-- dump date 20140620_085418 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type NP_344554.1 15899950 929738 197..1558 1 NC_003028.3 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosome replication initiator DnaA 1558 dnaA 929738 dnaA Streptococcus pneumoniae TIGR4 chromosome replication initiator DnaA NP_344554.1 197 D 170187 CDS NP_344555.1 15899951 929739 1717..2853 1 NC_003028.3 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2853 929739 SP_0002 Streptococcus pneumoniae TIGR4 DNA polymerase III subunit beta NP_344555.1 1717 D 170187 CDS NP_344556.1 15899952 929740 2864..3112 1 NC_003028.3 hypothetical protein 3112 929740 SP_0003 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344556.1 2864 D 170187 CDS NP_344557.1 15899953 929741 3196..4311 1 NC_003028.3 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 4311 929741 SP_0004 Streptococcus pneumoniae TIGR4 GTP-dependent nucleic acid-binding protein EngD NP_344557.1 3196 D 170187 CDS NP_344558.1 15899954 929742 4382..4951 1 NC_003028.3 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4951 929742 SP_0005 Streptococcus pneumoniae TIGR4 peptidyl-tRNA hydrolase NP_344558.1 4382 D 170187 CDS NP_344559.1 15899955 929743 4952..8461 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00580; transcription-repair coupling factor 8461 929743 SP_0006 Streptococcus pneumoniae TIGR4 transcription-repair coupling factor NP_344559.1 4952 D 170187 CDS NP_344560.1 15899956 929744 8519..8785 1 NC_003028.3 S4 domain-containing protein 8785 929744 SP_0007 Streptococcus pneumoniae TIGR4 S4 domain-containing protein NP_344560.1 8519 D 170187 CDS NP_344561.1 15899957 929745 8778..9146 1 NC_003028.3 hypothetical protein 9146 929745 SP_0008 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344561.1 8778 D 170187 CDS NP_344562.1 15899958 929746 9151..9273 1 NC_003028.3 hypothetical protein 9273 929746 SP_0009 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344562.1 9151 D 170187 CDS NP_344563.1 15899959 929747 9266..10534 1 NC_003028.3 similar to PID:683698; identified by sequence similarity; hypothetical protein 10534 929747 SP_0010 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344563.1 9266 D 170187 CDS NP_344564.1 15899960 929748 10531..11808 1 NC_003028.3 MesJ/Ycf62 family protein 11808 929748 SP_0011 Streptococcus pneumoniae TIGR4 MesJ/Ycf62 family protein NP_344564.1 10531 D 170187 CDS NP_344565.1 15899961 929749 11812..12354 1 NC_003028.3 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 12354 929749 SP_0012 Streptococcus pneumoniae TIGR4 hypoxanthine-guanine phosphoribosyltransferase NP_344565.1 11812 D 170187 CDS NP_344566.1 15899962 929750 12370..14328 1 NC_003028.3 identified by match to PFAM protein family HMM PF01434; cell division protein FtsH 14328 929750 SP_0013 Streptococcus pneumoniae TIGR4 cell division protein FtsH NP_344566.1 12370 D 170187 CDS NP_344567.1 15899963 929752 14450..14929 1 NC_003028.3 similar to GP:5739312; identified by sequence similarity; transcriptional regulator ComX1 14929 929752 SP_0014 Streptococcus pneumoniae TIGR4 transcriptional regulator ComX1 NP_344567.1 14450 D 170187 CDS NP_344568.1 15899964 929762 20404..20820 1 NC_003028.3 IS630-Spn1, transposase Orf1 20820 929762 SP_0015 Streptococcus pneumoniae TIGR4 IS630-Spn1, transposase Orf1 NP_344568.1 20404 D 170187 CDS NP_344569.1 15899965 929763 20929..21267 1 NC_003028.3 IS630-Spn1, transposase Orf2 21267 929763 SP_0016 Streptococcus pneumoniae TIGR4 IS630-Spn1, transposase Orf2 NP_344569.1 20929 D 170187 CDS NP_344570.1 15899966 929765 22359..22601 1 NC_003028.3 hypothetical protein 22601 929765 SP_0018 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344570.1 22359 D 170187 CDS NP_344571.1 15899967 929766 22832..24118 1 NC_003028.3 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 24118 929766 SP_0019 Streptococcus pneumoniae TIGR4 adenylosuccinate synthetase NP_344571.1 22832 D 170187 CDS NP_344572.1 15899968 929767 24319..24786 1 NC_003028.3 cytidine/deoxycytidylate deaminase 24786 929767 SP_0020 Streptococcus pneumoniae TIGR4 cytidine/deoxycytidylate deaminase NP_344572.1 24319 D 170187 CDS NP_344573.1 15899969 929768 24973..25416 1 NC_003028.3 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 25416 dut 929768 dut Streptococcus pneumoniae TIGR4 deoxyuridine 5'-triphosphate nucleotidohydrolase NP_344573.1 24973 D 170187 CDS NP_344574.1 15899970 929769 25418..25933 1 NC_003028.3 hypothetical protein 25933 929769 SP_0022 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344574.1 25418 D 170187 CDS NP_344575.1 15899971 929771 27381..27878 1 NC_003028.3 hypothetical protein 27878 929771 SP_0024 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344575.1 27381 D 170187 CDS NP_344576.1 15899972 929772 27903..28112 1 NC_003028.3 hypothetical protein 28112 929772 SP_0025 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344576.1 27903 D 170187 CDS NP_344577.1 15899973 929773 28094..28717 1 NC_003028.3 hypothetical protein 28717 929773 SP_0026 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344577.1 28094 D 170187 CDS NP_344578.1 15899974 929774 28862..29830 1 NC_003028.3 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 29830 929774 SP_0027 Streptococcus pneumoniae TIGR4 ribose-phosphate pyrophosphokinase NP_344578.1 28862 D 170187 CDS NP_344579.1 15899975 929776 complement(30372..30605) 1 NC_003028.3 hypothetical protein 30605 929776 SP_0029 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344579.1 30372 R 170187 CDS NP_344580.1 15899976 929777 complement(30563..30889) 1 NC_003028.3 similar to GP:1469653; identified by sequence similarity; competence-induced protein Ccs16 30889 929777 SP_0030 Streptococcus pneumoniae TIGR4 competence-induced protein Ccs16 NP_344580.1 30563 R 170187 CDS NP_344581.1 15899977 929778 complement(30929..31243) 1 NC_003028.3 hypothetical protein 31243 929778 SP_0031 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344581.1 30929 R 170187 CDS NP_344582.1 15899978 929779 31535..34168 1 NC_003028.3 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 34168 929779 SP_0032 Streptococcus pneumoniae TIGR4 DNA polymerase I NP_344582.1 31535 D 170187 CDS NP_344583.1 15899979 929780 34253..34690 1 NC_003028.3 hypothetical protein 34690 929780 SP_0033 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344583.1 34253 D 170187 CDS NP_344584.1 15899980 929781 complement(35009..36019) 1 NC_003028.3 hypothetical protein 36019 929781 SP_0034 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344584.1 35009 R 170187 CDS NP_344585.1 15899981 929782 36168..37337 1 NC_003028.3 catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 37337 929782 SP_0035 Streptococcus pneumoniae TIGR4 aromatic amino acid aminotransferase NP_344585.1 36168 D 170187 CDS NP_344586.1 15899982 929785 37334..38104 1 NC_003028.3 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 38104 recO 929785 recO Streptococcus pneumoniae TIGR4 DNA repair protein RecO NP_344586.1 37334 D 170187 CDS NP_344587.1 15899983 929786 38101..39093 1 NC_003028.3 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 39093 929786 SP_0037 Streptococcus pneumoniae TIGR4 glycerol-3-phosphate acyltransferase PlsX NP_344587.1 38101 D 170187 CDS NP_344588.1 15899984 929788 39099..39332 1 NC_003028.3 identified by match to PFAM protein family HMM PF00550; acyl carrier protein 39332 929788 SP_0038 Streptococcus pneumoniae TIGR4 acyl carrier protein NP_344588.1 39099 D 170187 CDS NP_344589.1 15899985 929790 complement(39716..39841) 1 NC_003028.3 hypothetical protein 39841 929790 SP_0040 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344589.1 39716 R 170187 CDS NP_344590.1 15899986 929791 39871..40101 1 NC_003028.3 similar to GP:9798576; identified by sequence similarity; bacteriocin BlpU 40101 929791 SP_0041 Streptococcus pneumoniae TIGR4 bacteriocin BlpU NP_344590.1 39871 D 170187 CDS NP_344591.1 15899987 929792 40816..42969 1 NC_003028.3 competence factor transporting ATP-binding protein/permease ComA 42969 929792 SP_0042 Streptococcus pneumoniae TIGR4 competence factor transporting ATP-binding protein/permease ComA NP_344591.1 40816 D 170187 CDS NP_344592.1 15899988 929793 42982..44331 1 NC_003028.3 competence factor transport protein ComB 44331 929793 SP_0043 Streptococcus pneumoniae TIGR4 competence factor transport protein ComB NP_344592.1 42982 D 170187 CDS NP_344593.1 15899989 929794 44501..45208 1 NC_003028.3 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 45208 929794 SP_0044 Streptococcus pneumoniae TIGR4 phosphoribosylaminoimidazole-succinocarboxamide synthase NP_344593.1 44501 D 170187 CDS NP_344594.1 15899990 929795 45410..49135 1 NC_003028.3 identified by match to PFAM protein family HMM PF00586; phosphoribosylformylglycinamidine synthase 49135 929795 SP_0045 Streptococcus pneumoniae TIGR4 phosphoribosylformylglycinamidine synthase NP_344594.1 45410 D 170187 CDS NP_344595.1 15899991 929796 49228..50670 1 NC_003028.3 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 50670 929796 SP_0046 Streptococcus pneumoniae TIGR4 amidophosphoribosyltransferase NP_344595.1 49228 D 170187 CDS NP_344596.1 15899992 929797 50889..51911 1 NC_003028.3 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 51911 929797 SP_0047 Streptococcus pneumoniae TIGR4 phosphoribosylaminoimidazole synthetase NP_344596.1 50889 D 170187 CDS NP_344597.1 15899993 929798 51908..52453 1 NC_003028.3 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 52453 purN 929798 purN Streptococcus pneumoniae TIGR4 phosphoribosylglycinamide formyltransferase NP_344597.1 51908 D 170187 CDS NP_344598.1 15899994 929801 52537..53046 1 NC_003028.3 similar to GP:6448500; identified by sequence similarity; vanZ protein 53046 929801 SP_0049 Streptococcus pneumoniae TIGR4 vanZ protein NP_344598.1 52537 D 170187 CDS NP_344599.1 15899995 929804 53071..54618 1 NC_003028.3 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 54618 purH 929804 purH Streptococcus pneumoniae TIGR4 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase NP_344599.1 53071 D 170187 CDS NP_344600.1 15899996 929805 54740..56002 1 NC_003028.3 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 56002 929805 SP_0051 Streptococcus pneumoniae TIGR4 phosphoribosylamine--glycine ligase NP_344600.1 54740 D 170187 CDS NP_344601.1 15899997 929806 56259..56375 1 NC_003028.3 hypothetical protein 56375 929806 SP_0052 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344601.1 56259 D 170187 CDS NP_344602.1 15899998 929808 56405..56893 1 NC_003028.3 Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit 56893 929808 SP_0053 Streptococcus pneumoniae TIGR4 phosphoribosylaminoimidazole carboxylase catalytic subunit NP_344602.1 56405 D 170187 CDS NP_344603.1 15899999 929809 56880..57971 1 NC_003028.3 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 57971 929809 SP_0054 Streptococcus pneumoniae TIGR4 phosphoribosylaminoimidazole carboxylase ATPase subunit NP_344603.1 56880 D 170187 CDS NP_344604.1 15900000 929810 57981..58208 1 NC_003028.3 hypothetical protein 58208 929810 SP_0055 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344604.1 57981 D 170187 CDS NP_344605.1 15900001 929811 58271..59569 1 NC_003028.3 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 59569 929811 SP_0056 Streptococcus pneumoniae TIGR4 adenylosuccinate lyase NP_344605.1 58271 D 170187 CDS NP_344606.1 15900002 929812 complement(59624..63562) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00746; beta-N-acetylhexosaminidase 63562 929812 SP_0057 Streptococcus pneumoniae TIGR4 beta-N-acetylhexosaminidase NP_344606.1 59624 R 170187 CDS NP_344607.1 15900003 929814 complement(63890..64606) 1 NC_003028.3 GntR family transcriptional regulator 64606 929814 SP_0058 Streptococcus pneumoniae TIGR4 GntR family transcriptional regulator NP_344607.1 63890 R 170187 CDS NP_344608.1 15900004 929815 64593..64694 1 NC_003028.3 hypothetical protein 64694 929815 SP_0059 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344608.1 64593 D 170187 CDS NP_344609.1 15900005 929817 64955..66742 1 NC_003028.3 identified by match to PFAM protein family HMM PF01301; Beta-galactosidase 3 66742 929817 SP_0060 Streptococcus pneumoniae TIGR4 Beta-galactosidase 3 NP_344609.1 64955 D 170187 CDS NP_344610.1 15900006 929820 66739..67215 1 NC_003028.3 PTS system transporter subunit IIB 67215 929820 SP_0061 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIB NP_344610.1 66739 D 170187 CDS NP_344611.1 15900007 929821 67243..68148 1 NC_003028.3 PTS system transporter subunit IIC 68148 929821 SP_0062 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIC NP_344611.1 67243 D 170187 CDS NP_344612.1 15900008 929823 68135..68950 1 NC_003028.3 PTS system transporter subunit IID 68950 929823 SP_0063 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IID NP_344612.1 68135 D 170187 CDS NP_344613.1 15900009 929825 68957..69361 1 NC_003028.3 PTS system transporter subunit IIA 69361 929825 SP_0064 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIA NP_344613.1 68957 D 170187 CDS NP_344614.1 15900010 929827 69660..70826 1 NC_003028.3 sugar isomerase 70826 929827 SP_0065 Streptococcus pneumoniae TIGR4 sugar isomerase NP_344614.1 69660 D 170187 CDS NP_344615.1 15900011 929828 70942..71979 1 NC_003028.3 identified by match to PFAM protein family HMM PF01263; aldose 1-epimerase 71979 929828 SP_0066 Streptococcus pneumoniae TIGR4 aldose 1-epimerase NP_344615.1 70942 D 170187 CDS NP_344616.1 15900012 929829 72141..72401 1 NC_003028.3 hypothetical protein 72401 929829 SP_0067 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344616.1 72141 D 170187 CDS NP_344617.1 15900013 929830 72456..72653 1 NC_003028.3 hypothetical protein 72653 929830 SP_0068 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344617.1 72456 D 170187 CDS NP_344618.1 15900014 929834 72674..73309 1 NC_003028.3 choline binding protein I 73309 929834 SP_0069 Streptococcus pneumoniae TIGR4 choline binding protein I NP_344618.1 72674 D 170187 CDS NP_344619.1 15900015 929835 73353..73454 1 NC_003028.3 hypothetical protein 73454 929835 SP_0070 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344619.1 73353 D 170187 CDS NP_344620.1 15900016 929838 73761..79331 1 NC_003028.3 immunoglobulin A1 protease 79331 929838 SP_0071 Streptococcus pneumoniae TIGR4 immunoglobulin A1 protease NP_344620.1 73761 D 170187 CDS NP_344621.1 15900017 929839 79434..79547 1 NC_003028.3 hypothetical protein 79547 929839 SP_0072 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344621.1 79434 D 170187 CDS NP_344622.1 15900018 929841 79687..80541 1 NC_003028.3 hypothetical protein 80541 929841 SP_0073 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344622.1 79687 D 170187 CDS NP_344623.1 15900019 929842 80647..81204 1 NC_003028.3 acetyltransferase 81204 929842 SP_0074 Streptococcus pneumoniae TIGR4 acetyltransferase NP_344623.1 80647 D 170187 CDS NP_344624.1 15900020 929844 81481..82185 1 NC_003028.3 identified by match to PFAM protein family HMM PF01048; phosphorylase Pnp/Udp family protein 82185 929844 SP_0075 Streptococcus pneumoniae TIGR4 phosphorylase Pnp/Udp family protein NP_344624.1 81481 D 170187 CDS NP_344625.1 15900021 929845 complement(82590..82682) 1 NC_003028.3 hypothetical protein 82682 929845 SP_0076 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344625.1 82590 R 170187 CDS NP_344626.1 15900022 929846 82659..82817 1 NC_003028.3 hypothetical protein 82817 929846 SP_0077 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344626.1 82659 D 170187 CDS NP_344627.1 15900023 929848 82798..84177 1 NC_003028.3 Trk family potassium uptake protein 84177 929848 SP_0078 Streptococcus pneumoniae TIGR4 Trk family potassium uptake protein NP_344627.1 82798 D 170187 CDS NP_344628.1 15900024 929849 84191..84856 1 NC_003028.3 identified by match to PFAM protein family HMM PF02254; Trk family potassium uptake protein 84856 929849 SP_0079 Streptococcus pneumoniae TIGR4 Trk family potassium uptake protein NP_344628.1 84191 D 170187 CDS NP_344629.1 15900025 929850 84877..84984 1 NC_003028.3 hypothetical protein 84984 929850 SP_0080 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344629.1 84877 D 170187 CDS NP_344630.1 15900026 929852 86298..88871 1 NC_003028.3 identified by match to PFAM protein family HMM PF00746; cell wall surface anchor family protein 88871 929852 SP_0082 Streptococcus pneumoniae TIGR4 cell wall surface anchor family protein NP_344630.1 86298 D 170187 CDS NP_344631.1 15900027 929853 89038..89736 1 NC_003028.3 DNA-binding response regulator 89736 929853 SP_0083 Streptococcus pneumoniae TIGR4 DNA-binding response regulator NP_344631.1 89038 D 170187 CDS NP_344632.1 15900028 929854 89733..90785 1 NC_003028.3 sensor histidine kinase 90785 929854 SP_0084 Streptococcus pneumoniae TIGR4 sensor histidine kinase NP_344632.1 89733 D 170187 CDS NP_344633.1 15900029 929855 90980..91591 1 NC_003028.3 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 91591 rpsD 929855 rpsD Streptococcus pneumoniae TIGR4 30S ribosomal protein S4 NP_344633.1 90980 D 170187 CDS NP_344634.1 15900030 929858 complement(92025..92165) 1 NC_003028.3 hypothetical protein 92165 929858 SP_0087 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344634.1 92025 R 170187 CDS NP_344635.1 15900031 929859 92236..92505 1 NC_003028.3 hypothetical protein 92505 929859 SP_0088 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344635.1 92236 D 170187 CDS NP_344636.1 15900032 929860 92585..92680 1 NC_003028.3 hypothetical protein 92680 929860 SP_0089 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344636.1 92585 D 170187 CDS NP_344637.1 15900033 929861 92969..93928 1 NC_003028.3 ABC transporter permease 93928 929861 SP_0090 Streptococcus pneumoniae TIGR4 ABC transporter permease NP_344637.1 92969 D 170187 CDS NP_344638.1 15900034 929863 93942..94865 1 NC_003028.3 ABC transporter permease 94865 929863 SP_0091 Streptococcus pneumoniae TIGR4 ABC transporter permease NP_344638.1 93942 D 170187 CDS NP_344639.1 15900035 929866 95123..96598 1 NC_003028.3 ABC transporter substrate-binding protein 96598 929866 SP_0092 Streptococcus pneumoniae TIGR4 ABC transporter substrate-binding protein NP_344639.1 95123 D 170187 CDS NP_344640.1 15900036 929867 complement(96628..96741) 1 NC_003028.3 hypothetical protein 96741 929867 SP_0093 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344640.1 96628 R 170187 CDS NP_344641.1 15900037 929868 96713..96820 1 NC_003028.3 hypothetical protein 96820 929868 SP_0094 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344641.1 96713 D 170187 CDS NP_344642.1 15900038 929869 96870..97856 1 NC_003028.3 hypothetical protein 97856 929869 SP_0095 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344642.1 96870 D 170187 CDS NP_344643.1 15900039 929870 98131..98991 1 NC_003028.3 hypothetical protein 98991 929870 SP_0096 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344643.1 98131 D 170187 CDS NP_344644.1 15900040 929872 complement(99169..100233) 1 NC_003028.3 similar to GP:8953759; identified by sequence similarity; hypothetical protein 100233 929872 SP_0097 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344644.1 99169 R 170187 CDS NP_344645.1 15900041 929873 complement(100296..101207) 1 NC_003028.3 hypothetical protein 101207 929873 SP_0098 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344645.1 100296 R 170187 CDS NP_344646.1 15900042 929874 complement(101200..101793) 1 NC_003028.3 hypothetical protein 101793 929874 SP_0099 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344646.1 101200 R 170187 CDS NP_344647.1 15900043 929875 complement(101780..102106) 1 NC_003028.3 hypothetical protein 102106 929875 SP_0100 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344647.1 101780 R 170187 CDS NP_344648.1 15900044 929876 complement(102245..103411) 1 NC_003028.3 transporter 103411 929876 SP_0101 Streptococcus pneumoniae TIGR4 transporter NP_344648.1 102245 R 170187 CDS NP_344649.1 15900045 929877 103562..104626 1 NC_003028.3 glycosyl transferase family protein 104626 929877 SP_0102 Streptococcus pneumoniae TIGR4 glycosyl transferase family protein NP_344649.1 103562 D 170187 CDS NP_344650.1 15900046 929878 104668..106518 1 NC_003028.3 capsular polysaccharide biosynthesis protein 106518 929878 SP_0103 Streptococcus pneumoniae TIGR4 capsular polysaccharide biosynthesis protein NP_344650.1 104668 D 170187 CDS NP_344651.1 15900047 929880 complement(106956..107588) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00702; HAD superfamily hydrolase 107588 929880 SP_0104 Streptococcus pneumoniae TIGR4 HAD superfamily hydrolase NP_344651.1 106956 R 170187 CDS NP_344652.1 15900048 929882 complement(107610..108482) 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00718; L-serine dehydratase, iron-sulfur-dependent subunit alpha 108482 929882 SP_0105 Streptococcus pneumoniae TIGR4 L-serine dehydratase, iron-sulfur-dependent subunit alpha NP_344652.1 107610 R 170187 CDS NP_344653.1 15900049 929883 complement(108491..109162) 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00719; L-serine dehydratase, iron-sulfur-dependent subunit beta 109162 929883 SP_0106 Streptococcus pneumoniae TIGR4 L-serine dehydratase, iron-sulfur-dependent subunit beta NP_344653.1 108491 R 170187 CDS NP_344654.1 15900050 929884 109404..109991 1 NC_003028.3 LysM domain-containing protein 109991 929884 SP_0107 Streptococcus pneumoniae TIGR4 LysM domain-containing protein NP_344654.1 109404 D 170187 CDS NP_344655.1 15900051 929885 complement(110043..110363) 1 NC_003028.3 hypothetical protein 110363 929885 SP_0108 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344655.1 110043 R 170187 CDS NP_344656.1 15900052 929886 110794..111081 1 NC_003028.3 similar to GP:3355782; identified by sequence similarity; bacteriocin 111081 929886 SP_0109 Streptococcus pneumoniae TIGR4 bacteriocin NP_344656.1 110794 D 170187 CDS NP_344657.1 15900053 929888 111157..113241 1 NC_003028.3 hypothetical protein 113241 929888 SP_0110 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344657.1 111157 D 170187 CDS NP_344658.1 15900054 929889 113238..113879 1 NC_003028.3 amino acid ABC transporter ATP-binding protein 113879 929889 SP_0111 Streptococcus pneumoniae TIGR4 amino acid ABC transporter ATP-binding protein NP_344658.1 113238 D 170187 CDS NP_344659.1 15900055 929890 114086..114892 1 NC_003028.3 amino acid ABC transporter substrate-binding protein 114892 929890 SP_0112 Streptococcus pneumoniae TIGR4 amino acid ABC transporter substrate-binding protein NP_344659.1 114086 D 170187 CDS NP_344660.1 15900056 929892 complement(115515..115835) 1 NC_003028.3 hypothetical protein 115835 929892 SP_0114 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344660.1 115515 R 170187 CDS NP_344661.1 15900057 929893 116593..116973 1 NC_003028.3 hypothetical protein 116973 929893 SP_0115 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344661.1 116593 D 170187 CDS NP_344662.1 15900058 929894 117625..117870 1 NC_003028.3 hypothetical protein 117870 929894 SP_0116 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344662.1 117625 D 170187 CDS NP_344663.1 15900059 929896 118423..120657 1 NC_003028.3 surface protein A 120657 929896 SP_0117 Streptococcus pneumoniae TIGR4 surface protein A NP_344663.1 118423 D 170187 CDS NP_344664.1 15900060 929897 121058..122179 1 NC_003028.3 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 122179 mnmA 929897 mnmA Streptococcus pneumoniae TIGR4 tRNA-specific 2-thiouridylase MnmA NP_344664.1 121058 D 170187 CDS NP_344665.1 15900061 929898 122320..122775 1 NC_003028.3 MutT/nudix family protein 122775 929898 SP_0119 Streptococcus pneumoniae TIGR4 MutT/nudix family protein NP_344665.1 122320 D 170187 CDS NP_344666.1 15900062 929899 122785..124698 1 NC_003028.3 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 124698 929899 SP_0120 Streptococcus pneumoniae TIGR4 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA NP_344666.1 122785 D 170187 CDS NP_344667.1 15900063 929900 complement(125051..126730) 1 NC_003028.3 identified by match to PFAM protein family HMM PF02147; metallo-beta-lactamase superfamily protein 126730 929900 SP_0121 Streptococcus pneumoniae TIGR4 metallo-beta-lactamase superfamily protein NP_344667.1 125051 R 170187 CDS NP_344668.1 15900064 929901 complement(126732..126965) 1 NC_003028.3 hypothetical protein 126965 929901 SP_0122 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344668.1 126732 R 170187 CDS NP_344669.1 15900065 929902 complement(127291..127536) 1 NC_003028.3 similar to SP:P39554 PID:456140; identified by sequence similarity; competence-induced protein Ccs1 127536 929902 SP_0123 Streptococcus pneumoniae TIGR4 competence-induced protein Ccs1 NP_344669.1 127291 R 170187 CDS NP_344670.1 15900066 929905 complement(127783..127935) 1 NC_003028.3 hypothetical protein 127935 929905 SP_0124 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344670.1 127783 R 170187 CDS NP_344671.1 15900067 929906 complement(127937..128122) 1 NC_003028.3 hypothetical protein 128122 929906 SP_0125 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344671.1 127937 R 170187 CDS NP_344672.1 15900068 929907 128097..128204 1 NC_003028.3 hypothetical protein 128204 929907 SP_0126 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344672.1 128097 D 170187 CDS NP_344673.1 15900069 929908 128300..128983 1 NC_003028.3 hypothetical protein 128983 929908 SP_0127 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344673.1 128300 D 170187 CDS NP_344674.1 15900070 929911 128980..129417 1 NC_003028.3 ribosomal-protein-alanine acetyltransferase 129417 929911 SP_0128 Streptococcus pneumoniae TIGR4 ribosomal-protein-alanine acetyltransferase NP_344674.1 128980 D 170187 CDS NP_344675.1 15900071 929912 129407..130417 1 NC_003028.3 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 130417 929912 SP_0129 Streptococcus pneumoniae TIGR4 DNA-binding/iron metalloprotein/AP endonuclease NP_344675.1 129407 D 170187 CDS NP_344676.1 15900072 929918 133024..133587 1 NC_003028.3 hypothetical protein 133587 929918 SP_0133 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344676.1 133024 D 170187 CDS NP_344677.1 15900073 929920 133565..133771 1 NC_003028.3 hypothetical protein 133771 929920 SP_0134 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344677.1 133565 D 170187 CDS NP_344678.1 15900074 929921 133795..134238 1 NC_003028.3 glycosyl transferase family protein 134238 929921 SP_0135 Streptococcus pneumoniae TIGR4 glycosyl transferase family protein NP_344678.1 133795 D 170187 CDS NP_344679.1 15900075 929922 134231..135106 1 NC_003028.3 glycosyl transferase family protein 135106 929922 SP_0136 Streptococcus pneumoniae TIGR4 glycosyl transferase family protein NP_344679.1 134231 D 170187 CDS NP_344680.1 15900076 929923 135193..136809 1 NC_003028.3 ABC transporter ATP-binding protein 136809 929923 SP_0137 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_344680.1 135193 D 170187 CDS NP_344681.1 15900077 929924 137031..137498 1 NC_003028.3 hypothetical protein 137498 929924 SP_0138 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344681.1 137031 D 170187 CDS NP_344682.1 15900078 929926 137504..138259 1 NC_003028.3 similar to GP:4689219; identified by sequence similarity; hypothetical protein 138259 929926 SP_0139 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344682.1 137504 D 170187 CDS NP_344683.1 15900079 929928 139839..140702 1 NC_003028.3 transcriptional regulator 140702 929928 SP_0141 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_344683.1 139839 D 170187 CDS NP_344684.1 15900080 929930 140988..141221 1 NC_003028.3 hypothetical protein 141221 929930 SP_0142 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344684.1 140988 D 170187 CDS NP_344685.1 15900081 929931 141243..141920 1 NC_003028.3 similar to GB:AL009126; identified by sequence similarity; hypothetical protein 141920 929931 SP_0143 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344685.1 141243 D 170187 CDS NP_344686.1 15900082 929932 141932..142597 1 NC_003028.3 hypothetical protein 142597 929932 SP_0144 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344686.1 141932 D 170187 CDS NP_344687.1 15900083 929933 142669..143895 1 NC_003028.3 hypothetical protein 143895 929933 SP_0145 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344687.1 142669 D 170187 CDS NP_344688.1 15900084 929934 144440..145096 1 NC_003028.3 hypothetical protein 145096 929934 SP_0146 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344688.1 144440 D 170187 CDS NP_344689.1 15900085 929935 145086..145295 1 NC_003028.3 hypothetical protein 145295 929935 SP_0147 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344689.1 145086 D 170187 CDS NP_344690.1 15900086 929936 145513..146343 1 NC_003028.3 ABC transporter substrate-binding protein 146343 929936 SP_0148 Streptococcus pneumoniae TIGR4 ABC transporter substrate-binding protein NP_344690.1 145513 D 170187 CDS NP_344691.1 15900087 929937 146497..147351 1 NC_003028.3 lipoprotein 147351 929937 SP_0149 Streptococcus pneumoniae TIGR4 lipoprotein NP_344691.1 146497 D 170187 CDS NP_344692.1 15900088 929938 147451..148824 1 NC_003028.3 hypothetical protein 148824 929938 SP_0150 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344692.1 147451 D 170187 CDS NP_344693.1 15900089 929939 148817..149878 1 NC_003028.3 ABC transporter ATP-binding protein 149878 929939 SP_0151 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_344693.1 148817 D 170187 CDS NP_344694.1 15900090 929940 149880..150572 1 NC_003028.3 ABC transporter permease 150572 929940 SP_0152 Streptococcus pneumoniae TIGR4 ABC transporter permease NP_344694.1 149880 D 170187 CDS NP_344695.1 15900091 929941 complement(150602..151171) 1 NC_003028.3 hypothetical protein 151171 929941 SP_0153 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344695.1 150602 R 170187 CDS NP_344696.1 15900092 929942 151306..151920 1 NC_003028.3 hypothetical protein 151920 929942 SP_0154 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344696.1 151306 D 170187 CDS NP_344697.1 15900093 929945 151922..153568 1 NC_003028.3 sensor histidine kinase 153568 929945 SP_0155 Streptococcus pneumoniae TIGR4 sensor histidine kinase NP_344697.1 151922 D 170187 CDS NP_344698.1 15900094 929947 153580..154866 1 NC_003028.3 DNA-binding response regulator 154866 929947 SP_0156 Streptococcus pneumoniae TIGR4 DNA-binding response regulator NP_344698.1 153580 D 170187 CDS NP_344699.1 15900095 929948 154870..155451 1 NC_003028.3 hypothetical protein 155451 929948 SP_0157 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344699.1 154870 D 170187 CDS NP_344700.1 15900096 929949 155529..155999 1 NC_003028.3 has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; flavoprotein NrdI 155999 929949 SP_0158 Streptococcus pneumoniae TIGR4 flavoprotein NrdI NP_344700.1 155529 D 170187 CDS NP_344701.1 15900097 929950 complement(156292..157554) 1 NC_003028.3 hypothetical protein 157554 929950 SP_0159 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344701.1 156292 R 170187 CDS NP_344702.1 15900098 929951 complement(157864..158322) 1 NC_003028.3 similar to GP:6690328; identified by sequence similarity; hypothetical protein 158322 929951 SP_0160 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344702.1 157864 R 170187 CDS NP_344703.1 15900099 929952 complement(158319..158759) 1 NC_003028.3 similar to PID:1196936; identified by sequence similarity; hypothetical protein 158759 929952 SP_0161 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344703.1 158319 R 170187 CDS NP_344704.1 15900100 929953 158849..158944 1 NC_003028.3 hypothetical protein 158944 929953 SP_0162 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344704.1 158849 D 170187 CDS NP_344705.1 15900101 929954 159192..160058 1 NC_003028.3 transcriptional regulator PlcR 160058 929954 SP_0163 Streptococcus pneumoniae TIGR4 transcriptional regulator PlcR NP_344705.1 159192 D 170187 CDS NP_344706.1 15900102 929955 160211..160339 1 NC_003028.3 hypothetical protein 160339 929955 SP_0164 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344706.1 160211 D 170187 CDS NP_344707.1 15900103 929956 160384..160941 1 NC_003028.3 similar to SP:P30197 GB:X62386 PID:46970; identified by sequence similarity; flavoprotein 160941 929956 SP_0165 Streptococcus pneumoniae TIGR4 flavoprotein NP_344707.1 160384 D 170187 CDS NP_344708.1 15900104 929958 161162..162268 1 NC_003028.3 pyridoxal-dependent decarboxylase 162268 929958 SP_0166 Streptococcus pneumoniae TIGR4 pyridoxal-dependent decarboxylase NP_344708.1 161162 D 170187 CDS NP_344709.1 15900105 929959 162244..163635 1 NC_003028.3 hypothetical protein 163635 929959 SP_0167 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344709.1 162244 D 170187 CDS NP_344710.1 15900106 929960 163632..164810 1 NC_003028.3 macrolide efflux protein 164810 929960 SP_0168 Streptococcus pneumoniae TIGR4 macrolide efflux protein NP_344710.1 163632 D 170187 CDS NP_344711.1 15900107 929962 165095..165211 1 NC_003028.3 hypothetical protein 165211 929962 SP_0170 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344711.1 165095 D 170187 CDS NP_344712.1 15900108 929963 165235..165468 1 NC_003028.3 ROK family protein 165468 929963 SP_0171 Streptococcus pneumoniae TIGR4 ROK family protein NP_344712.1 165235 D 170187 CDS NP_344713.1 15900109 929964 165586..165690 1 NC_003028.3 hypothetical protein 165690 929964 SP_0172 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344713.1 165586 D 170187 CDS NP_344714.1 15900110 929965 165751..167700 1 NC_003028.3 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 167700 mutL 929965 mutL Streptococcus pneumoniae TIGR4 DNA mismatch repair protein NP_344714.1 165751 D 170187 CDS NP_344715.1 15900111 929966 complement(167836..167928) 1 NC_003028.3 hypothetical protein 167928 929966 SP_0174 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344715.1 167836 R 170187 CDS NP_344716.1 15900112 929967 complement(168025..168492) 1 NC_003028.3 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 168492 ribH 929967 ribH Streptococcus pneumoniae TIGR4 6,7-dimethyl-8-ribityllumazine synthase NP_344716.1 168025 R 170187 CDS NP_344717.1 15900113 929968 complement(168493..169698) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00926; 3,4-dihydroxy-2-butanone 4-phosphate synthase 169698 929968 SP_0176 Streptococcus pneumoniae TIGR4 3,4-dihydroxy-2-butanone 4-phosphate synthase NP_344717.1 168493 R 170187 CDS NP_344718.1 15900114 929969 complement(169718..170353) 1 NC_003028.3 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 170353 929969 SP_0177 Streptococcus pneumoniae TIGR4 riboflavin synthase subunit alpha NP_344718.1 169718 R 170187 CDS NP_344719.1 15900115 929972 complement(170338..171438) 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00326; riboflavin biosynthesis protein RibD 171438 929972 SP_0178 Streptococcus pneumoniae TIGR4 riboflavin biosynthesis protein RibD NP_344719.1 170338 R 170187 CDS NP_344720.1 15900116 929973 171843..172436 1 NC_003028.3 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 172436 ruvA 929973 ruvA Streptococcus pneumoniae TIGR4 Holliday junction DNA helicase RuvA NP_344720.1 171843 D 170187 CDS NP_344721.1 15900117 929974 172473..173009 1 NC_003028.3 DNA-3-methyladenine glycosylase I 173009 929974 SP_0180 Streptococcus pneumoniae TIGR4 DNA-3-methyladenine glycosylase I NP_344721.1 172473 D 170187 CDS NP_344722.1 15900118 929975 173006..173683 1 NC_003028.3 hypothetical protein 173683 929975 SP_0181 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344722.1 173006 D 170187 CDS NP_344723.1 15900119 929976 complement(173820..174851) 1 NC_003028.3 identified by match to PFAM protein family HMM PF02016; methylcrotonoyl-CoA carboxylase 174851 929976 SP_0182 Streptococcus pneumoniae TIGR4 methylcrotonoyl-CoA carboxylase NP_344723.1 173820 R 170187 CDS NP_344724.1 15900120 929977 complement(175039..175134) 1 NC_003028.3 hypothetical protein 175134 929977 SP_0183 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344724.1 175039 R 170187 CDS NP_344725.1 15900121 929978 complement(175106..175810) 1 NC_003028.3 hypothetical protein 175810 929978 SP_0184 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344725.1 175106 R 170187 CDS NP_344726.1 15900122 929979 complement(175801..176745) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01544; magnesium transporter CorA family protein 176745 929979 SP_0185 Streptococcus pneumoniae TIGR4 magnesium transporter CorA family protein NP_344726.1 175801 R 170187 CDS NP_344727.1 15900123 929980 176877..179708 1 NC_003028.3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 179708 uvrA 929980 uvrA Streptococcus pneumoniae TIGR4 excinuclease ABC subunit A NP_344727.1 176877 D 170187 CDS NP_344728.1 15900124 929981 179701..180762 1 NC_003028.3 identified by match to PFAM protein family HMM PF00557; peptidase M24 family protein 180762 929981 SP_0187 Streptococcus pneumoniae TIGR4 peptidase M24 family protein NP_344728.1 179701 D 170187 CDS NP_344729.1 15900125 929983 180767..180859 1 NC_003028.3 hypothetical protein 180859 929983 SP_0188 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344729.1 180767 D 170187 CDS NP_344730.1 15900126 929984 180894..181292 1 NC_003028.3 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 181292 spxA 929984 spxA Streptococcus pneumoniae TIGR4 transcriptional regulator Spx NP_344730.1 180894 D 170187 CDS NP_344731.1 15900127 929985 181261..181380 1 NC_003028.3 hypothetical protein 181380 929985 SP_0190 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344731.1 181261 D 170187 CDS NP_344732.1 15900128 929986 181358..181927 1 NC_003028.3 hypothetical protein 181927 929986 SP_0191 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344732.1 181358 D 170187 CDS NP_344733.1 15900129 929987 182014..182280 1 NC_003028.3 hypothetical protein 182280 929987 SP_0192 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344733.1 182014 D 170187 CDS NP_344734.1 15900130 929989 182719..183024 1 NC_003028.3 hypothetical protein 183024 929989 SP_0194 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344734.1 182719 D 170187 CDS NP_344735.1 15900131 929990 182990..183088 1 NC_003028.3 hypothetical protein 183088 929990 SP_0195 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344735.1 182990 D 170187 CDS NP_344736.1 15900132 929991 183073..183168 1 NC_003028.3 hypothetical protein 183168 929991 SP_0196 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344736.1 183073 D 170187 CDS NP_344737.1 15900133 929992 183283..184533 1 NC_003028.3 dihydrofolate synthetase 184533 929992 SP_0197 Streptococcus pneumoniae TIGR4 dihydrofolate synthetase NP_344737.1 183283 D 170187 CDS NP_344738.1 15900134 929993 184617..185075 1 NC_003028.3 hypothetical protein 185075 929993 SP_0198 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344738.1 184617 D 170187 CDS NP_344739.1 15900135 929994 185329..186753 1 NC_003028.3 cardiolipin synthetase 186753 929994 SP_0199 Streptococcus pneumoniae TIGR4 cardiolipin synthetase NP_344739.1 185329 D 170187 CDS NP_344740.1 15900136 929995 187011..188306 1 NC_003028.3 similar to GB:Pyro_h; identified by sequence similarity; competence-induced protein Ccs4 188306 929995 SP_0200 Streptococcus pneumoniae TIGR4 competence-induced protein Ccs4 NP_344740.1 187011 D 170187 CDS NP_344741.1 15900137 929996 188284..188550 1 NC_003028.3 hypothetical protein 188550 929996 SP_0201 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344741.1 188284 D 170187 CDS NP_344742.1 15900138 929997 188670..190877 1 NC_003028.3 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 190877 929997 SP_0202 Streptococcus pneumoniae TIGR4 anaerobic ribonucleoside triphosphate reductase NP_344742.1 188670 D 170187 CDS NP_344743.1 15900139 929999 190889..191029 1 NC_003028.3 hypothetical protein 191029 929999 SP_0203 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344743.1 190889 D 170187 CDS NP_344744.1 15900140 930000 191073..191579 1 NC_003028.3 acetyltransferase 191579 930000 SP_0204 Streptococcus pneumoniae TIGR4 acetyltransferase NP_344744.1 191073 D 170187 CDS NP_344745.1 15900141 930002 191572..192162 1 NC_003028.3 identified by match to PFAM protein family HMM PF02143; anaerobic ribonucleoside-triphosphate reductase activating protein 192162 930002 SP_0205 Streptococcus pneumoniae TIGR4 anaerobic ribonucleoside-triphosphate reductase activating protein NP_344745.1 191572 D 170187 CDS NP_344746.1 15900142 930003 192159..192461 1 NC_003028.3 hypothetical protein 192461 930003 SP_0206 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344746.1 192159 D 170187 CDS NP_344747.1 15900143 930005 192437..192775 1 NC_003028.3 similar to GP:7302796; identified by sequence similarity; hypothetical protein 192775 930005 SP_0207 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344747.1 192437 D 170187 CDS NP_344748.1 15900144 930006 193042..193350 1 NC_003028.3 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 193350 rpsJ 930006 rpsJ Streptococcus pneumoniae TIGR4 30S ribosomal protein S10 NP_344748.1 193042 D 170187 CDS NP_344749.1 15900145 930007 193567..194193 1 NC_003028.3 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 194193 rplC 930007 rplC Streptococcus pneumoniae TIGR4 50S ribosomal protein L3 NP_344749.1 193567 D 170187 CDS NP_344750.1 15900146 930009 194218..194841 1 NC_003028.3 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 194841 rplD 930009 rplD Streptococcus pneumoniae TIGR4 50S ribosomal protein L4 NP_344750.1 194218 D 170187 CDS NP_344751.1 15900147 930010 194841..195137 1 NC_003028.3 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 195137 rplW 930010 rplW Streptococcus pneumoniae TIGR4 50S ribosomal protein L23 NP_344751.1 194841 D 170187 CDS NP_344752.1 15900148 930011 195155..195988 1 NC_003028.3 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 195988 rplB 930011 rplB Streptococcus pneumoniae TIGR4 50S ribosomal protein L2 NP_344752.1 195155 D 170187 CDS NP_344753.1 15900149 930012 196092..196373 1 NC_003028.3 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 196373 rpsS 930012 rpsS Streptococcus pneumoniae TIGR4 30S ribosomal protein S19 NP_344753.1 196092 D 170187 CDS NP_344754.1 15900150 930013 196385..196729 1 NC_003028.3 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 196729 rplV 930013 rplV Streptococcus pneumoniae TIGR4 50S ribosomal protein L22 NP_344754.1 196385 D 170187 CDS NP_344755.1 15900151 930014 196742..197395 1 NC_003028.3 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 197395 rpsC 930014 rpsC Streptococcus pneumoniae TIGR4 30S ribosomal protein S3 NP_344755.1 196742 D 170187 CDS NP_344756.1 15900152 930015 197399..197812 1 NC_003028.3 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 197812 rplP 930015 rplP Streptococcus pneumoniae TIGR4 50S ribosomal protein L16 NP_344756.1 197399 D 170187 CDS NP_344757.1 15900153 930016 197822..198028 1 NC_003028.3 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 198028 rpmC 930016 rpmC Streptococcus pneumoniae TIGR4 50S ribosomal protein L29 NP_344757.1 197822 D 170187 CDS NP_344758.1 15900154 930018 198053..198313 1 NC_003028.3 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 198313 rpsQ 930018 rpsQ Streptococcus pneumoniae TIGR4 30S ribosomal protein S17 NP_344758.1 198053 D 170187 CDS NP_344759.1 15900155 930019 198339..198707 1 NC_003028.3 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 198707 rplN 930019 rplN Streptococcus pneumoniae TIGR4 50S ribosomal protein L14 NP_344759.1 198339 D 170187 CDS NP_344760.1 15900156 930020 198785..199090 1 NC_003028.3 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 199090 rplX 930020 rplX Streptococcus pneumoniae TIGR4 50S ribosomal protein L24 NP_344760.1 198785 D 170187 CDS NP_344761.1 15900157 930021 199114..199656 1 NC_003028.3 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 199656 rplE 930021 rplE Streptococcus pneumoniae TIGR4 50S ribosomal protein L5 NP_344761.1 199114 D 170187 CDS NP_344762.1 15900158 930022 199674..199943 1 NC_003028.3 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 199943 rpsN 930022 rpsN Streptococcus pneumoniae TIGR4 30S ribosomal protein S14 NP_344762.1 199674 D 170187 CDS NP_344763.1 15900159 930023 complement(199910..200032) 1 NC_003028.3 hypothetical protein 200032 930023 SP_0223 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344763.1 199910 R 170187 CDS NP_344764.1 15900160 930024 200228..200626 1 NC_003028.3 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 200626 rpsH 930024 rpsH Streptococcus pneumoniae TIGR4 30S ribosomal protein S8 NP_344764.1 200228 D 170187 CDS NP_344765.1 15900161 930025 200818..201354 1 NC_003028.3 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 201354 rplF 930025 rplF Streptococcus pneumoniae TIGR4 50S ribosomal protein L6 NP_344765.1 200818 D 170187 CDS NP_344766.1 15900162 930026 201438..201794 1 NC_003028.3 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 201794 rplR 930026 rplR Streptococcus pneumoniae TIGR4 50S ribosomal protein L18 NP_344766.1 201438 D 170187 CDS NP_344767.1 15900163 930027 201812..202306 1 NC_003028.3 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 202306 rpsE 930027 rpsE Streptococcus pneumoniae TIGR4 30S ribosomal protein S5 NP_344767.1 201812 D 170187 CDS NP_344768.1 15900164 930028 202320..202502 1 NC_003028.3 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 202502 rpmD 930028 rpmD Streptococcus pneumoniae TIGR4 50S ribosomal protein L30 NP_344768.1 202320 D 170187 CDS NP_344769.1 15900165 930029 202647..203087 1 NC_003028.3 late assembly protein; 50S ribosomal protein L15 203087 rplO 930029 rplO Streptococcus pneumoniae TIGR4 50S ribosomal protein L15 NP_344769.1 202647 D 170187 CDS NP_344770.1 15900166 930030 203100..204410 1 NC_003028.3 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 204410 secY 930030 secY Streptococcus pneumoniae TIGR4 preprotein translocase subunit SecY NP_344770.1 203100 D 170187 CDS NP_344771.1 15900167 930031 204561..205199 1 NC_003028.3 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 205199 adk 930031 adk Streptococcus pneumoniae TIGR4 adenylate kinase NP_344771.1 204561 D 170187 CDS NP_344772.1 15900168 930032 205316..205534 1 NC_003028.3 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 205534 infA 930032 infA Streptococcus pneumoniae TIGR4 translation initiation factor IF-1 NP_344772.1 205316 D 170187 CDS NP_344773.1 15900169 930033 205559..205675 1 NC_003028.3 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 205675 rpmJ 930033 rpmJ Streptococcus pneumoniae TIGR4 50S ribosomal protein L36 NP_344773.1 205559 D 170187 CDS NP_344774.1 15900170 930034 205693..206058 1 NC_003028.3 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 206058 rpsM 930034 rpsM Streptococcus pneumoniae TIGR4 30S ribosomal protein S13 NP_344774.1 205693 D 170187 CDS NP_344775.1 15900171 930035 206076..206459 1 NC_003028.3 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 206459 930035 SP_0235 Streptococcus pneumoniae TIGR4 30S ribosomal protein S11 NP_344775.1 206076 D 170187 CDS NP_344776.1 15900172 930036 206502..207437 1 NC_003028.3 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 207437 930036 SP_0236 Streptococcus pneumoniae TIGR4 DNA-directed RNA polymerase subunit alpha NP_344776.1 206502 D 170187 CDS NP_344777.1 15900173 930037 207449..207835 1 NC_003028.3 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 207835 rplQ 930037 rplQ Streptococcus pneumoniae TIGR4 50S ribosomal protein L17 NP_344777.1 207449 D 170187 CDS NP_344778.1 15900174 930038 208100..208366 1 NC_003028.3 ACT domain-containing protein; hypothetical protein 208366 930038 SP_0238 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344778.1 208100 D 170187 CDS NP_344779.1 15900175 930039 208376..209713 1 NC_003028.3 hypothetical protein 209713 930039 SP_0239 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344779.1 208376 D 170187 CDS NP_344780.1 15900176 930040 209957..210649 1 NC_003028.3 phosphoglycerate mutase 210649 930040 SP_0240 Streptococcus pneumoniae TIGR4 phosphoglycerate mutase NP_344780.1 209957 D 170187 CDS NP_344781.1 15900177 930043 complement(212387..213478) 1 NC_003028.3 ABC transporter ATP-binding protein 213478 930043 SP_0242 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_344781.1 212387 R 170187 CDS NP_344782.1 15900178 930044 complement(213491..214507) 1 NC_003028.3 iron ABC transporter substrate-binding protein 214507 930044 SP_0243 Streptococcus pneumoniae TIGR4 iron ABC transporter substrate-binding protein NP_344782.1 213491 R 170187 CDS NP_344783.1 15900179 930045 complement(214812..214919) 1 NC_003028.3 hypothetical protein 214919 930045 SP_0244 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344783.1 214812 R 170187 CDS NP_344784.1 15900180 930046 complement(215094..215870) 1 NC_003028.3 identified by match to PFAM protein family HMM PF02143; pyruvate formate-lyase-activating enzyme 215870 930046 SP_0245 Streptococcus pneumoniae TIGR4 pyruvate formate-lyase-activating enzyme NP_344784.1 215094 R 170187 CDS NP_344785.1 15900181 930048 215992..216738 1 NC_003028.3 DeoR family transcriptional regulator 216738 930048 SP_0246 Streptococcus pneumoniae TIGR4 DeoR family transcriptional regulator NP_344785.1 215992 D 170187 CDS NP_344786.1 15900182 930049 216751..217731 1 NC_003028.3 similar to SP:P37078 GB:X66059 PID:43938; identified by sequence similarity; transcriptional regulator 217731 930049 SP_0247 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_344786.1 216751 D 170187 CDS NP_344787.1 15900183 930050 217926..218246 1 NC_003028.3 PTS system transporter subunit IIA 218246 930050 SP_0248 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIA NP_344787.1 217926 D 170187 CDS NP_344788.1 15900184 930051 218292..218600 1 NC_003028.3 PTS system transporter subunit IIB 218600 930051 SP_0249 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIB NP_344788.1 218292 D 170187 CDS NP_344789.1 15900185 930052 218593..219915 1 NC_003028.3 PTS system transporter subunit IIC 219915 930052 SP_0250 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIC NP_344789.1 218593 D 170187 CDS NP_344790.1 15900186 930053 220066..222504 1 NC_003028.3 identified by match to PFAM protein family HMM PF01228; formate acetyltransferase 222504 930053 SP_0251 Streptococcus pneumoniae TIGR4 formate acetyltransferase NP_344790.1 220066 D 170187 CDS NP_344791.1 15900187 930054 222523..223191 1 NC_003028.3 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 223191 930054 SP_0252 Streptococcus pneumoniae TIGR4 fructose-6-phosphate aldolase NP_344791.1 222523 D 170187 CDS NP_344792.1 15900188 930055 223209..224297 1 NC_003028.3 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 224297 gldA 930055 gldA Streptococcus pneumoniae TIGR4 glycerol dehydrogenase NP_344792.1 223209 D 170187 CDS NP_344793.1 15900189 930056 224752..227253 1 NC_003028.3 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 227253 leuS 930056 leuS Streptococcus pneumoniae TIGR4 leucyl-tRNA synthetase NP_344793.1 224752 D 170187 CDS NP_344794.1 15900190 930057 227448..228143 1 NC_003028.3 acetyltransferase 228143 930057 SP_0255 Streptococcus pneumoniae TIGR4 acetyltransferase NP_344794.1 227448 D 170187 CDS NP_344795.1 15900191 930059 228155..228571 1 NC_003028.3 acetyltransferase 228571 930059 SP_0256 Streptococcus pneumoniae TIGR4 acetyltransferase NP_344795.1 228155 D 170187 CDS NP_344796.1 15900192 930061 complement(231373..231465) 1 NC_003028.3 hypothetical protein 231465 930061 SP_0258 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344796.1 231373 R 170187 CDS NP_344797.1 15900193 930063 231600..232598 1 NC_003028.3 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 232598 ruvB 930063 ruvB Streptococcus pneumoniae TIGR4 Holliday junction DNA helicase RuvB NP_344797.1 231600 D 170187 CDS NP_344798.1 15900194 930064 232579..233151 1 NC_003028.3 hypothetical protein 233151 930064 SP_0260 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344798.1 232579 D 170187 CDS NP_344799.1 15900195 930065 233382..234140 1 NC_003028.3 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 234140 930065 SP_0261 Streptococcus pneumoniae TIGR4 undecaprenyl pyrophosphate synthase NP_344799.1 233382 D 170187 CDS NP_344800.1 15900196 930067 234149..234952 1 NC_003028.3 phosphatidate cytidylyltransferase 234952 930067 SP_0262 Streptococcus pneumoniae TIGR4 phosphatidate cytidylyltransferase NP_344800.1 234149 D 170187 CDS NP_344801.1 15900197 930069 234974..236233 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00054; eep protein 236233 930069 SP_0263 Streptococcus pneumoniae TIGR4 eep protein NP_344801.1 234974 D 170187 CDS NP_344802.1 15900198 930070 236246..238099 1 NC_003028.3 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 238099 930070 SP_0264 Streptococcus pneumoniae TIGR4 prolyl-tRNA synthetase NP_344802.1 236246 D 170187 CDS NP_344803.1 15900199 930071 238198..239577 1 NC_003028.3 glycosyl hydrolase 239577 930071 SP_0265 Streptococcus pneumoniae TIGR4 glycosyl hydrolase NP_344803.1 238198 D 170187 CDS NP_344804.1 15900200 930072 239770..241578 1 NC_003028.3 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 241578 930072 SP_0266 Streptococcus pneumoniae TIGR4 glucosamine--fructose-6-phosphate aminotransferase NP_344804.1 239770 D 170187 CDS NP_344805.1 15900201 930074 241697..242746 1 NC_003028.3 similar to GP:2735505; identified by sequence similarity; hypothetical protein 242746 930074 SP_0267 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344805.1 241697 D 170187 CDS NP_344806.1 15900202 930075 complement(242846..246688) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00746; alkaline amylopullulanase 246688 930075 SP_0268 Streptococcus pneumoniae TIGR4 alkaline amylopullulanase NP_344806.1 242846 R 170187 CDS NP_344807.1 15900203 930076 246875..246970 1 NC_003028.3 hypothetical protein 246970 930076 SP_0269 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344807.1 246875 D 170187 CDS NP_344808.1 15900204 930078 247026..247118 1 NC_003028.3 hypothetical protein 247118 930078 SP_0270 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344808.1 247026 D 170187 CDS NP_344809.1 15900205 930079 247105..247518 1 NC_003028.3 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 247518 rpsL 930079 rpsL Streptococcus pneumoniae TIGR4 30S ribosomal protein S12 NP_344809.1 247105 D 170187 CDS NP_344810.1 15900206 930080 247538..248008 1 NC_003028.3 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 248008 930080 SP_0272 Streptococcus pneumoniae TIGR4 30S ribosomal protein S7 NP_344810.1 247538 D 170187 CDS NP_344811.1 15900207 930081 248433..250514 1 NC_003028.3 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 250514 930081 SP_0273 Streptococcus pneumoniae TIGR4 elongation factor G NP_344811.1 248433 D 170187 CDS NP_344812.1 15900208 930082 250618..255009 1 NC_003028.3 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 255009 polC 930082 polC Streptococcus pneumoniae TIGR4 DNA polymerase III PolC NP_344812.1 250618 D 170187 CDS NP_344813.1 15900209 930083 255111..255374 1 NC_003028.3 hypothetical protein 255374 930083 SP_0275 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344813.1 255111 D 170187 CDS NP_344814.1 15900210 930084 255367..255645 1 NC_003028.3 hypothetical protein 255645 930084 SP_0276 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344814.1 255367 D 170187 CDS NP_344815.1 15900211 930086 255666..255818 1 NC_003028.3 hypothetical protein 255818 930086 SP_0277 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344815.1 255666 D 170187 CDS NP_344816.1 15900212 930087 255840..257081 1 NC_003028.3 identified by match to PFAM protein family HMM PF02073; aminopeptidase 257081 930087 SP_0278 Streptococcus pneumoniae TIGR4 aminopeptidase NP_344816.1 255840 D 170187 CDS NP_344817.1 15900213 930088 257091..257321 1 NC_003028.3 hypothetical protein 257321 930088 SP_0279 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344817.1 257091 D 170187 CDS NP_344818.1 15900214 930089 257589..258311 1 NC_003028.3 ribosomal small subunit pseudouridine synthase A 258311 930089 SP_0280 Streptococcus pneumoniae TIGR4 ribosomal small subunit pseudouridine synthase A NP_344818.1 257589 D 170187 CDS NP_344819.1 15900215 930090 258529..259863 1 NC_003028.3 similar to GB:Z30315 PID:535273; identified by sequence similarity; aminopeptidase 259863 930090 SP_0281 Streptococcus pneumoniae TIGR4 aminopeptidase NP_344819.1 258529 D 170187 CDS NP_344820.1 15900216 930091 complement(259919..260830) 1 NC_003028.3 PTS system mannose-specific transporter subunit IID 260830 930091 SP_0282 Streptococcus pneumoniae TIGR4 PTS system mannose-specific transporter subunit IID NP_344820.1 259919 R 170187 CDS NP_344821.1 15900217 930092 complement(260854..261657) 1 NC_003028.3 PTS system mannose-specific transporter subunit IIC 261657 930092 SP_0283 Streptococcus pneumoniae TIGR4 PTS system mannose-specific transporter subunit IIC NP_344821.1 260854 R 170187 CDS NP_344822.1 15900218 930093 complement(261685..262683) 1 NC_003028.3 PTS system mannose-specific transporter subunit IIAB 262683 930093 SP_0284 Streptococcus pneumoniae TIGR4 PTS system mannose-specific transporter subunit IIAB NP_344822.1 261685 R 170187 CDS NP_344823.1 15900219 930095 complement(262907..263926) 1 NC_003028.3 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 263926 930095 SP_0285 Streptococcus pneumoniae TIGR4 alcohol dehydrogenase NP_344823.1 262907 R 170187 CDS NP_344824.1 15900220 930097 complement(264266..265078) 1 NC_003028.3 Cof family protein 265078 930097 SP_0286 Streptococcus pneumoniae TIGR4 Cof family protein NP_344824.1 264266 R 170187 CDS NP_344825.1 15900221 930098 265214..266686 1 NC_003028.3 xanthine/uracil permease 266686 