-- dump date 20140620_085416 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 170187000001 SEQ_END SEQ_END NC_003028.3 2160842 2160842 DR NC_003028.3; contig end 2160842..2160842 Streptococcus pneumoniae TIGR4 NP_344554.1 CDS dnaA NC_003028.3 197 1558 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosome replication initiator DnaA 197..1558 Streptococcus pneumoniae TIGR4 929738 NP_344555.1 CDS SP_0002 NC_003028.3 1717 2853 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1717..2853 Streptococcus pneumoniae TIGR4 929739 NP_344556.1 CDS SP_0003 NC_003028.3 2864 3112 D hypothetical protein 2864..3112 Streptococcus pneumoniae TIGR4 929740 NP_344557.1 CDS SP_0004 NC_003028.3 3196 4311 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 3196..4311 Streptococcus pneumoniae TIGR4 929741 NP_344558.1 CDS SP_0005 NC_003028.3 4382 4951 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4382..4951 Streptococcus pneumoniae TIGR4 929742 NP_344559.1 CDS SP_0006 NC_003028.3 4952 8461 D identified by match to TIGR protein family HMM TIGR00580; transcription-repair coupling factor 4952..8461 Streptococcus pneumoniae TIGR4 929743 NP_344560.1 CDS SP_0007 NC_003028.3 8519 8785 D S4 domain-containing protein 8519..8785 Streptococcus pneumoniae TIGR4 929744 NP_344561.1 CDS SP_0008 NC_003028.3 8778 9146 D hypothetical protein 8778..9146 Streptococcus pneumoniae TIGR4 929745 NP_344562.1 CDS SP_0009 NC_003028.3 9151 9273 D hypothetical protein 9151..9273 Streptococcus pneumoniae TIGR4 929746 NP_344563.1 CDS SP_0010 NC_003028.3 9266 10534 D similar to PID:683698; identified by sequence similarity; hypothetical protein 9266..10534 Streptococcus pneumoniae TIGR4 929747 NP_344564.1 CDS SP_0011 NC_003028.3 10531 11808 D MesJ/Ycf62 family protein 10531..11808 Streptococcus pneumoniae TIGR4 929748 NP_344565.1 CDS SP_0012 NC_003028.3 11812 12354 D Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively; hypoxanthine-guanine phosphoribosyltransferase 11812..12354 Streptococcus pneumoniae TIGR4 929749 NP_344566.1 CDS SP_0013 NC_003028.3 12370 14328 D identified by match to PFAM protein family HMM PF01434; cell division protein FtsH 12370..14328 Streptococcus pneumoniae TIGR4 929750 NP_344567.1 CDS SP_0014 NC_003028.3 14450 14929 D similar to GP:5739312; identified by sequence similarity; transcriptional regulator ComX1 14450..14929 Streptococcus pneumoniae TIGR4 929752 NP_344568.1 CDS SP_0015 NC_003028.3 20404 20820 D IS630-Spn1, transposase Orf1 20404..20820 Streptococcus pneumoniae TIGR4 929762 NP_344569.1 CDS SP_0016 NC_003028.3 20929 21267 D IS630-Spn1, transposase Orf2 20929..21267 Streptococcus pneumoniae TIGR4 929763 NP_344570.1 CDS SP_0018 NC_003028.3 22359 22601 D hypothetical protein 22359..22601 Streptococcus pneumoniae TIGR4 929765 NP_344571.1 CDS SP_0019 NC_003028.3 22832 24118 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 22832..24118 Streptococcus pneumoniae TIGR4 929766 NP_344572.1 CDS SP_0020 NC_003028.3 24319 24786 D cytidine/deoxycytidylate deaminase 24319..24786 Streptococcus pneumoniae TIGR4 929767 NP_344573.1 CDS dut NC_003028.3 24973 25416 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 24973..25416 Streptococcus pneumoniae TIGR4 929768 NP_344574.1 CDS SP_0022 NC_003028.3 25418 25933 D hypothetical protein 25418..25933 Streptococcus pneumoniae TIGR4 929769 NP_344575.1 CDS SP_0024 NC_003028.3 27381 27878 D hypothetical protein 27381..27878 Streptococcus pneumoniae TIGR4 929771 NP_344576.1 CDS SP_0025 NC_003028.3 27903 28112 D hypothetical protein 27903..28112 Streptococcus pneumoniae TIGR4 929772 NP_344577.1 CDS SP_0026 NC_003028.3 28094 28717 D hypothetical protein 28094..28717 Streptococcus pneumoniae TIGR4 929773 NP_344578.1 CDS SP_0027 NC_003028.3 28862 29830 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 28862..29830 Streptococcus pneumoniae TIGR4 929774 NP_344579.1 CDS SP_0029 NC_003028.3 30372 30605 R hypothetical protein complement(30372..30605) Streptococcus pneumoniae TIGR4 929776 NP_344580.1 CDS SP_0030 NC_003028.3 30563 30889 R similar to GP:1469653; identified by sequence similarity; competence-induced protein Ccs16 complement(30563..30889) Streptococcus pneumoniae TIGR4 929777 NP_344581.1 CDS SP_0031 NC_003028.3 30929 31243 R hypothetical protein complement(30929..31243) Streptococcus pneumoniae TIGR4 929778 NP_344582.1 CDS SP_0032 NC_003028.3 31535 34168 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 31535..34168 Streptococcus pneumoniae TIGR4 929779 NP_344583.1 CDS SP_0033 NC_003028.3 34253 34690 D hypothetical protein 34253..34690 Streptococcus pneumoniae TIGR4 929780 NP_344584.1 CDS SP_0034 NC_003028.3 35009 36019 R hypothetical protein complement(35009..36019) Streptococcus pneumoniae TIGR4 929781 NP_344585.1 CDS SP_0035 NC_003028.3 36168 37337 D catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 36168..37337 Streptococcus pneumoniae TIGR4 929782 NP_344586.1 CDS recO NC_003028.3 37334 38104 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 37334..38104 Streptococcus pneumoniae TIGR4 929785 NP_344587.1 CDS SP_0037 NC_003028.3 38101 39093 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 38101..39093 Streptococcus pneumoniae TIGR4 929786 NP_344588.1 CDS SP_0038 NC_003028.3 39099 39332 D identified by match to PFAM protein family HMM PF00550; acyl carrier protein 39099..39332 Streptococcus pneumoniae TIGR4 929788 NP_344589.1 CDS SP_0040 NC_003028.3 39716 39841 R hypothetical protein complement(39716..39841) Streptococcus pneumoniae TIGR4 929790 NP_344590.1 CDS SP_0041 NC_003028.3 39871 40101 D similar to GP:9798576; identified by sequence similarity; bacteriocin BlpU 39871..40101 Streptococcus pneumoniae TIGR4 929791 NP_344591.1 CDS SP_0042 NC_003028.3 40816 42969 D competence factor transporting ATP-binding protein/permease ComA 40816..42969 Streptococcus pneumoniae TIGR4 929792 NP_344592.1 CDS SP_0043 NC_003028.3 42982 44331 D competence factor transport protein ComB 42982..44331 Streptococcus pneumoniae TIGR4 929793 NP_344593.1 CDS SP_0044 NC_003028.3 44501 45208 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 44501..45208 Streptococcus pneumoniae TIGR4 929794 NP_344594.1 CDS SP_0045 NC_003028.3 45410 49135 D identified by match to PFAM protein family HMM PF00586; phosphoribosylformylglycinamidine synthase 45410..49135 Streptococcus pneumoniae TIGR4 929795 NP_344595.1 CDS SP_0046 NC_003028.3 49228 50670 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 49228..50670 Streptococcus pneumoniae TIGR4 929796 NP_344596.1 CDS SP_0047 NC_003028.3 50889 51911 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 50889..51911 Streptococcus pneumoniae TIGR4 929797 NP_344597.1 CDS purN NC_003028.3 51908 52453 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 51908..52453 Streptococcus pneumoniae TIGR4 929798 NP_344598.1 CDS SP_0049 NC_003028.3 52537 53046 D similar to GP:6448500; identified by sequence similarity; vanZ protein 52537..53046 Streptococcus pneumoniae TIGR4 929801 NP_344599.1 CDS purH NC_003028.3 53071 54618 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 53071..54618 Streptococcus pneumoniae TIGR4 929804 NP_344600.1 CDS SP_0051 NC_003028.3 54740 56002 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 54740..56002 Streptococcus pneumoniae TIGR4 929805 NP_344601.1 CDS SP_0052 NC_003028.3 56259 56375 D hypothetical protein 56259..56375 Streptococcus pneumoniae TIGR4 929806 NP_344602.1 CDS SP_0053 NC_003028.3 56405 56893 D Catalyzes a step in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase catalytic subunit 56405..56893 Streptococcus pneumoniae TIGR4 929808 NP_344603.1 CDS SP_0054 NC_003028.3 56880 57971 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 56880..57971 Streptococcus pneumoniae TIGR4 929809 NP_344604.1 CDS SP_0055 NC_003028.3 57981 58208 D hypothetical protein 57981..58208 Streptococcus pneumoniae TIGR4 929810 NP_344605.1 CDS SP_0056 NC_003028.3 58271 59569 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 58271..59569 Streptococcus pneumoniae TIGR4 929811 NP_344606.1 CDS SP_0057 NC_003028.3 59624 63562 R identified by match to PFAM protein family HMM PF00746; beta-N-acetylhexosaminidase complement(59624..63562) Streptococcus pneumoniae TIGR4 929812 NP_344607.1 CDS SP_0058 NC_003028.3 63890 64606 R GntR family transcriptional regulator complement(63890..64606) Streptococcus pneumoniae TIGR4 929814 NP_344608.1 CDS SP_0059 NC_003028.3 64593 64694 D hypothetical protein 64593..64694 Streptococcus pneumoniae TIGR4 929815 NP_344609.1 CDS SP_0060 NC_003028.3 64955 66742 D identified by match to PFAM protein family HMM PF01301; Beta-galactosidase 3 64955..66742 Streptococcus pneumoniae TIGR4 929817 NP_344610.1 CDS SP_0061 NC_003028.3 66739 67215 D PTS system transporter subunit IIB 66739..67215 Streptococcus pneumoniae TIGR4 929820 NP_344611.1 CDS SP_0062 NC_003028.3 67243 68148 D PTS system transporter subunit IIC 67243..68148 Streptococcus pneumoniae TIGR4 929821 NP_344612.1 CDS SP_0063 NC_003028.3 68135 68950 D PTS system transporter subunit IID 68135..68950 Streptococcus pneumoniae TIGR4 929823 NP_344613.1 CDS SP_0064 NC_003028.3 68957 69361 D PTS system transporter subunit IIA 68957..69361 Streptococcus pneumoniae TIGR4 929825 NP_344614.1 CDS SP_0065 NC_003028.3 69660 70826 D sugar isomerase 69660..70826 Streptococcus pneumoniae TIGR4 929827 NP_344615.1 CDS SP_0066 NC_003028.3 70942 71979 D identified by match to PFAM protein family HMM PF01263; aldose 1-epimerase 70942..71979 Streptococcus pneumoniae TIGR4 929828 NP_344616.1 CDS SP_0067 NC_003028.3 72141 72401 D hypothetical protein 72141..72401 Streptococcus pneumoniae TIGR4 929829 NP_344617.1 CDS SP_0068 NC_003028.3 72456 72653 D hypothetical protein 72456..72653 Streptococcus pneumoniae TIGR4 929830 NP_344618.1 CDS SP_0069 NC_003028.3 72674 73309 D choline binding protein I 72674..73309 Streptococcus pneumoniae TIGR4 929834 NP_344619.1 CDS SP_0070 NC_003028.3 73353 73454 D hypothetical protein 73353..73454 Streptococcus pneumoniae TIGR4 929835 NP_344620.1 CDS SP_0071 NC_003028.3 73761 79331 D immunoglobulin A1 protease 73761..79331 Streptococcus pneumoniae TIGR4 929838 NP_344621.1 CDS SP_0072 NC_003028.3 79434 79547 D hypothetical protein 79434..79547 Streptococcus pneumoniae TIGR4 929839 NP_344622.1 CDS SP_0073 NC_003028.3 79687 80541 D hypothetical protein 79687..80541 Streptococcus pneumoniae TIGR4 929841 NP_344623.1 CDS SP_0074 NC_003028.3 80647 81204 D acetyltransferase 80647..81204 Streptococcus pneumoniae TIGR4 929842 NP_344624.1 CDS SP_0075 NC_003028.3 81481 82185 D identified by match to PFAM protein family HMM PF01048; phosphorylase Pnp/Udp family protein 81481..82185 Streptococcus pneumoniae TIGR4 929844 NP_344625.1 CDS SP_0076 NC_003028.3 82590 82682 R hypothetical protein complement(82590..82682) Streptococcus pneumoniae TIGR4 929845 NP_344626.1 CDS SP_0077 NC_003028.3 82659 82817 D hypothetical protein 82659..82817 Streptococcus pneumoniae TIGR4 929846 NP_344627.1 CDS SP_0078 NC_003028.3 82798 84177 D Trk family potassium uptake protein 82798..84177 Streptococcus pneumoniae TIGR4 929848 NP_344628.1 CDS SP_0079 NC_003028.3 84191 84856 D identified by match to PFAM protein family HMM PF02254; Trk family potassium uptake protein 84191..84856 Streptococcus pneumoniae TIGR4 929849 NP_344629.1 CDS SP_0080 NC_003028.3 84877 84984 D hypothetical protein 84877..84984 Streptococcus pneumoniae TIGR4 929850 NP_344630.1 CDS SP_0082 NC_003028.3 86298 88871 D identified by match to PFAM protein family HMM PF00746; cell wall surface anchor family protein 86298..88871 Streptococcus pneumoniae TIGR4 929852 NP_344631.1 CDS SP_0083 NC_003028.3 89038 89736 D DNA-binding response regulator 89038..89736 Streptococcus pneumoniae TIGR4 929853 NP_344632.1 CDS SP_0084 NC_003028.3 89733 90785 D sensor histidine kinase 89733..90785 Streptococcus pneumoniae TIGR4 929854 NP_344633.1 CDS rpsD NC_003028.3 90980 91591 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 90980..91591 Streptococcus pneumoniae TIGR4 929855 NP_344634.1 CDS SP_0087 NC_003028.3 92025 92165 R hypothetical protein complement(92025..92165) Streptococcus pneumoniae TIGR4 929858 NP_344635.1 CDS SP_0088 NC_003028.3 92236 92505 D hypothetical protein 92236..92505 Streptococcus pneumoniae TIGR4 929859 NP_344636.1 CDS SP_0089 NC_003028.3 92585 92680 D hypothetical protein 92585..92680 Streptococcus pneumoniae TIGR4 929860 NP_344637.1 CDS SP_0090 NC_003028.3 92969 93928 D ABC transporter permease 92969..93928 Streptococcus pneumoniae TIGR4 929861 NP_344638.1 CDS SP_0091 NC_003028.3 93942 94865 D ABC transporter permease 93942..94865 Streptococcus pneumoniae TIGR4 929863 NP_344639.1 CDS SP_0092 NC_003028.3 95123 96598 D ABC transporter substrate-binding protein 95123..96598 Streptococcus pneumoniae TIGR4 929866 NP_344640.1 CDS SP_0093 NC_003028.3 96628 96741 R hypothetical protein complement(96628..96741) Streptococcus pneumoniae TIGR4 929867 NP_344641.1 CDS SP_0094 NC_003028.3 96713 96820 D hypothetical protein 96713..96820 Streptococcus pneumoniae TIGR4 929868 NP_344642.1 CDS SP_0095 NC_003028.3 96870 97856 D hypothetical protein 96870..97856 Streptococcus pneumoniae TIGR4 929869 NP_344643.1 CDS SP_0096 NC_003028.3 98131 98991 D hypothetical protein 98131..98991 Streptococcus pneumoniae TIGR4 929870 NP_344644.1 CDS SP_0097 NC_003028.3 99169 100233 R similar to GP:8953759; identified by sequence similarity; hypothetical protein complement(99169..100233) Streptococcus pneumoniae TIGR4 929872 NP_344645.1 CDS SP_0098 NC_003028.3 100296 101207 R hypothetical protein complement(100296..101207) Streptococcus pneumoniae TIGR4 929873 NP_344646.1 CDS SP_0099 NC_003028.3 101200 101793 R hypothetical protein complement(101200..101793) Streptococcus pneumoniae TIGR4 929874 NP_344647.1 CDS SP_0100 NC_003028.3 101780 102106 R hypothetical protein complement(101780..102106) Streptococcus pneumoniae TIGR4 929875 NP_344648.1 CDS SP_0101 NC_003028.3 102245 103411 R transporter complement(102245..103411) Streptococcus pneumoniae TIGR4 929876 NP_344649.1 CDS SP_0102 NC_003028.3 103562 104626 D glycosyl transferase family protein 103562..104626 Streptococcus pneumoniae TIGR4 929877 NP_344650.1 CDS SP_0103 NC_003028.3 104668 106518 D capsular polysaccharide biosynthesis protein 104668..106518 Streptococcus pneumoniae TIGR4 929878 NP_344651.1 CDS SP_0104 NC_003028.3 106956 107588 R identified by match to PFAM protein family HMM PF00702; HAD superfamily hydrolase complement(106956..107588) Streptococcus pneumoniae TIGR4 929880 NP_344652.1 CDS SP_0105 NC_003028.3 107610 108482 R identified by match to TIGR protein family HMM TIGR00718; L-serine dehydratase, iron-sulfur-dependent subunit alpha complement(107610..108482) Streptococcus pneumoniae TIGR4 929882 NP_344653.1 CDS SP_0106 NC_003028.3 108491 109162 R identified by match to TIGR protein family HMM TIGR00719; L-serine dehydratase, iron-sulfur-dependent subunit beta complement(108491..109162) Streptococcus pneumoniae TIGR4 929883 NP_344654.1 CDS SP_0107 NC_003028.3 109404 109991 D LysM domain-containing protein 109404..109991 Streptococcus pneumoniae TIGR4 929884 NP_344655.1 CDS SP_0108 NC_003028.3 110043 110363 R hypothetical protein complement(110043..110363) Streptococcus pneumoniae TIGR4 929885 NP_344656.1 CDS SP_0109 NC_003028.3 110794 111081 D similar to GP:3355782; identified by sequence similarity; bacteriocin 110794..111081 Streptococcus pneumoniae TIGR4 929886 NP_344657.1 CDS SP_0110 NC_003028.3 111157 113241 D hypothetical protein 111157..113241 Streptococcus pneumoniae TIGR4 929888 NP_344658.1 CDS SP_0111 NC_003028.3 113238 113879 D amino acid ABC transporter ATP-binding protein 113238..113879 Streptococcus pneumoniae TIGR4 929889 NP_344659.1 CDS SP_0112 NC_003028.3 114086 114892 D amino acid ABC transporter substrate-binding protein 114086..114892 Streptococcus pneumoniae TIGR4 929890 NP_344660.1 CDS SP_0114 NC_003028.3 115515 115835 R hypothetical protein complement(115515..115835) Streptococcus pneumoniae TIGR4 929892 NP_344661.1 CDS SP_0115 NC_003028.3 116593 116973 D hypothetical protein 116593..116973 Streptococcus pneumoniae TIGR4 929893 NP_344662.1 CDS SP_0116 NC_003028.3 117625 117870 D hypothetical protein 117625..117870 Streptococcus pneumoniae TIGR4 929894 NP_344663.1 CDS SP_0117 NC_003028.3 118423 120657 D surface protein A 118423..120657 Streptococcus pneumoniae TIGR4 929896 NP_344664.1 CDS mnmA NC_003028.3 121058 122179 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 121058..122179 Streptococcus pneumoniae TIGR4 929897 NP_344665.1 CDS SP_0119 NC_003028.3 122320 122775 D MutT/nudix family protein 122320..122775 Streptococcus pneumoniae TIGR4 929898 NP_344666.1 CDS SP_0120 NC_003028.3 122785 124698 D GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 122785..124698 Streptococcus pneumoniae TIGR4 929899 NP_344667.1 CDS SP_0121 NC_003028.3 125051 126730 R identified by match to PFAM protein family HMM PF02147; metallo-beta-lactamase superfamily protein complement(125051..126730) Streptococcus pneumoniae TIGR4 929900 NP_344668.1 CDS SP_0122 NC_003028.3 126732 126965 R hypothetical protein complement(126732..126965) Streptococcus pneumoniae TIGR4 929901 NP_344669.1 CDS SP_0123 NC_003028.3 127291 127536 R similar to SP:P39554 PID:456140; identified by sequence similarity; competence-induced protein Ccs1 complement(127291..127536) Streptococcus pneumoniae TIGR4 929902 NP_344670.1 CDS SP_0124 NC_003028.3 127783 127935 R hypothetical protein complement(127783..127935) Streptococcus pneumoniae TIGR4 929905 NP_344671.1 CDS SP_0125 NC_003028.3 127937 128122 R hypothetical protein complement(127937..128122) Streptococcus pneumoniae TIGR4 929906 NP_344672.1 CDS SP_0126 NC_003028.3 128097 128204 D hypothetical protein 128097..128204 Streptococcus pneumoniae TIGR4 929907 NP_344673.1 CDS SP_0127 NC_003028.3 128300 128983 D hypothetical protein 128300..128983 Streptococcus pneumoniae TIGR4 929908 NP_344674.1 CDS SP_0128 NC_003028.3 128980 129417 D ribosomal-protein-alanine acetyltransferase 128980..129417 Streptococcus pneumoniae TIGR4 929911 NP_344675.1 CDS SP_0129 NC_003028.3 129407 130417 D in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 129407..130417 Streptococcus pneumoniae TIGR4 929912 NP_344676.1 CDS SP_0133 NC_003028.3 133024 133587 D hypothetical protein 133024..133587 Streptococcus pneumoniae TIGR4 929918 NP_344677.1 CDS SP_0134 NC_003028.3 133565 133771 D hypothetical protein 133565..133771 Streptococcus pneumoniae TIGR4 929920 NP_344678.1 CDS SP_0135 NC_003028.3 133795 134238 D glycosyl transferase family protein 133795..134238 Streptococcus pneumoniae TIGR4 929921 NP_344679.1 CDS SP_0136 NC_003028.3 134231 135106 D glycosyl transferase family protein 134231..135106 Streptococcus pneumoniae TIGR4 929922 NP_344680.1 CDS SP_0137 NC_003028.3 135193 136809 D ABC transporter ATP-binding protein 135193..136809 Streptococcus pneumoniae TIGR4 929923 NP_344681.1 CDS SP_0138 NC_003028.3 137031 137498 D hypothetical protein 137031..137498 Streptococcus pneumoniae TIGR4 929924 NP_344682.1 CDS SP_0139 NC_003028.3 137504 138259 D similar to GP:4689219; identified by sequence similarity; hypothetical protein 137504..138259 Streptococcus pneumoniae TIGR4 929926 NP_344683.1 CDS SP_0141 NC_003028.3 139839 140702 D transcriptional regulator 139839..140702 Streptococcus pneumoniae TIGR4 929928 NP_344684.1 CDS SP_0142 NC_003028.3 140988 141221 D hypothetical protein 140988..141221 Streptococcus pneumoniae TIGR4 929930 NP_344685.1 CDS SP_0143 NC_003028.3 141243 141920 D similar to GB:AL009126; identified by sequence similarity; hypothetical protein 141243..141920 Streptococcus pneumoniae TIGR4 929931 NP_344686.1 CDS SP_0144 NC_003028.3 141932 142597 D hypothetical protein 141932..142597 Streptococcus pneumoniae TIGR4 929932 NP_344687.1 CDS SP_0145 NC_003028.3 142669 143895 D hypothetical protein 142669..143895 Streptococcus pneumoniae TIGR4 929933 NP_344688.1 CDS SP_0146 NC_003028.3 144440 145096 D hypothetical protein 144440..145096 Streptococcus pneumoniae TIGR4 929934 NP_344689.1 CDS SP_0147 NC_003028.3 145086 145295 D hypothetical protein 145086..145295 Streptococcus pneumoniae TIGR4 929935 NP_344690.1 CDS SP_0148 NC_003028.3 145513 146343 D ABC transporter substrate-binding protein 145513..146343 Streptococcus pneumoniae TIGR4 929936 NP_344691.1 CDS SP_0149 NC_003028.3 146497 147351 D lipoprotein 146497..147351 Streptococcus pneumoniae TIGR4 929937 NP_344692.1 CDS SP_0150 NC_003028.3 147451 148824 D hypothetical protein 147451..148824 Streptococcus pneumoniae TIGR4 929938 NP_344693.1 CDS SP_0151 NC_003028.3 148817 149878 D ABC transporter ATP-binding protein 148817..149878 Streptococcus pneumoniae TIGR4 929939 NP_344694.1 CDS SP_0152 NC_003028.3 149880 150572 D ABC transporter permease 149880..150572 Streptococcus pneumoniae TIGR4 929940 NP_344695.1 CDS SP_0153 NC_003028.3 150602 151171 R hypothetical protein complement(150602..151171) Streptococcus pneumoniae TIGR4 929941 NP_344696.1 CDS SP_0154 NC_003028.3 151306 151920 D hypothetical protein 151306..151920 Streptococcus pneumoniae TIGR4 929942 NP_344697.1 CDS SP_0155 NC_003028.3 151922 153568 D sensor histidine kinase 151922..153568 Streptococcus pneumoniae TIGR4 929945 NP_344698.1 CDS SP_0156 NC_003028.3 153580 154866 D DNA-binding response regulator 153580..154866 Streptococcus pneumoniae TIGR4 929947 NP_344699.1 CDS SP_0157 NC_003028.3 154870 155451 D hypothetical protein 154870..155451 Streptococcus pneumoniae TIGR4 929948 NP_344700.1 CDS SP_0158 NC_003028.3 155529 155999 D has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; flavoprotein NrdI 155529..155999 Streptococcus pneumoniae TIGR4 929949 NP_344701.1 CDS SP_0159 NC_003028.3 156292 157554 R hypothetical protein complement(156292..157554) Streptococcus pneumoniae TIGR4 929950 NP_344702.1 CDS SP_0160 NC_003028.3 157864 158322 R similar to GP:6690328; identified by sequence similarity; hypothetical protein complement(157864..158322) Streptococcus pneumoniae TIGR4 929951 NP_344703.1 CDS SP_0161 NC_003028.3 158319 158759 R similar to PID:1196936; identified by sequence similarity; hypothetical protein complement(158319..158759) Streptococcus pneumoniae TIGR4 929952 NP_344704.1 CDS SP_0162 NC_003028.3 158849 158944 D hypothetical protein 158849..158944 Streptococcus pneumoniae TIGR4 929953 NP_344705.1 CDS SP_0163 NC_003028.3 159192 160058 D transcriptional regulator PlcR 159192..160058 Streptococcus pneumoniae TIGR4 929954 NP_344706.1 CDS SP_0164 NC_003028.3 160211 160339 D hypothetical protein 160211..160339 Streptococcus pneumoniae TIGR4 929955 NP_344707.1 CDS SP_0165 NC_003028.3 160384 160941 D similar to SP:P30197 GB:X62386 PID:46970; identified by sequence similarity; flavoprotein 160384..160941 Streptococcus pneumoniae TIGR4 929956 NP_344708.1 CDS SP_0166 NC_003028.3 161162 162268 D pyridoxal-dependent decarboxylase 161162..162268 Streptococcus pneumoniae TIGR4 929958 NP_344709.1 CDS SP_0167 NC_003028.3 162244 163635 D hypothetical protein 162244..163635 Streptococcus pneumoniae TIGR4 929959 NP_344710.1 CDS SP_0168 NC_003028.3 163632 164810 D macrolide efflux protein 163632..164810 Streptococcus pneumoniae TIGR4 929960 NP_344711.1 CDS SP_0170 NC_003028.3 165095 165211 D hypothetical protein 165095..165211 Streptococcus pneumoniae TIGR4 929962 NP_344712.1 CDS SP_0171 NC_003028.3 165235 165468 D ROK family protein 165235..165468 Streptococcus pneumoniae TIGR4 929963 NP_344713.1 CDS SP_0172 NC_003028.3 165586 165690 D hypothetical protein 165586..165690 Streptococcus pneumoniae TIGR4 929964 NP_344714.1 CDS mutL NC_003028.3 165751 167700 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 165751..167700 Streptococcus pneumoniae TIGR4 929965 NP_344715.1 CDS SP_0174 NC_003028.3 167836 167928 R hypothetical protein complement(167836..167928) Streptococcus pneumoniae TIGR4 929966 NP_344716.1 CDS ribH NC_003028.3 168025 168492 R RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase complement(168025..168492) Streptococcus pneumoniae TIGR4 929967 NP_344717.1 CDS SP_0176 NC_003028.3 168493 169698 R identified by match to PFAM protein family HMM PF00926; 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(168493..169698) Streptococcus pneumoniae TIGR4 929968 NP_344718.1 CDS SP_0177 NC_003028.3 169718 170353 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(169718..170353) Streptococcus pneumoniae TIGR4 929969 NP_344719.1 CDS SP_0178 NC_003028.3 170338 171438 R identified by match to TIGR protein family HMM TIGR00326; riboflavin biosynthesis protein RibD complement(170338..171438) Streptococcus pneumoniae TIGR4 929972 NP_344720.1 CDS ruvA NC_003028.3 171843 172436 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 171843..172436 Streptococcus pneumoniae TIGR4 929973 NP_344721.1 CDS SP_0180 NC_003028.3 172473 173009 D DNA-3-methyladenine glycosylase I 172473..173009 Streptococcus pneumoniae TIGR4 929974 NP_344722.1 CDS SP_0181 NC_003028.3 173006 173683 D hypothetical protein 173006..173683 Streptococcus pneumoniae TIGR4 929975 NP_344723.1 CDS SP_0182 NC_003028.3 173820 174851 R identified by match to PFAM protein family HMM PF02016; methylcrotonoyl-CoA carboxylase complement(173820..174851) Streptococcus pneumoniae TIGR4 929976 NP_344724.1 CDS SP_0183 NC_003028.3 175039 175134 R hypothetical protein complement(175039..175134) Streptococcus pneumoniae TIGR4 929977 NP_344725.1 CDS SP_0184 NC_003028.3 175106 175810 R hypothetical protein complement(175106..175810) Streptococcus pneumoniae TIGR4 929978 NP_344726.1 CDS SP_0185 NC_003028.3 175801 176745 R identified by match to PFAM protein family HMM PF01544; magnesium transporter CorA family protein complement(175801..176745) Streptococcus pneumoniae TIGR4 929979 NP_344727.1 CDS uvrA NC_003028.3 176877 179708 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 176877..179708 Streptococcus pneumoniae TIGR4 929980 NP_344728.1 CDS SP_0187 NC_003028.3 179701 180762 D identified by match to PFAM protein family HMM PF00557; peptidase M24 family protein 179701..180762 Streptococcus pneumoniae TIGR4 929981 NP_344729.1 CDS SP_0188 NC_003028.3 180767 180859 D hypothetical protein 180767..180859 Streptococcus pneumoniae TIGR4 929983 NP_344730.1 CDS spxA NC_003028.3 180894 181292 D the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 180894..181292 Streptococcus pneumoniae TIGR4 929984 NP_344731.1 CDS SP_0190 NC_003028.3 181261 181380 D hypothetical protein 181261..181380 Streptococcus pneumoniae TIGR4 929985 NP_344732.1 CDS SP_0191 NC_003028.3 181358 181927 D hypothetical protein 181358..181927 Streptococcus pneumoniae TIGR4 929986 NP_344733.1 CDS SP_0192 NC_003028.3 182014 182280 D hypothetical protein 182014..182280 Streptococcus pneumoniae TIGR4 929987 NP_344734.1 CDS SP_0194 NC_003028.3 182719 183024 D hypothetical protein 182719..183024 Streptococcus pneumoniae TIGR4 929989 NP_344735.1 CDS SP_0195 NC_003028.3 182990 183088 D hypothetical protein 182990..183088 Streptococcus pneumoniae TIGR4 929990 NP_344736.1 CDS SP_0196 NC_003028.3 183073 183168 D hypothetical protein 183073..183168 Streptococcus pneumoniae TIGR4 929991 NP_344737.1 CDS SP_0197 NC_003028.3 183283 184533 D dihydrofolate synthetase 183283..184533 Streptococcus pneumoniae TIGR4 929992 NP_344738.1 CDS SP_0198 NC_003028.3 184617 185075 D hypothetical protein 184617..185075 Streptococcus pneumoniae TIGR4 929993 NP_344739.1 CDS SP_0199 NC_003028.3 185329 186753 D cardiolipin synthetase 185329..186753 Streptococcus pneumoniae TIGR4 929994 NP_344740.1 CDS SP_0200 NC_003028.3 187011 188306 D similar to GB:Pyro_h; identified by sequence similarity; competence-induced protein Ccs4 187011..188306 Streptococcus pneumoniae TIGR4 929995 NP_344741.1 CDS SP_0201 NC_003028.3 188284 188550 D hypothetical protein 188284..188550 Streptococcus pneumoniae TIGR4 929996 NP_344742.1 CDS SP_0202 NC_003028.3 188670 190877 D Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 188670..190877 Streptococcus pneumoniae TIGR4 929997 NP_344743.1 CDS SP_0203 NC_003028.3 190889 191029 D hypothetical protein 190889..191029 Streptococcus pneumoniae TIGR4 929999 NP_344744.1 CDS SP_0204 NC_003028.3 191073 191579 D acetyltransferase 191073..191579 Streptococcus pneumoniae TIGR4 930000 NP_344745.1 CDS SP_0205 NC_003028.3 191572 192162 D identified by match to PFAM protein family HMM PF02143; anaerobic ribonucleoside-triphosphate reductase activating protein 191572..192162 Streptococcus pneumoniae TIGR4 930002 NP_344746.1 CDS SP_0206 NC_003028.3 192159 192461 D hypothetical protein 192159..192461 Streptococcus pneumoniae TIGR4 930003 NP_344747.1 CDS SP_0207 NC_003028.3 192437 192775 D similar to GP:7302796; identified by sequence similarity; hypothetical protein 192437..192775 Streptococcus pneumoniae TIGR4 930005 NP_344748.1 CDS rpsJ NC_003028.3 193042 193350 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 193042..193350 Streptococcus pneumoniae TIGR4 930006 NP_344749.1 CDS rplC NC_003028.3 193567 194193 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 193567..194193 Streptococcus pneumoniae TIGR4 930007 NP_344750.1 CDS rplD NC_003028.3 194218 194841 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 194218..194841 Streptococcus pneumoniae TIGR4 930009 NP_344751.1 CDS rplW NC_003028.3 194841 195137 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 194841..195137 Streptococcus pneumoniae TIGR4 930010 NP_344752.1 CDS rplB NC_003028.3 195155 195988 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 195155..195988 Streptococcus pneumoniae TIGR4 930011 NP_344753.1 CDS rpsS NC_003028.3 196092 196373 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 196092..196373 Streptococcus pneumoniae TIGR4 930012 NP_344754.1 CDS rplV NC_003028.3 196385 196729 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 196385..196729 Streptococcus pneumoniae TIGR4 930013 NP_344755.1 CDS rpsC NC_003028.3 196742 197395 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 196742..197395 Streptococcus pneumoniae TIGR4 930014 NP_344756.1 CDS rplP NC_003028.3 197399 197812 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 197399..197812 Streptococcus pneumoniae TIGR4 930015 NP_344757.1 CDS rpmC NC_003028.3 197822 198028 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 197822..198028 Streptococcus pneumoniae TIGR4 930016 NP_344758.1 CDS rpsQ NC_003028.3 198053 198313 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 198053..198313 Streptococcus pneumoniae TIGR4 930018 NP_344759.1 CDS rplN NC_003028.3 198339 198707 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 198339..198707 Streptococcus pneumoniae TIGR4 930019 NP_344760.1 CDS rplX NC_003028.3 198785 199090 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 198785..199090 Streptococcus pneumoniae TIGR4 930020 NP_344761.1 CDS rplE NC_003028.3 199114 199656 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 199114..199656 Streptococcus pneumoniae TIGR4 930021 NP_344762.1 CDS rpsN NC_003028.3 199674 199943 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 199674..199943 Streptococcus pneumoniae TIGR4 930022 NP_344763.1 CDS SP_0223 NC_003028.3 199910 200032 R hypothetical protein complement(199910..200032) Streptococcus pneumoniae TIGR4 930023 NP_344764.1 CDS rpsH NC_003028.3 200228 200626 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 200228..200626 Streptococcus pneumoniae TIGR4 930024 NP_344765.1 CDS rplF NC_003028.3 200818 201354 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 200818..201354 Streptococcus pneumoniae TIGR4 930025 NP_344766.1 CDS rplR NC_003028.3 201438 201794 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 201438..201794 Streptococcus pneumoniae TIGR4 930026 NP_344767.1 CDS rpsE NC_003028.3 201812 202306 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 201812..202306 Streptococcus pneumoniae TIGR4 930027 NP_344768.1 CDS rpmD NC_003028.3 202320 202502 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 202320..202502 Streptococcus pneumoniae TIGR4 930028 NP_344769.1 CDS rplO NC_003028.3 202647 203087 D late assembly protein; 50S ribosomal protein L15 202647..203087 Streptococcus pneumoniae TIGR4 930029 NP_344770.1 CDS secY NC_003028.3 203100 204410 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 203100..204410 Streptococcus pneumoniae TIGR4 930030 NP_344771.1 CDS adk NC_003028.3 204561 205199 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 204561..205199 Streptococcus pneumoniae TIGR4 930031 NP_344772.1 CDS infA NC_003028.3 205316 205534 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 205316..205534 Streptococcus pneumoniae TIGR4 930032 NP_344773.1 CDS rpmJ NC_003028.3 205559 205675 D smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 205559..205675 Streptococcus pneumoniae TIGR4 930033 NP_344774.1 CDS rpsM NC_003028.3 205693 206058 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 205693..206058 Streptococcus pneumoniae TIGR4 930034 NP_344775.1 CDS SP_0235 NC_003028.3 206076 206459 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 206076..206459 Streptococcus pneumoniae TIGR4 930035 NP_344776.1 CDS SP_0236 NC_003028.3 206502 207437 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 206502..207437 Streptococcus pneumoniae TIGR4 930036 NP_344777.1 CDS rplQ NC_003028.3 207449 207835 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 207449..207835 Streptococcus pneumoniae TIGR4 930037 NP_344778.1 CDS SP_0238 NC_003028.3 208100 208366 D ACT domain-containing protein; hypothetical protein 208100..208366 Streptococcus pneumoniae TIGR4 930038 NP_344779.1 CDS SP_0239 NC_003028.3 208376 209713 D hypothetical protein 208376..209713 Streptococcus pneumoniae TIGR4 930039 NP_344780.1 CDS SP_0240 NC_003028.3 209957 210649 D phosphoglycerate mutase 209957..210649 Streptococcus pneumoniae TIGR4 930040 NP_344781.1 CDS SP_0242 NC_003028.3 212387 213478 R ABC transporter ATP-binding protein complement(212387..213478) Streptococcus pneumoniae TIGR4 930043 NP_344782.1 CDS SP_0243 NC_003028.3 213491 214507 R iron ABC transporter substrate-binding protein complement(213491..214507) Streptococcus pneumoniae TIGR4 930044 NP_344783.1 CDS SP_0244 NC_003028.3 214812 214919 R hypothetical protein complement(214812..214919) Streptococcus pneumoniae TIGR4 930045 NP_344784.1 CDS SP_0245 NC_003028.3 215094 215870 R identified by match to PFAM protein family HMM PF02143; pyruvate formate-lyase-activating enzyme complement(215094..215870) Streptococcus pneumoniae TIGR4 930046 NP_344785.1 CDS SP_0246 NC_003028.3 215992 216738 D DeoR family transcriptional regulator 215992..216738 Streptococcus pneumoniae TIGR4 930048 NP_344786.1 CDS SP_0247 NC_003028.3 216751 217731 D similar to SP:P37078 GB:X66059 PID:43938; identified by sequence similarity; transcriptional regulator 216751..217731 Streptococcus pneumoniae TIGR4 930049 NP_344787.1 CDS SP_0248 NC_003028.3 217926 218246 D PTS system transporter subunit IIA 217926..218246 Streptococcus pneumoniae TIGR4 930050 NP_344788.1 CDS SP_0249 NC_003028.3 218292 218600 D PTS system transporter subunit IIB 218292..218600 Streptococcus pneumoniae TIGR4 930051 NP_344789.1 CDS SP_0250 NC_003028.3 218593 219915 D PTS system transporter subunit IIC 218593..219915 Streptococcus pneumoniae TIGR4 930052 NP_344790.1 CDS SP_0251 NC_003028.3 220066 222504 D identified by match to PFAM protein family HMM PF01228; formate acetyltransferase 220066..222504 Streptococcus pneumoniae TIGR4 930053 NP_344791.1 CDS SP_0252 NC_003028.3 222523 223191 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 222523..223191 Streptococcus pneumoniae TIGR4 930054 NP_344792.1 CDS gldA NC_003028.3 223209 224297 D forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 223209..224297 Streptococcus pneumoniae TIGR4 930055 NP_344793.1 CDS leuS NC_003028.3 224752 227253 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 224752..227253 Streptococcus pneumoniae TIGR4 930056 NP_344794.1 CDS SP_0255 NC_003028.3 227448 228143 D acetyltransferase 227448..228143 Streptococcus pneumoniae TIGR4 930057 NP_344795.1 CDS SP_0256 NC_003028.3 228155 228571 D acetyltransferase 228155..228571 Streptococcus pneumoniae TIGR4 930059 NP_344796.1 CDS SP_0258 NC_003028.3 231373 231465 R hypothetical protein complement(231373..231465) Streptococcus pneumoniae TIGR4 930061 NP_344797.1 CDS ruvB NC_003028.3 231600 232598 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 231600..232598 Streptococcus pneumoniae TIGR4 930063 NP_344798.1 CDS SP_0260 NC_003028.3 232579 233151 D hypothetical protein 232579..233151 Streptococcus pneumoniae TIGR4 930064 NP_344799.1 CDS SP_0261 NC_003028.3 233382 234140 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 233382..234140 Streptococcus pneumoniae TIGR4 930065 NP_344800.1 CDS SP_0262 NC_003028.3 234149 234952 D phosphatidate cytidylyltransferase 234149..234952 Streptococcus pneumoniae TIGR4 930067 NP_344801.1 CDS SP_0263 NC_003028.3 234974 236233 D identified by match to TIGR protein family HMM TIGR00054; eep protein 234974..236233 Streptococcus pneumoniae TIGR4 930069 NP_344802.1 CDS SP_0264 NC_003028.3 236246 238099 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 236246..238099 Streptococcus pneumoniae TIGR4 930070 NP_344803.1 CDS SP_0265 NC_003028.3 238198 239577 D glycosyl hydrolase 238198..239577 Streptococcus pneumoniae TIGR4 930071 NP_344804.1 CDS SP_0266 NC_003028.3 239770 241578 D Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 239770..241578 Streptococcus pneumoniae TIGR4 930072 NP_344805.1 CDS SP_0267 NC_003028.3 241697 242746 D similar to GP:2735505; identified by sequence similarity; hypothetical protein 241697..242746 Streptococcus pneumoniae TIGR4 930074 NP_344806.1 CDS SP_0268 NC_003028.3 242846 246688 R identified by match to PFAM protein family HMM PF00746; alkaline amylopullulanase complement(242846..246688) Streptococcus pneumoniae TIGR4 930075 NP_344807.1 CDS SP_0269 NC_003028.3 246875 246970 D hypothetical protein 246875..246970 Streptococcus pneumoniae TIGR4 930076 NP_344808.1 CDS SP_0270 NC_003028.3 247026 247118 D hypothetical protein 247026..247118 Streptococcus pneumoniae TIGR4 930078 NP_344809.1 CDS rpsL NC_003028.3 247105 247518 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 247105..247518 Streptococcus pneumoniae TIGR4 930079 NP_344810.1 CDS SP_0272 NC_003028.3 247538 248008 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 247538..248008 Streptococcus pneumoniae TIGR4 930080 NP_344811.1 CDS SP_0273 NC_003028.3 248433 250514 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 248433..250514 Streptococcus pneumoniae TIGR4 930081 NP_344812.1 CDS polC NC_003028.3 250618 255009 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 250618..255009 Streptococcus pneumoniae TIGR4 930082 NP_344813.1 CDS SP_0275 NC_003028.3 255111 255374 D hypothetical protein 255111..255374 Streptococcus pneumoniae TIGR4 930083 NP_344814.1 CDS SP_0276 NC_003028.3 255367 255645 D hypothetical protein 255367..255645 Streptococcus pneumoniae TIGR4 930084 NP_344815.1 CDS SP_0277 NC_003028.3 255666 255818 D hypothetical protein 255666..255818 Streptococcus pneumoniae TIGR4 930086 NP_344816.1 CDS SP_0278 NC_003028.3 255840 257081 D identified by match to PFAM protein family HMM PF02073; aminopeptidase 255840..257081 Streptococcus pneumoniae TIGR4 930087 NP_344817.1 CDS SP_0279 NC_003028.3 257091 257321 D hypothetical protein 257091..257321 Streptococcus pneumoniae TIGR4 930088 NP_344818.1 CDS SP_0280 NC_003028.3 257589 258311 D ribosomal small subunit pseudouridine synthase A 257589..258311 Streptococcus pneumoniae TIGR4 930089 NP_344819.1 CDS SP_0281 NC_003028.3 258529 259863 D similar to GB:Z30315 PID:535273; identified by sequence similarity; aminopeptidase 258529..259863 Streptococcus pneumoniae TIGR4 930090 NP_344820.1 CDS SP_0282 NC_003028.3 259919 260830 R PTS system mannose-specific transporter subunit IID complement(259919..260830) Streptococcus pneumoniae TIGR4 930091 NP_344821.1 CDS SP_0283 NC_003028.3 260854 261657 R PTS system mannose-specific transporter subunit IIC complement(260854..261657) Streptococcus pneumoniae TIGR4 930092 NP_344822.1 CDS SP_0284 NC_003028.3 261685 262683 R PTS system mannose-specific transporter subunit IIAB complement(261685..262683) Streptococcus pneumoniae TIGR4 930093 NP_344823.1 CDS SP_0285 NC_003028.3 262907 263926 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(262907..263926) Streptococcus pneumoniae TIGR4 930095 NP_344824.1 CDS SP_0286 NC_003028.3 264266 265078 R Cof family protein complement(264266..265078) Streptococcus pneumoniae TIGR4 930097 NP_344825.1 CDS SP_0287 NC_003028.3 265214 266686 D xanthine/uracil permease 265214..266686 Streptococcus pneumoniae TIGR4 930098 NP_344826.1 CDS SP_0288 NC_003028.3 266754 267446 D hypothetical protein 266754..267446 Streptococcus pneumoniae TIGR4 930099 NP_344827.1 CDS SP_0289 NC_003028.3 267571 268515 D identified by match to PFAM protein family HMM PF00809; dihydropteroate synthase 267571..268515 Streptococcus pneumoniae TIGR4 930100 NP_344828.1 CDS SP_0290 NC_003028.3 268517 269839 D dihydrofolate synthetase 268517..269839 Streptococcus pneumoniae TIGR4 930101 NP_344829.1 CDS folE NC_003028.3 269820 270374 D involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 269820..270374 Streptococcus pneumoniae TIGR4 930102 NP_344830.1 CDS SP_0292 NC_003028.3 270417 271229 D identified by match to PFAM protein family HMM PF01288; bifunctional folate synthesis protein 270417..271229 Streptococcus pneumoniae TIGR4 930103 NP_344831.1 CDS SP_0293 NC_003028.3 271379 271750 R hypothetical protein complement(271379..271750) Streptococcus pneumoniae TIGR4 930105 NP_344832.1 CDS rplM NC_003028.3 272052 272498 D in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 272052..272498 Streptococcus pneumoniae TIGR4 930106 NP_344833.1 CDS rpsI NC_003028.3 272517 272909 D forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 272517..272909 Streptococcus pneumoniae TIGR4 930107 NP_344834.1 CDS SP_0296 NC_003028.3 273172 273303 R hypothetical protein complement(273172..273303) Streptococcus pneumoniae TIGR4 930108 NP_344835.1 CDS SP_0297 NC_003028.3 273502 273651 R hypothetical protein complement(273502..273651) Streptococcus pneumoniae TIGR4 930109 NP_344836.1 