-- dump date 20140620_085419 -- class Genbank::CDS -- table cds_note -- id note NP_344554.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. NP_344555.1 binds the polymerase to DNA and acts as a sliding clamp NP_344557.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 NP_344558.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation NP_344559.1 identified by match to TIGR protein family HMM TIGR00580 NP_344563.1 similar to PID:683698; identified by sequence similarity NP_344565.1 Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively NP_344566.1 identified by match to PFAM protein family HMM PF01434 NP_344567.1 similar to GP:5739312; identified by sequence similarity NP_344571.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis NP_344573.1 catalyzes the formation of dUMP from dUTP NP_344578.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP NP_344580.1 similar to GP:1469653; identified by sequence similarity NP_344582.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair NP_344585.1 catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci NP_344586.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA NP_344587.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY NP_344588.1 identified by match to PFAM protein family HMM PF00550 NP_344590.1 similar to GP:9798576; identified by sequence similarity NP_344593.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase NP_344594.1 identified by match to PFAM protein family HMM PF00586 NP_344595.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway NP_344596.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis NP_344597.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate NP_344598.1 similar to GP:6448500; identified by sequence similarity NP_344599.1 involved in de novo purine biosynthesis NP_344600.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis NP_344602.1 Catalyzes a step in the de novo purine nucleotide biosynthetic pathway NP_344603.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway NP_344605.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide NP_344606.1 identified by match to PFAM protein family HMM PF00746 NP_344609.1 identified by match to PFAM protein family HMM PF01301 NP_344615.1 identified by match to PFAM protein family HMM PF01263 NP_344624.1 identified by match to PFAM protein family HMM PF01048 NP_344628.1 identified by match to PFAM protein family HMM PF02254 NP_344630.1 identified by match to PFAM protein family HMM PF00746 NP_344633.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination NP_344644.1 similar to GP:8953759; identified by sequence similarity NP_344651.1 identified by match to PFAM protein family HMM PF00702 NP_344652.1 identified by match to TIGR protein family HMM TIGR00718 NP_344653.1 identified by match to TIGR protein family HMM TIGR00719 NP_344656.1 similar to GP:3355782; identified by sequence similarity NP_344664.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs NP_344666.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs NP_344667.1 identified by match to PFAM protein family HMM PF02147 NP_344669.1 similar to SP:P39554 PID:456140; identified by sequence similarity NP_344675.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity NP_344682.1 similar to GP:4689219; identified by sequence similarity NP_344685.1 similar to GB:AL009126; identified by sequence similarity NP_344700.1 has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF NP_344702.1 similar to GP:6690328; identified by sequence similarity NP_344703.1 similar to PID:1196936; identified by sequence similarity NP_344707.1 similar to SP:P30197 GB:X62386 PID:46970; identified by sequence similarity NP_344714.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex NP_344716.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not NP_344717.1 identified by match to PFAM protein family HMM PF00926 NP_344718.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine NP_344719.1 identified by match to TIGR protein family HMM TIGR00326 NP_344720.1 plays an essential role in ATP-dependent branch migration of the Holliday junction NP_344723.1 identified by match to PFAM protein family HMM PF02016 NP_344726.1 identified by match to PFAM protein family HMM PF01544 NP_344727.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate NP_344728.1 identified by match to PFAM protein family HMM PF00557 NP_344730.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress NP_344740.1 similar to GB:Pyro_h; identified by sequence similarity NP_344742.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates NP_344745.1 identified by match to PFAM protein family HMM PF02143 NP_344747.1 similar to GP:7302796; identified by sequence similarity NP_344748.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex NP_344749.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin NP_344750.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA NP_344751.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel NP_344752.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation NP_344753.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA NP_344754.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center NP_344755.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation NP_344756.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e NP_344757.1 one of the stabilizing components for the large ribosomal subunit NP_344758.1 primary binding protein; helps mediate assembly; involved in translation fidelity NP_344759.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase NP_344760.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel NP_344761.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 NP_344762.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif NP_344764.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit NP_344765.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance NP_344766.1 binds 5S rRNA along with protein L5 and L25 NP_344767.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance NP_344768.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 NP_344769.1 late assembly protein NP_344770.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_344771.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP NP_344772.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 NP_344773.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif NP_344774.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA NP_344775.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 NP_344776.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme NP_344777.1 is a component of the macrolide binding site in the peptidyl transferase center NP_344778.1 ACT domain-containing protein NP_344784.1 identified by match to PFAM protein family HMM PF02143 NP_344786.1 similar to SP:P37078 GB:X66059 PID:43938; identified by sequence similarity NP_344790.1 identified by match to PFAM protein family HMM PF01228 NP_344791.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies NP_344792.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone NP_344793.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase NP_344797.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration NP_344799.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate NP_344801.1 identified by match to TIGR protein family HMM TIGR00054 NP_344802.