-- dump date 20140620_085218 -- class Genbank::misc_feature -- table misc_feature_note -- id note 869309000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 869309000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309000003 Walker A motif; other site 869309000004 ATP binding site [chemical binding]; other site 869309000005 Walker B motif; other site 869309000006 arginine finger; other site 869309000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 869309000008 DnaA box-binding interface [nucleotide binding]; other site 869309000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 869309000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 869309000011 putative DNA binding surface [nucleotide binding]; other site 869309000012 dimer interface [polypeptide binding]; other site 869309000013 beta-clamp/clamp loader binding surface; other site 869309000014 beta-clamp/translesion DNA polymerase binding surface; other site 869309000015 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 869309000016 GTP-binding protein YchF; Reviewed; Region: PRK09601 869309000017 YchF GTPase; Region: YchF; cd01900 869309000018 G1 box; other site 869309000019 GTP/Mg2+ binding site [chemical binding]; other site 869309000020 Switch I region; other site 869309000021 G2 box; other site 869309000022 Switch II region; other site 869309000023 G3 box; other site 869309000024 G4 box; other site 869309000025 G5 box; other site 869309000026 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 869309000027 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 869309000028 putative active site [active] 869309000029 catalytic residue [active] 869309000030 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 869309000031 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 869309000032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869309000033 ATP binding site [chemical binding]; other site 869309000034 putative Mg++ binding site [ion binding]; other site 869309000035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869309000036 nucleotide binding region [chemical binding]; other site 869309000037 ATP-binding site [chemical binding]; other site 869309000038 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 869309000039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869309000040 RNA binding surface [nucleotide binding]; other site 869309000041 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 869309000042 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 869309000043 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 869309000044 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 869309000045 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 869309000046 Ligand Binding Site [chemical binding]; other site 869309000047 TilS substrate C-terminal domain; Region: TilS_C; smart00977 869309000048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869309000049 active site 869309000050 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 869309000051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309000052 Walker A motif; other site 869309000053 ATP binding site [chemical binding]; other site 869309000054 Walker B motif; other site 869309000055 arginine finger; other site 869309000056 Peptidase family M41; Region: Peptidase_M41; pfam01434 869309000059 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 869309000060 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 869309000061 GDP-binding site [chemical binding]; other site 869309000062 ACT binding site; other site 869309000063 IMP binding site; other site 869309000064 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 869309000065 active site 869309000066 catalytic residues [active] 869309000067 DNA binding site [nucleotide binding] 869309000068 Int/Topo IB signature motif; other site 869309000069 Uncharacterized conserved protein [Function unknown]; Region: COG4127 869309000070 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869309000071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309000072 non-specific DNA binding site [nucleotide binding]; other site 869309000073 salt bridge; other site 869309000074 sequence-specific DNA binding site [nucleotide binding]; other site 869309000075 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 869309000076 Prophage antirepressor [Transcription]; Region: COG3617 869309000077 BRO family, N-terminal domain; Region: Bro-N; smart01040 869309000078 ORF6C domain; Region: ORF6C; pfam10552 869309000079 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 869309000080 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 869309000081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309000082 Walker A motif; other site 869309000083 ATP binding site [chemical binding]; other site 869309000084 Walker B motif; other site 869309000085 arginine finger; other site 869309000086 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 869309000087 Int/Topo IB signature motif; other site 869309000088 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 869309000089 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869309000090 ATP binding site [chemical binding]; other site 869309000091 putative Mg++ binding site [ion binding]; other site 869309000092 Phage-related protein [Function unknown]; Region: COG4695; cl01923 869309000093 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 869309000094 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 869309000096 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 869309000097 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 869309000098 Phage-related minor tail protein [Function unknown]; Region: COG5280 869309000099 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 869309000100 membrane protein P6; Region: PHA01399 869309000101 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 869309000102 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 869309000103 toxin secretion/phage lysis holin; Region: holin_tox_secr; TIGR01593 869309000104 Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682 869309000105 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869309000106 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 869309000107 amidase catalytic site [active] 869309000108 Zn binding residues [ion binding]; other site 869309000109 substrate binding site [chemical binding]; other site 869309000111 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 869309000112 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 869309000113 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869309000114 Calx-beta domain; Region: Calx-beta; cl02522 869309000115 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 869309000116 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 869309000117 Uncharacterized conserved protein [Function unknown]; Region: COG3538 869309000118 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 869309000119 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 869309000120 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 869309000121 active site 869309000122 metal binding site [ion binding]; metal-binding site 869309000123 homodimer interface [polypeptide binding]; other site 869309000124 catalytic site [active] 869309000125 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 869309000126 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869309000127 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869309000128 nucleotide binding site [chemical binding]; other site 869309000129 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 869309000130 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 869309000131 putative active site [active] 869309000133 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 869309000134 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869309000135 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309000136 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309000137 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309000138 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309000139 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309000140 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309000141 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309000142 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 869309000143 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 869309000144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 869309000145 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 869309000146 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 869309000147 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869309000148 PRD domain; Region: PRD; pfam00874 869309000149 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869309000150 active site 869309000151 P-loop; other site 869309000152 phosphorylation site [posttranslational modification] 869309000153 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869309000154 active site 869309000155 phosphorylation site [posttranslational modification] 869309000156 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 869309000157 active site 869309000158 P-loop; other site 869309000159 phosphorylation site [posttranslational modification] 869309000160 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 869309000161 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869309000162 TPP-binding site [chemical binding]; other site 869309000163 dimer interface [polypeptide binding]; other site 869309000164 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 869309000165 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869309000166 PYR/PP interface [polypeptide binding]; other site 869309000167 dimer interface [polypeptide binding]; other site 869309000168 TPP binding site [chemical binding]; other site 869309000169 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869309000170 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 869309000171 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 869309000172 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309000173 non-specific DNA binding site [nucleotide binding]; other site 869309000174 salt bridge; other site 869309000175 sequence-specific DNA binding site [nucleotide binding]; other site 869309000176 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869309000177 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 869309000178 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 869309000179 dimer interface [polypeptide binding]; other site 869309000180 motif 1; other site 869309000181 active site 869309000182 motif 2; other site 869309000183 motif 3; other site 869309000184 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 869309000185 anticodon binding site; other site 869309000186 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309000187 non-specific DNA binding site [nucleotide binding]; other site 869309000188 salt bridge; other site 869309000189 sequence-specific DNA binding site [nucleotide binding]; other site 869309000190 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 869309000191 CAAX protease self-immunity; Region: Abi; pfam02517 869309000192 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 869309000193 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 869309000194 dimer interface [polypeptide binding]; other site 869309000195 anticodon binding site; other site 869309000196 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869309000197 homodimer interface [polypeptide binding]; other site 869309000198 motif 1; other site 869309000199 active site 869309000200 motif 2; other site 869309000201 GAD domain; Region: GAD; pfam02938 869309000202 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 869309000203 motif 3; other site 869309000204 Uncharacterized conserved protein [Function unknown]; Region: COG1284 869309000205 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869309000206 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869309000207 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 869309000208 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869309000209 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869309000210 DNA binding site [nucleotide binding] 869309000211 domain linker motif; other site 869309000212 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 869309000213 putative dimerization interface [polypeptide binding]; other site 869309000214 putative ligand binding site [chemical binding]; other site 869309000215 Predicted integral membrane protein [Function unknown]; Region: COG5521 869309000216 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869309000217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309000218 dimer interface [polypeptide binding]; other site 869309000219 conserved gate region; other site 869309000220 putative PBP binding loops; other site 869309000221 ABC-ATPase subunit interface; other site 869309000222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309000223 dimer interface [polypeptide binding]; other site 869309000224 conserved gate region; other site 869309000225 putative PBP binding loops; other site 869309000226 ABC-ATPase subunit interface; other site 869309000227 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 869309000228 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869309000229 4-alpha-glucanotransferase; Provisional; Region: PRK14508 869309000230 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 869309000231 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 869309000232 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 869309000233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309000234 S-adenosylmethionine binding site [chemical binding]; other site 869309000235 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 869309000236 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869309000237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309000238 motif II; other site 869309000240 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 869309000241 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 869309000242 active site 869309000243 HIGH motif; other site 869309000244 dimer interface [polypeptide binding]; other site 869309000245 KMSKS motif; other site 869309000246 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869309000247 RNA binding surface [nucleotide binding]; other site 869309000248 Transglycosylase; Region: Transgly; pfam00912 869309000249 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 869309000250 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869309000251 EamA-like transporter family; Region: EamA; pfam00892 869309000252 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 869309000253 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 869309000254 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 869309000255 trimer interface [polypeptide binding]; other site 869309000256 active site 869309000257 substrate binding site [chemical binding]; other site 869309000258 CoA binding site [chemical binding]; other site 869309000259 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 869309000260 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 869309000261 metal binding site [ion binding]; metal-binding site 869309000262 putative dimer interface [polypeptide binding]; other site 869309000263 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 869309000264 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 869309000265 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 869309000266 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 869309000267 metal binding site [ion binding]; metal-binding site 869309000268 putative dimer interface [polypeptide binding]; other site 869309000269 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 869309000270 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 869309000271 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 869309000272 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 869309000273 active site 869309000274 tetramer interface; other site 869309000275 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 869309000276 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 869309000277 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 869309000279 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 869309000280 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 869309000281 PhoU domain; Region: PhoU; pfam01895 869309000282 PhoU domain; Region: PhoU; pfam01895 869309000283 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 869309000284 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869309000285 Walker A/P-loop; other site 869309000286 ATP binding site [chemical binding]; other site 869309000287 Q-loop/lid; other site 869309000288 ABC transporter signature motif; other site 869309000289 Walker B; other site 869309000290 D-loop; other site 869309000291 H-loop/switch region; other site 869309000292 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 869309000293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309000294 dimer interface [polypeptide binding]; other site 869309000295 conserved gate region; other site 869309000296 putative PBP binding loops; other site 869309000297 ABC-ATPase subunit interface; other site 869309000298 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 869309000299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309000300 dimer interface [polypeptide binding]; other site 869309000301 conserved gate region; other site 869309000302 putative PBP binding loops; other site 869309000303 ABC-ATPase subunit interface; other site 869309000304 PBP superfamily domain; Region: PBP_like_2; cl17296 869309000305 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 869309000306 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 869309000307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869309000308 dimer interface [polypeptide binding]; other site 869309000309 phosphorylation site [posttranslational modification] 869309000310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869309000311 ATP binding site [chemical binding]; other site 869309000312 G-X-G motif; other site 869309000313 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869309000314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309000315 active site 869309000316 phosphorylation site [posttranslational modification] 869309000317 intermolecular recognition site; other site 869309000318 dimerization interface [polypeptide binding]; other site 869309000319 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869309000320 DNA binding site [nucleotide binding] 869309000321 Uncharacterized conserved protein [Function unknown]; Region: COG3542 869309000323 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 869309000324 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 869309000325 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 869309000326 active site 869309000327 HIGH motif; other site 869309000328 KMSK motif region; other site 869309000329 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 869309000330 tRNA binding surface [nucleotide binding]; other site 869309000331 anticodon binding site; other site 869309000332 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869309000333 arginine repressor; Region: argR_whole; TIGR01529 869309000334 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869309000335 DNA mismatch repair protein MutS; Region: mutS1; TIGR01070 869309000336 MutS domain I; Region: MutS_I; pfam01624 869309000337 MutS domain II; Region: MutS_II; pfam05188 869309000338 MutS domain III; Region: MutS_III; pfam05192 869309000339 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 869309000340 Walker A/P-loop; other site 869309000341 ATP binding site [chemical binding]; other site 869309000342 Q-loop/lid; other site 869309000343 ABC transporter signature motif; other site 869309000344 Walker B; other site 869309000345 D-loop; other site 869309000346 H-loop/switch region; other site 869309000347 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869309000348 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869309000349 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309000350 Walker A/P-loop; other site 869309000351 ATP binding site [chemical binding]; other site 869309000352 Q-loop/lid; other site 869309000353 ABC transporter signature motif; other site 869309000354 Walker B; other site 869309000355 D-loop; other site 869309000356 H-loop/switch region; other site 869309000357 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869309000358 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869309000359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309000360 Walker A/P-loop; other site 869309000361 ATP binding site [chemical binding]; other site 869309000362 Q-loop/lid; other site 869309000363 ABC transporter signature motif; other site 869309000364 Walker B; other site 869309000365 D-loop; other site 869309000366 H-loop/switch region; other site 869309000367 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 869309000368 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 869309000369 catalytic triad [active] 869309000370 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 869309000371 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 869309000372 active site 869309000373 dimer interface [polypeptide binding]; other site 869309000374 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 869309000375 dimer interface [polypeptide binding]; other site 869309000376 active site 869309000377 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 869309000378 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869309000379 active site 869309000380 HIGH motif; other site 869309000381 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 869309000382 active site 869309000383 KMSKS motif; other site 869309000384 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 869309000385 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 869309000386 active site 869309000387 catalytic motif [active] 869309000388 Zn binding site [ion binding]; other site 869309000389 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869309000390 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 869309000391 active site 869309000392 metal binding site [ion binding]; metal-binding site 869309000393 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 869309000394 HD domain; Region: HD_4; pfam13328 869309000395 integrase; Provisional; Region: int; PHA02601 869309000396 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 869309000397 Int/Topo IB signature motif; other site 869309000398 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 869309000399 putative replication initiation protein; Region: PHA00330 869309000400 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869309000401 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 869309000402 active site 869309000403 metal binding site [ion binding]; metal-binding site 869309000405 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 869309000406 putative catalytic site [active] 869309000407 putative metal binding site [ion binding]; other site 869309000408 putative phosphate binding site [ion binding]; other site 869309000409 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 869309000410 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 869309000411 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 869309000412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869309000413 catalytic residue [active] 869309000414 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 869309000415 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 869309000417 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869309000419 Predicted membrane protein [Function unknown]; Region: COG3759 869309000421 Predicted integral membrane protein [Function unknown]; Region: COG5523 869309000422 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 869309000423 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 869309000424 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 869309000425 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 869309000426 catalytic triad [active] 869309000427 catalytic triad [active] 869309000428 oxyanion hole [active] 869309000429 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 869309000430 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 869309000431 active site 869309000432 dimer interface [polypeptide binding]; other site 869309000433 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 869309000434 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869309000435 catalytic Zn binding site [ion binding]; other site 869309000436 structural Zn binding site [ion binding]; other site 869309000437 NAD(P) binding site [chemical binding]; other site 869309000438 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 869309000439 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 869309000440 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869309000441 Walker A motif; other site 869309000442 ATP binding site [chemical binding]; other site 869309000443 Walker B motif; other site 869309000444 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 869309000445 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 869309000446 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 869309000447 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 869309000448 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 869309000449 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 869309000450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869309000451 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869309000452 Coenzyme A binding pocket [chemical binding]; other site 869309000454 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 869309000455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309000456 S-adenosylmethionine binding site [chemical binding]; other site 869309000457 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 869309000458 propionate/acetate kinase; Provisional; Region: PRK12379 869309000459 ribonuclease P; Reviewed; Region: rnpA; PRK00499 869309000460 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 869309000461 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 869309000462 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 869309000463 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 869309000464 G-X-X-G motif; other site 869309000465 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 869309000466 RxxxH motif; other site 869309000467 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 869309000468 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 869309000469 active site 869309000470 P-loop; other site 869309000471 phosphorylation site [posttranslational modification] 869309000472 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869309000473 active site 869309000474 phosphorylation site [posttranslational modification] 869309000475 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 869309000476 active site 869309000477 dimer interface [polypeptide binding]; other site 869309000478 magnesium binding site [ion binding]; other site 869309000479 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 869309000480 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 869309000481 AP (apurinic/apyrimidinic) site pocket; other site 869309000482 DNA interaction; other site 869309000483 Metal-binding active site; metal-binding site 869309000484 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 869309000485 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 869309000486 intersubunit interface [polypeptide binding]; other site 869309000487 active site 869309000488 Zn2+ binding site [ion binding]; other site 869309000489 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869309000490 PRD domain; Region: PRD; pfam00874 869309000491 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869309000492 active site 869309000493 P-loop; other site 869309000494 phosphorylation site [posttranslational modification] 869309000495 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 869309000496 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 869309000497 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 869309000498 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 869309000499 TPP-binding site [chemical binding]; other site 869309000500 dimer interface [polypeptide binding]; other site 869309000501 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869309000502 PYR/PP interface [polypeptide binding]; other site 869309000503 dimer interface [polypeptide binding]; other site 869309000504 TPP binding site [chemical binding]; other site 869309000505 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869309000506 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 869309000507 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 869309000508 Low molecular weight phosphatase family; Region: LMWPc; cd00115 869309000509 active site 869309000510 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 869309000511 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 869309000512 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 869309000513 putative catalytic cysteine [active] 869309000514 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 869309000515 putative active site [active] 869309000516 metal binding site [ion binding]; metal-binding site 869309000517 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869309000518 methionine cluster; other site 869309000519 active site 869309000520 phosphorylation site [posttranslational modification] 869309000521 metal binding site [ion binding]; metal-binding site 869309000522 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 869309000523 active site 869309000524 P-loop; other site 869309000525 phosphorylation site [posttranslational modification] 869309000526 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869309000527 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 869309000528 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 869309000529 beta-galactosidase; Region: BGL; TIGR03356 869309000530 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869309000531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869309000532 DNA-binding site [nucleotide binding]; DNA binding site 869309000533 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 869309000534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 869309000535 Walker A/P-loop; other site 869309000536 ATP binding site [chemical binding]; other site 869309000537 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 869309000538 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 869309000539 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559 869309000540 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 869309000541 dimerization interface [polypeptide binding]; other site 869309000542 active site 869309000544 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 869309000545 FtsX-like permease family; Region: FtsX; pfam02687 869309000546 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 869309000547 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 869309000548 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 869309000549 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869309000550 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869309000551 active site 869309000552 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 869309000553 Transglycosylase; Region: Transgly; pfam00912 869309000554 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869309000555 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 869309000556 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 869309000557 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 869309000558 putative homodimer interface [polypeptide binding]; other site 869309000559 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 869309000560 heterodimer interface [polypeptide binding]; other site 869309000561 homodimer interface [polypeptide binding]; other site 869309000562 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 869309000564 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 869309000565 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869309000566 Walker A/P-loop; other site 869309000567 ATP binding site [chemical binding]; other site 869309000568 Q-loop/lid; other site 869309000569 ABC transporter signature motif; other site 869309000570 Walker B; other site 869309000571 D-loop; other site 869309000572 H-loop/switch region; other site 869309000573 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 869309000574 ABC-2 type transporter; Region: ABC2_membrane; cl17235 869309000575 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 869309000576 Histidine kinase; Region: HisKA_3; pfam07730 869309000577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869309000578 ATP binding site [chemical binding]; other site 869309000579 Mg2+ binding site [ion binding]; other site 869309000580 G-X-G motif; other site 869309000581 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869309000582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309000583 active site 869309000584 phosphorylation site [posttranslational modification] 869309000585 intermolecular recognition site; other site 869309000586 dimerization interface [polypeptide binding]; other site 869309000587 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869309000588 DNA binding residues [nucleotide binding] 869309000589 dimerization interface [polypeptide binding]; other site 869309000590 catabolite control protein A; Region: ccpA; TIGR01481 869309000591 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869309000592 DNA binding site [nucleotide binding] 869309000593 domain linker motif; other site 869309000594 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 869309000595 dimerization interface [polypeptide binding]; other site 869309000596 effector binding site; other site 869309000597 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 869309000598 active site 869309000599 homotetramer interface [polypeptide binding]; other site 869309000600 homodimer interface [polypeptide binding]; other site 869309000601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309000602 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869309000603 active site 869309000604 motif I; other site 869309000605 motif II; other site 869309000606 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309000607 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 869309000608 putative nucleotide binding site [chemical binding]; other site 869309000609 putative metal binding site [ion binding]; other site 869309000610 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 869309000611 Ligand Binding Site [chemical binding]; other site 869309000612 aminotransferase AlaT; Validated; Region: PRK09265 869309000613 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869309000614 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869309000615 homodimer interface [polypeptide binding]; other site 869309000616 catalytic residue [active] 869309000617 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 869309000618 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 869309000619 active site 869309000620 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 869309000621 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 869309000622 putative active site [active] 869309000623 putative metal binding site [ion binding]; other site 869309000624 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 869309000625 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869309000626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309000627 non-specific DNA binding site [nucleotide binding]; other site 869309000628 salt bridge; other site 869309000629 sequence-specific DNA binding site [nucleotide binding]; other site 869309000630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 869309000631 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 869309000632 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869309000633 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869309000634 Walker A/P-loop; other site 869309000635 ATP binding site [chemical binding]; other site 869309000636 Q-loop/lid; other site 869309000637 ABC transporter signature motif; other site 869309000638 Walker B; other site 869309000639 D-loop; other site 869309000640 H-loop/switch region; other site 869309000641 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 869309000642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309000643 S-adenosylmethionine binding site [chemical binding]; other site 869309000645 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 869309000646 Thiamine pyrophosphokinase; Region: TPK; cd07995 869309000647 active site 869309000648 dimerization interface [polypeptide binding]; other site 869309000649 thiamine binding site [chemical binding]; other site 869309000650 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 869309000651 RmuC family; Region: RmuC; pfam02646 869309000652 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 869309000653 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 869309000654 generic binding surface II; other site 869309000655 generic binding surface I; other site 869309000656 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869309000657 Zn2+ binding site [ion binding]; other site 869309000658 Mg2+ binding site [ion binding]; other site 869309000659 pur operon repressor; Provisional; Region: PRK09213 869309000660 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 869309000661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869309000662 active site 869309000663 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 869309000664 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 869309000665 active site 869309000666 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869309000667 substrate binding site [chemical binding]; other site 869309000668 catalytic residues [active] 869309000669 dimer interface [polypeptide binding]; other site 869309000670 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 869309000671 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869309000672 FeS/SAM binding site; other site 869309000673 OxaA-like protein precursor; Provisional; Region: PRK02463 869309000674 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 869309000675 acylphosphatase; Provisional; Region: PRK14434 869309000676 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 869309000677 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 869309000678 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869309000679 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 869309000680 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 869309000681 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 869309000682 dimer interface [polypeptide binding]; other site 869309000683 active site 869309000684 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 869309000685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309000686 S-adenosylmethionine binding site [chemical binding]; other site 869309000687 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 869309000688 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 869309000689 active site 869309000690 (T/H)XGH motif; other site 869309000691 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 869309000692 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 869309000693 protein binding site [polypeptide binding]; other site 869309000694 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 869309000695 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 869309000696 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 869309000697 hinge; other site 869309000698 active site 869309000699 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 869309000700 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 869309000701 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 869309000702 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 869309000703 Domain of unknown function DUF21; Region: DUF21; pfam01595 869309000704 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 869309000705 Transporter associated domain; Region: CorC_HlyC; smart01091 869309000706 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 869309000707 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 869309000708 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 869309000709 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 869309000710 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 869309000711 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 869309000712 RPB1 interaction site [polypeptide binding]; other site 869309000713 RPB10 interaction site [polypeptide binding]; other site 869309000714 RPB11 interaction site [polypeptide binding]; other site 869309000715 RPB3 interaction site [polypeptide binding]; other site 869309000716 RPB12 interaction site [polypeptide binding]; other site 869309000717 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 869309000718 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 869309000719 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 869309000720 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 869309000721 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 869309000722 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 869309000723 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 869309000724 G-loop; other site 869309000725 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 869309000726 DNA binding site [nucleotide binding] 869309000727 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 869309000728 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 869309000729 active site 869309000730 multimer interface [polypeptide binding]; other site 869309000732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309000733 Q-loop/lid; other site 869309000734 ABC transporter signature motif; other site 869309000735 Walker B; other site 869309000736 D-loop; other site 869309000737 H-loop/switch region; other site 869309000738 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869309000740 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 869309000741 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869309000742 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869309000743 Coenzyme A binding pocket [chemical binding]; other site 869309000744 Transcriptional regulator [Transcription]; Region: LytR; COG1316 869309000745 competence damage-inducible protein A; Provisional; Region: PRK00549 869309000746 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 869309000747 putative MPT binding site; other site 869309000748 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 869309000749 recombinase A; Provisional; Region: recA; PRK09354 869309000750 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 869309000751 hexamer interface [polypeptide binding]; other site 869309000752 Walker A motif; other site 869309000753 ATP binding site [chemical binding]; other site 869309000754 Walker B motif; other site 869309000755 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 869309000756 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 869309000757 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869309000758 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 869309000759 substrate binding site [chemical binding]; other site 869309000760 amidase catalytic site [active] 869309000761 Zn binding residues [ion binding]; other site 869309000762 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 869309000764 hypothetical protein; Provisional; Region: PRK12378 869309000766 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869309000767 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869309000768 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869309000769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309000770 Walker A/P-loop; other site 869309000771 ATP binding site [chemical binding]; other site 869309000772 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 869309000773 Walker A/P-loop; other site 869309000774 ATP binding site [chemical binding]; other site 869309000775 Q-loop/lid; other site 869309000776 ABC transporter signature motif; other site 869309000777 Walker B; other site 869309000778 D-loop; other site 869309000779 H-loop/switch region; other site 869309000780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4898 869309000781 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 869309000782 active site 869309000783 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869309000784 LytTr DNA-binding domain; Region: LytTR; pfam04397 869309000785 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869309000786 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869309000787 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869309000788 catalytic residues [active] 869309000789 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 869309000790 putative tRNA-binding site [nucleotide binding]; other site 869309000791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869309000792 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 869309000793 NAD(P) binding site [chemical binding]; other site 869309000794 active site 869309000795 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 