L-rhamnose synthase 322855..323706 Streptococcus pneumoniae R6 934778 NP_357919.1 CDS spr0325 NC_003098.1 324231 324680 D hypothetical protein 324231..324680 Streptococcus pneumoniae R6 934802 NP_357920.1 CDS spr0326 NC_003098.1 324751 324909 D hypothetical protein 324751..324909 Streptococcus pneumoniae R6 934785 NP_357921.1 CDS aliA NC_003098.1 325111 327093 D oligopeptide ABC transporter substrate-binding protein 325111..327093 Streptococcus pneumoniae R6 934786 NP_357922.1 CDS spr0328 NC_003098.1 327393 332696 D cell wall surface anchor family protein 327393..332696 Streptococcus pneumoniae R6 934804 NP_357923.1 CDS pbpA NC_003098.1 332863 335022 R penicillin-binding protein 1A complement(332863..335022) Streptococcus pneumoniae R6 934791 NP_357924.1 CDS recU NC_003098.1 335019 335615 R functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease complement(335019..335615) Streptococcus pneumoniae R6 934793 NP_357925.1 CDS spr0331 NC_003098.1 335681 336208 D hypothetical protein 335681..336208 Streptococcus pneumoniae R6 934808 NP_357926.1 CDS spr0332 NC_003098.1 336266 336607 D hypothetical protein 336266..336607 Streptococcus pneumoniae R6 934797 NP_357927.1 CDS spr0333 NC_003098.1 337078 338250 D hypothetical protein 337078..338250 Streptococcus pneumoniae R6 934806 NP_357928.1 CDS spr0334 NC_003098.1 338263 339657 D hypothetical protein 338263..339657 Streptococcus pneumoniae R6 934807 NP_357929.1 CDS gnd NC_003098.1 339733 341157 D catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 339733..341157 Streptococcus pneumoniae R6 934817 NP_357930.1 CDS csrR NC_003098.1 341169 341858 D DNA-binding response regulator 341169..341858 Streptococcus pneumoniae R6 934805 NP_357931.1 CDS cbpF NC_003098.1 341956 342972 D choline-binding protein F 341956..342972 Streptococcus pneumoniae R6 934810 NP_357932.1 CDS mvk NC_003098.1 343094 343972 D mevalonate kinase 343094..343972 Streptococcus pneumoniae R6 934821 NP_357933.1 CDS mvd1 NC_003098.1 343873 344907 D diphosphomevalonate decarboxylase 343873..344907 Streptococcus pneumoniae R6 934816 NP_357934.1 CDS mvaK2 NC_003098.1 344894 345901 D phosphomevalonate kinase 344894..345901 Streptococcus pneumoniae R6 934823 NP_357935.1 CDS fni NC_003098.1 345885 346895 D catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 345885..346895 Streptococcus pneumoniae R6 934831 NP_357936.1 CDS spr0342 NC_003098.1 346973 347671 D hypothetical protein 346973..347671 Streptococcus pneumoniae R6 934819 NP_357937.1 CDS hk03 NC_003098.1 347668 348663 D sensor histidine kinase 347668..348663 Streptococcus pneumoniae R6 934820 NP_357938.1 CDS rr03 NC_003098.1 348677 349309 D DNA-binding response regulator 348677..349309 Streptococcus pneumoniae R6 934829 NP_357942.1 CDS spr0348 NC_003098.1 350229 350423 D hypothetical protein 350229..350423 Streptococcus pneumoniae R6 934818 NP_357945.1 CDS pcpC NC_003098.1 351393 352277 D choline-binding protein 351393..352277 Streptococcus pneumoniae R6 934801 NP_357950.1 CDS mtlA NC_003098.1 353760 355529 D PTS system mannitol-specific transporter subunit IIBC 353760..355529 Streptococcus pneumoniae R6 934701 NP_357951.1 CDS spr0357 NC_003098.1 355553 357508 D transcriptional regulator 355553..357508 Streptococcus pneumoniae R6 934715 NP_357952.1 CDS mtlF NC_003098.1 357510 357947 D PTS system mannitol-specific transporter subunit IIA 357510..357947 Streptococcus pneumoniae R6 932976 NP_357953.1 CDS mtlD NC_003098.1 358009 359145 D mannitol-1-phosphate 5-dehydrogenase 358009..359145 Streptococcus pneumoniae R6 933124 NP_357956.1 CDS tig NC_003098.1 359944 361227 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 359944..361227 Streptococcus pneumoniae R6 933930 NP_357957.1 CDS recD NC_003098.1 361275 363641 R exonuclease V complement(361275..363641) Streptococcus pneumoniae R6 934058 NP_357958.1 CDS spi NC_003098.1 363875 364489 R signal peptidase I complement(363875..364489) Streptococcus pneumoniae R6 934640 NP_357959.1 CDS rnhB NC_003098.1 364501 365373 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII complement(364501..365373) Streptococcus pneumoniae R6 933085 NP_357960.1 CDS spr0366 NC_003098.1 365451 365762 D hypothetical protein 365451..365762 Streptococcus pneumoniae R6 934835 NP_357961.1 CDS spr0367 NC_003098.1 365759 366307 D hypothetical protein 365759..366307 Streptococcus pneumoniae R6 934646 NP_357962.1 CDS mutS2 NC_003098.1 366411 368747 D MutS2 family protein 366411..368747 Streptococcus pneumoniae R6 934644 NP_357963.1 CDS dagA NC_003098.1 369089 370411 D sodium:alanine symporter family protein 369089..370411 Streptococcus pneumoniae R6 934641 NP_357964.1 CDS mip NC_003098.1 370629 371177 D hypothetical protein 370629..371177 Streptococcus pneumoniae R6 934649 NP_357965.1 CDS shetA NC_003098.1 371275 372186 D exfoliative toxin 371275..372186 Streptococcus pneumoniae R6 934642 NP_357966.2 CDS serS NC_003098.1 372211 373485 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(372211..373485) Streptococcus pneumoniae R6 934643 NP_357967.1 CDS spr0373 NC_003098.1 373698 374069 R hypothetical protein complement(373698..374069) Streptococcus pneumoniae R6 934651 NP_357968.1 CDS lysC NC_003098.1 374072 375436 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase complement(374072..375436) Streptococcus pneumoniae R6 934653 NP_357969.1 CDS phaB NC_003098.1 375761 376546 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 375761..376546 Streptococcus pneumoniae R6 934663 NP_357970.1 CDS spr0376 NC_003098.1 376640 377074 D Probable transcriptional regulator; hypothetical protein 376640..377074 Streptococcus pneumoniae R6 934658 NP_357971.1 CDS fabH NC_003098.1 377074 378048 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 377074..378048 Streptococcus pneumoniae R6 934655 NP_357972.1 CDS acpP NC_003098.1 378108 378332 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 378108..378332 Streptococcus pneumoniae R6 934673 NP_357973.1 CDS fabK NC_003098.1 378451 379425 D enoyl-acyl carrier protein(ACP) reductase 378451..379425 Streptococcus pneumoniae R6 934670 NP_357974.1 CDS fabD NC_003098.1 379418 380338 D ACP S-malonyltransferase 379418..380338 Streptococcus pneumoniae R6 934657 NP_357975.1 CDS fabG NC_003098.1 380372 381103 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 380372..381103 Streptococcus pneumoniae R6 934672 NP_357976.1 CDS fabF NC_003098.1 381116 382360 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 381116..382360 Streptococcus pneumoniae R6 934660 NP_357977.1 CDS accB NC_003098.1 382363 382848 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 382363..382848 Streptococcus pneumoniae R6 934665 NP_357978.1 CDS fabZ NC_003098.1 382845 383267 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 382845..383267 Streptococcus pneumoniae R6 934674 NP_357979.1 CDS accC NC_003098.1 383279 384646 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 383279..384646 Streptococcus pneumoniae R6 934681 NP_357980.1 CDS accD NC_003098.1 384683 385549 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 384683..385549 Streptococcus pneumoniae R6 934669 NP_357981.1 CDS accA NC_003098.1 385546 386313 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha 385546..386313 Streptococcus pneumoniae R6 934683 NP_357984.1 CDS nusB NC_003098.1 387424 387864 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(387424..387864) Streptococcus pneumoniae R6 934688 NP_357985.1 CDS spr0391 NC_003098.1 387839 388228 R hypothetical protein complement(387839..388228) Streptococcus pneumoniae R6 934678 NP_357986.1 CDS efp NC_003098.1 388250 388810 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(388250..388810) Streptococcus pneumoniae R6 934680 NP_357987.1 CDS gatB NC_003098.1 388939 390381 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(388939..390381) Streptococcus pneumoniae R6 934697 NP_357988.1 CDS gatA NC_003098.1 390381 391847 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(390381..391847) Streptococcus pneumoniae R6 934695 NP_357989.1 CDS gatC NC_003098.1 391847 392149 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(391847..392149) Streptococcus pneumoniae R6 934685 NP_357990.1 CDS prfC NC_003098.1 392362 393906 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 392362..393906 Streptococcus pneumoniae R6 934704 NP_357991.1 CDS spr0397 NC_003098.1 394175 394660 D hypothetical protein 394175..394660 Streptococcus pneumoniae R6 934691 NP_357992.1 CDS rpmB NC_003098.1 394776 394964 D required for 70S ribosome assembly; 50S ribosomal protein L28 394776..394964 Streptococcus pneumoniae R6 934689 NP_357993.1 CDS asp23 NC_003098.1 395121 395486 D hypothetical protein 395121..395486 Streptococcus pneumoniae R6 934702 NP_357994.1 CDS spr0400 NC_003098.1 395489 397156 D hypothetical protein 395489..397156 Streptococcus pneumoniae R6 934693 NP_357995.1 CDS ilvB NC_003098.1 397357 399057 D catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit 397357..399057 Streptococcus pneumoniae R6 934698 NP_357996.1 CDS ilvH NC_003098.1 399026 399526 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 399026..399526 Streptococcus pneumoniae R6 934725 NP_357997.1 CDS ilvC NC_003098.1 399592 400614 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 399592..400614 Streptococcus pneumoniae R6 934707 NP_357999.1 CDS spr0405 NC_003098.1 401195 401551 D hypothetical protein 401195..401551 Streptococcus pneumoniae R6 934721 NP_358000.1 CDS ilvA NC_003098.1 401601 402851 D catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 401601..402851 Streptococcus pneumoniae R6 934708 NP_358001.1 CDS spr0407 NC_003098.1 403586 403801 D hypothetical protein 403586..403801 Streptococcus pneumoniae R6 934719 NP_358002.1 CDS glnQ NC_003098.1 403910 404650 R amino acid ABC transporter ATP-binding protein complement(403910..404650) Streptococcus pneumoniae R6 934709 NP_358003.2 CDS glnH NC_003098.1 404650 406215 R glutamine ABC transporter substrate-binding protein complement(404650..406215) Streptococcus pneumoniae R6 934710 NP_358004.1 CDS spr0410 NC_003098.1 406350 408242 D hypothetical protein 406350..408242 Streptococcus pneumoniae R6 934724 NP_358007.1 CDS uppP NC_003098.1 409666 410511 D BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 409666..410511 Streptococcus pneumoniae R6 934740 NP_358008.1 CDS dinP NC_003098.1 410657 411727 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(410657..411727) Streptococcus pneumoniae R6 934718 NP_358009.1 CDS pfl NC_003098.1 412113 414437 D formate acetyltransferase 412113..414437 Streptococcus pneumoniae R6 934727 NP_358010.1 CDS spr0416 NC_003098.1 414804 415151 R hypothetical protein complement(414804..415151) Streptococcus pneumoniae R6 934736 NP_358011.1 CDS spr0417 NC_003098.1 415349 415633 R hypothetical protein complement(415349..415633) Streptococcus pneumoniae R6 934731 NP_358014.1 CDS xylR NC_003098.1 417068 418291 R ROK family protein complement(417068..418291) Streptococcus pneumoniae R6 934739 NP_358015.1 CDS PTS-EII NC_003098.1 418456 419781 D PTS system cellobiose-specific transporter subunit IIC 418456..419781 Streptococcus pneumoniae R6 934738 NP_358016.1 CDS spr0422 NC_003098.1 419729 421669 D hypothetical protein 419729..421669 Streptococcus pneumoniae R6 934749 NP_358017.1 CDS PTS-EII NC_003098.1 421837 422181 D PTS system lactose-specific transporter subunit IIA 421837..422181 Streptococcus pneumoniae R6 934748 NP_358018.1 CDS lacG NC_003098.1 422191 423603 D catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 422191..423603 Streptococcus pneumoniae R6 934741 NP_358019.1 CDS PTS-EII NC_003098.1 423672 425351 D PTS system sugar-specific transporter subunit EII 423672..425351 Streptococcus pneumoniae R6 934754 NP_358020.1 CDS trkH NC_003098.1 425479 426918 R Trk transporter membrane-spanning protein complement(425479..426918) Streptococcus pneumoniae R6 934745 NP_358021.1 CDS trkA NC_003098.1 426922 428271 R involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component complement(426922..428271) Streptococcus pneumoniae R6 934746 NP_358022.1 CDS spr0428 NC_003098.1 428433 429308 D hypothetical protein 428433..429308 Streptococcus pneumoniae R6 934755 NP_358023.1 CDS spr0429 NC_003098.1 429323 429871 D hypothetical protein 429323..429871 Streptococcus pneumoniae R6 934767 NP_358024.1 CDS ABC-NBD NC_003098.1 430192 431874 D ABC transporter ATP-binding protein 430192..431874 Streptococcus pneumoniae R6 934771 NP_358025.1 CDS ABC-MSD NC_003098.1 431859 432689 D hypothetical protein 431859..432689 Streptococcus pneumoniae R6 934760 NP_358026.1 CDS cspR NC_003098.1 432843 433385 D rRNA methylase 432843..433385 Streptococcus pneumoniae R6 934758 NP_358027.1 CDS spr0433 NC_003098.1 433829 434407 D hypothetical protein 433829..434407 Streptococcus pneumoniae R6 934779 NP_358028.1 CDS spr0434 NC_003098.1 434397 435047 D Probable phosphatidic acid phosphatase; PAP2 family protein 434397..435047 Streptococcus pneumoniae R6 934762 NP_358029.1 CDS spr0435 NC_003098.1 435075 435464 D hypothetical protein 435075..435464 Streptococcus pneumoniae R6 934768 NP_358030.1 CDS spr0436 NC_003098.1 435469 435918 D hypothetical protein 435469..435918 Streptococcus pneumoniae R6 934769 NP_358031.2 CDS rpoE NC_003098.1 436046 436633 D participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 436046..436633 Streptococcus pneumoniae R6 934765 NP_358032.1 CDS pyrG NC_003098.1 437023 438630 D CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 437023..438630 Streptococcus pneumoniae R6 934794 NP_358033.1 CDS spr0439 NC_003098.1 439189 440820 R Probable integral membrane protein; hypothetical protein complement(439189..440820) Streptococcus pneumoniae R6 934792 NP_358034.1 CDS spr0440 NC_003098.1 441113 446092 D Similar to endo-beta-N-acetylglucosaminidase; endo-beta-N-acetylglucosaminidase 441113..446092 Streptococcus pneumoniae R6 934776 NP_358035.1 CDS pgk NC_003098.1 446182 447378 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 446182..447378 Streptococcus pneumoniae R6 934773 NP_358036.1 CDS spr0442 NC_003098.1 447514 448041 D hypothetical protein 447514..448041 Streptococcus pneumoniae R6 934790 NP_358037.1 CDS glnR NC_003098.1 448118 448474 D transcriptional repressor of the glutamine synthetase gene 448118..448474 Streptococcus pneumoniae R6 934781 NP_358038.1 CDS glnA NC_003098.1 448511 449857 D glutamine synthetase, type I 448511..449857 Streptococcus pneumoniae R6 934783 NP_358039.1 CDS hsdS NC_003098.1 450637 451917 D type I restriction-modification system S subunit 450637..451917 Streptococcus pneumoniae R6 934784 NP_358040.1 CDS hsdS NC_003098.1 451871 452470 R type I restriction-modification system S subunit complement(451871..452470) Streptococcus pneumoniae R6 934789 NP_358041.1 CDS xerD NC_003098.1 452481 453278 R integrase/recombinase complement(452481..453278) Streptococcus pneumoniae R6 934813 NP_358042.1 CDS hsdS NC_003098.1 453335 454903 R type I restriction-modification system S subunit complement(453335..454903) Streptococcus pneumoniae R6 934798 NP_358043.1 CDS hsdM NC_003098.1 454903 456366 R type I restriction-modification system M subunit complement(454903..456366) Streptococcus pneumoniae R6 934799 NP_358044.1 CDS hsdR NC_003098.1 456379 458712 R type I restriction-modification system R subunit complement(456379..458712) Streptococcus pneumoniae R6 934824 NP_358045.1 CDS spr0451 NC_003098.1 459085 459285 D hypothetical protein 459085..459285 Streptococcus pneumoniae R6 934800 NP_358046.1 CDS spr0452 NC_003098.1 459320 459829 D hypothetical protein 459320..459829 Streptococcus pneumoniae R6 934803 NP_358047.1 CDS hrcA NC_003098.1 459960 461027 D Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 459960..461027 Streptococcus pneumoniae R6 934815 NP_358048.1 CDS grpE NC_003098.1 461030 461578 D with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 461030..461578 Streptococcus pneumoniae R6 934809 NP_358049.1 CDS dnaK NC_003098.1 462058 463881 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 462058..463881 Streptococcus pneumoniae R6 934811 NP_358050.1 CDS dnaJ NC_003098.1 464641 465759 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 464641..465759 Streptococcus pneumoniae R6 934826 NP_358051.1 CDS spr0457 NC_003098.1 466094 466381 R hypothetical protein complement(466094..466381) Streptococcus pneumoniae R6 934812 NP_358052.1 CDS spr0458 NC_003098.1 466391 466801 R HIT-like protein; hypothetical protein complement(466391..466801) Streptococcus pneumoniae R6 934830 NP_358053.1 CDS ABC-NBD NC_003098.1 466869 467600 D ABC transporter ATP-binding protein 466869..467600 Streptococcus pneumoniae R6 934822 NP_358054.1 CDS ABC-MSP NC_003098.1 467597 468646 D ABC transporter permease 467597..468646 Streptococcus pneumoniae R6 934832 NP_358055.1 CDS blpT NC_003098.1 468814 469143 R hypothetical protein complement(468814..469143) Streptococcus pneumoniae R6 934827 NP_358056.1 CDS blpS NC_003098.1 469419 469757 D regulatory protein BlpS 469419..469757 Streptococcus pneumoniae R6 934833 NP_358057.1 CDS rr13 NC_003098.1 469762 470499 D response regulator BlpR 469762..470499 Streptococcus pneumoniae R6 933176 NP_358058.1 CDS hk13 NC_003098.1 470513 471853 D histidine kinase 470513..471853 Streptococcus pneumoniae R6 933263 NP_358059.1 CDS ip NC_003098.1 471895 472050 R peptide pheromone BlpC complement(471895..472050) Streptococcus pneumoniae R6 933743 NP_358064.1 CDS spr0470 NC_003098.1 475926 476159 D hypothetical protein 475926..476159 Streptococcus pneumoniae R6 933339 NP_358065.1 CDS spr0471 NC_003098.1 476175 476354 D hypothetical protein 476175..476354 Streptococcus pneumoniae R6 932909 NP_358066.1 CDS blpY NC_003098.1 476191 476880 D immunity protein BlpY 476191..476880 Streptococcus pneumoniae R6 933857 NP_358067.1 CDS blpZ NC_003098.1 476922 477155 D hypothetical protein 476922..477155 Streptococcus pneumoniae R6 933043 NP_358068.1 CDS pncP NC_003098.1 477306 477917 D ABC transporter ATP-binding protein 477306..477917 Streptococcus pneumoniae R6 933556 NP_358069.1 CDS spr0475 NC_003098.1 478078 478872 D hypothetical protein 478078..478872 Streptococcus pneumoniae R6 933194 NP_358070.1 CDS trmB NC_003098.1 478869 479504 D tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 478869..479504 Streptococcus pneumoniae R6 933048 NP_358071.1 CDS spr0477 NC_003098.1 479630 480109 D in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 479630..480109 Streptococcus pneumoniae R6 933553 NP_358072.1 CDS nusA NC_003098.1 480153 481289 D modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 480153..481289 Streptococcus pneumoniae R6 933557 NP_358073.1 CDS spr0479 NC_003098.1 481311 481604 D hypothetical protein 481311..481604 Streptococcus pneumoniae R6 933559 NP_358074.1 CDS spr0480 NC_003098.1 481597 481896 D Probable ribosomal protein; hypothetical protein 481597..481896 Streptococcus pneumoniae R6 933550 NP_358075.1 CDS infB NC_003098.1 481913 484705 D Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 481913..484705 Streptococcus pneumoniae R6 933555 NP_358076.1 CDS rbfA NC_003098.1 484929 485306 D associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 484929..485306 Streptococcus pneumoniae R6 933554 NP_358077.1 CDS spr0483 NC_003098.1 485549 486364 D hypothetical protein 485549..486364 Streptococcus pneumoniae R6 933552 NP_358078.1 CDS spr0484 NC_003098.1 486366 486548 D hypothetical protein 486366..486548 Streptococcus pneumoniae R6 933551 NP_358079.1 CDS spr0485 NC_003098.1 486986 487231 D hypothetical protein 486986..487231 Streptococcus pneumoniae R6 933549 NP_358080.1 CDS spr0486 NC_003098.1 487231 488565 D hypothetical protein 487231..488565 Streptococcus pneumoniae R6 933548 NP_358081.1 CDS spr0487 NC_003098.1 488575 488829 D hypothetical protein 488575..488829 Streptococcus pneumoniae R6 933542 NP_358082.1 CDS spr0488 NC_003098.1 488925 489320 D hypothetical protein 488925..489320 Streptococcus pneumoniae R6 933547 NP_358083.1 CDS spr0489 NC_003098.1 489732 490181 D hypothetical protein 489732..490181 Streptococcus pneumoniae R6 933546 NP_358084.1 CDS spr0490 NC_003098.1 490168 490725 D Probable acetyl transferase; hypothetical protein 490168..490725 Streptococcus pneumoniae R6 933539 NP_358085.1 CDS spr0491 NC_003098.1 490727 491689 D hypothetical protein 490727..491689 Streptococcus pneumoniae R6 933545 NP_358086.1 CDS valS NC_003098.1 491701 494352 D valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 491701..494352 Streptococcus pneumoniae R6 933544 NP_358087.1 CDS spr0493 NC_003098.1 494407 495177 D hypothetical protein 494407..495177 Streptococcus pneumoniae R6 933536 NP_358088.1 CDS spr0494 NC_003098.1 495460 496263 D cell filamentation protein Fic-related protein 495460..496263 Streptococcus pneumoniae R6 933541 NP_358093.1 CDS spr0499 NC_003098.1 497816 498883 D hypothetical protein 497816..498883 Streptococcus pneumoniae R6 933531 NP_358098.1 CDS licT NC_003098.1 500872 501711 D BglG family transcriptional antiterminator 500872..501711 Streptococcus pneumoniae R6 933525 NP_358099.1 CDS PTS-EII NC_003098.1 501729 503567 D PTS system beta-glucosides-specific transporter subunit IIABC 501729..503567 Streptococcus pneumoniae R6 933530 NP_358100.1 CDS bglH NC_003098.1 503580 504995 D 6-phospho-beta-glucosidase 503580..504995 Streptococcus pneumoniae R6 933529 NP_358101.2 CDS pheS NC_003098.1 505587 506633 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 505587..506633 Streptococcus pneumoniae R6 933527 NP_358102.1 CDS spr0508 NC_003098.1 506633 507142 D Probable transcriptional regulator; hypothetical protein 506633..507142 Streptococcus pneumoniae R6 933526 NP_358103.1 CDS pheT NC_003098.1 507219 509621 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 507219..509621 Streptococcus pneumoniae R6 933519 NP_358104.1 CDS spr0510 NC_003098.1 509689 510690 R hypothetical protein complement(509689..510690) Streptococcus pneumoniae R6 933523 NP_358107.1 CDS spr0513 NC_003098.1 511419 511685 D hypothetical protein 511419..511685 Streptococcus pneumoniae R6 933521 NP_358108.1 CDS metE NC_003098.1 511802 514195 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 511802..514195 Streptococcus pneumoniae R6 933520 NP_358109.1 CDS metF NC_003098.1 514259 515125 D 5,10-methylenetetrahydrofolate reductase 514259..515125 Streptococcus pneumoniae R6 933513 NP_358110.1 CDS pnpA NC_003098.1 515696 518023 D polynucleotide phosphorylase 515696..518023 Streptococcus pneumoniae R6 933518 NP_358111.1 CDS cysE NC_003098.1 518039 518656 D serine acetyltransferase 518039..518656 Streptococcus pneumoniae R6 933517 NP_358112.1 CDS spr0518 NC_003098.1 518668 519552 D hypothetical protein 518668..519552 Streptococcus pneumoniae R6 933510 NP_358113.1 CDS cysS NC_003098.1 519634 520977 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 519634..520977 Streptococcus pneumoniae R6 933515 NP_358114.1 CDS spr0520 NC_003098.1 520970 521356 D hypothetical protein 520970..521356 Streptococcus pneumoniae R6 933514 NP_358115.1 CDS spr0521 NC_003098.1 521360 522244 D Leucine rich protein; hypothetical protein 521360..522244 Streptococcus pneumoniae R6 933507 NP_358118.1 CDS vex1 NC_003098.1 523650 524927 D peptide ABC transporter permease 523650..524927 Streptococcus pneumoniae R6 933509 NP_358119.1 CDS vex2 NC_003098.1 524940 525587 D ABC transporter ATP-binding protein 524940..525587 Streptococcus pneumoniae R6 933508 NP_358120.1 CDS vex3 NC_003098.1 525639 527018 D peptide ABC transporter permease 525639..527018 Streptococcus pneumoniae R6 933495 NP_358122.1 CDS vncR NC_003098.1 527330 527986 D response regulator VncR 527330..527986 Streptococcus pneumoniae R6 933502 NP_358123.1 CDS vncS NC_003098.1 527983 529311 D histidine kinase VncS 527983..529311 Streptococcus pneumoniae R6 933480 NP_358124.1 CDS fba NC_003098.1 529452 530333 D catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 529452..530333 Streptococcus pneumoniae R6 933499 NP_358125.1 CDS spr0531 NC_003098.1 530654 531856 R Probable oxidoreductase; oxidoreductase complement(530654..531856) Streptococcus pneumoniae R6 933496 NP_358126.1 CDS glnP NC_003098.1 532102 532761 R amino acid ABC transporter permease complement(532102..532761) Streptococcus pneumoniae R6 933482 NP_358127.1 CDS glnP NC_003098.1 532771 533448 R amino acid ABC transporter permease complement(532771..533448) Streptococcus pneumoniae R6 933485 NP_358128.1 CDS glnH NC_003098.1 533461 534255 R amino acid ABC transporter amino acid-binding protein complement(533461..534255) Streptococcus pneumoniae R6 933401 NP_358131.1 CDS recJ NC_003098.1 535289 537523 D single-stranded-DNA-specific exonuclease RecJ 535289..537523 Streptococcus pneumoniae R6 933422 NP_358132.1 CDS spr0538 NC_003098.1 537698 539359 D metallo-beta-lactamase superfamily protein 537698..539359 Streptococcus pneumoniae R6 933405 NP_358133.1 CDS estA NC_003098.1 539428 540207 D tributyrin esterase 539428..540207 Streptococcus pneumoniae R6 933384 NP_358134.1 CDS murM NC_003098.1 540319 541539 D serine/alanine adding enzyme 540319..541539 Streptococcus pneumoniae R6 933395 NP_358135.1 CDS murN NC_003098.1 541544 542776 D beta-lactam resistance factor 541544..542776 Streptococcus pneumoniae R6 933396 NP_358136.1 CDS spr0542 NC_003098.1 542892 543551 D hypothetical protein 542892..543551 Streptococcus pneumoniae R6 933380 NP_358137.1 CDS uvrC NC_003098.1 543591 545435 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 543591..545435 Streptococcus pneumoniae R6 933390 NP_358138.1 CDS spr0544 NC_003098.1 545425 546258 D hypothetical protein 545425..546258 Streptococcus pneumoniae R6 933388 NP_358139.1 CDS ABC-SBP NC_003098.1 546440 547255 R glutamine ABC transporter substrate-binding protein complement(546440..547255) Streptococcus pneumoniae R6 933383 NP_358140.1 CDS nrd NC_003098.1 547411 548016 D nitroreductase 547411..548016 Streptococcus pneumoniae R6 933381 NP_358141.1 CDS pepV NC_003098.1 548029 549429 D divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 548029..549429 Streptococcus pneumoniae R6 933367 NP_358142.1 CDS spr0548 NC_003098.1 549483 550061 D hypothetical protein 549483..550061 Streptococcus pneumoniae R6 933378 NP_358145.1 CDS brnQ NC_003098.1 550668 552008 D branched chain amino acid ABC transporter carrier protein 550668..552008 Streptococcus pneumoniae R6 933369 NP_358146.1 CDS spr0552 NC_003098.1 552212 553249 D hypothetical protein 552212..553249 Streptococcus pneumoniae R6 933366 NP_358147.1 CDS spr0553 NC_003098.1 553218 553721 D HIT family protein 553218..553721 Streptococcus pneumoniae R6 933365 NP_358148.1 CDS spr0554 NC_003098.1 553724 554440 D carboxypeptidase; hypothetical protein 553724..554440 Streptococcus pneumoniae R6 933353 NP_358149.1 CDS rplK NC_003098.1 554749 555174 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 554749..555174 Streptococcus pneumoniae R6 933360 NP_358150.1 CDS rplA NC_003098.1 555382 556071 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 555382..556071 Streptococcus pneumoniae R6 933347 NP_358151.1 CDS ABC-NBD NC_003098.1 558589 559581 D ABC transporter ATP-binding protein 558589..559581 Streptococcus pneumoniae R6 933350 NP_358152.1 CDS spr0558 NC_003098.1 559541 560401 D hypothetical protein 559541..560401 Streptococcus pneumoniae R6 933348 NP_358153.1 CDS spr0559 NC_003098.1 560403 561188 D hypothetical protein 560403..561188 Streptococcus pneumoniae R6 933329 NP_358154.1 CDS spr0560 NC_003098.1 561441 561686 D hypothetical protein 561441..561686 Streptococcus pneumoniae R6 933343 YP_008719800.1 CDS spr0560a NC_003098.1 561962 562186 R hypothetical protein complement(561962..562186) Streptococcus pneumoniae R6 17374505 NP_358155.1 CDS prtA NC_003098.1 562418 568852 D cell wall-associated serine proteinase PrtA 562418..568852 Streptococcus pneumoniae R6 933322 NP_358156.1 CDS PTS-EII NC_003098.1 569431 569952 D PTS system transporter subunit IIA 569431..569952 Streptococcus pneumoniae R6 933332 NP_358157.1 CDS spr0563 NC_003098.1 569990 570295 D hypothetical protein 569990..570295 Streptococcus pneumoniae R6 933317 NP_358158.1 CDS PTS-EII NC_003098.1 570343 571818 D PTS system transporter subunit IIC 570343..571818 Streptococcus pneumoniae R6 933325 NP_358159.1 CDS bgaA NC_003098.1 572123 578809 D beta-galactosidase 572123..578809 Streptococcus pneumoniae R6 933305 NP_358161.1 CDS spr0567 NC_003098.1 579666 579911 R hypothetical protein complement(579666..579911) Streptococcus pneumoniae R6 933300 NP_358162.1 CDS spr0568 NC_003098.1 580123 580482 R hypothetical protein complement(580123..580482) Streptococcus pneumoniae R6 933310 NP_358163.1 CDS spr0569 NC_003098.1 580406 581026 D hypothetical protein 580406..581026 Streptococcus pneumoniae R6 933312 NP_358164.1 