930098 SP_0287 Streptococcus pneumoniae TIGR4 xanthine/uracil permease NP_344825.1 265214 D 170187 CDS NP_344826.1 15900222 930099 266754..267446 1 NC_003028.3 hypothetical protein 267446 930099 SP_0288 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344826.1 266754 D 170187 CDS NP_344827.1 15900223 930100 267571..268515 1 NC_003028.3 identified by match to PFAM protein family HMM PF00809; dihydropteroate synthase 268515 930100 SP_0289 Streptococcus pneumoniae TIGR4 dihydropteroate synthase NP_344827.1 267571 D 170187 CDS NP_344828.1 15900224 930101 268517..269839 1 NC_003028.3 dihydrofolate synthetase 269839 930101 SP_0290 Streptococcus pneumoniae TIGR4 dihydrofolate synthetase NP_344828.1 268517 D 170187 CDS NP_344829.1 15900225 930102 269820..270374 1 NC_003028.3 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 270374 folE 930102 folE Streptococcus pneumoniae TIGR4 GTP cyclohydrolase I NP_344829.1 269820 D 170187 CDS NP_344830.1 15900226 930103 270417..271229 1 NC_003028.3 identified by match to PFAM protein family HMM PF01288; bifunctional folate synthesis protein 271229 930103 SP_0292 Streptococcus pneumoniae TIGR4 bifunctional folate synthesis protein NP_344830.1 270417 D 170187 CDS NP_344831.1 15900227 930105 complement(271379..271750) 1 NC_003028.3 hypothetical protein 271750 930105 SP_0293 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344831.1 271379 R 170187 CDS NP_344832.1 15900228 930106 272052..272498 1 NC_003028.3 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 272498 rplM 930106 rplM Streptococcus pneumoniae TIGR4 50S ribosomal protein L13 NP_344832.1 272052 D 170187 CDS NP_344833.1 15900229 930107 272517..272909 1 NC_003028.3 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 272909 rpsI 930107 rpsI Streptococcus pneumoniae TIGR4 30S ribosomal protein S9 NP_344833.1 272517 D 170187 CDS NP_344834.1 15900230 930108 complement(273172..273303) 1 NC_003028.3 hypothetical protein 273303 930108 SP_0296 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344834.1 273172 R 170187 CDS NP_344835.1 15900231 930109 complement(273502..273651) 1 NC_003028.3 hypothetical protein 273651 930109 SP_0297 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344835.1 273502 R 170187 CDS NP_344836.1 15900232 930110 complement(273953..275161) 1 NC_003028.3 hypothetical protein 275161 930110 SP_0298 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344836.1 273953 R 170187 CDS NP_344837.1 15900233 930111 275290..275637 1 NC_003028.3 IS630-Spn1, transposase Orf1, authentic frameshift 275637 930111 SP_0299 Streptococcus pneumoniae TIGR4 IS630-Spn1, transposase Orf1, authentic frameshift NP_344837.1 275290 D 170187 CDS NP_344838.1 15900234 930112 275816..276154 1 NC_003028.3 IS630-Spn1, transposase Orf2 276154 930112 SP_0300 Streptococcus pneumoniae TIGR4 IS630-Spn1, transposase Orf2 NP_344838.1 275816 D 170187 CDS NP_344839.1 15900235 930115 276283..276648 1 NC_003028.3 similar to GP:9658050; identified by sequence similarity; hypothetical protein 276648 930115 SP_0302 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344839.1 276283 D 170187 CDS NP_344840.1 15900236 930116 276838..278274 1 NC_003028.3 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 278274 celA 930116 celA Streptococcus pneumoniae TIGR4 6-phospho-beta-glucosidase NP_344840.1 276838 D 170187 CDS NP_344841.1 15900237 930117 278326..278565 1 NC_003028.3 hypothetical protein 278565 930117 SP_0304 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344841.1 278326 D 170187 CDS NP_344842.1 15900238 930118 278695..279009 1 NC_003028.3 required for cellobiose uptake and metabolism; PTS system cellobiose transporter subunit IIB 279009 celB 930118 celB Streptococcus pneumoniae TIGR4 PTS system cellobiose transporter subunit IIB NP_344842.1 278695 D 170187 CDS NP_344843.1 15900239 930119 279127..280608 1 NC_003028.3 transcriptional regulator 280608 930119 SP_0306 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_344843.1 279127 D 170187 CDS NP_344844.1 15900240 930120 280609..281106 1 NC_003028.3 PTS system transporter subunit IIA 281106 930120 SP_0307 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIA NP_344844.1 280609 D 170187 CDS NP_344845.1 15900241 930121 281116..281430 1 NC_003028.3 required for cellobiose uptake and metabolism; cellobiose phosphotransferase system IIA component 281430 celC 930121 celC Streptococcus pneumoniae TIGR4 cellobiose phosphotransferase system IIA component NP_344845.1 281116 D 170187 CDS NP_344846.1 15900242 930122 281461..281967 1 NC_003028.3 hypothetical protein 281967 930122 SP_0309 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344846.1 281461 D 170187 CDS NP_344847.1 15900243 930123 282047..283393 1 NC_003028.3 required for cellobiose uptake and metabolism; cellobiose phosphotransferase system IIC component 283393 celD 930123 celD Streptococcus pneumoniae TIGR4 cellobiose phosphotransferase system IIC component NP_344847.1 282047 D 170187 CDS NP_344848.1 15900244 930124 283772..283948 1 NC_003028.3 hypothetical protein 283948 930124 SP_0311 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344848.1 283772 D 170187 CDS NP_344849.1 15900245 930125 284523..286562 1 NC_003028.3 identified by match to PFAM protein family HMM PF01055; glycosyl hydrolase 286562 930125 SP_0312 Streptococcus pneumoniae TIGR4 glycosyl hydrolase NP_344849.1 284523 D 170187 CDS NP_344850.1 15900246 930126 complement(286784..287260) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00255; glutathione peroxidase 287260 930126 SP_0313 Streptococcus pneumoniae TIGR4 glutathione peroxidase NP_344850.1 286784 R 170187 CDS NP_344851.1 15900247 930127 287483..290683 1 NC_003028.3 identified by match to PFAM protein family HMM PF02278; hyaluronidase 290683 930127 SP_0314 Streptococcus pneumoniae TIGR4 hyaluronidase NP_344851.1 287483 D 170187 CDS NP_344852.1 15900248 930129 complement(291700..291807) 1 NC_003028.3 hypothetical protein 291807 930129 SP_0316 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344852.1 291700 R 170187 CDS NP_344853.1 15900249 930130 complement(291831..292460) 1 NC_003028.3 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 292460 930130 SP_0317 Streptococcus pneumoniae TIGR4 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase NP_344853.1 291831 R 170187 CDS NP_344854.1 15900250 930131 complement(292470..293471) 1 NC_003028.3 carbohydrate kinase 293471 930131 SP_0318 Streptococcus pneumoniae TIGR4 carbohydrate kinase NP_344854.1 292470 R 170187 CDS NP_344855.1 15900251 930132 complement(293502..294143) 1 NC_003028.3 hypothetical protein 294143 930132 SP_0319 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344855.1 293502 R 170187 CDS NP_344856.1 15900252 930133 complement(294162..294977) 1 NC_003028.3 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 294977 930133 SP_0320 Streptococcus pneumoniae TIGR4 gluconate 5-dehydrogenase NP_344856.1 294162 R 170187 CDS NP_344857.1 15900253 930134 295248..295682 1 NC_003028.3 PTS system transporter subunit IIA 295682 930134 SP_0321 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIA NP_344857.1 295248 D 170187 CDS NP_344858.1 15900254 930136 295694..296884 1 NC_003028.3 similar to GP:5869507; identified by sequence similarity; glucuronyl hydrolase 296884 930136 SP_0322 Streptococcus pneumoniae TIGR4 glucuronyl hydrolase NP_344858.1 295694 D 170187 CDS NP_344859.1 15900255 930137 296895..297386 1 NC_003028.3 PTS system transporter subunit IIB 297386 930137 SP_0323 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIB NP_344859.1 296895 D 170187 CDS NP_344860.1 15900256 930138 297401..298180 1 NC_003028.3 PTS system transporter subunit IIC 298180 930138 SP_0324 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIC NP_344860.1 297401 D 170187 CDS NP_344861.1 15900257 930139 298167..298985 1 NC_003028.3 PTS system transporter subunit IID 298985 930139 SP_0325 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IID NP_344861.1 298167 D 170187 CDS NP_344862.1 15900258 930141 298985..299278 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00739; preprotein translocase subunit YajC 299278 930141 SP_0326 Streptococcus pneumoniae TIGR4 preprotein translocase subunit YajC NP_344862.1 298985 D 170187 CDS NP_344863.1 15900259 930142 299300..300940 1 NC_003028.3 hypothetical protein 300940 930142 SP_0327 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344863.1 299300 D 170187 CDS NP_344864.1 15900260 930143 301056..302402 1 NC_003028.3 similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 302402 930143 SP_0328 Streptococcus pneumoniae TIGR4 IS1380-Spn1 transposase NP_344864.1 301056 D 170187 CDS NP_344865.1 15900261 930144 302580..302909 1 NC_003028.3 hypothetical protein 302909 930144 SP_0329 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344865.1 302580 D 170187 CDS NP_344866.1 15900262 930145 302969..303970 1 NC_003028.3 sugar binding transcriptional regulator RegR 303970 930145 SP_0330 Streptococcus pneumoniae TIGR4 sugar binding transcriptional regulator RegR NP_344866.1 302969 D 170187 CDS NP_344867.1 15900263 930147 complement(304679..305221) 1 NC_003028.3 hypothetical protein 305221 930147 SP_0332 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344867.1 304679 R 170187 CDS NP_344868.1 15900264 930150 complement(305237..305431) 1 NC_003028.3 transcriptional regulator 305431 930150 SP_0333 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_344868.1 305237 R 170187 CDS NP_344869.1 15900265 930151 305597..306547 1 NC_003028.3 S-adenosyl-methyltransferase MraW 306547 mraW 930151 mraW Streptococcus pneumoniae TIGR4 S-adenosyl-methyltransferase MraW NP_344869.1 305597 D 170187 CDS NP_344870.1 15900266 930152 306559..306876 1 NC_003028.3 similar to GP:1524351; identified by sequence similarity; cell division protein FtsL 306876 930152 SP_0335 Streptococcus pneumoniae TIGR4 cell division protein FtsL NP_344870.1 306559 D 170187 CDS NP_344871.1 15900267 930153 306880..309132 1 NC_003028.3 penicillin-binding protein 2X 309132 930153 SP_0336 Streptococcus pneumoniae TIGR4 penicillin-binding protein 2X NP_344871.1 306880 D 170187 CDS NP_344872.1 15900268 930154 309134..310114 1 NC_003028.3 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 310114 mraY 930154 mraY Streptococcus pneumoniae TIGR4 phospho-N-acetylmuramoyl-pentapeptide- transferase NP_344872.1 309134 D 170187 CDS NP_344873.1 15900269 930156 310723..312828 1 NC_003028.3 ATP-dependent Clp protease ATP-binding subunit 312828 930156 SP_0338 Streptococcus pneumoniae TIGR4 ATP-dependent Clp protease ATP-binding subunit NP_344873.1 310723 D 170187 CDS NP_344874.1 15900270 930158 complement(313124..313606) 1 NC_003028.3 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 313606 930158 SP_0340 Streptococcus pneumoniae TIGR4 S-ribosylhomocysteinase NP_344874.1 313124 R 170187 CDS NP_344875.1 15900271 930159 complement(313701..315185) 1 NC_003028.3 hypothetical protein 315185 930159 SP_0341 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344875.1 313701 R 170187 CDS NP_344876.1 15900272 930160 315338..316945 1 NC_003028.3 glucan 1,6-alpha-glucosidase 316945 930160 SP_0342 Streptococcus pneumoniae TIGR4 glucan 1,6-alpha-glucosidase NP_344876.1 315338 D 170187 CDS NP_344877.1 15900273 930161 complement(317355..318701) 1 NC_003028.3 similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 318701 930161 SP_0343 Streptococcus pneumoniae TIGR4 IS1380-Spn1 transposase NP_344877.1 317355 R 170187 CDS NP_344878.1 15900274 930162 complement(318978..319316) 1 NC_003028.3 IS630-Spn1, transposase Orf2 319316 930162 SP_0344 Streptococcus pneumoniae TIGR4 IS630-Spn1, transposase Orf2 NP_344878.1 318978 R 170187 CDS YP_873925.1 118090039 930163 complement(319495..319842) 1 NC_003028.3 Orf1; IS630-Spn1 transposase 319842 930163 SP_0345 Streptococcus pneumoniae TIGR4 IS630-Spn1 transposase YP_873925.1 319495 R 170187 CDS NP_344879.1 15900275 930165 320077..321522 1 NC_003028.3 capsular polysaccharide biosynthesis protein Cps4A 321522 930165 SP_0346 Streptococcus pneumoniae TIGR4 capsular polysaccharide biosynthesis protein Cps4A NP_344879.1 320077 D 170187 CDS NP_344880.1 15900276 930166 321524..322255 1 NC_003028.3 similar to GP:3550628; identified by sequence similarity; capsular polysaccharide biosynthesis protein Cps4B 322255 930166 SP_0347 Streptococcus pneumoniae TIGR4 capsular polysaccharide biosynthesis protein Cps4B NP_344880.1 321524 D 170187 CDS NP_344881.1 15900277 930167 322264..322956 1 NC_003028.3 capsular polysaccharide biosynthesis protein Cps4C 322956 930167 SP_0348 Streptococcus pneumoniae TIGR4 capsular polysaccharide biosynthesis protein Cps4C NP_344881.1 322264 D 170187 CDS NP_344882.1 15900278 930168 322966..323649 1 NC_003028.3 capsular polysaccharide biosynthesis protein Cps4D 323649 930168 SP_0349 Streptococcus pneumoniae TIGR4 capsular polysaccharide biosynthesis protein Cps4D NP_344882.1 322966 D 170187 CDS NP_344883.1 15900279 930169 323990..324625 1 NC_003028.3 identified by match to PFAM protein family HMM PF02397; capsular polysaccharide biosynthesis protein Cps4E 324625 930169 SP_0350 Streptococcus pneumoniae TIGR4 capsular polysaccharide biosynthesis protein Cps4E NP_344883.1 323990 D 170187 CDS NP_344884.1 15900280 930170 324634..325863 1 NC_003028.3 capsular polysaccharide biosynthesis protein Cps4F 325863 930170 SP_0351 Streptococcus pneumoniae TIGR4 capsular polysaccharide biosynthesis protein Cps4F NP_344884.1 324634 D 170187 CDS NP_344885.1 15900281 930171 325868..326944 1 NC_003028.3 similar to GP:1657647; identified by sequence similarity; capsular polysaccharide biosynthesis protein Cps4G 326944 930171 SP_0352 Streptococcus pneumoniae TIGR4 capsular polysaccharide biosynthesis protein Cps4G NP_344885.1 325868 D 170187 CDS NP_344886.1 15900282 930172 326937..328055 1 NC_003028.3 capsular polysaccharide biosynthesis protein Cps4H 328055 930172 SP_0353 Streptococcus pneumoniae TIGR4 capsular polysaccharide biosynthesis protein Cps4H NP_344886.1 326937 D 170187 CDS NP_344887.1 15900283 930173 328056..329456 1 NC_003028.3 hypothetical protein 329456 930173 SP_0354 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344887.1 328056 D 170187 CDS NP_344888.1 15900284 930174 329456..330538 1 NC_003028.3 hypothetical protein 330538 930174 SP_0355 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344888.1 329456 D 170187 CDS NP_344889.1 15900285 930175 330528..331769 1 NC_003028.3 polysaccharide transporter 331769 930175 SP_0356 Streptococcus pneumoniae TIGR4 polysaccharide transporter NP_344889.1 330528 D 170187 CDS NP_344890.1 15900286 930176 331774..332871 1 NC_003028.3 identified by match to PFAM protein family HMM PF02350; UDP-N-acetylglucosamine-2-epimerase 332871 930176 SP_0357 Streptococcus pneumoniae TIGR4 UDP-N-acetylglucosamine-2-epimerase NP_344890.1 331774 D 170187 CDS NP_344891.1 15900287 930177 332875..333930 1 NC_003028.3 capsular polysaccharide biosynthesis protein Cps4J 333930 930177 SP_0358 Streptococcus pneumoniae TIGR4 capsular polysaccharide biosynthesis protein Cps4J NP_344891.1 332875 D 170187 CDS NP_344892.1 15900288 930178 334030..335259 1 NC_003028.3 capsular polysaccharide biosynthesis protein Cps4K 335259 930178 SP_0359 Streptococcus pneumoniae TIGR4 capsular polysaccharide biosynthesis protein Cps4K NP_344892.1 334030 D 170187 CDS NP_344893.1 15900289 930186 335260..336444 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00236; UDP-N-acetylglucosamine 2-epimerase 336444 930186 SP_0360 Streptococcus pneumoniae TIGR4 UDP-N-acetylglucosamine 2-epimerase NP_344893.1 335260 D 170187 CDS NP_344894.1 15900290 930256 339096..341081 1 NC_003028.3 oligopeptide ABC transporter oligopeptide-binding protein AliA 341081 930256 SP_0366 Streptococcus pneumoniae TIGR4 oligopeptide ABC transporter oligopeptide-binding protein AliA NP_344894.1 339096 D 170187 CDS NP_344895.1 15900291 930260 341229..341348 1 NC_003028.3 hypothetical protein 341348 930260 SP_0367 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344895.1 341229 D 170187 CDS YP_873926.1 118090040 930268 341383..346686 1 NC_003028.3 cell wall surface anchor family protein 346686 930268 SP_0368 Streptococcus pneumoniae TIGR4 cell wall surface anchor family protein YP_873926.1 341383 D 170187 CDS NP_344896.1 15900292 930269 complement(346853..349012) 1 NC_003028.3 penicillin-binding protein 1A 349012 930269 SP_0369 Streptococcus pneumoniae TIGR4 penicillin-binding protein 1A NP_344896.1 346853 R 170187 CDS NP_344897.1 15900293 930277 complement(349009..349605) 1 NC_003028.3 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease 349605 recU 930277 recU Streptococcus pneumoniae TIGR4 Holliday junction-specific endonuclease NP_344897.1 349009 R 170187 CDS NP_344898.1 15900294 930279 349671..350198 1 NC_003028.3 hypothetical protein 350198 930279 SP_0371 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344898.1 349671 D 170187 CDS NP_344899.1 15900295 930282 350268..350597 1 NC_003028.3 hypothetical protein 350597 930282 SP_0372 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344899.1 350268 D 170187 CDS NP_344900.1 15900296 930284 351083..352240 1 NC_003028.3 hypothetical protein 352240 930284 SP_0373 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344900.1 351083 D 170187 CDS NP_344901.1 15900297 930285 352253..353647 1 NC_003028.3 hypothetical protein 353647 930285 SP_0374 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344901.1 352253 D 170187 CDS NP_344902.1 15900298 930286 353723..355147 1 NC_003028.3 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 355147 930286 SP_0375 Streptococcus pneumoniae TIGR4 6-phosphogluconate dehydrogenase NP_344902.1 353723 D 170187 CDS NP_344903.1 15900299 930289 355159..355848 1 NC_003028.3 DNA-binding response regulator 355848 930289 SP_0376 Streptococcus pneumoniae TIGR4 DNA-binding response regulator NP_344903.1 355159 D 170187 CDS NP_344904.1 15900300 930291 355947..356969 1 NC_003028.3 choline binding protein C 356969 930291 SP_0377 Streptococcus pneumoniae TIGR4 choline binding protein C NP_344904.1 355947 D 170187 CDS NP_344905.1 15900301 930292 356987..357985 1 NC_003028.3 choline binding protein J 357985 930292 SP_0378 Streptococcus pneumoniae TIGR4 choline binding protein J NP_344905.1 356987 D 170187 CDS NP_344906.1 15900302 930294 complement(358103..359335) 1 NC_003028.3 hypothetical protein 359335 930294 SP_0379 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344906.1 358103 R 170187 CDS NP_344907.1 15900303 930295 complement(359378..360253) 1 NC_003028.3 hypothetical protein 360253 930295 SP_0380 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344907.1 359378 R 170187 CDS NP_344908.1 15900304 930296 361318..362196 1 NC_003028.3 mevalonate kinase 362196 930296 SP_0381 Streptococcus pneumoniae TIGR4 mevalonate kinase NP_344908.1 361318 D 170187 CDS NP_344909.1 15900305 930298 362178..363131 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR01240; diphosphomevalonate decarboxylase 363131 930298 SP_0382 Streptococcus pneumoniae TIGR4 diphosphomevalonate decarboxylase NP_344909.1 362178 D 170187 CDS NP_344910.1 15900306 930299 363118..364125 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR01220; phosphomevalonate kinase 364125 930299 SP_0383 Streptococcus pneumoniae TIGR4 phosphomevalonate kinase NP_344910.1 363118 D 170187 CDS NP_344911.1 15900307 930300 364109..365119 1 NC_003028.3 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 365119 930300 SP_0384 Streptococcus pneumoniae TIGR4 isopentenyl pyrophosphate isomerase NP_344911.1 364109 D 170187 CDS NP_344912.1 15900308 930301 365196..365894 1 NC_003028.3 hypothetical protein 365894 930301 SP_0385 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344912.1 365196 D 170187 CDS NP_344913.1 15900309 930303 365891..366886 1 NC_003028.3 sensor histidine kinase 366886 930303 SP_0386 Streptococcus pneumoniae TIGR4 sensor histidine kinase NP_344913.1 365891 D 170187 CDS NP_344914.1 15900310 930305 366900..367532 1 NC_003028.3 DNA-binding response regulator 367532 930305 SP_0387 Streptococcus pneumoniae TIGR4 DNA-binding response regulator NP_344914.1 366900 D 170187 CDS NP_344915.1 15900311 930308 368451..368690 1 NC_003028.3 hypothetical protein 368690 930308 SP_0389 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344915.1 368451 D 170187 CDS NP_344916.1 15900312 930309 368735..369592 1 NC_003028.3 choline binding protein G 369592 930309 SP_0390 Streptococcus pneumoniae TIGR4 choline binding protein G NP_344916.1 368735 D 170187 CDS NP_344917.1 15900313 930315 369611..370633 1 NC_003028.3 choline binding protein F 370633 930315 SP_0391 Streptococcus pneumoniae TIGR4 choline binding protein F NP_344917.1 369611 D 170187 CDS NP_344918.1 15900314 930325 372310..374079 1 NC_003028.3 PTS system mannitol-specific transporter subunit IIBC 374079 930325 SP_0394 Streptococcus pneumoniae TIGR4 PTS system mannitol-specific transporter subunit IIBC NP_344918.1 372310 D 170187 CDS NP_344919.1 15900315 930326 374103..376058 1 NC_003028.3 transcriptional regulator 376058 930326 SP_0395 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_344919.1 374103 D 170187 CDS NP_344920.1 15900316 930330 376060..376497 1 NC_003028.3 PTS system mannitol-specific transporter subunit IIA 376497 930330 SP_0396 Streptococcus pneumoniae TIGR4 PTS system mannitol-specific transporter subunit IIA NP_344920.1 376060 D 170187 CDS NP_344921.1 15900317 930331 376559..377695 1 NC_003028.3 identified by match to PFAM protein family HMM PF01232; mannitol-1-phosphate 5-dehydrogenase 377695 930331 SP_0397 Streptococcus pneumoniae TIGR4 mannitol-1-phosphate 5-dehydrogenase NP_344921.1 376559 D 170187 CDS NP_344922.1 15900318 930332 377853..378011 1 NC_003028.3 hypothetical protein 378011 930332 SP_0398 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344922.1 377853 D 170187 CDS NP_344923.1 15900319 930334 378481..379764 1 NC_003028.3 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 379764 tig 930334 tig Streptococcus pneumoniae TIGR4 trigger factor NP_344923.1 378481 D 170187 CDS NP_344924.1 15900320 930335 complement(379812..382178) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01443; helicase 382178 930335 SP_0401 Streptococcus pneumoniae TIGR4 helicase NP_344924.1 379812 R 170187 CDS NP_344925.1 15900321 930336 complement(382457..383071) 1 NC_003028.3 signal peptidase I 383071 930336 SP_0402 Streptococcus pneumoniae TIGR4 signal peptidase I NP_344925.1 382457 R 170187 CDS NP_344926.1 15900322 930337 complement(383075..383956) 1 NC_003028.3 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII 383956 930337 SP_0403 Streptococcus pneumoniae TIGR4 ribonuclease HIII NP_344926.1 383075 R 170187 CDS NP_344927.1 15900323 930340 384034..384345 1 NC_003028.3 hypothetical protein 384345 930340 SP_0404 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344927.1 384034 D 170187 CDS NP_344928.1 15900324 930341 384342..384890 1 NC_003028.3 hypothetical protein 384890 930341 SP_0405 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344928.1 384342 D 170187 CDS NP_344929.1 15900325 930342 384994..387330 1 NC_003028.3 MutS2 family protein 387330 930342 SP_0406 Streptococcus pneumoniae TIGR4 MutS2 family protein NP_344929.1 384994 D 170187 CDS NP_344930.1 15900326 930343 complement(387451..387552) 1 NC_003028.3 hypothetical protein 387552 930343 SP_0407 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344930.1 387451 R 170187 CDS NP_344931.1 15900327 930344 387673..388995 1 NC_003028.3 identified by match to PFAM protein family HMM PF01235; sodium:alanine symporter family protein 388995 930344 SP_0408 Streptococcus pneumoniae TIGR4 sodium:alanine symporter family protein NP_344931.1 387673 D 170187 CDS NP_344932.1 15900328 930345 389213..389761 1 NC_003028.3 hypothetical protein 389761 930345 SP_0409 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344932.1 389213 D 170187 CDS NP_344933.1 15900329 930346 389871..390770 1 NC_003028.3 exfoliative toxin 390770 930346 SP_0410 Streptococcus pneumoniae TIGR4 exfoliative toxin NP_344933.1 389871 D 170187 CDS NP_344934.1 15900330 930347 complement(390795..392069) 1 NC_003028.3 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 392069 930347 SP_0411 Streptococcus pneumoniae TIGR4 seryl-tRNA synthetase NP_344934.1 390795 R 170187 CDS NP_344935.1 15900331 930348 complement(392282..392653) 1 NC_003028.3 hypothetical protein 392653 930348 SP_0412 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344935.1 392282 R 170187 CDS NP_344936.1 15900332 930349 complement(392656..394020) 1 NC_003028.3 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase 394020 930349 SP_0413 Streptococcus pneumoniae TIGR4 aspartate kinase NP_344936.1 392656 R 170187 CDS NP_344937.1 15900333 930350 complement(394104..394208) 1 NC_003028.3 hypothetical protein 394208 930350 SP_0414 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344937.1 394104 R 170187 CDS NP_344938.1 15900334 930351 394345..395130 1 NC_003028.3 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 395130 930351 SP_0415 Streptococcus pneumoniae TIGR4 enoyl-CoA hydratase NP_344938.1 394345 D 170187 CDS NP_344939.1 15900335 930352 395224..395658 1 NC_003028.3 MarR family transcriptional regulator 395658 930352 SP_0416 Streptococcus pneumoniae TIGR4 MarR family transcriptional regulator NP_344939.1 395224 D 170187 CDS NP_344940.1 15900336 930353 395658..396632 1 NC_003028.3 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 396632 930353 SP_0417 Streptococcus pneumoniae TIGR4 3-oxoacyl-ACP synthase NP_344940.1 395658 D 170187 CDS NP_344941.1 15900337 930354 396692..396916 1 NC_003028.3 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 396916 acpP 930354 acpP Streptococcus pneumoniae TIGR4 acyl carrier protein NP_344941.1 396692 D 170187 CDS NP_344942.1 15900338 930355 397035..398009 1 NC_003028.3 enoyl-ACP reductase 398009 930355 SP_0419 Streptococcus pneumoniae TIGR4 enoyl-ACP reductase NP_344942.1 397035 D 170187 CDS NP_344943.1 15900339 930356 398002..398922 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00128; ACP S-malonyltransferase 398922 930356 SP_0420 Streptococcus pneumoniae TIGR4 ACP S-malonyltransferase NP_344943.1 398002 D 170187 CDS NP_344944.1 15900340 930357 398956..399687 1 NC_003028.3 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 399687 fabG 930357 fabG Streptococcus pneumoniae TIGR4 3-ketoacyl-ACP reductase NP_344944.1 398956 D 170187 CDS NP_344945.1 15900341 930358 399709..400944 1 NC_003028.3 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 400944 930358 SP_0422 Streptococcus pneumoniae TIGR4 3-oxoacyl-ACP synthase NP_344945.1 399709 D 170187 CDS NP_344946.1 15900342 930359 400947..401432 1 NC_003028.3 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 401432 930359 SP_0423 Streptococcus pneumoniae TIGR4 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit NP_344946.1 400947 D 170187 CDS NP_344947.1 15900343 930360 401429..401851 1 NC_003028.3 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 401851 fabZ 930360 fabZ Streptococcus pneumoniae TIGR4 (3R)-hydroxymyristoyl-ACP dehydratase NP_344947.1 401429 D 170187 CDS NP_344948.1 15900344 930361 401863..403230 1 NC_003028.3 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 403230 930361 SP_0425 Streptococcus pneumoniae TIGR4 acetyl-CoA carboxylase biotin carboxylase subunit NP_344948.1 401863 D 170187 CDS NP_344949.1 15900345 930362 403267..404133 1 NC_003028.3 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 404133 930362 SP_0426 Streptococcus pneumoniae TIGR4 acetyl-CoA carboxylase subunit beta NP_344949.1 403267 D 170187 CDS NP_344950.1 15900346 930363 404130..404897 1 NC_003028.3 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha 404897 930363 SP_0427 Streptococcus pneumoniae TIGR4 acetyl-CoA carboxylase subunit alpha NP_344950.1 404130 D 170187 CDS NP_344951.1 15900347 930364 404908..405015 1 NC_003028.3 hypothetical protein 405015 930364 SP_0428 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344951.1 404908 D 170187 CDS NP_344952.1 15900348 930365 405056..405241 1 NC_003028.3 hypothetical protein 405241 930365 SP_0429 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344952.1 405056 D 170187 CDS NP_344953.1 15900349 930366 405214..405732 1 NC_003028.3 hypothetical protein 405732 930366 SP_0430 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344953.1 405214 D 170187 CDS NP_344954.1 15900350 930367 405745..405981 1 NC_003028.3 similar to GB:AL009126; identified by sequence similarity; hypothetical protein 405981 930367 SP_0431 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344954.1 405745 D 170187 CDS NP_344955.1 15900351 930369 complement(407504..407926) 1 NC_003028.3 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 407926 nusB 930369 nusB Streptococcus pneumoniae TIGR4 transcription antitermination protein NusB NP_344955.1 407504 R 170187 CDS NP_344956.1 15900352 930370 complement(407919..408308) 1 NC_003028.3 hypothetical protein 408308 930370 SP_0434 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344956.1 407919 R 170187 CDS NP_344957.1 15900353 930371 complement(408330..408890) 1 NC_003028.3 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 408890 930371 SP_0435 Streptococcus pneumoniae TIGR4 elongation factor P NP_344957.1 408330 R 170187 CDS NP_344958.1 15900354 930372 complement(409019..410461) 1 NC_003028.3 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 410461 gatB 930372 gatB Streptococcus pneumoniae TIGR4 aspartyl/glutamyl-tRNA amidotransferase subunit B NP_344958.1 409019 R 170187 CDS NP_344959.1 15900355 930373 complement(410461..411927) 1 NC_003028.3 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 411927 gatA 930373 gatA Streptococcus pneumoniae TIGR4 aspartyl/glutamyl-tRNA amidotransferase subunit A NP_344959.1 410461 R 170187 CDS NP_344960.1 15900356 930375 complement(411927..412229) 1 NC_003028.3 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 412229 gatC 930375 gatC Streptococcus pneumoniae TIGR4 aspartyl/glutamyl-tRNA amidotransferase subunit C NP_344960.1 411927 R 170187 CDS NP_344961.1 15900357 930376 412442..413986 1 NC_003028.3 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 413986 prfC 930376 prfC Streptococcus pneumoniae TIGR4 peptide chain release factor 3 NP_344961.1 412442 D 170187 CDS NP_344962.1 15900358 930378 414869..415057 1 NC_003028.3 required for 70S ribosome assembly; 50S ribosomal protein L28 415057 rpmB 930378 rpmB Streptococcus pneumoniae TIGR4 50S ribosomal protein L28 NP_344962.1 414869 D 170187 CDS NP_344963.1 15900359 930379 415214..415579 1 NC_003028.3 hypothetical protein 415579 930379 SP_0442 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344963.1 415214 D 170187 CDS NP_344964.1 15900360 930380 415582..417249 1 NC_003028.3 hypothetical protein 417249 930380 SP_0443 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344964.1 415582 D 170187 CDS NP_344965.1 15900361 930382 complement(417236..417337) 1 NC_003028.3 hypothetical protein 417337 930382 SP_0444 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344965.1 417236 R 170187 CDS NP_344966.1 15900362 930383 417449..419149 1 NC_003028.3 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit 419149 930383 SP_0445 Streptococcus pneumoniae TIGR4 acetolactate synthase catalytic subunit NP_344966.1 417449 D 170187 CDS NP_344967.1 15900363 930384 419142..419618 1 NC_003028.3 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 419618 ilvH 930384 ilvH Streptococcus pneumoniae TIGR4 acetolactate synthase 3 regulatory subunit NP_344967.1 419142 D 170187 CDS NP_344968.1 15900364 930385 419696..420706 1 NC_003028.3 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 420706 930385 SP_0447 Streptococcus pneumoniae TIGR4 ketol-acid reductoisomerase NP_344968.1 419696 D 170187 CDS NP_344969.1 15900365 930386 420783..421049 1 NC_003028.3 hypothetical protein 421049 930386 SP_0448 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344969.1 420783 D 170187 CDS NP_344970.1 15900366 930387 421287..421643 1 NC_003028.3 hypothetical protein 421643 930387 SP_0449 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344970.1 421287 D 170187 CDS NP_344971.1 15900367 930388 421693..422943 1 NC_003028.3 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 422943 930388 SP_0450 Streptococcus pneumoniae TIGR4 threonine dehydratase NP_344971.1 421693 D 170187 CDS NP_344972.1 15900368 930389 423678..423893 1 NC_003028.3 hypothetical protein 423893 930389 SP_0451 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344972.1 423678 D 170187 CDS NP_344973.1 15900369 930390 complement(424002..424742) 1 NC_003028.3 amino acid ABC transporter ATP-binding protein 424742 930390 SP_0452 Streptococcus pneumoniae TIGR4 amino acid ABC transporter ATP-binding protein NP_344973.1 424002 R 170187 CDS NP_344974.1 15900370 930391 complement(424742..426307) 1 NC_003028.3 amino acid ABC transporter amino acid-binding protein/permease 426307 930391 SP_0453 Streptococcus pneumoniae TIGR4 amino acid ABC transporter amino acid-binding protein/permease NP_344974.1 424742 R 170187 CDS NP_344975.1 15900371 930392 426442..428334 1 NC_003028.3 hypothetical protein 428334 930392 SP_0454 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344975.1 426442 D 170187 CDS NP_344976.1 15900372 930393 complement(428331..428501) 1 NC_003028.3 hypothetical protein 428501 930393 SP_0455 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344976.1 428331 R 170187 CDS NP_344977.1 15900373 930395 429907..430752 1 NC_003028.3 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 430752 uppP 930395 uppP Streptococcus pneumoniae TIGR4 UDP pyrophosphate phosphatase NP_344977.1 429907 D 170187 CDS NP_344978.1 15900374 930396 complement(430899..431933) 1 NC_003028.3 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 431933 930396 SP_0458 Streptococcus pneumoniae TIGR4 DNA polymerase IV NP_344978.1 430899 R 170187 CDS NP_344979.1 15900375 930397 432308..434632 1 NC_003028.3 identified by match to PFAM protein family HMM PF01228; formate acetyltransferase 434632 930397 SP_0459 Streptococcus pneumoniae TIGR4 formate acetyltransferase NP_344979.1 432308 D 170187 CDS NP_344980.1 15900376 930398 complement(434770..436038) 1 NC_003028.3 IS1167, transposase 436038 930398 SP_0460 Streptococcus pneumoniae TIGR4 IS1167, transposase NP_344980.1 434770 R 170187 CDS NP_344981.1 15900377 930399 complement(436303..437832) 1 NC_003028.3 similar to GP:1289510; identified by sequence similarity; transcriptional regulator 437832 930399 SP_0461 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_344981.1 436303 R 170187 CDS NP_344982.1 15900378 930400 438327..441008 1 NC_003028.3 cell wall surface anchor family protein 441008 930400 SP_0462 Streptococcus pneumoniae TIGR4 cell wall surface anchor family protein NP_344982.1 438327 D 170187 CDS NP_344983.1 15900379 930401 441232..443229 1 NC_003028.3 identified by match to PFAM protein family HMM PF00746; cell wall surface anchor family protein 443229 930401 SP_0463 Streptococcus pneumoniae TIGR4 cell wall surface anchor family protein NP_344983.1 441232 D 170187 CDS NP_344984.1 15900380 930402 443276..444457 1 NC_003028.3 similar to PID:666069; identified by sequence similarity; cell wall surface anchor family protein 444457 930402 SP_0464 Streptococcus pneumoniae TIGR4 cell wall surface anchor family protein NP_344984.1 443276 D 170187 CDS NP_344985.1 15900381 930403 complement(444676..444807) 1 NC_003028.3 hypothetical protein 444807 930403 SP_0465 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344985.1 444676 R 170187 CDS NP_344986.1 15900382 930404 444858..445697 1 NC_003028.3 similar to GP:3036999; identified by sequence similarity; sortase 445697 930404 SP_0466 Streptococcus pneumoniae TIGR4 sortase NP_344986.1 444858 D 170187 CDS NP_344987.1 15900383 930405 445792..446577 1 NC_003028.3 similar to GP:3036999; identified by sequence similarity; sortase 446577 930405 SP_0467 Streptococcus pneumoniae TIGR4 sortase NP_344987.1 445792 D 170187 CDS NP_344988.1 15900384 930406 446564..447415 1 NC_003028.3 similar to GP:3036999; identified by sequence similarity; sortase 447415 930406 SP_0468 Streptococcus pneumoniae TIGR4 sortase NP_344988.1 446564 D 170187 CDS NP_344989.1 15900385 930408 complement(448879..449028) 1 NC_003028.3 hypothetical protein 449028 930408 SP_0470 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344989.1 448879 R 170187 CDS NP_344990.1 15900386 930409 complement(449021..449305) 1 NC_003028.3 hypothetical protein 449305 930409 SP_0471 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344990.1 449021 R 170187 CDS NP_344991.1 15900387 930410 449697..449870 1 NC_003028.3 hypothetical protein 449870 930410 SP_0472 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344991.1 449697 D 170187 CDS NP_344992.1 15900388 930411 complement(450739..451962) 1 NC_003028.3 ROK family protein 451962 930411 SP_0473 Streptococcus pneumoniae TIGR4 ROK family protein NP_344992.1 450739 R 170187 CDS NP_344993.1 15900389 930412 452130..453452 1 NC_003028.3 identified by match to PFAM protein family HMM PF02378; PTS system cellobiose-specific transporter subunit IIC 453452 930412 SP_0474 Streptococcus pneumoniae TIGR4 PTS system cellobiose-specific transporter subunit IIC NP_344993.1 452130 D 170187 CDS NP_344994.1 15900390 930413 453400..455340 1 NC_003028.3 hypothetical protein 455340 930413 SP_0475 Streptococcus pneumoniae TIGR4 hypothetical protein NP_344994.1 453400 D 170187 CDS NP_344995.1 15900391 930414 455508..455852 1 NC_003028.3 PTS system lactose-specific transporter subunit IIA 455852 930414 SP_0476 Streptococcus pneumoniae TIGR4 PTS system lactose-specific transporter subunit IIA NP_344995.1 455508 D 170187 CDS NP_344996.1 15900392 930415 455862..457274 1 NC_003028.3 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 457274 930415 SP_0477 Streptococcus pneumoniae TIGR4 6-phospho-beta-galactosidase NP_344996.1 455862 D 170187 CDS NP_344997.1 15900393 930416 457343..459022 1 NC_003028.3 PTS system lactose-specific transporter subunit IIBC 459022 930416 SP_0478 Streptococcus pneumoniae TIGR4 PTS system lactose-specific transporter subunit IIBC NP_344997.1 457343 D 170187 CDS NP_344998.1 15900394 930417 complement(459148..460587) 1 NC_003028.3 Trk family potassium uptake protein 460587 930417 SP_0479 Streptococcus pneumoniae TIGR4 Trk family potassium uptake protein NP_344998.1 459148 R 170187 CDS NP_344999.1 15900395 930418 complement(460591..461940) 1 NC_003028.3 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 461940 trkA 930418 trkA Streptococcus pneumoniae TIGR4 potassium transporter peripheral membrane protein NP_344999.1 460591 R 170187 CDS NP_345000.1 15900396 930419 462101..462976 1 NC_003028.3 hypothetical protein 462976 930419 SP_0481 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345000.1 462101 D 170187 CDS NP_345001.1 15900397 930420 462991..463539 1 NC_003028.3 hypothetical protein 463539 930420 SP_0482 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345001.1 462991 D 170187 CDS NP_345002.1 15900398 930421 463905..465587 1 NC_003028.3 ABC transporter ATP-binding protein 465587 930421 SP_0483 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345002.1 463905 D 170187 CDS NP_345003.1 15900399 930422 465572..466402 1 NC_003028.3 hypothetical protein 466402 930422 SP_0484 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345003.1 465572 D 170187 CDS NP_345004.1 15900400 930423 466595..467098 1 NC_003028.3 RNA methyltransferase 467098 930423 SP_0486 Streptococcus pneumoniae TIGR4 RNA methyltransferase NP_345004.1 466595 D 170187 CDS NP_345005.1 15900401 930424 complement(467295..467513) 1 NC_003028.3 hypothetical protein 467513 930424 SP_0487 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345005.1 467295 R 170187 CDS NP_345006.1 15900402 930425 467551..468114 1 NC_003028.3 hypothetical protein 468114 930425 SP_0488 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345006.1 467551 D 170187 CDS NP_345007.1 15900403 930426 468104..468754 1 NC_003028.3 identified by match to PFAM protein family HMM PF01569; PAP2 family protein 468754 930426 SP_0489 Streptococcus pneumoniae TIGR4 PAP2 family protein NP_345007.1 468104 D 170187 CDS NP_345008.1 15900404 930427 468782..469171 1 NC_003028.3 hypothetical protein 469171 930427 SP_0490 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345008.1 468782 D 170187 CDS NP_345009.1 15900405 930428 469176..469331 1 NC_003028.3 hypothetical protein 469331 930428 SP_0491 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345009.1 469176 D 170187 CDS NP_345010.1 15900406 930429 469303..469626 1 NC_003028.3 hypothetical protein 469626 930429 SP_0492 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345010.1 469303 D 170187 CDS NP_345011.3 255964980 930431 469739..470341 1 NC_003028.3 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 470341 930431 SP_0493 Streptococcus pneumoniae TIGR4 DNA-directed RNA polymerase subunit delta NP_345011.3 469739 D 170187 CDS NP_345012.1 15900408 930432 470731..472338 1 NC_003028.3 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 472338 pyrG 930432 pyrG Streptococcus pneumoniae TIGR4 CTP synthetase NP_345012.1 470731 D 170187 CDS NP_345013.1 15900409 930433 complement(472994..474340) 1 NC_003028.3 similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 474340 930433 SP_0495 Streptococcus pneumoniae TIGR4 IS1380-Spn1 transposase NP_345013.1 472994 R 170187 CDS NP_345014.1 15900410 930434 complement(474605..476236) 1 NC_003028.3 Na/Pi cotransporter II-like protein 476236 930434 SP_0496 Streptococcus pneumoniae TIGR4 Na/Pi cotransporter II-like protein NP_345014.1 474605 R 170187 CDS NP_345015.1 15900411 930435 476438..476548 1 NC_003028.3 hypothetical protein 476548 930435 SP_0497 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345015.1 476438 D 170187 CDS NP_345016.1 15900412 930436 476529..481508 1 NC_003028.3 identified by match to PFAM protein family HMM PF00746; endo-beta-N-acetylglucosaminidase 481508 930436 SP_0498 Streptococcus pneumoniae TIGR4 endo-beta-N-acetylglucosaminidase NP_345016.1 476529 D 170187 CDS NP_345017.1 15900413 930437 481598..482794 1 NC_003028.3 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 482794 pgk 930437 pgk Streptococcus pneumoniae TIGR4 phosphoglycerate kinase NP_345017.1 481598 D 170187 CDS NP_345018.1 15900414 930438 482930..483457 1 NC_003028.3 similar to GB:AL009126; identified by sequence similarity; hypothetical protein 483457 930438 SP_0500 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345018.1 482930 D 170187 CDS NP_345019.1 15900415 930439 483534..483890 1 NC_003028.3 MerR family transcriptional regulator 483890 930439 SP_0501 Streptococcus pneumoniae TIGR4 MerR family transcriptional regulator NP_345019.1 483534 D 170187 CDS NP_345020.1 15900416 930440 483927..485273 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00653; glutamine synthetase, type I 485273 930440 SP_0502 Streptococcus pneumoniae TIGR4 glutamine synthetase, type I NP_345020.1 483927 D 170187 CDS NP_345021.1 15900417 930441 complement(485369..485488) 1 NC_003028.3 hypothetical protein 485488 930441 SP_0503 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345021.1 485369 R 170187 CDS NP_345022.1 15900418 930442 485746..485883 1 NC_003028.3 hypothetical protein 485883 930442 SP_0504 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345022.1 485746 D 170187 CDS NP_345023.1 15900419 930443 486054..487334 1 NC_003028.3 type I restriction-modification system subunit S 487334 930443 SP_0505 Streptococcus pneumoniae TIGR4 type I restriction-modification system subunit S NP_345023.1 486054 D 170187 CDS NP_345024.1 15900420 930444 487391..488188 1 NC_003028.3 phage integrase family integrase/recombinase 488188 930444 SP_0506 Streptococcus pneumoniae TIGR4 phage integrase family integrase/recombinase NP_345024.1 487391 D 170187 CDS NP_345025.1 15900421 930445 488259..488798 1 NC_003028.3 type I restriction-modification system subunit S 488798 930445 SP_0507 Streptococcus pneumoniae TIGR4 type I restriction-modification system subunit S NP_345025.1 488259 D 170187 CDS NP_345026.1 15900422 930446 complement(488752..490320) 1 NC_003028.3 type I restriction-modification system subunit S 490320 930446 SP_0508 Streptococcus pneumoniae TIGR4 type I restriction-modification system subunit S NP_345026.1 488752 R 170187 CDS NP_345027.1 15900423 930447 complement(490320..491783) 1 NC_003028.3 type I restriction-modification system, M subunit 491783 930447 SP_0509 Streptococcus pneumoniae TIGR4 type I restriction-modification system, M subunit NP_345027.1 490320 R 170187 CDS NP_345028.1 15900424 930448 complement(491796..494129) 1 NC_003028.3 type I restriction-modification system, R subunit 494129 930448 SP_0510 Streptococcus pneumoniae TIGR4 type I restriction-modification system, R subunit NP_345028.1 491796 R 170187 CDS NP_345029.1 15900425 930449 complement(494480..494608) 1 NC_003028.3 hypothetical protein 494608 930449 SP_0511 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345029.1 494480 R 170187 CDS NP_345030.1 15900426 930450 494592..494702 1 NC_003028.3 hypothetical protein 494702 930450 SP_0512 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345030.1 494592 D 170187 CDS NP_345031.1 15900427 930451 494737..494928 1 NC_003028.3 hypothetical protein 494928 930451 SP_0513 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345031.1 494737 D 170187 CDS NP_345032.1 15900428 930452 494900..495247 1 NC_003028.3 hypothetical protein 495247 930452 SP_0514 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345032.1 494900 D 170187 CDS NP_345033.1 15900429 930453 495411..496445 1 NC_003028.3 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 496445 hrcA 930453 hrcA Streptococcus pneumoniae TIGR4 heat-inducible transcription repressor NP_345033.1 495411 D 170187 CDS NP_345034.1 15900430 930454 496472..496996 1 NC_003028.3 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 496996 930454 SP_0516 Streptococcus pneumoniae TIGR4 heat shock protein GrpE NP_345034.1 496472 D 170187 CDS NP_345035.1 15900431 930455 497485..499308 1 NC_003028.3 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 499308 dnaK 930455 dnaK Streptococcus pneumoniae TIGR4 molecular chaperone DnaK NP_345035.1 497485 D 170187 CDS NP_345036.1 15900432 930456 499310..499456 1 NC_003028.3 hypothetical protein 499456 930456 SP_0518 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345036.1 499310 D 170187 CDS NP_345037.1 15900433 930457 500067..501203 1 NC_003028.3 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 501203 930457 SP_0519 Streptococcus pneumoniae TIGR4 molecular chaperone DnaJ NP_345037.1 500067 D 170187 CDS NP_345038.1 15900434 930459 complement(501893..502180) 1 NC_003028.3 hypothetical protein 502180 930459 SP_0520 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345038.1 501893 R 170187 CDS NP_345039.1 15900435 930460 complement(502190..502600) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01230; HIT family protein 502600 930460 SP_0521 Streptococcus pneumoniae TIGR4 HIT family protein NP_345039.1 502190 R 170187 CDS NP_345040.1 15900436 930461 502668..503399 1 NC_003028.3 ABC transporter ATP-binding protein 503399 930461 SP_0522 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345040.1 502668 D 170187 CDS NP_345041.1 15900437 930463 503396..504445 1 NC_003028.3 similar to PID:1177254 SP:P55340 PID:2226114 GB:AL009126; identified by sequence similarity; ABC transporter permease 504445 930463 SP_0523 Streptococcus pneumoniae TIGR4 ABC transporter permease NP_345041.1 503396 D 170187 CDS NP_345042.1 15900438 930464 complement(504613..504942) 1 NC_003028.3 similar to GP:9798558; identified by sequence similarity; BlpT protein, fusion 504942 930464 SP_0524 Streptococcus pneumoniae TIGR4 BlpT protein, fusion NP_345042.1 504613 R 170187 CDS NP_345043.1 15900439 930465 505218..505556 1 NC_003028.3 similar to GP:9798559; identified by sequence similarity; BlpS protein 505556 930465 SP_0525 Streptococcus pneumoniae TIGR4 BlpS protein NP_345043.1 505218 D 170187 CDS NP_345044.1 15900440 930466 505561..506298 1 NC_003028.3 response regulator BlpR 506298 930466 SP_0526 Streptococcus pneumoniae TIGR4 response regulator BlpR NP_345044.1 505561 D 170187 CDS NP_345045.1 15900441 930467 506312..507652 1 NC_003028.3 similar to GP:5830551; identified by sequence similarity; sensor histidine kinase BlpH 507652 930467 SP_0527 Streptococcus pneumoniae TIGR4 sensor histidine kinase BlpH NP_345045.1 506312 D 170187 CDS NP_345046.1 15900442 930468 complement(507723..507851) 1 NC_003028.3 similar to GP:9798562; identified by sequence similarity; peptide pheromone BlpC 507851 930468 SP_0528 Streptococcus pneumoniae TIGR4 peptide pheromone BlpC NP_345046.1 507723 R 170187 CDS NP_345047.1 15900443 930469 complement(507908..509269) 1 NC_003028.3 BlpC ABC transporter 509269 930469 SP_0529 Streptococcus pneumoniae TIGR4 BlpC ABC transporter NP_345047.1 507908 R 170187 CDS NP_345048.1 15900444 930471 511719..511916 1 NC_003028.3 similar to GP:9798565; identified by sequence similarity; bacteriocin BlpI 511916 930471 SP_0531 Streptococcus pneumoniae TIGR4 bacteriocin BlpI NP_345048.1 511719 D 170187 CDS NP_345049.1 15900445 930472 512383..512652 1 NC_003028.3 similar to GP:9798566; identified by sequence similarity; bacteriocin BlpJ 512652 930472 SP_0532 Streptococcus pneumoniae TIGR4 bacteriocin BlpJ NP_345049.1 512383 D 170187 CDS NP_345050.1 15900446 930473 512721..512951 1 NC_003028.3 similar to GP:9798567; identified by sequence similarity; bacteriocin BlpK 512951 930473 SP_0533 Streptococcus pneumoniae TIGR4 bacteriocin BlpK NP_345050.1 512721 D 170187 CDS NP_345051.1 15900447 930474 513186..513302 1 NC_003028.3 hypothetical protein 513302 930474 SP_0534 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345051.1 513186 D 170187 CDS NP_345052.1 15900448 930475 513370..513534 1 NC_003028.3 hypothetical protein 513534 930475 SP_0535 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345052.1 513370 D 170187 CDS NP_345053.1 15900449 930476 513531..513935 1 NC_003028.3 similar to GP:9798568; identified by sequence similarity; immunity protein BlpL 513935 930476 SP_0536 Streptococcus pneumoniae TIGR4 immunity protein BlpL NP_345053.1 513531 D 170187 CDS NP_345054.1 15900450 930477 514138..514527 1 NC_003028.3 similar to PID:763133; identified by sequence similarity; IS1381 transposase protein A 514527 930477 SP_0537 Streptococcus pneumoniae TIGR4 IS1381 transposase protein A NP_345054.1 514138 D 170187 CDS NP_345055.1 15900451 930478 514553..514942 1 NC_003028.3 similar to PID:763133; identified by sequence similarity; IS1381 transposase protein B 514942 930478 SP_0538 Streptococcus pneumoniae TIGR4 IS1381 transposase protein B NP_345055.1 514553 D 170187 CDS NP_345056.1 15900452 930479 515092..515346 1 NC_003028.3 similar to GP:9798569; identified by sequence similarity; bacteriocin BlpM 515346 930479 SP_0539 Streptococcus pneumoniae TIGR4 bacteriocin BlpM NP_345056.1 515092 D 170187 CDS NP_345057.1 15900453 930481 515362..515565 1 NC_003028.3 similar to GP:9798570; identified by sequence similarity; BlpN protein 515565 930481 SP_0540 Streptococcus pneumoniae TIGR4 BlpN protein NP_345057.1 515362 D 170187 CDS NP_345058.1 15900454 930482 515809..515958 1 NC_003028.3 similar to GP:9798571; identified by sequence similarity; bacteriocin BlpO 515958 930482 SP_0541 Streptococcus pneumoniae TIGR4 bacteriocin BlpO NP_345058.1 515809 D 170187 CDS NP_345059.1 15900455 930483 515940..516059 1 NC_003028.3 hypothetical protein 516059 930483 SP_0542 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345059.1 515940 D 170187 CDS NP_345060.1 15900456 930484 516700..516867 1 NC_003028.3 hypothetical protein 516867 930484 SP_0543 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345060.1 516700 D 170187 CDS NP_345061.1 15900457 930485 516952..517350 1 NC_003028.3 similar to GP:9798572; identified by sequence similarity; immunity protein BlpX 517350 930485 SP_0544 Streptococcus pneumoniae TIGR4 immunity protein BlpX NP_345061.1 516952 D 170187 CDS NP_345062.1 15900458 930486 517402..518091 1 NC_003028.3 similar to PID:1495680; identified by sequence similarity; immunity protein BlpY 518091 930486 SP_0545 Streptococcus pneumoniae TIGR4 immunity protein BlpY NP_345062.1 517402 D 170187 CDS NP_345063.1 15900459 930487 518133..518366 1 NC_003028.3 similar to GP:9798574; identified by sequence similarity; hypothetical protein 518366 930487 SP_0546 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345063.1 518133 D 170187 CDS NP_345064.1 15900460 930488 518517..519128 1 NC_003028.3 similar to GB:AL009126; identified by sequence similarity; hypothetical protein 519128 930488 SP_0547 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345064.1 518517 D 170187 CDS NP_345065.1 15900461 930489 complement(519222..519344) 1 NC_003028.3 hypothetical protein 519344 930489 SP_0548 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345065.1 519222 R 170187 CDS NP_345066.1 15900462 930490 519352..520083 1 NC_003028.3 hypothetical protein 520083 930490 SP_0549 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345066.1 519352 D 170187 CDS NP_345067.1 15900463 930494 520080..520715 1 NC_003028.3 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 520715 trmB 930494 trmB Streptococcus pneumoniae TIGR4 tRNA (guanine-N(7)-)-methyltransferase NP_345067.1 520080 D 170187 CDS NP_345068.1 15900464 930495 520841..521320 1 NC_003028.3 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 521320 930495 SP_0552 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345068.1 520841 D 170187 CDS NP_345069.1 15900465 930496 521364..522500 1 NC_003028.3 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 522500 nusA 930496 nusA Streptococcus pneumoniae TIGR4 transcription elongation factor NusA NP_345069.1 521364 D 170187 CDS NP_345070.1 15900466 930497 522522..522815 1 NC_003028.3 hypothetical protein 522815 930497 SP_0554 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345070.1 522522 D 170187 CDS NP_345071.1 15900467 930498 522808..523107 1 NC_003028.3 identified by match to PFAM protein family HMM PF01248; hypothetical protein 523107 930498 SP_0555 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345071.1 522808 D 170187 CDS NP_345072.1 15900468 930499 523124..526000 1 NC_003028.3 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 526000 infB 930499 infB Streptococcus pneumoniae TIGR4 translation initiation factor IF-2 NP_345072.1 523124 D 170187 CDS NP_345073.1 15900469 930500 526251..526601 1 NC_003028.3 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 526601 rbfA 930500 rbfA Streptococcus pneumoniae TIGR4 ribosome-binding factor A NP_345073.1 526251 D 170187 CDS NP_345074.1 15900470 930501 526844..527659 1 NC_003028.3 hypothetical protein 527659 930501 SP_0558 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345074.1 526844 D 170187 CDS NP_345075.1 15900471 930502 527661..527843 1 NC_003028.3 hypothetical protein 527843 930502 SP_0559 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345075.1 527661 D 170187 CDS NP_345076.1 15900472 930504 complement(527796..528029) 1 NC_003028.3 hypothetical protein 528029 930504 SP_0560 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345076.1 527796 R 170187 CDS NP_345077.1 15900473 930505 528291..528536 1 NC_003028.3 similar to GB:AE000782; identified by sequence similarity; hypothetical protein 528536 930505 SP_0561 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345077.1 528291 D 170187 CDS NP_345078.1 15900474 930506 528536..529870 1 NC_003028.3 hypothetical protein 529870 930506 SP_0562 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345078.1 528536 D 170187 CDS NP_345079.1 15900475 930507 529880..530134 1 NC_003028.3 hypothetical protein 530134 930507 SP_0563 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345079.1 529880 D 170187 CDS NP_345080.1 15900476 930508 530230..530625 1 NC_003028.3 hypothetical protein 530625 930508 SP_0564 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345080.1 530230 D 170187 CDS NP_345081.1 15900477 930509 531038..531487 1 NC_003028.3 similar to GP:8927331; identified by sequence similarity; hypothetical protein 531487 930509 SP_0565 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345081.1 531038 D 170187 CDS NP_345082.1 15900478 930510 531474..532034 1 NC_003028.3 acetyltransferase 532034 930510 SP_0566 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345082.1 531474 D 170187 CDS NP_345083.1 15900479 930511 532019..532612 1 NC_003028.3 hypothetical protein 532612 930511 SP_0567 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345083.1 532019 D 170187 CDS NP_345084.1 15900480 930512 532605..535256 1 NC_003028.3 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 535256 valS 930512 valS Streptococcus pneumoniae TIGR4 valyl-tRNA synthetase NP_345084.1 532605 D 170187 CDS YP_003104753.1 255964981 930513 535337..535501 1 NC_003028.3 type II DNA modification methyltransferase 535501 930513 SP_0569 Streptococcus pneumoniae TIGR4 type II DNA modification methyltransferase YP_003104753.1 535337 D 170187 CDS NP_345085.1 15900481 930514 535552..537156 1 NC_003028.3 similar to GP:2687741; identified by sequence similarity; hypothetical protein 537156 930514 SP_0570 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345085.1 535552 D 170187 CDS NP_345086.1 15900482 930515 537536..538339 1 NC_003028.3 cell filamentation protein Fic-like protein 538339 930515 SP_0571 Streptococcus pneumoniae TIGR4 cell filamentation protein Fic-like protein NP_345086.1 537536 D 170187 CDS NP_345087.1 15900483 930517 539917..540078 1 NC_003028.3 hypothetical protein 540078 930517 SP_0573 