CDS SP_0298 NC_003028.3 273953 275161 R hypothetical protein complement(273953..275161) Streptococcus pneumoniae TIGR4 930110 NP_344837.1 CDS SP_0299 NC_003028.3 275290 275637 D IS630-Spn1, transposase Orf1, authentic frameshift 275290..275637 Streptococcus pneumoniae TIGR4 930111 NP_344838.1 CDS SP_0300 NC_003028.3 275816 276154 D IS630-Spn1, transposase Orf2 275816..276154 Streptococcus pneumoniae TIGR4 930112 NP_344839.1 CDS SP_0302 NC_003028.3 276283 276648 D similar to GP:9658050; identified by sequence similarity; hypothetical protein 276283..276648 Streptococcus pneumoniae TIGR4 930115 NP_344840.1 CDS celA NC_003028.3 276838 278274 D converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 276838..278274 Streptococcus pneumoniae TIGR4 930116 NP_344841.1 CDS SP_0304 NC_003028.3 278326 278565 D hypothetical protein 278326..278565 Streptococcus pneumoniae TIGR4 930117 NP_344842.1 CDS celB NC_003028.3 278695 279009 D required for cellobiose uptake and metabolism; PTS system cellobiose transporter subunit IIB 278695..279009 Streptococcus pneumoniae TIGR4 930118 NP_344843.1 CDS SP_0306 NC_003028.3 279127 280608 D transcriptional regulator 279127..280608 Streptococcus pneumoniae TIGR4 930119 NP_344844.1 CDS SP_0307 NC_003028.3 280609 281106 D PTS system transporter subunit IIA 280609..281106 Streptococcus pneumoniae TIGR4 930120 NP_344845.1 CDS celC NC_003028.3 281116 281430 D required for cellobiose uptake and metabolism; cellobiose phosphotransferase system IIA component 281116..281430 Streptococcus pneumoniae TIGR4 930121 NP_344846.1 CDS SP_0309 NC_003028.3 281461 281967 D hypothetical protein 281461..281967 Streptococcus pneumoniae TIGR4 930122 NP_344847.1 CDS celD NC_003028.3 282047 283393 D required for cellobiose uptake and metabolism; cellobiose phosphotransferase system IIC component 282047..283393 Streptococcus pneumoniae TIGR4 930123 NP_344848.1 CDS SP_0311 NC_003028.3 283772 283948 D hypothetical protein 283772..283948 Streptococcus pneumoniae TIGR4 930124 NP_344849.1 CDS SP_0312 NC_003028.3 284523 286562 D identified by match to PFAM protein family HMM PF01055; glycosyl hydrolase 284523..286562 Streptococcus pneumoniae TIGR4 930125 NP_344850.1 CDS SP_0313 NC_003028.3 286784 287260 R identified by match to PFAM protein family HMM PF00255; glutathione peroxidase complement(286784..287260) Streptococcus pneumoniae TIGR4 930126 NP_344851.1 CDS SP_0314 NC_003028.3 287483 290683 D identified by match to PFAM protein family HMM PF02278; hyaluronidase 287483..290683 Streptococcus pneumoniae TIGR4 930127 NP_344852.1 CDS SP_0316 NC_003028.3 291700 291807 R hypothetical protein complement(291700..291807) Streptococcus pneumoniae TIGR4 930129 NP_344853.1 CDS SP_0317 NC_003028.3 291831 292460 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(291831..292460) Streptococcus pneumoniae TIGR4 930130 NP_344854.1 CDS SP_0318 NC_003028.3 292470 293471 R carbohydrate kinase complement(292470..293471) Streptococcus pneumoniae TIGR4 930131 NP_344855.1 CDS SP_0319 NC_003028.3 293502 294143 R hypothetical protein complement(293502..294143) Streptococcus pneumoniae TIGR4 930132 NP_344856.1 CDS SP_0320 NC_003028.3 294162 294977 R Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase complement(294162..294977) Streptococcus pneumoniae TIGR4 930133 NP_344857.1 CDS SP_0321 NC_003028.3 295248 295682 D PTS system transporter subunit IIA 295248..295682 Streptococcus pneumoniae TIGR4 930134 NP_344858.1 CDS SP_0322 NC_003028.3 295694 296884 D similar to GP:5869507; identified by sequence similarity; glucuronyl hydrolase 295694..296884 Streptococcus pneumoniae TIGR4 930136 NP_344859.1 CDS SP_0323 NC_003028.3 296895 297386 D PTS system transporter subunit IIB 296895..297386 Streptococcus pneumoniae TIGR4 930137 NP_344860.1 CDS SP_0324 NC_003028.3 297401 298180 D PTS system transporter subunit IIC 297401..298180 Streptococcus pneumoniae TIGR4 930138 NP_344861.1 CDS SP_0325 NC_003028.3 298167 298985 D PTS system transporter subunit IID 298167..298985 Streptococcus pneumoniae TIGR4 930139 NP_344862.1 CDS SP_0326 NC_003028.3 298985 299278 D identified by match to TIGR protein family HMM TIGR00739; preprotein translocase subunit YajC 298985..299278 Streptococcus pneumoniae TIGR4 930141 NP_344863.1 CDS SP_0327 NC_003028.3 299300 300940 D hypothetical protein 299300..300940 Streptococcus pneumoniae TIGR4 930142 NP_344864.1 CDS SP_0328 NC_003028.3 301056 302402 D similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 301056..302402 Streptococcus pneumoniae TIGR4 930143 NP_344865.1 CDS SP_0329 NC_003028.3 302580 302909 D hypothetical protein 302580..302909 Streptococcus pneumoniae TIGR4 930144 NP_344866.1 CDS SP_0330 NC_003028.3 302969 303970 D sugar binding transcriptional regulator RegR 302969..303970 Streptococcus pneumoniae TIGR4 930145 NP_344867.1 CDS SP_0332 NC_003028.3 304679 305221 R hypothetical protein complement(304679..305221) Streptococcus pneumoniae TIGR4 930147 NP_344868.1 CDS SP_0333 NC_003028.3 305237 305431 R transcriptional regulator complement(305237..305431) Streptococcus pneumoniae TIGR4 930150 NP_344869.1 CDS mraW NC_003028.3 305597 306547 D S-adenosyl-methyltransferase MraW 305597..306547 Streptococcus pneumoniae TIGR4 930151 NP_344870.1 CDS SP_0335 NC_003028.3 306559 306876 D similar to GP:1524351; identified by sequence similarity; cell division protein FtsL 306559..306876 Streptococcus pneumoniae TIGR4 930152 NP_344871.1 CDS SP_0336 NC_003028.3 306880 309132 D penicillin-binding protein 2X 306880..309132 Streptococcus pneumoniae TIGR4 930153 NP_344872.1 CDS mraY NC_003028.3 309134 310114 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 309134..310114 Streptococcus pneumoniae TIGR4 930154 NP_344873.1 CDS SP_0338 NC_003028.3 310723 312828 D ATP-dependent Clp protease ATP-binding subunit 310723..312828 Streptococcus pneumoniae TIGR4 930156 NP_344874.1 CDS SP_0340 NC_003028.3 313124 313606 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(313124..313606) Streptococcus pneumoniae TIGR4 930158 NP_344875.1 CDS SP_0341 NC_003028.3 313701 315185 R hypothetical protein complement(313701..315185) Streptococcus pneumoniae TIGR4 930159 NP_344876.1 CDS SP_0342 NC_003028.3 315338 316945 D glucan 1,6-alpha-glucosidase 315338..316945 Streptococcus pneumoniae TIGR4 930160 NP_344877.1 CDS SP_0343 NC_003028.3 317355 318701 R similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase complement(317355..318701) Streptococcus pneumoniae TIGR4 930161 NP_344878.1 CDS SP_0344 NC_003028.3 318978 319316 R IS630-Spn1, transposase Orf2 complement(318978..319316) Streptococcus pneumoniae TIGR4 930162 YP_873925.1 CDS SP_0345 NC_003028.3 319495 319842 R Orf1; IS630-Spn1 transposase complement(319495..319842) Streptococcus pneumoniae TIGR4 930163 NP_344879.1 CDS SP_0346 NC_003028.3 320077 321522 D capsular polysaccharide biosynthesis protein Cps4A 320077..321522 Streptococcus pneumoniae TIGR4 930165 NP_344880.1 CDS SP_0347 NC_003028.3 321524 322255 D similar to GP:3550628; identified by sequence similarity; capsular polysaccharide biosynthesis protein Cps4B 321524..322255 Streptococcus pneumoniae TIGR4 930166 NP_344881.1 CDS SP_0348 NC_003028.3 322264 322956 D capsular polysaccharide biosynthesis protein Cps4C 322264..322956 Streptococcus pneumoniae TIGR4 930167 NP_344882.1 CDS SP_0349 NC_003028.3 322966 323649 D capsular polysaccharide biosynthesis protein Cps4D 322966..323649 Streptococcus pneumoniae TIGR4 930168 NP_344883.1 CDS SP_0350 NC_003028.3 323990 324625 D identified by match to PFAM protein family HMM PF02397; capsular polysaccharide biosynthesis protein Cps4E 323990..324625 Streptococcus pneumoniae TIGR4 930169 NP_344884.1 CDS SP_0351 NC_003028.3 324634 325863 D capsular polysaccharide biosynthesis protein Cps4F 324634..325863 Streptococcus pneumoniae TIGR4 930170 NP_344885.1 CDS SP_0352 NC_003028.3 325868 326944 D similar to GP:1657647; identified by sequence similarity; capsular polysaccharide biosynthesis protein Cps4G 325868..326944 Streptococcus pneumoniae TIGR4 930171 NP_344886.1 CDS SP_0353 NC_003028.3 326937 328055 D capsular polysaccharide biosynthesis protein Cps4H 326937..328055 Streptococcus pneumoniae TIGR4 930172 NP_344887.1 CDS SP_0354 NC_003028.3 328056 329456 D hypothetical protein 328056..329456 Streptococcus pneumoniae TIGR4 930173 NP_344888.1 CDS SP_0355 NC_003028.3 329456 330538 D hypothetical protein 329456..330538 Streptococcus pneumoniae TIGR4 930174 NP_344889.1 CDS SP_0356 NC_003028.3 330528 331769 D polysaccharide transporter 330528..331769 Streptococcus pneumoniae TIGR4 930175 NP_344890.1 CDS SP_0357 NC_003028.3 331774 332871 D identified by match to PFAM protein family HMM PF02350; UDP-N-acetylglucosamine-2-epimerase 331774..332871 Streptococcus pneumoniae TIGR4 930176 NP_344891.1 CDS SP_0358 NC_003028.3 332875 333930 D capsular polysaccharide biosynthesis protein Cps4J 332875..333930 Streptococcus pneumoniae TIGR4 930177 NP_344892.1 CDS SP_0359 NC_003028.3 334030 335259 D capsular polysaccharide biosynthesis protein Cps4K 334030..335259 Streptococcus pneumoniae TIGR4 930178 NP_344893.1 CDS SP_0360 NC_003028.3 335260 336444 D identified by match to TIGR protein family HMM TIGR00236; UDP-N-acetylglucosamine 2-epimerase 335260..336444 Streptococcus pneumoniae TIGR4 930186 NP_344894.1 CDS SP_0366 NC_003028.3 339096 341081 D oligopeptide ABC transporter oligopeptide-binding protein AliA 339096..341081 Streptococcus pneumoniae TIGR4 930256 NP_344895.1 CDS SP_0367 NC_003028.3 341229 341348 D hypothetical protein 341229..341348 Streptococcus pneumoniae TIGR4 930260 YP_873926.1 CDS SP_0368 NC_003028.3 341383 346686 D cell wall surface anchor family protein 341383..346686 Streptococcus pneumoniae TIGR4 930268 NP_344896.1 CDS SP_0369 NC_003028.3 346853 349012 R penicillin-binding protein 1A complement(346853..349012) Streptococcus pneumoniae TIGR4 930269 NP_344897.1 CDS recU NC_003028.3 349009 349605 R functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease complement(349009..349605) Streptococcus pneumoniae TIGR4 930277 NP_344898.1 CDS SP_0371 NC_003028.3 349671 350198 D hypothetical protein 349671..350198 Streptococcus pneumoniae TIGR4 930279 NP_344899.1 CDS SP_0372 NC_003028.3 350268 350597 D hypothetical protein 350268..350597 Streptococcus pneumoniae TIGR4 930282 NP_344900.1 CDS SP_0373 NC_003028.3 351083 352240 D hypothetical protein 351083..352240 Streptococcus pneumoniae TIGR4 930284 NP_344901.1 CDS SP_0374 NC_003028.3 352253 353647 D hypothetical protein 352253..353647 Streptococcus pneumoniae TIGR4 930285 NP_344902.1 CDS SP_0375 NC_003028.3 353723 355147 D catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 353723..355147 Streptococcus pneumoniae TIGR4 930286 NP_344903.1 CDS SP_0376 NC_003028.3 355159 355848 D DNA-binding response regulator 355159..355848 Streptococcus pneumoniae TIGR4 930289 NP_344904.1 CDS SP_0377 NC_003028.3 355947 356969 D choline binding protein C 355947..356969 Streptococcus pneumoniae TIGR4 930291 NP_344905.1 CDS SP_0378 NC_003028.3 356987 357985 D choline binding protein J 356987..357985 Streptococcus pneumoniae TIGR4 930292 NP_344906.1 CDS SP_0379 NC_003028.3 358103 359335 R hypothetical protein complement(358103..359335) Streptococcus pneumoniae TIGR4 930294 NP_344907.1 CDS SP_0380 NC_003028.3 359378 360253 R hypothetical protein complement(359378..360253) Streptococcus pneumoniae TIGR4 930295 NP_344908.1 CDS SP_0381 NC_003028.3 361318 362196 D mevalonate kinase 361318..362196 Streptococcus pneumoniae TIGR4 930296 NP_344909.1 CDS SP_0382 NC_003028.3 362178 363131 D identified by match to TIGR protein family HMM TIGR01240; diphosphomevalonate decarboxylase 362178..363131 Streptococcus pneumoniae TIGR4 930298 NP_344910.1 CDS SP_0383 NC_003028.3 363118 364125 D identified by match to TIGR protein family HMM TIGR01220; phosphomevalonate kinase 363118..364125 Streptococcus pneumoniae TIGR4 930299 NP_344911.1 CDS SP_0384 NC_003028.3 364109 365119 D catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 364109..365119 Streptococcus pneumoniae TIGR4 930300 NP_344912.1 CDS SP_0385 NC_003028.3 365196 365894 D hypothetical protein 365196..365894 Streptococcus pneumoniae TIGR4 930301 NP_344913.1 CDS SP_0386 NC_003028.3 365891 366886 D sensor histidine kinase 365891..366886 Streptococcus pneumoniae TIGR4 930303 NP_344914.1 CDS SP_0387 NC_003028.3 366900 367532 D DNA-binding response regulator 366900..367532 Streptococcus pneumoniae TIGR4 930305 NP_344915.1 CDS SP_0389 NC_003028.3 368451 368690 D hypothetical protein 368451..368690 Streptococcus pneumoniae TIGR4 930308 NP_344916.1 CDS SP_0390 NC_003028.3 368735 369592 D choline binding protein G 368735..369592 Streptococcus pneumoniae TIGR4 930309 NP_344917.1 CDS SP_0391 NC_003028.3 369611 370633 D choline binding protein F 369611..370633 Streptococcus pneumoniae TIGR4 930315 NP_344918.1 CDS SP_0394 NC_003028.3 372310 374079 D PTS system mannitol-specific transporter subunit IIBC 372310..374079 Streptococcus pneumoniae TIGR4 930325 NP_344919.1 CDS SP_0395 NC_003028.3 374103 376058 D transcriptional regulator 374103..376058 Streptococcus pneumoniae TIGR4 930326 NP_344920.1 CDS SP_0396 NC_003028.3 376060 376497 D PTS system mannitol-specific transporter subunit IIA 376060..376497 Streptococcus pneumoniae TIGR4 930330 NP_344921.1 CDS SP_0397 NC_003028.3 376559 377695 D identified by match to PFAM protein family HMM PF01232; mannitol-1-phosphate 5-dehydrogenase 376559..377695 Streptococcus pneumoniae TIGR4 930331 NP_344922.1 CDS SP_0398 NC_003028.3 377853 378011 D hypothetical protein 377853..378011 Streptococcus pneumoniae TIGR4 930332 NP_344923.1 CDS tig NC_003028.3 378481 379764 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 378481..379764 Streptococcus pneumoniae TIGR4 930334 NP_344924.1 CDS SP_0401 NC_003028.3 379812 382178 R identified by match to PFAM protein family HMM PF01443; helicase complement(379812..382178) Streptococcus pneumoniae TIGR4 930335 NP_344925.1 CDS SP_0402 NC_003028.3 382457 383071 R signal peptidase I complement(382457..383071) Streptococcus pneumoniae TIGR4 930336 NP_344926.1 CDS SP_0403 NC_003028.3 383075 383956 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII complement(383075..383956) Streptococcus pneumoniae TIGR4 930337 NP_344927.1 CDS SP_0404 NC_003028.3 384034 384345 D hypothetical protein 384034..384345 Streptococcus pneumoniae TIGR4 930340 NP_344928.1 CDS SP_0405 NC_003028.3 384342 384890 D hypothetical protein 384342..384890 Streptococcus pneumoniae TIGR4 930341 NP_344929.1 CDS SP_0406 NC_003028.3 384994 387330 D MutS2 family protein 384994..387330 Streptococcus pneumoniae TIGR4 930342 NP_344930.1 CDS SP_0407 NC_003028.3 387451 387552 R hypothetical protein complement(387451..387552) Streptococcus pneumoniae TIGR4 930343 NP_344931.1 CDS SP_0408 NC_003028.3 387673 388995 D identified by match to PFAM protein family HMM PF01235; sodium:alanine symporter family protein 387673..388995 Streptococcus pneumoniae TIGR4 930344 NP_344932.1 CDS SP_0409 NC_003028.3 389213 389761 D hypothetical protein 389213..389761 Streptococcus pneumoniae TIGR4 930345 NP_344933.1 CDS SP_0410 NC_003028.3 389871 390770 D exfoliative toxin 389871..390770 Streptococcus pneumoniae TIGR4 930346 NP_344934.1 CDS SP_0411 NC_003028.3 390795 392069 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(390795..392069) Streptococcus pneumoniae TIGR4 930347 NP_344935.1 CDS SP_0412 NC_003028.3 392282 392653 R hypothetical protein complement(392282..392653) Streptococcus pneumoniae TIGR4 930348 NP_344936.1 CDS SP_0413 NC_003028.3 392656 394020 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase complement(392656..394020) Streptococcus pneumoniae TIGR4 930349 NP_344937.1 CDS SP_0414 NC_003028.3 394104 394208 R hypothetical protein complement(394104..394208) Streptococcus pneumoniae TIGR4 930350 NP_344938.1 CDS SP_0415 NC_003028.3 394345 395130 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 394345..395130 Streptococcus pneumoniae TIGR4 930351 NP_344939.1 CDS SP_0416 NC_003028.3 395224 395658 D MarR family transcriptional regulator 395224..395658 Streptococcus pneumoniae TIGR4 930352 NP_344940.1 CDS SP_0417 NC_003028.3 395658 396632 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 395658..396632 Streptococcus pneumoniae TIGR4 930353 NP_344941.1 CDS acpP NC_003028.3 396692 396916 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 396692..396916 Streptococcus pneumoniae TIGR4 930354 NP_344942.1 CDS SP_0419 NC_003028.3 397035 398009 D enoyl-ACP reductase 397035..398009 Streptococcus pneumoniae TIGR4 930355 NP_344943.1 CDS SP_0420 NC_003028.3 398002 398922 D identified by match to TIGR protein family HMM TIGR00128; ACP S-malonyltransferase 398002..398922 Streptococcus pneumoniae TIGR4 930356 NP_344944.1 CDS fabG NC_003028.3 398956 399687 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 398956..399687 Streptococcus pneumoniae TIGR4 930357 NP_344945.1 CDS SP_0422 NC_003028.3 399709 400944 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 399709..400944 Streptococcus pneumoniae TIGR4 930358 NP_344946.1 CDS SP_0423 NC_003028.3 400947 401432 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 400947..401432 Streptococcus pneumoniae TIGR4 930359 NP_344947.1 CDS fabZ NC_003028.3 401429 401851 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 401429..401851 Streptococcus pneumoniae TIGR4 930360 NP_344948.1 CDS SP_0425 NC_003028.3 401863 403230 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 401863..403230 Streptococcus pneumoniae TIGR4 930361 NP_344949.1 CDS SP_0426 NC_003028.3 403267 404133 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 403267..404133 Streptococcus pneumoniae TIGR4 930362 NP_344950.1 CDS SP_0427 NC_003028.3 404130 404897 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha 404130..404897 Streptococcus pneumoniae TIGR4 930363 NP_344951.1 CDS SP_0428 NC_003028.3 404908 405015 D hypothetical protein 404908..405015 Streptococcus pneumoniae TIGR4 930364 NP_344952.1 CDS SP_0429 NC_003028.3 405056 405241 D hypothetical protein 405056..405241 Streptococcus pneumoniae TIGR4 930365 NP_344953.1 CDS SP_0430 NC_003028.3 405214 405732 D hypothetical protein 405214..405732 Streptococcus pneumoniae TIGR4 930366 NP_344954.1 CDS SP_0431 NC_003028.3 405745 405981 D similar to GB:AL009126; identified by sequence similarity; hypothetical protein 405745..405981 Streptococcus pneumoniae TIGR4 930367 NP_344955.1 CDS nusB NC_003028.3 407504 407926 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(407504..407926) Streptococcus pneumoniae TIGR4 930369 NP_344956.1 CDS SP_0434 NC_003028.3 407919 408308 R hypothetical protein complement(407919..408308) Streptococcus pneumoniae TIGR4 930370 NP_344957.1 CDS SP_0435 NC_003028.3 408330 408890 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(408330..408890) Streptococcus pneumoniae TIGR4 930371 NP_344958.1 CDS gatB NC_003028.3 409019 410461 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(409019..410461) Streptococcus pneumoniae TIGR4 930372 NP_344959.1 CDS gatA NC_003028.3 410461 411927 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(410461..411927) Streptococcus pneumoniae TIGR4 930373 NP_344960.1 CDS gatC NC_003028.3 411927 412229 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(411927..412229) Streptococcus pneumoniae TIGR4 930375 NP_344961.1 CDS prfC NC_003028.3 412442 413986 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 412442..413986 Streptococcus pneumoniae TIGR4 930376 NP_344962.1 CDS rpmB NC_003028.3 414869 415057 D required for 70S ribosome assembly; 50S ribosomal protein L28 414869..415057 Streptococcus pneumoniae TIGR4 930378 NP_344963.1 CDS SP_0442 NC_003028.3 415214 415579 D hypothetical protein 415214..415579 Streptococcus pneumoniae TIGR4 930379 NP_344964.1 CDS SP_0443 NC_003028.3 415582 417249 D hypothetical protein 415582..417249 Streptococcus pneumoniae TIGR4 930380 NP_344965.1 CDS SP_0444 NC_003028.3 417236 417337 R hypothetical protein complement(417236..417337) Streptococcus pneumoniae TIGR4 930382 NP_344966.1 CDS SP_0445 NC_003028.3 417449 419149 D catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit 417449..419149 Streptococcus pneumoniae TIGR4 930383 NP_344967.1 CDS ilvH NC_003028.3 419142 419618 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 419142..419618 Streptococcus pneumoniae TIGR4 930384 NP_344968.1 CDS SP_0447 NC_003028.3 419696 420706 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 419696..420706 Streptococcus pneumoniae TIGR4 930385 NP_344969.1 CDS SP_0448 NC_003028.3 420783 421049 D hypothetical protein 420783..421049 Streptococcus pneumoniae TIGR4 930386 NP_344970.1 CDS SP_0449 NC_003028.3 421287 421643 D hypothetical protein 421287..421643 Streptococcus pneumoniae TIGR4 930387 NP_344971.1 CDS SP_0450 NC_003028.3 421693 422943 D catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 421693..422943 Streptococcus pneumoniae TIGR4 930388 NP_344972.1 CDS SP_0451 NC_003028.3 423678 423893 D hypothetical protein 423678..423893 Streptococcus pneumoniae TIGR4 930389 NP_344973.1 CDS SP_0452 NC_003028.3 424002 424742 R amino acid ABC transporter ATP-binding protein complement(424002..424742) Streptococcus pneumoniae TIGR4 930390 NP_344974.1 CDS SP_0453 NC_003028.3 424742 426307 R amino acid ABC transporter amino acid-binding protein/permease complement(424742..426307) Streptococcus pneumoniae TIGR4 930391 NP_344975.1 CDS SP_0454 NC_003028.3 426442 428334 D hypothetical protein 426442..428334 Streptococcus pneumoniae TIGR4 930392 NP_344976.1 CDS SP_0455 NC_003028.3 428331 428501 R hypothetical protein complement(428331..428501) Streptococcus pneumoniae TIGR4 930393 NP_344977.1 CDS uppP NC_003028.3 429907 430752 D BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 429907..430752 Streptococcus pneumoniae TIGR4 930395 NP_344978.1 CDS SP_0458 NC_003028.3 430899 431933 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(430899..431933) Streptococcus pneumoniae TIGR4 930396 NP_344979.1 CDS SP_0459 NC_003028.3 432308 434632 D identified by match to PFAM protein family HMM PF01228; formate acetyltransferase 432308..434632 Streptococcus pneumoniae TIGR4 930397 NP_344980.1 CDS SP_0460 NC_003028.3 434770 436038 R IS1167, transposase complement(434770..436038) Streptococcus pneumoniae TIGR4 930398 NP_344981.1 CDS SP_0461 NC_003028.3 436303 437832 R similar to GP:1289510; identified by sequence similarity; transcriptional regulator complement(436303..437832) Streptococcus pneumoniae TIGR4 930399 NP_344982.1 CDS SP_0462 NC_003028.3 438327 441008 D cell wall surface anchor family protein 438327..441008 Streptococcus pneumoniae TIGR4 930400 NP_344983.1 CDS SP_0463 NC_003028.3 441232 443229 D identified by match to PFAM protein family HMM PF00746; cell wall surface anchor family protein 441232..443229 Streptococcus pneumoniae TIGR4 930401 NP_344984.1 CDS SP_0464 NC_003028.3 443276 444457 D similar to PID:666069; identified by sequence similarity; cell wall surface anchor family protein 443276..444457 Streptococcus pneumoniae TIGR4 930402 NP_344985.1 CDS SP_0465 NC_003028.3 444676 444807 R hypothetical protein complement(444676..444807) Streptococcus pneumoniae TIGR4 930403 NP_344986.1 CDS SP_0466 NC_003028.3 444858 445697 D similar to GP:3036999; identified by sequence similarity; sortase 444858..445697 Streptococcus pneumoniae TIGR4 930404 NP_344987.1 CDS SP_0467 NC_003028.3 445792 446577 D similar to GP:3036999; identified by sequence similarity; sortase 445792..446577 Streptococcus pneumoniae TIGR4 930405 NP_344988.1 CDS SP_0468 NC_003028.3 446564 447415 D similar to GP:3036999; identified by sequence similarity; sortase 446564..447415 Streptococcus pneumoniae TIGR4 930406 NP_344989.1 CDS SP_0470 NC_003028.3 448879 449028 R hypothetical protein complement(448879..449028) Streptococcus pneumoniae TIGR4 930408 NP_344990.1 CDS SP_0471 NC_003028.3 449021 449305 R hypothetical protein complement(449021..449305) Streptococcus pneumoniae TIGR4 930409 NP_344991.1 CDS SP_0472 NC_003028.3 449697 449870 D hypothetical protein 449697..449870 Streptococcus pneumoniae TIGR4 930410 NP_344992.1 CDS SP_0473 NC_003028.3 450739 451962 R ROK family protein complement(450739..451962) Streptococcus pneumoniae TIGR4 930411 NP_344993.1 CDS SP_0474 NC_003028.3 452130 453452 D identified by match to PFAM protein family HMM PF02378; PTS system cellobiose-specific transporter subunit IIC 452130..453452 Streptococcus pneumoniae TIGR4 930412 NP_344994.1 CDS SP_0475 NC_003028.3 453400 455340 D hypothetical protein 453400..455340 Streptococcus pneumoniae TIGR4 930413 NP_344995.1 CDS SP_0476 NC_003028.3 455508 455852 D PTS system lactose-specific transporter subunit IIA 455508..455852 Streptococcus pneumoniae TIGR4 930414 NP_344996.1 CDS SP_0477 NC_003028.3 455862 457274 D catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 455862..457274 Streptococcus pneumoniae TIGR4 930415 NP_344997.1 CDS SP_0478 NC_003028.3 457343 459022 D PTS system lactose-specific transporter subunit IIBC 457343..459022 Streptococcus pneumoniae TIGR4 930416 NP_344998.1 CDS SP_0479 NC_003028.3 459148 460587 R Trk family potassium uptake protein complement(459148..460587) Streptococcus pneumoniae TIGR4 930417 NP_344999.1 CDS trkA NC_003028.3 460591 461940 R involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein complement(460591..461940) Streptococcus pneumoniae TIGR4 930418 NP_345000.1 CDS SP_0481 NC_003028.3 462101 462976 D hypothetical protein 462101..462976 Streptococcus pneumoniae TIGR4 930419 NP_345001.1 CDS SP_0482 NC_003028.3 462991 463539 D hypothetical protein 462991..463539 Streptococcus pneumoniae TIGR4 930420 NP_345002.1 CDS SP_0483 NC_003028.3 463905 465587 D ABC transporter ATP-binding protein 463905..465587 Streptococcus pneumoniae TIGR4 930421 NP_345003.1 CDS SP_0484 NC_003028.3 465572 466402 D hypothetical protein 465572..466402 Streptococcus pneumoniae TIGR4 930422 NP_345004.1 CDS SP_0486 NC_003028.3 466595 467098 D RNA methyltransferase 466595..467098 Streptococcus pneumoniae TIGR4 930423 NP_345005.1 CDS SP_0487 NC_003028.3 467295 467513 R hypothetical protein complement(467295..467513) Streptococcus pneumoniae TIGR4 930424 NP_345006.1 CDS SP_0488 NC_003028.3 467551 468114 D hypothetical protein 467551..468114 Streptococcus pneumoniae TIGR4 930425 NP_345007.1 CDS SP_0489 NC_003028.3 468104 468754 D identified by match to PFAM protein family HMM PF01569; PAP2 family protein 468104..468754 Streptococcus pneumoniae TIGR4 930426 NP_345008.1 CDS SP_0490 NC_003028.3 468782 469171 D hypothetical protein 468782..469171 Streptococcus pneumoniae TIGR4 930427 NP_345009.1 CDS SP_0491 NC_003028.3 469176 469331 D hypothetical protein 469176..469331 Streptococcus pneumoniae TIGR4 930428 NP_345010.1 CDS SP_0492 NC_003028.3 469303 469626 D hypothetical protein 469303..469626 Streptococcus pneumoniae TIGR4 930429 NP_345011.3 CDS SP_0493 NC_003028.3 469739 470341 D participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 469739..470341 Streptococcus pneumoniae TIGR4 930431 NP_345012.1 CDS pyrG NC_003028.3 470731 472338 D CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 470731..472338 Streptococcus pneumoniae TIGR4 930432 NP_345013.1 CDS SP_0495 NC_003028.3 472994 474340 R similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase complement(472994..474340) Streptococcus pneumoniae TIGR4 930433 NP_345014.1 CDS SP_0496 NC_003028.3 474605 476236 R Na/Pi cotransporter II-like protein complement(474605..476236) Streptococcus pneumoniae TIGR4 930434 NP_345015.1 CDS SP_0497 NC_003028.3 476438 476548 D hypothetical protein 476438..476548 Streptococcus pneumoniae TIGR4 930435 NP_345016.1 CDS SP_0498 NC_003028.3 476529 481508 D identified by match to PFAM protein family HMM PF00746; endo-beta-N-acetylglucosaminidase 476529..481508 Streptococcus pneumoniae TIGR4 930436 NP_345017.1 CDS pgk NC_003028.3 481598 482794 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 481598..482794 Streptococcus pneumoniae TIGR4 930437 NP_345018.1 CDS SP_0500 NC_003028.3 482930 483457 D similar to GB:AL009126; identified by sequence similarity; hypothetical protein 482930..483457 Streptococcus pneumoniae TIGR4 930438 NP_345019.1 CDS SP_0501 NC_003028.3 483534 483890 D MerR family transcriptional regulator 483534..483890 Streptococcus pneumoniae TIGR4 930439 NP_345020.1 CDS SP_0502 NC_003028.3 483927 485273 D identified by match to TIGR protein family HMM TIGR00653; glutamine synthetase, type I 483927..485273 Streptococcus pneumoniae TIGR4 930440 NP_345021.1 CDS SP_0503 NC_003028.3 485369 485488 R hypothetical protein complement(485369..485488) Streptococcus pneumoniae TIGR4 930441 NP_345022.1 CDS SP_0504 NC_003028.3 485746 485883 D hypothetical protein 485746..485883 Streptococcus pneumoniae TIGR4 930442 NP_345023.1 CDS SP_0505 NC_003028.3 486054 487334 D type I restriction-modification system subunit S 486054..487334 Streptococcus pneumoniae TIGR4 930443 NP_345024.1 CDS SP_0506 NC_003028.3 487391 488188 D phage integrase family integrase/recombinase 487391..488188 Streptococcus pneumoniae TIGR4 930444 NP_345025.1 CDS SP_0507 NC_003028.3 488259 488798 D type I restriction-modification system subunit S 488259..488798 Streptococcus pneumoniae TIGR4 930445 NP_345026.1 CDS SP_0508 NC_003028.3 488752 490320 R type I restriction-modification system subunit S complement(488752..490320) Streptococcus pneumoniae TIGR4 930446 NP_345027.1 CDS SP_0509 NC_003028.3 490320 491783 R type I restriction-modification system, M subunit complement(490320..491783) Streptococcus pneumoniae TIGR4 930447 NP_345028.1 CDS SP_0510 NC_003028.3 491796 494129 R type I restriction-modification system, R subunit complement(491796..494129) Streptococcus pneumoniae TIGR4 930448 NP_345029.1 CDS SP_0511 NC_003028.3 494480 494608 R hypothetical protein complement(494480..494608) Streptococcus pneumoniae TIGR4 930449 NP_345030.1 CDS SP_0512 NC_003028.3 494592 494702 D hypothetical protein 494592..494702 Streptococcus pneumoniae TIGR4 930450 NP_345031.1 CDS SP_0513 NC_003028.3 494737 494928 D hypothetical protein 494737..494928 Streptococcus pneumoniae TIGR4 930451 NP_345032.1 CDS SP_0514 NC_003028.3 494900 495247 D hypothetical protein 494900..495247 Streptococcus pneumoniae TIGR4 930452 NP_345033.1 CDS hrcA NC_003028.3 495411 496445 D Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 495411..496445 Streptococcus pneumoniae TIGR4 930453 NP_345034.1 CDS SP_0516 NC_003028.3 496472 496996 D with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 496472..496996 Streptococcus pneumoniae TIGR4 930454 NP_345035.1 CDS dnaK NC_003028.3 497485 499308 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 497485..499308 Streptococcus pneumoniae TIGR4 930455 NP_345036.1 CDS SP_0518 NC_003028.3 499310 499456 D hypothetical protein 499310..499456 Streptococcus pneumoniae TIGR4 930456 NP_345037.1 CDS SP_0519 NC_003028.3 500067 501203 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 500067..501203 Streptococcus pneumoniae TIGR4 930457 NP_345038.1 CDS SP_0520 NC_003028.3 501893 502180 R hypothetical protein complement(501893..502180) Streptococcus pneumoniae TIGR4 930459 NP_345039.1 CDS SP_0521 NC_003028.3 502190 502600 R identified by match to PFAM protein family HMM PF01230; HIT family protein complement(502190..502600) Streptococcus pneumoniae TIGR4 930460 NP_345040.1 CDS SP_0522 NC_003028.3 502668 503399 D ABC transporter ATP-binding protein 502668..503399 Streptococcus pneumoniae TIGR4 930461 NP_345041.1 CDS SP_0523 NC_003028.3 503396 504445 D similar to PID:1177254 SP:P55340 PID:2226114 GB:AL009126; identified by sequence similarity; ABC transporter permease 503396..504445 Streptococcus pneumoniae TIGR4 930463 NP_345042.1 CDS SP_0524 NC_003028.3 504613 504942 R similar to GP:9798558; identified by sequence similarity; BlpT protein, fusion complement(504613..504942) Streptococcus pneumoniae TIGR4 930464 NP_345043.1 CDS SP_0525 NC_003028.3 505218 505556 D similar to GP:9798559; identified by sequence similarity; BlpS protein 505218..505556 Streptococcus pneumoniae TIGR4 930465 NP_345044.1 CDS SP_0526 NC_003028.3 505561 506298 D response regulator BlpR 505561..506298 Streptococcus pneumoniae TIGR4 930466 NP_345045.1 CDS SP_0527 NC_003028.3 506312 507652 D similar to GP:5830551; identified by sequence similarity; sensor histidine kinase BlpH 506312..507652 Streptococcus pneumoniae TIGR4 930467 NP_345046.1 CDS SP_0528 NC_003028.3 507723 507851 R similar to GP:9798562; identified by sequence similarity; peptide pheromone BlpC complement(507723..507851) Streptococcus pneumoniae TIGR4 930468 NP_345047.1 CDS SP_0529 NC_003028.3 507908 509269 R BlpC ABC transporter complement(507908..509269) Streptococcus pneumoniae TIGR4 930469 NP_345048.1 CDS SP_0531 NC_003028.3 511719 511916 D similar to GP:9798565; identified by sequence similarity; bacteriocin BlpI 511719..511916 Streptococcus pneumoniae TIGR4 930471 NP_345049.1 CDS SP_0532 NC_003028.3 512383 512652 D similar to GP:9798566; identified by sequence similarity; bacteriocin BlpJ 512383..512652 Streptococcus pneumoniae TIGR4 930472 NP_345050.1 CDS SP_0533 NC_003028.3 512721 512951 D similar to GP:9798567; identified by sequence similarity; bacteriocin BlpK 512721..512951 Streptococcus pneumoniae TIGR4 930473 NP_345051.1 CDS SP_0534 NC_003028.3 513186 513302 D hypothetical protein 513186..513302 Streptococcus pneumoniae TIGR4 930474 NP_345052.1 CDS SP_0535 NC_003028.3 513370 513534 D hypothetical protein 513370..513534 Streptococcus pneumoniae TIGR4 930475 NP_345053.1 CDS SP_0536 NC_003028.3 513531 513935 D similar to GP:9798568; identified by sequence similarity; immunity protein BlpL 513531..513935 Streptococcus pneumoniae TIGR4 930476 NP_345054.1 CDS SP_0537 NC_003028.3 514138 514527 D similar to PID:763133; identified by sequence similarity; IS1381 transposase protein A 514138..514527 Streptococcus pneumoniae TIGR4 930477 NP_345055.1 CDS SP_0538 NC_003028.3 514553 514942 D similar to PID:763133; identified by sequence similarity; IS1381 transposase protein B 514553..514942 Streptococcus pneumoniae TIGR4 930478 NP_345056.1 CDS SP_0539 NC_003028.3 515092 515346 D similar to GP:9798569; identified by sequence similarity; bacteriocin BlpM 515092..515346 Streptococcus pneumoniae TIGR4 930479 NP_345057.1 CDS SP_0540 NC_003028.3 515362 515565 D similar to GP:9798570; identified by sequence similarity; BlpN protein 515362..515565 Streptococcus pneumoniae TIGR4 930481 NP_345058.1 CDS SP_0541 NC_003028.3 515809 515958 D similar to GP:9798571; identified by sequence similarity; bacteriocin BlpO 515809..515958 Streptococcus pneumoniae TIGR4 930482 NP_345059.1 CDS SP_0542 NC_003028.3 515940 516059 D hypothetical protein 515940..516059 Streptococcus pneumoniae TIGR4 930483 NP_345060.1 CDS SP_0543 NC_003028.3 516700 516867 D hypothetical protein 516700..516867 Streptococcus pneumoniae TIGR4 930484 NP_345061.1 CDS SP_0544 NC_003028.3 516952 517350 D similar to GP:9798572; identified by sequence similarity; immunity protein BlpX 516952..517350 Streptococcus pneumoniae TIGR4 930485 NP_345062.1 CDS SP_0545 NC_003028.3 517402 518091 D similar to PID:1495680; identified by sequence similarity; immunity protein BlpY 517402..518091 Streptococcus pneumoniae TIGR4 930486 NP_345063.1 CDS SP_0546 NC_003028.3 518133 518366 D similar to GP:9798574; identified by sequence similarity; hypothetical protein 518133..518366 Streptococcus pneumoniae TIGR4 930487 NP_345064.1 CDS SP_0547 NC_003028.3 518517 519128 D similar to GB:AL009126; identified by sequence similarity; hypothetical protein 518517..519128 Streptococcus pneumoniae TIGR4 930488 NP_345065.1 CDS SP_0548 NC_003028.3 519222 519344 R hypothetical protein complement(519222..519344) Streptococcus pneumoniae TIGR4 930489 NP_345066.1 CDS SP_0549 NC_003028.3 519352 520083 D hypothetical protein 519352..520083 Streptococcus pneumoniae TIGR4 930490 NP_345067.1 CDS trmB NC_003028.3 520080 520715 D tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 520080..520715 Streptococcus pneumoniae TIGR4 930494 NP_345068.1 CDS SP_0552 NC_003028.3 520841 521320 D in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 520841..521320 Streptococcus pneumoniae TIGR4 930495 NP_345069.1 CDS nusA NC_003028.3 521364 522500 D modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 521364..522500 Streptococcus pneumoniae TIGR4 930496 NP_345070.1 CDS SP_0554 NC_003028.3 522522 522815 D hypothetical protein 522522..522815 Streptococcus pneumoniae TIGR4 930497 NP_345071.1 CDS SP_0555 NC_003028.3 522808 523107 D identified by match to PFAM protein family HMM PF01248; hypothetical protein 522808..523107 Streptococcus pneumoniae TIGR4 930498 NP_345072.1 CDS infB NC_003028.3 523124 526000 D Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 523124..526000 Streptococcus pneumoniae TIGR4 930499 NP_345073.1 CDS rbfA NC_003028.3 526251 526601 D associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 526251..526601 Streptococcus pneumoniae TIGR4 930500 NP_345074.1 CDS SP_0558 NC_003028.3 526844 527659 D hypothetical protein 526844..527659 Streptococcus pneumoniae TIGR4 930501 NP_345075.1 CDS SP_0559 NC_003028.3 527661 527843 D hypothetical protein 527661..527843 Streptococcus pneumoniae TIGR4 930502 NP_345076.1 CDS SP_0560 NC_003028.3 527796 528029 R hypothetical protein complement(527796..528029) Streptococcus pneumoniae TIGR4 930504 NP_345077.1 CDS SP_0561 NC_003028.3 528291 528536 D similar to GB:AE000782; identified by sequence similarity; hypothetical protein 528291..528536 Streptococcus pneumoniae TIGR4 930505 NP_345078.1 CDS SP_0562 NC_003028.3 528536 529870 D hypothetical protein 528536..529870 Streptococcus pneumoniae TIGR4 930506 NP_345079.1 CDS SP_0563 NC_003028.3 529880 530134 D hypothetical protein 529880..530134 Streptococcus pneumoniae TIGR4 930507 NP_345080.1 CDS SP_0564 NC_003028.3 530230 530625 D hypothetical protein 530230..530625 Streptococcus pneumoniae TIGR4 930508 NP_345081.1 CDS SP_0565 NC_003028.3 531038 531487 D similar to GP:8927331; identified by sequence similarity; hypothetical protein 531038..531487 Streptococcus pneumoniae TIGR4 930509 NP_345082.1 CDS SP_0566 NC_003028.3 531474 532034 D acetyltransferase 531474..532034 Streptococcus pneumoniae TIGR4 930510 NP_345083.1 CDS SP_0567 NC_003028.3 532019 532612 D hypothetical protein 532019..532612 Streptococcus pneumoniae TIGR4 930511 NP_345084.1 CDS valS NC_003028.3 532605 535256 D valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 532605..535256 Streptococcus pneumoniae TIGR4 930512 YP_003104753.1 CDS SP_0569 NC_003028.3 535337 535501 D type II DNA modification methyltransferase 535337..535501 Streptococcus pneumoniae TIGR4 930513 NP_345085.1 CDS SP_0570 NC_003028.3 535552 537156 D similar to GP:2687741; identified by sequence similarity; hypothetical protein 535552..537156 Streptococcus pneumoniae TIGR4 930514 NP_345086.1 CDS SP_0571 NC_003028.3 537536 538339 D cell filamentation protein Fic-like protein 537536..538339 Streptococcus pneumoniae TIGR4 930515 NP_345087.1 CDS SP_0573 NC_003028.3 539917 540078 D hypothetical protein 539917..540078 Streptococcus pneumoniae TIGR4 930517 NP_345088.1 CDS SP_0574 NC_003028.3 540202 541032 D hypothetical protein 540202..541032 Streptococcus pneumoniae TIGR4 930518 NP_345089.1 CDS SP_0575 NC_003028.3 541218 542864 D helicase 541218..542864 Streptococcus pneumoniae TIGR4 930519 NP_345090.1 CDS SP_0576 NC_003028.3 543164 544003 D identified by match to PFAM protein family HMM PF00874; transcription antiterminator Lict 543164..544003 Streptococcus pneumoniae TIGR4 930520 NP_345091.1 CDS SP_0577 NC_003028.3 544021 545859 D PTS system beta-glucosides-specific transporter subunit IIABC 544021..545859 Streptococcus pneumoniae TIGR4 930521 NP_345092.1 CDS SP_0578 NC_003028.3 545872 547287 D 6-phospho-beta-glucosidase 545872..547287 Streptococcus pneumoniae TIGR4 930522 NP_345093.1 CDS pheS NC_003028.3 547769 548815 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 547769..548815 Streptococcus pneumoniae TIGR4 930523 NP_345094.1 CDS SP_0580 NC_003028.3 548815 549324 D acetyltransferase 548815..549324 Streptococcus pneumoniae TIGR4 930524 NP_345095.1 CDS pheT NC_003028.3 549401 551806 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 549401..551806 Streptococcus pneumoniae TIGR4 930525 NP_345096.1 CDS SP_0582 NC_003028.3 551874 552875 R hypothetical protein complement(551874..552875) Streptococcus pneumoniae TIGR4 930528 NP_345097.1 CDS SP_0584 NC_003028.3 553626 553838 D transcriptional regulator 553626..553838 Streptococcus pneumoniae TIGR4 930530 NP_345098.1 CDS SP_0585 NC_003028.3 554099 556348 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 554099..556348 Streptococcus pneumoniae TIGR4 930531 NP_345099.1 CDS SP_0586 NC_003028.3 556412 557278 D identified by match to PFAM protein family HMM PF02219; 5,10-methylenetetrahydrofolate reductase 556412..557278 Streptococcus pneumoniae TIGR4 930532 NP_345100.1 CDS SP_0587 NC_003028.3 557460 557729 R hypothetical protein complement(557460..557729) Streptococcus pneumoniae TIGR4 930533 NP_345101.1 CDS SP_0588 NC_003028.3 557963 560176 D identified by match to PFAM protein family HMM PF01138; polynucleotide phosphorylase 557963..560176 Streptococcus pneumoniae TIGR4 930534 NP_345102.1 CDS SP_0589 NC_003028.3 560192 560809 D identified by match to TIGR protein family HMM TIGR01172; serine acetyltransferase 560192..560809 Streptococcus pneumoniae TIGR4 930535 NP_345103.1 CDS SP_0590 NC_003028.3 560821 561705 D acetyltransferase 560821..561705 Streptococcus pneumoniae TIGR4 930536 NP_345104.1 CDS cysS NC_003028.3 561787 563130 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 561787..563130 Streptococcus pneumoniae TIGR4 930537 NP_345105.1 CDS SP_0592 NC_003028.3 563123 563509 D hypothetical protein 563123..563509 Streptococcus pneumoniae TIGR4 930538 NP_345106.1 CDS SP_0593 NC_003028.3 563513 564397 D hypothetical protein 563513..564397 Streptococcus pneumoniae TIGR4 930539 NP_345108.1 CDS SP_0595 NC_003028.3 564534 564989 D hypothetical protein 564534..564989 Streptococcus pneumoniae TIGR4 930541 NP_345109.1 CDS SP_0596 NC_003028.3 564986 565132 D hypothetical protein 564986..565132 Streptococcus