869309000796 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 869309000797 Presynaptic Site I dimer interface [polypeptide binding]; other site 869309000798 catalytic residues [active] 869309000799 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 869309000800 Synaptic Flat tetramer interface [polypeptide binding]; other site 869309000801 Synaptic Site I dimer interface [polypeptide binding]; other site 869309000802 DNA binding site [nucleotide binding] 869309000803 Recombinase; Region: Recombinase; pfam07508 869309000804 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 869309000805 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869309000806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309000807 non-specific DNA binding site [nucleotide binding]; other site 869309000808 salt bridge; other site 869309000809 sequence-specific DNA binding site [nucleotide binding]; other site 869309000810 Predicted transcriptional regulator [Transcription]; Region: COG2932 869309000811 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 869309000812 Catalytic site [active] 869309000813 Helix-turn-helix domain; Region: HTH_36; pfam13730 869309000814 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 869309000815 ParB-like nuclease domain; Region: ParB; smart00470 869309000816 NLE (NUC135) domain; Region: NLE; pfam08154 869309000817 RecT family; Region: RecT; pfam03837 869309000818 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 869309000819 DNA gyrase subunit A; Validated; Region: PRK05560 869309000820 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869309000821 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869309000822 dimer interface [polypeptide binding]; other site 869309000823 ssDNA binding site [nucleotide binding]; other site 869309000824 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869309000825 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 869309000826 YopX protein; Region: YopX; cl09859 869309000827 PemK-like protein; Region: PemK; pfam02452 869309000828 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 869309000829 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 869309000830 Terminase small subunit; Region: Terminase_2; pfam03592 869309000831 Phage terminase large subunit; Region: Terminase_3; cl12054 869309000832 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 869309000833 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 869309000834 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 869309000835 HD domain; Region: HD_4; pfam13328 869309000836 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 869309000837 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 869309000838 aromatic chitin/cellulose binding site residues [chemical binding]; other site 869309000839 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 869309000840 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 869309000841 Phage tail protein; Region: Phage_tail_3; pfam08813 869309000842 2-hydroxymuconic semialdehyde dehydrogenase; Region: OH_muco_semi_DH; TIGR03216 869309000843 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 869309000844 Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682 869309000845 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869309000846 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 869309000847 amidase catalytic site [active] 869309000848 Zn binding residues [ion binding]; other site 869309000849 substrate binding site [chemical binding]; other site 869309000850 hydrolase; Region: PLN02578 869309000852 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 869309000853 oligomerisation interface [polypeptide binding]; other site 869309000854 mobile loop; other site 869309000855 roof hairpin; other site 869309000856 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 869309000857 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 869309000858 ring oligomerisation interface [polypeptide binding]; other site 869309000859 ATP/Mg binding site [chemical binding]; other site 869309000860 stacking interactions; other site 869309000861 hinge regions; other site 869309000863 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869309000864 hypothetical protein; Provisional; Region: PRK13662 869309000865 recombination regulator RecX; Provisional; Region: recX; PRK14135 869309000866 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 869309000867 active site 869309000868 Phosphotransferase enzyme family; Region: APH; pfam01636 869309000869 ATP binding site [chemical binding]; other site 869309000870 antibiotic binding site [chemical binding]; other site 869309000871 TRAM domain; Region: TRAM; pfam01938 869309000872 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 869309000873 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309000874 S-adenosylmethionine binding site [chemical binding]; other site 869309000876 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 869309000877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869309000878 DNA-binding site [nucleotide binding]; DNA binding site 869309000879 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 869309000880 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 869309000881 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 869309000882 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869309000883 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869309000884 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869309000885 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 869309000886 Melibiase; Region: Melibiase; pfam02065 869309000887 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869309000888 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869309000889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309000890 dimer interface [polypeptide binding]; other site 869309000891 conserved gate region; other site 869309000892 putative PBP binding loops; other site 869309000893 ABC-ATPase subunit interface; other site 869309000895 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 869309000896 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 869309000897 active site 869309000898 homodimer interface [polypeptide binding]; other site 869309000899 catalytic site [active] 869309000900 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 869309000901 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 869309000902 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 869309000903 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869309000904 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869309000905 peptide binding site [polypeptide binding]; other site 869309000906 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 869309000907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309000908 dimer interface [polypeptide binding]; other site 869309000909 conserved gate region; other site 869309000910 putative PBP binding loops; other site 869309000911 ABC-ATPase subunit interface; other site 869309000912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 869309000913 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 869309000914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309000915 dimer interface [polypeptide binding]; other site 869309000916 conserved gate region; other site 869309000917 putative PBP binding loops; other site 869309000918 ABC-ATPase subunit interface; other site 869309000919 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 869309000920 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869309000921 Walker A/P-loop; other site 869309000922 ATP binding site [chemical binding]; other site 869309000923 Q-loop/lid; other site 869309000924 ABC transporter signature motif; other site 869309000925 Walker B; other site 869309000926 D-loop; other site 869309000927 H-loop/switch region; other site 869309000928 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 869309000929 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 869309000930 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 869309000931 Walker A/P-loop; other site 869309000932 ATP binding site [chemical binding]; other site 869309000933 Q-loop/lid; other site 869309000934 ABC transporter signature motif; other site 869309000935 Walker B; other site 869309000936 D-loop; other site 869309000937 H-loop/switch region; other site 869309000938 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 869309000939 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 869309000940 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 869309000941 zinc binding site [ion binding]; other site 869309000942 putative ligand binding site [chemical binding]; other site 869309000945 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869309000946 DNA-binding site [nucleotide binding]; DNA binding site 869309000947 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 869309000948 UTRA domain; Region: UTRA; pfam07702 869309000949 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 869309000950 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869309000951 active site turn [active] 869309000952 phosphorylation site [posttranslational modification] 869309000953 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869309000954 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 869309000955 HPr interaction site; other site 869309000956 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869309000957 active site 869309000958 phosphorylation site [posttranslational modification] 869309000959 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 869309000960 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 869309000961 Ca binding site [ion binding]; other site 869309000962 active site 869309000963 catalytic site [active] 869309000964 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 869309000965 glutamate racemase; Provisional; Region: PRK00865 869309000966 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 869309000967 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 869309000968 active site 869309000969 dimerization interface [polypeptide binding]; other site 869309000970 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 869309000971 active site 869309000972 metal binding site [ion binding]; metal-binding site 869309000973 homotetramer interface [polypeptide binding]; other site 869309000974 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 869309000975 FOG: CBS domain [General function prediction only]; Region: COG0517 869309000976 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 869309000977 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 869309000978 DNA binding site [nucleotide binding] 869309000979 Int/Topo IB signature motif; other site 869309000980 active site 869309000981 catalytic residues [active] 869309000982 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 869309000983 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 869309000984 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869309000985 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869309000986 RNA binding surface [nucleotide binding]; other site 869309000987 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 869309000988 active site 869309000989 hypothetical protein; Validated; Region: PRK00041 869309000990 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 869309000991 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 869309000992 putative ligand binding residues [chemical binding]; other site 869309000993 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869309000994 ABC transporter; Region: ABC_tran; pfam00005 869309000995 Q-loop/lid; other site 869309000996 ABC transporter signature motif; other site 869309000997 Walker B; other site 869309000998 D-loop; other site 869309000999 H-loop/switch region; other site 869309001000 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869309001001 ABC-ATPase subunit interface; other site 869309001002 dimer interface [polypeptide binding]; other site 869309001003 putative PBP binding regions; other site 869309001004 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869309001005 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869309001006 ABC-ATPase subunit interface; other site 869309001007 dimer interface [polypeptide binding]; other site 869309001008 putative PBP binding regions; other site 869309001009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869309001010 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 869309001011 NAD(P) binding site [chemical binding]; other site 869309001012 active site 869309001013 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 869309001014 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 869309001015 oligomer interface [polypeptide binding]; other site 869309001016 active site 869309001017 metal binding site [ion binding]; metal-binding site 869309001018 Enterocin A Immunity; Region: EntA_Immun; pfam08951 869309001019 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869309001020 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 869309001021 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 869309001022 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869309001023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309001024 Walker A/P-loop; other site 869309001025 ATP binding site [chemical binding]; other site 869309001026 Q-loop/lid; other site 869309001027 ABC transporter signature motif; other site 869309001028 Walker B; other site 869309001029 D-loop; other site 869309001030 H-loop/switch region; other site 869309001031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309001032 dimer interface [polypeptide binding]; other site 869309001033 conserved gate region; other site 869309001034 ABC-ATPase subunit interface; other site 869309001035 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 869309001036 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 869309001037 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 869309001038 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869309001039 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869309001040 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 869309001041 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 869309001042 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 869309001043 DNA binding residues [nucleotide binding] 869309001044 putative dimer interface [polypeptide binding]; other site 869309001046 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 869309001047 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869309001048 DNA binding site [nucleotide binding] 869309001049 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 869309001050 putative dimerization interface [polypeptide binding]; other site 869309001051 putative ligand binding site [chemical binding]; other site 869309001052 galactokinase; Provisional; Region: PRK05322 869309001053 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 869309001054 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869309001055 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869309001056 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 869309001057 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 869309001058 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 869309001059 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 869309001060 CoenzymeA binding site [chemical binding]; other site 869309001061 subunit interaction site [polypeptide binding]; other site 869309001062 PHB binding site; other site 869309001063 Dam-replacing family; Region: DRP; pfam06044 869309001064 DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207 869309001065 xanthine permease; Region: pbuX; TIGR03173 869309001066 Sulfate transporter family; Region: Sulfate_transp; pfam00916 869309001067 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869309001068 active site 869309001069 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 869309001070 active site 869309001071 putative catalytic site [active] 869309001072 DNA binding site [nucleotide binding] 869309001073 putative phosphate binding site [ion binding]; other site 869309001074 metal binding site A [ion binding]; metal-binding site 869309001075 AP binding site [nucleotide binding]; other site 869309001076 metal binding site B [ion binding]; metal-binding site 869309001079 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869309001080 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 869309001081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309001082 Walker A/P-loop; other site 869309001083 ATP binding site [chemical binding]; other site 869309001084 Q-loop/lid; other site 869309001085 ABC transporter signature motif; other site 869309001086 Walker B; other site 869309001087 D-loop; other site 869309001088 H-loop/switch region; other site 869309001089 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869309001090 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869309001091 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 869309001092 Walker A/P-loop; other site 869309001093 ATP binding site [chemical binding]; other site 869309001094 Q-loop/lid; other site 869309001095 ABC transporter signature motif; other site 869309001096 Walker B; other site 869309001097 D-loop; other site 869309001098 H-loop/switch region; other site 869309001099 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 869309001100 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 869309001101 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 869309001102 inhibitor-cofactor binding pocket; inhibition site 869309001103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869309001104 catalytic residue [active] 869309001106 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 869309001107 PhoU domain; Region: PhoU; pfam01895 869309001108 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 869309001109 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 869309001110 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 869309001111 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 869309001112 NAD binding site [chemical binding]; other site 869309001113 homodimer interface [polypeptide binding]; other site 869309001114 active site 869309001115 substrate binding site [chemical binding]; other site 869309001116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 869309001117 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 869309001118 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 869309001119 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869309001120 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869309001121 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309001122 Walker A/P-loop; other site 869309001123 ATP binding site [chemical binding]; other site 869309001124 Q-loop/lid; other site 869309001125 ABC transporter signature motif; other site 869309001126 Walker B; other site 869309001127 D-loop; other site 869309001128 H-loop/switch region; other site 869309001129 TOBE domain; Region: TOBE; pfam03459 869309001130 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 869309001131 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309001132 dimer interface [polypeptide binding]; other site 869309001133 conserved gate region; other site 869309001134 putative PBP binding loops; other site 869309001135 ABC-ATPase subunit interface; other site 869309001136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309001137 putative PBP binding loops; other site 869309001138 dimer interface [polypeptide binding]; other site 869309001139 ABC-ATPase subunit interface; other site 869309001140 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 869309001141 MgtC family; Region: MgtC; pfam02308 869309001142 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869309001143 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869309001144 DNA binding site [nucleotide binding] 869309001145 domain linker motif; other site 869309001146 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 869309001147 putative dimerization interface [polypeptide binding]; other site 869309001148 putative ligand binding site [chemical binding]; other site 869309001149 anthranilate synthase component I; Provisional; Region: PRK13570 869309001150 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 869309001151 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 869309001152 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 869309001153 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 869309001154 glutamine binding [chemical binding]; other site 869309001155 catalytic triad [active] 869309001156 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 869309001157 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869309001158 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869309001159 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 869309001160 active site 869309001161 ribulose/triose binding site [chemical binding]; other site 869309001162 phosphate binding site [ion binding]; other site 869309001163 substrate (anthranilate) binding pocket [chemical binding]; other site 869309001164 product (indole) binding pocket [chemical binding]; other site 869309001165 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 869309001166 active site 869309001167 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 869309001168 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 869309001169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869309001170 catalytic residue [active] 869309001171 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 869309001172 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 869309001173 substrate binding site [chemical binding]; other site 869309001174 active site 869309001175 catalytic residues [active] 869309001176 heterodimer interface [polypeptide binding]; other site 869309001177 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869309001178 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309001179 non-specific DNA binding site [nucleotide binding]; other site 869309001180 salt bridge; other site 869309001181 sequence-specific DNA binding site [nucleotide binding]; other site 869309001182 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 869309001183 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 869309001184 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 869309001185 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 869309001186 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869309001187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869309001188 Coenzyme A binding pocket [chemical binding]; other site 869309001189 MarR family; Region: MarR_2; pfam12802 869309001190 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869309001191 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 869309001193 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 869309001194 arylsulfatase; Provisional; Region: PRK13759 869309001195 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 869309001196 Uncharacterized conserved protein [Function unknown]; Region: COG1262 869309001197 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 869309001198 Integrase core domain; Region: rve; pfam00665 869309001199 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 869309001200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 869309001201 Small integral membrane protein [Function unknown]; Region: COG5547 869309001202 Predicted membrane protein [Function unknown]; Region: COG2261 869309001203 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 869309001204 Mga helix-turn-helix domain; Region: Mga; pfam05043 869309001205 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 869309001206 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869309001207 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869309001208 DNA binding site [nucleotide binding] 869309001209 domain linker motif; other site 869309001210 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 869309001211 dimerization interface [polypeptide binding]; other site 869309001212 ligand binding site [chemical binding]; other site 869309001213 sodium binding site [ion binding]; other site 869309001214 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869309001215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309001216 dimer interface [polypeptide binding]; other site 869309001217 conserved gate region; other site 869309001218 ABC-ATPase subunit interface; other site 869309001219 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869309001220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309001221 dimer interface [polypeptide binding]; other site 869309001222 conserved gate region; other site 869309001223 ABC-ATPase subunit interface; other site 869309001224 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869309001225 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 869309001226 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 869309001227 substrate binding [chemical binding]; other site 869309001228 active site 869309001229 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 869309001230 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869309001231 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869309001232 Replication initiation factor; Region: Rep_trans; pfam02486 869309001233 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 869309001234 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 869309001235 Int/Topo IB signature motif; other site 869309001236 recombination factor protein RarA; Reviewed; Region: PRK13342 869309001237 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309001238 Walker A motif; other site 869309001239 ATP binding site [chemical binding]; other site 869309001240 Walker B motif; other site 869309001241 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 869309001242 arginine finger; other site 869309001243 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 869309001244 YcfA-like protein; Region: YcfA; pfam07927 869309001245 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 869309001246 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 869309001247 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 869309001248 nudix motif; other site 869309001249 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 869309001250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309001251 S-adenosylmethionine binding site [chemical binding]; other site 869309001252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 869309001253 RNA methyltransferase, RsmE family; Region: TIGR00046 869309001254 oligoendopeptidase F; Region: pepF; TIGR00181 869309001255 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 869309001256 Zn binding site [ion binding]; other site 869309001257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869309001258 dimerization interface [polypeptide binding]; other site 869309001259 putative DNA binding site [nucleotide binding]; other site 869309001260 putative Zn2+ binding site [ion binding]; other site 869309001261 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 869309001262 ATP binding site [chemical binding]; other site 869309001263 substrate interface [chemical binding]; other site 869309001264 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 869309001265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309001266 Walker A/P-loop; other site 869309001267 ATP binding site [chemical binding]; other site 869309001268 Q-loop/lid; other site 869309001269 ABC transporter signature motif; other site 869309001270 Walker B; other site 869309001271 D-loop; other site 869309001272 H-loop/switch region; other site 869309001273 ABC-2 type transporter; Region: ABC2_membrane; cl17235 869309001274 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 869309001275 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 869309001276 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 869309001277 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869309001278 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869309001279 catalytic residues [active] 869309001280 MarR family; Region: MarR; pfam01047 869309001281 Predicted membrane protein [Function unknown]; Region: COG4129 869309001282 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 869309001283 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 869309001284 serine/threonine transporter SstT; Provisional; Region: PRK14695 869309001285 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 869309001286 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 869309001287 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 869309001288 Mechanosensitive ion channel; Region: MS_channel; pfam00924 869309001289 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 869309001290 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 869309001291 Cl binding site [ion binding]; other site 869309001292 oligomer interface [polypeptide binding]; other site 869309001293 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 869309001294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309001295 active site 869309001296 motif I; other site 869309001297 motif II; other site 869309001298 GTPase YqeH; Provisional; Region: PRK13796 869309001299 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 869309001300 GTP/Mg2+ binding site [chemical binding]; other site 869309001301 G4 box; other site 869309001302 G5 box; other site 869309001303 G1 box; other site 869309001304 Switch I region; other site 869309001305 G2 box; other site 869309001306 G3 box; other site 869309001307 Switch II region; other site 869309001308 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 869309001309 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 869309001310 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 869309001311 active site 869309001312 (T/H)XGH motif; other site 869309001313 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869309001314 Zn2+ binding site [ion binding]; other site 869309001315 Mg2+ binding site [ion binding]; other site 869309001316 Isochorismatase family; Region: Isochorismatase; pfam00857 869309001317 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 869309001318 catalytic triad [active] 869309001319 conserved cis-peptide bond; other site 869309001320 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 869309001321 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 869309001322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309001323 S-adenosylmethionine binding site [chemical binding]; other site 869309001324 hypothetical protein; Provisional; Region: PRK13670 869309001325 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 869309001326 hypothetical protein; Provisional; Region: PRK00106 869309001327 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869309001328 Zn2+ binding site [ion binding]; other site 869309001329 Mg2+ binding site [ion binding]; other site 869309001330 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 869309001331 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 869309001332 catalytic site [active] 869309001333 G-X2-G-X-G-K; other site 869309001334 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 869309001335 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 869309001336 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869309001337 ATP binding site [chemical binding]; other site 869309001338 putative Mg++ binding site [ion binding]; other site 869309001339 helicase superfamily c-terminal domain; Region: HELICc; smart00490 869309001340 ATP-binding site [chemical binding]; other site 869309001341 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 869309001342 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 869309001343 putative active site [active] 869309001344 substrate binding site [chemical binding]; other site 869309001345 putative cosubstrate binding site; other site 869309001346 catalytic site [active] 869309001347 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 869309001348 substrate binding site [chemical binding]; other site 869309001349 NusB family; Region: NusB; pfam01029 869309001350 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 869309001351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309001352 S-adenosylmethionine binding site [chemical binding]; other site 869309001353 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 869309001354 active site 869309001355 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 869309001356 Catalytic domain of Protein Kinases; Region: PKc; cd00180 869309001357 active site 869309001358 ATP binding site [chemical binding]; other site 869309001359 substrate binding site [chemical binding]; other site 869309001360 activation loop (A-loop); other site 869309001361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 869309001362 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 869309001363 PASTA domain; Region: PASTA; smart00740 869309001364 PASTA domain; Region: PASTA; smart00740 869309001365 PASTA domain; Region: PASTA; smart00740 869309001366 Uncharacterized conserved protein [Function unknown]; Region: COG2966 869309001367 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 869309001368 Uncharacterized conserved protein [Function unknown]; Region: COG3610 869309001369 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 869309001370 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 869309001371 dimer interface [polypeptide binding]; other site 869309001372 active site 869309001373 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 869309001374 homodimer interface [polypeptide binding]; other site 869309001375 catalytic residues [active] 869309001376 NAD binding site [chemical binding]; other site 869309001377 substrate binding pocket [chemical binding]; other site 869309001378 flexible flap; other site 869309001379 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869309001380 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869309001381 DNA binding site [nucleotide binding] 869309001382 domain linker motif; other site 869309001383 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 869309001384 dimerization interface [polypeptide binding]; other site 869309001385 ligand binding site [chemical binding]; other site 869309001386 sodium binding site [ion binding]; other site 869309001387 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 869309001388 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 869309001389 substrate binding [chemical binding]; other site 869309001390 active site 869309001391 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 869309001392 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 869309001393 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869309001394 active site turn [active] 869309001395 phosphorylation site [posttranslational modification] 869309001396 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869309001397 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 869309001398 HPr interaction site; other site 869309001399 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869309001400 active site 869309001401 phosphorylation site [posttranslational modification] 869309001402 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869309001403 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869309001404 nucleotide binding site [chemical binding]; other site 869309001405 Uncharacterized conserved protein [Function unknown]; Region: COG0398 869309001406 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 869309001408 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 869309001409 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309001410 Walker A/P-loop; other site 869309001411 ATP binding site [chemical binding]; other site 869309001412 Q-loop/lid; other site 869309001413 ABC transporter signature motif; other site 869309001414 Walker B; other site 869309001415 D-loop; other site 869309001416 H-loop/switch region; other site 869309001417 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 869309001418 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 869309001419 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 869309001420 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869309001421 Walker A/P-loop; other site 869309001422 ATP binding site [chemical binding]; other site 869309001423 Q-loop/lid; other site 869309001424 ABC transporter signature motif; other site 869309001425 Walker B; other site 869309001426 D-loop; other site 869309001427 H-loop/switch region; other site 869309001428 Predicted transcriptional regulators [Transcription]; Region: COG1725 869309001429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869309001430 DNA-binding site [nucleotide binding]; DNA binding site 869309001431 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 869309001432 ATP cone domain; Region: ATP-cone; pfam03477 869309001433 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 869309001434 primosomal protein DnaI; Reviewed; Region: PRK08939 869309001435 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 869309001436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309001437 Walker A motif; other site 869309001438 ATP binding site [chemical binding]; other site 869309001439 Walker B motif; other site 869309001440 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 869309001441 dimer interface [polypeptide binding]; other site 869309001442 FMN binding site [chemical binding]; other site 869309001443 NADPH bind site [chemical binding]; other site 869309001444 GTP-binding protein Der; Reviewed; Region: PRK00093 869309001445 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 869309001446 G1 box; other site 869309001447 GTP/Mg2+ binding site [chemical binding]; other site 869309001448 Switch I region; other site 869309001449 G2 box; other site 869309001450 Switch II region; other site 869309001451 G3 box; other site 869309001452 G4 box; other site 869309001453 G5 box; other site 869309001454 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 869309001455 G1 box; other site 869309001456 GTP/Mg2+ binding site [chemical binding]; other site 869309001457 Switch I region; other site 869309001458 G2 box; other site 869309001459 G3 box; other site 869309001460 Switch II region; other site 869309001461 G4 box; other site 869309001462 G5 box; other site 869309001464 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 869309001465 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869309001466 Walker A/P-loop; other site 869309001467 ATP binding site [chemical binding]; other site 869309001468 Q-loop/lid; other site 869309001469 ABC transporter signature motif; other site 869309001470 Walker B; other site 869309001471 D-loop; other site 869309001472 H-loop/switch region; other site 869309001473 protein-export membrane protein SecD; Region: secD; TIGR01129 869309001474 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 869309001475 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 869309001476 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869309001477 nucleotide binding region [chemical binding]; other site 869309001478 ATP-binding site [chemical binding]; other site 869309001479 SEC-C motif; Region: SEC-C; pfam02810 869309001480 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 869309001481 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 869309001482 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 869309001483 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 869309001484 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 869309001485 alanine racemase; Reviewed; Region: alr; PRK00053 869309001486 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 869309001487 active site 869309001488 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869309001489 dimer interface [polypeptide binding]; other site 869309001490 substrate binding site [chemical binding]; other site 869309001491 catalytic residues [active] 869309001492 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 869309001493 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 869309001494 ssDNA binding site; other site 869309001495 generic binding surface II; other site 869309001496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869309001497 ATP binding site [chemical binding]; other site 869309001498 putative Mg++ binding site [ion binding]; other site 869309001499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869309001500 nucleotide binding region [chemical binding]; other site 869309001501 ATP-binding site [chemical binding]; other site 869309001502 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 869309001503 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869309001504 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 869309001505 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869309001506 catalytic site [active] 869309001507 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869309001508 Asp-box motif; other site 869309001509 Asp-box motif; other site 869309001510 catalytic site [active] 869309001511 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 869309001512 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869309001513 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869309001514 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869309001515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309001516 dimer interface [polypeptide binding]; other site 869309001517 conserved gate region; other site 869309001518 putative PBP binding loops; other site 869309001519 ABC-ATPase subunit interface; other site 869309001520 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869309001521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309001522 dimer interface [polypeptide binding]; other site 869309001523 conserved gate region; other site 869309001524 putative PBP binding loops; other site 869309001525 ABC-ATPase subunit interface; other site 869309001526 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 869309001527 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 869309001528 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869309001529 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 869309001530 Asp-box motif; other site 869309001531 catalytic site [active] 869309001532 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869309001533 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869309001534 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 869309001535 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 869309001536 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 869309001537 putative active site cavity [active] 869309001538 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 869309001539 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869309001540 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869309001541 active site turn [active] 869309001542 phosphorylation site [posttranslational modification] 869309001543 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869309001544 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 869309001545 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869309001546 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869309001547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309001548 putative PBP binding loops; other site 869309001549 dimer interface [polypeptide binding]; other site 869309001550 ABC-ATPase subunit interface; other site 869309001551 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869309001552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309001553 dimer interface [polypeptide binding]; other site 869309001554 conserved gate region; other site 869309001555 putative PBP binding loops; other site 869309001556 ABC-ATPase subunit interface; other site 869309001557 Domain of unknown function (DUF386); Region: DUF386; pfam04074 869309001559 Protein of unknown function, DUF624; Region: DUF624; pfam04854 869309001560 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 869309001561 Class I aldolases; Region: Aldolase_Class_I; cl17187 869309001562 catalytic residue [active] 869309001563 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 869309001564 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869309001565 nucleotide binding site [chemical binding]; other site 869309001566 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 869309001567 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 869309001568 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 869309001569 putative active site [active] 869309001570 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 869309001571 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869309001572 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869309001573 recombination protein RecR; Reviewed; Region: recR; PRK00076 869309001574 RecR protein; Region: RecR; pfam02132 869309001575 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 869309001576 putative active site [active] 869309001577 putative metal-binding site [ion binding]; other site 869309001578 tetramer interface [polypeptide binding]; other site 869309001579 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 869309001580 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 869309001581 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 869309001582 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 869309001583 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869309001584 