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345087.1 539917 D 170187 CDS NP_345088.1 15900484 930518 540202..541032 1 NC_003028.3 hypothetical protein 541032 930518 SP_0574 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345088.1 540202 D 170187 CDS NP_345089.1 15900485 930519 541218..542864 1 NC_003028.3 helicase 542864 930519 SP_0575 Streptococcus pneumoniae TIGR4 helicase NP_345089.1 541218 D 170187 CDS NP_345090.1 15900486 930520 543164..544003 1 NC_003028.3 identified by match to PFAM protein family HMM PF00874; transcription antiterminator Lict 544003 930520 SP_0576 Streptococcus pneumoniae TIGR4 transcription antiterminator Lict NP_345090.1 543164 D 170187 CDS NP_345091.1 15900487 930521 544021..545859 1 NC_003028.3 PTS system beta-glucosides-specific transporter subunit IIABC 545859 930521 SP_0577 Streptococcus pneumoniae TIGR4 PTS system beta-glucosides-specific transporter subunit IIABC NP_345091.1 544021 D 170187 CDS NP_345092.1 15900488 930522 545872..547287 1 NC_003028.3 6-phospho-beta-glucosidase 547287 930522 SP_0578 Streptococcus pneumoniae TIGR4 6-phospho-beta-glucosidase NP_345092.1 545872 D 170187 CDS NP_345093.1 15900489 930523 547769..548815 1 NC_003028.3 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 548815 pheS 930523 pheS Streptococcus pneumoniae TIGR4 phenylalanyl-tRNA synthetase subunit alpha NP_345093.1 547769 D 170187 CDS NP_345094.1 15900490 930524 548815..549324 1 NC_003028.3 acetyltransferase 549324 930524 SP_0580 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345094.1 548815 D 170187 CDS NP_345095.1 15900491 930525 549401..551806 1 NC_003028.3 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 551806 pheT 930525 pheT Streptococcus pneumoniae TIGR4 phenylalanyl-tRNA synthetase subunit beta NP_345095.1 549401 D 170187 CDS NP_345096.1 15900492 930528 complement(551874..552875) 1 NC_003028.3 hypothetical protein 552875 930528 SP_0582 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345096.1 551874 R 170187 CDS NP_345097.1 15900493 930530 553626..553838 1 NC_003028.3 transcriptional regulator 553838 930530 SP_0584 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_345097.1 553626 D 170187 CDS NP_345098.1 15900494 930531 554099..556348 1 NC_003028.3 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 556348 930531 SP_0585 Streptococcus pneumoniae TIGR4 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase NP_345098.1 554099 D 170187 CDS NP_345099.1 15900495 930532 556412..557278 1 NC_003028.3 identified by match to PFAM protein family HMM PF02219; 5,10-methylenetetrahydrofolate reductase 557278 930532 SP_0586 Streptococcus pneumoniae TIGR4 5,10-methylenetetrahydrofolate reductase NP_345099.1 556412 D 170187 CDS NP_345100.1 15900496 930533 complement(557460..557729) 1 NC_003028.3 hypothetical protein 557729 930533 SP_0587 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345100.1 557460 R 170187 CDS NP_345101.1 15900497 930534 557963..560176 1 NC_003028.3 identified by match to PFAM protein family HMM PF01138; polynucleotide phosphorylase 560176 930534 SP_0588 Streptococcus pneumoniae TIGR4 polynucleotide phosphorylase NP_345101.1 557963 D 170187 CDS NP_345102.1 15900498 930535 560192..560809 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR01172; serine acetyltransferase 560809 930535 SP_0589 Streptococcus pneumoniae TIGR4 serine acetyltransferase NP_345102.1 560192 D 170187 CDS NP_345103.1 15900499 930536 560821..561705 1 NC_003028.3 acetyltransferase 561705 930536 SP_0590 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345103.1 560821 D 170187 CDS NP_345104.1 15900500 930537 561787..563130 1 NC_003028.3 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 563130 cysS 930537 cysS Streptococcus pneumoniae TIGR4 cysteinyl-tRNA synthetase NP_345104.1 561787 D 170187 CDS NP_345105.1 15900501 930538 563123..563509 1 NC_003028.3 hypothetical protein 563509 930538 SP_0592 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345105.1 563123 D 170187 CDS NP_345106.1 15900502 930539 563513..564397 1 NC_003028.3 hypothetical protein 564397 930539 SP_0593 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345106.1 563513 D 170187 CDS NP_345108.1 15900504 930541 564534..564989 1 NC_003028.3 hypothetical protein 564989 930541 SP_0595 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345108.1 564534 D 170187 CDS NP_345109.1 15900505 930542 564986..565132 1 NC_003028.3 hypothetical protein 565132 930542 SP_0596 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345109.1 564986 D 170187 CDS NP_345110.1 15900506 930545 565789..565953 1 NC_003028.3 hypothetical protein 565953 930545 SP_0598 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345110.1 565789 D 170187 CDS NP_345111.1 15900507 930546 565916..567079 1 NC_003028.3 similar to GP:5712667; identified by sequence similarity; transmembrane protein Vexp1 567079 930546 SP_0599 Streptococcus pneumoniae TIGR4 transmembrane protein Vexp1 NP_345111.1 565916 D 170187 CDS NP_345112.1 15900508 930547 567092..567739 1 NC_003028.3 ABC transporter ATP-binding protein 567739 930547 SP_0600 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345112.1 567092 D 170187 CDS NP_345113.1 15900509 930549 567791..569170 1 NC_003028.3 similar to GP:5712669; identified by sequence similarity; transmembrane protein Vexp3 569170 930549 SP_0601 Streptococcus pneumoniae TIGR4 transmembrane protein Vexp3 NP_345113.1 567791 D 170187 CDS NP_345115.1 15900511 930551 569482..570138 1 NC_003028.3 DNA-binding response regulator VncR 570138 930551 SP_0603 Streptococcus pneumoniae TIGR4 DNA-binding response regulator VncR NP_345115.1 569482 D 170187 CDS NP_345116.1 15900512 930552 570135..571463 1 NC_003028.3 sensor histidine kinase VncS 571463 930552 SP_0604 Streptococcus pneumoniae TIGR4 sensor histidine kinase VncS NP_345116.1 570135 D 170187 CDS NP_345117.1 15900513 930553 571604..572485 1 NC_003028.3 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 572485 930553 SP_0605 Streptococcus pneumoniae TIGR4 fructose-bisphosphate aldolase NP_345117.1 571604 D 170187 CDS NP_345118.1 15900514 930555 complement(572806..574008) 1 NC_003028.3 oxidoreductase 574008 930555 SP_0606 Streptococcus pneumoniae TIGR4 oxidoreductase NP_345118.1 572806 R 170187 CDS NP_345119.1 15900515 930556 complement(574254..574913) 1 NC_003028.3 amino acid ABC transporter permease 574913 930556 SP_0607 Streptococcus pneumoniae TIGR4 amino acid ABC transporter permease NP_345119.1 574254 R 170187 CDS NP_345120.1 15900516 930557 complement(574923..575600) 1 NC_003028.3 amino acid ABC transporter permease 575600 930557 SP_0608 Streptococcus pneumoniae TIGR4 amino acid ABC transporter permease NP_345120.1 574923 R 170187 CDS NP_345121.1 15900517 930558 complement(575613..576377) 1 NC_003028.3 amino acid ABC transporter amino acid-binding protein 576377 930558 SP_0609 Streptococcus pneumoniae TIGR4 amino acid ABC transporter amino acid-binding protein NP_345121.1 575613 R 170187 CDS NP_345122.1 15900518 930559 complement(576417..577175) 1 NC_003028.3 amino acid ABC transporter ATP-binding protein 577175 930559 SP_0610 Streptococcus pneumoniae TIGR4 amino acid ABC transporter ATP-binding protein NP_345122.1 576417 R 170187 CDS NP_345123.2 118090027 930560 577452..579674 1 NC_003028.3 identified by match to PFAM protein family HMM PF02272; single-stranded-DNA-specific exonuclease RecJ 579674 930560 SP_0611 Streptococcus pneumoniae TIGR4 single-stranded-DNA-specific exonuclease RecJ NP_345123.2 577452 D 170187 CDS NP_345124.1 15900520 930561 579708..579806 1 NC_003028.3 hypothetical protein 579806 930561 SP_0612 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345124.1 579708 D 170187 CDS NP_345125.1 15900521 930562 579849..581510 1 NC_003028.3 identified by match to PFAM protein family HMM PF02147; metallo-beta-lactamase superfamily protein 581510 930562 SP_0613 Streptococcus pneumoniae TIGR4 metallo-beta-lactamase superfamily protein NP_345125.1 579849 D 170187 CDS NP_345126.1 15900522 930563 581579..582358 1 NC_003028.3 tributyrin esterase 582358 930563 SP_0614 Streptococcus pneumoniae TIGR4 tributyrin esterase NP_345126.1 581579 D 170187 CDS NP_345127.1 15900523 930564 582470..583690 1 NC_003028.3 similar to GP:7649681; identified by sequence similarity; beta-lactam resistance factor 583690 930564 SP_0615 Streptococcus pneumoniae TIGR4 beta-lactam resistance factor NP_345127.1 582470 D 170187 CDS NP_345128.1 15900524 930565 583695..584927 1 NC_003028.3 similar to GP:7649683; identified by sequence similarity; beta-lactam resistance factor 584927 930565 SP_0616 Streptococcus pneumoniae TIGR4 beta-lactam resistance factor NP_345128.1 583695 D 170187 CDS NP_345129.1 15900525 930566 584985..585707 1 NC_003028.3 hypothetical protein 585707 930566 SP_0617 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345129.1 584985 D 170187 CDS NP_345130.1 15900526 930567 585747..587591 1 NC_003028.3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 587591 uvrC 930567 uvrC Streptococcus pneumoniae TIGR4 excinuclease ABC subunit C NP_345130.1 585747 D 170187 CDS NP_345131.1 15900527 930568 587581..588414 1 NC_003028.3 hypothetical protein 588414 930568 SP_0619 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345131.1 587581 D 170187 CDS NP_345132.1 15900528 930569 complement(588596..589396) 1 NC_003028.3 amino acid ABC transporter amino acid-binding protein 589396 930569 SP_0620 Streptococcus pneumoniae TIGR4 amino acid ABC transporter amino acid-binding protein NP_345132.1 588596 R 170187 CDS NP_345133.1 15900529 930570 589470..589580 1 NC_003028.3 hypothetical protein 589580 930570 SP_0621 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345133.1 589470 D 170187 CDS NP_345134.1 15900530 930571 589567..590172 1 NC_003028.3 identified by match to PFAM protein family HMM PF00881; nitroreductase 590172 930571 SP_0622 Streptococcus pneumoniae TIGR4 nitroreductase NP_345134.1 589567 D 170187 CDS NP_345135.1 15900531 930572 590185..591585 1 NC_003028.3 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 591585 930572 SP_0623 Streptococcus pneumoniae TIGR4 dipeptidase PepV NP_345135.1 590185 D 170187 CDS NP_345136.1 15900532 930573 591639..592217 1 NC_003028.3 hypothetical protein 592217 930573 SP_0624 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345136.1 591639 D 170187 CDS NP_345137.1 15900533 930575 592820..594160 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00796; branched-chain amino acid transport system II carrier protein 594160 930575 SP_0626 Streptococcus pneumoniae TIGR4 branched-chain amino acid transport system II carrier protein NP_345137.1 592820 D 170187 CDS NP_345138.1 15900534 930576 594258..595295 1 NC_003028.3 hypothetical protein 595295 930576 SP_0627 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345138.1 594258 D 170187 CDS NP_345139.1 15900535 930577 595264..595767 1 NC_003028.3 similar to SP:Q04344 PID:1431187 PID:3499; identified by sequence similarity; HIT family protein 595767 930577 SP_0628 Streptococcus pneumoniae TIGR4 HIT family protein NP_345139.1 595264 D 170187 CDS NP_345140.1 15900536 930578 595770..596486 1 NC_003028.3 hypothetical protein 596486 930578 SP_0629 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345140.1 595770 D 170187 CDS NP_345141.1 15900537 930579 596795..597220 1 NC_003028.3 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 597220 rplK 930579 rplK Streptococcus pneumoniae TIGR4 50S ribosomal protein L11 NP_345141.1 596795 D 170187 CDS NP_345142.1 15900538 930580 597427..598116 1 NC_003028.3 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 598116 rplA 930580 rplA Streptococcus pneumoniae TIGR4 50S ribosomal protein L1 NP_345142.1 597427 D 170187 CDS NP_345143.1 15900539 930582 598658..599020 1 NC_003028.3 hypothetical protein 599020 930582 SP_0633 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345143.1 598658 D 170187 CDS NP_345144.1 15900540 930583 599323..599664 1 NC_003028.3 similar to GP:7160903; identified by sequence similarity; hypothetical protein 599664 930583 SP_0634 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345144.1 599323 D 170187 CDS NP_345145.1 15900541 930584 complement(599592..599759) 1 NC_003028.3 hypothetical protein 599759 930584 SP_0635 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345145.1 599592 R 170187 CDS NP_345146.1 15900542 930585 600065..601057 1 NC_003028.3 ABC transporter ATP-binding protein 601057 930585 SP_0636 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345146.1 600065 D 170187 CDS NP_345147.1 15900543 930586 601059..601877 1 NC_003028.3 similar to GP:7636000; identified by sequence similarity; hypothetical protein 601877 930586 SP_0637 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345147.1 601059 D 170187 CDS NP_345148.1 15900544 930587 601879..602664 1 NC_003028.3 hypothetical protein 602664 930587 SP_0638 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345148.1 601879 D 170187 CDS NP_345149.1 15900545 930588 602700..602981 1 NC_003028.3 hypothetical protein 602981 930588 SP_0639 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345149.1 602700 D 170187 CDS NP_345150.1 15900546 930589 602918..603163 1 NC_003028.3 hypothetical protein 603163 930589 SP_0640 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345150.1 602918 D 170187 CDS NP_345151.1 15900547 930590 603895..610317 1 NC_003028.3 identified by match to PFAM protein family HMM PF00746; serine protease 610317 930590 SP_0641 Streptococcus pneumoniae TIGR4 serine protease NP_345151.1 603895 D 170187 CDS NP_345152.1 15900548 930594 612684..613181 1 NC_003028.3 PTS system transporter subunit IIA 613181 930594 SP_0645 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIA NP_345152.1 612684 D 170187 CDS NP_345153.1 15900549 930595 613219..613524 1 NC_003028.3 similar to SP:P37188 GB:X79837 PID:508174 GB:U00096 PID:1736810; identified by sequence similarity; PTS system transporter subunit IIB 613524 930595 SP_0646 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIB NP_345153.1 613219 D 170187 CDS NP_345154.1 15900550 930596 613572..615047 1 NC_003028.3 PTS system transporter subunit IIC 615047 930596 SP_0647 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIC NP_345154.1 613572 D 170187 CDS NP_345155.1 15900551 930597 615442..622143 1 NC_003028.3 identified by match to PFAM protein family HMM PF00703; beta-galactosidase 622143 930597 SP_0648 Streptococcus pneumoniae TIGR4 beta-galactosidase NP_345155.1 615442 D 170187 CDS NP_345156.1 15900552 930599 complement(623457..623777) 1 NC_003028.3 hypothetical protein 623777 930599 SP_0650 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345156.1 623457 R 170187 CDS NP_345157.1 15900553 930601 624848..625405 1 NC_003028.3 hypothetical protein 625405 930601 SP_0652 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345157.1 624848 D 170187 CDS NP_345158.1 15900554 930602 625398..625652 1 NC_003028.3 hypothetical protein 625652 930602 SP_0653 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345158.1 625398 D 170187 CDS NP_345159.1 15900555 930603 625627..625728 1 NC_003028.3 hypothetical protein 625728 930603 SP_0654 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345159.1 625627 D 170187 CDS NP_345160.2 118090028 930604 625664..627718 1 NC_003028.3 identified by match to PFAM protein family HMM PF00999; sodium/hydrogen exchanger family protein 627718 930604 SP_0655 Streptococcus pneumoniae TIGR4 sodium/hydrogen exchanger family protein NP_345160.2 625664 D 170187 CDS NP_345162.1 15900558 930606 627897..628757 1 NC_003028.3 ribonuclease BN 628757 930606 SP_0657 Streptococcus pneumoniae TIGR4 ribonuclease BN NP_345162.1 627897 D 170187 CDS NP_345163.1 15900559 930607 628968..629678 1 NC_003028.3 similar to GP:6714962; identified by sequence similarity; cytochrome c-type biogenesis protein CcdA 629678 930607 SP_0658 Streptococcus pneumoniae TIGR4 cytochrome c-type biogenesis protein CcdA NP_345163.1 628968 D 170187 CDS NP_345164.1 15900560 930608 629698..630264 1 NC_003028.3 thioredoxin 630264 930608 SP_0659 Streptococcus pneumoniae TIGR4 thioredoxin NP_345164.1 629698 D 170187 CDS NP_345165.1 15900561 930609 630452..631387 1 NC_003028.3 this fusion consists of methionine sulfoxide A reductase at the N-terminus and B at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion; bifunctional methionine sulfoxide reductase A/B 631387 930609 SP_0660 Streptococcus pneumoniae TIGR4 bifunctional methionine sulfoxide reductase A/B NP_345165.1 630452 D 170187 CDS NP_345166.1 15900562 930610 631655..632392 1 NC_003028.3 DNA-binding response regulator 632392 930610 SP_0661 Streptococcus pneumoniae TIGR4 DNA-binding response regulator NP_345166.1 631655 D 170187 CDS NP_345167.1 15900563 930611 632389..634080 1 NC_003028.3 sensor histidine kinase 634080 930611 SP_0662 Streptococcus pneumoniae TIGR4 sensor histidine kinase NP_345167.1 632389 D 170187 CDS NP_345168.1 15900564 930612 634196..634759 1 NC_003028.3 hypothetical protein 634759 930612 SP_0663 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345168.1 634196 D 170187 CDS NP_345169.1 15900565 930613 634856..640501 1 NC_003028.3 identified by match to PFAM protein family HMM PF00746; zinc metalloprotease ZmpB 640501 930613 SP_0664 Streptococcus pneumoniae TIGR4 zinc metalloprotease ZmpB NP_345169.1 634856 D 170187 CDS NP_345170.1 15900566 930614 640562..642283 1 NC_003028.3 identified by match to PFAM protein family HMM PF00425; chorismate binding protein 642283 930614 SP_0665 Streptococcus pneumoniae TIGR4 chorismate binding protein NP_345170.1 640562 D 170187 CDS NP_345171.1 15900567 930615 642284..642901 1 NC_003028.3 hypothetical protein 642901 930615 SP_0666 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345171.1 642284 D 170187 CDS NP_345172.1 15900568 930616 642951..643949 1 NC_003028.3 surface protein 643949 930616 SP_0667 Streptococcus pneumoniae TIGR4 surface protein NP_345172.1 642951 D 170187 CDS NP_345173.2 194172858 930617 644073..645035 1 NC_003028.3 glucokinase 645035 930617 SP_0668 Streptococcus pneumoniae TIGR4 glucokinase NP_345173.2 644073 D 170187 CDS NP_345174.1 15900570 930618 645132..645971 1 NC_003028.3 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 645971 thyA 930618 thyA Streptococcus pneumoniae TIGR4 thymidylate synthase NP_345174.1 645132 D 170187 CDS NP_345175.1 15900571 930619 complement(646019..646189) 1 NC_003028.3 hypothetical protein 646189 930619 SP_0670 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345175.1 646019 R 170187 CDS NP_345176.1 15900572 930620 646310..647194 1 NC_003028.3 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 647194 miaA 930620 miaA Streptococcus pneumoniae TIGR4 tRNA delta(2)-isopentenylpyrophosphate transferase NP_345176.1 646310 D 170187 CDS NP_345177.1 15900573 930621 647187..648425 1 NC_003028.3 GTP-binding protein HflX 648425 930621 SP_0672 Streptococcus pneumoniae TIGR4 GTP-binding protein HflX NP_345177.1 647187 D 170187 CDS NP_345178.1 15900574 930622 648418..649041 1 NC_003028.3 hypothetical protein 649041 930622 SP_0673 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345178.1 648418 D 170187 CDS NP_345179.1 15900575 930623 649056..649985 1 NC_003028.3 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 649985 930623 SP_0674 Streptococcus pneumoniae TIGR4 ribonuclease Z NP_345179.1 649056 D 170187 CDS NP_345180.1 15900576 930624 650006..650761 1 NC_003028.3 short chain dehydrogenase/reductase family oxidoreductase 650761 930624 SP_0675 Streptococcus pneumoniae TIGR4 short chain dehydrogenase/reductase family oxidoreductase NP_345180.1 650006 D 170187 CDS NP_345181.1 15900577 930625 complement(650815..651783) 1 NC_003028.3 transcriptional regulator 651783 930625 SP_0676 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_345181.1 650815 R 170187 CDS NP_345182.1 15900578 930626 651835..652056 1 NC_003028.3 hypothetical protein 652056 930626 SP_0677 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345182.1 651835 D 170187 CDS NP_345183.1 15900579 930627 652056..652436 1 NC_003028.3 hypothetical protein 652436 930627 SP_0678 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345183.1 652056 D 170187 CDS NP_345184.1 15900580 930628 652555..652752 1 NC_003028.3 hypothetical protein 652752 930628 SP_0679 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345184.1 652555 D 170187 CDS NP_345185.1 15900581 930629 complement(652792..653517) 1 NC_003028.3 ribosomal small subunit pseudouridine synthase A 653517 930629 SP_0680 Streptococcus pneumoniae TIGR4 ribosomal small subunit pseudouridine synthase A NP_345185.1 652792 R 170187 CDS NP_345186.1 15900582 930630 653679..655520 1 NC_003028.3 elongation factor Tu family protein 655520 930630 SP_0681 Streptococcus pneumoniae TIGR4 elongation factor Tu family protein NP_345186.1 653679 D 170187 CDS NP_345187.1 15900583 930631 655540..655794 1 NC_003028.3 hypothetical protein 655794 930631 SP_0682 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345187.1 655540 D 170187 CDS NP_345188.1 15900584 930632 complement(655988..656086) 1 NC_003028.3 hypothetical protein 656086 930632 SP_0683 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345188.1 655988 R 170187 CDS NP_345189.1 15900585 930633 656249..656344 1 NC_003028.3 hypothetical protein 656344 930633 SP_0684 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345189.1 656249 D 170187 CDS NP_345190.1 15900586 930634 656341..656433 1 NC_003028.3 hypothetical protein 656433 930634 SP_0685 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345190.1 656341 D 170187 CDS NP_345191.1 15900587 930636 656527..658548 1 NC_003028.3 hypothetical protein 658548 930636 SP_0686 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345191.1 656527 D 170187 CDS NP_345192.1 15900588 930637 658550..659191 1 NC_003028.3 ABC transporter ATP-binding protein 659191 930637 SP_0687 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345192.1 658550 D 170187 CDS NP_345193.1 15900589 930638 659295..660647 1 NC_003028.3 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 660647 murD 930638 murD Streptococcus pneumoniae TIGR4 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase NP_345193.1 659295 D 170187 CDS NP_345194.1 15900590 930639 660649..661707 1 NC_003028.3 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 661707 murG 930639 murG Streptococcus pneumoniae TIGR4 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase NP_345194.1 660649 D 170187 CDS NP_345195.1 15900591 930640 661717..662916 1 NC_003028.3 similar to GP:4009482; identified by sequence similarity; cell division protein DivIB 662916 930640 SP_0690 Streptococcus pneumoniae TIGR4 cell division protein DivIB NP_345195.1 661717 D 170187 CDS NP_345196.1 15900592 930641 663026..663172 1 NC_003028.3 hypothetical protein 663172 930641 SP_0691 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345196.1 663026 D 170187 CDS NP_345197.1 15900593 930642 663184..663315 1 NC_003028.3 hypothetical protein 663315 930642 SP_0692 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345197.1 663184 D 170187 CDS NP_345198.1 15900594 930643 663498..663614 1 NC_003028.3 hypothetical protein 663614 930643 SP_0693 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345198.1 663498 D 170187 CDS NP_345199.1 15900595 930644 663748..664311 1 NC_003028.3 hypothetical protein 664311 930644 SP_0694 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345199.1 663748 D 170187 CDS NP_345200.1 15900596 930645 664654..665289 1 NC_003028.3 identified by match to PFAM protein family HMM PF00899; HesA/MoeB/ThiF family protein 665289 930645 SP_0695 Streptococcus pneumoniae TIGR4 HesA/MoeB/ThiF family protein NP_345200.1 664654 D 170187 CDS NP_345201.1 15900597 930646 665286..665666 1 NC_003028.3 hypothetical protein 665666 930646 SP_0696 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345201.1 665286 D 170187 CDS NP_345202.1 15900598 930648 666702..667415 1 NC_003028.3 hypothetical protein 667415 930648 SP_0698 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345202.1 666702 D 170187 CDS NP_345203.1 15900599 930649 667416..667514 1 NC_003028.3 hypothetical protein 667514 930649 SP_0699 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345203.1 667416 D 170187 CDS NP_345204.1 15900600 930651 668161..668862 1 NC_003028.3 OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 668862 930651 SP_0701 Streptococcus pneumoniae TIGR4 orotidine 5'-phosphate decarboxylase NP_345204.1 668161 D 170187 CDS NP_345205.1 15900601 930652 668896..669528 1 NC_003028.3 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 669528 pyrE 930652 pyrE Streptococcus pneumoniae TIGR4 orotate phosphoribosyltransferase NP_345205.1 668896 D 170187 CDS NP_345206.1 15900602 930653 669761..670111 1 NC_003028.3 hypothetical protein 670111 930653 SP_0703 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345206.1 669761 D 170187 CDS NP_345207.1 15900603 930654 670207..670971 1 NC_003028.3 hypothetical protein 670971 930654 SP_0704 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345207.1 670207 D 170187 CDS NP_345208.1 15900604 930655 670920..671723 1 NC_003028.3 hypothetical protein 671723 930655 SP_0705 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345208.1 670920 D 170187 CDS NP_345209.1 15900605 930656 671727..672431 1 NC_003028.3 hypothetical protein 672431 930656 SP_0706 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345209.1 671727 D 170187 CDS NP_345210.1 15900606 930657 672428..673075 1 NC_003028.3 ABC transporter ATP-binding protein 673075 930657 SP_0707 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345210.1 672428 D 170187 CDS NP_345211.1 15900607 930659 complement(674045..674803) 1 NC_003028.3 amino acid ABC transporter ATP-binding protein 674803 930659 SP_0709 Streptococcus pneumoniae TIGR4 amino acid ABC transporter ATP-binding protein NP_345211.1 674045 R 170187 CDS NP_345212.1 15900608 930660 complement(674804..675481) 1 NC_003028.3 amino acid ABC transporter permease 675481 930660 SP_0710 Streptococcus pneumoniae TIGR4 amino acid ABC transporter permease NP_345212.1 674804 R 170187 CDS NP_345213.1 15900609 930661 complement(675441..676061) 1 NC_003028.3 amino acid ABC transporter permease 676061 930661 SP_0711 Streptococcus pneumoniae TIGR4 amino acid ABC transporter permease NP_345213.1 675441 R 170187 CDS NP_345214.3 255964979 930663 676624..678099 1 NC_003028.3 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 678099 lysS 930663 lysS Streptococcus pneumoniae TIGR4 lysyl-tRNA synthetase NP_345214.3 676624 D 170187 CDS NP_345215.1 15900611 930664 complement(678711..680057) 1 NC_003028.3 similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 680057 930664 SP_0714 Streptococcus pneumoniae TIGR4 IS1380-Spn1 transposase NP_345215.1 678711 R 170187 CDS NP_345216.1 15900612 930665 680430..681566 1 NC_003028.3 identified by match to PFAM protein family HMM PF01070; lactate oxidase 681566 930665 SP_0715 Streptococcus pneumoniae TIGR4 lactate oxidase NP_345216.1 680430 D 170187 CDS NP_345217.1 15900613 930666 682123..682791 1 NC_003028.3 similar to GB:X59720 SP:P25362 PID:1907163; identified by sequence similarity; transcriptional regulator 682791 930666 SP_0716 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_345217.1 682123 D 170187 CDS NP_345218.1 15900614 930667 683028..683810 1 NC_003028.3 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 683810 930667 SP_0717 Streptococcus pneumoniae TIGR4 hydroxyethylthiazole kinase NP_345218.1 683028 D 170187 CDS NP_345219.1 15900615 930668 683812..684441 1 NC_003028.3 thiamine-phosphate pyrophosphorylase 684441 930668 SP_0718 Streptococcus pneumoniae TIGR4 thiamine-phosphate pyrophosphorylase NP_345219.1 683812 D 170187 CDS NP_345220.1 15900616 930669 685000..685560 1 NC_003028.3 hypothetical protein 685560 930669 SP_0719 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345220.1 685000 D 170187 CDS NP_345221.1 15900617 930670 685561..686946 1 NC_003028.3 ABC transporter ATP-binding protein 686946 930670 SP_0720 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345221.1 685561 D 170187 CDS NP_345222.1 15900618 930671 686948..687598 1 NC_003028.3 hypothetical protein 687598 930671 SP_0721 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345222.1 686948 D 170187 CDS NP_345223.1 15900619 930672 687609..688301 1 NC_003028.3 similar to GB:M73546 SP:P25052 PID:143729 GB:AL009126; identified by sequence similarity; transcriptional activator TenA 688301 930672 SP_0722 Streptococcus pneumoniae TIGR4 transcriptional activator TenA NP_345223.1 687609 D 170187 CDS NP_345224.1 15900620 930673 688306..688830 1 NC_003028.3 similar to GB:NC_000854; identified by sequence similarity; hypothetical protein 688830 930673 SP_0723 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345224.1 688306 D 170187 CDS NP_345225.1 15900621 930674 688830..689633 1 NC_003028.3 hydroxyethylthiazole kinase 689633 930674 SP_0724 Streptococcus pneumoniae TIGR4 hydroxyethylthiazole kinase NP_345225.1 688830 D 170187 CDS NP_345226.1 15900622 930675 689626..690258 1 NC_003028.3 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 690258 thiE 930675 thiE Streptococcus pneumoniae TIGR4 thiamine-phosphate pyrophosphorylase NP_345226.1 689626 D 170187 CDS NP_345227.1 15900623 930676 complement(690468..691259) 1 NC_003028.3 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 691259 930676 SP_0726 Streptococcus pneumoniae TIGR4 phosphomethylpyrimidine kinase NP_345227.1 690468 R 170187 CDS NP_345228.1 15900624 930677 691619..692020 1 NC_003028.3 transcriptional repressor 692020 930677 SP_0727 Streptococcus pneumoniae TIGR4 transcriptional repressor NP_345228.1 691619 D 170187 CDS NP_345229.1 15900625 930678 692031..692402 1 NC_003028.3 hypothetical protein 692402 930678 SP_0728 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345229.1 692031 D 170187 CDS NP_345230.1 15900626 930679 692673..694655 1 NC_003028.3 cation transporter E1-E2 family ATPase 694655 930679 SP_0729 Streptococcus pneumoniae TIGR4 cation transporter E1-E2 family ATPase NP_345230.1 692673 D 170187 CDS NP_345231.1 15900627 930680 694862..696637 1 NC_003028.3 pyruvate oxidase 696637 930680 SP_0730 Streptococcus pneumoniae TIGR4 pyruvate oxidase NP_345231.1 694862 D 170187 CDS NP_345232.1 15900628 930681 696748..697095 1 NC_003028.3 similar to GP:7981392; identified by sequence similarity; hypothetical protein 697095 930681 SP_0731 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345232.1 696748 D 170187 CDS NP_345233.1 15900629 930683 complement(697742..698008) 1 NC_003028.3 hypothetical protein 698008 930683 SP_0733 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345233.1 697742 R 170187 CDS NP_345234.1 15900630 930684 complement(698363..698458) 1 NC_003028.3 hypothetical protein 698458 930684 SP_0734 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345234.1 698363 R 170187 CDS NP_345235.1 15900631 930686 698940..699884 1 NC_003028.3 identified by match to PFAM protein family HMM PF01238; mannose-6-phosphate isomerase 699884 930686 SP_0736 Streptococcus pneumoniae TIGR4 mannose-6-phosphate isomerase NP_345235.1 698940 D 170187 CDS NP_345236.1 15900632 930687 complement(699905..701176) 1 NC_003028.3 sodium-dependent transporter 701176 930687 SP_0737 Streptococcus pneumoniae TIGR4 sodium-dependent transporter NP_345236.1 699905 R 170187 CDS NP_345237.1 15900633 930688 complement(701173..701400) 1 NC_003028.3 hypothetical protein 701400 930688 SP_0738 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345237.1 701173 R 170187 CDS NP_345238.1 15900634 930689 701499..702239 1 NC_003028.3 MerR family transcriptional regulator 702239 930689 SP_0739 Streptococcus pneumoniae TIGR4 MerR family transcriptional regulator NP_345238.1 701499 D 170187 CDS NP_345239.1 15900635 930690 complement(702268..702723) 1 NC_003028.3 MutT/nudix family protein 702723 930690 SP_0740 Streptococcus pneumoniae TIGR4 MutT/nudix family protein NP_345239.1 702268 R 170187 CDS NP_345240.1 15900636 930691 complement(702743..703918) 1 NC_003028.3 hypothetical protein 703918 930691 SP_0741 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345240.1 702743 R 170187 CDS NP_345241.1 15900637 930692 complement(703977..704822) 1 NC_003028.3 hypothetical protein 704822 930692 SP_0742 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345241.1 703977 R 170187 CDS NP_345242.1 15900638 930693 704947..705504 1 NC_003028.3 TetR family transcriptional regulator 705504 930693 SP_0743 Streptococcus pneumoniae TIGR4 TetR family transcriptional regulator NP_345242.1 704947 D 170187 CDS NP_345243.1 15900639 930694 705523..705990 1 NC_003028.3 cytidine and deoxycytidylate deaminase 705990 930694 SP_0744 Streptococcus pneumoniae TIGR4 cytidine and deoxycytidylate deaminase NP_345243.1 705523 D 170187 CDS NP_345244.1 15900640 930695 706079..706708 1 NC_003028.3 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 706708 upp 930695 upp Streptococcus pneumoniae TIGR4 uracil phosphoribosyltransferase NP_345244.1 706079 D 170187 CDS NP_345245.1 15900641 930696 706882..707472 1 NC_003028.3 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 707472 clpP 930696 clpP Streptococcus pneumoniae TIGR4 ATP-dependent Clp protease proteolytic subunit NP_345245.1 706882 D 170187 CDS NP_345246.1 15900642 930697 complement(707469..707567) 1 NC_003028.3 hypothetical protein 707567 930697 SP_0747 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345246.1 707469 R 170187 CDS NP_345247.1 15900643 930698 707551..707799 1 NC_003028.3 hypothetical protein 707799 930698 SP_0748 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345247.1 707551 D 170187 CDS NP_345248.1 15900644 930699 707900..709060 1 NC_003028.3 branched-chain amino acid ABC transporter substrate-binding protein 709060 930699 SP_0749 Streptococcus pneumoniae TIGR4 branched-chain amino acid ABC transporter substrate-binding protein NP_345248.1 707900 D 170187 CDS NP_345249.1 15900645 930700 709328..710197 1 NC_003028.3 branched-chain amino acid ABC transporter permease 710197 930700 SP_0750 Streptococcus pneumoniae TIGR4 branched-chain amino acid ABC transporter permease NP_345249.1 709328 D 170187 CDS NP_345250.1 15900646 930701 710201..711157 1 NC_003028.3 branched-chain amino acid ABC transporter permease 711157 930701 SP_0751 Streptococcus pneumoniae TIGR4 branched-chain amino acid ABC transporter permease NP_345250.1 710201 D 170187 CDS NP_345251.1 15900647 930702 711157..711921 1 NC_003028.3 branched-chain amino acid ABC transporter ATP-binding protein 711921 930702 SP_0752 Streptococcus pneumoniae TIGR4 branched-chain amino acid ABC transporter ATP-binding protein NP_345251.1 711157 D 170187 CDS NP_345252.1 15900648 930703 711921..712631 1 NC_003028.3 branched-chain amino acid ABC transporter ATP-binding protein 712631 930703 SP_0753 Streptococcus pneumoniae TIGR4 branched-chain amino acid ABC transporter ATP-binding protein NP_345252.1 711921 D 170187 CDS NP_345253.1 15900649 930704 712939..713595 1 NC_003028.3 acetoin utilization protein AcuB 713595 930704 SP_0754 Streptococcus pneumoniae TIGR4 acetoin utilization protein AcuB NP_345253.1 712939 D 170187 CDS YP_873927.1 118090032 930705 join(713703..713774,713776..714798) 1 NC_003028.3 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 714798 prfB 930705 prfB Streptococcus pneumoniae TIGR4 peptide chain release factor 2 YP_873927.1 713703 D 170187 CDS NP_345254.1 15900650 930706 714816..715508 1 NC_003028.3 cell division ABC transporter ATP-binding protein FtsE 715508 930706 SP_0756 Streptococcus pneumoniae TIGR4 cell division ABC transporter ATP-binding protein FtsE NP_345254.1 714816 D 170187 CDS NP_345255.1 15900651 930707 715501..716427 1 NC_003028.3 cell division ABC transporter permease FtsX 716427 930707 SP_0757 Streptococcus pneumoniae TIGR4 cell division ABC transporter permease FtsX NP_345255.1 715501 D 170187 CDS NP_345256.1 15900652 930708 716713..718893 1 NC_003028.3 PTS system transporter subunit IIABC 718893 930708 SP_0758 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIABC NP_345256.1 716713 D 170187 CDS NP_345257.1 15900653 930709 718899..719018 1 NC_003028.3 hypothetical protein 719018 930709 SP_0759 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345257.1 718899 D 170187 CDS NP_345258.1 15900654 930710 719074..719760 1 NC_003028.3 hypothetical protein 719760 930710 SP_0760 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345258.1 719074 D 170187 CDS NP_345259.1 15900655 930711 719900..721243 1 NC_003028.3 DEAD/DEAH box helicase 721243 930711 SP_0761 Streptococcus pneumoniae TIGR4 DEAD/DEAH box helicase NP_345259.1 719900 D 170187 CDS NP_345260.1 15900656 930712 721458..722648 1 NC_003028.3 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 722648 930712 SP_0762 Streptococcus pneumoniae TIGR4 S-adenosylmethionine synthetase NP_345260.1 721458 D 170187 CDS NP_345261.1 15900657 930713 722939..723067 1 NC_003028.3 hypothetical protein 723067 930713 SP_0763 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345261.1 722939 D 170187 CDS NP_345262.1 15900658 930714 723201..724136 1 NC_003028.3 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 724136 930714 SP_0764 Streptococcus pneumoniae TIGR4 dihydroorotate dehydrogenase 1A NP_345262.1 723201 D 170187 CDS NP_345263.1 15900659 930715 724170..725207 1 NC_003028.3 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 725207 holA 930715 holA Streptococcus pneumoniae TIGR4 DNA polymerase III subunit delta NP_345263.1 724170 D 170187 CDS NP_345264.1 15900660 930716 725380..725985 1 NC_003028.3 superoxide dismutase, manganese-dependent 725985 930716 SP_0766 Streptococcus pneumoniae TIGR4 superoxide dismutase, manganese-dependent NP_345264.1 725380 D 170187 CDS NP_345265.1 15900661 930717 726141..726653 1 NC_003028.3 hypothetical protein 726653 930717 SP_0767 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345265.1 726141 D 170187 CDS NP_345266.1 15900662 930718 726674..727759 1 NC_003028.3 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 727759 930718 SP_0768 Streptococcus pneumoniae TIGR4 ribosomal RNA large subunit methyltransferase N NP_345266.1 726674 D 170187 CDS NP_345267.1 15900663 930719 727762..728241 1 NC_003028.3 similar to GP:7110140; identified by sequence similarity; VanZF-related protein 728241 930719 SP_0769 Streptococcus pneumoniae TIGR4 VanZF-related protein NP_345267.1 727762 D 170187 CDS NP_345268.1 15900664 930720 728243..729784 1 NC_003028.3 ABC transporter ATP-binding protein 729784 930720 SP_0770 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345268.1 728243 D 170187 CDS NP_345269.1 15900665 930721 complement(729840..730643) 1 NC_003028.3 cyclophilin type peptidyl-prolyl cis-trans isomerase 730643 930721 SP_0771 Streptococcus pneumoniae TIGR4 cyclophilin type peptidyl-prolyl cis-trans isomerase NP_345269.1 729840 R 170187 CDS NP_345270.1 15900666 930722 complement(730727..730930) 1 NC_003028.3 hypothetical protein 730930 930722 SP_0772 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345270.1 730727 R 170187 CDS NP_345271.1 15900667 930723 731337..731435 1 NC_003028.3 hypothetical protein 731435 930723 SP_0773 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345271.1 731337 D 170187 CDS NP_345272.1 15900668 930724 complement(731419..731628) 1 NC_003028.3 hypothetical protein 731628 930724 SP_0774 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345272.1 731419 R 170187 CDS NP_345273.1 15900669 930725 731798..732070 1 NC_003028.3 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 732070 rpsP 930725 rpsP Streptococcus pneumoniae TIGR4 30S ribosomal protein S16 NP_345273.1 731798 D 170187 CDS NP_345274.1 15900670 930726 732090..732329 1 NC_003028.3 KH domain-containing protein 732329 930726 SP_0776 Streptococcus pneumoniae TIGR4 KH domain-containing protein NP_345274.1 732090 D 170187 CDS NP_345275.1 15900671 930727 732894..733694 1 NC_003028.3 hypothetical protein 733694 930727 SP_0777 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345275.1 732894 D 170187 CDS NP_345276.1 15900672 930728 733725..734243 1 NC_003028.3 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 734243 rimM 930728 rimM Streptococcus pneumoniae TIGR4 16S rRNA-processing protein RimM NP_345276.1 733725 D 170187 CDS NP_345277.1 15900673 930729 734233..734952 1 NC_003028.3 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 734952 trmD 930729 trmD Streptococcus pneumoniae TIGR4 tRNA (guanine-N(1)-)-methyltransferase NP_345277.1 734233 D 170187 CDS YP_873928.1 118090036 930730 734964..735302 1 NC_003028.3 ATP cone domain-containing protein 735302 930730 SP_0780 Streptococcus pneumoniae TIGR4 ATP cone domain-containing protein YP_873928.1 734964 D 170187 CDS NP_345278.1 15900674 930731 complement(735333..735653) 1 NC_003028.3 hypothetical protein 735653 930731 SP_0781 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345278.1 735333 R 170187 CDS NP_345279.1 15900675 930732 735727..735966 1 NC_003028.3 hypothetical protein 735966 930732 SP_0782 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345279.1 735727 D 170187 CDS NP_345280.1 15900676 930733 complement(736172..736708) 1 NC_003028.3 hypothetical protein 736708 930733 SP_0783 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345280.1 736172 R 170187 CDS NP_345281.1 15900677 930734 complement(736905..738251) 1 NC_003028.3 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 738251 930734 SP_0784 Streptococcus pneumoniae TIGR4 glutathione reductase NP_345281.1 736905 R 170187 CDS NP_345282.1 15900678 930735 738516..739715 1 NC_003028.3 hypothetical protein 739715 930735 SP_0785 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345282.1 738516 D 170187 CDS NP_345283.1 15900679 930736 739699..740400 1 NC_003028.3 ABC transporter ATP-binding protein 740400 930736 SP_0786 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345283.1 739699 D 170187 CDS NP_345284.1 15900680 930737 740402..741661 1 NC_003028.3 hypothetical protein 741661 930737 SP_0787 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345284.1 740402 D 170187 CDS NP_345285.1 15900681 930738 741785..743782 1 NC_003028.3 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 743782 metG 930738 metG Streptococcus pneumoniae TIGR4 methionyl-tRNA synthetase NP_345285.1 741785 D 170187 CDS NP_345286.1 15900682 930739 744248..744568 1 NC_003028.3 hypothetical protein 744568 930739 SP_0789 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345286.1 744248 D 170187 CDS NP_345287.1 15900683 930740 744572..745387 1 NC_003028.3 hypothetical protein 745387 930740 SP_0790 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345287.1 744572 D 170187 CDS NP_345288.1 15900684 930741 745462..746388 1 NC_003028.3 aldo/keto reductase 746388 930741 SP_0791 Streptococcus pneumoniae TIGR4 aldo/keto reductase NP_345288.1 745462 D 170187 CDS NP_345289.1 15900685 930742 746454..746720 1 NC_003028.3 hypothetical protein 746720 930742 SP_0792 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345289.1 746454 D 170187 CDS NP_345290.1 15900686 930743 746713..747411 1 NC_003028.3 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 747411 fabG 930743 fabG Streptococcus pneumoniae TIGR4 3-ketoacyl-ACP reductase NP_345290.1 746713 D 170187 CDS NP_345291.1 15900687 930744 747422..747922 1 NC_003028.3 MutT/nudix family protein 747922 930744 SP_0794 Streptococcus pneumoniae TIGR4 MutT/nudix family protein NP_345291.1 747422 D 170187 CDS NP_345292.1 15900688 930745 747975..748769 1 NC_003028.3 hypothetical protein 748769 930745 SP_0795 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345292.1 747975 D 170187 CDS NP_345293.1 15900689 930746 748744..749184 1 NC_003028.3 hypothetical protein 749184 930746 SP_0796 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345293.1 748744 D 170187 CDS NP_345294.1 15900690 930747 749307..751853 1 NC_003028.3 identified by match to PFAM protein family HMM PF01433; aminopeptidase 751853 930747 SP_0797 Streptococcus pneumoniae TIGR4 aminopeptidase NP_345294.1 749307 D 170187 CDS NP_345295.1 15900691 930748 751962..752636 1 NC_003028.3 DNA-binding response regulator CiaR 752636 930748 SP_0798 Streptococcus pneumoniae TIGR4 DNA-binding response regulator CiaR NP_345295.1 751962 D 170187 CDS NP_345296.1 15900692 930749 752626..753960 1 NC_003028.3 sensor histidine kinase CiaH 753960 930749 SP_0799 Streptococcus pneumoniae TIGR4 sensor histidine kinase CiaH NP_345296.1 752626 D 170187 CDS NP_345297.1 15900693 930750 complement(753994..754281) 1 NC_003028.3 hypothetical protein 754281 930750 SP_0800 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345297.1 753994 R 170187 CDS NP_345298.1 15900694 930751 754280..755350 1 NC_003028.3 hypothetical protein 755350 930751 SP_0801 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345298.1 754280 D 170187 CDS NP_345299.1 15900695 930752 755550..758000 1 NC_003028.3 unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 758000 930752 SP_0802 Streptococcus pneumoniae TIGR4 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon NP_345299.1 755550 D 170187 CDS NP_345300.1 15900696 930753 758037..759260 1 NC_003028.3 rod shape-determining protein RodA 759260 930753 SP_0803 Streptococcus pneumoniae TIGR4 rod shape-determining protein RodA NP_345300.1 758037 D 170187 CDS NP_345301.1 15900697 930754 759271..759825 1 NC_003028.3 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein 759825 930754 SP_0804 Streptococcus pneumoniae TIGR4 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein NP_345301.1 759271 D 170187 CDS NP_345302.1 15900698 930755 759901..760473 1 NC_003028.3 identified by match to PFAM protein family HMM PF00702; HAD superfamily hydrolase 760473 930755 SP_0805 Streptococcus pneumoniae TIGR4 HAD superfamily hydrolase NP_345302.1 759901 D 170187 CDS NP_345303.1 15900699 930756 760488..762434 1 NC_003028.3 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 762434 gyrB 930756 gyrB Streptococcus pneumoniae TIGR4 DNA gyrase subunit B NP_345303.1 760488 D 170187 CDS NP_345304.1 15900700 930757 762516..764243 1 NC_003028.3 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 764243 930757 SP_0807 Streptococcus pneumoniae TIGR4 septation ring formation regulator EzrA NP_345304.1 762516 D 170187 CDS NP_345305.1 15900701 930759 764779..764874 1 NC_003028.3 hypothetical protein 764874 930759 SP_0809 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345305.1 764779 D 170187 CDS NP_345306.1 15900702 930760 765229..765495 1 NC_003028.3 hypothetical protein 765495 930760 SP_0810 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345306.1 765229 D 170187 CDS NP_345307.1 15900703 930761 765527..766036 1 NC_003028.3 transposase 766036 930761 SP_0811 Streptococcus pneumoniae TIGR4 transposase NP_345307.1 765527 D 170187 CDS NP_345308.1 15900704 930765 768130..768243 1 NC_003028.3 hypothetical protein 768243 930765 SP_0815 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345308.1 768130 D 170187 CDS NP_345309.1 15900705 930766 complement(768201..768500) 1 NC_003028.3 hypothetical protein 768500 930766 SP_0816 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345309.1 768201 R 170187 CDS NP_345310.1 15900706 930767 complement(768665..769087) 1 NC_003028.3 MutT/nudix family protein 769087 930767 SP_0817 Streptococcus pneumoniae TIGR4 MutT/nudix family protein NP_345310.1 768665 R 170187 CDS YP_873929.1 118090043 930768 769180..769530 1 NC_003028.3 Orf1; IS630-Spn1 transposase 769530 930768 SP_0818 Streptococcus pneumoniae TIGR4 IS630-Spn1 transposase YP_873929.1 769180 D 170187 CDS NP_345311.1 15900707 930769 769728..770051 1 NC_003028.3 IS630-Spn1, transposase Orf2 770051 930769 SP_0819 Streptococcus pneumoniae TIGR4 IS630-Spn1, transposase Orf2 NP_345311.1 769728 D 170187 CDS NP_345312.1 15900708 930770 complement(770258..772516) 1 NC_003028.3 identified by match to PFAM protein family HMM PF02151; ATP-dependent Clp protease ATP-binding subunit ClpE 772516 930770 SP_0820 Streptococcus pneumoniae TIGR4 ATP-dependent Clp protease ATP-binding subunit ClpE NP_345312.1 770258 R 170187 CDS NP_345313.1 15900709 930771 772647..772748 1 NC_003028.3 hypothetical protein 772748 930771 SP_0821 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345313.1 772647 D 170187 CDS NP_345314.1 15900710 930772 complement(772745..772975) 1 NC_003028.3 hypothetical protein 772975 930772 SP_0822 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345314.1 772745 R 170187 CDS NP_345315.1 15900711 930773 773159..773848 1 NC_003028.3 amino acid ABC transporter permease 773848 930773 SP_0823 Streptococcus pneumoniae TIGR4 amino acid ABC transporter permease NP_345315.1 773159 D 170187 CDS NP_345316.1 15900712 930774 773848..774582 1 NC_003028.3 amino acid ABC transporter ATP-binding protein 774582 930774 SP_0824 Streptococcus pneumoniae TIGR4 amino acid ABC transporter ATP-binding protein NP_345316.1 773848 D 170187 CDS NP_345317.1 15900713 930775 774761..775618 1 NC_003028.3 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 775618 930775 SP_0825 Streptococcus pneumoniae TIGR4 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase NP_345317.1 774761 D 170187 CDS NP_345318.1 15900714 930776 775756..776577 1 NC_003028.3 hypothetical protein 776577 930776 SP_0826 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345318.1 775756 D 170187 CDS NP_345319.1 15900715 930778 777729..778412 1 NC_003028.3 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 778412 930778 SP_0828 Streptococcus pneumoniae TIGR4 ribose-5-phosphate isomerase A NP_345319.1 777729 D 170187 CDS NP_345320.1 15900716 930779 778426..779637 1 NC_003028.3 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 779637 930779 SP_0829 Streptococcus pneumoniae TIGR4 phosphopentomutase NP_345320.1 778426 D 170187 CDS NP_345321.1 15900717 930780 779639..780181 1 NC_003028.3 hypothetical protein 780181 930780 SP_0830 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345321.1 779639 D 170187 CDS NP_345322.1 15900718 930781 780197..781006 1 NC_003028.3 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 781006 930781 SP_0831 Streptococcus pneumoniae TIGR4 purine nucleoside phosphorylase NP_345322.1 780197 D 170187 CDS NP_345323.1 15900719 930782 781470..781640 1 NC_003028.3 hypothetical protein 781640 930782 SP_0832 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345323.1 781470 D 170187 CDS NP_345324.1 15900720 930783 781707..782462 1 NC_003028.3 hypothetical protein 782462 930783 SP_0833 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345324.1 781707 D 170187 CDS NP_345325.1 15900721 930784 782487..782999 1 NC_003028.3 similar to GP:3309561; identified by sequence similarity; hemolysin-like protein 782999 930784 SP_0834 Streptococcus pneumoniae TIGR4 hemolysin-like protein NP_345325.1 782487 D 170187 CDS NP_345326.1 15900722 930785 783653..784363 1 NC_003028.3 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 784363 deoD 930785 deoD Streptococcus pneumoniae TIGR4 purine nucleoside phosphorylase NP_345326.1 783653 D 170187 CDS NP_345327.1 15900723 930786 complement(784413..785669) 1 NC_003028.3 IS1167, transposase 785669 930786 SP_0836 Streptococcus pneumoniae TIGR4 IS1167, transposase NP_345327.1 784413 R 170187 CDS NP_345328.1 15900724 930787 complement(785809..786333) 1 NC_003028.3 topology modulation protein 786333 930787 SP_0837 Streptococcus pneumoniae TIGR4 topology modulation protein NP_345328.1 785809 R 170187 CDS NP_345329.1 15900725 930788 complement(786386..786622) 1 NC_003028.3 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 786622 rpsT 930788 rpsT Streptococcus pneumoniae TIGR4 30S ribosomal protein S20 NP_345329.1 786386 R 170187 CDS NP_345330.1 15900726 930789 complement(786690..787610) 1 NC_003028.3 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 787610 930789 SP_0839 Streptococcus pneumoniae TIGR4 pantothenate kinase NP_345330.1 786690 R 170187 CDS NP_345331.1 15900727 930790 787800..788036 1 NC_003028.3 hypothetical protein 788036 930790 SP_0840 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345331.1 787800 D 170187 CDS NP_345332.1 15900728 930791 788410..789000 1 NC_003028.3 hypothetical protein 789000 930791 SP_0841 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345332.1 788410 D 170187 CDS NP_345333.1 15900729 930792 788997..790274 1 NC_003028.3 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 790274 930792 SP_0842 Streptococcus pneumoniae TIGR4 pyrimidine-nucleoside phosphorylase NP_345333.1 788997 D 170187 CDS NP_345334.1 15900730 930793 790292..790954 1 NC_003028.3 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 790954 930793 SP_0843 Streptococcus pneumoniae TIGR4 deoxyribose-phosphate aldolase NP_345334.1 790292 D 170187 CDS NP_345335.1 15900731 930794 790941..791330 1 NC_003028.3 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 791330 930794 SP_0844 Streptococcus pneumoniae TIGR4 cytidine deaminase NP_345335.1 790941 D 170187 CDS NP_345336.1 15900732 930795 791420..792472 1 NC_003028.3 lipoprotein 792472 930795 SP_0845 Streptococcus pneumoniae TIGR4 lipoprotein NP_345336.1 791420 D 170187 CDS NP_345337.1 15900733 930796 792616..794151 1 NC_003028.3 sugar ABC transporter ATP-binding protein 794151 930796 SP_0846 Streptococcus pneumoniae TIGR4 sugar ABC transporter ATP-binding protein NP_345337.1 792616 D 170187 CDS NP_345338.1 15900734 930797 794144..795202 1 NC_003028.3 sugar ABC transporter permease 795202 930797 SP_0847 Streptococcus pneumoniae TIGR4 sugar ABC transporter permease NP_345338.1 794144 D 170187 CDS NP_345339.1 15900735 930798 795205..796161 1 NC_003028.3 similar to GB:AL009126; identified by sequence similarity; sugar ABC transporter permease 796161 930798 SP_0848 Streptococcus pneumoniae TIGR4 sugar ABC transporter permease NP_345339.1 795205 D 170187 CDS NP_345340.1 15900736 930801 complement(797560..798201) 1 NC_003028.3 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 798201 930801 SP_0851 Streptococcus pneumoniae TIGR4 glycerol-3-phosphate acyltransferase PlsY NP_345340.1 797560 R 170187 CDS NP_345341.1 15900737 930802 798337..800280 1 NC_003028.3 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 800280 930802 SP_0852 Streptococcus pneumoniae TIGR4 DNA topoisomerase IV subunit B NP_345341.1 798337 D 170187 CDS NP_345342.1 15900738 930803 800280..800387 1 NC_003028.3 hypothetical protein 800387 930803 SP_0853 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345342.1 800280 D 170187 CDS NP_345343.1 15900739 930804 800401..800526 1 NC_003028.3 hypothetical protein 800526 930804 SP_0854 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345343.1 800401 D 170187 CDS NP_345344.1 15900740 930805 800700..803171 1 NC_003028.3 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 803171 930805 SP_0855 Streptococcus pneumoniae TIGR4 DNA topoisomerase IV subunit A NP_345344.1 800700 D 170187 CDS NP_345345.1 15900741 930806 803303..804325 1 NC_003028.3 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 804325 930806 SP_0856 Streptococcus pneumoniae TIGR4 branched-chain amino acid aminotransferase NP_345345.1 803303 D 170187 CDS NP_345346.1 15900742 930808 805150..805839 1 NC_003028.3 similar to GP:6968020; identified by sequence similarity; hypothetical protein 805839 930808 SP_0858 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345346.1 805150 D 170187 CDS NP_345347.1 15900743 930809 805836..806759 1 NC_003028.3 hypothetical protein 806759 930809 SP_0859 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345347.1 805836 D 170187 CDS NP_345348.1 15900744 930810 806774..807418 1 NC_003028.3 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 807418 930810 SP_0860 Streptococcus pneumoniae TIGR4 pyrrolidone-carboxylate peptidase NP_345348.1 806774 D 170187 CDS NP_345349.1 15900745 930811 807586..807816 1 NC_003028.3 hypothetical protein 807816 930811 SP_0861 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345349.1 807586 D 170187 CDS NP_345350.1 15900746 930814 808189..809391 1 NC_003028.3 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 809391 rpsA 930814 rpsA Streptococcus pneumoniae TIGR4 30S ribosomal protein S1 NP_345350.1 808189 D 170187 CDS NP_345351.1 15900747 930816 810997..811494 1 NC_003028.3 hypothetical protein 811494 930816 SP_0864 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345351.1 810997 D 170187 CDS NP_345352.1 15900748 930817 811494..813149 1 NC_003028.3 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 813149 930817 SP_0865 Streptococcus pneumoniae TIGR4 DNA polymerase III subunits gamma and tau NP_345352.1 811494 D 170187 CDS NP_345353.1 15900749 930818 813177..813371 1 NC_003028.3 hypothetical protein 813371 930818 SP_0866 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345353.1 813177 D 170187 CDS NP_345354.1 15900750 930819 813521..814291 1 NC_003028.3 ABC transporter ATP-binding protein 814291 930819 SP_0867 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345354.1 813521 D 170187 CDS NP_345355.1 15900751 930820 814319..815581 1 NC_003028.3 hypothetical protein 815581 930820 SP_0868 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345355.1 814319 D 170187 CDS NP_345356.1 15900752 930821 815592..816818 1 NC_003028.3 class-V aminotransferase 816818 930821 SP_0869 Streptococcus pneumoniae TIGR4 class-V aminotransferase NP_345356.1 815592 D 170187 CDS NP_345357.1 15900753 930822 816805..817245 1 NC_003028.3 NifU family protein 817245 930822 SP_0870 Streptococcus pneumoniae TIGR4 NifU family protein NP_345357.1 816805 D 170187 CDS NP_345358.1 15900754 930823 817299..818711 1 NC_003028.3 identified by match to PFAM protein family HMM PF01458; intein-containing protein 818711 930823 SP_0871 Streptococcus pneumoniae TIGR4 intein-containing protein NP_345358.1 817299 D 170187 CDS NP_345359.1 15900755 930824 complement(818942..820183) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00768; D-alanyl-D-alanine