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) NP_344804.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source NP_344805.1 similar to GP:2735505; identified by sequence similarity NP_344806.1 identified by match to PFAM protein family HMM PF00746 NP_344809.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance NP_344810.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit NP_344811.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene NP_344812.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity NP_344816.1 identified by match to PFAM protein family HMM PF02073 NP_344819.1 similar to GB:Z30315 PID:535273; identified by sequence similarity NP_344823.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs NP_344827.1 identified by match to PFAM protein family HMM PF00809 NP_344829.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer NP_344830.1 identified by match to PFAM protein family HMM PF01288 NP_344832.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit NP_344833.1 forms a direct contact with the tRNA during translation NP_344839.1 similar to GP:9658050; identified by sequence similarity NP_344840.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism NP_344842.1 required for cellobiose uptake and metabolism NP_344845.1 required for cellobiose uptake and metabolism NP_344847.1 required for cellobiose uptake and metabolism NP_344849.1 identified by match to PFAM protein family HMM PF01055 NP_344850.1 identified by match to PFAM protein family HMM PF00255 NP_344851.1 identified by match to PFAM protein family HMM PF02278 NP_344853.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate NP_344856.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate NP_344858.1 similar to GP:5869507; identified by sequence similarity NP_344862.1 identified by match to TIGR protein family HMM TIGR00739 NP_344864.1 similar to GP:8163721; identified by sequence similarity NP_344870.1 similar to GP:1524351; identified by sequence similarity NP_344872.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan NP_344874.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 NP_344877.1 similar to GP:8163721; identified by sequence similarity YP_873925.1 Orf1 NP_344880.1 similar to GP:3550628; identified by sequence similarity NP_344883.1 identified by match to PFAM protein family HMM PF02397 NP_344885.1 similar to GP:1657647; identified by sequence similarity NP_344890.1 identified by match to PFAM protein family HMM PF02350 NP_344893.1 identified by match to TIGR protein family HMM TIGR00236 NP_344897.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC NP_344902.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate NP_344909.1 identified by match to TIGR protein family HMM TIGR01240 NP_344910.1 identified by match to TIGR protein family HMM TIGR01220 NP_344911.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate NP_344921.1 identified by match to PFAM protein family HMM PF01232 NP_344923.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer NP_344924.1 identified by match to PFAM protein family HMM PF01443 NP_344926.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids NP_344931.1 identified by match to PFAM protein family HMM PF01235 NP_344934.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_344936.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive NP_344938.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA NP_344940.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs NP_344941.1 carries the fatty acid chain in fatty acid biosynthesis NP_344943.1 identified by match to TIGR protein family HMM TIGR00128 NP_344944.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis NP_344945.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP NP_344946.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism NP_344947.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP NP_344948.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism NP_344949.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits NP_344950.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus NP_344954.1 similar to GB:AL009126; identified by sequence similarity NP_344955.1 Regulates rRNA biosynthesis by transcriptional antitermination NP_344957.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA NP_344958.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_344959.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA NP_344960.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain NP_344961.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein NP_344962.1 required for 70S ribosome assembly NP_344966.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit NP_344967.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit NP_344968.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis NP_344971.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic NP_344977.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell NP_344978.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function NP_344979.1 identified by match to PFAM protein family HMM PF01228 NP_344981.1 similar to GP:1289510; identified by sequence similarity NP_344983.1 identified by match to PFAM protein family HMM PF00746 NP_344984.1 similar to PID:666069; identified by sequence similarity NP_344986.1 similar to GP:3036999; identified by sequence similarity NP_344987.1 similar to GP:3036999; identified by sequence similarity NP_344988.1 similar to GP:3036999; identified by sequence similarity NP_344993.1 identified by match to PFAM protein family HMM PF02378 NP_344996.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside NP_344999.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain NP_345007.1 identified by match to PFAM protein family HMM PF01569 NP_345011.3 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling NP_345012.1 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer NP_345013.1 similar to GP:8163721; identified by sequence similarity NP_345016.1 identified by match to PFAM protein family HMM PF00746 NP_345017.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway NP_345018.1 similar to GB:AL009126; identified by sequence similarity NP_345020.1 identified by match to TIGR protein family HMM TIGR00653 NP_345033.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons NP_345034.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor NP_345035.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria NP_345037.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion NP_345039.1 identified by match to PFAM protein family HMM PF01230 NP_345041.1 similar to PID:1177254 SP:P55340 PID:2226114 GB:AL009126; identified by sequence similarity NP_345042.1 similar to GP:9798558; identified by sequence similarity NP_345043.1 similar to GP:9798559; identified by sequence similarity NP_345045.1 similar to GP:5830551; identified by sequence similarity NP_345046.1 similar to GP:9798562; identified by sequence similarity NP_345048.1 similar to GP:9798565; identified by sequence similarity NP_345049.1 similar to GP:9798566; identified by sequence similarity NP_345050.1 similar to GP:9798567; identified by sequence similarity NP_345053.1 similar to GP:9798568; identified by sequence similarity NP_345054.1 similar to PID:763133; identified by sequence similarity NP_345055.1 similar to PID:763133; identified by sequence similarity NP_345056.1 similar to GP:9798569; identified by sequence similarity NP_345057.1 similar to GP:9798570; identified by sequence similarity NP_345058.1 similar to GP:9798571; identified by sequence similarity NP_345061.1 similar to GP:9798572; identified by sequence similarity NP_345062.1 similar to PID:1495680; identified by sequence similarity NP_345063.1 similar to GP:9798574; identified by sequence similarity NP_345064.1 similar to GB:AL009126; identified by sequence similarity NP_345067.