pneumoniae TIGR4 930542 NP_345110.1 CDS SP_0598 NC_003028.3 565789 565953 D hypothetical protein 565789..565953 Streptococcus pneumoniae TIGR4 930545 NP_345111.1 CDS SP_0599 NC_003028.3 565916 567079 D similar to GP:5712667; identified by sequence similarity; transmembrane protein Vexp1 565916..567079 Streptococcus pneumoniae TIGR4 930546 NP_345112.1 CDS SP_0600 NC_003028.3 567092 567739 D ABC transporter ATP-binding protein 567092..567739 Streptococcus pneumoniae TIGR4 930547 NP_345113.1 CDS SP_0601 NC_003028.3 567791 569170 D similar to GP:5712669; identified by sequence similarity; transmembrane protein Vexp3 567791..569170 Streptococcus pneumoniae TIGR4 930549 NP_345115.1 CDS SP_0603 NC_003028.3 569482 570138 D DNA-binding response regulator VncR 569482..570138 Streptococcus pneumoniae TIGR4 930551 NP_345116.1 CDS SP_0604 NC_003028.3 570135 571463 D sensor histidine kinase VncS 570135..571463 Streptococcus pneumoniae TIGR4 930552 NP_345117.1 CDS SP_0605 NC_003028.3 571604 572485 D catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 571604..572485 Streptococcus pneumoniae TIGR4 930553 NP_345118.1 CDS SP_0606 NC_003028.3 572806 574008 R oxidoreductase complement(572806..574008) Streptococcus pneumoniae TIGR4 930555 NP_345119.1 CDS SP_0607 NC_003028.3 574254 574913 R amino acid ABC transporter permease complement(574254..574913) Streptococcus pneumoniae TIGR4 930556 NP_345120.1 CDS SP_0608 NC_003028.3 574923 575600 R amino acid ABC transporter permease complement(574923..575600) Streptococcus pneumoniae TIGR4 930557 NP_345121.1 CDS SP_0609 NC_003028.3 575613 576377 R amino acid ABC transporter amino acid-binding protein complement(575613..576377) Streptococcus pneumoniae TIGR4 930558 NP_345122.1 CDS SP_0610 NC_003028.3 576417 577175 R amino acid ABC transporter ATP-binding protein complement(576417..577175) Streptococcus pneumoniae TIGR4 930559 NP_345123.2 CDS SP_0611 NC_003028.3 577452 579674 D identified by match to PFAM protein family HMM PF02272; single-stranded-DNA-specific exonuclease RecJ 577452..579674 Streptococcus pneumoniae TIGR4 930560 NP_345124.1 CDS SP_0612 NC_003028.3 579708 579806 D hypothetical protein 579708..579806 Streptococcus pneumoniae TIGR4 930561 NP_345125.1 CDS SP_0613 NC_003028.3 579849 581510 D identified by match to PFAM protein family HMM PF02147; metallo-beta-lactamase superfamily protein 579849..581510 Streptococcus pneumoniae TIGR4 930562 NP_345126.1 CDS SP_0614 NC_003028.3 581579 582358 D tributyrin esterase 581579..582358 Streptococcus pneumoniae TIGR4 930563 NP_345127.1 CDS SP_0615 NC_003028.3 582470 583690 D similar to GP:7649681; identified by sequence similarity; beta-lactam resistance factor 582470..583690 Streptococcus pneumoniae TIGR4 930564 NP_345128.1 CDS SP_0616 NC_003028.3 583695 584927 D similar to GP:7649683; identified by sequence similarity; beta-lactam resistance factor 583695..584927 Streptococcus pneumoniae TIGR4 930565 NP_345129.1 CDS SP_0617 NC_003028.3 584985 585707 D hypothetical protein 584985..585707 Streptococcus pneumoniae TIGR4 930566 NP_345130.1 CDS uvrC NC_003028.3 585747 587591 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 585747..587591 Streptococcus pneumoniae TIGR4 930567 NP_345131.1 CDS SP_0619 NC_003028.3 587581 588414 D hypothetical protein 587581..588414 Streptococcus pneumoniae TIGR4 930568 NP_345132.1 CDS SP_0620 NC_003028.3 588596 589396 R amino acid ABC transporter amino acid-binding protein complement(588596..589396) Streptococcus pneumoniae TIGR4 930569 NP_345133.1 CDS SP_0621 NC_003028.3 589470 589580 D hypothetical protein 589470..589580 Streptococcus pneumoniae TIGR4 930570 NP_345134.1 CDS SP_0622 NC_003028.3 589567 590172 D identified by match to PFAM protein family HMM PF00881; nitroreductase 589567..590172 Streptococcus pneumoniae TIGR4 930571 NP_345135.1 CDS SP_0623 NC_003028.3 590185 591585 D divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 590185..591585 Streptococcus pneumoniae TIGR4 930572 NP_345136.1 CDS SP_0624 NC_003028.3 591639 592217 D hypothetical protein 591639..592217 Streptococcus pneumoniae TIGR4 930573 NP_345137.1 CDS SP_0626 NC_003028.3 592820 594160 D identified by match to TIGR protein family HMM TIGR00796; branched-chain amino acid transport system II carrier protein 592820..594160 Streptococcus pneumoniae TIGR4 930575 NP_345138.1 CDS SP_0627 NC_003028.3 594258 595295 D hypothetical protein 594258..595295 Streptococcus pneumoniae TIGR4 930576 NP_345139.1 CDS SP_0628 NC_003028.3 595264 595767 D similar to SP:Q04344 PID:1431187 PID:3499; identified by sequence similarity; HIT family protein 595264..595767 Streptococcus pneumoniae TIGR4 930577 NP_345140.1 CDS SP_0629 NC_003028.3 595770 596486 D hypothetical protein 595770..596486 Streptococcus pneumoniae TIGR4 930578 NP_345141.1 CDS rplK NC_003028.3 596795 597220 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 596795..597220 Streptococcus pneumoniae TIGR4 930579 NP_345142.1 CDS rplA NC_003028.3 597427 598116 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 597427..598116 Streptococcus pneumoniae TIGR4 930580 NP_345143.1 CDS SP_0633 NC_003028.3 598658 599020 D hypothetical protein 598658..599020 Streptococcus pneumoniae TIGR4 930582 NP_345144.1 CDS SP_0634 NC_003028.3 599323 599664 D similar to GP:7160903; identified by sequence similarity; hypothetical protein 599323..599664 Streptococcus pneumoniae TIGR4 930583 NP_345145.1 CDS SP_0635 NC_003028.3 599592 599759 R hypothetical protein complement(599592..599759) Streptococcus pneumoniae TIGR4 930584 NP_345146.1 CDS SP_0636 NC_003028.3 600065 601057 D ABC transporter ATP-binding protein 600065..601057 Streptococcus pneumoniae TIGR4 930585 NP_345147.1 CDS SP_0637 NC_003028.3 601059 601877 D similar to GP:7636000; identified by sequence similarity; hypothetical protein 601059..601877 Streptococcus pneumoniae TIGR4 930586 NP_345148.1 CDS SP_0638 NC_003028.3 601879 602664 D hypothetical protein 601879..602664 Streptococcus pneumoniae TIGR4 930587 NP_345149.1 CDS SP_0639 NC_003028.3 602700 602981 D hypothetical protein 602700..602981 Streptococcus pneumoniae TIGR4 930588 NP_345150.1 CDS SP_0640 NC_003028.3 602918 603163 D hypothetical protein 602918..603163 Streptococcus pneumoniae TIGR4 930589 NP_345151.1 CDS SP_0641 NC_003028.3 603895 610317 D identified by match to PFAM protein family HMM PF00746; serine protease 603895..610317 Streptococcus pneumoniae TIGR4 930590 NP_345152.1 CDS SP_0645 NC_003028.3 612684 613181 D PTS system transporter subunit IIA 612684..613181 Streptococcus pneumoniae TIGR4 930594 NP_345153.1 CDS SP_0646 NC_003028.3 613219 613524 D similar to SP:P37188 GB:X79837 PID:508174 GB:U00096 PID:1736810; identified by sequence similarity; PTS system transporter subunit IIB 613219..613524 Streptococcus pneumoniae TIGR4 930595 NP_345154.1 CDS SP_0647 NC_003028.3 613572 615047 D PTS system transporter subunit IIC 613572..615047 Streptococcus pneumoniae TIGR4 930596 NP_345155.1 CDS SP_0648 NC_003028.3 615442 622143 D identified by match to PFAM protein family HMM PF00703; beta-galactosidase 615442..622143 Streptococcus pneumoniae TIGR4 930597 NP_345156.1 CDS SP_0650 NC_003028.3 623457 623777 R hypothetical protein complement(623457..623777) Streptococcus pneumoniae TIGR4 930599 NP_345157.1 CDS SP_0652 NC_003028.3 624848 625405 D hypothetical protein 624848..625405 Streptococcus pneumoniae TIGR4 930601 NP_345158.1 CDS SP_0653 NC_003028.3 625398 625652 D hypothetical protein 625398..625652 Streptococcus pneumoniae TIGR4 930602 NP_345159.1 CDS SP_0654 NC_003028.3 625627 625728 D hypothetical protein 625627..625728 Streptococcus pneumoniae TIGR4 930603 NP_345160.2 CDS SP_0655 NC_003028.3 625664 627718 D identified by match to PFAM protein family HMM PF00999; sodium/hydrogen exchanger family protein 625664..627718 Streptococcus pneumoniae TIGR4 930604 NP_345162.1 CDS SP_0657 NC_003028.3 627897 628757 D ribonuclease BN 627897..628757 Streptococcus pneumoniae TIGR4 930606 NP_345163.1 CDS SP_0658 NC_003028.3 628968 629678 D similar to GP:6714962; identified by sequence similarity; cytochrome c-type biogenesis protein CcdA 628968..629678 Streptococcus pneumoniae TIGR4 930607 NP_345164.1 CDS SP_0659 NC_003028.3 629698 630264 D thioredoxin 629698..630264 Streptococcus pneumoniae TIGR4 930608 NP_345165.1 CDS SP_0660 NC_003028.3 630452 631387 D this fusion consists of methionine sulfoxide A reductase at the N-terminus and B at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion; bifunctional methionine sulfoxide reductase A/B 630452..631387 Streptococcus pneumoniae TIGR4 930609 NP_345166.1 CDS SP_0661 NC_003028.3 631655 632392 D DNA-binding response regulator 631655..632392 Streptococcus pneumoniae TIGR4 930610 NP_345167.1 CDS SP_0662 NC_003028.3 632389 634080 D sensor histidine kinase 632389..634080 Streptococcus pneumoniae TIGR4 930611 NP_345168.1 CDS SP_0663 NC_003028.3 634196 634759 D hypothetical protein 634196..634759 Streptococcus pneumoniae TIGR4 930612 NP_345169.1 CDS SP_0664 NC_003028.3 634856 640501 D identified by match to PFAM protein family HMM PF00746; zinc metalloprotease ZmpB 634856..640501 Streptococcus pneumoniae TIGR4 930613 NP_345170.1 CDS SP_0665 NC_003028.3 640562 642283 D identified by match to PFAM protein family HMM PF00425; chorismate binding protein 640562..642283 Streptococcus pneumoniae TIGR4 930614 NP_345171.1 CDS SP_0666 NC_003028.3 642284 642901 D hypothetical protein 642284..642901 Streptococcus pneumoniae TIGR4 930615 NP_345172.1 CDS SP_0667 NC_003028.3 642951 643949 D surface protein 642951..643949 Streptococcus pneumoniae TIGR4 930616 NP_345173.2 CDS SP_0668 NC_003028.3 644073 645035 D glucokinase 644073..645035 Streptococcus pneumoniae TIGR4 930617 NP_345174.1 CDS thyA NC_003028.3 645132 645971 D ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 645132..645971 Streptococcus pneumoniae TIGR4 930618 NP_345175.1 CDS SP_0670 NC_003028.3 646019 646189 R hypothetical protein complement(646019..646189) Streptococcus pneumoniae TIGR4 930619 NP_345176.1 CDS miaA NC_003028.3 646310 647194 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 646310..647194 Streptococcus pneumoniae TIGR4 930620 NP_345177.1 CDS SP_0672 NC_003028.3 647187 648425 D GTP-binding protein HflX 647187..648425 Streptococcus pneumoniae TIGR4 930621 NP_345178.1 CDS SP_0673 NC_003028.3 648418 649041 D hypothetical protein 648418..649041 Streptococcus pneumoniae TIGR4 930622 NP_345179.1 CDS SP_0674 NC_003028.3 649056 649985 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 649056..649985 Streptococcus pneumoniae TIGR4 930623 NP_345180.1 CDS SP_0675 NC_003028.3 650006 650761 D short chain dehydrogenase/reductase family oxidoreductase 650006..650761 Streptococcus pneumoniae TIGR4 930624 NP_345181.1 CDS SP_0676 NC_003028.3 650815 651783 R transcriptional regulator complement(650815..651783) Streptococcus pneumoniae TIGR4 930625 NP_345182.1 CDS SP_0677 NC_003028.3 651835 652056 D hypothetical protein 651835..652056 Streptococcus pneumoniae TIGR4 930626 NP_345183.1 CDS SP_0678 NC_003028.3 652056 652436 D hypothetical protein 652056..652436 Streptococcus pneumoniae TIGR4 930627 NP_345184.1 CDS SP_0679 NC_003028.3 652555 652752 D hypothetical protein 652555..652752 Streptococcus pneumoniae TIGR4 930628 NP_345185.1 CDS SP_0680 NC_003028.3 652792 653517 R ribosomal small subunit pseudouridine synthase A complement(652792..653517) Streptococcus pneumoniae TIGR4 930629 NP_345186.1 CDS SP_0681 NC_003028.3 653679 655520 D elongation factor Tu family protein 653679..655520 Streptococcus pneumoniae TIGR4 930630 NP_345187.1 CDS SP_0682 NC_003028.3 655540 655794 D hypothetical protein 655540..655794 Streptococcus pneumoniae TIGR4 930631 NP_345188.1 CDS SP_0683 NC_003028.3 655988 656086 R hypothetical protein complement(655988..656086) Streptococcus pneumoniae TIGR4 930632 NP_345189.1 CDS SP_0684 NC_003028.3 656249 656344 D hypothetical protein 656249..656344 Streptococcus pneumoniae TIGR4 930633 NP_345190.1 CDS SP_0685 NC_003028.3 656341 656433 D hypothetical protein 656341..656433 Streptococcus pneumoniae TIGR4 930634 NP_345191.1 CDS SP_0686 NC_003028.3 656527 658548 D hypothetical protein 656527..658548 Streptococcus pneumoniae TIGR4 930636 NP_345192.1 CDS SP_0687 NC_003028.3 658550 659191 D ABC transporter ATP-binding protein 658550..659191 Streptococcus pneumoniae TIGR4 930637 NP_345193.1 CDS murD NC_003028.3 659295 660647 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 659295..660647 Streptococcus pneumoniae TIGR4 930638 NP_345194.1 CDS murG NC_003028.3 660649 661707 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 660649..661707 Streptococcus pneumoniae TIGR4 930639 NP_345195.1 CDS SP_0690 NC_003028.3 661717 662916 D similar to GP:4009482; identified by sequence similarity; cell division protein DivIB 661717..662916 Streptococcus pneumoniae TIGR4 930640 NP_345196.1 CDS SP_0691 NC_003028.3 663026 663172 D hypothetical protein 663026..663172 Streptococcus pneumoniae TIGR4 930641 NP_345197.1 CDS SP_0692 NC_003028.3 663184 663315 D hypothetical protein 663184..663315 Streptococcus pneumoniae TIGR4 930642 NP_345198.1 CDS SP_0693 NC_003028.3 663498 663614 D hypothetical protein 663498..663614 Streptococcus pneumoniae TIGR4 930643 NP_345199.1 CDS SP_0694 NC_003028.3 663748 664311 D hypothetical protein 663748..664311 Streptococcus pneumoniae TIGR4 930644 NP_345200.1 CDS SP_0695 NC_003028.3 664654 665289 D identified by match to PFAM protein family HMM PF00899; HesA/MoeB/ThiF family protein 664654..665289 Streptococcus pneumoniae TIGR4 930645 NP_345201.1 CDS SP_0696 NC_003028.3 665286 665666 D hypothetical protein 665286..665666 Streptococcus pneumoniae TIGR4 930646 NP_345202.1 CDS SP_0698 NC_003028.3 666702 667415 D hypothetical protein 666702..667415 Streptococcus pneumoniae TIGR4 930648 NP_345203.1 CDS SP_0699 NC_003028.3 667416 667514 D hypothetical protein 667416..667514 Streptococcus pneumoniae TIGR4 930649 NP_345204.1 CDS SP_0701 NC_003028.3 668161 668862 D OMP decarboxylase; OMPDCase; OMPdecase; type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 668161..668862 Streptococcus pneumoniae TIGR4 930651 NP_345205.1 CDS pyrE NC_003028.3 668896 669528 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 668896..669528 Streptococcus pneumoniae TIGR4 930652 NP_345206.1 CDS SP_0703 NC_003028.3 669761 670111 D hypothetical protein 669761..670111 Streptococcus pneumoniae TIGR4 930653 NP_345207.1 CDS SP_0704 NC_003028.3 670207 670971 D hypothetical protein 670207..670971 Streptococcus pneumoniae TIGR4 930654 NP_345208.1 CDS SP_0705 NC_003028.3 670920 671723 D hypothetical protein 670920..671723 Streptococcus pneumoniae TIGR4 930655 NP_345209.1 CDS SP_0706 NC_003028.3 671727 672431 D hypothetical protein 671727..672431 Streptococcus pneumoniae TIGR4 930656 NP_345210.1 CDS SP_0707 NC_003028.3 672428 673075 D ABC transporter ATP-binding protein 672428..673075 Streptococcus pneumoniae TIGR4 930657 NP_345211.1 CDS SP_0709 NC_003028.3 674045 674803 R amino acid ABC transporter ATP-binding protein complement(674045..674803) Streptococcus pneumoniae TIGR4 930659 NP_345212.1 CDS SP_0710 NC_003028.3 674804 675481 R amino acid ABC transporter permease complement(674804..675481) Streptococcus pneumoniae TIGR4 930660 NP_345213.1 CDS SP_0711 NC_003028.3 675441 676061 R amino acid ABC transporter permease complement(675441..676061) Streptococcus pneumoniae TIGR4 930661 NP_345214.3 CDS lysS NC_003028.3 676624 678099 D class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 676624..678099 Streptococcus pneumoniae TIGR4 930663 NP_345215.1 CDS SP_0714 NC_003028.3 678711 680057 R similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase complement(678711..680057) Streptococcus pneumoniae TIGR4 930664 NP_345216.1 CDS SP_0715 NC_003028.3 680430 681566 D identified by match to PFAM protein family HMM PF01070; lactate oxidase 680430..681566 Streptococcus pneumoniae TIGR4 930665 NP_345217.1 CDS SP_0716 NC_003028.3 682123 682791 D similar to GB:X59720 SP:P25362 PID:1907163; identified by sequence similarity; transcriptional regulator 682123..682791 Streptococcus pneumoniae TIGR4 930666 NP_345218.1 CDS SP_0717 NC_003028.3 683028 683810 D catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 683028..683810 Streptococcus pneumoniae TIGR4 930667 NP_345219.1 CDS SP_0718 NC_003028.3 683812 684441 D thiamine-phosphate pyrophosphorylase 683812..684441 Streptococcus pneumoniae TIGR4 930668 NP_345220.1 CDS SP_0719 NC_003028.3 685000 685560 D hypothetical protein 685000..685560 Streptococcus pneumoniae TIGR4 930669 NP_345221.1 CDS SP_0720 NC_003028.3 685561 686946 D ABC transporter ATP-binding protein 685561..686946 Streptococcus pneumoniae TIGR4 930670 NP_345222.1 CDS SP_0721 NC_003028.3 686948 687598 D hypothetical protein 686948..687598 Streptococcus pneumoniae TIGR4 930671 NP_345223.1 CDS SP_0722 NC_003028.3 687609 688301 D similar to GB:M73546 SP:P25052 PID:143729 GB:AL009126; identified by sequence similarity; transcriptional activator TenA 687609..688301 Streptococcus pneumoniae TIGR4 930672 NP_345224.1 CDS SP_0723 NC_003028.3 688306 688830 D similar to GB:NC_000854; identified by sequence similarity; hypothetical protein 688306..688830 Streptococcus pneumoniae TIGR4 930673 NP_345225.1 CDS SP_0724 NC_003028.3 688830 689633 D hydroxyethylthiazole kinase 688830..689633 Streptococcus pneumoniae TIGR4 930674 NP_345226.1 CDS thiE NC_003028.3 689626 690258 D Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 689626..690258 Streptococcus pneumoniae TIGR4 930675 NP_345227.1 CDS SP_0726 NC_003028.3 690468 691259 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(690468..691259) Streptococcus pneumoniae TIGR4 930676 NP_345228.1 CDS SP_0727 NC_003028.3 691619 692020 D transcriptional repressor 691619..692020 Streptococcus pneumoniae TIGR4 930677 NP_345229.1 CDS SP_0728 NC_003028.3 692031 692402 D hypothetical protein 692031..692402 Streptococcus pneumoniae TIGR4 930678 NP_345230.1 CDS SP_0729 NC_003028.3 692673 694655 D cation transporter E1-E2 family ATPase 692673..694655 Streptococcus pneumoniae TIGR4 930679 NP_345231.1 CDS SP_0730 NC_003028.3 694862 696637 D pyruvate oxidase 694862..696637 Streptococcus pneumoniae TIGR4 930680 NP_345232.1 CDS SP_0731 NC_003028.3 696748 697095 D similar to GP:7981392; identified by sequence similarity; hypothetical protein 696748..697095 Streptococcus pneumoniae TIGR4 930681 NP_345233.1 CDS SP_0733 NC_003028.3 697742 698008 R hypothetical protein complement(697742..698008) Streptococcus pneumoniae TIGR4 930683 NP_345234.1 CDS SP_0734 NC_003028.3 698363 698458 R hypothetical protein complement(698363..698458) Streptococcus pneumoniae TIGR4 930684 NP_345235.1 CDS SP_0736 NC_003028.3 698940 699884 D identified by match to PFAM protein family HMM PF01238; mannose-6-phosphate isomerase 698940..699884 Streptococcus pneumoniae TIGR4 930686 NP_345236.1 CDS SP_0737 NC_003028.3 699905 701176 R sodium-dependent transporter complement(699905..701176) Streptococcus pneumoniae TIGR4 930687 NP_345237.1 CDS SP_0738 NC_003028.3 701173 701400 R hypothetical protein complement(701173..701400) Streptococcus pneumoniae TIGR4 930688 NP_345238.1 CDS SP_0739 NC_003028.3 701499 702239 D MerR family transcriptional regulator 701499..702239 Streptococcus pneumoniae TIGR4 930689 NP_345239.1 CDS SP_0740 NC_003028.3 702268 702723 R MutT/nudix family protein complement(702268..702723) Streptococcus pneumoniae TIGR4 930690 NP_345240.1 CDS SP_0741 NC_003028.3 702743 703918 R hypothetical protein complement(702743..703918) Streptococcus pneumoniae TIGR4 930691 NP_345241.1 CDS SP_0742 NC_003028.3 703977 704822 R hypothetical protein complement(703977..704822) Streptococcus pneumoniae TIGR4 930692 NP_345242.1 CDS SP_0743 NC_003028.3 704947 705504 D TetR family transcriptional regulator 704947..705504 Streptococcus pneumoniae TIGR4 930693 NP_345243.1 CDS SP_0744 NC_003028.3 705523 705990 D cytidine and deoxycytidylate deaminase 705523..705990 Streptococcus pneumoniae TIGR4 930694 NP_345244.1 CDS upp NC_003028.3 706079 706708 D Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 706079..706708 Streptococcus pneumoniae TIGR4 930695 NP_345245.1 CDS clpP NC_003028.3 706882 707472 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 706882..707472 Streptococcus pneumoniae TIGR4 930696 NP_345246.1 CDS SP_0747 NC_003028.3 707469 707567 R hypothetical protein complement(707469..707567) Streptococcus pneumoniae TIGR4 930697 NP_345247.1 CDS SP_0748 NC_003028.3 707551 707799 D hypothetical protein 707551..707799 Streptococcus pneumoniae TIGR4 930698 NP_345248.1 CDS SP_0749 NC_003028.3 707900 709060 D branched-chain amino acid ABC transporter substrate-binding protein 707900..709060 Streptococcus pneumoniae TIGR4 930699 NP_345249.1 CDS SP_0750 NC_003028.3 709328 710197 D branched-chain amino acid ABC transporter permease 709328..710197 Streptococcus pneumoniae TIGR4 930700 NP_345250.1 CDS SP_0751 NC_003028.3 710201 711157 D branched-chain amino acid ABC transporter permease 710201..711157 Streptococcus pneumoniae TIGR4 930701 NP_345251.1 CDS SP_0752 NC_003028.3 711157 711921 D branched-chain amino acid ABC transporter ATP-binding protein 711157..711921 Streptococcus pneumoniae TIGR4 930702 NP_345252.1 CDS SP_0753 NC_003028.3 711921 712631 D branched-chain amino acid ABC transporter ATP-binding protein 711921..712631 Streptococcus pneumoniae TIGR4 930703 NP_345253.1 CDS SP_0754 NC_003028.3 712939 713595 D acetoin utilization protein AcuB 712939..713595 Streptococcus pneumoniae TIGR4 930704 YP_873927.1 CDS prfB NC_003028.3 713703 714798 D recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 join(713703..713774,713776..714798) Streptococcus pneumoniae TIGR4 930705 NP_345254.1 CDS SP_0756 NC_003028.3 714816 715508 D cell division ABC transporter ATP-binding protein FtsE 714816..715508 Streptococcus pneumoniae TIGR4 930706 NP_345255.1 CDS SP_0757 NC_003028.3 715501 716427 D cell division ABC transporter permease FtsX 715501..716427 Streptococcus pneumoniae TIGR4 930707 NP_345256.1 CDS SP_0758 NC_003028.3 716713 718893 D PTS system transporter subunit IIABC 716713..718893 Streptococcus pneumoniae TIGR4 930708 NP_345257.1 CDS SP_0759 NC_003028.3 718899 719018 D hypothetical protein 718899..719018 Streptococcus pneumoniae TIGR4 930709 NP_345258.1 CDS SP_0760 NC_003028.3 719074 719760 D hypothetical protein 719074..719760 Streptococcus pneumoniae TIGR4 930710 NP_345259.1 CDS SP_0761 NC_003028.3 719900 721243 D DEAD/DEAH box helicase 719900..721243 Streptococcus pneumoniae TIGR4 930711 NP_345260.1 CDS SP_0762 NC_003028.3 721458 722648 D methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 721458..722648 Streptococcus pneumoniae TIGR4 930712 NP_345261.1 CDS SP_0763 NC_003028.3 722939 723067 D hypothetical protein 722939..723067 Streptococcus pneumoniae TIGR4 930713 NP_345262.1 CDS SP_0764 NC_003028.3 723201 724136 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 723201..724136 Streptococcus pneumoniae TIGR4 930714 NP_345263.1 CDS holA NC_003028.3 724170 725207 D required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 724170..725207 Streptococcus pneumoniae TIGR4 930715 NP_345264.1 CDS SP_0766 NC_003028.3 725380 725985 D superoxide dismutase, manganese-dependent 725380..725985 Streptococcus pneumoniae TIGR4 930716 NP_345265.1 CDS SP_0767 NC_003028.3 726141 726653 D hypothetical protein 726141..726653 Streptococcus pneumoniae TIGR4 930717 NP_345266.1 CDS SP_0768 NC_003028.3 726674 727759 D 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 726674..727759 Streptococcus pneumoniae TIGR4 930718 NP_345267.1 CDS SP_0769 NC_003028.3 727762 728241 D similar to GP:7110140; identified by sequence similarity; VanZF-related protein 727762..728241 Streptococcus pneumoniae TIGR4 930719 NP_345268.1 CDS SP_0770 NC_003028.3 728243 729784 D ABC transporter ATP-binding protein 728243..729784 Streptococcus pneumoniae TIGR4 930720 NP_345269.1 CDS SP_0771 NC_003028.3 729840 730643 R cyclophilin type peptidyl-prolyl cis-trans isomerase complement(729840..730643) Streptococcus pneumoniae TIGR4 930721 NP_345270.1 CDS SP_0772 NC_003028.3 730727 730930 R hypothetical protein complement(730727..730930) Streptococcus pneumoniae TIGR4 930722 NP_345271.1 CDS SP_0773 NC_003028.3 731337 731435 D hypothetical protein 731337..731435 Streptococcus pneumoniae TIGR4 930723 NP_345272.1 CDS SP_0774 NC_003028.3 731419 731628 R hypothetical protein complement(731419..731628) Streptococcus pneumoniae TIGR4 930724 NP_345273.1 CDS rpsP NC_003028.3 731798 732070 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 731798..732070 Streptococcus pneumoniae TIGR4 930725 NP_345274.1 CDS SP_0776 NC_003028.3 732090 732329 D KH domain-containing protein 732090..732329 Streptococcus pneumoniae TIGR4 930726 NP_345275.1 CDS SP_0777 NC_003028.3 732894 733694 D hypothetical protein 732894..733694 Streptococcus pneumoniae TIGR4 930727 NP_345276.1 CDS rimM NC_003028.3 733725 734243 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 733725..734243 Streptococcus pneumoniae TIGR4 930728 NP_345277.1 CDS trmD NC_003028.3 734233 734952 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 734233..734952 Streptococcus pneumoniae TIGR4 930729 YP_873928.1 CDS SP_0780 NC_003028.3 734964 735302 D ATP cone domain-containing protein 734964..735302 Streptococcus pneumoniae TIGR4 930730 NP_345278.1 CDS SP_0781 NC_003028.3 735333 735653 R hypothetical protein complement(735333..735653) Streptococcus pneumoniae TIGR4 930731 NP_345279.1 CDS SP_0782 NC_003028.3 735727 735966 D hypothetical protein 735727..735966 Streptococcus pneumoniae TIGR4 930732 NP_345280.1 CDS SP_0783 NC_003028.3 736172 736708 R hypothetical protein complement(736172..736708) Streptococcus pneumoniae TIGR4 930733 NP_345281.1 CDS SP_0784 NC_003028.3 736905 738251 R catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase complement(736905..738251) Streptococcus pneumoniae TIGR4 930734 NP_345282.1 CDS SP_0785 NC_003028.3 738516 739715 D hypothetical protein 738516..739715 Streptococcus pneumoniae TIGR4 930735 NP_345283.1 CDS SP_0786 NC_003028.3 739699 740400 D ABC transporter ATP-binding protein 739699..740400 Streptococcus pneumoniae TIGR4 930736 NP_345284.1 CDS SP_0787 NC_003028.3 740402 741661 D hypothetical protein 740402..741661 Streptococcus pneumoniae TIGR4 930737 NP_345285.1 CDS metG NC_003028.3 741785 743782 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 741785..743782 Streptococcus pneumoniae TIGR4 930738 NP_345286.1 CDS SP_0789 NC_003028.3 744248 744568 D hypothetical protein 744248..744568 Streptococcus pneumoniae TIGR4 930739 NP_345287.1 CDS SP_0790 NC_003028.3 744572 745387 D hypothetical protein 744572..745387 Streptococcus pneumoniae TIGR4 930740 NP_345288.1 CDS SP_0791 NC_003028.3 745462 746388 D aldo/keto reductase 745462..746388 Streptococcus pneumoniae TIGR4 930741 NP_345289.1 CDS SP_0792 NC_003028.3 746454 746720 D hypothetical protein 746454..746720 Streptococcus pneumoniae TIGR4 930742 NP_345290.1 CDS fabG NC_003028.3 746713 747411 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 746713..747411 Streptococcus pneumoniae TIGR4 930743 NP_345291.1 CDS SP_0794 NC_003028.3 747422 747922 D MutT/nudix family protein 747422..747922 Streptococcus pneumoniae TIGR4 930744 NP_345292.1 CDS SP_0795 NC_003028.3 747975 748769 D hypothetical protein 747975..748769 Streptococcus pneumoniae TIGR4 930745 NP_345293.1 CDS SP_0796 NC_003028.3 748744 749184 D hypothetical protein 748744..749184 Streptococcus pneumoniae TIGR4 930746 NP_345294.1 CDS SP_0797 NC_003028.3 749307 751853 D identified by match to PFAM protein family HMM PF01433; aminopeptidase 749307..751853 Streptococcus pneumoniae TIGR4 930747 NP_345295.1 CDS SP_0798 NC_003028.3 751962 752636 D DNA-binding response regulator CiaR 751962..752636 Streptococcus pneumoniae TIGR4 930748 NP_345296.1 CDS SP_0799 NC_003028.3 752626 753960 D sensor histidine kinase CiaH 752626..753960 Streptococcus pneumoniae TIGR4 930749 NP_345297.1 CDS SP_0800 NC_003028.3 753994 754281 R hypothetical protein complement(753994..754281) Streptococcus pneumoniae TIGR4 930750 NP_345298.1 CDS SP_0801 NC_003028.3 754280 755350 D hypothetical protein 754280..755350 Streptococcus pneumoniae TIGR4 930751 NP_345299.1 CDS SP_0802 NC_003028.3 755550 758000 D unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 755550..758000 Streptococcus pneumoniae TIGR4 930752 NP_345300.1 CDS SP_0803 NC_003028.3 758037 759260 D rod shape-determining protein RodA 758037..759260 Streptococcus pneumoniae TIGR4 930753 NP_345301.1 CDS SP_0804 NC_003028.3 759271 759825 D 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein 759271..759825 Streptococcus pneumoniae TIGR4 930754 NP_345302.1 CDS SP_0805 NC_003028.3 759901 760473 D identified by match to PFAM protein family HMM PF00702; HAD superfamily hydrolase 759901..760473 Streptococcus pneumoniae TIGR4 930755 NP_345303.1 CDS gyrB NC_003028.3 760488 762434 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 760488..762434 Streptococcus pneumoniae TIGR4 930756 NP_345304.1 CDS SP_0807 NC_003028.3 762516 764243 D acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 762516..764243 Streptococcus pneumoniae TIGR4 930757 NP_345305.1 CDS SP_0809 NC_003028.3 764779 764874 D hypothetical protein 764779..764874 Streptococcus pneumoniae TIGR4 930759 NP_345306.1 CDS SP_0810 NC_003028.3 765229 765495 D hypothetical protein 765229..765495 Streptococcus pneumoniae TIGR4 930760 NP_345307.1 CDS SP_0811 NC_003028.3 765527 766036 D transposase 765527..766036 Streptococcus pneumoniae TIGR4 930761 NP_345308.1 CDS SP_0815 NC_003028.3 768130 768243 D hypothetical protein 768130..768243 Streptococcus pneumoniae TIGR4 930765 NP_345309.1 CDS SP_0816 NC_003028.3 768201 768500 R hypothetical protein complement(768201..768500) Streptococcus pneumoniae TIGR4 930766 NP_345310.1 CDS SP_0817 NC_003028.3 768665 769087 R MutT/nudix family protein complement(768665..769087) Streptococcus pneumoniae TIGR4 930767 YP_873929.1 CDS SP_0818 NC_003028.3 769180 769530 D Orf1; IS630-Spn1 transposase 769180..769530 Streptococcus pneumoniae TIGR4 930768 NP_345311.1 CDS SP_0819 NC_003028.3 769728 770051 D IS630-Spn1, transposase Orf2 769728..770051 Streptococcus pneumoniae TIGR4 930769 NP_345312.1 CDS SP_0820 NC_003028.3 770258 772516 R identified by match to PFAM protein family HMM PF02151; ATP-dependent Clp protease ATP-binding subunit ClpE complement(770258..772516) Streptococcus pneumoniae TIGR4 930770 NP_345313.1 CDS SP_0821 NC_003028.3 772647 772748 D hypothetical protein 772647..772748 Streptococcus pneumoniae TIGR4 930771 NP_345314.1 CDS SP_0822 NC_003028.3 772745 772975 R hypothetical protein complement(772745..772975) Streptococcus pneumoniae TIGR4 930772 NP_345315.1 CDS SP_0823 NC_003028.3 773159 773848 D amino acid ABC transporter permease 773159..773848 Streptococcus pneumoniae TIGR4 930773 NP_345316.1 CDS SP_0824 NC_003028.3 773848 774582 D amino acid ABC transporter ATP-binding protein 773848..774582 Streptococcus pneumoniae TIGR4 930774 NP_345317.1 CDS SP_0825 NC_003028.3 774761 775618 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 774761..775618 Streptococcus pneumoniae TIGR4 930775 NP_345318.1 CDS SP_0826 NC_003028.3 775756 776577 D hypothetical protein 775756..776577 Streptococcus pneumoniae TIGR4 930776 NP_345319.1 CDS SP_0828 NC_003028.3 777729 778412 D Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 777729..778412 Streptococcus pneumoniae TIGR4 930778 NP_345320.1 CDS SP_0829 NC_003028.3 778426 779637 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 778426..779637 Streptococcus pneumoniae TIGR4 930779 NP_345321.1 CDS SP_0830 NC_003028.3 779639 780181 D hypothetical protein 779639..780181 Streptococcus pneumoniae TIGR4 930780 NP_345322.1 CDS SP_0831 NC_003028.3 780197 781006 D catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 780197..781006 Streptococcus pneumoniae TIGR4 930781 NP_345323.1 CDS SP_0832 NC_003028.3 781470 781640 D hypothetical protein 781470..781640 Streptococcus pneumoniae TIGR4 930782 NP_345324.1 CDS SP_0833 NC_003028.3 781707 782462 D hypothetical protein 781707..782462 Streptococcus pneumoniae TIGR4 930783 NP_345325.1 CDS SP_0834 NC_003028.3 782487 782999 D similar to GP:3309561; identified by sequence similarity; hemolysin-like protein 782487..782999 Streptococcus pneumoniae TIGR4 930784 NP_345326.1 CDS deoD NC_003028.3 783653 784363 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 783653..784363 Streptococcus pneumoniae TIGR4 930785 NP_345327.1 CDS SP_0836 NC_003028.3 784413 785669 R IS1167, transposase complement(784413..785669) Streptococcus pneumoniae TIGR4 930786 NP_345328.1 CDS SP_0837 NC_003028.3 785809 786333 R topology modulation protein complement(785809..786333) Streptococcus pneumoniae TIGR4 930787 NP_345329.1 CDS rpsT NC_003028.3 786386 786622 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(786386..786622) Streptococcus pneumoniae TIGR4 930788 NP_345330.1 CDS SP_0839 NC_003028.3 786690 787610 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(786690..787610) Streptococcus pneumoniae TIGR4 930789 NP_345331.1 CDS SP_0840 NC_003028.3 787800 788036 D hypothetical protein 787800..788036 Streptococcus pneumoniae TIGR4 930790 NP_345332.1 CDS SP_0841 NC_003028.3 788410 789000 D hypothetical protein 788410..789000 Streptococcus pneumoniae TIGR4 930791 NP_345333.1 CDS SP_0842 NC_003028.3 788997 790274 D Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 788997..790274 Streptococcus pneumoniae TIGR4 930792 NP_345334.1 CDS SP_0843 NC_003028.3 790292 790954 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 790292..790954 Streptococcus pneumoniae TIGR4 930793 NP_345335.1 CDS SP_0844 NC_003028.3 790941 791330 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 790941..791330 Streptococcus pneumoniae TIGR4 930794 NP_345336.1 CDS SP_0845 NC_003028.3 791420 792472 D lipoprotein 791420..792472 Streptococcus pneumoniae TIGR4 930795 NP_345337.1 CDS SP_0846 NC_003028.3 792616 794151 D sugar ABC transporter ATP-binding protein 792616..794151 Streptococcus pneumoniae TIGR4 930796 NP_345338.1 CDS SP_0847 NC_003028.3 794144 795202 D sugar ABC transporter permease 794144..795202 Streptococcus pneumoniae TIGR4 930797 NP_345339.1 CDS SP_0848 NC_003028.3 795205 796161 D similar to GB:AL009126; identified by sequence similarity; sugar ABC transporter permease 795205..796161 Streptococcus pneumoniae TIGR4 930798 NP_345340.1 CDS SP_0851 NC_003028.3 797560 798201 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY complement(797560..798201) Streptococcus pneumoniae TIGR4 930801 NP_345341.1 CDS SP_0852 NC_003028.3 798337 800280 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 798337..800280 Streptococcus pneumoniae TIGR4 930802 NP_345342.1 CDS SP_0853 NC_003028.3 800280 800387 D hypothetical protein 800280..800387 Streptococcus pneumoniae TIGR4 930803 NP_345343.1 CDS SP_0854 NC_003028.3 800401 800526 D hypothetical protein 800401..800526 Streptococcus pneumoniae TIGR4 930804 NP_345344.1 CDS SP_0855 NC_003028.3 800700 803171 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 800700..803171 Streptococcus pneumoniae TIGR4 930805 NP_345345.1 CDS SP_0856 NC_003028.3 803303 804325 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 803303..804325 Streptococcus pneumoniae TIGR4 930806 NP_345346.1 CDS SP_0858 NC_003028.3 805150 805839 D similar to GP:6968020; identified by sequence similarity; hypothetical protein 805150..805839 Streptococcus pneumoniae TIGR4 930808 NP_345347.1 CDS SP_0859 NC_003028.3 805836 806759 D hypothetical protein 805836..806759 Streptococcus pneumoniae TIGR4 930809 NP_345348.1 CDS SP_0860 NC_003028.3 806774 807418 D catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 806774..807418 Streptococcus pneumoniae TIGR4 930810 NP_345349.1 CDS SP_0861 NC_003028.3 807586 807816 D hypothetical protein 807586..807816 Streptococcus pneumoniae TIGR4 930811 NP_345350.1 CDS rpsA NC_003028.3 808189 809391 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 808189..809391 Streptococcus pneumoniae TIGR4 930814 NP_345351.1 CDS SP_0864 NC_003028.3 810997 811494 D hypothetical protein 810997..811494 Streptococcus pneumoniae TIGR4 930816 NP_345352.1 CDS SP_0865 NC_003028.3 811494 813149 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 811494..813149 Streptococcus pneumoniae TIGR4 930817 NP_345353.1 CDS SP_0866 NC_003028.3 813177 813371 D hypothetical protein 813177..813371 Streptococcus pneumoniae TIGR4 930818 NP_345354.1 CDS SP_0867 NC_003028.3 813521 814291 D ABC transporter ATP-binding protein 813521..814291 Streptococcus pneumoniae TIGR4 930819 NP_345355.1 CDS SP_0868 NC_003028.3 814319 815581 D hypothetical protein 814319..815581 Streptococcus pneumoniae TIGR4 930820 NP_345356.1 CDS SP_0869 NC_003028.3 815592 816818 D class-V aminotransferase 815592..816818 Streptococcus pneumoniae TIGR4 930821 NP_345357.1 CDS SP_0870 NC_003028.3 816805 817245 D NifU family protein 816805..817245 Streptococcus pneumoniae TIGR4 930822 NP_345358.1 CDS SP_0871 NC_003028.3 817299 818711 D identified by match to PFAM protein family HMM PF01458; intein-containing protein 817299..818711 Streptococcus pneumoniae TIGR4 930823 NP_345359.1 CDS SP_0872 NC_003028.3 818942 820183 R identified by match to PFAM protein family HMM PF00768; D-alanyl-D-alanine carboxypeptidase complement(818942..820183) Streptococcus pneumoniae TIGR4 930824 NP_345360.1 CDS SP_0873 NC_003028.3 820286 821395 D hypothetical protein 820286..821395 Streptococcus pneumoniae TIGR4 930825 NP_345361.1 CDS SP_0874 NC_003028.3 822274 822381 R hypothetical protein complement(822274..822381) Streptococcus pneumoniae TIGR4 930826 NP_345362.1 CDS SP_0875 NC_003028.3 822707 823447 D lactose phosphotransferase system repressor 822707..823447 Streptococcus pneumoniae TIGR4 930828 NP_345363.1 CDS SP_0876 NC_003028.3 823444 824355 D 1-phosphofructokinase 823444..824355 Streptococcus pneumoniae TIGR4 930829 NP_345364.1 CDS SP_0877 NC_003028.3 824352 826304 D PTS system fructose specific transporter subunit IIABC 824352..826304 Streptococcus pneumoniae TIGR4 930830 NP_345365.1 CDS SP_0878 NC_003028.3 826390 828693 D identified by match to PFAM protein family HMM PF01580; SpoE family protein 826390..828693 Streptococcus pneumoniae TIGR4 930831 NP_345366.1 CDS SP_0879 NC_003028.3 828738 829271 R hypothetical protein complement(828738..829271) Streptococcus pneumoniae TIGR4 930832 NP_345367.1 CDS SP_0880 NC_003028.3 829304 830446 D class-V aminotransferase 829304..830446 Streptococcus pneumoniae TIGR4 930833 NP_345368.1 CDS SP_0881 NC_003028.3 830455 831669 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 830455..831669 Streptococcus pneumoniae TIGR4 930834 NP_345369.1 CDS SP_0882 NC_003028.3 831804 832628 D hypothetical protein 831804..832628 Streptococcus pneumoniae TIGR4 930835 NP_345370.1 CDS SP_0883 NC_003028.3 832650 832985 D hypothetical protein 832650..832985 Streptococcus pneumoniae TIGR4 930836 NP_345371.1 CDS SP_0884 NC_003028.3 832982 833389 D hypothetical protein 832982..833389 Streptococcus pneumoniae TIGR4 930837 NP_345372.1 CDS SP_0885 NC_003028.3 833402 834568 D hypothetical protein 833402..834568 Streptococcus pneumoniae TIGR4 930838 NP_345373.1 CDS SP_0886 NC_003028.3 835075 836568 D type I restriction-modification system, M subunit 835075..836568 Streptococcus pneumoniae TIGR4 930839 NP_345374.1 CDS SP_0887 NC_003028.3 836581 837702 D type I restriction-modification system subunit S 836581..837702 Streptococcus pneumoniae TIGR4 930840 NP_345375.1 CDS SP_0888 NC_003028.3 837762 837998 D hypothetical protein 837762..837998 Streptococcus pneumoniae TIGR4 930841 NP_345376.1 CDS SP_0889 NC_003028.3 837995 838408 D hypothetical protein 837995..838408 Streptococcus pneumoniae TIGR4 930842 NP_345377.1 CDS SP_0890 NC_003028.3 838526 839491 D phage integrase family integrase/recombinase 838526..839491 Streptococcus pneumoniae TIGR4 930843 NP_345378.1 CDS SP_0891 NC_003028.3 839436 840095 D type I restriction-modification system subunit S 839436..840095 Streptococcus pneumoniae TIGR4 930844 NP_345379.1 CDS SP_0892 NC_003028.3 840200 843475 D type I restriction-modification system, R subunit 840200..843475 Streptococcus pneumoniae TIGR4 930845 NP_345380.1 CDS SP_0893 NC_003028.3 843981 844451 R similar to GB:M27869 SP:P17893 PID:142450 PID:143401 PID:1303922; identified by sequence similarity; transcriptional repressor complement(843981..844451) Streptococcus pneumoniae TIGR4 930846 NP_345381.1 CDS SP_0894 NC_003028.3 844468 846741 R catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase complement(844468..846741) Streptococcus pneumoniae TIGR4 930847 NP_345382.1 CDS dnaE NC_003028.3 847061 850189 D Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 847061..850189 Streptococcus pneumoniae TIGR4 930848 NP_345383.1 CDS pfkA NC_003028.3 850271 851278 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 850271..851278 Streptococcus pneumoniae TIGR4 930849 NP_345384.1 CDS SP_0897 NC_003028.3 851337 852842 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 851337..852842 Streptococcus pneumoniae TIGR4 930850 NP_345385.1 CDS SP_0899 NC_003028.3 854646 855518 D hypothetical protein 854646..855518 Streptococcus pneumoniae TIGR4 930852 NP_345386.1 CDS SP_0901 NC_003028.3 856151 856462 D hypothetical protein 856151..856462 Streptococcus pneumoniae TIGR4 930854 NP_345387.2 CDS SP_0902 NC_003028.3 856466 857182 D hypothetical protein 856466..857182 Streptococcus pneumoniae TIGR4 930855 NP_345389.1 CDS SP_0904 NC_003028.3 857311 858126 R hypothetical protein complement(857311..858126) Streptococcus pneumoniae TIGR4 930857 NP_345390.1 CDS SP_0905 NC_003028.3 858123 859028 R hypothetical protein complement(858123..859028) Streptococcus pneumoniae TIGR4 930858 NP_345391.1 CDS SP_0906 NC_003028.3 859029 859160 R hypothetical protein complement(859029..859160) Streptococcus pneumoniae TIGR4 930859 NP_345392.1 CDS SP_0907 NC_003028.3 859370 860737 D similar to GP:5823217; identified by sequence similarity; hypothetical protein 859370..860737 Streptococcus pneumoniae TIGR4 930860 NP_345393.1 CDS SP_0908 NC_003028.3 860839 862968 D transcriptional regulator 860839..862968 Streptococcus pneumoniae TIGR4 930861 