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869309001585 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 869309001586 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 869309001587 nudix motif; other site 869309001588 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 869309001589 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 869309001590 Cell division protein FtsA; Region: FtsA; smart00842 869309001591 Cell division protein FtsA; Region: FtsA; pfam14450 869309001592 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 869309001593 cell division protein FtsZ; Validated; Region: PRK09330 869309001594 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 869309001595 nucleotide binding site [chemical binding]; other site 869309001596 SulA interaction site; other site 869309001597 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 869309001598 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869309001599 catalytic residue [active] 869309001600 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 869309001601 YGGT family; Region: YGGT; pfam02325 869309001602 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 869309001603 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869309001604 RNA binding surface [nucleotide binding]; other site 869309001605 DivIVA domain; Region: DivI1A_domain; TIGR03544 869309001606 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 869309001607 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 869309001608 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 869309001609 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869309001610 active site 869309001611 HIGH motif; other site 869309001612 nucleotide binding site [chemical binding]; other site 869309001613 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 869309001614 active site 869309001615 KMSKS motif; other site 869309001616 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 869309001617 tRNA binding surface [nucleotide binding]; other site 869309001618 anticodon binding site; other site 869309001619 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 869309001622 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869309001623 catalytic core [active] 869309001624 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869309001625 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869309001626 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869309001627 Walker A/P-loop; other site 869309001628 ATP binding site [chemical binding]; other site 869309001629 Q-loop/lid; other site 869309001630 ABC transporter signature motif; other site 869309001631 Walker B; other site 869309001632 D-loop; other site 869309001633 H-loop/switch region; other site 869309001635 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 869309001636 dimer interface [polypeptide binding]; other site 869309001637 catalytic triad [active] 869309001638 peroxidatic and resolving cysteines [active] 869309001639 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869309001640 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 869309001641 metal binding site [ion binding]; metal-binding site 869309001642 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 869309001643 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869309001644 ABC-ATPase subunit interface; other site 869309001645 dimer interface [polypeptide binding]; other site 869309001646 putative PBP binding regions; other site 869309001647 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 869309001648 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 869309001649 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 869309001650 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 869309001651 active site 869309001652 Zn binding site [ion binding]; other site 869309001653 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 869309001654 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 869309001655 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869309001656 Zn2+ binding site [ion binding]; other site 869309001657 Mg2+ binding site [ion binding]; other site 869309001658 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869309001659 synthetase active site [active] 869309001660 NTP binding site [chemical binding]; other site 869309001661 metal binding site [ion binding]; metal-binding site 869309001662 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 869309001663 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 869309001664 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 869309001665 putative active site [active] 869309001666 dimerization interface [polypeptide binding]; other site 869309001667 putative tRNAtyr binding site [nucleotide binding]; other site 869309001669 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 869309001670 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 869309001671 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 869309001672 FeoA domain; Region: FeoA; pfam04023 869309001673 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 869309001674 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869309001675 active site 869309001676 metal binding site [ion binding]; metal-binding site 869309001677 Predicted transcriptional regulator [Transcription]; Region: COG1959 869309001678 Transcriptional regulator; Region: Rrf2; pfam02082 869309001679 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 869309001680 nucleophilic elbow; other site 869309001681 catalytic triad; other site 869309001682 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869309001683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309001684 active site 869309001685 phosphorylation site [posttranslational modification] 869309001686 intermolecular recognition site; other site 869309001687 dimerization interface [polypeptide binding]; other site 869309001688 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869309001689 DNA binding site [nucleotide binding] 869309001690 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869309001691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869309001692 ATP binding site [chemical binding]; other site 869309001693 Mg2+ binding site [ion binding]; other site 869309001694 G-X-G motif; other site 869309001695 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 869309001696 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 869309001697 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 869309001698 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 869309001699 active site 869309001700 dimer interface [polypeptide binding]; other site 869309001701 motif 1; other site 869309001702 motif 2; other site 869309001703 motif 3; other site 869309001704 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 869309001705 anticodon binding site; other site 869309001707 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 869309001708 NADH(P)-binding; Region: NAD_binding_10; pfam13460 869309001709 NAD binding site [chemical binding]; other site 869309001710 substrate binding site [chemical binding]; other site 869309001711 putative active site [active] 869309001712 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 869309001713 16S/18S rRNA binding site [nucleotide binding]; other site 869309001714 S13e-L30e interaction site [polypeptide binding]; other site 869309001715 25S rRNA binding site [nucleotide binding]; other site 869309001716 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 869309001717 Cadmium resistance transporter; Region: Cad; pfam03596 869309001718 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 869309001719 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 869309001720 putative acyl-acceptor binding pocket; other site 869309001722 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 869309001723 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 869309001724 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 869309001725 PYR/PP interface [polypeptide binding]; other site 869309001726 dimer interface [polypeptide binding]; other site 869309001727 TPP binding site [chemical binding]; other site 869309001728 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869309001731 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 869309001732 Family of unknown function (DUF633); Region: DUF633; pfam04816 869309001733 Uncharacterized conserved protein [Function unknown]; Region: COG0327 869309001734 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 869309001735 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 869309001736 UDP-glucose 4-epimerase; Region: PLN02240 869309001737 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 869309001738 NAD binding site [chemical binding]; other site 869309001739 homodimer interface [polypeptide binding]; other site 869309001740 active site 869309001741 substrate binding site [chemical binding]; other site 869309001742 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 869309001743 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 869309001744 Ligand binding site; other site 869309001745 Putative Catalytic site; other site 869309001746 DXD motif; other site 869309001747 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 869309001748 cytidylate kinase; Provisional; Region: cmk; PRK00023 869309001749 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 869309001750 CMP-binding site; other site 869309001751 The sites determining sugar specificity; other site 869309001752 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 869309001753 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 869309001754 PhnA protein; Region: PhnA; pfam03831 869309001755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869309001756 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 869309001757 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 869309001758 dimerization interface 3.5A [polypeptide binding]; other site 869309001759 active site 869309001760 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 869309001761 dimer interface [polypeptide binding]; other site 869309001762 substrate binding site [chemical binding]; other site 869309001763 ATP binding site [chemical binding]; other site 869309001764 Predicted membrane protein [Function unknown]; Region: COG4720 869309001766 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869309001767 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 869309001768 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 869309001769 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 869309001770 active site 869309001771 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 869309001772 catalytic triad [active] 869309001773 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 869309001774 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869309001775 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 869309001776 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 869309001777 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 869309001778 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869309001779 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869309001781 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 869309001782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 869309001783 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869309001784 nucleotide binding region [chemical binding]; other site 869309001785 ATP-binding site [chemical binding]; other site 869309001786 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 869309001787 CodY GAF-like domain; Region: CodY; pfam06018 869309001788 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869309001789 dimerization interface [polypeptide binding]; other site 869309001790 putative Zn2+ binding site [ion binding]; other site 869309001791 putative DNA binding site [nucleotide binding]; other site 869309001792 similar to Nicotinamidase (EC 3.5.1.19) (pseudogene) 869309001793 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 869309001794 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 869309001795 Walker A/P-loop; other site 869309001796 ATP binding site [chemical binding]; other site 869309001797 Q-loop/lid; other site 869309001798 ABC transporter signature motif; other site 869309001799 Walker B; other site 869309001800 D-loop; other site 869309001801 H-loop/switch region; other site 869309001802 TOBE domain; Region: TOBE_2; pfam08402 869309001803 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869309001804 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309001805 S-adenosylmethionine binding site [chemical binding]; other site 869309001806 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869309001807 active site 869309001808 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 869309001809 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 869309001810 proposed active site lysine [active] 869309001811 conserved cys residue [active] 869309001812 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 869309001813 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 869309001814 triosephosphate isomerase; Provisional; Region: PRK14567 869309001815 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 869309001816 substrate binding site [chemical binding]; other site 869309001817 dimer interface [polypeptide binding]; other site 869309001818 catalytic triad [active] 869309001819 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869309001820 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 869309001821 active site 869309001822 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 869309001823 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 869309001824 dimerization interface [polypeptide binding]; other site 869309001825 DPS ferroxidase diiron center [ion binding]; other site 869309001826 ion pore; other site 869309001827 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 869309001828 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 869309001829 folate binding site [chemical binding]; other site 869309001830 NADP+ binding site [chemical binding]; other site 869309001831 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 869309001832 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 869309001833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309001834 Walker A motif; other site 869309001835 ATP binding site [chemical binding]; other site 869309001836 Walker B motif; other site 869309001837 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869309001838 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 869309001839 G1 box; other site 869309001840 GTP/Mg2+ binding site [chemical binding]; other site 869309001841 Switch I region; other site 869309001842 G2 box; other site 869309001843 G3 box; other site 869309001844 Switch II region; other site 869309001845 G4 box; other site 869309001846 G5 box; other site 869309001847 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 869309001848 homotrimer interaction site [polypeptide binding]; other site 869309001849 putative active site [active] 869309001850 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 869309001851 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 869309001852 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 869309001853 dimer interface [polypeptide binding]; other site 869309001854 phosphate binding site [ion binding]; other site 869309001855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 869309001856 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 869309001857 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 869309001858 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869309001859 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869309001860 Uncharacterized conserved protein [Function unknown]; Region: COG1624 869309001861 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 869309001862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 869309001863 YbbR-like protein; Region: YbbR; pfam07949 869309001864 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 869309001865 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 869309001866 active site 869309001867 substrate binding site [chemical binding]; other site 869309001868 metal binding site [ion binding]; metal-binding site 869309001870 dihydrodipicolinate reductase; Provisional; Region: PRK00048 869309001871 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 869309001872 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 869309001873 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 869309001874 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 869309001875 active site 869309001876 NTP binding site [chemical binding]; other site 869309001877 metal binding triad [ion binding]; metal-binding site 869309001878 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 869309001879 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 869309001880 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869309001881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309001882 Walker A/P-loop; other site 869309001883 ATP binding site [chemical binding]; other site 869309001884 Q-loop/lid; other site 869309001885 ABC transporter signature motif; other site 869309001886 Walker B; other site 869309001887 D-loop; other site 869309001888 H-loop/switch region; other site 869309001889 ABC transporter; Region: ABC_tran_2; pfam12848 869309001890 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869309001891 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 869309001892 Cation efflux family; Region: Cation_efflux; pfam01545 869309001893 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 869309001894 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 869309001895 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 869309001896 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869309001897 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 869309001898 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 869309001899 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 869309001900 putative S-transferase; Provisional; Region: PRK11752 869309001901 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 869309001902 C-terminal domain interface [polypeptide binding]; other site 869309001903 GSH binding site (G-site) [chemical binding]; other site 869309001904 dimer interface [polypeptide binding]; other site 869309001905 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 869309001906 dimer interface [polypeptide binding]; other site 869309001907 N-terminal domain interface [polypeptide binding]; other site 869309001908 active site 869309001909 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234 869309001910 active site 869309001911 catalytic residues [active] 869309001912 metal binding site [ion binding]; metal-binding site 869309001913 Protein of unknown function (DUF3953); Region: DUF3953; pfam13129 869309001914 hypothetical protein; Validated; Region: PRK02101 869309001915 Predicted flavoprotein [General function prediction only]; Region: COG0431 869309001916 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869309001917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 869309001918 aspartate aminotransferase; Provisional; Region: PRK05764 869309001919 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869309001920 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869309001921 homodimer interface [polypeptide binding]; other site 869309001922 catalytic residue [active] 869309001923 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 869309001924 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869309001925 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 869309001926 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 869309001927 putative dimer interface [polypeptide binding]; other site 869309001928 putative anticodon binding site; other site 869309001929 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 869309001930 homodimer interface [polypeptide binding]; other site 869309001931 motif 1; other site 869309001932 motif 2; other site 869309001933 active site 869309001934 motif 3; other site 869309001935 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 869309001936 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 869309001937 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 869309001938 dimer interface [polypeptide binding]; other site 869309001939 ssDNA binding site [nucleotide binding]; other site 869309001940 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869309001941 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 869309001943 hypothetical protein; Provisional; Region: PRK07252 869309001944 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 869309001945 RNA binding site [nucleotide binding]; other site 869309001946 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 869309001947 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309001948 S-adenosylmethionine binding site [chemical binding]; other site 869309001949 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 869309001950 GIY-YIG motif/motif A; other site 869309001951 putative active site [active] 869309001952 putative metal binding site [ion binding]; other site 869309001953 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 869309001954 DHH family; Region: DHH; pfam01368 869309001955 DHHA2 domain; Region: DHHA2; pfam02833 869309001956 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 869309001957 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 869309001958 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 869309001959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 869309001960 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 869309001961 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869309001962 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869309001963 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869309001964 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869309001965 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 869309001966 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 869309001967 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 869309001968 peptide binding site [polypeptide binding]; other site 869309001970 cystathionine gamma-synthase; Reviewed; Region: PRK07269 869309001971 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 869309001972 homodimer interface [polypeptide binding]; other site 869309001973 substrate-cofactor binding pocket; other site 869309001974 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869309001975 catalytic residue [active] 869309001976 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 869309001977 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869309001978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869309001979 homodimer interface [polypeptide binding]; other site 869309001980 catalytic residue [active] 869309001981 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 869309001982 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 869309001983 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869309001984 ATP binding site [chemical binding]; other site 869309001985 putative Mg++ binding site [ion binding]; other site 869309001986 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869309001987 nucleotide binding region [chemical binding]; other site 869309001988 ATP-binding site [chemical binding]; other site 869309001989 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 869309001990 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 869309001991 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869309001992 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869309001993 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869309001994 Coenzyme A binding pocket [chemical binding]; other site 869309001995 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 869309001996 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869309001997 Coenzyme A binding pocket [chemical binding]; other site 869309001998 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 869309001999 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 869309002000 dimerization interface [polypeptide binding]; other site 869309002001 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 869309002002 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 869309002003 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 869309002008 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 869309002009 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 869309002010 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 869309002011 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 869309002012 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 869309002013 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 869309002014 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 869309002015 F0F1-type ATP synthase, alpha subunit [Energy production and conversion]; Region: AtpA; COG0056 869309002016 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869309002017 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 869309002018 beta subunit interaction interface [polypeptide binding]; other site 869309002019 Walker A motif; other site 869309002020 ATP binding site [chemical binding]; other site 869309002021 Walker B motif; other site 869309002022 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869309002023 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 869309002024 core domain interface [polypeptide binding]; other site 869309002025 delta subunit interface [polypeptide binding]; other site 869309002026 epsilon subunit interface [polypeptide binding]; other site 869309002027 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 869309002028 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 869309002029 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 869309002030 alpha subunit interaction interface [polypeptide binding]; other site 869309002031 Walker A motif; other site 869309002032 ATP binding site [chemical binding]; other site 869309002033 Walker B motif; other site 869309002034 inhibitor binding site; inhibition site 869309002035 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 869309002036 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 869309002037 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 869309002038 gamma subunit interface [polypeptide binding]; other site 869309002039 epsilon subunit interface [polypeptide binding]; other site 869309002040 LBP interface [polypeptide binding]; other site 869309002041 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 869309002042 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 869309002043 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869309002044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 869309002045 TPR motif; other site 869309002046 binding surface 869309002047 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 869309002048 binding surface 869309002049 TPR motif; other site 869309002050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309002051 dimer interface [polypeptide binding]; other site 869309002052 conserved gate region; other site 869309002053 putative PBP binding loops; other site 869309002054 ABC-ATPase subunit interface; other site 869309002055 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869309002056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309002057 Walker A/P-loop; other site 869309002058 ATP binding site [chemical binding]; other site 869309002059 Q-loop/lid; other site 869309002060 ABC transporter signature motif; other site 869309002061 Walker B; other site 869309002062 D-loop; other site 869309002063 H-loop/switch region; other site 869309002064 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869309002065 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869309002066 substrate binding pocket [chemical binding]; other site 869309002067 membrane-bound complex binding site; other site 869309002068 hinge residues; other site 869309002069 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 869309002070 catalytic residues [active] 869309002071 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 869309002072 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 869309002073 active site 869309002074 substrate binding site [chemical binding]; other site 869309002075 metal binding site [ion binding]; metal-binding site 869309002077 MucBP domain; Region: MucBP; pfam06458 869309002078 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 869309002079 amphipathic channel; other site 869309002080 Asn-Pro-Ala signature motifs; other site 869309002081 elongation factor Tu; Reviewed; Region: PRK00049 869309002082 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 869309002083 G1 box; other site 869309002084 GEF interaction site [polypeptide binding]; other site 869309002085 GTP/Mg2+ binding site [chemical binding]; other site 869309002086 Switch I region; other site 869309002087 G2 box; other site 869309002088 G3 box; other site 869309002089 Switch II region; other site 869309002090 G4 box; other site 869309002091 G5 box; other site 869309002092 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 869309002093 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 869309002094 Antibiotic Binding Site [chemical binding]; other site 869309002095 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 869309002096 DEAD-like helicases superfamily; Region: DEXDc; smart00487 869309002097 ATP binding site [chemical binding]; other site 869309002098 putative Mg++ binding site [ion binding]; other site 869309002099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869309002100 nucleotide binding region [chemical binding]; other site 869309002101 ATP-binding site [chemical binding]; other site 869309002102 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 869309002103 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869309002104 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 869309002105 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 869309002106 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 869309002107 NodB motif; other site 869309002108 active site 869309002109 catalytic site [active] 869309002110 Zn binding site [ion binding]; other site 869309002111 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869309002112 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869309002113 active site 869309002114 catalytic tetrad [active] 869309002116 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 869309002117 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 869309002118 dimer interface [polypeptide binding]; other site 869309002119 motif 1; other site 869309002120 active site 869309002121 motif 2; other site 869309002122 motif 3; other site 869309002123 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 869309002124 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 869309002125 DALR anticodon binding domain; Region: DALR_1; pfam05746 869309002126 hypothetical protein; Provisional; Region: PRK02539 869309002127 Predicted flavoprotein [General function prediction only]; Region: COG0431 869309002128 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869309002129 PAS domain; Region: PAS_10; pfam13596 869309002130 Predicted flavoprotein [General function prediction only]; Region: COG0431 869309002131 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 869309002132 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 869309002133 ApbE family; Region: ApbE; pfam02424 869309002134 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 869309002135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869309002136 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869309002137 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 869309002138 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 869309002139 active site 869309002140 multimer interface [polypeptide binding]; other site 869309002141 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 869309002142 predicted active site [active] 869309002143 catalytic triad [active] 869309002144 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 869309002145 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 869309002148 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 869309002149 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 869309002150 DNA binding site [nucleotide binding] 869309002151 active site 869309002152 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 869309002153 putative ArsC-like catalytic residues; other site 869309002154 putative TRX-like catalytic residues [active] 869309002155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869309002156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309002157 ABC-ATPase subunit interface; other site 869309002158 putative PBP binding loops; other site 869309002159 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869309002160 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869309002161 Walker A/P-loop; other site 869309002162 ATP binding site [chemical binding]; other site 869309002163 Q-loop/lid; other site 869309002164 ABC transporter signature motif; other site 869309002165 Walker B; other site 869309002166 D-loop; other site 869309002167 H-loop/switch region; other site 869309002168 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 869309002169 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 869309002170 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 869309002171 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869309002172 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 869309002173 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 869309002174 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 869309002175 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 869309002176 active site 869309002177 catalytic residues [active] 869309002178 metal binding site [ion binding]; metal-binding site 869309002179 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 869309002180 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 869309002181 putative active site [active] 869309002182 putative metal binding site [ion binding]; other site 869309002183 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869309002184 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309002185 active site 869309002186 motif I; other site 869309002187 motif II; other site 869309002188 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309002189 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 869309002190 active site 869309002191 catalytic triad [active] 869309002192 oxyanion hole [active] 869309002193 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 869309002194 Beta-lactamase; Region: Beta-lactamase; pfam00144 869309002195 EamA-like transporter family; Region: EamA; pfam00892 869309002196 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869309002197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869309002198 DNA-binding site [nucleotide binding]; DNA binding site 869309002199 UTRA domain; Region: UTRA; pfam07702 869309002200 GMP synthase; Reviewed; Region: guaA; PRK00074 869309002201 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 869309002202 AMP/PPi binding site [chemical binding]; other site 869309002203 candidate oxyanion hole; other site 869309002204 catalytic triad [active] 869309002205 potential glutamine specificity residues [chemical binding]; other site 869309002206 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 869309002207 ATP Binding subdomain [chemical binding]; other site 869309002208 Dimerization subdomain; other site 869309002210 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 869309002212 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869309002213 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869309002214 Walker A/P-loop; other site 869309002215 ATP binding site [chemical binding]; other site 869309002216 Q-loop/lid; other site 869309002217 ABC transporter signature motif; other site 869309002218 Walker B; other site 869309002219 D-loop; other site 869309002220 H-loop/switch region; other site 869309002221 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869309002222 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309002223 Walker A/P-loop; other site 869309002224 ATP binding site [chemical binding]; other site 869309002225 Q-loop/lid; other site 869309002226 ABC transporter signature motif; other site 869309002227 Walker B; other site 869309002228 D-loop; other site 869309002229 H-loop/switch region; other site 869309002230 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869309002231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309002232 Walker A/P-loop; other site 869309002233 ATP binding site [chemical binding]; other site 869309002234 Q-loop/lid; other site 869309002235 ABC transporter signature motif; other site 869309002236 Walker B; other site 869309002237 D-loop; other site 869309002238 H-loop/switch region; other site 869309002239 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869309002240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309002241 Walker A/P-loop; other site 869309002242 ATP binding site [chemical binding]; other site 869309002243 Q-loop/lid; other site 869309002244 ABC transporter signature motif; other site 869309002245 Walker B; other site 869309002246 D-loop; other site 869309002247 H-loop/switch region; other site 869309002248 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869309002249 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869309002250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309002251 Walker A/P-loop; other site 869309002252 ATP binding site [chemical binding]; other site 869309002253 Q-loop/lid; other site 869309002254 ABC transporter signature motif; other site 869309002255 Walker B; other site 869309002256 D-loop; other site 869309002257 H-loop/switch region; other site 869309002258 Helix-turn-helix domain; Region: HTH_18; pfam12833 869309002259 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869309002260 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 869309002261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309002262 S-adenosylmethionine binding site [chemical binding]; other site 869309002263 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 869309002264 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869309002265 Peptidase family U32; Region: Peptidase_U32; pfam01136 869309002266 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869309002267 Peptidase family U32; Region: Peptidase_U32; pfam01136 869309002268 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869309002269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309002270 ABC transporter; Region: ABC_tran; pfam00005 869309002271 Q-loop/lid; other site 869309002272 ABC transporter signature motif; other site 869309002273 Walker B; other site 869309002274 D-loop; other site 869309002275 H-loop/switch region; other site 869309002277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309002278 non-specific DNA binding site [nucleotide binding]; other site 869309002279 salt bridge; other site 869309002280 sequence-specific DNA binding site [nucleotide binding]; other site 869309002281 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 869309002282 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 869309002283 active site 869309002284 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 869309002285 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 869309002286 homodimer interface [polypeptide binding]; other site 869309002287 NAD binding pocket [chemical binding]; other site 869309002288 ATP binding pocket [chemical binding]; other site 869309002289 Mg binding site [ion binding]; other site 869309002290 active-site loop [active] 869309002291 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 869309002292 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869309002293 G5 domain; Region: G5; pfam07501 869309002294 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309002295 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 869309002296 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309002297 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 869309002298 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 869309002299 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 869309002300 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 869309002301 active site 869309002302 trimer interface [polypeptide binding]; other site 869309002303 allosteric site; other site 869309002304 active site lid [active] 869309002305 hexamer (dimer of trimers) interface [polypeptide binding]; other site 869309002306 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 869309002307 HPr kinase/phosphorylase; Provisional; Region: PRK05428 869309002308 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 869309002309 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 869309002310 Hpr binding site; other site 869309002311 active site 869309002312 homohexamer subunit interaction site [polypeptide binding]; other site 869309002313 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 869309002314 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 869309002315 YtxH-like protein; Region: YtxH; pfam12732 869309002316 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 869309002317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869309002318 FeS/SAM binding site; other site 869309002319 HemN C-terminal domain; Region: HemN_C; pfam06969 869309002320 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 869309002321 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869309002322 active site 869309002323 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 869309002324 active site 869309002325 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 869309002326 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309002327 active site 869309002328 motif I; other site 869309002329 motif II; other site 869309002330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309002331 Predicted membrane protein [Function unknown]; Region: COG4478 869309002332 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 869309002333 ArsC family; Region: ArsC; pfam03960 869309002334 putative catalytic residues [active] 869309002335 thiol/disulfide switch; other site 869309002336 hypothetical protein; Provisional; Region: PRK04387 869309002337 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 869309002338 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 869309002339 active site 869309002340 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 869309002341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309002342 S-adenosylmethionine binding site [chemical binding]; other site 869309002343 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 869309002344 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 869309002345 phosphate binding protein; Region: ptsS_2; TIGR02136 869309002346 sulfate transport protein; Provisional; Region: cysT; CHL00187 869309002347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309002348 dimer interface [polypeptide binding]; other site 869309002349 conserved gate region; other site 869309002350 putative PBP binding loops; other site 869309002351 ABC-ATPase subunit interface; other site 869309002352 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 869309002353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309002354 dimer interface [polypeptide binding]; other site 869309002355 conserved gate region; other site 869309002356 putative PBP binding loops; other site 869309002357 ABC-ATPase subunit interface; other site 869309002358 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 869309002359 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869309002360 Walker A/P-loop; other site 869309002361 ATP binding site [chemical binding]; other site 869309002362 Q-loop/lid; other site 869309002363 ABC transporter signature motif; other site 869309002364 Walker B; other site 869309002365 D-loop; other site 869309002366 H-loop/switch region; other site 869309002367 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 869309002368 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 869309002369 Walker A/P-loop; other site 869309002370 ATP binding site [chemical binding]; other site 869309002371 Q-loop/lid; other site 869309002372 ABC transporter signature motif; other site 869309002373 Walker B; other site 869309002374 D-loop; other site 869309002375 H-loop/switch region; other site 869309002376 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 869309002377 PhoU domain; Region: PhoU; pfam01895 869309002378 PhoU domain; Region: PhoU; pfam01895 869309002380 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 869309002381 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869309002382 DNA-binding site [nucleotide binding]; DNA binding site 869309002383 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869309002384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869309002385 homodimer interface [polypeptide binding]; other site 869309002386 catalytic residue [active] 869309002387 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 869309002388 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 869309002389 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 869309002390 FAD binding domain; Region: FAD_binding_4; pfam01565 