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine NP_345068.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins NP_345069.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination NP_345071.1 identified by match to PFAM protein family HMM PF01248 NP_345072.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex NP_345073.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock NP_345077.1 similar to GB:AE000782; identified by sequence similarity NP_345081.1 similar to GP:8927331; identified by sequence similarity NP_345084.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain NP_345085.1 similar to GP:2687741; identified by sequence similarity NP_345090.1 identified by match to PFAM protein family HMM PF00874 NP_345093.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily NP_345095.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily NP_345098.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine NP_345099.1 identified by match to PFAM protein family HMM PF02219 NP_345101.1 identified by match to PFAM protein family HMM PF01138 NP_345102.1 identified by match to TIGR protein family HMM TIGR01172 NP_345104.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA NP_345111.1 similar to GP:5712667; identified by sequence similarity NP_345113.1 similar to GP:5712669; identified by sequence similarity NP_345117.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate NP_345123.2 identified by match to PFAM protein family HMM PF02272 NP_345125.1 identified by match to PFAM protein family HMM PF02147 NP_345127.1 similar to GP:7649681; identified by sequence similarity NP_345128.1 similar to GP:7649683; identified by sequence similarity NP_345130.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision NP_345134.1 identified by match to PFAM protein family HMM PF00881 NP_345135.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases NP_345137.1 identified by match to TIGR protein family HMM TIGR00796 NP_345139.1 similar to SP:Q04344 PID:1431187 PID:3499; identified by sequence similarity NP_345141.1 binds directly to 23S ribosomal RNA NP_345142.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA NP_345144.1 similar to GP:7160903; identified by sequence similarity NP_345147.1 similar to GP:7636000; identified by sequence similarity NP_345151.1 identified by match to PFAM protein family HMM PF00746 NP_345153.1 similar to SP:P37188 GB:X79837 PID:508174 GB:U00096 PID:1736810; identified by sequence similarity NP_345155.1 identified by match to PFAM protein family HMM PF00703 NP_345160.2 identified by match to PFAM protein family HMM PF00999 NP_345163.1 similar to GP:6714962; identified by sequence similarity NP_345165.1 this fusion consists of methionine sulfoxide A reductase at the N-terminus and B at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion NP_345169.1 identified by match to PFAM protein family HMM PF00746 NP_345170.1 identified by match to PFAM protein family HMM PF00425 NP_345174.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived NP_345176.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity NP_345179.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions NP_345193.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation NP_345194.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis NP_345195.1 similar to GP:4009482; identified by sequence similarity NP_345200.1 identified by match to PFAM protein family HMM PF00899 NP_345204.1 OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase NP_345205.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate NP_345214.3 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 NP_345215.1 similar to GP:8163721; identified by sequence similarity NP_345216.1 identified by match to PFAM protein family HMM PF01070 NP_345217.1 similar to GB:X59720 SP:P25362 PID:1907163; identified by sequence similarity NP_345218.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP NP_345223.1 similar to GB:M73546 SP:P25052 PID:143729 GB:AL009126; identified by sequence similarity NP_345224.1 similar to GB:NC_000854; identified by sequence similarity NP_345226.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate NP_345227.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine NP_345232.1 similar to GP:7981392; identified by sequence similarity NP_345235.1 identified by match to PFAM protein family HMM PF01238 NP_345244.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate NP_345245.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_873927.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 NP_345260.1 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase NP_345262.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group NP_345263.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA NP_345266.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance NP_345267.1 similar to GP:7110140; identified by sequence similarity NP_345273.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity NP_345276.1 Essential for efficient processing of 16S rRNA NP_345277.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA NP_345281.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense NP_345285.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content NP_345290.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis NP_345294.1 identified by match to PFAM protein family HMM PF01433 NP_345299.1 unwinds DNA NP_345302.1 identified by match to PFAM protein family HMM PF00702 NP_345303.1 negatively supercoils closed circular double-stranded DNA NP_345304.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation YP_873929.1 Orf1 NP_345312.1 identified by match to PFAM protein family HMM PF02151 NP_345317.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate NP_345319.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway NP_345320.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose NP_345322.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation NP_345325.1 similar to GP:3309561; identified by sequence similarity NP_345326.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate NP_345329.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase NP_345330.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis NP_345333.1 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway NP_345334.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate NP_345335.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis NP_345339.1 similar to GB:AL009126; identified by sequence similarity NP_345340.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX NP_345341.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_345344.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling NP_345345.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids NP_345346.1 similar to GP:6968020; identified by sequence similarity NP_345348.