CDS spr0570 NC_003098.1 581084 581530 D hypothetical protein 581084..581530 Streptococcus pneumoniae R6 933299 NP_358165.1 CDS spr0571 NC_003098.1 581508 582071 D hypothetical protein 581508..582071 Streptococcus pneumoniae R6 933303 NP_358166.1 CDS spr0572 NC_003098.1 582064 582318 D hypothetical protein 582064..582318 Streptococcus pneumoniae R6 933301 NP_358167.1 CDS nha2 NC_003098.1 582330 584384 D sodium/hydrogen exchanger family protein 582330..584384 Streptococcus pneumoniae R6 933286 NP_358168.1 CDS spr0574 NC_003098.1 584548 585423 D ribonuclease BN 584548..585423 Streptococcus pneumoniae R6 933297 NP_358169.1 CDS ccdA NC_003098.1 585634 586344 D cytochrome c-type biogenesis protein 585634..586344 Streptococcus pneumoniae R6 933280 NP_358170.1 CDS spr0576 NC_003098.1 586337 586930 D hypothetical protein 586337..586930 Streptococcus pneumoniae R6 933294 NP_358171.1 CDS msrA NC_003098.1 586941 588053 D this fusion consists of methionine sulfoxide A reductase at the N-terminus and B at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion; bifunctional methionine sulfoxide reductase A/B protein 586941..588053 Streptococcus pneumoniae R6 933291 NP_358172.1 CDS rr09 NC_003098.1 588303 589058 D DNA-binding response regulator 588303..589058 Streptococcus pneumoniae R6 933285 NP_358173.1 CDS hk09 NC_003098.1 589055 590746 D sensor histidine kinase 589055..590746 Streptococcus pneumoniae R6 933281 NP_358174.1 CDS spr0580 NC_003098.1 590841 591425 D hypothetical protein 590841..591425 Streptococcus pneumoniae R6 933233 NP_358175.1 CDS zmpB NC_003098.1 591447 597077 D Similar to IgA1 protease; zinc metalloprotease 591447..597077 Streptococcus pneumoniae R6 933274 NP_358176.1 CDS pabB NC_003098.1 597147 598868 D Para-aminobenzoate synthetase 597147..598868 Streptococcus pneumoniae R6 933270 NP_358177.1 CDS spr0583 NC_003098.1 599026 600015 D Similar to 1,4-beta-N-acetylmuramidase; pneumococcal surface protein 599026..600015 Streptococcus pneumoniae R6 933221 NP_358178.1 CDS glcK NC_003098.1 600133 601110 D glucokinase 600133..601110 Streptococcus pneumoniae R6 933239 NP_358179.1 CDS thyA NC_003098.1 601207 602046 D ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 601207..602046 Streptococcus pneumoniae R6 933235 NP_358180.1 CDS spr0586 NC_003098.1 602094 602264 R hypothetical protein complement(602094..602264) Streptococcus pneumoniae R6 933200 NP_358182.1 CDS miaA NC_003098.1 602334 603269 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 602334..603269 Streptococcus pneumoniae R6 933224 NP_358183.1 CDS spr0589 NC_003098.1 603262 604500 D Probable GTP-binding protein; GTP-binding protein HflX 603262..604500 Streptococcus pneumoniae R6 933192 NP_358184.1 CDS spr0590 NC_003098.1 604493 605116 D hypothetical protein 604493..605116 Streptococcus pneumoniae R6 933210 NP_358185.1 CDS spr0591 NC_003098.1 605131 606060 D member of metallo-beta-lactamase; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 605131..606060 Streptococcus pneumoniae R6 933204 NP_358186.1 CDS spr0592 NC_003098.1 606081 606836 D Probable oxidoreductase; hypothetical protein 606081..606836 Streptococcus pneumoniae R6 933170 NP_358187.1 CDS cpsY NC_003098.1 606890 607936 R transcriptional regulator complement(606890..607936) Streptococcus pneumoniae R6 933196 NP_358188.1 CDS spr0594 NC_003098.1 607862 608131 D hypothetical protein 607862..608131 Streptococcus pneumoniae R6 933197 NP_358189.1 CDS spr0595 NC_003098.1 608131 608511 D hypothetical protein 608131..608511 Streptococcus pneumoniae R6 933145 NP_358190.1 CDS spr0596 NC_003098.1 608630 608827 D hypothetical protein 608630..608827 Streptococcus pneumoniae R6 933177 NP_358191.1 CDS rsuA NC_003098.1 608867 609592 R ribosomal small subunit pseudouridine synthase A complement(608867..609592) Streptococcus pneumoniae R6 933171 NP_358192.1 CDS typA NC_003098.1 609733 611595 D elongation factor Tu family protein 609733..611595 Streptococcus pneumoniae R6 933159 NP_358193.1 CDS spr0599 NC_003098.1 611615 611869 D hypothetical protein 611615..611869 Streptococcus pneumoniae R6 933150 NP_358194.1 CDS spr0600 NC_003098.1 612185 612532 D bacteriocin; hypothetical protein 612185..612532 Streptococcus pneumoniae R6 933142 NP_358195.1 CDS spr0601 NC_003098.1 612603 614624 D hypothetical protein 612603..614624 Streptococcus pneumoniae R6 933021 NP_358196.1 CDS ABC-NBD NC_003098.1 614626 615267 D sodium ABC transporter ATP-binding protein 614626..615267 Streptococcus pneumoniae R6 933012 NP_358197.1 CDS murD NC_003098.1 615371 616723 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 615371..616723 Streptococcus pneumoniae R6 932998 NP_358198.1 CDS murG NC_003098.1 616727 617785 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 616727..617785 Streptococcus pneumoniae R6 933002 NP_358199.1 CDS divIB NC_003098.1 617795 618985 D cell division protein DivIB 617795..618985 Streptococcus pneumoniae R6 932989 NP_358201.1 CDS spr0607 NC_003098.1 619725 620573 D hypothetical protein 619725..620573 Streptococcus pneumoniae R6 932983 NP_358205.1 CDS spr0611 NC_003098.1 622965 623678 D membrane spanning protein; hypothetical protein 622965..623678 Streptococcus pneumoniae R6 932963 NP_358207.1 CDS pyrF NC_003098.1 624413 625114 D OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 624413..625114 Streptococcus pneumoniae R6 932958 NP_358208.1 CDS pyrE NC_003098.1 625148 625780 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 625148..625780 Streptococcus pneumoniae R6 932949 NP_358209.1 CDS spr0615 NC_003098.1 625960 626364 D hypothetical protein 625960..626364 Streptococcus pneumoniae R6 934889 NP_358210.1 CDS spr0616 NC_003098.1 626460 627224 D hypothetical protein 626460..627224 Streptococcus pneumoniae R6 932946 NP_358211.1 CDS spr0617 NC_003098.1 627173 627976 D hypothetical protein 627173..627976 Streptococcus pneumoniae R6 932944 NP_358212.1 CDS spr0618 NC_003098.1 627980 628684 D hypothetical protein 627980..628684 Streptococcus pneumoniae R6 932924 NP_358213.1 CDS ABC-NBD NC_003098.1 628681 629328 D ABC transporter ATP-binding protein 628681..629328 Streptococcus pneumoniae R6 934873 NP_358216.1 CDS glnQ NC_003098.1 630285 631043 R amino acid ABC transporter ATP-binding protein complement(630285..631043) Streptococcus pneumoniae R6 934886 NP_358217.1 CDS glnP NC_003098.1 631044 631721 R amino acid ABC transporter permease complement(631044..631721) Streptococcus pneumoniae R6 932849 NP_358218.1 CDS glnP NC_003098.1 631681 632361 R amino acid ABC transporter permease complement(631681..632361) Streptococcus pneumoniae R6 932908 NP_358220.1 CDS lysS NC_003098.1 632850 634340 D class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 632850..634340 Streptococcus pneumoniae R6 932817 NP_358221.1 CDS lctO NC_003098.1 634965 636101 D lactate oxidase 634965..636101 Streptococcus pneumoniae R6 932862 NP_358222.1 CDS spr0628 NC_003098.1 636656 637324 D Probable transcriptional regulator; hypothetical protein 636656..637324 Streptococcus pneumoniae R6 932837 NP_358223.1 CDS thiM NC_003098.1 637592 638395 D catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 637592..638395 Streptococcus pneumoniae R6 934546 NP_358224.1 CDS thiE NC_003098.1 638397 639026 D thiamine-phosphate pyrophosphorylase 638397..639026 Streptococcus pneumoniae R6 932808 NP_358225.1 CDS spr0631 NC_003098.1 639551 640144 D hypothetical protein 639551..640144 Streptococcus pneumoniae R6 934636 NP_358226.1 CDS ABC-NBD NC_003098.1 640145 641530 D ABC transporter ATP-binding protein 640145..641530 Streptococcus pneumoniae R6 934174 NP_358227.1 CDS spr0633 NC_003098.1 641532 642182 D hypothetical protein 641532..642182 Streptococcus pneumoniae R6 934339 NP_358228.1 CDS tenA NC_003098.1 642193 642885 D extracellular enzyme gene transcriptional regulator 642193..642885 Streptococcus pneumoniae R6 934245 NP_358229.1 CDS spr0635 NC_003098.1 642890 643414 D hypothetical protein 642890..643414 Streptococcus pneumoniae R6 934493 NP_358230.1 CDS thiM NC_003098.1 643414 644217 D hydroxyethylthiazole kinase 643414..644217 Streptococcus pneumoniae R6 934435 NP_358231.1 CDS thiE NC_003098.1 644210 644842 D Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 644210..644842 Streptococcus pneumoniae R6 934175 NP_358232.1 CDS thiD NC_003098.1 645051 645842 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(645051..645842) Streptococcus pneumoniae R6 934176 NP_358233.1 CDS copY NC_003098.1 646178 646603 D COPAB ATPase metal-fist type repressor 646178..646603 Streptococcus pneumoniae R6 934180 NP_358234.1 CDS spr0640 NC_003098.1 646614 646985 D hypothetical protein 646614..646985 Streptococcus pneumoniae R6 934190 NP_358235.1 CDS ctpA NC_003098.1 646986 649238 D copper transporter P-type ATPase 646986..649238 Streptococcus pneumoniae R6 934178 NP_358236.1 CDS spxB NC_003098.1 649445 651220 D pyruvate oxidase 649445..651220 Streptococcus pneumoniae R6 934181 NP_358237.1 CDS spr0643 NC_003098.1 651331 651678 D hypothetical protein 651331..651678 Streptococcus pneumoniae R6 934177 NP_358238.1 CDS transposase_C NC_003098.1 651795 652448 R transposase complement(651795..652448) Streptococcus pneumoniae R6 934179 NP_358239.1 CDS spr0645 NC_003098.1 652336 652683 R hypothetical protein complement(652336..652683) Streptococcus pneumoniae R6 934183 NP_358241.1 CDS pmi NC_003098.1 653533 654477 D mannose-6-phosphate isomerase 653533..654477 Streptococcus pneumoniae R6 934184 NP_358242.1 CDS NS_transporter NC_003098.1 654580 655971 R sodium-dependent transporter complement(654580..655971) Streptococcus pneumoniae R6 934182 NP_358243.1 CDS mta NC_003098.1 656131 656793 D regulator of the multidrug efflux pump pmrA 656131..656793 Streptococcus pneumoniae R6 934189 NP_358244.1 CDS spr0650 NC_003098.1 656822 657277 R Similar to mutator protein MutT; hypothetical protein complement(656822..657277) Streptococcus pneumoniae R6 934185 NP_358245.1 CDS spr0651 NC_003098.1 657297 658490 R hypothetical protein complement(657297..658490) Streptococcus pneumoniae R6 934187 NP_358246.1 CDS spr0652 NC_003098.1 658531 659376 R hypothetical protein complement(658531..659376) Streptococcus pneumoniae R6 934192 NP_358247.1 CDS spr0653 NC_003098.1 659501 660058 D Probable transcriptional regulator; hypothetical protein 659501..660058 Streptococcus pneumoniae R6 934188 NP_358248.1 CDS comEB NC_003098.1 660077 660544 D late competence operon required for DNA binding and uptake; cytidine and deoxycytidylate deaminase 660077..660544 Streptococcus pneumoniae R6 934191 NP_358249.1 CDS upp NC_003098.1 660612 661262 D Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 660612..661262 Streptococcus pneumoniae R6 934196 NP_358250.1 CDS clpP NC_003098.1 661436 662026 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 661436..662026 Streptococcus pneumoniae R6 934194 NP_358251.1 CDS spr0657 NC_003098.1 662105 662353 D hypothetical protein 662105..662353 Streptococcus pneumoniae R6 934193 NP_358252.1 CDS spr0658 NC_003098.1 662219 662449 R hypothetical protein complement(662219..662449) Streptococcus pneumoniae R6 934197 NP_358253.1 CDS livJ NC_003098.1 662455 663615 D branched chain amino acid ABC transporter substrate+B481-binding protein 662455..663615 Streptococcus pneumoniae R6 934202 NP_358254.1 CDS livH NC_003098.1 663874 664752 D branched chain amino acid ABC transporter permease 663874..664752 Streptococcus pneumoniae R6 934200 NP_358255.1 CDS livM NC_003098.1 664756 665712 D branched chain amino acid ABC transporter permease 664756..665712 Streptococcus pneumoniae R6 934195 NP_358256.1 CDS livG NC_003098.1 665712 666476 D branched chain amino acid ABC transporter ATP-binding protein 665712..666476 Streptococcus pneumoniae R6 934198 NP_358257.1 CDS livF NC_003098.1 666476 667186 D branched chain amino acid ABC transporter ATP-binding protein 666476..667186 Streptococcus pneumoniae R6 934205 NP_358258.1 CDS spr0664 NC_003098.1 667600 668256 D acetoin utilization protein AcuB 667600..668256 Streptococcus pneumoniae R6 934199 NP_358259.1 CDS prfB NC_003098.1 668470 669459 D recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 668470..669459 Streptococcus pneumoniae R6 934204 NP_358260.1 CDS ftsE NC_003098.1 669477 670169 D ABC transporter ATP-binding protein 669477..670169 Streptococcus pneumoniae R6 934207 NP_358261.1 CDS ftsX NC_003098.1 670099 671088 D cell division ABC transporter permease FtsX 670099..671088 Streptococcus pneumoniae R6 934201 NP_358262.1 CDS ptsG NC_003098.1 671374 673554 D PTS system transporter subunit IIABC 671374..673554 Streptococcus pneumoniae R6 934203 NP_358263.1 CDS spr0669 NC_003098.1 673606 674421 D hypothetical protein 673606..674421 Streptococcus pneumoniae R6 934209 NP_358264.1 CDS rheB NC_003098.1 674561 675904 D ATP-dependent RNA helicase 674561..675904 Streptococcus pneumoniae R6 934208 NP_358265.1 CDS metK NC_003098.1 676119 677309 D methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 676119..677309 Streptococcus pneumoniae R6 934206 NP_358266.1 CDS pyrDA NC_003098.1 677862 678797 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 677862..678797 Streptococcus pneumoniae R6 934210 NP_358267.1 CDS holA NC_003098.1 678831 679868 D required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 678831..679868 Streptococcus pneumoniae R6 934219 NP_358268.1 CDS sodA NC_003098.1 680041 680646 D superoxide dismutase 680041..680646 Streptococcus pneumoniae R6 934215 NP_358269.1 CDS spr0675 NC_003098.1 680803 681333 D hypothetical protein 680803..681333 Streptococcus pneumoniae R6 934214 NP_358270.1 CDS spr0676 NC_003098.1 681354 682439 D 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 681354..682439 Streptococcus pneumoniae R6 934211 NP_358271.1 CDS spr0677 NC_003098.1 682441 682908 D hypothetical protein 682441..682908 Streptococcus pneumoniae R6 934218 NP_358272.1 CDS ABC-NBD NC_003098.1 682910 684451 D ABC transporter ATP-binding protein 682910..684451 Streptococcus pneumoniae R6 934213 NP_358273.1 CDS ppiA NC_003098.1 684508 685311 R peptidyl-prolyl cis-trans isomerase complement(684508..685311) Streptococcus pneumoniae R6 934212 NP_358274.1 CDS spr0680 NC_003098.1 685395 685616 R hypothetical protein complement(685395..685616) Streptococcus pneumoniae R6 934228 NP_358275.1 CDS spr0681 NC_003098.1 685504 685734 R hypothetical protein complement(685504..685734) Streptococcus pneumoniae R6 934216 NP_358276.1 CDS rpsP NC_003098.1 686482 686754 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 686482..686754 Streptococcus pneumoniae R6 934220 NP_358277.1 CDS spr0683 NC_003098.1 686774 687013 D hypothetical protein 686774..687013 Streptococcus pneumoniae R6 934222 NP_358280.1 CDS rimM NC_003098.1 688409 688927 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 688409..688927 Streptococcus pneumoniae R6 934224 NP_358281.1 CDS trmD NC_003098.1 688917 689636 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 688917..689636 Streptococcus pneumoniae R6 934221 NP_358282.1 CDS spr0688 NC_003098.1 689648 689986 D hypothetical protein 689648..689986 Streptococcus pneumoniae R6 934227 NP_358283.1 CDS spr0689 NC_003098.1 690017 690337 R hypothetical protein complement(690017..690337) Streptococcus pneumoniae R6 934226 NP_358284.1 CDS spr0690 NC_003098.1 690411 690650 D hypothetical protein 690411..690650 Streptococcus pneumoniae R6 934225 NP_358285.1 CDS bioY NC_003098.1 690854 691390 R biotin synthase complement(690854..691390) Streptococcus pneumoniae R6 934230 NP_358286.1 CDS gor NC_003098.1 691587 692933 R catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase complement(691587..692933) Streptococcus pneumoniae R6 934234 NP_358287.1 CDS spr0693 NC_003098.1 693198 694397 D hypothetical protein 693198..694397 Streptococcus pneumoniae R6 934233 NP_358288.1 CDS ABC-NBD NC_003098.1 694381 695082 D ABC transporter ATP-binding protein 694381..695082 Streptococcus pneumoniae R6 934229 NP_358289.1 CDS spr0695 NC_003098.1 695084 696343 D hypothetical protein 695084..696343 Streptococcus pneumoniae R6 934232 NP_358290.2 CDS metG NC_003098.1 696467 698464 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 696467..698464 Streptococcus pneumoniae R6 934240 YP_008719801.1 CDS spr0696a NC_003098.1 698514 698705 D hypothetical protein 698514..698705 Streptococcus pneumoniae R6 17374506 NP_358291.1 CDS spr0697 NC_003098.1 698792 699115 D hypothetical protein 698792..699115 Streptococcus pneumoniae R6 934231 NP_358292.1 CDS spr0698 NC_003098.1 699119 699994 D hypothetical protein 699119..699994 Streptococcus pneumoniae R6 934238 NP_358293.1 CDS spr0699 NC_003098.1 700006 700935 D hypothetical protein 700006..700935 Streptococcus pneumoniae R6 934236 NP_358294.1 CDS spr0700 NC_003098.1 701014 701271 D hypothetical protein 701014..701271 Streptococcus pneumoniae R6 934235 NP_358295.1 CDS fabG NC_003098.1 701264 701962 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 701264..701962 Streptococcus pneumoniae R6 934242 NP_358296.1 CDS spr0702 NC_003098.1 701973 702452 D MutT/nudix family protein 701973..702452 Streptococcus pneumoniae R6 934237 NP_358297.1 CDS spr0703 NC_003098.1 702460 703188 D hypothetical protein 702460..703188 Streptococcus pneumoniae R6 934250 NP_358298.1 CDS spr0704 NC_003098.1 703224 704099 D hypothetical protein 703224..704099 Streptococcus pneumoniae R6 934243 NP_358299.1 CDS spr0705 NC_003098.1 704074 704514 D hypothetical protein 704074..704514 Streptococcus pneumoniae R6 934239 NP_358300.1 CDS pepN NC_003098.1 704637 707183 D aminopeptidase 704637..707183 Streptococcus pneumoniae R6 934241 NP_358301.1 CDS ciaR NC_003098.1 707226 707966 D DNA-binding response regulator CiaR 707226..707966 Streptococcus pneumoniae R6 934251 NP_358302.1 CDS ciaH NC_003098.1 707956 709290 D sensor histidine kinase CiaH 707956..709290 Streptococcus pneumoniae R6 934244 NP_358303.1 CDS spr0709 NC_003098.1 709324 709611 R hypothetical protein complement(709324..709611) Streptococcus pneumoniae R6 934248 NP_358304.1 CDS spr0710 NC_003098.1 709610 710680 D Similar to protease; hypothetical protein 709610..710680 Streptococcus pneumoniae R6 934270 NP_358305.1 CDS dinG NC_003098.1 710880 713330 D unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 710880..713330 Streptococcus pneumoniae R6 934246 NP_358306.1 CDS rodA NC_003098.1 713340 714590 D rod shape-determining protein RodA 713340..714590 Streptococcus pneumoniae R6 934247 NP_358307.1 CDS thiJ NC_003098.1 714601 715155 D 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein 714601..715155 Streptococcus pneumoniae R6 934252 NP_358308.1 CDS gph NC_003098.1 715231 715803 D phosphoglycolate phosphatase 715231..715803 Streptococcus pneumoniae R6 934249 NP_358309.1 CDS gyrB NC_003098.1 715818 717764 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 715818..717764 Streptococcus pneumoniae R6 934253 NP_358310.1 CDS ezrA NC_003098.1 717819 719573 D acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 717819..719573 Streptococcus pneumoniae R6 934258 NP_358311.1 CDS transposase_C NC_003098.1 720316 720720 D transposase 720316..720720 Streptococcus pneumoniae R6 934257 NP_358312.1 CDS transposase_D NC_003098.1 720608 721261 D transposase 720608..721261 Streptococcus pneumoniae R6 934256 NP_358314.1 CDS spr0720 NC_003098.1 721895 722194 R hypothetical protein complement(721895..722194) Streptococcus pneumoniae R6 934259 NP_358315.1 CDS spr0721 NC_003098.1 722359 722781 R MutT/nudix family protein complement(722359..722781) Streptococcus pneumoniae R6 934254 NP_358316.1 CDS transposase_A NC_003098.1 722874 723221 D transposase 722874..723221 Streptococcus pneumoniae R6 934263 NP_358319.1 CDS clpE NC_003098.1 723946 726204 R ATP dependent protease complement(723946..726204) Streptococcus pneumoniae R6 934262 NP_358320.1 CDS spr0726 NC_003098.1 726433 726663 R hypothetical protein complement(726433..726663) Streptococcus pneumoniae R6 934264 NP_358321.1 CDS glnP NC_003098.1 726847 727536 D amino acid ABC transporter permease 726847..727536 Streptococcus pneumoniae R6 934267 NP_358322.1 CDS glnQ NC_003098.1 727536 728270 D amino acid ABC transporter ATP-binding protein 727536..728270 Streptococcus pneumoniae R6 934265 NP_358323.1 CDS folD NC_003098.1 728361 729281 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 728361..729281 Streptococcus pneumoniae R6 934266 NP_358324.1 CDS spr0730 NC_003098.1 729423 730295 D hypothetical protein 729423..730295 Streptococcus pneumoniae R6 934273 NP_358325.1 CDS rpiA NC_003098.1 730520 731260 D Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 730520..731260 Streptococcus pneumoniae R6 934268 NP_358326.1 CDS deoB NC_003098.1 731211 732485 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 731211..732485 Streptococcus pneumoniae R6 934269 NP_358328.1 CDS pnp NC_003098.1 733045 733854 D catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 733045..733854 Streptococcus pneumoniae R6 934285 NP_358331.1 CDS spr0737 NC_003098.1 735335 735847 D Related to a cytolysin; hemolysin-like protein 735335..735847 Streptococcus pneumoniae R6 934271 NP_358332.1 CDS deoD NC_003098.1 736505 737215 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 736505..737215 Streptococcus pneumoniae R6 934280 NP_358333.1 CDS flaR NC_003098.1 737238 737762 R topology modulation protein complement(737238..737762) Streptococcus pneumoniae R6 934274 NP_358334.2 CDS rpsT NC_003098.1 737815 738051 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(737815..738051) Streptococcus pneumoniae R6 934276 NP_358335.1 CDS coaA NC_003098.1 738119 739069 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(738119..739069) Streptococcus pneumoniae R6 934284 NP_358336.1 CDS spr0742 NC_003098.1 739237 739677 D hypothetical protein 739237..739677 Streptococcus pneumoniae R6 934278 NP_358337.1 CDS spr0743 NC_003098.1 739884 740474 D hypothetical protein 739884..740474 Streptococcus pneumoniae R6 934279 NP_358338.1 CDS pdp NC_003098.1 740471 741748 D Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 740471..741748 Streptococcus pneumoniae R6 934286 NP_358339.1 CDS deoC NC_003098.1 741766 742428 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 741766..742428 Streptococcus pneumoniae R6 934282 NP_358340.1 CDS cdd NC_003098.1 742415 742804 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 742415..742804 Streptococcus pneumoniae R6 934281 NP_358341.1 CDS spr0747 NC_003098.1 742822 743946 D Similar to basic membrane protein A from Lactococcus lactis subsp. lactis; hypothetical protein 742822..743946 Streptococcus pneumoniae R6 934288 NP_358342.1 CDS ABC-NBD NC_003098.1 744090 745625 D sugar ABC transporter ATP-binding protein 744090..745625 Streptococcus pneumoniae R6 934283 NP_358343.1 CDS ABC-MSP NC_003098.1 745591 746676 D sugar ABC transporter permease 745591..746676 Streptococcus pneumoniae R6 934289 NP_358344.1 CDS ABC-MSP NC_003098.1 746679 747635 D sugar ABC transporter permease 746679..747635 Streptococcus pneumoniae R6 934291 NP_358349.1 CDS spr0755 NC_003098.1 749110 749751 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY complement(749110..749751) Streptococcus pneumoniae R6 934290 NP_358350.1 CDS parE NC_003098.1 749887 751830 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 749887..751830 Streptococcus pneumoniae R6 934298 NP_358351.1 CDS parC NC_003098.1 752241 754721 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 752241..754721 Streptococcus pneumoniae R6 934295 NP_358352.1 CDS ilvE NC_003098.1 754851 755873 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 754851..755873 Streptococcus pneumoniae R6 934293 NP_358354.1 CDS spr0760 NC_003098.1 756677 757387 D integral membrane protein; hypothetical protein 756677..757387 Streptococcus pneumoniae R6 934297 NP_358355.1 CDS spr0761 NC_003098.1 757384 758307 D membrane protein; hypothetical protein 757384..758307 Streptococcus pneumoniae R6 934296 NP_358356.1 CDS pcp NC_003098.1 758322 758966 D catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 758322..758966 Streptococcus pneumoniae R6 934303 NP_358357.1 CDS spr0763 NC_003098.1 759134 759364 D hypothetical protein 759134..759364 Streptococcus pneumoniae R6 934299 NP_358358.1 CDS rpsA NC_003098.1 759737 760939 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 759737..760939 Streptococcus pneumoniae R6 934311 NP_358361.1 CDS IS1167 NC_003098.1 761883 762401 R transposase complement(761883..762401) Streptococcus pneumoniae R6 934313 NP_358362.1 CDS spr0768 NC_003098.1 762595 763092 D hypothetical protein 762595..763092 Streptococcus pneumoniae R6 934307 NP_358363.1 CDS dnaX NC_003098.1 763092 764747 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 763092..764747 Streptococcus pneumoniae R6 934308 NP_358364.1 CDS spr0770 NC_003098.1 764775 764969 D hypothetical protein 764775..764969 Streptococcus pneumoniae R6 934314 NP_358365.1 CDS ABC-NBD NC_003098.1 765098 765889 D ABC transporter ATP-binding protein 765098..765889 Streptococcus pneumoniae R6 934309 NP_358366.1 CDS spr0772 NC_003098.1 765917 767179 D hypothetical protein 765917..767179 Streptococcus pneumoniae R6 934310 NP_358367.1 CDS spr0773 NC_003098.1 767190 768416 D Probable class-V aminotransferase; hypothetical protein 767190..768416 Streptococcus pneumoniae R6 934318 NP_358368.1 CDS nifU NC_003098.1 768403 768843 D NifU protein 768403..768843 Streptococcus pneumoniae R6 934312 NP_358369.1 CDS spr0775 NC_003098.1 768897 770309 D hypothetical protein 768897..770309 Streptococcus pneumoniae R6 934317 NP_358370.1 CDS dacA NC_003098.1 770508 771749 R D-alanyl-D-alanine carboxypeptidase complement(770508..771749) Streptococcus pneumoniae R6 934315 NP_358371.1 CDS spr0777 NC_003098.1 771852 772961 D permease; hypothetical protein 771852..772961 Streptococcus pneumoniae R6 934316 NP_358372.1 CDS fruR NC_003098.1 774386 775126 D lactose PTS system repressor 774386..775126 Streptococcus pneumoniae R6 934319 NP_358373.1 CDS fruB NC_003098.1 775123 776034 D 1-phosphofructokinase 775123..776034 Streptococcus pneumoniae R6 934324 NP_358374.1 CDS fruA NC_003098.1 776031 777983 D PTS system fructose specific transporter subunit IIABC 776031..777983 Streptococcus pneumoniae R6 934325 NP_358375.1 CDS ftsK NC_003098.1 778069 780372 D SpoE family protein 778069..780372 Streptococcus pneumoniae R6 934321 NP_358376.1 CDS spr0782 NC_003098.1 780417 780950 R hypothetical protein complement(780417..780950) Streptococcus pneumoniae R6 934327 NP_358377.1 CDS spr0783 NC_003098.1 780983 782125 D pyridoxal-phosphate dependent aminotransferase 780983..782125 Streptococcus pneumoniae R6 934333 NP_358378.1 CDS thiI NC_003098.1 782134 783348 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 782134..783348 Streptococcus pneumoniae R6 934323 NP_358379.1 CDS spr0785 NC_003098.1 783459 784307 D hypothetical protein 783459..784307 Streptococcus pneumoniae R6 934329 NP_358383.1 CDS spr0789 NC_003098.1 785081 786247 D hypothetical protein 785081..786247 Streptococcus pneumoniae R6 934330 NP_358384.1 CDS hsdM NC_003098.1 786755 788248 D type I restriction-modification system M subunit 786755..788248 Streptococcus pneumoniae R6 934337 NP_358385.1 CDS hsdS NC_003098.1 788261 788872 D type I restriction-modification system S subunit 788261..788872 Streptococcus pneumoniae R6 934328 NP_358386.1 CDS hsdR NC_003098.1 788951 792301 D type I restriction-modification system R subunit 788951..792301 Streptococcus pneumoniae R6 934335 YP_008719802.1 CDS spr0792a NC_003098.1 792572 792772 D hypothetical protein 792572..792772 Streptococcus pneumoniae R6 17374507 NP_358387.1 CDS argR NC_003098.1 792887 793357 R arginine repressor ArgR complement(792887..793357) Streptococcus pneumoniae R6 934338 NP_358388.1 CDS pepXP NC_003098.1 793374 795761 R catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase complement(793374..795761) Streptococcus pneumoniae R6 934358 NP_358389.1 CDS dnaE NC_003098.1 795966 799094 D Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 795966..799094 Streptococcus pneumoniae R6 934341 NP_358390.1 CDS pfkA NC_003098.1 799177 800184 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 799177..800184 Streptococcus pneumoniae R6 934334 NP_358391.1 CDS pykF NC_003098.1 800243 801748 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 800243..801748 Streptococcus pneumoniae R6 934336 NP_358393.1 CDS spr0799 NC_003098.1 803555 804427 D hypothetical protein 803555..804427 Streptococcus pneumoniae R6 934343 NP_358396.1 CDS spr0802 NC_003098.1 805060 805371 D hypothetical protein 805060..805371 Streptococcus pneumoniae R6 934344 NP_358397.1 CDS spr0803 NC_003098.1 805375 806091 D hypothetical protein 805375..806091 Streptococcus pneumoniae R6 934347 NP_358398.1 CDS spr0804 NC_003098.1 806221 807036 