869309002391 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 869309002392 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869309002393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309002394 Q-loop/lid; other site 869309002395 ABC transporter signature motif; other site 869309002396 Walker B; other site 869309002397 D-loop; other site 869309002398 H-loop/switch region; other site 869309002399 TOBE domain; Region: TOBE_2; pfam08402 869309002400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309002401 dimer interface [polypeptide binding]; other site 869309002402 conserved gate region; other site 869309002403 putative PBP binding loops; other site 869309002404 ABC-ATPase subunit interface; other site 869309002405 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 869309002406 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309002407 dimer interface [polypeptide binding]; other site 869309002408 conserved gate region; other site 869309002409 putative PBP binding loops; other site 869309002410 ABC-ATPase subunit interface; other site 869309002411 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 869309002412 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 869309002413 Uncharacterized conserved protein [Function unknown]; Region: COG4894 869309002414 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 869309002415 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 869309002416 motif 1; other site 869309002417 active site 869309002418 motif 2; other site 869309002419 motif 3; other site 869309002420 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 869309002421 DHHA1 domain; Region: DHHA1; pfam02272 869309002422 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 869309002423 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 869309002424 active site 869309002425 Na/Ca binding site [ion binding]; other site 869309002426 catalytic site [active] 869309002427 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 869309002428 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 869309002429 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869309002430 Walker A/P-loop; other site 869309002431 ATP binding site [chemical binding]; other site 869309002432 Q-loop/lid; other site 869309002433 ABC transporter signature motif; other site 869309002434 Walker B; other site 869309002435 D-loop; other site 869309002436 H-loop/switch region; other site 869309002438 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 869309002439 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 869309002440 putative RNA binding site [nucleotide binding]; other site 869309002441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309002442 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 869309002443 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 869309002444 active site 869309002445 catalytic residue [active] 869309002446 dimer interface [polypeptide binding]; other site 869309002447 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 869309002448 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 869309002449 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 869309002450 shikimate binding site; other site 869309002451 NAD(P) binding site [chemical binding]; other site 869309002452 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 869309002453 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 869309002454 active site 869309002455 dimer interface [polypeptide binding]; other site 869309002456 metal binding site [ion binding]; metal-binding site 869309002457 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 869309002458 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 869309002459 Tetramer interface [polypeptide binding]; other site 869309002460 active site 869309002461 FMN-binding site [chemical binding]; other site 869309002462 prephenate dehydrogenase; Validated; Region: PRK06545 869309002463 prephenate dehydrogenase; Validated; Region: PRK08507 869309002464 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 869309002465 hypothetical protein; Provisional; Region: PRK13676 869309002466 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 869309002467 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 869309002468 hinge; other site 869309002469 active site 869309002470 shikimate kinase; Reviewed; Region: aroK; PRK00131 869309002471 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 869309002472 ADP binding site [chemical binding]; other site 869309002473 magnesium binding site [ion binding]; other site 869309002474 putative shikimate binding site; other site 869309002475 prephenate dehydratase; Provisional; Region: PRK11898 869309002476 Prephenate dehydratase; Region: PDT; pfam00800 869309002477 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 869309002478 putative L-Phe binding site [chemical binding]; other site 869309002479 Transcriptional regulator [Transcription]; Region: LytR; COG1316 869309002480 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 869309002481 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869309002482 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 869309002483 putative ADP-binding pocket [chemical binding]; other site 869309002484 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 869309002485 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869309002486 active site 869309002487 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 869309002488 adaptor protein; Provisional; Region: PRK02315 869309002489 homoserine dehydrogenase; Provisional; Region: PRK06349 869309002490 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 869309002491 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 869309002492 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 869309002493 homoserine kinase; Provisional; Region: PRK01212 869309002494 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869309002495 homoserine kinase; Provisional; Region: PRK01212 869309002496 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869309002497 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 869309002498 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 869309002499 SelR domain; Region: SelR; pfam01641 869309002500 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869309002501 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869309002502 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309002503 Walker A/P-loop; other site 869309002504 ATP binding site [chemical binding]; other site 869309002505 Q-loop/lid; other site 869309002506 ABC transporter signature motif; other site 869309002507 Walker B; other site 869309002508 D-loop; other site 869309002509 H-loop/switch region; other site 869309002510 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 869309002511 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869309002512 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 869309002513 Walker A/P-loop; other site 869309002514 ATP binding site [chemical binding]; other site 869309002515 Q-loop/lid; other site 869309002516 ABC transporter signature motif; other site 869309002517 Walker B; other site 869309002518 D-loop; other site 869309002519 H-loop/switch region; other site 869309002521 chlorohydrolase; Validated; Region: PRK06687 869309002522 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 869309002523 active site 869309002524 putative substrate binding pocket [chemical binding]; other site 869309002525 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 869309002526 23S rRNA interface [nucleotide binding]; other site 869309002527 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 869309002528 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 869309002529 core dimer interface [polypeptide binding]; other site 869309002530 L10 interface [polypeptide binding]; other site 869309002531 L11 interface [polypeptide binding]; other site 869309002532 putative EF-Tu interaction site [polypeptide binding]; other site 869309002533 putative EF-G interaction site [polypeptide binding]; other site 869309002534 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 869309002535 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869309002536 active site 869309002537 DNA binding site [nucleotide binding] 869309002538 Int/Topo IB signature motif; other site 869309002539 PemK-like protein; Region: PemK; pfam02452 869309002540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309002541 non-specific DNA binding site [nucleotide binding]; other site 869309002542 salt bridge; other site 869309002543 sequence-specific DNA binding site [nucleotide binding]; other site 869309002544 Predicted transcriptional regulator [Transcription]; Region: COG2932 869309002545 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 869309002546 Catalytic site [active] 869309002547 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 869309002548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309002549 non-specific DNA binding site [nucleotide binding]; other site 869309002550 salt bridge; other site 869309002551 sequence-specific DNA binding site [nucleotide binding]; other site 869309002552 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869309002553 putative DNA binding site [nucleotide binding]; other site 869309002554 putative Zn2+ binding site [ion binding]; other site 869309002555 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 869309002557 V-type ATP synthase subunit K; Validated; Region: PRK06558 869309002558 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 869309002559 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 869309002560 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 869309002561 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 869309002562 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 869309002563 V-type ATP synthase subunit F; Provisional; Region: PRK01395 869309002566 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 869309002567 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869309002568 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 869309002569 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 869309002572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309002573 ABC transporter signature motif; other site 869309002574 Walker B; other site 869309002575 D-loop; other site 869309002576 H-loop/switch region; other site 869309002577 glutamate dehydrogenase; Provisional; Region: PRK09414 869309002578 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 869309002579 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 869309002580 NAD(P) binding site [chemical binding]; other site 869309002583 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 869309002584 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 869309002585 DHH family; Region: DHH; pfam01368 869309002586 flavodoxin; Validated; Region: PRK07308 869309002587 hypothetical protein; Provisional; Region: PRK07248 869309002588 camphor resistance protein CrcB; Provisional; Region: PRK14221 869309002589 camphor resistance protein CrcB; Provisional; Region: PRK14229 869309002590 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 869309002591 SAP domain; Region: SAP; pfam02037 869309002592 sugar phosphate phosphatase; Provisional; Region: PRK10513 869309002593 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309002594 active site 869309002595 motif I; other site 869309002596 motif II; other site 869309002597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309002598 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 869309002599 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 869309002600 Zn2+ binding site [ion binding]; other site 869309002601 Mg2+ binding site [ion binding]; other site 869309002602 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 869309002603 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 869309002604 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 869309002605 signal recognition particle protein; Provisional; Region: PRK10867 869309002606 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 869309002607 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 869309002608 P loop; other site 869309002609 GTP binding site [chemical binding]; other site 869309002610 Signal peptide binding domain; Region: SRP_SPB; pfam02978 869309002611 uracil transporter; Provisional; Region: PRK10720 869309002612 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 869309002613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309002614 S-adenosylmethionine binding site [chemical binding]; other site 869309002615 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 869309002616 heat shock protein HtpX; Provisional; Region: PRK04897 869309002618 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 869309002619 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 869309002620 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869309002621 minor groove reading motif; other site 869309002622 helix-hairpin-helix signature motif; other site 869309002623 substrate binding pocket [chemical binding]; other site 869309002624 active site 869309002625 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 869309002626 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869309002627 active site 869309002628 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 869309002629 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869309002630 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869309002631 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 869309002632 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 869309002633 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 869309002634 catalytic site [active] 869309002635 subunit interface [polypeptide binding]; other site 869309002636 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 869309002637 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869309002638 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869309002639 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 869309002640 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869309002641 ATP-grasp domain; Region: ATP-grasp_4; cl17255 869309002642 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 869309002643 IMP binding site; other site 869309002644 dimer interface [polypeptide binding]; other site 869309002645 interdomain contacts; other site 869309002646 partial ornithine binding site; other site 869309002647 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 869309002648 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 869309002649 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 869309002650 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 869309002651 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 869309002652 substrate binding site; other site 869309002653 dimer interface; other site 869309002654 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 869309002655 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 869309002656 putative NAD(P) binding site [chemical binding]; other site 869309002657 putative catalytic Zn binding site [ion binding]; other site 869309002658 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 869309002659 Phosphotransferase enzyme family; Region: APH; pfam01636 869309002660 active site 869309002661 substrate binding site [chemical binding]; other site 869309002662 ATP binding site [chemical binding]; other site 869309002663 dimer interface [polypeptide binding]; other site 869309002664 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 869309002665 active site 869309002666 metal-binding site 869309002667 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 869309002668 DNA protecting protein DprA; Region: dprA; TIGR00732 869309002669 Predicted membrane protein [Function unknown]; Region: COG1808 869309002670 DNA topoisomerase I; Validated; Region: PRK05582 869309002671 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 869309002672 active site 869309002673 metal binding site [ion binding]; metal-binding site 869309002674 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 869309002675 domain I; other site 869309002676 DNA binding groove [nucleotide binding] 869309002677 phosphate binding site [ion binding]; other site 869309002678 domain II; other site 869309002679 domain III; other site 869309002680 nucleotide binding site [chemical binding]; other site 869309002681 catalytic site [active] 869309002682 domain IV; other site 869309002683 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869309002684 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 869309002685 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 869309002686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 869309002687 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 869309002688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 869309002689 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 869309002690 metal binding site [ion binding]; metal-binding site 869309002691 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 869309002692 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 869309002693 tartrate dehydrogenase; Region: TTC; TIGR02089 869309002694 Predicted membrane protein [Function unknown]; Region: COG3326 869309002695 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 869309002696 substrate binding site [chemical binding]; other site 869309002697 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 869309002698 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 869309002699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309002700 Walker A motif; other site 869309002701 ATP binding site [chemical binding]; other site 869309002702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 869309002703 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 869309002704 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 869309002705 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869309002706 active site 869309002707 ribonuclease III; Reviewed; Region: rnc; PRK00102 869309002708 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 869309002709 dimerization interface [polypeptide binding]; other site 869309002710 active site 869309002711 metal binding site [ion binding]; metal-binding site 869309002712 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 869309002713 dsRNA binding site [nucleotide binding]; other site 869309002714 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 869309002715 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 869309002716 Walker A/P-loop; other site 869309002717 ATP binding site [chemical binding]; other site 869309002718 Q-loop/lid; other site 869309002719 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 869309002720 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 869309002721 ABC transporter signature motif; other site 869309002722 Walker B; other site 869309002723 D-loop; other site 869309002724 H-loop/switch region; other site 869309002725 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869309002726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309002727 non-specific DNA binding site [nucleotide binding]; other site 869309002728 salt bridge; other site 869309002729 sequence-specific DNA binding site [nucleotide binding]; other site 869309002730 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869309002731 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 869309002732 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869309002733 catalytic residue [active] 869309002734 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 869309002735 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 869309002736 acyl-activating enzyme (AAE) consensus motif; other site 869309002737 AMP binding site [chemical binding]; other site 869309002738 active site 869309002739 CoA binding site [chemical binding]; other site 869309002740 H+ Antiporter protein; Region: 2A0121; TIGR00900 869309002741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869309002742 putative substrate translocation pore; other site 869309002744 Recombinase; Region: Recombinase; pfam07508 869309002745 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869309002746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309002747 active site 869309002748 motif I; other site 869309002749 motif II; other site 869309002750 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 869309002751 sugar phosphate phosphatase; Provisional; Region: PRK10513 869309002752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309002753 motif II; other site 869309002754 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309002755 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 869309002756 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 869309002757 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 869309002758 P loop; other site 869309002759 GTP binding site [chemical binding]; other site 869309002760 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 869309002761 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 869309002762 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 869309002763 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869309002764 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869309002765 Walker A/P-loop; other site 869309002766 ATP binding site [chemical binding]; other site 869309002767 Q-loop/lid; other site 869309002768 ABC transporter signature motif; other site 869309002769 Walker B; other site 869309002770 D-loop; other site 869309002771 H-loop/switch region; other site 869309002772 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869309002773 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869309002774 substrate binding pocket [chemical binding]; other site 869309002775 membrane-bound complex binding site; other site 869309002776 hinge residues; other site 869309002777 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869309002778 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869309002779 substrate binding pocket [chemical binding]; other site 869309002780 membrane-bound complex binding site; other site 869309002781 hinge residues; other site 869309002782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309002783 dimer interface [polypeptide binding]; other site 869309002784 conserved gate region; other site 869309002785 putative PBP binding loops; other site 869309002786 ABC-ATPase subunit interface; other site 869309002787 CAAX protease self-immunity; Region: Abi; pfam02517 869309002788 excinuclease ABC subunit B; Provisional; Region: PRK05298 869309002789 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869309002790 ATP binding site [chemical binding]; other site 869309002791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869309002792 nucleotide binding region [chemical binding]; other site 869309002793 ATP-binding site [chemical binding]; other site 869309002794 Ultra-violet resistance protein B; Region: UvrB; pfam12344 869309002795 UvrB/uvrC motif; Region: UVR; pfam02151 869309002796 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869309002797 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869309002798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869309002799 Coenzyme A binding pocket [chemical binding]; other site 869309002801 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 869309002802 HTH domain; Region: HTH_11; pfam08279 869309002803 3H domain; Region: 3H; pfam02829 869309002804 Predicted membrane protein [Function unknown]; Region: COG4684 869309002805 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 869309002806 Flavoprotein; Region: Flavoprotein; pfam02441 869309002807 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 869309002808 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 869309002809 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 869309002810 Potassium binding sites [ion binding]; other site 869309002811 Cesium cation binding sites [ion binding]; other site 869309002812 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 869309002813 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 869309002814 minor groove reading motif; other site 869309002815 helix-hairpin-helix signature motif; other site 869309002816 substrate binding pocket [chemical binding]; other site 869309002817 active site 869309002818 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 869309002819 DNA binding and oxoG recognition site [nucleotide binding] 869309002820 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869309002821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309002822 active site 869309002823 phosphorylation site [posttranslational modification] 869309002824 intermolecular recognition site; other site 869309002825 dimerization interface [polypeptide binding]; other site 869309002826 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869309002827 DNA binding site [nucleotide binding] 869309002828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 869309002829 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 869309002830 putative active site [active] 869309002831 heme pocket [chemical binding]; other site 869309002832 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869309002833 dimer interface [polypeptide binding]; other site 869309002834 phosphorylation site [posttranslational modification] 869309002835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869309002836 ATP binding site [chemical binding]; other site 869309002837 Mg2+ binding site [ion binding]; other site 869309002838 G-X-G motif; other site 869309002839 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 869309002840 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 869309002841 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 869309002842 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 869309002843 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 869309002844 DEAD-like helicases superfamily; Region: DEXDc; smart00487 869309002845 Domain of unknown function (DUF947); Region: DUF947; pfam06102 869309002846 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 869309002847 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 869309002848 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869309002849 NAD binding site [chemical binding]; other site 869309002850 dimer interface [polypeptide binding]; other site 869309002851 substrate binding site [chemical binding]; other site 869309002852 DNA gyrase subunit A; Validated; Region: PRK05560 869309002853 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 869309002854 CAP-like domain; other site 869309002855 active site 869309002856 primary dimer interface [polypeptide binding]; other site 869309002857 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869309002858 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869309002859 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869309002860 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869309002861 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869309002862 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869309002863 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 869309002864 active site 869309002865 catalytic site [active] 869309002866 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 869309002867 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 869309002868 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 869309002869 homodimer interface [polypeptide binding]; other site 869309002870 substrate-cofactor binding pocket; other site 869309002871 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869309002872 catalytic residue [active] 869309002873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 869309002874 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 869309002875 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 869309002876 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 869309002877 RNA binding site [nucleotide binding]; other site 869309002878 active site 869309002879 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 869309002880 Enterocin A Immunity; Region: EntA_Immun; pfam08951 869309002881 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 869309002882 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 869309002883 Sugar specificity; other site 869309002884 Pyrimidine base specificity; other site 869309002885 ATP-binding site [chemical binding]; other site 869309002886 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 869309002887 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 869309002888 generic binding surface II; other site 869309002889 generic binding surface I; other site 869309002890 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 869309002891 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 869309002892 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 869309002893 substrate binding pocket [chemical binding]; other site 869309002894 chain length determination region; other site 869309002895 substrate-Mg2+ binding site; other site 869309002896 catalytic residues [active] 869309002897 aspartate-rich region 1; other site 869309002898 active site lid residues [active] 869309002899 aspartate-rich region 2; other site 869309002900 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 869309002901 S4 RNA-binding domain; Region: S4; smart00363 869309002902 RNA binding surface [nucleotide binding]; other site 869309002903 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 869309002904 Arginine repressor [Transcription]; Region: ArgR; COG1438 869309002905 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869309002906 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869309002907 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 869309002908 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 869309002909 Walker A/P-loop; other site 869309002910 ATP binding site [chemical binding]; other site 869309002911 Q-loop/lid; other site 869309002912 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 869309002913 ABC transporter signature motif; other site 869309002914 Walker B; other site 869309002915 D-loop; other site 869309002916 H-loop/switch region; other site 869309002917 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 869309002918 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 869309002919 active site 869309002920 metal binding site [ion binding]; metal-binding site 869309002921 GTP-binding protein LepA; Provisional; Region: PRK05433 869309002922 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 869309002923 G1 box; other site 869309002924 putative GEF interaction site [polypeptide binding]; other site 869309002925 GTP/Mg2+ binding site [chemical binding]; other site 869309002926 Switch I region; other site 869309002927 G2 box; other site 869309002928 G3 box; other site 869309002929 Switch II region; other site 869309002930 G4 box; other site 869309002931 G5 box; other site 869309002932 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 869309002933 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 869309002934 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 869309002935 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869309002936 active site 869309002937 phosphorylation site [posttranslational modification] 869309002938 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 869309002939 active site 869309002940 P-loop; other site 869309002941 phosphorylation site [posttranslational modification] 869309002942 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 869309002943 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 869309002944 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869309002945 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 869309002946 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 869309002947 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 869309002948 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 869309002949 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869309002950 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869309002951 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869309002952 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 869309002953 G5 domain; Region: G5; pfam07501 869309002954 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869309002955 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 869309002956 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 869309002957 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 869309002958 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 869309002959 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 869309002960 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 869309002961 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 869309002962 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 869309002963 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 869309002964 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 869309002965 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 869309002966 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 869309002967 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869309002968 catalytic residues [active] 869309002969 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 869309002970 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 869309002971 SelR domain; Region: SelR; pfam01641 869309002972 Response regulator receiver domain; Region: Response_reg; pfam00072 869309002973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309002974 active site 869309002975 phosphorylation site [posttranslational modification] 869309002976 intermolecular recognition site; other site 869309002977 dimerization interface [polypeptide binding]; other site 869309002978 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869309002979 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869309002980 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869309002981 Cache domain; Region: Cache_1; pfam02743 869309002982 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869309002983 dimerization interface [polypeptide binding]; other site 869309002984 Histidine kinase; Region: His_kinase; pfam06580 869309002985 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869309002986 ATP binding site [chemical binding]; other site 869309002987 Mg2+ binding site [ion binding]; other site 869309002988 G-X-G motif; other site 869309002989 hypothetical protein; Provisional; Region: PRK13690 869309002991 aminodeoxychorismate synthase; Provisional; Region: PRK07508 869309002992 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 869309002993 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 869309002994 substrate-cofactor binding pocket; other site 869309002995 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 869309002996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869309002997 catalytic residue [active] 869309002998 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 869309003000 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 869309003001 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 869309003002 nucleotide binding site [chemical binding]; other site 869309003003 thymidylate synthase; Reviewed; Region: thyA; PRK01827 869309003004 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 869309003005 dimerization interface [polypeptide binding]; other site 869309003006 active site 869309003007 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 869309003008 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 869309003009 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 869309003010 GTPases [General function prediction only]; Region: HflX; COG2262 869309003011 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 869309003012 HflX GTPase family; Region: HflX; cd01878 869309003013 G1 box; other site 869309003014 GTP/Mg2+ binding site [chemical binding]; other site 869309003015 Switch I region; other site 869309003016 G2 box; other site 869309003017 G3 box; other site 869309003018 Switch II region; other site 869309003019 G4 box; other site 869309003020 G5 box; other site 869309003021 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 869309003022 ribonuclease Z; Region: RNase_Z; TIGR02651 869309003023 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 869309003024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 869309003025 NAD(P) binding site [chemical binding]; other site 869309003026 active site 869309003027 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869309003028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869309003029 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869309003030 dimerization interface [polypeptide binding]; other site 869309003031 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 869309003032 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869309003033 active site residue [active] 869309003034 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869309003035 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 869309003036 RNA binding surface [nucleotide binding]; other site 869309003037 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 869309003038 active site 869309003039 uracil binding [chemical binding]; other site 869309003040 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 869309003041 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 869309003042 G1 box; other site 869309003043 putative GEF interaction site [polypeptide binding]; other site 869309003044 GTP/Mg2+ binding site [chemical binding]; other site 869309003045 Switch I region; other site 869309003046 G2 box; other site 869309003047 G3 box; other site 869309003048 Switch II region; other site 869309003049 G4 box; other site 869309003050 G5 box; other site 869309003051 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 869309003052 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 869309003053 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 869309003055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 869309003056 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 869309003057 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309003058 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869309003059 Walker A/P-loop; other site 869309003060 ATP binding site [chemical binding]; other site 869309003061 Q-loop/lid; other site 869309003062 ABC transporter signature motif; other site 869309003063 Walker B; other site 869309003064 D-loop; other site 869309003065 H-loop/switch region; other site 869309003066 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 869309003067 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 869309003068 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869309003069 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869309003070 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 869309003071 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 869309003072 homodimer interface [polypeptide binding]; other site 869309003073 active site 869309003074 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 869309003075 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 869309003076 Cell division protein FtsQ; Region: FtsQ; pfam03799 869309003077 Peptidase family M50; Region: Peptidase_M50; pfam02163 869309003078 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 869309003079 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 869309003080 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 869309003081 ATP binding site [chemical binding]; other site 869309003082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309003083 Walker B; other site 869309003084 D-loop; other site 869309003085 H-loop/switch region; other site 869309003087 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 869309003088 active site 869309003089 dimer interface [polypeptide binding]; other site 869309003090 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869309003091 active site 869309003093 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869309003094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309003095 Walker A/P-loop; other site 869309003096 ATP binding site [chemical binding]; other site 869309003097 Q-loop/lid; other site 869309003098 ABC transporter signature motif; other site 869309003099 Walker B; other site 869309003100 D-loop; other site 869309003101 H-loop/switch region; other site 869309003103 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 869309003104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309003105 dimer interface [polypeptide binding]; other site 869309003106 conserved gate region; other site 869309003107 putative PBP binding loops; other site 869309003108 ABC-ATPase subunit interface; other site 869309003109 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869309003110 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 869309003111 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 869309003112 dimer interface [polypeptide binding]; other site 869309003113 putative anticodon binding site; other site 869309003114 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 869309003115 motif 1; other site 869309003116 active site 869309003117 motif 2; other site 869309003118 motif 3; other site 869309003119 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 869309003120 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 869309003121 teramer interface [polypeptide binding]; other site 869309003122 active site 869309003123 FMN binding site [chemical binding]; other site 869309003124 catalytic residues [active] 869309003125 Putative transcription activator [Transcription]; Region: TenA; COG0819 869309003127 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 869309003128 substrate binding site [chemical binding]; other site 869309003129 multimerization interface [polypeptide binding]; other site 869309003130 ATP binding site [chemical binding]; other site 869309003131 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 869309003132 thiamine phosphate binding site [chemical binding]; other site 869309003133 active site 869309003134 pyrophosphate binding site [ion binding]; other site 869309003135 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 869309003137 Putative transcription activator [Transcription]; Region: TenA; COG0819 869309003138 Predicted membrane protein [Function unknown]; Region: COG4732 869309003139 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 869309003140 substrate binding site [chemical binding]; other site 869309003141 multimerization interface [polypeptide binding]; other site 869309003142 ATP binding site [chemical binding]; other site 869309003143 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 869309003144 thiamine phosphate binding site [chemical binding]; other site 869309003145 active site 869309003146 pyrophosphate binding site [ion binding]; other site 869309003147 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 869309003148 dimer interface [polypeptide binding]; other site 869309003149 substrate binding site [chemical binding]; other site 869309003150 ATP binding site [chemical binding]; other site 869309003151 Predicted transcriptional regulator [Transcription]; Region: COG3682 869309003152 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 869309003153 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 869309003154 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 869309003155 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 869309003156 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 869309003157 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 869309003158 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 869309003159 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 869309003160 PYR/PP interface [polypeptide binding]; other site 869309003161 dimer interface [polypeptide binding]; other site 869309003162 tetramer interface [polypeptide binding]; other site 869309003163 TPP binding site [chemical binding]; other site 869309003164 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869309003165 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 869309003166 TPP-binding site [chemical binding]; other site 869309003167 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869309003168 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869309003169 active site 869309003171 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 869309003172 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 869309003173 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 869309003176 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 869309003177 putative active site [active] 869309003178 nucleotide binding site [chemical binding]; other site 869309003179 nudix motif; other site 869309003180 putative metal binding site [ion binding]; other site 869309003181 HI0933-like protein; Region: HI0933_like; pfam03486 869309003182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 869309003183 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 869309003184 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869309003185 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869309003186 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 869309003187 catalytic motif [active] 869309003188 Zn binding site [ion binding]; other site 869309003189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869309003190 active site 869309003191 Clp protease; Region: CLP_protease; pfam00574 869309003192 