carboxypeptidase 820183 930824 SP_0872 Streptococcus pneumoniae TIGR4 D-alanyl-D-alanine carboxypeptidase NP_345359.1 818942 R 170187 CDS NP_345360.1 15900756 930825 820286..821395 1 NC_003028.3 hypothetical protein 821395 930825 SP_0873 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345360.1 820286 D 170187 CDS NP_345361.1 15900757 930826 complement(822274..822381) 1 NC_003028.3 hypothetical protein 822381 930826 SP_0874 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345361.1 822274 R 170187 CDS NP_345362.1 15900758 930828 822707..823447 1 NC_003028.3 lactose phosphotransferase system repressor 823447 930828 SP_0875 Streptococcus pneumoniae TIGR4 lactose phosphotransferase system repressor NP_345362.1 822707 D 170187 CDS NP_345363.1 15900759 930829 823444..824355 1 NC_003028.3 1-phosphofructokinase 824355 930829 SP_0876 Streptococcus pneumoniae TIGR4 1-phosphofructokinase NP_345363.1 823444 D 170187 CDS NP_345364.1 15900760 930830 824352..826304 1 NC_003028.3 PTS system fructose specific transporter subunit IIABC 826304 930830 SP_0877 Streptococcus pneumoniae TIGR4 PTS system fructose specific transporter subunit IIABC NP_345364.1 824352 D 170187 CDS NP_345365.1 15900761 930831 826390..828693 1 NC_003028.3 identified by match to PFAM protein family HMM PF01580; SpoE family protein 828693 930831 SP_0878 Streptococcus pneumoniae TIGR4 SpoE family protein NP_345365.1 826390 D 170187 CDS NP_345366.1 15900762 930832 complement(828738..829271) 1 NC_003028.3 hypothetical protein 829271 930832 SP_0879 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345366.1 828738 R 170187 CDS NP_345367.1 15900763 930833 829304..830446 1 NC_003028.3 class-V aminotransferase 830446 930833 SP_0880 Streptococcus pneumoniae TIGR4 class-V aminotransferase NP_345367.1 829304 D 170187 CDS NP_345368.1 15900764 930834 830455..831669 1 NC_003028.3 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 831669 930834 SP_0881 Streptococcus pneumoniae TIGR4 thiamine biosynthesis protein ThiI NP_345368.1 830455 D 170187 CDS NP_345369.1 15900765 930835 831804..832628 1 NC_003028.3 hypothetical protein 832628 930835 SP_0882 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345369.1 831804 D 170187 CDS NP_345370.1 15900766 930836 832650..832985 1 NC_003028.3 hypothetical protein 832985 930836 SP_0883 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345370.1 832650 D 170187 CDS NP_345371.1 15900767 930837 832982..833389 1 NC_003028.3 hypothetical protein 833389 930837 SP_0884 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345371.1 832982 D 170187 CDS NP_345372.1 15900768 930838 833402..834568 1 NC_003028.3 hypothetical protein 834568 930838 SP_0885 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345372.1 833402 D 170187 CDS NP_345373.1 15900769 930839 835075..836568 1 NC_003028.3 type I restriction-modification system, M subunit 836568 930839 SP_0886 Streptococcus pneumoniae TIGR4 type I restriction-modification system, M subunit NP_345373.1 835075 D 170187 CDS NP_345374.1 15900770 930840 836581..837702 1 NC_003028.3 type I restriction-modification system subunit S 837702 930840 SP_0887 Streptococcus pneumoniae TIGR4 type I restriction-modification system subunit S NP_345374.1 836581 D 170187 CDS NP_345375.1 15900771 930841 837762..837998 1 NC_003028.3 hypothetical protein 837998 930841 SP_0888 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345375.1 837762 D 170187 CDS NP_345376.1 15900772 930842 837995..838408 1 NC_003028.3 hypothetical protein 838408 930842 SP_0889 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345376.1 837995 D 170187 CDS NP_345377.1 15900773 930843 838526..839491 1 NC_003028.3 phage integrase family integrase/recombinase 839491 930843 SP_0890 Streptococcus pneumoniae TIGR4 phage integrase family integrase/recombinase NP_345377.1 838526 D 170187 CDS NP_345378.1 15900774 930844 839436..840095 1 NC_003028.3 type I restriction-modification system subunit S 840095 930844 SP_0891 Streptococcus pneumoniae TIGR4 type I restriction-modification system subunit S NP_345378.1 839436 D 170187 CDS NP_345379.1 15900775 930845 840200..843475 1 NC_003028.3 type I restriction-modification system, R subunit 843475 930845 SP_0892 Streptococcus pneumoniae TIGR4 type I restriction-modification system, R subunit NP_345379.1 840200 D 170187 CDS NP_345380.1 15900776 930846 complement(843981..844451) 1 NC_003028.3 similar to GB:M27869 SP:P17893 PID:142450 PID:143401 PID:1303922; identified by sequence similarity; transcriptional repressor 844451 930846 SP_0893 Streptococcus pneumoniae TIGR4 transcriptional repressor NP_345380.1 843981 R 170187 CDS NP_345381.1 15900777 930847 complement(844468..846741) 1 NC_003028.3 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase 846741 930847 SP_0894 Streptococcus pneumoniae TIGR4 x-prolyl-dipeptidyl aminopeptidase NP_345381.1 844468 R 170187 CDS NP_345382.1 15900778 930848 847061..850189 1 NC_003028.3 Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 850189 dnaE 930848 dnaE Streptococcus pneumoniae TIGR4 DNA polymerase III DnaE NP_345382.1 847061 D 170187 CDS NP_345383.1 15900779 930849 850271..851278 1 NC_003028.3 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 851278 pfkA 930849 pfkA Streptococcus pneumoniae TIGR4 6-phosphofructokinase NP_345383.1 850271 D 170187 CDS NP_345384.1 15900780 930850 851337..852842 1 NC_003028.3 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 852842 930850 SP_0897 Streptococcus pneumoniae TIGR4 pyruvate kinase NP_345384.1 851337 D 170187 CDS NP_345385.1 15900781 930852 854646..855518 1 NC_003028.3 hypothetical protein 855518 930852 SP_0899 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345385.1 854646 D 170187 CDS NP_345386.1 15900782 930854 856151..856462 1 NC_003028.3 hypothetical protein 856462 930854 SP_0901 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345386.1 856151 D 170187 CDS NP_345387.2 118090029 930855 856466..857182 1 NC_003028.3 hypothetical protein 857182 930855 SP_0902 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345387.2 856466 D 170187 CDS NP_345389.1 15900785 930857 complement(857311..858126) 1 NC_003028.3 hypothetical protein 858126 930857 SP_0904 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345389.1 857311 R 170187 CDS NP_345390.1 15900786 930858 complement(858123..859028) 1 NC_003028.3 hypothetical protein 859028 930858 SP_0905 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345390.1 858123 R 170187 CDS NP_345391.1 15900787 930859 complement(859029..859160) 1 NC_003028.3 hypothetical protein 859160 930859 SP_0906 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345391.1 859029 R 170187 CDS NP_345392.1 15900788 930860 859370..860737 1 NC_003028.3 similar to GP:5823217; identified by sequence similarity; hypothetical protein 860737 930860 SP_0907 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345392.1 859370 D 170187 CDS NP_345393.1 15900789 930861 860839..862968 1 NC_003028.3 transcriptional regulator 862968 930861 SP_0908 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_345393.1 860839 D 170187 CDS NP_345394.1 15900790 930862 862955..863404 1 NC_003028.3 hypothetical protein 863404 930862 SP_0909 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345394.1 862955 D 170187 CDS NP_345395.1 15900791 930863 863462..863734 1 NC_003028.3 hypothetical protein 863734 930863 SP_0910 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345395.1 863462 D 170187 CDS NP_345396.1 15900792 930864 complement(864088..864279) 1 NC_003028.3 hypothetical protein 864279 930864 SP_0911 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345396.1 864088 R 170187 CDS NP_345397.1 15900793 930865 864707..865465 1 NC_003028.3 ABC transporter ATP-binding protein 865465 930865 SP_0912 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345397.1 864707 D 170187 CDS NP_345398.1 15900794 930866 865467..867455 1 NC_003028.3 ABC transporter permease 867455 930866 SP_0913 Streptococcus pneumoniae TIGR4 ABC transporter permease NP_345398.1 865467 D 170187 CDS NP_345399.1 15900795 930868 complement(868167..869162) 1 NC_003028.3 IS1239 transposase 869162 930868 SP_0915 Streptococcus pneumoniae TIGR4 IS1239 transposase NP_345399.1 868167 R 170187 CDS NP_345400.1 15900796 930869 869869..871344 1 NC_003028.3 identified by match to PFAM protein family HMM PF01276; lysine decarboxylase 871344 930869 SP_0916 Streptococcus pneumoniae TIGR4 lysine decarboxylase NP_345400.1 869869 D 170187 CDS NP_345401.1 15900797 930870 complement(871310..872026) 1 NC_003028.3 pilin gene inverting-like protein 872026 930870 SP_0917 Streptococcus pneumoniae TIGR4 pilin gene inverting-like protein NP_345401.1 871310 R 170187 CDS NP_345402.1 15900798 930871 872282..873142 1 NC_003028.3 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 873142 930871 SP_0918 Streptococcus pneumoniae TIGR4 spermidine synthase NP_345402.1 872282 D 170187 CDS NP_345403.1 15900799 930872 873139..874398 1 NC_003028.3 hypothetical protein 874398 930872 SP_0919 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345403.1 873139 D 170187 CDS NP_345404.1 15900800 930873 874398..875525 1 NC_003028.3 similar to GB:D31783 PID:498170; identified by sequence similarity; carboxynorspermidine decarboxylase 875525 930873 SP_0920 Streptococcus pneumoniae TIGR4 carboxynorspermidine decarboxylase NP_345404.1 874398 D 170187 CDS NP_345405.1 15900801 930874 875522..876607 1 NC_003028.3 catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis; agmatine deiminase 876607 930874 SP_0921 Streptococcus pneumoniae TIGR4 agmatine deiminase NP_345405.1 875522 D 170187 CDS NP_345406.1 15900802 930875 876617..877492 1 NC_003028.3 identified by match to PFAM protein family HMM PF00795; carbon-nitrogen hydrolase 877492 930875 SP_0922 Streptococcus pneumoniae TIGR4 carbon-nitrogen hydrolase NP_345406.1 876617 D 170187 CDS NP_345407.1 15900803 930876 complement(877673..878482) 1 NC_003028.3 Cof family protein 878482 930876 SP_0923 Streptococcus pneumoniae TIGR4 Cof family protein NP_345407.1 877673 R 170187 CDS NP_345408.1 15900804 930877 878754..878975 1 NC_003028.3 hypothetical protein 878975 930877 SP_0924 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345408.1 878754 D 170187 CDS NP_345409.1 15900805 930878 879029..879700 1 NC_003028.3 hypothetical protein 879700 930878 SP_0925 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345409.1 879029 D 170187 CDS NP_345410.1 15900806 930879 complement(879752..879949) 1 NC_003028.3 hypothetical protein 879949 930879 SP_0926 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345410.1 879752 R 170187 CDS NP_345411.1 15900807 930880 879942..880850 1 NC_003028.3 LysR family transcriptional regulator 880850 930880 SP_0927 Streptococcus pneumoniae TIGR4 LysR family transcriptional regulator NP_345411.1 879942 D 170187 CDS NP_345412.1 15900808 930881 880847..881308 1 NC_003028.3 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 881308 930881 SP_0928 Streptococcus pneumoniae TIGR4 lipoprotein signal peptidase NP_345412.1 880847 D 170187 CDS NP_345413.1 15900809 930882 881298..882185 1 NC_003028.3 ribosomal large subunit pseudouridine synthase D 882185 930882 SP_0929 Streptococcus pneumoniae TIGR4 ribosomal large subunit pseudouridine synthase D NP_345413.1 881298 D 170187 CDS NP_345414.1 15900810 930883 882188..884071 1 NC_003028.3 choline binding protein E 884071 930883 SP_0930 Streptococcus pneumoniae TIGR4 choline binding protein E NP_345414.1 882188 D 170187 CDS NP_345415.1 15900811 930884 884172..885281 1 NC_003028.3 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 885281 930884 SP_0931 Streptococcus pneumoniae TIGR4 gamma-glutamyl kinase NP_345415.1 884172 D 170187 CDS NP_345416.1 15900812 930885 885291..886553 1 NC_003028.3 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 886553 proA 930885 proA Streptococcus pneumoniae TIGR4 gamma-glutamyl phosphate reductase NP_345416.1 885291 D 170187 CDS NP_345417.1 15900813 930886 886557..887354 1 NC_003028.3 identified by match to PFAM protein family HMM PF01089; pyrroline-5-carboxylate reductase 887354 930886 SP_0933 Streptococcus pneumoniae TIGR4 pyrroline-5-carboxylate reductase NP_345417.1 886557 D 170187 CDS NP_345418.1 15900814 930887 887364..887462 1 NC_003028.3 hypothetical protein 887462 930887 SP_0934 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345418.1 887364 D 170187 CDS NP_345419.1 15900815 930888 887470..888108 1 NC_003028.3 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 888108 tmk 930888 tmk Streptococcus pneumoniae TIGR4 thymidylate kinase NP_345419.1 887470 D 170187 CDS NP_345420.1 15900816 930889 888105..888995 1 NC_003028.3 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 888995 930889 SP_0936 Streptococcus pneumoniae TIGR4 DNA polymerase III subunit delta' NP_345420.1 888105 D 170187 CDS NP_345421.1 15900817 930890 889035..889352 1 NC_003028.3 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 889352 930890 SP_0937 Streptococcus pneumoniae TIGR4 DNA replication intiation control protein YabA NP_345421.1 889035 D 170187 CDS NP_345422.1 15900818 930891 889355..890224 1 NC_003028.3 identified by match to PFAM protein family HMM PF00590; tetrapyrrole methylase 890224 930891 SP_0938 Streptococcus pneumoniae TIGR4 tetrapyrrole methylase NP_345422.1 889355 D 170187 CDS NP_345423.1 15900819 930892 890451..890969 1 NC_003028.3 hypothetical protein 890969 930892 SP_0939 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345423.1 890451 D 170187 CDS NP_345424.1 15900820 930894 complement(891713..892102) 1 NC_003028.3 similar to PID:763133; identified by sequence similarity; IS1381 transposase protein B 892102 930894 SP_0941 Streptococcus pneumoniae TIGR4 IS1381 transposase protein B NP_345424.1 891713 R 170187 CDS NP_345425.1 15900821 930895 complement(892119..892517) 1 NC_003028.3 similar to PID:763133; identified by sequence similarity; IS1381 transposase protein A 892517 930895 SP_0942 Streptococcus pneumoniae TIGR4 IS1381 transposase protein A NP_345425.1 892119 R 170187 CDS NP_345426.1 15900822 930896 892924..894294 1 NC_003028.3 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 894294 930896 SP_0943 Streptococcus pneumoniae TIGR4 tRNA (uracil-5-)-methyltransferase Gid NP_345426.1 892924 D 170187 CDS NP_345427.1 15900823 930897 894372..895115 1 NC_003028.3 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 895115 pyrH 930897 pyrH Streptococcus pneumoniae TIGR4 uridylate kinase NP_345427.1 894372 D 170187 CDS NP_345428.1 15900824 930898 895124..895681 1 NC_003028.3 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 895681 frr 930898 frr Streptococcus pneumoniae TIGR4 ribosome recycling factor NP_345428.1 895124 D 170187 CDS NP_345429.1 15900825 930899 895741..896595 1 NC_003028.3 hypothetical protein 896595 930899 SP_0946 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345429.1 895741 D 170187 CDS NP_345430.1 15900826 930900 896604..896819 1 NC_003028.3 hypothetical protein 896819 930900 SP_0947 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345430.1 896604 D 170187 CDS NP_345431.1 15900827 930901 896905..897873 1 NC_003028.3 similar to SP:P46343 PID:902050 PID:1303821 GB:AL009126; identified by sequence similarity; PhoH family protein 897873 930901 SP_0948 Streptococcus pneumoniae TIGR4 PhoH family protein NP_345431.1 896905 D 170187 CDS NP_345432.1 15900828 930903 898939..899439 1 NC_003028.3 acetyltransferase 899439 930903 SP_0950 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345432.1 898939 D 170187 CDS NP_345433.1 15900829 930904 899442..899669 1 NC_003028.3 hypothetical protein 899669 930904 SP_0951 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345433.1 899442 D 170187 CDS NP_345434.1 15900830 930906 901345..901914 1 NC_003028.3 acetyltransferase 901914 930906 SP_0953 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345434.1 901345 D 170187 CDS NP_345435.1 15900831 930907 901982..902632 1 NC_003028.3 competence protein CelA 902632 930907 SP_0954 Streptococcus pneumoniae TIGR4 competence protein CelA NP_345435.1 901982 D 170187 CDS NP_345436.1 15900832 930908 902616..904856 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00361; competence protein CelB 904856 930908 SP_0955 Streptococcus pneumoniae TIGR4 competence protein CelB NP_345436.1 902616 D 170187 CDS NP_345437.1 15900833 930910 905035..905223 1 NC_003028.3 hypothetical protein 905223 930910 SP_0956 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345437.1 905035 D 170187 CDS NP_345438.1 15900834 930911 905256..905843 1 NC_003028.3 ABC transporter ATP-binding protein 905843 930911 SP_0957 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345438.1 905256 D 170187 CDS NP_345439.1 15900835 930912 905847..907031 1 NC_003028.3 hypothetical protein 907031 930912 SP_0958 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345439.1 905847 D 170187 CDS NP_345440.1 15900836 930913 907315..907872 1 NC_003028.3 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 907872 infC 930913 infC Streptococcus pneumoniae TIGR4 translation initiation factor IF-3 NP_345440.1 907315 D 170187 CDS NP_345441.1 15900837 931101 907905..908105 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00001; 50S ribosomal protein L35 908105 rpmI 931101 rpmI Streptococcus pneumoniae TIGR4 50S ribosomal protein L35 NP_345441.1 907905 D 170187 CDS NP_345442.1 15900838 931131 908157..908516 1 NC_003028.3 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 908516 rplT 931131 rplT Streptococcus pneumoniae TIGR4 50S ribosomal protein L20 NP_345442.1 908157 D 170187 CDS NP_345443.1 15900839 931133 908574..908954 1 NC_003028.3 identified by match to PFAM protein family HMM PF00903; lactoylglutathione lyase 908954 931133 SP_0962 Streptococcus pneumoniae TIGR4 lactoylglutathione lyase NP_345443.1 908574 D 170187 CDS NP_345444.1 15900840 931158 909252..910004 1 NC_003028.3 responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+); dihydroorotate dehydrogenase electron transfer subunit 910004 931158 SP_0963 Streptococcus pneumoniae TIGR4 dihydroorotate dehydrogenase electron transfer subunit NP_345444.1 909252 D 170187 CDS NP_345445.1 15900841 931173 910015..910953 1 NC_003028.3 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 910953 931173 SP_0964 Streptococcus pneumoniae TIGR4 dihydroorotate dehydrogenase 1B NP_345445.1 910015 D 170187 CDS NP_345446.1 15900842 931241 911052..913028 1 NC_003028.3 endo-beta-N-acetylglucosaminidase 913028 931241 SP_0965 Streptococcus pneumoniae TIGR4 endo-beta-N-acetylglucosaminidase NP_345446.1 911052 D 170187 CDS NP_345447.1 15900843 931286 complement(913089..914744) 1 NC_003028.3 similar to GP:6175915; identified by sequence similarity; adherence and virulence protein A 914744 931286 SP_0966 Streptococcus pneumoniae TIGR4 adherence and virulence protein A NP_345447.1 913089 R 170187 CDS NP_345448.1 15900844 931314 914849..915346 1 NC_003028.3 metalloprotease 915346 931314 SP_0967 Streptococcus pneumoniae TIGR4 metalloprotease NP_345448.1 914849 D 170187 CDS NP_345449.1 15900845 931321 915327..915722 1 NC_003028.3 identified by match to PFAM protein family HMM PF01219; diacylglycerol kinase 915722 931321 SP_0968 Streptococcus pneumoniae TIGR4 diacylglycerol kinase NP_345449.1 915327 D 170187 CDS NP_345450.1 15900846 931324 915739..916638 1 NC_003028.3 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 916638 era 931324 era Streptococcus pneumoniae TIGR4 GTP-binding protein Era NP_345450.1 915739 D 170187 CDS NP_345451.1 15900847 931346 916687..917511 1 NC_003028.3 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 917511 931346 SP_0970 Streptococcus pneumoniae TIGR4 formamidopyrimidine-DNA glycosylase NP_345451.1 916687 D 170187 CDS NP_345452.1 15900848 931426 917511..918116 1 NC_003028.3 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 918116 coaE 931426 coaE Streptococcus pneumoniae TIGR4 dephospho-CoA kinase NP_345452.1 917511 D 170187 CDS NP_345453.1 15900849 931481 918103..919302 1 NC_003028.3 multi-drug resistance efflux pump 919302 931481 SP_0972 Streptococcus pneumoniae TIGR4 multi-drug resistance efflux pump NP_345453.1 918103 D 170187 CDS NP_345454.1 15900850 931486 919302..919451 1 NC_003028.3 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 919451 rpmG 931486 rpmG Streptococcus pneumoniae TIGR4 50S ribosomal protein L33 NP_345454.1 919302 D 170187 CDS NP_345455.1 15900851 931487 919491..919724 1 NC_003028.3 preprotein translocase subunit SecG 919724 secG 931487 secG Streptococcus pneumoniae TIGR4 preprotein translocase subunit SecG NP_345455.1 919491 D 170187 CDS NP_345456.1 15900852 931488 919826..922180 1 NC_003028.3 identified by match to PFAM protein family HMM PF00773; VacB/Rnb family exoribonuclease 922180 931488 SP_0975 Streptococcus pneumoniae TIGR4 VacB/Rnb family exoribonuclease NP_345456.1 919826 D 170187 CDS NP_345457.1 15900853 931489 922143..922610 1 NC_003028.3 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 922610 smpB 931489 smpB Streptococcus pneumoniae TIGR4 SsrA-binding protein NP_345457.1 922143 D 170187 CDS NP_345458.1 15900854 931490 922626..923486 1 NC_003028.3 with TehA confers resistance to tellurite; tellurite resistance protein TehB 923486 931490 SP_0977 Streptococcus pneumoniae TIGR4 tellurite resistance protein TehB NP_345458.1 922626 D 170187 CDS NP_345459.1 15900855 931491 923559..924512 1 NC_003028.3 similar to GP:3211759; identified by sequence similarity; competence protein CoiA 924512 931491 SP_0978 Streptococcus pneumoniae TIGR4 competence protein CoiA NP_345459.1 923559 D 170187 CDS NP_345460.1 15900856 931492 924531..926333 1 NC_003028.3 identified by match to PFAM protein family HMM PF01432; oligoendopeptidase F 926333 931492 SP_0979 Streptococcus pneumoniae TIGR4 oligoendopeptidase F NP_345460.1 924531 D 170187 CDS NP_345461.1 15900857 931493 926335..927048 1 NC_003028.3 identified by match to PFAM protein family HMM PF01596; O-methyltransferase 927048 931493 SP_0980 Streptococcus pneumoniae TIGR4 O-methyltransferase NP_345461.1 926335 D 170187 CDS NP_345462.1 15900858 931494 927115..928056 1 NC_003028.3 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase protein PrsA 928056 prsA 931494 prsA Streptococcus pneumoniae TIGR4 foldase protein PrsA NP_345462.1 927115 D 170187 CDS NP_345463.1 15900859 931497 complement(929276..929896) 1 NC_003028.3 phosphoglycerate mutase 929896 931497 SP_0984 Streptococcus pneumoniae TIGR4 phosphoglycerate mutase NP_345463.1 929276 R 170187 CDS NP_345464.1 15900860 931498 complement(929896..930378) 1 NC_003028.3 regulatory protein 930378 931498 SP_0985 Streptococcus pneumoniae TIGR4 regulatory protein NP_345464.1 929896 R 170187 CDS NP_345465.1 15900861 931499 complement(930378..931220) 1 NC_003028.3 hypothetical protein 931220 931499 SP_0986 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345465.1 930378 R 170187 CDS NP_345466.1 15900862 931500 complement(931315..932115) 1 NC_003028.3 hypothetical protein 932115 931500 SP_0987 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345466.1 931315 R 170187 CDS NP_345467.1 15900863 931501 932259..933638 1 NC_003028.3 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 933638 glmU 931501 glmU Streptococcus pneumoniae TIGR4 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase NP_345467.1 932259 D 170187 CDS NP_345468.1 15900864 931502 933648..934193 1 NC_003028.3 MutT/nudix family protein 934193 931502 SP_0989 Streptococcus pneumoniae TIGR4 MutT/nudix family protein NP_345468.1 933648 D 170187 CDS NP_345469.1 15900865 931503 934172..934519 1 NC_003028.3 hypothetical protein 934519 931503 SP_0990 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345469.1 934172 D 170187 CDS NP_345470.1 15900866 931504 934536..935228 1 NC_003028.3 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 935228 931504 SP_0991 Streptococcus pneumoniae TIGR4 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase NP_345470.1 934536 D 170187 CDS NP_345471.1 15900867 931505 935305..935796 1 NC_003028.3 hypothetical protein 935796 931505 SP_0992 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345471.1 935305 D 170187 CDS NP_345472.1 15900868 931506 935894..936484 1 NC_003028.3 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 936484 931506 SP_0993 Streptococcus pneumoniae TIGR4 DNA polymerase III subunit epsilon NP_345472.1 935894 D 170187 CDS NP_345473.1 15900869 931507 936487..938256 1 NC_003028.3 hypothetical protein 938256 931507 SP_0994 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345473.1 936487 D 170187 CDS YP_873930.1 118090035 931508 938452..938799 1 NC_003028.3 Orf1; IS630-Spn1 transposase 938799 931508 SP_0995 Streptococcus pneumoniae TIGR4 IS630-Spn1 transposase YP_873930.1 938452 D 170187 CDS NP_345474.1 15900870 931510 939279..939479 1 NC_003028.3 hypothetical protein 939479 931510 SP_0997 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345474.1 939279 D 170187 CDS NP_345475.1 15900871 931511 939626..939925 1 NC_003028.3 hypothetical protein 939925 931511 SP_0998 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345475.1 939626 D 170187 CDS NP_345476.1 15900872 931512 940156..940863 1 NC_003028.3 similar to GP:6714962; identified by sequence similarity; cytochrome c-type biogenesis protein CcdA 940863 931512 SP_0999 Streptococcus pneumoniae TIGR4 cytochrome c-type biogenesis protein CcdA NP_345476.1 940156 D 170187 CDS NP_345477.1 15900873 931513 940874..941431 1 NC_003028.3 thioredoxin 941431 931513 SP_1000 Streptococcus pneumoniae TIGR4 thioredoxin NP_345477.1 940874 D 170187 CDS NP_345478.1 15900874 931514 941805..943196 1 NC_003028.3 identified by match to PFAM protein family HMM PF00324; amino acid permease 943196 931514 SP_1001 Streptococcus pneumoniae TIGR4 amino acid permease NP_345478.1 941805 D 170187 CDS NP_345479.1 15900875 931515 943339..944256 1 NC_003028.3 identified by match to PFAM protein family HMM PF01297; adhesion lipoprotein 944256 931515 SP_1002 Streptococcus pneumoniae TIGR4 adhesion lipoprotein NP_345479.1 943339 D 170187 CDS NP_345480.1 15900876 931516 944264..946783 1 NC_003028.3 hypothetical protein 946783 931516 SP_1003 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345480.1 944264 D 170187 CDS NP_345481.1 15900877 931517 946993..950112 1 NC_003028.3 hypothetical protein 950112 931517 SP_1004 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345481.1 946993 D 170187 CDS NP_345482.1 15900878 931519 complement(951620..951823) 1 NC_003028.3 hypothetical protein 951823 931519 SP_1006 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345482.1 951620 R 170187 CDS NP_345483.1 15900879 931520 951806..952435 1 NC_003028.3 hypothetical protein 952435 931520 SP_1007 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345483.1 951806 D 170187 CDS NP_345484.1 15900880 931521 complement(952471..953694) 1 NC_003028.3 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 953694 931521 SP_1008 Streptococcus pneumoniae TIGR4 peptidase T NP_345484.1 952471 R 170187 CDS NP_345485.1 15900881 931522 953849..954943 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00109; ferrochelatase 954943 931522 SP_1009 Streptococcus pneumoniae TIGR4 ferrochelatase NP_345485.1 953849 D 170187 CDS NP_345486.1 15900882 931523 complement(954985..955362) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01741; large conductance mechanosensitive channel protein MscL 955362 931523 SP_1010 Streptococcus pneumoniae TIGR4 large conductance mechanosensitive channel protein MscL NP_345486.1 954985 R 170187 CDS NP_345487.1 15900883 931524 complement(955444..955875) 1 NC_003028.3 similar to GB:X73124 SP:P39602 PID:413958 GB:AL009126; identified by sequence similarity; GtrA family protein 955875 931524 SP_1011 Streptococcus pneumoniae TIGR4 GtrA family protein NP_345487.1 955444 R 170187 CDS NP_345488.1 15900884 931525 955998..956507 1 NC_003028.3 hypothetical protein 956507 931525 SP_1012 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345488.1 955998 D 170187 CDS NP_345489.1 15900885 931527 957021..958097 1 NC_003028.3 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 958097 931527 SP_1013 Streptococcus pneumoniae TIGR4 aspartate-semialdehyde dehydrogenase NP_345489.1 957021 D 170187 CDS NP_345490.1 15900886 931528 958153..959088 1 NC_003028.3 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 959088 dapA 931528 dapA Streptococcus pneumoniae TIGR4 dihydrodipicolinate synthase NP_345490.1 958153 D 170187 CDS NP_345491.1 15900887 931530 complement(960558..961931) 1 NC_003028.3 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 961931 trmE 931530 trmE Streptococcus pneumoniae TIGR4 tRNA modification GTPase TrmE NP_345491.1 960558 R 170187 CDS NP_345492.1 15900888 931531 complement(962068..962250) 1 NC_003028.3 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 962250 931531 SP_1017 Streptococcus pneumoniae TIGR4 4-oxalocrotonate tautomerase NP_345492.1 962068 R 170187 CDS NP_345493.1 15900889 931532 962374..962973 1 NC_003028.3 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 962973 931532 SP_1018 Streptococcus pneumoniae TIGR4 thymidine kinase NP_345493.1 962374 D 170187 CDS NP_345494.1 15900890 931533 962963..963442 1 NC_003028.3 acetyltransferase 963442 931533 SP_1019 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345494.1 962963 D 170187 CDS NP_345495.1 15900891 931534 963452..964531 1 NC_003028.3 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 964531 prfA 931534 prfA Streptococcus pneumoniae TIGR4 peptide chain release factor 1 NP_345495.1 963452 D 170187 CDS NP_345496.1 15900892 931535 964531..965370 1 NC_003028.3 HemK protein 965370 931535 SP_1021 Streptococcus pneumoniae TIGR4 HemK protein NP_345496.1 964531 D 170187 CDS NP_345497.1 15900893 931536 965357..965956 1 NC_003028.3 identified by match to PFAM protein family HMM PF01300; Sua5/YciO/YrdC family protein 965956 931536 SP_1022 Streptococcus pneumoniae TIGR4 Sua5/YciO/YrdC family protein NP_345497.1 965357 D 170187 CDS NP_345498.1 15900894 931537 965958..966389 1 NC_003028.3 acetyltransferase 966389 931537 SP_1023 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345498.1 965958 D 170187 CDS NP_345499.1 15900895 931538 966451..967707 1 NC_003028.3 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 967707 glyA 931538 glyA Streptococcus pneumoniae TIGR4 serine hydroxymethyltransferase NP_345499.1 966451 D 170187 CDS NP_345500.1 15900896 931539 967682..968689 1 NC_003028.3 hypothetical protein 968689 931539 SP_1025 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345500.1 967682 D 170187 CDS NP_345501.1 15900897 931540 968689..969303 1 NC_003028.3 hypothetical protein 969303 931540 SP_1026 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345501.1 968689 D 170187 CDS NP_345502.1 15900898 931541 969377..970351 1 NC_003028.3 hypothetical protein 970351 931541 SP_1027 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345502.1 969377 D 170187 CDS NP_345503.1 15900899 931542 970320..970412 1 NC_003028.3 hypothetical protein 970412 931542 SP_1028 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345503.1 970320 D 170187 CDS NP_345504.1 15900900 931543 970425..972056 1 NC_003028.3 RNA methyltransferase 972056 931543 SP_1029 Streptococcus pneumoniae TIGR4 RNA methyltransferase NP_345504.1 970425 D 170187 CDS NP_345505.1 15900901 931544 972795..973013 1 NC_003028.3 hypothetical protein 973013 931544 SP_1030 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345505.1 972795 D 170187 CDS NP_345506.1 15900902 931545 973184..973285 1 NC_003028.3 hypothetical protein 973285 931545 SP_1031 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345506.1 973184 D 170187 CDS NP_345507.1 15900903 931546 973406..974431 1 NC_003028.3 iron-compound ABC transporter iron compound-binding protein 974431 931546 SP_1032 Streptococcus pneumoniae TIGR4 iron-compound ABC transporter iron compound-binding protein NP_345507.1 973406 D 170187 CDS NP_345508.1 15900904 931547 974409..975428 1 NC_003028.3 identified by match to PFAM protein family HMM PF01032; iron ABC transporter permease 975428 931547 SP_1033 Streptococcus pneumoniae TIGR4 iron ABC transporter permease NP_345508.1 974409 D 170187 CDS NP_345509.1 15900905 931548 975428..976435 1 NC_003028.3 identified by match to PFAM protein family HMM PF01032; iron ABC transporter permease 976435 931548 SP_1034 Streptococcus pneumoniae TIGR4 iron ABC transporter permease NP_345509.1 975428 D 170187 CDS NP_345510.1 15900906 931549 976435..977229 1 NC_003028.3 iron-compound ABC transporter ATP-binding protein 977229 931549 SP_1035 Streptococcus pneumoniae TIGR4 iron-compound ABC transporter ATP-binding protein NP_345510.1 976435 D 170187 CDS NP_345511.1 15900907 931550 complement(977345..977437) 1 NC_003028.3 hypothetical protein 977437 931550 SP_1036 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345511.1 977345 R 170187 CDS NP_345512.1 15900908 931551 977797..978006 1 NC_003028.3 similar to GB:L17341 SP:Q07606 PID:304141; identified by sequence similarity; type II restriction endonuclease 978006 931551 SP_1037 Streptococcus pneumoniae TIGR4 type II restriction endonuclease NP_345512.1 977797 D 170187 CDS NP_345513.1 15900909 931552 978131..978286 1 NC_003028.3 hypothetical protein 978286 931552 SP_1038 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345513.1 978131 D 170187 CDS NP_345514.1 15900910 931553 978970..979131 1 NC_003028.3 hypothetical protein 979131 931553 SP_1039 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345514.1 978970 D 170187 CDS NP_345515.1 15900911 931554 979223..980902 1 NC_003028.3 resolvase family site-specific recombinase 980902 931554 SP_1040 Streptococcus pneumoniae TIGR4 resolvase family site-specific recombinase NP_345515.1 979223 D 170187 CDS NP_345516.1 15900912 931555 981125..981736 1 NC_003028.3 hypothetical protein 981736 931555 SP_1041 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345516.1 981125 D 170187 CDS NP_345517.1 15900913 931556 982049..982246 1 NC_003028.3 hypothetical protein 982246 931556 SP_1042 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345517.1 982049 D 170187 CDS NP_345518.1 15900914 931557 982308..983066 1 NC_003028.3 hypothetical protein 983066 931557 SP_1043 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345518.1 982308 D 170187 CDS NP_345519.1 15900915 931558 983124..983978 1 NC_003028.3 similar to GP:7020551; identified by sequence similarity; hydrolase 983978 931558 SP_1044 Streptococcus pneumoniae TIGR4 hydrolase NP_345519.1 983124 D 170187 CDS NP_345520.1 15900916 931559 984090..984974 1 NC_003028.3 hypothetical protein 984974 931559 SP_1045 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345520.1 984090 D 170187 CDS NP_345521.1 15900917 931561 986963..987280 1 NC_003028.3 hypothetical protein 987280 931561 SP_1047 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345521.1 986963 D 170187 CDS NP_345522.1 15900918 931562 987326..987607 1 NC_003028.3 hypothetical protein 987607 931562 SP_1048 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345522.1 987326 D 170187 CDS NP_345523.1 15900919 931563 987747..987860 1 NC_003028.3 hypothetical protein 987860 931563 SP_1049 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345523.1 987747 D 170187 CDS NP_345524.1 15900920 931564 988052..988528 1 NC_003028.3 transcriptional regulator 988528 931564 SP_1050 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_345524.1 988052 D 170187 CDS NP_345525.1 15900921 931565 988528..989289 1 NC_003028.3 hypothetical protein 989289 931565 SP_1051 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345525.1 988528 D 170187 CDS NP_345526.1 15900922 931566 989317..990093 1 NC_003028.3 identified by match to PFAM protein family HMM PF02231; hypothetical protein 990093 931566 SP_1052 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345526.1 989317 D 170187 CDS NP_345527.1 15900923 931567 990096..990473 1 NC_003028.3 similar to GP:6009450; identified by sequence similarity; hypothetical protein 990473 931567 SP_1053 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345527.1 990096 D 170187 CDS NP_345528.1 15900924 931568 991304..991660 1 NC_003028.3 similar to PID:951053; identified by sequence similarity; Tn5252, ORF 10 protein 991660 931568 SP_1054 Streptococcus pneumoniae TIGR4 Tn5252, ORF 10 protein NP_345528.1 991304 D 170187 CDS NP_345529.1 15900925 931569 991665..992030 1 NC_003028.3 similar to PID:951052; identified by sequence similarity; Tn5252, ORF 9 protein 992030 931569 SP_1055 Streptococcus pneumoniae TIGR4 Tn5252, ORF 9 protein NP_345529.1 991665 D 170187 CDS NP_345530.1 15900926 931570 992017..993840 1 NC_003028.3 Tn5252, relaxase 993840 931570 SP_1056 Streptococcus pneumoniae TIGR4 Tn5252, relaxase NP_345530.1 992017 D 170187 CDS NP_345531.1 15900927 931571 993954..994820 1 NC_003028.3 transcriptional regulator PlcR 994820 931571 SP_1057 Streptococcus pneumoniae TIGR4 transcriptional regulator PlcR NP_345531.1 993954 D 170187 CDS NP_345532.1 15900928 931572 994973..995107 1 NC_003028.3 hypothetical protein 995107 931572 SP_1058 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345532.1 994973 D 170187 CDS NP_345533.1 15900929 931573 995411..995662 1 NC_003028.3 hypothetical protein 995662 931573 SP_1059 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345533.1 995411 D 170187 CDS NP_345534.1 15900930 931574 995882..996193 1 NC_003028.3 hypothetical protein 996193 931574 SP_1060 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345534.1 995882 D 170187 CDS NP_345535.1 15900931 931575 996190..997536 1 NC_003028.3 protein kinase 997536 931575 SP_1061 Streptococcus pneumoniae TIGR4 protein kinase NP_345535.1 996190 D 170187 CDS NP_345536.1 15900932 931576 997550..998467 1 NC_003028.3 ABC transporter ATP-binding protein 998467 931576 SP_1062 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345536.1 997550 D 170187 CDS NP_345537.1 15900933 931577 998464..999264 1 NC_003028.3 ABC transporter permease 999264 931577 SP_1063 Streptococcus pneumoniae TIGR4 ABC transporter permease NP_345537.1 998464 D 170187 CDS NP_345538.1 15900934 931578 999422..999895 1 NC_003028.3 IS200 family transposase 999895 931578 SP_1064 Streptococcus pneumoniae TIGR4 IS200 family transposase NP_345538.1 999422 D 170187 CDS NP_345539.1 15900935 931579 complement(1000385..1000606) 1 NC_003028.3 hypothetical protein 1000606 931579 SP_1065 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345539.1 1000385 R 170187 CDS NP_345540.1 15900936 931581 1001278..1002507 1 NC_003028.3 cell division protein FtsW 1002507 931581 SP_1067 Streptococcus pneumoniae TIGR4 cell division protein FtsW NP_345540.1 1001278 D 170187 CDS NP_345541.1 15900937 931582 1002527..1005223 1 NC_003028.3 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 1005223 931582 SP_1068 Streptococcus pneumoniae TIGR4 phosphoenolpyruvate carboxylase NP_345541.1 1002527 D 170187 CDS NP_345542.1 15900938 931583 1005606..1006640 1 NC_003028.3 hypothetical protein 1006640 931583 SP_1069 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345542.1 1005606 D 170187 CDS NP_345543.1 15900939 931584 1006709..1007575 1 NC_003028.3 hypothetical protein 1007575 931584 SP_1070 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345543.1 1006709 D 170187 CDS NP_345544.1 15900940 931585 1007572..1008330 1 NC_003028.3 ABC transporter ATP-binding protein 1008330 931585 SP_1071 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345544.1 1007572 D 170187 CDS NP_345545.1 15900941 931586 1008420..1010180 1 NC_003028.3 synthesizes RNA primers at the replication forks; DNA primase 1010180 dnaG 931586 dnaG Streptococcus pneumoniae TIGR4 DNA primase NP_345545.1 1008420 D 170187 CDS NP_345546.1 15900942 931587 1010183..1011292 1 NC_003028.3 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 1011292 931587 SP_1073 Streptococcus pneumoniae TIGR4 RNA polymerase sigma factor RpoD NP_345546.1 1010183 D 170187 CDS NP_345547.1 15900943 931588 1011306..1011635 1 NC_003028.3 hypothetical protein 1011635 931588 SP_1074 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345547.1 1011306 D 170187 CDS NP_345548.1 15900944 931589 1011777..1012793 1 NC_003028.3 glycosyl transferase CpoA 1012793 931589 SP_1075 Streptococcus pneumoniae TIGR4 glycosyl transferase CpoA NP_345548.1 1011777 D 170187 CDS NP_345549.1 15900945 931590 1012809..1014134 1 NC_003028.3 group 1 glycosyl transferase 1014134 931590 SP_1076 Streptococcus pneumoniae TIGR4 group 1 glycosyl transferase NP_345549.1 1012809 D 170187 CDS NP_345550.1 15900946 931591 1014165..1014341 1 NC_003028.3 similar to GB:AL009126; identified by sequence similarity; hypothetical protein 1014341 931591 SP_1077 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345550.1 1014165 D 170187 CDS NP_345551.1 15900947 931592 1014400..1014534 1 NC_003028.3 hypothetical protein 1014534 931592 SP_1078 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345551.1 1014400 D 170187 CDS NP_345552.1 15900948 931593 1014604..1015908 1 NC_003028.3 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1015908 obgE 931593 obgE Streptococcus pneumoniae TIGR4 GTPase ObgE NP_345552.1 1014604 D 170187 CDS NP_345553.1 15900949 931594 1015918..1016076 1 NC_003028.3 hypothetical protein 1016076 931594 SP_1080 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345553.1 1015918 D 170187 CDS NP_345554.1 15900950 931595 1017219..1018478 1 NC_003028.3 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1018478 931595 SP_1081 Streptococcus pneumoniae TIGR4 UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_345554.1 1017219 D 170187 CDS NP_345555.1 15900951 931596 1018494..1019045 1 NC_003028.3 acetyltransferase 1019045 931596 SP_1082 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345555.1 1018494 D 170187 CDS NP_345556.1 15900952 931597 1019038..1020315 1 NC_003028.3 hypothetical protein 1020315 931597 SP_1083 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345556.1 1019038 D 170187 CDS NP_345557.1 15900953 931598 1020331..1021191 1 NC_003028.3 catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 1021191 931598 SP_1084 Streptococcus pneumoniae TIGR4 methionine aminopeptidase NP_345557.1 1020331 D 170187 CDS NP_345558.1 15900954 931600 1021985..1022374 1 NC_003028.3 similar to PID:763133; identified by sequence similarity; IS1381 transposase protein B 1022374 931600 SP_1086 Streptococcus pneumoniae TIGR4 IS1381 transposase protein B NP_345558.1 1021985 D 170187 CDS NP_345559.1 15900955 931601 1022565..1024856 1 NC_003028.3 ATP-dependent DNA helicase PcrA 1024856 931601 SP_1087 Streptococcus pneumoniae TIGR4 ATP-dependent DNA helicase PcrA NP_345559.1 1022565 D 170187 CDS NP_345560.1 15900956 931602 1024899..1025579 1 NC_003028.3 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 1025579 radC 931602 radC Streptococcus pneumoniae TIGR4 DNA repair protein RadC NP_345560.1 1024899 D 170187 CDS NP_345561.1 15900957 931603 complement(1025576..1026265) 1 NC_003028.3 glutamine amidotransferase 1026265 931603 SP_1089 Streptococcus pneumoniae TIGR4 glutamine amidotransferase NP_345561.1 1025576 R 170187 CDS NP_345562.1 15900958 931604 complement(1026283..1026924) 1 NC_003028.3 modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex 1026924 931604 SP_1090 Streptococcus pneumoniae TIGR4 redox-sensing transcriptional repressor Rex NP_345562.1 1026283 R 170187 CDS NP_345563.1 15900959 931605 complement(1026940..1027032) 1 NC_003028.3 hypothetical protein 1027032 931605 SP_1091 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345563.1 1026940 R 170187 CDS NP_345564.1 15900960 931606 complement(1027007..1027258) 1 NC_003028.3 hypothetical protein 1027258 931606 SP_1092 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345564.1 1027007 R 170187 CDS NP_345565.1 15900961 931607 complement(1027230..1027577) 1 NC_003028.3 hypothetical protein 1027577 931607 SP_1093 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345565.1 1027230 R 170187 CDS NP_345566.1 15900962 931608 complement(1027582..1028664) 1 NC_003028.3 class-V aminotransferase 1028664 931608 SP_1094 Streptococcus pneumoniae TIGR4 class-V aminotransferase NP_345566.1 1027582 R 170187 CDS NP_345567.1 15900963 931609 complement(1028707..1029666) 1 NC_003028.3 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1029666 931609 SP_1095 Streptococcus pneumoniae TIGR4 ribose-phosphate pyrophosphokinase NP_345567.1 1028707 R 170187 CDS NP_345568.1 15900964 931610 complement(1029779..1030348) 1 NC_003028.3 hypothetical protein 1030348 931610 SP_1096 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345568.1 1029779 R 170187 CDS NP_345569.1 15900965 931611 1030476..1031147 1 NC_003028.3 hypothetical protein 1031147 931611 SP_1097 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345569.1 1030476 D 170187 CDS NP_345570.1 15900966 931612 1031131..1031949 1 NC_003028.3 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1031949 ppnK 931612 ppnK Streptococcus pneumoniae TIGR4 inorganic polyphosphate/ATP-NAD kinase NP_345570.1 1031131 D 170187 CDS NP_345571.1 15900967 931613 1031946..1032842 1 NC_003028.3 ribosomal large subunit pseudouridine synthase D 1032842 931613 SP_1099 Streptococcus pneumoniae TIGR4 ribosomal large subunit pseudouridine synthase D NP_345571.1 1031946 D 170187 CDS NP_345572.1 15900968 931614 1032886..1033860 1 NC_003028.3 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 1033860 eutD 931614 eutD Streptococcus pneumoniae TIGR4 phosphotransacetylase NP_345572.1 1032886 D 170187 CDS NP_345573.1 15900969 931616 complement(1035629..1035919) 1 NC_003028.3 hypothetical protein 1035919 931616 SP_1102 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345573.1 1035629 R 170187 CDS NP_345574.1 15900970 931617 complement(1035925..1036032) 1 NC_003028.3 hypothetical protein 1036032 931617 SP_1103 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345574.1 1035925 R 170187 CDS NP_345575.1 15900971 931618 1036330..1037034 1 NC_003028.3 hypothetical protein 1037034 931618 SP_1104 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345575.1 1036330 D 170187 CDS NP_345576.1 15900972 931619 1037216..1037530 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00061; 50S ribosomal protein L21 1037530 rplU 931619 rplU Streptococcus pneumoniae TIGR4 50S ribosomal protein L21 NP_345576.1 1037216 D 170187 CDS NP_345577.1 15900973 931620 1037546..1037890 1 NC_003028.3 hypothetical protein 1037890 931620 SP_1106 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345577.1 1037546 D 170187 CDS NP_345578.1 15900974 931621 1037916..1038200 1 NC_003028.3 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1038200 rpmA 931621 rpmA Streptococcus pneumoniae TIGR4 50S ribosomal protein L27 NP_345578.1 1037916 D 170187 CDS NP_345579.1 15900975 931622 complement(1038546..1038716) 1 NC_003028.3 hypothetical protein 1038716 931622 SP_1108 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345579.1 1038546 R 170187 CDS NP_345580.1 15900976 931623 complement(1038688..1038807) 1 NC_003028.3 hypothetical protein 1038807 931623 SP_1109 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345580.1 1038688 R 170187 CDS NP_345581.1 15900977 931624 1039154..1040071 1 NC_003028.3 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1040071 931624 SP_1110 Streptococcus pneumoniae TIGR4 bifunctional riboflavin kinase/FMN adenylyltransferase NP_345581.1 1039154 D 170187 CDS NP_345582.1 15900978 931625 complement(1040164..1041012) 1 NC_003028.3 hypothetical protein 1041012 931625 SP_1111 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345582.1 1040164 R 170187 CDS NP_345583.1 15900979 931626 1041154..1041993 1 NC_003028.3 degV family protein 1041993 931626 SP_1112 Streptococcus pneumoniae TIGR4 degV family protein NP_345583.1 1041154 D 170187 CDS NP_345584.1 15900980 931627 1042099..1042374 1 NC_003028.3 DNA-binding protein HU 1042374 931627 SP_1113 Streptococcus pneumoniae TIGR4 DNA-binding protein HU NP_345584.1 1042099 D 170187 CDS NP_345585.1 15900981 931628 1042800..1044701 1 NC_003028.3 ABC transporter ATP-binding protein 1044701 931628 SP_1114 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345585.1 1042800 D 170187 CDS NP_345586.1 15900982 931629 1044704..1045567 1 NC_003028.3 transcriptional regulator MutR 1045567 931629 SP_1115 Streptococcus pneumoniae TIGR4 transcriptional regulator MutR NP_345586.1 1044704 D 170187 CDS NP_345587.1 15900983 931630 1045647..1046825 1 NC_003028.3 transporter 1046825 931630 SP_1116 Streptococcus pneumoniae TIGR4 transporter NP_345587.1 1045647 D 170187 CDS NP_345588.1 15900984 931631 1046918..1048876 1 NC_003028.3 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1048876 ligA 931631 ligA Streptococcus pneumoniae TIGR4 NAD-dependent DNA ligase LigA NP_345588.1 1046918 D 170187 CDS NP_345589.1 15900985 931632 1048988..1051267 1 NC_003028.3 pullulanase 1051267 931632 SP_1118 Streptococcus pneumoniae TIGR4 pullulanase NP_345589.1 1048988 D 170187 CDS NP_345590.1 15900986 931633 1051812..1053236 1 NC_003028.3 glyceraldehyde-3-phosphate dehydrogenase 1053236 931633 SP_1119 Streptococcus pneumoniae TIGR4 glyceraldehyde-3-phosphate dehydrogenase NP_345590.1 1051812 D 170187 CDS NP_345591.1 15900987 931634 complement(1053585..1053689) 1 NC_003028.3 hypothetical protein 1053689 931634 SP_1120 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345591.1 1053585 R 170187 CDS NP_345592.1 15900988 931635 1053719..1055647 1 NC_003028.3 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 1055647 931635 SP_1121 Streptococcus pneumoniae TIGR4 glycogen branching protein NP_345592.1 1053719 D 170187 CDS NP_345593.1 15900989 931636 1055637..1056779 1 NC_003028.3 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1056779 glgC 931636 glgC Streptococcus pneumoniae TIGR4 glucose-1-phosphate adenylyltransferase NP_345593.1 1055637 D 170187 CDS NP_345594.1 15900990 931637 1056769..1057908 1 NC_003028.3 glycogen biosynthesis protein GlgD 1057908 931637 SP_1123 Streptococcus pneumoniae TIGR4 glycogen biosynthesis protein GlgD NP_345594.1 1056769 D 170187 CDS NP_345595.1 15900991 931638 1057905..1059338 1 NC_003028.3 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 1059338 glgA 931638 glgA Streptococcus pneumoniae TIGR4 glycogen synthase NP_345595.1 1057905 D 170187 CDS NP_345596.1 15900992 931640 1060051..1061166 1 NC_003028.3 hypothetical protein 1061166 931640 SP_1126 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345596.1 1060051 D 170187 CDS NP_345597.1 15900993 931641 complement(1061163..1061609) 1 NC_003028.3 hypothetical protein 1061609 931641 SP_1127 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345597.1 1061163 R 170187 CDS NP_345598.1 15900994 931642 1061773..1063077 1 NC_003028.3 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1063077 eno 931642 eno Streptococcus pneumoniae TIGR4 phosphopyruvate hydratase NP_345598.1 1061773 D 170187 CDS NP_345599.1 15900995 931643 complement(1063231..1064394) 1 NC_003028.3 phage integrase family integrase/recombinase 1064394 931643 SP_1129 Streptococcus pneumoniae TIGR4 phage integrase family integrase/recombinase NP_345599.1 1063231 R 170187 CDS NP_345600.1 15900996 931644 complement(1064469..1065317) 1 NC_003028.3 transcriptional regulator 1065317 931644 SP_1130 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_345600.1 1064469 R 170187 CDS NP_345601.1 15900997 931645 1065437..1065790 1 NC_003028.3 transcriptional regulator 1065790 931645 SP_1131 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_345601.1 1065437 D 170187 CDS NP_345602.1 15900998 931646 1065890..1066156 1 NC_003028.3 hypothetical protein 1066156 931646 SP_1132 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345602.1 1065890 D 170187 CDS NP_345603.1 15900999 931647 1066167..1066319 1 NC_003028.3 hypothetical protein 1066319 931647 SP_1133 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345603.1 1066167 D 170187 CDS NP_345604.1 15901000 931648 1066524..1067141 1 NC_003028.3 hypothetical protein 1067141 931648 SP_1134 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345604.1 1066524 D 170187 CDS NP_345605.1 15901001 931649 1067176..1067628 1 NC_003028.3 hypothetical protein 1067628 931649 SP_1135 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345605.1 1067176 D 170187 CDS NP_345606.1 15901002 931650 1067625..1068071 1 NC_003028.3 similar to GP:1813342; identified by sequence similarity; hypothetical protein 1068071 931650 SP_1136 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345606.1 1067625 D 170187 CDS NP_345607.1 15901003 931651 1068083..1068967 1 NC_003028.3 identified by match to PFAM protein family HMM PF01695; GTP-binding protein 1068967 931651 SP_1137 Streptococcus pneumoniae TIGR4 GTP-binding protein NP_345607.1 1068083 D 170187 CDS NP_345608.1 15901004 931652 complement(1068980..1069090) 1 NC_003028.3 hypothetical protein 1069090 931652 SP_1138 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345608.1 1068980 R 170187 CDS NP_345609.1 15901005 931653 1069216..1069866 1 NC_003028.3 hypothetical protein 1069866 931653 SP_1139 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345609.1 1069216 D 170187 CDS NP_345610.1 15901006 931654 1069913..1070341 1 NC_003028.3 hypothetical protein 1070341 931654 SP_1140 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345610.1 1069913 D 170187 CDS NP_345611.1 15901007 931655 1070349..1070660 1 NC_003028.3 hypothetical protein 1070660 931655 SP_1141 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345611.1 1070349 D 170187 CDS NP_345612.1 15901008 931656 1070678..1071088 1 NC_003028.3 hypothetical protein 1071088 931656 SP_1142 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345612.1 1070678 D 170187 CDS NP_345613.1 15901009 931657 1071285..1071650 1 NC_003028.3 hypothetical protein 1071650 931657 SP_1143 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345613.1 1071285 D 170187 CDS NP_345614.1 15901010 931658 1071640..1071933 1 NC_003028.3 hypothetical protein 1071933 931658 SP_1144 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345614.1 1071640 D 170187 CDS NP_345615.1 15901011 931659 1071951..1073141 1 NC_003028.3 hypothetical protein 1073141 931659 SP_1145 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345615.1 1071951 D 170187 CDS NP_345616.1 15901012 931660 1073144..1073320 1 NC_003028.3 hypothetical protein 1073320 931660 SP_1146 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345616.1 1073144 D 170187 CDS NP_345617.1 15901013 931662 complement(1073986..1074324) 1 NC_003028.3 IS630-Spn1, transposase Orf2 1074324 931662 SP_1148 Streptococcus pneumoniae TIGR4 IS630-Spn1, transposase Orf2 NP_345617.1 1073986 R 170187 CDS NP_345618.1 15901014 931663 complement(1074433..1074849) 1 NC_003028.3 IS630-Spn1, transposase Orf1 1074849 931663 SP_1149 Streptococcus pneumoniae TIGR4 IS630-Spn1, transposase Orf1 NP_345618.1 1074433 R 170187 CDS NP_345619.1 15901015 931664 complement(1075245..1075346) 1 NC_003028.3 hypothetical protein 1075346 931664 SP_1150 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345619.1 1075245 R 170187 CDS NP_345620.1 15901016 931665 1075357..1078632 1 NC_003028.3 exonuclease RexB 1078632 931665 SP_1151 Streptococcus pneumoniae TIGR4 exonuclease RexB NP_345620.1 1075357 D 170187 CDS NP_345621.1 15901017 931666 1078629..1082279 1 NC_003028.3 exonuclease RexA 1082279 931666 SP_1152 Streptococcus pneumoniae TIGR4 exonuclease RexA NP_345621.1 1078629 D 170187 CDS NP_345622.1 15901018 931667 1082494..1083672 1 NC_003028.3 hypothetical protein 1083672 931667 SP_1153 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345622.1 1082494 D 170187 CDS NP_345623.1 15901019 931668 1083881..1089895 1 NC_003028.3 identified by match to PFAM protein family HMM PF00746; immunoglobulin A1 protease 1089895 931668 SP_1154 Streptococcus pneumoniae TIGR4 immunoglobulin A1 protease NP_345623.1 1083881 D 170187 CDS NP_345624.1 15901020 931669 1090342..1091193 1 NC_003028.3 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1091193 rbgA 931669 rbgA Streptococcus pneumoniae TIGR4 ribosomal biogenesis GTPase NP_345624.1 1090342 D 170187 CDS NP_345625.1 15901021 931670 1091180..1091959 1 NC_003028.3 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1091959 rnhB 931670 rnhB Streptococcus pneumoniae TIGR4 ribonuclease HII NP_345625.1 1091180 D 170187 CDS NP_345626.1 15901022 931671 1091975..1093525 1 NC_003028.3 identified by match to PFAM protein family HMM PF00654; voltage-gated chloride channel family protein 1093525 931671 SP_1157 Streptococcus pneumoniae TIGR4 voltage-gated chloride channel family protein NP_345626.1 1091975 D 170187 CDS NP_345627.1 15901023 931672 complement(1093718..1093831) 1 NC_003028.3 hypothetical protein 1093831 931672 SP_1158 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345627.1 1093718 R 170187 CDS NP_345628.1 15901024 931673 1094109..1095179 1 NC_003028.3 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1095179 xerS 931673 xerS Streptococcus pneumoniae TIGR4 site-specific tyrosine recombinase XerS NP_345628.1 1094109 D 170187 CDS NP_345629.1 15901025 931674 complement(1095244..1096233) 1 NC_003028.3 lipoate-protein ligase 1096233 931674 SP_1160 Streptococcus pneumoniae TIGR4 lipoate-protein ligase NP_345629.1 1095244 R 170187 CDS NP_345630.1 15901026 931675 complement(1096297..1098000) 1 NC_003028.3 acetoin dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase 1098000 931675 SP_1161 Streptococcus pneumoniae TIGR4 acetoin dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase NP_345630.1 1096297 R 170187 CDS NP_345631.1 15901027 931676 complement(1098046..1099089) 1 NC_003028.3 unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain; dihydrolipoamide acetyltransferase 1099089 931676 SP_1162 Streptococcus pneumoniae TIGR4 dihydrolipoamide acetyltransferase NP_345631.1 1098046 R 170187 CDS NP_345632.1 15901028 931677 