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline NP_345350.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins NP_345352.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA NP_345358.1 identified by match to PFAM protein family HMM PF01458 NP_345359.1 identified by match to PFAM protein family HMM PF00768 NP_345365.1 identified by match to PFAM protein family HMM PF01580 NP_345368.1 Required for the synthesis of the thiazole moiety NP_345380.1 similar to GB:M27869 SP:P17893 PID:142450 PID:143401 PID:1303922; identified by sequence similarity NP_345381.1 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue NP_345382.1 Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria. NP_345383.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis NP_345384.1 catalyzes the formation of phosphoenolpyruvate from pyruvate NP_345392.1 similar to GP:5823217; identified by sequence similarity NP_345400.1 identified by match to PFAM protein family HMM PF01276 NP_345402.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine NP_345404.1 similar to GB:D31783 PID:498170; identified by sequence similarity NP_345405.1 catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis NP_345406.1 identified by match to PFAM protein family HMM PF00795 NP_345412.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis NP_345415.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis NP_345416.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway NP_345417.1 identified by match to PFAM protein family HMM PF01089 NP_345419.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) NP_345420.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA. NP_345421.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA NP_345422.1 identified by match to PFAM protein family HMM PF00590 NP_345424.1 similar to PID:763133; identified by sequence similarity NP_345425.1 similar to PID:763133; identified by sequence similarity NP_345426.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine NP_345427.1 Catalyzes the phosphorylation of UMP to UDP NP_345428.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs NP_345431.1 similar to SP:P46343 PID:902050 PID:1303821 GB:AL009126; identified by sequence similarity NP_345436.1 identified by match to TIGR protein family HMM TIGR00361 NP_345440.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits NP_345441.1 identified by match to TIGR protein family HMM TIGR00001 NP_345442.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit NP_345443.1 identified by match to PFAM protein family HMM PF00903 NP_345444.1 responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+) NP_345445.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits NP_345447.1 similar to GP:6175915; identified by sequence similarity NP_345449.1 identified by match to PFAM protein family HMM PF01219 NP_345450.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome NP_345451.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases NP_345452.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis NP_345454.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_345456.1 identified by match to PFAM protein family HMM PF00773 NP_345457.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation NP_345458.1 with TehA confers resistance to tellurite NP_345459.1 similar to GP:3211759; identified by sequence similarity NP_345460.1 identified by match to PFAM protein family HMM PF01432 NP_345461.1 identified by match to PFAM protein family HMM PF01596 NP_345462.1 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein NP_345467.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis NP_345470.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine NP_345472.1 3'-5' exonuclease of DNA polymerase III YP_873930.1 Orf1 NP_345476.1 similar to GP:6714962; identified by sequence similarity NP_345478.1 identified by match to PFAM protein family HMM PF00324 NP_345479.1 identified by match to PFAM protein family HMM PF01297 NP_345484.1 catalyzes the release of the N-terminal amino acid from a tripeptide NP_345485.1 identified by match to TIGR protein family HMM TIGR00109 NP_345486.1 identified by match to PFAM protein family HMM PF01741 NP_345487.1 similar to GB:X73124 SP:P39602 PID:413958 GB:AL009126; identified by sequence similarity NP_345489.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde NP_345490.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis NP_345491.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE NP_345492.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown NP_345493.1 catalyzes the formation of thymidine 5'-phosphate from thymidine NP_345495.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 NP_345497.1 identified by match to PFAM protein family HMM PF01300 NP_345499.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate NP_345508.1 identified by match to PFAM protein family HMM PF01032 NP_345509.1 identified by match to PFAM protein family HMM PF01032 NP_345512.1 similar to GB:L17341 SP:Q07606 PID:304141; identified by sequence similarity NP_345519.1 similar to GP:7020551; identified by sequence similarity NP_345526.1 identified by match to PFAM protein family HMM PF02231 NP_345527.1 similar to GP:6009450; identified by sequence similarity NP_345528.1 similar to PID:951053; identified by sequence similarity NP_345529.1 similar to PID:951052; identified by sequence similarity NP_345541.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate NP_345545.1 synthesizes RNA primers at the replication forks NP_345546.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium NP_345550.1 similar to GB:AL009126; identified by sequence similarity NP_345552.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication NP_345554.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_345557.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides NP_345558.1 similar to PID:763133; identified by sequence similarity NP_345560.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase NP_345562.1 modulates transcription in response to the NADH/NAD(+) redox state NP_345567.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP NP_345570.1 catalyzes the phosphorylation of NAD to NADP NP_345572.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta NP_345576.1 identified by match to TIGR protein family HMM TIGR00061 NP_345578.1 involved in the peptidyltransferase reaction during translation NP_345581.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities NP_345588.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB NP_345592.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain NP_345593.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate NP_345595.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose NP_345598.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis NP_345606.1 similar to GP:1813342; identified by sequence similarity NP_345607.1 identified by match to PFAM protein family HMM PF01695 NP_345623.1 identified by match to PFAM protein family HMM PF00746 NP_345624.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) NP_345625.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids NP_345626.1 identified by match to PFAM protein family HMM PF00654 NP_345628.