R hypothetical protein complement(806221..807036) Streptococcus pneumoniae R6 934349 NP_358399.1 CDS spr0805 NC_003098.1 807033 807938 R hypothetical protein complement(807033..807938) Streptococcus pneumoniae R6 934351 NP_358402.1 CDS tex NC_003098.1 809733 811880 D toxin expression transcriptional accessory protein 809733..811880 Streptococcus pneumoniae R6 934350 NP_358403.1 CDS spr0809 NC_003098.1 811867 812316 D hypothetical protein 811867..812316 Streptococcus pneumoniae R6 934348 NP_358404.1 CDS spr0810 NC_003098.1 812345 812647 D hypothetical protein 812345..812647 Streptococcus pneumoniae R6 934356 NP_358405.1 CDS spr0811 NC_003098.1 813001 813192 R hypothetical protein complement(813001..813192) Streptococcus pneumoniae R6 934355 NP_358406.1 CDS ABC-NBD NC_003098.1 813563 814378 D ABC transporter ATP-binding protein 813563..814378 Streptococcus pneumoniae R6 934359 NP_358407.1 CDS ABC-MSD NC_003098.1 814380 816368 D ABC transporter permease 814380..816368 Streptococcus pneumoniae R6 934353 NP_358408.1 CDS spr0814 NC_003098.1 816411 817001 R hypothetical protein complement(816411..817001) Streptococcus pneumoniae R6 934354 NP_358409.1 CDS spr0815 NC_003098.1 817081 818001 R transposase complement(817081..818001) Streptococcus pneumoniae R6 934360 NP_358410.1 CDS cad NC_003098.1 818663 820138 D lysine decarboxylase 818663..820138 Streptococcus pneumoniae R6 934357 NP_358413.1 CDS speE NC_003098.1 821075 821935 D catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 821075..821935 Streptococcus pneumoniae R6 934362 NP_358414.1 CDS spr0820 NC_003098.1 821932 823191 D hypothetical protein 821932..823191 Streptococcus pneumoniae R6 934369 NP_358415.1 CDS nspC NC_003098.1 823191 824318 D carboxynorspermidine decarboxylase 823191..824318 Streptococcus pneumoniae R6 934364 NP_358416.1 CDS spr0822 NC_003098.1 824315 825400 D catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis; agmatine deiminase 824315..825400 Streptococcus pneumoniae R6 934363 NP_358417.1 CDS but NC_003098.1 825410 826285 D beta-alanine synthase or beta-ureidopropionase 825410..826285 Streptococcus pneumoniae R6 934377 NP_358418.1 CDS spr0824 NC_003098.1 826466 827275 R Cof family protein complement(826466..827275) Streptococcus pneumoniae R6 934365 NP_358419.1 CDS spr0825 NC_003098.1 827547 827768 D hypothetical protein 827547..827768 Streptococcus pneumoniae R6 934366 NP_358420.1 CDS spr0826 NC_003098.1 827822 828493 D hypothetical protein 827822..828493 Streptococcus pneumoniae R6 934373 NP_358422.1 CDS cpsY NC_003098.1 828735 829643 D regulatory function on capsule expression in group B streptococci 828735..829643 Streptococcus pneumoniae R6 934370 NP_358423.1 CDS lspA NC_003098.1 829640 830101 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 829640..830101 Streptococcus pneumoniae R6 934374 NP_358424.1 CDS rluD NC_003098.1 830091 830978 D ribosomal large subunit pseudouridine synthase D 830091..830978 Streptococcus pneumoniae R6 934371 NP_358425.1 CDS lytD NC_003098.1 830981 832864 D choline binding protein E 830981..832864 Streptococcus pneumoniae R6 934372 NP_358426.1 CDS proB NC_003098.1 832944 834074 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 832944..834074 Streptococcus pneumoniae R6 934389 NP_358427.1 CDS proA NC_003098.1 834084 835346 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 834084..835346 Streptococcus pneumoniae R6 934375 NP_358428.1 CDS proC NC_003098.1 835350 836147 D pyrroline-5-carboxylate reductase 835350..836147 Streptococcus pneumoniae R6 934378 NP_358429.1 CDS tmk NC_003098.1 836263 836901 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 836263..836901 Streptococcus pneumoniae R6 934382 NP_358430.1 CDS holB NC_003098.1 836898 837788 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 836898..837788 Streptococcus pneumoniae R6 934380 NP_358431.1 CDS spr0837 NC_003098.1 837801 838145 D in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 837801..838145 Streptococcus pneumoniae R6 934376 NP_358432.1 CDS spr0838 NC_003098.1 838148 839017 D hypothetical protein 838148..839017 Streptococcus pneumoniae R6 934385 NP_358433.1 CDS spr0839 NC_003098.1 839217 839762 D hypothetical protein 839217..839762 Streptococcus pneumoniae R6 934379 NP_358434.1 CDS spr0840 NC_003098.1 839871 840518 D hypothetical protein 839871..840518 Streptococcus pneumoniae R6 934381 NP_358435.1 CDS IS1381 NC_003098.1 840507 840896 R tranposase complement(840507..840896) Streptococcus pneumoniae R6 934387 NP_358436.1 CDS IS1381 NC_003098.1 840922 841311 R tranposase complement(840922..841311) Streptococcus pneumoniae R6 934383 NP_358438.1 CDS gidA NC_003098.1 841805 843139 D TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 841805..843139 Streptococcus pneumoniae R6 934391 NP_358439.1 CDS pyrH NC_003098.1 843217 843960 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 843217..843960 Streptococcus pneumoniae R6 934386 NP_358440.1 CDS frr NC_003098.1 843969 844526 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 843969..844526 Streptococcus pneumoniae R6 934401 NP_358441.1 CDS spr0847 NC_003098.1 844547 845440 D hypothetical protein 844547..845440 Streptococcus pneumoniae R6 934394 NP_358442.1 CDS spr0848 NC_003098.1 845449 845664 D hypothetical protein 845449..845664 Streptococcus pneumoniae R6 934388 NP_358443.1 CDS phoL NC_003098.1 845750 846718 D PhoH family protein 845750..846718 Streptococcus pneumoniae R6 934390 NP_358444.1 CDS spr0850 NC_003098.1 846911 847411 D hypothetical protein 846911..847411 Streptococcus pneumoniae R6 934396 NP_358449.1 CDS spr0855 NC_003098.1 849329 849898 D Probable acetyl transferase; hypothetical protein 849329..849898 Streptococcus pneumoniae R6 934395 NP_358450.1 CDS celA NC_003098.1 849966 850616 D Competence induced; comE-like protein A also known as CilE; DNA uptake by homology; competence protein CelA 849966..850616 Streptococcus pneumoniae R6 934400 NP_358451.1 CDS celB NC_003098.1 850600 852840 D Competence induced; comE-like protein B; DNA uptake by homology; competence protein CelB 850600..852840 Streptococcus pneumoniae R6 934397 NP_358454.1 CDS spr0860 NC_003098.1 853830 855011 D hypothetical protein 853830..855011 Streptococcus pneumoniae R6 934399 NP_358455.1 CDS infC NC_003098.1 855261 855848 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 855261..855848 Streptococcus pneumoniae R6 934403 NP_358456.1 CDS rpmI NC_003098.1 855881 856081 D 50S ribosomal protein L35 855881..856081 Streptococcus pneumoniae R6 933877 NP_358457.1 CDS rplT NC_003098.1 856133 856492 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 856133..856492 Streptococcus pneumoniae R6 934411 NP_358458.1 CDS lguL NC_003098.1 856499 856930 D lactoylglutathione lyase 856499..856930 Streptococcus pneumoniae R6 934408 NP_358459.1 CDS pyrDII NC_003098.1 857180 857980 D responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+); dihydroorotate dehydrogenase electron transfer subunit 857180..857980 Streptococcus pneumoniae R6 933866 NP_358460.2 CDS pyrD NC_003098.1 857991 858929 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 857991..858929 Streptococcus pneumoniae R6 934407 NP_358461.1 CDS lytB NC_003098.1 858971 861136 D endo-beta-N-acetylglucosaminidase 858971..861136 Streptococcus pneumoniae R6 934406 NP_358462.1 CDS flpA NC_003098.1 861197 862879 R adherence and virulence protein A complement(861197..862879) Streptococcus pneumoniae R6 933098 NP_358463.1 CDS spr0869 NC_003098.1 862957 863454 D metalloprotease 862957..863454 Streptococcus pneumoniae R6 934173 NP_358464.1 CDS dgkA NC_003098.1 863435 863830 D diacylglycerol kinase 863435..863830 Streptococcus pneumoniae R6 933031 NP_358465.1 CDS era NC_003098.1 863847 864746 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 863847..864746 Streptococcus pneumoniae R6 933913 NP_358466.1 CDS mutM NC_003098.1 864795 865619 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 864795..865619 Streptococcus pneumoniae R6 933206 NP_358467.1 CDS coaE NC_003098.1 865592 866224 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 865592..866224 Streptococcus pneumoniae R6 932960 NP_358469.1 CDS pmrA NC_003098.1 866211 867410 D major facilitator superfamily multi-drug resistance efflux pump 866211..867410 Streptococcus pneumoniae R6 933710 NP_358470.1 CDS rpmG NC_003098.1 867410 867559 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 867410..867559 Streptococcus pneumoniae R6 933739 NP_358471.1 CDS secG NC_003098.1 867599 867832 D preprotein translocase subunit SecG 867599..867832 Streptococcus pneumoniae R6 933638 NP_358472.1 CDS rnr NC_003098.1 867934 870288 D exoribonuclease R 867934..870288 Streptococcus pneumoniae R6 932871 NP_358473.1 CDS smpB NC_003098.1 870251 870718 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 870251..870718 Streptococcus pneumoniae R6 933888 NP_358474.1 CDS tehB NC_003098.1 870728 871594 D with TehA confers resistance to tellurite; tellurite resistance protein TehB 870728..871594 Streptococcus pneumoniae R6 932916 NP_358475.1 CDS coiA NC_003098.1 871667 872620 D Competence induced protein A; competence protein CoiA 871667..872620 Streptococcus pneumoniae R6 933951 NP_358476.1 CDS pepB NC_003098.1 872639 874441 D oligoendopeptidase F 872639..874441 Streptococcus pneumoniae R6 933006 NP_358477.1 CDS spr0883 NC_003098.1 874443 875156 D Probable methyltransferase; O-methyltransferase 874443..875156 Streptococcus pneumoniae R6 933962 NP_358478.1 CDS prsA NC_003098.1 875223 876164 D cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase PrsA 875223..876164 Streptococcus pneumoniae R6 932962 NP_358481.1 CDS gpmB NC_003098.1 877383 878003 R phosphoglycerate mutase complement(877383..878003) Streptococcus pneumoniae R6 933141 NP_358482.1 CDS ebsC NC_003098.1 878003 878485 R regulatory protein complement(878003..878485) Streptococcus pneumoniae R6 932797 NP_358483.1 CDS spr0889 NC_003098.1 878485 879327 R hypothetical protein complement(878485..879327) Streptococcus pneumoniae R6 932840 NP_358484.1 CDS spr0890 NC_003098.1 879422 880222 R hypothetical protein complement(879422..880222) Streptococcus pneumoniae R6 933046 NP_358485.1 CDS glmU NC_003098.1 880306 881745 D forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 880306..881745 Streptococcus pneumoniae R6 933167 NP_358486.1 CDS spr0892 NC_003098.1 881755 882300 D hypothetical protein 881755..882300 Streptococcus pneumoniae R6 932911 NP_358487.1 CDS spr0893 NC_003098.1 882279 882626 D hypothetical protein 882279..882626 Streptococcus pneumoniae R6 933247 NP_358488.1 CDS pfs NC_003098.1 882643 883335 D enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 882643..883335 Streptococcus pneumoniae R6 933030 NP_358489.1 CDS spr0895 NC_003098.1 883412 883903 D hypothetical protein 883412..883903 Streptococcus pneumoniae R6 932987 NP_358490.1 CDS dnaQ NC_003098.1 883965 884591 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 883965..884591 Streptococcus pneumoniae R6 934055 NP_358491.1 CDS spr0897 NC_003098.1 884594 886363 D hypothetical protein 884594..886363 Streptococcus pneumoniae R6 933351 NP_358494.1 CDS spr0900 NC_003098.1 887384 887584 D hypothetical protein 887384..887584 Streptococcus pneumoniae R6 933391 NP_358496.1 CDS spr0902 NC_003098.1 887626 888030 D hypothetical protein 887626..888030 Streptococcus pneumoniae R6 933860 NP_358497.1 CDS ccdA NC_003098.1 888261 888968 D cytochrome c-type biogenesis protein 888261..888968 Streptococcus pneumoniae R6 934067 NP_358498.1 CDS spr0904 NC_003098.1 888961 889536 D Similar to thiol:disulfide interchange protein; hypothetical protein 888961..889536 Streptococcus pneumoniae R6 933921 NP_358499.1 CDS yfnA NC_003098.1 889898 891301 D cationic amino acid transporter 889898..891301 Streptococcus pneumoniae R6 933721 NP_358500.1 CDS lmb NC_003098.1 891426 892361 D adhesion lipoprotein 891426..892361 Streptococcus pneumoniae R6 932947 NP_358501.1 CDS phtD NC_003098.1 892369 894930 D pneumococcal histidine triad protein D 892369..894930 Streptococcus pneumoniae R6 933304 NP_358502.1 CDS phtE NC_003098.1 895140 898259 D pneumococcal histidine triad protein E 895140..898259 Streptococcus pneumoniae R6 933256 NP_358506.1 CDS spr0912 NC_003098.1 900059 900688 D hypothetical protein 900059..900688 Streptococcus pneumoniae R6 933755 NP_358507.1 CDS pepT NC_003098.1 900731 901951 R catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T complement(900731..901951) Streptococcus pneumoniae R6 933013 NP_358508.1 CDS hemH NC_003098.1 902106 903200 D ferrochelatase 902106..903200 Streptococcus pneumoniae R6 933500 NP_358509.1 CDS mscL NC_003098.1 903242 903619 R large conductance mechanosensitive channel protein MscL complement(903242..903619) Streptococcus pneumoniae R6 932884 NP_358510.1 CDS mesH NC_003098.1 903701 904132 R GtrA family protein complement(903701..904132) Streptococcus pneumoniae R6 934062 NP_358511.1 CDS ccl NC_003098.1 904183 904764 D hypothetical protein 904183..904764 Streptococcus pneumoniae R6 932932 NP_358512.1 CDS asd NC_003098.1 905279 906355 D catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 905279..906355 Streptococcus pneumoniae R6 933797 NP_358513.1 CDS dapA NC_003098.1 906411 907346 D catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 906411..907346 Streptococcus pneumoniae R6 932822 NP_358514.2 CDS trmE NC_003098.1 907393 908766 R in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE complement(907393..908766) Streptococcus pneumoniae R6 933044 NP_358515.1 CDS xylH NC_003098.1 908903 909085 R 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase complement(908903..909085) Streptococcus pneumoniae R6 933810 NP_358516.1 CDS tdk NC_003098.1 909208 909807 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 909208..909807 Streptococcus pneumoniae R6 933593 NP_358517.1 CDS bltD NC_003098.1 909797 910276 D spermine/spermidine acetyltransferase 909797..910276 Streptococcus pneumoniae R6 933780 NP_358518.1 CDS prfA NC_003098.1 910286 911365 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 910286..911365 Streptococcus pneumoniae R6 933019 NP_358519.1 CDS hemK NC_003098.1 911365 912204 D HemK protein 911365..912204 Streptococcus pneumoniae R6 933764 NP_358520.1 CDS spr0926 NC_003098.1 912179 912790 D hypothetical protein 912179..912790 Streptococcus pneumoniae R6 933346 NP_358521.1 CDS spr0927 NC_003098.1 912753 913223 D hypothetical protein 912753..913223 Streptococcus pneumoniae R6 933156 NP_358522.1 CDS glyA NC_003098.1 913285 914541 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 913285..914541 Streptococcus pneumoniae R6 933588 NP_358523.1 CDS spr0929 NC_003098.1 914516 915523 D hypothetical protein 914516..915523 Streptococcus pneumoniae R6 933203 NP_358524.1 CDS spr0930 NC_003098.1 915523 916137 D RAS-related protein; hypothetical protein 915523..916137 Streptococcus pneumoniae R6 933699 NP_358525.1 CDS spr0931 NC_003098.1 916211 917185 D hypothetical protein 916211..917185 Streptococcus pneumoniae R6 933174 NP_358526.1 CDS spr0932 NC_003098.1 917259 918890 D Similar to RNA methyltransferase; hypothetical protein 917259..918890 Streptococcus pneumoniae R6 933763 YP_008719803.1 CDS spr0932a NC_003098.1 919089 919382 D hypothetical protein 919089..919382 Streptococcus pneumoniae R6 17374508 NP_358527.1 CDS spr0933 NC_003098.1 919628 919846 D hypothetical protein 919628..919846 Streptococcus pneumoniae R6 933497 NP_358528.1 CDS ABC-SBP NC_003098.1 920239 921264 D iron-compound ABC transporter substrate-binding protein 920239..921264 Streptococcus pneumoniae R6 933737 NP_358529.1 CDS ABC-MSP NC_003098.1 921242 922261 D iron-compound ABC transporter permease 921242..922261 Streptococcus pneumoniae R6 932842 NP_358530.1 CDS ABC-MSP NC_003098.1 922261 923268 D iron-compound ABC transporter permease 922261..923268 Streptococcus pneumoniae R6 933342 NP_358532.1 CDS ABC-NBD NC_003098.1 923268 924062 D iron-compound ABC transporter ATP-binding protein 923268..924062 Streptococcus pneumoniae R6 933605 NP_358533.1 CDS spr0939 NC_003098.1 924630 924839 D hypothetical protein 924630..924839 Streptococcus pneumoniae R6 933248 NP_358534.1 CDS spr0940 NC_003098.1 924964 925119 D hypothetical protein 924964..925119 Streptococcus pneumoniae R6 933805 NP_358535.1 CDS spr0941 NC_003098.1 925803 925964 D hypothetical protein 925803..925964 Streptococcus pneumoniae R6 933415 NP_358536.1 CDS ccrB NC_003098.1 926056 927735 D hypothetical protein 926056..927735 Streptococcus pneumoniae R6 933208 NP_358537.1 CDS spr0943 NC_003098.1 927958 928569 D hypothetical protein 927958..928569 Streptococcus pneumoniae R6 934059 NP_358539.1 CDS spr0945 NC_003098.1 929141 929956 D hypothetical protein 929141..929956 Streptococcus pneumoniae R6 933843 NP_358540.1 CDS spr0946 NC_003098.1 929956 930810 D hydrolase 929956..930810 Streptococcus pneumoniae R6 933884 NP_358541.1 CDS spr0947 NC_003098.1 930871 931806 D hypothetical protein 930871..931806 Streptococcus pneumoniae R6 933202 NP_358542.1 CDS nplT NC_003098.1 931945 933708 D neopullulanase 931945..933708 Streptococcus pneumoniae R6 933869 NP_358545.1 CDS spr0951 NC_003098.1 934826 935359 D transcriptional regulator 934826..935359 Streptococcus pneumoniae R6 932930 NP_358546.1 CDS spr0952 NC_003098.1 935359 936120 D hypothetical protein 935359..936120 Streptococcus pneumoniae R6 932821 NP_358549.1 CDS spr0955 NC_003098.1 938136 938495 D Hypothetical protein in TN5252; Tn5252, ORF 10 protein 938136..938495 Streptococcus pneumoniae R6 932940 NP_358550.1 CDS spr0956 NC_003098.1 938505 938834 D Tn5252, ORF 9 protein 938505..938834 Streptococcus pneumoniae R6 933068 NP_358553.1 CDS spr0959 NC_003098.1 940146 940742 D hypothetical protein 940146..940742 Streptococcus pneumoniae R6 933242 NP_358554.1 CDS mutR NC_003098.1 940787 941641 R positive transcriptional regulator MutR complement(940787..941641) Streptococcus pneumoniae R6 933784 NP_358555.1 CDS rffD NC_003098.1 941893 943188 D UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase 941893..943188 Streptococcus pneumoniae R6 933215 NP_358556.1 CDS spr0962 NC_003098.1 943148 943798 D hypothetical protein 943148..943798 Streptococcus pneumoniae R6 933584 NP_358557.1 CDS spr0963 NC_003098.1 943808 944590 D hypothetical protein 943808..944590 Streptococcus pneumoniae R6 933374 NP_358558.1 CDS spr0964 NC_003098.1 944613 946505 D hypothetical protein 944613..946505 Streptococcus pneumoniae R6 933298 NP_358559.1 CDS spr0965 NC_003098.1 946534 947640 D hypothetical protein 946534..947640 Streptococcus pneumoniae R6 934070 NP_358560.1 CDS spr0966 NC_003098.1 947648 948958 D Probable acid-CoA ligase; hypothetical protein 947648..948958 Streptococcus pneumoniae R6 933093 NP_358561.1 CDS spr0967 NC_003098.1 948960 950183 D hypothetical protein 948960..950183 Streptococcus pneumoniae R6 933966 NP_358562.1 CDS spr0968 NC_003098.1 950173 951123 D hypothetical protein 950173..951123 Streptococcus pneumoniae R6 933230 NP_358563.1 CDS nikS NC_003098.1 951138 952337 D nikkomycin biosynthesis protein, carboxylase 951138..952337 Streptococcus pneumoniae R6 933819 NP_358564.1 CDS spr0970 NC_003098.1 952356 953000 D Probable acetyltransferase; hypothetical protein 952356..953000 Streptococcus pneumoniae R6 933493 NP_358565.1 CDS mefE NC_003098.1 953383 954594 D macolide ABC transporter permease 953383..954594 Streptococcus pneumoniae R6 933922 NP_358566.1 CDS spr0972 NC_003098.1 955253 955474 D repressor protein; hypothetical protein 955253..955474 Streptococcus pneumoniae R6 933427 NP_358567.1 CDS ftsW NC_003098.1 956376 957605 D cell division protein FtsW 956376..957605 Streptococcus pneumoniae R6 933970 NP_358568.1 CDS ppc NC_003098.1 957625 960321 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 957625..960321 Streptococcus pneumoniae R6 932953 NP_358569.1 CDS ABC-SBP NC_003098.1 960704 961738 D hypothetical protein 960704..961738 Streptococcus pneumoniae R6 933181 NP_358570.1 CDS ABC-MSP NC_003098.1 961807 962673 D ABC transporter permease 961807..962673 Streptococcus pneumoniae R6 933290 NP_358571.1 CDS ABC-NBD NC_003098.1 962670 963428 D ABC transporter ATP-binding protein 962670..963428 Streptococcus pneumoniae R6 933967 NP_358572.1 CDS dnaG NC_003098.1 963503 965278 D synthesizes RNA primers at the replication forks; DNA primase 963503..965278 Streptococcus pneumoniae R6 933419 NP_358573.1 CDS rpoD NC_003098.1 965281 966390 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 965281..966390 Streptococcus pneumoniae R6 933267 NP_358574.1 CDS spr0980 NC_003098.1 966371 966733 D hypothetical protein 966371..966733 Streptococcus pneumoniae R6 933232 NP_358575.1 CDS cpoA NC_003098.1 966767 967891 D glycosyl transferase CpoA 966767..967891 Streptococcus pneumoniae R6 933377 NP_358576.1 CDS spr0982 NC_003098.1 967907 969232 D Probable hexosyltransferase; glycosyl transferase 967907..969232 Streptococcus pneumoniae R6 932928 NP_358577.1 CDS spr0983 NC_003098.1 969263 969439 D hypothetical protein 969263..969439 Streptococcus pneumoniae R6 933885 NP_358578.2 CDS obgE NC_003098.1 969702 971006 D essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 969702..971006 Streptococcus pneumoniae R6 933276 NP_358579.1 CDS spr0985 NC_003098.1 971016 971174 D hypothetical protein 971016..971174 Streptococcus pneumoniae R6 933219 NP_358582.1 CDS IS1167 NC_003098.1 972009 972563 R transposase complement(972009..972563) Streptococcus pneumoniae R6 932860 NP_358583.1 CDS murZ NC_003098.1 973796 975055 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 973796..975055 Streptococcus pneumoniae R6 933272 NP_358584.1 CDS spr0990 NC_003098.1 975065 975622 D Similar to alanine acetyl transferase; hypothetical protein 975065..975622 Streptococcus pneumoniae R6 932825 NP_358585.1 CDS spr0991 NC_003098.1 975615 976892 D hypothetical protein 975615..976892 Streptococcus pneumoniae R6 933905 NP_358586.1 CDS map NC_003098.1 976908 977768 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 976908..977768 Streptococcus pneumoniae R6 932841 NP_358587.1 CDS spr0993 NC_003098.1 977840 978547 D hypothetical protein 977840..978547 Streptococcus pneumoniae R6 933862 NP_358588.1 CDS IS1381 NC_003098.1 978562 978951 D tranposase 978562..978951 Streptococcus pneumoniae R6 933283 NP_358589.1 CDS pcrA NC_003098.1 979142 981433 D ATP-dependent DNA helicase PcrA 979142..981433 Streptococcus pneumoniae R6 932805 NP_358590.1 CDS radC NC_003098.1 981461 982156 D Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 981461..982156 Streptococcus pneumoniae R6 934080 NP_358591.1 CDS spr0997 NC_003098.1 982153 982842 R Probable amidotransferase; hypothetical protein complement(982153..982842) Streptococcus pneumoniae R6 934076 NP_358592.1 CDS spr0998 NC_003098.1 982860 983501 R modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex complement(982860..983501) Streptococcus pneumoniae R6 934078 NP_358593.1 CDS spr0999 NC_003098.1 983584 983835 R hypothetical protein complement(983584..983835) Streptococcus pneumoniae R6 934167 NP_358594.1 CDS spr1000 NC_003098.1 983807 984154 R hypothetical protein complement(983807..984154) Streptococcus pneumoniae R6 934034 NP_358595.1 CDS nifS NC_003098.1 984159 985274 R pyridoxal-phosphate dependent aminotransferase complement(984159..985274) Streptococcus pneumoniae R6 934171 NP_358596.1 CDS prs NC_003098.1 985284 986243 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(985284..986243) Streptococcus pneumoniae R6 932850 NP_358597.1 CDS spr1003 NC_003098.1 986356 986925 R hypothetical protein complement(986356..986925) Streptococcus pneumoniae R6 934074 NP_358598.1 CDS spr1004 NC_003098.1 987053 987724 D GTP pyrophosphokinase 987053..987724 Streptococcus pneumoniae R6 934631 NP_358599.1 CDS ppnK NC_003098.1 987696 988526 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 987696..988526 Streptococcus pneumoniae R6 934633 NP_358600.1 CDS rluD NC_003098.1 988523 989419 D 23S rRNA pseudouridine synthase 988523..989419 Streptococcus pneumoniae R6 933234 NP_358601.1 CDS eutD NC_003098.1 989463 990437 D in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 989463..990437 Streptococcus pneumoniae R6 933854 NP_358603.1 CDS IS1167 NC_003098.1 991498 992016 R transposase complement(991498..992016) Streptococcus pneumoniae R6 933833 NP_358604.1 CDS spr1010 NC_003098.1 992198 992497 R hypothetical protein complement(992198..992497) Streptococcus pneumoniae R6 933771 NP_358605.1 CDS spr1011 NC_003098.1 992899 993603 D hypothetical protein 992899..993603 Streptococcus pneumoniae R6 933761 NP_358606.1 CDS rplU NC_003098.1 993785 994099 D 50S ribosomal protein L21 993785..994099 Streptococcus pneumoniae R6 933955 NP_358607.1 CDS spr1013 NC_003098.1 994115 994459 D hypothetical protein 994115..994459 Streptococcus pneumoniae R6 933790 NP_358608.1 CDS rpmA NC_003098.1 994500 994769 D involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 994500..994769 Streptococcus pneumoniae R6 934115 NP_358611.1 CDS mreA NC_003098.1 995722 996639 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 995722..996639 Streptococcus pneumoniae R6 934162 NP_358612.1 CDS spr1018 NC_003098.1 996732 997580 R hypothetical protein complement(996732..997580) Streptococcus pneumoniae R6 934083 NP_358613.1 CDS spr1019 NC_003098.1 997722 998561 D Similar to Bacillus subtilis DegV protein; hypothetical protein 997722..998561 Streptococcus pneumoniae R6 934107 NP_358614.1 CDS hlpA NC_003098.1 998667 998942 D DNA-binding protein HU 998667..998942 Streptococcus pneumoniae R6 934105 NP_358615.1 CDS ABC-NBD NC_003098.1 999368 1001269 D ABC transporter ATP-binding protein 999368..1001269 Streptococcus pneumoniae R6 934100 NP_358616.1 CDS rggD NC_003098.1 1001242 1002135 D transcriptional regulator MutR 1001242..1002135 Streptococcus pneumoniae R6 934159 NP_358617.1 CDS ABC-MSP NC_003098.1 1002215 1003393 D macrolide ABC transporter permease 1002215..1003393 Streptococcus pneumoniae R6 932990 NP_358618.1 CDS ligA NC_003098.1 1003486 1005444 D this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1003486..1005444 Streptococcus pneumoniae R6 933694 NP_358619.1 CDS pulI NC_003098.1 1005556 1007835 D thermostable pullulanase 1005556..1007835 Streptococcus pneumoniae R6 932903 NP_358622.1 CDS gapN NC_003098.1 1008379 1009803 D glyceraldehyde-3-phosphate dehydrogenase 1008379..1009803 Streptococcus pneumoniae R6 933338 NP_358623.1 CDS glgB NC_003098.1 1010268 1012196 D catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 1010268..1012196 Streptococcus pneumoniae R6 933336 NP_358624.1 CDS glgC NC_003098.1 1012186 1013328 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1012186..1013328 Streptococcus pneumoniae R6 934106 NP_358625.1 CDS glgD NC_003098.1 1013318 1014457 D required for glycogen biosynthesis 1013318..1014457 Streptococcus pneumoniae R6 934104 NP_358626.1 CDS glgA NC_003098.1 1014454 1015887 D catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 1014454..1015887 Streptococcus pneumoniae R6 934118 NP_358628.1 CDS glxK NC_003098.1 1016588 1017715 D glycerate kinase 1016588..1017715 Streptococcus pneumoniae R6 934122 NP_358629.1 CDS spr1035 NC_003098.1 1017712 1018158 R hypothetical protein complement(1017712..1018158) Streptococcus pneumoniae R6 934154 NP_358630.1 CDS eno NC_003098.1 1018322 1019626 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1018322..1019626 Streptococcus pneumoniae R6 934109 NP_358632.1 CDS transposase_A NC_003098.1 1020607 1020975 R transposase complement(1020607..1020975) Streptococcus pneumoniae R6 934125 NP_358633.1 CDS rexB NC_003098.1 1021482 1024757 D second subunit of major exonuclease 1021482..1024757 Streptococcus pneumoniae R6 933876 NP_358634.1 CDS rexA NC_003098.1 1024754 1028404 D exonuclease RexA 1024754..1028404 Streptococcus pneumoniae R6 933887 NP_358635.1 CDS spr1041 NC_003098.1 1028574 1029752 D hypothetical protein 1028574..1029752 Streptococcus pneumoniae R6 933976 NP_358636.1 CDS iga NC_003098.1 1029961 1035852 D immunoglobulin A1 protease 1029961..1035852 Streptococcus pneumoniae R6 933909 NP_358637.1 CDS rbgA NC_003098.1 1036311 1037162 D essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1036311..1037162 Streptococcus pneumoniae R6 933067 NP_358638.1 CDS rnhB NC_003098.1 1037149 1037928 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1037149..1037928 Streptococcus pneumoniae R6 933032 NP_358639.1 CDS spr1045 NC_003098.1 1037929 1039494 D channel transporter; voltage-gated chloride channel family protein 1037929..1039494 Streptococcus pneumoniae R6 934627 NP_358640.1 CDS xerS NC_003098.1 1040078 1041148 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1040078..1041148 Streptococcus pneumoniae R6 934075 NP_358641.1 CDS lplA NC_003098.1 1041221 1042210 R