complement(1099307..1100299) 1 NC_003028.3 acetoin dehydrogenase, E1 component subunit beta 1100299 931677 SP_1163 Streptococcus pneumoniae TIGR4 acetoin dehydrogenase, E1 component subunit beta NP_345632.1 1099307 R 170187 CDS NP_345633.1 15901029 931678 complement(1100315..1101283) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00676; acetoin dehydrogenase, E1 component subunit alpha 1101283 931678 SP_1164 Streptococcus pneumoniae TIGR4 acetoin dehydrogenase, E1 component subunit alpha NP_345633.1 1100315 R 170187 CDS NP_345634.1 15901030 931679 1101330..1101440 1 NC_003028.3 hypothetical protein 1101440 931679 SP_1165 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345634.1 1101330 D 170187 CDS NP_345635.1 15901031 931680 complement(1101437..1102798) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01554; MATE efflux family protein 1102798 931680 SP_1166 Streptococcus pneumoniae TIGR4 MATE efflux family protein NP_345635.1 1101437 R 170187 CDS NP_345636.1 15901032 931681 complement(1103083..1104351) 1 NC_003028.3 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1104351 pyrC 931681 pyrC Streptococcus pneumoniae TIGR4 dihydroorotase NP_345636.1 1103083 R 170187 CDS NP_345637.1 15901033 931682 complement(1104364..1104828) 1 NC_003028.3 mutator MutT protein 1104828 931682 SP_1168 Streptococcus pneumoniae TIGR4 mutator MutT protein NP_345637.1 1104364 R 170187 CDS NP_345638.1 15901034 931683 complement(1104838..1105491) 1 NC_003028.3 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 1105491 931683 SP_1169 Streptococcus pneumoniae TIGR4 uracil-DNA glycosylase NP_345638.1 1104838 R 170187 CDS NP_345639.1 15901035 931684 complement(1105629..1106231) 1 NC_003028.3 hypothetical protein 1106231 931684 SP_1170 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345639.1 1105629 R 170187 CDS NP_345640.1 15901036 931685 complement(1106289..1107002) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00702; HAD superfamily hydrolase 1107002 931685 SP_1171 Streptococcus pneumoniae TIGR4 HAD superfamily hydrolase NP_345640.1 1106289 R 170187 CDS NP_345641.1 15901037 931686 complement(1107253..1107372) 1 NC_003028.3 hypothetical protein 1107372 931686 SP_1172 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345641.1 1107253 R 170187 CDS NP_345642.1 15901038 931687 complement(1107462..1107836) 1 NC_003028.3 PTS system mannnose-specific transporter subunit IIA 1107836 931687 SP_1173 Streptococcus pneumoniae TIGR4 PTS system mannnose-specific transporter subunit IIA NP_345642.1 1107462 R 170187 CDS NP_345643.1 15901039 931688 complement(1108258..1110717) 1 NC_003028.3 similar to GP:4249624; identified by sequence similarity; hypothetical protein 1110717 931688 SP_1174 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345643.1 1108258 R 170187 CDS NP_345644.1 15901040 931689 complement(1110875..1113283) 1 NC_003028.3 similar to GP:4249624; identified by sequence similarity; hypothetical protein 1113283 931689 SP_1175 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345644.1 1110875 R 170187 CDS NP_345645.1 15901041 931690 complement(1113578..1115311) 1 NC_003028.3 phosphoenolpyruvate-protein phosphotransferase 1115311 931690 SP_1176 Streptococcus pneumoniae TIGR4 phosphoenolpyruvate-protein phosphotransferase NP_345645.1 1113578 R 170187 CDS NP_345646.1 15901042 931691 complement(1115317..1115580) 1 NC_003028.3 phosphocarrier protein HPr 1115580 931691 SP_1177 Streptococcus pneumoniae TIGR4 phosphocarrier protein HPr NP_345646.1 1115317 R 170187 CDS NP_345647.1 15901043 931692 1115931..1116149 1 NC_003028.3 NrdH-redoxin 1116149 931692 SP_1178 Streptococcus pneumoniae TIGR4 NrdH-redoxin NP_345647.1 1115931 D 170187 CDS NP_345648.1 15901044 931693 1116230..1118389 1 NC_003028.3 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1118389 931693 SP_1179 Streptococcus pneumoniae TIGR4 ribonucleotide-diphosphate reductase subunit alpha NP_345648.1 1116230 D 170187 CDS NP_345649.1 15901045 931694 1118577..1119539 1 NC_003028.3 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1119539 nrdF 931694 nrdF Streptococcus pneumoniae TIGR4 ribonucleotide-diphosphate reductase subunit beta NP_345649.1 1118577 D 170187 CDS NP_345650.1 15901046 931695 complement(1119754..1119852) 1 NC_003028.3 hypothetical protein 1119852 931695 SP_1181 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345650.1 1119754 R 170187 CDS NP_345651.1 15901047 931696 1119827..1120588 1 NC_003028.3 lactose phosphotransferase system repressor 1120588 931696 SP_1182 Streptococcus pneumoniae TIGR4 lactose phosphotransferase system repressor NP_345651.1 1119827 D 170187 CDS NP_345652.1 15901048 931697 complement(1120867..1121031) 1 NC_003028.3 hypothetical protein 1121031 931697 SP_1183 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345652.1 1120867 R 170187 CDS NP_345653.1 15901049 931698 complement(1121169..1122575) 1 NC_003028.3 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 1122575 931698 SP_1184 Streptococcus pneumoniae TIGR4 6-phospho-beta-galactosidase NP_345653.1 1121169 R 170187 CDS NP_345654.1 15901050 931699 complement(1122784..1124475) 1 NC_003028.3 PTS system lactose-specific transporter subunit IIBC 1124475 931699 SP_1185 Streptococcus pneumoniae TIGR4 PTS system lactose-specific transporter subunit IIBC NP_345654.1 1122784 R 170187 CDS NP_345655.1 15901051 931700 complement(1124475..1124792) 1 NC_003028.3 identified by match to PFAM protein family HMM PF02255; PTS system lactose-specific transporter subunit IIA 1124792 931700 SP_1186 Streptococcus pneumoniae TIGR4 PTS system lactose-specific transporter subunit IIA NP_345655.1 1124475 R 170187 CDS NP_345656.1 15901052 931701 complement(1124828..1125664) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00874; transcription antiterminator LacT 1125664 931701 SP_1187 Streptococcus pneumoniae TIGR4 transcription antiterminator LacT NP_345656.1 1124828 R 170187 CDS NP_345657.1 15901053 931702 complement(1125902..1126048) 1 NC_003028.3 hypothetical protein 1126048 931702 SP_1188 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345657.1 1125902 R 170187 CDS NP_345658.1 15901054 931703 complement(1126062..1126604) 1 NC_003028.3 hypothetical protein 1126604 931703 SP_1189 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345658.1 1126062 R 170187 CDS NP_345659.1 15901055 931704 complement(1126937..1127917) 1 NC_003028.3 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase 1127917 931704 SP_1190 Streptococcus pneumoniae TIGR4 tagatose 1,6-diphosphate aldolase NP_345659.1 1126937 R 170187 CDS NP_345660.1 15901056 931705 complement(1127919..1128848) 1 NC_003028.3 catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase 1128848 931705 SP_1191 Streptococcus pneumoniae TIGR4 tagatose-6-phosphate kinase NP_345660.1 1127919 R 170187 CDS NP_345661.1 15901057 931706 complement(1128859..1129374) 1 NC_003028.3 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB 1129374 931706 SP_1192 Streptococcus pneumoniae TIGR4 galactose-6-phosphate isomerase subunit LacB NP_345661.1 1128859 R 170187 CDS NP_345662.1 15901058 931707 complement(1129405..1129830) 1 NC_003028.3 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA 1129830 931707 SP_1193 Streptococcus pneumoniae TIGR4 galactose-6-phosphate isomerase subunit LacA NP_345662.1 1129405 R 170187 CDS NP_345663.1 15901059 931709 complement(1130500..1130889) 1 NC_003028.3 similar to PID:763133; identified by sequence similarity; IS1381 transposase protein B 1130889 931709 SP_1195 Streptococcus pneumoniae TIGR4 IS1381 transposase protein B NP_345663.1 1130500 R 170187 CDS NP_345664.1 15901060 931711 complement(1131313..1131615) 1 NC_003028.3 hypothetical protein 1131615 931711 SP_1197 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345664.1 1131313 R 170187 CDS NP_345665.1 15901061 931712 complement(1131653..1131925) 1 NC_003028.3 hypothetical protein 1131925 931712 SP_1198 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345665.1 1131653 R 170187 CDS NP_345666.1 15901062 931713 complement(1131925..1132041) 1 NC_003028.3 hypothetical protein 1132041 931713 SP_1199 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345666.1 1131925 R 170187 CDS NP_345667.1 15901063 931714 complement(1132584..1134407) 1 NC_003028.3 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 1134407 931714 SP_1200 Streptococcus pneumoniae TIGR4 GTP-binding protein LepA NP_345667.1 1132584 R 170187 CDS NP_345668.1 15901064 931715 complement(1134486..1135214) 1 NC_003028.3 serine/threonine protein phosphatase 1135214 931715 SP_1201 Streptococcus pneumoniae TIGR4 serine/threonine protein phosphatase NP_345668.1 1134486 R 170187 CDS NP_345669.1 15901065 931716 complement(1135216..1136883) 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00634; DNA repair protein RecN 1136883 931716 SP_1202 Streptococcus pneumoniae TIGR4 DNA repair protein RecN NP_345669.1 1135216 R 170187 CDS NP_345670.1 15901066 931717 complement(1136890..1137321) 1 NC_003028.3 transcriptional repressor 1137321 931717 SP_1203 Streptococcus pneumoniae TIGR4 transcriptional repressor NP_345670.1 1136890 R 170187 CDS NP_345671.1 15901067 931718 complement(1137314..1137910) 1 NC_003028.3 similar to GB:M27869 SP:P19672 PID:142449 GB:AL009126; identified by sequence similarity; hemolysin A 1137910 931718 SP_1204 Streptococcus pneumoniae TIGR4 hemolysin A NP_345671.1 1137314 R 170187 CDS NP_345672.1 15901068 931719 complement(1138122..1138997) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00348; geranyltranstransferase 1138997 931719 SP_1205 Streptococcus pneumoniae TIGR4 geranyltranstransferase NP_345672.1 1138122 R 170187 CDS NP_345673.1 15901069 931720 complement(1138994..1139206) 1 NC_003028.3 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 1139206 xseB 931720 xseB Streptococcus pneumoniae TIGR4 exodeoxyribonuclease VII small subunit NP_345673.1 1138994 R 170187 CDS NP_345674.1 15901070 931721 complement(1139184..1140524) 1 NC_003028.3 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 1140524 xseA 931721 xseA Streptococcus pneumoniae TIGR4 exodeoxyribonuclease VII large subunit NP_345674.1 1139184 R 170187 CDS NP_345675.1 15901071 931722 complement(1140652..1141290) 1 NC_003028.3 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1141290 931722 SP_1208 Streptococcus pneumoniae TIGR4 uridine kinase NP_345675.1 1140652 R 170187 CDS NP_345676.1 15901072 931723 1141285..1141401 1 NC_003028.3 hypothetical protein 1141401 931723 SP_1209 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345676.1 1141285 D 170187 CDS NP_345677.1 15901073 931724 complement(1141398..1141565) 1 NC_003028.3 hypothetical protein 1141565 931724 SP_1210 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345677.1 1141398 R 170187 CDS NP_345678.1 15901074 931725 complement(1141697..1141792) 1 NC_003028.3 hypothetical protein 1141792 931725 SP_1211 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345678.1 1141697 R 170187 CDS NP_345679.1 15901075 931726 complement(1141941..1142819) 1 NC_003028.3 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1142819 truB 931726 truB Streptococcus pneumoniae TIGR4 tRNA pseudouridine synthase B NP_345679.1 1141941 R 170187 CDS NP_345680.1 15901076 931727 complement(1142829..1144103) 1 NC_003028.3 similar to GP:6899348; identified by sequence similarity; hypothetical protein 1144103 931727 SP_1213 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345680.1 1142829 R 170187 CDS NP_345681.1 15901077 931729 complement(1145606..1146403) 1 NC_003028.3 FNT family protein 1146403 931729 SP_1215 Streptococcus pneumoniae TIGR4 FNT family protein NP_345681.1 1145606 R 170187 CDS NP_345682.1 15901078 931730 complement(1146372..1146479) 1 NC_003028.3 hypothetical protein 1146479 931730 SP_1216 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345682.1 1146372 R 170187 CDS NP_345683.1 15901079 931731 1146532..1146675 1 NC_003028.3 hypothetical protein 1146675 931731 SP_1217 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345683.1 1146532 D 170187 CDS NP_345684.1 15901080 931732 complement(1146647..1147018) 1 NC_003028.3 hypothetical protein 1147018 931732 SP_1218 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345684.1 1146647 R 170187 CDS NP_345685.1 15901081 931733 complement(1147390..1149858) 1 NC_003028.3 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 1149858 931733 SP_1219 Streptococcus pneumoniae TIGR4 DNA gyrase subunit A NP_345685.1 1147390 R 170187 CDS NP_345686.1 15901082 931734 1150052..1151038 1 NC_003028.3 Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1151038 ldh 931734 ldh Streptococcus pneumoniae TIGR4 L-lactate dehydrogenase NP_345686.1 1150052 D 170187 CDS NP_345687.1 15901083 931735 complement(1151348..1154602) 1 NC_003028.3 similar to GP:4467889; identified by sequence similarity; type II restriction endonuclease 1154602 931735 SP_1221 Streptococcus pneumoniae TIGR4 type II restriction endonuclease NP_345687.1 1151348 R 170187 CDS NP_345688.1 15901084 931736 complement(1154767..1156644) 1 NC_003028.3 similar to GP:4467889; identified by sequence similarity; type II restriction endonuclease 1156644 931736 SP_1222 Streptococcus pneumoniae TIGR4 type II restriction endonuclease NP_345688.1 1154767 R 170187 CDS NP_345689.1 15901085 931737 complement(1156713..1156967) 1 NC_003028.3 hypothetical protein 1156967 931737 SP_1223 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345689.1 1156713 R 170187 CDS NP_345690.1 15901086 931738 complement(1156969..1157271) 1 NC_003028.3 similar to GP:7523564; identified by sequence similarity; hypothetical protein 1157271 931738 SP_1224 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345690.1 1156969 R 170187 CDS NP_345691.1 15901087 931739 complement(1157302..1158111) 1 NC_003028.3 vicX protein 1158111 931739 SP_1225 Streptococcus pneumoniae TIGR4 vicX protein NP_345691.1 1157302 R 170187 CDS NP_345692.1 15901088 931740 complement(1158113..1159462) 1 NC_003028.3 sensory box sensor histidine kinase 1159462 931740 SP_1226 Streptococcus pneumoniae TIGR4 sensory box sensor histidine kinase NP_345692.1 1158113 R 170187 CDS NP_345693.1 15901089 931741 complement(1159455..1160159) 1 NC_003028.3 DNA-binding response regulator 1160159 931741 SP_1227 Streptococcus pneumoniae TIGR4 DNA-binding response regulator NP_345693.1 1159455 R 170187 CDS NP_345694.1 15901090 931742 complement(1160215..1161360) 1 NC_003028.3 A/G-specific adenine glycosylase 1161360 931742 SP_1228 Streptococcus pneumoniae TIGR4 A/G-specific adenine glycosylase NP_345694.1 1160215 R 170187 CDS NP_345695.1 15901091 931743 complement(1161718..1163388) 1 NC_003028.3 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 1163388 931743 SP_1229 Streptococcus pneumoniae TIGR4 formate--tetrahydrofolate ligase NP_345695.1 1161718 R 170187 CDS NP_345696.1 15901092 931744 1163618..1164307 1 NC_003028.3 phosphopantothenate--cysteine ligase 1164307 931744 SP_1230 Streptococcus pneumoniae TIGR4 phosphopantothenate--cysteine ligase NP_345696.1 1163618 D 170187 CDS NP_345697.1 15901093 931745 1164319..1164870 1 NC_003028.3 decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 1164870 931745 SP_1231 Streptococcus pneumoniae TIGR4 phosphopantothenoylcysteine decarboxylase NP_345697.1 1164319 D 170187 CDS NP_345698.1 15901094 931746 1164854..1165417 1 NC_003028.3 hypothetical protein 1165417 931746 SP_1232 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345698.1 1164854 D 170187 CDS NP_345699.1 15901095 931747 1165645..1166226 1 NC_003028.3 hypothetical protein 1166226 931747 SP_1233 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345699.1 1165645 D 170187 CDS NP_345700.1 15901096 931748 1166238..1166753 1 NC_003028.3 similar to GB:AE000512; identified by sequence similarity; biotin repressor family transcriptional regulator 1166753 931748 SP_1234 Streptococcus pneumoniae TIGR4 biotin repressor family transcriptional regulator NP_345700.1 1166238 D 170187 CDS NP_345701.1 15901097 931749 complement(1166750..1167217) 1 NC_003028.3 MutT/nudix family protein 1167217 931749 SP_1235 Streptococcus pneumoniae TIGR4 MutT/nudix family protein NP_345701.1 1166750 R 170187 CDS NP_345702.1 15901098 931750 complement(1167286..1167774) 1 NC_003028.3 acetyltransferase 1167774 931750 SP_1236 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345702.1 1167286 R 170187 CDS NP_345703.1 15901099 931751 complement(1167740..1168303) 1 NC_003028.3 acetyltransferase 1168303 931751 SP_1237 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345703.1 1167740 R 170187 CDS NP_345704.1 15901100 931752 complement(1168313..1170301) 1 NC_003028.3 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1170301 931752 SP_1238 Streptococcus pneumoniae TIGR4 excinuclease ABC subunit B NP_345704.1 1168313 R 170187 CDS NP_345705.1 15901101 931753 complement(1170378..1171331) 1 NC_003028.3 hypothetical protein 1171331 931753 SP_1240 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345705.1 1170378 R 170187 CDS NP_345706.1 15901102 931754 1171501..1173666 1 NC_003028.3 amino acid ABC transporter amino acid-binding protein/permease 1173666 931754 SP_1241 Streptococcus pneumoniae TIGR4 amino acid ABC transporter amino acid-binding protein/permease NP_345706.1 1171501 D 170187 CDS NP_345707.1 15901103 931755 1173666..1174406 1 NC_003028.3 amino acid ABC transporter ATP-binding protein 1174406 931755 SP_1242 Streptococcus pneumoniae TIGR4 amino acid ABC transporter ATP-binding protein NP_345707.1 1173666 D 170187 CDS NP_345708.1 15901104 931756 1174555..1176042 1 NC_003028.3 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1176042 931756 SP_1243 Streptococcus pneumoniae TIGR4 glucose-6-phosphate 1-dehydrogenase NP_345708.1 1174555 D 170187 CDS NP_345709.1 15901105 931757 complement(1176088..1177377) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00448; signal recognition particle-docking protein FtsY 1177377 931757 SP_1244 Streptococcus pneumoniae TIGR4 signal recognition particle-docking protein FtsY NP_345709.1 1176088 R 170187 CDS NP_345710.1 15901106 931758 complement(1177381..1178199) 1 NC_003028.3 Cof family protein 1178199 931758 SP_1245 Streptococcus pneumoniae TIGR4 Cof family protein NP_345710.1 1177381 R 170187 CDS NP_345711.1 15901107 931759 complement(1178199..1178993) 1 NC_003028.3 Cof family protein 1178993 931759 SP_1246 Streptococcus pneumoniae TIGR4 Cof family protein NP_345711.1 1178199 R 170187 CDS NP_345712.1 15901108 931760 complement(1178990..1182529) 1 NC_003028.3 hypothetical protein 1182529 931760 SP_1247 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345712.1 1178990 R 170187 CDS NP_345713.1 15901109 931761 complement(1182520..1183218) 1 NC_003028.3 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 1183218 rnc 931761 rnc Streptococcus pneumoniae TIGR4 ribonuclease III NP_345713.1 1182520 R 170187 CDS NP_345714.1 15901110 931763 complement(1183536..1184522) 1 NC_003028.3 guanosine 5'-monophosphate oxidoreductase 1184522 931763 SP_1249 Streptococcus pneumoniae TIGR4 guanosine 5'-monophosphate oxidoreductase NP_345714.1 1183536 R 170187 CDS NP_345715.1 15901111 931764 complement(1184697..1186025) 1 NC_003028.3 similar to GP:6967634; identified by sequence similarity; hypothetical protein 1186025 931764 SP_1250 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345715.1 1184697 R 170187 CDS NP_345716.1 15901112 931765 complement(1186000..1187931) 1 NC_003028.3 endonuclease 1187931 931765 SP_1251 Streptococcus pneumoniae TIGR4 endonuclease NP_345716.1 1186000 R 170187 CDS NP_345717.1 15901113 931766 complement(1188095..1188265) 1 NC_003028.3 hypothetical protein 1188265 931766 SP_1252 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345717.1 1188095 R 170187 CDS NP_345718.1 15901114 931767 complement(1188265..1188357) 1 NC_003028.3 hypothetical protein 1188357 931767 SP_1253 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345718.1 1188265 R 170187 CDS NP_345719.1 15901115 931768 complement(1188517..1188660) 1 NC_003028.3 hypothetical protein 1188660 931768 SP_1254 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345719.1 1188517 R 170187 CDS NP_345720.1 15901116 931769 complement(1188879..1189238) 1 NC_003028.3 hypothetical protein 1189238 931769 SP_1255 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345720.1 1188879 R 170187 CDS NP_345721.1 15901117 931770 complement(1189242..1189511) 1 NC_003028.3 hypothetical protein 1189511 931770 SP_1256 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345721.1 1189242 R 170187 CDS NP_345722.1 15901118 931772 complement(1190557..1191651) 1 NC_003028.3 2-isopropylmalate synthase 1191651 931772 SP_1258 Streptococcus pneumoniae TIGR4 2-isopropylmalate synthase NP_345722.1 1190557 R 170187 CDS NP_345723.1 15901119 931773 complement(1191670..1192005) 1 NC_003028.3 hypothetical protein 1192005 931773 SP_1259 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345723.1 1191670 R 170187 CDS NP_345724.1 15901120 931774 complement(1192370..1193002) 1 NC_003028.3 similar to GP:1736520; identified by sequence similarity; copper homeostasis protein CutC 1193002 931774 SP_1260 Streptococcus pneumoniae TIGR4 copper homeostasis protein CutC NP_345724.1 1192370 R 170187 CDS NP_345725.1 15901121 931775 complement(1193095..1193454) 1 NC_003028.3 hypothetical protein 1193454 931775 SP_1261 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345725.1 1193095 R 170187 CDS NP_345726.1 15901122 931776 1193814..1195070 1 NC_003028.3 IS1167, transposase 1195070 931776 SP_1262 Streptococcus pneumoniae TIGR4 IS1167, transposase NP_345726.1 1193814 D 170187 CDS NP_345727.1 15901123 931777 complement(1195085..1197184) 1 NC_003028.3 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1197184 931777 SP_1263 Streptococcus pneumoniae TIGR4 DNA topoisomerase I NP_345727.1 1195085 R 170187 CDS NP_345728.1 15901124 931778 complement(1197351..1198394) 1 NC_003028.3 hypothetical protein 1198394 931778 SP_1264 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345728.1 1197351 R 170187 CDS NP_345729.1 15901125 931779 complement(1198653..1198772) 1 NC_003028.3 hypothetical protein 1198772 931779 SP_1265 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345729.1 1198653 R 170187 CDS NP_345730.1 15901126 931780 complement(1199284..1200144) 1 NC_003028.3 DNA processing protein DprA 1200144 931780 SP_1266 Streptococcus pneumoniae TIGR4 DNA processing protein DprA NP_345730.1 1199284 R 170187 CDS NP_345731.1 15901127 931781 complement(1200228..1200917) 1 NC_003028.3 licC protein 1200917 931781 SP_1267 Streptococcus pneumoniae TIGR4 licC protein NP_345731.1 1200228 R 170187 CDS NP_345732.1 15901128 931782 complement(1200929..1201807) 1 NC_003028.3 licB protein 1201807 931782 SP_1268 Streptococcus pneumoniae TIGR4 licB protein NP_345732.1 1200929 R 170187 CDS NP_345733.1 15901129 931783 complement(1201797..1202585) 1 NC_003028.3 choline kinase 1202585 931783 SP_1269 Streptococcus pneumoniae TIGR4 choline kinase NP_345733.1 1201797 R 170187 CDS NP_345734.1 15901130 931784 complement(1202683..1203705) 1 NC_003028.3 zinc-containing alcohol dehydrogenase 1203705 931784 SP_1270 Streptococcus pneumoniae TIGR4 zinc-containing alcohol dehydrogenase NP_345734.1 1202683 R 170187 CDS NP_345735.1 15901131 931785 complement(1203710..1204417) 1 NC_003028.3 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1204417 ispD 931785 ispD Streptococcus pneumoniae TIGR4 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NP_345735.1 1203710 R 170187 CDS NP_345736.1 15901132 931786 1204753..1206240 1 NC_003028.3 polysaccharide biosynthesis protein 1206240 931786 SP_1272 Streptococcus pneumoniae TIGR4 polysaccharide biosynthesis protein NP_345736.1 1204753 D 170187 CDS NP_345737.1 15901133 931787 1206250..1207053 1 NC_003028.3 similar to GP:5001692; identified by sequence similarity; licD1 protein 1207053 931787 SP_1273 Streptococcus pneumoniae TIGR4 licD1 protein NP_345737.1 1206250 D 170187 CDS NP_345738.1 15901134 931788 1207055..1207864 1 NC_003028.3 similar to GP:5001693; identified by sequence similarity; licD2 protein 1207864 931788 SP_1274 Streptococcus pneumoniae TIGR4 licD2 protein NP_345738.1 1207055 D 170187 CDS NP_345739.1 15901135 931789 complement(1208139..1211315) 1 NC_003028.3 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1211315 carB 931789 carB Streptococcus pneumoniae TIGR4 carbamoyl phosphate synthase large subunit NP_345739.1 1208139 R 170187 CDS NP_345740.1 15901136 931790 complement(1211628..1212707) 1 NC_003028.3 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1212707 931790 SP_1276 Streptococcus pneumoniae TIGR4 carbamoyl phosphate synthase small subunit NP_345740.1 1211628 R 170187 CDS NP_345741.1 15901137 931791 complement(1212757..1213680) 1 NC_003028.3 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 1213680 pyrB 931791 pyrB Streptococcus pneumoniae TIGR4 aspartate carbamoyltransferase NP_345741.1 1212757 R 170187 CDS NP_345742.1 15901138 931792 complement(1213699..1214220) 1 NC_003028.3 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 1214220 931792 SP_1278 Streptococcus pneumoniae TIGR4 bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase NP_345742.1 1213699 R 170187 CDS NP_345743.1 15901139 931793 complement(1214431..1215060) 1 NC_003028.3 endonuclease III 1215060 931793 SP_1279 Streptococcus pneumoniae TIGR4 endonuclease III NP_345743.1 1214431 R 170187 CDS NP_345744.1 15901140 931794 complement(1215060..1215602) 1 NC_003028.3 hypothetical protein 1215602 931794 SP_1280 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345744.1 1215060 R 170187 CDS NP_345745.1 15901141 931795 1215724..1216089 1 NC_003028.3 hypothetical protein 1216089 931795 SP_1281 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345745.1 1215724 D 170187 CDS NP_345746.1 15901142 931796 1216328..1217887 1 NC_003028.3 ABC transporter ATP-binding protein 1217887 931796 SP_1282 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345746.1 1216328 D 170187 CDS NP_345747.1 15901143 931797 complement(1217931..1218830) 1 NC_003028.3 metalloprotease; heat shock protein HtpX 1218830 931797 SP_1283 Streptococcus pneumoniae TIGR4 heat shock protein HtpX NP_345747.1 1217931 R 170187 CDS NP_345748.1 15901144 931798 complement(1218832..1219392) 1 NC_003028.3 similar to PID:1519287; identified by sequence similarity; hypothetical protein 1219392 931798 SP_1284 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345748.1 1218832 R 170187 CDS NP_345749.1 15901145 931799 1219486..1220199 1 NC_003028.3 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1220199 gidB 931799 gidB Streptococcus pneumoniae TIGR4 16S rRNA methyltransferase GidB NP_345749.1 1219486 D 170187 CDS NP_345750.1 15901146 931800 1220466..1221785 1 NC_003028.3 uracil permease 1221785 931800 SP_1286 Streptococcus pneumoniae TIGR4 uracil permease NP_345750.1 1220466 D 170187 CDS NP_345751.1 15901147 931801 complement(1221980..1223551) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00448; signal recognition particle protein 1223551 931801 SP_1287 Streptococcus pneumoniae TIGR4 signal recognition particle protein NP_345751.1 1221980 R 170187 CDS NP_345752.1 15901148 931802 complement(1223563..1223895) 1 NC_003028.3 DNA-binding protein 1223895 931802 SP_1288 Streptococcus pneumoniae TIGR4 DNA-binding protein NP_345752.1 1223563 R 170187 CDS NP_345753.1 15901149 931803 complement(1223986..1224363) 1 NC_003028.3 hypothetical protein 1224363 931803 SP_1289 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345753.1 1223986 R 170187 CDS NP_345754.1 15901150 931804 1224435..1225739 1 NC_003028.3 hypothetical protein 1225739 931804 SP_1290 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345754.1 1224435 D 170187 CDS NP_345755.1 15901151 931805 1225752..1226558 1 NC_003028.3 Cof family protein 1226558 931805 SP_1291 Streptococcus pneumoniae TIGR4 Cof family protein NP_345755.1 1225752 D 170187 CDS NP_345756.1 15901152 931806 1226601..1227599 1 NC_003028.3 SAP domain-containing protein 1227599 931806 SP_1292 Streptococcus pneumoniae TIGR4 SAP domain-containing protein NP_345756.1 1226601 D 170187 CDS NP_345757.1 15901153 931808 complement(1227880..1228227) 1 NC_003028.3 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1228227 rplS 931808 rplS Streptococcus pneumoniae TIGR4 50S ribosomal protein L19 NP_345757.1 1227880 R 170187 CDS NP_345758.1 15901154 931809 complement(1228346..1228675) 1 NC_003028.3 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1228675 931809 SP_1294 Streptococcus pneumoniae TIGR4 camphor resistance protein CrcB NP_345758.1 1228346 R 170187 CDS NP_345759.1 15901155 931810 complement(1228669..1229043) 1 NC_003028.3 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1229043 931810 SP_1295 Streptococcus pneumoniae TIGR4 camphor resistance protein CrcB NP_345759.1 1228669 R 170187 CDS NP_345760.1 15901156 931811 complement(1229040..1229306) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01817; hypothetical protein 1229306 931811 SP_1296 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345760.1 1229040 R 170187 CDS NP_345761.1 15901157 931812 complement(1229422..1229865) 1 NC_003028.3 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 1229865 931812 SP_1297 Streptococcus pneumoniae TIGR4 flavodoxin NP_345761.1 1229422 R 170187 CDS NP_345762.1 15901158 931813 1229969..1230904 1 NC_003028.3 identified by match to PFAM protein family HMM PF02272; DHH subfamily 1 protein 1230904 931813 SP_1298 Streptococcus pneumoniae TIGR4 DHH subfamily 1 protein NP_345762.1 1229969 D 170187 CDS NP_345763.1 15901159 931814 1231000..1231242 1 NC_003028.3 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1231242 rpmE2 931814 rpmE2 Streptococcus pneumoniae TIGR4 50S ribosomal protein L31 NP_345763.1 1231000 D 170187 CDS NP_345764.1 15901160 931815 complement(1231299..1231517) 1 NC_003028.3 hypothetical protein 1231517 931815 SP_1300 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345764.1 1231299 R 170187 CDS NP_345765.1 15901161 931817 complement(1231825..1232076) 1 NC_003028.3 hypothetical protein 1232076 931817 SP_1302 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345765.1 1231825 R 170187 CDS NP_345766.1 15901162 931818 complement(1232170..1232265) 1 NC_003028.3 hypothetical protein 1232265 931818 SP_1303 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345766.1 1232170 R 170187 CDS NP_345767.1 15901163 931819 complement(1232390..1232491) 1 NC_003028.3 hypothetical protein 1232491 931819 SP_1304 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345767.1 1232390 R 170187 CDS NP_345768.1 15901164 931820 1232501..1232605 1 NC_003028.3 hypothetical protein 1232605 931820 SP_1305 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345768.1 1232501 D 170187 CDS NP_345769.1 15901165 931821 1232602..1233948 1 NC_003028.3 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1233948 931821 SP_1306 Streptococcus pneumoniae TIGR4 glutamate dehydrogenase NP_345769.1 1232602 D 170187 CDS NP_345770.1 15901166 931822 complement(1234454..1234624) 1 NC_003028.3 hypothetical protein 1234624 931822 SP_1307 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345770.1 1234454 R 170187 CDS NP_345771.1 15901167 931825 complement(1235637..1236035) 1 NC_003028.3 similar to PID:763133; identified by sequence similarity; IS1381 transposase protein A 1236035 931825 SP_1310 Streptococcus pneumoniae TIGR4 IS1381 transposase protein A NP_345771.1 1235637 R 170187 CDS NP_345772.1 15901168 931829 complement(1238079..1238318) 1 NC_003028.3 similar to GP:4009479; identified by sequence similarity; IS66 family Orf1 1238318 931829 SP_1314 Streptococcus pneumoniae TIGR4 IS66 family Orf1 NP_345772.1 1238079 R 170187 CDS NP_345773.1 15901169 931830 complement(1238537..1239148) 1 NC_003028.3 produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit D 1239148 931830 SP_1315 Streptococcus pneumoniae TIGR4 V-type ATP synthase subunit D NP_345773.1 1238537 R 170187 CDS NP_345774.1 15901170 931831 complement(1239171..1240556) 1 NC_003028.3 produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit B 1240556 931831 SP_1316 Streptococcus pneumoniae TIGR4 V-type ATP synthase subunit B NP_345774.1 1239171 R 170187 CDS NP_345775.1 15901171 931832 complement(1240557..1242332) 1 NC_003028.3 produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit A 1242332 931832 SP_1317 Streptococcus pneumoniae TIGR4 V-type ATP synthase subunit A NP_345775.1 1240557 R 170187 CDS NP_345776.1 15901172 931833 complement(1242395..1242715) 1 NC_003028.3 produces ATP from ADP in the presence of a proton gradient across the membrane; the F subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit F 1242715 931833 SP_1318 Streptococcus pneumoniae TIGR4 V-type ATP synthase subunit F NP_345776.1 1242395 R 170187 CDS NP_345777.1 15901173 931835 complement(1242705..1243712) 1 NC_003028.3 v-type sodium ATP synthase subunit C 1243712 931835 SP_1319 Streptococcus pneumoniae TIGR4 v-type sodium ATP synthase subunit C NP_345777.1 1242705 R 170187 CDS NP_345778.1 15901174 931836 complement(1243777..1244358) 1 NC_003028.3 v-type sodium ATP synthase subunit E 1244358 931836 SP_1320 Streptococcus pneumoniae TIGR4 v-type sodium ATP synthase subunit E NP_345778.1 1243777 R 170187 CDS NP_345779.1 15901175 931837 complement(1244392..1244868) 1 NC_003028.3 produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits; V-type ATP synthase subunit K 1244868 931837 SP_1321 Streptococcus pneumoniae TIGR4 V-type ATP synthase subunit K NP_345779.1 1244392 R 170187 CDS NP_345780.1 15901176 931838 complement(1244884..1246875) 1 NC_003028.3 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I is part of the membrane proton channel.; V-type ATP synthase subunit I 1246875 931838 SP_1322 Streptococcus pneumoniae TIGR4 V-type ATP synthase subunit I NP_345780.1 1244884 R 170187 CDS NP_345781.1 15901177 931839 complement(1246865..1247188) 1 NC_003028.3 hypothetical protein 1247188 931839 SP_1323 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345781.1 1246865 R 170187 CDS NP_345782.1 15901178 931840 complement(1247213..1248103) 1 NC_003028.3 ROK family protein 1248103 931840 SP_1324 Streptococcus pneumoniae TIGR4 ROK family protein NP_345782.1 1247213 R 170187 CDS NP_345783.1 15901179 931841 complement(1248260..1249399) 1 NC_003028.3 Gfo/Idh/MocA family oxidoreductase 1249399 931841 SP_1325 Streptococcus pneumoniae TIGR4 Gfo/Idh/MocA family oxidoreductase NP_345783.1 1248260 R 170187 CDS NP_345784.1 15901180 931842 complement(1249409..1251631) 1 NC_003028.3 neuraminidase 1251631 931842 SP_1326 Streptococcus pneumoniae TIGR4 neuraminidase NP_345784.1 1249409 R 170187 CDS NP_345785.1 15901181 931843 complement(1251633..1252091) 1 NC_003028.3 hypothetical protein 1252091 931843 SP_1327 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345785.1 1251633 R 170187 CDS NP_345786.1 15901182 931845 complement(1252110..1253651) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00474; sodium:solute symporter family protein 1253651 931845 SP_1328 Streptococcus pneumoniae TIGR4 sodium:solute symporter family protein NP_345786.1 1252110 R 170187 CDS NP_345787.1 15901183 931846 complement(1253679..1254596) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00701; N-acetylneuraminate lyase 1254596 931846 SP_1329 Streptococcus pneumoniae TIGR4 N-acetylneuraminate lyase NP_345787.1 1253679 R 170187 CDS NP_345788.1 15901184 931847 complement(1254621..1255322) 1 NC_003028.3 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 1255322 931847 SP_1330 Streptococcus pneumoniae TIGR4 N-acetylmannosamine-6-phosphate 2-epimerase NP_345788.1 1254621 R 170187 CDS NP_345789.1 15901185 931848 complement(1255327..1256136) 1 NC_003028.3 phosphosugar-binding transcriptional regulator 1256136 931848 SP_1331 Streptococcus pneumoniae TIGR4 phosphosugar-binding transcriptional regulator NP_345789.1 1255327 R 170187 CDS NP_345790.1 15901186 931849 complement(1256535..1257122) 1 NC_003028.3 similar to GB:AL123456; identified by sequence similarity; hypothetical protein 1257122 931849 SP_1332 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345790.1 1256535 R 170187 CDS NP_345791.1 15901187 931850 complement(1257125..1257358) 1 NC_003028.3 hypothetical protein 1257358 931850 SP_1333 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345791.1 1257125 R 170187 CDS NP_345792.1 15901188 931851 complement(1257371..1257751) 1 NC_003028.3 hypothetical protein 1257751 931851 SP_1334 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345792.1 1257371 R 170187 CDS NP_345793.1 15901189 931852 complement(1257909..1258097) 1 NC_003028.3 hypothetical protein 1258097 931852 SP_1335 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345793.1 1257909 R 170187 CDS NP_345794.1 15901190 931853 complement(1258315..1259538) 1 NC_003028.3 type II DNA modification methyltransferase Spn5252IP 1259538 931853 SP_1336 Streptococcus pneumoniae TIGR4 type II DNA modification methyltransferase Spn5252IP NP_345794.1 1258315 R 170187 CDS NP_345795.1 15901191 931854 complement(1259720..1261066) 1 NC_003028.3 similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 1261066 931854 SP_1337 Streptococcus pneumoniae TIGR4 IS1380-Spn1 transposase NP_345795.1 1259720 R 170187 CDS NP_345796.1 15901192 931855 complement(1261328..1261507) 1 NC_003028.3 hypothetical protein 1261507 931855 SP_1338 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345796.1 1261328 R 170187 CDS NP_345797.1 15901193 931856 complement(1261687..1261824) 1 NC_003028.3 hypothetical protein 1261824 931856 SP_1339 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345797.1 1261687 R 170187 CDS NP_345798.1 15901194 931857 complement(1261957..1263276) 1 NC_003028.3 hypothetical protein 1263276 931857 SP_1340 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345798.1 1261957 R 170187 CDS NP_345799.1 15901195 931858 complement(1263279..1264019) 1 NC_003028.3 ABC transporter ATP-binding protein 1264019 931858 SP_1341 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345799.1 1263279 R 170187 CDS NP_345800.1 15901196 931859 complement(1264034..1265641) 1 NC_003028.3 drug efflux ABC transporter ATP-binding protein/permease 1265641 931859 SP_1342 Streptococcus pneumoniae TIGR4 drug efflux ABC transporter ATP-binding protein/permease NP_345800.1 1264034 R 170187 CDS NP_345801.1 15901197 931860 complement(1265638..1267578) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00326; prolyl oligopeptidase 1267578 931860 SP_1343 Streptococcus pneumoniae TIGR4 prolyl oligopeptidase NP_345801.1 1265638 R 170187 CDS NP_345802.1 15901198 931861 complement(1267611..1270220) 1 NC_003028.3 hypothetical protein 1270220 931861 SP_1344 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345802.1 1267611 R 170187 CDS NP_345803.1 15901199 931862 complement(1270383..1270493) 1 NC_003028.3 hypothetical protein 1270493 931862 SP_1345 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345803.1 1270383 R 170187 CDS NP_345804.1 15901200 931863 complement(1270738..1271325) 1 NC_003028.3 hypothetical protein 1271325 931863 SP_1346 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345804.1 1270738 R 170187 CDS NP_345805.1 15901201 931864 complement(1271418..1271561) 1 NC_003028.3 hypothetical protein 1271561 931864 SP_1347 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345805.1 1271418 R 170187 CDS NP_345806.1 15901202 931865 complement(1271574..1271954) 1 NC_003028.3 hypothetical protein 1271954 931865 SP_1348 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345806.1 1271574 R 170187 CDS NP_345807.1 15901203 931866 complement(1272009..1272287) 1 NC_003028.3 hypothetical protein 1272287 931866 SP_1349 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345807.1 1272009 R 170187 CDS NP_345808.1 15901204 931867 complement(1272295..1272549) 1 NC_003028.3 similar to GP:5257160; identified by sequence similarity; hypothetical protein 1272549 931867 SP_1350 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345808.1 1272295 R 170187 CDS NP_345809.1 15901205 931868 complement(1272549..1272656) 1 NC_003028.3 hypothetical protein 1272656 931868 SP_1351 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345809.1 1272549 R 170187 CDS NP_345810.1 15901206 931869 complement(1272838..1274184) 1 NC_003028.3 similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 1274184 931869 SP_1352 Streptococcus pneumoniae TIGR4 IS1380-Spn1 transposase NP_345810.1 1272838 R 170187 CDS NP_345811.1 15901207 931870 complement(1274488..1274595) 1 NC_003028.3 hypothetical protein 1274595 931870 SP_1353 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345811.1 1274488 R 170187 CDS NP_345812.1 15901208 929737 complement(1274614..1274982) 1 NC_003028.3 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1274982 rplL 929737 rplL Streptococcus pneumoniae TIGR4 50S ribosomal protein L7/L12 NP_345812.1 1274614 R 170187 CDS NP_345813.1 15901209 931471 complement(1275058..1275558) 1 NC_003028.3 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1275558 rplJ 931471 rplJ Streptococcus pneumoniae TIGR4 50S ribosomal protein L10 NP_345813.1 1275058 R 170187 CDS NP_345814.3 255964978 929816 complement(1275807..1277066) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01685; chlorohydrolase 1277066 929816 SP_1356 Streptococcus pneumoniae TIGR4 chlorohydrolase NP_345814.3 1275807 R 170187 CDS NP_345815.1 15901211 931878 complement(1277458..1279248) 1 NC_003028.3 ABC transporter ATP-binding protein/permease 1279248 931878 SP_1357 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein/permease NP_345815.1 1277458 R 170187 CDS NP_345816.1 15901212 930077 complement(1279211..1280935) 1 NC_003028.3 ABC transporter ATP-binding protein/permease 1280935 930077 SP_1358 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein/permease NP_345816.1 1279211 R 170187 CDS NP_345817.1 15901213 931912 complement(1280993..1281931) 1 NC_003028.3 this fusion consists of methionine sulfoxide A reductase at the N-terminus and B at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion; bifunctional methionine sulfoxide reductase A/B 1281931 931912 SP_1359 Streptococcus pneumoniae TIGR4 bifunctional methionine sulfoxide reductase A/B NP_345817.1 1280993 R 170187 CDS NP_345818.1 15901214 931412 complement(1282226..1283095) 1 NC_003028.3 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1283095 931412 SP_1360 Streptococcus pneumoniae TIGR4 homoserine kinase NP_345818.1 1282226 R 170187 CDS NP_345819.1 15901215 931415 complement(1283097..1284383) 1 NC_003028.3 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1284383 931415 SP_1361 Streptococcus pneumoniae TIGR4 homoserine dehydrogenase NP_345819.1 1283097 R 170187 CDS NP_345820.1 15901216 931453 complement(1284534..1285271) 1 NC_003028.3 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein 1285271 931453 SP_1362 Streptococcus pneumoniae TIGR4 adaptor protein NP_345820.1 1284534 R 170187 CDS NP_345821.1 15901217 931472 complement(1285471..1286505) 1 NC_003028.3 similar to GB:AL009126; identified by sequence similarity; hypothetical protein 1286505 931472 SP_1363 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345821.1 1285471 R 170187 CDS NP_345822.1 15901218 931470 complement(1286534..1287967) 1 NC_003028.3 hypothetical protein 1287967 931470 SP_1364 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345822.1 1286534 R 170187 CDS NP_345823.1 15901219 931469 complement(1287983..1288969) 1 NC_003028.3 glycosyl transferase family protein 1288969 931469 SP_1365 Streptococcus pneumoniae TIGR4 glycosyl transferase family protein NP_345823.1 1287983 R 170187 CDS NP_345824.1 15901220 931468 complement(1288971..1290074) 1 NC_003028.3 group 1 glycosyl transferase 1290074 931468 SP_1366 Streptococcus pneumoniae TIGR4 group 1 glycosyl transferase NP_345824.1 1288971 R 170187 CDS NP_345825.1 15901221 931467 complement(1290064..1290909) 1 NC_003028.3 similar to GB:L42023 PID:1007735 PID:1221686 PID:1205775 PID:1574382; identified by sequence similarity; licD3 protein 1290909 931467 SP_1367 Streptococcus pneumoniae TIGR4 licD3 protein NP_345825.1 1290064 R 170187 CDS NP_345826.1 15901222 931466 complement(1291188..1292462) 1 NC_003028.3 psr protein 1292462 931466 SP_1368 Streptococcus pneumoniae TIGR4 psr protein NP_345826.1 1291188 R 170187 CDS NP_345827.1 15901223 931465 complement(1292459..1293307) 1 NC_003028.3 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 1293307 931465 SP_1369 Streptococcus pneumoniae TIGR4 prephenate dehydratase NP_345827.1 1292459 R 170187 CDS NP_345828.1 15901224 931464 complement(1293304..1293780) 1 NC_003028.3 shikimate kinase 1293780 931464 SP_1370 Streptococcus pneumoniae TIGR4 shikimate kinase NP_345828.1 1293304 R 170187 CDS NP_345829.1 15901225 931459 complement(1293773..1295056) 1 NC_003028.3 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1295056 931459 SP_1371 Streptococcus pneumoniae TIGR4 3-phosphoshikimate 1-carboxyvinyltransferase NP_345829.1 1293773 R 170187 CDS NP_345830.1 15901226 931460 complement(1295148..1295486) 1 NC_003028.3 hypothetical protein 1295486 931460 SP_1372 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345830.1 1295148 R 170187 CDS NP_345831.1 15901227 931462 complement(1295497..1296600) 1 NC_003028.3 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 1296600 931462 SP_1373 Streptococcus pneumoniae TIGR4 prephenate dehydrogenase NP_345831.1 1295497 R 170187 CDS NP_345832.1 15901228 931463 complement(1296610..1297776) 1 NC_003028.3 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1297776 931463 SP_1374 Streptococcus pneumoniae TIGR4 chorismate synthase NP_345832.1 1296610 R 170187 CDS NP_345833.1 15901229 931458 complement(1297786..1298853) 1 NC_003028.3 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1298853 aroB 931458 aroB Streptococcus pneumoniae TIGR4 3-dehydroquinate synthase NP_345833.1 1297786 R 170187 CDS NP_345834.1 15901230 931461 complement(1298872..1299726) 1 NC_003028.3 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1299726 aroE 931461 aroE Streptococcus pneumoniae TIGR4 shikimate 5-dehydrogenase NP_345834.1 1298872 R 170187 CDS NP_345835.1 15901231 931457 complement(1299716..1300393) 1 NC_003028.3 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1300393 aroD 931457 aroD Streptococcus pneumoniae TIGR4 3-dehydroquinate dehydratase NP_345835.1 1299716 R 170187 CDS NP_345836.1 15901232 931450 complement(1300390..1301562) 1 NC_003028.3 hypothetical protein 1301562 931450 SP_1378 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345836.1 1300390 R 170187 CDS NP_345837.1 15901233 931451 1301604..1301750 1 NC_003028.3 hypothetical protein 1301750 931451 SP_1379 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345837.1 1301604 D 170187 CDS NP_345838.1 15901234 931452 complement(1302240..1303901) 1 NC_003028.3 hypothetical protein 1303901 931452 SP_1380 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345838.1 1302240 R 170187 CDS NP_345839.1 15901235 931454 complement(1303855..1304604) 1 NC_003028.3 ABC transporter ATP-binding protein 1304604 931454 SP_1381 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345839.1 1303855 R 170187 CDS NP_345840.1 15901236 931456 1304783..1306237 1 NC_003028.3 converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 1306237 931456 SP_1382 Streptococcus pneumoniae TIGR4 alpha-amylase NP_345840.1 1304783 D 170187 CDS NP_345841.1 15901237 931455 complement(1306327..1308945) 1 NC_003028.3 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1308945 alaS 931455 alaS Streptococcus pneumoniae TIGR4 alanyl-tRNA synthetase NP_345841.1 1306327 R 170187 CDS NP_345842.1 15901238 931484 complement(1308967..1309464) 1 NC_003028.3 hypothetical protein 1309464 931484 SP_1384 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345842.1 1308967 R 170187 CDS NP_345843.1 15901239 931485 complement(1309727..1309966) 1 NC_003028.3 hypothetical protein 1309966 931485 SP_1385 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345843.1 1309727 R 170187 CDS NP_345844.1 15901240 931448 complement(1310219..1311289) 1 NC_003028.3 spermidine/putrescine ABC transporter spermidine/putrescine-binding protein 1311289 931448 SP_1386 Streptococcus pneumoniae TIGR4 spermidine/putrescine ABC transporter spermidine/putrescine-binding protein NP_345844.1 1310219 R 170187 CDS NP_345845.1 15901241 931449 complement(1311286..1312059) 1 NC_003028.3 spermidine/putrescine ABC transporter permease 1312059 931449 SP_1387 Streptococcus pneumoniae TIGR4 spermidine/putrescine ABC transporter permease NP_345845.1 1311286 R 170187 CDS NP_345846.1 15901242 931436 complement(1312056..1312883) 1 NC_003028.3 spermidine/putrescine ABC transporter permease 1312883 931436 SP_1388 Streptococcus pneumoniae TIGR4 spermidine/putrescine ABC transporter permease NP_345846.1 1312056 R 170187 CDS NP_345847.1 15901243 931437 complement(1312843..1314000) 1 NC_003028.3 spermidine/putrescine ABC transporter ATP-binding protein 1314000 931437 SP_1389 Streptococcus pneumoniae TIGR4 spermidine/putrescine ABC transporter ATP-binding protein NP_345847.1 1312843 R 170187 CDS NP_345848.1 15901244 931443 complement(1314059..1315009) 1 NC_003028.3 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 1315009 murB 931443 murB Streptococcus pneumoniae TIGR4 UDP-N-acetylenolpyruvoylglucosamine reductase NP_345848.1 1314059 R 170187 CDS NP_345849.1 15901245 931444 complement(1315121..1315873) 1 NC_003028.3 hypothetical protein 1315873 931444 SP_1391 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345849.1 1315121 R 170187 CDS NP_345850.1 15901246 931445 complement(1315883..1316614) 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR01252; alpha-acetolactate decarboxylase 1316614 931445 SP_1392 Streptococcus pneumoniae TIGR4 alpha-acetolactate decarboxylase NP_345850.1 1315883 R 170187 CDS NP_345851.1 15901247 931447 1316756..1318027 1 NC_003028.3 hypothetical protein 1318027 931447 SP_1393 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345851.1 1316756 D 170187 CDS NP_345852.1 15901248 931446 complement(1318047..1318862) 1 NC_003028.3 amino acid ABC transporter amino acid-binding protein 1318862 931446 SP_1394 Streptococcus pneumoniae TIGR4 amino acid ABC transporter amino acid-binding protein NP_345852.1 1318047 R 170187 CDS NP_345853.1 15901249 931442 complement(1319019..1319672) 1 NC_003028.3 similar to OMNI:NT01EC4457; identified by sequence similarity; phosphate transport system regulatory protein PhoU 1319672 931442 SP_1395 Streptococcus pneumoniae TIGR4 phosphate transport system regulatory protein PhoU NP_345853.1 1319019 R 170187 CDS NP_345854.1 15901250 931441 complement(1319684..1320442) 1 NC_003028.3 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1320442 931441 SP_1396 Streptococcus pneumoniae TIGR4 phosphate transporter ATP-binding protein NP_345854.1 1319684 R 170187 CDS NP_345855.1 15901251 931440 complement(1320455..1321258) 1 NC_003028.3 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1321258 931440 SP_1397 Streptococcus pneumoniae TIGR4 phosphate transporter ATP-binding protein NP_345855.1 1320455 R 170187 CDS NP_345856.1 15901252 931439 complement(1321269..1322153) 1 NC_003028.3 phosphate ABC transporter permease 1322153 931439 SP_1398 Streptococcus pneumoniae TIGR4 phosphate ABC transporter permease NP_345856.1 1321269 R 170187 CDS NP_345857.1 15901253 931438 complement(1322143..1323060) 1 NC_003028.3 phosphate ABC transporter permease 1323060 931438 SP_1399 Streptococcus pneumoniae TIGR4 phosphate ABC transporter permease NP_345857.1 1322143 R 170187 CDS NP_345858.1 15901254 931432 complement(1323060..1323938) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01449; phosphate ABC transporter substrate-binding protein 1323938 931432 SP_1400 Streptococcus pneumoniae TIGR4 phosphate ABC transporter substrate-binding protein NP_345858.1 1323060 R 170187 CDS NP_345859.1 15901255 931433 1324090..1324281 1 NC_003028.3 hypothetical protein 1324281 931433 SP_1401 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345859.1 1324090 D 170187 CDS NP_345860.1 15901256 931435 complement(1324512..1325816) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01189; NOL1/NOP2/sun family protein 1325816 931435 SP_1402 Streptococcus pneumoniae TIGR4 NOL1/NOP2/sun family protein NP_345860.1 1324512 R 170187 CDS NP_345861.1 15901257 931430 complement(1325817..1326590) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00459; inositol monophosphatase 1326590 931430 SP_1403 Streptococcus pneumoniae TIGR4 inositol monophosphatase NP_345861.1 1325817 R 170187 CDS NP_345862.1 15901258 931434 complement(1326580..1326858) 1 NC_003028.3 hypothetical protein 1326858 931434 SP_1404 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345862.1 1326580 R 170187 CDS NP_345863.1 15901259 931424 complement(1326858..1327259) 1 NC_003028.3 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 1327259 spxA 931424 spxA Streptococcus pneumoniae TIGR4 transcriptional regulator Spx NP_345863.1 1326858 R 170187 CDS NP_345864.1 15901260 931427 complement(1327469..1328086) 1 NC_003028.3 hypothetical protein 1328086 931427 SP_1406 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345864.1 1327469 R 170187 CDS NP_345865.1 15901261 931429 complement(1328076..1328849) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00702; HAD superfamily hydrolase 1328849 931429 SP_1407 Streptococcus pneumoniae TIGR4 HAD superfamily hydrolase NP_345865.1 1328076 R 170187 CDS NP_345866.1 15901262 931428 complement(1328860..1329597) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01643; acyl-ACP thioesterase 1329597 931428 SP_1408 Streptococcus pneumoniae TIGR4 acyl-ACP thioesterase NP_345866.1 1328860 R 170187 CDS NP_345867.1 15901263 931425 complement(1329602..1330732) 1 NC_003028.3 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 1330732 931425 SP_1409 Streptococcus pneumoniae TIGR4 coproporphyrinogen III oxidase NP_345867.1 1329602 R 170187 CDS NP_345868.1 15901264 931423 complement(1330816..1331205) 1 NC_003028.3 hypothetical protein 1331205 931423 SP_1410 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345868.1 1330816 R 170187 CDS NP_345869.1 15901265 931431 complement(1331221..1331604) 1 NC_003028.3 hypothetical protein 1331604 931431 SP_1411 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345869.1 1331221 R 170187 CDS NP_345870.1 15901266 931418 complement(1331605..1332393) 1 NC_003028.3 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1332393 931418 SP_1412 Streptococcus pneumoniae TIGR4 prolipoprotein diacylglyceryl transferase NP_345870.1 1331605 R 170187 CDS NP_345871.1 15901267 931419 complement(1332386..1333324) 1 NC_003028.3 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 1333324 931419 SP_1413 Streptococcus pneumoniae TIGR4 HPr kinase/phosphorylase NP_345871.1 1332386 R 170187 CDS NP_345872.1 15901268 931422 complement(1333451..1333627) 1 NC_003028.3 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1333627 rpsU 931422 rpsU Streptococcus pneumoniae TIGR4 30S ribosomal protein S21 NP_345872.1 1333451 R 170187 CDS NP_345873.1 15901269 931420 complement(1333773..1334474) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01182; glucosamine-6-phosphate isomerase 1334474 931420 SP_1415 Streptococcus pneumoniae TIGR4 glucosamine-6-phosphate isomerase NP_345873.1 1333773 R 170187 CDS NP_345874.1 15901270 931421 1334625..1335653 1 NC_003028.3 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 1335653 queA 931421 queA Streptococcus pneumoniae TIGR4 S-adenosylmethionine--tRNA ribosyltransferase-isomerase NP_345874.1 1334625 D 170187 CDS NP_345875.1 15901271 931473 1338003..1339349 1 NC_003028.3 similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 1339349 931473 SP_1418 Streptococcus pneumoniae TIGR4 IS1380-Spn1 transposase NP_345875.1 1338003 D 170187 CDS NP_345876.1 15901272 931474 complement(1339908..1340459) 1 NC_003028.3 acetyltransferase 1340459 931474 SP_1419 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345876.1 1339908 R 170187 CDS NP_345877.1 15901273 931416 complement(1340809..1341633) 1 NC_003028.3 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1341633 nadE 931416 nadE Streptococcus pneumoniae TIGR4 NAD synthetase NP_345877.1 1340809 R 170187 CDS NP_345878.1 15901274 931414 complement(1341630..1343090) 1 NC_003028.3 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1343090 931414 SP_1421 Streptococcus pneumoniae TIGR4 nicotinate phosphoribosyltransferase NP_345878.1 1341630 R 170187 CDS NP_345879.1 15901275 931405 complement(1343206..1343694) 1 NC_003028.3 hypothetical protein 1343694 931405 SP_1422 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345879.1 1343206 R 170187 CDS NP_345880.1 15901276 931409 complement(1343684..1343923) 1 NC_003028.3 transcriptional repressor 1343923 931409 SP_1423 Streptococcus pneumoniae TIGR4 transcriptional repressor NP_345880.1 1343684 R 170187 CDS NP_345881.1 15901277 931410 complement(1344357..1344758) 1 NC_003028.3 hypothetical protein 1344758 931410 SP_1424 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345881.1 1344357 R 170187 CDS NP_345882.1 15901278 931413 complement(1344774..1344908) 1 NC_003028.3 hypothetical protein 1344908 931413 SP_1425 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345882.1 1344774 R 170187 CDS NP_345883.1 15901279 931388 complement(1344918..1345652) 1 NC_003028.3 ABC transporter ATP-binding protein 1345652 931388 SP_1426 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345883.1 1344918 R 170187 CDS NP_345884.1 15901280 930073 complement(1345987..1346712) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01136; U32 family peptidase 1346712 930073 SP_1427 Streptococcus pneumoniae TIGR4 U32 family peptidase NP_345884.1 1345987 R 170187 CDS NP_345885.1 15901281 931910 complement(1346961..1347272) 1 NC_003028.3 hypothetical