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS NP_345631.1 unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain NP_345633.1 identified by match to PFAM protein family HMM PF00676 NP_345635.1 identified by match to PFAM protein family HMM PF01554 NP_345636.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis NP_345638.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine NP_345640.1 identified by match to PFAM protein family HMM PF00702 NP_345643.1 similar to GP:4249624; identified by sequence similarity NP_345644.1 similar to GP:4249624; identified by sequence similarity NP_345648.1 Catalyzes the rate-limiting step in dNTP synthesis NP_345649.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE NP_345653.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside NP_345655.1 identified by match to PFAM protein family HMM PF02255 NP_345656.1 identified by match to PFAM protein family HMM PF00874 NP_345659.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources NP_345660.1 catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP NP_345661.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate NP_345662.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization NP_345663.1 similar to PID:763133; identified by sequence similarity NP_345667.1 binds to the ribosome on the universally-conserved alpha-sarcin loop NP_345669.1 identified by match to TIGR protein family HMM TIGR00634 NP_345671.1 similar to GB:M27869 SP:P19672 PID:142449 GB:AL009126; identified by sequence similarity NP_345672.1 identified by match to PFAM protein family HMM PF00348 NP_345673.1 catalyzes the bidirectional exonucleolytic cleavage of DNA NP_345674.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides NP_345675.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor NP_345679.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs NP_345680.1 similar to GP:6899348; identified by sequence similarity NP_345685.1 negatively supercoils closed circular double-stranded DNA NP_345686.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH NP_345687.1 similar to GP:4467889; identified by sequence similarity NP_345688.1 similar to GP:4467889; identified by sequence similarity NP_345690.1 similar to GP:7523564; identified by sequence similarity NP_345695.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate NP_345697.1 decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine. NP_345700.1 similar to GB:AE000512; identified by sequence similarity NP_345704.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion NP_345708.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate NP_345709.1 identified by match to PFAM protein family HMM PF00448 NP_345713.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity NP_345715.1 similar to GP:6967634; identified by sequence similarity NP_345724.1 similar to GP:1736520; identified by sequence similarity NP_345727.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity NP_345735.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers NP_345737.1 similar to GP:5001692; identified by sequence similarity NP_345738.1 similar to GP:5001693; identified by sequence similarity NP_345739.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity NP_345740.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers NP_345741.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis NP_345742.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity NP_345747.1 metalloprotease NP_345748.1 similar to PID:1519287; identified by sequence similarity NP_345749.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA NP_345751.1 identified by match to PFAM protein family HMM PF00448 NP_345757.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site NP_345758.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling NP_345759.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling NP_345760.1 identified by match to PFAM protein family HMM PF01817 NP_345761.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group NP_345762.1 identified by match to PFAM protein family HMM PF02272 NP_345763.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome NP_345769.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer NP_345771.1 similar to PID:763133; identified by sequence similarity NP_345772.1 similar to GP:4009479; identified by sequence similarity NP_345773.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex NP_345774.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex NP_345775.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex NP_345776.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the F subunit is part of the catalytic core of the ATP synthase complex NP_345779.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits NP_345780.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I is part of the membrane proton channel. NP_345786.1 identified by match to PFAM protein family HMM PF00474 NP_345787.1 identified by match to PFAM protein family HMM PF00701 NP_345788.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate NP_345790.1 similar to GB:AL123456; identified by sequence similarity NP_345795.1 similar to GP:8163721; identified by sequence similarity NP_345801.1 identified by match to PFAM protein family HMM PF00326 NP_345808.1 similar to GP:5257160; identified by sequence similarity NP_345810.1 similar to GP:8163721; identified by sequence similarity NP_345812.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors NP_345813.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit NP_345814.3 identified by match to PFAM protein family HMM PF01685 NP_345817.1 this fusion consists of methionine sulfoxide A reductase at the N-terminus and B at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion NP_345818.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate NP_345819.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine NP_345820.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence NP_345821.1 similar to GB:AL009126; identified by sequence similarity NP_345825.1 similar to GB:L42023 PID:1007735 PID:1221686 PID:1205775 PID:1574382; identified by sequence similarity NP_345827.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis NP_345829.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis NP_345831.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate NP_345832.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis NP_345833.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis NP_345834.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate NP_345835.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis NP_345840.1 converts 1,4-alpha-D-glucans to maltodextrin NP_345841.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_345848.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis NP_345850.1 identified by match to TIGR protein family HMM TIGR01252 NP_345853.1 similar to OMNI:NT01EC4457; identified by sequence similarity NP_345854.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation NP_345855.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation NP_345858.1 identified by match to PFAM protein family HMM PF01449 NP_345860.1 identified by match to PFAM protein family HMM PF01189 NP_345861.1 identified by match to PFAM protein family HMM PF00459 NP_345863.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress NP_345865.1 identified by match to PFAM protein family HMM PF00702 NP_345866.1 identified by match to PFAM protein family HMM PF01643 NP_345867.