NP_345394.1 CDS SP_0909 NC_003028.3 862955 863404 D hypothetical protein 862955..863404 Streptococcus pneumoniae TIGR4 930862 NP_345395.1 CDS SP_0910 NC_003028.3 863462 863734 D hypothetical protein 863462..863734 Streptococcus pneumoniae TIGR4 930863 NP_345396.1 CDS SP_0911 NC_003028.3 864088 864279 R hypothetical protein complement(864088..864279) Streptococcus pneumoniae TIGR4 930864 NP_345397.1 CDS SP_0912 NC_003028.3 864707 865465 D ABC transporter ATP-binding protein 864707..865465 Streptococcus pneumoniae TIGR4 930865 NP_345398.1 CDS SP_0913 NC_003028.3 865467 867455 D ABC transporter permease 865467..867455 Streptococcus pneumoniae TIGR4 930866 NP_345399.1 CDS SP_0915 NC_003028.3 868167 869162 R IS1239 transposase complement(868167..869162) Streptococcus pneumoniae TIGR4 930868 NP_345400.1 CDS SP_0916 NC_003028.3 869869 871344 D identified by match to PFAM protein family HMM PF01276; lysine decarboxylase 869869..871344 Streptococcus pneumoniae TIGR4 930869 NP_345401.1 CDS SP_0917 NC_003028.3 871310 872026 R pilin gene inverting-like protein complement(871310..872026) Streptococcus pneumoniae TIGR4 930870 NP_345402.1 CDS SP_0918 NC_003028.3 872282 873142 D catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 872282..873142 Streptococcus pneumoniae TIGR4 930871 NP_345403.1 CDS SP_0919 NC_003028.3 873139 874398 D hypothetical protein 873139..874398 Streptococcus pneumoniae TIGR4 930872 NP_345404.1 CDS SP_0920 NC_003028.3 874398 875525 D similar to GB:D31783 PID:498170; identified by sequence similarity; carboxynorspermidine decarboxylase 874398..875525 Streptococcus pneumoniae TIGR4 930873 NP_345405.1 CDS SP_0921 NC_003028.3 875522 876607 D catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis; agmatine deiminase 875522..876607 Streptococcus pneumoniae TIGR4 930874 NP_345406.1 CDS SP_0922 NC_003028.3 876617 877492 D identified by match to PFAM protein family HMM PF00795; carbon-nitrogen hydrolase 876617..877492 Streptococcus pneumoniae TIGR4 930875 NP_345407.1 CDS SP_0923 NC_003028.3 877673 878482 R Cof family protein complement(877673..878482) Streptococcus pneumoniae TIGR4 930876 NP_345408.1 CDS SP_0924 NC_003028.3 878754 878975 D hypothetical protein 878754..878975 Streptococcus pneumoniae TIGR4 930877 NP_345409.1 CDS SP_0925 NC_003028.3 879029 879700 D hypothetical protein 879029..879700 Streptococcus pneumoniae TIGR4 930878 NP_345410.1 CDS SP_0926 NC_003028.3 879752 879949 R hypothetical protein complement(879752..879949) Streptococcus pneumoniae TIGR4 930879 NP_345411.1 CDS SP_0927 NC_003028.3 879942 880850 D LysR family transcriptional regulator 879942..880850 Streptococcus pneumoniae TIGR4 930880 NP_345412.1 CDS SP_0928 NC_003028.3 880847 881308 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 880847..881308 Streptococcus pneumoniae TIGR4 930881 NP_345413.1 CDS SP_0929 NC_003028.3 881298 882185 D ribosomal large subunit pseudouridine synthase D 881298..882185 Streptococcus pneumoniae TIGR4 930882 NP_345414.1 CDS SP_0930 NC_003028.3 882188 884071 D choline binding protein E 882188..884071 Streptococcus pneumoniae TIGR4 930883 NP_345415.1 CDS SP_0931 NC_003028.3 884172 885281 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 884172..885281 Streptococcus pneumoniae TIGR4 930884 NP_345416.1 CDS proA NC_003028.3 885291 886553 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 885291..886553 Streptococcus pneumoniae TIGR4 930885 NP_345417.1 CDS SP_0933 NC_003028.3 886557 887354 D identified by match to PFAM protein family HMM PF01089; pyrroline-5-carboxylate reductase 886557..887354 Streptococcus pneumoniae TIGR4 930886 NP_345418.1 CDS SP_0934 NC_003028.3 887364 887462 D hypothetical protein 887364..887462 Streptococcus pneumoniae TIGR4 930887 NP_345419.1 CDS tmk NC_003028.3 887470 888108 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 887470..888108 Streptococcus pneumoniae TIGR4 930888 NP_345420.1 CDS SP_0936 NC_003028.3 888105 888995 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 888105..888995 Streptococcus pneumoniae TIGR4 930889 NP_345421.1 CDS SP_0937 NC_003028.3 889035 889352 D in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 889035..889352 Streptococcus pneumoniae TIGR4 930890 NP_345422.1 CDS SP_0938 NC_003028.3 889355 890224 D identified by match to PFAM protein family HMM PF00590; tetrapyrrole methylase 889355..890224 Streptococcus pneumoniae TIGR4 930891 NP_345423.1 CDS SP_0939 NC_003028.3 890451 890969 D hypothetical protein 890451..890969 Streptococcus pneumoniae TIGR4 930892 NP_345424.1 CDS SP_0941 NC_003028.3 891713 892102 R similar to PID:763133; identified by sequence similarity; IS1381 transposase protein B complement(891713..892102) Streptococcus pneumoniae TIGR4 930894 NP_345425.1 CDS SP_0942 NC_003028.3 892119 892517 R similar to PID:763133; identified by sequence similarity; IS1381 transposase protein A complement(892119..892517) Streptococcus pneumoniae TIGR4 930895 NP_345426.1 CDS SP_0943 NC_003028.3 892924 894294 D TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 892924..894294 Streptococcus pneumoniae TIGR4 930896 NP_345427.1 CDS pyrH NC_003028.3 894372 895115 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 894372..895115 Streptococcus pneumoniae TIGR4 930897 NP_345428.1 CDS frr NC_003028.3 895124 895681 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 895124..895681 Streptococcus pneumoniae TIGR4 930898 NP_345429.1 CDS SP_0946 NC_003028.3 895741 896595 D hypothetical protein 895741..896595 Streptococcus pneumoniae TIGR4 930899 NP_345430.1 CDS SP_0947 NC_003028.3 896604 896819 D hypothetical protein 896604..896819 Streptococcus pneumoniae TIGR4 930900 NP_345431.1 CDS SP_0948 NC_003028.3 896905 897873 D similar to SP:P46343 PID:902050 PID:1303821 GB:AL009126; identified by sequence similarity; PhoH family protein 896905..897873 Streptococcus pneumoniae TIGR4 930901 NP_345432.1 CDS SP_0950 NC_003028.3 898939 899439 D acetyltransferase 898939..899439 Streptococcus pneumoniae TIGR4 930903 NP_345433.1 CDS SP_0951 NC_003028.3 899442 899669 D hypothetical protein 899442..899669 Streptococcus pneumoniae TIGR4 930904 NP_345434.1 CDS SP_0953 NC_003028.3 901345 901914 D acetyltransferase 901345..901914 Streptococcus pneumoniae TIGR4 930906 NP_345435.1 CDS SP_0954 NC_003028.3 901982 902632 D competence protein CelA 901982..902632 Streptococcus pneumoniae TIGR4 930907 NP_345436.1 CDS SP_0955 NC_003028.3 902616 904856 D identified by match to TIGR protein family HMM TIGR00361; competence protein CelB 902616..904856 Streptococcus pneumoniae TIGR4 930908 NP_345437.1 CDS SP_0956 NC_003028.3 905035 905223 D hypothetical protein 905035..905223 Streptococcus pneumoniae TIGR4 930910 NP_345438.1 CDS SP_0957 NC_003028.3 905256 905843 D ABC transporter ATP-binding protein 905256..905843 Streptococcus pneumoniae TIGR4 930911 NP_345439.1 CDS SP_0958 NC_003028.3 905847 907031 D hypothetical protein 905847..907031 Streptococcus pneumoniae TIGR4 930912 NP_345440.1 CDS infC NC_003028.3 907315 907872 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 907315..907872 Streptococcus pneumoniae TIGR4 930913 NP_345441.1 CDS rpmI NC_003028.3 907905 908105 D identified by match to TIGR protein family HMM TIGR00001; 50S ribosomal protein L35 907905..908105 Streptococcus pneumoniae TIGR4 931101 NP_345442.1 CDS rplT NC_003028.3 908157 908516 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 908157..908516 Streptococcus pneumoniae TIGR4 931131 NP_345443.1 CDS SP_0962 NC_003028.3 908574 908954 D identified by match to PFAM protein family HMM PF00903; lactoylglutathione lyase 908574..908954 Streptococcus pneumoniae TIGR4 931133 NP_345444.1 CDS SP_0963 NC_003028.3 909252 910004 D responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+); dihydroorotate dehydrogenase electron transfer subunit 909252..910004 Streptococcus pneumoniae TIGR4 931158 NP_345445.1 CDS SP_0964 NC_003028.3 910015 910953 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 910015..910953 Streptococcus pneumoniae TIGR4 931173 NP_345446.1 CDS SP_0965 NC_003028.3 911052 913028 D endo-beta-N-acetylglucosaminidase 911052..913028 Streptococcus pneumoniae TIGR4 931241 NP_345447.1 CDS SP_0966 NC_003028.3 913089 914744 R similar to GP:6175915; identified by sequence similarity; adherence and virulence protein A complement(913089..914744) Streptococcus pneumoniae TIGR4 931286 NP_345448.1 CDS SP_0967 NC_003028.3 914849 915346 D metalloprotease 914849..915346 Streptococcus pneumoniae TIGR4 931314 NP_345449.1 CDS SP_0968 NC_003028.3 915327 915722 D identified by match to PFAM protein family HMM PF01219; diacylglycerol kinase 915327..915722 Streptococcus pneumoniae TIGR4 931321 NP_345450.1 CDS era NC_003028.3 915739 916638 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 915739..916638 Streptococcus pneumoniae TIGR4 931324 NP_345451.1 CDS SP_0970 NC_003028.3 916687 917511 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 916687..917511 Streptococcus pneumoniae TIGR4 931346 NP_345452.1 CDS coaE NC_003028.3 917511 918116 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 917511..918116 Streptococcus pneumoniae TIGR4 931426 NP_345453.1 CDS SP_0972 NC_003028.3 918103 919302 D multi-drug resistance efflux pump 918103..919302 Streptococcus pneumoniae TIGR4 931481 NP_345454.1 CDS rpmG NC_003028.3 919302 919451 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 919302..919451 Streptococcus pneumoniae TIGR4 931486 NP_345455.1 CDS secG NC_003028.3 919491 919724 D preprotein translocase subunit SecG 919491..919724 Streptococcus pneumoniae TIGR4 931487 NP_345456.1 CDS SP_0975 NC_003028.3 919826 922180 D identified by match to PFAM protein family HMM PF00773; VacB/Rnb family exoribonuclease 919826..922180 Streptococcus pneumoniae TIGR4 931488 NP_345457.1 CDS smpB NC_003028.3 922143 922610 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 922143..922610 Streptococcus pneumoniae TIGR4 931489 NP_345458.1 CDS SP_0977 NC_003028.3 922626 923486 D with TehA confers resistance to tellurite; tellurite resistance protein TehB 922626..923486 Streptococcus pneumoniae TIGR4 931490 NP_345459.1 CDS SP_0978 NC_003028.3 923559 924512 D similar to GP:3211759; identified by sequence similarity; competence protein CoiA 923559..924512 Streptococcus pneumoniae TIGR4 931491 NP_345460.1 CDS SP_0979 NC_003028.3 924531 926333 D identified by match to PFAM protein family HMM PF01432; oligoendopeptidase F 924531..926333 Streptococcus pneumoniae TIGR4 931492 NP_345461.1 CDS SP_0980 NC_003028.3 926335 927048 D identified by match to PFAM protein family HMM PF01596; O-methyltransferase 926335..927048 Streptococcus pneumoniae TIGR4 931493 NP_345462.1 CDS prsA NC_003028.3 927115 928056 D cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase protein PrsA 927115..928056 Streptococcus pneumoniae TIGR4 931494 NP_345463.1 CDS SP_0984 NC_003028.3 929276 929896 R phosphoglycerate mutase complement(929276..929896) Streptococcus pneumoniae TIGR4 931497 NP_345464.1 CDS SP_0985 NC_003028.3 929896 930378 R regulatory protein complement(929896..930378) Streptococcus pneumoniae TIGR4 931498 NP_345465.1 CDS SP_0986 NC_003028.3 930378 931220 R hypothetical protein complement(930378..931220) Streptococcus pneumoniae TIGR4 931499 NP_345466.1 CDS SP_0987 NC_003028.3 931315 932115 R hypothetical protein complement(931315..932115) Streptococcus pneumoniae TIGR4 931500 NP_345467.1 CDS glmU NC_003028.3 932259 933638 D forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 932259..933638 Streptococcus pneumoniae TIGR4 931501 NP_345468.1 CDS SP_0989 NC_003028.3 933648 934193 D MutT/nudix family protein 933648..934193 Streptococcus pneumoniae TIGR4 931502 NP_345469.1 CDS SP_0990 NC_003028.3 934172 934519 D hypothetical protein 934172..934519 Streptococcus pneumoniae TIGR4 931503 NP_345470.1 CDS SP_0991 NC_003028.3 934536 935228 D enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 934536..935228 Streptococcus pneumoniae TIGR4 931504 NP_345471.1 CDS SP_0992 NC_003028.3 935305 935796 D hypothetical protein 935305..935796 Streptococcus pneumoniae TIGR4 931505 NP_345472.1 CDS SP_0993 NC_003028.3 935894 936484 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 935894..936484 Streptococcus pneumoniae TIGR4 931506 NP_345473.1 CDS SP_0994 NC_003028.3 936487 938256 D hypothetical protein 936487..938256 Streptococcus pneumoniae TIGR4 931507 YP_873930.1 CDS SP_0995 NC_003028.3 938452 938799 D Orf1; IS630-Spn1 transposase 938452..938799 Streptococcus pneumoniae TIGR4 931508 NP_345474.1 CDS SP_0997 NC_003028.3 939279 939479 D hypothetical protein 939279..939479 Streptococcus pneumoniae TIGR4 931510 NP_345475.1 CDS SP_0998 NC_003028.3 939626 939925 D hypothetical protein 939626..939925 Streptococcus pneumoniae TIGR4 931511 NP_345476.1 CDS SP_0999 NC_003028.3 940156 940863 D similar to GP:6714962; identified by sequence similarity; cytochrome c-type biogenesis protein CcdA 940156..940863 Streptococcus pneumoniae TIGR4 931512 NP_345477.1 CDS SP_1000 NC_003028.3 940874 941431 D thioredoxin 940874..941431 Streptococcus pneumoniae TIGR4 931513 NP_345478.1 CDS SP_1001 NC_003028.3 941805 943196 D identified by match to PFAM protein family HMM PF00324; amino acid permease 941805..943196 Streptococcus pneumoniae TIGR4 931514 NP_345479.1 CDS SP_1002 NC_003028.3 943339 944256 D identified by match to PFAM protein family HMM PF01297; adhesion lipoprotein 943339..944256 Streptococcus pneumoniae TIGR4 931515 NP_345480.1 CDS SP_1003 NC_003028.3 944264 946783 D hypothetical protein 944264..946783 Streptococcus pneumoniae TIGR4 931516 NP_345481.1 CDS SP_1004 NC_003028.3 946993 950112 D hypothetical protein 946993..950112 Streptococcus pneumoniae TIGR4 931517 NP_345482.1 CDS SP_1006 NC_003028.3 951620 951823 R hypothetical protein complement(951620..951823) Streptococcus pneumoniae TIGR4 931519 NP_345483.1 CDS SP_1007 NC_003028.3 951806 952435 D hypothetical protein 951806..952435 Streptococcus pneumoniae TIGR4 931520 NP_345484.1 CDS SP_1008 NC_003028.3 952471 953694 R catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T complement(952471..953694) Streptococcus pneumoniae TIGR4 931521 NP_345485.1 CDS SP_1009 NC_003028.3 953849 954943 D identified by match to TIGR protein family HMM TIGR00109; ferrochelatase 953849..954943 Streptococcus pneumoniae TIGR4 931522 NP_345486.1 CDS SP_1010 NC_003028.3 954985 955362 R identified by match to PFAM protein family HMM PF01741; large conductance mechanosensitive channel protein MscL complement(954985..955362) Streptococcus pneumoniae TIGR4 931523 NP_345487.1 CDS SP_1011 NC_003028.3 955444 955875 R similar to GB:X73124 SP:P39602 PID:413958 GB:AL009126; identified by sequence similarity; GtrA family protein complement(955444..955875) Streptococcus pneumoniae TIGR4 931524 NP_345488.1 CDS SP_1012 NC_003028.3 955998 956507 D hypothetical protein 955998..956507 Streptococcus pneumoniae TIGR4 931525 NP_345489.1 CDS SP_1013 NC_003028.3 957021 958097 D catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 957021..958097 Streptococcus pneumoniae TIGR4 931527 NP_345490.1 CDS dapA NC_003028.3 958153 959088 D catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 958153..959088 Streptococcus pneumoniae TIGR4 931528 NP_345491.1 CDS trmE NC_003028.3 960558 961931 R in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE complement(960558..961931) Streptococcus pneumoniae TIGR4 931530 NP_345492.1 CDS SP_1017 NC_003028.3 962068 962250 R 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase complement(962068..962250) Streptococcus pneumoniae TIGR4 931531 NP_345493.1 CDS SP_1018 NC_003028.3 962374 962973 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 962374..962973 Streptococcus pneumoniae TIGR4 931532 NP_345494.1 CDS SP_1019 NC_003028.3 962963 963442 D acetyltransferase 962963..963442 Streptococcus pneumoniae TIGR4 931533 NP_345495.1 CDS prfA NC_003028.3 963452 964531 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 963452..964531 Streptococcus pneumoniae TIGR4 931534 NP_345496.1 CDS SP_1021 NC_003028.3 964531 965370 D HemK protein 964531..965370 Streptococcus pneumoniae TIGR4 931535 NP_345497.1 CDS SP_1022 NC_003028.3 965357 965956 D identified by match to PFAM protein family HMM PF01300; Sua5/YciO/YrdC family protein 965357..965956 Streptococcus pneumoniae TIGR4 931536 NP_345498.1 CDS SP_1023 NC_003028.3 965958 966389 D acetyltransferase 965958..966389 Streptococcus pneumoniae TIGR4 931537 NP_345499.1 CDS glyA NC_003028.3 966451 967707 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 966451..967707 Streptococcus pneumoniae TIGR4 931538 NP_345500.1 CDS SP_1025 NC_003028.3 967682 968689 D hypothetical protein 967682..968689 Streptococcus pneumoniae TIGR4 931539 NP_345501.1 CDS SP_1026 NC_003028.3 968689 969303 D hypothetical protein 968689..969303 Streptococcus pneumoniae TIGR4 931540 NP_345502.1 CDS SP_1027 NC_003028.3 969377 970351 D hypothetical protein 969377..970351 Streptococcus pneumoniae TIGR4 931541 NP_345503.1 CDS SP_1028 NC_003028.3 970320 970412 D hypothetical protein 970320..970412 Streptococcus pneumoniae TIGR4 931542 NP_345504.1 CDS SP_1029 NC_003028.3 970425 972056 D RNA methyltransferase 970425..972056 Streptococcus pneumoniae TIGR4 931543 NP_345505.1 CDS SP_1030 NC_003028.3 972795 973013 D hypothetical protein 972795..973013 Streptococcus pneumoniae TIGR4 931544 NP_345506.1 CDS SP_1031 NC_003028.3 973184 973285 D hypothetical protein 973184..973285 Streptococcus pneumoniae TIGR4 931545 NP_345507.1 CDS SP_1032 NC_003028.3 973406 974431 D iron-compound ABC transporter iron compound-binding protein 973406..974431 Streptococcus pneumoniae TIGR4 931546 NP_345508.1 CDS SP_1033 NC_003028.3 974409 975428 D identified by match to PFAM protein family HMM PF01032; iron ABC transporter permease 974409..975428 Streptococcus pneumoniae TIGR4 931547 NP_345509.1 CDS SP_1034 NC_003028.3 975428 976435 D identified by match to PFAM protein family HMM PF01032; iron ABC transporter permease 975428..976435 Streptococcus pneumoniae TIGR4 931548 NP_345510.1 CDS SP_1035 NC_003028.3 976435 977229 D iron-compound ABC transporter ATP-binding protein 976435..977229 Streptococcus pneumoniae TIGR4 931549 NP_345511.1 CDS SP_1036 NC_003028.3 977345 977437 R hypothetical protein complement(977345..977437) Streptococcus pneumoniae TIGR4 931550 NP_345512.1 CDS SP_1037 NC_003028.3 977797 978006 D similar to GB:L17341 SP:Q07606 PID:304141; identified by sequence similarity; type II restriction endonuclease 977797..978006 Streptococcus pneumoniae TIGR4 931551 NP_345513.1 CDS SP_1038 NC_003028.3 978131 978286 D hypothetical protein 978131..978286 Streptococcus pneumoniae TIGR4 931552 NP_345514.1 CDS SP_1039 NC_003028.3 978970 979131 D hypothetical protein 978970..979131 Streptococcus pneumoniae TIGR4 931553 NP_345515.1 CDS SP_1040 NC_003028.3 979223 980902 D resolvase family site-specific recombinase 979223..980902 Streptococcus pneumoniae TIGR4 931554 NP_345516.1 CDS SP_1041 NC_003028.3 981125 981736 D hypothetical protein 981125..981736 Streptococcus pneumoniae TIGR4 931555 NP_345517.1 CDS SP_1042 NC_003028.3 982049 982246 D hypothetical protein 982049..982246 Streptococcus pneumoniae TIGR4 931556 NP_345518.1 CDS SP_1043 NC_003028.3 982308 983066 D hypothetical protein 982308..983066 Streptococcus pneumoniae TIGR4 931557 NP_345519.1 CDS SP_1044 NC_003028.3 983124 983978 D similar to GP:7020551; identified by sequence similarity; hydrolase 983124..983978 Streptococcus pneumoniae TIGR4 931558 NP_345520.1 CDS SP_1045 NC_003028.3 984090 984974 D hypothetical protein 984090..984974 Streptococcus pneumoniae TIGR4 931559 NP_345521.1 CDS SP_1047 NC_003028.3 986963 987280 D hypothetical protein 986963..987280 Streptococcus pneumoniae TIGR4 931561 NP_345522.1 CDS SP_1048 NC_003028.3 987326 987607 D hypothetical protein 987326..987607 Streptococcus pneumoniae TIGR4 931562 NP_345523.1 CDS SP_1049 NC_003028.3 987747 987860 D hypothetical protein 987747..987860 Streptococcus pneumoniae TIGR4 931563 NP_345524.1 CDS SP_1050 NC_003028.3 988052 988528 D transcriptional regulator 988052..988528 Streptococcus pneumoniae TIGR4 931564 NP_345525.1 CDS SP_1051 NC_003028.3 988528 989289 D hypothetical protein 988528..989289 Streptococcus pneumoniae TIGR4 931565 NP_345526.1 CDS SP_1052 NC_003028.3 989317 990093 D identified by match to PFAM protein family HMM PF02231; hypothetical protein 989317..990093 Streptococcus pneumoniae TIGR4 931566 NP_345527.1 CDS SP_1053 NC_003028.3 990096 990473 D similar to GP:6009450; identified by sequence similarity; hypothetical protein 990096..990473 Streptococcus pneumoniae TIGR4 931567 NP_345528.1 CDS SP_1054 NC_003028.3 991304 991660 D similar to PID:951053; identified by sequence similarity; Tn5252, ORF 10 protein 991304..991660 Streptococcus pneumoniae TIGR4 931568 NP_345529.1 CDS SP_1055 NC_003028.3 991665 992030 D similar to PID:951052; identified by sequence similarity; Tn5252, ORF 9 protein 991665..992030 Streptococcus pneumoniae TIGR4 931569 NP_345530.1 CDS SP_1056 NC_003028.3 992017 993840 D Tn5252, relaxase 992017..993840 Streptococcus pneumoniae TIGR4 931570 NP_345531.1 CDS SP_1057 NC_003028.3 993954 994820 D transcriptional regulator PlcR 993954..994820 Streptococcus pneumoniae TIGR4 931571 NP_345532.1 CDS SP_1058 NC_003028.3 994973 995107 D hypothetical protein 994973..995107 Streptococcus pneumoniae TIGR4 931572 NP_345533.1 CDS SP_1059 NC_003028.3 995411 995662 D hypothetical protein 995411..995662 Streptococcus pneumoniae TIGR4 931573 NP_345534.1 CDS SP_1060 NC_003028.3 995882 996193 D hypothetical protein 995882..996193 Streptococcus pneumoniae TIGR4 931574 NP_345535.1 CDS SP_1061 NC_003028.3 996190 997536 D protein kinase 996190..997536 Streptococcus pneumoniae TIGR4 931575 NP_345536.1 CDS SP_1062 NC_003028.3 997550 998467 D ABC transporter ATP-binding protein 997550..998467 Streptococcus pneumoniae TIGR4 931576 NP_345537.1 CDS SP_1063 NC_003028.3 998464 999264 D ABC transporter permease 998464..999264 Streptococcus pneumoniae TIGR4 931577 NP_345538.1 CDS SP_1064 NC_003028.3 999422 999895 D IS200 family transposase 999422..999895 Streptococcus pneumoniae TIGR4 931578 NP_345539.1 CDS SP_1065 NC_003028.3 1000385 1000606 R hypothetical protein complement(1000385..1000606) Streptococcus pneumoniae TIGR4 931579 NP_345540.1 CDS SP_1067 NC_003028.3 1001278 1002507 D cell division protein FtsW 1001278..1002507 Streptococcus pneumoniae TIGR4 931581 NP_345541.1 CDS SP_1068 NC_003028.3 1002527 1005223 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 1002527..1005223 Streptococcus pneumoniae TIGR4 931582 NP_345542.1 CDS SP_1069 NC_003028.3 1005606 1006640 D hypothetical protein 1005606..1006640 Streptococcus pneumoniae TIGR4 931583 NP_345543.1 CDS SP_1070 NC_003028.3 1006709 1007575 D hypothetical protein 1006709..1007575 Streptococcus pneumoniae TIGR4 931584 NP_345544.1 CDS SP_1071 NC_003028.3 1007572 1008330 D ABC transporter ATP-binding protein 1007572..1008330 Streptococcus pneumoniae TIGR4 931585 NP_345545.1 CDS dnaG NC_003028.3 1008420 1010180 D synthesizes RNA primers at the replication forks; DNA primase 1008420..1010180 Streptococcus pneumoniae TIGR4 931586 NP_345546.1 CDS SP_1073 NC_003028.3 1010183 1011292 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 1010183..1011292 Streptococcus pneumoniae TIGR4 931587 NP_345547.1 CDS SP_1074 NC_003028.3 1011306 1011635 D hypothetical protein 1011306..1011635 Streptococcus pneumoniae TIGR4 931588 NP_345548.1 CDS SP_1075 NC_003028.3 1011777 1012793 D glycosyl transferase CpoA 1011777..1012793 Streptococcus pneumoniae TIGR4 931589 NP_345549.1 CDS SP_1076 NC_003028.3 1012809 1014134 D group 1 glycosyl transferase 1012809..1014134 Streptococcus pneumoniae TIGR4 931590 NP_345550.1 CDS SP_1077 NC_003028.3 1014165 1014341 D similar to GB:AL009126; identified by sequence similarity; hypothetical protein 1014165..1014341 Streptococcus pneumoniae TIGR4 931591 NP_345551.1 CDS SP_1078 NC_003028.3 1014400 1014534 D hypothetical protein 1014400..1014534 Streptococcus pneumoniae TIGR4 931592 NP_345552.1 CDS obgE NC_003028.3 1014604 1015908 D essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1014604..1015908 Streptococcus pneumoniae TIGR4 931593 NP_345553.1 CDS SP_1080 NC_003028.3 1015918 1016076 D hypothetical protein 1015918..1016076 Streptococcus pneumoniae TIGR4 931594 NP_345554.1 CDS SP_1081 NC_003028.3 1017219 1018478 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1017219..1018478 Streptococcus pneumoniae TIGR4 931595 NP_345555.1 CDS SP_1082 NC_003028.3 1018494 1019045 D acetyltransferase 1018494..1019045 Streptococcus pneumoniae TIGR4 931596 NP_345556.1 CDS SP_1083 NC_003028.3 1019038 1020315 D hypothetical protein 1019038..1020315 Streptococcus pneumoniae TIGR4 931597 NP_345557.1 CDS SP_1084 NC_003028.3 1020331 1021191 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 1020331..1021191 Streptococcus pneumoniae TIGR4 931598 NP_345558.1 CDS SP_1086 NC_003028.3 1021985 1022374 D similar to PID:763133; identified by sequence similarity; IS1381 transposase protein B 1021985..1022374 Streptococcus pneumoniae TIGR4 931600 NP_345559.1 CDS SP_1087 NC_003028.3 1022565 1024856 D ATP-dependent DNA helicase PcrA 1022565..1024856 Streptococcus pneumoniae TIGR4 931601 NP_345560.1 CDS radC NC_003028.3 1024899 1025579 D Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 1024899..1025579 Streptococcus pneumoniae TIGR4 931602 NP_345561.1 CDS SP_1089 NC_003028.3 1025576 1026265 R glutamine amidotransferase complement(1025576..1026265) Streptococcus pneumoniae TIGR4 931603 NP_345562.1 CDS SP_1090 NC_003028.3 1026283 1026924 R modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex complement(1026283..1026924) Streptococcus pneumoniae TIGR4 931604 NP_345563.1 CDS SP_1091 NC_003028.3 1026940 1027032 R hypothetical protein complement(1026940..1027032) Streptococcus pneumoniae TIGR4 931605 NP_345564.1 CDS SP_1092 NC_003028.3 1027007 1027258 R hypothetical protein complement(1027007..1027258) Streptococcus pneumoniae TIGR4 931606 NP_345565.1 CDS SP_1093 NC_003028.3 1027230 1027577 R hypothetical protein complement(1027230..1027577) Streptococcus pneumoniae TIGR4 931607 NP_345566.1 CDS SP_1094 NC_003028.3 1027582 1028664 R class-V aminotransferase complement(1027582..1028664) Streptococcus pneumoniae TIGR4 931608 NP_345567.1 CDS SP_1095 NC_003028.3 1028707 1029666 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1028707..1029666) Streptococcus pneumoniae TIGR4 931609 NP_345568.1 CDS SP_1096 NC_003028.3 1029779 1030348 R hypothetical protein complement(1029779..1030348) Streptococcus pneumoniae TIGR4 931610 NP_345569.1 CDS SP_1097 NC_003028.3 1030476 1031147 D hypothetical protein 1030476..1031147 Streptococcus pneumoniae TIGR4 931611 NP_345570.1 CDS ppnK NC_003028.3 1031131 1031949 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1031131..1031949 Streptococcus pneumoniae TIGR4 931612 NP_345571.1 CDS SP_1099 NC_003028.3 1031946 1032842 D ribosomal large subunit pseudouridine synthase D 1031946..1032842 Streptococcus pneumoniae TIGR4 931613 NP_345572.1 CDS eutD NC_003028.3 1032886 1033860 D in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 1032886..1033860 Streptococcus pneumoniae TIGR4 931614 NP_345573.1 CDS SP_1102 NC_003028.3 1035629 1035919 R hypothetical protein complement(1035629..1035919) Streptococcus pneumoniae TIGR4 931616 NP_345574.1 CDS SP_1103 NC_003028.3 1035925 1036032 R hypothetical protein complement(1035925..1036032) Streptococcus pneumoniae TIGR4 931617 NP_345575.1 CDS SP_1104 NC_003028.3 1036330 1037034 D hypothetical protein 1036330..1037034 Streptococcus pneumoniae TIGR4 931618 NP_345576.1 CDS rplU NC_003028.3 1037216 1037530 D identified by match to TIGR protein family HMM TIGR00061; 50S ribosomal protein L21 1037216..1037530 Streptococcus pneumoniae TIGR4 931619 NP_345577.1 CDS SP_1106 NC_003028.3 1037546 1037890 D hypothetical protein 1037546..1037890 Streptococcus pneumoniae TIGR4 931620 NP_345578.1 CDS rpmA NC_003028.3 1037916 1038200 D involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1037916..1038200 Streptococcus pneumoniae TIGR4 931621 NP_345579.1 CDS SP_1108 NC_003028.3 1038546 1038716 R hypothetical protein complement(1038546..1038716) Streptococcus pneumoniae TIGR4 931622 NP_345580.1 CDS SP_1109 NC_003028.3 1038688 1038807 R hypothetical protein complement(1038688..1038807) Streptococcus pneumoniae TIGR4 931623 NP_345581.1 CDS SP_1110 NC_003028.3 1039154 1040071 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1039154..1040071 Streptococcus pneumoniae TIGR4 931624 NP_345582.1 CDS SP_1111 NC_003028.3 1040164 1041012 R hypothetical protein complement(1040164..1041012) Streptococcus pneumoniae TIGR4 931625 NP_345583.1 CDS SP_1112 NC_003028.3 1041154 1041993 D degV family protein 1041154..1041993 Streptococcus pneumoniae TIGR4 931626 NP_345584.1 CDS SP_1113 NC_003028.3 1042099 1042374 D DNA-binding protein HU 1042099..1042374 Streptococcus pneumoniae TIGR4 931627 NP_345585.1 CDS SP_1114 NC_003028.3 1042800 1044701 D ABC transporter ATP-binding protein 1042800..1044701 Streptococcus pneumoniae TIGR4 931628 NP_345586.1 CDS SP_1115 NC_003028.3 1044704 1045567 D transcriptional regulator MutR 1044704..1045567 Streptococcus pneumoniae TIGR4 931629 NP_345587.1 CDS SP_1116 NC_003028.3 1045647 1046825 D transporter 1045647..1046825 Streptococcus pneumoniae TIGR4 931630 NP_345588.1 CDS ligA NC_003028.3 1046918 1048876 D this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1046918..1048876 Streptococcus pneumoniae TIGR4 931631 NP_345589.1 CDS SP_1118 NC_003028.3 1048988 1051267 D pullulanase 1048988..1051267 Streptococcus pneumoniae TIGR4 931632 NP_345590.1 CDS SP_1119 NC_003028.3 1051812 1053236 D glyceraldehyde-3-phosphate dehydrogenase 1051812..1053236 Streptococcus pneumoniae TIGR4 931633 NP_345591.1 CDS SP_1120 NC_003028.3 1053585 1053689 R hypothetical protein complement(1053585..1053689) Streptococcus pneumoniae TIGR4 931634 NP_345592.1 CDS SP_1121 NC_003028.3 1053719 1055647 D catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 1053719..1055647 Streptococcus pneumoniae TIGR4 931635 NP_345593.1 CDS glgC NC_003028.3 1055637 1056779 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1055637..1056779 Streptococcus pneumoniae TIGR4 931636 NP_345594.1 CDS SP_1123 NC_003028.3 1056769 1057908 D glycogen biosynthesis protein GlgD 1056769..1057908 Streptococcus pneumoniae TIGR4 931637 NP_345595.1 CDS glgA NC_003028.3 1057905 1059338 D catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 1057905..1059338 Streptococcus pneumoniae TIGR4 931638 NP_345596.1 CDS SP_1126 NC_003028.3 1060051 1061166 D hypothetical protein 1060051..1061166 Streptococcus pneumoniae TIGR4 931640 NP_345597.1 CDS SP_1127 NC_003028.3 1061163 1061609 R hypothetical protein complement(1061163..1061609) Streptococcus pneumoniae TIGR4 931641 NP_345598.1 CDS eno NC_003028.3 1061773 1063077 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1061773..1063077 Streptococcus pneumoniae TIGR4 931642 NP_345599.1 CDS SP_1129 NC_003028.3 1063231 1064394 R phage integrase family integrase/recombinase complement(1063231..1064394) Streptococcus pneumoniae TIGR4 931643 NP_345600.1 CDS SP_1130 NC_003028.3 1064469 1065317 R transcriptional regulator complement(1064469..1065317) Streptococcus pneumoniae TIGR4 931644 NP_345601.1 CDS SP_1131 NC_003028.3 1065437 1065790 D transcriptional regulator 1065437..1065790 Streptococcus pneumoniae TIGR4 931645 NP_345602.1 CDS SP_1132 NC_003028.3 1065890 1066156 D hypothetical protein 1065890..1066156 Streptococcus pneumoniae TIGR4 931646 NP_345603.1 CDS SP_1133 NC_003028.3 1066167 1066319 D hypothetical protein 1066167..1066319 Streptococcus pneumoniae TIGR4 931647 NP_345604.1 CDS SP_1134 NC_003028.3 1066524 1067141 D hypothetical protein 1066524..1067141 Streptococcus pneumoniae TIGR4 931648 NP_345605.1 CDS SP_1135 NC_003028.3 1067176 1067628 D hypothetical protein 1067176..1067628 Streptococcus pneumoniae TIGR4 931649 NP_345606.1 CDS SP_1136 NC_003028.3 1067625 1068071 D similar to GP:1813342; identified by sequence similarity; hypothetical protein 1067625..1068071 Streptococcus pneumoniae TIGR4 931650 NP_345607.1 CDS SP_1137 NC_003028.3 1068083 1068967 D identified by match to PFAM protein family HMM PF01695; GTP-binding protein 1068083..1068967 Streptococcus pneumoniae TIGR4 931651 NP_345608.1 CDS SP_1138 NC_003028.3 1068980 1069090 R hypothetical protein complement(1068980..1069090) Streptococcus pneumoniae TIGR4 931652 NP_345609.1 CDS SP_1139 NC_003028.3 1069216 1069866 D hypothetical protein 1069216..1069866 Streptococcus pneumoniae TIGR4 931653 NP_345610.1 CDS SP_1140 NC_003028.3 1069913 1070341 D hypothetical protein 1069913..1070341 Streptococcus pneumoniae TIGR4 931654 NP_345611.1 CDS SP_1141 NC_003028.3 1070349 1070660 D hypothetical protein 1070349..1070660 Streptococcus pneumoniae TIGR4 931655 NP_345612.1 CDS SP_1142 NC_003028.3 1070678 1071088 D hypothetical protein 1070678..1071088 Streptococcus pneumoniae TIGR4 931656 NP_345613.1 CDS SP_1143 NC_003028.3 1071285 1071650 D hypothetical protein 1071285..1071650 Streptococcus pneumoniae TIGR4 931657 NP_345614.1 CDS SP_1144 NC_003028.3 1071640 1071933 D hypothetical protein 1071640..1071933 Streptococcus pneumoniae TIGR4 931658 NP_345615.1 CDS SP_1145 NC_003028.3 1071951 1073141 D hypothetical protein 1071951..1073141 Streptococcus pneumoniae TIGR4 931659 NP_345616.1 CDS SP_1146 NC_003028.3 1073144 1073320 D hypothetical protein 1073144..1073320 Streptococcus pneumoniae TIGR4 931660 NP_345617.1 CDS SP_1148 NC_003028.3 1073986 1074324 R IS630-Spn1, transposase Orf2 complement(1073986..1074324) Streptococcus pneumoniae TIGR4 931662 NP_345618.1 CDS SP_1149 NC_003028.3 1074433 1074849 R IS630-Spn1, transposase Orf1 complement(1074433..1074849) Streptococcus pneumoniae TIGR4 931663 NP_345619.1 CDS SP_1150 NC_003028.3 1075245 1075346 R hypothetical protein complement(1075245..1075346) Streptococcus pneumoniae TIGR4 931664 NP_345620.1 CDS SP_1151 NC_003028.3 1075357 1078632 D exonuclease RexB 1075357..1078632 Streptococcus pneumoniae TIGR4 931665 NP_345621.1 CDS SP_1152 NC_003028.3 1078629 1082279 D exonuclease RexA 1078629..1082279 Streptococcus pneumoniae TIGR4 931666 NP_345622.1 CDS SP_1153 NC_003028.3 1082494 1083672 D hypothetical protein 1082494..1083672 Streptococcus pneumoniae TIGR4 931667 NP_345623.1 CDS SP_1154 NC_003028.3 1083881 1089895 D identified by match to PFAM protein family HMM PF00746; immunoglobulin A1 protease 1083881..1089895 Streptococcus pneumoniae TIGR4 931668 NP_345624.1 CDS rbgA NC_003028.3 1090342 1091193 D essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1090342..1091193 Streptococcus pneumoniae TIGR4 931669 NP_345625.1 CDS rnhB NC_003028.3 1091180 1091959 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1091180..1091959 Streptococcus pneumoniae TIGR4 931670 NP_345626.1 CDS SP_1157 NC_003028.3 1091975 1093525 D identified by match to PFAM protein family HMM PF00654; voltage-gated chloride channel family protein 1091975..1093525 Streptococcus pneumoniae TIGR4 931671 NP_345627.1 CDS SP_1158 NC_003028.3 1093718 1093831 R hypothetical protein complement(1093718..1093831) Streptococcus pneumoniae TIGR4 931672 NP_345628.1 CDS xerS NC_003028.3 1094109 1095179 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1094109..1095179 Streptococcus pneumoniae TIGR4 931673 NP_345629.1 CDS SP_1160 NC_003028.3 1095244 1096233 R lipoate-protein ligase complement(1095244..1096233) Streptococcus pneumoniae TIGR4 931674 NP_345630.1 CDS SP_1161 NC_003028.3 1096297 1098000 R acetoin dehydrogenase complex, E3 component, dihydrolipoamide dehydrogenase complement(1096297..1098000) Streptococcus pneumoniae TIGR4 931675 NP_345631.1 CDS SP_1162 NC_003028.3 1098046 1099089 R unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain; dihydrolipoamide acetyltransferase complement(1098046..1099089) Streptococcus pneumoniae TIGR4 931676 NP_345632.1 CDS SP_1163 NC_003028.3 1099307 1100299 R acetoin dehydrogenase, E1 component subunit beta complement(1099307..1100299) Streptococcus pneumoniae TIGR4 931677 NP_345633.1 CDS SP_1164 NC_003028.3 1100315 1101283 R identified by match to PFAM protein family HMM PF00676; acetoin dehydrogenase, E1 component subunit alpha complement(1100315..1101283) Streptococcus pneumoniae TIGR4 931678 NP_345634.1 CDS SP_1165 NC_003028.3 1101330 1101440 D hypothetical protein 1101330..1101440 Streptococcus pneumoniae TIGR4 931679 NP_345635.1 CDS SP_1166 NC_003028.3 1101437 1102798 R identified by match to PFAM protein family HMM PF01554; MATE efflux family protein complement(1101437..1102798) Streptococcus pneumoniae TIGR4 931680 NP_345636.1 CDS pyrC NC_003028.3 1103083 1104351 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1103083..1104351) Streptococcus pneumoniae TIGR4 931681 NP_345637.1 CDS SP_1168 NC_003028.3 1104364 1104828 R mutator MutT protein complement(1104364..1104828) Streptococcus pneumoniae TIGR4 931682 NP_345638.1 CDS SP_1169 NC_003028.3 1104838 1105491 R Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase complement(1104838..1105491) Streptococcus pneumoniae TIGR4 931683 NP_345639.1 CDS SP_1170 NC_003028.3 1105629 1106231 R hypothetical protein complement(1105629..1106231) Streptococcus pneumoniae TIGR4 931684 NP_345640.1 CDS SP_1171 NC_003028.3 1106289 1107002 R identified by match to PFAM protein family HMM PF00702; HAD superfamily hydrolase complement(1106289..1107002) Streptococcus pneumoniae TIGR4 931685 NP_345641.1 CDS SP_1172 NC_003028.3 1107253 1107372 R hypothetical protein complement(1107253..1107372) Streptococcus pneumoniae TIGR4 931686 NP_345642.1 CDS SP_1173 NC_003028.3 1107462 1107836 R PTS system mannnose-specific transporter subunit IIA complement(1107462..1107836) Streptococcus pneumoniae TIGR4 931687 NP_345643.1 CDS SP_1174 NC_003028.3 1108258 1110717 R similar to GP:4249624; identified by sequence similarity; hypothetical protein complement(1108258..1110717) Streptococcus pneumoniae TIGR4 931688 NP_345644.1 CDS SP_1175 NC_003028.3 1110875 1113283 R similar to GP:4249624; identified by sequence similarity; hypothetical protein complement(1110875..1113283) Streptococcus pneumoniae TIGR4 931689 NP_345645.1 CDS SP_1176 NC_003028.3 1113578 1115311 R phosphoenolpyruvate-protein phosphotransferase complement(1113578..1115311) Streptococcus pneumoniae TIGR4 931690 NP_345646.1 CDS SP_1177 NC_003028.3 1115317 1115580 R phosphocarrier protein HPr complement(1115317..1115580) Streptococcus pneumoniae TIGR4 931691 NP_345647.1 CDS SP_1178 NC_003028.3 1115931 1116149 D NrdH-redoxin 1115931..1116149 Streptococcus pneumoniae TIGR4 931692 NP_345648.1 CDS SP_1179 NC_003028.3 1116230 1118389 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1116230..1118389 Streptococcus pneumoniae TIGR4 931693 NP_345649.1 CDS nrdF NC_003028.3 1118577 1119539 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1118577..1119539 Streptococcus pneumoniae TIGR4 931694 NP_345650.1 CDS SP_1181 NC_003028.3 1119754 1119852 R hypothetical protein complement(1119754..1119852) Streptococcus pneumoniae TIGR4 931695 NP_345651.1 CDS SP_1182 NC_003028.3 1119827 1120588 D lactose phosphotransferase system repressor 1119827..1120588 Streptococcus pneumoniae TIGR4 931696 NP_345652.1 CDS SP_1183 NC_003028.3 1120867 1121031 R hypothetical protein complement(1120867..1121031) Streptococcus pneumoniae TIGR4 931697 NP_345653.1 CDS SP_1184 NC_003028.3 1121169 1122575 R catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase complement(1121169..1122575) Streptococcus pneumoniae TIGR4 931698 NP_345654.1 CDS SP_1185 NC_003028.3 1122784 1124475 R PTS system lactose-specific transporter subunit IIBC complement(1122784..1124475) Streptococcus pneumoniae TIGR4 931699 NP_345655.1 CDS SP_1186 NC_003028.3 1124475 1124792 R identified by match to PFAM protein family HMM PF02255; PTS system lactose-specific transporter subunit IIA complement(1124475..1124792) Streptococcus pneumoniae TIGR4 931700 NP_345656.1 CDS SP_1187 NC_003028.3 1124828 1125664 R identified by match to PFAM protein family HMM PF00874; transcription antiterminator LacT complement(1124828..1125664) Streptococcus pneumoniae TIGR4 931701 NP_345657.1 CDS SP_1188 NC_003028.3 1125902 1126048 R hypothetical protein complement(1125902..1126048) Streptococcus pneumoniae TIGR4 931702 NP_345658.1 CDS SP_1189 NC_003028.3 1126062 1126604 R hypothetical protein complement(1126062..1126604) Streptococcus pneumoniae TIGR4 931703 NP_345659.1 CDS SP_1190 NC_003028.3 1126937 1127917 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase complement(1126937..1127917) Streptococcus pneumoniae TIGR4 931704 NP_345660.1 CDS SP_1191 NC_003028.3 1127919 1128848 R catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase complement(1127919..1128848) Streptococcus pneumoniae TIGR4 931705 NP_345661.1 CDS SP_1192 NC_003028.3 1128859 1129374 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB complement(1128859..1129374) Streptococcus pneumoniae TIGR4 931706 NP_345662.1 CDS SP_1193 NC_003028.3 1129405 1129830 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA complement(1129405..1129830) Streptococcus pneumoniae TIGR4 931707 NP_345663.1 CDS SP_1195 NC_003028.3 1130500 1130889 R similar to PID:763133; identified by sequence similarity; IS1381 transposase protein B complement(1130500..1130889) Streptococcus pneumoniae TIGR4 931709 NP_345664.1 CDS SP_1197 NC_003028.3 1131313 1131615 R hypothetical protein complement(1131313..1131615) Streptococcus pneumoniae TIGR4 931711 NP_345665.1 CDS SP_1198 NC_003028.3 1131653 1131925 R hypothetical protein complement(1131653..1131925) Streptococcus pneumoniae TIGR4 931712 NP_345666.1 CDS SP_1199 NC_003028.3 1131925 1132041 R hypothetical protein complement(1131925..1132041) Streptococcus pneumoniae TIGR4 931713 NP_345667.1 CDS SP_1200 NC_003028.3 1132584 1134407 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(1132584..1134407) Streptococcus pneumoniae TIGR4 931714 NP_345668.1 CDS SP_1201 NC_003028.3 1134486 1135214 R serine/threonine protein phosphatase complement(1134486..1135214) Streptococcus pneumoniae TIGR4 931715 NP_345669.1 CDS SP_1202 NC_003028.3 1135216 1136883 R identified by match to TIGR protein family HMM