protein 1347272 931910 SP_1428 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345885.1 1346961 R 170187 CDS NP_345886.1 15901282 931399 complement(1347287..1348573) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01136; U32 family peptidase 1348573 931399 SP_1429 Streptococcus pneumoniae TIGR4 U32 family peptidase NP_345886.1 1347287 R 170187 CDS NP_345887.1 15901283 931411 1349751..1350941 1 NC_003028.3 type II DNA modification methyltransferase 1350941 931411 SP_1431 Streptococcus pneumoniae TIGR4 type II DNA modification methyltransferase NP_345887.1 1349751 D 170187 CDS NP_345888.1 15901284 931408 1351183..1351329 1 NC_003028.3 hypothetical protein 1351329 931408 SP_1432 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345888.1 1351183 D 170187 CDS NP_345889.1 15901285 931406 complement(1351451..1352443) 1 NC_003028.3 AraC family transcriptional regulator 1352443 931406 SP_1433 Streptococcus pneumoniae TIGR4 AraC family transcriptional regulator NP_345889.1 1351451 R 170187 CDS NP_345890.1 15901286 931407 1352597..1354357 1 NC_003028.3 ABC transporter ATP-binding protein/permease 1354357 931407 SP_1434 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein/permease NP_345890.1 1352597 D 170187 CDS NP_345891.1 15901287 931404 1354317..1356062 1 NC_003028.3 ABC transporter ATP-binding protein 1356062 931404 SP_1435 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345891.1 1354317 D 170187 CDS NP_345892.1 15901288 931402 1356073..1356702 1 NC_003028.3 hypothetical protein 1356702 931402 SP_1436 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345892.1 1356073 D 170187 CDS NP_345893.1 15901289 931395 1356717..1357160 1 NC_003028.3 similar to GB:AE000512; identified by sequence similarity; hypothetical protein 1357160 931395 SP_1437 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345893.1 1356717 D 170187 CDS NP_345894.1 15901290 931396 1357148..1358272 1 NC_003028.3 ABC transporter ATP-binding protein 1358272 931396 SP_1438 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_345894.1 1357148 D 170187 CDS NP_345895.1 15901291 931397 1358413..1359759 1 NC_003028.3 similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 1359759 931397 SP_1439 Streptococcus pneumoniae TIGR4 IS1380-Spn1 transposase NP_345895.1 1358413 D 170187 CDS NP_345896.1 15901292 931398 complement(1362492..1362842) 1 NC_003028.3 similar to GP:6009406; identified by sequence similarity; IS66 family Orf2 1362842 931398 SP_1442 Streptococcus pneumoniae TIGR4 IS66 family Orf2 NP_345896.1 1362492 R 170187 CDS NP_345897.1 15901293 931389 complement(1362823..1363062) 1 NC_003028.3 This region contains a gene with one or more premature stops or frameshifts, and is not the result of a sequencing artifact; Resembles an IS679 element (IS66 family); IS66 family Orf1 1363062 931389 SP_1443 Streptococcus pneumoniae TIGR4 IS66 family Orf1 NP_345897.1 1362823 R 170187 CDS NP_345898.1 15901294 931390 1363255..1364511 1 NC_003028.3 IS1167, transposase 1364511 931390 SP_1444 Streptococcus pneumoniae TIGR4 IS1167, transposase NP_345898.1 1363255 D 170187 CDS NP_345899.1 15901295 931393 complement(1364734..1366296) 1 NC_003028.3 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1366296 guaA 931393 guaA Streptococcus pneumoniae TIGR4 GMP synthase NP_345899.1 1364734 R 170187 CDS NP_345900.1 15901296 931394 1366429..1367136 1 NC_003028.3 GntR family transcriptional regulator 1367136 931394 SP_1446 Streptococcus pneumoniae TIGR4 GntR family transcriptional regulator NP_345900.1 1366429 D 170187 CDS NP_345901.1 15901297 931392 complement(1367179..1368075) 1 NC_003028.3 hypothetical protein 1368075 931392 SP_1447 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345901.1 1367179 R 170187 CDS NP_345902.1 15901298 931391 complement(1368084..1369019) 1 NC_003028.3 hypothetical protein 1369019 931391 SP_1448 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345902.1 1368084 R 170187 CDS NP_345903.1 15901299 931387 complement(1369016..1369741) 1 NC_003028.3 similar to GP:5001711; identified by sequence similarity; C3-degrading proteinase 1369741 931387 SP_1449 Streptococcus pneumoniae TIGR4 C3-degrading proteinase NP_345903.1 1369016 R 170187 CDS NP_345904.1 15901300 931386 complement(1369825..1370460) 1 NC_003028.3 platelet activating factor 1370460 931386 SP_1450 Streptococcus pneumoniae TIGR4 platelet activating factor NP_345904.1 1369825 R 170187 CDS NP_345905.1 15901301 931385 complement(1370462..1371289) 1 NC_003028.3 Cof family protein 1371289 931385 SP_1451 Streptococcus pneumoniae TIGR4 Cof family protein NP_345905.1 1370462 R 170187 CDS NP_345906.1 15901302 931378 complement(1371311..1371610) 1 NC_003028.3 hypothetical protein 1371610 931378 SP_1452 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345906.1 1371311 R 170187 CDS NP_345907.1 15901303 931380 complement(1371647..1372159) 1 NC_003028.3 similar to GB:M24150 SP:P19579 PID:142633; identified by sequence similarity; hypothetical protein 1372159 931380 SP_1453 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345907.1 1371647 R 170187 CDS NP_345908.1 15901304 931381 complement(1372253..1372375) 1 NC_003028.3 hypothetical protein 1372375 931381 SP_1454 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345908.1 1372253 R 170187 CDS NP_345909.1 15901305 931382 complement(1372518..1372709) 1 NC_003028.3 hypothetical protein 1372709 931382 SP_1455 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345909.1 1372518 R 170187 CDS NP_345910.1 15901306 931384 1372898..1373509 1 NC_003028.3 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1373509 def 931384 def Streptococcus pneumoniae TIGR4 peptide deformylase NP_345910.1 1372898 D 170187 CDS NP_345911.1 15901307 931383 1373554..1374282 1 NC_003028.3 spoU rRNA methylase 1374282 931383 SP_1457 Streptococcus pneumoniae TIGR4 spoU rRNA methylase NP_345911.1 1373554 D 170187 CDS NP_345912.1 15901308 931372 complement(1374321..1375232) 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR01292; thioredoxin reductase 1375232 931372 SP_1458 Streptococcus pneumoniae TIGR4 thioredoxin reductase NP_345912.1 1374321 R 170187 CDS NP_345913.1 15901309 931373 complement(1375298..1375534) 1 NC_003028.3 hypothetical protein 1375534 931373 SP_1459 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345913.1 1375298 R 170187 CDS NP_345914.1 15901310 931376 complement(1375600..1376343) 1 NC_003028.3 amino acid ABC transporter ATP-binding protein 1376343 931376 SP_1460 Streptococcus pneumoniae TIGR4 amino acid ABC transporter ATP-binding protein NP_345914.1 1375600 R 170187 CDS NP_345915.1 15901311 931377 complement(1376343..1377143) 1 NC_003028.3 amino acid ABC transporter permease 1377143 931377 SP_1461 Streptococcus pneumoniae TIGR4 amino acid ABC transporter permease NP_345915.1 1376343 R 170187 CDS NP_345916.1 15901312 929756 complement(1377301..1377657) 1 NC_003028.3 hypothetical protein 1377657 929756 SP_1462 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345916.1 1377301 R 170187 CDS NP_345917.1 15901313 931367 complement(1377651..1378181) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01035; methylated-DNA--protein-cysteine S-methyltransferase 1378181 931367 SP_1463 Streptococcus pneumoniae TIGR4 methylated-DNA--protein-cysteine S-methyltransferase NP_345917.1 1377651 R 170187 CDS NP_345918.1 15901314 931379 complement(1378181..1378675) 1 NC_003028.3 acetyltransferase 1378675 931379 SP_1464 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345918.1 1378181 R 170187 CDS NP_345919.1 15901315 931375 1378810..1379256 1 NC_003028.3 hypothetical protein 1379256 931375 SP_1465 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345919.1 1378810 D 170187 CDS NP_345920.1 15901316 931374 1379253..1379900 1 NC_003028.3 similar to PID:662880 SP:P54176; identified by sequence similarity; hemolysin 1379900 931374 SP_1466 Streptococcus pneumoniae TIGR4 hemolysin NP_345920.1 1379253 D 170187 CDS NP_345921.1 15901317 931371 complement(1379921..1380502) 1 NC_003028.3 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 1380502 931371 SP_1467 Streptococcus pneumoniae TIGR4 glutamine amidotransferase subunit PdxT NP_345921.1 1379921 R 170187 CDS NP_345922.1 15901318 931370 complement(1380503..1381378) 1 NC_003028.3 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 1381378 931370 SP_1468 Streptococcus pneumoniae TIGR4 pyridoxal biosynthesis lyase PdxS NP_345922.1 1380503 R 170187 CDS NP_345923.1 15901319 931369 complement(1381530..1382909) 1 NC_003028.3 NADH oxidase 1382909 931369 SP_1469 Streptococcus pneumoniae TIGR4 NADH oxidase NP_345923.1 1381530 R 170187 CDS NP_345924.1 15901320 931368 1383203..1384126 1 NC_003028.3 similar to PID:1906609; identified by sequence similarity; thiamine biosynthesis protein ApbE 1384126 931368 SP_1470 Streptococcus pneumoniae TIGR4 thiamine biosynthesis protein ApbE NP_345924.1 1383203 D 170187 CDS NP_345925.1 15901321 931361 1384186..1384791 1 NC_003028.3 similar to GB:L10328 SP:P31465 PID:290561 GB:U00096 PID:1790149; identified by sequence similarity; oxidoreductase 1384791 931361 SP_1471 Streptococcus pneumoniae TIGR4 oxidoreductase NP_345925.1 1384186 D 170187 CDS NP_345926.1 15901322 931365 1384810..1386054 1 NC_003028.3 similar to GB:L10328 SP:P31465 PID:290561 GB:U00096 PID:1790149; identified by sequence similarity; oxidoreductase 1386054 931365 SP_1472 Streptococcus pneumoniae TIGR4 oxidoreductase NP_345926.1 1384810 D 170187 CDS NP_345927.1 15901323 931366 complement(1386277..1386534) 1 NC_003028.3 hypothetical protein 1386534 931366 SP_1473 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345927.1 1386277 R 170187 CDS NP_345928.1 15901324 931364 complement(1386576..1388612) 1 NC_003028.3 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 1388612 glyS 931364 glyS Streptococcus pneumoniae TIGR4 glycyl-tRNA synthetase subunit beta NP_345928.1 1386576 R 170187 CDS NP_345929.1 15901325 931363 complement(1388824..1389741) 1 NC_003028.3 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 1389741 glyQ 931363 glyQ Streptococcus pneumoniae TIGR4 glycyl-tRNA synthetase subunit alpha NP_345929.1 1388824 R 170187 CDS NP_345930.1 15901326 931362 complement(1390112..1390501) 1 NC_003028.3 hypothetical protein 1390501 931362 SP_1476 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345930.1 1390112 R 170187 CDS NP_345931.1 15901327 931353 complement(1390483..1390890) 1 NC_003028.3 hypothetical protein 1390890 931353 SP_1477 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345931.1 1390483 R 170187 CDS NP_345932.1 15901328 931354 complement(1391145..1391987) 1 NC_003028.3 aldo/keto reductase 1391987 931354 SP_1478 Streptococcus pneumoniae TIGR4 aldo/keto reductase NP_345932.1 1391145 R 170187 CDS NP_345933.1 15901329 931360 complement(1392101..1393492) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01522; peptidoglycan N-acetylglucosamine deacetylase A 1393492 931360 SP_1479 Streptococcus pneumoniae TIGR4 peptidoglycan N-acetylglucosamine deacetylase A NP_345933.1 1392101 R 170187 CDS NP_345934.1 15901330 931347 complement(1393727..1393972) 1 NC_003028.3 hypothetical protein 1393972 931347 SP_1480 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345934.1 1393727 R 170187 CDS NP_345935.1 15901331 931351 complement(1393997..1394104) 1 NC_003028.3 hypothetical protein 1394104 931351 SP_1481 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345935.1 1393997 R 170187 CDS NP_345936.1 15901332 931358 1394319..1395296 1 NC_003028.3 Gfo/Idh/MocA family oxidoreductase 1395296 931358 SP_1482 Streptococcus pneumoniae TIGR4 Gfo/Idh/MocA family oxidoreductase NP_345936.1 1394319 D 170187 CDS NP_345937.1 15901333 931359 1395293..1396375 1 NC_003028.3 DEAD/DEAH box helicase 1396375 931359 SP_1483 Streptococcus pneumoniae TIGR4 DEAD/DEAH box helicase NP_345937.1 1395293 D 170187 CDS NP_345938.1 15901334 931356 complement(1397026..1397859) 1 NC_003028.3 IS3-Spn1, transposase 1397859 931356 SP_1485 Streptococcus pneumoniae TIGR4 IS3-Spn1, transposase NP_345938.1 1397026 R 170187 CDS NP_345939.1 15901335 931352 complement(1398351..1398689) 1 NC_003028.3 hypothetical protein 1398689 931352 SP_1487 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345939.1 1398351 R 170187 CDS NP_345940.1 15901336 931350 complement(1398812..1398952) 1 NC_003028.3 hypothetical protein 1398952 931350 SP_1488 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345940.1 1398812 R 170187 CDS NP_345941.1 15901337 931349 complement(1399336..1400532) 1 NC_003028.3 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1400532 tuf 931349 tuf Streptococcus pneumoniae TIGR4 elongation factor Tu NP_345941.1 1399336 R 170187 CDS NP_345942.1 15901338 931336 complement(1400739..1400834) 1 NC_003028.3 hypothetical protein 1400834 931336 SP_1490 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345942.1 1400739 R 170187 CDS NP_345943.1 15901339 931341 complement(1401454..1402323) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00230; glycerol uptake facilitator protein 1402323 931341 SP_1491 Streptococcus pneumoniae TIGR4 glycerol uptake facilitator protein NP_345943.1 1401454 R 170187 CDS NP_345944.1 15901340 931342 complement(1402547..1403155) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00746; cell wall surface anchor family protein 1403155 931342 SP_1492 Streptococcus pneumoniae TIGR4 cell wall surface anchor family protein NP_345944.1 1402547 R 170187 CDS NP_345945.1 15901341 931345 complement(1403113..1404225) 1 NC_003028.3 hypothetical protein 1404225 931345 SP_1493 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345945.1 1403113 R 170187 CDS NP_345946.1 15901342 931348 complement(1404330..1404584) 1 NC_003028.3 hypothetical protein 1404584 931348 SP_1494 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345946.1 1404330 R 170187 CDS NP_345947.1 15901343 931478 complement(1404578..1404820) 1 NC_003028.3 hypothetical protein 1404820 931478 SP_1495 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345947.1 1404578 R 170187 CDS NP_345948.1 15901344 931344 complement(1404942..1405241) 1 NC_003028.3 similar to GP:5019553; identified by sequence similarity; transposase, IS630-Spn1 related, Orf2 1405241 931344 SP_1496 Streptococcus pneumoniae TIGR4 transposase, IS630-Spn1 related, Orf2 NP_345948.1 1404942 R 170187 CDS NP_345949.1 15901345 931340 1406020..1407738 1 NC_003028.3 phosphoglucomutase 1407738 931340 SP_1498 Streptococcus pneumoniae TIGR4 phosphoglucomutase NP_345949.1 1406020 D 170187 CDS NP_345950.1 15901346 931339 1407849..1408196 1 NC_003028.3 similar to GP:5929888; identified by sequence similarity; bacterocin transport accessory protein 1408196 931339 SP_1499 Streptococcus pneumoniae TIGR4 bacterocin transport accessory protein NP_345950.1 1407849 D 170187 CDS NP_345951.1 15901347 931338 complement(1408475..1409311) 1 NC_003028.3 amino acid ABC transporter amino acid-binding protein 1409311 931338 SP_1500 Streptococcus pneumoniae TIGR4 amino acid ABC transporter amino acid-binding protein NP_345951.1 1408475 R 170187 CDS NP_345952.1 15901348 931337 complement(1409324..1409953) 1 NC_003028.3 amino acid ABC transporter ATP-binding protein 1409953 931337 SP_1501 Streptococcus pneumoniae TIGR4 amino acid ABC transporter ATP-binding protein NP_345952.1 1409324 R 170187 CDS NP_345953.1 15901349 931331 complement(1409963..1410604) 1 NC_003028.3 amino acid ABC transporter permease 1410604 931331 SP_1502 Streptococcus pneumoniae TIGR4 amino acid ABC transporter permease NP_345953.1 1409963 R 170187 CDS NP_345954.1 15901350 931332 1410910..1412256 1 NC_003028.3 similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 1412256 931332 SP_1503 Streptococcus pneumoniae TIGR4 IS1380-Spn1 transposase NP_345954.1 1410910 D 170187 CDS NP_345955.1 15901351 931334 complement(1412458..1413669) 1 NC_003028.3 hypothetical protein 1413669 931334 SP_1504 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345955.1 1412458 R 170187 CDS NP_345956.1 15901352 931335 complement(1413677..1414843) 1 NC_003028.3 hypothetical protein 1414843 931335 SP_1505 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345956.1 1413677 R 170187 CDS NP_345957.1 15901353 931333 1414987..1416000 1 NC_003028.3 hypothetical protein 1416000 931333 SP_1506 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345957.1 1414987 D 170187 CDS NP_345958.1 15901354 931476 complement(1416045..1416464) 1 NC_003028.3 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 1416464 atpC 931476 atpC Streptococcus pneumoniae TIGR4 ATP synthase F0F1 subunit epsilon NP_345958.1 1416045 R 170187 CDS NP_345959.1 15901355 931477 complement(1416475..1417881) 1 NC_003028.3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 1417881 931477 SP_1508 Streptococcus pneumoniae TIGR4 ATP synthase F0F1 subunit beta NP_345959.1 1416475 R 170187 CDS NP_345960.1 15901356 931325 complement(1417967..1418845) 1 NC_003028.3 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 1418845 931325 SP_1509 Streptococcus pneumoniae TIGR4 ATP synthase F0F1 subunit gamma NP_345960.1 1417967 R 170187 CDS NP_345961.1 15901357 931329 complement(1418861..1420366) 1 NC_003028.3 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 1420366 931329 SP_1510 Streptococcus pneumoniae TIGR4 ATP synthase F0F1 subunit alpha NP_345961.1 1418861 R 170187 CDS NP_345962.1 15901358 931327 complement(1420381..1420917) 1 NC_003028.3 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 1420917 931327 SP_1511 Streptococcus pneumoniae TIGR4 ATP synthase F0F1 subunit delta NP_345962.1 1420381 R 170187 CDS NP_345963.1 15901359 931330 complement(1420917..1421411) 1 NC_003028.3 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 1421411 931330 SP_1512 Streptococcus pneumoniae TIGR4 ATP synthase F0F1 subunit B NP_345963.1 1420917 R 170187 CDS NP_345964.1 15901360 931328 complement(1421425..1422141) 1 NC_003028.3 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 1422141 931328 SP_1513 Streptococcus pneumoniae TIGR4 ATP synthase F0F1 subunit A NP_345964.1 1421425 R 170187 CDS NP_345965.1 15901361 931326 complement(1422176..1422376) 1 NC_003028.3 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 1422376 931326 SP_1514 Streptococcus pneumoniae TIGR4 ATP synthase F0F1 subunit C NP_345965.1 1422176 R 170187 CDS NP_345966.1 15901362 931322 complement(1423902..1424330) 1 NC_003028.3 acetyltransferase 1424330 931322 SP_1516 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345966.1 1423902 R 170187 CDS NP_345967.1 15901363 931316 complement(1424808..1425290) 1 NC_003028.3 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1425290 greA 931316 greA Streptococcus pneumoniae TIGR4 transcription elongation factor GreA NP_345967.1 1424808 R 170187 CDS NP_345968.1 15901364 931319 complement(1425361..1427016) 1 NC_003028.3 hypothetical protein 1427016 931319 SP_1518 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345968.1 1425361 R 170187 CDS NP_345969.1 15901365 931320 complement(1427097..1427591) 1 NC_003028.3 acetyltransferase 1427591 931320 SP_1519 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345969.1 1427097 R 170187 CDS NP_345970.1 15901366 931318 complement(1427588..1428052) 1 NC_003028.3 acetyltransferase 1428052 931318 SP_1520 Streptococcus pneumoniae TIGR4 acetyltransferase NP_345970.1 1427588 R 170187 CDS NP_345971.1 15901367 931317 complement(1428062..1429396) 1 NC_003028.3 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1429396 murC 931317 murC Streptococcus pneumoniae TIGR4 UDP-N-acetylmuramate--L-alanine ligase NP_345971.1 1428062 R 170187 CDS NP_345972.1 15901368 931315 complement(1429407..1430024) 1 NC_003028.3 similar to SP:Q09202 PID:643097; identified by sequence similarity; hypothetical protein 1430024 931315 SP_1522 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345972.1 1429407 R 170187 CDS NP_345973.1 15901369 931313 complement(1430072..1433170) 1 NC_003028.3 Snf2 family protein 1433170 931313 SP_1523 Streptococcus pneumoniae TIGR4 Snf2 family protein NP_345973.1 1430072 R 170187 CDS NP_345974.1 15901370 931312 complement(1433263..1434429) 1 NC_003028.3 class II aminotransferase 1434429 931312 SP_1524 Streptococcus pneumoniae TIGR4 class II aminotransferase NP_345974.1 1433263 R 170187 CDS NP_345975.1 15901371 931311 complement(1434437..1435531) 1 NC_003028.3 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 1435531 931311 SP_1525 Streptococcus pneumoniae TIGR4 cystathionine gamma-synthase NP_345975.1 1434437 R 170187 CDS NP_345976.1 15901372 931305 complement(1437536..1439494) 1 NC_003028.3 oligopeptide ABC transporter oligopeptide-binding protein AliB 1439494 931305 SP_1527 Streptococcus pneumoniae TIGR4 oligopeptide ABC transporter oligopeptide-binding protein AliB NP_345976.1 1437536 R 170187 CDS NP_345977.1 15901373 931306 complement(1439481..1439576) 1 NC_003028.3 hypothetical protein 1439576 931306 SP_1528 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345977.1 1439481 R 170187 CDS NP_345978.1 15901374 931308 complement(1439697..1441286) 1 NC_003028.3 polysaccharide biosynthesis protein 1441286 931308 SP_1529 Streptococcus pneumoniae TIGR4 polysaccharide biosynthesis protein NP_345978.1 1439697 R 170187 CDS NP_345979.1 15901375 931309 1441425..1442870 1 NC_003028.3 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1442870 murE 931309 murE Streptococcus pneumoniae TIGR4 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase NP_345979.1 1441425 D 170187 CDS NP_345980.1 15901376 931307 complement(1442913..1443110) 1 NC_003028.3 hypothetical protein 1443110 931307 SP_1531 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345980.1 1442913 R 170187 CDS NP_345981.1 15901377 931303 complement(1443844..1444356) 1 NC_003028.3 similar to PID:1216309; identified by sequence similarity; hypothetical protein 1444356 931303 SP_1533 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345981.1 1443844 R 170187 CDS NP_345982.1 15901378 931304 complement(1444442..1445377) 1 NC_003028.3 catalyzes the hydrolysis of pyrophosphate to phosphate; manganese-dependent inorganic pyrophosphatase 1445377 931304 SP_1534 Streptococcus pneumoniae TIGR4 manganese-dependent inorganic pyrophosphatase NP_345982.1 1444442 R 170187 CDS NP_345983.1 15901379 931300 complement(1445448..1445747) 1 NC_003028.3 hypothetical protein 1445747 931300 SP_1535 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345983.1 1445448 R 170187 CDS NP_345984.1 15901380 931301 complement(1445737..1446486) 1 NC_003028.3 hypothetical protein 1446486 931301 SP_1536 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345984.1 1445737 R 170187 CDS NP_345985.1 15901381 931298 complement(1446540..1446899) 1 NC_003028.3 hypothetical protein 1446899 931298 SP_1537 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345985.1 1446540 R 170187 CDS NP_345986.1 15901382 931302 complement(1446901..1448301) 1 NC_003028.3 Cof family protein/peptidyl-prolyl cis-trans isomerase, cyclophilin type 1448301 931302 SP_1538 Streptococcus pneumoniae TIGR4 Cof family protein/peptidyl-prolyl cis-trans isomerase, cyclophilin type NP_345986.1 1446901 R 170187 CDS NP_345987.1 15901383 931284 complement(1448596..1448835) 1 NC_003028.3 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 1448835 rpsR 931284 rpsR Streptococcus pneumoniae TIGR4 30S ribosomal protein S18 NP_345987.1 1448596 R 170187 CDS NP_345988.1 15901384 931283 complement(1448867..1449337) 1 NC_003028.3 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1449337 931283 SP_1540 Streptococcus pneumoniae TIGR4 single-stranded DNA-binding protein NP_345988.1 1448867 R 170187 CDS NP_345989.1 15901385 931287 complement(1449349..1449639) 1 NC_003028.3 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 1449639 rpsF 931287 rpsF Streptococcus pneumoniae TIGR4 30S ribosomal protein S6 NP_345989.1 1449349 R 170187 CDS NP_345990.1 15901386 931292 complement(1449792..1451135) 1 NC_003028.3 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1451135 asnC 931292 asnC Streptococcus pneumoniae TIGR4 asparaginyl-tRNA synthetase NP_345990.1 1449792 R 170187 CDS NP_345991.1 15901387 931296 complement(1451512..1452699) 1 NC_003028.3 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 1452699 931296 SP_1544 Streptococcus pneumoniae TIGR4 aspartate aminotransferase NP_345991.1 1451512 R 170187 CDS NP_345992.1 15901388 931295 complement(1452696..1453127) 1 NC_003028.3 hypothetical protein 1453127 931295 SP_1545 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345992.1 1452696 R 170187 CDS NP_345993.1 15901389 931294 1453424..1454053 1 NC_003028.3 similar to GP:6562870; identified by sequence similarity; hypothetical protein 1454053 931294 SP_1546 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345993.1 1453424 D 170187 CDS NP_345994.1 15901390 931293 complement(1454330..1455058) 1 NC_003028.3 hypothetical protein 1455058 931293 SP_1547 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345994.1 1454330 R 170187 CDS NP_345995.1 15901391 931291 complement(1455368..1456963) 1 NC_003028.3 hypothetical protein 1456963 931291 SP_1548 Streptococcus pneumoniae TIGR4 hypothetical protein NP_345995.1 1455368 R 170187 CDS NP_345996.1 15901392 931290 complement(1456975..1457385) 1 NC_003028.3 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1457385 931290 SP_1549 Streptococcus pneumoniae TIGR4 peptide deformylase NP_345996.1 1456975 R 170187 CDS NP_345997.1 15901393 931289 complement(1457501..1458292) 1 NC_003028.3 YghU; B2989; one of eight glutathione transferase proteins from E. coli; glutathione S-transferase 1458292 931289 SP_1550 Streptococcus pneumoniae TIGR4 glutathione S-transferase NP_345997.1 1457501 R 170187 CDS NP_345998.1 15901394 931288 complement(1458305..1461049) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00690; cation transporter E1-E2 family ATPase 1461049 931288 SP_1551 Streptococcus pneumoniae TIGR4 cation transporter E1-E2 family ATPase NP_345998.1 1458305 R 170187 CDS NP_345999.1 15901395 931190 1461305..1462489 1 NC_003028.3 identified by match to PFAM protein family HMM PF01545; cation efflux family protein 1462489 931190 SP_1552 Streptococcus pneumoniae TIGR4 cation efflux family protein NP_345999.1 1461305 D 170187 CDS NP_346000.1 15901396 931231 complement(1462632..1464503) 1 NC_003028.3 ABC transporter ATP-binding protein 1464503 931231 SP_1553 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_346000.1 1462632 R 170187 CDS NP_346001.1 15901397 931251 complement(1464500..1465684) 1 NC_003028.3 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 1465684 931251 SP_1554 Streptococcus pneumoniae TIGR4 tRNA CCA-pyrophosphorylase NP_346001.1 1464500 R 170187 CDS NP_346002.1 15901398 931285 complement(1465696..1466463) 1 NC_003028.3 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 1466463 931285 SP_1555 Streptococcus pneumoniae TIGR4 dihydrodipicolinate reductase NP_346002.1 1465696 R 170187 CDS NP_346003.1 15901399 931282 complement(1466560..1466697) 1 NC_003028.3 hypothetical protein 1466697 931282 SP_1556 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346003.1 1466560 R 170187 CDS NP_346004.1 15901400 931281 complement(1466740..1467588) 1 NC_003028.3 degV family protein 1467588 931281 SP_1557 Streptococcus pneumoniae TIGR4 degV family protein NP_346004.1 1466740 R 170187 CDS NP_346005.1 15901401 931280 complement(1467590..1467976) 1 NC_003028.3 hypothetical protein 1467976 931280 SP_1558 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346005.1 1467590 R 170187 CDS NP_346006.1 15901402 931273 complement(1468038..1469390) 1 NC_003028.3 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1469390 glmM 931273 glmM Streptococcus pneumoniae TIGR4 phosphoglucosamine mutase NP_346006.1 1468038 R 170187 CDS NP_346007.1 15901403 931274 complement(1469414..1470193) 1 NC_003028.3 hypothetical protein 1470193 931274 SP_1560 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346007.1 1469414 R 170187 CDS NP_346008.1 15901404 931277 complement(1470180..1470950) 1 NC_003028.3 hypothetical protein 1470950 931277 SP_1561 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346008.1 1470180 R 170187 CDS NP_346009.1 15901405 931279 complement(1470955..1471128) 1 NC_003028.3 hypothetical protein 1471128 931279 SP_1562 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346009.1 1470955 R 170187 CDS NP_346010.1 15901406 931278 1471173..1472138 1 NC_003028.3 pyridine nucleotide-disulfide oxidoreductase family protein 1472138 931278 SP_1563 Streptococcus pneumoniae TIGR4 pyridine nucleotide-disulfide oxidoreductase family protein NP_346010.1 1471173 D 170187 CDS NP_346011.1 15901407 931276 complement(1472172..1473083) 1 NC_003028.3 hypothetical protein 1473083 931276 SP_1564 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346011.1 1472172 R 170187 CDS NP_346012.1 15901408 931275 complement(1473080..1474057) 1 NC_003028.3 hypothetical protein 1474057 931275 SP_1565 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346012.1 1473080 R 170187 CDS NP_346013.1 15901409 931272 complement(1474054..1474944) 1 NC_003028.3 hypothetical protein 1474944 931272 SP_1566 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346013.1 1474054 R 170187 CDS NP_346014.1 15901410 931271 complement(1474996..1475376) 1 NC_003028.3 endoribonuclease L-PSP 1475376 931271 SP_1567 Streptococcus pneumoniae TIGR4 endoribonuclease L-PSP NP_346014.1 1474996 R 170187 CDS NP_346015.1 15901411 931264 complement(1475387..1475974) 1 NC_003028.3 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 1475974 engB 931264 engB Streptococcus pneumoniae TIGR4 ribosome biogenesis GTP-binding protein YsxC NP_346015.1 1475387 R 170187 CDS NP_346016.1 15901412 931266 complement(1475983..1477215) 1 NC_003028.3 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1477215 clpX 931266 clpX Streptococcus pneumoniae TIGR4 ATP-dependent protease ATP-binding subunit ClpX NP_346016.1 1475983 R 170187 CDS NP_346017.1 15901413 931269 complement(1477247..1477417) 1 NC_003028.3 hypothetical protein 1477417 931269 SP_1570 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346017.1 1477247 R 170187 CDS NP_346018.1 15901414 931270 complement(1477417..1477923) 1 NC_003028.3 dihydrofolate reductase 1477923 931270 SP_1571 Streptococcus pneumoniae TIGR4 dihydrofolate reductase NP_346018.1 1477417 R 170187 CDS NP_346019.1 15901415 931267 complement(1478053..1478589) 1 NC_003028.3 identified by match to PFAM protein family HMM PF02047; non-heme iron-containing ferritin 1478589 931267 SP_1572 Streptococcus pneumoniae TIGR4 non-heme iron-containing ferritin NP_346019.1 1478053 R 170187 CDS YP_873931.1 118090031 931265 complement(1479067..1480539) 1 NC_003028.3 lysozyme 1480539 lytC 931265 lytC Streptococcus pneumoniae TIGR4 lysozyme YP_873931.1 1479067 R 170187 CDS NP_346020.1 15901416 931262 complement(1480609..1481367) 1 NC_003028.3 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1481367 tpiA 931262 tpiA Streptococcus pneumoniae TIGR4 triosephosphate isomerase NP_346020.1 1480609 R 170187 CDS NP_346021.1 15901417 931256 complement(1481465..1482142) 1 NC_003028.3 hypothetical protein 1482142 931256 SP_1575 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346021.1 1481465 R 170187 CDS NP_346022.1 15901418 931257 complement(1482151..1483095) 1 NC_003028.3 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 1483095 931257 SP_1576 Streptococcus pneumoniae TIGR4 homoserine O-succinyltransferase NP_346022.1 1482151 R 170187 CDS NP_346023.1 15901419 931260 complement(1483277..1483789) 1 NC_003028.3 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1483789 931260 SP_1577 Streptococcus pneumoniae TIGR4 adenine phosphoribosyltransferase NP_346023.1 1483277 R 170187 CDS NP_346024.1 15901420 931261 complement(1483876..1484634) 1 NC_003028.3 hypothetical protein 1484634 931261 SP_1578 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346024.1 1483876 R 170187 CDS NP_346025.1 15901421 931259 complement(1484607..1484729) 1 NC_003028.3 hypothetical protein 1484729 931259 SP_1579 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346025.1 1484607 R 170187 CDS NP_346026.1 15901422 931258 complement(1485135..1486265) 1 NC_003028.3 sugar ABC transporter ATP-binding protein 1486265 931258 SP_1580 Streptococcus pneumoniae TIGR4 sugar ABC transporter ATP-binding protein NP_346026.1 1485135 R 170187 CDS NP_346027.1 15901423 931255 1486366..1486494 1 NC_003028.3 hypothetical protein 1486494 931255 SP_1581 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346027.1 1486366 D 170187 CDS NP_346028.1 15901424 931246 1486593..1487849 1 NC_003028.3 IS1167, transposase 1487849 931246 SP_1582 Streptococcus pneumoniae TIGR4 IS1167, transposase NP_346028.1 1486593 D 170187 CDS NP_346029.1 15901425 931253 complement(1488139..1488714) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00857; isochorismatase 1488714 931253 SP_1583 Streptococcus pneumoniae TIGR4 isochorismatase NP_346029.1 1488139 R 170187 CDS NP_346030.1 15901426 931252 complement(1488714..1489502) 1 NC_003028.3 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY 1489502 931252 SP_1584 Streptococcus pneumoniae TIGR4 transcriptional repressor CodY NP_346030.1 1488714 R 170187 CDS NP_346031.1 15901427 931250 1489654..1489791 1 NC_003028.3 hypothetical protein 1489791 931250 SP_1585 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346031.1 1489654 D 170187 CDS NP_346032.1 15901428 931248 complement(1489766..1491340) 1 NC_003028.3 ATP-dependent RNA helicase 1491340 931248 SP_1586 Streptococcus pneumoniae TIGR4 ATP-dependent RNA helicase NP_346032.1 1489766 R 170187 CDS NP_346033.1 15901429 931247 complement(1491539..1492765) 1 NC_003028.3 oxalate:formate antiporter 1492765 931247 SP_1587 Streptococcus pneumoniae TIGR4 oxalate:formate antiporter NP_346033.1 1491539 R 170187 CDS NP_346034.1 15901430 931244 1492958..1494274 1 NC_003028.3 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 1494274 931244 SP_1588 Streptococcus pneumoniae TIGR4 pyridine nucleotide-disulfide oxidoreductase NP_346034.1 1492958 D 170187 CDS NP_346035.1 15901431 931245 1494373..1495716 1 NC_003028.3 hypothetical protein 1495716 931245 SP_1589 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346035.1 1494373 D 170187 CDS NP_346036.1 15901432 931263 1495716..1496498 1 NC_003028.3 hypothetical protein 1496498 931263 SP_1590 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346036.1 1495716 D 170187 CDS NP_346037.1 15901433 931254 1496624..1497706 1 NC_003028.3 identified by match to PFAM protein family HMM PF00557; proline dipeptidase 1497706 931254 SP_1591 Streptococcus pneumoniae TIGR4 proline dipeptidase NP_346037.1 1496624 D 170187 CDS NP_346038.1 15901434 931268 1497699..1497902 1 NC_003028.3 similar to PID:1196899; identified by sequence similarity; hypothetical protein 1497902 931268 SP_1592 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346038.1 1497699 D 170187 CDS NP_346039.1 15901435 931242 1499265..1500611 1 NC_003028.3 similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 1500611 931242 SP_1595 Streptococcus pneumoniae TIGR4 IS1380-Spn1 transposase NP_346039.1 1499265 D 170187 CDS NP_346040.1 15901436 931243 complement(1500752..1501006) 1 NC_003028.3 hypothetical protein 1501006 931243 SP_1596 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346040.1 1500752 R 170187 CDS NP_346041.1 15901437 931237 complement(1501234..1501695) 1 NC_003028.3 hypothetical protein 1501695 931237 SP_1597 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346041.1 1501234 R 170187 CDS NP_346042.1 15901438 931240 complement(1501673..1502446) 1 NC_003028.3 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 1502446 931240 SP_1598 Streptococcus pneumoniae TIGR4 phosphomethylpyrimidine kinase NP_346042.1 1501673 R 170187 CDS NP_346043.1 15901439 931236 complement(1502436..1503185) 1 NC_003028.3 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1503185 truA 931236 truA Streptococcus pneumoniae TIGR4 tRNA pseudouridine synthase A NP_346043.1 1502436 R 170187 CDS NP_346044.1 15901440 931226 complement(1503503..1504654) 1 NC_003028.3 hypothetical protein 1504654 931226 SP_1600 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346044.1 1503503 R 170187 CDS NP_346045.1 15901441 931228 complement(1504894..1505523) 1 NC_003028.3 hypothetical protein 1505523 931228 SP_1601 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346045.1 1504894 R 170187 CDS NP_346046.1 15901442 931234 complement(1505526..1505864) 1 NC_003028.3 phnA protein 1505864 931234 SP_1602 Streptococcus pneumoniae TIGR4 phnA protein NP_346046.1 1505526 R 170187 CDS NP_346047.1 15901443 931235 complement(1505995..1506666) 1 NC_003028.3 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1506666 cmk 931235 cmk Streptococcus pneumoniae TIGR4 cytidylate kinase NP_346047.1 1505995 R 170187 CDS NP_346048.1 15901444 931233 complement(1506675..1507151) 1 NC_003028.3 hypothetical protein 1507151 931233 SP_1604 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346048.1 1506675 R 170187 CDS NP_346049.1 15901445 931232 1507203..1507409 1 NC_003028.3 ferredoxin 1507409 931232 SP_1605 Streptococcus pneumoniae TIGR4 ferredoxin NP_346049.1 1507203 D 170187 CDS NP_346050.1 15901446 931483 complement(1507460..1508422) 1 NC_003028.3 glycosyl transferase family protein 1508422 931483 SP_1606 Streptococcus pneumoniae TIGR4 glycosyl transferase family protein NP_346050.1 1507460 R 170187 CDS NP_346051.1 15901447 931229 complement(1508427..1509446) 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR01179; UDP-glucose 4-epimerase 1509446 931229 SP_1607 Streptococcus pneumoniae TIGR4 UDP-glucose 4-epimerase NP_346051.1 1508427 R 170187 CDS NP_346052.1 15901448 931227 complement(1509747..1510850) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01266; oxidoreductase, DadA family protein 1510850 931227 SP_1608 Streptococcus pneumoniae TIGR4 oxidoreductase, DadA family protein NP_346052.1 1509747 R 170187 CDS NP_346053.1 15901449 931218 complement(1510867..1511664) 1 NC_003028.3 hypothetical protein 1511664 931218 SP_1609 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346053.1 1510867 R 170187 CDS NP_346054.1 15901450 931215 complement(1511651..1512328) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00452; hypothetical protein 1512328 931215 SP_1610 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346054.1 1511651 R 170187 CDS NP_346055.1 15901451 931211 1512686..1512790 1 NC_003028.3 hypothetical protein 1512790 931211 SP_1611 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346055.1 1512686 D 170187 CDS NP_346056.1 15901452 931225 1512877..1513869 1 NC_003028.3 similar to GP:3582249; identified by sequence similarity; hypothetical protein 1513869 931225 SP_1612 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346056.1 1512877 D 170187 CDS YP_873932.1 118090030 4484196 complement(1515589..1517556) 1 NC_003028.3 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1517556 recP-1 4484196 recP-1 Streptococcus pneumoniae TIGR4 transketolase YP_873932.1 1515589 R 170187 CDS NP_346057.1 15901453 931221 complement(1517593..1518288) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00834; allulose-6-phosphate 3-epimerase 1518288 931221 SP_1616 Streptococcus pneumoniae TIGR4 allulose-6-phosphate 3-epimerase NP_346057.1 1517593 R 170187 CDS NP_346058.1 15901454 931224 complement(1518299..1519384) 1 NC_003028.3 PTS system transporter subunit IIC 1519384 931224 SP_1617 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIC NP_346058.1 1518299 R 170187 CDS NP_346059.1 15901455 931223 complement(1519410..1519736) 1 NC_003028.3 PTS system transporter subunit IIB 1519736 931223 SP_1618 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIB NP_346059.1 1519410 R 170187 CDS NP_346060.1 15901456 931222 complement(1519749..1520198) 1 NC_003028.3 PTS system transporter subunit IIA 1520198 931222 SP_1619 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIA NP_346060.1 1519749 R 170187 CDS NP_346061.1 15901457 931220 complement(1520176..1520604) 1 NC_003028.3 PTS system nitrogen regulatory IIA 1520604 931220 SP_1620 Streptococcus pneumoniae TIGR4 PTS system nitrogen regulatory IIA NP_346061.1 1520176 R 170187 CDS YP_873933.1 118090041 931217 complement(1520597..1522060) 1 NC_003028.3 transcription antiterminator BglG family protein 1522060 931217 SP_1621 Streptococcus pneumoniae TIGR4 transcription antiterminator BglG family protein YP_873933.1 1520597 R 170187 CDS NP_346062.1 15901458 931216 1522724..1523197 1 NC_003028.3 IS200 family transposase 1523197 931216 SP_1622 Streptococcus pneumoniae TIGR4 IS200 family transposase NP_346062.1 1522724 D 170187 CDS NP_346063.1 15901459 931480 complement(1523328..1525664) 1 NC_003028.3 cation transporter E1-E2 family ATPase 1525664 931480 SP_1623 Streptococcus pneumoniae TIGR4 cation transporter E1-E2 family ATPase NP_346063.1 1523328 R 170187 CDS NP_346064.1 15901460 931482 1525797..1526546 1 NC_003028.3 identified by match to PFAM protein family HMM PF01553; acyltransferase 1526546 931482 SP_1624 Streptococcus pneumoniae TIGR4 acyltransferase NP_346064.1 1525797 D 170187 CDS NP_346065.1 15901461 931479 complement(1526838..1527452) 1 NC_003028.3 cadmium resistance transporter 1527452 931479 SP_1625 Streptococcus pneumoniae TIGR4 cadmium resistance transporter NP_346065.1 1526838 R 170187 CDS NP_346066.1 15901462 931214 complement(1528268..1528537) 1 NC_003028.3 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1528537 rpsO 931214 rpsO Streptococcus pneumoniae TIGR4 30S ribosomal protein S15 NP_346066.1 1528268 R 170187 CDS NP_346067.1 15901463 931213 complement(1528678..1529307) 1 NC_003028.3 hypothetical protein 1529307 931213 SP_1627 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346067.1 1528678 R 170187 CDS NP_346068.1 15901464 931212 1529535..1529744 1 NC_003028.3 hypothetical protein 1529744 931212 SP_1628 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346068.1 1529535 D 170187 CDS NP_346069.1 15901465 931209 1529814..1529918 1 NC_003028.3 hypothetical protein 1529918 931209 SP_1629 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346069.1 1529814 D 170187 CDS NP_346070.1 15901466 931199 1530109..1530498 1 NC_003028.3 hypothetical protein 1530498 931199 SP_1630 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346070.1 1530109 D 170187 CDS NP_346071.1 15901467 931203 1530556..1532499 1 NC_003028.3 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1532499 thrS 931203 thrS Streptococcus pneumoniae TIGR4 threonyl-tRNA synthetase NP_346071.1 1530556 D 170187 CDS NP_346072.1 15901468 931201 complement(1532548..1533522) 1 NC_003028.3 sensor histidine kinase 1533522 931201 SP_1632 Streptococcus pneumoniae TIGR4 sensor histidine kinase NP_346072.1 1532548 R 170187 CDS NP_346073.1 15901469 931206 complement(1533515..1534192) 1 NC_003028.3 DNA-binding response regulator 1534192 931206 SP_1633 Streptococcus pneumoniae TIGR4 DNA-binding response regulator NP_346073.1 1533515 R 170187 CDS NP_346074.1 15901470 931208 1534348..1535421 1 NC_003028.3 hypothetical protein 1535421 931208 SP_1634 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346074.1 1534348 D 170187 CDS NP_346075.1 15901471 931207 complement(1535512..1535814) 1 NC_003028.3 hypothetical protein 1535814 931207 SP_1635 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346075.1 1535512 R 170187 CDS NP_346076.1 15901472 931205 complement(1535882..1536319) 1 NC_003028.3 Rrf2 family protein 1536319 931205 SP_1636 Streptococcus pneumoniae TIGR4 Rrf2 family protein NP_346076.1 1535882 R 170187 CDS NP_346077.1 15901473 931202 complement(1536395..1537243) 1 NC_003028.3 hypothetical protein 1537243 931202 SP_1637 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346077.1 1536395 R 170187 CDS NP_346078.1 15901474 931200 1537349..1537999 1 NC_003028.3 identified by match to PFAM protein family HMM PF01325; iron-dependent transcriptional regulator 1537999 931200 SP_1638 Streptococcus pneumoniae TIGR4 iron-dependent transcriptional regulator NP_346078.1 1537349 D 170187 CDS NP_346079.1 15901475 931198 complement(1538071..1539345) 1 NC_003028.3 IS1167, transposase 1539345 931198 SP_1639 Streptococcus pneumoniae TIGR4 IS1167, transposase NP_346079.1 1538071 R 170187 CDS NP_346080.1 15901476 931197 1539742..1540263 1 NC_003028.3 hypothetical protein 1540263 931197 SP_1640 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346080.1 1539742 D 170187 CDS NP_346081.1 15901477 931196 1540394..1540807 1 NC_003028.3 similar to GB:AL009126; identified by sequence similarity; hypothetical protein 1540807 931196 SP_1641 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346081.1 1540394 D 170187 CDS NP_346082.1 15901478 931195 1540826..1541011 1 NC_003028.3 hypothetical protein 1541011 931195 SP_1642 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346082.1 1540826 D 170187 CDS NP_346083.1 15901479 931194 1541078..1541239 1 NC_003028.3 hypothetical protein 1541239 931194 SP_1643 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346083.1 1541078 D 170187 CDS NP_346084.1 15901480 931193 complement(1541278..1541721) 1 NC_003028.3 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 1541721 931193 SP_1644 Streptococcus pneumoniae TIGR4 D-tyrosyl-tRNA(Tyr) deacylase NP_346084.1 1541278 R 170187 CDS NP_346085.1 15901481 931192 complement(1541751..1543973) 1 NC_003028.3 GTP pyrophosphokinase 1543973 931192 SP_1645 Streptococcus pneumoniae TIGR4 GTP pyrophosphokinase NP_346085.1 1541751 R 170187 CDS NP_346086.1 15901482 931191 1544932..1545561 1 NC_003028.3 metallo-beta-lactamase superfamily protein 1545561 931191 SP_1646 Streptococcus pneumoniae TIGR4 metallo-beta-lactamase superfamily protein NP_346086.1 1544932 D 170187 CDS NP_346087.1 15901483 931189 complement(1545684..1547576) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01431; endopeptidase O 1547576 931189 SP_1647 Streptococcus pneumoniae TIGR4 endopeptidase O NP_346087.1 1545684 R 170187 CDS NP_346088.1 15901484 931188 1547867..1548589 1 NC_003028.3 manganese ABC transporter ATP-binding protein 1548589 931188 SP_1648 Streptococcus pneumoniae TIGR4 manganese ABC transporter ATP-binding protein NP_346088.1 1547867 D 170187 CDS YP_873934.1 118090037 931187 1548586..1549434 1 NC_003028.3 manganese ABC transporter permease 1549434 931187 SP_1649 Streptococcus pneumoniae TIGR4 manganese ABC transporter permease YP_873934.1 1548586 D 170187 CDS NP_346089.1 15901485 931186 1549466..1550395 1 NC_003028.3 identified by match to PFAM protein family HMM PF01297; manganese ABC transporter manganese-binding adhesion liprotein 1550395 931186 SP_1650 Streptococcus pneumoniae TIGR4 manganese ABC transporter manganese-binding adhesion liprotein NP_346089.1 1549466 D 170187 CDS NP_346090.3 255964977 931172 1550491..1551009 1 NC_003028.3 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1551009 tpx 931172 tpx Streptococcus pneumoniae TIGR4 thiol peroxidase NP_346090.3 1550491 D 170187 CDS NP_346091.1 15901487 931175 complement(1551105..1553879) 1 NC_003028.3 hypothetical protein 1553879 931175 SP_1652 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346091.1 1551105 R 170187 CDS NP_346092.1 15901488 931184 complement(1553815..1554516) 1 NC_003028.3 ABC transporter ATP-binding protein 1554516 931184 SP_1653 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_346092.1 1553815 R 170187 CDS NP_346093.1 15901489 931185 complement(1554766..1557177) 1 NC_003028.3 hypothetical protein 1557177 931185 SP_1654 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346093.1 1554766 R 170187 CDS NP_346094.1 15901490 931183 complement(1557230..1557922) 1 NC_003028.3 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 1557922 gpmA 931183 gpmA Streptococcus pneumoniae TIGR4 phosphoglyceromutase NP_346094.1 1557230 R 170187 CDS NP_346095.1 15901491 931182 complement(1557973..1558161) 1 NC_003028.3 hypothetical protein 1558161 931182 SP_1656 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346095.1 1557973 R 170187 CDS NP_346096.1 15901492 931181 1558244..1558468 1 NC_003028.3 hypothetical protein 1558468 931181 SP_1657 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346096.1 1558244 D 170187 CDS NP_346097.1 15901493 931180 complement(1558537..1558797) 1 NC_003028.3 hypothetical protein 1558797 931180 SP_1658 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346097.1 1558537 R 170187 CDS NP_346098.1 15901494 931179 complement(1559245..1562037) 1 NC_003028.3 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1562037 ileS 931179 ileS Streptococcus pneumoniae TIGR4 isoleucyl-tRNA synthetase NP_346098.1 1559245 R 170187 CDS NP_346099.1 15901495 931176 complement(1562181..1562342) 1 NC_003028.3 hypothetical protein 1562342 931176 SP_1660 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346099.1 1562181 R 170187 CDS NP_346100.1 15901496 931174 complement(1562385..1563173) 1 NC_003028.3 similar to GP:4009475; identified by sequence similarity; cell division protein DivIVA 1563173 931174 SP_1661 Streptococcus pneumoniae TIGR4 cell division protein DivIVA NP_346100.1 1562385 R 170187 CDS NP_346101.1 15901497 931171 complement(1563182..1563967) 1 NC_003028.3 hypothetical protein 1563967 931171 SP_1662 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346101.1 1563182 R 170187 CDS NP_346102.1 15901498 931170 complement(1563964..1564227) 1 NC_003028.3 similar to GP:4009473; identified by sequence similarity; hypothetical protein 1564227 931170 SP_1663 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346102.1 1563964 R 170187 CDS NP_346103.1 15901499 931177 complement(1564227..1564766) 1 NC_003028.3 similar to GP:4009472; identified by sequence similarity; hypothetical protein 1564766 931177 SP_1664 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346103.1 1564227 R 170187 CDS NP_346104.1 15901500 931157 complement(1564776..1565447) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01168; hypothetical protein 1565447 931157 SP_1665 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346104.1 1564776 R 170187 CDS NP_346105.1 15901501 931159 complement(1565452..1566711) 1 NC_003028.3 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1566711 931159 SP_1666 Streptococcus pneumoniae TIGR4 cell division protein FtsZ NP_346105.1 1565452 R 170187 CDS NP_346106.1 15901502 931204 complement(1566728..1568101) 1 NC_003028.3 identified by match to PFAM protein family HMM PF02491; cell division protein FtsA 1568101 931204 SP_1667 Streptococcus pneumoniae TIGR4 cell division protein FtsA NP_346106.1 1566728 R 170187 CDS NP_346107.1 15901503 931169 complement(1568320..1569024) 1 NC_003028.3 hypothetical protein 1569024 931169 SP_1668 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346107.1 1568320 R 170187 CDS NP_346108.1 15901504 931168 complement(1569115..1569726) 1 NC_003028.3 MutT/nudix family protein 1569726 931168 SP_1669 Streptococcus pneumoniae TIGR4 MutT/nudix family protein NP_346108.1 1569115 R 170187 CDS NP_346109.1 15901505 931167 complement(1569713..1571086) 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR01143; UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase 1571086 931167 SP_1670 Streptococcus pneumoniae TIGR4 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase NP_346109.1 1569713 R 170187 CDS NP_346110.1 15901506 931166 complement(1571170..1572213) 1 NC_003028.3 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 1572213 ddl 931166 ddl Streptococcus pneumoniae TIGR4 D-alanyl-alanine synthetase A NP_346110.1 1571170 R 170187 CDS NP_346111.1 15901507 931165 complement(1572389..1572985) 1 NC_003028.3 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1572985 recR 931165 recR Streptococcus pneumoniae TIGR4 recombination protein RecR NP_346111.1 1572389 R 170187 CDS NP_346112.1 15901508 931164 complement(1572996..1575038) 1 NC_003028.3 penicillin-binding protein 2B 1575038 931164 SP_1673 Streptococcus pneumoniae TIGR4 penicillin-binding protein 2B NP_346112.1 1572996 R 170187 CDS NP_346113.1 15901509 931163 1575253..1576104 1 NC_003028.3 phosphosugar-binding transcriptional regulator 1576104 931163 SP_1674 Streptococcus pneumoniae TIGR4 phosphosugar-binding transcriptional regulator NP_346113.1 1575253 D 170187 CDS NP_346114.1 15901510 931162 complement(1576120..1577004) 1 NC_003028.3 ROK family protein 1577004 931162 SP_1675 Streptococcus pneumoniae TIGR4 ROK family protein NP_346114.1 1576120 R 170187 CDS NP_346115.1 15901511 931161 complement(1577022..1577939) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00701; N-acetylneuraminate lyase 1577939 931161 SP_1676 Streptococcus pneumoniae TIGR4 N-acetylneuraminate lyase NP_346115.1 1577022 R 170187 CDS NP_346116.1 15901512 931160 complement(1578108..1578752) 1 NC_003028.3 hypothetical protein 1578752 931160 SP_1677 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346116.1 1578108 R 170187 CDS NP_346117.1 15901513 931156 complement(1578734..1578832) 1 NC_003028.3 hypothetical protein 1578832 931156 SP_1678 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346117.1 1578734 R 170187 CDS NP_346118.1 15901514 931148 complement(1579029..1579373) 1 NC_003028.3 hypothetical protein 1579373 931148 SP_1679 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346118.1 1579029 R 170187 CDS NP_346119.1 15901515 931152 complement(1579470..1579922) 1 NC_003028.3 hypothetical protein 1579922 931152 SP_1680 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346119.1 1579470 R 170187 CDS NP_346120.1 15901516 931154 complement(1580194..1581033) 1 NC_003028.3 sugar ABC transporter permease 1581033 931154 SP_1681 Streptococcus pneumoniae TIGR4 sugar ABC transporter permease NP_346120.1 1580194 R 170187 CDS NP_346121.1 15901517 931155 complement(1581049..1581945) 1 NC_003028.3 sugar ABC transporter permease 1581945 931155 SP_1682 Streptococcus pneumoniae TIGR4 sugar ABC transporter permease NP_346121.1 1581049 R 170187 CDS NP_346122.1 15901518 931153 complement(1582167..1583495) 1 NC_003028.3 sugar ABC transporter substrate-binding protein 1583495 931153 SP_1683 Streptococcus pneumoniae TIGR4 sugar ABC transporter substrate-binding protein NP_346122.1 1582167 R 170187 CDS NP_346123.1 15901519 931151 complement(1583620..1585137) 1 NC_003028.3 PTS system transporter subunit IIBC 1585137 931151 SP_1684 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIBC NP_346123.1 1583620 R 170187 CDS NP_346124.1 15901520 931150 complement(1585156..1585854) 1 NC_003028.3 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 1585854 931150 SP_1685 Streptococcus pneumoniae TIGR4 N-acetylmannosamine-6-phosphate 2-epimerase NP_346124.1 1585156 R 170187 CDS NP_346125.1 15901521 931149 complement(1586028..1587131) 1 NC_003028.3 Gfo/Idh/MocA family oxidoreductase 1587131 931149 SP_1686 Streptococcus pneumoniae TIGR4 Gfo/Idh/MocA family oxidoreductase NP_346125.1 1586028 R 170187 CDS NP_346126.1 15901522 931147 complement(1587143..1589236) 1 NC_003028.3 neuraminidase B 1589236 931147 SP_1687 Streptococcus pneumoniae TIGR4 neuraminidase B NP_346126.1 1587143 R 170187 CDS NP_346127.1 15901523 931134 complement(1589254..1590087) 1 NC_003028.3 ABC transporter permease 1590087 931134 SP_1688 Streptococcus pneumoniae TIGR4 ABC transporter permease NP_346127.1 1589254 R 170187 CDS NP_346128.1 15901524 931140 complement(1590087..1590971) 1 NC_003028.3 ABC transporter permease 1590971 931140 SP_1689 Streptococcus pneumoniae TIGR4 ABC transporter permease NP_346128.1 1590087 R 170187 CDS NP_346129.1 15901525 931141 complement(1591050..1592387) 1 NC_003028.3 ABC transporter substrate-binding protein 1592387 931141 SP_1690 Streptococcus pneumoniae TIGR4 ABC transporter substrate-binding protein NP_346129.1 1591050 R 170187 CDS NP_346130.1 15901526 931143 complement(1592406..1592858) 1 NC_003028.3 hypothetical protein 1592858 931143 SP_1691 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346130.1 1592406 R 170187 CDS NP_346131.1 15901527 931146 1593972..1595228 1 NC_003028.3 IS1167, transposase 1595228 931146 SP_1692 Streptococcus pneumoniae TIGR4 IS1167, transposase NP_346131.1 1593972 D 170187 CDS NP_346132.1 15901528 931144 complement(1598470..1598697) 1 NC_003028.3 hypothetical protein 1598697 931144 SP_1694 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346132.1 1598470 R 170187 CDS NP_346133.1 15901529 931142 complement(1599458..1600438) 1 NC_003028.3 similar to GP:7160626; identified by sequence similarity; acetyl xylan esterase 1600438 931142 SP_1695 Streptococcus pneumoniae TIGR4 acetyl xylan esterase NP_346133.1 1599458 R 170187 CDS NP_346134.1 15901530 931139 complement(1600611..1600718) 1 NC_003028.3 hypothetical protein 1600718 931139 SP_1696 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346134.1 1600611 R 170187 CDS NP_346135.1 15901531 931138 complement(1600953..1602968) 1 NC_003028.3 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 1602968 931138 SP_1697 Streptococcus pneumoniae TIGR4 ATP-dependent DNA helicase RecG NP_346135.1 1600953 R 170187 CDS NP_346136.1 15901532 931137 complement(1602987..1604090) 1 NC_003028.3 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 1604090 alr 931137 alr Streptococcus pneumoniae TIGR4 alanine racemase NP_346136.1 1602987 R 170187 CDS NP_346137.1 15901533 931136 complement(1604080..1604442) 1 NC_003028.3 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1604442 acpS 931136 acpS Streptococcus pneumoniae TIGR4 4'-phosphopantetheinyl transferase NP_346137.1 1604080 R 170187 CDS NP_346138.1 15901534 931135 complement(1604487..1605518) 1 NC_003028.3 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1605518 931135 SP_1700 Streptococcus pneumoniae TIGR4 phospho-2-dehydro-3-deoxyheptonate aldolase NP_346138.1 1604487 R 170187 CDS NP_346139.1 15901535 931132 complement(1605520..1606551) 1 NC_003028.3 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1606551 931132 