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III NP_345870.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein NP_345871.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system NP_345872.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA NP_345873.1 identified by match to PFAM protein family HMM PF01182 NP_345874.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step NP_345875.1 similar to GP:8163721; identified by sequence similarity NP_345877.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers NP_345878.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate NP_345884.1 identified by match to PFAM protein family HMM PF01136 NP_345886.1 identified by match to PFAM protein family HMM PF01136 NP_345893.1 similar to GB:AE000512; identified by sequence similarity NP_345895.1 similar to GP:8163721; identified by sequence similarity NP_345896.1 similar to GP:6009406; identified by sequence similarity NP_345897.1 This region contains a gene with one or more premature stops or frameshifts, and is not the result of a sequencing artifact; Resembles an IS679 element (IS66 family) NP_345899.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway NP_345903.1 similar to GP:5001711; identified by sequence similarity NP_345907.1 similar to GB:M24150 SP:P19579 PID:142633; identified by sequence similarity NP_345910.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_345912.1 identified by match to TIGR protein family HMM TIGR01292 NP_345917.1 identified by match to PFAM protein family HMM PF01035 NP_345920.1 similar to PID:662880 SP:P54176; identified by sequence similarity NP_345921.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate NP_345922.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate NP_345924.1 similar to PID:1906609; identified by sequence similarity NP_345925.1 similar to GB:L10328 SP:P31465 PID:290561 GB:U00096 PID:1790149; identified by sequence similarity NP_345926.1 similar to GB:L10328 SP:P31465 PID:290561 GB:U00096 PID:1790149; identified by sequence similarity NP_345928.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA NP_345929.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA NP_345933.1 identified by match to PFAM protein family HMM PF01522 NP_345941.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu NP_345943.1 identified by match to PFAM protein family HMM PF00230 NP_345944.1 identified by match to PFAM protein family HMM PF00746 NP_345948.1 similar to GP:5019553; identified by sequence similarity NP_345950.1 similar to GP:5929888; identified by sequence similarity NP_345954.1 similar to GP:8163721; identified by sequence similarity NP_345958.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane NP_345959.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit NP_345960.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit NP_345961.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit NP_345962.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex NP_345963.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. NP_345964.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 NP_345965.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0 NP_345967.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus NP_345971.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis NP_345972.1 similar to SP:Q09202 PID:643097; identified by sequence similarity NP_345975.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine NP_345979.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine NP_345981.1 similar to PID:1216309; identified by sequence similarity NP_345982.1 catalyzes the hydrolysis of pyrophosphate to phosphate NP_345987.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit NP_345988.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA NP_345989.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 NP_345990.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_345991.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate NP_345993.1 similar to GP:6562870; identified by sequence similarity NP_345996.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) NP_345997.1 YghU; B2989; one of eight glutathione transferase proteins from E. coli NP_345998.1 identified by match to PFAM protein family HMM PF00690 NP_345999.1 identified by match to PFAM protein family HMM PF01545 NP_346001.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity NP_346002.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis NP_346006.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate NP_346015.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential NP_346016.1 binds and unfolds substrates as part of the ClpXP protease NP_346019.1 identified by match to PFAM protein family HMM PF02047 NP_346020.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate NP_346022.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis NP_346023.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis NP_346029.1 identified by match to PFAM protein family HMM PF00857 NP_346030.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor NP_346034.1 Involved in disulfide oxidoreductase activity and electron transport NP_346037.1 identified by match to PFAM protein family HMM PF00557 NP_346038.1 similar to PID:1196899; identified by sequence similarity NP_346039.1 similar to GP:8163721; identified by sequence similarity NP_346042.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine NP_346043.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability NP_346047.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP NP_346051.1 identified by match to TIGR protein family HMM TIGR01179 NP_346052.1 identified by match to PFAM protein family HMM PF01266 NP_346054.1 identified by match to PFAM protein family HMM PF00452 NP_346056.1 similar to GP:3582249; identified by sequence similarity YP_873932.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase NP_346057.1 identified by match to PFAM protein family HMM PF00834 NP_346064.1 identified by match to PFAM protein family HMM PF01553 NP_346066.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence NP_346071.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) NP_346078.1 identified by match to PFAM protein family HMM PF01325 NP_346081.1 similar to GB:AL009126; identified by sequence similarity NP_346084.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine NP_346087.1 identified by match to PFAM protein family HMM PF01431 NP_346089.1 identified by match to PFAM protein family HMM PF01297 NP_346090.3 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein NP_346094.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate NP_346098.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme NP_346100.1 similar to GP:4009475; identified by sequence similarity NP_346102.1 similar to GP:4009473; identified by sequence similarity NP_346103.1 similar to GP:4009472; identified by sequence similarity NP_346104.1 identified by match to PFAM protein family HMM PF01168 NP_346105.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function NP_346106.1 identified by match to PFAM protein family HMM PF02491 NP_346109.1 identified by match to TIGR protein family HMM TIGR01143 NP_346110.