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 869309003193 oligomer interface [polypeptide binding]; other site 869309003194 active site residues [active] 869309003195 hypothetical protein; Provisional; Region: PRK02302 869309003196 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 869309003197 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 869309003198 putative ligand binding site [chemical binding]; other site 869309003199 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869309003200 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 869309003201 TM-ABC transporter signature motif; other site 869309003202 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 869309003203 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 869309003204 TM-ABC transporter signature motif; other site 869309003205 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 869309003206 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 869309003207 Walker A/P-loop; other site 869309003208 ATP binding site [chemical binding]; other site 869309003209 Q-loop/lid; other site 869309003210 ABC transporter signature motif; other site 869309003211 Walker B; other site 869309003212 D-loop; other site 869309003213 H-loop/switch region; other site 869309003214 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 869309003215 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 869309003216 Walker A/P-loop; other site 869309003217 ATP binding site [chemical binding]; other site 869309003218 Q-loop/lid; other site 869309003219 ABC transporter signature motif; other site 869309003220 Walker B; other site 869309003221 D-loop; other site 869309003222 H-loop/switch region; other site 869309003223 FOG: CBS domain [General function prediction only]; Region: COG0517 869309003224 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 869309003225 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 869309003226 PCRF domain; Region: PCRF; pfam03462 869309003227 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 869309003228 RF-1 domain; Region: RF-1; pfam00472 869309003229 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 869309003230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309003231 Walker A/P-loop; other site 869309003232 ATP binding site [chemical binding]; other site 869309003233 Q-loop/lid; other site 869309003234 ABC transporter signature motif; other site 869309003235 Walker B; other site 869309003236 D-loop; other site 869309003237 H-loop/switch region; other site 869309003238 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 869309003239 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 869309003241 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 869309003242 DEAD-like helicases superfamily; Region: DEXDc; smart00487 869309003243 ATP binding site [chemical binding]; other site 869309003244 Mg++ binding site [ion binding]; other site 869309003245 motif III; other site 869309003246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869309003247 nucleotide binding region [chemical binding]; other site 869309003248 ATP-binding site [chemical binding]; other site 869309003249 S-adenosylmethionine synthetase; Validated; Region: PRK05250 869309003250 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 869309003251 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 869309003252 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 869309003253 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 869309003254 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 869309003255 active site 869309003256 FMN binding site [chemical binding]; other site 869309003257 substrate binding site [chemical binding]; other site 869309003258 catalytic residues [active] 869309003259 homodimer interface [polypeptide binding]; other site 869309003260 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 869309003261 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 869309003262 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 869309003263 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 869309003264 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 869309003265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 869309003266 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 869309003267 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869309003268 FeS/SAM binding site; other site 869309003269 VanZ like family; Region: VanZ; pfam04892 869309003270 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869309003271 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869309003272 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869309003273 ABC transporter; Region: ABC_tran_2; pfam12848 869309003274 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869309003275 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 869309003276 active site 869309003277 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 869309003278 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 869309003279 KH domain; Region: KH_4; pfam13083 869309003280 G-X-X-G motif; other site 869309003281 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 869309003282 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 869309003283 RimM N-terminal domain; Region: RimM; pfam01782 869309003284 PRC-barrel domain; Region: PRC; pfam05239 869309003285 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 869309003286 ATP cone domain; Region: ATP-cone; pfam03477 869309003287 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 869309003288 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 869309003290 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 869309003291 HlyD family secretion protein; Region: HlyD_3; pfam13437 869309003292 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869309003293 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869309003294 Walker A/P-loop; other site 869309003295 ATP binding site [chemical binding]; other site 869309003296 Q-loop/lid; other site 869309003297 ABC transporter signature motif; other site 869309003298 Walker B; other site 869309003299 D-loop; other site 869309003300 H-loop/switch region; other site 869309003301 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869309003302 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869309003303 FtsX-like permease family; Region: FtsX; pfam02687 869309003304 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 869309003305 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 869309003306 active site 869309003307 HIGH motif; other site 869309003308 KMSKS motif; other site 869309003309 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 869309003310 tRNA binding surface [nucleotide binding]; other site 869309003311 anticodon binding site; other site 869309003312 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 869309003313 dimer interface [polypeptide binding]; other site 869309003314 putative tRNA-binding site [nucleotide binding]; other site 869309003315 Predicted transcriptional regulators [Transcription]; Region: COG1695 869309003316 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 869309003317 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 869309003318 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 869309003319 active site 869309003320 catalytic tetrad [active] 869309003321 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 869309003322 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 869309003323 classical (c) SDRs; Region: SDR_c; cd05233 869309003324 NAD(P) binding site [chemical binding]; other site 869309003325 active site 869309003326 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 869309003327 nudix motif; other site 869309003328 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 869309003329 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869309003330 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 869309003331 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 869309003332 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 869309003333 Zn binding site [ion binding]; other site 869309003334 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869309003335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309003336 active site 869309003337 phosphorylation site [posttranslational modification] 869309003338 intermolecular recognition site; other site 869309003339 dimerization interface [polypeptide binding]; other site 869309003340 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869309003341 DNA binding site [nucleotide binding] 869309003342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869309003343 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869309003344 dimer interface [polypeptide binding]; other site 869309003345 phosphorylation site [posttranslational modification] 869309003346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869309003347 ATP binding site [chemical binding]; other site 869309003348 Mg2+ binding site [ion binding]; other site 869309003349 G-X-G motif; other site 869309003350 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 869309003351 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 869309003352 Peptidase family U32; Region: Peptidase_U32; pfam01136 869309003353 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 869309003354 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869309003355 active site 869309003356 catalytic site [active] 869309003357 substrate binding site [chemical binding]; other site 869309003358 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869309003359 ATP binding site [chemical binding]; other site 869309003360 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 869309003361 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 869309003362 DJ-1 family protein; Region: not_thiJ; TIGR01383 869309003363 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 869309003364 conserved cys residue [active] 869309003365 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 869309003366 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309003367 motif II; other site 869309003368 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 869309003369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869309003370 Mg2+ binding site [ion binding]; other site 869309003371 G-X-G motif; other site 869309003372 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 869309003373 anchoring element; other site 869309003374 dimer interface [polypeptide binding]; other site 869309003375 ATP binding site [chemical binding]; other site 869309003376 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 869309003377 active site 869309003378 putative metal-binding site [ion binding]; other site 869309003379 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 869309003380 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 869309003383 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 869309003384 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 869309003386 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 869309003387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309003388 Walker A motif; other site 869309003389 ATP binding site [chemical binding]; other site 869309003390 Walker B motif; other site 869309003391 arginine finger; other site 869309003392 UvrB/uvrC motif; Region: UVR; pfam02151 869309003393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309003394 Walker A motif; other site 869309003395 ATP binding site [chemical binding]; other site 869309003396 Walker B motif; other site 869309003397 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869309003398 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 869309003399 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 869309003400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309003401 dimer interface [polypeptide binding]; other site 869309003402 conserved gate region; other site 869309003403 putative PBP binding loops; other site 869309003404 ABC-ATPase subunit interface; other site 869309003405 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869309003406 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 869309003407 Walker A/P-loop; other site 869309003408 ATP binding site [chemical binding]; other site 869309003409 Q-loop/lid; other site 869309003410 ABC transporter signature motif; other site 869309003411 Walker B; other site 869309003412 D-loop; other site 869309003413 H-loop/switch region; other site 869309003414 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 869309003415 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 869309003416 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 869309003417 homodimer interface [polypeptide binding]; other site 869309003418 NADP binding site [chemical binding]; other site 869309003419 substrate binding site [chemical binding]; other site 869309003420 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 869309003421 putative substrate binding site [chemical binding]; other site 869309003422 putative ATP binding site [chemical binding]; other site 869309003423 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 869309003424 tetramer (dimer of dimers) interface [polypeptide binding]; other site 869309003425 active site 869309003426 dimer interface [polypeptide binding]; other site 869309003427 phosphopentomutase; Provisional; Region: PRK05362 869309003428 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 869309003429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 869309003430 purine nucleoside phosphorylase; Provisional; Region: PRK08202 869309003432 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 869309003434 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 869309003435 topology modulation protein; Provisional; Region: PRK07261 869309003436 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 869309003437 active site 869309003438 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 869309003439 pantothenate kinase; Provisional; Region: PRK05439 869309003440 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 869309003441 ATP-binding site [chemical binding]; other site 869309003442 CoA-binding site [chemical binding]; other site 869309003443 Mg2+-binding site [ion binding]; other site 869309003444 Methyltransferase domain; Region: Methyltransf_31; pfam13847 869309003445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309003446 S-adenosylmethionine binding site [chemical binding]; other site 869309003447 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 869309003448 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 869309003449 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 869309003450 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 869309003451 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 869309003452 intersubunit interface [polypeptide binding]; other site 869309003453 active site 869309003454 catalytic residue [active] 869309003455 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 869309003456 active site 869309003457 catalytic motif [active] 869309003458 Zn binding site [ion binding]; other site 869309003459 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 869309003460 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 869309003461 ligand binding site [chemical binding]; other site 869309003462 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 869309003463 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 869309003464 Walker A/P-loop; other site 869309003465 ATP binding site [chemical binding]; other site 869309003466 Q-loop/lid; other site 869309003467 ABC transporter signature motif; other site 869309003468 Walker B; other site 869309003469 D-loop; other site 869309003470 H-loop/switch region; other site 869309003471 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 869309003472 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869309003473 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 869309003474 TM-ABC transporter signature motif; other site 869309003475 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869309003476 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 869309003477 TM-ABC transporter signature motif; other site 869309003479 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 869309003480 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 869309003481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869309003482 Mg2+ binding site [ion binding]; other site 869309003483 G-X-G motif; other site 869309003484 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 869309003485 anchoring element; other site 869309003486 dimer interface [polypeptide binding]; other site 869309003487 ATP binding site [chemical binding]; other site 869309003488 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 869309003489 active site 869309003490 putative metal-binding site [ion binding]; other site 869309003491 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 869309003492 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 869309003493 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 869309003494 CAP-like domain; other site 869309003495 active site 869309003496 primary dimer interface [polypeptide binding]; other site 869309003497 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 869309003498 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 869309003499 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 869309003500 homodimer interface [polypeptide binding]; other site 869309003501 substrate-cofactor binding pocket; other site 869309003502 catalytic residue [active] 869309003503 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 869309003504 Predicted membrane protein [Function unknown]; Region: COG3819 869309003505 Predicted membrane protein [Function unknown]; Region: COG3817 869309003506 Protein of unknown function (DUF979); Region: DUF979; pfam06166 869309003507 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 869309003508 putative substrate binding pocket [chemical binding]; other site 869309003509 AC domain interface; other site 869309003510 catalytic triad [active] 869309003511 AB domain interface; other site 869309003512 interchain disulfide; other site 869309003513 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 869309003514 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 869309003515 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 869309003516 RNA binding site [nucleotide binding]; other site 869309003517 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 869309003518 RNA binding site [nucleotide binding]; other site 869309003519 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 869309003520 RNA binding site [nucleotide binding]; other site 869309003521 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 869309003522 RNA binding site [nucleotide binding]; other site 869309003524 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 869309003525 GAF domain; Region: GAF_2; pfam13185 869309003526 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 869309003527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309003528 Walker A motif; other site 869309003529 ATP binding site [chemical binding]; other site 869309003530 Walker B motif; other site 869309003531 arginine finger; other site 869309003532 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 869309003533 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 869309003534 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 869309003535 Walker A/P-loop; other site 869309003536 ATP binding site [chemical binding]; other site 869309003537 Q-loop/lid; other site 869309003538 ABC transporter signature motif; other site 869309003539 Walker B; other site 869309003540 D-loop; other site 869309003541 H-loop/switch region; other site 869309003542 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 869309003543 FeS assembly protein SufD; Region: sufD; TIGR01981 869309003544 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 869309003545 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 869309003546 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869309003547 catalytic residue [active] 869309003548 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 869309003549 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 869309003550 trimerization site [polypeptide binding]; other site 869309003551 active site 869309003552 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 869309003553 FeS assembly protein SufB; Region: sufB; TIGR01980 869309003554 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 869309003555 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 869309003556 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 869309003557 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 869309003558 Domain of unknown function DUF20; Region: UPF0118; pfam01594 869309003559 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869309003560 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 869309003561 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869309003562 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 869309003563 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 869309003564 putative substrate binding site [chemical binding]; other site 869309003565 putative ATP binding site [chemical binding]; other site 869309003566 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 869309003567 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869309003568 active site 869309003569 phosphorylation site [posttranslational modification] 869309003570 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 869309003571 active site 869309003572 P-loop; other site 869309003573 phosphorylation site [posttranslational modification] 869309003574 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 869309003575 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 869309003576 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 869309003577 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869309003578 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 869309003580 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 869309003581 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 869309003582 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869309003583 catalytic residue [active] 869309003584 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 869309003585 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 869309003586 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 869309003587 Ligand Binding Site [chemical binding]; other site 869309003588 similar to hypothetical protein 869309003589 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 869309003591 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 869309003593 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 869309003594 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 869309003595 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 869309003596 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869309003597 ATP binding site [chemical binding]; other site 869309003598 putative Mg++ binding site [ion binding]; other site 869309003599 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 869309003600 Arginine repressor [Transcription]; Region: ArgR; COG1438 869309003601 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 869309003602 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 869309003603 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 869309003604 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 869309003605 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 869309003606 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 869309003607 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 869309003608 active site 869309003609 PHP Thumb interface [polypeptide binding]; other site 869309003610 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 869309003611 generic binding surface II; other site 869309003612 generic binding surface I; other site 869309003613 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 869309003614 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 869309003615 active site 869309003616 ADP/pyrophosphate binding site [chemical binding]; other site 869309003617 dimerization interface [polypeptide binding]; other site 869309003618 allosteric effector site; other site 869309003619 fructose-1,6-bisphosphate binding site; other site 869309003620 pyruvate kinase; Provisional; Region: PRK05826 869309003621 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 869309003622 domain interfaces; other site 869309003623 active site 869309003625 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 869309003626 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 869309003627 Predicted membrane protein [Function unknown]; Region: COG3689 869309003628 Predicted permeases [General function prediction only]; Region: COG0701 869309003629 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 869309003630 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 869309003631 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 869309003632 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 869309003633 RNA binding site [nucleotide binding]; other site 869309003634 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 869309003635 hypothetical protein; Provisional; Region: PRK04351 869309003636 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 869309003637 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869309003638 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869309003639 Walker A/P-loop; other site 869309003640 ATP binding site [chemical binding]; other site 869309003641 Q-loop/lid; other site 869309003642 ABC transporter signature motif; other site 869309003643 Walker B; other site 869309003644 D-loop; other site 869309003645 H-loop/switch region; other site 869309003646 FtsX-like permease family; Region: FtsX; pfam02687 869309003647 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 869309003648 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 869309003649 Helix-turn-helix domain; Region: HTH_38; pfam13936 869309003650 Integrase core domain; Region: rve; pfam00665 869309003651 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 869309003652 homodimer interface [polypeptide binding]; other site 869309003653 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 869309003654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869309003655 catalytic residue [active] 869309003656 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 869309003658 spermidine synthase; Provisional; Region: PRK00811 869309003659 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309003660 S-adenosylmethionine binding site [chemical binding]; other site 869309003661 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 869309003662 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 869309003663 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 869309003664 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 869309003665 dimer interface [polypeptide binding]; other site 869309003666 active site 869309003667 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 869309003668 catalytic residues [active] 869309003669 substrate binding site [chemical binding]; other site 869309003670 agmatine deiminase; Provisional; Region: PRK13551 869309003671 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 869309003672 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 869309003673 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 869309003674 putative active site; other site 869309003675 catalytic triad [active] 869309003676 putative dimer interface [polypeptide binding]; other site 869309003678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309003679 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 869309003680 active site 869309003681 motif I; other site 869309003682 motif II; other site 869309003683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309003684 CAAX protease self-immunity; Region: Abi; pfam02517 869309003685 Transcriptional regulator [Transcription]; Region: LysR; COG0583 869309003686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 869309003687 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 869309003688 dimerization interface [polypeptide binding]; other site 869309003689 lipoprotein signal peptidase; Provisional; Region: PRK14797 869309003690 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869309003691 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869309003692 RNA binding surface [nucleotide binding]; other site 869309003693 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869309003694 active site 869309003695 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 869309003696 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869309003697 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869309003698 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 869309003699 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 869309003700 nucleotide binding site [chemical binding]; other site 869309003701 homotetrameric interface [polypeptide binding]; other site 869309003702 putative phosphate binding site [ion binding]; other site 869309003703 putative allosteric binding site; other site 869309003704 PUA domain; Region: PUA; pfam01472 869309003705 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 869309003706 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 869309003707 putative catalytic cysteine [active] 869309003708 pyrroline-5-carboxylate reductase; Region: PLN02688 869309003709 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 869309003710 thymidylate kinase; Validated; Region: tmk; PRK00698 869309003711 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 869309003712 TMP-binding site; other site 869309003713 ATP-binding site [chemical binding]; other site 869309003714 DNA polymerase III subunit delta'; Validated; Region: PRK07276 869309003715 DNA polymerase III subunit delta'; Validated; Region: PRK08485 869309003716 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 869309003717 Predicted methyltransferases [General function prediction only]; Region: COG0313 869309003718 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 869309003719 putative SAM binding site [chemical binding]; other site 869309003720 putative homodimer interface [polypeptide binding]; other site 869309003721 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 869309003722 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 869309003724 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 869309003725 Glucose inhibited division protein A; Region: GIDA; pfam01134 869309003726 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 869309003727 putative nucleotide binding site [chemical binding]; other site 869309003728 uridine monophosphate binding site [chemical binding]; other site 869309003729 homohexameric interface [polypeptide binding]; other site 869309003730 ribosome recycling factor; Reviewed; Region: frr; PRK00083 869309003731 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 869309003732 hinge region; other site 869309003733 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 869309003734 S1 domain; Region: S1_2; pfam13509 869309003735 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 869309003736 hypothetical protein; Provisional; Region: PRK13672 869309003737 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 869309003738 PhoH-like protein; Region: PhoH; pfam02562 869309003739 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869309003740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869309003741 Coenzyme A binding pocket [chemical binding]; other site 869309003742 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 869309003743 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 869309003744 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 869309003745 hexamer interface [polypeptide binding]; other site 869309003746 ligand binding site [chemical binding]; other site 869309003747 putative active site [active] 869309003748 NAD(P) binding site [chemical binding]; other site 869309003749 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869309003750 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869309003751 SLBB domain; Region: SLBB; pfam10531 869309003752 comEA protein; Region: comE; TIGR01259 869309003753 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 869309003754 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 869309003755 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 869309003756 Competence protein; Region: Competence; pfam03772 869309003757 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 869309003758 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869309003759 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869309003760 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869309003761 Walker A/P-loop; other site 869309003762 ATP binding site [chemical binding]; other site 869309003763 Q-loop/lid; other site 869309003764 ABC transporter signature motif; other site 869309003765 Walker B; other site 869309003766 D-loop; other site 869309003767 H-loop/switch region; other site 869309003768 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 869309003769 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 869309003770 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 869309003771 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 869309003772 23S rRNA binding site [nucleotide binding]; other site 869309003773 L21 binding site [polypeptide binding]; other site 869309003774 L13 binding site [polypeptide binding]; other site 869309003775 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 869309003776 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 869309003777 dimer interface [polypeptide binding]; other site 869309003778 active site 869309003779 metal binding site [ion binding]; metal-binding site 869309003780 glutathione binding site [chemical binding]; other site 869309003781 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 869309003782 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 869309003783 FAD binding pocket [chemical binding]; other site 869309003784 FAD binding motif [chemical binding]; other site 869309003785 phosphate binding motif [ion binding]; other site 869309003786 beta-alpha-beta structure motif; other site 869309003787 NAD binding pocket [chemical binding]; other site 869309003788 Iron coordination center [ion binding]; other site 869309003789 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 869309003790 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 869309003791 heterodimer interface [polypeptide binding]; other site 869309003792 active site 869309003793 FMN binding site [chemical binding]; other site 869309003794 homodimer interface [polypeptide binding]; other site 869309003795 substrate binding site [chemical binding]; other site 869309003796 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869309003797 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 869309003798 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 869309003799 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 869309003800 Domain of unknown function (DUF814); Region: DUF814; pfam05670 869309003801 metal-binding heat shock protein; Provisional; Region: PRK00016 869309003802 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 869309003803 GTPase Era; Reviewed; Region: era; PRK00089 869309003804 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 869309003805 G1 box; other site 869309003806 GTP/Mg2+ binding site [chemical binding]; other site 869309003807 Switch I region; other site 869309003808 G2 box; other site 869309003809 Switch II region; other site 869309003810 G3 box; other site 869309003811 G4 box; other site 869309003812 G5 box; other site 869309003813 KH domain; Region: KH_2; pfam07650 869309003814 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 869309003815 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 869309003816 DNA binding site [nucleotide binding] 869309003817 catalytic residue [active] 869309003818 H2TH interface [polypeptide binding]; other site 869309003819 putative catalytic residues [active] 869309003820 turnover-facilitating residue; other site 869309003821 intercalation triad [nucleotide binding]; other site 869309003822 8OG recognition residue [nucleotide binding]; other site 869309003823 putative reading head residues; other site 869309003824 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 869309003825 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 869309003826 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 869309003827 dephospho-CoA kinase; Region: TIGR00152 869309003828 CoA-binding site [chemical binding]; other site 869309003829 ATP-binding [chemical binding]; other site 869309003830 drug efflux system protein MdtG; Provisional; Region: PRK09874 869309003831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869309003832 putative substrate translocation pore; other site 869309003833 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 869309003834 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 869309003835 ribonuclease R; Region: RNase_R; TIGR02063 869309003836 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 869309003837 RNB domain; Region: RNB; pfam00773 869309003838 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 869309003839 RNA binding site [nucleotide binding]; other site 869309003840 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 869309003841 SmpB-tmRNA interface; other site 869309003842 tellurite resistance protein TehB; Provisional; Region: PRK12335 869309003843 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 869309003844 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309003845 S-adenosylmethionine binding site [chemical binding]; other site 869309003846 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 869309003847 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 869309003848 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 869309003849 active site 869309003850 Zn binding site [ion binding]; other site 869309003851 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 869309003852 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309003853 S-adenosylmethionine binding site [chemical binding]; other site 869309003854 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 869309003855 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 869309003857 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869309003858 catalytic core [active] 869309003859 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 869309003860 putative deacylase active site [active] 869309003861 Predicted membrane protein [Function unknown]; Region: COG2035 869309003862 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 869309003863 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 869309003864 active site 869309003865 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 869309003866 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 869309003867 Substrate binding site; other site 869309003868 Mg++ binding site; other site 869309003869 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 869309003870 active site 869309003871 substrate binding site [chemical binding]; other site 869309003872 CoA binding site [chemical binding]; other site 869309003873 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 869309003874 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 869309003875 dimer interface [polypeptide binding]; other site 869309003876 ADP-ribose binding site [chemical binding]; other site 869309003877 active site 869309003878 nudix motif; other site 869309003879 metal binding site [ion binding]; metal-binding site 869309003880 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 869309003881 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 869309003882 MarR family; Region: MarR_2; cl17246 869309003883 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 869309003884 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869309003885 active site 869309003886 catalytic site [active] 869309003887 substrate binding site [chemical binding]; other site 869309003888 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 869309003889 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 869309003890 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 869309003891 putative active site [active] 869309003892 catalytic site [active] 869309003893 putative metal binding site [ion binding]; other site 869309003894 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 869309003896 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 869309003897 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 869309003898 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 869309003899 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 869309003900 catalytic residues [active] 869309003901 amino acid transporter; Region: 2A0306; TIGR00909 869309003902 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 869309003903 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869309003904 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 869309003905 metal binding site [ion binding]; metal-binding site 869309003906 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 869309003907 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869309003908 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869309003909 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869309003910 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 869309003911 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869309003912 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 869309003914 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 869309003915 peptidase T; Region: peptidase-T; TIGR01882 869309003916 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 869309003917 metal binding site [ion binding]; metal-binding site 869309003918 dimer interface [polypeptide binding]; other site 869309003919 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 869309003920 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 869309003921 C-terminal domain interface [polypeptide binding]; other site 869309003922 active site 869309003923 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 869309003924 active site 869309003925 N-terminal domain interface [polypeptide binding]; other site 869309003926 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 869309003927 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 869309003928 Predicted membrane protein [Function unknown]; Region: COG2246 869309003929 GtrA-like protein; Region: GtrA; pfam04138 869309003930 Predicted membrane protein [Function unknown]; Region: COG4708 869309003931 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 869309003932 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 869309003933 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 869309003934 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 869309003935 dimer interface [polypeptide binding]; other site 869309003936 active site 869309003937 catalytic residue [active] 869309003938 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 869309003939 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 869309003940 trmE is a tRNA modification GTPase; Region: trmE; cd04164 869309003941 G1 box; other site 869309003942 GTP/Mg2+ binding site [chemical binding]; other site 869309003943 Switch I region; other site 869309003944 G2 box; other site 869309003945 Switch II region; other site 869309003946 G3 box; other site 869309003947 G4 box; other site 869309003948 G5 box; other site 869309003949 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 869309003950 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 869309003951 active site 1 [active] 869309003952 dimer interface [polypeptide binding]; other site 869309003953 hexamer interface [polypeptide binding]; other site 869309003954 active site 2 [active] 869309003955 thymidine kinase; Provisional; Region: PRK04296 869309003956 peptide chain release factor 1; Validated; Region: prfA; PRK00591 869309003957 This domain is found in peptide chain release factors; Region: PCRF; smart00937 869309003958 RF-1 domain; Region: RF-1; pfam00472 869309003959 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 869309003960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309003961 S-adenosylmethionine binding site [chemical binding]; other site 869309003962 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 869309003963 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869309003964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869309003965 Coenzyme A binding pocket [chemical binding]; other site 869309003966 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 869309003967 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 869309003968 dimer interface [polypeptide binding]; other site 869309003969 active site 869309003970 glycine-pyridoxal phosphate binding site [chemical binding]; other site 869309003971 folate binding site [chemical binding]; other site 869309003972 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 869309003973 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 869309003974 Lysozyme-like; Region: Lysozyme_like; pfam13702 869309003975 Predicted secreted protein [Function unknown]; Region: COG4086 869309003976 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 869309003977 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 