lipoate-protein ligase complement(1041221..1042210) Streptococcus pneumoniae R6 934072 NP_358642.1 CDS acoL NC_003098.1 1042274 1043977 R dihydrolipoamide dehydrogenase complement(1042274..1043977) Streptococcus pneumoniae R6 934625 NP_358643.2 CDS acoC NC_003098.1 1044023 1045066 R unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain; dihydrolipoamide acetyltransferase complement(1044023..1045066) Streptococcus pneumoniae R6 934073 NP_358644.1 CDS acoB NC_003098.1 1045284 1046276 R acetoin dehydrogenase, E1 component subunit beta complement(1045284..1046276) Streptococcus pneumoniae R6 934165 NP_358645.1 CDS acoA NC_003098.1 1046292 1047260 R TPP-dependent acetoin dehydrogenase subunit alpha complement(1046292..1047260) Streptococcus pneumoniae R6 934170 NP_358646.1 CDS spr1052 NC_003098.1 1047414 1048775 R MATE efflux family protein complement(1047414..1048775) Streptococcus pneumoniae R6 934077 NP_358647.1 CDS pyrC NC_003098.1 1049060 1050328 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1049060..1050328) Streptococcus pneumoniae R6 934081 NP_358648.1 CDS mutX NC_003098.1 1050341 1050805 R 8-oxodGTP nucleoside triphosphatase complement(1050341..1050805) Streptococcus pneumoniae R6 933037 NP_358649.1 CDS ung NC_003098.1 1050815 1051483 R Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase complement(1050815..1051483) Streptococcus pneumoniae R6 933680 NP_358650.1 CDS spr1056 NC_003098.1 1051604 1052251 R hypothetical protein complement(1051604..1052251) Streptococcus pneumoniae R6 933471 NP_358651.1 CDS spr1057 NC_003098.1 1052265 1052978 R hypothetical protein complement(1052265..1052978) Streptococcus pneumoniae R6 932848 NP_358654.1 CDS phpA NC_003098.1 1054238 1056805 R histidine motif-containing protein complement(1054238..1056805) Streptococcus pneumoniae R6 933226 NP_358655.1 CDS phtA NC_003098.1 1056930 1059416 R pneumococcal histidine triad protein A complement(1056930..1059416) Streptococcus pneumoniae R6 933846 NP_358656.1 CDS ptsI NC_003098.1 1059635 1061368 R phosphoenolpyruvate-protein phosphotransferase complement(1059635..1061368) Streptococcus pneumoniae R6 933754 NP_358657.1 CDS ptsH NC_003098.1 1061374 1061637 R phosphocarrier protein HPr complement(1061374..1061637) Streptococcus pneumoniae R6 932807 NP_358658.1 CDS nrdH NC_003098.1 1061970 1062206 D glutaredoxin-like protein 1061970..1062206 Streptococcus pneumoniae R6 933182 NP_358659.1 CDS nrdE NC_003098.1 1062287 1064446 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1062287..1064446 Streptococcus pneumoniae R6 933455 NP_358660.1 CDS nrdF NC_003098.1 1064634 1065596 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1064634..1065596 Streptococcus pneumoniae R6 932802 NP_358661.1 CDS lacR NC_003098.1 1065778 1066539 D lactose PTS system repressor 1065778..1066539 Streptococcus pneumoniae R6 932931 NP_358662.1 CDS lacG NC_003098.1 1067037 1068443 R catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase complement(1067037..1068443) Streptococcus pneumoniae R6 932827 NP_358663.1 CDS lacE NC_003098.1 1068652 1070343 R PTS system lactose-specific transporter subunit IIBC complement(1068652..1070343) Streptococcus pneumoniae R6 933773 NP_358664.1 CDS lacF NC_003098.1 1070343 1070660 R PTS system lactose-specific transporter subunit IIA complement(1070343..1070660) Streptococcus pneumoniae R6 933794 NP_358665.1 CDS lacT NC_003098.1 1070696 1071532 R transcription antiterminator LacT complement(1070696..1071532) Streptococcus pneumoniae R6 932881 NP_358666.1 CDS lacD NC_003098.1 1071766 1072746 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase complement(1071766..1072746) Streptococcus pneumoniae R6 933800 NP_358667.1 CDS lacC NC_003098.1 1072748 1073677 R catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase complement(1072748..1073677) Streptococcus pneumoniae R6 933209 NP_358668.1 CDS lacB NC_003098.1 1073688 1074203 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB complement(1073688..1074203) Streptococcus pneumoniae R6 933958 NP_358669.1 CDS lacA NC_003098.1 1074234 1074659 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA complement(1074234..1074659) Streptococcus pneumoniae R6 933185 NP_358671.1 CDS spr1078 NC_003098.1 1075330 1075728 R transposase complement(1075330..1075728) Streptococcus pneumoniae R6 933863 NP_358672.1 CDS spr1079 NC_003098.1 1075659 1076180 R hypothetical protein complement(1075659..1076180) Streptococcus pneumoniae R6 934030 NP_358673.1 CDS spr1080 NC_003098.1 1076140 1076442 R hypothetical protein complement(1076140..1076442) Streptococcus pneumoniae R6 933906 NP_358674.1 CDS spr1081 NC_003098.1 1076480 1076752 R hypothetical protein complement(1076480..1076752) Streptococcus pneumoniae R6 932942 YP_008719804.1 CDS spr1079a NC_003098.1 1077136 1077288 D hypothetical protein 1077136..1077288 Streptococcus pneumoniae R6 17374509 NP_358675.1 CDS lepA NC_003098.1 1077369 1079192 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(1077369..1079192) Streptococcus pneumoniae R6 933087 NP_358676.1 CDS pphA NC_003098.1 1079271 1079999 R serine/threonine protein phosphatase complement(1079271..1079999) Streptococcus pneumoniae R6 933792 NP_358677.1 CDS recN NC_003098.1 1080001 1081668 R DNA repair protein RecN complement(1080001..1081668) Streptococcus pneumoniae R6 934047 NP_358678.1 CDS ahrC NC_003098.1 1081675 1082106 R arginine metabolism transcriptional regulator complement(1081675..1082106) Streptococcus pneumoniae R6 933785 NP_358679.1 CDS spr1086 NC_003098.1 1082099 1082914 R Hemolysin-like protein; hypothetical protein complement(1082099..1082914) Streptococcus pneumoniae R6 933503 NP_358680.1 CDS ispA NC_003098.1 1082907 1083782 R geranyltranstransferase complement(1082907..1083782) Streptococcus pneumoniae R6 933371 NP_358681.1 CDS xseB NC_003098.1 1083779 1083991 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(1083779..1083991) Streptococcus pneumoniae R6 933250 NP_358682.1 CDS xseA NC_003098.1 1083969 1085315 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(1083969..1085315) Streptococcus pneumoniae R6 933134 NP_358683.1 CDS udK NC_003098.1 1085437 1086075 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(1085437..1086075) Streptococcus pneumoniae R6 933122 NP_358684.1 CDS spr1091 NC_003098.1 1086183 1086485 R hypothetical protein complement(1086183..1086485) Streptococcus pneumoniae R6 933148 NP_358685.1 CDS truB NC_003098.1 1086726 1087604 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(1086726..1087604) Streptococcus pneumoniae R6 933266 NP_358686.1 CDS spr1093 NC_003098.1 1087705 1090890 R hypothetical protein complement(1087705..1090890) Streptococcus pneumoniae R6 933791 NP_358687.1 CDS spr1094 NC_003098.1 1090902 1092176 R hypothetical protein complement(1090902..1092176) Streptococcus pneumoniae R6 933072 NP_358690.1 CDS nirC NC_003098.1 1093679 1094476 R formate/nitrate transporter complement(1093679..1094476) Streptococcus pneumoniae R6 934032 NP_358691.1 CDS srtA NC_003098.1 1094720 1095463 R proposed to perform the peptide cleavage and the transpeptidation during the process of anchoring proteins to Gram-positive bacterial cell walls; sortase complement(1094720..1095463) Streptococcus pneumoniae R6 933969 NP_358692.1 CDS gyrA NC_003098.1 1095463 1097931 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(1095463..1097931) Streptococcus pneumoniae R6 933198 NP_358693.1 CDS ldh NC_003098.1 1098125 1099111 D Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1098125..1099111 Streptococcus pneumoniae R6 933245 NP_358694.1 CDS spnII-interrupted-C NC_003098.1 1099497 1102751 R type II restriction endonuclease complement(1099497..1102751) Streptococcus pneumoniae R6 933928 NP_358695.1 CDS spnII-interrupted-N NC_003098.1 1102916 1104793 R type II restriction endonuclease complement(1102916..1104793) Streptococcus pneumoniae R6 933783 NP_358696.1 CDS spr1103 NC_003098.1 1104862 1105125 R hypothetical protein complement(1104862..1105125) Streptococcus pneumoniae R6 933412 NP_358697.1 CDS spr1104 NC_003098.1 1105118 1105420 R hypothetical protein complement(1105118..1105420) Streptococcus pneumoniae R6 933121 NP_358698.1 CDS vicX NC_003098.1 1105451 1106260 R metal-dependent hydrolase complement(1105451..1106260) Streptococcus pneumoniae R6 933337 NP_358699.1 CDS hk02 NC_003098.1 1106262 1107611 R sensory box sensor histidine kinase complement(1106262..1107611) Streptococcus pneumoniae R6 933765 NP_358700.1 CDS rr02 NC_003098.1 1107604 1108359 R DNA-binding response regulator complement(1107604..1108359) Streptococcus pneumoniae R6 932912 NP_358701.1 CDS mutY NC_003098.1 1108363 1109538 R A/G-specific adenine glycosylase complement(1108363..1109538) Streptococcus pneumoniae R6 933900 NP_358702.1 CDS fhs NC_003098.1 1109867 1111537 R catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase complement(1109867..1111537) Streptococcus pneumoniae R6 933045 NP_358703.1 CDS dfp-C-terminus NC_003098.1 1111752 1112456 D phosphopantothenate--cysteine ligase 1111752..1112456 Streptococcus pneumoniae R6 933205 NP_358704.1 CDS dfp-N-terminus NC_003098.1 1112468 1113019 D decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 1112468..1113019 Streptococcus pneumoniae R6 933762 NP_358705.1 CDS spr1112 NC_003098.1 1113003 1113566 D Probable membrane protein; hypothetical protein 1113003..1113566 Streptococcus pneumoniae R6 932957 NP_358706.1 CDS spr1113 NC_003098.1 1113794 1114375 D hypothetical protein 1113794..1114375 Streptococcus pneumoniae R6 933218 NP_358707.1 CDS spr1114 NC_003098.1 1114387 1114902 D Probable transcriptional regulator; hypothetical protein 1114387..1114902 Streptococcus pneumoniae R6 932954 NP_358708.1 CDS spr1115 NC_003098.1 1114899 1115366 R MutT-like protein; hypothetical protein complement(1114899..1115366) Streptococcus pneumoniae R6 932945 NP_358709.1 CDS spr1116 NC_003098.1 1115440 1115928 R Acetyltransferase (GNAT) family; hypothetical protein complement(1115440..1115928) Streptococcus pneumoniae R6 933162 NP_358710.1 CDS spr1117 NC_003098.1 1115894 1116457 R Probable acetyltransferase; hypothetical protein complement(1115894..1116457) Streptococcus pneumoniae R6 933313 NP_358711.1 CDS uvrB NC_003098.1 1116467 1118455 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B complement(1116467..1118455) Streptococcus pneumoniae R6 933244 NP_358712.1 CDS spr1119 NC_003098.1 1118532 1119485 R transmembrane protein; hypothetical protein complement(1118532..1119485) Streptococcus pneumoniae R6 933140 NP_358713.1 CDS glnP NC_003098.1 1119658 1121823 D amino acid ABC transporter substrate-binding protein 1119658..1121823 Streptococcus pneumoniae R6 934028 NP_358714.1 CDS glnQ NC_003098.1 1121823 1122563 D amino acid ABC transporter ATP-binding protein 1121823..1122563 Streptococcus pneumoniae R6 933796 NP_358715.1 CDS zwf NC_003098.1 1122712 1124199 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1122712..1124199 Streptococcus pneumoniae R6 933288 NP_358716.1 CDS ftsY NC_003098.1 1124245 1125522 R signal recognition particle-docking protein FtsY complement(1124245..1125522) Streptococcus pneumoniae R6 933257 NP_358717.1 CDS spr1124 NC_003098.1 1125526 1126344 R Cof family protein complement(1125526..1126344) Streptococcus pneumoniae R6 933814 NP_358718.1 CDS spr1125 NC_003098.1 1126344 1127138 R Cof family protein complement(1126344..1127138) Streptococcus pneumoniae R6 933655 NP_358719.1 CDS smc NC_003098.1 1127135 1130674 R chromosome condensation and segregation SMC protein complement(1127135..1130674) Streptococcus pneumoniae R6 933157 NP_358720.1 CDS rnc NC_003098.1 1130665 1131363 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(1130665..1131363) Streptococcus pneumoniae R6 932926 NP_358721.1 CDS guaC NC_003098.1 1131681 1132667 R guanosine 5'-monophosphate oxidoreductase complement(1131681..1132667) Streptococcus pneumoniae R6 933293 NP_358722.1 CDS spr1129 NC_003098.1 1132842 1134185 R hypothetical protein complement(1132842..1134185) Streptococcus pneumoniae R6 932798 NP_358723.1 CDS spr1130 NC_003098.1 1134145 1136079 R Probable endonuclease; endonuclease complement(1134145..1136079) Streptococcus pneumoniae R6 933897 NP_358724.1 CDS spr1131 NC_003098.1 1136240 1136410 R hypothetical protein complement(1136240..1136410) Streptococcus pneumoniae R6 933326 NP_358725.1 CDS spr1132 NC_003098.1 1136391 1136564 R hypothetical protein complement(1136391..1136564) Streptococcus pneumoniae R6 932830 NP_358727.1 CDS spr1134 NC_003098.1 1137389 1137658 R hypothetical protein complement(1137389..1137658) Streptococcus pneumoniae R6 932826 NP_358728.1 CDS leuB NC_003098.1 1137655 1138692 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(1137655..1138692) Streptococcus pneumoniae R6 933207 NP_358731.1 CDS spr1138 NC_003098.1 1139817 1140473 R hypothetical protein complement(1139817..1140473) Streptococcus pneumoniae R6 933271 NP_358732.1 CDS cutC NC_003098.1 1140517 1141149 R copper homeostasis protein CutC complement(1140517..1141149) Streptococcus pneumoniae R6 932966 NP_358733.1 CDS spr1140 NC_003098.1 1141242 1141601 R hypothetical protein complement(1141242..1141601) Streptococcus pneumoniae R6 933904 NP_358734.1 CDS topA NC_003098.1 1141707 1143812 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(1141707..1143812) Streptococcus pneumoniae R6 933880 NP_358735.1 CDS spr1142 NC_003098.1 1143961 1145004 R hypothetical protein complement(1143961..1145004) Streptococcus pneumoniae R6 933253 NP_358737.1 CDS smf NC_003098.1 1145894 1146754 R Also known as Competence induced loci B, CilB; DNA processing protein DprA complement(1145894..1146754) Streptococcus pneumoniae R6 933320 NP_358738.1 CDS licC NC_003098.1 1146838 1147527 R hypothetical protein complement(1146838..1147527) Streptococcus pneumoniae R6 933831 NP_358739.1 CDS licB NC_003098.1 1147539 1148429 R hypothetical protein complement(1147539..1148429) Streptococcus pneumoniae R6 933852 NP_358740.1 CDS pck NC_003098.1 1148407 1149276 R choline kinase complement(1148407..1149276) Streptococcus pneumoniae R6 933258 NP_358741.1 CDS spr1148 NC_003098.1 1149293 1150333 R Probable oxidoreductase; zinc-containing alcohol dehydrogenase complement(1149293..1150333) Streptococcus pneumoniae R6 932935 NP_358742.1 CDS ispD NC_003098.1 1150320 1151027 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(1150320..1151027) Streptococcus pneumoniae R6 933316 NP_358743.1 CDS spr1150 NC_003098.1 1151363 1152850 D Probable oligosaccharide repeat unit transporter; polysaccharide biosynthesis protein 1151363..1152850 Streptococcus pneumoniae R6 933321 NP_358744.1 CDS licD1 NC_003098.1 1152860 1153663 D required for phosphorylcholine incorporation in teichoic and lipoteichoic acids 1152860..1153663 Streptococcus pneumoniae R6 933252 NP_358745.1 CDS licD2 NC_003098.1 1153665 1154474 D Required for phosphorylcholine incorporation in teichoic and lipoteichoic acids; licD protein 1153665..1154474 Streptococcus pneumoniae R6 933341 NP_358746.1 CDS carB NC_003098.1 1154749 1157925 R four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit complement(1154749..1157925) Streptococcus pneumoniae R6 933355 NP_358747.1 CDS carA NC_003098.1 1158238 1159317 R catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit complement(1158238..1159317) Streptococcus pneumoniae R6 933238 NP_358748.1 CDS pyrB NC_003098.1 1159367 1160290 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase complement(1159367..1160290) Streptococcus pneumoniae R6 933189 NP_358749.1 CDS pyrR NC_003098.1 1160309 1160830 R regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase complement(1160309..1160830) Streptococcus pneumoniae R6 933441 NP_358750.1 CDS nth NC_003098.1 1161041 1161670 R endonuclease III complement(1161041..1161670) Streptococcus pneumoniae R6 933279 NP_358751.1 CDS spr1158 NC_003098.1 1161670 1162212 R hypothetical protein complement(1161670..1162212) Streptococcus pneumoniae R6 933191 NP_358754.1 CDS ABC-NBD NC_003098.1 1162971 1164497 D ABC transporter ATP-binding protein 1162971..1164497 Streptococcus pneumoniae R6 933416 NP_358755.1 CDS htpX NC_003098.1 1164646 1165554 R metalloprotease; heat shock protein HtpX complement(1164646..1165554) Streptococcus pneumoniae R6 932914 NP_358756.1 CDS lemA NC_003098.1 1165547 1166107 R cytoplasmic membrane protein complement(1165547..1166107) Streptococcus pneumoniae R6 934068 NP_358757.1 CDS gidB NC_003098.1 1166177 1166914 D glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1166177..1166914 Streptococcus pneumoniae R6 933340 NP_358758.1 CDS pyrP NC_003098.1 1167230 1168549 D uracil permease 1167230..1168549 Streptococcus pneumoniae R6 933249 NP_358759.1 CDS ffh NC_003098.1 1168744 1170315 R signal recognition particle protein complement(1168744..1170315) Streptococcus pneumoniae R6 933912 NP_358760.1 CDS spr1167 NC_003098.1 1170327 1170659 R DNA-binding protein complement(1170327..1170659) Streptococcus pneumoniae R6 932921 NP_358761.1 CDS spr1168 NC_003098.1 1170750 1171127 R hypothetical protein complement(1170750..1171127) Streptococcus pneumoniae R6 933175 NP_358762.1 CDS spr1169 NC_003098.1 1171103 1172503 D hypothetical protein 1171103..1172503 Streptococcus pneumoniae R6 933220 NP_358763.1 CDS spr1170 NC_003098.1 1172516 1173322 D Cof family protein 1172516..1173322 Streptococcus pneumoniae R6 933184 NP_358764.1 CDS rplS NC_003098.1 1173490 1173837 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(1173490..1173837) Streptococcus pneumoniae R6 932995 NP_358765.1 CDS crcB NC_003098.1 1173956 1174285 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1173956..1174285) Streptococcus pneumoniae R6 933959 NP_358766.1 CDS crcB NC_003098.1 1174279 1174653 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1174279..1174653) Streptococcus pneumoniae R6 934163 NP_358767.1 CDS spr1174 NC_003098.1 1174650 1174916 R hypothetical protein complement(1174650..1174916) Streptococcus pneumoniae R6 933949 NP_358768.1 CDS flaV NC_003098.1 1175032 1175475 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(1175032..1175475) Streptococcus pneumoniae R6 933952 NP_358769.1 CDS spr1176 NC_003098.1 1175567 1176514 D DHH subfamily 1 protein 1175567..1176514 Streptococcus pneumoniae R6 933806 NP_358770.1 CDS rpmE2 NC_003098.1 1176610 1176852 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1176610..1176852 Streptococcus pneumoniae R6 933825 NP_358771.1 CDS spr1178 NC_003098.1 1176909 1177487 R hypothetical protein complement(1176909..1177487) Streptococcus pneumoniae R6 933834 NP_358772.1 CDS spr1179 NC_003098.1 1177462 1178466 R hypothetical protein complement(1177462..1178466) Streptococcus pneumoniae R6 933059 NP_358774.1 CDS gdhA NC_003098.1 1179472 1180818 D converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1179472..1180818 Streptococcus pneumoniae R6 934142 NP_358775.1 CDS spr1182 NC_003098.1 1181314 1181484 R hypothetical protein complement(1181314..1181484) Streptococcus pneumoniae R6 934144 NP_358776.1 CDS spr1183 NC_003098.1 1181497 1182138 R ABC transporter ATP-binding protein complement(1181497..1182138) Streptococcus pneumoniae R6 934145 NP_358778.1 CDS spr1185 NC_003098.1 1183138 1183341 R hypothetical protein complement(1183138..1183341) Streptococcus pneumoniae R6 934148 NP_358781.1 CDS cdd NC_003098.1 1184308 1184715 R cytidine deaminase complement(1184308..1184715) Streptococcus pneumoniae R6 934151 NP_358782.1 CDS spr1189 NC_003098.1 1185003 1185491 R hypothetical protein complement(1185003..1185491) Streptococcus pneumoniae R6 934152 NP_358783.1 CDS spr1190 NC_003098.1 1185496 1186914 R hypothetical protein complement(1185496..1186914) Streptococcus pneumoniae R6 934153 NP_358784.1 CDS appD NC_003098.1 1186915 1188897 R peptide ABC transporter ATP-binding protein complement(1186915..1188897) Streptococcus pneumoniae R6 934155 NP_358785.1 CDS appC NC_003098.1 1188910 1189761 R peptide ABC transporter permease complement(1188910..1189761) Streptococcus pneumoniae R6 934156 NP_358786.1 CDS appB NC_003098.1 1189778 1190773 R peptide ABC transporter permease complement(1189778..1190773) Streptococcus pneumoniae R6 934157 NP_358787.1 CDS appA NC_003098.1 1190838 1192466 R oligopeptide ABC transporter substrate-binding protein complement(1190838..1192466) Streptococcus pneumoniae R6 934158 NP_358788.1 CDS spr1195 NC_003098.1 1192548 1193471 R hypothetical protein complement(1192548..1193471) Streptococcus pneumoniae R6 932793 NP_358789.1 CDS nanE NC_003098.1 1193495 1194193 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(1193495..1194193) Streptococcus pneumoniae R6 934409 NP_358792.1 CDS spr1199 NC_003098.1 1195086 1195307 R hypothetical protein complement(1195086..1195307) Streptococcus pneumoniae R6 934412 NP_358794.1 CDS spr1201 NC_003098.1 1196371 1197690 R hypothetical protein complement(1196371..1197690) Streptococcus pneumoniae R6 934413 NP_358795.1 CDS ABC-NDB NC_003098.1 1197693 1198451 R ABC transporter ATP-binding protein complement(1197693..1198451) Streptococcus pneumoniae R6 934415 NP_358796.1 CDS ABC-NP NC_003098.1 1198448 1200055 R drug efflux ABC transporter ATP-binding/permease complement(1198448..1200055) Streptococcus pneumoniae R6 934427 NP_358797.1 CDS ptrB NC_003098.1 1200052 1201992 R prolyl oligopeptidase complement(1200052..1201992) Streptococcus pneumoniae R6 934419 NP_358798.1 CDS spr1205 NC_003098.1 1202025 1204661 R hypothetical protein complement(1202025..1204661) Streptococcus pneumoniae R6 934416 NP_358799.1 CDS spr1206 NC_003098.1 1205152 1205739 R hypothetical protein complement(1205152..1205739) Streptococcus pneumoniae R6 934423 NP_358800.1 CDS spr1207 NC_003098.1 1205988 1206368 R hypothetical protein complement(1205988..1206368) Streptococcus pneumoniae R6 934417 NP_358801.1 CDS spr1208 NC_003098.1 1206423 1206701 R hypothetical protein complement(1206423..1206701) Streptococcus pneumoniae R6 934418 NP_358802.1 CDS spr1209 NC_003098.1 1206709 1206963 R hypothetical protein complement(1206709..1206963) Streptococcus pneumoniae R6 934425 NP_358803.1 CDS spr1210 NC_003098.1 1206960 1207172 R hypothetical protein complement(1206960..1207172) Streptococcus pneumoniae R6 934420 NP_358804.2 CDS rplL NC_003098.1 1207321 1207689 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(1207321..1207689) Streptococcus pneumoniae R6 934421 NP_358805.1 CDS rplJ NC_003098.1 1207765 1208265 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(1207765..1208265) Streptococcus pneumoniae R6 934429 NP_358807.2 CDS trzA NC_003098.1 1208515 1209831 R chlorohydrolase complement(1208515..1209831) Streptococcus pneumoniae R6 934426 NP_358808.1 CDS ABC-N/P NC_003098.1 1210076 1211866 R ABC transporter ATP-binding protein/permease complement(1210076..1211866) Streptococcus pneumoniae R6 934428 NP_358809.1 CDS ABC-N/P NC_003098.1 1211829 1213553 R ABC transporter ATP-binding protein/permease complement(1211829..1213553) Streptococcus pneumoniae R6 934430 NP_358810.1 CDS msrA NC_003098.1 1213611 1214549 R this fusion consists of methionine sulfoxide A reductase at the N-terminus and B at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion; bifunctional methionine sulfoxide reductase A/B protein complement(1213611..1214549) Streptococcus pneumoniae R6 934434 NP_358811.1 CDS thrB NC_003098.1 1214845 1215714 R catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase complement(1214845..1215714) Streptococcus pneumoniae R6 934431 NP_358812.2 CDS hom NC_003098.1 1215716 1217002 R catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase complement(1215716..1217002) Streptococcus pneumoniae R6 934437 NP_358813.1 CDS mecA NC_003098.1 1217153 1217890 R enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein complement(1217153..1217890) Streptococcus pneumoniae R6 934432 NP_358814.1 CDS spr1221 NC_003098.1 1218032 1219066 R hypothetical protein complement(1218032..1219066) Streptococcus pneumoniae R6 934433 NP_358815.1 CDS spr1222 NC_003098.1 1219095 1220528 R hypothetical protein complement(1219095..1220528) Streptococcus pneumoniae R6 934447 NP_358816.1 CDS cps23FU NC_003098.1 1220544 1221530 R galactosyl transferase complement(1220544..1221530) Streptococcus pneumoniae R6 934436 NP_358817.1 CDS spr1224 NC_003098.1 1221532 1222689 R Similar to capsular polysaccharide biosynthsis protein; hypothetical protein complement(1221532..1222689) Streptococcus pneumoniae R6 934444 NP_358818.1 CDS licD1 NC_003098.1 1222625 1223470 R licD protein complement(1222625..1223470) Streptococcus pneumoniae R6 934441 NP_358819.1 CDS spr1226 NC_003098.1 1223749 1225023 R transcriptional regulator; hypothetical protein complement(1223749..1225023) Streptococcus pneumoniae R6 934438 NP_358820.1 CDS pheA NC_003098.1 1225020 1225868 R catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase complement(1225020..1225868) Streptococcus pneumoniae R6 934451 NP_358821.1 CDS aroK NC_003098.1 1225865 1226341 R shikimate kinase complement(1225865..1226341) Streptococcus pneumoniae R6 934443 NP_358822.1 CDS aroA NC_003098.1 1226334 1227629 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(1226334..1227629) Streptococcus pneumoniae R6 934439 NP_358823.1 CDS spr1230 NC_003098.1 1227709 1228047 R hypothetical protein complement(1227709..1228047) Streptococcus pneumoniae R6 934450 NP_358824.1 CDS tyrA NC_003098.1 1228058 1229161 R catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase complement(1228058..1229161) Streptococcus pneumoniae R6 934440 NP_358825.1 CDS aroC NC_003098.1 1229171 1230337 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(1229171..1230337) Streptococcus pneumoniae R6 934448 NP_358826.1 CDS aroB NC_003098.1 1230347 1231414 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(1230347..1231414) Streptococcus pneumoniae R6 934442 NP_358827.1 CDS aroE NC_003098.1 1231433 1232287 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(1231433..1232287) Streptococcus pneumoniae R6 934445 NP_358828.1 CDS aroD NC_003098.1 1232277 1232954 R catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase complement(1232277..1232954) Streptococcus pneumoniae R6 934452 NP_358829.1 CDS spr1236 NC_003098.1 1232951 1234123 R hypothetical protein complement(1232951..1234123) Streptococcus pneumoniae R6 934468 NP_358830.1 CDS spr1237 NC_003098.1 1234801 1236462 R hypothetical protein complement(1234801..1236462) Streptococcus pneumoniae R6 934446 NP_358831.1 CDS ABC-NBD NC_003098.1 1236416 1237222 R ABC transporter ATP-binding protein complement(1236416..1237222) Streptococcus pneumoniae R6 934455 NP_358832.1 CDS amy NC_003098.1 1237343 1238797 D converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 1237343..1238797 Streptococcus pneumoniae R6 934449 NP_358833.1 CDS alaS NC_003098.1 1238887 1241505 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(1238887..1241505) Streptococcus pneumoniae R6 934453 NP_358834.1 CDS spr1241 NC_003098.1 1241527 1242024 R hypothetical protein complement(1241527..1242024) Streptococcus pneumoniae R6 934456 NP_358835.1 CDS spr1242 NC_003098.1 1242287 1242526 R hypothetical protein complement(1242287..1242526) Streptococcus pneumoniae R6 934454 NP_358836.1 CDS potD NC_003098.1 1242787 1243857 R spermidine/putrescine ABC transporter substrate-binding protein complement(1242787..1243857) Streptococcus pneumoniae R6 934459 NP_358837.1 CDS potC NC_003098.1 1243854 1244627 R spermidine/putrescine ABC transporter permease complement(1243854..1244627) Streptococcus pneumoniae R6 934457 NP_358838.1 CDS potB NC_003098.1 1244624 1245451 R spermidine/putrescine ABC transporter permease complement(1244624..1245451) Streptococcus pneumoniae R6 934458 NP_358839.1 CDS potA NC_003098.1 1245411 1246568 R spermidine/putrescine ABC transporter ATP-binding protein complement(1245411..1246568) Streptococcus pneumoniae R6 934460 NP_358840.1 CDS murB NC_003098.1 1246627 1247577 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(1246627..1247577) Streptococcus pneumoniae R6 934461 NP_358841.1 CDS spr1248 NC_003098.1 1247689 1248441 R hypothetical protein complement(1247689..1248441) Streptococcus pneumoniae R6 934464 NP_358842.1 CDS aldB NC_003098.1 1248451 1249182 R alpha-acetolactate decarboxylase complement(1248451..1249182) Streptococcus pneumoniae R6 934465 NP_358843.1 CDS spr1250 NC_003098.1 1249324 1250595 D hypothetical protein 1249324..1250595 Streptococcus pneumoniae R6 934462 NP_358844.1 CDS glnH NC_003098.1 1250615 1251430 R amino acid ABC transporter amino acid-binding protein complement(1250615..1251430) Streptococcus pneumoniae R6 934463 NP_358845.1 CDS phoU NC_003098.1 1251587 1252240 R phosphate transporter PhoU complement(1251587..1252240) Streptococcus pneumoniae R6 934483 NP_358846.1 CDS pstB