TIGR00634; DNA repair protein RecN complement(1135216..1136883) Streptococcus pneumoniae TIGR4 931716 NP_345670.1 CDS SP_1203 NC_003028.3 1136890 1137321 R transcriptional repressor complement(1136890..1137321) Streptococcus pneumoniae TIGR4 931717 NP_345671.1 CDS SP_1204 NC_003028.3 1137314 1137910 R similar to GB:M27869 SP:P19672 PID:142449 GB:AL009126; identified by sequence similarity; hemolysin A complement(1137314..1137910) Streptococcus pneumoniae TIGR4 931718 NP_345672.1 CDS SP_1205 NC_003028.3 1138122 1138997 R identified by match to PFAM protein family HMM PF00348; geranyltranstransferase complement(1138122..1138997) Streptococcus pneumoniae TIGR4 931719 NP_345673.1 CDS xseB NC_003028.3 1138994 1139206 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(1138994..1139206) Streptococcus pneumoniae TIGR4 931720 NP_345674.1 CDS xseA NC_003028.3 1139184 1140524 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(1139184..1140524) Streptococcus pneumoniae TIGR4 931721 NP_345675.1 CDS SP_1208 NC_003028.3 1140652 1141290 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(1140652..1141290) Streptococcus pneumoniae TIGR4 931722 NP_345676.1 CDS SP_1209 NC_003028.3 1141285 1141401 D hypothetical protein 1141285..1141401 Streptococcus pneumoniae TIGR4 931723 NP_345677.1 CDS SP_1210 NC_003028.3 1141398 1141565 R hypothetical protein complement(1141398..1141565) Streptococcus pneumoniae TIGR4 931724 NP_345678.1 CDS SP_1211 NC_003028.3 1141697 1141792 R hypothetical protein complement(1141697..1141792) Streptococcus pneumoniae TIGR4 931725 NP_345679.1 CDS truB NC_003028.3 1141941 1142819 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(1141941..1142819) Streptococcus pneumoniae TIGR4 931726 NP_345680.1 CDS SP_1213 NC_003028.3 1142829 1144103 R similar to GP:6899348; identified by sequence similarity; hypothetical protein complement(1142829..1144103) Streptococcus pneumoniae TIGR4 931727 NP_345681.1 CDS SP_1215 NC_003028.3 1145606 1146403 R FNT family protein complement(1145606..1146403) Streptococcus pneumoniae TIGR4 931729 NP_345682.1 CDS SP_1216 NC_003028.3 1146372 1146479 R hypothetical protein complement(1146372..1146479) Streptococcus pneumoniae TIGR4 931730 NP_345683.1 CDS SP_1217 NC_003028.3 1146532 1146675 D hypothetical protein 1146532..1146675 Streptococcus pneumoniae TIGR4 931731 NP_345684.1 CDS SP_1218 NC_003028.3 1146647 1147018 R hypothetical protein complement(1146647..1147018) Streptococcus pneumoniae TIGR4 931732 NP_345685.1 CDS SP_1219 NC_003028.3 1147390 1149858 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(1147390..1149858) Streptococcus pneumoniae TIGR4 931733 NP_345686.1 CDS ldh NC_003028.3 1150052 1151038 D Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1150052..1151038 Streptococcus pneumoniae TIGR4 931734 NP_345687.1 CDS SP_1221 NC_003028.3 1151348 1154602 R similar to GP:4467889; identified by sequence similarity; type II restriction endonuclease complement(1151348..1154602) Streptococcus pneumoniae TIGR4 931735 NP_345688.1 CDS SP_1222 NC_003028.3 1154767 1156644 R similar to GP:4467889; identified by sequence similarity; type II restriction endonuclease complement(1154767..1156644) Streptococcus pneumoniae TIGR4 931736 NP_345689.1 CDS SP_1223 NC_003028.3 1156713 1156967 R hypothetical protein complement(1156713..1156967) Streptococcus pneumoniae TIGR4 931737 NP_345690.1 CDS SP_1224 NC_003028.3 1156969 1157271 R similar to GP:7523564; identified by sequence similarity; hypothetical protein complement(1156969..1157271) Streptococcus pneumoniae TIGR4 931738 NP_345691.1 CDS SP_1225 NC_003028.3 1157302 1158111 R vicX protein complement(1157302..1158111) Streptococcus pneumoniae TIGR4 931739 NP_345692.1 CDS SP_1226 NC_003028.3 1158113 1159462 R sensory box sensor histidine kinase complement(1158113..1159462) Streptococcus pneumoniae TIGR4 931740 NP_345693.1 CDS SP_1227 NC_003028.3 1159455 1160159 R DNA-binding response regulator complement(1159455..1160159) Streptococcus pneumoniae TIGR4 931741 NP_345694.1 CDS SP_1228 NC_003028.3 1160215 1161360 R A/G-specific adenine glycosylase complement(1160215..1161360) Streptococcus pneumoniae TIGR4 931742 NP_345695.1 CDS SP_1229 NC_003028.3 1161718 1163388 R catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase complement(1161718..1163388) Streptococcus pneumoniae TIGR4 931743 NP_345696.1 CDS SP_1230 NC_003028.3 1163618 1164307 D phosphopantothenate--cysteine ligase 1163618..1164307 Streptococcus pneumoniae TIGR4 931744 NP_345697.1 CDS SP_1231 NC_003028.3 1164319 1164870 D decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 1164319..1164870 Streptococcus pneumoniae TIGR4 931745 NP_345698.1 CDS SP_1232 NC_003028.3 1164854 1165417 D hypothetical protein 1164854..1165417 Streptococcus pneumoniae TIGR4 931746 NP_345699.1 CDS SP_1233 NC_003028.3 1165645 1166226 D hypothetical protein 1165645..1166226 Streptococcus pneumoniae TIGR4 931747 NP_345700.1 CDS SP_1234 NC_003028.3 1166238 1166753 D similar to GB:AE000512; identified by sequence similarity; biotin repressor family transcriptional regulator 1166238..1166753 Streptococcus pneumoniae TIGR4 931748 NP_345701.1 CDS SP_1235 NC_003028.3 1166750 1167217 R MutT/nudix family protein complement(1166750..1167217) Streptococcus pneumoniae TIGR4 931749 NP_345702.1 CDS SP_1236 NC_003028.3 1167286 1167774 R acetyltransferase complement(1167286..1167774) Streptococcus pneumoniae TIGR4 931750 NP_345703.1 CDS SP_1237 NC_003028.3 1167740 1168303 R acetyltransferase complement(1167740..1168303) Streptococcus pneumoniae TIGR4 931751 NP_345704.1 CDS SP_1238 NC_003028.3 1168313 1170301 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B complement(1168313..1170301) Streptococcus pneumoniae TIGR4 931752 NP_345705.1 CDS SP_1240 NC_003028.3 1170378 1171331 R hypothetical protein complement(1170378..1171331) Streptococcus pneumoniae TIGR4 931753 NP_345706.1 CDS SP_1241 NC_003028.3 1171501 1173666 D amino acid ABC transporter amino acid-binding protein/permease 1171501..1173666 Streptococcus pneumoniae TIGR4 931754 NP_345707.1 CDS SP_1242 NC_003028.3 1173666 1174406 D amino acid ABC transporter ATP-binding protein 1173666..1174406 Streptococcus pneumoniae TIGR4 931755 NP_345708.1 CDS SP_1243 NC_003028.3 1174555 1176042 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1174555..1176042 Streptococcus pneumoniae TIGR4 931756 NP_345709.1 CDS SP_1244 NC_003028.3 1176088 1177377 R identified by match to PFAM protein family HMM PF00448; signal recognition particle-docking protein FtsY complement(1176088..1177377) Streptococcus pneumoniae TIGR4 931757 NP_345710.1 CDS SP_1245 NC_003028.3 1177381 1178199 R Cof family protein complement(1177381..1178199) Streptococcus pneumoniae TIGR4 931758 NP_345711.1 CDS SP_1246 NC_003028.3 1178199 1178993 R Cof family protein complement(1178199..1178993) Streptococcus pneumoniae TIGR4 931759 NP_345712.1 CDS SP_1247 NC_003028.3 1178990 1182529 R hypothetical protein complement(1178990..1182529) Streptococcus pneumoniae TIGR4 931760 NP_345713.1 CDS rnc NC_003028.3 1182520 1183218 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(1182520..1183218) Streptococcus pneumoniae TIGR4 931761 NP_345714.1 CDS SP_1249 NC_003028.3 1183536 1184522 R guanosine 5'-monophosphate oxidoreductase complement(1183536..1184522) Streptococcus pneumoniae TIGR4 931763 NP_345715.1 CDS SP_1250 NC_003028.3 1184697 1186025 R similar to GP:6967634; identified by sequence similarity; hypothetical protein complement(1184697..1186025) Streptococcus pneumoniae TIGR4 931764 NP_345716.1 CDS SP_1251 NC_003028.3 1186000 1187931 R endonuclease complement(1186000..1187931) Streptococcus pneumoniae TIGR4 931765 NP_345717.1 CDS SP_1252 NC_003028.3 1188095 1188265 R hypothetical protein complement(1188095..1188265) Streptococcus pneumoniae TIGR4 931766 NP_345718.1 CDS SP_1253 NC_003028.3 1188265 1188357 R hypothetical protein complement(1188265..1188357) Streptococcus pneumoniae TIGR4 931767 NP_345719.1 CDS SP_1254 NC_003028.3 1188517 1188660 R hypothetical protein complement(1188517..1188660) Streptococcus pneumoniae TIGR4 931768 NP_345720.1 CDS SP_1255 NC_003028.3 1188879 1189238 R hypothetical protein complement(1188879..1189238) Streptococcus pneumoniae TIGR4 931769 NP_345721.1 CDS SP_1256 NC_003028.3 1189242 1189511 R hypothetical protein complement(1189242..1189511) Streptococcus pneumoniae TIGR4 931770 NP_345722.1 CDS SP_1258 NC_003028.3 1190557 1191651 R 2-isopropylmalate synthase complement(1190557..1191651) Streptococcus pneumoniae TIGR4 931772 NP_345723.1 CDS SP_1259 NC_003028.3 1191670 1192005 R hypothetical protein complement(1191670..1192005) Streptococcus pneumoniae TIGR4 931773 NP_345724.1 CDS SP_1260 NC_003028.3 1192370 1193002 R similar to GP:1736520; identified by sequence similarity; copper homeostasis protein CutC complement(1192370..1193002) Streptococcus pneumoniae TIGR4 931774 NP_345725.1 CDS SP_1261 NC_003028.3 1193095 1193454 R hypothetical protein complement(1193095..1193454) Streptococcus pneumoniae TIGR4 931775 NP_345726.1 CDS SP_1262 NC_003028.3 1193814 1195070 D IS1167, transposase 1193814..1195070 Streptococcus pneumoniae TIGR4 931776 NP_345727.1 CDS SP_1263 NC_003028.3 1195085 1197184 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(1195085..1197184) Streptococcus pneumoniae TIGR4 931777 NP_345728.1 CDS SP_1264 NC_003028.3 1197351 1198394 R hypothetical protein complement(1197351..1198394) Streptococcus pneumoniae TIGR4 931778 NP_345729.1 CDS SP_1265 NC_003028.3 1198653 1198772 R hypothetical protein complement(1198653..1198772) Streptococcus pneumoniae TIGR4 931779 NP_345730.1 CDS SP_1266 NC_003028.3 1199284 1200144 R DNA processing protein DprA complement(1199284..1200144) Streptococcus pneumoniae TIGR4 931780 NP_345731.1 CDS SP_1267 NC_003028.3 1200228 1200917 R licC protein complement(1200228..1200917) Streptococcus pneumoniae TIGR4 931781 NP_345732.1 CDS SP_1268 NC_003028.3 1200929 1201807 R licB protein complement(1200929..1201807) Streptococcus pneumoniae TIGR4 931782 NP_345733.1 CDS SP_1269 NC_003028.3 1201797 1202585 R choline kinase complement(1201797..1202585) Streptococcus pneumoniae TIGR4 931783 NP_345734.1 CDS SP_1270 NC_003028.3 1202683 1203705 R zinc-containing alcohol dehydrogenase complement(1202683..1203705) Streptococcus pneumoniae TIGR4 931784 NP_345735.1 CDS ispD NC_003028.3 1203710 1204417 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(1203710..1204417) Streptococcus pneumoniae TIGR4 931785 NP_345736.1 CDS SP_1272 NC_003028.3 1204753 1206240 D polysaccharide biosynthesis protein 1204753..1206240 Streptococcus pneumoniae TIGR4 931786 NP_345737.1 CDS SP_1273 NC_003028.3 1206250 1207053 D similar to GP:5001692; identified by sequence similarity; licD1 protein 1206250..1207053 Streptococcus pneumoniae TIGR4 931787 NP_345738.1 CDS SP_1274 NC_003028.3 1207055 1207864 D similar to GP:5001693; identified by sequence similarity; licD2 protein 1207055..1207864 Streptococcus pneumoniae TIGR4 931788 NP_345739.1 CDS carB NC_003028.3 1208139 1211315 R four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit complement(1208139..1211315) Streptococcus pneumoniae TIGR4 931789 NP_345740.1 CDS SP_1276 NC_003028.3 1211628 1212707 R catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit complement(1211628..1212707) Streptococcus pneumoniae TIGR4 931790 NP_345741.1 CDS pyrB NC_003028.3 1212757 1213680 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase complement(1212757..1213680) Streptococcus pneumoniae TIGR4 931791 NP_345742.1 CDS SP_1278 NC_003028.3 1213699 1214220 R regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase complement(1213699..1214220) Streptococcus pneumoniae TIGR4 931792 NP_345743.1 CDS SP_1279 NC_003028.3 1214431 1215060 R endonuclease III complement(1214431..1215060) Streptococcus pneumoniae TIGR4 931793 NP_345744.1 CDS SP_1280 NC_003028.3 1215060 1215602 R hypothetical protein complement(1215060..1215602) Streptococcus pneumoniae TIGR4 931794 NP_345745.1 CDS SP_1281 NC_003028.3 1215724 1216089 D hypothetical protein 1215724..1216089 Streptococcus pneumoniae TIGR4 931795 NP_345746.1 CDS SP_1282 NC_003028.3 1216328 1217887 D ABC transporter ATP-binding protein 1216328..1217887 Streptococcus pneumoniae TIGR4 931796 NP_345747.1 CDS SP_1283 NC_003028.3 1217931 1218830 R metalloprotease; heat shock protein HtpX complement(1217931..1218830) Streptococcus pneumoniae TIGR4 931797 NP_345748.1 CDS SP_1284 NC_003028.3 1218832 1219392 R similar to PID:1519287; identified by sequence similarity; hypothetical protein complement(1218832..1219392) Streptococcus pneumoniae TIGR4 931798 NP_345749.1 CDS gidB NC_003028.3 1219486 1220199 D glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1219486..1220199 Streptococcus pneumoniae TIGR4 931799 NP_345750.1 CDS SP_1286 NC_003028.3 1220466 1221785 D uracil permease 1220466..1221785 Streptococcus pneumoniae TIGR4 931800 NP_345751.1 CDS SP_1287 NC_003028.3 1221980 1223551 R identified by match to PFAM protein family HMM PF00448; signal recognition particle protein complement(1221980..1223551) Streptococcus pneumoniae TIGR4 931801 NP_345752.1 CDS SP_1288 NC_003028.3 1223563 1223895 R DNA-binding protein complement(1223563..1223895) Streptococcus pneumoniae TIGR4 931802 NP_345753.1 CDS SP_1289 NC_003028.3 1223986 1224363 R hypothetical protein complement(1223986..1224363) Streptococcus pneumoniae TIGR4 931803 NP_345754.1 CDS SP_1290 NC_003028.3 1224435 1225739 D hypothetical protein 1224435..1225739 Streptococcus pneumoniae TIGR4 931804 NP_345755.1 CDS SP_1291 NC_003028.3 1225752 1226558 D Cof family protein 1225752..1226558 Streptococcus pneumoniae TIGR4 931805 NP_345756.1 CDS SP_1292 NC_003028.3 1226601 1227599 D SAP domain-containing protein 1226601..1227599 Streptococcus pneumoniae TIGR4 931806 NP_345757.1 CDS rplS NC_003028.3 1227880 1228227 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(1227880..1228227) Streptococcus pneumoniae TIGR4 931808 NP_345758.1 CDS SP_1294 NC_003028.3 1228346 1228675 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1228346..1228675) Streptococcus pneumoniae TIGR4 931809 NP_345759.1 CDS SP_1295 NC_003028.3 1228669 1229043 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1228669..1229043) Streptococcus pneumoniae TIGR4 931810 NP_345760.1 CDS SP_1296 NC_003028.3 1229040 1229306 R identified by match to PFAM protein family HMM PF01817; hypothetical protein complement(1229040..1229306) Streptococcus pneumoniae TIGR4 931811 NP_345761.1 CDS SP_1297 NC_003028.3 1229422 1229865 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(1229422..1229865) Streptococcus pneumoniae TIGR4 931812 NP_345762.1 CDS SP_1298 NC_003028.3 1229969 1230904 D identified by match to PFAM protein family HMM PF02272; DHH subfamily 1 protein 1229969..1230904 Streptococcus pneumoniae TIGR4 931813 NP_345763.1 CDS rpmE2 NC_003028.3 1231000 1231242 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1231000..1231242 Streptococcus pneumoniae TIGR4 931814 NP_345764.1 CDS SP_1300 NC_003028.3 1231299 1231517 R hypothetical protein complement(1231299..1231517) Streptococcus pneumoniae TIGR4 931815 NP_345765.1 CDS SP_1302 NC_003028.3 1231825 1232076 R hypothetical protein complement(1231825..1232076) Streptococcus pneumoniae TIGR4 931817 NP_345766.1 CDS SP_1303 NC_003028.3 1232170 1232265 R hypothetical protein complement(1232170..1232265) Streptococcus pneumoniae TIGR4 931818 NP_345767.1 CDS SP_1304 NC_003028.3 1232390 1232491 R hypothetical protein complement(1232390..1232491) Streptococcus pneumoniae TIGR4 931819 NP_345768.1 CDS SP_1305 NC_003028.3 1232501 1232605 D hypothetical protein 1232501..1232605 Streptococcus pneumoniae TIGR4 931820 NP_345769.1 CDS SP_1306 NC_003028.3 1232602 1233948 D converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1232602..1233948 Streptococcus pneumoniae TIGR4 931821 NP_345770.1 CDS SP_1307 NC_003028.3 1234454 1234624 R hypothetical protein complement(1234454..1234624) Streptococcus pneumoniae TIGR4 931822 NP_345771.1 CDS SP_1310 NC_003028.3 1235637 1236035 R similar to PID:763133; identified by sequence similarity; IS1381 transposase protein A complement(1235637..1236035) Streptococcus pneumoniae TIGR4 931825 NP_345772.1 CDS SP_1314 NC_003028.3 1238079 1238318 R similar to GP:4009479; identified by sequence similarity; IS66 family Orf1 complement(1238079..1238318) Streptococcus pneumoniae TIGR4 931829 NP_345773.1 CDS SP_1315 NC_003028.3 1238537 1239148 R produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit D complement(1238537..1239148) Streptococcus pneumoniae TIGR4 931830 NP_345774.1 CDS SP_1316 NC_003028.3 1239171 1240556 R produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit B complement(1239171..1240556) Streptococcus pneumoniae TIGR4 931831 NP_345775.1 CDS SP_1317 NC_003028.3 1240557 1242332 R produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit A complement(1240557..1242332) Streptococcus pneumoniae TIGR4 931832 NP_345776.1 CDS SP_1318 NC_003028.3 1242395 1242715 R produces ATP from ADP in the presence of a proton gradient across the membrane; the F subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit F complement(1242395..1242715) Streptococcus pneumoniae TIGR4 931833 NP_345777.1 CDS SP_1319 NC_003028.3 1242705 1243712 R v-type sodium ATP synthase subunit C complement(1242705..1243712) Streptococcus pneumoniae TIGR4 931835 NP_345778.1 CDS SP_1320 NC_003028.3 1243777 1244358 R v-type sodium ATP synthase subunit E complement(1243777..1244358) Streptococcus pneumoniae TIGR4 931836 NP_345779.1 CDS SP_1321 NC_003028.3 1244392 1244868 R produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits; V-type ATP synthase subunit K complement(1244392..1244868) Streptococcus pneumoniae TIGR4 931837 NP_345780.1 CDS SP_1322 NC_003028.3 1244884 1246875 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I is part of the membrane proton channel.; V-type ATP synthase subunit I complement(1244884..1246875) Streptococcus pneumoniae TIGR4 931838 NP_345781.1 CDS SP_1323 NC_003028.3 1246865 1247188 R hypothetical protein complement(1246865..1247188) Streptococcus pneumoniae TIGR4 931839 NP_345782.1 CDS SP_1324 NC_003028.3 1247213 1248103 R ROK family protein complement(1247213..1248103) Streptococcus pneumoniae TIGR4 931840 NP_345783.1 CDS SP_1325 NC_003028.3 1248260 1249399 R Gfo/Idh/MocA family oxidoreductase complement(1248260..1249399) Streptococcus pneumoniae TIGR4 931841 NP_345784.1 CDS SP_1326 NC_003028.3 1249409 1251631 R neuraminidase complement(1249409..1251631) Streptococcus pneumoniae TIGR4 931842 NP_345785.1 CDS SP_1327 NC_003028.3 1251633 1252091 R hypothetical protein complement(1251633..1252091) Streptococcus pneumoniae TIGR4 931843 NP_345786.1 CDS SP_1328 NC_003028.3 1252110 1253651 R identified by match to PFAM protein family HMM PF00474; sodium:solute symporter family protein complement(1252110..1253651) Streptococcus pneumoniae TIGR4 931845 NP_345787.1 CDS SP_1329 NC_003028.3 1253679 1254596 R identified by match to PFAM protein family HMM PF00701; N-acetylneuraminate lyase complement(1253679..1254596) Streptococcus pneumoniae TIGR4 931846 NP_345788.1 CDS SP_1330 NC_003028.3 1254621 1255322 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(1254621..1255322) Streptococcus pneumoniae TIGR4 931847 NP_345789.1 CDS SP_1331 NC_003028.3 1255327 1256136 R phosphosugar-binding transcriptional regulator complement(1255327..1256136) Streptococcus pneumoniae TIGR4 931848 NP_345790.1 CDS SP_1332 NC_003028.3 1256535 1257122 R similar to GB:AL123456; identified by sequence similarity; hypothetical protein complement(1256535..1257122) Streptococcus pneumoniae TIGR4 931849 NP_345791.1 CDS SP_1333 NC_003028.3 1257125 1257358 R hypothetical protein complement(1257125..1257358) Streptococcus pneumoniae TIGR4 931850 NP_345792.1 CDS SP_1334 NC_003028.3 1257371 1257751 R hypothetical protein complement(1257371..1257751) Streptococcus pneumoniae TIGR4 931851 NP_345793.1 CDS SP_1335 NC_003028.3 1257909 1258097 R hypothetical protein complement(1257909..1258097) Streptococcus pneumoniae TIGR4 931852 NP_345794.1 CDS SP_1336 NC_003028.3 1258315 1259538 R type II DNA modification methyltransferase Spn5252IP complement(1258315..1259538) Streptococcus pneumoniae TIGR4 931853 NP_345795.1 CDS SP_1337 NC_003028.3 1259720 1261066 R similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase complement(1259720..1261066) Streptococcus pneumoniae TIGR4 931854 NP_345796.1 CDS SP_1338 NC_003028.3 1261328 1261507 R hypothetical protein complement(1261328..1261507) Streptococcus pneumoniae TIGR4 931855 NP_345797.1 CDS SP_1339 NC_003028.3 1261687 1261824 R hypothetical protein complement(1261687..1261824) Streptococcus pneumoniae TIGR4 931856 NP_345798.1 CDS SP_1340 NC_003028.3 1261957 1263276 R hypothetical protein complement(1261957..1263276) Streptococcus pneumoniae TIGR4 931857 NP_345799.1 CDS SP_1341 NC_003028.3 1263279 1264019 R ABC transporter ATP-binding protein complement(1263279..1264019) Streptococcus pneumoniae TIGR4 931858 NP_345800.1 CDS SP_1342 NC_003028.3 1264034 1265641 R drug efflux ABC transporter ATP-binding protein/permease complement(1264034..1265641) Streptococcus pneumoniae TIGR4 931859 NP_345801.1 CDS SP_1343 NC_003028.3 1265638 1267578 R identified by match to PFAM protein family HMM PF00326; prolyl oligopeptidase complement(1265638..1267578) Streptococcus pneumoniae TIGR4 931860 NP_345802.1 CDS SP_1344 NC_003028.3 1267611 1270220 R hypothetical protein complement(1267611..1270220) Streptococcus pneumoniae TIGR4 931861 NP_345803.1 CDS SP_1345 NC_003028.3 1270383 1270493 R hypothetical protein complement(1270383..1270493) Streptococcus pneumoniae TIGR4 931862 NP_345804.1 CDS SP_1346 NC_003028.3 1270738 1271325 R hypothetical protein complement(1270738..1271325) Streptococcus pneumoniae TIGR4 931863 NP_345805.1 CDS SP_1347 NC_003028.3 1271418 1271561 R hypothetical protein complement(1271418..1271561) Streptococcus pneumoniae TIGR4 931864 NP_345806.1 CDS SP_1348 NC_003028.3 1271574 1271954 R hypothetical protein complement(1271574..1271954) Streptococcus pneumoniae TIGR4 931865 NP_345807.1 CDS SP_1349 NC_003028.3 1272009 1272287 R hypothetical protein complement(1272009..1272287) Streptococcus pneumoniae TIGR4 931866 NP_345808.1 CDS SP_1350 NC_003028.3 1272295 1272549 R similar to GP:5257160; identified by sequence similarity; hypothetical protein complement(1272295..1272549) Streptococcus pneumoniae TIGR4 931867 NP_345809.1 CDS SP_1351 NC_003028.3 1272549 1272656 R hypothetical protein complement(1272549..1272656) Streptococcus pneumoniae TIGR4 931868 NP_345810.1 CDS SP_1352 NC_003028.3 1272838 1274184 R similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase complement(1272838..1274184) Streptococcus pneumoniae TIGR4 931869 NP_345811.1 CDS SP_1353 NC_003028.3 1274488 1274595 R hypothetical protein complement(1274488..1274595) Streptococcus pneumoniae TIGR4 931870 NP_345812.1 CDS rplL NC_003028.3 1274614 1274982 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(1274614..1274982) Streptococcus pneumoniae TIGR4 929737 NP_345813.1 CDS rplJ NC_003028.3 1275058 1275558 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(1275058..1275558) Streptococcus pneumoniae TIGR4 931471 NP_345814.3 CDS SP_1356 NC_003028.3 1275807 1277066 R identified by match to PFAM protein family HMM PF01685; chlorohydrolase complement(1275807..1277066) Streptococcus pneumoniae TIGR4 929816 NP_345815.1 CDS SP_1357 NC_003028.3 1277458 1279248 R ABC transporter ATP-binding protein/permease complement(1277458..1279248) Streptococcus pneumoniae TIGR4 931878 NP_345816.1 CDS SP_1358 NC_003028.3 1279211 1280935 R ABC transporter ATP-binding protein/permease complement(1279211..1280935) Streptococcus pneumoniae TIGR4 930077 NP_345817.1 CDS SP_1359 NC_003028.3 1280993 1281931 R this fusion consists of methionine sulfoxide A reductase at the N-terminus and B at the C-terminus; A and B are stereospecific enzymes that recognize the damaged produces of oxidative stress, S and R epimers of methionine sulfoxide, respectively; a fusion; bifunctional methionine sulfoxide reductase A/B complement(1280993..1281931) Streptococcus pneumoniae TIGR4 931912 NP_345818.1 CDS SP_1360 NC_003028.3 1282226 1283095 R catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase complement(1282226..1283095) Streptococcus pneumoniae TIGR4 931412 NP_345819.1 CDS SP_1361 NC_003028.3 1283097 1284383 R catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase complement(1283097..1284383) Streptococcus pneumoniae TIGR4 931415 NP_345820.1 CDS SP_1362 NC_003028.3 1284534 1285271 R enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein complement(1284534..1285271) Streptococcus pneumoniae TIGR4 931453 NP_345821.1 CDS SP_1363 NC_003028.3 1285471 1286505 R similar to GB:AL009126; identified by sequence similarity; hypothetical protein complement(1285471..1286505) Streptococcus pneumoniae TIGR4 931472 NP_345822.1 CDS SP_1364 NC_003028.3 1286534 1287967 R hypothetical protein complement(1286534..1287967) Streptococcus pneumoniae TIGR4 931470 NP_345823.1 CDS SP_1365 NC_003028.3 1287983 1288969 R glycosyl transferase family protein complement(1287983..1288969) Streptococcus pneumoniae TIGR4 931469 NP_345824.1 CDS SP_1366 NC_003028.3 1288971 1290074 R group 1 glycosyl transferase complement(1288971..1290074) Streptococcus pneumoniae TIGR4 931468 NP_345825.1 CDS SP_1367 NC_003028.3 1290064 1290909 R similar to GB:L42023 PID:1007735 PID:1221686 PID:1205775 PID:1574382; identified by sequence similarity; licD3 protein complement(1290064..1290909) Streptococcus pneumoniae TIGR4 931467 NP_345826.1 CDS SP_1368 NC_003028.3 1291188 1292462 R psr protein complement(1291188..1292462) Streptococcus pneumoniae TIGR4 931466 NP_345827.1 CDS SP_1369 NC_003028.3 1292459 1293307 R catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase complement(1292459..1293307) Streptococcus pneumoniae TIGR4 931465 NP_345828.1 CDS SP_1370 NC_003028.3 1293304 1293780 R shikimate kinase complement(1293304..1293780) Streptococcus pneumoniae TIGR4 931464 NP_345829.1 CDS SP_1371 NC_003028.3 1293773 1295056 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(1293773..1295056) Streptococcus pneumoniae TIGR4 931459 NP_345830.1 CDS SP_1372 NC_003028.3 1295148 1295486 R hypothetical protein complement(1295148..1295486) Streptococcus pneumoniae TIGR4 931460 NP_345831.1 CDS SP_1373 NC_003028.3 1295497 1296600 R catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase complement(1295497..1296600) Streptococcus pneumoniae TIGR4 931462 NP_345832.1 CDS SP_1374 NC_003028.3 1296610 1297776 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(1296610..1297776) Streptococcus pneumoniae TIGR4 931463 NP_345833.1 CDS aroB NC_003028.3 1297786 1298853 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(1297786..1298853) Streptococcus pneumoniae TIGR4 931458 NP_345834.1 CDS aroE NC_003028.3 1298872 1299726 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(1298872..1299726) Streptococcus pneumoniae TIGR4 931461 NP_345835.1 CDS aroD NC_003028.3 1299716 1300393 R catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase complement(1299716..1300393) Streptococcus pneumoniae TIGR4 931457 NP_345836.1 CDS SP_1378 NC_003028.3 1300390 1301562 R hypothetical protein complement(1300390..1301562) Streptococcus pneumoniae TIGR4 931450 NP_345837.1 CDS SP_1379 NC_003028.3 1301604 1301750 D hypothetical protein 1301604..1301750 Streptococcus pneumoniae TIGR4 931451 NP_345838.1 CDS SP_1380 NC_003028.3 1302240 1303901 R hypothetical protein complement(1302240..1303901) Streptococcus pneumoniae TIGR4 931452 NP_345839.1 CDS SP_1381 NC_003028.3 1303855 1304604 R ABC transporter ATP-binding protein complement(1303855..1304604) Streptococcus pneumoniae TIGR4 931454 NP_345840.1 CDS SP_1382 NC_003028.3 1304783 1306237 D converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 1304783..1306237 Streptococcus pneumoniae TIGR4 931456 NP_345841.1 CDS alaS NC_003028.3 1306327 1308945 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(1306327..1308945) Streptococcus pneumoniae TIGR4 931455 NP_345842.1 CDS SP_1384 NC_003028.3 1308967 1309464 R hypothetical protein complement(1308967..1309464) Streptococcus pneumoniae TIGR4 931484 NP_345843.1 CDS SP_1385 NC_003028.3 1309727 1309966 R hypothetical protein complement(1309727..1309966) Streptococcus pneumoniae TIGR4 931485 NP_345844.1 CDS SP_1386 NC_003028.3 1310219 1311289 R spermidine/putrescine ABC transporter spermidine/putrescine-binding protein complement(1310219..1311289) Streptococcus pneumoniae TIGR4 931448 NP_345845.1 CDS SP_1387 NC_003028.3 1311286 1312059 R spermidine/putrescine ABC transporter permease complement(1311286..1312059) Streptococcus pneumoniae TIGR4 931449 NP_345846.1 CDS SP_1388 NC_003028.3 1312056 1312883 R spermidine/putrescine ABC transporter permease complement(1312056..1312883) Streptococcus pneumoniae TIGR4 931436 NP_345847.1 CDS SP_1389 NC_003028.3 1312843 1314000 R spermidine/putrescine ABC transporter ATP-binding protein complement(1312843..1314000) Streptococcus pneumoniae TIGR4 931437 NP_345848.1 CDS murB NC_003028.3 1314059 1315009 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(1314059..1315009) Streptococcus pneumoniae TIGR4 931443 NP_345849.1 CDS SP_1391 NC_003028.3 1315121 1315873 R hypothetical protein complement(1315121..1315873) Streptococcus pneumoniae TIGR4 931444 NP_345850.1 CDS SP_1392 NC_003028.3 1315883 1316614 R identified by match to TIGR protein family HMM TIGR01252; alpha-acetolactate decarboxylase complement(1315883..1316614) Streptococcus pneumoniae TIGR4 931445 NP_345851.1 CDS SP_1393 NC_003028.3 1316756 1318027 D hypothetical protein 1316756..1318027 Streptococcus pneumoniae TIGR4 931447 NP_345852.1 CDS SP_1394 NC_003028.3 1318047 1318862 R amino acid ABC transporter amino acid-binding protein complement(1318047..1318862) Streptococcus pneumoniae TIGR4 931446 NP_345853.1 CDS SP_1395 NC_003028.3 1319019 1319672 R similar to OMNI:NT01EC4457; identified by sequence similarity; phosphate transport system regulatory protein PhoU complement(1319019..1319672) Streptococcus pneumoniae TIGR4 931442 NP_345854.1 CDS SP_1396 NC_003028.3 1319684 1320442 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1319684..1320442) Streptococcus pneumoniae TIGR4 931441 NP_345855.1 CDS SP_1397 NC_003028.3 1320455 1321258 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1320455..1321258) Streptococcus pneumoniae TIGR4 931440 NP_345856.1 CDS SP_1398 NC_003028.3 1321269 1322153 R phosphate ABC transporter permease complement(1321269..1322153) Streptococcus pneumoniae TIGR4 931439 NP_345857.1 CDS SP_1399 NC_003028.3 1322143 1323060 R phosphate ABC transporter permease complement(1322143..1323060) Streptococcus pneumoniae TIGR4 931438 NP_345858.1 CDS SP_1400 NC_003028.3 1323060 1323938 R identified by match to PFAM protein family HMM PF01449; phosphate ABC transporter substrate-binding protein complement(1323060..1323938) Streptococcus pneumoniae TIGR4 931432 NP_345859.1 CDS SP_1401 NC_003028.3 1324090 1324281 D hypothetical protein 1324090..1324281 Streptococcus pneumoniae TIGR4 931433 NP_345860.1 CDS SP_1402 NC_003028.3 1324512 1325816 R identified by match to PFAM protein family HMM PF01189; NOL1/NOP2/sun family protein complement(1324512..1325816) Streptococcus pneumoniae TIGR4 931435 NP_345861.1 CDS SP_1403 NC_003028.3 1325817 1326590 R identified by match to PFAM protein family HMM PF00459; inositol monophosphatase complement(1325817..1326590) Streptococcus pneumoniae TIGR4 931430 NP_345862.1 CDS SP_1404 NC_003028.3 1326580 1326858 R hypothetical protein complement(1326580..1326858) Streptococcus pneumoniae TIGR4 931434 NP_345863.1 CDS spxA NC_003028.3 1326858 1327259 R the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx complement(1326858..1327259) Streptococcus pneumoniae TIGR4 931424 NP_345864.1 CDS SP_1406 NC_003028.3 1327469 1328086 R hypothetical protein complement(1327469..1328086) Streptococcus pneumoniae TIGR4 931427 NP_345865.1 CDS SP_1407 NC_003028.3 1328076 1328849 R identified by match to PFAM protein family HMM PF00702; HAD superfamily hydrolase complement(1328076..1328849) Streptococcus pneumoniae TIGR4 931429 NP_345866.1 CDS SP_1408 NC_003028.3 1328860 1329597 R identified by match to PFAM protein family HMM PF01643; acyl-ACP thioesterase complement(1328860..1329597) Streptococcus pneumoniae TIGR4 931428 NP_345867.1 CDS SP_1409 NC_003028.3 1329602 1330732 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(1329602..1330732) Streptococcus pneumoniae TIGR4 931425 NP_345868.1 CDS SP_1410 NC_003028.3 1330816 1331205 R hypothetical protein complement(1330816..1331205) Streptococcus pneumoniae TIGR4 931423 NP_345869.1 CDS SP_1411 NC_003028.3 1331221 1331604 R hypothetical protein complement(1331221..1331604) Streptococcus pneumoniae TIGR4 931431 NP_345870.1 CDS SP_1412 NC_003028.3 1331605 1332393 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(1331605..1332393) Streptococcus pneumoniae TIGR4 931418 NP_345871.1 CDS SP_1413 NC_003028.3 1332386 1333324 R catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase complement(1332386..1333324) Streptococcus pneumoniae TIGR4 931419 NP_345872.1 CDS rpsU NC_003028.3 1333451 1333627 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(1333451..1333627) Streptococcus pneumoniae TIGR4 931422 NP_345873.1 CDS SP_1415 NC_003028.3 1333773 1334474 R identified by match to PFAM protein family HMM PF01182; glucosamine-6-phosphate isomerase complement(1333773..1334474) Streptococcus pneumoniae TIGR4 931420 NP_345874.1 CDS queA NC_003028.3 1334625 1335653 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 1334625..1335653 Streptococcus pneumoniae TIGR4 931421 NP_345875.1 CDS SP_1418 NC_003028.3 1338003 1339349 D similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 1338003..1339349 Streptococcus pneumoniae TIGR4 931473 NP_345876.1 CDS SP_1419 NC_003028.3 1339908 1340459 R acetyltransferase complement(1339908..1340459) Streptococcus pneumoniae TIGR4 931474 NP_345877.1 CDS nadE NC_003028.3 1340809 1341633 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1340809..1341633) Streptococcus pneumoniae TIGR4 931416 NP_345878.1 CDS SP_1421 NC_003028.3 1341630 1343090 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1341630..1343090) Streptococcus pneumoniae TIGR4 931414 NP_345879.1 CDS SP_1422 NC_003028.3 1343206 1343694 R hypothetical protein complement(1343206..1343694) Streptococcus pneumoniae TIGR4 931405 NP_345880.1 CDS SP_1423 NC_003028.3 1343684 1343923 R transcriptional repressor complement(1343684..1343923) Streptococcus pneumoniae TIGR4 931409 NP_345881.1 CDS SP_1424 NC_003028.3 1344357 1344758 R hypothetical protein complement(1344357..1344758) Streptococcus pneumoniae TIGR4 931410 NP_345882.1 CDS SP_1425 NC_003028.3 1344774 1344908 R hypothetical protein complement(1344774..1344908) Streptococcus pneumoniae TIGR4 931413 NP_345883.1 CDS SP_1426 NC_003028.3 1344918 1345652 R ABC transporter ATP-binding protein complement(1344918..1345652) Streptococcus pneumoniae TIGR4 931388 NP_345884.1 CDS SP_1427 NC_003028.3 1345987 1346712 R identified by match to PFAM protein family HMM PF01136; U32 family peptidase complement(1345987..1346712) Streptococcus pneumoniae TIGR4 930073 NP_345885.1 CDS SP_1428 NC_003028.3 1346961 1347272 R hypothetical protein complement(1346961..1347272) Streptococcus pneumoniae TIGR4 931910 NP_345886.1 CDS SP_1429 NC_003028.3 1347287 1348573 R identified by match to PFAM protein family HMM PF01136; U32 family peptidase complement(1347287..1348573) Streptococcus pneumoniae TIGR4 931399 NP_345887.1 CDS SP_1431 NC_003028.3 1349751 1350941 D type II DNA modification methyltransferase 1349751..1350941 Streptococcus pneumoniae TIGR4 931411 NP_345888.1 CDS SP_1432 NC_003028.3 1351183 1351329 D hypothetical protein 1351183..1351329 Streptococcus pneumoniae TIGR4 931408 NP_345889.1 CDS SP_1433 NC_003028.3 1351451 1352443 R AraC family transcriptional regulator complement(1351451..1352443) Streptococcus pneumoniae TIGR4 931406 NP_345890.1 CDS SP_1434 NC_003028.3 1352597 1354357 D ABC transporter ATP-binding protein/permease 1352597..1354357 Streptococcus pneumoniae TIGR4 931407 NP_345891.1 CDS SP_1435 NC_003028.3 1354317 1356062 D ABC transporter ATP-binding protein 1354317..1356062 Streptococcus pneumoniae TIGR4 931404 NP_345892.1 CDS SP_1436 NC_003028.3 1356073 1356702 D hypothetical protein 1356073..1356702 Streptococcus pneumoniae TIGR4 931402 NP_345893.1 CDS SP_1437 NC_003028.3 1356717 1357160 D similar to GB:AE000512; identified by sequence similarity; hypothetical protein 1356717..1357160 Streptococcus pneumoniae TIGR4 931395 NP_345894.1 CDS SP_1438 NC_003028.3 1357148 1358272 D ABC transporter ATP-binding protein 1357148..1358272 Streptococcus pneumoniae TIGR4 931396 NP_345895.1 CDS SP_1439 NC_003028.3 1358413 1359759 D similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 1358413..1359759 Streptococcus pneumoniae TIGR4 931397 NP_345896.1 CDS SP_1442 NC_003028.3 1362492 1362842 R similar to GP:6009406; identified by sequence similarity; IS66 family Orf2 complement(1362492..1362842) Streptococcus pneumoniae TIGR4 931398 NP_345897.1 CDS SP_1443 NC_003028.3 1362823 1363062 R This region contains a gene with one or more premature stops or frameshifts, and is not the result of a sequencing artifact; Resembles an IS679 element (IS66 family); IS66 family Orf1 complement(1362823..1363062) Streptococcus pneumoniae TIGR4 931389 NP_345898.1 CDS SP_1444 NC_003028.3 1363255 1364511 D IS1167, transposase 1363255..1364511 Streptococcus pneumoniae TIGR4 931390 NP_345899.1 CDS guaA NC_003028.3 1364734 1366296 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(1364734..1366296) Streptococcus pneumoniae TIGR4 931393 NP_345900.1 CDS SP_1446 NC_003028.3 1366429 1367136 D GntR family transcriptional regulator 1366429..1367136 Streptococcus pneumoniae TIGR4 931394 NP_345901.1 CDS SP_1447 NC_003028.3 1367179 1368075 R hypothetical protein complement(1367179..1368075) Streptococcus pneumoniae TIGR4 931392 NP_345902.1 CDS SP_1448 NC_003028.3 1368084 1369019 R hypothetical protein complement(1368084..1369019) Streptococcus pneumoniae TIGR4 931391 NP_345903.1 CDS SP_1449 NC_003028.3 1369016 1369741 R similar to GP:5001711; identified by sequence similarity; C3-degrading proteinase complement(1369016..1369741) Streptococcus pneumoniae TIGR4 931387 NP_345904.1 CDS SP_1450 NC_003028.3 1369825 1370460 R platelet activating factor complement(1369825..1370460) Streptococcus pneumoniae TIGR4 931386 NP_345905.1 CDS SP_1451 NC_003028.3 1370462 1371289 R Cof family protein complement(1370462..1371289) Streptococcus pneumoniae TIGR4 931385 NP_345906.1 CDS SP_1452 NC_003028.3 1371311 1371610 R hypothetical protein complement(1371311..1371610) Streptococcus pneumoniae TIGR4 931378 NP_345907.1 CDS SP_1453 NC_003028.3 1371647 1372159 R similar to GB:M24150 SP:P19579 PID:142633; identified by sequence similarity; hypothetical protein complement(1371647..1372159) Streptococcus pneumoniae TIGR4 931380 NP_345908.1 CDS SP_1454 NC_003028.3 1372253 1372375 R hypothetical protein complement(1372253..1372375) Streptococcus pneumoniae TIGR4 931381 NP_345909.1 CDS SP_1455 NC_003028.3 1372518 1372709 R hypothetical protein complement(1372518..1372709) Streptococcus pneumoniae TIGR4 931382 NP_345910.1 CDS def NC_003028.3 1372898 1373509 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1372898..1373509 Streptococcus pneumoniae TIGR4 931384 NP_345911.1 CDS SP_1457 NC_003028.3 1373554 1374282 D spoU rRNA methylase 1373554..1374282 Streptococcus pneumoniae TIGR4 931383 NP_345912.1 CDS SP_1458 NC_003028.3 1374321 1375232 R identified by match to TIGR protein family HMM TIGR01292; thioredoxin reductase complement(1374321..1375232) Streptococcus pneumoniae TIGR4 931372 NP_345913.1 CDS SP_1459 NC_003028.3 1375298 1375534 R hypothetical protein complement(1375298..1375534) Streptococcus pneumoniae TIGR4 931373 NP_345914.1 CDS SP_1460 NC_003028.3 1375600 1376343 R amino acid ABC transporter ATP-binding protein complement(1375600..1376343) Streptococcus pneumoniae TIGR4 931376 NP_345915.1 CDS SP_1461 NC_003028.3 1376343 1377143 R amino acid ABC transporter permease complement(1376343..1377143) Streptococcus pneumoniae TIGR4 931377 NP_345916.1 CDS SP_1462 NC_003028.3 1377301 1377657 R hypothetical protein complement(1377301..1377657) Streptococcus pneumoniae TIGR4 929756 NP_345917.1 CDS SP_1463 NC_003028.3 1377651 1378181 R identified by match to PFAM protein family HMM PF01035; methylated-DNA--protein-cysteine S-methyltransferase complement(1377651..1378181) Streptococcus pneumoniae TIGR4 931367 NP_345918.1 CDS SP_1464 NC_003028.3 1378181 1378675 R acetyltransferase complement(1378181..1378675) Streptococcus pneumoniae TIGR4 931379 NP_345919.1 CDS SP_1465 NC_003028.3 1378810 1379256 D hypothetical protein 1378810..1379256 Streptococcus pneumoniae TIGR4 931375 NP_345920.1 CDS SP_1466 NC_003028.3 1379253 1379900 D similar to PID:662880 SP:P54176; identified by sequence similarity; hemolysin 1379253..1379900 Streptococcus pneumoniae TIGR4 931374 NP_345921.1 CDS SP_1467 NC_003028.3 1379921 1380502 R with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT complement(1379921..1380502) Streptococcus pneumoniae TIGR4 931371 NP_345922.1 CDS SP_1468 NC_003028.3 1380503 1381378 R with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS complement(1380503..1381378) Streptococcus pneumoniae TIGR4 931370 NP_345923.1 CDS SP_1469 NC_003028.3 1381530 1382909 R NADH oxidase complement(1381530..1382909) Streptococcus pneumoniae TIGR4 931369 NP_345924.1 CDS SP_1470 NC_003028.3 1383203 1384126 D similar to PID:1906609; identified by sequence similarity; thiamine biosynthesis protein ApbE 1383203..1384126 Streptococcus pneumoniae TIGR4 931368 NP_345925.1 CDS SP_1471 NC_003028.3 1384186 1384791 D similar to GB:L10328 SP:P31465 PID:290561 GB:U00096 PID:1790149; identified by sequence similarity; oxidoreductase 1384186..1384791 Streptococcus pneumoniae TIGR4 931361 NP_345926.1 CDS SP_1472 NC_003028.3 1384810 1386054 D similar to GB:L10328 SP:P31465 PID:290561 GB:U00096 PID:1790149; identified