869309003978 TRAM domain; Region: TRAM; cl01282 869309003979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309003980 S-adenosylmethionine binding site [chemical binding]; other site 869309003981 Predicted transcriptional regulator [Transcription]; Region: COG3655 869309003982 sequence-specific DNA binding site [nucleotide binding]; other site 869309003983 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 869309003984 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 869309003985 siderophore binding site; other site 869309003986 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 869309003987 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869309003988 ABC-ATPase subunit interface; other site 869309003989 dimer interface [polypeptide binding]; other site 869309003990 putative PBP binding regions; other site 869309003991 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869309003992 ABC-ATPase subunit interface; other site 869309003993 dimer interface [polypeptide binding]; other site 869309003994 putative PBP binding regions; other site 869309003995 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869309003996 ABC-ATPase subunit interface; other site 869309003997 dimer interface [polypeptide binding]; other site 869309003998 putative PBP binding regions; other site 869309003999 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 869309004000 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 869309004001 Walker A/P-loop; other site 869309004002 ATP binding site [chemical binding]; other site 869309004003 Q-loop/lid; other site 869309004004 ABC transporter signature motif; other site 869309004005 Walker B; other site 869309004006 D-loop; other site 869309004007 H-loop/switch region; other site 869309004008 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 869309004010 MobA/MobL family; Region: MobA_MobL; pfam03389 869309004011 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 869309004012 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 869309004013 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 869309004014 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 869309004015 catalytic residues [active] 869309004016 Recombinase; Region: Recombinase; pfam07508 869309004017 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 869309004018 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 869309004019 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 869309004020 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 869309004021 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 869309004022 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 869309004023 homodimer interface [polypeptide binding]; other site 869309004024 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 869309004025 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 869309004026 active site 869309004027 homodimer interface [polypeptide binding]; other site 869309004028 catalytic site [active] 869309004029 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869309004030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309004031 non-specific DNA binding site [nucleotide binding]; other site 869309004032 salt bridge; other site 869309004033 sequence-specific DNA binding site [nucleotide binding]; other site 869309004034 Zeta toxin; Region: Zeta_toxin; pfam06414 869309004035 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 869309004038 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869309004039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309004040 non-specific DNA binding site [nucleotide binding]; other site 869309004041 salt bridge; other site 869309004042 sequence-specific DNA binding site [nucleotide binding]; other site 869309004043 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869309004044 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 869309004045 active site 869309004046 zinc binding site [ion binding]; other site 869309004047 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 869309004048 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 869309004049 putative active site [active] 869309004050 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869309004051 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309004052 Walker A/P-loop; other site 869309004053 ATP binding site [chemical binding]; other site 869309004054 Q-loop/lid; other site 869309004055 ABC transporter signature motif; other site 869309004056 Walker B; other site 869309004057 D-loop; other site 869309004058 H-loop/switch region; other site 869309004059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309004060 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 869309004061 Walker A/P-loop; other site 869309004062 ATP binding site [chemical binding]; other site 869309004063 Q-loop/lid; other site 869309004064 ABC transporter signature motif; other site 869309004065 Walker B; other site 869309004066 D-loop; other site 869309004067 H-loop/switch region; other site 869309004068 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 869309004069 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869309004070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309004071 non-specific DNA binding site [nucleotide binding]; other site 869309004072 salt bridge; other site 869309004073 sequence-specific DNA binding site [nucleotide binding]; other site 869309004074 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 869309004075 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 869309004076 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 869309004077 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 869309004078 zinc binding site [ion binding]; other site 869309004079 putative ligand binding site [chemical binding]; other site 869309004080 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 869309004081 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 869309004082 TM-ABC transporter signature motif; other site 869309004083 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 869309004084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309004085 Walker A/P-loop; other site 869309004086 ATP binding site [chemical binding]; other site 869309004087 Q-loop/lid; other site 869309004088 ABC transporter signature motif; other site 869309004089 Walker B; other site 869309004090 D-loop; other site 869309004091 H-loop/switch region; other site 869309004092 DNA primase; Validated; Region: dnaG; PRK05667 869309004093 CHC2 zinc finger; Region: zf-CHC2; pfam01807 869309004094 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 869309004095 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 869309004096 active site 869309004097 metal binding site [ion binding]; metal-binding site 869309004098 interdomain interaction site; other site 869309004099 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 869309004100 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 869309004101 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 869309004102 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 869309004103 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 869309004104 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 869309004105 DNA binding residues [nucleotide binding] 869309004106 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 869309004107 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869309004108 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 869309004109 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 869309004110 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 869309004111 putative ADP-binding pocket [chemical binding]; other site 869309004112 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 869309004113 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 869309004114 GTPase CgtA; Reviewed; Region: obgE; PRK12297 869309004115 GTP1/OBG; Region: GTP1_OBG; pfam01018 869309004116 Obg GTPase; Region: Obg; cd01898 869309004117 G1 box; other site 869309004118 GTP/Mg2+ binding site [chemical binding]; other site 869309004119 Switch I region; other site 869309004120 G2 box; other site 869309004121 G3 box; other site 869309004122 Switch II region; other site 869309004123 G4 box; other site 869309004124 G5 box; other site 869309004125 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 869309004126 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 869309004127 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 869309004128 hinge; other site 869309004129 active site 869309004130 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869309004131 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 869309004132 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 869309004133 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869309004134 DNA-binding site [nucleotide binding]; DNA binding site 869309004135 DRTGG domain; Region: DRTGG; pfam07085 869309004136 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 869309004137 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 869309004138 active site 2 [active] 869309004139 active site 1 [active] 869309004140 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 869309004141 active site 869309004143 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 869309004144 Part of AAA domain; Region: AAA_19; pfam13245 869309004145 Family description; Region: UvrD_C_2; pfam13538 869309004146 hypothetical protein; Reviewed; Region: PRK00024 869309004147 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 869309004148 MPN+ (JAMM) motif; other site 869309004149 Zinc-binding site [ion binding]; other site 869309004150 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 869309004151 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 869309004152 catalytic triad [active] 869309004153 CoA binding domain; Region: CoA_binding; pfam02629 869309004154 Putative amino acid metabolism; Region: DUF1831; pfam08866 869309004155 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 869309004156 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 869309004157 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 869309004158 catalytic residue [active] 869309004159 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 869309004160 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 869309004161 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869309004162 active site 869309004163 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 869309004164 putative active site [active] 869309004165 putative metal binding residues [ion binding]; other site 869309004166 signature motif; other site 869309004167 putative triphosphate binding site [ion binding]; other site 869309004168 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 869309004169 synthetase active site [active] 869309004170 NTP binding site [chemical binding]; other site 869309004171 metal binding site [ion binding]; metal-binding site 869309004172 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 869309004173 ATP-NAD kinase; Region: NAD_kinase; pfam01513 869309004174 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 869309004175 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 869309004176 RNA binding surface [nucleotide binding]; other site 869309004177 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 869309004178 active site 869309004179 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 869309004181 hypothetical protein; Validated; Region: PRK00153 869309004183 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 869309004184 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 869309004185 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 869309004187 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 869309004188 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 869309004189 active site 869309004190 Riboflavin kinase; Region: Flavokinase; smart00904 869309004191 Uncharacterized conserved protein [Function unknown]; Region: COG1284 869309004192 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869309004193 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 869309004194 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 869309004195 EDD domain protein, DegV family; Region: DegV; TIGR00762 869309004196 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 869309004197 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 869309004198 IHF dimer interface [polypeptide binding]; other site 869309004199 IHF - DNA interface [nucleotide binding]; other site 869309004200 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 869309004201 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869309004202 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869309004203 ABC transporter; Region: ABC_tran_2; pfam12848 869309004204 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869309004205 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309004206 non-specific DNA binding site [nucleotide binding]; other site 869309004207 salt bridge; other site 869309004208 sequence-specific DNA binding site [nucleotide binding]; other site 869309004209 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869309004210 H+ Antiporter protein; Region: 2A0121; TIGR00900 869309004211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869309004212 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 869309004213 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 869309004214 nucleotide binding pocket [chemical binding]; other site 869309004215 K-X-D-G motif; other site 869309004216 catalytic site [active] 869309004217 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 869309004218 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 869309004219 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 869309004220 Dimer interface [polypeptide binding]; other site 869309004221 BRCT sequence motif; other site 869309004222 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 869309004223 pullulanase, type I; Region: pulA_typeI; TIGR02104 869309004224 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 869309004225 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 869309004226 Ca binding site [ion binding]; other site 869309004227 active site 869309004228 catalytic site [active] 869309004229 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 869309004230 activator binding site; other site 869309004231 tetrameric interface [polypeptide binding]; other site 869309004232 NADP binding site [chemical binding]; other site 869309004233 substrate binding site [chemical binding]; other site 869309004234 catalytic residues [active] 869309004235 glycogen branching enzyme; Provisional; Region: PRK12313 869309004236 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 869309004237 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 869309004238 active site 869309004239 catalytic site [active] 869309004240 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 869309004241 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 869309004242 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 869309004243 ligand binding site; other site 869309004244 oligomer interface; other site 869309004245 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 869309004246 dimer interface [polypeptide binding]; other site 869309004247 N-terminal domain interface [polypeptide binding]; other site 869309004248 sulfate 1 binding site; other site 869309004249 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 869309004250 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 869309004251 active site 869309004252 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 869309004253 dimer interface [polypeptide binding]; other site 869309004254 N-terminal domain interface [polypeptide binding]; other site 869309004255 sulfate 1 binding site; other site 869309004256 glycogen synthase; Provisional; Region: glgA; PRK00654 869309004257 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 869309004258 ADP-binding pocket [chemical binding]; other site 869309004259 homodimer interface [polypeptide binding]; other site 869309004260 phosphoserine phosphatase SerB; Region: serB; TIGR00338 869309004261 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 869309004262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309004263 motif II; other site 869309004264 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 869309004265 Uncharacterized conserved protein [Function unknown]; Region: COG5506 869309004266 enolase; Provisional; Region: eno; PRK00077 869309004267 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 869309004268 dimer interface [polypeptide binding]; other site 869309004269 metal binding site [ion binding]; metal-binding site 869309004270 substrate binding pocket [chemical binding]; other site 869309004271 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869309004272 DNA binding site [nucleotide binding] 869309004273 active site 869309004274 Int/Topo IB signature motif; other site 869309004276 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 869309004277 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 869309004278 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 869309004279 Part of AAA domain; Region: AAA_19; pfam13245 869309004280 Family description; Region: UvrD_C_2; pfam13538 869309004281 Family description; Region: UvrD_C_2; pfam13538 869309004282 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 869309004284 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 869309004285 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 869309004286 GTP/Mg2+ binding site [chemical binding]; other site 869309004287 G4 box; other site 869309004288 G5 box; other site 869309004289 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 869309004290 G1 box; other site 869309004291 G1 box; other site 869309004292 GTP/Mg2+ binding site [chemical binding]; other site 869309004293 Switch I region; other site 869309004294 G2 box; other site 869309004295 G2 box; other site 869309004296 G3 box; other site 869309004297 G3 box; other site 869309004298 Switch II region; other site 869309004299 Switch II region; other site 869309004300 G5 box; other site 869309004301 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 869309004302 RNA/DNA hybrid binding site [nucleotide binding]; other site 869309004303 active site 869309004304 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 869309004305 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 869309004306 Cl- selectivity filter; other site 869309004307 Cl- binding residues [ion binding]; other site 869309004308 pore gating glutamate residue; other site 869309004309 dimer interface [polypeptide binding]; other site 869309004310 H+/Cl- coupling transport residue; other site 869309004311 TrkA-C domain; Region: TrkA_C; pfam02080 869309004312 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 869309004313 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 869309004314 active site 869309004315 DNA binding site [nucleotide binding] 869309004316 Int/Topo IB signature motif; other site 869309004317 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 869309004318 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 869309004319 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 869309004320 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 869309004321 E3 interaction surface; other site 869309004322 lipoyl attachment site [posttranslational modification]; other site 869309004323 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 869309004324 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 869309004325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 869309004326 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 869309004327 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 869309004328 e3 binding domain; Region: E3_binding; pfam02817 869309004329 e3 binding domain; Region: E3_binding; pfam02817 869309004330 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 869309004331 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 869309004332 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 869309004333 alpha subunit interface [polypeptide binding]; other site 869309004334 TPP binding site [chemical binding]; other site 869309004335 heterodimer interface [polypeptide binding]; other site 869309004336 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 869309004337 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 869309004338 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 869309004339 tetramer interface [polypeptide binding]; other site 869309004340 TPP-binding site [chemical binding]; other site 869309004341 heterodimer interface [polypeptide binding]; other site 869309004342 phosphorylation loop region [posttranslational modification] 869309004343 multidrug efflux protein; Reviewed; Region: PRK01766 869309004344 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 869309004345 cation binding site [ion binding]; other site 869309004346 dihydroorotase; Validated; Region: pyrC; PRK09357 869309004347 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 869309004348 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 869309004349 active site 869309004350 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 869309004351 putative active site [active] 869309004352 nucleotide binding site [chemical binding]; other site 869309004353 nudix motif; other site 869309004354 putative metal binding site [ion binding]; other site 869309004355 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 869309004356 ligand binding site [chemical binding]; other site 869309004357 active site 869309004358 UGI interface [polypeptide binding]; other site 869309004359 catalytic site [active] 869309004360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309004361 motif II; other site 869309004362 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 869309004364 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 869309004365 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 869309004366 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 869309004367 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 869309004368 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 869309004369 dimerization domain swap beta strand [polypeptide binding]; other site 869309004370 regulatory protein interface [polypeptide binding]; other site 869309004371 active site 869309004372 regulatory phosphorylation site [posttranslational modification]; other site 869309004373 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 869309004374 catalytic residues [active] 869309004376 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869309004377 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 869309004378 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869309004379 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 869309004380 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 869309004381 beta-galactosidase; Region: BGL; TIGR03356 869309004383 CAT RNA binding domain; Region: CAT_RBD; smart01061 869309004384 transcriptional antiterminator BglG; Provisional; Region: PRK09772 869309004385 PRD domain; Region: PRD; pfam00874 869309004386 PRD domain; Region: PRD; pfam00874 869309004387 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 869309004388 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 869309004389 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 869309004390 putative substrate binding site [chemical binding]; other site 869309004391 putative ATP binding site [chemical binding]; other site 869309004392 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 869309004393 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 869309004394 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 869309004395 catalytic residues [active] 869309004397 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 869309004398 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869309004399 active site 869309004400 phosphorylation site [posttranslational modification] 869309004402 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 869309004405 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 869309004406 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 869309004407 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 869309004408 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 869309004409 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 869309004410 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309004411 Walker A/P-loop; other site 869309004412 ATP binding site [chemical binding]; other site 869309004413 Q-loop/lid; other site 869309004414 ABC transporter signature motif; other site 869309004415 Walker B; other site 869309004416 D-loop; other site 869309004417 H-loop/switch region; other site 869309004418 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 869309004419 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 869309004420 mRNA/rRNA interface [nucleotide binding]; other site 869309004421 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 869309004422 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 869309004423 23S rRNA interface [nucleotide binding]; other site 869309004424 L7/L12 interface [polypeptide binding]; other site 869309004425 putative thiostrepton binding site; other site 869309004426 L25 interface [polypeptide binding]; other site 869309004427 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 869309004428 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 869309004431 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 869309004432 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 869309004433 putative oligomer interface [polypeptide binding]; other site 869309004434 putative active site [active] 869309004435 metal binding site [ion binding]; metal-binding site 869309004436 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 869309004437 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869309004438 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 869309004439 putative uracil binding site [chemical binding]; other site 869309004440 putative active site [active] 869309004441 dipeptidase PepV; Reviewed; Region: PRK07318 869309004442 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 869309004443 active site 869309004444 metal binding site [ion binding]; metal-binding site 869309004447 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 869309004448 active site 869309004449 metal binding site [ion binding]; metal-binding site 869309004450 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 869309004451 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 869309004452 GIY-YIG motif/motif A; other site 869309004453 active site 869309004454 catalytic site [active] 869309004455 putative DNA binding site [nucleotide binding]; other site 869309004456 metal binding site [ion binding]; metal-binding site 869309004457 UvrB/uvrC motif; Region: UVR; pfam02151 869309004458 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 869309004459 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 869309004460 active site 869309004461 FemAB family; Region: FemAB; pfam02388 869309004462 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 869309004463 Predicted esterase [General function prediction only]; Region: COG0627 869309004464 S-formylglutathione hydrolase; Region: PLN02442 869309004465 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 869309004466 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 869309004467 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 869309004468 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 869309004469 DHH family; Region: DHH; pfam01368 869309004470 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 869309004472 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869309004473 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869309004474 substrate binding pocket [chemical binding]; other site 869309004475 membrane-bound complex binding site; other site 869309004476 hinge residues; other site 869309004478 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 869309004479 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 869309004480 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 869309004481 FAD binding pocket [chemical binding]; other site 869309004482 FAD binding motif [chemical binding]; other site 869309004483 phosphate binding motif [ion binding]; other site 869309004484 beta-alpha-beta structure motif; other site 869309004485 NAD binding pocket [chemical binding]; other site 869309004486 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 869309004487 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 869309004488 intersubunit interface [polypeptide binding]; other site 869309004489 active site 869309004490 zinc binding site [ion binding]; other site 869309004491 Na+ binding site [ion binding]; other site 869309004492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869309004493 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869309004494 dimerization interface [polypeptide binding]; other site 869309004495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869309004496 dimer interface [polypeptide binding]; other site 869309004497 phosphorylation site [posttranslational modification] 869309004498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869309004499 ATP binding site [chemical binding]; other site 869309004500 Mg2+ binding site [ion binding]; other site 869309004501 G-X-G motif; other site 869309004502 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869309004503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309004504 active site 869309004505 phosphorylation site [posttranslational modification] 869309004506 intermolecular recognition site; other site 869309004507 dimerization interface [polypeptide binding]; other site 869309004508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869309004509 DNA binding site [nucleotide binding] 869309004510 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869309004511 FtsX-like permease family; Region: FtsX; pfam02687 869309004512 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869309004513 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869309004514 Walker A/P-loop; other site 869309004515 ATP binding site [chemical binding]; other site 869309004516 Q-loop/lid; other site 869309004517 ABC transporter signature motif; other site 869309004518 Walker B; other site 869309004519 D-loop; other site 869309004520 H-loop/switch region; other site 869309004521 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 869309004522 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 869309004523 FtsX-like permease family; Region: FtsX; pfam02687 869309004524 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 869309004525 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 869309004526 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 869309004527 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 869309004528 dimerization interface [polypeptide binding]; other site 869309004529 metal binding site [ion binding]; metal-binding site 869309004530 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 869309004531 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869309004532 active site 869309004533 HIGH motif; other site 869309004534 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 869309004535 KMSKS motif; other site 869309004536 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 869309004537 tRNA binding surface [nucleotide binding]; other site 869309004538 anticodon binding site; other site 869309004539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869309004540 Coenzyme A binding pocket [chemical binding]; other site 869309004541 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869309004542 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869309004543 Coenzyme A binding pocket [chemical binding]; other site 869309004544 serine O-acetyltransferase; Region: cysE; TIGR01172 869309004545 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 869309004546 trimer interface [polypeptide binding]; other site 869309004547 active site 869309004548 substrate binding site [chemical binding]; other site 869309004549 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 869309004550 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 869309004551 RNase E interface [polypeptide binding]; other site 869309004552 trimer interface [polypeptide binding]; other site 869309004553 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 869309004554 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 869309004555 RNase E interface [polypeptide binding]; other site 869309004556 trimer interface [polypeptide binding]; other site 869309004557 active site 869309004558 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 869309004559 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 869309004560 RNA binding site [nucleotide binding]; other site 869309004561 domain interface; other site 869309004562 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 869309004563 FAD binding site [chemical binding]; other site 869309004564 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 869309004565 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 869309004566 THF binding site; other site 869309004567 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 869309004568 substrate binding site [chemical binding]; other site 869309004569 THF binding site; other site 869309004570 zinc-binding site [ion binding]; other site 869309004571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309004572 non-specific DNA binding site [nucleotide binding]; other site 869309004573 salt bridge; other site 869309004574 sequence-specific DNA binding site [nucleotide binding]; other site 869309004576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309004577 non-specific DNA binding site [nucleotide binding]; other site 869309004578 salt bridge; other site 869309004579 sequence-specific DNA binding site [nucleotide binding]; other site 869309004580 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 869309004581 putative catalytic site [active] 869309004582 putative metal binding site [ion binding]; other site 869309004583 putative phosphate binding site [ion binding]; other site 869309004585 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 869309004586 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 869309004587 putative tRNA-binding site [nucleotide binding]; other site 869309004588 B3/4 domain; Region: B3_4; pfam03483 869309004589 tRNA synthetase B5 domain; Region: B5; smart00874 869309004590 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 869309004591 dimer interface [polypeptide binding]; other site 869309004592 motif 1; other site 869309004593 motif 3; other site 869309004594 motif 2; other site 869309004595 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 869309004596 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 869309004597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869309004598 Coenzyme A binding pocket [chemical binding]; other site 869309004599 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 869309004600 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 869309004601 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 869309004602 dimer interface [polypeptide binding]; other site 869309004603 motif 1; other site 869309004604 active site 869309004605 motif 2; other site 869309004606 motif 3; other site 869309004607 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 869309004608 beta-galactosidase; Region: BGL; TIGR03356 869309004609 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 869309004610 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 869309004611 active site turn [active] 869309004612 phosphorylation site [posttranslational modification] 869309004613 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 869309004614 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 869309004615 HPr interaction site; other site 869309004616 glycerol kinase (GK) interaction site [polypeptide binding]; other site 869309004617 active site 869309004618 phosphorylation site [posttranslational modification] 869309004619 transcriptional antiterminator BglG; Provisional; Region: PRK09772 869309004620 CAT RNA binding domain; Region: CAT_RBD; smart01061 869309004621 PRD domain; Region: PRD; pfam00874 869309004622 PRD domain; Region: PRD; pfam00874 869309004625 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 869309004626 Fic/DOC family; Region: Fic; pfam02661 869309004627 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 869309004628 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 869309004629 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869309004630 active site 869309004631 HIGH motif; other site 869309004632 nucleotide binding site [chemical binding]; other site 869309004633 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869309004634 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 869309004635 active site 869309004636 KMSKS motif; other site 869309004637 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 869309004638 tRNA binding surface [nucleotide binding]; other site 869309004639 anticodon binding site; other site 869309004640 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 869309004641 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 869309004642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869309004643 Coenzyme A binding pocket [chemical binding]; other site 869309004644 Flavin Reductases; Region: FlaRed; cl00801 869309004645 hypothetical protein; Provisional; Region: PRK07758 869309004646 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 869309004647 Uncharacterized conserved protein [Function unknown]; Region: COG2461 869309004648 Family of unknown function (DUF438); Region: DUF438; pfam04282 869309004649 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 869309004650 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 869309004651 putative active site [active] 869309004652 heme pocket [chemical binding]; other site 869309004653 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 869309004655 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 869309004656 translation initiation factor IF-2; Region: IF-2; TIGR00487 869309004657 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 869309004658 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 869309004659 G1 box; other site 869309004660 putative GEF interaction site [polypeptide binding]; other site 869309004661 GTP/Mg2+ binding site [chemical binding]; other site 869309004662 Switch I region; other site 869309004663 G2 box; other site 869309004664 G3 box; other site 869309004665 Switch II region; other site 869309004666 G4 box; other site 869309004667 G5 box; other site 869309004668 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 869309004669 Translation-initiation factor 2; Region: IF-2; pfam11987 869309004670 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 869309004671 hypothetical protein; Provisional; Region: PRK07283 869309004672 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 869309004673 putative RNA binding cleft [nucleotide binding]; other site 869309004674 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 869309004675 NusA N-terminal domain; Region: NusA_N; pfam08529 869309004676 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 869309004677 RNA binding site [nucleotide binding]; other site 869309004678 homodimer interface [polypeptide binding]; other site 869309004679 NusA-like KH domain; Region: KH_5; pfam13184 869309004680 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 869309004681 G-X-X-G motif; other site 869309004682 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 869309004683 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 869309004684 putative oligomer interface [polypeptide binding]; other site 869309004685 putative RNA binding site [nucleotide binding]; other site 869309004686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 869309004687 S-adenosylmethionine binding site [chemical binding]; other site 869309004688 Phosphotransferase enzyme family; Region: APH; pfam01636 869309004689 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 869309004690 substrate binding site [chemical binding]; other site 869309004691 CAAX protease self-immunity; Region: Abi; pfam02517 869309004692 CAAX protease self-immunity; Region: Abi; pfam02517 869309004693 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 869309004694 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 869309004695 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 869309004696 putative active site [active] 869309004697 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869309004698 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309004699 Walker A/P-loop; other site 869309004700 ATP binding site [chemical binding]; other site 869309004701 Q-loop/lid; other site 869309004702 ABC transporter signature motif; other site 869309004703 Walker B; other site 869309004704 D-loop; other site 869309004705 H-loop/switch region; other site 869309004706 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 869309004707 HlyD family secretion protein; Region: HlyD_3; pfam13437 869309004708 COMC family; Region: ComC; pfam03047 869309004709 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869309004710 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 869309004711 ATP binding site [chemical binding]; other site 869309004712 Mg2+ binding site [ion binding]; other site 869309004713 G-X-G motif; other site 869309004714 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869309004715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309004716 active site 869309004717 phosphorylation site [posttranslational modification] 869309004718 intermolecular recognition site; other site 869309004719 dimerization interface [polypeptide binding]; other site 869309004720 LytTr DNA-binding domain; Region: LytTR; pfam04397 869309004721 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869309004722 LytTr DNA-binding domain; Region: LytTR; pfam04397 869309004724 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 869309004725 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 869309004726 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 869309004727 Walker A/P-loop; other site 869309004728 ATP binding site [chemical binding]; other site 869309004729 Q-loop/lid; other site 869309004730 ABC transporter signature motif; other site 869309004731 Walker B; other site 869309004732 D-loop; other site 869309004733 H-loop/switch region; other site 869309004734 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 869309004735 HIT family signature motif; other site 869309004736 catalytic residue [active] 869309004737 chaperone protein DnaJ; Provisional; Region: PRK14276 869309004738 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 869309004739 HSP70 interaction site [polypeptide binding]; other site 869309004740 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 869309004741 substrate binding site [polypeptide binding]; other site 869309004742 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 869309004743 Zn binding sites [ion binding]; other site 869309004744 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 869309004745 substrate binding site [polypeptide binding]; other site 869309004746 dimer interface [polypeptide binding]; other site 869309004747 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 869309004748 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 869309004749 nucleotide binding site [chemical binding]; other site 869309004750 NEF interaction site [polypeptide binding]; other site 869309004751 SBD interface [polypeptide binding]; other site 869309004752 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 869309004753 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 869309004754 dimer interface [polypeptide binding]; other site 869309004755 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 869309004756 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 869309004757 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 869309004758 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 869309004759 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 869309004760 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 869309004761 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 869309004762 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 869309004763 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 869309004764 DNA binding residues [nucleotide binding] 869309004765 putative dimer interface [polypeptide binding]; other site 869309004766 Predicted membrane protein [Function unknown]; Region: COG4129 869309004767 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 869309004768 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 869309004769 Phosphoglycerate kinase; Region: PGK; pfam00162 869309004770 substrate binding site [chemical binding]; other site 869309004771 hinge regions; other site 869309004772 ADP binding site [chemical binding]; other site 869309004773 catalytic site [active] 869309004774 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869309004775 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 869309004776 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 869309004777 putative active site [active] 869309004778 