NC_003098.1 1252252 1253010 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1252252..1253010) Streptococcus pneumoniae R6 934467 NP_358847.1 CDS pstB NC_003098.1 1253023 1253826 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1253023..1253826) Streptococcus pneumoniae R6 934466 NP_358848.1 CDS pstA NC_003098.1 1253837 1254721 R phosphate ABC transporter permease complement(1253837..1254721) Streptococcus pneumoniae R6 934472 NP_358849.1 CDS pstC NC_003098.1 1254711 1255628 R phosphate ABC transporter permease complement(1254711..1255628) Streptococcus pneumoniae R6 934470 NP_358850.1 CDS pstS NC_003098.1 1255628 1256506 R phosphate ABC transporter substrate+B766-binding protein complement(1255628..1256506) Streptococcus pneumoniae R6 934469 NP_358853.1 CDS spr1260 NC_003098.1 1258385 1259233 R Similar to E. coli extragenic suppressor protein SuhB; inositol monophosphatase complement(1258385..1259233) Streptococcus pneumoniae R6 934476 NP_358854.1 CDS spr1261 NC_003098.1 1259148 1259426 R hypothetical protein complement(1259148..1259426) Streptococcus pneumoniae R6 934481 NP_358855.1 CDS spxA NC_003098.1 1259426 1259827 R the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx complement(1259426..1259827) Streptococcus pneumoniae R6 934475 NP_358856.1 CDS spr1263 NC_003098.1 1260037 1260687 R hypothetical protein complement(1260037..1260687) Streptococcus pneumoniae R6 934478 NP_358857.1 CDS nagD NC_003098.1 1260644 1261417 R N-acetyl-glucosamine matabolism complement(1260644..1261417) Streptococcus pneumoniae R6 934502 NP_358858.1 CDS spr1265 NC_003098.1 1261428 1262165 R Acyl-ACP thioesterase; acyl-ACP thioesterase complement(1261428..1262165) Streptococcus pneumoniae R6 934474 NP_358859.1 CDS hemN NC_003098.1 1262170 1263300 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(1262170..1263300) Streptococcus pneumoniae R6 934487 NP_358860.1 CDS spr1267 NC_003098.1 1263384 1263773 R hypothetical protein complement(1263384..1263773) Streptococcus pneumoniae R6 934477 NP_358861.1 CDS spr1268 NC_003098.1 1263789 1264172 R hypothetical protein complement(1263789..1264172) Streptococcus pneumoniae R6 934479 NP_358862.1 CDS lgt NC_003098.1 1264173 1264973 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(1264173..1264973) Streptococcus pneumoniae R6 934486 NP_358863.1 CDS hprK NC_003098.1 1264954 1265904 R catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase complement(1264954..1265904) Streptococcus pneumoniae R6 934482 NP_358864.1 CDS rpsU NC_003098.1 1266019 1266219 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(1266019..1266219) Streptococcus pneumoniae R6 934480 NP_358865.1 CDS nagB NC_003098.1 1266335 1267057 R glucosamine-6-phosphate isomerase complement(1266335..1267057) Streptococcus pneumoniae R6 934489 NP_358866.1 CDS queA NC_003098.1 1267181 1268221 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 1267181..1268221 Streptococcus pneumoniae R6 934484 NP_358868.1 CDS spr1275 NC_003098.1 1270613 1271164 R alanine acetyl transferase; hypothetical protein complement(1270613..1271164) Streptococcus pneumoniae R6 934485 NP_358869.1 CDS nadE NC_003098.1 1271411 1272235 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1271411..1272235) Streptococcus pneumoniae R6 934488 NP_358870.1 CDS spr1277 NC_003098.1 1272232 1273692 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1272232..1273692) Streptococcus pneumoniae R6 934497 NP_358871.1 CDS spr1278 NC_003098.1 1273808 1274296 R hypothetical protein complement(1273808..1274296) Streptococcus pneumoniae R6 934492 NP_358872.1 CDS spr1279 NC_003098.1 1274286 1274525 R transcription regulator; transcriptional repressor complement(1274286..1274525) Streptococcus pneumoniae R6 934498 NP_358873.1 CDS spr1280 NC_003098.1 1274880 1275608 R hypothetical protein complement(1274880..1275608) Streptococcus pneumoniae R6 934501 NP_358874.1 CDS ABC-NBD NC_003098.1 1275624 1276346 R ABC transporter ATP-binding protein complement(1275624..1276346) Streptococcus pneumoniae R6 934500 NP_358875.1 CDS spr1282 NC_003098.1 1276851 1277576 R hypothetical protein complement(1276851..1277576) Streptococcus pneumoniae R6 934491 NP_358877.1 CDS spr1284 NC_003098.1 1278165 1279469 R protease complement(1278165..1279469) Streptococcus pneumoniae R6 934494 NP_358881.1 CDS spr1288 NC_003098.1 1282334 1283326 R hypothetical protein complement(1282334..1283326) Streptococcus pneumoniae R6 934499 NP_358882.1 CDS ABC-N/P NC_003098.1 1283480 1285240 D ABC transporter ATP-binding protein/permease 1283480..1285240 Streptococcus pneumoniae R6 934506 NP_358883.1 CDS ABC-N/P NC_003098.1 1285200 1286945 D ABC transporter ATP-binding protein 1285200..1286945 Streptococcus pneumoniae R6 934504 NP_358884.1 CDS spr1291 NC_003098.1 1286956 1287540 D hypothetical protein 1286956..1287540 Streptococcus pneumoniae R6 934511 NP_358885.1 CDS spr1292 NC_003098.1 1287540 1288235 D hypothetical protein 1287540..1288235 Streptococcus pneumoniae R6 934527 NP_358886.1 CDS ABC-NBD NC_003098.1 1288223 1289587 D ABC transporter ATP-binding protein 1288223..1289587 Streptococcus pneumoniae R6 934510 NP_358887.1 CDS spr1294 NC_003098.1 1290375 1290836 R hypothetical protein complement(1290375..1290836) Streptococcus pneumoniae R6 934512 NP_358889.1 CDS spr1296 NC_003098.1 1291130 1291498 R hypothetical protein complement(1291130..1291498) Streptococcus pneumoniae R6 934507 NP_358890.1 CDS spr1297 NC_003098.1 1291422 1291616 R hypothetical protein complement(1291422..1291616) Streptococcus pneumoniae R6 934513 NP_358891.1 CDS transposase_E NC_003098.1 1291786 1292136 R transposase complement(1291786..1292136) Streptococcus pneumoniae R6 934509 NP_358893.1 CDS guaA NC_003098.1 1292606 1294168 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(1292606..1294168) Streptococcus pneumoniae R6 934514 NP_358894.1 CDS spr1301 NC_003098.1 1294301 1295008 D Probable transcription regulator, GntR family; hypothetical protein 1294301..1295008 Streptococcus pneumoniae R6 934515 NP_358895.1 CDS spr1302 NC_003098.1 1295051 1296007 R membrane protein; hypothetical protein complement(1295051..1296007) Streptococcus pneumoniae R6 934519 NP_358896.1 CDS spr1303 NC_003098.1 1295956 1296894 R hypothetical protein complement(1295956..1296894) Streptococcus pneumoniae R6 934520 NP_358897.1 CDS cppA NC_003098.1 1296891 1297631 R C3-degrading proteinase complement(1296891..1297631) Streptococcus pneumoniae R6 934516 NP_358898.1 CDS spr1305 NC_003098.1 1297700 1298335 R hypothetical protein complement(1297700..1298335) Streptococcus pneumoniae R6 934524 NP_358899.1 CDS spr1306 NC_003098.1 1298337 1299164 R Cof family protein complement(1298337..1299164) Streptococcus pneumoniae R6 934518 NP_358903.1 CDS def NC_003098.1 1300763 1301374 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1300763..1301374 Streptococcus pneumoniae R6 934523 NP_358904.1 CDS trmH NC_003098.1 1301386 1302147 D tRNA (guanosine-2'-O-)-methyltransferase 1301386..1302147 Streptococcus pneumoniae R6 934536 NP_358905.1 CDS trxB NC_003098.1 1302186 1303097 R thioredoxin reductase complement(1302186..1303097) Streptococcus pneumoniae R6 934526 NP_358906.1 CDS spr1313 NC_003098.1 1303163 1303399 R hypothetical protein complement(1303163..1303399) Streptococcus pneumoniae R6 934525 NP_358907.1 CDS ABC-NDB NC_003098.1 1303465 1304208 R amino acid ABC transporter ATP-binding protein complement(1303465..1304208) Streptococcus pneumoniae R6 934534 NP_358908.1 CDS ABC-MSP NC_003098.1 1304208 1305008 R amino acid ABC transporter permease complement(1304208..1305008) Streptococcus pneumoniae R6 934533 NP_358909.1 CDS spr1316 NC_003098.1 1305166 1305522 R Similar to arsenate reductase; hypothetical protein complement(1305166..1305522) Streptococcus pneumoniae R6 934529 NP_358910.1 CDS ogt NC_003098.1 1305516 1306046 R methylated-DNA--protein-cysteine S-methyltransferase complement(1305516..1306046) Streptococcus pneumoniae R6 934535 NP_358911.1 CDS spr1318 NC_003098.1 1306046 1306540 R acetyltransferase; hypothetical protein complement(1306046..1306540) Streptococcus pneumoniae R6 934530 NP_358912.1 CDS spr1319 NC_003098.1 1306669 1307121 D hypothetical protein 1306669..1307121 Streptococcus pneumoniae R6 934531 NP_358913.1 CDS spr1320 NC_003098.1 1307118 1307765 D Similar to hemolysin III; hemolysin 1307118..1307765 Streptococcus pneumoniae R6 934541 NP_358914.1 CDS spr1321 NC_003098.1 1307786 1308367 R with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT complement(1307786..1308367) Streptococcus pneumoniae R6 934544 NP_358915.1 CDS pdx1 NC_003098.1 1308368 1309261 R with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS complement(1308368..1309261) Streptococcus pneumoniae R6 934532 NP_358916.1 CDS nox NC_003098.1 1309395 1310774 R NADH oxidase complement(1309395..1310774) Streptococcus pneumoniae R6 934540 NP_358917.1 CDS apbE NC_003098.1 1311068 1311991 D thiamine biosynthesis protein ApbE 1311068..1311991 Streptococcus pneumoniae R6 934537 NP_358918.1 CDS spr1325 NC_003098.1 1312051 1312656 D hypothetical protein 1312051..1312656 Streptococcus pneumoniae R6 934542 NP_358919.1 CDS spr1326 NC_003098.1 1312674 1313918 D oxidoreductase 1312674..1313918 Streptococcus pneumoniae R6 934543 NP_358920.1 CDS spr1327 NC_003098.1 1314035 1314292 R hypothetical protein complement(1314035..1314292) Streptococcus pneumoniae R6 934539 NP_358921.1 CDS glyS NC_003098.1 1314334 1316370 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(1314334..1316370) Streptococcus pneumoniae R6 934538 NP_358922.1 CDS glyQ NC_003098.1 1316630 1317547 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(1316630..1317547) Streptococcus pneumoniae R6 934548 NP_358925.1 CDS spr1332 NC_003098.1 1318774 1319616 R oxidoreductase; hypothetical protein complement(1318774..1319616) Streptococcus pneumoniae R6 934550 NP_358926.1 CDS pgdA NC_003098.1 1319730 1321121 R peptidoglycan GlcNAc deacetylase complement(1319730..1321121) Streptococcus pneumoniae R6 934547 NP_358928.1 CDS mocA NC_003098.1 1321864 1322925 D oxidoreductase 1321864..1322925 Streptococcus pneumoniae R6 934555 NP_358929.1 CDS DEAD/H NC_003098.1 1322922 1324004 D DEAD RNA helicase 1322922..1324004 Streptococcus pneumoniae R6 934554 NP_358936.1 CDS tuf NC_003098.1 1326964 1328160 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(1326964..1328160) Streptococcus pneumoniae R6 934560 NP_358937.1 CDS glpF NC_003098.1 1329082 1329951 R glycerol uptake facilitator protein complement(1329082..1329951) Streptococcus pneumoniae R6 934564 NP_358938.1 CDS spr1345 NC_003098.1 1330175 1330783 R cell wall surface anchor family protein complement(1330175..1330783) Streptococcus pneumoniae R6 934589 NP_358939.1 CDS spr1346 NC_003098.1 1330741 1331853 R hypothetical protein complement(1330741..1331853) Streptococcus pneumoniae R6 934559 NP_358940.1 CDS spr1347 NC_003098.1 1331958 1332212 R hypothetical protein complement(1331958..1332212) Streptococcus pneumoniae R6 934567 NP_358941.1 CDS spr1348 NC_003098.1 1332206 1332448 R hypothetical protein complement(1332206..1332448) Streptococcus pneumoniae R6 934562 NP_358944.1 CDS pgm NC_003098.1 1333648 1335366 D phosphoglucomutase 1333648..1335366 Streptococcus pneumoniae R6 934575 NP_358945.1 CDS bta NC_003098.1 1335477 1335824 D bacterocin transport accessory protein 1335477..1335824 Streptococcus pneumoniae R6 934565 NP_358946.1 CDS glnH NC_003098.1 1336103 1336939 R amino acid ABC transporter amino acid-binding protein complement(1336103..1336939) Streptococcus pneumoniae R6 934569 NP_358947.1 CDS glnQ NC_003098.1 1336952 1337581 R amino acid ABC transporter ATP-binding protein complement(1336952..1337581) Streptococcus pneumoniae R6 934568 NP_358948.1 CDS glnP NC_003098.1 1337591 1338289 R amino acid ABC transporter permease complement(1337591..1338289) Streptococcus pneumoniae R6 934570 NP_358949.1 CDS spr1356 NC_003098.1 1338378 1339622 R hypothetical protein complement(1338378..1339622) Streptococcus pneumoniae R6 934578 NP_358950.1 CDS spr1357 NC_003098.1 1339597 1340763 R membrane protein; hypothetical protein complement(1339597..1340763) Streptococcus pneumoniae R6 934574 NP_358951.1 CDS spr1358 NC_003098.1 1340907 1341920 D hypothetical protein 1340907..1341920 Streptococcus pneumoniae R6 934572 NP_358952.1 CDS atpC NC_003098.1 1341965 1342384 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon complement(1341965..1342384) Streptococcus pneumoniae R6 934577 NP_358953.1 CDS atpD NC_003098.1 1342395 1343801 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta complement(1342395..1343801) Streptococcus pneumoniae R6 934571 NP_358954.1 CDS atpG NC_003098.1 1343887 1344765 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma complement(1343887..1344765) Streptococcus pneumoniae R6 934573 NP_358955.1 CDS atpA NC_003098.1 1344781 1346286 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha complement(1344781..1346286) Streptococcus pneumoniae R6 934581 NP_358956.1 CDS atpH NC_003098.1 1346301 1346837 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta complement(1346301..1346837) Streptococcus pneumoniae R6 934579 NP_358957.1 CDS atpF NC_003098.1 1346837 1347331 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B complement(1346837..1347331) Streptococcus pneumoniae R6 934576 NP_358958.1 CDS atpB NC_003098.1 1347345 1348061 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A complement(1347345..1348061) Streptococcus pneumoniae R6 934583 NP_358959.1 CDS atpE NC_003098.1 1348096 1348296 R produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C complement(1348096..1348296) Streptococcus pneumoniae R6 934580 NP_358960.1 CDS IS1239 NC_003098.1 1348371 1349378 R transposase complement(1348371..1349378) Streptococcus pneumoniae R6 934582 NP_358961.1 CDS spr1368 NC_003098.1 1349823 1350305 R hypothetical protein complement(1349823..1350305) Streptococcus pneumoniae R6 934587 NP_358962.1 CDS greA NC_003098.1 1350774 1351265 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1350774..1351265) Streptococcus pneumoniae R6 934588 NP_358963.1 CDS spr1370 NC_003098.1 1351327 1352982 R hypothetical protein complement(1351327..1352982) Streptococcus pneumoniae R6 934585 NP_358964.1 CDS spr1371 NC_003098.1 1353063 1353557 R acetyltransferase; hypothetical protein complement(1353063..1353557) Streptococcus pneumoniae R6 934584 NP_358965.1 CDS spr1372 NC_003098.1 1353554 1354018 R N-terminal acetyltransferase related protein; hypothetical protein complement(1353554..1354018) Streptococcus pneumoniae R6 934592 NP_358966.1 CDS murC NC_003098.1 1354028 1355362 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(1354028..1355362) Streptococcus pneumoniae R6 934586 NP_358967.1 CDS spr1374 NC_003098.1 1355373 1355990 R hypothetical protein complement(1355373..1355990) Streptococcus pneumoniae R6 934590 NP_358968.1 CDS snf NC_003098.1 1356038 1359136 R Snf2 family protein complement(1356038..1359136) Streptococcus pneumoniae R6 934596 NP_358969.1 CDS patB NC_003098.1 1359229 1360395 R aminotransferase, class II complement(1359229..1360395) Streptococcus pneumoniae R6 934591 NP_358970.1 CDS metB NC_003098.1 1360403 1361497 R catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase complement(1360403..1361497) Streptococcus pneumoniae R6 934621 NP_358975.1 CDS aliB NC_003098.1 1363510 1365468 R peptide ABC transporter substrate-binding protein complement(1363510..1365468) Streptococcus pneumoniae R6 934595 NP_358976.1 CDS PST_transporter NC_003098.1 1365671 1367293 R polysaccharide biosynthesis protein complement(1365671..1367293) Streptococcus pneumoniae R6 934598 NP_358977.1 CDS murE NC_003098.1 1367399 1368844 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1367399..1368844 Streptococcus pneumoniae R6 934603 NP_358978.1 CDS spr1385 NC_003098.1 1368890 1369084 R hypothetical protein complement(1368890..1369084) Streptococcus pneumoniae R6 934607 NP_358981.1 CDS spr1388 NC_003098.1 1369817 1370329 R hypothetical protein complement(1369817..1370329) Streptococcus pneumoniae R6 934601 NP_358982.1 CDS ppaC NC_003098.1 1370416 1371351 R catalyzes the hydrolysis of pyrophosphate to phosphate; manganese-dependent inorganic pyrophosphatase complement(1370416..1371351) Streptococcus pneumoniae R6 934602 NP_358983.1 CDS spr1390 NC_003098.1 1371422 1371721 R hypothetical protein complement(1371422..1371721) Streptococcus pneumoniae R6 934610 NP_358984.1 CDS spr1391 NC_003098.1 1371711 1372460 R hypothetical protein complement(1371711..1372460) Streptococcus pneumoniae R6 934604 NP_358985.1 CDS spr1392 NC_003098.1 1372514 1372900 R Similar to general stress protein GSP13 from Lactococcus lactis subsp. lactis and Bacillus subtilis; hypothetical protein complement(1372514..1372900) Streptococcus pneumoniae R6 934608 NP_358986.1 CDS spr1393 NC_003098.1 1372875 1374275 R Cof family protein/peptidyl-prolyl cis-trans isomerase complement(1372875..1374275) Streptococcus pneumoniae R6 934612 NP_358987.1 CDS rpsR NC_003098.1 1374570 1374809 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(1374570..1374809) Streptococcus pneumoniae R6 934606 NP_358988.1 CDS ssbA NC_003098.1 1374841 1375311 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1374841..1375311) Streptococcus pneumoniae R6 934609 NP_358989.1 CDS rpsF NC_003098.1 1375323 1375613 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(1375323..1375613) Streptococcus pneumoniae R6 934613 NP_358990.1 CDS asnC NC_003098.1 1375766 1377109 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(1375766..1377109) Streptococcus pneumoniae R6 934611 NP_358991.1 CDS spr1398 NC_003098.1 1377128 1377499 R hypothetical protein complement(1377128..1377499) Streptococcus pneumoniae R6 934615 NP_358992.1 CDS aspB NC_003098.1 1377486 1378673 R catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase complement(1377486..1378673) Streptococcus pneumoniae R6 934622 NP_358993.1 CDS spr1400 NC_003098.1 1378670 1379158 R hypothetical protein complement(1378670..1379158) Streptococcus pneumoniae R6 934614 NP_358995.1 CDS spr1402 NC_003098.1 1379398 1380027 D hypothetical protein 1379398..1380027 Streptococcus pneumoniae R6 934619 NP_358996.1 CDS spr1403 NC_003098.1 1380265 1387920 R hypothetical protein complement(1380265..1387920) Streptococcus pneumoniae R6 934616 NP_358997.1 CDS spr1404 NC_003098.1 1388112 1389620 D Mga-like regulatory protein; hypothetical protein 1388112..1389620 Streptococcus pneumoniae R6 934617 NP_358998.1 CDS spr1405 NC_003098.1 1389671 1390399 R hypothetical protein complement(1389671..1390399) Streptococcus pneumoniae R6 934628 NP_358999.1 CDS spr1406 NC_003098.1 1390478 1390657 R hypothetical protein complement(1390478..1390657) Streptococcus pneumoniae R6 934620 NP_359000.1 CDS spr1407 NC_003098.1 1390809 1392404 R hypothetical protein complement(1390809..1392404) Streptococcus pneumoniae R6 934168 NP_359001.1 CDS def NC_003098.1 1392416 1392826 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(1392416..1392826) Streptococcus pneumoniae R6 934624 NP_359002.1 CDS spr1409 NC_003098.1 1392942 1393733 R YghU; B2989; one of eight glutathione transferases from E. coli; glutathione S-transferase YghU complement(1392942..1393733) Streptococcus pneumoniae R6 934623 NP_359003.1 CDS pacL NC_003098.1 1393746 1396442 R calcium transporter; calcium transporter P-type ATPase complement(1393746..1396442) Streptococcus pneumoniae R6 934079 NP_359004.1 CDS spr1411 NC_003098.1 1396746 1397930 D Probable cation transporter; cation efflux family protein 1396746..1397930 Streptococcus pneumoniae R6 934626 NP_359005.1 CDS ABC-NBD NC_003098.1 1398073 1399944 R ABC transporter ATP-binding protein complement(1398073..1399944) Streptococcus pneumoniae R6 934166 NP_359006.1 CDS cca NC_003098.1 1399941 1401140 R catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase complement(1399941..1401140) Streptococcus pneumoniae R6 934161 NP_359007.1 CDS dapB NC_003098.1 1401137 1401904 R catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase complement(1401137..1401904) Streptococcus pneumoniae R6 934164 NP_359008.1 CDS spr1415 NC_003098.1 1402181 1403029 R Similar to DegV of B.subtilis; hypothetical protein complement(1402181..1403029) Streptococcus pneumoniae R6 934169 NP_359009.1 CDS spr1416 NC_003098.1 1403031 1403417 R hypothetical protein complement(1403031..1403417) Streptococcus pneumoniae R6 933090 NP_359010.1 CDS glmM NC_003098.1 1403479 1404831 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(1403479..1404831) Streptococcus pneumoniae R6 934084 NP_359011.1 CDS spr1418 NC_003098.1 1404855 1405634 R hypothetical protein complement(1404855..1405634) Streptococcus pneumoniae R6 933941 NP_359012.1 CDS spr1419 NC_003098.1 1405621 1406499 R hypothetical protein complement(1405621..1406499) Streptococcus pneumoniae R6 934085 NP_359013.1 CDS spr1420 NC_003098.1 1406396 1406569 R hypothetical protein complement(1406396..1406569) Streptococcus pneumoniae R6 933883 NP_359014.1 CDS trxB NC_003098.1 1406614 1407582 D pyridine nucleotide-disulphide oxidoreductase 1406614..1407582 Streptococcus pneumoniae R6 934042 NP_359015.1 CDS spr1422 NC_003098.1 1407616 1408527 R hypothetical protein complement(1407616..1408527) Streptococcus pneumoniae R6 934044 NP_359016.1 CDS spr1423 NC_003098.1 1408524 1409501 R hypothetical protein complement(1408524..1409501) Streptococcus pneumoniae R6 934065 NP_359017.1 CDS spr1424 NC_003098.1 1409498 1410388 R hypothetical protein complement(1409498..1410388) Streptococcus pneumoniae R6 934082 NP_359018.1 CDS aldR NC_003098.1 1410440 1410820 R endoribonuclease L-PSP complement(1410440..1410820) Streptococcus pneumoniae R6 933389 NP_359019.1 CDS engB NC_003098.1 1410831 1411424 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(1410831..1411424) Streptococcus pneumoniae R6 933284 NP_359020.1 CDS clpX NC_003098.1 1411427 1412659 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1411427..1412659) Streptococcus pneumoniae R6 933131 NP_359021.1 CDS spr1428 NC_003098.1 1412691 1412861 R hypothetical protein complement(1412691..1412861) Streptococcus pneumoniae R6 933094 NP_359022.1 CDS dfr NC_003098.1 1412861 1413367 R dihydrofolate reductase complement(1412861..1413367) Streptococcus pneumoniae R6 933011 NP_359023.1 CDS dpr NC_003098.1 1413497 1414033 R non-heme iron-containing ferritin complement(1413497..1414033) Streptococcus pneumoniae R6 933945 NP_359024.1 CDS lytC NC_003098.1 1414511 1416016 R 1,4-beta-N-acetylmuramidase complement(1414511..1416016) Streptococcus pneumoniae R6 933163 NP_359025.1 CDS tpiA NC_003098.1 1416054 1416833 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(1416054..1416833) Streptococcus pneumoniae R6 933104 NP_359026.1 CDS spr1433 NC_003098.1 1416910 1417587 R hypothetical protein complement(1416910..1417587) Streptococcus pneumoniae R6 933431 NP_359027.1 CDS metA NC_003098.1 1417596 1418540 R catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase complement(1417596..1418540) Streptococcus pneumoniae R6 933387 NP_359028.1 CDS apt NC_003098.1 1418722 1419252 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(1418722..1419252) Streptococcus pneumoniae R6 933430 NP_359029.1 CDS spr1436 NC_003098.1 1419322 1420080 R Methyltransferase-like protein; hypothetical protein complement(1419322..1420080) Streptococcus pneumoniae R6 933409 NP_359030.1 CDS msmK NC_003098.1 1420581 1421711 R sugar ABC transporter ATP-binding protein complement(1420581..1421711) Streptococcus pneumoniae R6 933410 NP_359031.1 CDS entB NC_003098.1 1422161 1422736 R isochorismatase complement(1422161..1422736) Streptococcus pneumoniae R6 933750 NP_359032.1 CDS codY NC_003098.1 1422736 1423524 R CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY complement(1422736..1423524) Streptococcus pneumoniae R6 933916 NP_359033.1 CDS spr1440 NC_003098.1 1423788 1425362 R Probable ATP-dependent RNA helicase; ATP-dependent RNA helicase complement(1423788..1425362) Streptococcus pneumoniae R6 933241 NP_359034.1 CDS oxlT NC_003098.1 1425561 1426787 R oxalate:formate antiporter complement(1425561..1426787) Streptococcus pneumoniae R6 933237 NP_359035.1 CDS merA NC_003098.1 1426977 1428293 D Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 1426977..1428293 Streptococcus pneumoniae R6 933259 NP_359036.1 CDS spr1443 NC_003098.1 1428392 1429735 D three-substrate amide ligase belonging tothe mur-ligase; hypothetical protein 1428392..1429735 Streptococcus pneumoniae R6 933333 NP_359037.1 CDS cobQ NC_003098.1 1429735 1430517 D hypothetical protein 1429735..1430517 Streptococcus pneumoniae R6 933453 NP_359038.1 CDS pepQ NC_003098.1 1430643 1431725 D dipeptidase 1430643..1431725 Streptococcus pneumoniae R6 933393 NP_359039.1 CDS spr1446 NC_003098.1 1432048 1432536 R integrase complement(1432048..1432536) Streptococcus pneumoniae R6 933278 NP_359040.1 CDS spr1447 NC_003098.1 1432598 1432870 R hypothetical protein complement(1432598..1432870) Streptococcus pneumoniae R6 933311 NP_359041.1 CDS spr1448 NC_003098.1 1433096 1433368 R hypothetical protein complement(1433096..1433368) Streptococcus pneumoniae R6 932992 NP_359042.1 CDS spr1449 NC_003098.1 1433540 1434001 R hypothetical protein complement(1433540..1434001) Streptococcus pneumoniae R6 933240 NP_359043.1 CDS pdxK NC_003098.1 1433979 1434752 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(1433979..1434752) Streptococcus pneumoniae R6 933776 NP_359044.1 CDS truA NC_003098.1 1434742 1435491 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(1434742..1435491) Streptococcus pneumoniae R6 933799 NP_359046.1 CDS MFS_transporter NC_003098.1 1435804 1436955 R major facilitator transporter complement(1435804..1436955) Streptococcus pneumoniae R6 933474 NP_359047.1 CDS spr1454 NC_003098.1 1437195 1437824 R hypothetical protein complement(1437195..1437824) Streptococcus pneumoniae R6 934038 NP_359048.1 CDS phnA NC_003098.1 1437827 1438165 R hypothetical protein complement(1437827..1438165) Streptococcus pneumoniae R6 933081 NP_359049.1 CDS cmk NC_003098.1 1438296 1438967 R Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase complement(1438296..1438967) Streptococcus pneumoniae R6 933855 NP_359050.1 CDS spr1457 NC_003098.1 1438976 1439452 R hypothetical protein complement(1438976..1439452) Streptococcus pneumoniae R6 933097 NP_359051.1 CDS fer NC_003098.1 1439432 1439710 D ferredoxin 1439432..1439710 Streptococcus pneumoniae R6 933123 NP_359052.1 CDS gtrB NC_003098.1 1439772 1440863 R glycosil transferase complement(1439772..1440863) Streptococcus pneumoniae R6 933830 NP_359053.1 CDS galE NC_003098.1 1440727 1441746 R UDP-glucose 4-epimerase complement(1440727..1441746) Streptococcus pneumoniae R6 933804 NP_359054.1 CDS spr1461 NC_003098.1 1442047 1443159 R Probable oxidase; hypothetical protein complement(1442047..1443159) Streptococcus pneumoniae R6 934040 NP_359055.1 CDS spr1462 NC_003098.1 1443167 1443964 R hypothetical protein complement(1443167..1443964) Streptococcus pneumoniae R6 933251 NP_359056.1 CDS spr1463 NC_003098.1 1443951 1444628 R hypothetical protein complement(1443951..1444628) Streptococcus pneumoniae R6 933452 NP_359057.1 CDS ctpE NC_003098.1 1444730 1447066 R metal cation transporter P-type ATPase complement(1444730..1447066) Streptococcus pneumoniae R6 934036 NP_359058.1 CDS spr1465 NC_003098.1 1447154 1447948 D Probable member of acyltransferase; hypothetical protein 1447154..1447948 Streptococcus pneumoniae R6 933161 NP_359059.1 CDS cadD NC_003098.1 1448241 1448855 R cadmium resistance protein complement(1448241..1448855) Streptococcus pneumoniae R6 933449 NP_359060.1 CDS rpsO NC_003098.1 1449589 1449858 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(1449589..1449858) Streptococcus pneumoniae R6 934037 NP_359061.1 CDS spr1468 NC_003098.1 1449999 1450628 R hypothetical protein complement(1449999..1450628) Streptococcus pneumoniae R6 932978 NP_359065.2 CDS thrS NC_003098.1 1451879 1453822 D catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1451879..1453822 Streptococcus pneumoniae R6 934039 NP_359066.1 CDS hk01 NC_003098.1 1453871 1454845 R sensor histidine kinase complement(1453871..1454845) Streptococcus pneumoniae R6 933107 NP_359067.1 CDS rr01 NC_003098.1 1454838 1455515 R DNA-binding response regulator complement(1454838..1455515) Streptococcus pneumoniae R6 933349 NP_359068.1 CDS spr1475 NC_003098.1 1455671 1456744 D hypothetical protein 1455671..1456744 Streptococcus pneumoniae R6 933114 NP_359069.1 CDS spr1476 NC_003098.1 1456835 1457137 R hypothetical protein complement(1456835..1457137) Streptococcus pneumoniae R6 933100 NP_359070.1 CDS spr1477 NC_003098.1 1457206 1457643 R Rrf2 family protein