by sequence similarity; oxidoreductase 1384810..1386054 Streptococcus pneumoniae TIGR4 931365 NP_345927.1 CDS SP_1473 NC_003028.3 1386277 1386534 R hypothetical protein complement(1386277..1386534) Streptococcus pneumoniae TIGR4 931366 NP_345928.1 CDS glyS NC_003028.3 1386576 1388612 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(1386576..1388612) Streptococcus pneumoniae TIGR4 931364 NP_345929.1 CDS glyQ NC_003028.3 1388824 1389741 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(1388824..1389741) Streptococcus pneumoniae TIGR4 931363 NP_345930.1 CDS SP_1476 NC_003028.3 1390112 1390501 R hypothetical protein complement(1390112..1390501) Streptococcus pneumoniae TIGR4 931362 NP_345931.1 CDS SP_1477 NC_003028.3 1390483 1390890 R hypothetical protein complement(1390483..1390890) Streptococcus pneumoniae TIGR4 931353 NP_345932.1 CDS SP_1478 NC_003028.3 1391145 1391987 R aldo/keto reductase complement(1391145..1391987) Streptococcus pneumoniae TIGR4 931354 NP_345933.1 CDS SP_1479 NC_003028.3 1392101 1393492 R identified by match to PFAM protein family HMM PF01522; peptidoglycan N-acetylglucosamine deacetylase A complement(1392101..1393492) Streptococcus pneumoniae TIGR4 931360 NP_345934.1 CDS SP_1480 NC_003028.3 1393727 1393972 R hypothetical protein complement(1393727..1393972) Streptococcus pneumoniae TIGR4 931347 NP_345935.1 CDS SP_1481 NC_003028.3 1393997 1394104 R hypothetical protein complement(1393997..1394104) Streptococcus pneumoniae TIGR4 931351 NP_345936.1 CDS SP_1482 NC_003028.3 1394319 1395296 D Gfo/Idh/MocA family oxidoreductase 1394319..1395296 Streptococcus pneumoniae TIGR4 931358 NP_345937.1 CDS SP_1483 NC_003028.3 1395293 1396375 D DEAD/DEAH box helicase 1395293..1396375 Streptococcus pneumoniae TIGR4 931359 NP_345938.1 CDS SP_1485 NC_003028.3 1397026 1397859 R IS3-Spn1, transposase complement(1397026..1397859) Streptococcus pneumoniae TIGR4 931356 NP_345939.1 CDS SP_1487 NC_003028.3 1398351 1398689 R hypothetical protein complement(1398351..1398689) Streptococcus pneumoniae TIGR4 931352 NP_345940.1 CDS SP_1488 NC_003028.3 1398812 1398952 R hypothetical protein complement(1398812..1398952) Streptococcus pneumoniae TIGR4 931350 NP_345941.1 CDS tuf NC_003028.3 1399336 1400532 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(1399336..1400532) Streptococcus pneumoniae TIGR4 931349 NP_345942.1 CDS SP_1490 NC_003028.3 1400739 1400834 R hypothetical protein complement(1400739..1400834) Streptococcus pneumoniae TIGR4 931336 NP_345943.1 CDS SP_1491 NC_003028.3 1401454 1402323 R identified by match to PFAM protein family HMM PF00230; glycerol uptake facilitator protein complement(1401454..1402323) Streptococcus pneumoniae TIGR4 931341 NP_345944.1 CDS SP_1492 NC_003028.3 1402547 1403155 R identified by match to PFAM protein family HMM PF00746; cell wall surface anchor family protein complement(1402547..1403155) Streptococcus pneumoniae TIGR4 931342 NP_345945.1 CDS SP_1493 NC_003028.3 1403113 1404225 R hypothetical protein complement(1403113..1404225) Streptococcus pneumoniae TIGR4 931345 NP_345946.1 CDS SP_1494 NC_003028.3 1404330 1404584 R hypothetical protein complement(1404330..1404584) Streptococcus pneumoniae TIGR4 931348 NP_345947.1 CDS SP_1495 NC_003028.3 1404578 1404820 R hypothetical protein complement(1404578..1404820) Streptococcus pneumoniae TIGR4 931478 NP_345948.1 CDS SP_1496 NC_003028.3 1404942 1405241 R similar to GP:5019553; identified by sequence similarity; transposase, IS630-Spn1 related, Orf2 complement(1404942..1405241) Streptococcus pneumoniae TIGR4 931344 NP_345949.1 CDS SP_1498 NC_003028.3 1406020 1407738 D phosphoglucomutase 1406020..1407738 Streptococcus pneumoniae TIGR4 931340 NP_345950.1 CDS SP_1499 NC_003028.3 1407849 1408196 D similar to GP:5929888; identified by sequence similarity; bacterocin transport accessory protein 1407849..1408196 Streptococcus pneumoniae TIGR4 931339 NP_345951.1 CDS SP_1500 NC_003028.3 1408475 1409311 R amino acid ABC transporter amino acid-binding protein complement(1408475..1409311) Streptococcus pneumoniae TIGR4 931338 NP_345952.1 CDS SP_1501 NC_003028.3 1409324 1409953 R amino acid ABC transporter ATP-binding protein complement(1409324..1409953) Streptococcus pneumoniae TIGR4 931337 NP_345953.1 CDS SP_1502 NC_003028.3 1409963 1410604 R amino acid ABC transporter permease complement(1409963..1410604) Streptococcus pneumoniae TIGR4 931331 NP_345954.1 CDS SP_1503 NC_003028.3 1410910 1412256 D similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 1410910..1412256 Streptococcus pneumoniae TIGR4 931332 NP_345955.1 CDS SP_1504 NC_003028.3 1412458 1413669 R hypothetical protein complement(1412458..1413669) Streptococcus pneumoniae TIGR4 931334 NP_345956.1 CDS SP_1505 NC_003028.3 1413677 1414843 R hypothetical protein complement(1413677..1414843) Streptococcus pneumoniae TIGR4 931335 NP_345957.1 CDS SP_1506 NC_003028.3 1414987 1416000 D hypothetical protein 1414987..1416000 Streptococcus pneumoniae TIGR4 931333 NP_345958.1 CDS atpC NC_003028.3 1416045 1416464 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon complement(1416045..1416464) Streptococcus pneumoniae TIGR4 931476 NP_345959.1 CDS SP_1508 NC_003028.3 1416475 1417881 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta complement(1416475..1417881) Streptococcus pneumoniae TIGR4 931477 NP_345960.1 CDS SP_1509 NC_003028.3 1417967 1418845 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma complement(1417967..1418845) Streptococcus pneumoniae TIGR4 931325 NP_345961.1 CDS SP_1510 NC_003028.3 1418861 1420366 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha complement(1418861..1420366) Streptococcus pneumoniae TIGR4 931329 NP_345962.1 CDS SP_1511 NC_003028.3 1420381 1420917 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta complement(1420381..1420917) Streptococcus pneumoniae TIGR4 931327 NP_345963.1 CDS SP_1512 NC_003028.3 1420917 1421411 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B complement(1420917..1421411) Streptococcus pneumoniae TIGR4 931330 NP_345964.1 CDS SP_1513 NC_003028.3 1421425 1422141 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A complement(1421425..1422141) Streptococcus pneumoniae TIGR4 931328 NP_345965.1 CDS SP_1514 NC_003028.3 1422176 1422376 R produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C complement(1422176..1422376) Streptococcus pneumoniae TIGR4 931326 NP_345966.1 CDS SP_1516 NC_003028.3 1423902 1424330 R acetyltransferase complement(1423902..1424330) Streptococcus pneumoniae TIGR4 931322 NP_345967.1 CDS greA NC_003028.3 1424808 1425290 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1424808..1425290) Streptococcus pneumoniae TIGR4 931316 NP_345968.1 CDS SP_1518 NC_003028.3 1425361 1427016 R hypothetical protein complement(1425361..1427016) Streptococcus pneumoniae TIGR4 931319 NP_345969.1 CDS SP_1519 NC_003028.3 1427097 1427591 R acetyltransferase complement(1427097..1427591) Streptococcus pneumoniae TIGR4 931320 NP_345970.1 CDS SP_1520 NC_003028.3 1427588 1428052 R acetyltransferase complement(1427588..1428052) Streptococcus pneumoniae TIGR4 931318 NP_345971.1 CDS murC NC_003028.3 1428062 1429396 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(1428062..1429396) Streptococcus pneumoniae TIGR4 931317 NP_345972.1 CDS SP_1522 NC_003028.3 1429407 1430024 R similar to SP:Q09202 PID:643097; identified by sequence similarity; hypothetical protein complement(1429407..1430024) Streptococcus pneumoniae TIGR4 931315 NP_345973.1 CDS SP_1523 NC_003028.3 1430072 1433170 R Snf2 family protein complement(1430072..1433170) Streptococcus pneumoniae TIGR4 931313 NP_345974.1 CDS SP_1524 NC_003028.3 1433263 1434429 R class II aminotransferase complement(1433263..1434429) Streptococcus pneumoniae TIGR4 931312 NP_345975.1 CDS SP_1525 NC_003028.3 1434437 1435531 R catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase complement(1434437..1435531) Streptococcus pneumoniae TIGR4 931311 NP_345976.1 CDS SP_1527 NC_003028.3 1437536 1439494 R oligopeptide ABC transporter oligopeptide-binding protein AliB complement(1437536..1439494) Streptococcus pneumoniae TIGR4 931305 NP_345977.1 CDS SP_1528 NC_003028.3 1439481 1439576 R hypothetical protein complement(1439481..1439576) Streptococcus pneumoniae TIGR4 931306 NP_345978.1 CDS SP_1529 NC_003028.3 1439697 1441286 R polysaccharide biosynthesis protein complement(1439697..1441286) Streptococcus pneumoniae TIGR4 931308 NP_345979.1 CDS murE NC_003028.3 1441425 1442870 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1441425..1442870 Streptococcus pneumoniae TIGR4 931309 NP_345980.1 CDS SP_1531 NC_003028.3 1442913 1443110 R hypothetical protein complement(1442913..1443110) Streptococcus pneumoniae TIGR4 931307 NP_345981.1 CDS SP_1533 NC_003028.3 1443844 1444356 R similar to PID:1216309; identified by sequence similarity; hypothetical protein complement(1443844..1444356) Streptococcus pneumoniae TIGR4 931303 NP_345982.1 CDS SP_1534 NC_003028.3 1444442 1445377 R catalyzes the hydrolysis of pyrophosphate to phosphate; manganese-dependent inorganic pyrophosphatase complement(1444442..1445377) Streptococcus pneumoniae TIGR4 931304 NP_345983.1 CDS SP_1535 NC_003028.3 1445448 1445747 R hypothetical protein complement(1445448..1445747) Streptococcus pneumoniae TIGR4 931300 NP_345984.1 CDS SP_1536 NC_003028.3 1445737 1446486 R hypothetical protein complement(1445737..1446486) Streptococcus pneumoniae TIGR4 931301 NP_345985.1 CDS SP_1537 NC_003028.3 1446540 1446899 R hypothetical protein complement(1446540..1446899) Streptococcus pneumoniae TIGR4 931298 NP_345986.1 CDS SP_1538 NC_003028.3 1446901 1448301 R Cof family protein/peptidyl-prolyl cis-trans isomerase, cyclophilin type complement(1446901..1448301) Streptococcus pneumoniae TIGR4 931302 NP_345987.1 CDS rpsR NC_003028.3 1448596 1448835 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(1448596..1448835) Streptococcus pneumoniae TIGR4 931284 NP_345988.1 CDS SP_1540 NC_003028.3 1448867 1449337 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1448867..1449337) Streptococcus pneumoniae TIGR4 931283 NP_345989.1 CDS rpsF NC_003028.3 1449349 1449639 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(1449349..1449639) Streptococcus pneumoniae TIGR4 931287 NP_345990.1 CDS asnC NC_003028.3 1449792 1451135 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(1449792..1451135) Streptococcus pneumoniae TIGR4 931292 NP_345991.1 CDS SP_1544 NC_003028.3 1451512 1452699 R catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase complement(1451512..1452699) Streptococcus pneumoniae TIGR4 931296 NP_345992.1 CDS SP_1545 NC_003028.3 1452696 1453127 R hypothetical protein complement(1452696..1453127) Streptococcus pneumoniae TIGR4 931295 NP_345993.1 CDS SP_1546 NC_003028.3 1453424 1454053 D similar to GP:6562870; identified by sequence similarity; hypothetical protein 1453424..1454053 Streptococcus pneumoniae TIGR4 931294 NP_345994.1 CDS SP_1547 NC_003028.3 1454330 1455058 R hypothetical protein complement(1454330..1455058) Streptococcus pneumoniae TIGR4 931293 NP_345995.1 CDS SP_1548 NC_003028.3 1455368 1456963 R hypothetical protein complement(1455368..1456963) Streptococcus pneumoniae TIGR4 931291 NP_345996.1 CDS SP_1549 NC_003028.3 1456975 1457385 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(1456975..1457385) Streptococcus pneumoniae TIGR4 931290 NP_345997.1 CDS SP_1550 NC_003028.3 1457501 1458292 R YghU; B2989; one of eight glutathione transferase proteins from E. coli; glutathione S-transferase complement(1457501..1458292) Streptococcus pneumoniae TIGR4 931289 NP_345998.1 CDS SP_1551 NC_003028.3 1458305 1461049 R identified by match to PFAM protein family HMM PF00690; cation transporter E1-E2 family ATPase complement(1458305..1461049) Streptococcus pneumoniae TIGR4 931288 NP_345999.1 CDS SP_1552 NC_003028.3 1461305 1462489 D identified by match to PFAM protein family HMM PF01545; cation efflux family protein 1461305..1462489 Streptococcus pneumoniae TIGR4 931190 NP_346000.1 CDS SP_1553 NC_003028.3 1462632 1464503 R ABC transporter ATP-binding protein complement(1462632..1464503) Streptococcus pneumoniae TIGR4 931231 NP_346001.1 CDS SP_1554 NC_003028.3 1464500 1465684 R catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase complement(1464500..1465684) Streptococcus pneumoniae TIGR4 931251 NP_346002.1 CDS SP_1555 NC_003028.3 1465696 1466463 R catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase complement(1465696..1466463) Streptococcus pneumoniae TIGR4 931285 NP_346003.1 CDS SP_1556 NC_003028.3 1466560 1466697 R hypothetical protein complement(1466560..1466697) Streptococcus pneumoniae TIGR4 931282 NP_346004.1 CDS SP_1557 NC_003028.3 1466740 1467588 R degV family protein complement(1466740..1467588) Streptococcus pneumoniae TIGR4 931281 NP_346005.1 CDS SP_1558 NC_003028.3 1467590 1467976 R hypothetical protein complement(1467590..1467976) Streptococcus pneumoniae TIGR4 931280 NP_346006.1 CDS glmM NC_003028.3 1468038 1469390 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(1468038..1469390) Streptococcus pneumoniae TIGR4 931273 NP_346007.1 CDS SP_1560 NC_003028.3 1469414 1470193 R hypothetical protein complement(1469414..1470193) Streptococcus pneumoniae TIGR4 931274 NP_346008.1 CDS SP_1561 NC_003028.3 1470180 1470950 R hypothetical protein complement(1470180..1470950) Streptococcus pneumoniae TIGR4 931277 NP_346009.1 CDS SP_1562 NC_003028.3 1470955 1471128 R hypothetical protein complement(1470955..1471128) Streptococcus pneumoniae TIGR4 931279 NP_346010.1 CDS SP_1563 NC_003028.3 1471173 1472138 D pyridine nucleotide-disulfide oxidoreductase family protein 1471173..1472138 Streptococcus pneumoniae TIGR4 931278 NP_346011.1 CDS SP_1564 NC_003028.3 1472172 1473083 R hypothetical protein complement(1472172..1473083) Streptococcus pneumoniae TIGR4 931276 NP_346012.1 CDS SP_1565 NC_003028.3 1473080 1474057 R hypothetical protein complement(1473080..1474057) Streptococcus pneumoniae TIGR4 931275 NP_346013.1 CDS SP_1566 NC_003028.3 1474054 1474944 R hypothetical protein complement(1474054..1474944) Streptococcus pneumoniae TIGR4 931272 NP_346014.1 CDS SP_1567 NC_003028.3 1474996 1475376 R endoribonuclease L-PSP complement(1474996..1475376) Streptococcus pneumoniae TIGR4 931271 NP_346015.1 CDS engB NC_003028.3 1475387 1475974 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(1475387..1475974) Streptococcus pneumoniae TIGR4 931264 NP_346016.1 CDS clpX NC_003028.3 1475983 1477215 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1475983..1477215) Streptococcus pneumoniae TIGR4 931266 NP_346017.1 CDS SP_1570 NC_003028.3 1477247 1477417 R hypothetical protein complement(1477247..1477417) Streptococcus pneumoniae TIGR4 931269 NP_346018.1 CDS SP_1571 NC_003028.3 1477417 1477923 R dihydrofolate reductase complement(1477417..1477923) Streptococcus pneumoniae TIGR4 931270 NP_346019.1 CDS SP_1572 NC_003028.3 1478053 1478589 R identified by match to PFAM protein family HMM PF02047; non-heme iron-containing ferritin complement(1478053..1478589) Streptococcus pneumoniae TIGR4 931267 YP_873931.1 CDS lytC NC_003028.3 1479067 1480539 R lysozyme complement(1479067..1480539) Streptococcus pneumoniae TIGR4 931265 NP_346020.1 CDS tpiA NC_003028.3 1480609 1481367 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(1480609..1481367) Streptococcus pneumoniae TIGR4 931262 NP_346021.1 CDS SP_1575 NC_003028.3 1481465 1482142 R hypothetical protein complement(1481465..1482142) Streptococcus pneumoniae TIGR4 931256 NP_346022.1 CDS SP_1576 NC_003028.3 1482151 1483095 R catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase complement(1482151..1483095) Streptococcus pneumoniae TIGR4 931257 NP_346023.1 CDS SP_1577 NC_003028.3 1483277 1483789 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(1483277..1483789) Streptococcus pneumoniae TIGR4 931260 NP_346024.1 CDS SP_1578 NC_003028.3 1483876 1484634 R hypothetical protein complement(1483876..1484634) Streptococcus pneumoniae TIGR4 931261 NP_346025.1 CDS SP_1579 NC_003028.3 1484607 1484729 R hypothetical protein complement(1484607..1484729) Streptococcus pneumoniae TIGR4 931259 NP_346026.1 CDS SP_1580 NC_003028.3 1485135 1486265 R sugar ABC transporter ATP-binding protein complement(1485135..1486265) Streptococcus pneumoniae TIGR4 931258 NP_346027.1 CDS SP_1581 NC_003028.3 1486366 1486494 D hypothetical protein 1486366..1486494 Streptococcus pneumoniae TIGR4 931255 NP_346028.1 CDS SP_1582 NC_003028.3 1486593 1487849 D IS1167, transposase 1486593..1487849 Streptococcus pneumoniae TIGR4 931246 NP_346029.1 CDS SP_1583 NC_003028.3 1488139 1488714 R identified by match to PFAM protein family HMM PF00857; isochorismatase complement(1488139..1488714) Streptococcus pneumoniae TIGR4 931253 NP_346030.1 CDS SP_1584 NC_003028.3 1488714 1489502 R CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY complement(1488714..1489502) Streptococcus pneumoniae TIGR4 931252 NP_346031.1 CDS SP_1585 NC_003028.3 1489654 1489791 D hypothetical protein 1489654..1489791 Streptococcus pneumoniae TIGR4 931250 NP_346032.1 CDS SP_1586 NC_003028.3 1489766 1491340 R ATP-dependent RNA helicase complement(1489766..1491340) Streptococcus pneumoniae TIGR4 931248 NP_346033.1 CDS SP_1587 NC_003028.3 1491539 1492765 R oxalate:formate antiporter complement(1491539..1492765) Streptococcus pneumoniae TIGR4 931247 NP_346034.1 CDS SP_1588 NC_003028.3 1492958 1494274 D Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 1492958..1494274 Streptococcus pneumoniae TIGR4 931244 NP_346035.1 CDS SP_1589 NC_003028.3 1494373 1495716 D hypothetical protein 1494373..1495716 Streptococcus pneumoniae TIGR4 931245 NP_346036.1 CDS SP_1590 NC_003028.3 1495716 1496498 D hypothetical protein 1495716..1496498 Streptococcus pneumoniae TIGR4 931263 NP_346037.1 CDS SP_1591 NC_003028.3 1496624 1497706 D identified by match to PFAM protein family HMM PF00557; proline dipeptidase 1496624..1497706 Streptococcus pneumoniae TIGR4 931254 NP_346038.1 CDS SP_1592 NC_003028.3 1497699 1497902 D similar to PID:1196899; identified by sequence similarity; hypothetical protein 1497699..1497902 Streptococcus pneumoniae TIGR4 931268 NP_346039.1 CDS SP_1595 NC_003028.3 1499265 1500611 D similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase 1499265..1500611 Streptococcus pneumoniae TIGR4 931242 NP_346040.1 CDS SP_1596 NC_003028.3 1500752 1501006 R hypothetical protein complement(1500752..1501006) Streptococcus pneumoniae TIGR4 931243 NP_346041.1 CDS SP_1597 NC_003028.3 1501234 1501695 R hypothetical protein complement(1501234..1501695) Streptococcus pneumoniae TIGR4 931237 NP_346042.1 CDS SP_1598 NC_003028.3 1501673 1502446 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(1501673..1502446) Streptococcus pneumoniae TIGR4 931240 NP_346043.1 CDS truA NC_003028.3 1502436 1503185 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(1502436..1503185) Streptococcus pneumoniae TIGR4 931236 NP_346044.1 CDS SP_1600 NC_003028.3 1503503 1504654 R hypothetical protein complement(1503503..1504654) Streptococcus pneumoniae TIGR4 931226 NP_346045.1 CDS SP_1601 NC_003028.3 1504894 1505523 R hypothetical protein complement(1504894..1505523) Streptococcus pneumoniae TIGR4 931228 NP_346046.1 CDS SP_1602 NC_003028.3 1505526 1505864 R phnA protein complement(1505526..1505864) Streptococcus pneumoniae TIGR4 931234 NP_346047.1 CDS cmk NC_003028.3 1505995 1506666 R Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase complement(1505995..1506666) Streptococcus pneumoniae TIGR4 931235 NP_346048.1 CDS SP_1604 NC_003028.3 1506675 1507151 R hypothetical protein complement(1506675..1507151) Streptococcus pneumoniae TIGR4 931233 NP_346049.1 CDS SP_1605 NC_003028.3 1507203 1507409 D ferredoxin 1507203..1507409 Streptococcus pneumoniae TIGR4 931232 NP_346050.1 CDS SP_1606 NC_003028.3 1507460 1508422 R glycosyl transferase family protein complement(1507460..1508422) Streptococcus pneumoniae TIGR4 931483 NP_346051.1 CDS SP_1607 NC_003028.3 1508427 1509446 R identified by match to TIGR protein family HMM TIGR01179; UDP-glucose 4-epimerase complement(1508427..1509446) Streptococcus pneumoniae TIGR4 931229 NP_346052.1 CDS SP_1608 NC_003028.3 1509747 1510850 R identified by match to PFAM protein family HMM PF01266; oxidoreductase, DadA family protein complement(1509747..1510850) Streptococcus pneumoniae TIGR4 931227 NP_346053.1 CDS SP_1609 NC_003028.3 1510867 1511664 R hypothetical protein complement(1510867..1511664) Streptococcus pneumoniae TIGR4 931218 NP_346054.1 CDS SP_1610 NC_003028.3 1511651 1512328 R identified by match to PFAM protein family HMM PF00452; hypothetical protein complement(1511651..1512328) Streptococcus pneumoniae TIGR4 931215 NP_346055.1 CDS SP_1611 NC_003028.3 1512686 1512790 D hypothetical protein 1512686..1512790 Streptococcus pneumoniae TIGR4 931211 NP_346056.1 CDS SP_1612 NC_003028.3 1512877 1513869 D similar to GP:3582249; identified by sequence similarity; hypothetical protein 1512877..1513869 Streptococcus pneumoniae TIGR4 931225 YP_873932.1 CDS recP-1 NC_003028.3 1515589 1517556 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(1515589..1517556) Streptococcus pneumoniae TIGR4 4484196 NP_346057.1 CDS SP_1616 NC_003028.3 1517593 1518288 R identified by match to PFAM protein family HMM PF00834; allulose-6-phosphate 3-epimerase complement(1517593..1518288) Streptococcus pneumoniae TIGR4 931221 NP_346058.1 CDS SP_1617 NC_003028.3 1518299 1519384 R PTS system transporter subunit IIC complement(1518299..1519384) Streptococcus pneumoniae TIGR4 931224 NP_346059.1 CDS SP_1618 NC_003028.3 1519410 1519736 R PTS system transporter subunit IIB complement(1519410..1519736) Streptococcus pneumoniae TIGR4 931223 NP_346060.1 CDS SP_1619 NC_003028.3 1519749 1520198 R PTS system transporter subunit IIA complement(1519749..1520198) Streptococcus pneumoniae TIGR4 931222 NP_346061.1 CDS SP_1620 NC_003028.3 1520176 1520604 R PTS system nitrogen regulatory IIA complement(1520176..1520604) Streptococcus pneumoniae TIGR4 931220 YP_873933.1 CDS SP_1621 NC_003028.3 1520597 1522060 R transcription antiterminator BglG family protein complement(1520597..1522060) Streptococcus pneumoniae TIGR4 931217 NP_346062.1 CDS SP_1622 NC_003028.3 1522724 1523197 D IS200 family transposase 1522724..1523197 Streptococcus pneumoniae TIGR4 931216 NP_346063.1 CDS SP_1623 NC_003028.3 1523328 1525664 R cation transporter E1-E2 family ATPase complement(1523328..1525664) Streptococcus pneumoniae TIGR4 931480 NP_346064.1 CDS SP_1624 NC_003028.3 1525797 1526546 D identified by match to PFAM protein family HMM PF01553; acyltransferase 1525797..1526546 Streptococcus pneumoniae TIGR4 931482 NP_346065.1 CDS SP_1625 NC_003028.3 1526838 1527452 R cadmium resistance transporter complement(1526838..1527452) Streptococcus pneumoniae TIGR4 931479 NP_346066.1 CDS rpsO NC_003028.3 1528268 1528537 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(1528268..1528537) Streptococcus pneumoniae TIGR4 931214 NP_346067.1 CDS SP_1627 NC_003028.3 1528678 1529307 R hypothetical protein complement(1528678..1529307) Streptococcus pneumoniae TIGR4 931213 NP_346068.1 CDS SP_1628 NC_003028.3 1529535 1529744 D hypothetical protein 1529535..1529744 Streptococcus pneumoniae TIGR4 931212 NP_346069.1 CDS SP_1629 NC_003028.3 1529814 1529918 D hypothetical protein 1529814..1529918 Streptococcus pneumoniae TIGR4 931209 NP_346070.1 CDS SP_1630 NC_003028.3 1530109 1530498 D hypothetical protein 1530109..1530498 Streptococcus pneumoniae TIGR4 931199 NP_346071.1 CDS thrS NC_003028.3 1530556 1532499 D catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1530556..1532499 Streptococcus pneumoniae TIGR4 931203 NP_346072.1 CDS SP_1632 NC_003028.3 1532548 1533522 R sensor histidine kinase complement(1532548..1533522) Streptococcus pneumoniae TIGR4 931201 NP_346073.1 CDS SP_1633 NC_003028.3 1533515 1534192 R DNA-binding response regulator complement(1533515..1534192) Streptococcus pneumoniae TIGR4 931206 NP_346074.1 CDS SP_1634 NC_003028.3 1534348 1535421 D hypothetical protein 1534348..1535421 Streptococcus pneumoniae TIGR4 931208 NP_346075.1 CDS SP_1635 NC_003028.3 1535512 1535814 R hypothetical protein complement(1535512..1535814) Streptococcus pneumoniae TIGR4 931207 NP_346076.1 CDS SP_1636 NC_003028.3 1535882 1536319 R Rrf2 family protein complement(1535882..1536319) Streptococcus pneumoniae TIGR4 931205 NP_346077.1 CDS SP_1637 NC_003028.3 1536395 1537243 R hypothetical protein complement(1536395..1537243) Streptococcus pneumoniae TIGR4 931202 NP_346078.1 CDS SP_1638 NC_003028.3 1537349 1537999 D identified by match to PFAM protein family HMM PF01325; iron-dependent transcriptional regulator 1537349..1537999 Streptococcus pneumoniae TIGR4 931200 NP_346079.1 CDS SP_1639 NC_003028.3 1538071 1539345 R IS1167, transposase complement(1538071..1539345) Streptococcus pneumoniae TIGR4 931198 NP_346080.1 CDS SP_1640 NC_003028.3 1539742 1540263 D hypothetical protein 1539742..1540263 Streptococcus pneumoniae TIGR4 931197 NP_346081.1 CDS SP_1641 NC_003028.3 1540394 1540807 D similar to GB:AL009126; identified by sequence similarity; hypothetical protein 1540394..1540807 Streptococcus pneumoniae TIGR4 931196 NP_346082.1 CDS SP_1642 NC_003028.3 1540826 1541011 D hypothetical protein 1540826..1541011 Streptococcus pneumoniae TIGR4 931195 NP_346083.1 CDS SP_1643 NC_003028.3 1541078 1541239 D hypothetical protein 1541078..1541239 Streptococcus pneumoniae TIGR4 931194 NP_346084.1 CDS SP_1644 NC_003028.3 1541278 1541721 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(1541278..1541721) Streptococcus pneumoniae TIGR4 931193 NP_346085.1 CDS SP_1645 NC_003028.3 1541751 1543973 R GTP pyrophosphokinase complement(1541751..1543973) Streptococcus pneumoniae TIGR4 931192 NP_346086.1 CDS SP_1646 NC_003028.3 1544932 1545561 D metallo-beta-lactamase superfamily protein 1544932..1545561 Streptococcus pneumoniae TIGR4 931191 NP_346087.1 CDS SP_1647 NC_003028.3 1545684 1547576 R identified by match to PFAM protein family HMM PF01431; endopeptidase O complement(1545684..1547576) Streptococcus pneumoniae TIGR4 931189 NP_346088.1 CDS SP_1648 NC_003028.3 1547867 1548589 D manganese ABC transporter ATP-binding protein 1547867..1548589 Streptococcus pneumoniae TIGR4 931188 YP_873934.1 CDS SP_1649 NC_003028.3 1548586 1549434 D manganese ABC transporter permease 1548586..1549434 Streptococcus pneumoniae TIGR4 931187 NP_346089.1 CDS SP_1650 NC_003028.3 1549466 1550395 D identified by match to PFAM protein family HMM PF01297; manganese ABC transporter manganese-binding adhesion liprotein 1549466..1550395 Streptococcus pneumoniae TIGR4 931186 NP_346090.3 CDS tpx NC_003028.3 1550491 1551009 D antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1550491..1551009 Streptococcus pneumoniae TIGR4 931172 NP_346091.1 CDS SP_1652 NC_003028.3 1551105 1553879 R hypothetical protein complement(1551105..1553879) Streptococcus pneumoniae TIGR4 931175 NP_346092.1 CDS SP_1653 NC_003028.3 1553815 1554516 R ABC transporter ATP-binding protein complement(1553815..1554516) Streptococcus pneumoniae TIGR4 931184 NP_346093.1 CDS SP_1654 NC_003028.3 1554766 1557177 R hypothetical protein complement(1554766..1557177) Streptococcus pneumoniae TIGR4 931185 NP_346094.1 CDS gpmA NC_003028.3 1557230 1557922 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(1557230..1557922) Streptococcus pneumoniae TIGR4 931183 NP_346095.1 CDS SP_1656 NC_003028.3 1557973 1558161 R hypothetical protein complement(1557973..1558161) Streptococcus pneumoniae TIGR4 931182 NP_346096.1 CDS SP_1657 NC_003028.3 1558244 1558468 D hypothetical protein 1558244..1558468 Streptococcus pneumoniae TIGR4 931181 NP_346097.1 CDS SP_1658 NC_003028.3 1558537 1558797 R hypothetical protein complement(1558537..1558797) Streptococcus pneumoniae TIGR4 931180 NP_346098.1 CDS ileS NC_003028.3 1559245 1562037 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase complement(1559245..1562037) Streptococcus pneumoniae TIGR4 931179 NP_346099.1 CDS SP_1660 NC_003028.3 1562181 1562342 R hypothetical protein complement(1562181..1562342) Streptococcus pneumoniae TIGR4 931176 NP_346100.1 CDS SP_1661 NC_003028.3 1562385 1563173 R similar to GP:4009475; identified by sequence similarity; cell division protein DivIVA complement(1562385..1563173) Streptococcus pneumoniae TIGR4 931174 NP_346101.1 CDS SP_1662 NC_003028.3 1563182 1563967 R hypothetical protein complement(1563182..1563967) Streptococcus pneumoniae TIGR4 931171 NP_346102.1 CDS SP_1663 NC_003028.3 1563964 1564227 R similar to GP:4009473; identified by sequence similarity; hypothetical protein complement(1563964..1564227) Streptococcus pneumoniae TIGR4 931170 NP_346103.1 CDS SP_1664 NC_003028.3 1564227 1564766 R similar to GP:4009472; identified by sequence similarity; hypothetical protein complement(1564227..1564766) Streptococcus pneumoniae TIGR4 931177 NP_346104.1 CDS SP_1665 NC_003028.3 1564776 1565447 R identified by match to PFAM protein family HMM PF01168; hypothetical protein complement(1564776..1565447) Streptococcus pneumoniae TIGR4 931157 NP_346105.1 CDS SP_1666 NC_003028.3 1565452 1566711 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(1565452..1566711) Streptococcus pneumoniae TIGR4 931159 NP_346106.1 CDS SP_1667 NC_003028.3 1566728 1568101 R identified by match to PFAM protein family HMM PF02491; cell division protein FtsA complement(1566728..1568101) Streptococcus pneumoniae TIGR4 931204 NP_346107.1 CDS SP_1668 NC_003028.3 1568320 1569024 R hypothetical protein complement(1568320..1569024) Streptococcus pneumoniae TIGR4 931169 NP_346108.1 CDS SP_1669 NC_003028.3 1569115 1569726 R MutT/nudix family protein complement(1569115..1569726) Streptococcus pneumoniae TIGR4 931168 NP_346109.1 CDS SP_1670 NC_003028.3 1569713 1571086 R identified by match to TIGR protein family HMM TIGR01143; UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase complement(1569713..1571086) Streptococcus pneumoniae TIGR4 931167 NP_346110.1 CDS ddl NC_003028.3 1571170 1572213 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(1571170..1572213) Streptococcus pneumoniae TIGR4 931166 NP_346111.1 CDS recR NC_003028.3 1572389 1572985 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(1572389..1572985) Streptococcus pneumoniae TIGR4 931165 NP_346112.1 CDS SP_1673 NC_003028.3 1572996 1575038 R penicillin-binding protein 2B complement(1572996..1575038) Streptococcus pneumoniae TIGR4 931164 NP_346113.1 CDS SP_1674 NC_003028.3 1575253 1576104 D phosphosugar-binding transcriptional regulator 1575253..1576104 Streptococcus pneumoniae TIGR4 931163 NP_346114.1 CDS SP_1675 NC_003028.3 1576120 1577004 R ROK family protein complement(1576120..1577004) Streptococcus pneumoniae TIGR4 931162 NP_346115.1 CDS SP_1676 NC_003028.3 1577022 1577939 R identified by match to PFAM protein family HMM PF00701; N-acetylneuraminate lyase complement(1577022..1577939) Streptococcus pneumoniae TIGR4 931161 NP_346116.1 CDS SP_1677 NC_003028.3 1578108 1578752 R hypothetical protein complement(1578108..1578752) Streptococcus pneumoniae TIGR4 931160 NP_346117.1 CDS SP_1678 NC_003028.3 1578734 1578832 R hypothetical protein complement(1578734..1578832) Streptococcus pneumoniae TIGR4 931156 NP_346118.1 CDS SP_1679 NC_003028.3 1579029 1579373 R hypothetical protein complement(1579029..1579373) Streptococcus pneumoniae TIGR4 931148 NP_346119.1 CDS SP_1680 NC_003028.3 1579470 1579922 R hypothetical protein complement(1579470..1579922) Streptococcus pneumoniae TIGR4 931152 NP_346120.1 CDS SP_1681 NC_003028.3 1580194 1581033 R sugar ABC transporter permease complement(1580194..1581033) Streptococcus pneumoniae TIGR4 931154 NP_346121.1 CDS SP_1682 NC_003028.3 1581049 1581945 R sugar ABC transporter permease complement(1581049..1581945) Streptococcus pneumoniae TIGR4 931155 NP_346122.1 CDS SP_1683 NC_003028.3 1582167 1583495 R sugar ABC transporter substrate-binding protein complement(1582167..1583495) Streptococcus pneumoniae TIGR4 931153 NP_346123.1 CDS SP_1684 NC_003028.3 1583620 1585137 R PTS system transporter subunit IIBC complement(1583620..1585137) Streptococcus pneumoniae TIGR4 931151 NP_346124.1 CDS SP_1685 NC_003028.3 1585156 1585854 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(1585156..1585854) Streptococcus pneumoniae TIGR4 931150 NP_346125.1 CDS SP_1686 NC_003028.3 1586028 1587131 R Gfo/Idh/MocA family oxidoreductase complement(1586028..1587131) Streptococcus pneumoniae TIGR4 931149 NP_346126.1 CDS SP_1687 NC_003028.3 1587143 1589236 R neuraminidase B complement(1587143..1589236) Streptococcus pneumoniae TIGR4 931147 NP_346127.1 CDS SP_1688 NC_003028.3 1589254 1590087 R ABC transporter permease complement(1589254..1590087) Streptococcus pneumoniae TIGR4 931134 NP_346128.1 CDS SP_1689 NC_003028.3 1590087 1590971 R ABC transporter permease complement(1590087..1590971) Streptococcus pneumoniae TIGR4 931140 NP_346129.1 CDS SP_1690 NC_003028.3 1591050 1592387 R ABC transporter substrate-binding protein complement(1591050..1592387) Streptococcus pneumoniae TIGR4 931141 NP_346130.1 CDS SP_1691 NC_003028.3 1592406 1592858 R hypothetical protein complement(1592406..1592858) Streptococcus pneumoniae TIGR4 931143 NP_346131.1 CDS SP_1692 NC_003028.3 1593972 1595228 D IS1167, transposase 1593972..1595228 Streptococcus pneumoniae TIGR4 931146 NP_346132.1 CDS SP_1694 NC_003028.3 1598470 1598697 R hypothetical protein complement(1598470..1598697) Streptococcus pneumoniae TIGR4 931144 NP_346133.1 CDS SP_1695 NC_003028.3 1599458 1600438 R similar to GP:7160626; identified by sequence similarity; acetyl xylan esterase complement(1599458..1600438) Streptococcus pneumoniae TIGR4 931142 NP_346134.1 CDS SP_1696 NC_003028.3 1600611 1600718 R hypothetical protein complement(1600611..1600718) Streptococcus pneumoniae TIGR4 931139 NP_346135.1 CDS SP_1697 NC_003028.3 1600953 1602968 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(1600953..1602968) Streptococcus pneumoniae TIGR4 931138 NP_346136.1 CDS alr NC_003028.3 1602987 1604090 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(1602987..1604090) Streptococcus pneumoniae TIGR4 931137 NP_346137.1 CDS acpS NC_003028.3 1604080 1604442 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(1604080..1604442) Streptococcus pneumoniae TIGR4 931136 NP_346138.1 CDS SP_1700 NC_003028.3 1604487 1605518 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1604487..1605518) Streptococcus pneumoniae TIGR4 931135 NP_346139.1 CDS SP_1701 NC_003028.3 1605520 1606551 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1605520..1606551) Streptococcus pneumoniae TIGR4 931132 NP_346140.1 CDS secA NC_003028.3 1606632 1609145 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(1606632..1609145) Streptococcus pneumoniae TIGR4 931130 NP_346141.1 CDS SP_1703 NC_003028.3 1609291 1609578 R similar to SP:Q09208 PID:643105; identified by sequence similarity; hypothetical protein complement(1609291..1609578) Streptococcus pneumoniae TIGR4 931129 NP_346142.1 CDS SP_1704 NC_003028.3 1609606 1610238 R ABC transporter ATP-binding protein complement(1609606..1610238) Streptococcus pneumoniae TIGR4 931128 NP_346143.1 CDS SP_1705 NC_003028.3 1610242 1610883 R hypothetical protein complement(1610242..1610883) Streptococcus pneumoniae TIGR4 931127 NP_346144.1 CDS SP_1706 NC_003028.3 1610876 1611667 R hypothetical protein complement(1610876..1611667) Streptococcus pneumoniae TIGR4 931126 NP_346145.1 CDS SP_1707 NC_003028.3 1611852 1612190 R hypothetical protein complement(1611852..1612190) Streptococcus pneumoniae TIGR4 931125 NP_346146.1 CDS SP_1708 NC_003028.3 1612327 1612671 R hypothetical protein complement(1612327..1612671) Streptococcus pneumoniae TIGR4 931124 NP_346147.1 CDS engA NC_003028.3 1612751 1614061 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(1612751..1614061) Streptococcus pneumoniae TIGR4 931123 NP_346148.1 CDS SP_1710 NC_003028.3 1614075 1614788 R identified by match to PFAM protein family HMM PF00881; nitroreductase complement(1614075..1614788) Streptococcus pneumoniae TIGR4 931122 NP_346149.1 CDS SP_1711 NC_003028.3 1614785 1615681 R Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI complement(1614785..1615681) Streptococcus pneumoniae TIGR4 931121 NP_346150.1 CDS SP_1712 NC_003028.3 1615682 1616851 R hypothetical protein complement(1615682..1616851) Streptococcus pneumoniae TIGR4 931120 NP_346151.1 CDS nrdR NC_003028.3 1616852 1617325 R transcriptional regulator NrdR complement(1616852..1617325) Streptococcus pneumoniae TIGR4 931119 NP_346152.1 CDS SP_1714 NC_003028.3 1617465 1617830 D GntR family transcriptional regulator 1617465..1617830 Streptococcus pneumoniae TIGR4 931118 NP_346153.1 CDS SP_1715 NC_003028.3 1617835 1619313 D hypothetical protein 1617835..1619313 Streptococcus pneumoniae TIGR4 931117 NP_346154.1 CDS SP_1716 NC_003028.3 1619725 1620924 R hypothetical protein complement(1619725..1620924) Streptococcus pneumoniae TIGR4 931116 NP_346155.1 CDS SP_1717 NC_003028.3 1620921 1621814 R ABC transporter ATP-binding protein complement(1620921..1621814) Streptococcus pneumoniae TIGR4 931115 NP_346156.1 CDS SP_1718 NC_003028.3 1622205 1622306 R hypothetical protein complement(1622205..1622306) Streptococcus pneumoniae TIGR4 931114 NP_346157.1 CDS SP_1720 NC_003028.3 1623130 1623747 D hypothetical protein 1623130..1623747 Streptococcus pneumoniae TIGR4 931112 NP_346158.1 CDS SP_1721 NC_003028.3 1624067 1624954 R fructokinase complement(1624067..1624954) Streptococcus pneumoniae TIGR4 931111 NP_346159.1 CDS SP_1722 NC_003028.3 1625103 1626986 R identified by match to PFAM protein family HMM PF02378; PTS system IIABC components complement(1625103..1626986) Streptococcus pneumoniae TIGR4 931110 NP_346160.1 CDS SP_1723 NC_003028.3 1627112 1627309 R hypothetical protein complement(1627112..1627309) Streptococcus pneumoniae TIGR4 931109 NP_346161.1 CDS SP_1724 NC_003028.3 1627362 1628816 D sucrose-6-phosphate hydrolase 1627362..1628816 Streptococcus pneumoniae TIGR4 931108 NP_346162.1 CDS SP_1725 NC_003028.3 1628797 1629762 D sucrose operon repressor 1628797..1629762 Streptococcus pneumoniae TIGR4 931107 NP_346163.1 CDS SP_1726 NC_003028.3 1629797 1631071 R identified by match to PFAM protein family HMM PF00368; 3-hydroxy-3-methylglutaryl-CoA reductase complement(1629797..1631071) Streptococcus pneumoniae TIGR4 931106 NP_346164.1 CDS SP_1727 NC_003028.3 1631071 1632267 R identified by match to PFAM protein family HMM PF01154; hydroxymethylglutaryl-CoA synthase complement(1631071..1632267) Streptococcus pneumoniae TIGR4 931105 NP_346165.1 CDS SP_1728 NC_003028.3 1632374 1632661 R hypothetical protein complement(1632374..1632661) Streptococcus pneumoniae TIGR4 931103 YP_873935.1 CDS SP_1729 NC_003028.3 1632690 1633310 R OrfA/OrfB; truncated IS1381 transposase complement(1632690..1633310) Streptococcus pneumoniae TIGR4 931104 NP_346166.1 CDS SP_1730 NC_003028.3 1633375 1633824 R hypothetical protein complement(1633375..1633824) Streptococcus pneumoniae TIGR4 931102 NP_346167.1 CDS SP_1731 NC_003028.3 1633826 1634584 R hypothetical protein complement(1633826..1634584) Streptococcus pneumoniae TIGR4 931100 NP_346168.1 CDS SP_1732 NC_003028.3 1634699 1636678 R serine/threonine protein kinase complement(1634699..1636678) Streptococcus pneumoniae TIGR4 931099 NP_346169.1 CDS SP_1733 NC_003028.3 1636675 1637415 R phosphatase complement(1636675..1637415) Streptococcus pneumoniae TIGR4 931178 NP_346170.1 CDS SP_1734 NC_003028.3 1637430 1638743 R identified by match to PFAM protein family HMM PF01029; rRNA methyltransferase RsmB complement(1637430..1638743) Streptococcus pneumoniae TIGR4 930635 NP_346171.1 CDS fmt NC_003028.3 1638736 1639671 R modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase complement(1638736..1639671) Streptococcus pneumoniae TIGR4 931089 NP_346172.1 CDS SP_1736 NC_003028.3 1639684 1642080 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(1639684..1642080) Streptococcus pneumoniae TIGR4 931098 NP_346173.1 CDS SP_1737 NC_003028.3 1642146 1642457 R Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(1642146..1642457) Streptococcus pneumoniae TIGR4 931097 NP_346174.1 CDS gmk NC_003028.3 1642485 1643111 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(1642485..1643111) Streptococcus pneumoniae TIGR4 931096 NP_346175.1 CDS SP_1739 NC_003028.3 1643241 1644845 R hypothetical protein complement(1643241..1644845) Streptococcus pneumoniae TIGR4 931095 NP_346176.1 CDS SP_1740 NC_003028.3 1645045 1645299 R hypothetical protein complement(1645045..1645299) Streptococcus pneumoniae TIGR4 931094 NP_346177.1 CDS SP_1741 NC_003028.3 1645303 1645557 R hypothetical protein complement(1645303..1645557) Streptococcus pneumoniae TIGR4 931093 NP_346178.1 CDS SP_1742 NC_003028.3 1645795 1646892 R hypothetical protein complement(1645795..1646892) Streptococcus pneumoniae TIGR4 931092 NP_346179.1 CDS SP_1743 NC_003028.3 1646902 1647648 R hypothetical protein complement(1646902..1647648) Streptococcus pneumoniae TIGR4 931091 NP_346180.1 CDS SP_1744 NC_003028.3 1647751 1648104 R iojap-like protein complement(1647751..1648104) Streptococcus pneumoniae TIGR4 931090 NP_346181.1 CDS SP_1745 NC_003028.3 1648117 1648617 R identified by match to PFAM protein family HMM PF00857; isochorismatase complement(1648117..1648617) Streptococcus pneumoniae TIGR4 931088 NP_346182.1 CDS SP_1746 NC_003028.3 1648618 1649211 R hypothetical protein complement(1648618..1649211) Streptococcus pneumoniae TIGR4 931087 NP_346183.1 CDS nadD NC_003028.3 1649211 1649840 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(1649211..1649840) Streptococcus pneumoniae TIGR4 931086 NP_346184.1 CDS SP_1748 NC_003028.3 1649892 1650203 R hypothetical protein complement(1649892..1650203) Streptococcus pneumoniae TIGR4 931085 NP_346185.1 CDS SP_1749 NC_003028.3 1650417 1651523 R in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH complement(1650417..1651523) Streptococcus pneumoniae TIGR4 931084 NP_346186.1 CDS SP_1750 NC_003028.3 1651526 1652053 R hypothetical protein complement(1651526..1652053) Streptococcus pneumoniae TIGR4 931083 NP_346187.1 CDS SP_1751 NC_003028.3 1652068 1652976 R identified by match to PFAM protein family HMM PF01544; magnesium/cobalt