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli NP_346111.1 involved in a recombinational process of DNA repair, independent of the recBC complex NP_346115.1 identified by match to PFAM protein family HMM PF00701 NP_346124.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate NP_346133.1 similar to GP:7160626; identified by sequence similarity NP_346135.1 catalyzes branch migration in Holliday junction intermediates NP_346136.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer NP_346137.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids NP_346138.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive NP_346139.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive NP_346140.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins NP_346141.1 similar to SP:Q09208 PID:643105; identified by sequence similarity NP_346147.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains NP_346148.1 identified by match to PFAM protein family HMM PF00881 NP_346149.1 Primosomal protein that may act to load helicase DnaC during DNA replication NP_346159.1 identified by match to PFAM protein family HMM PF02378 NP_346163.1 identified by match to PFAM protein family HMM PF00368 NP_346164.1 identified by match to PFAM protein family HMM PF01154 YP_873935.1 OrfA/OrfB NP_346170.1 identified by match to PFAM protein family HMM PF01029 NP_346171.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth NP_346172.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity NP_346173.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits NP_346174.1 Essential for recycling GMP and indirectly, cGMP NP_346181.1 identified by match to PFAM protein family HMM PF00857 NP_346183.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria NP_346185.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis NP_346187.1 identified by match to PFAM protein family HMM PF01544 NP_346188.1 identified by match to PFAM protein family HMM PF00924 NP_346191.1 similar to GB:AE000657; identified by sequence similarity NP_346194.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins NP_346195.1 similar to SP:P39684 PID:836778; identified by sequence similarity NP_346198.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase NP_346200.1 identified by match to PFAM protein family HMM PF01501 NP_346201.1 identified by match to PFAM protein family HMM PF01501 NP_346202.1 identified by match to PFAM protein family HMM PF01501 NP_346204.1 identified by match to PFAM protein family HMM PF01501 NP_346205.1 identified by match to PFAM protein family HMM PF01501 NP_346206.1 identified by match to PFAM protein family HMM PF00746 NP_346208.1 similar to GP:3980554; identified by sequence similarity NP_346210.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis NP_346211.1 identified by match to PFAM protein family HMM PF00230 NP_346213.1 identified by match to PFAM protein family HMM PF01432 NP_346214.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase NP_346215.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype NP_346224.1 similar to GP:758229; identified by sequence similarity NP_346233.1 similar to GP:409925; identified by sequence similarity NP_346237.1 similar to PID:2274940; identified by sequence similarity NP_346239.1 similar to GP:8918792; identified by sequence similarity NP_346241.1 identified by match to PFAM protein family HMM PF01478 NP_346244.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis NP_346245.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate NP_346246.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis NP_346247.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water NP_346248.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate NP_346249.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity NP_346250.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine NP_346255.1 similar to GP:4514548; identified by sequence similarity NP_346261.1 identified by match to TIGR protein family HMM TIGR01179 NP_346262.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism NP_346263.1 similar to GP:4530451; identified by sequence similarity NP_346270.1 identified by match to PFAM protein family HMM PF01041 NP_346271.1 identified by match to PFAM protein family HMM PF02397 NP_346274.1 similar to GB:AL009126; identified by sequence similarity NP_346278.1 identified by match to PFAM protein family HMM PF01260 NP_346279.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine NP_346281.1 similar to GB:M14340 SP:P09359 GB:S56948 PID:153607; identified by sequence similarity NP_346282.1 similar to SP:P09356 GB:S56948 PID:153606; identified by sequence similarity NP_346284.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism NP_346285.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism NP_346289.1 identified by match to PFAM protein family HMM PF01545 NP_346291.1 similar to GB:L42023 PID:1161423 PID:1221194 PID:1205327 SP:Q57425; identified by sequence similarity NP_346300.1 similar to PID:1652006; identified by sequence similarity NP_346301.1 identified by match to PFAM protein family HMM PF01032 NP_346302.1 identified by match to PFAM protein family HMM PF01032 NP_346307.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer NP_346308.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB NP_346309.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs NP_346312.3 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine NP_346313.1 converts L-glutamate to D-glutamate, a component of peptidoglycan NP_346329.1 similar to GB:M77351 SP:P27756 PID:153736; identified by sequence similarity NP_346331.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon NP_346333.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities NP_346336.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth NP_346337.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_873936.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA NP_346340.1 similar to SP:P29449 PID:20047; identified by sequence similarity NP_346344.1 identified by match to PFAM protein family HMM PF01569 NP_346351.1 identified by match to PFAM protein family HMM PF01289 NP_346355.1 similar to PID:763133; identified by sequence similarity NP_346356.1 similar to PID:763133; identified by sequence similarity NP_346364.1 similar to GB:M77223 PID:455322; identified by sequence similarity NP_346365.1 identified by match to PFAM protein family HMM PF01510 NP_346367.1 identified by match to PFAM protein family HMM PF01554 NP_346368.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs NP_346376.1 similar to PID:559859; identified by sequence similarity NP_346378.1 similar to SP:P37609 PID:433322; identified by sequence similarity NP_346386.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate NP_346387.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter NP_346388.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme NP_346393.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active NP_346395.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA NP_346397.1 catalyzes the formation of asparagine from aspartate and ammonia NP_346399.1 identified by match to PFAM protein family HMM PF01027 NP_346401.1 catalyzes the hydrolysis of acylphosphate NP_346402.1 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site NP_346403.1 identified by match to PFAM protein family HMM PF02143 NP_346410.1 identified by match to PFAM protein family HMM PF00834 NP_346411.