complement(1457206..1457643) Streptococcus pneumoniae R6 934035 NP_359072.1 CDS spr1479 NC_003098.1 1457719 1458567 R hypothetical protein complement(1457719..1458567) Streptococcus pneumoniae R6 933056 NP_359073.1 CDS marR NC_003098.1 1458673 1459323 D iron-dependent transcriptional regulator 1458673..1459323 Streptococcus pneumoniae R6 933026 NP_359074.1 CDS spr1481 NC_003098.1 1459304 1459474 D hypothetical protein 1459304..1459474 Streptococcus pneumoniae R6 933112 NP_359076.1 CDS spr1483 NC_003098.1 1460276 1460713 D hypothetical protein 1460276..1460713 Streptococcus pneumoniae R6 933051 NP_359077.1 CDS spr1484 NC_003098.1 1460808 1461107 R hypothetical protein complement(1460808..1461107) Streptococcus pneumoniae R6 933074 NP_359079.1 CDS spr1486 NC_003098.1 1462462 1462905 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(1462462..1462905) Streptococcus pneumoniae R6 933118 NP_359080.1 CDS relA NC_003098.1 1462935 1465157 R GTP pyrophosphokinase complement(1462935..1465157) Streptococcus pneumoniae R6 933127 NP_359083.1 CDS spr1490 NC_003098.1 1466101 1466781 D Probable member of metallo-beta-lactamase superfamily; metallo-beta-lactamase superfamily protein 1466101..1466781 Streptococcus pneumoniae R6 933105 NP_359084.1 CDS pepO NC_003098.1 1466904 1468796 R endopeptidase O complement(1466904..1468796) Streptococcus pneumoniae R6 933477 NP_359085.1 CDS psaB NC_003098.1 1469087 1469809 D manganese ABC transporter ATP-binding protein 1469087..1469809 Streptococcus pneumoniae R6 933772 NP_359086.1 CDS psaC NC_003098.1 1469806 1470654 D manganese ABC transporter permease 1469806..1470654 Streptococcus pneumoniae R6 933751 NP_359087.1 CDS psaA NC_003098.1 1470686 1471615 D manganese ABC transporter substrate-binding protein 1470686..1471615 Streptococcus pneumoniae R6 933003 NP_359088.2 CDS tpx NC_003098.1 1471738 1472229 D antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1471738..1472229 Streptococcus pneumoniae R6 933932 NP_359089.1 CDS spr1496 NC_003098.1 1472325 1475099 R hypothetical protein complement(1472325..1475099) Streptococcus pneumoniae R6 933117 NP_359090.1 CDS ABC-NBD NC_003098.1 1475035 1475745 R ABC transporter ATP-binding protein complement(1475035..1475745) Streptococcus pneumoniae R6 933758 NP_359091.1 CDS spr1498 NC_003098.1 1475986 1478397 R large secreted protein; hypothetical protein complement(1475986..1478397) Streptococcus pneumoniae R6 933748 NP_359092.1 CDS gpmA NC_003098.1 1478450 1479142 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(1478450..1479142) Streptococcus pneumoniae R6 933138 NP_359093.1 CDS spr1500 NC_003098.1 1479193 1479381 R hypothetical protein complement(1479193..1479381) Streptococcus pneumoniae R6 933817 NP_359095.1 CDS ileS NC_003098.1 1480465 1483257 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase complement(1480465..1483257) Streptococcus pneumoniae R6 933475 NP_359096.1 CDS spr1503 NC_003098.1 1483401 1483562 R hypothetical protein complement(1483401..1483562) Streptococcus pneumoniae R6 933024 NP_359098.1 CDS divIVA NC_003098.1 1483605 1484405 R cell division protein DivIVA complement(1483605..1484405) Streptococcus pneumoniae R6 933446 NP_359099.1 CDS spr1506 NC_003098.1 1484402 1485253 R hypothetical protein complement(1484402..1485253) Streptococcus pneumoniae R6 933236 NP_359100.1 CDS spr1507 NC_003098.1 1485184 1485447 R hypothetical protein complement(1485184..1485447) Streptococcus pneumoniae R6 934045 NP_359101.1 CDS spr1508 NC_003098.1 1485447 1485986 R hypothetical protein complement(1485447..1485986) Streptococcus pneumoniae R6 933746 NP_359102.1 CDS spr1509 NC_003098.1 1485996 1486667 R hypothetical protein complement(1485996..1486667) Streptococcus pneumoniae R6 933484 NP_359103.1 CDS ftsZ NC_003098.1 1486672 1487931 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(1486672..1487931) Streptococcus pneumoniae R6 933826 NP_359104.1 CDS ftsA NC_003098.1 1487948 1489321 R cell division protein FtsA complement(1487948..1489321) Streptococcus pneumoniae R6 933392 NP_359105.1 CDS spr1512 NC_003098.1 1489540 1490244 R hypothetical protein complement(1489540..1490244) Streptococcus pneumoniae R6 933008 NP_359106.1 CDS mutT NC_003098.1 1490335 1490946 R MutT/nudix family protein complement(1490335..1490946) Streptococcus pneumoniae R6 933010 NP_359107.1 CDS murF NC_003098.1 1490933 1492306 R UDP-N-acetylmuramoylalanine-D-glutamyl-lysine-D- alanyl-D-alanine ligase complement(1490933..1492306) Streptococcus pneumoniae R6 933049 NP_359108.1 CDS ddl NC_003098.1 1492390 1493433 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(1492390..1493433) Streptococcus pneumoniae R6 933362 NP_359109.1 CDS recR NC_003098.1 1493609 1494205 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(1493609..1494205) Streptococcus pneumoniae R6 933153 NP_359110.1 CDS pbp2b NC_003098.1 1494216 1496273 R penicillin-binding protein 2B complement(1494216..1496273) Streptococcus pneumoniae R6 933948 NP_359111.1 CDS spr1518 NC_003098.1 1496473 1497324 D Probable transcriptional regulator; phosphosugar-binding transcriptional regulator 1496473..1497324 Streptococcus pneumoniae R6 933935 NP_359112.1 CDS glk NC_003098.1 1497340 1498224 R ROK family protein complement(1497340..1498224) Streptococcus pneumoniae R6 933382 NP_359115.1 CDS spr1522 NC_003098.1 1499342 1499806 R hypothetical protein complement(1499342..1499806) Streptococcus pneumoniae R6 933394 NP_359116.1 CDS spr1523 NC_003098.1 1500093 1500437 R hypothetical protein complement(1500093..1500437) Streptococcus pneumoniae R6 933062 NP_359117.1 CDS spr1524 NC_003098.1 1500534 1500986 R hypothetical protein complement(1500534..1500986) Streptococcus pneumoniae R6 933054 NP_359118.1 CDS ABC-MSP NC_003098.1 1501259 1502098 R sugar ABC transporter permease complement(1501259..1502098) Streptococcus pneumoniae R6 933433 NP_359119.1 CDS ABC-MSP NC_003098.1 1502114 1503010 R sugar ABC transporter permease complement(1502114..1503010) Streptococcus pneumoniae R6 933757 NP_359120.1 CDS ABC-SBP NC_003098.1 1503232 1504560 R sugar ABC transporter substrate-binding protein complement(1503232..1504560) Streptococcus pneumoniae R6 933832 NP_359121.1 CDS PTS-EII NC_003098.1 1504685 1506217 R PTS system transporter subunit IIBC complement(1504685..1506217) Streptococcus pneumoniae R6 933910 NP_359122.1 CDS nanE NC_003098.1 1506221 1506919 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(1506221..1506919) Streptococcus pneumoniae R6 933779 NP_359123.1 CDS spr1530 NC_003098.1 1507099 1508202 R Probable Oxidoreductase, GFO/IDH/MOCA family; hypothetical protein complement(1507099..1508202) Streptococcus pneumoniae R6 933464 NP_359124.1 CDS nanB NC_003098.1 1508214 1510307 R neuraminidase B complement(1508214..1510307) Streptococcus pneumoniae R6 933504 NP_359125.1 CDS ABC-MSP NC_003098.1 1510325 1511158 R ABC transporter permease complement(1510325..1511158) Streptococcus pneumoniae R6 933445 NP_359126.1 CDS ABC-MSP NC_003098.1 1511158 1512042 R ABC transporter permease complement(1511158..1512042) Streptococcus pneumoniae R6 932934 NP_359127.1 CDS ABC-SBP NC_003098.1 1512121 1513458 R ABC transporter substrate-binding protein complement(1512121..1513458) Streptococcus pneumoniae R6 933015 NP_359128.1 CDS spr1535 NC_003098.1 1513477 1513929 R hypothetical protein complement(1513477..1513929) Streptococcus pneumoniae R6 933295 NP_359129.1 CDS nanA NC_003098.1 1514944 1518051 R neuraminidase A complement(1514944..1518051) Streptococcus pneumoniae R6 933902 NP_359130.1 CDS spr1537 NC_003098.1 1518294 1518521 R hypothetical protein complement(1518294..1518521) Streptococcus pneumoniae R6 933895 NP_359131.1 CDS axe1 NC_003098.1 1519416 1520396 R acetyl xylan esterase complement(1519416..1520396) Streptococcus pneumoniae R6 933372 NP_359132.1 CDS recG NC_003098.1 1520712 1522727 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(1520712..1522727) Streptococcus pneumoniae R6 933472 NP_359133.1 CDS alr NC_003098.1 1522746 1523870 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(1522746..1523870) Streptococcus pneumoniae R6 933368 NP_359134.1 CDS acpS NC_003098.1 1523839 1524201 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(1523839..1524201) Streptococcus pneumoniae R6 933057 NP_359135.1 CDS aroF NC_003098.1 1524246 1525277 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1524246..1525277) Streptococcus pneumoniae R6 932815 NP_359136.1 CDS aroG NC_003098.1 1525279 1526310 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1525279..1526310) Streptococcus pneumoniae R6 933155 NP_359137.1 CDS secA NC_003098.1 1526391 1528904 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(1526391..1528904) Streptococcus pneumoniae R6 933782 NP_359138.1 CDS spr1545 NC_003098.1 1529050 1529250 R hypothetical protein complement(1529050..1529250) Streptococcus pneumoniae R6 933079 NP_359139.1 CDS ABC-NBD NC_003098.1 1529350 1530000 R ABC transporter ATP-binding protein complement(1529350..1530000) Streptococcus pneumoniae R6 933956 NP_359140.1 CDS spr1547 NC_003098.1 1530004 1530681 R hypothetical protein complement(1530004..1530681) Streptococcus pneumoniae R6 933752 NP_359141.1 CDS spr1548 NC_003098.1 1530638 1531429 R hypothetical protein complement(1530638..1531429) Streptococcus pneumoniae R6 933749 NP_359142.1 CDS spr1549 NC_003098.1 1531451 1531843 R hypothetical protein complement(1531451..1531843) Streptococcus pneumoniae R6 933033 NP_359143.1 CDS spr1550 NC_003098.1 1532170 1533021 D Similar to MutR protein; hypothetical protein 1532170..1533021 Streptococcus pneumoniae R6 933229 NP_359144.1 CDS spr1551 NC_003098.1 1533243 1533596 R hypothetical protein complement(1533243..1533596) Streptococcus pneumoniae R6 933020 NP_359145.1 CDS spr1552 NC_003098.1 1533733 1534077 R hypothetical protein complement(1533733..1534077) Streptococcus pneumoniae R6 932941 NP_359146.1 CDS engA NC_003098.1 1534157 1535467 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(1534157..1535467) Streptococcus pneumoniae R6 933135 NP_359147.1 CDS frp NC_003098.1 1535481 1536194 R nitroreductase complement(1535481..1536194) Streptococcus pneumoniae R6 933420 NP_359148.1 CDS dnaI NC_003098.1 1536191 1537087 R Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI complement(1536191..1537087) Streptococcus pneumoniae R6 933865 NP_359149.1 CDS dnaB NC_003098.1 1537088 1538257 R hypothetical protein complement(1537088..1538257) Streptococcus pneumoniae R6 933424 NP_359150.2 CDS nrdR NC_003098.1 1538258 1538731 R transcriptional regulator NrdR complement(1538258..1538731) Streptococcus pneumoniae R6 933896 NP_359151.1 CDS spr1558 NC_003098.1 1538871 1539236 D Similar to transcriptional regulator (GntR family); hypothetical protein 1538871..1539236 Streptococcus pneumoniae R6 933463 NP_359152.1 CDS ABC-NBD NC_003098.1 1539214 1539936 D ABC transporter ATP-binding protein 1539214..1539936 Streptococcus pneumoniae R6 933133 NP_359153.1 CDS spr1560 NC_003098.1 1539872 1540720 D hypothetical protein 1539872..1540720 Streptococcus pneumoniae R6 933149 NP_359154.1 CDS natB NC_003098.1 1541133 1542332 R hypothetical protein complement(1541133..1542332) Streptococcus pneumoniae R6 933936 NP_359155.1 CDS natA NC_003098.1 1542329 1543222 R ABC transporter ATP-binding protein complement(1542329..1543222) Streptococcus pneumoniae R6 933125 NP_359157.1 CDS spr1564 NC_003098.1 1544531 1545148 D hypothetical protein 1544531..1545148 Streptococcus pneumoniae R6 933073 NP_359158.1 CDS scrK NC_003098.1 1545468 1546355 R fructokinase complement(1545468..1546355) Streptococcus pneumoniae R6 933152 NP_359159.1 CDS scrA NC_003098.1 1546504 1548387 R PTS system transporter subunit IIABC complement(1546504..1548387) Streptococcus pneumoniae R6 933361 NP_359160.1 CDS scrB NC_003098.1 1548764 1550218 D sucrose-6-phosphate hydrolase 1548764..1550218 Streptococcus pneumoniae R6 933454 NP_359161.1 CDS scrR NC_003098.1 1550199 1551164 D sucrose operon repressor 1550199..1551164 Streptococcus pneumoniae R6 933292 NP_359162.1 CDS mvaA NC_003098.1 1551199 1552473 R 3-hydroxy-3-methylglutaryl-CoA reductase complement(1551199..1552473) Streptococcus pneumoniae R6 932918 NP_359163.1 CDS mvaS NC_003098.1 1552473 1553669 R hydroxymethylglutaryl-CoA synthase complement(1552473..1553669) Streptococcus pneumoniae R6 933931 NP_359164.1 CDS spr1572 NC_003098.1 1553776 1554063 R hypothetical protein complement(1553776..1554063) Streptococcus pneumoniae R6 933874 NP_359165.1 CDS IS1381 NC_003098.1 1554092 1554481 R tranposase complement(1554092..1554481) Streptococcus pneumoniae R6 933925 NP_359167.1 CDS spr1575 NC_003098.1 1554780 1555229 R hypothetical protein complement(1554780..1555229) Streptococcus pneumoniae R6 933128 NP_359168.1 CDS spr1576 NC_003098.1 1555231 1555989 R hypothetical protein complement(1555231..1555989) Streptococcus pneumoniae R6 933309 NP_359169.1 CDS pkn2 NC_003098.1 1556104 1558083 R serine/threonine protein kinase complement(1556104..1558083) Streptococcus pneumoniae R6 933070 NP_359170.1 CDS pppL NC_003098.1 1558080 1558820 R phosphatase complement(1558080..1558820) Streptococcus pneumoniae R6 933328 NP_359171.1 CDS sunL NC_003098.1 1558835 1560151 R rRNA methylase complement(1558835..1560151) Streptococcus pneumoniae R6 933344 NP_359172.1 CDS fmt NC_003098.1 1560141 1561076 R modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase complement(1560141..1561076) Streptococcus pneumoniae R6 933459 NP_359173.1 CDS priA NC_003098.1 1561089 1563485 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(1561089..1563485) Streptococcus pneumoniae R6 933323 NP_359174.1 CDS spr1582 NC_003098.1 1563551 1563865 R Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(1563551..1563865) Streptococcus pneumoniae R6 933835 NP_359175.1 CDS gmk NC_003098.1 1563890 1564516 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(1563890..1564516) Streptococcus pneumoniae R6 933273 NP_359176.1 CDS spr1584 NC_003098.1 1564646 1566259 R hypothetical protein complement(1564646..1566259) Streptococcus pneumoniae R6 933269 NP_359177.1 CDS spr1585 NC_003098.1 1566450 1566704 R hypothetical protein complement(1566450..1566704) Streptococcus pneumoniae R6 933264 NP_359178.1 CDS spr1586 NC_003098.1 1566708 1567001 R hypothetical protein complement(1566708..1567001) Streptococcus pneumoniae R6 933314 NP_359179.1 CDS spr1587 NC_003098.1 1567200 1568297 R hypothetical protein complement(1567200..1568297) Streptococcus pneumoniae R6 933243 NP_359180.1 CDS spr1588 NC_003098.1 1568307 1569053 R hypothetical protein complement(1568307..1569053) Streptococcus pneumoniae R6 933287 NP_359181.1 CDS spr1589 NC_003098.1 1569156 1569509 R iojap-related protein complement(1569156..1569509) Streptococcus pneumoniae R6 933139 NP_359182.1 CDS spr1590 NC_003098.1 1569522 1570022 R Similar to isochorismatase; isochorismatase complement(1569522..1570022) Streptococcus pneumoniae R6 933302 NP_359183.1 CDS spr1591 NC_003098.1 1570023 1570616 R hypothetical protein complement(1570023..1570616) Streptococcus pneumoniae R6 933060 NP_359184.1 CDS nadD NC_003098.1 1570616 1571245 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(1570616..1571245) Streptococcus pneumoniae R6 933444 NP_359185.1 CDS spr1593 NC_003098.1 1571297 1571608 R hypothetical protein complement(1571297..1571608) Streptococcus pneumoniae R6 933137 NP_359186.1 CDS spr1594 NC_003098.1 1571823 1572929 R in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH complement(1571823..1572929) Streptococcus pneumoniae R6 933397 NP_359187.1 CDS spr1595 NC_003098.1 1572932 1573522 R hypothetical protein complement(1572932..1573522) Streptococcus pneumoniae R6 933109 NP_359188.1 CDS corA NC_003098.1 1573474 1574370 R magnesium and cobalt transporter CorA complement(1573474..1574370) Streptococcus pneumoniae R6 933228 NP_359189.1 CDS spr1597 NC_003098.1 1574427 1575032 R hypothetical protein complement(1574427..1575032) Streptococcus pneumoniae R6 933438 NP_359190.1 CDS dctA NC_003098.1 1575376 1576335 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 1575376..1576335 Streptococcus pneumoniae R6 933071 NP_359191.1 CDS spr1599 NC_003098.1 1576403 1577356 D hypothetical protein 1576403..1577356 Streptococcus pneumoniae R6 933402 NP_359192.1 CDS spr1600 NC_003098.1 1577455 1577880 D Probable transcription regulator; transcriptional regulator 1577455..1577880 Streptococcus pneumoniae R6 933307 NP_359193.1 CDS spr1601 NC_003098.1 1577898 1578200 D hypothetical protein 1577898..1578200 Streptococcus pneumoniae R6 933432 NP_359194.1 CDS trxA NC_003098.1 1578217 1578531 D thioredoxin 1578217..1578531 Streptococcus pneumoniae R6 933436 NP_359195.1 CDS spr1603 NC_003098.1 1578797 1579369 D NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 1578797..1579369 Streptococcus pneumoniae R6 933864 YP_008719805.1 CDS spr1603a NC_003098.1 1579381 1579824 D hypothetical protein 1579381..1579824 Streptococcus pneumoniae R6 17374510 NP_359196.1 CDS aqpZ NC_003098.1 1579849 1580517 R aquaporin complement(1579849..1580517) Streptococcus pneumoniae R6 933893 NP_359197.1 CDS spr1605 NC_003098.1 1580628 1581188 R hypothetical protein complement(1580628..1581188) Streptococcus pneumoniae R6 934041 NP_359198.1 CDS pepF NC_003098.1 1581428 1583224 R oligoendopeptidase F complement(1581428..1583224) Streptococcus pneumoniae R6 933318 NP_359199.1 CDS spr1607 NC_003098.1 1583235 1583990 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(1583235..1583990) Streptococcus pneumoniae R6 933160 NP_359200.2 CDS prmA NC_003098.1 1583980 1584930 R methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase complement(1583980..1584930) Streptococcus pneumoniae R6 934029 NP_359201.1 CDS mutT NC_003098.1 1585068 1585496 R MutT/nudix family protein complement(1585068..1585496) Streptococcus pneumoniae R6 933359 NP_359202.1 CDS spr1610 NC_003098.1 1585462 1586580 R hypothetical protein complement(1585462..1586580) Streptococcus pneumoniae R6 933498 NP_359203.1 CDS spr1611 NC_003098.1 1586584 1587054 R hypothetical protein complement(1586584..1587054) Streptococcus pneumoniae R6 933786 NP_359204.1 CDS spr1612 NC_003098.1 1587345 1587797 R hypothetical protein complement(1587345..1587797) Streptococcus pneumoniae R6 933845 NP_359205.1 CDS spr1613 NC_003098.1 1587834 1588040 R hypothetical protein complement(1587834..1588040) Streptococcus pneumoniae R6 933465 NP_359206.1 CDS spr1614 NC_003098.1 1588150 1588329 R hypothetical protein complement(1588150..1588329) Streptococcus pneumoniae R6 933308 NP_359207.1 CDS spr1615 NC_003098.1 1588494 1588733 R hypothetical protein complement(1588494..1588733) Streptococcus pneumoniae R6 933744 NP_359208.1 CDS cshA NC_003098.1 1589003 1590274 D recombination factor protein RarA 1589003..1590274 Streptococcus pneumoniae R6 933195 NP_359209.1 CDS sacA NC_003098.1 1590821 1592140 R sucrose-6-phosphate hydrolase complement(1590821..1592140) Streptococcus pneumoniae R6 933211 NP_359210.1 CDS ABC-MSP NC_003098.1 1592150 1593004 R sugar ABC transporter permease complement(1592150..1593004) Streptococcus pneumoniae R6 933483 NP_359211.1 CDS ABC-MSP NC_003098.1 1592997 1593905 R sugar ABC transporter permease complement(1592997..1593905) Streptococcus pneumoniae R6 932933 NP_359212.1 CDS ABC-SBP NC_003098.1 1593995 1595308 R sugar ABC transporter substrate-binding protein complement(1593995..1595308) Streptococcus pneumoniae R6 933745 NP_359213.1 CDS scrR NC_003098.1 1595432 1596445 R sucrose operon repressor complement(1595432..1596445) Streptococcus pneumoniae R6 933960 NP_359214.1 CDS spr1622 NC_003098.1 1596789 1598327 R regulator protein; hypothetical protein complement(1596789..1598327) Streptococcus pneumoniae R6 933678 NP_359215.1 CDS spr1623 NC_003098.1 1598954 1599526 D hypothetical protein 1598954..1599526 Streptococcus pneumoniae R6 932829 NP_359216.1 CDS spr1624 NC_003098.1 1599538 1599708 D hypothetical protein 1599538..1599708 Streptococcus pneumoniae R6 933828 NP_359217.1 CDS spr1625 NC_003098.1 1599747 1600355 D general stress protein 24 1599747..1600355 Streptococcus pneumoniae R6 933793 NP_359218.1 CDS spr1626 NC_003098.1 1600386 1600589 D hypothetical protein 1600386..1600589 Streptococcus pneumoniae R6 933216 NP_359219.1 CDS spr1627 NC_003098.1 1601116 1601562 R Probable acetyltransferase; hypothetical protein complement(1601116..1601562) Streptococcus pneumoniae R6 933262 NP_359220.1 CDS pilD NC_003098.1 1601632 1602291 D type IV prepilin peptidase 1601632..1602291 Streptococcus pneumoniae R6 933620 NP_359221.1 CDS spr1629 NC_003098.1 1602343 1603494 R DNA-binding protein; transcriptional regulator complement(1602343..1603494) Streptococcus pneumoniae R6 933063 NP_359222.1 CDS spr1630 NC_003098.1 1603509 1604240 R hypothetical protein complement(1603509..1604240) Streptococcus pneumoniae R6 933473 NP_359223.1 CDS trpA NC_003098.1 1604542 1605318 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1604542..1605318) Streptococcus pneumoniae R6 933255 NP_359224.1 CDS trpB NC_003098.1 1605311 1606534 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1605311..1606534) Streptococcus pneumoniae R6 933618 NP_359225.1 CDS trpF NC_003098.1 1606512 1607141 R catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase complement(1606512..1607141) Streptococcus pneumoniae R6 933859 NP_359226.1 CDS trpC NC_003098.1 1607098 1607865 R involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol phosphate synthase complement(1607098..1607865) Streptococcus pneumoniae R6 933756 NP_359227.1 CDS trpD NC_003098.1 1607862 1608866 R Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase complement(1607862..1608866) Streptococcus pneumoniae R6 933836 NP_359228.1 CDS trpG NC_003098.1 1608877 1609443 R TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II complement(1608877..1609443) Streptococcus pneumoniae R6 933813 NP_359229.2 CDS trpE NC_003098.1 1609440 1610801 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1609440..1610801) Streptococcus pneumoniae R6 933781 NP_359231.1 CDS ccpA NC_003098.1 1611988 1612989 R catabolite control protein complement(1611988..1612989) Streptococcus pneumoniae R6 933352 NP_359232.1 CDS spr1640 NC_003098.1 1613097 1613465 R hypothetical protein complement(1613097..1613465) Streptococcus pneumoniae R6 933345 NP_359233.1 CDS mgtC NC_003098.1 1613561 1614271 R Mg2+ transporter complement(1613561..1614271) Streptococcus pneumoniae R6 933023 NP_359235.1 CDS ABC-MSP NC_003098.1 1614274 1615965 R ABC transporter permease complement(1614274..1615965) Streptococcus pneumoniae R6 933624 NP_359236.1 CDS ABC-NBD NC_003098.1 1615977 1616987 R ABC transporter ATP-binding protein complement(1615977..1616987) Streptococcus pneumoniae R6 933848 NP_359237.1 CDS ABC-SBP NC_003098.1 1617090 1618157 R ABC transporter substrate-binding protein complement(1617090..1618157) Streptococcus pneumoniae R6 933166 NP_359238.1 CDS spr1646 NC_003098.1 1618182 1618841 R hypothetical protein complement(1618182..1618841) Streptococcus pneumoniae R6 933543 NP_359239.1 CDS galE NC_003098.1 1619051 1620031 R UDP-glucose 4-epimerase complement(1619051..1620031) Streptococcus pneumoniae R6 933268 NP_359240.1 CDS galT NC_003098.1 1620044 1621519 R catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase complement(1620044..1621519) Streptococcus pneumoniae R6 932967 NP_359241.1 CDS spr1649 NC_003098.1 1621532 1622173 R transcriptional regulator (phoU like); phosphate transporter PhoU complement(1621532..1622173) Streptococcus pneumoniae R6 933690 NP_359244.1 CDS spr1652 NC_003098.1 1623066 1625225 R cell wall surface anchor family protein complement(1623066..1625225) Streptococcus pneumoniae R6 933108 NP_359246.1 CDS spr1654 NC_003098.1 1626356 1627609 R role in biosynthesis of amino sugar; capsular polysaccharide biosynthesis protein complement(1626356..1627609) Streptococcus pneumoniae R6 933440 NP_359247.1 CDS spr1655 NC_003098.1 1627625 1628356 R glycosyltransferase; glycosyl transferase complement(1627625..1628356) Streptococcus pneumoniae R6 932855 NP_359248.1 CDS ABC-N/P NC_003098.1 1628490 1630241 R ABC transporter ATP-binding protein/permease complement(1628490..1630241) Streptococcus pneumoniae R6 934027 NP_359249.1 CDS ABC-N/P NC_003098.1 1630231 1632015 R ABC transporter ATP-binding protein/permease complement(1630231..1632015) Streptococcus pneumoniae R6 934046 NP_359252.1 CDS exoA NC_003098.1 1633221 1634048 D exodeoxyribonuclease 1633221..1634048 Streptococcus pneumoniae R6 933227 NP_359253.1 CDS spr1661 NC_003098.1 1634203 1634442 D hypothetical protein 1634203..1634442 Streptococcus pneumoniae R6 933082 NP_359254.1 CDS xpt NC_003098.1 1635320 1635901 D Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 1635320..1635901 Streptococcus pneumoniae R6 934026 NP_359255.1 CDS pbuX NC_003098.1 1635901 1637163 D xanthine permease 1635901..1637163 Streptococcus pneumoniae R6 933092 NP_359256.1 CDS dpnD NC_003098.1 1637214 1637675 R hypothetical protein complement(1637214..1637675) Streptococcus pneumoniae R6 933798 NP_359257.1 CDS dpnC NC_003098.1 1637672 1638436 R type II restriction enzyme DpnI (dpnC) complement(1637672..1638436) Streptococcus pneumoniae R6 933882 NP_359258.1 CDS spr1666 NC_003098.1 1638617 1639042 R Similar to E. coli PaaI protein involved in phenylacetic acid degradation; hypothetical protein complement(1638617..1639042) Streptococcus pneumoniae R6 933648 NP_359259.1 CDS galT NC_003098.1 1639091 1640572 R catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase complement(1639091..1640572) Streptococcus pneumoniae R6 933029 NP_359260.1 CDS galK NC_003098.1 1640591 1641769 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(1640591..1641769) Streptococcus pneumoniae R6 933086 NP_359261.1 CDS galR NC_003098.1 1641933 1642940 D regulator of gal operon GalR 1641933..1642940 Streptococcus pneumoniae R6 934048 NP_359262.1 CDS adhB NC_003098.1 1642986 1644023 R zinc-containing alcohol dehydrogenase complement(1642986..1644023) Streptococcus pneumoniae R6 933078 NP_359263.1 CDS spr1671 NC_003098.1 1644024 1644377 R Similar to transcriptional regulator (MerR family); hypothetical protein complement(1644024..1644377) Streptococcus pneumoniae R6 932950 NP_359264.1 CDS czcD NC_003098.1 1644621 1645520 R cation efflux system protein complement(1644621..1645520) Streptococcus pneumoniae R6 933821 NP_359265.1 CDS spr1673 NC_003098.1 1645644 1646180 D tetR-family transcriptional regulator; hypothetical protein 1645644..1646180 Streptococcus pneumoniae R6 933091 NP_359266.1 CDS spr1674 NC_003098.1 1646347 1647156 R hypothetical protein complement(1646347..1647156) Streptococcus pneumoniae R6 933875 NP_359267.1 CDS IS1167 NC_003098.1 1647556 1648074 D transposase 1647556..1648074 Streptococcus pneumoniae R6 933126 NP_359269.1 CDS proWX NC_003098.1 1648982 1650502 R choline ABC transporter permease complement(1648982..1650502) Streptococcus pneumoniae R6 933005 NP_359270.1 CDS proV NC_003098.1 1650495 1651223 R choline transporter complement(1650495..1651223) Streptococcus pneumoniae R6 933246 NP_359271.1 CDS spr1679 NC_003098.1 1651238 1652002 R hypothetical protein complement(1651238..1652002) Streptococcus pneumoniae R6 933998 NP_359272.1 CDS spr1680 NC_003098.1 1652006 1652449 R transcriptional regulator; hypothetical protein complement(1652006..1652449) Streptococcus pneumoniae R6 934024 NP_359273.1 CDS spr1681 NC_003098.1 1653131 1653436 R hypothetical protein complement(1653131..1653436) Streptococcus pneumoniae R6 932956 NP_359274.1 CDS pepA NC_003098.1 1653449 1654513 R glutamyl aminopeptidase complement(1653449..1654513) Streptococcus pneumoniae R6 932959 NP_359275.1 CDS spr1683 NC_003098.1 1654914 1655615 D NAD-dependent epimerase/dehydratase 1654914..1655615 Streptococcus pneumoniae R6 933099 NP_359276.1 CDS fatD NC_003098.1 1656023 1656997 D iron-compound ABC transporter permease 1656023..1656997 Streptococcus pneumoniae R6 933870 NP_359277.1 CDS fatC NC_003098.1 1656987 1657943 D iron-compound ABC transporter permease 1656987..1657943 Streptococcus pneumoniae R6 932929 NP_359278.1 CDS fecE NC_003098.1 1657940 1658692 D iron-compound ABC transporter ATP-binding protein 1657940..1658692 Streptococcus pneumoniae R6 933979 NP_359279.1 CDS fatB NC_003098.1 1658788 1659753 D iron-compound ABC transporter substrate-binding protein 1658788..1659753 Streptococcus pneumoniae R6 933306 NP_359280.1 CDS spr1688 NC_003098.1 1659978 1660220 R hypothetical protein complement(1659978..1660220) Streptococcus pneumoniae R6 933934 NP_359281.1 CDS rluB NC_003098.1 1660220 1660942 R ribosomal large subunit pseudouridine synthase B complement(1660220..1660942) Streptococcus pneumoniae R6 933891 NP_359282.1 CDS scpB NC_003098.1 1660929 1661498 R functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B complement(1660929..1661498) Streptococcus pneumoniae R6 933665 NP_359283.1 CDS scpA NC_003098.1 1661517 1662245 R functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A complement(1661517..1662245) Streptococcus pneumoniae R6 933770 NP_359284.1 CDS xerD NC_003098.1 1662245 1662985 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD-like protein complement(1662245..1662985) Streptococcus pneumoniae R6 932943 NP_359285.1 CDS spr1693 NC_003098.1 1662976 1663437 R hypothetical protein complement(1662976..1663437) Streptococcus pneumoniae R6 933937 NP_359286.1 CDS spr1694 NC_003098.1 1663434 1663955 R hypothetical protein complement(1663434..1663955) Streptococcus pneumoniae R6 932835 NP_359287.2 CDS spr1695 NC_003098.1 1663931 1664902 R HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; fused deoxyribonucleotide triphosphate pyrophosphatase/hypothetical protein complement(1663931..1664902) Streptococcus pneumoniae R6 933028 NP_359288.1 CDS murI NC_003098.1 1664899 1665693 R converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase complement(1664899..1665693) Streptococcus pneumoniae R6 933741 NP_359289.1 CDS spr1697 NC_003098.1 1665900 1666202 R hypothetical protein complement(1665900..1666202) Streptococcus pneumoniae R6 933041 NP_359290.1 CDS dexS NC_003098.1 1666290 1667915 R Also highly similar to trehalose-6-phosphate hydrolase; dextran glucosidase complement(1666290..1667915) Streptococcus pneumoniae R6 933881 NP_359291.1 CDS treP NC_003098.1 1668093 1670210 R PTS system trehalose-specific transporter subunit IIBC complement(1668093..1670210) Streptococcus pneumoniae R6 933714 NP_359292.1 CDS treR NC_003098.1 1670245 1670955 D trehalose operon transcriptional repressor 1670245..1670955 Streptococcus pneumoniae R6 933116 NP_359295.1 CDS amiF NC_003098.1 1672492 1673463 R oligopeptide ABC transporter ATP-binding protein AmiF complement(1672492..1673463) Streptococcus pneumoniae R6 932969 NP_359296.1 CDS amiE NC_003098.1 1673429 1674496 R oligopeptide ABC transporter ATP-binding protein AmiE complement(1673429..1674496) Streptococcus pneumoniae R6 934004 NP_359297.1 CDS amiD NC_003098.1 1674505 1675431 R oligopeptide ABC transporter permease AmiD complement(1674505..1675431) Streptococcus pneumoniae R6 932913 NP_359298.1 CDS amiC NC_003098.1 1675431 1676927 R oligopeptide ABC transporter permease AmiC complement(1675431..1676927) Streptococcus pneumoniae R6 933016 NP_359299.1 CDS amiA NC_003098.1 1676994 1678973 R oligopeptide ABC transporter substrate-binding protein complement(1676994..1678973) Streptococcus pneumoniae R6 933861 NP_359300.1 CDS spr1708 NC_003098.1 1679660 1680853 R hypothetical protein complement(1679660..1680853) Streptococcus pneumoniae R6 932951 NP_359301.1 CDS gtfA NC_003098.1 1680991 1682433 R sucrose phosphorylase complement(1680991..1682433) Streptococcus pneumoniae R6 933971 YP_008719806.1 CDS spr1709a NC_003098.1 1682617 1682784 R hypothetical protein complement(1682617..1682784) Streptococcus pneumoniae R6 17374511 NP_359302.1 CDS msmG NC_003098.1 1682791 1683624 R sugar ABC transporter permease complement(1682791..1683624) Streptococcus pneumoniae R6 933978 NP_359303.1 CDS msmF NC_003098.1 1683638 1684528 R sugar ABC transporter permease complement(1683638..1684528) Streptococcus pneumoniae R6 933920 NP_359304.1 CDS msmE NC_003098.1 1684518 1685777 R sugar ABC transporter substrate-binding protein complement(1684518..1685777) Streptococcus pneumoniae R6 933919 NP_359305.1 CDS aga NC_003098.1 1685869 1688031 R alpha-galactosidase complement(1685869..1688031) Streptococcus pneumoniae R6 933461 NP_359306.1 CDS msmR NC_003098.1 1688139 1688999 D MSM (multiple sugar metabolism) operon regulatory protein 1688139..1688999 Streptococcus pneumoniae R6 932882 NP_359307.1 CDS birA NC_003098.1 1688996 1689931 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1688996..1689931 Streptococcus pneumoniae R6 933753 NP_359309.1 CDS spr1717 NC_003098.1 1697564 1698919 R Similar to RNA methyltransferase; hypothetical protein complement(1697564..1698919) Streptococcus pneumoniae R6 933414 NP_359310.2 CDS recX NC_003098.1 1698957 1699733 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1698957..1699733 Streptococcus pneumoniae R6 933158 NP_359311.1 CDS spr1719 NC_003098.1 1699822 1700355 D hypothetical protein 1699822..1700355 Streptococcus pneumoniae R6 933375 NP_359312.1 CDS spr1720 NC_003098.1 1700709 1700915 R hypothetical protein complement(1700709..1700915) Streptococcus pneumoniae R6 933040 NP_359313.1 CDS spr1721 NC_003098.1 1701075 1702304 D transposase 1701075..1702304 Streptococcus pneumoniae R6 933774 NP_359314.1 CDS groEL NC_003098.1 1702403 1704025 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL complement(1702403..1704025) Streptococcus pneumoniae R6 932997 NP_359315.1 CDS groES NC_003098.1 1704041 1704325 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(1704041..1704325) Streptococcus pneumoniae R6 933334 NP_359316.1 CDS ssbB NC_003098.1 1704481 1704876 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1704481..1704876) Streptococcus pneumoniae R6 933820 NP_359317.1 CDS ydfG NC_003098.1 1704954 1705715 R oxidoreductase complement(1704954..1705715) Streptococcus pneumoniae R6 933630 NP_359318.1 CDS spr1726 NC_003098.1 1705748 1706374 R hypothetical protein complement(1705748..1706374) Streptococcus pneumoniae R6 933705 NP_359319.1 CDS spr1727 NC_003098.1 1706390 1706707 R Similar to thioredoxin H1; hypothetical protein complement(1706390..1706707) Streptococcus pneumoniae R6 933577 NP_359320.1 CDS spr1728 NC_003098.1 1706704 1707003 R hypothetical protein complement(1706704..1707003) Streptococcus pneumoniae R6 932863 NP_359322.1 CDS spr1730 NC_003098.1 1707692 1708366 R hypothetical protein complement(1707692..1708366) Streptococcus pneumoniae R6 933706 NP_359323.1 CDS spr1731 NC_003098.1 1708372 1708821 R hypothetical protein complement(1708372..1708821) Streptococcus pneumoniae R6 933697 NP_359324.1 CDS spr1732 NC_003098.1 1708932 1709435 R Similar to bacteriocin transport permease; PAP2 family protein complement(1708932..1709435) Streptococcus pneumoniae R6 933704 NP_359325.1 CDS spr1733 NC_003098.1 1709432 1709794 R hypothetical protein complement(1709432..1709794) Streptococcus pneumoniae R6 933703 NP_359326.1 CDS spr1734 NC_003098.1 1709860 1710891 R ABC transporter ATP-binding protein complement(1709860..1710891) Streptococcus pneumoniae R6 933695 NP_359330.1 CDS spr1738 NC_003098.1 1712329 1713045 R hypothetical protein complement(1712329..1713045) Streptococcus pneumoniae R6 933696 NP_359331.1 CDS ply NC_003098.1 1713926 1715341 R pneumolysin complement(1713926..1715341) Streptococcus pneumoniae R6 933687 NP_359332.1 CDS spr1740 NC_003098.1 1715352 1715762 R hypothetical protein complement(1715352..1715762) Streptococcus pneumoniae R6 933693 NP_359333.1 CDS spr1741 NC_003098.1 1715755 1716363 R hypothetical protein complement(1715755..1716363) Streptococcus pneumoniae R6 933692 NP_359338.1 CDS spr1746 NC_003098.1 1718122 1718382 R hypothetical protein complement(1718122..1718382) Streptococcus pneumoniae R6 933685 NP_359339.1 CDS spr1747 NC_003098.1 1718441 1718995 R hypothetical protein complement(1718441..1718995) Streptococcus pneumoniae R6 933683 NP_359340.1 CDS spr1748 NC_003098.1 1718982 1719179 R hypothetical protein complement(1718982..1719179) Streptococcus pneumoniae R6 933682 NP_359341.1 CDS spr1749 NC_003098.1 1719183 1719977 R hypothetical protein complement(1719183..1719977) Streptococcus pneumoniae R6 933674 NP_359343.1 CDS spr1751 NC_003098.1 1720939 1721298 R hypothetical protein complement(1720939..1721298) Streptococcus pneumoniae R6 933677 NP_359344.1 CDS spr1752 NC_003098.1 1721344 1721586 R hypothetical protein complement(1721344..1721586) Streptococcus pneumoniae R6 933671 NP_359345.1 CDS spr1753 NC_003098.1 1721537 1721710 R hypothetical protein complement(1721537..1721710) Streptococcus pneumoniae R6 933676 NP_359346.1 CDS lytA NC_003098.1 1722069 1723025 R N-acetylmuramoyl-L-alanine amidase complement(1722069..1723025) Streptococcus pneumoniae R6 933669 NP_359348.1 CDS dinF NC_003098.1 1723401 1724771 R MATE efflux family protein DinF complement(1723401..1724771) Streptococcus pneumoniae R6 933672 NP_359349.1 CDS recA NC_003098.1 1725078 1726244 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(1725078..1726244) Streptococcus pneumoniae R6 933670 NP_359350.1 CDS cinA NC_003098.1 1726299 1727555 R Competence induced protein A; competence damage-inducible protein A complement(1726299..1727555) Streptococcus pneumoniae R6 933663 NP_359351.1 CDS lytR NC_003098.1 1727640 1728656 R transcriptional regulator complement(1727640..1728656) Streptococcus pneumoniae R6 933667 NP_359352.1 CDS spr1760 NC_003098.1 1728664 1729182 R hypothetical protein complement(1728664..1729182) Streptococcus pneumoniae R6 933666 NP_359353.1 CDS spr1761 NC_003098.1 1729172 1729615 R hypothetical protein complement(1729172..1729615) Streptococcus pneumoniae R6 933660 NP_359354.1 CDS spr1762 NC_003098.1 1729701 1730321 R hypothetical protein complement(1729701..1730321) Streptococcus pneumoniae R6 933664 NP_359355.1 CDS plcR NC_003098.1 1730704 1731567 R transcriptional activator complement(1730704..1731567) Streptococcus pneumoniae R6 933657 NP_359356.1 CDS spr1764 NC_003098.1 1731759 1731929 D hypothetical protein 1731759..1731929 Streptococcus pneumoniae R6 933662 NP_359357.1 CDS spr1765 NC_003098.1 1732032 1732256 D hypothetical protein 1732032..1732256 Streptococcus pneumoniae R6 933661 NP_359358.1 CDS spr1766 NC_003098.1 1732263 1732451 D hypothetical protein 1732263..1732451 Streptococcus pneumoniae R6 933653 NP_359359.1 CDS cylM NC_003098.1 1732567 1735557 D bacteriocin formation protein 1732567..1735557 Streptococcus pneumoniae R6 933659 NP_359360.1 CDS spr1768 NC_003098.1 1735907 1736611 D Related to Trp repressor binding protein; hypothetical protein 1735907..1736611 Streptococcus pneumoniae R6 933658 NP_359361.1 CDS spr1769 NC_003098.1 1736592 1737521 D hypothetical protein 1736592..1737521 Streptococcus pneumoniae R6 933650 NP_359362.1 CDS clyB NC_003098.1 1737518 1739626 D toxin secretion ABC transporter ATP-binding/permease 1737518..1739626 Streptococcus pneumoniae R6 933656 NP_359363.1 CDS nisP NC_003098.1 1739650 1741389 D subtilisin-like serine protease 1739650..1741389 Streptococcus pneumoniae R6 933654 NP_359364.1 CDS spr1772 NC_003098.1 1741440 1742207 D hypothetical protein 1741440..1742207 Streptococcus pneumoniae R6 933646 NP_359365.1 CDS ABC-NBD NC_003098.1 1742209 1742841 D ABC transporter ATP-binding protein 1742209..1742841 Streptococcus pneumoniae R6 933652 NP_359367.1 CDS ndk NC_003098.1 1743787 1744200 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(1743787..1744200) Streptococcus pneumoniae R6 933643 NP_359368.1 CDS rpoC NC_003098.1 1744311 1747988 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(1744311..1747988) Streptococcus pneumoniae R6 933649 NP_359369.1 CDS rpoB NC_003098.1 1748021 1751671 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(1748021..1751671) Streptococcus pneumoniae R6 933647 NP_359370.1 CDS hlyX NC_003098.1 1752316 1753647 R hemolysin complement(1752316..1753647) Streptococcus pneumoniae R6 933644 NP_359371.1 CDS endA NC_003098.1 1753876 1754700 R DNA-entry nuclease complement(1753876..1754700) Streptococcus pneumoniae R6 933636 NP_359372.1 CDS epuA NC_003098.1 1754739 1754945 R hypothetical protein complement(1754739..1754945) Streptococcus pneumoniae R6 933642 NP_359373.1 CDS murA NC_003098.1 1754920 1756203 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(1754920..1756203) Streptococcus pneumoniae R6 933641 YP_008719807.1 CDS spr1781a NC_003098.1 1756227 1756457 R hypothetical protein complement(1756227..1756457) Streptococcus pneumoniae R6 17374512 NP_359374.1 CDS spr1782 NC_003098.1 1756515 1757552 R hypothetical protein complement(1756515..1757552) Streptococcus pneumoniae R6 933633 NP_359375.1 CDS coaD NC_003098.1 1757536 1758024 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(1757536..1758024) Streptococcus pneumoniae R6 933639 NP_359376.1 CDS spr1784 NC_003098.1 1758014 1758553 R Probable methylase; type II DNA modification methyltransferase complement(1758014..1758553) Streptococcus pneumoniae R6 933637 NP_359377.1 CDS asnA NC_003098.1 1758618 1759616 R catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA complement(1758618..1759616) Streptococcus pneumoniae R6 933629 NP_359379.1 CDS spr1787 NC_003098.1 1759722 1760429 R transmembrane protein; hypothetical protein complement(1759722..1760429) Streptococcus pneumoniae R6 933634 NP_359380.1 CDS yjfA NC_003098.1 1760461 1761219 R rRNA/tRNA methylase complement(1760461..1761219) Streptococcus pneumoniae R6 933626 NP_359381.1 CDS acyP NC_003098.1 1761235 1761513 D catalyzes the hydrolysis of acylphosphate; acylphosphatase 1761235..1761513 Streptococcus pneumoniae R6 933631 NP_359382.1 CDS spr1790 NC_003098.1 1761591 1762517 D involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein 1761591..1762517 Streptococcus pneumoniae R6 933632 NP_359383.1 CDS pflC NC_003098.1 1762592 1763386 R pyruvate-formate lyase activating enzyme complement(1762592..1763386) Streptococcus pneumoniae R6 933619 NP_359384.1 CDS lysA NC_003098.1 1763512 1764762 R diaminopimelate decarboxylase complement(1763512..1764762) Streptococcus pneumoniae R6 933628 NP_359385.1 CDS purR NC_003098.1 1764829 1765656 R pur operon repressor complement(1764829..1765656) Streptococcus pneumoniae R6 933627 NP_359386.1 CDS cbf1 NC_003098.1 1765923 1766927 R cmp-binding-factor 1 complement(1765923..1766927) Streptococcus pneumoniae R6 933622 NP_359387.1 CDS spr1795 NC_003098.1 1766854 1768152 R hypothetical protein complement(1766854..1768152) Streptococcus pneumoniae R6 933621 NP_359388.1 CDS spr1796 NC_003098.1 1768112 1768795 R hypothetical protein complement(1768112..1768795) Streptococcus pneumoniae R6 933613 NP_359389.1 CDS rpe NC_003098.1 1768737 1769393 R ribulose-phosphate 3-epimerase complement(1768737..1769393) Streptococcus pneumoniae R6 933617 NP_359390.1 CDS spr1798 NC_003098.1 1769404 1770282 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(1769404..1770282) Streptococcus pneumoniae R6 933616 NP_359391.1 CDS ksgA NC_003098.1 1770284 1771156 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(1770284..1771156) Streptococcus pneumoniae R6 933610 NP_359392.1 CDS spr1800 NC_003098.1 1771287 1771601 R hypothetical protein complement(1771287..1771601) Streptococcus pneumoniae R6 933615 NP_359393.1 CDS ABC-NBD NC_003098.1 1771588 1772229 R ABC transporter ATP-binding protein complement(1771588..1772229) Streptococcus pneumoniae R6 933614 NP_359394.1 CDS spr1802 NC_003098.1 1772231 1774273 R immunity protein; hypothetical protein complement(1772231..1774273) Streptococcus pneumoniae R6 933608 NP_359395.1 CDS plcR NC_003098.1 1774530 1775429 R transcriptional regulator PlcR complement(1774530..1775429) Streptococcus pneumoniae R6 933612 NP_359396.1 CDS spr1804 NC_003098.1 1775501 1776061 R Primase-related protein; primase-related protein complement(1775501..1776061) Streptococcus pneumoniae R6 933611 NP_359397.1 CDS spr1805 NC_003098.1 1776061 1776834 R hypothetical protein complement(1776061..1776834) Streptococcus pneumoniae R6 933604 NP_359398.1 CDS spr1806 NC_003098.1 1777140 1777805 R cell wall surface anchor family protein complement(1777140..1777805) Streptococcus pneumoniae R6 933609 NP_359399.1 CDS rpmH NC_003098.1 1778068 1778202 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(1778068..1778202) Streptococcus pneumoniae R6 933601 NP_359400.1 CDS aspC NC_003098.1 1778347 1779561 R broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase complement(1778347..1779561) Streptococcus pneumoniae R6 933607 NP_359401.1 CDS spr1809 NC_003098.1 1779717 1780025 R hypothetical protein complement(1779717..1780025) Streptococcus pneumoniae R6 933606 NP_359402.1 CDS spr1810 NC_003098.1 1780109 1780624 D hypothetical protein 1780109..1780624 Streptococcus pneumoniae R6 933599 NP_359403.1 CDS spr1811 NC_003098.1 1780659 1782077 R Cof family protein complement(1780659..1782077) Streptococcus pneumoniae R6 933603 NP_359404.1 CDS ansB NC_003098.1 1782113 1783075 D L-asparaginase 1782113..1783075 Streptococcus pneumoniae R6 933602 YP_008719808.1 CDS spr1812a NC_003098.1 1783072 1783263 R hypothetical protein complement(1783072..1783263) Streptococcus pneumoniae R6 17374513 NP_359405.1 CDS ccpA NC_003098.1 1783327 1784367 R catabolite control protein A complement(1783327..1784367) Streptococcus pneumoniae R6 933600 NP_359406.1 CDS rr11 NC_003098.1 1784762 1785361 R DNA-binding response regulator complement(1784762..1785361) Streptococcus pneumoniae R6 933595 NP_359407.1 CDS hk11 NC_003098.1 1785363 1786460 R sensor histidine kinase complement(1785363..1786460) Streptococcus pneumoniae R6 933598 NP_359408.1 CDS spr1816 NC_003098.1 1786460 1787227 R hypothetical protein complement(1786460..1787227) Streptococcus pneumoniae R6 933597 NP_359409.1 CDS ABC-NBD NC_003098.1 1787199 1788083 R ABC transporter ATP-binding protein complement(1787199..1788083) Streptococcus pneumoniae R6 933591 NP_359410.1 CDS spr1818 NC_003098.1 1788261 1788467 R hypothetical protein complement(1788261..1788467) Streptococcus pneumoniae R6 933596 NP_359411.1 CDS comX2 NC_003098.1 1795146 1795625 R sigma factor; competence-specific global transcription modulator complement(1795146..1795625) Streptococcus pneumoniae R6 933573 NP_359412.1 CDS nusG NC_003098.1 1795747 1796298 R Modulates Rho-dependent transcription termination; transcription antitermination protein NusG complement(1795747..1796298) Streptococcus pneumoniae R6 933572 NP_359413.1 CDS secE NC_003098.1 1796338 1796514 R forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(1796338..1796514) Streptococcus pneumoniae R6 933566 NP_359414.1 CDS rpmG NC_003098.1 1796524 1796676 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 complement(1796524..1796676) Streptococcus pneumoniae R6 933570 NP_359415.1 CDS pbp2a NC_003098.1 1796729 1798924 R penicillin-binding protein 2A complement(1796729..1798924) Streptococcus pneumoniae R6 933569 NP_359416.1 CDS rluD NC_003098.1 1799011 1799886 D ribosomal large subunit pseudouridine synthase D 1799011..1799886 Streptococcus pneumoniae R6 933563 NP_359417.1 CDS gapA NC_003098.1 1799954 1801033 R catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase complement(1799954..1801033) Streptococcus pneumoniae R6 933568 NP_359418.1 CDS spr1826 NC_003098.1 1801138 1802118 R hypothetical protein complement(1801138..1802118) Streptococcus pneumoniae R6 933567 NP_359420.1 CDS transposase_A NC_003098.1 1802664 1803011 R transposase complement(1802664..1803011) Streptococcus pneumoniae R6 933565 NP_359421.1 CDS nadC NC_003098.1 1803124 1804023 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase complement(1803124..1804023) Streptococcus pneumoniae R6 933564 NP_359422.1 CDS spr1830 NC_003098.1 1804233 1805543 D integral membrane protein; hypothetical protein 1804233..1805543 Streptococcus pneumoniae R6 933778 NP_359423.1 CDS spr1831 NC_003098.1 1805909 1806103 R hypothetical protein complement(1805909..1806103) Streptococcus pneumoniae R6 933562 NP_359424.1 CDS spr1832 NC_003098.1 1806563 1807291 R transcription regulator; hypothetical protein complement(1806563..1807291) Streptococcus pneumoniae R6 933801 NP_359425.1 CDS bgl2 NC_003098.1 1807407 1808858 D beta-glucosidase 1807407..1808858 Streptococcus pneumoniae R6 933560 NP_359426.1 CDS ptcC NC_003098.1 1808876 1810171 D PTS system transporter subunit IIC 1808876..1810171 Streptococcus pneumoniae R6 933775 NP_359427.1 CDS ptcB NC_003098.1 1810176 1810484 D PTS system transporter subunit IIB 1810176..1810484 Streptococcus pneumoniae R6 933815 NP_359428.1 CDS ptcA NC_003098.1 1810463 1810789 D PTS system transporter subunit IIA 1810463..1810789 Streptococcus pneumoniae R6 933795 NP_359429.1 CDS adhE NC_003098.1 1811697 1814369 R bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1811697..1814369) Streptococcus pneumoniae R6 933809 NP_359430.1 CDS spr1838 NC_003098.1 1814648 1815058 R hypothetical protein complement(1814648..1815058) Streptococcus pneumoniae R6 933811 NP_359431.1 CDS spr1839 NC_003098.1 1815060 1815488 R protein-tyrosine-phosphatase; phosphotyrosine protein phosphatase complement(1815060..1815488) Streptococcus pneumoniae R6 933856 NP_359432.1 CDS yajC NC_003098.1 1815535 1815834 R member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC complement(1815535..1815834) Streptococcus pneumoniae R6 933824 NP_359433.1 CDS tktA NC_003098.1 1815951 1817927 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(1815951..1817927) Streptococcus pneumoniae R6 933829 NP_359434.1 CDS spr1842 NC_003098.1 1818041 1819132 R L-ascorbate 6-phosphate lactonase complement(1818041..1819132) Streptococcus pneumoniae R6 933878 NP_359435.1 CDS spr1843 NC_003098.1 1819244 1820917 R transcriptional regulator; hypothetical protein complement(1819244..1820917) Streptococcus pneumoniae R6 933847 NP_359436.1 CDS araD NC_003098.1 1821096 1821800 R catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase complement(1821096..1821800) Streptococcus pneumoniae R6 933851 NP_359437.1 CDS sga NC_003098.1 1821802 1822665 R L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase complement(1821802..1822665) Streptococcus pneumoniae R6 933901 NP_359438.2 CDS ulaD NC_003098.1 1822669 1823334 R catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase complement(1822669..1823334) Streptococcus pneumoniae R6 933867 NP_359439.1 CDS PTS-EII NC_003098.1 1823351 1823836 R PTS system transporter subunit IIA complement(1823351..1823836) Streptococcus pneumoniae R6 933871 NP_359440.1 CDS PTS-EII NC_003098.1 1823913 1824194 R PTS system transporter subunit IIB complement(1823913..1824194) Streptococcus pneumoniae R6 933915 NP_359441.2 CDS ulaA NC_003098.1 1824217 1825674 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(1824217..1825674) Streptococcus pneumoniae R6 933892 NP_359442.1 CDS spr1850 NC_003098.1 1825805 1826428 R hypothetical protein complement(1825805..1826428) Streptococcus pneumoniae R6 933898 NP_359443.1 CDS spr1851 NC_003098.1 1826479 1827465 R hypothetical protein complement(1826479..1827465) Streptococcus pneumoniae R6 933938 NP_359444.1 CDS spr1852 NC_003098.1 1827484 1828314 R Similar to Bacillus subtilis SpoIIIJ; SpoIIIJ family protein complement(1827484..1828314) Streptococcus pneumoniae R6 933908 NP_359445.1 CDS rnpA NC_003098.1 1828283 1828654 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(1828283..1828654) Streptococcus pneumoniae R6 933911 NP_359446.1 CDS ackA NC_003098.1 1828803 1829993 R AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase complement(1828803..1829993) Streptococcus pneumoniae R6 933975 NP_359447.1 CDS spr1855 NC_003098.1 1830044 1830997 R hypothetical protein complement(1830044..1830997) Streptococcus pneumoniae R6 933926 NP_359450.1 CDS spr1858 NC_003098.1 1831789 1832202 R hypothetical protein complement(1831789..1832202) Streptococcus pneumoniae R6 933961 NP_359451.1 CDS spr1859 NC_003098.1 1832180 1832686 R Competence induced; related to comYD; hypothetical protein complement(1832180..1832686) Streptococcus pneumoniae R6 933974 NP_359452.1 CDS cglD NC_003098.1 1832869 1833351 R Competence induced; comG-like protein D; competence protein CglD complement(1832869..1833351) Streptococcus pneumoniae R6 933985 NP_359453.1 CDS cglC NC_003098.1 1833266 1833592 R Competence induced; comG-like protein C; competence protein CglC complement(1833266..1833592) Streptococcus pneumoniae R6 933977 NP_359454.1 CDS cglB NC_003098.1 1833594 1834685 R Competence induced; comG-like protein B; competence protein CglB complement(1833594..1834685) Streptococcus pneumoniae R6 933980 NP_359455.1 CDS cglA NC_003098.1 1834558 1835499 R Competence induced; comG-like protein A; Also known as cilD; competence protein CglA complement(1834558..1835499) Streptococcus pneumoniae R6 933989 NP_359456.1 CDS spr1865 NC_003098.1 1835575 1835946 R DNA binding protein; hypothetical protein complement(1835575..1835946) Streptococcus pneumoniae R6 933983 NP_359457.1 CDS adh NC_003098.1 1836091 1837149 R zinc-containing alcohol dehydrogenase complement(1836091..1837149) Streptococcus pneumoniae R6 933984 NP_359458.1 CDS nagA NC_003098.1 1837312 1838463 R N-acetylglucosamine-6-phosphate deacetylase complement(1837312..1838463) Streptococcus pneumoniae R6 933992 NP_359459.1 CDS spr1868 NC_003098.1 1838616 1840433 R hypothetical protein complement(1838616..1840433) Streptococcus pneumoniae R6 933986 NP_359460.1 CDS tgt NC_003098.1 1840531 1841673 R Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase complement(1840531..1841673) Streptococcus pneumoniae R6 933988 NP_359461.1 CDS spr1870 NC_003098.1 1841803 1842660 D hypothetical protein 1841803..1842660 Streptococcus pneumoniae R6 933994 NP_359465.1 CDS marR NC_003098.1 1843781 1844119 R MarR family transcriptional regulator complement(1843781..1844119) Streptococcus pneumoniae R6 933993 NP_359466.1 CDS spr1875 NC_003098.1 1844525 1845667 R Probable group B streptococcal surface immunogenic protein; hypothetical protein complement(1844525..1845667) Streptococcus pneumoniae R6 934001 NP_359467.1 CDS spr1876 NC_003098.1 1845833 1846453 R Low similarity to phosphoglycolate phosphatase; hypothetical protein complement(1845833..1846453) Streptococcus pneumoniae R6 933995 NP_359468.1 CDS MATE_transporter NC_003098.1 1846457 1847737 R MATE family transporter complement(1846457..1847737) Streptococcus pneumoniae R6 933996 NP_359469.1 CDS thrC NC_003098.1 1847798 1849282 R catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase complement(1847798..1849282) Streptococcus pneumoniae R6 934003 NP_359470.1 CDS spr1879 NC_003098.1 1849358 1850635 R hypothetical protein complement(1849358..1850635) Streptococcus pneumoniae R6 933999 NP_359471.1 CDS spr1880 NC_003098.1 1857099 1857533 R Low similarity to cytidine/deoxycytidylate deaminases; cytidine/deoxycytidylate deaminase complement(1857099..1857533) Streptococcus pneumoniae R6 934018 NP_359472.1 CDS gltX NC_003098.1 1857547 1859007 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(1857547..1859007) Streptococcus pneumoniae R6 934019 NP_359473.1 CDS pgi NC_003098.1 1859131 1860480 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(1859131..1860480) Streptococcus pneumoniae R6 934060 NP_359474.1 CDS spr1883 NC_003098.1 1860467 1860646 R hypothetical protein complement(1860467..1860646) Streptococcus pneumoniae R6 934022 NP_359475.1 CDS guaA NC_003098.1 1860650 1861387 R glutamine amidotransferase complement(1860650..1861387) Streptococcus pneumoniae R6 934043 NP_359476.1 CDS ABC-NP NC_003098.1 1861478 1863289 R ABC transporter ATP-binding protein/permease complement(1861478..1863289) Streptococcus pneumoniae R6 934071 NP_359478.1 CDS ABC-NP NC_003098.1 1864031 1865725 R ABC transporter ATP-binding protein/permease complement(1864031..1865725) Streptococcus pneumoniae R6 934054 NP_359479.1 CDS hexA NC_003098.1 1865872 1868445 R This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS complement(1865872..1868445) Streptococcus pneumoniae R6 934113 NP_359480.1 CDS argR NC_003098.1 1868457 1868903 R arginine repressor ArgR complement(1868457..1868903) Streptococcus pneumoniae R6 934064 NP_359481.1 CDS argS NC_003098.1 1869051 1870742 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1869051..1870742 Streptococcus pneumoniae R6 934066 NP_359482.1 CDS IS1381 NC_003098.1 1871057 1871446 R tranposase complement(1871057..1871446) Streptococcus pneumoniae R6 934140 NP_359483.1 CDS spr1892 NC_003098.1 1871577 1872086 D hypothetical protein 1871577..1872086 Streptococcus pneumoniae R6 934133 NP_359484.1 CDS phoP_pnpR NC_003098.1 1872170 1872877 D response regulator 1872170..1872877 Streptococcus pneumoniae R6 934134 NP_359485.1 CDS phoR-pnpS NC_003098.1 1872878 1874209 D sensor histidine kinase PnpS 1872878..1874209 Streptococcus pneumoniae R6 934137 NP_359486.1 CDS pstS NC_003098.1 1874313 1875251 D phosphate ABC transporter substrate+B766-binding protein 1874313..1875251 Streptococcus pneumoniae R6 934120 NP_359487.1 CDS pstC NC_003098.1 1875369 1876232 D phosphate ABC transporter permease 1875369..1876232 Streptococcus pneumoniae R6 934126 NP_359488.1 CDS pstA NC_003098.1 1876225 1877040 D phosphate ABC transporter permease 1876225..1877040 Streptococcus pneumoniae R6 934117 NP_359489.1 CDS pstB NC_003098.1 1877042 1877794 D ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1877042..1877794 