transporter CorA complement(1652068..1652976) Streptococcus pneumoniae TIGR4 931082 NP_346188.1 CDS SP_1752 NC_003028.3 1653033 1653638 R identified by match to PFAM protein family HMM PF00924; mechanosensitive ion channel MscS complement(1653033..1653638) Streptococcus pneumoniae TIGR4 931081 NP_346189.1 CDS SP_1754 NC_003028.3 1655009 1655962 D hypothetical protein 1655009..1655962 Streptococcus pneumoniae TIGR4 931078 NP_346190.1 CDS SP_1755 NC_003028.3 1656378 1656602 R hypothetical protein complement(1656378..1656602) Streptococcus pneumoniae TIGR4 931079 NP_346191.1 CDS SP_1756 NC_003028.3 1656607 1656786 R similar to GB:AE000657; identified by sequence similarity; hypothetical protein complement(1656607..1656786) Streptococcus pneumoniae TIGR4 931077 NP_346192.1 CDS SP_1757 NC_003028.3 1656788 1658125 R hypothetical protein complement(1656788..1658125) Streptococcus pneumoniae TIGR4 931076 NP_346193.1 CDS SP_1758 NC_003028.3 1658118 1659629 R group 1 glycosyl transferase complement(1658118..1659629) Streptococcus pneumoniae TIGR4 931075 NP_346194.1 CDS SP_1759 NC_003028.3 1659641 1662013 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins; preprotein translocase subunit SecA complement(1659641..1662013) Streptococcus pneumoniae TIGR4 931074 NP_346195.1 CDS SP_1760 NC_003028.3 1662006 1662446 R similar to SP:P39684 PID:836778; identified by sequence similarity; hypothetical protein complement(1662006..1662446) Streptococcus pneumoniae TIGR4 931073 NP_346196.1 CDS SP_1761 NC_003028.3 1662443 1663978 R hypothetical protein complement(1662443..1663978) Streptococcus pneumoniae TIGR4 931072 NP_346197.1 CDS SP_1762 NC_003028.3 1663962 1665542 R hypothetical protein complement(1663962..1665542) Streptococcus pneumoniae TIGR4 931071 NP_346198.1 CDS secY NC_003028.3 1665552 1666769 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(1665552..1666769) Streptococcus pneumoniae TIGR4 931070 NP_346199.1 CDS SP_1764 NC_003028.3 1666826 1667731 R glycosyl transferase family protein complement(1666826..1667731) Streptococcus pneumoniae TIGR4 931069 NP_346200.1 CDS SP_1765 NC_003028.3 1667731 1668927 R identified by match to PFAM protein family HMM PF01501; glycosyl transferase family protein complement(1667731..1668927) Streptococcus pneumoniae TIGR4 931068 NP_346201.1 CDS SP_1766 NC_003028.3 1668936 1670156 R identified by match to PFAM protein family HMM PF01501; glycosyl transferase family protein complement(1668936..1670156) Streptococcus pneumoniae TIGR4 931067 NP_346202.1 CDS SP_1767 NC_003028.3 1670187 1672631 R identified by match to PFAM protein family HMM PF01501; glycosyl transferase family protein complement(1670187..1672631) Streptococcus pneumoniae TIGR4 931066 NP_346203.1 CDS SP_1768 NC_003028.3 1672641 1673651 R hypothetical protein complement(1672641..1673651) Streptococcus pneumoniae TIGR4 931065 NP_346204.1 CDS SP_1770 NC_003028.3 1674561 1675775 R identified by match to PFAM protein family HMM PF01501; glycosyl transferase family protein complement(1674561..1675775) Streptococcus pneumoniae TIGR4 931052 NP_346205.1 CDS SP_1771 NC_003028.3 1676082 1678172 R identified by match to PFAM protein family HMM PF01501; glycosyl transferase family protein complement(1676082..1678172) Streptococcus pneumoniae TIGR4 931055 NP_346206.1 CDS SP_1772 NC_003028.3 1678227 1692557 R identified by match to PFAM protein family HMM PF00746; cell wall surface anchor family protein complement(1678227..1692557) Streptococcus pneumoniae TIGR4 931060 NP_346207.1 CDS SP_1774 NC_003028.3 1693715 1694176 D transcriptional regulator 1693715..1694176 Streptococcus pneumoniae TIGR4 931062 NP_346208.1 CDS SP_1775 NC_003028.3 1694194 1694496 D similar to GP:3980554; identified by sequence similarity; hypothetical protein 1694194..1694496 Streptococcus pneumoniae TIGR4 931061 NP_346209.1 CDS SP_1776 NC_003028.3 1694513 1694827 D thioredoxin 1694513..1694827 Streptococcus pneumoniae TIGR4 931059 NP_346210.1 CDS SP_1777 NC_003028.3 1695201 1695665 D NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 1695201..1695665 Streptococcus pneumoniae TIGR4 931058 NP_346211.1 CDS SP_1778 NC_003028.3 1696189 1696857 R identified by match to PFAM protein family HMM PF00230; aquaporin complement(1696189..1696857) Streptococcus pneumoniae TIGR4 931056 NP_346212.1 CDS SP_1779 NC_003028.3 1696968 1697528 R hypothetical protein complement(1696968..1697528) Streptococcus pneumoniae TIGR4 931057 NP_346213.1 CDS SP_1780 NC_003028.3 1697768 1699564 R identified by match to PFAM protein family HMM PF01432; oligoendopeptidase F complement(1697768..1699564) Streptococcus pneumoniae TIGR4 931054 NP_346214.1 CDS SP_1781 NC_003028.3 1699575 1700318 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(1699575..1700318) Streptococcus pneumoniae TIGR4 931053 NP_346215.1 CDS prmA NC_003028.3 1700320 1701270 R methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase complement(1700320..1701270) Streptococcus pneumoniae TIGR4 931051 NP_346216.1 CDS SP_1783 NC_003028.3 1701406 1701834 R MutT/nudix family protein complement(1701406..1701834) Streptococcus pneumoniae TIGR4 931050 NP_346217.1 CDS SP_1784 NC_003028.3 1701815 1702903 R hypothetical protein complement(1701815..1702903) Streptococcus pneumoniae TIGR4 931049 NP_346218.1 CDS SP_1785 NC_003028.3 1702922 1703392 R hypothetical protein complement(1702922..1703392) Streptococcus pneumoniae TIGR4 931048 NP_346219.1 CDS SP_1786 NC_003028.3 1703683 1704135 R hypothetical protein complement(1703683..1704135) Streptococcus pneumoniae TIGR4 931047 NP_346220.1 CDS SP_1787 NC_003028.3 1704172 1704378 R hypothetical protein complement(1704172..1704378) Streptococcus pneumoniae TIGR4 931046 NP_346221.1 CDS SP_1788 NC_003028.3 1704738 1704842 R hypothetical protein complement(1704738..1704842) Streptococcus pneumoniae TIGR4 931045 NP_346222.1 CDS SP_1789 NC_003028.3 1704832 1705053 R hypothetical protein complement(1704832..1705053) Streptococcus pneumoniae TIGR4 931042 NP_346223.1 CDS SP_1790 NC_003028.3 1705345 1706616 D recombination factor protein RarA 1705345..1706616 Streptococcus pneumoniae TIGR4 931043 NP_346224.1 CDS SP_1791 NC_003028.3 1707036 1707152 R similar to GP:758229; identified by sequence similarity; integrase-like protein complement(1707036..1707152) Streptococcus pneumoniae TIGR4 931041 NP_346225.1 CDS SP_1792 NC_003028.3 1707173 1708429 R IS1167, transposase complement(1707173..1708429) Streptococcus pneumoniae TIGR4 931040 NP_346226.1 CDS SP_1793 NC_003028.3 1708735 1709310 R hypothetical protein complement(1708735..1709310) Streptococcus pneumoniae TIGR4 931039 NP_346227.1 CDS SP_1794 NC_003028.3 1709561 1709986 R hypothetical protein complement(1709561..1709986) Streptococcus pneumoniae TIGR4 931038 NP_346228.1 CDS SP_1795 NC_003028.3 1710372 1711691 R sucrose-6-phosphate hydrolase complement(1710372..1711691) Streptococcus pneumoniae TIGR4 931037 NP_346229.1 CDS SP_1796 NC_003028.3 1711701 1713317 R ABC transporter substrate-binding protein complement(1711701..1713317) Streptococcus pneumoniae TIGR4 931036 NP_346230.1 CDS SP_1797 NC_003028.3 1713346 1714263 R ABC transporter permease complement(1713346..1714263) Streptococcus pneumoniae TIGR4 930997 NP_346231.1 CDS SP_1798 NC_003028.3 1714247 1715164 R ABC transporter permease complement(1714247..1715164) Streptococcus pneumoniae TIGR4 931001 NP_346232.1 CDS SP_1799 NC_003028.3 1715315 1716316 R LacI family transcriptional regulator complement(1715315..1716316) Streptococcus pneumoniae TIGR4 931002 NP_346233.1 CDS SP_1800 NC_003028.3 1716678 1718159 R similar to GP:409925; identified by sequence similarity; transcriptional activator complement(1716678..1718159) Streptococcus pneumoniae TIGR4 931019 NP_346234.1 CDS SP_1801 NC_003028.3 1718602 1718766 D hypothetical protein 1718602..1718766 Streptococcus pneumoniae TIGR4 931035 NP_346235.1 CDS SP_1802 NC_003028.3 1718844 1719416 D hypothetical protein 1718844..1719416 Streptococcus pneumoniae TIGR4 931034 NP_346236.1 CDS SP_1803 NC_003028.3 1719428 1719598 D hypothetical protein 1719428..1719598 Streptococcus pneumoniae TIGR4 931033 NP_346237.1 CDS SP_1804 NC_003028.3 1719637 1720245 D similar to PID:2274940; identified by sequence similarity; general stress protein 24 1719637..1720245 Streptococcus pneumoniae TIGR4 931032 NP_346238.1 CDS SP_1805 NC_003028.3 1720276 1720479 D hypothetical protein 1720276..1720479 Streptococcus pneumoniae TIGR4 931031 NP_346239.1 CDS SP_1806 NC_003028.3 1720589 1720828 R similar to GP:8918792; identified by sequence similarity; hypothetical protein complement(1720589..1720828) Streptococcus pneumoniae TIGR4 931030 NP_346240.1 CDS SP_1807 NC_003028.3 1721006 1721452 R acetyltransferase complement(1721006..1721452) Streptococcus pneumoniae TIGR4 931029 NP_346241.1 CDS SP_1808 NC_003028.3 1721522 1722181 D identified by match to PFAM protein family HMM PF01478; type IV prepilin peptidase 1721522..1722181 Streptococcus pneumoniae TIGR4 931028 NP_346242.1 CDS SP_1809 NC_003028.3 1722233 1723384 R transcriptional regulator complement(1722233..1723384) Streptococcus pneumoniae TIGR4 931026 NP_346243.1 CDS SP_1810 NC_003028.3 1723399 1724130 R hypothetical protein complement(1723399..1724130) Streptococcus pneumoniae TIGR4 931027 NP_346244.1 CDS trpA NC_003028.3 1724432 1725208 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1724432..1725208) Streptococcus pneumoniae TIGR4 931025 NP_346245.1 CDS SP_1812 NC_003028.3 1725201 1726424 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1725201..1726424) Streptococcus pneumoniae TIGR4 931024 NP_346246.1 CDS SP_1813 NC_003028.3 1726402 1727001 R catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase complement(1726402..1727001) Streptococcus pneumoniae TIGR4 931023 NP_346247.1 CDS trpC NC_003028.3 1726988 1727755 R involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol phosphate synthase complement(1726988..1727755) Streptococcus pneumoniae TIGR4 931022 NP_346248.1 CDS trpD NC_003028.3 1727752 1728756 R Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase complement(1727752..1728756) Streptococcus pneumoniae TIGR4 931021 NP_346249.1 CDS SP_1816 NC_003028.3 1728767 1729333 R TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II complement(1728767..1729333) Streptococcus pneumoniae TIGR4 931020 NP_346250.1 CDS SP_1817 NC_003028.3 1729330 1730691 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1729330..1730691) Streptococcus pneumoniae TIGR4 931018 NP_346251.1 CDS SP_1818 NC_003028.3 1730869 1731051 D hypothetical protein 1730869..1731051 Streptococcus pneumoniae TIGR4 931017 NP_346252.1 CDS SP_1819 NC_003028.3 1731356 1731451 R hypothetical protein complement(1731356..1731451) Streptococcus pneumoniae TIGR4 931016 NP_346253.1 CDS SP_1820 NC_003028.3 1731458 1731553 R hypothetical protein complement(1731458..1731553) Streptococcus pneumoniae TIGR4 931015 NP_346254.1 CDS SP_1821 NC_003028.3 1731967 1732968 R LacI family transcriptional regulator complement(1731967..1732968) Streptococcus pneumoniae TIGR4 931014 NP_346255.1 CDS SP_1822 NC_003028.3 1733076 1733444 R similar to GP:4514548; identified by sequence similarity; hypothetical protein complement(1733076..1733444) Streptococcus pneumoniae TIGR4 931013 NP_346256.1 CDS SP_1823 NC_003028.3 1733540 1734250 R MgtC/SapB family protein complement(1733540..1734250) Streptococcus pneumoniae TIGR4 931012 NP_346257.1 CDS SP_1824 NC_003028.3 1734253 1735944 R ABC transporter permease complement(1734253..1735944) Streptococcus pneumoniae TIGR4 931011 NP_346258.1 CDS SP_1825 NC_003028.3 1735956 1736966 R ABC transporter ATP-binding protein complement(1735956..1736966) Streptococcus pneumoniae TIGR4 931010 NP_346259.1 CDS SP_1826 NC_003028.3 1737069 1738136 R ABC transporter substrate-binding protein complement(1737069..1738136) Streptococcus pneumoniae TIGR4 931009 NP_346260.1 CDS SP_1827 NC_003028.3 1738161 1738820 R hypothetical protein complement(1738161..1738820) Streptococcus pneumoniae TIGR4 931008 NP_346261.1 CDS SP_1828 NC_003028.3 1739000 1740010 R identified by match to TIGR protein family HMM TIGR01179; UDP-glucose 4-epimerase complement(1739000..1740010) Streptococcus pneumoniae TIGR4 931007 NP_346262.1 CDS SP_1829 NC_003028.3 1740023 1741498 R catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase complement(1740023..1741498) Streptococcus pneumoniae TIGR4 931006 NP_346263.1 CDS SP_1830 NC_003028.3 1741511 1742152 R similar to GP:4530451; identified by sequence similarity; phosphate transport system regulatory protein PhoU complement(1741511..1742152) Streptococcus pneumoniae TIGR4 931005 NP_346264.1 CDS SP_1831 NC_003028.3 1742210 1742692 R hypothetical protein complement(1742210..1742692) Streptococcus pneumoniae TIGR4 931004 NP_346265.1 CDS SP_1832 NC_003028.3 1742753 1743049 R hypothetical protein complement(1742753..1743049) Streptococcus pneumoniae TIGR4 931003 NP_346266.1 CDS SP_1833 NC_003028.3 1743033 1745159 R cell wall surface anchor family protein complement(1743033..1745159) Streptococcus pneumoniae TIGR4 931000 NP_346267.1 CDS SP_1834 NC_003028.3 1745472 1745702 R hypothetical protein complement(1745472..1745702) Streptococcus pneumoniae TIGR4 930999 NP_346268.1 CDS SP_1835 NC_003028.3 1745913 1746038 R hypothetical protein complement(1745913..1746038) Streptococcus pneumoniae TIGR4 930998 NP_346269.1 CDS SP_1836 NC_003028.3 1746104 1746280 D hypothetical protein 1746104..1746280 Streptococcus pneumoniae TIGR4 930996 NP_346270.1 CDS SP_1837 NC_003028.3 1746322 1747548 R identified by match to PFAM protein family HMM PF01041; capsular polysaccharide biosynthesis protein complement(1746322..1747548) Streptococcus pneumoniae TIGR4 930995 NP_346271.1 CDS SP_1838 NC_003028.3 1747591 1748283 R identified by match to PFAM protein family HMM PF02397; glycosyl transferase family protein complement(1747591..1748283) Streptococcus pneumoniae TIGR4 930994 NP_346272.1 CDS SP_1839 NC_003028.3 1748456 1750207 R ABC transporter ATP-binding protein/permease complement(1748456..1750207) Streptococcus pneumoniae TIGR4 930993 NP_346273.1 CDS SP_1840 NC_003028.3 1750197 1751942 R ABC transporter ATP-binding protein/permease complement(1750197..1751942) Streptococcus pneumoniae TIGR4 930992 NP_346274.1 CDS SP_1841 NC_003028.3 1752148 1752525 R similar to GB:AL009126; identified by sequence similarity; hypothetical protein complement(1752148..1752525) Streptococcus pneumoniae TIGR4 930991 NP_346275.1 CDS SP_1842 NC_003028.3 1752597 1752710 R hypothetical protein complement(1752597..1752710) Streptococcus pneumoniae TIGR4 930990 NP_346276.1 CDS SP_1843 NC_003028.3 1752771 1752866 R hypothetical protein complement(1752771..1752866) Streptococcus pneumoniae TIGR4 930989 NP_346277.1 CDS SP_1844 NC_003028.3 1752826 1753053 R hypothetical protein complement(1752826..1753053) Streptococcus pneumoniae TIGR4 930988 NP_346278.1 CDS SP_1845 NC_003028.3 1753187 1754014 D identified by match to PFAM protein family HMM PF01260; exodeoxyribonuclease 1753187..1754014 Streptococcus pneumoniae TIGR4 930987 NP_346279.1 CDS SP_1847 NC_003028.3 1755277 1755858 D Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 1755277..1755858 Streptococcus pneumoniae TIGR4 930985 NP_346280.1 CDS SP_1848 NC_003028.3 1755858 1757120 D xanthine permease 1755858..1757120 Streptococcus pneumoniae TIGR4 930984 NP_346281.1 CDS SP_1849 NC_003028.3 1757170 1757631 R similar to GB:M14340 SP:P09359 GB:S56948 PID:153607; identified by sequence similarity; DpnD protein complement(1757170..1757631) Streptococcus pneumoniae TIGR4 930973 NP_346282.1 CDS SP_1850 NC_003028.3 1757628 1758392 R similar to SP:P09356 GB:S56948 PID:153606; identified by sequence similarity; type II restriction endonuclease DpnI complement(1757628..1758392) Streptococcus pneumoniae TIGR4 930966 NP_346283.1 CDS SP_1851 NC_003028.3 1758573 1758977 R hypothetical protein complement(1758573..1758977) Streptococcus pneumoniae TIGR4 930982 NP_346284.1 CDS SP_1852 NC_003028.3 1759048 1760529 R catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase complement(1759048..1760529) Streptococcus pneumoniae TIGR4 930983 NP_346285.1 CDS SP_1853 NC_003028.3 1760548 1761726 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(1760548..1761726) Streptococcus pneumoniae TIGR4 930981 NP_346286.1 CDS SP_1854 NC_003028.3 1761891 1762898 D galactose operon repressor 1761891..1762898 Streptococcus pneumoniae TIGR4 930980 NP_346287.1 CDS SP_1855 NC_003028.3 1762944 1763981 R zinc-containing alcohol dehydrogenase complement(1762944..1763981) Streptococcus pneumoniae TIGR4 930979 NP_346288.1 CDS SP_1856 NC_003028.3 1763982 1764335 R MerR family transcriptional regulator complement(1763982..1764335) Streptococcus pneumoniae TIGR4 930978 NP_346289.1 CDS SP_1857 NC_003028.3 1764579 1765478 R identified by match to PFAM protein family HMM PF01545; cation efflux system protein complement(1764579..1765478) Streptococcus pneumoniae TIGR4 930977 NP_346290.1 CDS SP_1858 NC_003028.3 1765602 1766138 D TetR family transcriptional regulator 1765602..1766138 Streptococcus pneumoniae TIGR4 930976 NP_346291.1 CDS SP_1859 NC_003028.3 1766305 1767114 R similar to GB:L42023 PID:1161423 PID:1221194 PID:1205327 SP:Q57425; identified by sequence similarity; transporter complement(1766305..1767114) Streptococcus pneumoniae TIGR4 930975 NP_346292.1 CDS SP_1860 NC_003028.3 1767456 1768976 R choline transporter complement(1767456..1768976) Streptococcus pneumoniae TIGR4 930974 NP_346293.1 CDS SP_1861 NC_003028.3 1768969 1769697 R choline transporter complement(1768969..1769697) Streptococcus pneumoniae TIGR4 930972 NP_346294.1 CDS SP_1862 NC_003028.3 1769712 1770476 R hypothetical protein complement(1769712..1770476) Streptococcus pneumoniae TIGR4 930970 NP_346295.1 CDS SP_1863 NC_003028.3 1770480 1770923 R MarR family transcriptional regulator complement(1770480..1770923) Streptococcus pneumoniae TIGR4 930971 NP_346296.1 CDS SP_1864 NC_003028.3 1771605 1771901 R hypothetical protein complement(1771605..1771901) Streptococcus pneumoniae TIGR4 930969 NP_346297.1 CDS SP_1865 NC_003028.3 1771923 1772987 R glutamyl-aminopeptidase complement(1771923..1772987) Streptococcus pneumoniae TIGR4 930968 NP_346298.1 CDS SP_1866 NC_003028.3 1773107 1773229 D hypothetical protein 1773107..1773229 Streptococcus pneumoniae TIGR4 930967 NP_346299.1 CDS SP_1867 NC_003028.3 1773388 1774089 D NAD-dependent epimerase/dehydratase 1773388..1774089 Streptococcus pneumoniae TIGR4 930965 NP_346300.1 CDS SP_1868 NC_003028.3 1774105 1774215 D similar to PID:1652006; identified by sequence similarity; hypothetical protein 1774105..1774215 Streptococcus pneumoniae TIGR4 930955 NP_346301.1 CDS SP_1869 NC_003028.3 1774497 1775471 D identified by match to PFAM protein family HMM PF01032; iron ABC transporter permease 1774497..1775471 Streptococcus pneumoniae TIGR4 930959 NP_346302.1 CDS SP_1870 NC_003028.3 1775461 1776417 D identified by match to PFAM protein family HMM PF01032; iron ABC transporter permease 1775461..1776417 Streptococcus pneumoniae TIGR4 930962 NP_346303.1 CDS SP_1871 NC_003028.3 1776414 1777166 D iron-compound ABC transporter ATP-binding protein 1776414..1777166 Streptococcus pneumoniae TIGR4 930964 NP_346304.1 CDS SP_1872 NC_003028.3 1777262 1778227 D iron-compound ABC transporter iron-compound-binding protein 1777262..1778227 Streptococcus pneumoniae TIGR4 930963 NP_346305.1 CDS SP_1873 NC_003028.3 1778452 1778694 R hypothetical protein complement(1778452..1778694) Streptococcus pneumoniae TIGR4 930961 NP_346306.1 CDS SP_1874 NC_003028.3 1778694 1779416 R ribosomal large subunit pseudouridine synthase B complement(1778694..1779416) Streptococcus pneumoniae TIGR4 930960 NP_346307.1 CDS scpB NC_003028.3 1779403 1779972 R functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B complement(1779403..1779972) Streptococcus pneumoniae TIGR4 930958 NP_346308.1 CDS scpA NC_003028.3 1779991 1780719 R functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A complement(1779991..1780719) Streptococcus pneumoniae TIGR4 930957 NP_346309.1 CDS xerD NC_003028.3 1780719 1781459 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD complement(1780719..1781459) Streptococcus pneumoniae TIGR4 930956 NP_346310.1 CDS SP_1878 NC_003028.3 1781450 1781911 R hypothetical protein complement(1781450..1781911) Streptococcus pneumoniae TIGR4 930954 NP_346311.1 CDS SP_1879 NC_003028.3 1781908 1782429 R hypothetical protein complement(1781908..1782429) Streptococcus pneumoniae TIGR4 930953 NP_346312.3 CDS SP_1880 NC_003028.3 1782405 1783007 R HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein complement(1782405..1783007) Streptococcus pneumoniae TIGR4 930952 NP_346313.1 CDS SP_1881 NC_003028.3 1783373 1784167 R converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase complement(1783373..1784167) Streptococcus pneumoniae TIGR4 930951 NP_346314.1 CDS SP_1882 NC_003028.3 1784375 1784623 R hypothetical protein complement(1784375..1784623) Streptococcus pneumoniae TIGR4 930950 NP_346315.1 CDS SP_1883 NC_003028.3 1784879 1786504 R dextran glucosidase DexS complement(1784879..1786504) Streptococcus pneumoniae TIGR4 930949 NP_346316.1 CDS SP_1884 NC_003028.3 1786682 1788649 R trehalose PTS system, IIABC components complement(1786682..1788649) Streptococcus pneumoniae TIGR4 930948 NP_346317.1 CDS SP_1885 NC_003028.3 1788834 1789544 D trehalose operon transcriptional repressor 1788834..1789544 Streptococcus pneumoniae TIGR4 930947 NP_346318.1 CDS SP_1887 NC_003028.3 1791100 1792026 R oligopeptide ABC transporter ATP-binding protein AmiF complement(1791100..1792026) Streptococcus pneumoniae TIGR4 930945 NP_346319.1 CDS SP_1888 NC_003028.3 1792037 1793104 R oligopeptide ABC transporter ATP-binding protein AmiE complement(1792037..1793104) Streptococcus pneumoniae TIGR4 930944 NP_346320.1 CDS SP_1889 NC_003028.3 1793113 1794039 R oligopeptide ABC transporter permease AmiD complement(1793113..1794039) Streptococcus pneumoniae TIGR4 930933 NP_346321.1 CDS SP_1890 NC_003028.3 1794039 1795535 R oligopeptide ABC transporter permease AmiC complement(1794039..1795535) Streptococcus pneumoniae TIGR4 930941 NP_346322.1 CDS SP_1891 NC_003028.3 1795602 1797581 R oligopeptide ABC transporter oligopeptide-binding protein AmiA complement(1795602..1797581) Streptococcus pneumoniae TIGR4 930943 NP_346323.1 CDS SP_1892 NC_003028.3 1797708 1797875 D hypothetical protein 1797708..1797875 Streptococcus pneumoniae TIGR4 930942 NP_346324.1 CDS SP_1893 NC_003028.3 1798266 1799459 R hypothetical protein complement(1798266..1799459) Streptococcus pneumoniae TIGR4 930940 NP_346325.1 CDS SP_1894 NC_003028.3 1799597 1801039 R sucrose phosphorylase complement(1799597..1801039) Streptococcus pneumoniae TIGR4 930939 NP_346326.1 CDS SP_1895 NC_003028.3 1801397 1802233 R sugar ABC transporter permease complement(1801397..1802233) Streptococcus pneumoniae TIGR4 930938 NP_346327.1 CDS SP_1896 NC_003028.3 1802244 1803134 R sugar ABC transporter permease complement(1802244..1803134) Streptococcus pneumoniae TIGR4 930937 NP_346328.1 CDS SP_1897 NC_003028.3 1803124 1804383 R sugar ABC transporter substrate-binding protein complement(1803124..1804383) Streptococcus pneumoniae TIGR4 930936 NP_346329.1 CDS SP_1898 NC_003028.3 1804475 1806637 R similar to GB:M77351 SP:P27756 PID:153736; identified by sequence similarity; alpha-galactosidase complement(1804475..1806637) Streptococcus pneumoniae TIGR4 930935 NP_346330.1 CDS SP_1899 NC_003028.3 1806745 1807605 D msm operon regulatory protein 1806745..1807605 Streptococcus pneumoniae TIGR4 930934 NP_346331.1 CDS SP_1900 NC_003028.3 1807602 1808537 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1807602..1808537 Streptococcus pneumoniae TIGR4 930932 NP_346332.1 CDS SP_1901 NC_003028.3 1815445 1816755 R RNA methyltransferase complement(1815445..1816755) Streptococcus pneumoniae TIGR4 932014 NP_346333.1 CDS recX NC_003028.3 1816838 1817614 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1816838..1817614 Streptococcus pneumoniae TIGR4 932013 NP_346334.1 CDS SP_1903 NC_003028.3 1817703 1818236 D hypothetical protein 1817703..1818236 Streptococcus pneumoniae TIGR4 929755 NP_346335.1 CDS SP_1904 NC_003028.3 1818590 1818796 R hypothetical protein complement(1818590..1818796) Streptococcus pneumoniae TIGR4 929847 NP_346336.1 CDS groEL NC_003028.3 1820362 1821984 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL complement(1820362..1821984) Streptococcus pneumoniae TIGR4 931987 NP_346337.1 CDS groES NC_003028.3 1822000 1822284 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(1822000..1822284) Streptococcus pneumoniae TIGR4 929944 YP_873936.1 CDS SP_1908 NC_003028.3 1822440 1822835 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1822440..1822835) Streptococcus pneumoniae TIGR4 930149 NP_346338.1 CDS SP_1909 NC_003028.3 1822913 1823674 R short chain dehydrogenase/reductase family oxidoreductase complement(1822913..1823674) Streptococcus pneumoniae TIGR4 929802 NP_346339.1 CDS SP_1910 NC_003028.3 1823716 1824342 R hypothetical protein complement(1823716..1824342) Streptococcus pneumoniae TIGR4 930140 NP_346340.1 CDS SP_1911 NC_003028.3 1824358 1824675 R similar to SP:P29449 PID:20047; identified by sequence similarity; thioredoxin complement(1824358..1824675) Streptococcus pneumoniae TIGR4 930223 NP_346341.1 CDS SP_1912 NC_003028.3 1824672 1824971 R hypothetical protein complement(1824672..1824971) Streptococcus pneumoniae TIGR4 931950 NP_346342.1 CDS SP_1914 NC_003028.3 1825660 1826334 R hypothetical protein complement(1825660..1826334) Streptococcus pneumoniae TIGR4 930527 NP_346343.1 CDS SP_1915 NC_003028.3 1826340 1826789 R hypothetical protein complement(1826340..1826789) Streptococcus pneumoniae TIGR4 929971 NP_346344.1 CDS SP_1916 NC_003028.3 1826900 1827403 R identified by match to PFAM protein family HMM PF01569; PAP2 family protein complement(1826900..1827403) Streptococcus pneumoniae TIGR4 931899 NP_346345.1 CDS SP_1917 NC_003028.3 1827400 1827762 R hypothetical protein complement(1827400..1827762) Streptococcus pneumoniae TIGR4 930462 NP_346346.1 CDS SP_1918 NC_003028.3 1827828 1828859 R ABC transporter ATP-binding protein complement(1827828..1828859) Streptococcus pneumoniae TIGR4 931990 NP_346347.1 CDS SP_1919 NC_003028.3 1828866 1829687 R ABC transporter permease complement(1828866..1829687) Streptococcus pneumoniae TIGR4 930135 NP_346348.1 CDS SP_1920 NC_003028.3 1829726 1830175 R MarR family transcriptional regulator complement(1829726..1830175) Streptococcus pneumoniae TIGR4 930096 NP_346349.1 CDS SP_1921 NC_003028.3 1830188 1830283 R hypothetical protein complement(1830188..1830283) Streptococcus pneumoniae TIGR4 931844 NP_346350.1 CDS SP_1922 NC_003028.3 1830299 1831015 R hypothetical protein complement(1830299..1831015) Streptococcus pneumoniae TIGR4 930148 NP_346351.1 CDS SP_1923 NC_003028.3 1831896 1833311 R identified by match to PFAM protein family HMM PF01289; pneumolysin complement(1831896..1833311) Streptococcus pneumoniae TIGR4 931915 NP_346352.1 CDS SP_1924 NC_003028.3 1833322 1833732 R hypothetical protein complement(1833322..1833732) Streptococcus pneumoniae TIGR4 929813 NP_346353.1 CDS SP_1925 NC_003028.3 1833725 1834333 R hypothetical protein complement(1833725..1834333) Streptococcus pneumoniae TIGR4 931877 NP_346354.1 CDS SP_1926 NC_003028.3 1834346 1834822 R hypothetical protein complement(1834346..1834822) Streptococcus pneumoniae TIGR4 930085 NP_346355.1 CDS SP_1927 NC_003028.3 1834929 1835318 D similar to PID:763133; identified by sequence similarity; IS1381 transposase protein A 1834929..1835318 Streptococcus pneumoniae TIGR4 931475 NP_346356.1 CDS SP_1928 NC_003028.3 1835344 1835733 D similar to PID:763133; identified by sequence similarity; IS1381 transposase protein B 1835344..1835733 Streptococcus pneumoniae TIGR4 929822 NP_346357.1 CDS SP_1929 NC_003028.3 1836144 1836242 R hypothetical protein complement(1836144..1836242) Streptococcus pneumoniae TIGR4 931880 NP_346358.1 CDS SP_1930 NC_003028.3 1836471 1836731 R hypothetical protein complement(1836471..1836731) Streptococcus pneumoniae TIGR4 930313 NP_346359.1 CDS SP_1931 NC_003028.3 1836790 1837344 R hypothetical protein complement(1836790..1837344) Streptococcus pneumoniae TIGR4 930543 NP_346360.1 CDS SP_1932 NC_003028.3 1837331 1837429 R hypothetical protein complement(1837331..1837429) Streptococcus pneumoniae TIGR4 930252 NP_346361.1 CDS SP_1933 NC_003028.3 1837532 1838326 R hypothetical protein complement(1837532..1838326) Streptococcus pneumoniae TIGR4 930458 NP_346362.1 CDS SP_1934 NC_003028.3 1838734 1839159 R hypothetical protein complement(1838734..1839159) Streptococcus pneumoniae TIGR4 931989 NP_346363.1 CDS SP_1935 NC_003028.3 1839288 1839647 R hypothetical protein complement(1839288..1839647) Streptococcus pneumoniae TIGR4 931834 NP_346364.1 CDS SP_1936 NC_003028.3 1839886 1840047 R similar to GB:M77223 PID:455322; identified by sequence similarity; type II restriction-modification system regulatory protein complement(1839886..1840047) Streptococcus pneumoniae TIGR4 930503 NP_346365.1 CDS SP_1937 NC_003028.3 1840405 1841361 R identified by match to PFAM protein family HMM PF01510; autolysin complement(1840405..1841361) Streptococcus pneumoniae TIGR4 931994 NP_346366.1 CDS SP_1938 NC_003028.3 1841489 1841602 R hypothetical protein complement(1841489..1841602) Streptococcus pneumoniae TIGR4 930339 NP_346367.1 CDS SP_1939 NC_003028.3 1841737 1843107 R identified by match to PFAM protein family HMM PF01554; MATE efflux family protein DinF complement(1841737..1843107) Streptococcus pneumoniae TIGR4 931984 NP_346368.1 CDS recA NC_003028.3 1843413 1844579 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(1843413..1844579) Streptococcus pneumoniae TIGR4 929833 NP_346369.1 CDS SP_1941 NC_003028.3 1844634 1845890 R competence damage-inducible protein A complement(1844634..1845890) Streptococcus pneumoniae TIGR4 931883 NP_346370.1 CDS SP_1942 NC_003028.3 1845975 1846991 R transcriptional regulator complement(1845975..1846991) Streptococcus pneumoniae TIGR4 930155 NP_346371.1 CDS SP_1943 NC_003028.3 1846999 1847517 R acetyltransferase complement(1846999..1847517) Streptococcus pneumoniae TIGR4 931925 NP_346372.1 CDS SP_1944 NC_003028.3 1847507 1847950 R hypothetical protein complement(1847507..1847950) Streptococcus pneumoniae TIGR4 929943 NP_346373.1 CDS SP_1945 NC_003028.3 1848036 1848656 R hypothetical protein complement(1848036..1848656) Streptococcus pneumoniae TIGR4 931898 NP_346374.1 CDS SP_1946 NC_003028.3 1849039 1849902 R transcriptional regulator PlcR complement(1849039..1849902) Streptococcus pneumoniae TIGR4 930492 NP_346375.1 CDS SP_1947 NC_003028.3 1850094 1850264 D hypothetical protein 1850094..1850264 Streptococcus pneumoniae TIGR4 931992 NP_346376.1 CDS SP_1948 NC_003028.3 1850367 1850591 D similar to PID:559859; identified by sequence similarity; hypothetical protein 1850367..1850591 Streptococcus pneumoniae TIGR4 930068 NP_346377.1 CDS SP_1949 NC_003028.3 1850598 1850786 D hypothetical protein 1850598..1850786 Streptococcus pneumoniae TIGR4 929914 NP_346378.1 CDS SP_1950 NC_003028.3 1850902 1853892 D similar to SP:P37609 PID:433322; identified by sequence similarity; bacteriocin formation protein 1850902..1853892 Streptococcus pneumoniae TIGR4 930104 NP_346379.1 CDS SP_1951 NC_003028.3 1854242 1854946 D hypothetical protein 1854242..1854946 Streptococcus pneumoniae TIGR4 931919 NP_346380.1 CDS SP_1952 NC_003028.3 1854927 1855856 D hypothetical protein 1854927..1855856 Streptococcus pneumoniae TIGR4 930283 NP_346381.1 CDS SP_1953 NC_003028.3 1855865 1857961 D toxin secretion ABC transporter ATP-binding protein/permease 1855865..1857961 Streptococcus pneumoniae TIGR4 931975 YP_873937.1 CDS SP_1954 NC_003028.3 1857994 1859397 D serine protease subtilase 1857994..1859397 Streptococcus pneumoniae TIGR4 930312 NP_346382.1 CDS SP_1955 NC_003028.3 1859412 1859723 D hypothetical protein 1859412..1859723 Streptococcus pneumoniae TIGR4 930113 NP_346383.1 CDS SP_1956 NC_003028.3 1859774 1860541 D hypothetical protein 1859774..1860541 Streptococcus pneumoniae TIGR4 931916 NP_346384.1 CDS SP_1957 NC_003028.3 1860543 1861175 D ABC transporter ATP-binding protein 1860543..1861175 Streptococcus pneumoniae TIGR4 929998 NP_346385.1 CDS SP_1958 NC_003028.3 1861333 1861494 D hypothetical protein 1861333..1861494 Streptococcus pneumoniae TIGR4 931900 NP_346386.1 CDS ndk NC_003028.3 1862121 1862534 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(1862121..1862534) Streptococcus pneumoniae TIGR4 929787 NP_346387.1 CDS SP_1960 NC_003028.3 1862645 1866322 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(1862645..1866322) Streptococcus pneumoniae TIGR4 931871 NP_346388.1 CDS rpoB NC_003028.3 1866355 1869966 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(1866355..1869966) Streptococcus pneumoniae TIGR4 930094 NP_346389.1 CDS SP_1962 NC_003028.3 1870422 1870529 D hypothetical protein 1870422..1870529 Streptococcus pneumoniae TIGR4 929910 NP_346390.1 CDS SP_1963 NC_003028.3 1870650 1871981 R hypothetical protein complement(1870650..1871981) Streptococcus pneumoniae TIGR4 931894 NP_346391.1 CDS SP_1964 NC_003028.3 1872210 1873034 R DNA-entry nuclease complement(1872210..1873034) Streptococcus pneumoniae TIGR4 929957 NP_346392.1 CDS SP_1965 NC_003028.3 1873073 1873279 R hypothetical protein complement(1873073..1873279) Streptococcus pneumoniae TIGR4 929832 NP_346393.1 CDS SP_1966 NC_003028.3 1873254 1874537 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(1873254..1874537) Streptococcus pneumoniae TIGR4 931882 NP_346394.1 CDS SP_1967 NC_003028.3 1874849 1875886 R hypothetical protein complement(1874849..1875886) Streptococcus pneumoniae TIGR4 929799 NP_346395.1 CDS coaD NC_003028.3 1875870 1876358 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(1875870..1876358) Streptococcus pneumoniae TIGR4 931873 NP_346396.1 CDS SP_1969 NC_003028.3 1876348 1876887 R type II DNA modification methyltransferase complement(1876348..1876887) Streptococcus pneumoniae TIGR4 929836 NP_346397.1 CDS SP_1970 NC_003028.3 1876952 1877944 R catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA complement(1876952..1877944) Streptococcus pneumoniae TIGR4 931885 NP_346398.1 CDS SP_1971 NC_003028.3 1877918 1878082 D hypothetical protein 1877918..1878082 Streptococcus pneumoniae TIGR4 929783 NP_346399.1 CDS SP_1972 NC_003028.3 1878056 1878763 R identified by match to PFAM protein family HMM PF01027; hypothetical protein complement(1878056..1878763) Streptococcus pneumoniae TIGR4 930066 NP_346400.1 CDS SP_1973 NC_003028.3 1878795 1879535 R spoU rRNA methylase complement(1878795..1879535) Streptococcus pneumoniae TIGR4 931909 NP_346401.1 CDS SP_1974 NC_003028.3 1879569 1879847 D catalyzes the hydrolysis of acylphosphate; acylphosphatase 1879569..1879847 Streptococcus pneumoniae TIGR4 929925 NP_346402.1 CDS SP_1975 NC_003028.3 1879925 1880851 D involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor 1879925..1880851 Streptococcus pneumoniae TIGR4 929760 NP_346403.1 CDS SP_1976 NC_003028.3 1880926 1881720 R identified by match to PFAM protein family HMM PF02143; pyruvate formate-lyase-activating enzyme complement(1880926..1881720) Streptococcus pneumoniae TIGR4 929784 NP_346404.1 CDS SP_1977 NC_003028.3 1881768 1881872 D hypothetical protein 1881768..1881872 Streptococcus pneumoniae TIGR4 929803 NP_346405.1 CDS SP_1978 NC_003028.3 1881846 1883096 R diaminopimelate decarboxylase complement(1881846..1883096) Streptococcus pneumoniae TIGR4 931875 NP_346406.1 CDS SP_1979 NC_003028.3 1883163 1883990 R pur operon repressor complement(1883163..1883990) Streptococcus pneumoniae TIGR4 929904 NP_346407.1 CDS SP_1980 NC_003028.3 1884257 1885183 R cmp-binding-factor 1 complement(1884257..1885183) Streptococcus pneumoniae TIGR4 931892 NP_346408.1 CDS SP_1981 NC_003028.3 1885188 1886444 R hypothetical protein complement(1885188..1886444) Streptococcus pneumoniae TIGR4 929946 NP_346409.1 CDS SP_1982 NC_003028.3 1886446 1887129 R hypothetical protein complement(1886446..1887129) Streptococcus pneumoniae TIGR4 929862 NP_346410.1 CDS SP_1983 NC_003028.3 1887071 1887727 R identified by match to PFAM protein family HMM PF00834; ribulose-phosphate 3-epimerase complement(1887071..1887727) Streptococcus pneumoniae TIGR4 931887 NP_346411.1 CDS SP_1984 NC_003028.3 1887738 1888616 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(1887738..1888616) Streptococcus pneumoniae TIGR4 930526 NP_346412.1 CDS ksgA NC_003028.3 1888618 1889457 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(1888618..1889457) Streptococcus pneumoniae TIGR4 929819 NP_346413.1 CDS SP_1986 NC_003028.3 1889621 1889935 R hypothetical protein complement(1889621..1889935) Streptococcus pneumoniae TIGR4 931879 NP_346414.1 CDS SP_1987 NC_003028.3 1889922 1890563 R ABC transporter ATP-binding protein complement(1889922..1890563) Streptococcus pneumoniae TIGR4 929919 NP_346415.1 CDS SP_1988 NC_003028.3 1890565 1892598 R similar to GP:3355783; identified by sequence similarity; immunity protein complement(1890565..1892598) Streptococcus pneumoniae TIGR4 931896 NP_346416.1 CDS SP_1989 NC_003028.3 1892864 1893763 R transcriptional regulator PlcR complement(1892864..1893763) Streptococcus pneumoniae TIGR4 929751 NP_346417.1 CDS SP_1990 NC_003028.3 1893835 1894395 R primase-like protein complement(1893835..1894395) Streptococcus pneumoniae TIGR4 930004 NP_346418.1 CDS SP_1991 NC_003028.3 1894395 1895168 R identified by match to PFAM protein family HMM PF01026; hydrolase complement(1894395..1895168) Streptococcus pneumoniae TIGR4 931903 NP_346419.1 CDS SP_1992 NC_003028.3 1895473 1896138 R identified by match to PFAM protein family HMM PF00746; cell wall surface anchor family protein complement(1895473..1896138) Streptococcus pneumoniae TIGR4 930321 NP_346420.1 CDS rpmH NC_003028.3 1896650 1896784 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(1896650..1896784) Streptococcus pneumoniae TIGR4 930208 NP_346421.1 CDS SP_1994 NC_003028.3 1896929 1898143 R broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase complement(1896929..1898143) Streptococcus pneumoniae TIGR4 932041 NP_346422.1 CDS SP_1995 NC_003028.3 1898183 1898593 R hypothetical protein complement(1898183..1898593) Streptococcus pneumoniae TIGR4 930164 NP_346423.1 CDS SP_1996 NC_003028.3 1898755 1899207 D identified by match to PFAM protein family HMM PF00582; universal stress protein 1898755..1899207 Streptococcus pneumoniae TIGR4 931917 NP_346424.1 CDS SP_1997 NC_003028.3 1899242 1900630 R Cof family protein complement(1899242..1900630) Streptococcus pneumoniae TIGR4 929913 NP_346425.1 CDS SP_1998 NC_003028.3 1900696 1901658 D identified by match to PFAM protein family HMM PF00710; L-asparaginase 1900696..1901658 Streptococcus pneumoniae TIGR4 931895 NP_346426.1 CDS SP_1999 NC_003028.3 1902314 1903324 R catabolite control protein A complement(1902314..1903324) Streptococcus pneumoniae TIGR4 930480 NP_346427.1 CDS SP_2000 NC_003028.3 1903749 1904348 R DNA-binding response regulator complement(1903749..1904348) Streptococcus pneumoniae TIGR4 931991 NP_346428.1 CDS SP_2001 NC_003028.3 1904349 1905446 R sensor histidine kinase complement(1904349..1905446) Streptococcus pneumoniae TIGR4 930338 NP_346429.1 CDS SP_2002 NC_003028.3 1905446 1906183 R hypothetical protein complement(1905446..1906183) Streptococcus pneumoniae TIGR4 931986 NP_346430.1 CDS SP_2003 NC_003028.3 1906185 1907069 R ABC transporter ATP-binding protein complement(1906185..1907069) Streptococcus pneumoniae TIGR4 929970 NP_346431.1 CDS SP_2004 NC_003028.3 1907056 1907250 R hypothetical protein complement(1907056..1907250) Streptococcus pneumoniae TIGR4 931901 NP_346432.1 CDS SP_2005 NC_003028.3 1907247 1907378 R hypothetical protein complement(1907247..1907378) Streptococcus pneumoniae TIGR4 930381 NP_346433.1 CDS SP_2006 NC_003028.3 1914134 1914613 R similar to GP:5739312; identified by sequence similarity; transcriptional regulator ComX2 complement(1914134..1914613) Streptococcus pneumoniae TIGR4 932002 NP_346434.1 CDS nusG NC_003028.3 1914735 1915271 R Modulates Rho-dependent transcription termination; transcription antitermination protein NusG complement(1914735..1915271) Streptococcus pneumoniae TIGR4 932003 NP_346435.1 CDS secE NC_003028.3 1915326 1915502 R forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(1915326..1915502) Streptococcus pneumoniae TIGR4 932007 NP_346436.1 CDS rpmG NC_003028.3 1915512 1915664 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 complement(1915512..1915664) Streptococcus pneumoniae TIGR4 932006 NP_346437.1 CDS SP_2010 NC_003028.3 1915717 1917912 R penicillin-binding protein 2A complement(1915717..1917912) Streptococcus pneumoniae TIGR4 932011 NP_346438.1 CDS SP_2011 NC_003028.3 1917999 1918874 D ribosomal large subunit pseudouridine synthase D 1917999..1918874 Streptococcus pneumoniae TIGR4 932008 NP_346439.1 CDS SP_2012 NC_003028.3 1918942 1919949 R catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; glyceraldehyde-3-phosphate dehydrogenase complement(1918942..1919949) Streptococcus pneumoniae TIGR4 932009 NP_346440.1 CDS SP_2013 NC_003028.3 1920126 1921106 R hypothetical protein complement(1920126..1921106) Streptococcus pneumoniae TIGR4 932037 NP_346441.1 CDS SP_2014 NC_003028.3 1921149 1921487 R IS630-Spn1, transposase Orf2 complement(1921149..1921487) Streptococcus pneumoniae TIGR4 932039 NP_346442.1 CDS SP_2015 NC_003028.3 1921596 1922012 R IS630-Spn1, transposase Orf1 complement(1921596..1922012) Streptococcus pneumoniae TIGR4 931996 NP_346443.1 CDS SP_2016 NC_003028.3 1922125 1922997 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase complement(1922125..1922997) Streptococcus pneumoniae TIGR4 932040 NP_346444.1 CDS SP_2017 NC_003028.3 1923234 1924544 D hypothetical protein 1923234..1924544 Streptococcus pneumoniae TIGR4 932016 NP_346445.1 CDS SP_2020 NC_003028.3 1925563 1926291 R GntR family transcriptional regulator complement(1925563..1926291) Streptococcus pneumoniae TIGR4 932018 NP_346446.1 CDS SP_2021 NC_003028.3 1926449 1927858 D glycosyl hydrolase 1926449..1927858 Streptococcus pneumoniae