SP_1701 Streptococcus pneumoniae TIGR4 phospho-2-dehydro-3-deoxyheptonate aldolase NP_346139.1 1605520 R 170187 CDS NP_346140.1 15901536 931130 complement(1606632..1609145) 1 NC_003028.3 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1609145 secA 931130 secA Streptococcus pneumoniae TIGR4 preprotein translocase subunit SecA NP_346140.1 1606632 R 170187 CDS NP_346141.1 15901537 931129 complement(1609291..1609578) 1 NC_003028.3 similar to SP:Q09208 PID:643105; identified by sequence similarity; hypothetical protein 1609578 931129 SP_1703 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346141.1 1609291 R 170187 CDS NP_346142.1 15901538 931128 complement(1609606..1610238) 1 NC_003028.3 ABC transporter ATP-binding protein 1610238 931128 SP_1704 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_346142.1 1609606 R 170187 CDS NP_346143.1 15901539 931127 complement(1610242..1610883) 1 NC_003028.3 hypothetical protein 1610883 931127 SP_1705 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346143.1 1610242 R 170187 CDS NP_346144.1 15901540 931126 complement(1610876..1611667) 1 NC_003028.3 hypothetical protein 1611667 931126 SP_1706 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346144.1 1610876 R 170187 CDS NP_346145.1 15901541 931125 complement(1611852..1612190) 1 NC_003028.3 hypothetical protein 1612190 931125 SP_1707 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346145.1 1611852 R 170187 CDS NP_346146.1 15901542 931124 complement(1612327..1612671) 1 NC_003028.3 hypothetical protein 1612671 931124 SP_1708 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346146.1 1612327 R 170187 CDS NP_346147.1 15901543 931123 complement(1612751..1614061) 1 NC_003028.3 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1614061 engA 931123 engA Streptococcus pneumoniae TIGR4 GTP-binding protein EngA NP_346147.1 1612751 R 170187 CDS NP_346148.1 15901544 931122 complement(1614075..1614788) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00881; nitroreductase 1614788 931122 SP_1710 Streptococcus pneumoniae TIGR4 nitroreductase NP_346148.1 1614075 R 170187 CDS NP_346149.1 15901545 931121 complement(1614785..1615681) 1 NC_003028.3 Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI 1615681 931121 SP_1711 Streptococcus pneumoniae TIGR4 primosomal protein DnaI NP_346149.1 1614785 R 170187 CDS NP_346150.1 15901546 931120 complement(1615682..1616851) 1 NC_003028.3 hypothetical protein 1616851 931120 SP_1712 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346150.1 1615682 R 170187 CDS NP_346151.1 15901547 931119 complement(1616852..1617325) 1 NC_003028.3 transcriptional regulator NrdR 1617325 nrdR 931119 nrdR Streptococcus pneumoniae TIGR4 transcriptional regulator NrdR NP_346151.1 1616852 R 170187 CDS NP_346152.1 15901548 931118 1617465..1617830 1 NC_003028.3 GntR family transcriptional regulator 1617830 931118 SP_1714 Streptococcus pneumoniae TIGR4 GntR family transcriptional regulator NP_346152.1 1617465 D 170187 CDS NP_346153.1 15901549 931117 1617835..1619313 1 NC_003028.3 hypothetical protein 1619313 931117 SP_1715 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346153.1 1617835 D 170187 CDS NP_346154.1 15901550 931116 complement(1619725..1620924) 1 NC_003028.3 hypothetical protein 1620924 931116 SP_1716 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346154.1 1619725 R 170187 CDS NP_346155.1 15901551 931115 complement(1620921..1621814) 1 NC_003028.3 ABC transporter ATP-binding protein 1621814 931115 SP_1717 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_346155.1 1620921 R 170187 CDS NP_346156.1 15901552 931114 complement(1622205..1622306) 1 NC_003028.3 hypothetical protein 1622306 931114 SP_1718 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346156.1 1622205 R 170187 CDS NP_346157.1 15901553 931112 1623130..1623747 1 NC_003028.3 hypothetical protein 1623747 931112 SP_1720 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346157.1 1623130 D 170187 CDS NP_346158.1 15901554 931111 complement(1624067..1624954) 1 NC_003028.3 fructokinase 1624954 931111 SP_1721 Streptococcus pneumoniae TIGR4 fructokinase NP_346158.1 1624067 R 170187 CDS NP_346159.1 15901555 931110 complement(1625103..1626986) 1 NC_003028.3 identified by match to PFAM protein family HMM PF02378; PTS system IIABC components 1626986 931110 SP_1722 Streptococcus pneumoniae TIGR4 PTS system IIABC components NP_346159.1 1625103 R 170187 CDS NP_346160.1 15901556 931109 complement(1627112..1627309) 1 NC_003028.3 hypothetical protein 1627309 931109 SP_1723 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346160.1 1627112 R 170187 CDS NP_346161.1 15901557 931108 1627362..1628816 1 NC_003028.3 sucrose-6-phosphate hydrolase 1628816 931108 SP_1724 Streptococcus pneumoniae TIGR4 sucrose-6-phosphate hydrolase NP_346161.1 1627362 D 170187 CDS NP_346162.1 15901558 931107 1628797..1629762 1 NC_003028.3 sucrose operon repressor 1629762 931107 SP_1725 Streptococcus pneumoniae TIGR4 sucrose operon repressor NP_346162.1 1628797 D 170187 CDS NP_346163.1 15901559 931106 complement(1629797..1631071) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00368; 3-hydroxy-3-methylglutaryl-CoA reductase 1631071 931106 SP_1726 Streptococcus pneumoniae TIGR4 3-hydroxy-3-methylglutaryl-CoA reductase NP_346163.1 1629797 R 170187 CDS NP_346164.1 15901560 931105 complement(1631071..1632267) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01154; hydroxymethylglutaryl-CoA synthase 1632267 931105 SP_1727 Streptococcus pneumoniae TIGR4 hydroxymethylglutaryl-CoA synthase NP_346164.1 1631071 R 170187 CDS NP_346165.1 15901561 931103 complement(1632374..1632661) 1 NC_003028.3 hypothetical protein 1632661 931103 SP_1728 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346165.1 1632374 R 170187 CDS YP_873935.1 118090042 931104 complement(1632690..1633310) 1 NC_003028.3 OrfA/OrfB; truncated IS1381 transposase 1633310 931104 SP_1729 Streptococcus pneumoniae TIGR4 truncated IS1381 transposase YP_873935.1 1632690 R 170187 CDS NP_346166.1 15901562 931102 complement(1633375..1633824) 1 NC_003028.3 hypothetical protein 1633824 931102 SP_1730 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346166.1 1633375 R 170187 CDS NP_346167.1 15901563 931100 complement(1633826..1634584) 1 NC_003028.3 hypothetical protein 1634584 931100 SP_1731 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346167.1 1633826 R 170187 CDS NP_346168.1 15901564 931099 complement(1634699..1636678) 1 NC_003028.3 serine/threonine protein kinase 1636678 931099 SP_1732 Streptococcus pneumoniae TIGR4 serine/threonine protein kinase NP_346168.1 1634699 R 170187 CDS NP_346169.1 15901565 931178 complement(1636675..1637415) 1 NC_003028.3 phosphatase 1637415 931178 SP_1733 Streptococcus pneumoniae TIGR4 phosphatase NP_346169.1 1636675 R 170187 CDS NP_346170.1 15901566 930635 complement(1637430..1638743) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01029; rRNA methyltransferase RsmB 1638743 930635 SP_1734 Streptococcus pneumoniae TIGR4 rRNA methyltransferase RsmB NP_346170.1 1637430 R 170187 CDS NP_346171.1 15901567 931089 complement(1638736..1639671) 1 NC_003028.3 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1639671 fmt 931089 fmt Streptococcus pneumoniae TIGR4 methionyl-tRNA formyltransferase NP_346171.1 1638736 R 170187 CDS NP_346172.1 15901568 931098 complement(1639684..1642080) 1 NC_003028.3 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1642080 931098 SP_1736 Streptococcus pneumoniae TIGR4 primosome assembly protein PriA NP_346172.1 1639684 R 170187 CDS NP_346173.1 15901569 931097 complement(1642146..1642457) 1 NC_003028.3 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1642457 931097 SP_1737 Streptococcus pneumoniae TIGR4 DNA-directed RNA polymerase subunit omega NP_346173.1 1642146 R 170187 CDS NP_346174.1 15901570 931096 complement(1642485..1643111) 1 NC_003028.3 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1643111 gmk 931096 gmk Streptococcus pneumoniae TIGR4 guanylate kinase NP_346174.1 1642485 R 170187 CDS NP_346175.1 15901571 931095 complement(1643241..1644845) 1 NC_003028.3 hypothetical protein 1644845 931095 SP_1739 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346175.1 1643241 R 170187 CDS NP_346176.1 15901572 931094 complement(1645045..1645299) 1 NC_003028.3 hypothetical protein 1645299 931094 SP_1740 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346176.1 1645045 R 170187 CDS NP_346177.1 15901573 931093 complement(1645303..1645557) 1 NC_003028.3 hypothetical protein 1645557 931093 SP_1741 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346177.1 1645303 R 170187 CDS NP_346178.1 15901574 931092 complement(1645795..1646892) 1 NC_003028.3 hypothetical protein 1646892 931092 SP_1742 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346178.1 1645795 R 170187 CDS NP_346179.1 15901575 931091 complement(1646902..1647648) 1 NC_003028.3 hypothetical protein 1647648 931091 SP_1743 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346179.1 1646902 R 170187 CDS NP_346180.1 15901576 931090 complement(1647751..1648104) 1 NC_003028.3 iojap-like protein 1648104 931090 SP_1744 Streptococcus pneumoniae TIGR4 iojap-like protein NP_346180.1 1647751 R 170187 CDS NP_346181.1 15901577 931088 complement(1648117..1648617) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00857; isochorismatase 1648617 931088 SP_1745 Streptococcus pneumoniae TIGR4 isochorismatase NP_346181.1 1648117 R 170187 CDS NP_346182.1 15901578 931087 complement(1648618..1649211) 1 NC_003028.3 hypothetical protein 1649211 931087 SP_1746 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346182.1 1648618 R 170187 CDS NP_346183.1 15901579 931086 complement(1649211..1649840) 1 NC_003028.3 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 1649840 nadD 931086 nadD Streptococcus pneumoniae TIGR4 nicotinic acid mononucleotide adenylyltransferase NP_346183.1 1649211 R 170187 CDS NP_346184.1 15901580 931085 complement(1649892..1650203) 1 NC_003028.3 hypothetical protein 1650203 931085 SP_1748 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346184.1 1649892 R 170187 CDS NP_346185.1 15901581 931084 complement(1650417..1651523) 1 NC_003028.3 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH 1651523 931084 SP_1749 Streptococcus pneumoniae TIGR4 GTP-binding protein YqeH NP_346185.1 1650417 R 170187 CDS NP_346186.1 15901582 931083 complement(1651526..1652053) 1 NC_003028.3 hypothetical protein 1652053 931083 SP_1750 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346186.1 1651526 R 170187 CDS NP_346187.1 15901583 931082 complement(1652068..1652976) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01544; magnesium/cobalt transporter CorA 1652976 931082 SP_1751 Streptococcus pneumoniae TIGR4 magnesium/cobalt transporter CorA NP_346187.1 1652068 R 170187 CDS NP_346188.1 15901584 931081 complement(1653033..1653638) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00924; mechanosensitive ion channel MscS 1653638 931081 SP_1752 Streptococcus pneumoniae TIGR4 mechanosensitive ion channel MscS NP_346188.1 1653033 R 170187 CDS NP_346189.1 15901585 931078 1655009..1655962 1 NC_003028.3 hypothetical protein 1655962 931078 SP_1754 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346189.1 1655009 D 170187 CDS NP_346190.1 15901586 931079 complement(1656378..1656602) 1 NC_003028.3 hypothetical protein 1656602 931079 SP_1755 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346190.1 1656378 R 170187 CDS NP_346191.1 15901587 931077 complement(1656607..1656786) 1 NC_003028.3 similar to GB:AE000657; identified by sequence similarity; hypothetical protein 1656786 931077 SP_1756 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346191.1 1656607 R 170187 CDS NP_346192.1 15901588 931076 complement(1656788..1658125) 1 NC_003028.3 hypothetical protein 1658125 931076 SP_1757 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346192.1 1656788 R 170187 CDS NP_346193.1 15901589 931075 complement(1658118..1659629) 1 NC_003028.3 group 1 glycosyl transferase 1659629 931075 SP_1758 Streptococcus pneumoniae TIGR4 group 1 glycosyl transferase NP_346193.1 1658118 R 170187 CDS NP_346194.1 15901590 931074 complement(1659641..1662013) 1 NC_003028.3 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins; preprotein translocase subunit SecA 1662013 931074 SP_1759 Streptococcus pneumoniae TIGR4 preprotein translocase subunit SecA NP_346194.1 1659641 R 170187 CDS NP_346195.1 15901591 931073 complement(1662006..1662446) 1 NC_003028.3 similar to SP:P39684 PID:836778; identified by sequence similarity; hypothetical protein 1662446 931073 SP_1760 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346195.1 1662006 R 170187 CDS NP_346196.1 15901592 931072 complement(1662443..1663978) 1 NC_003028.3 hypothetical protein 1663978 931072 SP_1761 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346196.1 1662443 R 170187 CDS NP_346197.1 15901593 931071 complement(1663962..1665542) 1 NC_003028.3 hypothetical protein 1665542 931071 SP_1762 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346197.1 1663962 R 170187 CDS NP_346198.1 15901594 931070 complement(1665552..1666769) 1 NC_003028.3 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 1666769 secY 931070 secY Streptococcus pneumoniae TIGR4 preprotein translocase subunit SecY NP_346198.1 1665552 R 170187 CDS NP_346199.1 15901595 931069 complement(1666826..1667731) 1 NC_003028.3 glycosyl transferase family protein 1667731 931069 SP_1764 Streptococcus pneumoniae TIGR4 glycosyl transferase family protein NP_346199.1 1666826 R 170187 CDS NP_346200.1 15901596 931068 complement(1667731..1668927) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01501; glycosyl transferase family protein 1668927 931068 SP_1765 Streptococcus pneumoniae TIGR4 glycosyl transferase family protein NP_346200.1 1667731 R 170187 CDS NP_346201.1 15901597 931067 complement(1668936..1670156) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01501; glycosyl transferase family protein 1670156 931067 SP_1766 Streptococcus pneumoniae TIGR4 glycosyl transferase family protein NP_346201.1 1668936 R 170187 CDS NP_346202.1 15901598 931066 complement(1670187..1672631) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01501; glycosyl transferase family protein 1672631 931066 SP_1767 Streptococcus pneumoniae TIGR4 glycosyl transferase family protein NP_346202.1 1670187 R 170187 CDS NP_346203.1 15901599 931065 complement(1672641..1673651) 1 NC_003028.3 hypothetical protein 1673651 931065 SP_1768 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346203.1 1672641 R 170187 CDS NP_346204.1 15901600 931052 complement(1674561..1675775) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01501; glycosyl transferase family protein 1675775 931052 SP_1770 Streptococcus pneumoniae TIGR4 glycosyl transferase family protein NP_346204.1 1674561 R 170187 CDS NP_346205.1 15901601 931055 complement(1676082..1678172) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01501; glycosyl transferase family protein 1678172 931055 SP_1771 Streptococcus pneumoniae TIGR4 glycosyl transferase family protein NP_346205.1 1676082 R 170187 CDS NP_346206.1 15901602 931060 complement(1678227..1692557) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00746; cell wall surface anchor family protein 1692557 931060 SP_1772 Streptococcus pneumoniae TIGR4 cell wall surface anchor family protein NP_346206.1 1678227 R 170187 CDS NP_346207.1 15901603 931062 1693715..1694176 1 NC_003028.3 transcriptional regulator 1694176 931062 SP_1774 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_346207.1 1693715 D 170187 CDS NP_346208.1 15901604 931061 1694194..1694496 1 NC_003028.3 similar to GP:3980554; identified by sequence similarity; hypothetical protein 1694496 931061 SP_1775 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346208.1 1694194 D 170187 CDS NP_346209.1 15901605 931059 1694513..1694827 1 NC_003028.3 thioredoxin 1694827 931059 SP_1776 Streptococcus pneumoniae TIGR4 thioredoxin NP_346209.1 1694513 D 170187 CDS NP_346210.1 15901606 931058 1695201..1695665 1 NC_003028.3 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 1695665 931058 SP_1777 Streptococcus pneumoniae TIGR4 7-cyano-7-deazaguanine reductase NP_346210.1 1695201 D 170187 CDS NP_346211.1 15901607 931056 complement(1696189..1696857) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00230; aquaporin 1696857 931056 SP_1778 Streptococcus pneumoniae TIGR4 aquaporin NP_346211.1 1696189 R 170187 CDS NP_346212.1 15901608 931057 complement(1696968..1697528) 1 NC_003028.3 hypothetical protein 1697528 931057 SP_1779 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346212.1 1696968 R 170187 CDS NP_346213.1 15901609 931054 complement(1697768..1699564) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01432; oligoendopeptidase F 1699564 931054 SP_1780 Streptococcus pneumoniae TIGR4 oligoendopeptidase F NP_346213.1 1697768 R 170187 CDS NP_346214.1 15901610 931053 complement(1699575..1700318) 1 NC_003028.3 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 1700318 931053 SP_1781 Streptococcus pneumoniae TIGR4 16S ribosomal RNA methyltransferase RsmE NP_346214.1 1699575 R 170187 CDS NP_346215.1 15901611 931051 complement(1700320..1701270) 1 NC_003028.3 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 1701270 prmA 931051 prmA Streptococcus pneumoniae TIGR4 50S ribosomal protein L11 methyltransferase NP_346215.1 1700320 R 170187 CDS NP_346216.1 15901612 931050 complement(1701406..1701834) 1 NC_003028.3 MutT/nudix family protein 1701834 931050 SP_1783 Streptococcus pneumoniae TIGR4 MutT/nudix family protein NP_346216.1 1701406 R 170187 CDS NP_346217.1 15901613 931049 complement(1701815..1702903) 1 NC_003028.3 hypothetical protein 1702903 931049 SP_1784 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346217.1 1701815 R 170187 CDS NP_346218.1 15901614 931048 complement(1702922..1703392) 1 NC_003028.3 hypothetical protein 1703392 931048 SP_1785 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346218.1 1702922 R 170187 CDS NP_346219.1 15901615 931047 complement(1703683..1704135) 1 NC_003028.3 hypothetical protein 1704135 931047 SP_1786 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346219.1 1703683 R 170187 CDS NP_346220.1 15901616 931046 complement(1704172..1704378) 1 NC_003028.3 hypothetical protein 1704378 931046 SP_1787 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346220.1 1704172 R 170187 CDS NP_346221.1 15901617 931045 complement(1704738..1704842) 1 NC_003028.3 hypothetical protein 1704842 931045 SP_1788 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346221.1 1704738 R 170187 CDS NP_346222.1 15901618 931042 complement(1704832..1705053) 1 NC_003028.3 hypothetical protein 1705053 931042 SP_1789 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346222.1 1704832 R 170187 CDS NP_346223.1 15901619 931043 1705345..1706616 1 NC_003028.3 recombination factor protein RarA 1706616 931043 SP_1790 Streptococcus pneumoniae TIGR4 recombination factor protein RarA NP_346223.1 1705345 D 170187 CDS NP_346224.1 15901620 931041 complement(1707036..1707152) 1 NC_003028.3 similar to GP:758229; identified by sequence similarity; integrase-like protein 1707152 931041 SP_1791 Streptococcus pneumoniae TIGR4 integrase-like protein NP_346224.1 1707036 R 170187 CDS NP_346225.1 15901621 931040 complement(1707173..1708429) 1 NC_003028.3 IS1167, transposase 1708429 931040 SP_1792 Streptococcus pneumoniae TIGR4 IS1167, transposase NP_346225.1 1707173 R 170187 CDS NP_346226.1 15901622 931039 complement(1708735..1709310) 1 NC_003028.3 hypothetical protein 1709310 931039 SP_1793 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346226.1 1708735 R 170187 CDS NP_346227.1 15901623 931038 complement(1709561..1709986) 1 NC_003028.3 hypothetical protein 1709986 931038 SP_1794 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346227.1 1709561 R 170187 CDS NP_346228.1 15901624 931037 complement(1710372..1711691) 1 NC_003028.3 sucrose-6-phosphate hydrolase 1711691 931037 SP_1795 Streptococcus pneumoniae TIGR4 sucrose-6-phosphate hydrolase NP_346228.1 1710372 R 170187 CDS NP_346229.1 15901625 931036 complement(1711701..1713317) 1 NC_003028.3 ABC transporter substrate-binding protein 1713317 931036 SP_1796 Streptococcus pneumoniae TIGR4 ABC transporter substrate-binding protein NP_346229.1 1711701 R 170187 CDS NP_346230.1 15901626 930997 complement(1713346..1714263) 1 NC_003028.3 ABC transporter permease 1714263 930997 SP_1797 Streptococcus pneumoniae TIGR4 ABC transporter permease NP_346230.1 1713346 R 170187 CDS NP_346231.1 15901627 931001 complement(1714247..1715164) 1 NC_003028.3 ABC transporter permease 1715164 931001 SP_1798 Streptococcus pneumoniae TIGR4 ABC transporter permease NP_346231.1 1714247 R 170187 CDS NP_346232.1 15901628 931002 complement(1715315..1716316) 1 NC_003028.3 LacI family transcriptional regulator 1716316 931002 SP_1799 Streptococcus pneumoniae TIGR4 LacI family transcriptional regulator NP_346232.1 1715315 R 170187 CDS NP_346233.1 15901629 931019 complement(1716678..1718159) 1 NC_003028.3 similar to GP:409925; identified by sequence similarity; transcriptional activator 1718159 931019 SP_1800 Streptococcus pneumoniae TIGR4 transcriptional activator NP_346233.1 1716678 R 170187 CDS NP_346234.1 15901630 931035 1718602..1718766 1 NC_003028.3 hypothetical protein 1718766 931035 SP_1801 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346234.1 1718602 D 170187 CDS NP_346235.1 15901631 931034 1718844..1719416 1 NC_003028.3 hypothetical protein 1719416 931034 SP_1802 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346235.1 1718844 D 170187 CDS NP_346236.1 15901632 931033 1719428..1719598 1 NC_003028.3 hypothetical protein 1719598 931033 SP_1803 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346236.1 1719428 D 170187 CDS NP_346237.1 15901633 931032 1719637..1720245 1 NC_003028.3 similar to PID:2274940; identified by sequence similarity; general stress protein 24 1720245 931032 SP_1804 Streptococcus pneumoniae TIGR4 general stress protein 24 NP_346237.1 1719637 D 170187 CDS NP_346238.1 15901634 931031 1720276..1720479 1 NC_003028.3 hypothetical protein 1720479 931031 SP_1805 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346238.1 1720276 D 170187 CDS NP_346239.1 15901635 931030 complement(1720589..1720828) 1 NC_003028.3 similar to GP:8918792; identified by sequence similarity; hypothetical protein 1720828 931030 SP_1806 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346239.1 1720589 R 170187 CDS NP_346240.1 15901636 931029 complement(1721006..1721452) 1 NC_003028.3 acetyltransferase 1721452 931029 SP_1807 Streptococcus pneumoniae TIGR4 acetyltransferase NP_346240.1 1721006 R 170187 CDS NP_346241.1 15901637 931028 1721522..1722181 1 NC_003028.3 identified by match to PFAM protein family HMM PF01478; type IV prepilin peptidase 1722181 931028 SP_1808 Streptococcus pneumoniae TIGR4 type IV prepilin peptidase NP_346241.1 1721522 D 170187 CDS NP_346242.1 15901638 931026 complement(1722233..1723384) 1 NC_003028.3 transcriptional regulator 1723384 931026 SP_1809 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_346242.1 1722233 R 170187 CDS NP_346243.1 15901639 931027 complement(1723399..1724130) 1 NC_003028.3 hypothetical protein 1724130 931027 SP_1810 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346243.1 1723399 R 170187 CDS NP_346244.1 15901640 931025 complement(1724432..1725208) 1 NC_003028.3 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1725208 trpA 931025 trpA Streptococcus pneumoniae TIGR4 tryptophan synthase subunit alpha NP_346244.1 1724432 R 170187 CDS NP_346245.1 15901641 931024 complement(1725201..1726424) 1 NC_003028.3 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1726424 931024 SP_1812 Streptococcus pneumoniae TIGR4 tryptophan synthase subunit beta NP_346245.1 1725201 R 170187 CDS NP_346246.1 15901642 931023 complement(1726402..1727001) 1 NC_003028.3 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase 1727001 931023 SP_1813 Streptococcus pneumoniae TIGR4 N-(5'-phosphoribosyl)anthranilate isomerase NP_346246.1 1726402 R 170187 CDS NP_346247.1 15901643 931022 complement(1726988..1727755) 1 NC_003028.3 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol phosphate synthase 1727755 trpC 931022 trpC Streptococcus pneumoniae TIGR4 indole-3-glycerol phosphate synthase NP_346247.1 1726988 R 170187 CDS NP_346248.1 15901644 931021 complement(1727752..1728756) 1 NC_003028.3 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1728756 trpD 931021 trpD Streptococcus pneumoniae TIGR4 anthranilate phosphoribosyltransferase NP_346248.1 1727752 R 170187 CDS NP_346249.1 15901645 931020 complement(1728767..1729333) 1 NC_003028.3 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1729333 931020 SP_1816 Streptococcus pneumoniae TIGR4 anthranilate synthase component II NP_346249.1 1728767 R 170187 CDS NP_346250.1 15901646 931018 complement(1729330..1730691) 1 NC_003028.3 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1730691 931018 SP_1817 Streptococcus pneumoniae TIGR4 anthranilate synthase component I NP_346250.1 1729330 R 170187 CDS NP_346251.1 15901647 931017 1730869..1731051 1 NC_003028.3 hypothetical protein 1731051 931017 SP_1818 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346251.1 1730869 D 170187 CDS NP_346252.1 15901648 931016 complement(1731356..1731451) 1 NC_003028.3 hypothetical protein 1731451 931016 SP_1819 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346252.1 1731356 R 170187 CDS NP_346253.1 15901649 931015 complement(1731458..1731553) 1 NC_003028.3 hypothetical protein 1731553 931015 SP_1820 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346253.1 1731458 R 170187 CDS NP_346254.1 15901650 931014 complement(1731967..1732968) 1 NC_003028.3 LacI family transcriptional regulator 1732968 931014 SP_1821 Streptococcus pneumoniae TIGR4 LacI family transcriptional regulator NP_346254.1 1731967 R 170187 CDS NP_346255.1 15901651 931013 complement(1733076..1733444) 1 NC_003028.3 similar to GP:4514548; identified by sequence similarity; hypothetical protein 1733444 931013 SP_1822 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346255.1 1733076 R 170187 CDS NP_346256.1 15901652 931012 complement(1733540..1734250) 1 NC_003028.3 MgtC/SapB family protein 1734250 931012 SP_1823 Streptococcus pneumoniae TIGR4 MgtC/SapB family protein NP_346256.1 1733540 R 170187 CDS NP_346257.1 15901653 931011 complement(1734253..1735944) 1 NC_003028.3 ABC transporter permease 1735944 931011 SP_1824 Streptococcus pneumoniae TIGR4 ABC transporter permease NP_346257.1 1734253 R 170187 CDS NP_346258.1 15901654 931010 complement(1735956..1736966) 1 NC_003028.3 ABC transporter ATP-binding protein 1736966 931010 SP_1825 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_346258.1 1735956 R 170187 CDS NP_346259.1 15901655 931009 complement(1737069..1738136) 1 NC_003028.3 ABC transporter substrate-binding protein 1738136 931009 SP_1826 Streptococcus pneumoniae TIGR4 ABC transporter substrate-binding protein NP_346259.1 1737069 R 170187 CDS NP_346260.1 15901656 931008 complement(1738161..1738820) 1 NC_003028.3 hypothetical protein 1738820 931008 SP_1827 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346260.1 1738161 R 170187 CDS NP_346261.1 15901657 931007 complement(1739000..1740010) 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR01179; UDP-glucose 4-epimerase 1740010 931007 SP_1828 Streptococcus pneumoniae TIGR4 UDP-glucose 4-epimerase NP_346261.1 1739000 R 170187 CDS NP_346262.1 15901658 931006 complement(1740023..1741498) 1 NC_003028.3 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase 1741498 931006 SP_1829 Streptococcus pneumoniae TIGR4 galactose-1-phosphate uridylyltransferase NP_346262.1 1740023 R 170187 CDS NP_346263.1 15901659 931005 complement(1741511..1742152) 1 NC_003028.3 similar to GP:4530451; identified by sequence similarity; phosphate transport system regulatory protein PhoU 1742152 931005 SP_1830 Streptococcus pneumoniae TIGR4 phosphate transport system regulatory protein PhoU NP_346263.1 1741511 R 170187 CDS NP_346264.1 15901660 931004 complement(1742210..1742692) 1 NC_003028.3 hypothetical protein 1742692 931004 SP_1831 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346264.1 1742210 R 170187 CDS NP_346265.1 15901661 931003 complement(1742753..1743049) 1 NC_003028.3 hypothetical protein 1743049 931003 SP_1832 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346265.1 1742753 R 170187 CDS NP_346266.1 15901662 931000 complement(1743033..1745159) 1 NC_003028.3 cell wall surface anchor family protein 1745159 931000 SP_1833 Streptococcus pneumoniae TIGR4 cell wall surface anchor family protein NP_346266.1 1743033 R 170187 CDS NP_346267.1 15901663 930999 complement(1745472..1745702) 1 NC_003028.3 hypothetical protein 1745702 930999 SP_1834 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346267.1 1745472 R 170187 CDS NP_346268.1 15901664 930998 complement(1745913..1746038) 1 NC_003028.3 hypothetical protein 1746038 930998 SP_1835 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346268.1 1745913 R 170187 CDS NP_346269.1 15901665 930996 1746104..1746280 1 NC_003028.3 hypothetical protein 1746280 930996 SP_1836 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346269.1 1746104 D 170187 CDS NP_346270.1 15901666 930995 complement(1746322..1747548) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01041; capsular polysaccharide biosynthesis protein 1747548 930995 SP_1837 Streptococcus pneumoniae TIGR4 capsular polysaccharide biosynthesis protein NP_346270.1 1746322 R 170187 CDS NP_346271.1 15901667 930994 complement(1747591..1748283) 1 NC_003028.3 identified by match to PFAM protein family HMM PF02397; glycosyl transferase family protein 1748283 930994 SP_1838 Streptococcus pneumoniae TIGR4 glycosyl transferase family protein NP_346271.1 1747591 R 170187 CDS NP_346272.1 15901668 930993 complement(1748456..1750207) 1 NC_003028.3 ABC transporter ATP-binding protein/permease 1750207 930993 SP_1839 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein/permease NP_346272.1 1748456 R 170187 CDS NP_346273.1 15901669 930992 complement(1750197..1751942) 1 NC_003028.3 ABC transporter ATP-binding protein/permease 1751942 930992 SP_1840 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein/permease NP_346273.1 1750197 R 170187 CDS NP_346274.1 15901670 930991 complement(1752148..1752525) 1 NC_003028.3 similar to GB:AL009126; identified by sequence similarity; hypothetical protein 1752525 930991 SP_1841 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346274.1 1752148 R 170187 CDS NP_346275.1 15901671 930990 complement(1752597..1752710) 1 NC_003028.3 hypothetical protein 1752710 930990 SP_1842 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346275.1 1752597 R 170187 CDS NP_346276.1 15901672 930989 complement(1752771..1752866) 1 NC_003028.3 hypothetical protein 1752866 930989 SP_1843 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346276.1 1752771 R 170187 CDS NP_346277.1 15901673 930988 complement(1752826..1753053) 1 NC_003028.3 hypothetical protein 1753053 930988 SP_1844 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346277.1 1752826 R 170187 CDS NP_346278.1 15901674 930987 1753187..1754014 1 NC_003028.3 identified by match to PFAM protein family HMM PF01260; exodeoxyribonuclease 1754014 930987 SP_1845 Streptococcus pneumoniae TIGR4 exodeoxyribonuclease NP_346278.1 1753187 D 170187 CDS NP_346279.1 15901675 930985 1755277..1755858 1 NC_003028.3 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 1755858 930985 SP_1847 Streptococcus pneumoniae TIGR4 xanthine phosphoribosyltransferase NP_346279.1 1755277 D 170187 CDS NP_346280.1 15901676 930984 1755858..1757120 1 NC_003028.3 xanthine permease 1757120 930984 SP_1848 Streptococcus pneumoniae TIGR4 xanthine permease NP_346280.1 1755858 D 170187 CDS NP_346281.1 15901677 930973 complement(1757170..1757631) 1 NC_003028.3 similar to GB:M14340 SP:P09359 GB:S56948 PID:153607; identified by sequence similarity; DpnD protein 1757631 930973 SP_1849 Streptococcus pneumoniae TIGR4 DpnD protein NP_346281.1 1757170 R 170187 CDS NP_346282.1 15901678 930966 complement(1757628..1758392) 1 NC_003028.3 similar to SP:P09356 GB:S56948 PID:153606; identified by sequence similarity; type II restriction endonuclease DpnI 1758392 930966 SP_1850 Streptococcus pneumoniae TIGR4 type II restriction endonuclease DpnI NP_346282.1 1757628 R 170187 CDS NP_346283.1 15901679 930982 complement(1758573..1758977) 1 NC_003028.3 hypothetical protein 1758977 930982 SP_1851 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346283.1 1758573 R 170187 CDS NP_346284.1 15901680 930983 complement(1759048..1760529) 1 NC_003028.3 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase 1760529 930983 SP_1852 Streptococcus pneumoniae TIGR4 galactose-1-phosphate uridylyltransferase NP_346284.1 1759048 R 170187 CDS NP_346285.1 15901681 930981 complement(1760548..1761726) 1 NC_003028.3 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 1761726 930981 SP_1853 Streptococcus pneumoniae TIGR4 galactokinase NP_346285.1 1760548 R 170187 CDS NP_346286.1 15901682 930980 1761891..1762898 1 NC_003028.3 galactose operon repressor 1762898 930980 SP_1854 Streptococcus pneumoniae TIGR4 galactose operon repressor NP_346286.1 1761891 D 170187 CDS NP_346287.1 15901683 930979 complement(1762944..1763981) 1 NC_003028.3 zinc-containing alcohol dehydrogenase 1763981 930979 SP_1855 Streptococcus pneumoniae TIGR4 zinc-containing alcohol dehydrogenase NP_346287.1 1762944 R 170187 CDS NP_346288.1 15901684 930978 complement(1763982..1764335) 1 NC_003028.3 MerR family transcriptional regulator 1764335 930978 SP_1856 Streptococcus pneumoniae TIGR4 MerR family transcriptional regulator NP_346288.1 1763982 R 170187 CDS NP_346289.1 15901685 930977 complement(1764579..1765478) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01545; cation efflux system protein 1765478 930977 SP_1857 Streptococcus pneumoniae TIGR4 cation efflux system protein NP_346289.1 1764579 R 170187 CDS NP_346290.1 15901686 930976 1765602..1766138 1 NC_003028.3 TetR family transcriptional regulator 1766138 930976 SP_1858 Streptococcus pneumoniae TIGR4 TetR family transcriptional regulator NP_346290.1 1765602 D 170187 CDS NP_346291.1 15901687 930975 complement(1766305..1767114) 1 NC_003028.3 similar to GB:L42023 PID:1161423 PID:1221194 PID:1205327 SP:Q57425; identified by sequence similarity; transporter 1767114 930975 SP_1859 Streptococcus pneumoniae TIGR4 transporter NP_346291.1 1766305 R 170187 CDS NP_346292.1 15901688 930974 complement(1767456..1768976) 1 NC_003028.3 choline transporter 1768976 930974 SP_1860 Streptococcus pneumoniae TIGR4 choline transporter NP_346292.1 1767456 R 170187 CDS NP_346293.1 15901689 930972 complement(1768969..1769697) 1 NC_003028.3 choline transporter 1769697 930972 SP_1861 Streptococcus pneumoniae TIGR4 choline transporter NP_346293.1 1768969 R 170187 CDS NP_346294.1 15901690 930970 complement(1769712..1770476) 1 NC_003028.3 hypothetical protein 1770476 930970 SP_1862 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346294.1 1769712 R 170187 CDS NP_346295.1 15901691 930971 complement(1770480..1770923) 1 NC_003028.3 MarR family transcriptional regulator 1770923 930971 SP_1863 Streptococcus pneumoniae TIGR4 MarR family transcriptional regulator NP_346295.1 1770480 R 170187 CDS NP_346296.1 15901692 930969 complement(1771605..1771901) 1 NC_003028.3 hypothetical protein 1771901 930969 SP_1864 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346296.1 1771605 R 170187 CDS NP_346297.1 15901693 930968 complement(1771923..1772987) 1 NC_003028.3 glutamyl-aminopeptidase 1772987 930968 SP_1865 Streptococcus pneumoniae TIGR4 glutamyl-aminopeptidase NP_346297.1 1771923 R 170187 CDS NP_346298.1 15901694 930967 1773107..1773229 1 NC_003028.3 hypothetical protein 1773229 930967 SP_1866 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346298.1 1773107 D 170187 CDS NP_346299.1 15901695 930965 1773388..1774089 1 NC_003028.3 NAD-dependent epimerase/dehydratase 1774089 930965 SP_1867 Streptococcus pneumoniae TIGR4 NAD-dependent epimerase/dehydratase NP_346299.1 1773388 D 170187 CDS NP_346300.1 15901696 930955 1774105..1774215 1 NC_003028.3 similar to PID:1652006; identified by sequence similarity; hypothetical protein 1774215 930955 SP_1868 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346300.1 1774105 D 170187 CDS NP_346301.1 15901697 930959 1774497..1775471 1 NC_003028.3 identified by match to PFAM protein family HMM PF01032; iron ABC transporter permease 1775471 930959 SP_1869 Streptococcus pneumoniae TIGR4 iron ABC transporter permease NP_346301.1 1774497 D 170187 CDS NP_346302.1 15901698 930962 1775461..1776417 1 NC_003028.3 identified by match to PFAM protein family HMM PF01032; iron ABC transporter permease 1776417 930962 SP_1870 Streptococcus pneumoniae TIGR4 iron ABC transporter permease NP_346302.1 1775461 D 170187 CDS NP_346303.1 15901699 930964 1776414..1777166 1 NC_003028.3 iron-compound ABC transporter ATP-binding protein 1777166 930964 SP_1871 Streptococcus pneumoniae TIGR4 iron-compound ABC transporter ATP-binding protein NP_346303.1 1776414 D 170187 CDS NP_346304.1 15901700 930963 1777262..1778227 1 NC_003028.3 iron-compound ABC transporter iron-compound-binding protein 1778227 930963 SP_1872 Streptococcus pneumoniae TIGR4 iron-compound ABC transporter iron-compound-binding protein NP_346304.1 1777262 D 170187 CDS NP_346305.1 15901701 930961 complement(1778452..1778694) 1 NC_003028.3 hypothetical protein 1778694 930961 SP_1873 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346305.1 1778452 R 170187 CDS NP_346306.1 15901702 930960 complement(1778694..1779416) 1 NC_003028.3 ribosomal large subunit pseudouridine synthase B 1779416 930960 SP_1874 Streptococcus pneumoniae TIGR4 ribosomal large subunit pseudouridine synthase B NP_346306.1 1778694 R 170187 CDS NP_346307.1 15901703 930958 complement(1779403..1779972) 1 NC_003028.3 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B 1779972 scpB 930958 scpB Streptococcus pneumoniae TIGR4 segregation and condensation protein B NP_346307.1 1779403 R 170187 CDS NP_346308.1 15901704 930957 complement(1779991..1780719) 1 NC_003028.3 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A 1780719 scpA 930957 scpA Streptococcus pneumoniae TIGR4 segregation and condensation protein A NP_346308.1 1779991 R 170187 CDS NP_346309.1 15901705 930956 complement(1780719..1781459) 1 NC_003028.3 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1781459 xerD 930956 xerD Streptococcus pneumoniae TIGR4 site-specific tyrosine recombinase XerD NP_346309.1 1780719 R 170187 CDS NP_346310.1 15901706 930954 complement(1781450..1781911) 1 NC_003028.3 hypothetical protein 1781911 930954 SP_1878 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346310.1 1781450 R 170187 CDS NP_346311.1 15901707 930953 complement(1781908..1782429) 1 NC_003028.3 hypothetical protein 1782429 930953 SP_1879 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346311.1 1781908 R 170187 CDS NP_346312.3 255964976 930952 complement(1782405..1783007) 1 NC_003028.3 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein 1783007 930952 SP_1880 Streptococcus pneumoniae TIGR4 deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein NP_346312.3 1782405 R 170187 CDS NP_346313.1 15901709 930951 complement(1783373..1784167) 1 NC_003028.3 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1784167 930951 SP_1881 Streptococcus pneumoniae TIGR4 glutamate racemase NP_346313.1 1783373 R 170187 CDS NP_346314.1 15901710 930950 complement(1784375..1784623) 1 NC_003028.3 hypothetical protein 1784623 930950 SP_1882 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346314.1 1784375 R 170187 CDS NP_346315.1 15901711 930949 complement(1784879..1786504) 1 NC_003028.3 dextran glucosidase DexS 1786504 930949 SP_1883 Streptococcus pneumoniae TIGR4 dextran glucosidase DexS NP_346315.1 1784879 R 170187 CDS NP_346316.1 15901712 930948 complement(1786682..1788649) 1 NC_003028.3 trehalose PTS system, IIABC components 1788649 930948 SP_1884 Streptococcus pneumoniae TIGR4 trehalose PTS system, IIABC components NP_346316.1 1786682 R 170187 CDS NP_346317.1 15901713 930947 1788834..1789544 1 NC_003028.3 trehalose operon transcriptional repressor 1789544 930947 SP_1885 Streptococcus pneumoniae TIGR4 trehalose operon transcriptional repressor NP_346317.1 1788834 D 170187 CDS NP_346318.1 15901714 930945 complement(1791100..1792026) 1 NC_003028.3 oligopeptide ABC transporter ATP-binding protein AmiF 1792026 930945 SP_1887 Streptococcus pneumoniae TIGR4 oligopeptide ABC transporter ATP-binding protein AmiF NP_346318.1 1791100 R 170187 CDS NP_346319.1 15901715 930944 complement(1792037..1793104) 1 NC_003028.3 oligopeptide ABC transporter ATP-binding protein AmiE 1793104 930944 SP_1888 Streptococcus pneumoniae TIGR4 oligopeptide ABC transporter ATP-binding protein AmiE NP_346319.1 1792037 R 170187 CDS NP_346320.1 15901716 930933 complement(1793113..1794039) 1 NC_003028.3 oligopeptide ABC transporter permease AmiD 1794039 930933 SP_1889 Streptococcus pneumoniae TIGR4 oligopeptide ABC transporter permease AmiD NP_346320.1 1793113 R 170187 CDS NP_346321.1 15901717 930941 complement(1794039..1795535) 1 NC_003028.3 oligopeptide ABC transporter permease AmiC 1795535 930941 SP_1890 Streptococcus pneumoniae TIGR4 oligopeptide ABC transporter permease AmiC NP_346321.1 1794039 R 170187 CDS NP_346322.1 15901718 930943 complement(1795602..1797581) 1 NC_003028.3 oligopeptide ABC transporter oligopeptide-binding protein AmiA 1797581 930943 SP_1891 Streptococcus pneumoniae TIGR4 oligopeptide ABC transporter oligopeptide-binding protein AmiA NP_346322.1 1795602 R 170187 CDS NP_346323.1 15901719 930942 1797708..1797875 1 NC_003028.3 hypothetical protein 1797875 930942 SP_1892 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346323.1 1797708 D 170187 CDS NP_346324.1 15901720 930940 complement(1798266..1799459) 1 NC_003028.3 hypothetical protein 1799459 930940 SP_1893 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346324.1 1798266 R 170187 CDS NP_346325.1 15901721 930939 complement(1799597..1801039) 1 NC_003028.3 sucrose phosphorylase 1801039 930939 SP_1894 Streptococcus pneumoniae TIGR4 sucrose phosphorylase NP_346325.1 1799597 R 170187 CDS NP_346326.1 15901722 930938 complement(1801397..1802233) 1 NC_003028.3 sugar ABC transporter permease 1802233 930938 SP_1895 Streptococcus pneumoniae TIGR4 sugar ABC transporter permease NP_346326.1 1801397 R 170187 CDS NP_346327.1 15901723 930937 complement(1802244..1803134) 1 NC_003028.3 sugar ABC transporter permease 1803134 930937 SP_1896 Streptococcus pneumoniae TIGR4 sugar ABC transporter permease NP_346327.1 1802244 R 170187 CDS NP_346328.1 15901724 930936 complement(1803124..1804383) 1 NC_003028.3 sugar ABC transporter substrate-binding protein 1804383 930936 SP_1897 Streptococcus pneumoniae TIGR4 sugar ABC transporter substrate-binding protein NP_346328.1 1803124 R 170187 CDS NP_346329.1 15901725 930935 complement(1804475..1806637) 1 NC_003028.3 similar to GB:M77351 SP:P27756 PID:153736; identified by sequence similarity; alpha-galactosidase 1806637 930935 SP_1898 Streptococcus pneumoniae TIGR4 alpha-galactosidase NP_346329.1 1804475 R 170187 CDS NP_346330.1 15901726 930934 1806745..1807605 1 NC_003028.3 msm operon regulatory protein 1807605 930934 SP_1899 Streptococcus pneumoniae TIGR4 msm operon regulatory protein NP_346330.1 1806745 D 170187 CDS NP_346331.1 15901727 930932 1807602..1808537 1 NC_003028.3 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1808537 930932 SP_1900 Streptococcus pneumoniae TIGR4 biotin--protein ligase NP_346331.1 1807602 D 170187 CDS NP_346332.1 15901728 932014 complement(1815445..1816755) 1 NC_003028.3 RNA methyltransferase 1816755 932014 SP_1901 Streptococcus pneumoniae TIGR4 RNA methyltransferase NP_346332.1 1815445 R 170187 CDS NP_346333.1 15901729 932013 1816838..1817614 1 NC_003028.3 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1817614 recX 932013 recX Streptococcus pneumoniae TIGR4 recombination regulator RecX NP_346333.1 1816838 D 170187 CDS NP_346334.1 15901730 929755 1817703..1818236 1 NC_003028.3 hypothetical protein 1818236 929755 SP_1903 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346334.1 1817703 D 170187 CDS NP_346335.1 15901731 929847 complement(1818590..1818796) 1 NC_003028.3 hypothetical protein 1818796 929847 SP_1904 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346335.1 1818590 R 170187 CDS NP_346336.1 15901732 931987 complement(1820362..1821984) 1 NC_003028.3 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 1821984 groEL 931987 groEL Streptococcus pneumoniae TIGR4 molecular chaperone GroEL NP_346336.1 1820362 R 170187 CDS NP_346337.1 15901733 929944 complement(1822000..1822284) 1 NC_003028.3 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1822284 groES 929944 groES Streptococcus pneumoniae TIGR4 co-chaperonin GroES NP_346337.1 1822000 R 170187 CDS YP_873936.1 118090033 930149 complement(1822440..1822835) 1 NC_003028.3 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1822835 930149 SP_1908 Streptococcus pneumoniae TIGR4 single-stranded DNA-binding protein YP_873936.1 1822440 R 170187 CDS NP_346338.1 15901734 929802 complement(1822913..1823674) 1 NC_003028.3 short chain dehydrogenase/reductase family oxidoreductase 1823674 929802 SP_1909 Streptococcus pneumoniae TIGR4 short chain dehydrogenase/reductase family oxidoreductase NP_346338.1 1822913 R 170187 CDS NP_346339.1 15901735 930140 complement(1823716..1824342) 1 NC_003028.3 hypothetical protein 1824342 930140 SP_1910 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346339.1 1823716 R 170187 CDS NP_346340.1 15901736 930223 complement(1824358..1824675) 1 NC_003028.3 similar to SP:P29449 PID:20047; identified by sequence similarity; thioredoxin 1824675 930223 SP_1911 Streptococcus pneumoniae TIGR4 thioredoxin NP_346340.1 1824358 R 170187 CDS NP_346341.1 15901737 931950 complement(1824672..1824971) 1 NC_003028.3 hypothetical protein 1824971 931950 SP_1912 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346341.1 1824672 R 170187 CDS NP_346342.1 15901738 930527 complement(1825660..1826334) 1 NC_003028.3 hypothetical protein 1826334 930527 SP_1914 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346342.1 1825660 R 170187 CDS NP_346343.1 15901739 929971 complement(1826340..1826789) 1 NC_003028.3 hypothetical protein 1826789 929971 SP_1915 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346343.1 1826340 R 170187 CDS NP_346344.1 15901740 931899 complement(1826900..1827403) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01569; PAP2 family protein 1827403 931899 SP_1916 Streptococcus pneumoniae TIGR4 PAP2 family protein NP_346344.1 1826900 R 170187 CDS NP_346345.1 15901741 930462 complement(1827400..1827762) 1 NC_003028.3 hypothetical protein 1827762 930462 SP_1917 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346345.1 1827400 R 170187 CDS NP_346346.1 15901742 931990 complement(1827828..1828859) 1 NC_003028.3 ABC transporter ATP-binding protein 1828859 931990 SP_1918 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_346346.1 1827828 R 170187 CDS NP_346347.1 15901743 930135 complement(1828866..1829687) 1 NC_003028.3 ABC transporter permease 1829687 930135 SP_1919 Streptococcus pneumoniae TIGR4 ABC transporter permease NP_346347.1 1828866 R 170187 CDS NP_346348.1 15901744 930096 complement(1829726..1830175) 1 NC_003028.3 MarR family transcriptional regulator 1830175 930096 SP_1920 Streptococcus pneumoniae TIGR4 MarR family transcriptional regulator NP_346348.1 1829726 R 170187 CDS NP_346349.1 15901745 931844 complement(1830188..1830283) 1 NC_003028.3 hypothetical protein 1830283 931844 SP_1921 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346349.1 1830188 R 170187 CDS NP_346350.1 15901746 930148 complement(1830299..1831015) 1 NC_003028.3 hypothetical protein 1831015 930148 SP_1922 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346350.1 1830299 R 170187 CDS NP_346351.1 15901747 931915 complement(1831896..1833311) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01289; pneumolysin 1833311 931915 SP_1923 Streptococcus pneumoniae TIGR4 pneumolysin NP_346351.1 1831896 R 170187 CDS NP_346352.1 15901748 929813 complement(1833322..1833732) 1 NC_003028.3 hypothetical protein 1833732 929813 SP_1924 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346352.1 1833322 R 170187 CDS NP_346353.1 15901749 931877 complement(1833725..1834333) 1 NC_003028.3 hypothetical protein 1834333 931877 SP_1925 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346353.1 1833725 R 170187 CDS NP_346354.1 15901750 930085 complement(1834346..1834822) 1 NC_003028.3 hypothetical protein 1834822 930085 SP_1926 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346354.1 1834346 R 170187 CDS NP_346355.1 15901751 931475 1834929..1835318 1 NC_003028.3 similar to PID:763133; identified by sequence similarity; IS1381 transposase protein A 1835318 931475 SP_1927 Streptococcus pneumoniae TIGR4 IS1381 transposase protein A NP_346355.1 1834929 D 170187 CDS NP_346356.1 15901752 929822 1835344..1835733 1 NC_003028.3 similar to PID:763133; identified by sequence similarity; IS1381 transposase protein B 1835733 929822 SP_1928 Streptococcus pneumoniae TIGR4 IS1381 transposase protein B NP_346356.1 1835344 D 170187 CDS NP_346357.1 15901753 931880 complement(1836144..1836242) 1 NC_003028.3 hypothetical protein 1836242 931880 SP_1929 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346357.1 1836144 R 170187 CDS NP_346358.1 15901754 930313 complement(1836471..1836731) 1 NC_003028.3 hypothetical protein 1836731 930313 SP_1930 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346358.1 1836471 R 170187 CDS NP_346359.1 15901755 930543 complement(1836790..1837344) 1 NC_003028.3 hypothetical protein 1837344 930543 SP_1931 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346359.1 1836790 R 170187 CDS NP_346360.1 15901756 930252 complement(1837331..1837429) 1 NC_003028.3 hypothetical protein 1837429 930252 SP_1932 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346360.1 1837331 R 170187 CDS NP_346361.1 15901757 930458 complement(1837532..1838326) 1 NC_003028.3 hypothetical protein 1838326 930458 SP_1933 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346361.1 1837532 R 170187 CDS NP_346362.1 15901758 931989 complement(1838734..1839159) 1 NC_003028.3 hypothetical protein 1839159 931989 SP_1934 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346362.1 1838734 R 170187 CDS NP_346363.1 15901759 931834 complement(1839288..1839647) 1 NC_003028.3 hypothetical protein 1839647 931834 SP_1935 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346363.1 1839288 R 170187 CDS NP_346364.1 15901760 930503 complement(1839886..1840047) 1 NC_003028.3 similar to GB:M77223 PID:455322; identified by sequence similarity; type II restriction-modification system regulatory protein 1840047 930503 SP_1936 Streptococcus pneumoniae TIGR4 type II restriction-modification system regulatory protein NP_346364.1 1839886 R 170187 CDS NP_346365.1 15901761 931994 complement(1840405..1841361) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01510; autolysin 1841361 931994 SP_1937 Streptococcus pneumoniae TIGR4 autolysin NP_346365.1 1840405 R 170187 CDS NP_346366.1 15901762 930339 complement(1841489..1841602) 1 NC_003028.3 hypothetical protein 1841602 930339 SP_1938 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346366.1 1841489 R 170187 CDS NP_346367.1 15901763 931984 complement(1841737..1843107) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01554; MATE efflux family protein DinF 1843107 931984 SP_1939 Streptococcus pneumoniae TIGR4 MATE efflux family protein DinF NP_346367.1 1841737 R 170187 CDS NP_346368.1 15901764 929833 complement(1843413..1844579) 1 NC_003028.3 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1844579 recA 929833 recA Streptococcus pneumoniae TIGR4 recombinase A NP_346368.1 1843413 R 170187 CDS NP_346369.1 15901765 931883 complement(1844634..1845890) 1 NC_003028.3 competence damage-inducible protein A 1845890 931883 SP_1941 Streptococcus pneumoniae TIGR4 competence damage-inducible protein A NP_346369.1 1844634 R 170187 CDS NP_346370.1 15901766 930155 complement(1845975..1846991) 1 NC_003028.3 transcriptional regulator 1846991 930155 SP_1942 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_346370.1 1845975 R 170187 CDS NP_346371.1 15901767 931925 complement(1846999..1847517) 1 NC_003028.3 acetyltransferase 1847517 931925 SP_1943 Streptococcus pneumoniae TIGR4 acetyltransferase NP_346371.1 1846999 R 170187 CDS NP_346372.1 15901768 929943 complement(1847507..1847950) 1 NC_003028.3 hypothetical protein 1847950 929943 SP_1944 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346372.1 1847507 R 170187 CDS NP_346373.1 15901769 931898 complement(1848036..1848656) 1 NC_003028.3 hypothetical protein 1848656 931898 SP_1945 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346373.1 1848036 R 170187 CDS NP_346374.1 15901770 930492 complement(1849039..1849902) 1 NC_003028.3 transcriptional regulator PlcR 1849902 930492 SP_1946 Streptococcus pneumoniae TIGR4 transcriptional regulator PlcR NP_346374.1 1849039 R 170187 CDS NP_346375.1 15901771 931992 1850094..1850264 1 NC_003028.3 hypothetical protein 1850264 931992 SP_1947 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346375.1 1850094 D 170187 CDS NP_346376.1 15901772 930068 1850367..1850591 1 NC_003028.3 similar to PID:559859; identified by sequence similarity; hypothetical protein 1850591 930068 SP_1948 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346376.1 1850367 D 170187 CDS NP_346377.1 15901773 929914 1850598..1850786 1 NC_003028.3 hypothetical protein 1850786 929914 SP_1949 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346377.1 1850598 D 170187 CDS NP_346378.1 15901774 930104 1850902..1853892 1 NC_003028.3 similar to SP:P37609 PID:433322; identified by sequence similarity; bacteriocin formation protein 1853892 930104 SP_1950 Streptococcus pneumoniae TIGR4 bacteriocin formation protein NP_346378.1 1850902 D 170187 CDS NP_346379.1 15901775 931919 1854242..1854946 1 NC_003028.3 hypothetical protein 1854946 931919 SP_1951 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346379.1 1854242 D 170187 CDS NP_346380.1 15901776 930283 1854927..1855856 1 NC_003028.3 hypothetical protein 1855856 930283 SP_1952 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346380.1 1854927 D 170187 CDS NP_346381.1 15901777 931975 1855865..1857961 1 NC_003028.3 toxin secretion ABC transporter ATP-binding protein/permease 1857961 931975 SP_1953 Streptococcus pneumoniae TIGR4 toxin secretion ABC transporter ATP-binding protein/permease NP_346381.1 1855865 D 170187 CDS YP_873937.1 118090034 930312 1857994..1859397 1 NC_003028.3 serine protease subtilase 1859397 930312 SP_1954 Streptococcus pneumoniae TIGR4 serine protease subtilase YP_873937.1 1857994 D 170187 CDS NP_346382.1 15901778 930113 1859412..1859723 1 NC_003028.3 hypothetical protein 1859723 930113 SP_1955 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346382.1 1859412 D 170187 CDS NP_346383.1 15901779 931916 1859774..1860541 1 NC_003028.3 hypothetical protein 1860541 931916 SP_1956 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346383.1 1859774 D 170187 CDS NP_346384.1 15901780 929998 1860543..1861175 1 NC_003028.3 ABC transporter ATP-binding protein 1861175 929998 SP_1957 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_346384.1 1860543 D 170187 CDS NP_346385.1 15901781 931900 1861333..1861494 1 NC_003028.3 hypothetical protein 1861494 931900 SP_1958 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346385.1 1861333 D 170187 CDS NP_346386.1 15901782 929787 complement(1862121..1862534) 1 NC_003028.3 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1862534 ndk 929787 ndk Streptococcus pneumoniae TIGR4 nucleoside diphosphate kinase NP_346386.1 1862121 R 170187 CDS NP_346387.1 15901783 931871 complement(1862645..1866322) 1 NC_003028.