Streptococcus pneumoniae R6 934112 NP_359490.1 CDS phoU NC_003098.1 1877809 1878459 D phosphate transporter PhoU 1877809..1878459 Streptococcus pneumoniae R6 934135 NP_359492.1 CDS spr1901 NC_003098.1 1879066 1879584 R Possible transcriptional regulator; transcriptional regulator complement(1879066..1879584) Streptococcus pneumoniae R6 934138 NP_359493.1 CDS gpsA NC_003098.1 1879718 1880734 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1879718..1880734 Streptococcus pneumoniae R6 934131 NP_359494.1 CDS galU NC_003098.1 1880756 1881655 D UTP-glucose-1-phosphate uridylyltransferase 1880756..1881655 Streptococcus pneumoniae R6 934139 NP_359495.1 CDS spr1904 NC_003098.1 1881722 1882402 R hypothetical protein complement(1881722..1882402) Streptococcus pneumoniae R6 934116 NP_359496.1 CDS spr1905 NC_003098.1 1882383 1882928 R Similar to 5-formyltetrahydrofolate cyclo-ligase; 5-formyltetrahydrofolate cyclo-ligase complement(1882383..1882928) Streptococcus pneumoniae R6 934123 NP_359497.1 CDS hipO NC_003098.1 1882934 1884064 R hypothetical protein complement(1882934..1884064) Streptococcus pneumoniae R6 934136 NP_359498.1 CDS dapD NC_003098.1 1884132 1884830 R 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(1884132..1884830) Streptococcus pneumoniae R6 934124 NP_359499.1 CDS spr1908 NC_003098.1 1885060 1886193 R hypothetical protein complement(1885060..1886193) Streptococcus pneumoniae R6 934127 NP_359500.1 CDS pbp1b NC_003098.1 1886036 1888501 R penicillin-binding protein 1B complement(1886036..1888501) Streptococcus pneumoniae R6 934893 NP_359501.1 CDS tyrS NC_003098.1 1888643 1889899 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1888643..1889899 Streptococcus pneumoniae R6 934128 NP_359502.1 CDS ctpC NC_003098.1 1889977 1892049 R metal/cation transporter P-type ATPase complement(1889977..1892049) Streptococcus pneumoniae R6 934119 NP_359503.1 CDS spr1912 NC_003098.1 1892042 1892353 R hypothetical protein complement(1892042..1892353) Streptococcus pneumoniae R6 934129 NP_359504.1 CDS rrmA NC_003098.1 1892472 1893320 D rRNA (guanine-N1-)-methyltransferase 1892472..1893320 Streptococcus pneumoniae R6 934132 NP_359505.1 CDS spr1914 NC_003098.1 1893836 1894042 R hypothetical protein complement(1893836..1894042) Streptococcus pneumoniae R6 934111 NP_359506.1 CDS spr1915 NC_003098.1 1894119 1894691 D hypothetical protein 1894119..1894691 Streptococcus pneumoniae R6 934130 NP_359507.1 CDS malP NC_003098.1 1895736 1897994 R maltodextrin phosphorylase complement(1895736..1897994) Streptococcus pneumoniae R6 932789 NP_359508.1 CDS malM NC_003098.1 1898020 1899537 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(1898020..1899537) Streptococcus pneumoniae R6 934839 NP_359509.1 CDS malX NC_003098.1 1900087 1901358 D maltose/maltodextrin ABC transporter substrate+B616-binding protein 1900087..1901358 Streptococcus pneumoniae R6 932974 NP_359510.1 CDS malC NC_003098.1 1901454 1902761 D maltodextrin ABC transporter permease 1901454..1902761 Streptococcus pneumoniae R6 934838 NP_359511.1 CDS malD NC_003098.1 1902742 1903605 D maltodextrin ABC transporter permease 1902742..1903605 Streptococcus pneumoniae R6 932952 NP_359512.1 CDS malA NC_003098.1 1903858 1904658 D MalA protein 1903858..1904658 Streptococcus pneumoniae R6 932980 NP_359513.1 CDS malR NC_003098.1 1904668 1905654 D maltose operon transcriptional repressor 1904668..1905654 Streptococcus pneumoniae R6 934853 NP_359514.1 CDS spr1923 NC_003098.1 1905946 1906887 R hypothetical protein complement(1905946..1906887) Streptococcus pneumoniae R6 933407 NP_359515.1 CDS aspS NC_003098.1 1906865 1908628 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(1906865..1908628) Streptococcus pneumoniae R6 934841 NP_359516.1 CDS spr1925 NC_003098.1 1908980 1909210 R hypothetical protein complement(1908980..1909210) Streptococcus pneumoniae R6 933582 NP_359517.1 CDS spr1926 NC_003098.1 1909228 1909869 R hypothetical protein complement(1909228..1909869) Streptococcus pneumoniae R6 933018 NP_359518.1 CDS spr1927 NC_003098.1 1909881 1910621 R hypothetical protein complement(1909881..1910621) Streptococcus pneumoniae R6 933014 NP_359519.1 CDS spr1928 NC_003098.1 1910618 1910818 R hypothetical protein complement(1910618..1910818) Streptococcus pneumoniae R6 934121 NP_359520.1 CDS spr1929 NC_003098.1 1910815 1911030 R transcriptional repressor protein; transcriptional regulator complement(1910815..1911030) Streptococcus pneumoniae R6 934842 NP_359521.1 CDS spr1930 NC_003098.1 1911031 1911495 R hypothetical protein complement(1911031..1911495) Streptococcus pneumoniae R6 933027 NP_359522.1 CDS hisS NC_003098.1 1911671 1912960 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(1911671..1912960) Streptococcus pneumoniae R6 934840 NP_359523.1 CDS spr1932 NC_003098.1 1913038 1914285 R permease; hypothetical protein complement(1913038..1914285) Streptococcus pneumoniae R6 933004 NP_359524.1 CDS rgg NC_003098.1 1914475 1915326 R positive transcriptional regulator of glucosyltransferase and Spp phenotype complement(1914475..1915326) Streptococcus pneumoniae R6 932938 NP_359525.1 CDS spr1934 NC_003098.1 1915450 1915791 D hypothetical protein 1915450..1915791 Streptococcus pneumoniae R6 933034 NP_359526.1 CDS ilvD NC_003098.1 1916000 1917703 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(1916000..1917703) Streptococcus pneumoniae R6 934050 NP_359527.1 CDS tktC NC_003098.1 1917936 1918868 R transketolase C-terminal subunit complement(1917936..1918868) Streptococcus pneumoniae R6 934843 NP_359528.1 CDS tktN NC_003098.1 1918865 1919722 R transketolase N-terminal section complement(1918865..1919722) Streptococcus pneumoniae R6 933053 NP_359529.1 CDS ulaA NC_003098.1 1919726 1921072 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(1919726..1921072) Streptococcus pneumoniae R6 933025 NP_359530.1 CDS spr1939 NC_003098.1 1921085 1921369 R PTS system transporter subunit IIB complement(1921085..1921369) Streptococcus pneumoniae R6 934844 NP_359531.1 CDS spr1940 NC_003098.1 1921373 1923403 R Probable transcriptional antiterminator, bglG family; hypothetical protein complement(1921373..1923403) Streptococcus pneumoniae R6 933065 NP_359532.1 CDS spr1941 NC_003098.1 1923594 1924601 D hypothetical protein 1923594..1924601 Streptococcus pneumoniae R6 933064 NP_359533.1 CDS spr1942 NC_003098.1 1924604 1924804 D hypothetical protein 1924604..1924804 Streptococcus pneumoniae R6 933036 NP_359534.1 CDS rpmF NC_003098.1 1924956 1925138 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1924956..1925138 Streptococcus pneumoniae R6 933000 NP_359535.1 CDS rpmG NC_003098.1 1925154 1925303 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1925154..1925303 Streptococcus pneumoniae R6 934845 NP_359536.1 CDS pcpA NC_003098.1 1925783 1927855 R choline binding protein PcpA complement(1925783..1927855) Streptococcus pneumoniae R6 933069 NP_359537.1 CDS spr1946 NC_003098.1 1928212 1928781 D hypothetical protein 1928212..1928781 Streptococcus pneumoniae R6 933077 NP_359538.1 CDS IS1381 NC_003098.1 1928807 1929196 D tranposase 1928807..1929196 Streptococcus pneumoniae R6 934847 NP_359540.1 CDS spr1949 NC_003098.1 1929900 1931780 R glycosyl hydrolase-like protein complement(1929900..1931780) Streptococcus pneumoniae R6 934846 NP_359541.1 CDS spr1950 NC_003098.1 1931774 1932655 R sugar operon regulatory protein; ROK family protein complement(1931774..1932655) Streptococcus pneumoniae R6 933076 NP_359542.1 CDS spr1951 NC_003098.1 1932727 1935387 R Probable sugar hydrolase; hypothetical protein complement(1932727..1935387) Streptococcus pneumoniae R6 933083 NP_359543.1 CDS spr1952 NC_003098.1 1935463 1936767 R hypothetical protein complement(1935463..1936767) Streptococcus pneumoniae R6 933101 NP_359544.1 CDS spr1953 NC_003098.1 1936914 1938998 D Similar to a sugar hydrolase in Lactococcus lactis subsp. lactis; hypothetical protein 1936914..1938998 Streptococcus pneumoniae R6 933282 NP_359545.1 CDS spr1954 NC_003098.1 1939038 1940789 R hypothetical protein complement(1939038..1940789) Streptococcus pneumoniae R6 933075 NP_359548.1 CDS arcB NC_003098.1 1942769 1943785 D catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 1942769..1943785 Streptococcus pneumoniae R6 932991 NP_359549.1 CDS arcC NC_003098.1 1943950 1944897 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1943950..1944897 Streptococcus pneumoniae R6 934851 NP_359550.1 CDS spr1959 NC_003098.1 1945106 1946617 D hypothetical protein 1945106..1946617 Streptococcus pneumoniae R6 933363 NP_359551.1 CDS spr1960 NC_003098.1 1946639 1947970 D Probable Xaa-His dipeptidase; hypothetical protein 1946639..1947970 Streptococcus pneumoniae R6 933289 NP_359552.1 CDS spr1961 NC_003098.1 1948375 1948665 R hypothetical protein complement(1948375..1948665) Streptococcus pneumoniae R6 933261 NP_359553.1 CDS spr1962 NC_003098.1 1949304 1950203 R Probable member of SPFH domain/Band 7 family; hypothetical protein complement(1949304..1950203) Streptococcus pneumoniae R6 933066 NP_359554.1 CDS adh2 NC_003098.1 1950333 1951484 R iron-containing alcohol dehydrogenase complement(1950333..1951484) Streptococcus pneumoniae R6 933050 NP_359555.1 CDS fucI NC_003098.1 1951630 1953396 R catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase complement(1951630..1953396) Streptococcus pneumoniae R6 933146 NP_359556.1 CDS spr1965 NC_003098.1 1953453 1956569 R fucolectin-related protein complement(1953453..1956569) Streptococcus pneumoniae R6 933903 NP_359557.1 CDS spr1966 NC_003098.1 1956579 1958873 R hypothetical protein complement(1956579..1958873) Streptococcus pneumoniae R6 934848 NP_359558.1 CDS PTS-EII NC_003098.1 1958932 1959732 R PTS system transporter subunit IID complement(1958932..1959732) Streptococcus pneumoniae R6 933119 NP_359559.1 CDS PTS-EII NC_003098.1 1959729 1960502 R PTS system transporter subunit IIC complement(1959729..1960502) Streptococcus pneumoniae R6 933265 NP_359560.1 CDS PTS-EII NC_003098.1 1960527 1960997 R PTS system transporter subunit IIB complement(1960527..1960997) Streptococcus pneumoniae R6 934849 NP_359561.1 CDS PTS-EII NC_003098.1 1960988 1961434 R PTS system transporter subunit IIA complement(1960988..1961434) Streptococcus pneumoniae R6 933110 NP_359562.1 CDS fucU NC_003098.1 1961412 1961852 R fucose pathway protein complement(1961412..1961852) Streptococcus pneumoniae R6 933886 NP_359563.1 CDS fucA NC_003098.1 1961864 1962517 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(1961864..1962517) Streptococcus pneumoniae R6 932993 NP_359564.1 CDS fcsK NC_003098.1 1962617 1964065 R fucose kinase complement(1962617..1964065) Streptococcus pneumoniae R6 932925 NP_359565.1 CDS fcsR NC_003098.1 1964196 1964969 D fucose operon repressor 1964196..1964969 Streptococcus pneumoniae R6 934850 NP_359566.1 CDS adcA NC_003098.1 1966098 1967603 R zinc ABC transporter substrate-binding protein complement(1966098..1967603) Streptococcus pneumoniae R6 933277 NP_359567.1 CDS adcB NC_003098.1 1967613 1968449 R zinc ABC transporter permease complement(1967613..1968449) Streptococcus pneumoniae R6 934852 NP_359568.1 CDS adcC NC_003098.1 1968412 1969116 R ABC transporter ATPase complement(1968412..1969116) Streptococcus pneumoniae R6 933425 NP_359569.1 CDS adcR NC_003098.1 1969116 1969616 R adc operon repressor AdcR complement(1969116..1969616) Streptococcus pneumoniae R6 933868 NP_359570.1 CDS dltD NC_003098.1 1969711 1970994 R poly D-alanine transfer protein complement(1969711..1970994) Streptococcus pneumoniae R6 933943 NP_359571.1 CDS dltC NC_003098.1 1970972 1971211 R D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 complement(1970972..1971211) Streptococcus pneumoniae R6 934854 NP_359572.1 CDS dltB NC_003098.1 1971225 1972469 R D-alanine transfer from Dcp to undecaprenol-phosphate; activated D-alanine transport protein complement(1971225..1972469) Streptococcus pneumoniae R6 933707 NP_359573.1 CDS dltA NC_003098.1 1972466 1973932 R transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 complement(1972466..1973932) Streptococcus pneumoniae R6 934087 NP_359574.1 CDS spr1983 NC_003098.1 1974482 1975660 R hypothetical protein complement(1974482..1975660) Streptococcus pneumoniae R6 933708 NP_359577.1 CDS spr1986 NC_003098.1 1978504 1979091 D hypothetical protein 1978504..1979091 Streptococcus pneumoniae R6 933486 NP_359578.1 CDS spr1987 NC_003098.1 1979178 1979381 R hypothetical protein complement(1979178..1979381) Streptococcus pneumoniae R6 934871 NP_359579.1 CDS glpF NC_003098.1 1979572 1980276 R glycerol uptake facilitator protein complement(1979572..1980276) Streptococcus pneumoniae R6 933711 NP_359582.1 CDS glpK NC_003098.1 1982216 1983724 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(1982216..1983724) Streptococcus pneumoniae R6 933712 NP_359583.1 CDS spr1992 NC_003098.1 1983883 1985310 R hypothetical protein complement(1983883..1985310) Streptococcus pneumoniae R6 934088 NP_359584.1 CDS hslO NC_003098.1 1985475 1986347 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 1985475..1986347 Streptococcus pneumoniae R6 934856 NP_359585.1 CDS spr1994 NC_003098.1 1986304 1987314 D Falls into the same paralogous family as dihydroorotate dehydrogenase; hypothetical protein 1986304..1987314 Streptococcus pneumoniae R6 933713 NP_359586.1 CDS pspC NC_003098.1 1987544 1989649 R choline binding protein A complement(1987544..1989649) Streptococcus pneumoniae R6 933487 NP_359587.1 CDS spr1996 NC_003098.1 1989728 1990255 R hypothetical protein complement(1989728..1990255) Streptococcus pneumoniae R6 934857 NP_359588.1 CDS hk06 NC_003098.1 1990338 1991669 R histidine kinase complement(1990338..1991669) Streptococcus pneumoniae R6 933715 NP_359589.1 CDS rr06 NC_003098.1 1991666 1992319 R response regulator complement(1991666..1992319) Streptococcus pneumoniae R6 934089 NP_359592.1 CDS ctsR NC_003098.1 1995395 1995916 R transcriptional regulator CtsR complement(1995395..1995916) Streptococcus pneumoniae R6 933717 NP_359593.1 CDS ABC-NBD NC_003098.1 1995972 1996700 R ABC transporter ATP-binding protein complement(1995972..1996700) Streptococcus pneumoniae R6 934094 NP_359594.1 CDS spr2003 NC_003098.1 1996700 1997707 R ABC transporter substrate-binding protein complement(1996700..1997707) Streptococcus pneumoniae R6 934861 NP_359595.1 CDS ABC-MSP NC_003098.1 1997745 1998506 R ABC transporter permease complement(1997745..1998506) Streptococcus pneumoniae R6 933718 NP_359596.1 CDS spr2005 NC_003098.1 1998466 1998756 R hypothetical protein complement(1998466..1998756) Streptococcus pneumoniae R6 934092 NP_359597.1 CDS cbpD NC_003098.1 1999012 2000358 R choline binding protein D complement(1999012..2000358) Streptococcus pneumoniae R6 934859 NP_359598.1 CDS spr2007 NC_003098.1 2000447 2000713 R hypothetical protein complement(2000447..2000713) Streptococcus pneumoniae R6 933719 NP_359599.1 CDS dnaC NC_003098.1 2000715 2002067 R unwinds double stranded DNA; replicative DNA helicase complement(2000715..2002067) Streptococcus pneumoniae R6 933489 NP_359600.1 CDS rplI NC_003098.1 2002111 2002563 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(2002111..2002563) Streptococcus pneumoniae R6 934865 NP_359601.1 CDS spr2010 NC_003098.1 2002560 2004533 R Probable member of DHH superfamily; DHH subfamily 1 protein complement(2002560..2004533) Streptococcus pneumoniae R6 933720 NP_359602.1 CDS spr2011 NC_003098.1 2004669 2005217 R Probable member of ribosomal protein S30AE family; ribosomal subunit interface protein complement(2004669..2005217) Streptococcus pneumoniae R6 934097 NP_359603.1 CDS comFC NC_003098.1 2005297 2005959 R competence protein ComF complement(2005297..2005959) Streptococcus pneumoniae R6 934860 NP_359604.1 CDS comFA NC_003098.1 2005956 2007254 R helicase complement(2005956..2007254) Streptococcus pneumoniae R6 933722 NP_359605.1 CDS spr2014 NC_003098.1 2007310 2007945 D hypothetical protein 2007310..2007945 Streptococcus pneumoniae R6 934091 NP_359606.1 CDS cycK NC_003098.1 2008230 2009150 D cysteine synthase 2008230..2009150 Streptococcus pneumoniae R6 933723 NP_359607.1 CDS transposase_G NC_003098.1 2009347 2009616 R hypothetical protein complement(2009347..2009616) Streptococcus pneumoniae R6 933490 NP_359610.1 CDS tsf NC_003098.1 2010734 2011774 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(2010734..2011774) Streptococcus pneumoniae R6 933725 NP_359611.1 CDS rpsB NC_003098.1 2011840 2012619 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(2011840..2012619) Streptococcus pneumoniae R6 934093 NP_359612.1 CDS gsp-781 NC_003098.1 2012843 2014021 R general stress protein GSP-781 complement(2012843..2014021) Streptococcus pneumoniae R6 933726 NP_359613.1 CDS mreD NC_003098.1 2014115 2014609 R rod shpae-determining protein MreD complement(2014115..2014609) Streptococcus pneumoniae R6 933491 NP_359614.1 CDS mreC NC_003098.1 2014609 2015427 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(2014609..2015427) Streptococcus pneumoniae R6 934863 NP_359615.1 CDS ABC-MSP NC_003098.1 2015486 2016280 R ABC transporter permease complement(2015486..2016280) Streptococcus pneumoniae R6 933727 NP_359616.1 CDS cbiO NC_003098.1 2016273 2017112 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2016273..2017112) Streptococcus pneumoniae R6 934095 NP_359617.1 CDS cbiO NC_003098.1 2017097 2017924 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2017097..2017924) Streptococcus pneumoniae R6 934864 NP_359618.1 CDS pgsA NC_003098.1 2017921 2018466 R CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase complement(2017921..2018466) Streptococcus pneumoniae R6 933728 NP_359619.1 CDS spr2028 NC_003098.1 2018477 2019307 R hypothetical protein complement(2018477..2019307) Streptococcus pneumoniae R6 934098 NP_359620.1 CDS spr2029 NC_003098.1 2019340 2020623 R Probable protease/peptidase; hypothetical protein complement(2019340..2020623) Streptococcus pneumoniae R6 934872 NP_359621.1 CDS spr2030 NC_003098.1 2020620 2021870 R hypothetical protein complement(2020620..2021870) Streptococcus pneumoniae R6 933729 NP_359622.1 CDS spr2031 NC_003098.1 2022029 2022397 D hypothetical protein 2022029..2022397 Streptococcus pneumoniae R6 934101 NP_359623.1 CDS recF NC_003098.1 2022400 2023497 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2022400..2023497 Streptococcus pneumoniae R6 934866 NP_359624.1 CDS imdH NC_003098.1 2023548 2025026 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2023548..2025026) Streptococcus pneumoniae R6 933730 NP_359625.1 CDS trpS NC_003098.1 2025178 2026203 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II complement(2025178..2026203) Streptococcus pneumoniae R6 933492 NP_359626.1 CDS ABC-NBD NC_003098.1 2026409 2028031 D ABC transporter ATP-binding protein 2026409..2028031 Streptococcus pneumoniae R6 934867 NP_359627.1 CDS spr2036 NC_003098.1 2028093 2030645 D ABC transporter permease 2028093..2030645 Streptococcus pneumoniae R6 933731 NP_359631.1 CDS spr2040 NC_003098.1 2032457 2032999 D Probable transcriptional regulator of TetR family; hypothetical protein 2032457..2032999 Streptococcus pneumoniae R6 934096 NP_359632.1 CDS comE NC_003098.1 2033242 2033994 R Required for induction of competence; response regulator complement(2033242..2033994) Streptococcus pneumoniae R6 933733 NP_359633.1 CDS comD NC_003098.1 2033991 2035316 R Required for induction of competence; sensor histidine kinase ComD complement(2033991..2035316) Streptococcus pneumoniae R6 934103 NP_359634.1 CDS comC NC_003098.1 2035337 2035462 R competence stimulating peptide complement(2035337..2035462) Streptococcus pneumoniae R6 934870 NP_359635.1 CDS spr2044 NC_003098.1 2035744 2036223 R SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(2035744..2036223) Streptococcus pneumoniae R6 933736 NP_359636.1 CDS sphtra NC_003098.1 2036394 2037587 D serine protease 2036394..2037587 Streptococcus pneumoniae R6 934102 NP_359637.1 CDS spo0J NC_003098.1 2037645 2038403 D chromosome segregation protein 2037645..2038403 Streptococcus pneumoniae R6 933738 sprt01 tRNA tRNA-Glu1 NC_003098.1 14827 14898 D tRNA-Glu 14827..14898 Streptococcus pneumoniae R6 933466 sprt02 tRNA tRNA-Ala1 NC_003098.1 16748 16820 D tRNA-Ala 16748..16820 Streptococcus pneumoniae R6 933675 sprt03 tRNA tRNA-Asn1 NC_003098.1 20044 20117 D tRNA-Asn 20044..20117 Streptococcus pneumoniae R6 932819 sprt04 tRNA tRNA-Tyr1 NC_003098.1 759414 759494 D tRNA-Tyr 759414..759494 Streptococcus pneumoniae R6 934302 sprt05 tRNA tRNA-Gln1 NC_003098.1 759504 759575 D tRNA-Gln 759504..759575 Streptococcus pneumoniae R6 934301 sprt06 tRNA tRNA-Ser1 NC_003098.1 774137 774224 R tRNA-Ser complement(774137..774224) Streptococcus pneumoniae R6 934322 sprt07 tRNA tRNA-Thr1 NC_003098.1 904864 904936 D tRNA-Thr 904864..904936 Streptococcus pneumoniae R6 933842 sprt08 tRNA tRNA-Arg1 NC_003098.1 1131546 1131617 R tRNA-Arg complement(1131546..1131617) Streptococcus pneumoniae R6 932814 sprt09 tRNA tRNA-Arg2 NC_003098.1 1173377 1173448 R tRNA-Arg complement(1173377..1173448) Streptococcus pneumoniae R6 933501 sprt10 tRNA tRNA-Leu1 NC_003098.1 1421994 1422079 R tRNA-Leu complement(1421994..1422079) Streptococcus pneumoniae R6 933839 sprt11 tRNA tRNA-Lys1 NC_003098.1 1590539 1590611 D tRNA-Lys 1590539..1590611 Streptococcus pneumoniae R6 933808 sprt12 tRNA tRNA-Ser2 NC_003098.1 1690783 1690870 R tRNA-Ser complement(1690783..1690870) Streptococcus pneumoniae R6 932939 sprt13 tRNA tRNA-Ile1 NC_003098.1 1690877 1690950 R tRNA-Ile complement(1690877..1690950) Streptococcus pneumoniae R6 933872 sprt14 tRNA tRNA-Gly1 NC_003098.1 1690986 1691056 R tRNA-Gly complement(1690986..1691056) Streptococcus pneumoniae R6 933434 sprt15 tRNA tRNA-Phe1 NC_003098.1 1691076 1691148 R tRNA-Phe complement(1691076..1691148) Streptococcus pneumoniae R6 933275 sprt16 tRNA tRNA-Met1 NC_003098.1 1691152 1691225 R tRNA-Met complement(1691152..1691225) Streptococcus pneumoniae R6 933222 sprt17 tRNA tRNA-Ser3 NC_003098.1 1691239 1691328 R tRNA-Ser complement(1691239..1691328) Streptococcus pneumoniae R6 933479 sprt18 tRNA tRNA-Met2 NC_003098.1 1691339 1691412 R tRNA-Met complement(1691339..1691412) Streptococcus pneumoniae R6 933742 sprt19 tRNA tRNA-Met3 NC_003098.1 1691426 1691499 R tRNA-Met complement(1691426..1691499) Streptococcus pneumoniae R6 933594 sprt20 tRNA tRNA-Pro1 NC_003098.1 1691505 1691578 R tRNA-Pro complement(1691505..1691578) Streptococcus pneumoniae R6 933818 sprt21 tRNA tRNA-Arg3 NC_003098.1 1691594 1691667 R tRNA-Arg complement(1691594..1691667) Streptococcus pneumoniae R6 932920 sprt22 tRNA tRNA-Leu2 NC_003098.1 1691677 1691762 R tRNA-Leu complement(1691677..1691762) Streptococcus pneumoniae R6 933042 sprt23 tRNA tRNA-Gly2 NC_003098.1 1691770 1691841 R tRNA-Gly complement(1691770..1691841) Streptococcus pneumoniae R6 933423 sprt24 tRNA tRNA-Thr2 NC_003098.1 1691864 1691936 R tRNA-Thr complement(1691864..1691936) Streptococcus pneumoniae R6 933850 sprt25 tRNA tRNA-Leu3 NC_003098.1 1691955 1692036 R tRNA-Leu complement(1691955..1692036) Streptococcus pneumoniae R6 932907 sprt26 tRNA tRNA-Lys2 NC_003098.1 1692042 1692114 R tRNA-Lys complement(1692042..1692114) Streptococcus pneumoniae R6 933625 sprt27 tRNA tRNA-Asp1 NC_003098.1 1692139 1692211 R tRNA-Asp complement(1692139..1692211) Streptococcus pneumoniae R6 933439 sprt28 tRNA tRNA-Val1 NC_003098.1 1692214 1692286 R tRNA-Val complement(1692214..1692286) Streptococcus pneumoniae R6 933740 sprt29 tRNA tRNA-Ala2 NC_003098.1 1695509 1695581 R tRNA-Ala complement(1695509..1695581) Streptococcus pneumoniae R6 933089 sprt30 tRNA tRNA-Glu2 NC_003098.1 1697431 1697502 R tRNA-Glu complement(1697431..1697502) Streptococcus pneumoniae R6 933358 sprt31 tRNA tRNA-Cys NC_003098.1 1752048 1752118 D tRNA-Cys 1752048..1752118 Streptococcus pneumoniae R6 933640 sprt32 tRNA tRNA-Pro2 NC_003098.1 1789055 1789128 R tRNA-Pro complement(1789055..1789128) Streptococcus pneumoniae R6 933589 sprt33 tRNA tRNA-Arg4 NC_003098.1 1789144 1789217 R tRNA-Arg complement(1789144..1789217) Streptococcus pneumoniae R6 933592 sprt34 tRNA tRNA-Leu4 NC_003098.1 1789227 1789312 R tRNA-Leu complement(1789227..1789312) Streptococcus pneumoniae R6 933590 sprt35 tRNA tRNA-Gly3 NC_003098.1 1789320 1789391 R tRNA-Gly complement(1789320..1789391) Streptococcus pneumoniae R6 933585 sprt36 tRNA tRNA-Thr3 NC_003098.1 1789414 1789486 R tRNA-Thr complement(1789414..1789486) Streptococcus pneumoniae R6 933587 sprt37 tRNA tRNA-Leu5 NC_003098.1 1789505 1789586 R tRNA-Leu complement(1789505..1789586) Streptococcus pneumoniae R6 933586 sprt38 tRNA tRNA-Lys3 NC_003098.1 1789592 1789664 R tRNA-Lys complement(1789592..1789664) Streptococcus pneumoniae R6 933579 sprt39 tRNA tRNA-Asp2 NC_003098.1 1789689 1789761 R tRNA-Asp complement(1789689..1789761) Streptococcus pneumoniae R6 933583 sprt40 tRNA tRNA-Val2 NC_003098.1 1789764 1789836 R tRNA-Val complement(1789764..1789836) Streptococcus pneumoniae R6 933581 sprt41 tRNA tRNA-Ala3 NC_003098.1 1793059 1793131 R tRNA-Ala complement(1793059..1793131) Streptococcus pneumoniae R6 933576 sprt42 tRNA tRNA-Glu3 NC_003098.1 1794981 1795052 R tRNA-Glu complement(1794981..1795052) Streptococcus pneumoniae R6 933574 sprt43 tRNA tRNA-Leu6 NC_003098.1 1850742 1850825 R tRNA-Leu complement(1850742..1850825) Streptococcus pneumoniae R6 934000 sprt44 tRNA tRNA-Gln2 NC_003098.1 1850835 1850906 R tRNA-Gln complement(1850835..1850906) Streptococcus pneumoniae R6 934002 sprt45 tRNA tRNA-His NC_003098.1 1850917 1850989 R tRNA-His complement(1850917..1850989) Streptococcus pneumoniae R6 934007 sprt46 tRNA tRNA-Trp NC_003098.1 1851004 1851074 R tRNA-Trp complement(1851004..1851074) Streptococcus pneumoniae R6 934005 sprt47 tRNA tRNA-Tyr2 NC_003098.1 1851079 1851159 R tRNA-Tyr complement(1851079..1851159) Streptococcus pneumoniae R6 934006 sprt48 tRNA tRNA-Phe2 NC_003098.1 1851172 1851244 R tRNA-Phe complement(1851172..1851244) Streptococcus pneumoniae R6 934010 sprt49 tRNA tRNA-Met4 NC_003098.1 1851248 1851321 R tRNA-Met complement(1851248..1851321) Streptococcus pneumoniae R6 934008 sprt50 tRNA tRNA-Ser4 NC_003098.1 1851332 1851421 R tRNA-Ser complement(1851332..1851421) Streptococcus pneumoniae R6 934009 sprt51 tRNA tRNA-Ile2 NC_003098.1 1851505 1851578 R tRNA-Ile complement(1851505..1851578) Streptococcus pneumoniae R6 934013 sprt52 tRNA tRNA-Gly4 NC_003098.1 1851613 1851683 R tRNA-Gly complement(1851613..1851683) Streptococcus pneumoniae R6 934011 sprt53 tRNA tRNA-Val3 NC_003098.1 1851689 1851761 R tRNA-Val complement(1851689..1851761) Streptococcus pneumoniae R6 934012 sprt54 tRNA tRNA-Ala4 NC_003098.1 1854984 1855056 R tRNA-Ala complement(1854984..1855056) Streptococcus pneumoniae R6 934015 sprt55 tRNA tRNA-Glu4 NC_003098.1 1856906 1856977 R tRNA-Glu complement(1856906..1856977) Streptococcus pneumoniae R6 934017 sprt56 tRNA tRNA-Asn2 NC_003098.1 2033040 2033113 R tRNA-Asn complement(2033040..2033113) Streptococcus pneumoniae R6 934869 sprt57 tRNA tRNA-Glu5 NC_003098.1 2033119 2033190 R tRNA-Glu complement(2033119..2033190) Streptococcus pneumoniae R6 933494 sprt58 tRNA tRNA-Arg5 NC_003098.1 2035627 2035700 R tRNA-Arg complement(2035627..2035700) Streptococcus pneumoniae R6 933734 sprr01 rRNA rRNA_16S-1 NC_003098.1 15161 16674 D 16S ribosomal RNA 15161..16674 Streptococcus pneumoniae R6 933447 sprr02 rRNA rRNA_23S-1 NC_003098.1 16945 19846 D 23S ribosomal RNA 16945..19846 Streptococcus pneumoniae R6 934056 sprr03 rRNA rRNA_5S-1 NC_003098.1 19924 20038 D 5S ribosomal RNA 19924..20038 Streptococcus pneumoniae R6 933458 sprr04 rRNA rRNA_5S-2 NC_003098.1 1692291 1692405 R 5S ribosomal RNA complement(1692291..1692405) Streptococcus pneumoniae R6 933193 sprr05 rRNA rRNA_23S-2 NC_003098.1 1692483 1695384 R 23S ribosomal RNA complement(1692483..1695384) Streptococcus pneumoniae R6 933702 sprr06 rRNA rRNA_16S-2 NC_003098.1 1695655 1697168 R 16S ribosomal RNA complement(1695655..1697168) Streptococcus pneumoniae R6 933007 sprr07 rRNA rRNA_5S-3 NC_003098.1 1789841 1789955 R 5S ribosomal RNA complement(1789841..1789955) Streptococcus pneumoniae R6 933575 sprr08 rRNA rRNA_23S-3 NC_003098.1 1790033 1792934 R 23S ribosomal RNA complement(1790033..1792934) Streptococcus pneumoniae R6 933578 sprr09 rRNA rRNA_16S-3 NC_003098.1 1793205 1794718 R 16S ribosomal RNA complement(1793205..1794718) Streptococcus pneumoniae R6 933571 sprr10 rRNA rRNA_5S-4 NC_003098.1 1851766 1851880 R 5S ribosomal RNA complement(1851766..1851880) Streptococcus pneumoniae R6 934016 sprr11 rRNA rRNA_23S-4 NC_003098.1 1851958 1854859 R 23S ribosomal RNA complement(1851958..1854859) Streptococcus pneumoniae R6 934014 sprr12 rRNA rRNA_16S-4 NC_003098.1 1855130 1856643 R 16S ribosomal RNA complement(1855130..1856643) Streptococcus pneumoniae R6 934020