TIGR4 932019 NP_346447.1 CDS SP_2022 NC_003028.3 1927876 1929171 D PTS system transporter subunit IIC 1927876..1929171 Streptococcus pneumoniae TIGR4 932024 NP_346448.1 CDS SP_2023 NC_003028.3 1929176 1929484 D PTS system transporter subunit IIB 1929176..1929484 Streptococcus pneumoniae TIGR4 932022 NP_346449.1 CDS SP_2024 NC_003028.3 1929463 1929789 D PTS system transporter subunit IIA 1929463..1929789 Streptococcus pneumoniae TIGR4 932023 NP_346450.1 CDS SP_2025 NC_003028.3 1930261 1930356 D hypothetical protein 1930261..1930356 Streptococcus pneumoniae TIGR4 932027 NP_346451.1 CDS SP_2026 NC_003028.3 1930775 1933426 R identified by match to PFAM protein family HMM PF00465; bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1930775..1933426) Streptococcus pneumoniae TIGR4 932025 NP_346452.1 CDS SP_2027 NC_003028.3 1933726 1934136 R hypothetical protein complement(1933726..1934136) Streptococcus pneumoniae TIGR4 932026 NP_346453.1 CDS SP_2028 NC_003028.3 1934138 1934566 R identified by match to PFAM protein family HMM PF01451; phosphotyrosine protein phosphatase complement(1934138..1934566) Streptococcus pneumoniae TIGR4 932030 NP_346454.1 CDS yajC NC_003028.3 1934612 1934911 R member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC complement(1934612..1934911) Streptococcus pneumoniae TIGR4 932028 NP_346455.1 CDS SP_2030 NC_003028.3 1935028 1937004 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(1935028..1937004) Streptococcus pneumoniae TIGR4 932029 NP_346456.1 CDS SP_2031 NC_003028.3 1937118 1938209 R L-ascorbate 6-phosphate lactonase complement(1937118..1938209) Streptococcus pneumoniae TIGR4 932033 NP_346457.1 CDS SP_2032 NC_003028.3 1938321 1939994 R identified by match to PFAM protein family HMM PF00874; BglG family transcriptional regulator complement(1938321..1939994) Streptococcus pneumoniae TIGR4 932031 NP_346458.1 CDS araD NC_003028.3 1940173 1940856 R catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase complement(1940173..1940856) Streptococcus pneumoniae TIGR4 932032 NP_346459.1 CDS SP_2034 NC_003028.3 1940879 1941742 R L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase complement(1940879..1941742) Streptococcus pneumoniae TIGR4 932036 NP_346460.1 CDS ulaD NC_003028.3 1941746 1942411 R catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase complement(1941746..1942411) Streptococcus pneumoniae TIGR4 932034 NP_346461.1 CDS SP_2036 NC_003028.3 1942428 1942913 R PTS system transporter subunit IIA complement(1942428..1942913) Streptococcus pneumoniae TIGR4 932035 NP_346462.1 CDS SP_2037 NC_003028.3 1942990 1943271 R similar to GB:U14003 SP:P39302 PID:537035 GB:U00096 PID:1790638; identified by sequence similarity; PTS system transporter subunit IIB complement(1942990..1943271) Streptococcus pneumoniae TIGR4 931995 NP_346463.1 CDS ulaA NC_003028.3 1943294 1944751 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(1943294..1944751) Streptococcus pneumoniae TIGR4 932038 NP_346464.1 CDS SP_2039 NC_003028.3 1944882 1945505 R hypothetical protein complement(1944882..1945505) Streptococcus pneumoniae TIGR4 932042 NP_346465.1 CDS SP_2040 NC_003028.3 1945556 1946542 R jag protein complement(1945556..1946542) Streptococcus pneumoniae TIGR4 932015 NP_346466.1 CDS SP_2041 NC_003028.3 1946561 1947385 R SpoIIIJ family protein complement(1946561..1947385) Streptococcus pneumoniae TIGR4 932020 NP_346467.1 CDS rnpA NC_003028.3 1947360 1947731 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(1947360..1947731) Streptococcus pneumoniae TIGR4 932005 NP_346468.1 CDS SP_2043 NC_003028.3 1947748 1947879 R hypothetical protein complement(1947748..1947879) Streptococcus pneumoniae TIGR4 932000 NP_346469.1 CDS SP_2044 NC_003028.3 1947880 1949070 R AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase complement(1947880..1949070) Streptococcus pneumoniae TIGR4 932010 NP_346470.1 CDS SP_2045 NC_003028.3 1949121 1950074 R hypothetical protein complement(1949121..1950074) Streptococcus pneumoniae TIGR4 930307 NP_346471.1 CDS SP_2047 NC_003028.3 1950866 1951279 R similar to GP:5103043; identified by sequence similarity; hypothetical protein complement(1950866..1951279) Streptococcus pneumoniae TIGR4 930318 NP_346472.1 CDS SP_2048 NC_003028.3 1951257 1951718 R hypothetical protein complement(1951257..1951718) Streptococcus pneumoniae TIGR4 930322 NP_346473.1 CDS SP_2049 NC_003028.3 1951681 1951941 R hypothetical protein complement(1951681..1951941) Streptococcus pneumoniae TIGR4 931980 NP_346474.1 CDS SP_2050 NC_003028.3 1951946 1952350 R similar to GP:3211751; identified by sequence similarity; competence protein CglD complement(1951946..1952350) Streptococcus pneumoniae TIGR4 930320 NP_346475.1 CDS SP_2051 NC_003028.3 1952343 1952669 R similar to GP:3211750; identified by sequence similarity; competence protein CglC complement(1952343..1952669) Streptococcus pneumoniae TIGR4 930319 NP_346476.1 CDS SP_2052 NC_003028.3 1952671 1953543 R competence protein CglB complement(1952671..1953543) Streptococcus pneumoniae TIGR4 931979 NP_346477.1 CDS SP_2053 NC_003028.3 1953635 1954576 R competence protein CglA complement(1953635..1954576) Streptococcus pneumoniae TIGR4 930328 NP_346478.1 CDS SP_2054 NC_003028.3 1954652 1955023 R hypothetical protein complement(1954652..1955023) Streptococcus pneumoniae TIGR4 930329 NP_346479.1 CDS SP_2055 NC_003028.3 1955168 1956226 R zinc-containing alcohol dehydrogenase complement(1955168..1956226) Streptococcus pneumoniae TIGR4 931982 NP_346480.1 CDS SP_2056 NC_003028.3 1956389 1957540 R identified by match to TIGR protein family HMM TIGR00221; N-acetylglucosamine-6-phosphate deacetylase complement(1956389..1957540) Streptococcus pneumoniae TIGR4 930327 NP_346481.1 CDS SP_2057 NC_003028.3 1957693 1959510 R hypothetical protein complement(1957693..1959510) Streptococcus pneumoniae TIGR4 930324 NP_346482.1 CDS tgt NC_003028.3 1959608 1960750 R Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase complement(1959608..1960750) Streptococcus pneumoniae TIGR4 931981 NP_346483.1 CDS SP_2059 NC_003028.3 1960880 1961737 D hypothetical protein 1960880..1961737 Streptococcus pneumoniae TIGR4 930317 NP_346484.1 CDS SP_2060 NC_003028.3 1961765 1962409 R catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase complement(1961765..1962409) Streptococcus pneumoniae TIGR4 931978 NP_346485.1 CDS SP_2061 NC_003028.3 1962516 1962875 R hypothetical protein complement(1962516..1962875) Streptococcus pneumoniae TIGR4 930314 NP_346486.1 CDS SP_2062 NC_003028.3 1962886 1963311 R MarR family transcriptional regulator complement(1962886..1963311) Streptococcus pneumoniae TIGR4 930311 YP_873938.1 CDS SP_2063 NC_003028.3 1963634 1964746 R LysM domain-containing protein complement(1963634..1964746) Streptococcus pneumoniae TIGR4 930310 NP_346487.1 CDS SP_2064 NC_003028.3 1964912 1965532 R identified by match to PFAM protein family HMM PF00702; HAD superfamily hydrolase complement(1964912..1965532) Streptococcus pneumoniae TIGR4 930304 NP_346488.1 CDS SP_2065 NC_003028.3 1965536 1966771 R identified by match to PFAM protein family HMM PF01554; MATE efflux family protein complement(1965536..1966771) Streptococcus pneumoniae TIGR4 931983 NP_346489.1 CDS SP_2066 NC_003028.3 1966877 1968361 R catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase complement(1966877..1968361) Streptococcus pneumoniae TIGR4 930302 NP_346490.1 CDS SP_2067 NC_003028.3 1968437 1969714 R hypothetical protein complement(1968437..1969714) Streptococcus pneumoniae TIGR4 931977 NP_346491.1 CDS SP_2068 NC_003028.3 1976179 1976613 R cytidine/deoxycytidylate deaminase complement(1976179..1976613) Streptococcus pneumoniae TIGR4 930267 NP_346492.1 CDS gltX NC_003028.3 1976627 1978087 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(1976627..1978087) Streptococcus pneumoniae TIGR4 931970 NP_346493.1 CDS pgi NC_003028.3 1978211 1979560 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(1978211..1979560) Streptococcus pneumoniae TIGR4 930266 NP_346494.1 CDS SP_2071 NC_003028.3 1979547 1979726 R hypothetical protein complement(1979547..1979726) Streptococcus pneumoniae TIGR4 931972 NP_346495.1 CDS SP_2072 NC_003028.3 1979730 1980458 R glutamine amidotransferase, class-I complement(1979730..1980458) Streptococcus pneumoniae TIGR4 930265 NP_346496.1 CDS SP_2073 NC_003028.3 1980558 1982324 R ABC transporter ATP-binding protein/permease complement(1980558..1982324) Streptococcus pneumoniae TIGR4 930264 NP_346497.1 CDS SP_2075 NC_003028.3 1983116 1984810 R ABC transporter ATP-binding protein/permease complement(1983116..1984810) Streptococcus pneumoniae TIGR4 931969 NP_346498.1 CDS SP_2077 NC_003028.3 1987541 1987987 R transcriptional repressor complement(1987541..1987987) Streptococcus pneumoniae TIGR4 930261 NP_346499.1 CDS argS NC_003028.3 1988123 1989814 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1988123..1989814 Streptococcus pneumoniae TIGR4 931968 NP_346500.1 CDS SP_2079 NC_003028.3 1990129 1990518 R similar to PID:763133; identified by sequence similarity; IS1381 transposase protein B complement(1990129..1990518) Streptococcus pneumoniae TIGR4 930259 NP_346501.1 CDS SP_2081 NC_003028.3 1990696 1991157 D hypothetical protein 1990696..1991157 Streptococcus pneumoniae TIGR4 930258 NP_346502.1 CDS SP_2082 NC_003028.3 1991241 1991948 D response regulator 1991241..1991948 Streptococcus pneumoniae TIGR4 931964 NP_346503.1 CDS SP_2083 NC_003028.3 1991949 1993280 D sensor histidine kinase PnpS 1991949..1993280 Streptococcus pneumoniae TIGR4 930257 NP_346504.1 CDS SP_2084 NC_003028.3 1993447 1994322 D phosphate ABC transporter substrate-binding protein 1993447..1994322 Streptococcus pneumoniae TIGR4 931962 NP_346505.1 CDS SP_2085 NC_003028.3 1994440 1995303 D phosphate ABC transporter permease 1994440..1995303 Streptococcus pneumoniae TIGR4 930255 NP_346506.1 CDS SP_2086 NC_003028.3 1995296 1996111 D phosphate ABC transporter permease 1995296..1996111 Streptococcus pneumoniae TIGR4 931966 NP_346507.1 CDS SP_2087 NC_003028.3 1996113 1996865 D ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1996113..1996865 Streptococcus pneumoniae TIGR4 930254 NP_346508.1 CDS SP_2088 NC_003028.3 1996880 1997530 D similar to OMNI:NT01EC4457; identified by sequence similarity; phosphate transport system regulatory protein PhoU 1996880..1997530 Streptococcus pneumoniae TIGR4 930253 NP_346509.1 CDS SP_2090 NC_003028.3 1998138 1998578 R transcriptional regulator complement(1998138..1998578) Streptococcus pneumoniae TIGR4 931961 NP_346510.1 CDS gpsA NC_003028.3 1998790 1999806 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1998790..1999806 Streptococcus pneumoniae TIGR4 930250 NP_346511.1 CDS SP_2092 NC_003028.3 1999828 2000727 D identified by match to TIGR protein family HMM TIGR01099; UTP-glucose-1-phosphate uridylyltransferase 1999828..2000727 Streptococcus pneumoniae TIGR4 931965 NP_346512.1 CDS SP_2093 NC_003028.3 2001118 2002086 D hypothetical protein 2001118..2002086 Streptococcus pneumoniae TIGR4 930249 NP_346513.1 CDS SP_2094 NC_003028.3 2002387 2003064 R hypothetical protein complement(2002387..2003064) Streptococcus pneumoniae TIGR4 931960 NP_346514.1 CDS SP_2095 NC_003028.3 2003048 2003587 R 5-formyltetrahydrofolate cyclo-ligase complement(2003048..2003587) Streptococcus pneumoniae TIGR4 930248 NP_346515.1 CDS SP_2096 NC_003028.3 2003599 2004729 R M20/M25/M40 family peptidase complement(2003599..2004729) Streptococcus pneumoniae TIGR4 930247 NP_346516.1 CDS SP_2097 NC_003028.3 2004797 2005495 R 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(2004797..2005495) Streptococcus pneumoniae TIGR4 930246 NP_346517.1 CDS SP_2098 NC_003028.3 2005725 2006636 R hypothetical protein complement(2005725..2006636) Streptococcus pneumoniae TIGR4 930245 NP_346518.1 CDS SP_2099 NC_003028.3 2006701 2009166 R penicillin-binding protein 1B complement(2006701..2009166) Streptococcus pneumoniae TIGR4 930244 NP_346519.1 CDS SP_2100 NC_003028.3 2009308 2010564 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 2009308..2010564 Streptococcus pneumoniae TIGR4 931959 NP_346520.1 CDS SP_2101 NC_003028.3 2010642 2012705 R cation transporter E1-E2 family ATPase complement(2010642..2012705) Streptococcus pneumoniae TIGR4 930243 NP_346521.1 CDS SP_2102 NC_003028.3 2012707 2013018 R hypothetical protein complement(2012707..2013018) Streptococcus pneumoniae TIGR4 931958 NP_346522.1 CDS SP_2103 NC_003028.3 2013137 2013985 D similar to GB:D28496 SP:P36999 PID:460699 GB:U00096 PID:1736466; identified by sequence similarity; rRNA (guanine-N1-)-methyltransferase 2013137..2013985 Streptococcus pneumoniae TIGR4 930241 NP_346523.1 CDS SP_2104 NC_003028.3 2014501 2014707 R hypothetical protein complement(2014501..2014707) Streptococcus pneumoniae TIGR4 930240 NP_346524.1 CDS SP_2105 NC_003028.3 2014784 2015356 D hypothetical protein 2014784..2015356 Streptococcus pneumoniae TIGR4 931957 NP_346525.1 CDS SP_2106 NC_003028.3 2016399 2018657 R glycogen phosphorylase complement(2016399..2018657) Streptococcus pneumoniae TIGR4 930239 NP_346526.1 CDS SP_2107 NC_003028.3 2018683 2020200 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(2018683..2020200) Streptococcus pneumoniae TIGR4 931963 NP_346527.1 CDS SP_2108 NC_003028.3 2020750 2022021 D maltose/maltodextrin ABC transporter maltose/maltodextrin-binding protein 2020750..2022021 Streptococcus pneumoniae TIGR4 930238 NP_346528.1 CDS SP_2109 NC_003028.3 2022117 2023424 D maltodextrin ABC transporter permease 2022117..2023424 Streptococcus pneumoniae TIGR4 930237 NP_346529.1 CDS SP_2110 NC_003028.3 2023426 2024268 D maltodextrin ABC transporter permease 2023426..2024268 Streptococcus pneumoniae TIGR4 930236 NP_346530.1 CDS SP_2111 NC_003028.3 2024521 2025321 D similar to GB:L21856 SP:Q08510 PID:347186; identified by sequence similarity; malA protein 2024521..2025321 Streptococcus pneumoniae TIGR4 931971 NP_346531.1 CDS SP_2112 NC_003028.3 2025331 2026317 D maltose operon transcriptional repressor 2025331..2026317 Streptococcus pneumoniae TIGR4 930235 NP_346532.1 CDS SP_2113 NC_003028.3 2026609 2027550 R hypothetical protein complement(2026609..2027550) Streptococcus pneumoniae TIGR4 930234 NP_346533.1 CDS aspS NC_003028.3 2027528 2029291 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(2027528..2029291) Streptococcus pneumoniae TIGR4 931956 NP_346534.1 CDS SP_2115 NC_003028.3 2029643 2029873 R hypothetical protein complement(2029643..2029873) Streptococcus pneumoniae TIGR4 930233 NP_346535.1 CDS SP_2116 NC_003028.3 2029891 2030532 R similar to PID:1402529; identified by sequence similarity; hypothetical protein complement(2029891..2030532) Streptococcus pneumoniae TIGR4 931952 NP_346536.1 CDS SP_2117 NC_003028.3 2030544 2031224 R hypothetical protein complement(2030544..2031224) Streptococcus pneumoniae TIGR4 930232 NP_346537.1 CDS SP_2118 NC_003028.3 2031280 2031480 R hypothetical protein complement(2031280..2031480) Streptococcus pneumoniae TIGR4 930231 NP_346538.1 CDS SP_2119 NC_003028.3 2031477 2031692 R transcriptional regulator complement(2031477..2031692) Streptococcus pneumoniae TIGR4 930229 NP_346539.1 CDS SP_2120 NC_003028.3 2031693 2032160 R hypothetical protein complement(2031693..2032160) Streptococcus pneumoniae TIGR4 930228 NP_346540.1 CDS hisS NC_003028.3 2032438 2033727 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(2032438..2033727) Streptococcus pneumoniae TIGR4 931955 NP_346541.1 CDS SP_2122 NC_003028.3 2033805 2035052 R hypothetical protein complement(2033805..2035052) Streptococcus pneumoniae TIGR4 930227 NP_346542.1 CDS SP_2124 NC_003028.3 2036068 2036202 R hypothetical protein complement(2036068..2036202) Streptococcus pneumoniae TIGR4 930225 NP_346543.1 CDS SP_2125 NC_003028.3 2036217 2036558 D hypothetical protein 2036217..2036558 Streptococcus pneumoniae TIGR4 931954 NP_346544.1 CDS SP_2126 NC_003028.3 2036860 2038563 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(2036860..2038563) Streptococcus pneumoniae TIGR4 930224 NP_346545.1 CDS SP_2127 NC_003028.3 2038796 2039728 R similar to GB:AE000512; identified by sequence similarity; transketolase, C-terminal subunit complement(2038796..2039728) Streptococcus pneumoniae TIGR4 931951 NP_346546.1 CDS SP_2128 NC_003028.3 2039725 2040582 R identified by match to PFAM protein family HMM PF00456; transketolase complement(2039725..2040582) Streptococcus pneumoniae TIGR4 930222 NP_346547.1 CDS ulaA NC_003028.3 2040586 2041932 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(2040586..2041932) Streptococcus pneumoniae TIGR4 931949 NP_346548.1 CDS SP_2130 NC_003028.3 2041945 2042229 R similar to GB:U14003 SP:P39302 PID:537035 GB:U00096 PID:1790638; identified by sequence similarity; PTS system transporter subunit IIB complement(2041945..2042229) Streptococcus pneumoniae TIGR4 930221 NP_346549.1 CDS SP_2131 NC_003028.3 2042233 2044263 R BglG family transcriptional regulator complement(2042233..2044263) Streptococcus pneumoniae TIGR4 931948 NP_346550.1 CDS SP_2132 NC_003028.3 2044455 2045462 D hypothetical protein 2044455..2045462 Streptococcus pneumoniae TIGR4 930220 NP_346551.1 CDS SP_2133 NC_003028.3 2045465 2045665 D similar to GP:9967664; identified by sequence similarity; hypothetical protein 2045465..2045665 Streptococcus pneumoniae TIGR4 931947 NP_346552.1 CDS rpmF NC_003028.3 2045817 2045999 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 2045817..2045999 Streptococcus pneumoniae TIGR4 930219 NP_346553.1 CDS rpmG NC_003028.3 2046015 2046164 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 2046015..2046164 Streptococcus pneumoniae TIGR4 930218 NP_346554.1 CDS SP_2136 NC_003028.3 2046656 2048521 R choline binding protein PcpA complement(2046656..2048521) Streptococcus pneumoniae TIGR4 931946 NP_346555.1 CDS SP_2138 NC_003028.3 2049407 2049796 D similar to PID:763133; identified by sequence similarity; IS1381 transposase protein B 2049407..2049796 Streptococcus pneumoniae TIGR4 931945 NP_346556.1 CDS SP_2139 NC_003028.3 2049848 2050174 R hypothetical protein complement(2049848..2050174) Streptococcus pneumoniae TIGR4 930216 NP_346557.1 CDS SP_2140 NC_003028.3 2050211 2050420 R hypothetical protein complement(2050211..2050420) Streptococcus pneumoniae TIGR4 931943 NP_346558.1 CDS SP_2141 NC_003028.3 2050572 2052452 R similar to SP:P43077 PID:432354; identified by sequence similarity; glycosyl hydrolase-like protein complement(2050572..2052452) Streptococcus pneumoniae TIGR4 930215 NP_346559.1 CDS SP_2142 NC_003028.3 2052446 2053315 R ROK family protein complement(2052446..2053315) Streptococcus pneumoniae TIGR4 931944 NP_346560.1 CDS SP_2143 NC_003028.3 2053398 2056058 R hypothetical protein complement(2053398..2056058) Streptococcus pneumoniae TIGR4 930214 NP_346561.1 CDS SP_2144 NC_003028.3 2056134 2057414 R hypothetical protein complement(2056134..2057414) Streptococcus pneumoniae TIGR4 931941 NP_346562.1 CDS SP_2145 NC_003028.3 2057586 2059670 D cell wall antigen 2057586..2059670 Streptococcus pneumoniae TIGR4 930213 NP_346563.1 CDS SP_2146 NC_003028.3 2059710 2061389 R hypothetical protein complement(2059710..2061389) Streptococcus pneumoniae TIGR4 931940 NP_346564.1 CDS SP_2147 NC_003028.3 2061782 2062006 D hypothetical protein 2061782..2062006 Streptococcus pneumoniae TIGR4 930212 NP_346565.1 CDS SP_2148 NC_003028.3 2062144 2063373 D catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 2062144..2063373 Streptococcus pneumoniae TIGR4 931942 NP_346566.1 CDS SP_2150 NC_003028.3 2063431 2064447 D catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 2063431..2064447 Streptococcus pneumoniae TIGR4 930211 NP_346567.1 CDS SP_2151 NC_003028.3 2064612 2065559 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 2064612..2065559 Streptococcus pneumoniae TIGR4 930210 NP_346568.1 CDS SP_2152 NC_003028.3 2065768 2067279 D hypothetical protein 2065768..2067279 Streptococcus pneumoniae TIGR4 930207 NP_346569.1 CDS SP_2153 NC_003028.3 2067301 2068632 D hypothetical protein 2067301..2068632 Streptococcus pneumoniae TIGR4 931937 NP_346570.1 CDS SP_2156 NC_003028.3 2069966 2070790 R hypothetical protein complement(2069966..2070790) Streptococcus pneumoniae TIGR4 930205 NP_346571.1 CDS SP_2157 NC_003028.3 2070995 2072146 R identified by match to PFAM protein family HMM PF00465; iron-containing alcohol dehydrogenase complement(2070995..2072146) Streptococcus pneumoniae TIGR4 931936 NP_346572.1 CDS fucI NC_003028.3 2072292 2074058 R catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase complement(2072292..2074058) Streptococcus pneumoniae TIGR4 930204 NP_346573.1 CDS SP_2159 NC_003028.3 2074141 2077257 R similar to GP:9651025; identified by sequence similarity; fucolectin-like protein complement(2074141..2077257) Streptococcus pneumoniae TIGR4 931935 NP_346574.1 CDS SP_2160 NC_003028.3 2077267 2079561 R hypothetical protein complement(2077267..2079561) Streptococcus pneumoniae TIGR4 930203 NP_346575.1 CDS SP_2161 NC_003028.3 2079620 2080420 R PTS system transporter subunit IID complement(2079620..2080420) Streptococcus pneumoniae TIGR4 931934 NP_346576.1 CDS SP_2162 NC_003028.3 2080417 2081190 R PTS system transporter subunit IIC complement(2080417..2081190) Streptococcus pneumoniae TIGR4 930202 NP_346577.1 CDS SP_2163 NC_003028.3 2081215 2081685 R PTS system transporter subunit IIB complement(2081215..2081685) Streptococcus pneumoniae TIGR4 931933 NP_346578.1 CDS SP_2164 NC_003028.3 2081676 2082107 R PTS system transporter subunit IIA complement(2081676..2082107) Streptococcus pneumoniae TIGR4 930201 NP_346579.1 CDS SP_2165 NC_003028.3 2082097 2082540 R similar to GB:L42023 SP:P44778 PID:1005441 PID:1220689 PID:1204863; identified by sequence similarity; fucose operon FucU protein complement(2082097..2082540) Streptococcus pneumoniae TIGR4 931939 NP_346580.1 CDS SP_2166 NC_003028.3 2082552 2083190 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(2082552..2083190) Streptococcus pneumoniae TIGR4 930200 NP_346581.1 CDS SP_2167 NC_003028.3 2083305 2084708 R L-fuculose kinase fucK complement(2083305..2084708) Streptococcus pneumoniae TIGR4 931931 NP_346582.1 CDS SP_2168 NC_003028.3 2084884 2085657 D fucose operon repressor 2084884..2085657 Streptococcus pneumoniae TIGR4 930197 NP_346583.1 CDS SP_2169 NC_003028.3 2086817 2088322 R identified by match to PFAM protein family HMM PF01297; zinc ABC transporter zinc-binding lipoprotein complement(2086817..2088322) Streptococcus pneumoniae TIGR4 931930 NP_346584.1 CDS SP_2170 NC_003028.3 2088332 2089138 R identified by match to PFAM protein family HMM PF00950; zinc ABC transporter permease complement(2088332..2089138) Streptococcus pneumoniae TIGR4 930196 NP_346585.1 CDS SP_2171 NC_003028.3 2089131 2089835 R zinc ABC transporter ATP-binding protein complement(2089131..2089835) Streptococcus pneumoniae TIGR4 930195 NP_346586.1 CDS SP_2172 NC_003028.3 2089835 2090275 R adc operon repressor AdcR complement(2089835..2090275) Streptococcus pneumoniae TIGR4 931929 NP_346587.1 CDS SP_2173 NC_003028.3 2090430 2091680 R similar to GP:6456613; identified by sequence similarity; dltD protein complement(2090430..2091680) Streptococcus pneumoniae TIGR4 930194 NP_346588.1 CDS SP_2174 NC_003028.3 2091691 2091930 R D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 complement(2091691..2091930) Streptococcus pneumoniae TIGR4 930193 NP_346589.1 CDS SP_2175 NC_003028.3 2091944 2093185 R similar to GP:2952530; identified by sequence similarity; dltB protein complement(2091944..2093185) Streptococcus pneumoniae TIGR4 930192 NP_346590.1 CDS SP_2176 NC_003028.3 2093185 2094735 R transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 complement(2093185..2094735) Streptococcus pneumoniae TIGR4 931927 NP_346591.1 CDS SP_2177 NC_003028.3 2094756 2094890 R hypothetical protein complement(2094756..2094890) Streptococcus pneumoniae TIGR4 930191 NP_346592.1 CDS SP_2179 NC_003028.3 2095739 2097085 R similar to GP:8163721; identified by sequence similarity; IS1380-Spn1 transposase complement(2095739..2097085) Streptococcus pneumoniae TIGR4 930190 NP_346593.1 CDS SP_2182 NC_003028.3 2100871 2101458 D hypothetical protein 2100871..2101458 Streptococcus pneumoniae TIGR4 931928 NP_346594.1 CDS SP_2183 NC_003028.3 2101545 2101748 R hypothetical protein complement(2101545..2101748) Streptococcus pneumoniae TIGR4 930188 NP_346595.1 CDS SP_2184 NC_003028.3 2102045 2102749 R identified by match to PFAM protein family HMM PF00230; glycerol uptake facilitator protein complement(2102045..2102749) Streptococcus pneumoniae TIGR4 931924 NP_346596.1 CDS SP_2185 NC_003028.3 2102819 2104645 R hypothetical protein complement(2102819..2104645) Streptococcus pneumoniae TIGR4 930187 NP_346597.1 CDS glpK NC_003028.3 2104687 2106195 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(2104687..2106195) Streptococcus pneumoniae TIGR4 931923 NP_346598.1 CDS SP_2187 NC_003028.3 2106354 2107781 R similar to GP:409925; identified by sequence similarity; hypothetical protein complement(2106354..2107781) Streptococcus pneumoniae TIGR4 930185 NP_346599.1 CDS hslO NC_003028.3 2107946 2108818 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; heat shock protein 33 2107946..2108818 Streptococcus pneumoniae TIGR4 931922 NP_346600.1 CDS SP_2189 NC_003028.3 2108829 2109785 D identified by match to PFAM protein family HMM PF01207; NifR3 family TIM-barrel protein 2108829..2109785 Streptococcus pneumoniae TIGR4 930184 NP_346601.1 CDS SP_2190 NC_003028.3 2110015 2112096 R choline binding protein A complement(2110015..2112096) Streptococcus pneumoniae TIGR4 931921 NP_346602.1 CDS SP_2191 NC_003028.3 2112175 2112702 R hypothetical protein complement(2112175..2112702) Streptococcus pneumoniae TIGR4 930183 NP_346603.1 CDS SP_2192 NC_003028.3 2112785 2114116 R sensor histidine kinase complement(2112785..2114116) Streptococcus pneumoniae TIGR4 931920 NP_346604.1 CDS SP_2193 NC_003028.3 2114113 2114766 R DNA-binding response regulator complement(2114113..2114766) Streptococcus pneumoniae TIGR4 930182 NP_346605.1 CDS SP_2194 NC_003028.3 2115408 2117840 R ATP-dependent Clp protease ATP-binding subunit complement(2115408..2117840) Streptococcus pneumoniae TIGR4 931938 NP_346606.1 CDS SP_2195 NC_003028.3 2117842 2118300 R similar to GB:D26185 SP:P37568 PID:467471 GB:AL009126; identified by sequence similarity; CtsR family transcriptional regulator complement(2117842..2118300) Streptococcus pneumoniae TIGR4 930181 NP_346607.1 CDS SP_2196 NC_003028.3 2118419 2119147 R ABC transporter ATP-binding protein complement(2118419..2119147) Streptococcus pneumoniae TIGR4 930180 NP_346608.1 CDS SP_2197 NC_003028.3 2119147 2120154 R similar to GB:AE001363; identified by sequence similarity; ABC transporter substrate-binding protein complement(2119147..2120154) Streptococcus pneumoniae TIGR4 930179 NP_346609.1 CDS SP_2198 NC_003028.3 2120193 2120942 R ABC transporter permease complement(2120193..2120942) Streptococcus pneumoniae TIGR4 931918 NP_346610.1 CDS SP_2199 NC_003028.3 2120914 2121204 R hypothetical protein complement(2120914..2121204) Streptococcus pneumoniae TIGR4 930493 NP_346611.1 CDS SP_2200 NC_003028.3 2121383 2121493 D hypothetical protein 2121383..2121493 Streptococcus pneumoniae TIGR4 930058 NP_346612.1 CDS SP_2201 NC_003028.3 2121460 2122806 R choline binding protein D complement(2121460..2122806) Streptococcus pneumoniae TIGR4 931907 NP_346613.1 CDS SP_2202 NC_003028.3 2122895 2123161 R hypothetical protein complement(2122895..2123161) Streptococcus pneumoniae TIGR4 930008 NP_346614.1 CDS SP_2203 NC_003028.3 2123163 2124515 R unwinds double stranded DNA; replicative DNA helicase complement(2123163..2124515) Streptococcus pneumoniae TIGR4 931904 NP_346615.1 CDS rplI NC_003028.3 2124559 2125011 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(2124559..2125011) Streptococcus pneumoniae TIGR4 929818 NP_346616.1 CDS SP_2205 NC_003028.3 2125008 2126981 R identified by match to PFAM protein family HMM PF02272; DHH subfamily 1 protein complement(2125008..2126981) Streptococcus pneumoniae TIGR4 929903 NP_346617.1 CDS SP_2206 NC_003028.3 2127117 2127665 R ribosomal subunit interface protein complement(2127117..2127665) Streptococcus pneumoniae TIGR4 931897 NP_346618.1 CDS SP_2207 NC_003028.3 2127745 2128407 R identified by match to TIGR protein family HMM TIGR00201; competence protein ComF complement(2127745..2128407) Streptococcus pneumoniae TIGR4 929909 NP_346619.1 CDS SP_2208 NC_003028.3 2128404 2129702 R helicase complement(2128404..2129702) Streptococcus pneumoniae TIGR4 931893 NP_346620.1 CDS SP_2209 NC_003028.3 2129758 2130393 D hypothetical protein 2129758..2130393 Streptococcus pneumoniae TIGR4 929929 NP_346621.1 CDS SP_2210 NC_003028.3 2130642 2131562 D identified by match to TIGR protein family HMM TIGR01139; cysteine synthase 2130642..2131562 Streptococcus pneumoniae TIGR4 929865 NP_346622.1 CDS tsf NC_003028.3 2133145 2134185 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(2133145..2134185) Streptococcus pneumoniae TIGR4 931906 NP_346623.1 CDS rpsB NC_003028.3 2134264 2135043 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(2134264..2135043) Streptococcus pneumoniae TIGR4 929982 NP_346624.1 CDS SP_2216 NC_003028.3 2135267 2136445 R similar to GB:M60178 SP:P22865 PID:149525 PID:512521; identified by sequence similarity; hypothetical protein complement(2135267..2136445) Streptococcus pneumoniae TIGR4 929879 NP_346625.1 CDS SP_2217 NC_003028.3 2136539 2137033 R similar to GP:9246949; identified by sequence similarity; rod shpae-determining protein MreD complement(2136539..2137033) Streptococcus pneumoniae TIGR4 929895 NP_346626.1 CDS SP_2218 NC_003028.3 2137033 2137851 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(2137033..2137851) Streptococcus pneumoniae TIGR4 929881 NP_346627.1 CDS SP_2219 NC_003028.3 2137910 2138704 R hypothetical protein complement(2137910..2138704) Streptococcus pneumoniae TIGR4 931890 NP_346628.1 CDS cbiO NC_003028.3 2138697 2139536 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2138697..2139536) Streptococcus pneumoniae TIGR4 929887 NP_346629.1 CDS cbiO NC_003028.3 2139521 2140348 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2139521..2140348) Streptococcus pneumoniae TIGR4 931891 NP_346630.1 CDS SP_2222 NC_003028.3 2140345 2140890 R identified by match to PFAM protein family HMM PF01066; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase complement(2140345..2140890) Streptococcus pneumoniae TIGR4 929871 NP_346631.1 CDS SP_2223 NC_003028.3 2140901 2141731 R hypothetical protein complement(2140901..2141731) Streptococcus pneumoniae TIGR4 931889 NP_346632.1 CDS SP_2224 NC_003028.3 2141764 2143047 R identified by match to PFAM protein family HMM PF00675; M16 family peptidase complement(2141764..2143047) Streptococcus pneumoniae TIGR4 929843 NP_346633.1 CDS SP_2225 NC_003028.3 2143044 2144294 R hypothetical protein complement(2143044..2144294) Streptococcus pneumoniae TIGR4 929864 NP_346634.1 CDS SP_2226 NC_003028.3 2144453 2144821 D hypothetical protein 2144453..2144821 Streptococcus pneumoniae TIGR4 931888 NP_346635.1 CDS recF NC_003028.3 2144824 2145921 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2144824..2145921 Streptococcus pneumoniae TIGR4 929856 NP_346636.1 CDS SP_2228 NC_003028.3 2145972 2147450 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2145972..2147450) Streptococcus pneumoniae TIGR4 931886 NP_346637.1 CDS SP_2229 NC_003028.3 2147602 2148627 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(2147602..2148627) Streptococcus pneumoniae TIGR4 930554 NP_346638.1 CDS SP_2230 NC_003028.3 2148833 2150455 D ABC transporter ATP-binding protein 2148833..2150455 Streptococcus pneumoniae TIGR4 929840 NP_346639.1 CDS SP_2231 NC_003028.3 2150517 2153069 D ABC transporter permease 2150517..2153069 Streptococcus pneumoniae TIGR4 929826 NP_346640.1 CDS SP_2233 NC_003028.3 2153934 2154701 R hypothetical protein complement(2153934..2154701) Streptococcus pneumoniae TIGR4 929837 NP_346641.1 CDS SP_2234 NC_003028.3 2154880 2155422 D TetR family transcriptional regulator 2154880..2155422 Streptococcus pneumoniae TIGR4 931884 NP_346642.1 CDS SP_2235 NC_003028.3 2155665 2156417 R response regulator ComE complement(2155665..2156417) Streptococcus pneumoniae TIGR4 930062 NP_346643.1 CDS SP_2236 NC_003028.3 2156414 2157739 R sensor histidine kinase ComD complement(2156414..2157739) Streptococcus pneumoniae TIGR4 931908 NP_346644.1 CDS SP_2237 NC_003028.3 2157760 2157885 R similar to SP:P72507; identified by sequence similarity; competence stimulating peptide 2 complement(2157760..2157885) Streptococcus pneumoniae TIGR4 929807 NP_346645.1 CDS SP_2238 NC_003028.3 2158167 2158646 R SPOUT methyltransferase; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(2158167..2158646) Streptococcus pneumoniae TIGR4 931872 NP_346646.1 CDS SP_2239 NC_003028.3 2158829 2160010 D serine protease 2158829..2160010 Streptococcus pneumoniae TIGR4 929800 NP_346647.1 CDS SP_2240 NC_003028.3 2160068 2160826 D identified by match to PFAM protein family HMM PF02195; spspoJ protein 2160068..2160826 Streptococcus pneumoniae TIGR4 931874 SP_2242 tRNA tRNA-Glu-5 NC_003028.3 15023 15094 D tRNA-Glu 15023..15094 Streptococcus pneumoniae TIGR4 929753 SP_2243 tRNA tRNA-Ala-4 NC_003028.3 16945 17017 D tRNA-Ala 16945..17017 Streptococcus pneumoniae TIGR4 929757 SP_2244 tRNA tRNA-Asn-2 NC_003028.3 20241 20314 D tRNA-Asn 20241..20314 Streptococcus pneumoniae TIGR4 929761 SP_2245 tRNA tRNA-Tyr-2 NC_003028.3 807866 807946 D tRNA-Tyr 807866..807946 Streptococcus pneumoniae TIGR4 930812 SP_2246 tRNA tRNA-Gln-2 NC_003028.3 807956 808027 D tRNA-Gln 807956..808027 Streptococcus pneumoniae TIGR4 930813 SP_2247 tRNA tRNA-Ser-4 NC_003028.3 822458 822545 R tRNA-Ser complement(822458..822545) Streptococcus pneumoniae TIGR4 930827 SP_2248 tRNA tRNA-Thr-3 NC_003028.3 956607 956679 D tRNA-Thr 956607..956679 Streptococcus pneumoniae TIGR4 931526 SP_2249 tRNA tRNA-Arg-1 NC_003028.3 1183401 1183472 R tRNA-Arg complement(1183401..1183472) Streptococcus pneumoniae TIGR4 931762 SP_2250 tRNA tRNA-Arg-2 NC_003028.3 1227766 1227837 R tRNA-Arg complement(1227766..1227837) Streptococcus pneumoniae TIGR4 931807 SP_2251 tRNA tRNA-Leu-1 NC_003028.3 1487972 1488057 R tRNA-Leu complement(1487972..1488057) Streptococcus pneumoniae TIGR4 931249 SP_2252 tRNA tRNA-Lys-1 NC_003028.3 1706881 1706953 D tRNA-Lys 1706881..1706953 Streptococcus pneumoniae TIGR4 931044 SP_2253 tRNA tRNA-Ser-1 NC_003028.3 1808663 1808750 R tRNA-Ser complement(1808663..1808750) Streptococcus pneumoniae TIGR4 930931 SP_2254 tRNA tRNA-Ile-1 NC_003028.3 1808757 1808830 R tRNA-Ile complement(1808757..1808830) Streptococcus pneumoniae TIGR4 930923 SP_2255 tRNA tRNA-Gly-1 NC_003028.3 1808866 1808936 R tRNA-Gly complement(1808866..1808936) Streptococcus pneumoniae TIGR4 930928 SP_2256 tRNA tRNA-Phe-1 NC_003028.3 1808956 1809028 R tRNA-Phe complement(1808956..1809028) Streptococcus pneumoniae TIGR4 930930 SP_2257 tRNA tRNA-Met-1 NC_003028.3 1809032 1809105 R tRNA-Met complement(1809032..1809105) Streptococcus pneumoniae TIGR4 930929 SP_2258 tRNA tRNA-Ser-2 NC_003028.3 1809119 1809208 R tRNA-Ser complement(1809119..1809208) Streptococcus pneumoniae TIGR4 930927 SP_2259 tRNA tRNA-Met-2 NC_003028.3 1809219 1809292 R tRNA-Met complement(1809219..1809292) Streptococcus pneumoniae TIGR4 930926 SP_2260 tRNA tRNA-Met-3 NC_003028.3 1809306 1809379 R tRNA-Met complement(1809306..1809379) Streptococcus pneumoniae TIGR4 930925 SP_2261 tRNA tRNA-Pro-1 NC_003028.3 1809385 1809458 R tRNA-Pro complement(1809385..1809458) Streptococcus pneumoniae TIGR4 930924 SP_2262 tRNA tRNA-Arg-3 NC_003028.3 1809474 1809547 R tRNA-Arg complement(1809474..1809547) Streptococcus pneumoniae TIGR4 930922 SP_2263 tRNA tRNA-Leu-2 NC_003028.3 1809557 1809642 R tRNA-Leu complement(1809557..1809642) Streptococcus pneumoniae TIGR4 930921 SP_2264 tRNA tRNA-Gly-2 NC_003028.3 1809650 1809721 R tRNA-Gly complement(1809650..1809721) Streptococcus pneumoniae TIGR4 930920 SP_2265 tRNA tRNA-Thr-1 NC_003028.3 1809744 1809816 R tRNA-Thr complement(1809744..1809816) Streptococcus pneumoniae TIGR4 930919 SP_2266 tRNA tRNA-Leu-3 NC_003028.3 1809835 1809916 R tRNA-Leu complement(1809835..1809916) Streptococcus pneumoniae TIGR4 930909 SP_2267 tRNA tRNA-Lys-2 NC_003028.3 1809922 1809994 R tRNA-Lys complement(1809922..1809994) Streptococcus pneumoniae TIGR4 930917 SP_2268 tRNA tRNA-Asp-1 NC_003028.3 1810019 1810091 R tRNA-Asp complement(1810019..1810091) Streptococcus pneumoniae TIGR4 930918 SP_2269 tRNA tRNA-Val-1 NC_003028.3 1810094 1810166 R tRNA-Val complement(1810094..1810166) Streptococcus pneumoniae TIGR4 930916 SP_2270 tRNA tRNA-Ala-1 NC_003028.3 1813389 1813461 R tRNA-Ala complement(1813389..1813461) Streptococcus pneumoniae TIGR4 931997 SP_2271 tRNA tRNA-Glu-1 NC_003028.3 1815312 1815383 R tRNA-Glu complement(1815312..1815383) Streptococcus pneumoniae TIGR4 930288 SP_2272 tRNA tRNA-Cys-1 NC_003028.3 1870382 1870452 D tRNA-Cys 1870382..1870452 Streptococcus pneumoniae TIGR4 931913 SP_2273 tRNA tRNA-Pro-2 NC_003028.3 1908042 1908115 R tRNA-Pro complement(1908042..1908115) Streptococcus pneumoniae TIGR4 931988 SP_2274 tRNA tRNA-Arg-4 NC_003028.3 1908131 1908204 R tRNA-Arg complement(1908131..1908204) Streptococcus pneumoniae TIGR4 931985 SP_2275 tRNA tRNA-Leu-4 NC_003028.3 1908214 1908299 R tRNA-Leu complement(1908214..1908299) Streptococcus pneumoniae TIGR4 930047 SP_2276 tRNA tRNA-Gly-3 NC_003028.3 1908307 1908378 R tRNA-Gly complement(1908307..1908378) Streptococcus pneumoniae TIGR4 931911 SP_2277 tRNA tRNA-Thr-2 NC_003028.3 1908401 1908473 R tRNA-Thr complement(1908401..1908473) Streptococcus pneumoniae TIGR4 931914 SP_2278 tRNA tRNA-Leu-5 NC_003028.3 1908492 1908573 R tRNA-Leu complement(1908492..1908573) Streptococcus pneumoniae TIGR4 930548 SP_2279 tRNA tRNA-Lys-3 NC_003028.3 1908579 1908651 R tRNA-Lys complement(1908579..1908651) Streptococcus pneumoniae TIGR4 931993 SP_2280 tRNA tRNA-Asp-2 NC_003028.3 1908676 1908748 R tRNA-Asp complement(1908676..1908748) Streptococcus pneumoniae TIGR4 931905 SP_2281 tRNA tRNA-Val-2 NC_003028.3 1908751 1908823 R tRNA-Val complement(1908751..1908823) Streptococcus pneumoniae TIGR4 930430 SP_2282 tRNA tRNA-Ala-2 NC_003028.3 1912046 1912118 R tRNA-Ala complement(1912046..1912118) Streptococcus pneumoniae TIGR4 931998 SP_2283 tRNA tRNA-Glu-2 NC_003028.3 1913969 1914040 R tRNA-Glu complement(1913969..1914040) Streptococcus pneumoniae TIGR4 932004 SP_2284 tRNA tRNA-Leu-6 NC_003028.3 1969821 1969904 R tRNA-Leu complement(1969821..1969904) Streptococcus pneumoniae TIGR4 930297 SP_2285 tRNA tRNA-Gln-1 NC_003028.3 1969914 1969985 R tRNA-Gln complement(1969914..1969985) Streptococcus pneumoniae TIGR4 930293 SP_2286 tRNA tRNA-His-1 NC_003028.3 1969996 1970068 R tRNA-His complement(1969996..1970068) Streptococcus pneumoniae TIGR4 930290 SP_2287 tRNA tRNA-Trp-1 NC_003028.3 1970083 1970153 R tRNA-Trp complement(1970083..1970153) Streptococcus pneumoniae TIGR4 931974 SP_2288 tRNA tRNA-Tyr-1 NC_003028.3 1970158 1970238 R tRNA-Tyr complement(1970158..1970238) Streptococcus pneumoniae TIGR4 930287 SP_2289 tRNA tRNA-Phe-2 NC_003028.3 1970251 1970323 R tRNA-Phe complement(1970251..1970323) Streptococcus pneumoniae TIGR4 931973 SP_2290 tRNA tRNA-Met-4 NC_003028.3 1970327 1970400 R tRNA-Met complement(1970327..1970400) Streptococcus pneumoniae TIGR4 930281 SP_2291 tRNA tRNA-Ser-3 NC_003028.3 1970411 1970500 R tRNA-Ser complement(1970411..1970500) Streptococcus pneumoniae TIGR4 930280 SP_2292 tRNA tRNA-Ile-2 NC_003028.3 1970583 1970656 R tRNA-Ile complement(1970583..1970656) Streptococcus pneumoniae TIGR4 930278 SP_2293 tRNA tRNA-Gly-4 NC_003028.3 1970691 1970761 R tRNA-Gly complement(1970691..1970761) Streptococcus pneumoniae TIGR4 930276 SP_2294 tRNA tRNA-Val-3 NC_003028.3 1970767 1970839 R tRNA-Val complement(1970767..1970839) Streptococcus pneumoniae TIGR4 930275 SP_2295 tRNA tRNA-Ala-3 NC_003028.3 1974062 1974134 R tRNA-Ala complement(1974062..1974134) Streptococcus pneumoniae TIGR4 930272 SP_2296 tRNA tRNA-Glu-3 NC_003028.3 1975986 1976057 R tRNA-Glu complement(1975986..1976057) Streptococcus pneumoniae TIGR4 930270 SP_2297 tRNA tRNA-Asn-1 NC_003028.3 2155463 2155536 R tRNA-Asn complement(2155463..2155536) Streptococcus pneumoniae TIGR4 929831 SP_2298 tRNA tRNA-Glu-4 NC_003028.3 2155542 2155613 R tRNA-Glu complement(2155542..2155613) Streptococcus pneumoniae TIGR4 929824 SP_2299 tRNA tRNA-Arg-5 NC_003028.3 2158050 2158123 R tRNA-Arg complement(2158050..2158123) Streptococcus pneumoniae TIGR4 931876 SP_rrnaA16S rRNA SP_rrnaA16S NC_003028.3 15344 16903 D 16S ribosomal RNA 15344..16903 Streptococcus pneumoniae TIGR4 929754 SP_rrnaA23S rRNA SP_rrnaA23S NC_003028.3 17142 20043 D 23S ribosomal RNA 17142..20043 Streptococcus pneumoniae TIGR4 929758 SP_rrnaA5S rRNA SP_rrnaA5S NC_003028.3 20121 20236 D 5S ribosomal RNA 20121..20236 Streptococcus pneumoniae TIGR4 929759 SP_rrnaD5S rRNA SP_rrnaD5S NC_003028.3 1810171 1810293 R 5S ribosomal RNA complement(1810171..1810293) Streptococcus pneumoniae TIGR4 930915 SP_rrnaD23S rRNA SP_rrnaD23S NC_003028.3 1810363 1813264 R 23S ribosomal RNA complement(1810363..1813264) Streptococcus pneumoniae TIGR4 930914 SP_rrnaD16S rRNA SP_rrnaD16S NC_003028.3 1813505 1815064 R 16S ribosomal RNA complement(1813505..1815064) Streptococcus pneumoniae TIGR4 931976 SP_rrnaC5S rRNA SP_rrnaC5S NC_003028.3 1908828 1908950 R 5S ribosomal RNA complement(1908828..1908950) Streptococcus pneumoniae TIGR4 930491 SP_rrnaC23S rRNA SP_rrnaC23S NC_003028.3 1909020 1911921 R 23S ribosomal RNA complement(1909020..1911921) Streptococcus pneumoniae TIGR4 931999 SP_rrnaC16S rRNA SP_rrnaC16S NC_003028.3 1912162 1913721 R 16S ribosomal RNA complement(1912162..1913721) Streptococcus pneumoniae TIGR4 932001 SP_rrnaB5S rRNA SP_rrnaB5S NC_003028.3 1970844 1970966 R 5S ribosomal RNA complement(1970844..1970966) Streptococcus pneumoniae TIGR4 930274 SP_rrnaB23S rRNA SP_rrnaB23S NC_003028.3 1971036 1973937 R 23S ribosomal RNA complement(1971036..1973937) Streptococcus pneumoniae TIGR4 930273 SP_rrnaB16S rRNA SP_rrnaB16S NC_003028.3 1974178 1975734 R 16S ribosomal RNA complement(1974178..1975734) Streptococcus pneumoniae TIGR4 930271