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity NP_346412.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin NP_346415.1 similar to GP:3355783; identified by sequence similarity NP_346418.1 identified by match to PFAM protein family HMM PF01026 NP_346419.1 identified by match to PFAM protein family HMM PF00746 NP_346420.1 in Escherichia coli transcription of this gene is enhanced by polyamines NP_346421.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor NP_346423.1 identified by match to PFAM protein family HMM PF00582 NP_346425.1 identified by match to PFAM protein family HMM PF00710 NP_346433.1 similar to GP:5739312; identified by sequence similarity NP_346434.1 Modulates Rho-dependent transcription termination NP_346435.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force NP_346436.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif NP_346439.1 catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate NP_346443.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide NP_346451.1 identified by match to PFAM protein family HMM PF00465 NP_346453.1 identified by match to PFAM protein family HMM PF01451 NP_346454.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex NP_346455.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase NP_346457.1 identified by match to PFAM protein family HMM PF00874 NP_346458.1 catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways NP_346459.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate NP_346460.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization NP_346462.1 similar to GB:U14003 SP:P39302 PID:537035 GB:U00096 PID:1790638; identified by sequence similarity NP_346463.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr NP_346467.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates NP_346469.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA NP_346471.1 similar to GP:5103043; identified by sequence similarity NP_346474.1 similar to GP:3211751; identified by sequence similarity NP_346475.1 similar to GP:3211750; identified by sequence similarity NP_346480.1 identified by match to TIGR protein family HMM TIGR00221 NP_346482.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) NP_346484.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline NP_346487.1 identified by match to PFAM protein family HMM PF00702 NP_346488.1 identified by match to PFAM protein family HMM PF01554 NP_346489.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine NP_346492.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation NP_346493.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family NP_346499.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase NP_346500.1 similar to PID:763133; identified by sequence similarity NP_346507.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation NP_346508.1 similar to OMNI:NT01EC4457; identified by sequence similarity NP_346510.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate NP_346511.1 identified by match to TIGR protein family HMM TIGR01099 NP_346519.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) NP_346522.1 similar to GB:D28496 SP:P36999 PID:460699 GB:U00096 PID:1736466; identified by sequence similarity NP_346526.1 amylomaltase; acts to release glucose from maltodextrins NP_346530.1 similar to GB:L21856 SP:Q08510 PID:347186; identified by sequence similarity NP_346533.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes NP_346535.1 similar to PID:1402529; identified by sequence similarity NP_346540.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG NP_346544.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis NP_346545.1 similar to GB:AE000512; identified by sequence similarity NP_346546.1 identified by match to PFAM protein family HMM PF00456 NP_346547.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr NP_346548.1 similar to GB:U14003 SP:P39302 PID:537035 GB:U00096 PID:1790638; identified by sequence similarity NP_346551.1 similar to GP:9967664; identified by sequence similarity NP_346552.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not NP_346553.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif NP_346555.1 similar to PID:763133; identified by sequence similarity NP_346558.1 similar to SP:P43077 PID:432354; identified by sequence similarity NP_346565.1 catalyzes the degradation of arginine to citruline and ammonia NP_346566.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway NP_346567.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP NP_346571.1 identified by match to PFAM protein family HMM PF00465 NP_346572.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose NP_346573.1 similar to GP:9651025; identified by sequence similarity NP_346579.1 similar to GB:L42023 SP:P44778 PID:1005441 PID:1220689 PID:1204863; identified by sequence similarity NP_346580.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate NP_346583.1 identified by match to PFAM protein family HMM PF01297 NP_346584.1 identified by match to PFAM protein family HMM PF00950 NP_346587.1 similar to GP:6456613; identified by sequence similarity NP_346588.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid NP_346589.1 similar to GP:2952530; identified by sequence similarity NP_346590.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid NP_346592.1 similar to GP:8163721; identified by sequence similarity NP_346595.1 identified by match to PFAM protein family HMM PF00230 NP_346597.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP NP_346598.1 similar to GP:409925; identified by sequence similarity NP_346599.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers NP_346600.1 identified by match to PFAM protein family HMM PF01207 NP_346606.1 similar to GB:D26185 SP:P37568 PID:467471 GB:AL009126; identified by sequence similarity NP_346608.1 similar to GB:AE001363; identified by sequence similarity NP_346614.1 unwinds double stranded DNA NP_346615.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk NP_346616.1 identified by match to PFAM protein family HMM PF02272 NP_346618.1 identified by match to TIGR protein family HMM TIGR00201 NP_346621.1 identified by match to TIGR protein family HMM TIGR01139 NP_346622.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu NP_346623.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit NP_346624.1 similar to GB:M60178 SP:P22865 PID:149525 PID:512521; identified by sequence similarity NP_346625.1 similar to GP:9246949; identified by sequence similarity NP_346626.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall NP_346628.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene NP_346629.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene NP_346630.1 identified by match to PFAM protein family HMM PF01066 NP_346632.1 identified by match to PFAM protein family HMM PF00675 NP_346635.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA NP_346636.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate NP_346637.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA NP_346644.1 similar to SP:P72507; identified by sequence similarity NP_346645.1 SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA NP_346647.1 identified by match to PFAM protein family HMM PF02195