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869309004779 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 869309004780 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 869309004781 G5 domain; Region: G5; pfam07501 869309004782 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 869309004783 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 869309004784 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 869309004785 PhoU domain; Region: PhoU; pfam01895 869309004786 PhoU domain; Region: PhoU; pfam01895 869309004787 CTP synthetase; Validated; Region: pyrG; PRK05380 869309004788 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 869309004789 Catalytic site [active] 869309004790 active site 869309004791 UTP binding site [chemical binding]; other site 869309004792 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 869309004793 active site 869309004794 putative oxyanion hole; other site 869309004795 catalytic triad [active] 869309004796 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 869309004798 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 869309004799 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 869309004800 active site 869309004801 Predicted membrane protein [Function unknown]; Region: COG3601 869309004802 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 869309004803 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 869309004804 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869309004805 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869309004806 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869309004807 Walker A/P-loop; other site 869309004808 ATP binding site [chemical binding]; other site 869309004809 Q-loop/lid; other site 869309004810 ABC transporter signature motif; other site 869309004811 Walker B; other site 869309004812 D-loop; other site 869309004813 H-loop/switch region; other site 869309004814 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 869309004815 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869309004816 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869309004817 Walker A/P-loop; other site 869309004818 ATP binding site [chemical binding]; other site 869309004819 Q-loop/lid; other site 869309004820 ABC transporter signature motif; other site 869309004821 Walker B; other site 869309004822 D-loop; other site 869309004823 H-loop/switch region; other site 869309004824 hypothetical protein; Provisional; Region: PRK13661 869309004825 Uncharacterized conserved protein [Function unknown]; Region: COG1912 869309004826 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 869309004827 TrkA-N domain; Region: TrkA_N; pfam02254 869309004828 TrkA-C domain; Region: TrkA_C; pfam02080 869309004829 TrkA-N domain; Region: TrkA_N; pfam02254 869309004830 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 869309004831 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 869309004832 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 869309004833 active site 869309004834 P-loop; other site 869309004835 phosphorylation site [posttranslational modification] 869309004837 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 869309004838 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 869309004839 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 869309004840 active site 869309004841 DNA polymerase IV; Validated; Region: PRK02406 869309004842 DNA binding site [nucleotide binding] 869309004843 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 869309004844 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 869309004845 Transposase; Region: DEDD_Tnp_IS110; pfam01548 869309004846 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 869309004847 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 869309004849 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 869309004850 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309004851 Walker A/P-loop; other site 869309004852 ATP binding site [chemical binding]; other site 869309004853 Q-loop/lid; other site 869309004854 ABC transporter signature motif; other site 869309004855 Walker B; other site 869309004856 D-loop; other site 869309004857 H-loop/switch region; other site 869309004858 threonine dehydratase; Validated; Region: PRK08639 869309004859 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 869309004860 tetramer interface [polypeptide binding]; other site 869309004861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869309004862 catalytic residue [active] 869309004863 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 869309004864 ketol-acid reductoisomerase; Provisional; Region: PRK05479 869309004865 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 869309004866 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 869309004867 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 869309004868 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 869309004869 putative valine binding site [chemical binding]; other site 869309004870 dimer interface [polypeptide binding]; other site 869309004871 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 869309004872 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 869309004873 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 869309004874 PYR/PP interface [polypeptide binding]; other site 869309004875 dimer interface [polypeptide binding]; other site 869309004876 TPP binding site [chemical binding]; other site 869309004877 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 869309004878 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 869309004879 TPP-binding site [chemical binding]; other site 869309004880 dimer interface [polypeptide binding]; other site 869309004881 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 869309004882 DAK2 domain; Region: Dak2; pfam02734 869309004883 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 869309004884 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 869309004886 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 869309004887 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 869309004888 G1 box; other site 869309004889 putative GEF interaction site [polypeptide binding]; other site 869309004890 GTP/Mg2+ binding site [chemical binding]; other site 869309004891 Switch I region; other site 869309004892 G2 box; other site 869309004893 G3 box; other site 869309004894 Switch II region; other site 869309004895 G4 box; other site 869309004896 G5 box; other site 869309004897 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 869309004898 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 869309004899 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 869309004900 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 869309004901 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 869309004902 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 869309004903 GatB domain; Region: GatB_Yqey; pfam02637 869309004904 elongation factor P; Validated; Region: PRK00529 869309004905 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 869309004906 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 869309004907 RNA binding site [nucleotide binding]; other site 869309004908 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 869309004909 RNA binding site [nucleotide binding]; other site 869309004910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 869309004911 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 869309004912 putative RNA binding site [nucleotide binding]; other site 869309004913 CAAX protease self-immunity; Region: Abi; pfam02517 869309004914 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 869309004915 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 869309004916 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 869309004917 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 869309004918 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 869309004919 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 869309004920 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 869309004921 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 869309004922 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 869309004923 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 869309004924 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 869309004925 carboxyltransferase (CT) interaction site; other site 869309004926 biotinylation site [posttranslational modification]; other site 869309004927 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 869309004928 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 869309004929 dimer interface [polypeptide binding]; other site 869309004930 active site 869309004931 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 869309004932 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 869309004933 NAD(P) binding site [chemical binding]; other site 869309004934 homotetramer interface [polypeptide binding]; other site 869309004935 homodimer interface [polypeptide binding]; other site 869309004936 active site 869309004937 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 869309004938 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 869309004939 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 869309004940 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 869309004941 FMN binding site [chemical binding]; other site 869309004942 substrate binding site [chemical binding]; other site 869309004943 putative catalytic residue [active] 869309004944 acyl carrier protein; Provisional; Region: acpP; PRK00982 869309004945 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 869309004946 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 869309004947 dimer interface [polypeptide binding]; other site 869309004948 active site 869309004949 CoA binding pocket [chemical binding]; other site 869309004950 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 869309004951 MarR family; Region: MarR_2; pfam12802 869309004952 enoyl-CoA hydratase; Provisional; Region: PRK07260 869309004953 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 869309004954 substrate binding site [chemical binding]; other site 869309004955 oxyanion hole (OAH) forming residues; other site 869309004956 trimer interface [polypeptide binding]; other site 869309004957 aspartate kinase; Reviewed; Region: PRK09034 869309004958 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 869309004959 putative catalytic residues [active] 869309004960 putative nucleotide binding site [chemical binding]; other site 869309004961 putative aspartate binding site [chemical binding]; other site 869309004962 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 869309004963 allosteric regulatory residue; other site 869309004964 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 869309004965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 869309004966 seryl-tRNA synthetase; Provisional; Region: PRK05431 869309004967 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 869309004968 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 869309004969 dimer interface [polypeptide binding]; other site 869309004970 active site 869309004971 motif 1; other site 869309004972 motif 2; other site 869309004973 motif 3; other site 869309004974 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 869309004975 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 869309004976 gating phenylalanine in ion channel; other site 869309004977 Uncharacterized conserved protein [Function unknown]; Region: COG2128 869309004978 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 869309004979 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 869309004980 amino acid carrier protein; Region: agcS; TIGR00835 869309004981 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 869309004982 MutS domain III; Region: MutS_III; pfam05192 869309004983 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 869309004984 Walker A/P-loop; other site 869309004985 ATP binding site [chemical binding]; other site 869309004986 Q-loop/lid; other site 869309004987 ABC transporter signature motif; other site 869309004988 Walker B; other site 869309004989 D-loop; other site 869309004990 H-loop/switch region; other site 869309004991 Smr domain; Region: Smr; pfam01713 869309004992 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 869309004993 Colicin V production protein; Region: Colicin_V; pfam02674 869309004994 ribonuclease HIII; Provisional; Region: PRK00996 869309004995 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 869309004996 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 869309004997 RNA/DNA hybrid binding site [nucleotide binding]; other site 869309004998 active site 869309004999 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 869309005000 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 869309005001 Catalytic site [active] 869309005002 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 869309005003 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 869309005004 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 869309005005 DNA binding site [nucleotide binding] 869309005006 AAA domain; Region: AAA_30; pfam13604 869309005007 Family description; Region: UvrD_C_2; pfam13538 869309005008 trigger factor; Provisional; Region: tig; PRK01490 869309005009 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 869309005010 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 869309005011 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 869309005012 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 869309005013 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 869309005014 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 869309005015 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 869309005016 active site 869309005017 phosphorylation site [posttranslational modification] 869309005018 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869309005019 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869309005020 active site 869309005021 P-loop; other site 869309005022 phosphorylation site [posttranslational modification] 869309005023 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 869309005024 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 869309005025 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 869309005026 active site 869309005027 P-loop; other site 869309005028 phosphorylation site [posttranslational modification] 869309005029 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 869309005030 active site 869309005031 P-loop; other site 869309005032 phosphorylation site [posttranslational modification] 869309005035 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 869309005037 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 869309005038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309005039 active site 869309005040 phosphorylation site [posttranslational modification] 869309005041 intermolecular recognition site; other site 869309005042 dimerization interface [polypeptide binding]; other site 869309005043 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 869309005044 DNA binding residues [nucleotide binding] 869309005045 dimerization interface [polypeptide binding]; other site 869309005046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869309005047 Histidine kinase; Region: HisKA_3; pfam07730 869309005048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869309005049 ATP binding site [chemical binding]; other site 869309005050 Mg2+ binding site [ion binding]; other site 869309005051 G-X-G motif; other site 869309005052 Predicted membrane protein [Function unknown]; Region: COG4758 869309005053 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 869309005054 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 869309005055 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 869309005056 homotetramer interface [polypeptide binding]; other site 869309005057 FMN binding site [chemical binding]; other site 869309005058 homodimer contacts [polypeptide binding]; other site 869309005059 putative active site [active] 869309005060 putative substrate binding site [chemical binding]; other site 869309005061 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 869309005062 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869309005063 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 869309005064 diphosphomevalonate decarboxylase; Region: PLN02407 869309005065 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 869309005066 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 869309005067 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 869309005069 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 869309005070 active site 869309005071 zinc binding site [ion binding]; other site 869309005072 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 869309005073 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 869309005074 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 869309005075 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869309005076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309005077 active site 869309005078 phosphorylation site [posttranslational modification] 869309005079 intermolecular recognition site; other site 869309005080 dimerization interface [polypeptide binding]; other site 869309005081 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869309005082 DNA binding site [nucleotide binding] 869309005083 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869309005084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309005085 active site 869309005086 phosphorylation site [posttranslational modification] 869309005087 intermolecular recognition site; other site 869309005088 dimerization interface [polypeptide binding]; other site 869309005089 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869309005090 DNA binding site [nucleotide binding] 869309005091 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 869309005092 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 869309005093 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 869309005094 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 869309005095 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 869309005096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 869309005097 cell division protein GpsB; Provisional; Region: PRK14127 869309005098 DivIVA domain; Region: DivI1A_domain; TIGR03544 869309005099 hypothetical protein; Provisional; Region: PRK13660 869309005100 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 869309005101 Transglycosylase; Region: Transgly; pfam00912 869309005102 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 869309005103 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 869309005104 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869309005105 Alpha amylase catalytic domain family; Region: AmyAc_family; cd00551 869309005106 active site 869309005107 catalytic site [active] 869309005108 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 869309005109 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 869309005110 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 869309005111 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 869309005112 active site 869309005113 substrate binding site [chemical binding]; other site 869309005114 metal binding site [ion binding]; metal-binding site 869309005115 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 869309005116 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 869309005117 active site 869309005118 tetramer interface; other site 869309005119 Hyaluronan synthases catalyze polymerization of hyaluronan; Region: GT2_HAS; cd06434 869309005120 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 869309005121 DXD motif; other site 869309005122 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 869309005123 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 869309005124 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 869309005125 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 869309005126 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869309005127 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 869309005128 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 869309005129 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 869309005133 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 869309005134 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 869309005135 Ca binding site [ion binding]; other site 869309005136 active site 869309005137 catalytic site [active] 869309005138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 869309005139 hypothetical protein; Provisional; Region: PRK13663 869309005140 LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854 869309005143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309005144 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869309005145 Walker A motif; other site 869309005146 ATP binding site [chemical binding]; other site 869309005147 Walker B motif; other site 869309005148 arginine finger; other site 869309005149 UvrB/uvrC motif; Region: UVR; pfam02151 869309005150 MoxR-like ATPases [General function prediction only]; Region: COG0714 869309005151 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309005152 Walker A motif; other site 869309005153 ATP binding site [chemical binding]; other site 869309005154 Walker B motif; other site 869309005155 arginine finger; other site 869309005156 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869309005157 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309005158 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869309005159 Walker A motif; other site 869309005160 ATP binding site [chemical binding]; other site 869309005161 Walker B motif; other site 869309005162 arginine finger; other site 869309005163 UvrB/uvrC motif; Region: UVR; pfam02151 869309005164 MoxR-like ATPases [General function prediction only]; Region: COG0714 869309005165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309005166 Walker A motif; other site 869309005167 ATP binding site [chemical binding]; other site 869309005168 Walker B motif; other site 869309005169 arginine finger; other site 869309005170 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 869309005171 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 869309005172 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 869309005173 Mg++ binding site [ion binding]; other site 869309005174 putative catalytic motif [active] 869309005175 putative substrate binding site [chemical binding]; other site 869309005176 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 869309005177 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 869309005178 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 869309005179 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 869309005180 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 869309005181 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 869309005182 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 869309005183 MraW methylase family; Region: Methyltransf_5; pfam01795 869309005184 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309005185 non-specific DNA binding site [nucleotide binding]; other site 869309005186 salt bridge; other site 869309005187 sequence-specific DNA binding site [nucleotide binding]; other site 869309005188 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 869309005189 Transcriptional regulators [Transcription]; Region: PurR; COG1609 869309005190 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 869309005191 DNA binding site [nucleotide binding] 869309005192 domain linker motif; other site 869309005193 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 869309005194 putative dimerization interface [polypeptide binding]; other site 869309005195 putative ligand binding site [chemical binding]; other site 869309005196 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 869309005197 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 869309005198 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869309005199 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 869309005200 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869309005201 active site 869309005202 phosphorylation site [posttranslational modification] 869309005203 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 869309005204 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869309005205 active pocket/dimerization site; other site 869309005206 active site 869309005207 phosphorylation site [posttranslational modification] 869309005208 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 869309005209 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 869309005210 NADP binding site [chemical binding]; other site 869309005211 homodimer interface [polypeptide binding]; other site 869309005212 active site 869309005213 hypothetical protein; Provisional; Region: PRK09273 869309005214 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 869309005215 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 869309005216 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 869309005217 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 869309005218 substrate binding site [chemical binding]; other site 869309005219 ATP binding site [chemical binding]; other site 869309005220 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 869309005221 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 869309005222 active site 869309005223 intersubunit interface [polypeptide binding]; other site 869309005224 catalytic residue [active] 869309005225 Transposase IS200 like; Region: Y1_Tnp; pfam01797 869309005226 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 869309005227 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 869309005228 substrate binding site [chemical binding]; other site 869309005229 catalytic residues [active] 869309005230 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 869309005231 catalytic residues [active] 869309005232 dimer interface [polypeptide binding]; other site 869309005233 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 869309005234 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 869309005235 putative active site [active] 869309005236 putative catalytic site [active] 869309005238 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 869309005239 HTH domain; Region: HTH_11; pfam08279 869309005240 Mga helix-turn-helix domain; Region: Mga; pfam05043 869309005241 PRD domain; Region: PRD; pfam00874 869309005242 PRD domain; Region: PRD; pfam00874 869309005243 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 869309005244 active site 869309005245 P-loop; other site 869309005246 phosphorylation site [posttranslational modification] 869309005247 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 869309005248 active site 869309005249 phosphorylation site [posttranslational modification] 869309005250 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 869309005251 active site 869309005252 P-loop; other site 869309005253 phosphorylation site [posttranslational modification] 869309005254 Uncharacterized conserved protein [Function unknown]; Region: COG4095 869309005255 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 869309005256 beta-galactosidase; Region: BGL; TIGR03356 869309005257 Uncharacterized conserved protein [Function unknown]; Region: COG1359 869309005259 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 869309005260 putative catalytic site [active] 869309005261 putative metal binding site [ion binding]; other site 869309005262 putative phosphate binding site [ion binding]; other site 869309005263 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 869309005264 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869309005265 argininosuccinate lyase; Region: PLN02646 869309005266 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 869309005267 active site 869309005268 metal binding site [ion binding]; metal-binding site 869309005269 putative replication initiation protein; Region: PHA00330 869309005270 Helix-turn-helix domain; Region: HTH_17; pfam12728 869309005272 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 869309005273 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 869309005274 23S rRNA interface [nucleotide binding]; other site 869309005275 L3 interface [polypeptide binding]; other site 869309005276 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 869309005277 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 869309005278 homooctamer interface [polypeptide binding]; other site 869309005279 active site 869309005280 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 869309005281 catalytic center binding site [active] 869309005282 ATP binding site [chemical binding]; other site 869309005283 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 869309005284 homodecamer interface [polypeptide binding]; other site 869309005285 GTP cyclohydrolase I; Provisional; Region: PLN03044 869309005286 active site 869309005287 putative catalytic site residues [active] 869309005288 zinc binding site [ion binding]; other site 869309005289 GTP-CH-I/GFRP interaction surface; other site 869309005290 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 869309005291 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 869309005292 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869309005293 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 869309005294 dihydropteroate synthase; Region: DHPS; TIGR01496 869309005295 substrate binding pocket [chemical binding]; other site 869309005296 dimer interface [polypeptide binding]; other site 869309005297 inhibitor binding site; inhibition site 869309005298 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 869309005299 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 869309005300 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 869309005301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309005302 active site 869309005303 motif I; other site 869309005304 motif II; other site 869309005305 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 869309005306 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 869309005307 NAD binding site [chemical binding]; other site 869309005308 substrate binding site [chemical binding]; other site 869309005309 catalytic Zn binding site [ion binding]; other site 869309005310 tetramer interface [polypeptide binding]; other site 869309005311 structural Zn binding site [ion binding]; other site 869309005312 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 869309005313 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869309005314 active pocket/dimerization site; other site 869309005315 active site 869309005316 phosphorylation site [posttranslational modification] 869309005317 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869309005318 active site 869309005319 phosphorylation site [posttranslational modification] 869309005320 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 869309005321 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869309005322 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 869309005323 trimer interface [polypeptide binding]; other site 869309005324 active site 869309005325 G bulge; other site 869309005326 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 869309005327 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869309005328 RNA binding surface [nucleotide binding]; other site 869309005329 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 869309005330 active site 869309005331 uracil binding [chemical binding]; other site 869309005333 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 869309005334 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 869309005335 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 869309005336 DNA polymerase III PolC; Validated; Region: polC; PRK00448 869309005337 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 869309005338 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 869309005339 generic binding surface II; other site 869309005340 generic binding surface I; other site 869309005341 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 869309005342 active site 869309005343 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 869309005344 active site 869309005345 catalytic site [active] 869309005346 substrate binding site [chemical binding]; other site 869309005347 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 869309005348 putative PHP Thumb interface [polypeptide binding]; other site 869309005349 active site 869309005350 elongation factor G; Reviewed; Region: PRK00007 869309005351 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 869309005352 G1 box; other site 869309005353 putative GEF interaction site [polypeptide binding]; other site 869309005354 GTP/Mg2+ binding site [chemical binding]; other site 869309005355 Switch I region; other site 869309005356 G2 box; other site 869309005357 G3 box; other site 869309005358 Switch II region; other site 869309005359 G4 box; other site 869309005360 G5 box; other site 869309005361 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 869309005362 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 869309005363 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 869309005364 30S ribosomal protein S7; Validated; Region: PRK05302 869309005365 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 869309005366 S17 interaction site [polypeptide binding]; other site 869309005367 S8 interaction site; other site 869309005368 16S rRNA interaction site [nucleotide binding]; other site 869309005369 streptomycin interaction site [chemical binding]; other site 869309005370 23S rRNA interaction site [nucleotide binding]; other site 869309005371 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 869309005372 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869309005373 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 869309005374 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 869309005375 carbohydrate binding site [chemical binding]; other site 869309005376 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 869309005377 carbohydrate binding site [chemical binding]; other site 869309005378 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 869309005379 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 869309005380 Ca binding site [ion binding]; other site 869309005381 active site 869309005382 catalytic site [active] 869309005383 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 869309005384 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 869309005385 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 869309005386 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 869309005387 glutaminase active site [active] 869309005388 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 869309005389 dimer interface [polypeptide binding]; other site 869309005390 active site 869309005391 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 869309005392 dimer interface [polypeptide binding]; other site 869309005393 active site 869309005394 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 869309005395 beta-galactosidase; Region: BGL; TIGR03356 869309005396 prolyl-tRNA synthetase; Provisional; Region: PRK09194 869309005397 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 869309005398 dimer interface [polypeptide binding]; other site 869309005399 motif 1; other site 869309005400 active site 869309005401 motif 2; other site 869309005402 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 869309005403 putative deacylase active site [active] 869309005404 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 869309005405 active site 869309005406 motif 3; other site 869309005407 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 869309005408 anticodon binding site; other site 869309005409 RIP metalloprotease RseP; Region: TIGR00054 869309005410 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 869309005411 active site 869309005412 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 869309005413 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 869309005414 putative substrate binding region [chemical binding]; other site 869309005415 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 869309005416 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 869309005417 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 869309005418 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 869309005419 catalytic residue [active] 869309005420 putative FPP diphosphate binding site; other site 869309005421 putative FPP binding hydrophobic cleft; other site 869309005422 dimer interface [polypeptide binding]; other site 869309005423 putative IPP diphosphate binding site; other site 869309005424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 869309005425 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 869309005426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309005427 Walker A motif; other site 869309005428 ATP binding site [chemical binding]; other site 869309005429 Walker B motif; other site 869309005430 arginine finger; other site 869309005431 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 869309005433 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 869309005434 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 869309005435 HIGH motif; other site 869309005436 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 869309005437 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869309005438 active site 869309005439 KMSKS motif; other site 869309005440 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 869309005441 tRNA binding surface [nucleotide binding]; other site 869309005442 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 869309005443 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 869309005444 dimer interface [polypeptide binding]; other site 869309005445 active site 869309005446 metal binding site [ion binding]; metal-binding site 869309005447 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 869309005448 active site 869309005449 intersubunit interactions; other site 869309005450 catalytic residue [active] 869309005451 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 869309005452 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 869309005453 dimer interface [polypeptide binding]; other site 869309005454 active site 869309005455 glycine loop; other site 869309005456 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 869309005457 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 869309005458 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 869309005459 active site 869309005460 P-loop; other site 869309005461 phosphorylation site [posttranslational modification] 869309005462 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 869309005463 active site 869309005464 methionine cluster; other site 869309005465 phosphorylation site [posttranslational modification] 869309005466 metal binding site [ion binding]; metal-binding site 869309005467 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 869309005468 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 869309005469 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869309005470 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869309005471 DNA-binding site [nucleotide binding]; DNA binding site 869309005472 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869309005473 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 869309005474 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 869309005475 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869309005476 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 869309005477 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 869309005478 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 869309005479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309005480 Walker A/P-loop; other site 869309005481 ATP binding site [chemical binding]; other site 869309005482 Q-loop/lid; other site 869309005483 ABC transporter signature motif; other site 869309005484 Walker B; other site 869309005485 D-loop; other site 869309005486 H-loop/switch region; other site 869309005487 TOBE domain; Region: TOBE_2; pfam08402 869309005490 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869309005491 catalytic core [active] 869309005492 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 869309005493 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 869309005494 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 869309005495 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 869309005496 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 869309005497 alphaNTD homodimer interface [polypeptide binding]; other site 869309005498 alphaNTD - beta interaction site [polypeptide binding]; other site 869309005499 alphaNTD - beta' interaction site [polypeptide binding]; other site 869309005500 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 869309005501 30S ribosomal protein S11; Validated; Region: PRK05309 869309005502 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 869309005503 30S ribosomal protein S13; Region: bact_S13; TIGR03631 869309005504 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 869309005505 rRNA binding site [nucleotide binding]; other site 869309005506 predicted 30S ribosome binding site; other site 869309005507 adenylate kinase; Reviewed; Region: adk; PRK00279 869309005508 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 869309005509 AMP-binding site [chemical binding]; other site 869309005510 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 869309005511 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 869309005512 SecY translocase; Region: SecY; pfam00344 869309005513 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 869309005514 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 869309005515 23S rRNA binding site [nucleotide binding]; other site 869309005516 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 869309005517 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 869309005518 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 869309005519 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 869309005520 5S rRNA interface [nucleotide binding]; other site 869309005521 L27 interface [polypeptide binding]; other site 869309005522 23S rRNA interface [nucleotide binding]; other site 869309005523 L5 interface [polypeptide binding]; other site 869309005524 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 869309005525 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869309005526 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 869309005527 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 869309005528 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 869309005529 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 869309005530 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 869309005531 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 869309005532 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 869309005533 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 869309005534 RNA binding site [nucleotide binding]; other site 869309005535 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 869309005536 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 869309005537 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 869309005538 23S rRNA interface [nucleotide binding]; other site 869309005539 putative translocon interaction site; other site 869309005540 signal recognition particle (SRP54) interaction site; other site 869309005541 L23 interface [polypeptide binding]; other site 869309005542 trigger factor interaction site; other site 869309005543 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 869309005544 23S rRNA interface [nucleotide binding]; other site 869309005545 5S rRNA interface [nucleotide binding]; other site 869309005546 putative antibiotic binding site [chemical binding]; other site 869309005547 L25 interface [polypeptide binding]; other site 869309005548 L27 interface [polypeptide binding]; other site 869309005549 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 869309005550 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 869309005551 G-X-X-G motif; other site 869309005552 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 869309005553 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 869309005554 putative translocon binding site; other site 869309005555 protein-rRNA interface [nucleotide binding]; other site 869309005556 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 869309005557 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 869309005558 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 869309005559 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 869309005560 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 869309005561 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 869309005562 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 869309005563 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 869309005564 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 869309005565 active site 869309005566 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 869309005567 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 869309005568 FeS/SAM binding site; other site 869309005569 Predicted acetyltransferase [General function prediction only]; Region: COG3981 869309005570 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 869309005571 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 