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 1866322 931871 SP_1960 Streptococcus pneumoniae TIGR4 DNA-directed RNA polymerase subunit beta' NP_346387.1 1862645 R 170187 CDS NP_346388.1 15901784 930094 complement(1866355..1869966) 1 NC_003028.3 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1869966 rpoB 930094 rpoB Streptococcus pneumoniae TIGR4 DNA-directed RNA polymerase subunit beta NP_346388.1 1866355 R 170187 CDS NP_346389.1 15901785 929910 1870422..1870529 1 NC_003028.3 hypothetical protein 1870529 929910 SP_1962 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346389.1 1870422 D 170187 CDS NP_346390.1 15901786 931894 complement(1870650..1871981) 1 NC_003028.3 hypothetical protein 1871981 931894 SP_1963 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346390.1 1870650 R 170187 CDS NP_346391.1 15901787 929957 complement(1872210..1873034) 1 NC_003028.3 DNA-entry nuclease 1873034 929957 SP_1964 Streptococcus pneumoniae TIGR4 DNA-entry nuclease NP_346391.1 1872210 R 170187 CDS NP_346392.1 15901788 929832 complement(1873073..1873279) 1 NC_003028.3 hypothetical protein 1873279 929832 SP_1965 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346392.1 1873073 R 170187 CDS NP_346393.1 15901789 931882 complement(1873254..1874537) 1 NC_003028.3 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1874537 931882 SP_1966 Streptococcus pneumoniae TIGR4 UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_346393.1 1873254 R 170187 CDS NP_346394.1 15901790 929799 complement(1874849..1875886) 1 NC_003028.3 hypothetical protein 1875886 929799 SP_1967 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346394.1 1874849 R 170187 CDS NP_346395.1 15901791 931873 complement(1875870..1876358) 1 NC_003028.3 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1876358 coaD 931873 coaD Streptococcus pneumoniae TIGR4 phosphopantetheine adenylyltransferase NP_346395.1 1875870 R 170187 CDS NP_346396.1 15901792 929836 complement(1876348..1876887) 1 NC_003028.3 type II DNA modification methyltransferase 1876887 929836 SP_1969 Streptococcus pneumoniae TIGR4 type II DNA modification methyltransferase NP_346396.1 1876348 R 170187 CDS NP_346397.1 15901793 931885 complement(1876952..1877944) 1 NC_003028.3 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 1877944 931885 SP_1970 Streptococcus pneumoniae TIGR4 asparagine synthetase AsnA NP_346397.1 1876952 R 170187 CDS NP_346398.1 15901794 929783 1877918..1878082 1 NC_003028.3 hypothetical protein 1878082 929783 SP_1971 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346398.1 1877918 D 170187 CDS NP_346399.1 15901795 930066 complement(1878056..1878763) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01027; hypothetical protein 1878763 930066 SP_1972 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346399.1 1878056 R 170187 CDS NP_346400.1 15901796 931909 complement(1878795..1879535) 1 NC_003028.3 spoU rRNA methylase 1879535 931909 SP_1973 Streptococcus pneumoniae TIGR4 spoU rRNA methylase NP_346400.1 1878795 R 170187 CDS NP_346401.1 15901797 929925 1879569..1879847 1 NC_003028.3 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1879847 929925 SP_1974 Streptococcus pneumoniae TIGR4 acylphosphatase NP_346401.1 1879569 D 170187 CDS NP_346402.1 15901798 929760 1879925..1880851 1 NC_003028.3 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor 1880851 929760 SP_1975 Streptococcus pneumoniae TIGR4 OxaA-like protein precursor NP_346402.1 1879925 D 170187 CDS NP_346403.1 15901799 929784 complement(1880926..1881720) 1 NC_003028.3 identified by match to PFAM protein family HMM PF02143; pyruvate formate-lyase-activating enzyme 1881720 929784 SP_1976 Streptococcus pneumoniae TIGR4 pyruvate formate-lyase-activating enzyme NP_346403.1 1880926 R 170187 CDS NP_346404.1 15901800 929803 1881768..1881872 1 NC_003028.3 hypothetical protein 1881872 929803 SP_1977 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346404.1 1881768 D 170187 CDS NP_346405.1 15901801 931875 complement(1881846..1883096) 1 NC_003028.3 diaminopimelate decarboxylase 1883096 931875 SP_1978 Streptococcus pneumoniae TIGR4 diaminopimelate decarboxylase NP_346405.1 1881846 R 170187 CDS NP_346406.1 15901802 929904 complement(1883163..1883990) 1 NC_003028.3 pur operon repressor 1883990 929904 SP_1979 Streptococcus pneumoniae TIGR4 pur operon repressor NP_346406.1 1883163 R 170187 CDS NP_346407.1 15901803 931892 complement(1884257..1885183) 1 NC_003028.3 cmp-binding-factor 1 1885183 931892 SP_1980 Streptococcus pneumoniae TIGR4 cmp-binding-factor 1 NP_346407.1 1884257 R 170187 CDS NP_346408.1 15901804 929946 complement(1885188..1886444) 1 NC_003028.3 hypothetical protein 1886444 929946 SP_1981 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346408.1 1885188 R 170187 CDS NP_346409.1 15901805 929862 complement(1886446..1887129) 1 NC_003028.3 hypothetical protein 1887129 929862 SP_1982 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346409.1 1886446 R 170187 CDS NP_346410.1 15901806 931887 complement(1887071..1887727) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00834; ribulose-phosphate 3-epimerase 1887727 931887 SP_1983 Streptococcus pneumoniae TIGR4 ribulose-phosphate 3-epimerase NP_346410.1 1887071 R 170187 CDS NP_346411.1 15901807 930526 complement(1887738..1888616) 1 NC_003028.3 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 1888616 930526 SP_1984 Streptococcus pneumoniae TIGR4 ribosome-associated GTPase NP_346411.1 1887738 R 170187 CDS NP_346412.1 15901808 929819 complement(1888618..1889457) 1 NC_003028.3 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1889457 ksgA 929819 ksgA Streptococcus pneumoniae TIGR4 dimethyladenosine transferase NP_346412.1 1888618 R 170187 CDS NP_346413.1 15901809 931879 complement(1889621..1889935) 1 NC_003028.3 hypothetical protein 1889935 931879 SP_1986 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346413.1 1889621 R 170187 CDS NP_346414.1 15901810 929919 complement(1889922..1890563) 1 NC_003028.3 ABC transporter ATP-binding protein 1890563 929919 SP_1987 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_346414.1 1889922 R 170187 CDS NP_346415.1 15901811 931896 complement(1890565..1892598) 1 NC_003028.3 similar to GP:3355783; identified by sequence similarity; immunity protein 1892598 931896 SP_1988 Streptococcus pneumoniae TIGR4 immunity protein NP_346415.1 1890565 R 170187 CDS NP_346416.1 15901812 929751 complement(1892864..1893763) 1 NC_003028.3 transcriptional regulator PlcR 1893763 929751 SP_1989 Streptococcus pneumoniae TIGR4 transcriptional regulator PlcR NP_346416.1 1892864 R 170187 CDS NP_346417.1 15901813 930004 complement(1893835..1894395) 1 NC_003028.3 primase-like protein 1894395 930004 SP_1990 Streptococcus pneumoniae TIGR4 primase-like protein NP_346417.1 1893835 R 170187 CDS NP_346418.1 15901814 931903 complement(1894395..1895168) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01026; hydrolase 1895168 931903 SP_1991 Streptococcus pneumoniae TIGR4 hydrolase NP_346418.1 1894395 R 170187 CDS NP_346419.1 15901815 930321 complement(1895473..1896138) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00746; cell wall surface anchor family protein 1896138 930321 SP_1992 Streptococcus pneumoniae TIGR4 cell wall surface anchor family protein NP_346419.1 1895473 R 170187 CDS NP_346420.1 15901816 930208 complement(1896650..1896784) 1 NC_003028.3 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 1896784 rpmH 930208 rpmH Streptococcus pneumoniae TIGR4 50S ribosomal protein L34 NP_346420.1 1896650 R 170187 CDS NP_346421.1 15901817 932041 complement(1896929..1898143) 1 NC_003028.3 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 1898143 932041 SP_1994 Streptococcus pneumoniae TIGR4 aminotransferase NP_346421.1 1896929 R 170187 CDS NP_346422.1 15901818 930164 complement(1898183..1898593) 1 NC_003028.3 hypothetical protein 1898593 930164 SP_1995 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346422.1 1898183 R 170187 CDS NP_346423.1 15901819 931917 1898755..1899207 1 NC_003028.3 identified by match to PFAM protein family HMM PF00582; universal stress protein 1899207 931917 SP_1996 Streptococcus pneumoniae TIGR4 universal stress protein NP_346423.1 1898755 D 170187 CDS NP_346424.1 15901820 929913 complement(1899242..1900630) 1 NC_003028.3 Cof family protein 1900630 929913 SP_1997 Streptococcus pneumoniae TIGR4 Cof family protein NP_346424.1 1899242 R 170187 CDS NP_346425.1 15901821 931895 1900696..1901658 1 NC_003028.3 identified by match to PFAM protein family HMM PF00710; L-asparaginase 1901658 931895 SP_1998 Streptococcus pneumoniae TIGR4 L-asparaginase NP_346425.1 1900696 D 170187 CDS NP_346426.1 15901822 930480 complement(1902314..1903324) 1 NC_003028.3 catabolite control protein A 1903324 930480 SP_1999 Streptococcus pneumoniae TIGR4 catabolite control protein A NP_346426.1 1902314 R 170187 CDS NP_346427.1 15901823 931991 complement(1903749..1904348) 1 NC_003028.3 DNA-binding response regulator 1904348 931991 SP_2000 Streptococcus pneumoniae TIGR4 DNA-binding response regulator NP_346427.1 1903749 R 170187 CDS NP_346428.1 15901824 930338 complement(1904349..1905446) 1 NC_003028.3 sensor histidine kinase 1905446 930338 SP_2001 Streptococcus pneumoniae TIGR4 sensor histidine kinase NP_346428.1 1904349 R 170187 CDS NP_346429.1 15901825 931986 complement(1905446..1906183) 1 NC_003028.3 hypothetical protein 1906183 931986 SP_2002 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346429.1 1905446 R 170187 CDS NP_346430.1 15901826 929970 complement(1906185..1907069) 1 NC_003028.3 ABC transporter ATP-binding protein 1907069 929970 SP_2003 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_346430.1 1906185 R 170187 CDS NP_346431.1 15901827 931901 complement(1907056..1907250) 1 NC_003028.3 hypothetical protein 1907250 931901 SP_2004 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346431.1 1907056 R 170187 CDS NP_346432.1 15901828 930381 complement(1907247..1907378) 1 NC_003028.3 hypothetical protein 1907378 930381 SP_2005 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346432.1 1907247 R 170187 CDS NP_346433.1 15901829 932002 complement(1914134..1914613) 1 NC_003028.3 similar to GP:5739312; identified by sequence similarity; transcriptional regulator ComX2 1914613 932002 SP_2006 Streptococcus pneumoniae TIGR4 transcriptional regulator ComX2 NP_346433.1 1914134 R 170187 CDS NP_346434.1 15901830 932003 complement(1914735..1915271) 1 NC_003028.3 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 1915271 nusG 932003 nusG Streptococcus pneumoniae TIGR4 transcription antitermination protein NusG NP_346434.1 1914735 R 170187 CDS NP_346435.1 15901831 932007 complement(1915326..1915502) 1 NC_003028.3 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1915502 secE 932007 secE Streptococcus pneumoniae TIGR4 preprotein translocase subunit SecE NP_346435.1 1915326 R 170187 CDS NP_346436.1 15901832 932006 complement(1915512..1915664) 1 NC_003028.3 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 1915664 rpmG 932006 rpmG Streptococcus pneumoniae TIGR4 50S ribosomal protein L33 NP_346436.1 1915512 R 170187 CDS NP_346437.1 15901833 932011 complement(1915717..1917912) 1 NC_003028.3 penicillin-binding protein 2A 1917912 932011 SP_2010 Streptococcus pneumoniae TIGR4 penicillin-binding protein 2A NP_346437.1 1915717 R 170187 CDS NP_346438.1 15901834 932008 1917999..1918874 1 NC_003028.3 ribosomal large subunit pseudouridine synthase D 1918874 932008 SP_2011 Streptococcus pneumoniae TIGR4 ribosomal large subunit pseudouridine synthase D NP_346438.1 1917999 D 170187 CDS NP_346439.1 15901835 932009 complement(1918942..1919949) 1 NC_003028.3 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase 1919949 932009 SP_2012 Streptococcus pneumoniae TIGR4 glyceraldehyde-3-phosphate dehydrogenase NP_346439.1 1918942 R 170187 CDS NP_346440.1 15901836 932037 complement(1920126..1921106) 1 NC_003028.3 hypothetical protein 1921106 932037 SP_2013 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346440.1 1920126 R 170187 CDS NP_346441.1 15901837 932039 complement(1921149..1921487) 1 NC_003028.3 IS630-Spn1, transposase Orf2 1921487 932039 SP_2014 Streptococcus pneumoniae TIGR4 IS630-Spn1, transposase Orf2 NP_346441.1 1921149 R 170187 CDS NP_346442.1 15901838 931996 complement(1921596..1922012) 1 NC_003028.3 IS630-Spn1, transposase Orf1 1922012 931996 SP_2015 Streptococcus pneumoniae TIGR4 IS630-Spn1, transposase Orf1 NP_346442.1 1921596 R 170187 CDS NP_346443.1 15901839 932040 complement(1922125..1922997) 1 NC_003028.3 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1922997 932040 SP_2016 Streptococcus pneumoniae TIGR4 nicotinate-nucleotide pyrophosphorylase NP_346443.1 1922125 R 170187 CDS NP_346444.1 15901840 932016 1923234..1924544 1 NC_003028.3 hypothetical protein 1924544 932016 SP_2017 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346444.1 1923234 D 170187 CDS NP_346445.1 15901841 932018 complement(1925563..1926291) 1 NC_003028.3 GntR family transcriptional regulator 1926291 932018 SP_2020 Streptococcus pneumoniae TIGR4 GntR family transcriptional regulator NP_346445.1 1925563 R 170187 CDS NP_346446.1 15901842 932019 1926449..1927858 1 NC_003028.3 glycosyl hydrolase 1927858 932019 SP_2021 Streptococcus pneumoniae TIGR4 glycosyl hydrolase NP_346446.1 1926449 D 170187 CDS NP_346447.1 15901843 932024 1927876..1929171 1 NC_003028.3 PTS system transporter subunit IIC 1929171 932024 SP_2022 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIC NP_346447.1 1927876 D 170187 CDS NP_346448.1 15901844 932022 1929176..1929484 1 NC_003028.3 PTS system transporter subunit IIB 1929484 932022 SP_2023 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIB NP_346448.1 1929176 D 170187 CDS NP_346449.1 15901845 932023 1929463..1929789 1 NC_003028.3 PTS system transporter subunit IIA 1929789 932023 SP_2024 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIA NP_346449.1 1929463 D 170187 CDS NP_346450.1 15901846 932027 1930261..1930356 1 NC_003028.3 hypothetical protein 1930356 932027 SP_2025 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346450.1 1930261 D 170187 CDS NP_346451.1 15901847 932025 complement(1930775..1933426) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00465; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1933426 932025 SP_2026 Streptococcus pneumoniae TIGR4 bifunctional acetaldehyde-CoA/alcohol dehydrogenase NP_346451.1 1930775 R 170187 CDS NP_346452.1 15901848 932026 complement(1933726..1934136) 1 NC_003028.3 hypothetical protein 1934136 932026 SP_2027 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346452.1 1933726 R 170187 CDS NP_346453.1 15901849 932030 complement(1934138..1934566) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01451; phosphotyrosine protein phosphatase 1934566 932030 SP_2028 Streptococcus pneumoniae TIGR4 phosphotyrosine protein phosphatase NP_346453.1 1934138 R 170187 CDS NP_346454.1 15901850 932028 complement(1934612..1934911) 1 NC_003028.3 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 1934911 yajC 932028 yajC Streptococcus pneumoniae TIGR4 preprotein translocase subunit YajC NP_346454.1 1934612 R 170187 CDS NP_346455.1 15901851 932029 complement(1935028..1937004) 1 NC_003028.3 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1937004 932029 SP_2030 Streptococcus pneumoniae TIGR4 transketolase NP_346455.1 1935028 R 170187 CDS NP_346456.1 15901852 932033 complement(1937118..1938209) 1 NC_003028.3 L-ascorbate 6-phosphate lactonase 1938209 932033 SP_2031 Streptococcus pneumoniae TIGR4 L-ascorbate 6-phosphate lactonase NP_346456.1 1937118 R 170187 CDS NP_346457.1 15901853 932031 complement(1938321..1939994) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00874; BglG family transcriptional regulator 1939994 932031 SP_2032 Streptococcus pneumoniae TIGR4 BglG family transcriptional regulator NP_346457.1 1938321 R 170187 CDS NP_346458.1 15901854 932032 complement(1940173..1940856) 1 NC_003028.3 catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase 1940856 araD 932032 araD Streptococcus pneumoniae TIGR4 L-ribulose-5-phosphate 4-epimerase NP_346458.1 1940173 R 170187 CDS NP_346459.1 15901855 932036 complement(1940879..1941742) 1 NC_003028.3 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase 1941742 932036 SP_2034 Streptococcus pneumoniae TIGR4 L-xylulose 5-phosphate 3-epimerase NP_346459.1 1940879 R 170187 CDS NP_346460.1 15901856 932034 complement(1941746..1942411) 1 NC_003028.3 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 1942411 ulaD 932034 ulaD Streptococcus pneumoniae TIGR4 3-keto-L-gulonate-6-phosphate decarboxylase NP_346460.1 1941746 R 170187 CDS NP_346461.1 15901857 932035 complement(1942428..1942913) 1 NC_003028.3 PTS system transporter subunit IIA 1942913 932035 SP_2036 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIA NP_346461.1 1942428 R 170187 CDS NP_346462.1 15901858 931995 complement(1942990..1943271) 1 NC_003028.3 similar to GB:U14003 SP:P39302 PID:537035 GB:U00096 PID:1790638; identified by sequence similarity; PTS system transporter subunit IIB 1943271 931995 SP_2037 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIB NP_346462.1 1942990 R 170187 CDS NP_346463.1 15901859 932038 complement(1943294..1944751) 1 NC_003028.3 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 1944751 ulaA 932038 ulaA Streptococcus pneumoniae TIGR4 PTS system ascorbate-specific transporter subunit IIC NP_346463.1 1943294 R 170187 CDS NP_346464.1 15901860 932042 complement(1944882..1945505) 1 NC_003028.3 hypothetical protein 1945505 932042 SP_2039 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346464.1 1944882 R 170187 CDS NP_346465.1 15901861 932015 complement(1945556..1946542) 1 NC_003028.3 jag protein 1946542 932015 SP_2040 Streptococcus pneumoniae TIGR4 jag protein NP_346465.1 1945556 R 170187 CDS NP_346466.1 15901862 932020 complement(1946561..1947385) 1 NC_003028.3 SpoIIIJ family protein 1947385 932020 SP_2041 Streptococcus pneumoniae TIGR4 SpoIIIJ family protein NP_346466.1 1946561 R 170187 CDS NP_346467.1 15901863 932005 complement(1947360..1947731) 1 NC_003028.3 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 1947731 rnpA 932005 rnpA Streptococcus pneumoniae TIGR4 ribonuclease P NP_346467.1 1947360 R 170187 CDS NP_346468.1 15901864 932000 complement(1947748..1947879) 1 NC_003028.3 hypothetical protein 1947879 932000 SP_2043 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346468.1 1947748 R 170187 CDS NP_346469.1 15901865 932010 complement(1947880..1949070) 1 NC_003028.3 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 1949070 932010 SP_2044 Streptococcus pneumoniae TIGR4 acetate kinase NP_346469.1 1947880 R 170187 CDS NP_346470.1 15901866 930307 complement(1949121..1950074) 1 NC_003028.3 hypothetical protein 1950074 930307 SP_2045 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346470.1 1949121 R 170187 CDS NP_346471.1 15901867 930318 complement(1950866..1951279) 1 NC_003028.3 similar to GP:5103043; identified by sequence similarity; hypothetical protein 1951279 930318 SP_2047 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346471.1 1950866 R 170187 CDS NP_346472.1 15901868 930322 complement(1951257..1951718) 1 NC_003028.3 hypothetical protein 1951718 930322 SP_2048 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346472.1 1951257 R 170187 CDS NP_346473.1 15901869 931980 complement(1951681..1951941) 1 NC_003028.3 hypothetical protein 1951941 931980 SP_2049 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346473.1 1951681 R 170187 CDS NP_346474.1 15901870 930320 complement(1951946..1952350) 1 NC_003028.3 similar to GP:3211751; identified by sequence similarity; competence protein CglD 1952350 930320 SP_2050 Streptococcus pneumoniae TIGR4 competence protein CglD NP_346474.1 1951946 R 170187 CDS NP_346475.1 15901871 930319 complement(1952343..1952669) 1 NC_003028.3 similar to GP:3211750; identified by sequence similarity; competence protein CglC 1952669 930319 SP_2051 Streptococcus pneumoniae TIGR4 competence protein CglC NP_346475.1 1952343 R 170187 CDS NP_346476.1 15901872 931979 complement(1952671..1953543) 1 NC_003028.3 competence protein CglB 1953543 931979 SP_2052 Streptococcus pneumoniae TIGR4 competence protein CglB NP_346476.1 1952671 R 170187 CDS NP_346477.1 15901873 930328 complement(1953635..1954576) 1 NC_003028.3 competence protein CglA 1954576 930328 SP_2053 Streptococcus pneumoniae TIGR4 competence protein CglA NP_346477.1 1953635 R 170187 CDS NP_346478.1 15901874 930329 complement(1954652..1955023) 1 NC_003028.3 hypothetical protein 1955023 930329 SP_2054 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346478.1 1954652 R 170187 CDS NP_346479.1 15901875 931982 complement(1955168..1956226) 1 NC_003028.3 zinc-containing alcohol dehydrogenase 1956226 931982 SP_2055 Streptococcus pneumoniae TIGR4 zinc-containing alcohol dehydrogenase NP_346479.1 1955168 R 170187 CDS NP_346480.1 15901876 930327 complement(1956389..1957540) 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00221; N-acetylglucosamine-6-phosphate deacetylase 1957540 930327 SP_2056 Streptococcus pneumoniae TIGR4 N-acetylglucosamine-6-phosphate deacetylase NP_346480.1 1956389 R 170187 CDS NP_346481.1 15901877 930324 complement(1957693..1959510) 1 NC_003028.3 hypothetical protein 1959510 930324 SP_2057 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346481.1 1957693 R 170187 CDS NP_346482.1 15901878 931981 complement(1959608..1960750) 1 NC_003028.3 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 1960750 tgt 931981 tgt Streptococcus pneumoniae TIGR4 queuine tRNA-ribosyltransferase NP_346482.1 1959608 R 170187 CDS NP_346483.1 15901879 930317 1960880..1961737 1 NC_003028.3 hypothetical protein 1961737 930317 SP_2059 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346483.1 1960880 D 170187 CDS NP_346484.1 15901880 931978 complement(1961765..1962409) 1 NC_003028.3 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 1962409 931978 SP_2060 Streptococcus pneumoniae TIGR4 pyrrolidone-carboxylate peptidase NP_346484.1 1961765 R 170187 CDS NP_346485.1 15901881 930314 complement(1962516..1962875) 1 NC_003028.3 hypothetical protein 1962875 930314 SP_2061 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346485.1 1962516 R 170187 CDS NP_346486.1 15901882 930311 complement(1962886..1963311) 1 NC_003028.3 MarR family transcriptional regulator 1963311 930311 SP_2062 Streptococcus pneumoniae TIGR4 MarR family transcriptional regulator NP_346486.1 1962886 R 170187 CDS YP_873938.1 118090038 930310 complement(1963634..1964746) 1 NC_003028.3 LysM domain-containing protein 1964746 930310 SP_2063 Streptococcus pneumoniae TIGR4 LysM domain-containing protein YP_873938.1 1963634 R 170187 CDS NP_346487.1 15901883 930304 complement(1964912..1965532) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00702; HAD superfamily hydrolase 1965532 930304 SP_2064 Streptococcus pneumoniae TIGR4 HAD superfamily hydrolase NP_346487.1 1964912 R 170187 CDS NP_346488.1 15901884 931983 complement(1965536..1966771) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01554; MATE efflux family protein 1966771 931983 SP_2065 Streptococcus pneumoniae TIGR4 MATE efflux family protein NP_346488.1 1965536 R 170187 CDS NP_346489.1 15901885 930302 complement(1966877..1968361) 1 NC_003028.3 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1968361 930302 SP_2066 Streptococcus pneumoniae TIGR4 threonine synthase NP_346489.1 1966877 R 170187 CDS NP_346490.1 15901886 931977 complement(1968437..1969714) 1 NC_003028.3 hypothetical protein 1969714 931977 SP_2067 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346490.1 1968437 R 170187 CDS NP_346491.1 15901887 930267 complement(1976179..1976613) 1 NC_003028.3 cytidine/deoxycytidylate deaminase 1976613 930267 SP_2068 Streptococcus pneumoniae TIGR4 cytidine/deoxycytidylate deaminase NP_346491.1 1976179 R 170187 CDS NP_346492.1 15901888 931970 complement(1976627..1978087) 1 NC_003028.3 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 1978087 gltX 931970 gltX Streptococcus pneumoniae TIGR4 glutamyl-tRNA synthetase NP_346492.1 1976627 R 170187 CDS NP_346493.1 15901889 930266 complement(1978211..1979560) 1 NC_003028.3 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1979560 pgi 930266 pgi Streptococcus pneumoniae TIGR4 glucose-6-phosphate isomerase NP_346493.1 1978211 R 170187 CDS NP_346494.1 15901890 931972 complement(1979547..1979726) 1 NC_003028.3 hypothetical protein 1979726 931972 SP_2071 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346494.1 1979547 R 170187 CDS NP_346495.1 15901891 930265 complement(1979730..1980458) 1 NC_003028.3 glutamine amidotransferase, class-I 1980458 930265 SP_2072 Streptococcus pneumoniae TIGR4 glutamine amidotransferase, class-I NP_346495.1 1979730 R 170187 CDS NP_346496.1 15901892 930264 complement(1980558..1982324) 1 NC_003028.3 ABC transporter ATP-binding protein/permease 1982324 930264 SP_2073 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein/permease NP_346496.1 1980558 R 170187 CDS NP_346497.1 15901893 931969 complement(1983116..1984810) 1 NC_003028.3 ABC transporter ATP-binding protein/permease 1984810 931969 SP_2075 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein/permease NP_346497.1 1983116 R 170187 CDS NP_346498.1 15901894 930261 complement(1987541..1987987) 1 NC_003028.3 transcriptional repressor 1987987 930261 SP_2077 Streptococcus pneumoniae TIGR4 transcriptional repressor NP_346498.1 1987541 R 170187 CDS NP_346499.1 15901895 931968 1988123..1989814 1 NC_003028.3 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1989814 argS 931968 argS Streptococcus pneumoniae TIGR4 arginyl-tRNA synthetase NP_346499.1 1988123 D 170187 CDS NP_346500.1 15901896 930259 complement(1990129..1990518) 1 NC_003028.3 similar to PID:763133; identified by sequence similarity; IS1381 transposase protein B 1990518 930259 SP_2079 Streptococcus pneumoniae TIGR4 IS1381 transposase protein B NP_346500.1 1990129 R 170187 CDS NP_346501.1 15901897 930258 1990696..1991157 1 NC_003028.3 hypothetical protein 1991157 930258 SP_2081 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346501.1 1990696 D 170187 CDS NP_346502.1 15901898 931964 1991241..1991948 1 NC_003028.3 response regulator 1991948 931964 SP_2082 Streptococcus pneumoniae TIGR4 response regulator NP_346502.1 1991241 D 170187 CDS NP_346503.1 15901899 930257 1991949..1993280 1 NC_003028.3 sensor histidine kinase PnpS 1993280 930257 SP_2083 Streptococcus pneumoniae TIGR4 sensor histidine kinase PnpS NP_346503.1 1991949 D 170187 CDS NP_346504.1 15901900 931962 1993447..1994322 1 NC_003028.3 phosphate ABC transporter substrate-binding protein 1994322 931962 SP_2084 Streptococcus pneumoniae TIGR4 phosphate ABC transporter substrate-binding protein NP_346504.1 1993447 D 170187 CDS NP_346505.1 15901901 930255 1994440..1995303 1 NC_003028.3 phosphate ABC transporter permease 1995303 930255 SP_2085 Streptococcus pneumoniae TIGR4 phosphate ABC transporter permease NP_346505.1 1994440 D 170187 CDS NP_346506.1 15901902 931966 1995296..1996111 1 NC_003028.3 phosphate ABC transporter permease 1996111 931966 SP_2086 Streptococcus pneumoniae TIGR4 phosphate ABC transporter permease NP_346506.1 1995296 D 170187 CDS NP_346507.1 15901903 930254 1996113..1996865 1 NC_003028.3 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1996865 930254 SP_2087 Streptococcus pneumoniae TIGR4 phosphate transporter ATP-binding protein NP_346507.1 1996113 D 170187 CDS NP_346508.1 15901904 930253 1996880..1997530 1 NC_003028.3 similar to OMNI:NT01EC4457; identified by sequence similarity; phosphate transport system regulatory protein PhoU 1997530 930253 SP_2088 Streptococcus pneumoniae TIGR4 phosphate transport system regulatory protein PhoU NP_346508.1 1996880 D 170187 CDS NP_346509.1 15901905 931961 complement(1998138..1998578) 1 NC_003028.3 transcriptional regulator 1998578 931961 SP_2090 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_346509.1 1998138 R 170187 CDS NP_346510.1 15901906 930250 1998790..1999806 1 NC_003028.3 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1999806 gpsA 930250 gpsA Streptococcus pneumoniae TIGR4 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase NP_346510.1 1998790 D 170187 CDS NP_346511.1 15901907 931965 1999828..2000727 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR01099; UTP-glucose-1-phosphate uridylyltransferase 2000727 931965 SP_2092 Streptococcus pneumoniae TIGR4 UTP-glucose-1-phosphate uridylyltransferase NP_346511.1 1999828 D 170187 CDS NP_346512.1 15901908 930249 2001118..2002086 1 NC_003028.3 hypothetical protein 2002086 930249 SP_2093 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346512.1 2001118 D 170187 CDS NP_346513.1 15901909 931960 complement(2002387..2003064) 1 NC_003028.3 hypothetical protein 2003064 931960 SP_2094 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346513.1 2002387 R 170187 CDS NP_346514.1 15901910 930248 complement(2003048..2003587) 1 NC_003028.3 5-formyltetrahydrofolate cyclo-ligase 2003587 930248 SP_2095 Streptococcus pneumoniae TIGR4 5-formyltetrahydrofolate cyclo-ligase NP_346514.1 2003048 R 170187 CDS NP_346515.1 15901911 930247 complement(2003599..2004729) 1 NC_003028.3 M20/M25/M40 family peptidase 2004729 930247 SP_2096 Streptococcus pneumoniae TIGR4 M20/M25/M40 family peptidase NP_346515.1 2003599 R 170187 CDS NP_346516.1 15901912 930246 complement(2004797..2005495) 1 NC_003028.3 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 2005495 930246 SP_2097 Streptococcus pneumoniae TIGR4 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase NP_346516.1 2004797 R 170187 CDS NP_346517.1 15901913 930245 complement(2005725..2006636) 1 NC_003028.3 hypothetical protein 2006636 930245 SP_2098 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346517.1 2005725 R 170187 CDS NP_346518.1 15901914 930244 complement(2006701..2009166) 1 NC_003028.3 penicillin-binding protein 1B 2009166 930244 SP_2099 Streptococcus pneumoniae TIGR4 penicillin-binding protein 1B NP_346518.1 2006701 R 170187 CDS NP_346519.1 15901915 931959 2009308..2010564 1 NC_003028.3 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 2010564 931959 SP_2100 Streptococcus pneumoniae TIGR4 tyrosyl-tRNA synthetase NP_346519.1 2009308 D 170187 CDS NP_346520.1 15901916 930243 complement(2010642..2012705) 1 NC_003028.3 cation transporter E1-E2 family ATPase 2012705 930243 SP_2101 Streptococcus pneumoniae TIGR4 cation transporter E1-E2 family ATPase NP_346520.1 2010642 R 170187 CDS NP_346521.1 15901917 931958 complement(2012707..2013018) 1 NC_003028.3 hypothetical protein 2013018 931958 SP_2102 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346521.1 2012707 R 170187 CDS NP_346522.1 15901918 930241 2013137..2013985 1 NC_003028.3 similar to GB:D28496 SP:P36999 PID:460699 GB:U00096 PID:1736466; identified by sequence similarity; rRNA (guanine-N1-)-methyltransferase 2013985 930241 SP_2103 Streptococcus pneumoniae TIGR4 rRNA (guanine-N1-)-methyltransferase NP_346522.1 2013137 D 170187 CDS NP_346523.1 15901919 930240 complement(2014501..2014707) 1 NC_003028.3 hypothetical protein 2014707 930240 SP_2104 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346523.1 2014501 R 170187 CDS NP_346524.1 15901920 931957 2014784..2015356 1 NC_003028.3 hypothetical protein 2015356 931957 SP_2105 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346524.1 2014784 D 170187 CDS NP_346525.1 15901921 930239 complement(2016399..2018657) 1 NC_003028.3 glycogen phosphorylase 2018657 930239 SP_2106 Streptococcus pneumoniae TIGR4 glycogen phosphorylase NP_346525.1 2016399 R 170187 CDS NP_346526.1 15901922 931963 complement(2018683..2020200) 1 NC_003028.3 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 2020200 931963 SP_2107 Streptococcus pneumoniae TIGR4 4-alpha-glucanotransferase NP_346526.1 2018683 R 170187 CDS NP_346527.1 15901923 930238 2020750..2022021 1 NC_003028.3 maltose/maltodextrin ABC transporter maltose/maltodextrin-binding protein 2022021 930238 SP_2108 Streptococcus pneumoniae TIGR4 maltose/maltodextrin ABC transporter maltose/maltodextrin-binding protein NP_346527.1 2020750 D 170187 CDS NP_346528.1 15901924 930237 2022117..2023424 1 NC_003028.3 maltodextrin ABC transporter permease 2023424 930237 SP_2109 Streptococcus pneumoniae TIGR4 maltodextrin ABC transporter permease NP_346528.1 2022117 D 170187 CDS NP_346529.1 15901925 930236 2023426..2024268 1 NC_003028.3 maltodextrin ABC transporter permease 2024268 930236 SP_2110 Streptococcus pneumoniae TIGR4 maltodextrin ABC transporter permease NP_346529.1 2023426 D 170187 CDS NP_346530.1 15901926 931971 2024521..2025321 1 NC_003028.3 similar to GB:L21856 SP:Q08510 PID:347186; identified by sequence similarity; malA protein 2025321 931971 SP_2111 Streptococcus pneumoniae TIGR4 malA protein NP_346530.1 2024521 D 170187 CDS NP_346531.1 15901927 930235 2025331..2026317 1 NC_003028.3 maltose operon transcriptional repressor 2026317 930235 SP_2112 Streptococcus pneumoniae TIGR4 maltose operon transcriptional repressor NP_346531.1 2025331 D 170187 CDS NP_346532.1 15901928 930234 complement(2026609..2027550) 1 NC_003028.3 hypothetical protein 2027550 930234 SP_2113 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346532.1 2026609 R 170187 CDS NP_346533.1 15901929 931956 complement(2027528..2029291) 1 NC_003028.3 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 2029291 aspS 931956 aspS Streptococcus pneumoniae TIGR4 aspartyl-tRNA synthetase NP_346533.1 2027528 R 170187 CDS NP_346534.1 15901930 930233 complement(2029643..2029873) 1 NC_003028.3 hypothetical protein 2029873 930233 SP_2115 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346534.1 2029643 R 170187 CDS NP_346535.1 15901931 931952 complement(2029891..2030532) 1 NC_003028.3 similar to PID:1402529; identified by sequence similarity; hypothetical protein 2030532 931952 SP_2116 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346535.1 2029891 R 170187 CDS NP_346536.1 15901932 930232 complement(2030544..2031224) 1 NC_003028.3 hypothetical protein 2031224 930232 SP_2117 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346536.1 2030544 R 170187 CDS NP_346537.1 15901933 930231 complement(2031280..2031480) 1 NC_003028.3 hypothetical protein 2031480 930231 SP_2118 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346537.1 2031280 R 170187 CDS NP_346538.1 15901934 930229 complement(2031477..2031692) 1 NC_003028.3 transcriptional regulator 2031692 930229 SP_2119 Streptococcus pneumoniae TIGR4 transcriptional regulator NP_346538.1 2031477 R 170187 CDS NP_346539.1 15901935 930228 complement(2031693..2032160) 1 NC_003028.3 hypothetical protein 2032160 930228 SP_2120 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346539.1 2031693 R 170187 CDS NP_346540.1 15901936 931955 complement(2032438..2033727) 1 NC_003028.3 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2033727 hisS 931955 hisS Streptococcus pneumoniae TIGR4 histidyl-tRNA synthetase NP_346540.1 2032438 R 170187 CDS NP_346541.1 15901937 930227 complement(2033805..2035052) 1 NC_003028.3 hypothetical protein 2035052 930227 SP_2122 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346541.1 2033805 R 170187 CDS NP_346542.1 15901938 930225 complement(2036068..2036202) 1 NC_003028.3 hypothetical protein 2036202 930225 SP_2124 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346542.1 2036068 R 170187 CDS NP_346543.1 15901939 931954 2036217..2036558 1 NC_003028.3 hypothetical protein 2036558 931954 SP_2125 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346543.1 2036217 D 170187 CDS NP_346544.1 15901940 930224 complement(2036860..2038563) 1 NC_003028.3 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 2038563 930224 SP_2126 Streptococcus pneumoniae TIGR4 dihydroxy-acid dehydratase NP_346544.1 2036860 R 170187 CDS NP_346545.1 15901941 931951 complement(2038796..2039728) 1 NC_003028.3 similar to GB:AE000512; identified by sequence similarity; transketolase, C-terminal subunit 2039728 931951 SP_2127 Streptococcus pneumoniae TIGR4 transketolase, C-terminal subunit NP_346545.1 2038796 R 170187 CDS NP_346546.1 15901942 930222 complement(2039725..2040582) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00456; transketolase 2040582 930222 SP_2128 Streptococcus pneumoniae TIGR4 transketolase NP_346546.1 2039725 R 170187 CDS NP_346547.1 15901943 931949 complement(2040586..2041932) 1 NC_003028.3 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 2041932 ulaA 931949 ulaA Streptococcus pneumoniae TIGR4 PTS system ascorbate-specific transporter subunit IIC NP_346547.1 2040586 R 170187 CDS NP_346548.1 15901944 930221 complement(2041945..2042229) 1 NC_003028.3 similar to GB:U14003 SP:P39302 PID:537035 GB:U00096 PID:1790638; identified by sequence similarity; PTS system transporter subunit IIB 2042229 930221 SP_2130 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIB NP_346548.1 2041945 R 170187 CDS NP_346549.1 15901945 931948 complement(2042233..2044263) 1 NC_003028.3 BglG family transcriptional regulator 2044263 931948 SP_2131 Streptococcus pneumoniae TIGR4 BglG family transcriptional regulator NP_346549.1 2042233 R 170187 CDS NP_346550.1 15901946 930220 2044455..2045462 1 NC_003028.3 hypothetical protein 2045462 930220 SP_2132 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346550.1 2044455 D 170187 CDS NP_346551.1 15901947 931947 2045465..2045665 1 NC_003028.3 similar to GP:9967664; identified by sequence similarity; hypothetical protein 2045665 931947 SP_2133 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346551.1 2045465 D 170187 CDS NP_346552.1 15901948 930219 2045817..2045999 1 NC_003028.3 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 2045999 rpmF 930219 rpmF Streptococcus pneumoniae TIGR4 50S ribosomal protein L32 NP_346552.1 2045817 D 170187 CDS NP_346553.1 15901949 930218 2046015..2046164 1 NC_003028.3 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 2046164 rpmG 930218 rpmG Streptococcus pneumoniae TIGR4 50S ribosomal protein L33 NP_346553.1 2046015 D 170187 CDS NP_346554.1 15901950 931946 complement(2046656..2048521) 1 NC_003028.3 choline binding protein PcpA 2048521 931946 SP_2136 Streptococcus pneumoniae TIGR4 choline binding protein PcpA NP_346554.1 2046656 R 170187 CDS NP_346555.1 15901951 931945 2049407..2049796 1 NC_003028.3 similar to PID:763133; identified by sequence similarity; IS1381 transposase protein B 2049796 931945 SP_2138 Streptococcus pneumoniae TIGR4 IS1381 transposase protein B NP_346555.1 2049407 D 170187 CDS NP_346556.1 15901952 930216 complement(2049848..2050174) 1 NC_003028.3 hypothetical protein 2050174 930216 SP_2139 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346556.1 2049848 R 170187 CDS NP_346557.1 15901953 931943 complement(2050211..2050420) 1 NC_003028.3 hypothetical protein 2050420 931943 SP_2140 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346557.1 2050211 R 170187 CDS NP_346558.1 15901954 930215 complement(2050572..2052452) 1 NC_003028.3 similar to SP:P43077 PID:432354; identified by sequence similarity; glycosyl hydrolase-like protein 2052452 930215 SP_2141 Streptococcus pneumoniae TIGR4 glycosyl hydrolase-like protein NP_346558.1 2050572 R 170187 CDS NP_346559.1 15901955 931944 complement(2052446..2053315) 1 NC_003028.3 ROK family protein 2053315 931944 SP_2142 Streptococcus pneumoniae TIGR4 ROK family protein NP_346559.1 2052446 R 170187 CDS NP_346560.1 15901956 930214 complement(2053398..2056058) 1 NC_003028.3 hypothetical protein 2056058 930214 SP_2143 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346560.1 2053398 R 170187 CDS NP_346561.1 15901957 931941 complement(2056134..2057414) 1 NC_003028.3 hypothetical protein 2057414 931941 SP_2144 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346561.1 2056134 R 170187 CDS NP_346562.1 15901958 930213 2057586..2059670 1 NC_003028.3 cell wall antigen 2059670 930213 SP_2145 Streptococcus pneumoniae TIGR4 cell wall antigen NP_346562.1 2057586 D 170187 CDS NP_346563.1 15901959 931940 complement(2059710..2061389) 1 NC_003028.3 hypothetical protein 2061389 931940 SP_2146 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346563.1 2059710 R 170187 CDS NP_346564.1 15901960 930212 2061782..2062006 1 NC_003028.3 hypothetical protein 2062006 930212 SP_2147 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346564.1 2061782 D 170187 CDS NP_346565.1 15901961 931942 2062144..2063373 1 NC_003028.3 catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 2063373 931942 SP_2148 Streptococcus pneumoniae TIGR4 arginine deiminase NP_346565.1 2062144 D 170187 CDS NP_346566.1 15901962 930211 2063431..2064447 1 NC_003028.3 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 2064447 930211 SP_2150 Streptococcus pneumoniae TIGR4 ornithine carbamoyltransferase NP_346566.1 2063431 D 170187 CDS NP_346567.1 15901963 930210 2064612..2065559 1 NC_003028.3 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 2065559 930210 SP_2151 Streptococcus pneumoniae TIGR4 carbamate kinase NP_346567.1 2064612 D 170187 CDS NP_346568.1 15901964 930207 2065768..2067279 1 NC_003028.3 hypothetical protein 2067279 930207 SP_2152 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346568.1 2065768 D 170187 CDS NP_346569.1 15901965 931937 2067301..2068632 1 NC_003028.3 hypothetical protein 2068632 931937 SP_2153 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346569.1 2067301 D 170187 CDS NP_346570.1 15901966 930205 complement(2069966..2070790) 1 NC_003028.3 hypothetical protein 2070790 930205 SP_2156 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346570.1 2069966 R 170187 CDS NP_346571.1 15901967 931936 complement(2070995..2072146) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00465; iron-containing alcohol dehydrogenase 2072146 931936 SP_2157 Streptococcus pneumoniae TIGR4 iron-containing alcohol dehydrogenase NP_346571.1 2070995 R 170187 CDS NP_346572.1 15901968 930204 complement(2072292..2074058) 1 NC_003028.3 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 2074058 fucI 930204 fucI Streptococcus pneumoniae TIGR4 L-fucose isomerase NP_346572.1 2072292 R 170187 CDS NP_346573.1 15901969 931935 complement(2074141..2077257) 1 NC_003028.3 similar to GP:9651025; identified by sequence similarity; fucolectin-like protein 2077257 931935 SP_2159 Streptococcus pneumoniae TIGR4 fucolectin-like protein NP_346573.1 2074141 R 170187 CDS NP_346574.1 15901970 930203 complement(2077267..2079561) 1 NC_003028.3 hypothetical protein 2079561 930203 SP_2160 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346574.1 2077267 R 170187 CDS NP_346575.1 15901971 931934 complement(2079620..2080420) 1 NC_003028.3 PTS system transporter subunit IID 2080420 931934 SP_2161 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IID NP_346575.1 2079620 R 170187 CDS NP_346576.1 15901972 930202 complement(2080417..2081190) 1 NC_003028.3 PTS system transporter subunit IIC 2081190 930202 SP_2162 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIC NP_346576.1 2080417 R 170187 CDS NP_346577.1 15901973 931933 complement(2081215..2081685) 1 NC_003028.3 PTS system transporter subunit IIB 2081685 931933 SP_2163 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIB NP_346577.1 2081215 R 170187 CDS NP_346578.1 15901974 930201 complement(2081676..2082107) 1 NC_003028.3 PTS system transporter subunit IIA 2082107 930201 SP_2164 Streptococcus pneumoniae TIGR4 PTS system transporter subunit IIA NP_346578.1 2081676 R 170187 CDS NP_346579.1 15901975 931939 complement(2082097..2082540) 1 NC_003028.3 similar to GB:L42023 SP:P44778 PID:1005441 PID:1220689 PID:1204863; identified by sequence similarity; fucose operon FucU protein 2082540 931939 SP_2165 Streptococcus pneumoniae TIGR4 fucose operon FucU protein NP_346579.1 2082097 R 170187 CDS NP_346580.1 15901976 930200 complement(2082552..2083190) 1 NC_003028.3 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 2083190 930200 SP_2166 Streptococcus pneumoniae TIGR4 L-fuculose phosphate aldolase NP_346580.1 2082552 R 170187 CDS NP_346581.1 15901977 931931 complement(2083305..2084708) 1 NC_003028.3 L-fuculose kinase fucK 2084708 931931 SP_2167 Streptococcus pneumoniae TIGR4 L-fuculose kinase fucK NP_346581.1 2083305 R 170187 CDS NP_346582.1 15901978 930197 2084884..2085657 1 NC_003028.3 fucose operon repressor 2085657 930197 SP_2168 Streptococcus pneumoniae TIGR4 fucose operon repressor NP_346582.1 2084884 D 170187 CDS NP_346583.1 15901979 931930 complement(2086817..2088322) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01297; zinc ABC transporter zinc-binding lipoprotein 2088322 931930 SP_2169 Streptococcus pneumoniae TIGR4 zinc ABC transporter zinc-binding lipoprotein NP_346583.1 2086817 R 170187 CDS NP_346584.1 15901980 930196 complement(2088332..2089138) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00950; zinc ABC transporter permease 2089138 930196 SP_2170 Streptococcus pneumoniae TIGR4 zinc ABC transporter permease NP_346584.1 2088332 R 170187 CDS NP_346585.1 15901981 930195 complement(2089131..2089835) 1 NC_003028.3 zinc ABC transporter ATP-binding protein 2089835 930195 SP_2171 Streptococcus pneumoniae TIGR4 zinc ABC transporter ATP-binding protein NP_346585.1 2089131 R 170187 CDS NP_346586.1 15901982 931929 complement(2089835..2090275) 1 NC_003028.3 adc operon repressor AdcR 2090275 931929 SP_2172 Streptococcus pneumoniae TIGR4 adc operon repressor AdcR NP_346586.1 2089835 R 170187 CDS NP_346587.1 15901983 930194 complement(2090430..2091680) 1 NC_003028.3 similar to GP:6456613; identified by sequence similarity; dltD protein 2091680 930194 SP_2173 Streptococcus pneumoniae TIGR4 dltD protein NP_346587.1 2090430 R 170187 CDS NP_346588.1 15901984 930193 complement(2091691..2091930) 1 NC_003028.3 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 2091930 930193 SP_2174 Streptococcus pneumoniae TIGR4 D-alanine--poly(phosphoribitol) ligase subunit 2 NP_346588.1 2091691 R 170187 CDS NP_346589.1 15901985 930192 complement(2091944..2093185) 1 NC_003028.3 similar to GP:2952530; identified by sequence similarity; dltB protein 2093185 930192 SP_2175 Streptococcus pneumoniae TIGR4 dltB protein NP_346589.1 2091944 R 170187 CDS NP_346590.1 15901986 931927 complement(2093185..2094735) 1 NC_003028.3 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 2094735 931927 SP_2176 Streptococcus pneumoniae TIGR4 D-alanine--poly(phosphoribitol) ligase subunit 1 NP_346590.1 2093185 R 170187 CDS NP_346591.1 15901987 930191 complement(2094756..2094890) 1 NC_003028.3 hypothetical protein 2094890 930191 SP_2177 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346591.1 2094756 R 170187 CDS NP_346592.1 15901988 930190 complement(2095739..2097085) 1 NC_003028.3 similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 2097085 930190 SP_2179 Streptococcus pneumoniae TIGR4 IS1380-Spn1 transposase NP_346592.1 2095739 R 170187 CDS NP_346593.1 15901989 931928 2100871..2101458 1 NC_003028.3 hypothetical protein 2101458 931928 SP_2182 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346593.1 2100871 D 170187 CDS NP_346594.1 15901990 930188 complement(2101545..2101748) 1 NC_003028.3 hypothetical protein 2101748 930188 SP_2183 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346594.1 2101545 R 170187 CDS NP_346595.1 15901991 931924 complement(2102045..2102749) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00230; glycerol uptake facilitator protein 2102749 931924 SP_2184 Streptococcus pneumoniae TIGR4 glycerol uptake facilitator protein NP_346595.1 2102045 R 170187 CDS NP_346596.1 15901992 930187 complement(2102819..2104645) 1 NC_003028.3 hypothetical protein 2104645 930187 SP_2185 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346596.1 2102819 R 170187 CDS NP_346597.1 15901993 931923 complement(2104687..2106195) 1 NC_003028.3 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 2106195 glpK 931923 glpK Streptococcus pneumoniae TIGR4 glycerol kinase NP_346597.1 2104687 R 170187 CDS NP_346598.1 15901994 930185 complement(2106354..2107781) 1 NC_003028.3 similar to GP:409925; identified by sequence similarity; hypothetical protein 2107781 930185 SP_2187 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346598.1 2106354 R 170187 CDS NP_346599.1 15901995 931922 2107946..2108818 1 NC_003028.3 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; heat shock protein 33 2108818 hslO 931922 hslO Streptococcus pneumoniae TIGR4 heat shock protein 33 NP_346599.1 2107946 D 170187 CDS NP_346600.1 15901996 930184 2108829..2109785 1 NC_003028.3 identified by match to PFAM protein family HMM PF01207; NifR3 family TIM-barrel protein 2109785 930184 SP_2189 Streptococcus pneumoniae TIGR4 NifR3 family TIM-barrel protein NP_346600.1 2108829 D 170187 CDS NP_346601.1 15901997 931921 complement(2110015..2112096) 1 NC_003028.3 choline binding protein A 2112096 931921 SP_2190 Streptococcus pneumoniae TIGR4 choline binding protein A NP_346601.1 2110015 R 170187 CDS NP_346602.1 15901998 930183 complement(2112175..2112702) 1 NC_003028.3 hypothetical protein 2112702 930183 SP_2191 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346602.1 2112175 R 170187 CDS NP_346603.1 15901999 931920 complement(2112785..2114116) 1 NC_003028.3 sensor histidine kinase 2114116 931920 SP_2192 Streptococcus pneumoniae TIGR4 sensor histidine kinase NP_346603.1 2112785 R 170187 CDS NP_346604.1 15902000 930182 complement(2114113..2114766) 1 NC_003028.3 DNA-binding response regulator 2114766 930182 SP_2193 Streptococcus pneumoniae TIGR4 DNA-binding response regulator NP_346604.1 2114113 R 170187 CDS NP_346605.1 15902001 931938 complement(2115408..2117840) 1 NC_003028.3 ATP-dependent Clp protease ATP-binding subunit 2117840 931938 SP_2194 Streptococcus pneumoniae TIGR4 ATP-dependent Clp protease ATP-binding subunit NP_346605.1 2115408 R 170187 CDS NP_346606.1 15902002 930181 complement(2117842..2118300) 1 NC_003028.3 similar to GB:D26185 SP:P37568 PID:467471 GB:AL009126; identified by sequence similarity; CtsR family transcriptional regulator 2118300 930181 SP_2195 Streptococcus pneumoniae TIGR4 CtsR family transcriptional regulator NP_346606.1 2117842 R 170187 CDS NP_346607.1 15902003 930180 complement(2118419..2119147) 1 NC_003028.3 ABC transporter ATP-binding protein 2119147 930180 SP_2196 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_346607.1 2118419 R 170187 CDS NP_346608.1 15902004 930179 complement(2119147..2120154) 1 NC_003028.3 similar to GB:AE001363; identified by sequence similarity; ABC transporter substrate-binding protein 2120154 930179 SP_2197 Streptococcus pneumoniae TIGR4 ABC transporter substrate-binding protein NP_346608.1 2119147 R 170187 CDS NP_346609.1 15902005 931918 complement(2120193..2120942) 1 NC_003028.3 ABC transporter permease 2120942 931918 SP_2198 Streptococcus pneumoniae TIGR4 ABC transporter permease NP_346609.1 2120193 R 170187 CDS NP_346610.1 15902006 930493 complement(2120914..2121204) 1 NC_003028.3 hypothetical protein 2121204 930493 SP_2199 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346610.1 2120914 R 170187 CDS NP_346611.1 15902007 930058 2121383..2121493 1 NC_003028.3 hypothetical protein 2121493 930058 SP_2200 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346611.1 2121383 D 170187 CDS NP_346612.1 15902008 931907 complement(2121460..2122806) 1 NC_003028.3 choline binding protein D 2122806 931907 SP_2201 Streptococcus pneumoniae TIGR4 choline binding protein D NP_346612.1 2121460 R 170187 CDS NP_346613.1 15902009 930008 complement(2122895..2123161) 1 NC_003028.3 hypothetical protein 2123161 930008 SP_2202 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346613.1 2122895 R 170187 CDS NP_346614.1 15902010 931904 complement(2123163..2124515) 1 NC_003028.3 unwinds double stranded DNA; replicative DNA helicase 2124515 931904 SP_2203 Streptococcus pneumoniae TIGR4 replicative DNA helicase NP_346614.1 2123163 R 170187 CDS NP_346615.1 15902011 929818 complement(2124559..2125011) 1 NC_003028.3 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 2125011 rplI 929818 rplI Streptococcus pneumoniae TIGR4 50S ribosomal protein L9 NP_346615.1 2124559 R 170187 CDS NP_346616.1 15902012 929903 complement(2125008..2126981) 1 NC_003028.3 identified by match to PFAM protein family HMM PF02272; DHH subfamily 1 protein 2126981 929903 SP_2205 Streptococcus pneumoniae TIGR4 DHH subfamily 1 protein NP_346616.1 2125008 R 170187 CDS NP_346617.1 15902013 931897 complement(2127117..2127665) 1 NC_003028.3 ribosomal subunit interface protein 2127665 931897 SP_2206 Streptococcus pneumoniae TIGR4 ribosomal subunit interface protein NP_346617.1 2127117 R 170187 CDS NP_346618.1 15902014 929909 complement(2127745..2128407) 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR00201; competence protein ComF 2128407 929909 SP_2207 Streptococcus pneumoniae TIGR4 competence protein ComF NP_346618.1 2127745 R 170187 CDS NP_346619.1 15902015 931893 complement(2128404..2129702) 1 NC_003028.3 helicase 2129702 931893 SP_2208 Streptococcus pneumoniae TIGR4 helicase NP_346619.1 2128404 R 170187 CDS NP_346620.1 15902016 929929 2129758..2130393 1 NC_003028.3 hypothetical protein 2130393 929929 SP_2209 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346620.1 2129758 D 170187 CDS NP_346621.1 15902017 929865 2130642..2131562 1 NC_003028.3 identified by match to TIGR protein family HMM TIGR01139; cysteine synthase 2131562 929865 SP_2210 Streptococcus pneumoniae TIGR4 cysteine synthase NP_346621.1 2130642 D 170187 CDS NP_346622.1 15902018 931906 complement(2133145..2134185) 1 NC_003028.3 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 2134185 tsf 931906 tsf Streptococcus pneumoniae TIGR4 elongation factor Ts NP_346622.1 2133145 R 170187 CDS NP_346623.1 15902019 929982 complement(2134264..2135043) 1 NC_003028.3 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 2135043 rpsB 929982 rpsB Streptococcus pneumoniae TIGR4 30S ribosomal protein S2 NP_346623.1 2134264 R 170187 CDS NP_346624.1 15902020 929879 complement(2135267..2136445) 1 NC_003028.3 similar to GB:M60178 SP:P22865 PID:149525 PID:512521; identified by sequence similarity; hypothetical protein 2136445 929879 SP_2216 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346624.1 2135267 R 170187 CDS NP_346625.1 15902021 929895 complement(2136539..2137033) 1 NC_003028.3 similar to GP:9246949; identified by sequence similarity; rod shpae-determining protein MreD 2137033 929895 SP_2217 Streptococcus pneumoniae TIGR4 rod shpae-determining protein MreD NP_346625.1 2136539 R 170187 CDS NP_346626.1 15902022 929881 complement(2137033..2137851) 1 NC_003028.3 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 2137851 929881 SP_2218 Streptococcus pneumoniae TIGR4 rod shape-determining protein MreC NP_346626.1 2137033 R 170187 CDS NP_346627.1 15902023 931890 complement(2137910..2138704) 1 NC_003028.3 hypothetical protein 2138704 931890 SP_2219 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346627.1 2137910 R 170187 CDS NP_346628.1 15902024 929887 complement(2138697..2139536) 1 NC_003028.3 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 2139536 cbiO 929887 cbiO Streptococcus pneumoniae TIGR4 cobalt transporter ATP-binding subunit NP_346628.1 2138697 R 170187 CDS NP_346629.1 15902025 931891 complement(2139521..2140348) 1 NC_003028.3 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 2140348 cbiO 931891 cbiO Streptococcus pneumoniae TIGR4 cobalt transporter ATP-binding subunit NP_346629.1 2139521 R 170187 CDS NP_346630.1 15902026 929871 complement(2140345..2140890) 1 NC_003028.3 identified by match to PFAM protein family HMM PF01066; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 2140890 929871 SP_2222 Streptococcus pneumoniae TIGR4 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase NP_346630.1 2140345 R 170187 CDS NP_346631.1 15902027 931889 complement(2140901..2141731) 1 NC_003028.3 hypothetical protein 2141731 931889 SP_2223 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346631.1 2140901 R 170187 CDS NP_346632.1 15902028 929843 complement(2141764..2143047) 1 NC_003028.3 identified by match to PFAM protein family HMM PF00675; M16 family peptidase 2143047 929843 SP_2224 Streptococcus pneumoniae TIGR4 M16 family peptidase NP_346632.1 2141764 R 170187 CDS NP_346633.1 15902029 929864 complement(2143044..2144294) 1 NC_003028.3 hypothetical protein 2144294 929864 SP_2225 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346633.1 2143044 R 170187 CDS NP_346634.1 15902030 931888 2144453..2144821 1 NC_003028.3 hypothetical protein 2144821 931888 SP_2226 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346634.1 2144453 D 170187 CDS NP_346635.1 15902031 929856 2144824..2145921 1 NC_003028.3 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2145921 recF 929856 recF Streptococcus pneumoniae TIGR4 recombination protein F NP_346635.1 2144824 D 170187 CDS NP_346636.1 15902032 931886 complement(2145972..2147450) 1 NC_003028.3 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2147450 931886 SP_2228 Streptococcus pneumoniae TIGR4 inosine 5'-monophosphate dehydrogenase NP_346636.1 2145972 R 170187 CDS NP_346637.1 15902033 930554 complement(2147602..2148627) 1 NC_003028.3 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 2148627 930554 SP_2229 Streptococcus pneumoniae TIGR4 tryptophanyl-tRNA synthetase NP_346637.1 2147602 R 170187 CDS NP_346638.1 15902034 929840 2148833..2150455 1 NC_003028.3 ABC transporter ATP-binding protein 2150455 929840 SP_2230 Streptococcus pneumoniae TIGR4 ABC transporter ATP-binding protein NP_346638.1 2148833 D 170187 CDS NP_346639.1 15902035 929826 2150517..2153069 1 NC_003028.3 ABC transporter permease 2153069 929826 SP_2231 Streptococcus pneumoniae TIGR4 ABC transporter permease NP_346639.1 2150517 D 170187 CDS NP_346640.1 15902036 929837 complement(2153934..2154701) 1 NC_003028.3 hypothetical protein 2154701 929837 SP_2233 Streptococcus pneumoniae TIGR4 hypothetical protein NP_346640.1 2153934 R 170187 CDS NP_346641.1 15902037 931884 2154880..2155422 1 NC_003028.3 TetR family transcriptional regulator 2155422 931884 SP_2234 Streptococcus pneumoniae TIGR4 TetR family transcriptional regulator NP_346641.1 2154880 D 170187 CDS NP_346642.1 15902038 930062 complement(2155665..2156417) 1 NC_003028.3 response regulator ComE 2156417 930062 SP_2235 Streptococcus pneumoniae TIGR4 response regulator ComE NP_346642.1 2155665 R 170187 CDS NP_346643.1 15902039 931908 complement(2156414..2157739) 1 NC_003028.3 sensor histidine kinase ComD 2157739 931908 SP_2236 Streptococcus pneumoniae TIGR4 sensor histidine kinase ComD NP_346643.1 2156414 R 170187 CDS NP_346644.1 15902040 929807 complement(2157760..2157885) 1 NC_003028.3 similar to SP:P72507; identified by sequence similarity; competence stimulating peptide 2 2157885 929807 SP_2237 Streptococcus pneumoniae TIGR4 competence stimulating peptide 2 NP_346644.1 2157760 R 170187 CDS NP_346645.1 15902041 931872 complement(2158167..2158646) 1 NC_003028.3 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 2158646 931872 SP_2238 Streptococcus pneumoniae TIGR4 rRNA large subunit methyltransferase NP_346645.1 2158167 R 170187 CDS NP_346646.1 15902042 929800 2158829..2160010 1 NC_003028.3 serine protease 2160010 929800 SP_2239 Streptococcus pneumoniae TIGR4 serine protease NP_346646.1 2158829 D 170187 CDS NP_346647.1 15902043 931874 2160068..2160826 1 NC_003028.3 identified by match to PFAM protein family HMM PF02195; spspoJ protein 2160826 931874 SP_2240 Streptococcus pneumoniae TIGR4 spspoJ protein NP_346647.1 2160068 D 170187 CDS