869309005572 ATP cone domain; Region: ATP-cone; pfam03477 869309005573 Class III ribonucleotide reductase; Region: RNR_III; cd01675 869309005574 effector binding site; other site 869309005575 active site 869309005576 Zn binding site [ion binding]; other site 869309005577 glycine loop; other site 869309005578 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 869309005579 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 869309005580 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 869309005581 putative active site [active] 869309005582 catalytic site [active] 869309005583 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 869309005584 putative active site [active] 869309005585 catalytic site [active] 869309005586 Bacterial lipoprotein; Region: DUF3642; pfam12182 869309005587 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 869309005588 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 869309005589 hypothetical protein; Provisional; Region: PRK13678 869309005590 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4472 869309005591 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 869309005592 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 869309005593 hypothetical protein; Provisional; Region: PRK05473 869309005594 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 869309005595 ArsC family; Region: ArsC; pfam03960 869309005596 putative catalytic residues [active] 869309005597 thiol/disulfide switch; other site 869309005598 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 869309005599 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 869309005600 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 869309005601 active site 869309005602 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 869309005603 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869309005604 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 869309005605 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 869309005606 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 869309005607 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 869309005608 Cl binding site [ion binding]; other site 869309005609 oligomer interface [polypeptide binding]; other site 869309005610 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 869309005611 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 869309005612 putative dimer interface [polypeptide binding]; other site 869309005613 catalytic triad [active] 869309005614 CAAX protease self-immunity; Region: Abi; pfam02517 869309005615 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 869309005616 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 869309005617 RuvA N terminal domain; Region: RuvA_N; pfam01330 869309005618 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 869309005619 catalytic motif [active] 869309005620 Zn binding site [ion binding]; other site 869309005621 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 869309005622 RibD C-terminal domain; Region: RibD_C; cl17279 869309005623 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 869309005624 Lumazine binding domain; Region: Lum_binding; pfam00677 869309005625 Lumazine binding domain; Region: Lum_binding; pfam00677 869309005626 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 869309005627 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 869309005628 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 869309005629 dimerization interface [polypeptide binding]; other site 869309005630 active site 869309005631 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 869309005632 homopentamer interface [polypeptide binding]; other site 869309005633 active site 869309005634 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 869309005635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869309005636 ATP binding site [chemical binding]; other site 869309005637 Mg2+ binding site [ion binding]; other site 869309005638 G-X-G motif; other site 869309005639 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 869309005640 ATP binding site [chemical binding]; other site 869309005641 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 869309005642 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869309005643 LytTr DNA-binding domain; Region: LytTR; smart00850 869309005644 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 869309005645 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 869309005646 flavoprotein NrdI; Provisional; Region: PRK02551 869309005647 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 869309005648 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 869309005649 Int/Topo IB signature motif; other site 869309005650 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 869309005651 BRO family, N-terminal domain; Region: Bro-N; pfam02498 869309005652 Protein of unknown function (DUF3102); Region: DUF3102; pfam11300 869309005653 Fic family protein [Function unknown]; Region: COG3177 869309005654 Fic/DOC family; Region: Fic; pfam02661 869309005655 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 869309005656 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 869309005657 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309005658 non-specific DNA binding site [nucleotide binding]; other site 869309005659 salt bridge; other site 869309005660 sequence-specific DNA binding site [nucleotide binding]; other site 869309005661 Predicted transcriptional regulator [Transcription]; Region: COG2932 869309005662 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 869309005663 Catalytic site [active] 869309005664 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646 869309005665 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 869309005666 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 869309005667 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 869309005668 D5 N terminal like; Region: D5_N; smart00885 869309005669 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 869309005670 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 869309005671 AntA/AntB antirepressor; Region: AntA; cl01430 869309005672 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 869309005673 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 869309005674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309005675 active site 869309005676 phosphorylation site [posttranslational modification] 869309005677 intermolecular recognition site; other site 869309005678 dimerization interface [polypeptide binding]; other site 869309005679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 869309005680 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 869309005681 HAMP domain; Region: HAMP; pfam00672 869309005682 Histidine kinase; Region: His_kinase; pfam06580 869309005683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869309005684 ATP binding site [chemical binding]; other site 869309005685 Mg2+ binding site [ion binding]; other site 869309005686 G-X-G motif; other site 869309005687 Predicted integral membrane protein [Function unknown]; Region: COG5578 869309005688 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 869309005689 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 869309005690 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 869309005691 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 869309005692 Walker A/P-loop; other site 869309005693 ATP binding site [chemical binding]; other site 869309005694 Q-loop/lid; other site 869309005695 ABC transporter signature motif; other site 869309005696 Walker B; other site 869309005697 D-loop; other site 869309005698 H-loop/switch region; other site 869309005699 NIL domain; Region: NIL; pfam09383 869309005700 hypothetical protein; Provisional; Region: PRK06446 869309005701 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 869309005702 metal binding site [ion binding]; metal-binding site 869309005703 dimer interface [polypeptide binding]; other site 869309005705 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869309005706 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869309005707 substrate binding pocket [chemical binding]; other site 869309005708 membrane-bound complex binding site; other site 869309005709 hinge residues; other site 869309005713 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 869309005714 non-specific DNA binding site [nucleotide binding]; other site 869309005715 salt bridge; other site 869309005716 sequence-specific DNA binding site [nucleotide binding]; other site 869309005717 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 869309005718 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 869309005719 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 869309005720 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 869309005721 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 869309005722 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 869309005723 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869309005724 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 869309005725 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869309005726 Walker A/P-loop; other site 869309005727 ATP binding site [chemical binding]; other site 869309005728 Q-loop/lid; other site 869309005729 ABC transporter signature motif; other site 869309005730 Walker B; other site 869309005731 D-loop; other site 869309005732 H-loop/switch region; other site 869309005733 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 869309005734 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 869309005735 active site 869309005739 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869309005740 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869309005741 UGMP family protein; Validated; Region: PRK09604 869309005742 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 869309005743 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 869309005744 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 869309005745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 869309005746 Coenzyme A binding pocket [chemical binding]; other site 869309005747 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 869309005748 Glycoprotease family; Region: Peptidase_M22; pfam00814 869309005749 class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949 869309005750 hypothetical protein; Provisional; Region: PRK13667 869309005751 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 869309005752 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 869309005753 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 869309005755 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 869309005756 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 869309005757 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 869309005758 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 869309005759 nudix motif; other site 869309005760 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 869309005761 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 869309005762 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 869309005763 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309005764 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 869309005765 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309005766 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309005767 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309005768 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 869309005769 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309005770 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309005771 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309005772 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 869309005773 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309005774 missing C-terminus 869309005775 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 869309005777 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 869309005778 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 869309005779 substrate binding pocket [chemical binding]; other site 869309005780 membrane-bound complex binding site; other site 869309005781 hinge residues; other site 869309005782 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 869309005783 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 869309005784 Walker A/P-loop; other site 869309005785 ATP binding site [chemical binding]; other site 869309005786 Q-loop/lid; other site 869309005787 ABC transporter signature motif; other site 869309005788 Walker B; other site 869309005789 D-loop; other site 869309005790 H-loop/switch region; other site 869309005792 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683 869309005793 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 869309005794 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 869309005795 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 869309005796 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 869309005797 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 869309005798 putative L-serine binding site [chemical binding]; other site 869309005799 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 869309005800 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 869309005801 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 869309005802 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 869309005803 active site 869309005804 motif I; other site 869309005805 motif II; other site 869309005806 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 869309005807 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 869309005808 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 869309005809 NAD(P) binding site [chemical binding]; other site 869309005810 homodimer interface [polypeptide binding]; other site 869309005811 substrate binding site [chemical binding]; other site 869309005812 active site 869309005813 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 869309005814 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 869309005815 Ligand binding site; other site 869309005816 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 869309005817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 869309005818 putative substrate translocation pore; other site 869309005819 Predicted transcriptional regulators [Transcription]; Region: COG1695 869309005820 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 869309005821 Predicted membrane protein [Function unknown]; Region: COG4709 869309005822 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 869309005823 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 869309005824 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 869309005825 active site residue [active] 869309005826 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 869309005827 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 869309005828 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 869309005829 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 869309005830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309005831 dimer interface [polypeptide binding]; other site 869309005832 conserved gate region; other site 869309005833 putative PBP binding loops; other site 869309005834 ABC-ATPase subunit interface; other site 869309005835 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 869309005836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 869309005837 dimer interface [polypeptide binding]; other site 869309005838 conserved gate region; other site 869309005839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 869309005840 ABC-ATPase subunit interface; other site 869309005842 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 869309005843 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 869309005844 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 869309005845 RNA binding surface [nucleotide binding]; other site 869309005846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869309005847 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869309005848 dimerization interface [polypeptide binding]; other site 869309005849 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869309005850 dimer interface [polypeptide binding]; other site 869309005851 phosphorylation site [posttranslational modification] 869309005852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869309005853 ATP binding site [chemical binding]; other site 869309005854 Mg2+ binding site [ion binding]; other site 869309005855 G-X-G motif; other site 869309005856 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869309005857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309005858 active site 869309005859 phosphorylation site [posttranslational modification] 869309005860 intermolecular recognition site; other site 869309005861 dimerization interface [polypeptide binding]; other site 869309005862 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869309005863 DNA binding site [nucleotide binding] 869309005864 Fibronectin-binding repeat; Region: SSURE; pfam11966 869309005865 Fibronectin-binding repeat; Region: SSURE; pfam11966 869309005866 Fibronectin-binding repeat; Region: SSURE; pfam11966 869309005867 Fibronectin-binding repeat; Region: SSURE; pfam11966 869309005869 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 869309005870 TrkA-N domain; Region: TrkA_N; pfam02254 869309005871 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 869309005872 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 869309005873 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 869309005874 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 869309005875 active site residue [active] 869309005876 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 869309005877 active site residue [active] 869309005878 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 869309005879 putative homodimer-homodimer interface [polypeptide binding]; other site 869309005880 putative allosteric switch controlling residues; other site 869309005881 putative metal binding site [ion binding]; other site 869309005882 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 869309005883 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 869309005884 putative metal binding site [ion binding]; other site 869309005885 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 869309005886 active site 869309005887 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 869309005888 active site 869309005889 catalytic residues [active] 869309005890 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 869309005891 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 869309005892 dimer interface [polypeptide binding]; other site 869309005893 active site 869309005894 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 869309005895 putative active site [active] 869309005896 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869309005897 active pocket/dimerization site; other site 869309005898 active site 869309005899 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869309005900 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 869309005901 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869309005902 active site 869309005903 phosphorylation site [posttranslational modification] 869309005904 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 869309005905 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 869309005906 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 869309005907 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 869309005908 DNA-binding site [nucleotide binding]; DNA binding site 869309005909 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 869309005910 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869309005911 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 869309005912 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 869309005913 active site 869309005914 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 869309005915 active site 869309005916 G5 domain; Region: G5; pfam07501 869309005917 G5 domain; Region: G5; pfam07501 869309005918 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 869309005919 adenylosuccinate lyase; Provisional; Region: PRK07492 869309005920 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 869309005921 tetramer interface [polypeptide binding]; other site 869309005922 active site 869309005923 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 869309005924 ATP-grasp domain; Region: ATP-grasp; pfam02222 869309005925 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 869309005926 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 869309005927 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 869309005928 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 869309005929 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 869309005930 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 869309005931 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 869309005932 purine monophosphate binding site [chemical binding]; other site 869309005933 dimer interface [polypeptide binding]; other site 869309005934 putative catalytic residues [active] 869309005935 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 869309005936 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 869309005937 VanZ like family; Region: VanZ; pfam04892 869309005938 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 869309005939 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 869309005940 active site 869309005941 substrate binding site [chemical binding]; other site 869309005942 cosubstrate binding site; other site 869309005943 catalytic site [active] 869309005944 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 869309005945 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 869309005946 dimerization interface [polypeptide binding]; other site 869309005947 putative ATP binding site [chemical binding]; other site 869309005948 amidophosphoribosyltransferase; Provisional; Region: PRK07272 869309005949 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 869309005950 active site 869309005951 tetramer interface [polypeptide binding]; other site 869309005952 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869309005953 active site 869309005954 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 869309005955 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 869309005956 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 869309005957 dimerization interface [polypeptide binding]; other site 869309005958 ATP binding site [chemical binding]; other site 869309005959 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 869309005960 dimerization interface [polypeptide binding]; other site 869309005961 ATP binding site [chemical binding]; other site 869309005962 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 869309005963 putative active site [active] 869309005964 catalytic triad [active] 869309005965 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 869309005966 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 869309005967 ATP binding site [chemical binding]; other site 869309005968 active site 869309005969 substrate binding site [chemical binding]; other site 869309005970 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 869309005971 HlyD family secretion protein; Region: HlyD_3; pfam13437 869309005972 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 869309005973 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 869309005974 putative active site [active] 869309005975 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 869309005976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309005977 Walker A/P-loop; other site 869309005978 ATP binding site [chemical binding]; other site 869309005979 Q-loop/lid; other site 869309005980 ABC transporter signature motif; other site 869309005981 Walker B; other site 869309005982 D-loop; other site 869309005983 H-loop/switch region; other site 869309005984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 869309005985 putative phosphate acyltransferase; Provisional; Region: PRK05331 869309005986 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 869309005987 Recombination protein O N terminal; Region: RecO_N; pfam11967 869309005988 Recombination protein O C terminal; Region: RecO_C; pfam02565 869309005989 aromatic amino acid aminotransferase; Validated; Region: PRK07309 869309005990 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 869309005991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869309005992 homodimer interface [polypeptide binding]; other site 869309005993 catalytic residue [active] 869309005994 Predicted membrane protein [Function unknown]; Region: COG2855 869309005995 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 869309005996 DNA polymerase I; Provisional; Region: PRK05755 869309005997 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 869309005998 active site 869309005999 metal binding site 1 [ion binding]; metal-binding site 869309006000 putative 5' ssDNA interaction site; other site 869309006001 metal binding site 3; metal-binding site 869309006002 metal binding site 2 [ion binding]; metal-binding site 869309006003 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 869309006004 putative DNA binding site [nucleotide binding]; other site 869309006005 putative metal binding site [ion binding]; other site 869309006006 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 869309006007 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 869309006008 active site 869309006009 DNA binding site [nucleotide binding] 869309006010 catalytic site [active] 869309006011 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 869309006012 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 869309006013 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 869309006014 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869309006015 active site 869309006016 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 869309006017 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 869309006018 active site clefts [active] 869309006019 zinc binding site [ion binding]; other site 869309006020 dimer interface [polypeptide binding]; other site 869309006021 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 869309006022 Walker A motif; other site 869309006023 ATP binding site [chemical binding]; other site 869309006024 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 869309006025 Walker B motif; other site 869309006026 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 869309006027 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 869309006028 catalytic core [active] 869309006029 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 869309006030 trimer interface [polypeptide binding]; other site 869309006031 active site 869309006032 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 869309006033 nucleoside/Zn binding site; other site 869309006034 dimer interface [polypeptide binding]; other site 869309006035 catalytic motif [active] 869309006036 Amidinotransferase; Region: Amidinotransf; cl12043 869309006037 ornithine carbamoyltransferase; Validated; Region: PRK02102 869309006038 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 869309006039 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 869309006040 carbamate kinase; Reviewed; Region: PRK12686 869309006041 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 869309006042 putative substrate binding site [chemical binding]; other site 869309006043 nucleotide binding site [chemical binding]; other site 869309006044 nucleotide binding site [chemical binding]; other site 869309006045 homodimer interface [polypeptide binding]; other site 869309006046 Predicted membrane protein [Function unknown]; Region: COG1288 869309006047 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 869309006048 hypothetical protein; Provisional; Region: PRK07205 869309006049 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 869309006050 active site 869309006051 metal binding site [ion binding]; metal-binding site 869309006052 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 869309006053 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 869309006054 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 869309006055 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 869309006056 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 869309006057 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 869309006058 dimer interface [polypeptide binding]; other site 869309006059 active site 869309006060 metal binding site [ion binding]; metal-binding site 869309006061 L-fucose isomerase; Provisional; Region: fucI; PRK10991 869309006062 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 869309006063 hexamer (dimer of trimers) interface [polypeptide binding]; other site 869309006064 trimer interface [polypeptide binding]; other site 869309006065 substrate binding site [chemical binding]; other site 869309006066 Mn binding site [ion binding]; other site 869309006067 Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306 869309006068 Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307 869309006069 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 869309006070 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 869309006071 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 869309006072 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 869309006073 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 869309006074 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 869309006075 active site 869309006076 phosphorylation site [posttranslational modification] 869309006077 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 869309006078 active pocket/dimerization site; other site 869309006079 active site 869309006080 phosphorylation site [posttranslational modification] 869309006081 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 869309006082 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 869309006083 intersubunit interface [polypeptide binding]; other site 869309006084 active site 869309006085 Zn2+ binding site [ion binding]; other site 869309006086 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 869309006087 N- and C-terminal domain interface [polypeptide binding]; other site 869309006088 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 869309006089 active site 869309006090 putative catalytic site [active] 869309006091 metal binding site [ion binding]; metal-binding site 869309006092 ATP binding site [chemical binding]; other site 869309006093 carbohydrate binding site [chemical binding]; other site 869309006094 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 869309006095 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 869309006096 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 869309006097 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 869309006098 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 869309006099 metal binding site [ion binding]; metal-binding site 869309006100 YodA lipocalin-like domain; Region: YodA; pfam09223 869309006101 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 869309006102 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 869309006103 ABC-ATPase subunit interface; other site 869309006104 dimer interface [polypeptide binding]; other site 869309006105 putative PBP binding regions; other site 869309006106 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 869309006107 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 869309006108 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 869309006109 putative DNA binding site [nucleotide binding]; other site 869309006110 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 869309006111 DltD N-terminal region; Region: DltD_N; pfam04915 869309006112 DltD central region; Region: DltD_M; pfam04918 869309006113 DltD C-terminal region; Region: DltD_C; pfam04914 869309006114 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 869309006115 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 869309006116 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 869309006117 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 869309006118 acyl-activating enzyme (AAE) consensus motif; other site 869309006119 AMP binding site [chemical binding]; other site 869309006120 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 869309006121 amphipathic channel; other site 869309006122 Asn-Pro-Ala signature motifs; other site 869309006123 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 869309006124 glycerol kinase; Provisional; Region: glpK; PRK00047 869309006125 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 869309006126 N- and C-terminal domain interface [polypeptide binding]; other site 869309006127 active site 869309006128 MgATP binding site [chemical binding]; other site 869309006129 catalytic site [active] 869309006130 metal binding site [ion binding]; metal-binding site 869309006131 glycerol binding site [chemical binding]; other site 869309006132 homotetramer interface [polypeptide binding]; other site 869309006133 homodimer interface [polypeptide binding]; other site 869309006134 FBP binding site [chemical binding]; other site 869309006135 protein IIAGlc interface [polypeptide binding]; other site 869309006136 Mga helix-turn-helix domain; Region: Mga; pfam05043 869309006137 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 869309006138 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 869309006139 dimerization interface [polypeptide binding]; other site 869309006140 domain crossover interface; other site 869309006141 redox-dependent activation switch; other site 869309006142 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 869309006143 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 869309006144 FMN binding site [chemical binding]; other site 869309006145 active site 869309006146 catalytic residues [active] 869309006147 substrate binding site [chemical binding]; other site 869309006148 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869309006149 RICH domain; Region: RICH; pfam05062 869309006150 RICH domain; Region: RICH; pfam05062 869309006151 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 869309006153 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 869309006154 nudix motif; other site 869309006156 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 869309006157 active site 869309006158 KMSKS motif; other site 869309006159 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 869309006160 AAA domain; Region: AAA_28; pfam13521 869309006161 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 869309006162 Transposase; Region: DDE_Tnp_ISL3; pfam01610 869309006163 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 869309006164 RICH domain; Region: RICH; pfam05062 869309006165 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309006166 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309006167 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309006168 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 869309006169 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309006170 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309006171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 869309006172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 869309006173 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 869309006174 dimerization interface [polypeptide binding]; other site 869309006175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 869309006176 dimer interface [polypeptide binding]; other site 869309006177 phosphorylation site [posttranslational modification] 869309006178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 869309006179 ATP binding site [chemical binding]; other site 869309006180 Mg2+ binding site [ion binding]; other site 869309006181 G-X-G motif; other site 869309006182 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 869309006183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309006184 active site 869309006185 phosphorylation site [posttranslational modification] 869309006186 intermolecular recognition site; other site 869309006187 dimerization interface [polypeptide binding]; other site 869309006188 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 869309006189 DNA binding site [nucleotide binding] 869309006190 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 869309006191 Clp amino terminal domain; Region: Clp_N; pfam02861 869309006192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309006193 Walker A motif; other site 869309006194 ATP binding site [chemical binding]; other site 869309006195 Walker B motif; other site 869309006196 arginine finger; other site 869309006197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 869309006198 Walker A motif; other site 869309006199 ATP binding site [chemical binding]; other site 869309006200 Walker B motif; other site 869309006201 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 869309006202 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 869309006203 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 869309006204 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 869309006205 Walker A/P-loop; other site 869309006206 ATP binding site [chemical binding]; other site 869309006207 Q-loop/lid; other site 869309006208 ABC transporter signature motif; other site 869309006209 Walker B; other site 869309006210 D-loop; other site 869309006211 H-loop/switch region; other site 869309006212 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 869309006213 NMT1/THI5 like; Region: NMT1; pfam09084 869309006214 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 869309006215 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 869309006216 Uncharacterized conserved protein [Function unknown]; Region: COG0011 869309006217 Surface antigen [General function prediction only]; Region: COG3942 869309006218 CHAP domain; Region: CHAP; pfam05257 869309006219 Bacterial SH3 domain; Region: SH3_5; pfam08460 869309006220 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 869309006221 Bacterial SH3 domain; Region: SH3_5; pfam08460 869309006222 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 869309006223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 869309006224 replicative DNA helicase; Provisional; Region: PRK05748 869309006225 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 869309006226 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 869309006227 Walker A motif; other site 869309006228 ATP binding site [chemical binding]; other site 869309006229 Walker B motif; other site 869309006230 DNA binding loops [nucleotide binding] 869309006231 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 869309006232 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 869309006233 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 869309006234 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 869309006235 DHH family; Region: DHH; pfam01368 869309006236 DHHA1 domain; Region: DHHA1; pfam02272 869309006237 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 869309006238 30S subunit binding site; other site 869309006239 comF family protein; Region: comF; TIGR00201 869309006240 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 869309006241 active site 869309006242 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 869309006243 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 869309006244 ATP binding site [chemical binding]; other site 869309006245 putative Mg++ binding site [ion binding]; other site 869309006246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 869309006247 nucleotide binding region [chemical binding]; other site 869309006248 ATP-binding site [chemical binding]; other site 869309006249 Uncharacterized conserved protein [Function unknown]; Region: COG1739 869309006250 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 869309006251 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 869309006252 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 869309006253 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 869309006254 dimer interface [polypeptide binding]; other site 869309006255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 869309006256 catalytic residue [active] 869309006258 elongation factor Ts; Provisional; Region: tsf; PRK09377 869309006259 UBA/TS-N domain; Region: UBA; pfam00627 869309006260 Elongation factor TS; Region: EF_TS; pfam00889 869309006261 Elongation factor TS; Region: EF_TS; pfam00889 869309006262 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 869309006263 rRNA interaction site [nucleotide binding]; other site 869309006264 S8 interaction site; other site 869309006265 putative laminin-1 binding site; other site 869309006266 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 869309006267 Septum formation initiator; Region: DivIC; cl17659 869309006268 Surface antigen [General function prediction only]; Region: COG3942 869309006269 CHAP domain; Region: CHAP; pfam05257 869309006270 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 869309006271 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 869309006272 rod shape-determining protein MreC; Region: MreC; pfam04085 869309006273 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 869309006274 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 869309006275 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869309006276 Walker A/P-loop; other site 869309006277 ATP binding site [chemical binding]; other site 869309006278 Q-loop/lid; other site 869309006279 ABC transporter signature motif; other site 869309006280 Walker B; other site 869309006281 D-loop; other site 869309006282 H-loop/switch region; other site 869309006283 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 869309006284 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 869309006285 Walker A/P-loop; other site 869309006286 ATP binding site [chemical binding]; other site 869309006287 Q-loop/lid; other site 869309006288 ABC transporter signature motif; other site 869309006289 Walker B; other site 869309006290 D-loop; other site 869309006291 H-loop/switch region; other site 869309006292 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 869309006293 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 869309006294 Helix-turn-helix domain; Region: HTH_25; pfam13413 869309006295 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 869309006296 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869309006297 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 869309006298 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869309006299 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 869309006300 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 869309006301 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 869309006302 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 869309006303 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 869309006304 Walker A/P-loop; other site 869309006305 ATP binding site [chemical binding]; other site 869309006306 Q-loop/lid; other site 869309006307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 869309006308 ABC transporter signature motif; other site 869309006309 Walker B; other site 869309006310 D-loop; other site 869309006311 H-loop/switch region; other site 869309006312 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 869309006313 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 869309006314 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 869309006315 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 869309006316 active site 869309006317 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 869309006318 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 869309006319 active site 869309006320 HIGH motif; other site 869309006321 dimer interface [polypeptide binding]; other site 869309006322 KMSKS motif; other site 869309006323 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869309006324 ABC transporter; Region: ABC_tran_2; pfam12848 869309006325 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 869309006326 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 869309006327 Predicted membrane protein [Function unknown]; Region: COG4485 869309006328 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 869309006329 Predicted membrane protein [Function unknown]; Region: COG1511 869309006330 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 869309006331 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 869309006332 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 869309006333 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 869309006334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 869309006335 active site 869309006336 phosphorylation site [posttranslational modification] 869309006337 intermolecular recognition site; other site 869309006338 dimerization interface [polypeptide binding]; other site 869309006339 LytTr DNA-binding domain; Region: LytTR; pfam04397 869309006341 COMC family; Region: ComC; pfam03047 869309006342 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 869309006343 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 869309006344 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 869309006345 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 869309006346 protein binding site [polypeptide binding]; other site 869309006347 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 869309006348 ParB-like nuclease domain; Region: ParBc; pfam02195 869309006349 KorB domain; Region: KorB; pfam08535